Effect of the Friendship Bench Intervention on Antiretroviral Therapy Outcomes and Mental Health Symptoms in Rural Zimbabwe
Authors: Andreas D. Haas, Cordelia Kunzekwenyika, Josphat Manzero, Stefanie Hossmann, Andreas Limacher, Janneke H. van Dijk, Ronald Manhibi, Per von Groote, Michael A. Hobbins, Ruth Verhey, Matthias Egger, Amos Kateta, Cuthbert Mutonhodza, Favourite Machiha, Ntandoyenkosi Mhlanga, Shingai Matutururu, Tatenda Gombwiro, Millicent Gweredza, Josephine Yasmin Saide, Beauty Muchakubvura, Kudzai Mhlanga, Dennis Mwakasa, Fungai Nyikadzino Zvekare, Yvonne Chiedza Maumbe, Boldwin Maposa, Sibongile Gumbo, Japhet Kamusha, Morris Tshuma, Rejoyce Runyowa, Abigail Pikayi, Fredrick Mbiba, Chiedza Elizabeth Mutungama, Waraidzo AM Mukuwapasi, Rudo Mandabva, Sven Trelle, Ethel Manda, Duncan Tatenda Majichi
Journal: JAMA Network Open (2023)

Importance Common mental disorders (CMD), which include depression and anxiety, are prevalent among people living with HIV and are associated with suboptimal antiretroviral therapy (ART) adherence. Objective To assess the effect of a lay health worker–led psychological intervention on ART adherence, virologic suppression, and mental health symptoms. Design, Setting, and Participants Open-label pragmatic cluster trial with 1:1 block randomization of 16 health facilities in rural Bikita, Zimbabwe. Recruitment occurred from October 2018 to December 2019, and participants were followed up for 12 months, ending in December 2020. Participants were adults aged 18 years and older, who spoke English or Shona, screened positive for CMD (Shona Symptoms Questionnaire [SSQ]-14 score ≥9), received first-line ART for 6 or more months, had no World Health Organization stage 4 disease, no psychosis, were not pregnant, and provided informed consent. Data were analyzed from March 2021 to February 2022. Intervention The Friendship Bench, consisting of 6 lay health worker–led weekly problem-solving therapy sessions and optional peer-led group support. Main Outcomes and Measures The primary outcome was mean adherence during 2 to 6 months of follow-up, and the secondary outcomes were mean adherence during 1 to 12 months of follow-up, change in SSQ-14 and Patient Health Questionnaire (PHQ-9) scores (3, 6, 9, and 12 months), and viral load suppression (6 and 12 months). Results A total of 516 participants were recruited (244 in Friendship Bench and 272 in enhanced standard care facilities); 438 (84.9%) were female and the mean (SD) age was 45.6 (10.9) years. Mean (SD) adherence between 2 to 6 months was 89.9% (18.4%) in the Friendship Bench group and 87.2% (20.1%) in the control group. The intervention had no statistically significant effect on adherence between 2 to 6 months (unadjusted mean difference, 1.93 percentage points; 95% CI, −1.20 to 5.06 percentage points; P = .23), between months 1 to 12 (mean difference 0.79 percentage points; 95% CI, −2.14 to 3.71 percentage points; P = .60), or viral suppression. Declines in SSQ-14 scores from baseline to 3 months (difference, −1.65; 95% CI, −3.07 to −0.24), 6 months (difference, −1.57; 95% CI, −2.98 to −0.15), and 9 months (difference, −1.63; 95% CI, −3.05 to −0.22) were greater in the Friendship Bench than the standard care group ( P &amp;amp;lt; .05). There were no differences in the decline in the SSQ-14 scores from baseline to 12 months and in declines in PHQ-9 scores from baseline to 3, 6, 9, and 12 months. Conclusions and Relevance In this randomized trial of HIV-positive participants with CMD, the Friendship Bench intervention had no effect on adherence and viral suppression, possibly due to the absence of skill-based adherence training and a ceiling effect. Trial Registration ClinicalTrials.gov Identifier: NCT03704805