tbuckley/cabot-search huggingface dataset:
Left Lower Pulmonary Lobe Transplantation
Authors: Otto Gago
Journal: JAMA (1965)

Human total lung homotransplantation requires either a source of immediate postmortem lungs, adequate storage techniques, or the sacrifice of an entire lung by a living donor. Necessitating sacrifice of smaller amounts of normal lung tissue by the donor would appear more reasonable and still be of significant benefit to the recipient. The anatomic relations of the human and canine left lower lobe make it suitable for homotransplantation, and in addition it represents 25% of the total lung function. At the same time, as an experimental technique it provides us with a better model to study homograft response of transplanted lung tissue than does total lung homotransplantation since it has a less associated mortality and requires little or no blood for transfusion at operation. Thus pulmonary alterations due to incompatible blood were avoided.<sup>1,2</sup> This work was planned to study the functional and morphological changes associated with (1) homotransplantation of the
Tc-99m Labeled HIDA Imaging in Suspected Biliary Leaks after Liver Transplantation
Authors: W SCOTT-SMITH, A T RAFTERY, E P WRAIGHT, R Y CALNE
Journal: Clinical Nuclear Medicine (1983)

Tc-99m labeled HIDA imaging has been used to investigate suspected biliary leaks following orthotopic liver transplantation. In two patients the diagnosis of bile leakage was confirmed and appropriate surgical intervention undertaken. In a third patient, despite clinical suspicion, no leakage was apparent on HIDA imaging, and unnecessary surgery was avoided. HIDA imaging is a useful, noninvasive technique for confirming biliary leakage after liver transplantation.
"Modern Clinical Syphilology."
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coated Plaquenil Tablets: Potential Risk for Children?
Authors: George E. McLaughlin
Journal: JAMA (1991)

<h3>To the Editor.</h3> —I understand that in the very near future Sanofi Winthrop Pharmaceuticals will be introducing a new coated form of Plaquenil tablet that will replace the noncoated tablet that we have used for over 25 years. I am concerned about the wisdom of this marketing decision. Plaquenil (hydroxychloroquin sulfate) is a member of the 4-amino quinoline family and differs from chloroquine by the substitution of a hydroxyl at the 2 position on one of the ethyl substituents on the tertiary amino nitrogen in the side chain. The cardiac toxicity of chloroquine is well documented, both in children and adults.<sup>1</sup>Profound cardiovascular collapse and death have been reported with as little as 1 g of chloroquine phosphate.<sup>1</sup>Absorption of both of these drugs is rapid and complete, rendering conventional methods of evacuating the gut relatively ineffective. To my knowledge, there are no reports of cardiotoxicity from accidental
Highlights of This Issue
Journal: Clinical Cancer Research (2014)

Early identification of complex disease-, gene-, and drug-drug interactions and quantitative prediction of their impacts are of great importance to the rational development and optimal use of anticancer drugs.Li and colleagues illustrated the utility of in vitro-in vivo extrapolation and physiologically based pharmacokinetic modeling approach to assess interactions of veliparib, a potential chemosensitizer, with metabolizing enzyme (CYP2D6) and transporter (OCT2) in disease settings (renal impairment).The obtained quantitative information is useful in aiding decision-making regarding whether further clinical studies are needed to assess interactions and risks, and also in guiding dose optimization in response to complex drug interaction scenarios.
Agents of Apocalypse: Epidemic Disease in the Colonial Philippines
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intestinal Infarction in Shock With Survival After Resection
Authors: Joseph S. Carey
Journal: JAMA (1967)

INTESTINAL necrosis has been found infrequently at autopsy in patients dying of shock from hemorrhage, trauma, and sepsis.<sup>1</sup>However, the entity of acute hemorrhagic necrosis of the intestine following low flow states associated with cardiovascular disease is well recognized, and its pathology has been described by many observers.<sup>2-9</sup>In four recently reported autopsy series, representing a total of 240 cases of acute nonocclusive intestinal necrosis, at least 150 patients had evidence of congestive heart failure<sup>4-7</sup>; the other patients had various types of cardiovascular disease, the most frequent being generalized atherosclerosis. In several cases, infection was the primary etiologic factor. Very few patients were in the younger age group. In no instance did this lesion result from welldocumented acute uncomplicated septic or hemorrhagic shock which was not treated with vasopressors.<sup>4-7</sup>Musa<sup>5</sup>concluded from his study that the lesion did not occur as a result of shock
Correction: Article on Low Frequency on Mutations of ING1 in Human Brain Tumors
Journal: Clinical Cancer Research (2004)

In the article on Low Frequency of Mutations of ING1 in Human Brain Tumors in the December 1, 2003, issue of Clinical Cancer Research, Dr. Tatsuya Toyama’s name was misspelled.Vieyra D, Senger DL, Toyama T, et al. Altered subcellular localization and low frequency of mutations of ING1 in human brain tumors. Clin Cancer Res 2003;9:5952–61.
In Vivo Inactivation of Tobramycin by Ticarcillin
Authors: Moses S. S. Chow
Journal: JAMA (1982)

Inactivation of tobramycin sulfate by ticarcillin disodium was observed in a patient with impaired renal function. Tobramycin elimination half-life was seven hours with concurrent ticarcillin therapy but 35 hours without ticarcillin therapy. The magnitude of change cannot be attributed to changing renal function or tobramycin accumulation. The present case demonstrates that in vivo inactivation of tobramycin by ticarcillin can substantially increase the overall tobramycin elimination rate in patients with severe renal failure; however, in patients with normal renal function such inactivation is predicted to cause little change in overall tobramycin elimination rate. (<i>JAMA</i>1982;247:658-659)
Transmission of Hepatitis B With Resultant Restriction of Surgical Practice
Authors: Lpudwig A. Lettau
Journal: JAMA (1986)

Five patients developed acute hepatitis B (HB) within four months after major operations by the same obstetric-gynecologic surgeon. Investigation documented that the surgeon was HB surface antigen and HB e antigen positive; all five patients had an HB subtype matching that of the surgeon and no other identifiable risk factors for HB viral infection. A seroprevalence study comparing exposed surgical and obstetric patients with a control group showed no significant additional subclinical HB transmission. The surgeon resumed his surgical practice but was required to obtain written informed consent from patients, to double-glove, and to employ appropriate surgical techniques to avoid self-injury. Seven months later, acute HB occurred in a patient two months after a cesarean section, resulting in exclusion of the surgeon from major operations. This is the fifth outbreak of nosocomial HB linked to an obstetric-gynecologic surgeon, and it reinforces the need for health care workers to receive preexposure prophylaxis with HB vaccine to prevent such occurrences. (<i>JAMA</i>1986;255:934-937)
Dermatology and Syphilology for Nurses Including Social Hygiene.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Textbook of Histology: Functional Significance of Cells and Intercellular Substances
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary Biosynthesis and Metabolism of Prostaglandins and Related Substances
Authors: Thomas E. Eling, Ariff I. Ally
Journal: Environmental Health Perspectives (1984)

On passage through the lung vascular bed, prostaglandins are removed from the circulation by a transport carrier and subsequently inactivated by intracellular enzymes. However, PGI2 is not inactivated by the lung in vivo. Although PGI2 is an excellent substrate for the intracellular enzymes in vitro, PGI2 is not a substrate for the carrier system. Thus, the transport carrier determines which circulating prostaglandin is inactivated by the pulmonary vascular bed. Also, the lung has a high capacity for forming prostaglandins from arachidonic acid. Considerable differences exist between species in relation to amount and specific prostaglandin formed as determined by incubation of 11C-PGH2 with pulmonary microsomes. The pulmonary biosynthesis and metabolism of these prostaglandins and related substances are discussed.
Highlights of This Issue
Journal: Clinical Cancer Research (2010)

Aberrant expression of inducible nitric oxide synthase (iNOS) in the tumor microenvironment has been linked to progression, metastasis, and poor prognosis of human cancers, including cutaneous melanoma. Here, Sikora and colleagues tested the efficacy of iNOS-directed targeted therapy for the treatment of established human melanoma xenografts in SCID/NOD mice. Oral treatment with the iNOS-selective small molecule antagonist N6-(1-Iminoethyl)-L-lysinedihydrochloride (L-nil) inhibited melanoma growth, decreased formation of intratumoral microvessels, and enhanced the efficacy of cisplatin chemotherapy. These data support the hypothesis that iNOS expression supports tumor growth in vivo and suggest targeted iNOS inhibition is a promising therapeutic approach.Although there are hundreds of drugs currently in development for cancer, a number of constraints limit the ability of researchers to effectively evaluate all of these agents in Phase I trials. In this issue of CCR Focus, guest editors Patricia LoRusso and Lesley Seymour explore some of the barriers related to Phase I clinical trials, and discuss strategies for managing and overcoming these barriers. Some of the topics addressed include different approaches to Phase I trial design, the incorporation of biomarkers into early trials, good practices for data collection and reporting, and requirements for preclinical testing prior to conducting a first-in-human trial.The CpG island methylator phenotype (CIMP) represents a subgroup of colorectal cancers characterized by frequent promoter hypermethylation. Here, Dahlin and colleagues investigated the impact of this phenotype on patient prognosis in two large patient groups. Compared to patients with CIMP-negative tumors, CIMP-low tumor patients had poorer survival, regardless of the status of microsatellite instability screening. CIMP-high tumor patients, on the other hand, had poorer survival only in the context of microsatellite stable colorectal cancer. These findings contribute to an increased understanding of molecular subtypes and prognostic factors in colorectal cancer.A large proportion of BRCA gene variants have unknown clinical significance. To investigate the effect of BRCA DNA variants on splicing efficiency, Sanz and colleagues developed a strategy combining electronic prediction and RT-PCR–based functional splicing assays of lymphocyte mRNA or hybrid minigenes in HeLa and MCF10A cells. Anomalous RNA processing was observed in 28 out of the 57 assayed variants, and variants affected splice sites and splicing enhancers and silencers. Aberrant splicing may therefore represent a relevant pathogenic mechanism in hereditary breast/ovarian cancer, and further study of these splicing defects may increase the proportion of families that benefit from genetic counselling.
Fellowships, Grants, Awards
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Fellowships, Grants, Awards Get access JNCI: Journal of the National Cancer Institute, Volume 85, Issue 17, 1 September 1993, Page 1439, https://doi.org/10.1093/jnci/85.17.1439 Published: 01 September 1993
Awards, Appointments, Announcements
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Awards, Appointments, Announcements Get access JNCI: Journal of the National Cancer Institute, Volume 87, Issue 10, 17 May 1995, Pages 717–719, https://doi.org/10.1093/jnci/87.10.717 Published: 17 May 1995
Fetal and Neonatal Hepatitis
Authors: Martel J. Dailey
Journal: JAMA (1970)

<h3>To the Editor.—</h3> In 1961 Allison and Blumberg hypothesized that individuals receiving serum proteins of a phenotype different from their own produce antibodies. Subsequent experiment has proved this hypothesis.<sup>1</sup> It is obvious that when maternal isosensitization to the Rh factor occurs, a simultaneous isosensitization to fetal serum proteins is possible. Maternal isosensitization of fetal serum proteins could occur in the absence of Rh isosensitization. The mother and fetus would be of same Rh type but possess serum proteins of different phenotype. It is now postulated that maternal antibodies resulting from maternal isosensitization to fetal serum proteins are passively transferred to fetal circulation and thereby cause fetal hepatitis. It is possible that the antibodies could also damage other fetal organs. There are well-documented studies of fetal and neonatal hepatitis.<sup>2-4</sup>Fetal and neonatal hepatitis has been presumed to be caused by transference of virus B from the maternal carrier to
Fellowships, Grants, Awards
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Fellowships, Grants, Awards Get access JNCI: Journal of the National Cancer Institute, Volume 84, Issue 19, 7 October 1992, Page 1539, https://doi.org/10.1093/jnci/84.19.1539 Published: 07 October 1992
The dissolution of gallstones
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Treatises on the Pathology and Therapy of Disorders of Metabolism and Nutrition.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serum Testosterone Levels in Healthy Young Black and White Men&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Ross, Ronald, Bernstein, Leslie, Judd, Howard, Hanisch, Rosemarie, Pike, Malcolm, Henderson, Brian
Journal: JNCI Journal of the National Cancer Institute (1986)

Serum Testosterone Levels in Healthy Young Black and White Men Ronald Ross, M.D., Ronald Ross, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Leslie Bernstein, Ph.D., Leslie Bernstein, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Howard Judd, M.D., Howard Judd, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Rosemarie Hanisch, R.N., Rosemarie Hanisch, R.N. Search for other works by this author on: Oxford Academic PubMed Google Scholar Malcolm Pike, Ph.D., Malcolm Pike, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Brian Henderson, M.D. Brian Henderson, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 76, Issue 1, January 1986, Pages 45–48, https://doi.org/10.1093/jnci/76.1.45 Published: 01 January 1986 Article history Received: 22 March 1985 Revision received: 26 July 1985 Accepted: 17 September 1985 Published: 01 January 1986