tbuckley/cabot-search huggingface dataset:
Annals Graphic Medicine - Five Senses of Medicine
Authors: Oscar Li
Journal: Annals of Internal Medicine (2022)

Web ExclusivesOctober 2022Annals Graphic Medicine - Five Senses of MedicineFREEOscar Li, BSOscar Li, BSJohns Hopkins University School of Medicine, Baltimore, Maryland (O.L.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G22-0014 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Download figure Download PowerPoint Download figure Download PowerPoint Download figure Download PowerPoint Download figure Download PowerPoint Download figure Download PowerPoint Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment Jose CarvalloUniversidad de Panamá - Caja de Seguro Social2 October 2022 A must for medical students These drawings must be used in physical diagnosis lectures. Neat and precise, these images transport you to the encounter with the patient(i.e. smell), yet briefly convey you to do your work, explore and heal. Author, Article, and Disclosure InformationAffiliations: Johns Hopkins University School of Medicine, Baltimore, Maryland (O.L.)Disclosures: The author has reported no disclosures of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G22-0014.Author/Illustrator Information: Oscar Li, BS, is an award-winning filmmaker and second-year medical student at the Johns Hopkins University School of Medicine (e-mail, [email protected]com; website, www.onlyoscarli.com).This article was published at Annals.org on 27 September 2022. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics October 2022Volume 175, Issue 10Page: W136-W142 ePublished: 27 September 2022 Issue Published: October 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Evaluation of Harms Reporting in U.S. Cancer Screening Guidelines
Authors: Aruna Kamineni, V. Paul Doria-Rose, Jessica Chubak, John M. Inadomi, Douglas A. Corley, Jennifer S. Haas, Sarah C. Kobrin, Rachel L. Winer, Jennifer Elston Lafata, Elisabeth F. Beaber, Joshua S. Yudkin, Yingye Zheng, Celette Sugg Skinner, Joanne E. Schottinger, Debra P. Ritzwoller, Jennifer M. Croswell, Andrea N. Burnett-Hartman
Journal: Annals of Internal Medicine (2022)

Cancer screening should be recommended only when the balance between benefits and harms is favorable. This review evaluated how U.S. cancer screening guidelines reported harms, within and across organ-specific processes to screen for cancer.
Levelling up prevention in primary care
Authors: Laura Heath, Brian Nicholson, Paul Aveyard
Journal: BMJ (2022)

Much of what we do in primary care is prevention.We diagnose and manage hypertension, reduce cholesterol, optimise diabetes care, and initiate anticoagulation in atrial fibrillation.All of these are preventative interventions in patients who are largely asymptomatic.By embracing these preventative activities, we endorse them as a worthwhile use of clinician time.
Population-Based Recalibration of the Framingham Risk Score and Pooled Cohort Equations
Authors: Maneesh Sud, Atul Sivaswamy, Anna Chu, Peter C. Austin, Todd J. Anderson, David M.J. Naimark, Michael E. Farkouh, Douglas S. Lee, Idan Roifman, George Thanassoulis, Karen Tu, Jacob A. Udell, Harindra C. Wijeysundera, Dennis T. Ko
Journal: Journal of the American College of Cardiology (2022)
Hemodynamic and Clinical Performance of Hearts Donated After Circulatory Death
Authors: David A. D’Alessandro, Stanley B. Wolfe, Asishana A. Osho, Kamila Drezek, Monica N. Prario, S. Alireza Rabi, Eriberto Michel, Lana Tsao, Erin Coglianese, Meaghan Doucette, Daniel A. Zlotoff, Christopher Newton-Cheh, Sunu S. Thomas, Van-Khue Ton, Nilay Sutaria, Mark W. Schoenike, Anastasia M. Christ, Dane C. Paneitz, Mauricio Villavicencio, Joren C. Madsen, Richard Pierson, Gregory D. Lewis
Journal: Journal of the American College of Cardiology (2022)
Aspirin for Primary Prevention of Cardiovascular Events in Relation to Lipoprotein(a) Genotypes
Authors: Paul Lacaze, Andrew Bakshi, Moeen Riaz, Galina Polekhina, Alice Owen, Harpreet S. Bhatia, Pradeep Natarajan, Rory Wolfe, Lawrence Beilin, Stephen J. Nicholls, Gerald F. Watts, John J. McNeil, Andrew M. Tonkin, Sotirios Tsimikas
Journal: Journal of the American College of Cardiology (2022)
Evolution of the joint International Atomic Energy Agency (IAEA), International Agency for Research on Cancer (IARC), and WHO cancer control assessments (imPACT Reviews)
Authors: Igor Veljkovikj, André M Ilbawi, Felipe Roitberg, Silvana Luciani, Prebo Barango, Marilys Corbex, Gampo Dorji, Nalika Gunawardena, Sonali Johnson, Arsen Juric, Kendall Siewert, Giovanni Saporiti, Marianna Nobile, Catherine Sauvaget, Janaki Vidanapathirana, Beverley Wright, Kennedy Lishimpi, Dilyara Kaidarova, Alicia Pomata, Anne Malick, Jean Marie Dangou, May Abdel-Wahab, Elisabete Weiderpass, Bente Mikkelsen, Lisa M Stevens
Journal: The Lancet Oncology (2022)
European Society for Radiotherapy and Oncology and European Organisation for Research and Treatment of Cancer consensus on re-irradiation: definition, reporting, and clinical decision making
Authors: Nicolaus Andratschke, Jonas Willmann, Ane L Appelt, Najlaa Alyamani, Panagiotis Balermpas, Brigitta G Baumert, Coen Hurkmans, Morten Høyer, Johannes A Langendijk, Orit Kaidar-Person, Yvette van der Linden, Icro Meattini, Maximilian Niyazi, Nick Reynaert, Dirk De Ruysscher, Stephanie Tanadini-Lang, Peter Hoskin, Philip Poortmans, Carsten Nieder
Journal: The Lancet Oncology (2022)
Make the entrance wider and the depth deeper
Authors: Hiroyuki Isayama
Journal: Endoscopy (2022)

The use of artificial intelligence (AI) in medicine is under active investigation. In recent years, AI tools have emerged that require little or no operator training; these are increasingly being used in the clinic. Indeed, advances in imaging diagnostics, as well as automatic diagnosis using radiography and three-dimensional images that do not require human intervention or operation are being put to use [1]. AI may perform the functions of physicians in various fields.
Correction: Endoscopy-assisted magnetic compression anastomosis for rectal anastomotic atresia
Authors: Guifang Lu, Jing Li, Mudan Ren, Feng Ma, Xuejun Sun, Yi Lv, Shuixiang He
Journal: Endoscopy (2021)

Correction to: Endoscopy-assisted magnetic compression anastomosis for rectal anastomotic atresiaEndoscopy 2021; 53(12): E437-E439DOI: 10.1055/a-1322-1899
Incidence of death or disability at 6 months after extracorporeal membrane oxygenation in Australia: a prospective, multicentre, registry-embedded cohort study
Authors: Carol L Hodgson, Alisa M Higgins, Michael J Bailey, Shannah Anderson, Stephen Bernard, Bentley J Fulcher, Denise Koe, Natalie J Linke, Jasmin V Board, Daniel Brodie, Heidi Buhr, Aidan J C Burrell, D James Cooper, Eddy Fan, John F Fraser, David J Gattas, Ingrid K Hopper, Sue Huckson, Edward Litton, Shay P McGuinness, Priya Nair, Neil Orford, Rachael L Parke, Vincent A Pellegrino, David V Pilcher, Jayne Sheldrake, Benjamin A J Reddi, Dion Stub, Tony V Trapani, Andrew A Udy, Ary Serpa Neto
Journal: The Lancet Respiratory Medicine (2022)
A survey on the patient perspective on cure in multiple myeloma
Authors: Ghulam Rehman Mohyuddin, Jennifer M Ahlstrom, Cindy A Chmielewski, Nathan W Sweeney, Thomas H Molina, Christian S Cheung, Emily Watabe Ballard, Felicia F Seng, Oliver Van Oekelen, Amandeep Godara, Brian McClune, Douglas Sborov
Journal: The Lancet Haematology (2022)
Antimalarial chemoprophylaxis for forest goers in southeast Asia: an open-label, individually randomised controlled trial
Authors: Rupam Tripura, Lorenz von Seidlein, Siv Sovannaroth, Thomas J Peto, James J Callery, Meas Sokha, Mom Ean, Chhouen Heng, Franca Conradis-Jansen, Wanassanan Madmanee, Pimnara Peerawaranun, Naomi Waithira, Panarasri Khonputsa, Monnaphat Jongdeepaisal, Kulchada Pongsoipetch, Paphapisa Chotthanawathit, Ung Soviet, Christopher Pell, Jureeporn Duanguppama, Huy Rekol, Joel Tarning, Mallika Imwong, Mavuto Mukaka, Nicholas J White, Arjen M Dondorp, Richard J Maude
Journal: The Lancet Infectious Diseases (2022)

Malaria in the eastern Greater Mekong subregion has declined to historic lows. Countries in the Greater Mekong subregion are accelerating malaria elimination in the context of increasing antimalarial drug resistance. Infections are now increasingly concentrated in remote, forested foci. No intervention has yet shown satisfactory efficacy against forest-acquired malaria. The aim of this study was to assess the efficacy of malaria chemoprophylaxis among forest goers in Cambodia.
Accuracy of self-assessment in gastrointestinal endoscopy: a systematic review and meta-analysis
Authors: Michael A. Scaffidi, Juana Li, Shai Genis, Elizabeth Tipton, Rishad Khan, Chandni Pattni, Nikko Gimpaya, Glyneva Bradley-Ridout, Catharine M. Walsh, Samir C. Grover
Journal: Endoscopy (2022)

Background Assessment is necessary to ensure both attainment and maintenance of competency in gastrointestinal (GI) endoscopy, and this can be accomplished through self-assessment. We conducted a systematic review with meta-analysis to evaluate the accuracy of self-assessment among GI endoscopists. Methods This was an individual participant data meta-analysis of studies that investigated self-assessment of endoscopic competency. We performed a systematic search of the following databases: Ovid MEDLINE, Ovid EMBASE, Wiley Cochrane CENTRAL, and ProQuest Education Resources Information Center. We included studies if they were primary investigations of self-assessment accuracy in GI endoscopy that used statistical analyses to determine accuracy. We conducted a meta-analysis of studies using a limits of agreement (LoA) approach to meta-analysis of Bland–Altman studies. Results After removing duplicate entries, we screened 7138 records. After full-text review, we included 16 studies for qualitative analysis and three for meta-analysis. In the meta-analysis, we found that the LoA were wide (−41.0 % to 34.0 %) and beyond the clinically acceptable difference. Subgroup analyses found that both novice and intermediate endoscopists had wide LoA (−45.0 % to 35.1 % and −54.7 % to 46.5 %, respectively) and expert endoscopists had narrow LoA (−14.2 % to 21.4 %). Conclusions GI endoscopists are inaccurate in self-assessment of their endoscopic competency. Subgroup analyses demonstrated that novice and intermediate endoscopists were inaccurate, while expert endoscopists have accurate self-assessment. While we advise against the sole use of self-assessment among novice and intermediate endoscopists, expert endoscopists may wish to integrate it into their practice.
Unfettered economic growth will destroy us: we need an alternative
Authors: Richard Smith
Journal: BMJ (2022)

Economic growth is supposed to save Britain, but sadly it's more likely to destroy us.Growth as the central concern of economics is, points out Geoff Mann in the London Review of Books, a relatively recent phenomenon. 1 Adam Smith never mentioned it, and one of the main Bibles of growth, Stages of Economic Growth: A Non-Communist Manifesto by Walt Rostow, was published in 1960.Growth was the answer to the Great Depression, the Cold War, domestic instability, and decolonisation.It was also an antidote to redistribution of wealth: instead of dividing the cake between rich and poor the cake would be bigger, the rich could keep their cake, and everybody would have more cake.
Artificial intelligence for polyp characterization: easy as ABC
Authors: Omer F. Ahmad
Journal: Endoscopy (2022)

The concept of real-time optical diagnosis, using enhanced imaging techniques to predict histopathology, has been pursued for over a decade. Sound principles have guided this enthusiasm, with the most robust case existing for diminutive (< 5 mm) colorectal polyps, which constitute the most commonly identified and excised lesions for histopathological assessment. Abandoning histopathology, and instead relying on optical diagnosis, represents a paradigm shift, often referred to as a “resect-and-discard” strategy for diminutive adenomas and a “leave-in-situ” strategy for diminutive rectosigmoid hyperplastic polyps. This is highly attractive, considering the significant economic and environment burden of the current approach. Moreover, diminutive lesions have an extremely low risk of harboring invasive neoplasia. Owing to a number of barriers, the uptake of optical diagnosis for diminutive colorectal polyps has been poor. In particular, evidence suggests that optical diagnosis is operator-dependent, with nonexperts unable to consistently achieve the performance thresholds required.
High-Dimensional Clustering of 4000 Irritable Bowel Syndrome Patients Reveals Seven Distinct Disease Subsets
Authors: Anjali Byale, Ryan J. Lennon, Siddharth Byale, Margaret Breen-Lyles, Adam L. Edwinson, Ruchi Gupta, Brian E. Lacy, Janet E. Olson, Lesley A. Houghton, Madhusudan Grover
Journal: Clinical Gastroenterology and Hepatology (2022)
Author correction to ‘Multifunctional regulatory protein connective tissue growth factor (CTGF): A potential therapeutic target for diverse diseases’ [Acta pharmaceutica sinica B 12 (2022) 1740–1760]
Authors: Minyang Fu, Dandan Peng, Tianxia Lan, Yuquan Wei, Xiawei Wei
Journal: Acta Pharmaceutica Sinica B (2022)
Cyr61 Induces Gastric Cancer Cell Motility/Invasion via Activation of the Integrin/Nuclear Factor-κB/Cyclooxygenase-2 Signaling Pathway
Authors: Ming-Tsai Lin, Chung-Yaou Zuon, Cheng-Chi Chang, Szu-Ta Chen, Chih-Ping Chen, Been-Ren Lin, Ming-Yang Wang, Yung-Ming Jeng, King-Jen Chang, Po-Huang Lee, Wei-Jao Chen, Min-Liang Kuo
Journal: Clinical Cancer Research (2005)

Abstract Purpose: Cysteine-rich 61 (Cyr61/CCN1) is involved in many different types of tumor development and progression. Nonetheless, the role of Cyr61 in human gastric cancer has not yet been fully characterized. Experimental design: We addressed the issue by immunohistochemical staining of 81 gastric adenocarcinoma specimens. Liposome-mediated transfection was used to introduce a Cyr61 expression vector into gastric cancer AGS cell lines. Transfectants were tested in invasion assay by a Boyden chamber. Furthermore, a cyclooxygenase-2 (COX-2) reporter assay and gel mobility shift assay were done to investigate the potential signal pathway of Cyr61. Results: Patients with gastric adenocarcinoma whose tumor displayed high expression of Cyr61 correlated well with aggressive lymph node metastasis, more advanced tumor stage, histologic diffuse type, and early recurrence. Stable transfection of Cyr61 into the AGS cell line strongly enhanced its invasive activity. The overexpression of Cyr61 into AGS cells significantly increased the expression of COX-2 mRNA, protein, and enzymatic activity. Gel mobility shift assays further showed that the nuclear factor-κB (NF-κB) pathway was evidently activated in Cyr61-expressing AGS cells. Function-neutralizing antibody to αvβ3 but not αvβ5 effectively suppressed Cyr61-mediated NF-κB activation, COX-2 gene expression, and cell invasiveness. Conclusions: Cyr61 may contribute to the malignant progression of gastric cancer by promoting tumor cell motility/invasion through up-regulation of the functional COX-2 via an integrin αvβ3/NF-κB-dependent pathway.
Identification of the von Hippel-Lindau (VHL) Gene
Authors: W. Marston Linehan
Journal: JAMA (1995)

RENAL carcinoma, the most common cancer of the kidney, occurs in over 27000 individuals in the United States each year and is responsible for over 11000 deaths annually.<sup>1</sup>The incidence of renal carcinoma worldwide has been increasing at an annual rate of approximately 2%.<sup>1</sup>Although renal carcinoma has been reported in children as young as 3 years, it most commonly occurs in adults between the ages of 50 and 70 years.<sup>2</sup>Renal carcinoma affects males twice as frequently as females and accounts for approximately 3% of adult cancers. Although a number of hormonal, environmental, cellular, and genetic factors have been evaluated, little is known about the etiology of renal cancer.<sup>3</sup>There is an increased incidence of renal cancer among workers exposed to asbestos and among leather workers,<sup>4,5</sup>and a strong correlation has been found with cigarette smoking.<sup>6,7</sup>In patients with end-stage renal disease, particularly
Access to and affordability of CAR T-cell therapy in multiple myeloma: an EBMT position paper
Authors: Nico Gagelmann, Anna Sureda, Silvia Montoto, John Murray, Natacha Bolaños, Michelle Kenyon, Meral Beksac, Stefan Schönland, Patrick Hayden, Hans Scheurer, Kate Morgan, Laurent Garderet, Donal P McLornan, Annalisa Ruggeri
Journal: The Lancet Haematology (2022)
Corrigendum to “A tumor cell membrane-coated self-amplified nanosystem as a nanovaccine to boost the therapeutic effect of anti-PD-L1 antibody” [Bioact. Mater. 21 299–312]
Authors: Zhilin Li, Hao Cai, Zhiqian Li, Long Ren, Xuelei Ma, Hongyan Zhu, Qiyong Gong, Hu Zhang, Zhongwei Gu, Kui Luo
Journal: Bioactive Materials (2022)

[This corrects the article DOI: 10.1016/j.bioactmat.2022.08.028.].
Laponite intercalated biomimetic multilayer coating prevents glucocorticoids induced orthopedic implant failure
Authors: Zhe Liu, Qian Tang, Ruo-Tao Liu, Ming-Zhao Yu, Hao Peng, Chang-Qing Zhang, Zhen-Zhong Zhu, Xiao-Juan Wei
Journal: Bioactive Materials (2022)

Implant failure, which is commonly associated with failure of osseointegration and peri-implant infection, is a severe complication of orthopedic surgery. In particular, the survival rate of implants is significantly decreased in patients using long-term glucocorticoids (GCs). However, the exact molecular mechanism underlying GCs-induced implant loosening, as well as preventive strategies for these patients, is unclear. To address this problem, we performed RNA-sequencing and found that WNT16 was correlated with GCs-induced osteopenia (LogFC = -5.17, p ＜ 0.01). Inspired by the concept of "organic-inorganic" hybrid, we theorized to introduce a bioactive two-dimensional nanosheet into a layer-by-layer (LbL) self-assembly coating to construct a customized implant that targets WNT16. After screening commercially available nanosheets, laponite (LAP) was identified as a cost-effective rescuer for GCs-induced WNT16 inhibition, which was then intercalated into LbL deposition system consisting of quaternized chitosan (QCS) and hyaluronic acid (HA). The hybrid coating (QCS/HA/LAP) showed micrometer thickness and improved hydrophilicity and interface roughness. Furthermore, QCS/HA/LAP coated polyetheretherketone (PEEK) implant enhanced cell viability, adhesion, and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), and promoted osteointegration of PEEK in GCs-treated rats by targeting the WNT16/β-catenin axis. The assembled QCS has proven antibacterial properties, and the hybrid coating exerted potent detrimental effects against methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli), both in vitro and in vivo. Taken together, these results suggest that QCS/HA/LAP coating has great potential for use in implants customization, and has synergistic pro-osteogenic and antibacterial effects that help prevent implant failure in GCs-treated patients.
Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cells in acute myeloid leukemia
Authors: Diego Sánchez Martínez, Néstor Tirado, Sofia Mensurado, Alba Martínez-Moreno, Paola Romecín, Francisco Gutiérrez Agüera, Daniel V Correia, Bruno Silva-Santos, Pablo Menéndez
Journal: Journal for ImmunoTherapy of Cancer (2022)

Background Chimeric antigen receptor (CAR)-T cells have emerged as a breakthrough treatment for relapse/refractory hematological tumors, showing impressive complete remission rates. However, around 50% of the patients relapse before 1-year post-treatment. T-cell ‘fitness’ is critical to prolong CAR-T persistence and activity. Allogeneic T cells from healthy donors are less dysfunctional or exhausted than autologous patient-derived T cells; in this context, Delta One T cells (DOTs), a recently described cellular product based on MHC/HLA-independent Vδ1 + γδ T cells, represent a promising allogeneic platform. Methods Here we generated and preclinically validated, for the first time, 4-1BB-based CAR-DOTs directed against the interleukin-3α chain receptor (CD123), a target antigen widely expressed on acute myeloid leukemia (AML) blasts. Results CD123CAR-DOTs showed vigorous, superior to control DOTs, cytotoxicity against AML cell lines and primary samples both in vitro and in vivo , even on tumor rechallenge. Conclusions Our results provide the proof-of-concept for a DOT-based next-generation allogeneic CAR-T therapy for AML.
A Commentary on “The impact of regional versus general anaesthesia on postoperative neurocognitive outcomes in elderly patients undergoing hip fracture surgery: A systematic review and meta-analysis” [Int. J. Surg. 105 (2022) 106854]
Authors: Haijun Zhang, Zhipeng Zhao, Dengyan Bai, Liyi Qin, Enjia Wang
Journal: International Journal of Surgery (2022)
Association between Long-Term Air Pollution, Chronic Traffic Noise, and Resting-State Functional Connectivity in the 1000BRAINS Study
Authors: Lina Glaubitz, Johanna Stumme, Sarah Lucht, Susanne Moebus, Sara Schramm, Christiane Jockwitz, Barbara Hoffmann, Svenja Caspers
Journal: Environmental Health Perspectives (2022)

Background: Older adults show a high variability in cognitive performance that cannot be explained by aging alone. Although research has linked air pollution and noise to cognitive impairment and structural brain alterations, the potential impact of air pollution and noise on functional brain organization is unknown. Objective: This study examined the associations between long-term air pollution and traffic noise with measures of functional brain organization in older adults. We hypothesize that exposures to high air pollution and noise levels are associated with age-like changes in functional brain organization, shown by less segregated brain networks. Methods: Data from 574 participants (44.1% female, 56–85 years of age) in the German 1000BRAINS study (2011–2015) were analyzed. Exposure to particulate matter (PM10, PM2.5, and PM2.5 absorbance), accumulation mode particle number (PNAM), and nitrogen dioxide (NO2) was estimated applying land-use regression and chemistry transport models. Noise exposures were assessed as weighted 24-h (Lden) and nighttime (Lnight) means. Functional brain organization of seven established brain networks (visual, sensorimotor, dorsal and ventral attention, limbic, frontoparietal and default network) was assessed using resting-state functional brain imaging data. To assess functional brain organization, we determined the degree of segregation between networks by comparing the strength of functional connections within and between networks. We estimated associations between air pollution and noise exposure with network segregation, applying multiple linear regression models adjusted for age, sex, socioeconomic status, and lifestyle variables. Results: Overall, small associations of high exposures with lesser segregated networks were visible. For the sensorimotor networks, we observed small associations between high air pollution and noise and lower network segregation, which had a similar effect size as a 1-y increase in age [e.g., in sensorimotor network, −0.006 (95% CI: −0.021, 0.009) per 0.3 ×10−5/m increase in PM2.5 absorbance and −0.004 (95% CI: −0.006, −0.002) per 1-y age increase]. Conclusion: High exposure to air pollution and noise was associated with less segregated functional brain networks. https://doi.org/10.1289/EHP9737