tbuckley/cabot-search huggingface dataset:
Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA
Authors: Jerome R. Lo Ten Foe, Martin A. Rooimans, Lucine Bosnoyan-Collins, Noa Alon, Mario Wijker, Linda Parker, Jeff Lightfoot, Madeleine Carreau, David F. Callen, Anna Savoia, Ngan C. Cheng, Carola G.M. van Berkel, Mark H.P. Strunk, Johan J.P. Gille, Gerard Pals, Frank A.E. Kruyt, Jan C. Pronk, Fré Arwert, Manuel Buchwald, Hans Joenje
Journal: Nature Genetics (1996)
An Approach to Social Medicine.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endoscopy International Open – recently published
Journal: Endoscopy (2017)

Comment on: Endoscopic pancreatic necrosectomy: why scuff when you can flush the muck – make it an easy row to hoeEndosc Int Open 2017; 05(09): E847-E853DOI: 10.1055/s-0043-112854 Comment on: Safety and efficacy of coaxial lumen-apposing metal stents in the management of refractory gastrointestinal luminal strictures: a multicenter studyEndosc Int Open 2017; 05(09): E861-E867DOI: 10.1055/s-0043-114665 Comment on: Double endoscopic bypass for gastric outlet obstruction and biliary obstructionEndosc Int Open 2017; 05(09): E893-E899DOI: 10.1055/s-0043-115386
Diagnosis of Intra-abdominal Abscess
Authors: Alan G. Giberson
Journal: JAMA (1982)

<h3>To the Editor.—</h3> I read the article by Joseph T. Ferrucci, Jr, MD, and Eric vanSonnenberg, MD (1981;246:2728), regarding radiological diagnosis and treatment of intra-abdominal abscesses. They reported 90% to 95% rates of true-abnormal and truenormal accuracy. I have treated a patient with hypertension and renal failure who had a weight loss of 45 kg and abdominal pain. A series of six upper gastrointestinal studies, three barium enema examinations, three computed tomographic scans, laparoscopy, and abdominal aortography all failed to yield a diagnosis. A third surgical opinion suggested laparotomy, and a 2-L abdominal abscess at the site of an intestinal perforation was found. The patient eventually died. The editorial comment of Charles B. Clayman, MD (1981;246:2727), reiterating that ultrasophisticated diagnostic methods should not unduly influence a clinical decision is affirmed. Although helpful and occasionally dramatic findings can be achieved with new techniques, clinical evaluation and determination are still necessary.
Clinical SPRINT Imaging
Authors: JAMES M. MOUNTZ, W LESLIE ROGERS, MARK W. WILSON, NEIL H. CLINTHORNE, MILTON D. GROSS, NANCY N. SPEED, JOSEPH A. SCHWARTZ
Journal: Clinical Nuclear Medicine (1991)

We have performed initial clinical studies using the high resolution single photon ring tomograph (SPRINT) and Tc-99m HMPAO. To determine what additional anatomic detail can be depicted using this high resolution, dedicated head, multidetector SPECT device compared to conventional SPECT, six patients with stroke and one normal volunteer were imaged after the injection of 20 mCi Tc-99m HMPAO on a conventional rotating Anger gamma camera (GE-400AC), followed immediately by imaging on SPRINT. Imaging acquisition on the GE-400AC gamma camera was performed using 360 rotation, 64 stops, at 30 seclstop, yielding an average of 985,714 counts for a 10.0 mm thick slice. GE-400AC images were of good quality, having in-plane full width half maximum (FWHM) resolution of approximately 15mm. SPRINT acquisition of image data was performed using both the high resolution and high sensitivity apertures, with data collection over 15 or 20 minutes of imaging time accumulating approximately 500,000 counts and 1,000,000 counts, respectively, from patients in a 10.0 mm thick slice, achieving an in-plane FWHM resolution of approximately 8 mm and 10 mm for the two apertures, respectively. Both image resolution and contrast for visualization of gray, white, and cerebral spinal fluid filled brain structures were improved using SPRINT compared with theGE-4OOAC. We conclude that SPRINT is well suited for brain imaging with Tc-99m HMPAO and is of particular value for applications demanding high resolution.
Highlights of This Issue
Journal: Clinical Cancer Research (2017)

Low-dose DNA demethylating agent decitabine has been used and has shown clinical effectiveness for the treatment of solid tumors, while the previous researches mainly focused on its effects on cancer cells. Li and colleagues examined whether low-dose decitabine treatment directly influences T-cell activation and cytolysis-mediated antitumor responses. Based on in vitro, in vivo and clinical trial studies, low-dose decitabine therapy could enhance the activation, proliferation and cytolytic activity of human IFN-γ+ T cells, which was correlated with improved therapeutic responses and survival of cancer patients, thus highlighting the important role of antitumor immune regulation during decitabine-based therapy.Current treatment strategies including single agent endocrine agents or combinations with CDK4/6 inhibitors increased capabilities of effective treatment for patients with hormone-receptor positive (HR+) metastatic breast cancer. Liquid biopsies are emerging as an important area of biomarker development for assessment and monitoring of disease heterogeneity. Paollillo and colleagues performed a prospective study to evaluate estrogen-receptor expression and ESR1 mutations in patients with HR+ disease with measurable CTC by standard method. They demonstrated the feasibility of single cells molecular analysis and discovered both phenotypic and genotypic heterogeneity a phenomenon that can only be described by using CTC.ER+/FGFR1-amplified breast cancer cells and tumors retain proliferation and ERα genomic activity despite estrogen deprivation therapy. Formisano and colleagues show that combined inhibition of ERα and FGFR1 induced regression of ER+/FGFR1-amplified breast cancer cells and patient-derived xenografts, supporting further development of combinations of ER and FGFR antagonists for the treatment of patients with this subtype of breast cancer.Abundant nontumor cells are enriched in glioma tissues, which might dilute the purity of glioma cells and play important roles in glioma biology. To characterize the biological and clinical features of glioma purity, Zhang and colleagues performed a comprehensive analysis on more than 2,000 glioma tissues. Glioma purity conferred critical implications in multiple dimensions. Low purity cases were characterized by malignant phenotypes, poor prognosis, distinct genomic alterations and infiltration of specific immune cells. This study highlights the importance of glioma purity and the infiltrated nontumor cells, which may provide insights into precise classification, clinical prediction, and effective therapeutic strategy.
α-Adrenoceptor-Mediated Coronary Artery Spasm
Authors: Donald L. Levene
Journal: JAMA (1976)

Selective coronary arteriography performed on a 41-year-old woman with angina pectoris demonstrated proximal stenosis of the right and left main coronary arteries that was unaffected by nitrate therapy. To exclude coronary artery spasm, the study was repeated, and a striking increase in the narrowing of the right coronary artery was observed. This 90% stenosis was virtually abolished by pretreatment with intravenously given phentolamine hydrochloride. Prolonged α-adrenoceptor blockade with phenoxybenzamine hydrochloride improved the patient's exercise tolerance and postexercise electrocardiographic abnormalities when compared to therapy in matched controls given placebo. These observations suggest that α-adrenoceptor-mediated coronary artery spasm may mimic organic lesions at coronary arteriography and may be a factor in the pathogenesis of angina pectoris in some patients. (<i>JAMA</i>236:1018-1022, 1976)
Donald Fredrickson, MD: 'high priest'
Authors: John Elliott
Journal: JAMA (1980)

Known in Washington political circles as the "high priest" of biomedical research, Donald S. Fredrickson, MD—scientist, politician, and bureaucrat—has had what can only be described as a highly successful career spanning almost 30 years. Director of the National Institutes of Health (NIH) since 1974, Fredrickson has proved himself adept at treading the political terrain. He is also a survivor. Nominated by Gerald Ford (the NIH directorship is a presidential appointment requiring congressional ratification), he has served both Democrat and Republican administrations. He is the only top official of the Department of Health and Human Services (DHHS—formerly the Department of Health, Education, and Welfare) to withstand the wholesale firings carried out by former Secretary Califano in 1976. Now Califano is gone and Fredrickson serves his fourth DHHS Secretary, Patricia Harris. Politics aside, Fredrickson has, so far, been adroit as well in handling the tough challenges that the 36-year-old NIH has faced
Evaluation of Mirex, Photomirex and Chlordecone in the Terrestrial Aquatic Laboratory Model Ecosystem
Authors: B. Magnus Francis, Robert L. Metcalf
Journal: Environmental Health Perspectives (1984)

The insecticides mirex and chlordecone and the mirex photodegradation product, photomirex, were evaluated in a terrestrial aquatic laboratory model ecosystem. Although chlordecone was to some extent degraded during the 33 days, neither mirex nor photomirex produced identifiable levels of decomposition products in the water or in any of the organisms of the model ecosystem. All three compounds accumulated significantly in the organisms of the model ecosystem, with chlordecone the least bioaccumulative and photomirex the most bioaccumulative.
The Trauma Score as a Triage Tool
Authors: Charles J. McCabe
Journal: JAMA (1987)

<h3>To the Editor.—</h3> In the article by Morris et al,<sup>1</sup>the authors describe the Injury Severity Score and the methods of calculating it. They divided the body into seven regions (head and face, neck, chest, spine, abdomen and pelvic contents, extremities and pelvic girdle, and integument). However, in the 1985 revision of the abbreviated injury scale, published by the American Association for Automotive Medicine, the body is divided into six areas (head or neck, face, chest, abdominal or pelvic contents, extremities or pelvic girdle, and external). Morris et al have increased the number of body areas scored by adding<i>spine</i>. Has the 1985 edition of the abbreviated injury scale been altered by them or by the American Association for Automotive Medicine?
Suppression of Tumorigenicity in Somatic Cell Hybrids. II. Human Chromosomes Implicated as Suppressors of Tumorigenicity in Hybrids With Chinese Hamster Ovary Cells&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Harold P. Klinger, M.D., Ph.D., Thomas B. Shows, Ph.D.
Journal: JNCI Journal of the National Cancer Institute (1983)

Nontumorigenic diploid human cells were fused with tumorigenic Chinese hamster ovary cells (CHO), and the hybrids were tested for tumorigenicity to determine if specific human chromosomes are associated with suppression of tumorigenicity in cell hybrids. Chromosome complements of cells of 62 nontumorigenic and 45 tumorigenic hybrids (divided into those of low, medium, and high tumorigenicity) as well as 44 tumors derived from the tumorigenic hybrids were determined by both analysis of banded chromosomes and assays of gene markers. Although no single human chromosome was consistently associated with the suppressed phenotype, chromosome 2 was never found in tumor cells, and chromosomes 9, 10, 11, and 17 were found at very low incidences in tumor cells, which suggested that they carry tumorigenicity suppressor information. Since not all suppressed hybrids contained these chromosomes, it is likely that they suppressed tumorigenicity only in combination with each other or other chromosomes. Nine chromosomes in 12 pairwise combinations of nonhomologous chromosomes were not found in tumor cells and were found at an incidence of 5% or less in hybrids of both medium and high tumorigenicity. Other experiments implicated 11 of these combinations involving only 8 chromosomes (chromosomes 4, 7, 8, 9, 10, 11, 13, and 17) as those primarily involved in suppression. Whether chromosome 2 requires another chromosome to effect suppression could not be determined. Further evaluations of the implicated suppressors, including selection of tumorigenic segregants from a panel of suppressed hybrids, again implicated the same chromosomes and their combinations in suppression. Oncogenes have been mapped to many of these chromosomes, and they are frequently involved in tumor-type-specific numerical or structural abnormalities in human neoplasias. The combined evidence suggests that specific human chromosomes of a normal cell carry genes that can regulate several cell phenotypes necessary for the expression of tumorigenicity.
Relationship Between Dietary Fat Composition and Colorectal Neoplasia
Authors: Berry, Elliot M., Zimmerman, Joseph, Ligumsky, Moshe
Journal: JNCI Journal of the National Cancer Institute (1987)

Journal Article Relationship Between Dietary Fat Composition and Colorectal Neoplasia Get access Elliot M. Berry, M.D., M.R.C.P., Elliot M. Berry, M.D., M.R.C.P. 1Department of Medicine B Hadassah University Hospital, P.O. 12000 Jerusalem, Israel Search for other works by this author on: Oxford Academic PubMed Google Scholar Joseph Zimmerman, M.D., Joseph Zimmerman, M.D. 2Department of Gastroenterology Hadassah University Hospital, P.O. 12000 Jerusalem, Israel Search for other works by this author on: Oxford Academic PubMed Google Scholar Moshe Ligumsky, M.D. Moshe Ligumsky, M.D. 2Department of Gastroenterology Hadassah University Hospital, P.O. 12000 Jerusalem, Israel Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 78, Issue 2, February 1987, Pages 395–396, https://doi.org/10.1093/jnci/78.2.395-a Published: 01 February 1987
Pathologic and Biochemical Effects of Azaserine in Inbred Wistar/Lewis Rats and Noninbred CD®-1 Mice&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn3"&gt;3&lt;/xref&gt;
Authors: B. D. Roebuck, Herman S. Lilja, Thomas J. Curphey, Daniel S. Longnecker
Journal: JNCI Journal of the National Cancer Institute (1980)

Inbred W/LEW rats and noninbred CD®-1 mice were compared for responsiveness to induction of pancreatic adenocarcinomas by azaserine. At 1 year following the first of 15 weekly ip injections of 10 mg azaserine/kg body weight, the rats had a pancreatic adenoma incidence of 71% (12/17) and a pancreatic adenocarcinoma incidence of 35% (6/17), with 1 invasive adenocarcinoma. The mice showed none of these advanced lesions, although numerous pancreatic atypical acinar cell nodules (AACN) were present. An examination of the number and size of the AACN showed the rats to have more and larger AACN than did the mice. The concentration of [14C]azaserine and/or its metabolites was greater in rat pancreas than in mouse pancreas. Alkaline sucrose gradients were used to compare azaserine-induced pancreatic and liver DNA damage in W/LEW and F344 rats, the CD®-1 mouse, the Syrian golden hamster, and the strain 13 guinea pig. DNA damage was detected 1 hour following azaserine administration in both pancreata and livers of all animals tested and persisted for at least 1 week in the pancreata of all animals except the CD®-1 mouse; however, neither the degree nor persistence of DNA damage accurately reflected the differing responsiveness of these species to induction of pancreatic AACN or neoplasms by azaserine.
Homosexuality and Medicine
Authors: Charles W. Socarides
Journal: JAMA (1970)

Homosexuality is a medical disorder which has reached epidemiologic proportions; its frequency of incidence surpasses that of the recognized major illnesses in the nation. Homosexuality may be classified in two categories: obligatory (true) homosexuality and episodic homosexual behavior. It is essential to differentiate carefully between these types in order to determine the significance of the disorder, its treatment, and its prognosis. This condition is not innate or inborn but is an acquired, learned maladaptation arising from faulty gender identity in the earliest stages of life. Only massive childhood fears can damage and disrupt the standard male-female pattern and ultimately lead to the later development of obligatory homosexuality.
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Soccerball-Induced Eye Injuries
Authors: Miles J. Burke
Journal: JAMA (1983)

We report a series of 24 contusion eye injuries resulting from soccerball impact. Hyphema (50%), vitreous hemorrhage (29%), corneal abrasion (21%), angle recession (8%), and retinal tear (4%) were experienced. When compared with a combined hyphema series and with hockey and racquet sports, our group had fewer serious injuries and no permanent visual acuity loss resulted. Although the incidence of eye injuries is low and the use of eye protectors may be inconvenient, we strongly recommend protective eyewear be worn in competitive sports involving large and small projectiles. (<i>JAMA</i>1983;249:2682-2685)
Lonidamine, a Selective Inhibitor of Aerobic Glycolysis of Murine Tumor Cells&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Aristide Floridi, Marco Giorgio Paggi, Maria Luisa Marcante, Bruno Silvestrini, Antonio Caputo, Cesare de Martino
Journal: JNCI Journal of the National Cancer Institute (1981)

The action of Lonidamine [1-(2,4-chlorobenzyl)-1H-indazol-3-carboxylic acid] on respiration and aerobic lactate production of several murine tumor cells and normal differentiated murine cells was investigated. Lonidamine reduced the oxygen consumption in both normal and neoplastic cells. In contrast, it increased the aerobic glycolysis of normal cells but inhibited that of tumor cells. This selective action might be ascribed to the inhibition of mitochondrially bound hexokinase, which is usually absent in normal differentiated cells.
Lectin-Dependent Cell-Mediated Cytotoxicity: Assessment of Cytotoxic Reactivity Following Challenge With Syngeneic Tumors&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: D. C. Laux, B. M. Parker, S. O. DiSciullo, M. A. Petrarca, C. G. McAllister
Journal: JNCI Journal of the National Cancer Institute (1984)

Spleen cells from syngeneic tumor-bearing mice were examined for direct cell-mediated cytotoxicity (DCMC) and lectin-dependent cell-mediated cytotoxicity (LDCC). In the DCMC assay specific cytotoxicity against the homologous tumor cell was assessed. In the LDCC assay cytotoxicity was nonspecifically assessed against EL-4 cells in the presence of concanavalin A or phytohemaglutinin. Most tumor lines tested (19/22) produced no cytotoxic reactivity in either the DCMC or LDCC assays. In the case of the remaining tumor lines (EL-4, BW5147-3, and P815 Y-3), significant LDCC, but not DCMC, was detected, which indicated that although cytotoxic effector cells had been activated, the reactivity was not directed toward the homologous tumor cell or could not be expressed in the DCMC assay. The EL-4 and BW5147-3 cell lines proved to be sporadic in terms of their ability to induce LDCC, whereas the P815 Y-3 cell line produced consistent LDCC. Reactivity induced by P815 Y-3 cells appeared to be due to the constitutive production and release of a soluble component which could activate cytotoxic T-cells in vivo.
Doctors convicted of manslaughter.
Authors: R. Hardern, R. Pope
Journal: BMJ (1992)

future.The development of a coherent strategy across all sectors following a health lead has been shown to be possible in Wales.4NHS regions in the United Kingdom may have the option of looking towards Brussels rather than Whitehall for health policy in the longer term.The mere suggestion of this may be enough to get Whitehall departments collaborating more effectively to fill "the hole at the centre."
Nonoperative Ligation Treatment of Internal Hemorrhoids
Authors: Norman W. Frink
Journal: JAMA (1968)

A hemorrhoidectomy is extremely unpleasant for the patient. He has a great deal of pain afterward, and he can vividly recall his first postoperative bowel movements for a very long time! After several well-remembered days in the hospital, he is still usually unable to return to work for one to three weeks. In addition to the pain and suffering, the operation can cost a lot of money. If the surgeon's and the anesthesiologist's fees, the operating room and hospital charges, and the patient's lost earnings are totaled, the expense is often considerable. Hemorrhoids are essentially benign. They rarely, if ever, threaten life. After all, hemorrhoids are only varicosities occurring in veins normally present in the rectum. Asymptomatic hemorrhoids probably need not be treated at all. Hemorrhoids, however, can be most unpleasant and disagreeable. They can bleed; they can protrude. Often they are quite uncomfortable. Sometimes they hurt. As a rule,