POS0992-HPR THE EFFECT OF CENTRAL SENSITIZATION ON DISEASE SEVERITY LEVELS AND PRESENTEEISM-RELATED PRODUCTIVITY LOSS IN FEMALE WORKERS WITH RA
Authors: S. Farah, F. R. Spinelli, L. Quartuccio, C. Bazzani, F. Nacci, M. Fornaro, D. Iacono, C. Baldi, S. Perniola, S. Longhino, F. Salaffi
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Patients with RA experience a decline in health-related quality of life, which is associated with increased illness severity and impairment of work abilities. Central sensitization (CS) emerges as an accurate predictor and correlate of poor pain experience. <h3>Objectives</h3> The purpose of this cross-sectional, multicentric study is to investigate the mediating role of CS in unfavorable relationships with disease activity levels, CS and work productivity loss due to presenteeism in women with RA, with the goal of identifying potential new targets for preventive interventions. <h3>Methods</h3> The study used a cross-sectional design and included 101 female workers with RA classified according to 2010American College of Rheumatology (ACR)/Europenan League Against Rhumatisms (EULAR) classification criteria. All patients filled out the italian version of the RAID, an assessment and evaluation tool that measures RA patient disease activity, progress, and outcomes. The Central sensitization Inventory (CSI) was used to measure CS, and the Work Productivity and Activity Impairment questionnaire-RA (WPAI-RA) was used to evaluate patients' employment status. RA patients were grouped into categories, based on their RAID total score. Multiple regression analysis was used to find out which factors were most likely to presenteeism. <h3>Results</h3> The patients' age ranged from 25 to 65 years, with a disease duration of 5.4 (SD 6.1) years. The CSI score was ≥ 40 in 39/101 patients (38.6%). 70 patients (69.3%) worked full-time, while 31 (30.7%) worked part-time. The majority of respondents (64.5%) reported a high degree of presenteeism with an average level of 31.8%. On the other hand, absenteeism was uncommon, with just 7.3% of respondents reporting it. %. Presenteeism was associated with higher CSI score (0.049), increased disease activity (0.0007), disease duration (0.0072) and age (0.0019) (Table 1). <h3>Conclusion</h3> CS disease activity and age were the factor most significantly associated with presenteeism-related productivity loss in RA patients. our findings have implications for health policy and emphasize the significance of identifying high-risk RA patients by monitoring CS as an indicator of presenteeism and severe disease activity. <h3>References</h3> [1]Reilly MC, Zbrozek AS, Dukes EM. The validity and reproducibility of a work productivity and activity impairment instrument. Pharmacoeconomics 1993;<b>4</b>:353–365. [2]Salaffi F, Di Carlo M, Vojinovic J, Tincani A, Sulli A, Soldano S, Andreoli L, Dall'Ara F, Ionescu R, Simić Pašalić K, Balčune I, Ferraz-Amaro I, Tlustochowicz M, Butrimienė I, Punceviciene E, Toroptsova N, Grazio S, Morović-Vergles J, Masaryk P, Otsa K, Bernardes M, Boyadzhieva V, Cutolo M. Validity of the rheumatoid arthritis impact of disease (RAID) score and definition of cut-off points for disease activity states in a population-based European cohort of patients with rheumatoid arthritis. Joint Bone Spine. 2018 May;85(3):317-322. [3]Sakai R, Tanaka E, Inoue E, Sato M, Tanaka M, Ikari K, Yamanaka H, Harigai M. Association between patient-reported outcomes and impairments in work and activity in patients with rheumatoid arthritis in clinical remission: a retrospective analysis using the IORRA database. Mod Rheumatol. 2022 Sep 12:roac105. doi: 10.1093/mr/roac105. Epub ahead of print. PMID: 36094815. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.