tbuckley/cabot-search huggingface dataset:
Oral Contraceptives and Breast Histology
Authors: Joseph Kovi
Journal: JAMA (1973)

<h3>To the Editor.—</h3> It is estimated that approximately 7 million American women took oral contraceptive hormones in 1967.<sup>1</sup>Although the shortterm effect of antiovulants has been studied, little information is available concerning the long-term effect of these drugs on mammary gland histology. In women taking hormones for a few months to a few years, the most consistent change in the normal mammary tissue was lobular hyperplasia with true acinus formation.<sup>2</sup>An example is offered. <h3>Report of a Case.—</h3> A 34-year-old black woman was hospitalized for a lump in the left breast in July 1972. She was gravida 4, para 4, AB O, and had been taking norethindrome with mestranol (Ortho-Novum [Searle]) for the past eight years. A biopsy taken from the breast disclosed an invasive ductal carcinoma in the upper outer quadrant. A left radical mastectomy was performed. The surgical specimen revealed severe sclerosis of lobules in all
More on Dietary Sodium and Blood Pressure
Authors: William B. Applegate
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Several statements in the letter by Dr Logan and colleagues<sup>1</sup>on dietary sodium and blood pressure (BP) require clarification and correction. First, the authors assert "studies including Intersalt (particularly when data from the 4 primitive societies have been excluded) have found, however, no consistent relationship."<sup>1</sup>In Intersalt analyses on individuals, results were consistent for 10 074 persons from all 52 samples and for 9343 persons from 48 samples (excluding 4 low-sodium samples); the multivariate controlled coefficients for the sodium-systolic BP relationship were—3.1 mm Hg (<i>P</i>&lt;.001) and -3.2 mm Hg (<i>P</i>&lt;.001), respectively for a 24-hour urinary sodium level 100 mmol/d lower (or -6.0 and -6.2 mm Hg without adjustment for body mass index).<sup>2</sup>Results also were similar for nonhypertensives,<sup>2</sup>indicating that "salt sensitivity" is prevalent throughout the population and is not confined mainly to hypertensives. In multivariate cross-population analyses (n=52 and n=48),
Primary Drug Resistance In Tuberculosis
Authors: Reuben Tizes
Journal: JAMA (1970)

<h3>To the Editor:—</h3> In a recent editorial (<b>212</b>:2113,1970) on "Primary Drug Resistance in Tuberculosis" an opinion was expressed that In the United States, Canada, and several countries in Europe, where large surveys have been instituted and compared for several years with the use of similar bacteriological and clinical criteria, the problem of primary drug resistance is relatively small. Furthermore, it is stated in the above editorial that "there appears to be no evidence that primary resistance to streptomycin, isoniazid, and aminosalicylic acid is increasing." We are, however, taking strong exceptions to statements expressed in the editorial because of the following: Many of the surveys referred to by the author have been conducted in the late 50s and very early 60s, a short period following the introduction of isoniazid. In addition, a great many studies have been limited to select population groups. One can not generalize and make strong statements
Zaire: Nonsexual Household Transmission of AIDS
Authors: Kenneth J. Rothman
Journal: JAMA (1986)

<h3>To the Editor.—</h3> Mann et al<sup>1</sup>claim that their study in Zaire "provides evidence against horizontal HTLV-III/LAV [human T-cell lymphotropic virus type III/lymphadenopathy-associated virus] transmission among household members." Actually, their data indicate the opposite. They found nine of 186 household contacts (excluding spouses) of patients with the acquired immunodeficiency syndrome (AIDS) to be seropositive, compared with only two of 128 household contacts of controls who were seronegative and matched to the AIDS cases by age and sex. The numbers may be small, but they are not comforting. The authors report a prevalence ratio estimate of 3.1, with a 95% confidence interval of 0.7 to 13.3. The authors state that "seroprevalence did not differ significantly between case-and control-household contacts," and claim that the data provide support for the null hypothesis. The confidence interval, however, indicates that the data are compatible with a wide range of values for the prevalence ratio.
Interpretation of the ECG: Before or After Mounting? Admissibility as Evidence
Authors: David Littman
Journal: JAMA (1971)

<h3>To the Editor.—</h3> The question as it appeared originally inThe Journalwas: "Is an electrocardiogram<i>admissible in evidence in a court of law</i>if it is clipped and mounted before the cardiologist reads the tracing...?" (<b>213</b>:2088, 1970) The concluding portion of the answer was: The mounted excerpt of the ECG may or may not be admissible in evidence, depending upon the issues in the case and the effect of local rules of evidence, but in any event it would seem to me that the weight which it would carry in court could certainly be diminished by a cross-examination which would expose the facts alluded to above. Unlike an x-ray film, a segment of which may or may not be representative of the whole, a single, properly selected beat can be characteristic or typical of the whole lead. Granted that a nonrepresentative single beat could be selected by inadvertence
Penicillin and Gentamicin Therapy For Enterococcal Infections
Authors: Allan J. Weinstein
Journal: JAMA (1973)

None of the currently available antibiotic regimens is completely effective for the therapy of severe enterococcal infections. Recent studies have shown that a combination of penicillin plus gentamicin produces enhanced killing against virtually all strains of enterococci in vitro. We report four cases of enterococcal endocarditis and two cases of enterococcal meningitis that were successfully treated with penicillin and gentamicin, thus confirming the in vivo effectiveness of this combination of antibiotics against enterococci.
Plasma Demeclocycline Levels and Nephrotoxicity
Authors: Paul D. Miller
Journal: JAMA (1980)

In five hyponatremic, cirrhotic patients, demeclocycline hydrochloride was used to inhibit the hydroosmotic effect of vasopressin. In four, renal impairment developed during the 7 to 20 days of demeclocycline hydrochloride (900 to 1,200 mg/day) administration. In these four patients, creatinine clearance fell (72 to 20 mL/min,<i>P</i>&lt;.01) as BUN (12 to 47 mg/dL,<i>P</i>&lt;.02) and serum creatinine (0.9 to 4.2 mg/dL,<i>P</i>&lt;.01) levels rose. The azotemic effect of the drug could not be accounted for consistently by volume depletion secondary to its natriuretic effect. However, a close correlation between plasma demeclocycline levels and its azotemic effect was observed. We conclude that a nephrotoxic effect of demeclocycline severely limits its usefulness in treating hyponatremia in the cirrhotic patient. (<i>JAMA</i>243:2513-2515, 1980)
Counsels and Ideals. From the Writings of William Osler.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Prognosis in Chronic Bronchitis
Authors: Geoffrey L. Brinkman
Journal: JAMA (1966)

In 1958, 1,317 men working in the Detroit area were selected for study on the basis of two criteria: they were aged 40 to 65 years and working full-time. They were classified into four working groups: (1) no industrial exposure, (2) general industrial exposure, (3) 20 years of silica-dust exposure, and (4) 20 years of silica-dust exposure with roentgenogram evidence of silicosis. They were classified further as to whether they had chronic bronchitis, which was defined as a daily cough for six months, productive of at least a teaspoon of sputum a day. In 1964, the same group of men were reexamined using the same questionnaire as was used in 1958. A spirogram and chest roentgenogram were obtained as well. Altogether, 1,056 men were followed, which includes 123 men who died during this time. In this sample of the Detroit male population, the presence of chronic bronchitis did not have any significant adverse effect on health, working ability, or ventilation of these men over a six-year period.
Reversible cutaneous lymphoma occurring during methotrexate therapy
Authors: R. VIRABEN, P. BROUSSE, L. LAMANT
Journal: British Journal of Dermatology (1996)

Summary A B-cell lymphoma, restricted to the skin, developed in a 58-year-old man receiving methotrexate for non-rheumatoid peripheral arthritis, with the simultaneous occurrence of a cytolytic hepatitis and carcinoma of the lung. Two weeks after methotrexate was stopped, both the skin tumour and the hepatitis disappeared spontaneously, with no recurrence during a 12-month follow-up period. Immunoglobulin gene rearrangement was shown by polymerase chain reaction (PCR) but in situ hybridization failed to reveal neoplastic cells positive for Epstein-Barr virus (EBV).
Methadone Deaths in Children
Authors: John E. Smialek
Journal: JAMA (1977)

SINCE the inception of methadone maintenance clinics in the late 1960s, accidental poisoning of children with methadone has been reported by several authors. In spite of legislation intended specifically to prevent accidental poisoning in children,<sup>1-3</sup>a lack of uniformity in packaging of methadone supplies and in the education of methadone recipients constitutes a continuing safety hazard for children. This is apparent from the occurrence of 120 cases of methadone poisoning in children treated at Children's Hospital of Michigan since the establishment of methadone maintenance clinics in metropolitan Detroit. Furthermore, in the past three years, four deaths in children ranging in age from 5 weeks to 3 years have been examined at the Office of the Medical Examiner of Wayne County. These cases are described individually, with particular emphasis on the mechanism by which the children ingested the drug. In all four cases, methadone was quantitated in the blood of
A Text-Book of Psychology for Nurses.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Functional chiral asymmetry in descending thoracic aorta.
Authors: L J Frazin, G Lanza, M Vonesh, F Khasho, C Spitzzeri, S McGee, D Mehlman, K B Chandran, J Talano, D McPherson
Journal: Circulation (1990)

To determine whether rotational blood flow or chiral asymmetry exists in the human descending thoracic aorta, we established the ability of color Doppler ultrasound to detect rotational flow in a tornado tube model of a vortex descending fluid column. In a model of the human aortic arch with a pulse duplicator, color Doppler was then used to demonstrate that rotational flow occurs first in the transverse arch and then in the proximal descending thoracic aorta. With the use of color Doppler esophageal echocardiography, 53 patients (age range, 25-78 years; mean age, 56.4 years) were prospectively examined for rotational flow in the descending thoracic aorta. At 10 cm superior to retro-left ventricular position, 22 of 38 patients (58%) revealed rotational flow with obvious diastolic counterclockwise rotation but less obvious systolic clockwise rotation. At 5 cm superior to retro-left ventricular position, 29 of 46 patients (63%) revealed rotational flow with a tendency toward systolic clockwise and diastolic counterclockwise rotation. At the retro-left ventricular position, 47 of 53 patients (89%) revealed rotational flow, usually of a clockwise direction, occurring in systole. Our data suggest that aortic flow is not purely pulsatile and axial but has a rotational component. Rotational flow begins in the aortic arch and is carried through to the descending thoracic aorta, where flow is chirally asymmetric with systolic clockwise and diastolic counterclockwise components. These data demonstrate an aortic rotational flow component that may have physiological implications for organ perfusion.
Seventh Congress of the International BioIron Society (IBIS) Biennial World Meeting (BioIron 2017) May 7 – 11, 2017
Authors: Augusta Savino, Arianna Savi, Daniela Gallo, Valentina Gaidano, Patrizia Scaravaglio, Mauro Mezzabotta, Giuseppe Saglio, Daniela Cilloni, De Gobbi Marco
Journal: American Journal of Hematology (2017)
Highlights of This Issue
Journal: Clinical Cancer Research (2013)

Most patients on androgen deprivation therapy eventually develop castration-resistant prostate cancer (CRPC).Here, the recently approved androgen antagonist enzalutamide was evaluated in combination with immunotherapy in a mouse transgenic prostate cancer model.This article described a novel immunogenic modulation property of enzalutamide, where treatment of enzalutamide improves tumor cells' sensitivity to T-cell mediated attack.In vivo, enzalutamide reduced genitourinary tissue weight, enlarged thymus, and increased levels of T-cell excision circles.The combination of enzalutamide and immunotherapy significantly improved overall survival of transgenic mice with advanced disease.These data support the combination of enzalutamide and immunotherapy as a promising treatment for CRPC.
Physics in Medical Radiology.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Albinism in Nigeria1
Authors: A.N. OKORO
Journal: British Journal of Dermatology (2006)

Journal Article Albinism in Nigeria: A CLINICAL AND SOCIAL STUDY Get access A.N. OKORO A.N. OKORO Department of Dermatology, University of Nigeria Teaching Hospital, Enugu, Nigeria Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 92, Issue 5, 1 May 1975, Pages 485–492, https://doi.org/10.1111/j.1365-2133.1975.tb03116.x Published: 01 May 1975 Article history Accepted: 13 September 1974 Published: 01 May 1975
Intravenously Given Conjugated Estrogens
Authors: Leo R. Zacharski
Journal: JAMA (1973)

A double-blind crossover study comparing intravenously administered conjugated estrogens (CE) and a placebo failed to demonstrate a significant effect on capillary resistance to a standard negative pressure stress or the bleeding time in normal subjects. The occurrence of deep calf vein thrombosis within 24 hours of CE administration in a healthy 46-year-old male volunteer raised the possibility of an etiologic relationship. The study did not support the widely held contention that CE promote hemostasis in normal individuals by enhancing capillary stability.
Awards, Appointments, Announcements
Journal: JNCI Journal of the National Cancer Institute (1994)

Awards, Appointments, Announcements Get access JNCI: Journal of the National Cancer Institute, Volume 86, Issue 21, 2 November 1994, Pages 1582–1583, https://doi.org/10.1093/jnci/86.21.1582 Published: 02 November 1994
Vinca Alkaloid Skin Toxicity: Antidote and Drug Disposition Studies in the Mouse&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Robert T. Dorr, David S. Alberts
Journal: JNCI Journal of the National Cancer Institute (1985)

A murine (BALB/c) skin toxicity model was used to evaluate various possible antagonists to vinca alkaloid-induced skin ulceration. Reproducible dose-response relationships were developed for vinblastine (VBL) and vindesine (VDS). With vincristine (VCR) only about 70% of mice developed dose-dependent ulceration. On an equal weight basis, VCR proved to be significantly more toxic than either VBL or VDS (P<.05 by Student's t-test). Effective local intradermal antidotes to VBL, VDS, and VCR included hyaluronidase, normal saline, and calcium leucovorin (P<.05 by the Student's Newman-Keuls multiple range test). Mild, topical skin heating significantly reduced VCR ulceration. In contrast, diphenhydramine and sodium bicarbonate were ineffective as local antidotes. Topical skin cooling, however, significantly increased vinca-induced skin ulcers for VBL, VDS, and VCR (P<.05). Hydrocortisone, vitamin A topical cream, and isoproterenol increased skin toxicity. [3H]VBL was given intradermally to follow the drug's pharmacokinetic disposition from the skin and adherent panniculus carnosus muscle. [3H]VBL exhibited two phases of elimination: a rapid early phase [half-life (t½) of ≈30 min] and a prolonged terminal phase (t½ of ≈17 hr). The application of heat increased the distributive, early phase by 0.5–2.5 hours and did not enhance the terminal elimination of the drug from skin. Intradermal hyaluronidase significantly reduced the area under the ulceration multiplied by the time curve to one-seventh the control value, the peak [3H]VBL skin concentration to one-half the control value and the terminal [3H]VBL t½ in skin to one-third the control level (P<.05 by Student's t-test). These results show hyaluronidase to be an effective antidote for vinca-induced skin ulceration. Local glucocorticosteroids and topical cooling are definitely contraindicated in the management of inadvertent vinca alkaloid extravasations.
Small-Vessel Cutaneous Vasculitis
Authors: George E. Ehrlich
Journal: JAMA (1982)

The major aim of descriptive clinical studies should be to define identifiable subgroups and syndromes for their prognostic and therapeutic importance. Prognosis is coming into its own as a discipline<sup>1</sup>and remains the hidden question behind the patient's desire to know the diagnosis. Clinicians must incorporate it into their explanation or run the risk of being like the physician in Matthew Arnold's quatrain: Nor bring to watch me cease to live some doctor, full of phrase and fame to shake his sapient head and give the ill he cannot cure a name. To deliver a diagnosis without elaborating on what it means for the future is to send the patient to other sources for the information, many of which he cannot use properly. The diagnosis of vasculitis is one such potential trouble spot. A whole spectrum of conditions is included under that simple label, among which can be found
A Piece of My Mind
Authors: Ronald F. Galloway
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal