tbuckley/cabot-search huggingface dataset:
Internal Medicine
Authors: Suzanne W. Fletcher
Journal: JAMA (1989)

Making health promotion and disease prevention a clinical activity based on medical science is one of the most important developments in general internal medicine in the past few years. The US Preventive Services Task Force, working with the Canadian Task Force on the Periodic Health Examination, has outlined criteria for determining the appropriateness of screening for medical conditions.<sup>1,2</sup>These criteria include the effectiveness of subsequent treatment if a condition is found, the burden of suffering caused by the condition, and the quality of the screening test. Preventive activities range from simple primary interventions (eg, onetime immunizations) to recurring secondary interventions (eg, breast cancer screening) to more complex interventions that require ongoing efforts by clinicians and patients (eg, smoking cessation). The scientific evidence needed to justify a clinical intervention varies with each type of prevention. Finally, research has begun to determine what physicians can do to promote health by helping
Index of Subjects
Journal: Circulation Research (1958)

policies, 671 applications for research support, 540 Arteriosclerosis (Society meeting, 133, 672 awards presented, 831 Gold Heart awards, S31 Lasker award, 831 Blood Pressure Council elects officers, 134 calculus course in Elaine, 398 films on cardiovascular system, 832 on research careers, 832 fund for fellowships and giants, 543 fund policy,
Instructions to Authors
Journal: Circulation Research (1971)

Circulation Research accepts for publication manuscripts that present the results of significant research on the cardiovascular and renal systems.First priority is given to unpublished research that provides better understanding of mechanisms that influence normal or abnormal cardiovascular-renal function.The research may be in the field of biology, biochemistry, biophysics, clinical medicine, genetics, immunology, morphology, pathology, pharmacology, physiology, or theoretic biology-or it may be interdisciplinary.Lower priority is given to reports that merely confirm published work, that present a new method or modification of an existing method without applying it to a biologic problem, or that are preliminary or incomplete.Since the number of papers that can be published each year is limited, only manuscripts that receive a relatively high priority can be accepted for publication.One complete long manuscript is preferred to several fragmented, interdependent manuscripts.
Abstract 3427: Uncoupling of Skeletal Muscle Perfusion and Metabolism in Peripheral Arterial Disease
Authors: Justin D Anderson, Frederick H Epstein, Craig H Meyer, Klaus D Hagspiel, Hongkun Wang, Stuart S Berr, Nancy L Harthun, Arthur L Weltman, David C Isbell, Patrick T Norton, Christopher M Kramer
Journal: Circulation (2007)

Introduction Studies suggests that limb hemodynamics do not correlate with functional capacity in patients with peripheral arterial disease (PAD). Alterations in microcirculatory function and muscle metabolism are postulated to account for part of this inconsistency. We sought to further characterize the relationship between macrovascular obstruction, tissue perfusion and cellular metabolism in patients with PAD. Methods Sixty-two patients with mild-to-moderate PAD (35 males, mean age±S.D. 65±11 years) had their most symptomatic leg studied (resting ankle-brachial index (ABI) 0.68±0.13). To assess macrovascular disease, a runoff magnetic resonance angiogram was segmentally scored (MRAi) according to the number and degree of arterial stenoses distal to the aorta. A calf muscle perfusion index (PI) was measured at peak exercise with a magnetic resonance imaging (MRI) compatible pedal ergometer using first pass gadolinium-enhanced MRI. PI was defined as the ratio of slopes of calf muscle tissue perfusion to arterial input. 31 Phosphorus MR spectroscopy measured calf muscle phosphocreatine recovery time constant (PCr) immediately after peak exercise. Correlations between ABI, MRAi, PI, and PCr were examined by Pearson’s correlation coefficient. Results Mean MRAi was 0.97±0.74, PI was 0.45±0.15, and PCr was 73.1±30.0 sec. For reference, values in normal subjects are 0, 0.69±0.17 and 34.7±16.6 sec, respectively. The ABI correlated with PI (r=0.46, p&lt;0.001), inversely with MRAi (r=−0.39, p&lt;0.005) and modestly inversely with PCr (r=−0.27, p = 0.05). The MRAi showed a trend towards an inverse correlation with PI (r=−0.27, p&lt;0.06), but did not correlate with PCr (p = 0.29). PCr likewise did not correlate with PI (p=0.85). Conclusions In mild to moderate PAD, lower limb blood pressure relates to macrovascular obstruction and both calf muscle perfusion and metabolism at peak exercise. However, calf muscle perfusion does not correlate with cellular metabolism as determined by PCr recovery at peak exercise. Thus, there is uncoupling between calf muscle perfusion and metabolism, supporting the concept that factors independent of blood flow and intrinsic to skeletal muscle are critical in PAD.
Asklepios
Authors: Manuel Cooper
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the Joint Commission on Accreditation of Healthcare Organizations
Authors: J. M. Loeb
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deaths, Morbidity Not Reduced Thus Far, Oregon Study Shows
Journal: JAMA (1964)

To determine the measurable value of long-term anticoagulant therapy after myocardial infarction, four physicians at the University of Oregon Medical School in Portland instituted a controlled double-blindfold study seven years ago. That study is still in progress, and to date has involved 200 patients. Although a final report is not yet being considered, the principal investigator, Arthur J. Seaman, MD, presented a progress report at the International Symposium on Anticoagulants at Miami Beach last month. His observations on the experiment: "As yet no reduction in death rate or overall decrease in morbidity has been shown to be conferred by continuous prophylactic anticoagulant therapy post-myocardial infarction." Seaman, whose colleagues include Herbert E. Griswold, MD, Balph B. Beaume, MD, and Leonard W. Ritzmann, MD, said the trend of the results after sequential analysis has moved in the direction of the as yet unreached conclusion that there is "no difference between anticoagulant therapy and placebo (or control) treatment."
Patterns of care and outcomes with the addition of radiotherapy to surgery for stage I rectal adenocarcinoma.
Authors: Nan Zhao, Chi Lin
Journal: Journal of Clinical Oncology (2018)

831 Background: The standard of care for stage I (T1/2N0M0) rectal adenocarcinoma is surgery alone. We investigated practice patterns and outcomes associated with administration of radiotherapy (RT) to surgery for stage I rectal adenocarcinoma. Methods: Using National Cancer Database from 2004 to 2014, 12494 patients with clinical stage T1-2N0M0 rectal adenocarcinoma who had definitive surgery were analyzed. 8265 received definitive surgery alone and 4229 received definitive surgery with preoperative or postoperative RT. Between groups, demographic, tumor and treatment characteristics were compared. Multivariate logistics regression was used to examine factors associated with the receipt of RT. Overall survival (OS) were estimated by Kaplan-Meier method; the log-rank test was used to compare survival curves. Cox proportional hazards modeling determined variables associated with death. Results: Of 12494 patients, 34% received RT; among them, 94% received chemotherapy (CT). Patients who received RT tended to be younger, male, diagnosed in early years, covered by Medicaid/Medicare/Not Insured, treated at community cancer program, a lower Charlson/Deyo score, a T2 clinical stage, a poorly differentiated or a larger tumor. Survival analysis revealed no difference in patients with or without RT (Median survival of 142 months vs. 137 months and 5 year OS of 79% vs. 82%, p = 0.50). Multivariate Cox models showed that variables significantly associated with increased hazard of death (p &lt; 0.05) were older age (HR = 1.06), male gender (HR = 1.24) , Charlson/Deyo score 1 (HR = 1.54)/ Charlson/Deyo score 2 (HR = 2.29) (vs. Charlson/Deyo score 0), clinical T2 stage (HR = 1.15), pathological III/IV stage (HR = 4.16), poorly differentiated grade (HR = 1.38), Medicaid (HR = 1.70) /Medicare (HR = 1.24) /Not Insured (HR = 2.28) (vs. private insurance), community cancer program (HR = 1.17) and lower income (HR = 1.25). After adjusting for all above variables, RT or CT was not associated with improved OS. Conclusions: Addition of RT (with or without chemotherapy) to definitive surgery was not associated with survival advantage in stage I rectal adenocarcinoma.
Why Physician Leaders of Health Care Organizations Should Participate in Direct Patient Care
Authors: Allan S. Detsky, Michael A. Gropper
Journal: Annals of Internal Medicine (2017)

Letters7 March 2017Why Physician Leaders of Health Care Organizations Should Participate in Direct Patient CareAllan S. Detsky, MD, PhD and Michael A. Gropper, MD, PhDAllan S. Detsky, MD, PhDFrom University of Toronto, Toronto, Ontario, Canada, and University of California, San Francisco, San Francisco, California.Search for more papers by this author and Michael A. Gropper, MD, PhDFrom University of Toronto, Toronto, Ontario, Canada, and University of California, San Francisco, San Francisco, California.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L16-0624 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:As we stated in our commentary, we expected that physicians who chose to continue performing direct patient care during their tenure as leaders would agree with our position and those who did not make the same choice would not agree. The comments we see here (and others sent to us directly) reflect this bias. We acknowledged our own bias in our commentary, as well.We agree with Dr. Channin that chief executive officers may not be able to find a clinical niche in which they can practice safely. But there are also ways to be present in the ... Author, Article, and Disclosure InformationAffiliations: From University of Toronto, Toronto, Ontario, Canada, and University of California, San Francisco, San Francisco, California.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M16-0820. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoWhy Physician Leaders of Health Care Organizations Should Participate in Direct Patient Care Allan S. Detsky and Michael A. Gropper Why Physician Leaders of Health Care Organizations Should Participate in Direct Patient Care David S. Channin Why Physician Leaders of Health Care Organizations Should Participate in Direct Patient Care Richard Rohr Metrics 7 March 2017Volume 166, Issue 5Page: 376-377KeywordsBehaviorConflicts of interestDisclosureHealth carePatients ePublished: 7 March 2017 Issue Published: 7 March 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Letters to the Editor
Authors: M. Fani Bozkurt
Journal: Clinical Nuclear Medicine (2001)

Department of Nuclear Medicine Hacettepe University Faculty of Medicine Ankara, Turkey E-mail: [email protected] CLINICAL NUCLEAR MEDICINE publishes in each issue a section of references to articles of interest to its readers taken from the world medical literature. Articles below were selected from listings received through July 15, 2001. Slavic and Oriental language articles have English summaries unless marked with an asterisk after language abbreviation.
Diabetes and menstruation.
Journal: BMJ (1970)

MEDIAJORAL 699 ment in mortality was especially noticeable in severe first attacks and in severe episodes in patients over 60 years of age.A review of the 140 patients who survived without operation during their attacks showed that over one-third subsequently required surgical treatment either as an elective procedure or because of further attacks.Perforation of the colon was found in 21 cases (with a mortality of 28-6%).Acute colonic dilatation was observed in 28 instances; 27 were treated by emergency colectomy and perforation had occurred in eleven cases.The mortality of these operations was 18-5%.The authors point out that their results have the disadvantage of not being carried out with the rigid discipline of a controlled prospective trial, and some of the improvement that they record might in theory be due to some change in the character of the cases with severe colitis during the period under review.However, the excellence of the results now being obtained with early surgery in patients with severe colitis and its complications would cast serious ethical doubts on a prospective trial of early against late intervention.
Persistence of Polybrominated Biphenyls (PBB) in Human Post-Mortem Tissue
Authors: Joseph N. Miceli, David C. Nolan, Bernard Marks, M. Hariharan
Journal: Environmental Health Perspectives (1985)

Polybrominated biphenyl (PBB), a fire retardant, was accidentally substituted for an animal feed supplement in Michigan 10 years ago. This led to widespread livestock contamination and ultimately to contamination of virtually every human residing in the State at that time. In order to evaluate the extent of PBB persistence and distribution in human tissues 10 years after this accidental poisoning, a study was conducted on a series of autopsy cases from the Grand Rapids ("high" exposure) area of the State. No attempt was made to relate cause of death to PBB exposure or tissue concentration. Samples of 196 tissues from 15 subjects were analyzed for PBB content, and levels were determined by measurement of the hexabromobiphenyl peak using electron capture gas chromatography. Only 4 of the 196 samples analyzed did not have PBB concentration above the limit of detection (0.5 ng/g). As expected, fat and fat-rich tissue had the highest PBB concentration. Perirenal fat had the highest mean concentration (475 ng/g). Adrenal, atheromatus aorta and thymus had mean concentrations about half that of perirenal fat; all other tissues had mean concentrations one-tenth or less of perirenal fat. The results document that PBB is still present in human tissue and that PBB was distributed in all tissues examined. The PBB fat elimination half-time was estimated to be at least 7.8 years. If this is approximately correct, PBB will persist in tissues throughout the lifetime of humans so contaminated.
Navitoclax (ABT-263) Plus Fludarabine/Cyclophosphamide/Rituximab (FCR) or Bendamustine/Rituximab (BR): A Phase 1 Study In Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL)
Authors: Thomas J. Kipps, William G. Wierda, Jeffrey A. Jones, Lode J. Swinnen, Jianning Yang, Yue Cui, Todd Busman, Andrew Krivoshik, Sari Enschede, Rod Humerickhouse
Journal: Blood (2010)
Primary Myoglobinuria
Authors: Robert L. Gillett
Journal: New England Journal of Medicine (1959)

PRIMARY myoglobinuria is an interesting and, to judge by the literature, a very rare condition, characterized by acute attacks of muscular dysfunction and the passage of dark-red to brown urine. Myoglobinuria may occur in a number of conditions. Whisnant et al.,1 in 1956, classified the myoglobinurias as follows: primary myoglobinuria (similar to equine paroxysmal paralytic myoglobinuria); and secondary myoglobinuria (crush syndrome, high-voltage shock, arterial occlusion with ischemia, Haff disease, progressive muscular dystrophy [?J and myositis [?]). The secondary myoglobinurias are better known than the primary type and will not be discussed in detail in this article, but a few points . . .
Forecast of the Number of Patients with End-Stage Renal Disease in the United States to the Year 2010
Authors: Jay L. Xue, Jennie Z. Ma, Thomas A. Louis, Allan J. Collins
Journal: Journal of the American Society of Nephrology (2001)

As the United States end-stage renal disease (ESRD) program enters the new millennium, the continued growth of the ESRD population poses a challenge for policy makers, health care providers, and financial planners. To assist in future planning for the ESRD program, the growth of patient numbers and Medicare costs was forecasted to the year 2010 by modeling of historical data from 1982 through 1997. A stepwise autoregressive method and exponential smoothing models were used. The forecasting models for ESRD patient numbers demonstrated mean errors of -0.03 to 1.03%, relative to the observed values. The model for Medicare payments demonstrated -0.12% mean error. The R(2) values for the forecasting models ranged from 99.09 to 99.98%. On the basis of trends in patient numbers, this forecast projects average annual growth of the ESRD populations of approximately 4.1% for new patients, 6.4% for long-term ESRD patients, 7.1% for dialysis patients, 6.1% for patients with functioning transplants, and 8.2% for patients on waiting lists for transplants, as well as 7.7% for Medicare expenditures. The numbers of patients with ESRD in 2010 are forecasted to be 129,200 +/- 7742 (95% confidence limits) new patients, 651,330 +/- 15,874 long-term ESRD patients, 520,240 +/- 25,609 dialysis patients, 178,806 +/- 4349 patients with functioning transplants, and 95,550 +/- 5478 patients on waiting lists. The forecasted Medicare expenditures are projected to increase to $28.3 +/- 1.7 billion by 2010. These projections are subject to many factors that may alter the actual growth, compared with the historical patterns. They do, however, provide a basis for discussing the future growth of the ESRD program and how the ESRD community can meet the challenges ahead.
The Gift
Authors: A L Kennedy
Journal: Annals of Internal Medicine (1996)

On Being a Doctor15 September 1996The GiftAllan L. Kennedy, DO, PhDAllan L. Kennedy, DO, PhDWilliam Beaumont Hospital, Royal Oak, MI 48073Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-6-199609150-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Mr. Smith never complained. I first met him while I was a resident on a general medicine service to which he had been admitted for anemia. We hit it off from the start. He was a man of many interests but had never been able to achieve any major successes in his 55 years. He ran an electronics repair business from his home, and he gave me his card.After 3 days of tests and transfusions, he was discharged without a diagnosis. He returned within a few weeks. Although I was no longer involved in his care, he asked to ... Author, Article, and Disclosure InformationAuthors: Allan L. Kennedy, DO, PhDAffiliations: William Beaumont Hospital, Royal Oak, MI 48073Corresponding Author: Allan L. Kennedy, DO, PhD, 2009 Shirewood, Utica, MI 48317. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byReflections of Physician-Authors on Death: Literary Selections Appropriate for Teaching RoundsAttempting Resuscitation in Nursing Homes: Policy Considerations 15 September 1996Volume 125, Issue 6Page: 513KeywordsAnemiaBloodCardiopulmonary resuscitationChildrenEmotionsIntubationNursesResuscitationThorax ePublished: 15 August 2000 Issue Published: 15 September 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Ophthalmology Editorial Committee for 1986
Authors: Paul Henkind, Joseph Walsh, Ronald Burde, Robert Drews, Donald Hall, J Rowsey, Robert Stamper, Barbara Streeten, Thomas Weingeist, Editorial Advisors, Mathea Allansmith, Douglas Anderson, Frederick Fraunfelder, David Friendly, Brenda Gallie, David Guyton, Frederick Jakobiec, Ronald Klein, Richard Lewis, Stephen Trokel, Myron Yanoff, Jaye Henkind-Managing Editor, Lisa Marshall-Production Editor, Joan Gullusci-, Patricia Shanahan, Thomas Aaberg, David Abramson, Albert Ackerman, Daniel Albert, Richard Anderson, W Anderson, J David, Juan Apple, Penny Arentsen, Norman Asbell, Michael Ashton, Jules Barza, Bernard Baum Crowell Beard, Hugh Becker, Myles Beckman, Anders Behrens, Edwin Bill, Perry Billet, George Binder, Frederick Blankenship, Mark Blodi, Steven Blumenkranz, Deanbok Bodine, William Arthur Boruchoff, Alvin Bourne, George Brackup, Gary Bresnick, Stuart Brown, Ronald Brown, Thomas Burde, Jorge Burton, Alston Buxton
Journal: Ophthalmology (1986)