Alcoholic Hepatitis
Authors: TELFER B. REYNOLDS
Journal: Annals of Internal Medicine (1971)

Editorials1 March 1971Alcoholic HepatitisTELFER B. REYNOLDS, M.D., HUGH A. EDMONDSONTELFER B. REYNOLDS, M.D.Search for more papers by this author, HUGH A. EDMONDSONSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-3-440 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCirrhosis and fatty liver have been recognized as sequels of alcoholism for many years. Surprisingly, until recently there has been only sporadic interest in the consequences of acute hepatocyte injury produced by alcoholism. The hallmarks of this injury, as described by Helman, Temko, Nye, and Fallon in this issue of the ANNALS(pp. 311-321), are swelling and degeneration of hepatocytes, formation of alcoholic hyaline, and infiltration by polymorphonuclear leukocytes. F. B. Mallory first drew attention to this lesion in 1911 (1). Since then clinicians and pathologists have used various terms for the clinicopathologic syndrome, including "acute hepatic insufficiency of the...References1. MALLORY F: Cirrhosis of the liver. Five different types of lesions from which it may arise. Bull Johns Hopkins Hosp 22:69-75, 1911 Google Scholar2. BECKETT A, LIVINGSTONE A, and HILL K: Acute alcoholic hepatitis. Brit Med J 2:1113-1119, 1961 CrossrefMedlineGoogle Scholar3. OUDEA M, LAUNAY A, and QUENEHERVE S: The hepatic lesions produced in the rat by chronic alcoholic intoxication. Histological, ultrastructural and biochemical observations. Rev Europ Etudes Clin Biol 15:748-764, 1970 MedlineGoogle Scholar4. RUBIN E and LIEBER C: Early fine structural changes in the human liver induced by alcohol. Gastroenterology 52:1-13, 1967 CrossrefMedlineGoogle Scholar5. BECKETT A, LIVINGSTONE A, and HILL K: Acute alcoholic hepatitis without jaundice. Brit Med J 2:580-582, 1962 CrossrefMedlineGoogle Scholar6. MIKKELSEN W, TURRILL F, and KERN W: Acute hyaline necrosis of the liver. A surgical trap. Amer J Surg 116:266-272, 1968 CrossrefMedlineGoogle Scholar7. EDMONDSON H, PETERS R, and REYNOLDS T: Sclerosing hyaline necrosis of the liver. A recognizable clinical syndrome. Ann Intern Med 59:646-673, 1963 LinkGoogle Scholar8. REYNOLDS T, HIDEMURA R, and MICHEL H: Portal hypertension without cirrhosis in alcoholic liver disease. Ann Intern Med 70:497-506, 1969 LinkGoogle Scholar9. EDMONDSON H, PETERS R, and FRANKEL H: The early stage of liver injury in the alcoholic. Medicine (Balt) 46: 121-129, 1967 CrossrefGoogle Scholar10. WELLS R: Prednisolone and testosterone proprionate in cirrhosis of the liver. A controlled trial. Lancet 2:1416-1419, 1960 CrossrefMedlineGoogle Scholar11. ZOECKLER S: Cortisone in portal cirrhosis: a controlled study. Gastroenterology 26:878-886, 1954 CrossrefMedlineGoogle Scholar12. : Effect of prednisone on the survival of patients with cirrhosis of the liver. Lancet 1:119-121, 1969 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: TELFER B. REYNOLDS, M.D.; HUGH A. EDMONDSONAffiliations: University of Southern California School of Medicine Los Angeles, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byStellate cells and the “reversible component” of portal hypertensionFailure of colchicine to improve short-term survival in patients with alcoholic hepatitisDo Corticosteroids Reduce Mortality from Alcoholic Hepatitis? A Meta-analysis of the Randomized TrialsThomas F. Imperiale, MD, Arthur J. 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KIRSHBAUM, M.D., MICHEL OLIVIER, M.D., ALLAN G. REDEKER, M.D., TELFER B. REYNOLDS, M.D.Hepatic and Metabolic Effects of Alcohol (1966 to 1973)Natural History of Alcoholic Hepatitis 1 March 1971Volume 74, Issue 3Page: 440-442KeywordsAlcoholicsAlcoholismCirrhosisFatty liverHepatitisHepatocytesInflammationLesionsNeutrophilsPathologists ePublished: 1 December 2008 Issue Published: 1 March 1971 PDF downloadLoading ...