tbuckley/cabot-search huggingface dataset:
Child Guidance.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgical teaching in the development of clinical competence
Authors: F. D. Moore
Journal: JAMA (1967)

Being an Essay on the Importance, Opportunity, Urgency and Occasionally Inadequacy of the Undergraduate Surgical Curriculum, Written Particularly for the Perusal of Highly Placed Persons in the Offices of Deans, Department of Internal Medicine, and Committees Established for the Rearrangement of the Curriculum as well as for Certain Others who rarely come to the Operating Room while Awake.
Roles of prostaglandin production and mitogen-activated protein kinase activation in hepatocyte growth factor?mediated rat hepatocyte proliferation*1
Authors: T ADACHI
Journal: Hepatology (1995)

Hepatocyte growth factor (HGF) and epidermal growth factor (EGF)-stimulated DNA synthesis in primary cultured rat hepatocytes. HGF-induced DNA synthesis was concentration-dependently inhibited by a cyclooxygenase inhibitor, indomethacin. BW755C, a dual inhibitor for cyclooxygenase and lipoxygenase activities, also inhibited hepatocyte growth. Prostaglandin E1 (PGE1), PGE2, and PGF2α induced DNA synthesis even at such a low concentration as 5 nmol/L and potentiated [3H] thymidine incorporation induced by HGF in an additive manner. HGF caused arachidonic acid (AA) release and eicosanoid production. These events were detectable within 10 minutes after stimulation and lasted for at least 60 minutes. Furthermore, two proteins with approximately 40 kd were tyrosine phosphorylated by HGF. These proteins were identified as p42/p44 mitogenactivated protein (MAP) kinases by anti-MAP kinase immunoblots, which were known to activate cytosolic phospholipase A2 (cPLA2), a key enzyme in AA release. Activation of MAP kinases was detectable within 5 minutes after stimulation with HGF and lasted for at least 60 minutes. EGF-mediated DNA synthesis was also inhibited by the above cyclooxygenase inhibitors. EGF caused AA release and tyrosine phosphorylation of MAP kinases. These results suggest that HGF as well as EGF causes AA release, probably through activation of cPLA2 mediated by MAP kinases, and that PGs, metabolites of AA, might play a pivotal role in hepatocyte proliferation in an autocrine mechanism.
Ectopic pregnancy and reproductive technology
Authors: R. N. Taylor
Journal: JAMA (1988)

The frequency of ectopic pregnancy has approximately tripled in each of the last two decades<sup>1,2</sup>and is currently See also p 1823. reaching epidemic proportions in the United States and the United Kingdom.<sup>3</sup>At the University of California, San Francisco, Hospitals, the rate of ectopic pregnancy has paralleled this trend, increasing from one per 123 live births to one per 36 live births during the past ten years.<sup>4</sup>As in other epidemics, physicians and public health professionals have two primary responsibilities: (1) to provide timely and effective care to women afflicted with tubal pregnancy and (2) to ascertain the causes of this escalating problem, so that appropriate preventive measures can be instituted to eradicate this fertility-compromising and potentially life-threatening condition. The responsibilities of physicians were summarized perceptively by Dr Bernard Rieux, the narrator of Camus' classic novel,<i>The Plague</i>, who dispassionately and selflessly battled a plague epidemic
Uncertainty rounds
Authors: M. L. Cohen
Journal: JAMA (1983)

A cartoon on the bulletin board of our medical school classroom showed a well-dressed physician sitting behind an enormous desk in front of a diploma-filled wall. He was on the telephone, and with a somewhat puzzled expression said: "I'm sorry... could you put that into the form of a multiple-choice question?" Even as freshmen we appreciated the irony. But now, comparing the lessons of medical school to the realities of clinical practice, I believe this response may be related to the skepticism toward physicians that has been evident in popular publications and is bemoaned in the medical press. Physicians are not adequately prepared to deal with uncertainty; yet uncertainty is everywhere in medicine. Like the cartoon doctor, we all were taught as students that the modus operandi of the physician is to collect data, to reflect on and analyze those data, and to arrive at "The Answer." In the basic
Abstract 28: African American Race is Not Protective Against Coronary Artery Involvement in Kawasaki Disease
Authors: Emily P Williams, Michael S Kelleman, William T Mahle
Journal: Circulation (2015)

It has been previously reported that African American race may be protective against coronary artery aneurysm development in Kawasaki Disease (KD). We aimed to test this with our own cohort of KD patients from a large pediatric cardiology practice. Data from 250 subjects diagnosed with KD and followed as outpatients with surveillance echocardiography over a two-year period were analyzed. Twelve patients were excluded due to incomplete records or an unconfirmed diagnosis. Race designated by parent was recorded. Charts were reviewed for any coronary involvement (ectasia or aneurysm) and coronary Z-score greater than 2.5 at the time of diagnosis and at subsequent follow-up visits. Odds rations were calculated comparing each racial group to others for any coronary involvement and for coronary Z-score &gt; 2.5. Of 238 included patients, 44.5% were African American, 37.4% were non-Hispanic white, 10.5% were Hispanic, and 7.6% identified with other racial designations. Approximately 21.9% of African American patients had any coronary involvement and 9.5% had a coronary Z-score &gt; 2.5. Approximately 21.4% of non-Hispanic whites had any coronary involvement and 13.5% of non-Hispanic whites had a coronary Z-score &gt; 2.5. Twenty-eight percent of Hispanic patients had any coronary involvement and 12% had a coronary Z-score &gt; 2.5%. Of patients that identified with other racial designations, 38.9% had coronary involvement and 22.2% had a coronary Z-score &gt; 2.5. No statistically significant odds ratios were identified. Relative to reference group (non-Hispanic whites) African American patients had nearly identical rates of 1) any coronary involvement, or 2) coronary Z-score &gt; 2.5. KD occurs commonly in African-American children. Given equal risk for late coronary sequelae vigilance and strict adherence to consensus guidelines is essential.
Correction: Durable Carcinoembryonic Antigen (CEA)-Specific Humoral and Cellular Immune Responses in Colorectal Carcinoma Patients Vaccinated with Recombinant CEA and Granulocyte/Macrophage Colony-Stimulating Factor
Authors: Gustav J. Ullenhag, Jan-Erik Frödin, Mahmood Jeddi-Tehrani, Niklas Lidströmer, Karin Strigård, Emma Eriksson, Ali Samanci, Aniruddha Choudhury, Bo Nilsson, Eva D. Rossmann, Szilvia Mosolits, Håkan Mellstedt
Journal: Clinical Cancer Research (2019)

In the original version of this article (1), author Niklas Lidströmer is mistakenly omitted from the author list. This error has been corrected in the latest online PDF version of the article. The authors regret this error.
BACKWARD CHILDREN AND EDUCATIONAL TECHNIC.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Monitoring Metal Concentrations in Tissues and Single Cells Using Ultramicrosensors
Authors: Tadeusz Malinski, Saul Grunfeld, Ziad Taha, Paul Tomboulian
Journal: Environmental Health Perspectives (1994)

Intercellular and extracellular metal concentrations were measured using carbon fiber ultramicrosensors plated with mercury or with polymeric por- phyrinic p-type semiconductors.Concentrations of unbound nickel and lead ions were studied within individual BC3H-1 myocytes, and H4-1 1-C3 rat hepatoma cells.Unbound ions are predominantly solvated inorganic ions not coordinated to biological cellular components.Fabrication of ultramicro- sensors appropriate for the cells under investigation is described, including procedures for sharpening and waxing the microsensors in order to con- trol the shape, area, and dimensions of the electroactive surface.Metal ion movement through cell membranes and intracellular ion diffusion in aorta tissue were studied.
Genetic Justice
Authors: Mark A. Rothstein
Journal: New England Journal of Medicine (2005)

Interview with Professor Mark A. Rothstein on the use of DNA evidence to exonerate innocent prisoners. (07:20)Download On December 21, 2004, Brandon Moon was released from prison in El Paso, Texas, after having served 16 years of a 75-year sentence for three counts of aggravated sexual assault. Moon, who was 43 years of age at the time of his release, had been convicted in 1988 on the testimony of the three victims, who had had only a fleeting or partial view of their assailant. In 2004, after undergoing DNA testing, Moon was excluded as the contributor of the DNA collected after all three rapes. As a result, Moon became the 154th person in the United States to . . .
Correction: Dogs that bite
Journal: BMJ (1992)

care, the number of patients who are assigned to aggressive ambition and hence loses many with the government have offered the following, which generalists is far lower than the number Marsh more caring qualities, an emphasis that the women is what every junior doctor wants?proposes.Thus Marsh's statement that what in our care would doubtless reverse.In addressing(1) Non-medical staff trained to carry out should be done can be done in half the number of these problems the college must clarify its attitude phlebotomy, intravenous drug administration, visits is not supported by the American experience, to research and ensure that training can be electrocardiography, portering, and routine We have half the number of visits, twice the cost completed within the NHS.clerical work and to find empty beds.for the same level of care, and far less effective DAVID HOWE(2) Overtime pay equal to daytime rates.prevention than in the United Kingdom.Department of Obstetrics and Gynaecology, (3) A half day off work after a busy night on call.General practice in Britain is, with all of its Princess Anne Hospital, The government's failure to implement these faults, a model of efficient, personalised, accessible Suthampton S09 4HA demands boldly and swiftly indicates a brutality care compared with what is available in other IButSTringnobercs M71930146(7
Periodontal Disease
Authors: Ray C. Williams
Journal: New England Journal of Medicine (1990)

PERIODONTAL disease is a general term used to describe specific diseases that affect the gingiva and the supporting connective tissue and alveolar bone, which anchor the teeth in the jaws. The periodontal diseases are among the most common chronic disorders that have plagued humans for centuries. The ancient writings of Egyptian and Chinese scholars describe in great detail afflictions of the periodontal structures and how to treat them.1 Early in this century periodontal disease became popularly known as pyorrhea, a term that denoted pus, periodontal pockets, loss of bone, and loss of teeth. Pyorrhea was thought to be inevitable, and . . .
Gram-negative bacteremic shock: mechanisms and management
Authors: E. Blair
Journal: JAMA (1969)

In recent years considerable information has been gained with respect to both a better understanding of mechanisms in shock and in its management. Bacteremic shock continues to be a predominant problem in the hospital with 66% being of the gram-negative variety.<sup>1</sup>Although the Figure deals with surgical patients primarily, bacteremic shock is more prevalent and serious in medical patients (Table 1). The urinary tract is the most common source of bacteremia, but in recent years the lungs have become increasingly important (Table 1). The predominant cause of bacteremia is<i>Escherichia coli</i>; patients with bacteremia due to this microorganism have a low incidence of shock and the lowest mortality. Bacteremia from<i>Pseudomonas aeruginosa</i>has been rising in incidence and carries the gravest prognosis (Table 1). Twenty patients who had been under treatment elsewhere in the hospital were referred to the study unit with a clinical diagnosis of advanced or refractory
KERATOCONJUNCTIVITIS AS A DIAGNOSTIC AID IN MEASLES
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gold rings permanently fix artificial body parts
Authors: L. S. Zahn
Journal: JAMA (1983)

In what is believed to be the first case of its kind, a dental surgeon has used tiny gold rings to permanently attach a life-like artificial nose to the face of a cancer patient. The relatively simple surgical procedure was developed by Ariyadasa Udagama, DDS, MSD, who says he believes it also can be used on other persons who have lost facial or other body parts from illness or injury. Udagama, associate professor of dental oncology at the University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, first tried the procedure last summer on a 46-year-old woman who had lost her nose to cancer two years previously. She had been wearing an artificial nose that had to be attached daily with an adhesive. Using local anesthesia, Udagama attached a silicone nose prosthesis by simply "suturing" it to the patient's remaining tissue with small gold rings. The rings differ
What if Americans ate less fat? A quantitative estimate of the effect on mortality
Authors: W. S. Browner
Journal: JAMA (1991)

Americans consume an average of 37% of their energy intake as fat. Many authorities recommend restricting fat intake to 30% of energy intake to reduce the rates of coronary heart disease and perhaps of cancers of the breast, colon, and prostate. Based on the assumptions that underlie those recommendations, we estimated the effect of this dietary change on mortality. If all Americans restricted their intake of dietary fat by reducing consumption of saturated fat and accompanying dietary cholesterol, the corresponding reductions in serum cholesterol levels could reduce coronary heart disease mortality rates by 5% to 20%, depending on age. If the relationship between dietary fat and cancer is as strong as has been observed in some studies, the proportional effects on mortality from fat-related cancers could be even greater, although the absolute effects—given the lower mortality rates—would be smaller. Overall, if the assumptions are correct, about 42 000 of the 2.3 million deaths that would have occurred in adults each year in the United States could be deferred. This 2% benefit, equivalent to an increase in average life expectancy of 3 to 4 months, would accrue chiefly to people over the age of 65 years. If recent concerns about the possibly harmful effects of cholesterol lowering on mortality from noncardiovascular causes— which mainly affect younger persons—are valid, these relatively modest benefits would be overestimates of the actual effect. (<i>JAMA</i>. 1991;265:3285-3291)
PRO BONO PUBLICO.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Subscription Rates for JNCI
Journal: JNCI Journal of the National Cancer Institute (1973)

Journal Article New Subscription Rates for JNCI Get access JNCI: Journal of the National Cancer Institute, Volume 50, Issue 2, February 1973, Page 581, https://doi.org/10.1093/jnci/50.2.581-a Published: 01 February 1973
Prediction of response during interferon alfa 2b therapy in chronic hepatitis C patients using viral and biochemical characteristics: A comparison
Authors: M Tong
Journal: Hepatology (1997)

Patients with chronic hepatitis C (n = 103) were treated for 24 weeks with interferon alfa 2b and followed up for 24 weeks after cessation of therapy (week 48). When hepatitis C virus (HCV) RNA at week 48 was used to assess interferon response, 15 (14.6%) were virological complete responders, and all have remained HCV RNA negative for a mean of 3 years. At week 48, 3 of 15 virological complete responders had elevated alanine transaminase (ALT) values. When serum ALT level was used at week 48 to determine response to interferon, 20 (19.4%) were biochemical complete responders. However, 8 of the 20 patients with normal ALT levels were HCV RNA positive at week 48, and 7 of these individuals have had a recurrence of elevated ALT levels within 3 years after cessation of treatment. These findings indicate that measurement of HCV RNA was more accurate than ALT in determining true responses to interferon therapy. Identification of nonresponders early during the course of interferon treatment showed that an elevated ALT level at week 12 was 92% predictive (odds ratio 3.7) but misidentified 33% (5 of 15) of the patients who were virological complete responders at week 48. In contrast, a positive HCV RNA at week 12 of treatment was 98% predictive (odds ratio 35.5) and misidentified only 6.7% (1 of 15) of the virological complete responders. Thus, positive HCV RNA at week 12 of therapy was more accurate in identifying eventual virological nonresponders than measurement of ALT at this time. Termination of interferon therapy in patients who were HCV RNA positive at week 12 would result in a 27% reduction in the direct medical costs and keep patients from undergoing unnecessary treatment. Therefore, testing for HCV RNA at week 12 to identify nonresponders and then discontinuing their treatment is practical, cost-efficient and beneficial both to patients and to third-party payers.
Travaux du laboratoire de thérapeutique expérimentale de l'Universite de Genève. Années 1923-1929, XII.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal