tbuckley/cabot-search huggingface dataset:
Detection of Hepatic Neoplasm
Authors: Freddie E. Wilson
Journal: JAMA (1969)

In 69 patients, hepatic scans with gold Au 198 and determinations of serum alkaline phosphatase (SAP) levels were 78% accurate (in 14 of 18 patients) and 80% accurate (in 12 of 15), respectively, in detecting hepatic neoplasm and 93% accurate (in 14 of 15) when used together. When results of both studies were normal, hepatic neoplasm was present in 4% (one of 23 patients). The likelihood of hepatic neoplasm in the presence of a positive scan and elevated SAP level was 92% (in 11 of 12). No liver-function studies were helpful in eliminating the problem of false-negative scans. The presence of multiple space-occupying lesions without associated increased extrahepatic uptake was effective in differentiating hepatic neoplasm from cirrhosis. In 11 patients with lymphoma, increased splenic uptake of gold Au 198 occurred in seven. In some instances, this may have been related to hepatic involvement with lymphoma, and, in others, to increased phagocytic activity of the reticuloendothelial system of the spleen with or without splenomegaly.
Cognitive impairment and survival in very elderly people
Authors: P. Forster, E. Heckford, C. Huckler, N. Keong, A. Al-Khabaz, R. Rozzini, S. Franzoni, G. B Frisoni, M. Trabucchi, J Gussekloo, E J Remarque, A M Lagaay, D L Knook, R G J Westendorp, T J Heeren
Journal: BMJ (1998)

Data support extended use of levonorgestrel intrauterine systemsEditor-The levonorgestrel intrauterine system (Mirena), a useful addition to contraceptive choice, is now approaching its third anniversary.In the United Kingdom the product licence for the levonorgestrel intrauterine system permits its use for three years.In all other countries where the system is marketed, however, its use is approved for five years.There is good evidence to support this longer duration, 1 and indeed the system seems to remain effective for as long as seven years. 2 We understand that Schering Healthcare has applied for a two year extension to its current licence, backed by their new data that relates to the new polymer that has been used since 1990.Many clinicians have asked us if they should conform strictly to the current product licence and replace each intrauterine system on the third anniversary of its insertion.We would strongly advise delaying reinsertion in this time, at least until the expected statement from the Medicines Control Agency.It is well known that the process of insertion of all intrauterine contraceptives causes problems (short term inconvenience and discomfort followed by new bleeding and pain or expulsion) and also real risks, 3 4 notably perforation and upper genital tract infection.These would be unacceptable if it emerges that reinsertions were not necessary.Users of the levonorgestrel intrauterine system can be reassured that good data are available to support its use for five years.From 15 May, and until any statement concerning a change in the licence, continuation beyond three years is legitimate, at the woman's choice, provided the established criteria for use by named patients are observed-that is, explaining that this is unlicensed use of a licensed product; highlighting the risks and benefits of the proposed non-intervention; obtaining and recording the woman's verbal consent in her case notes; and keeping a separate record of the woman's name and the nature of the unlicensed use.
Effect of Horse Serum and Fetal Calf Serum on Stability of Chromosomes in Mouse Embryo Cells &lt;italic&gt;In Vitro&lt;/italic&gt;&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Ram Parshad, Katherine K. Sanford
Journal: JNCI Journal of the National Cancer Institute (1967)

Horse serum and fetal calf serum as supplements to chemically defined medium differentially influenced the stability of chromosomes in mouse embryo cells during growth in vitro. Cells from both C3Hf/HeN and germfree ALB-2T mice showed more chromosomal abnormalities in horse serum-supplemented medium than in Fetal calf-serum medium. Studies were carried out to explain the mechanism controlling this difference in karyotypic stability in the two types of serum. Four possibilities were discussed. Experiments on transfer of cells after 458 days in horse-serum medium to Fetal calf-serum medium indicated that fetal calf serum did not act selectively to eliminate cells with abnormal karyotype. Further, fetal calf serum appeared not to select from the initial mixed population cells less subject to chromosomal alteration. Instead, horse serum seemed to induce chromosomal breaks at a faster rate than did fetal calf serum. Also, it appeared that Fetal calf serum might fail to induce breaks or at least might protect chromosomes from undergoing breaks to a greater extent than horse serum.
Chromosome Studies in Chronic Lymphocytic Leukemia and Lymphosarcoma
Authors: P. H. Fitzgerald, Angela Adams
Journal: JNCI Journal of the National Cancer Institute (1965)

Chromosome studies are reported on 30 patients with chronic lymphocytic leukemia and 6 with lymphosarcoma. Direct techniques that avoid the use of culture were unsuccessful because of the rarity of dividing cells in vivo, and the examinations were made mostly on cultured leukocytes. Cell lines characterized by particular chromosome abnormalities were identified positively in only 1 patient with leukemia and 1 with lymphosarcoma, both of which had a particularly active neoplastic process. Apart from isolated instances of chromosome damage almost certainly due to therapy, there was no evidence of gross, acquired chromosome abnormality in the other 34 patients. Difficulties in the interpretation of these largely normal findings are discussed, and it is suggested that the cells of these relatively benign diseases may not carry gross chromosome abnormalities.
Update: Influenza Activity—United States, 1997-98 Season
Journal: JAMA (1998)

Influenza activity was low in the United States during October through early December but has increased steadily since mid-December. Current surveillance indicators suggest that influenza activity for the season has not yet peaked. Laboratory-confirmed influenza infections have been reported from 45 states, and this season's influenza vaccine strains have been well matched antigenically to the influenza viruses isolated so far this season. In response to this season's influenza vaccine supply shortage, the Department of Health and Human Services (DHHS) has purchased 1.2 million doses of 2004-05 inactivated influenza vaccine from GlaxoSmithKline (GSK). The GSK vaccine is produced, licensed, and distributed globally but is not licensed for use in the United States; therefore, it will be administered in the United States under an Investigational New Drug (IND) protocol. This report summarizes influenza activity during October 3, 2004-January 1, 2005 and provides information on the availability of additional influenza vaccine from GSK.
Chemical Pathology. Being a Discussion of General Pathology from the Standpoint of the Chemical Processes Involved.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Juvenile Rheumatoid Arthritis
Authors: John J. Calabro, Joseph M. Marchesano
Journal: New England Journal of Medicine (1967)

RHEUMATOID arthritis remains the major chronic and progressive crippling disease of childhood. In the United States alone, there may be as many as 175,000 cases, but this is only a rough estimate, since no survey of any chronic children's disease has ever been undertaken. Recent investigations, though chiefly descriptive, have added greatly to therapeutic judgment in the management of this disease. Yet as management has improved, certain basic problems, especially concerning etiology, seem no closer to being understood than they were some decades ago.The Etiologic PuzzleThe cause of juvenile rheumatoid arthritis remains unknown, although infection, autoimmunity, trauma or . . .
The Archives of Family Medicine
Authors: George D. Lundberg
Journal: JAMA (1992)

The American Medical Association (AMA) announces its first new scientific journal since 1926. The<i>Archives of Family Medicine</i>will be sent monthly on a complimentary basis to approximately 83000 family physicians and general practitioners in the United States in addition to being available on a paid subscription basis to anyone, anywhere. Under the leadership of Marjorie A. Bowman, MD, professor and chair of family and community medicine at the Bowman Gray School of Medicine, an outstanding editorial board, and Associate Publisher Michael Springer, thisArCHIVESwill deliver peer-reviewed, primary source, scientific and clinical articles, reviews, and articles on practice management, prevention, health promotion, and technology assessment, as well as timely commentaries on ethical, social, economic, and political issues. The editors will serve the information needs of frontline family physicians and will use reader-friendly language and design to deliver the messages in the most palatable manner possible. Credit for this initiative
Hodgkin's Disease
Authors: Alastair J.J. Wood, Vincent T. DeVita, Susan Molloy Hubbard
Journal: New England Journal of Medicine (1993)

Radiotherapy is curative for localized Hodgkin's disease,1,2 and there is now general agreement that advanced Hodgkin's disease can be cured by chemotherapy. This opinion is bolstered by the 20-year survival experience of the original group of patients treated with combination chemotherapy at the National Cancer Institute (Figure 1) and by experience with other regimens (Table 1)29.Therapy According to Disease StageDisease stage is the principal factor in selecting treatment for patients with Hodgkin's disease. The Ann Arbor system of classification is shown in Table 22. Although they are far outweighed by the benefits of successful treatment, there . . .
Awards, Appointments, Announcements
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Awards, Appointments, Announcements Get access JNCI: Journal of the National Cancer Institute, Volume 82, Issue 21, 7 November 1990, Pages 1676–1678, https://doi.org/10.1093/jnci/82.21.1676 Published: 07 November 1990
A Manual of Diseases of the Nose, Throat and Ear.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Refractory Supraventricular Arrhythmias in the Elderly
Authors: Barry M. Beller
Journal: JAMA (1971)

Five elderly patients, disabled by recurrent episodes of bradycardia and supraventricular tachycardia, have been successfully treated with combined permanent demand ventricular pacing and cardiac drugs as indicated. Recurrent episodes of bradycardia and asystole have been totally eliminated and supraventricular tachycardia has not recurred as long as the patients have continued their medication. Case histories and electrocardiograms of the patients are presented and the electrophysiology is discussed. The medical and economic benefits derived from the prompt application of this form of therapy is emphasized.
The Physician's Visiting List.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MCAT: Desperately Seeking Med School
Authors: Bruce B. Dan
Journal: JAMA (1988)

I AM not certain why I decided to take the Medical College Admission Test (MCAT) again, 18 years after my first confrontation with it. Perhaps it was idle curiosity or perhaps a desire to see firsthand what changes had occurred in the test (or in me) so many years later. My attempt at repeating the exam wouldn't be the first such try. Robert Powers<sup>1</sup>had previously published an insightful and carefully documented account of a similar endeavor. In fact, in reading his essay, I am struck by how closely his observations parallel my own. See also p 389. Like Powers, I thought that I might be an apt guinea pig for this uncontrolled adventure. Over the years, I have been asked to submit to virtually every optically scanned multiple-choice English-language examination that educators have yet devised. Since the 10th grade, I have taken the following in chronological order: Essential
Editorial board and contents
Authors: De-Xing Zhang, Don Moll, Edward Moll, Graeme Hays, Rama Singh, Marcy Paul, David Penny, Matthew Phillips, Kelly Lee, Kirk Klasing, Steven Peck, Pamela Anderson, Andrew Cunningham, Nikkita Patel, Francisco Morales, Paul Epstein, Peter Daszak, Andrew Shedlock, Kazuhiko Takahashi, Norihiro Okada, Herman Mays, Geoffrey Trendsin, Katrina Lythgoe, Linsey Stapley, Catherine Hughes, Manager Moulton
Journal: Trends in Ecology & Evolution (2004)
The Physician's Visiting List for 1894.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights of This Issue
Journal: Clinical Cancer Research (2011)

CLDN4, a cell tight junction protein, is highly expressed in most ovarian cancers, but is expressed at low levels in normal tissues.Here, Gao and colleagues used the noncytotoxic small molecule C-CPE as a CLDN4targeted delivery vehicle to selectively open cellular tight junctions and potentiate chemotherapy delivery into ovarian cancer cells.C-CPE sensitized CLDN4-expressing tumor xenografts to low-dose Taxol and suppressed tumor growth without inducing overt toxicity in animals.Further, this treatment was highly specific to CLDN4-positive ovarian cancer cells vs. CLDN4-negative cancer cells or nonneoplastic cells.This therapeutic strategy may have important implications for enhancing efficacy of conventional chemotherapy. Highlights
Highlights from Recent Cancer Literature
Journal: Cancer Research (2013)

Secreted PTEN as a Therapeutic in cancerPhosphoinositide 3-kinase (PI3K) is a lipid phosphatase activated prominently in cancer, frequently though deletion of the negative regulator, PTEN, which encodes a lipid phosphatase.Hopkins and colleagues have identified an evolutionarily conserved alternative start codon upstream and inframe of PTEN's normal start codon.Protein translation beginning at this site would produce a protein, which they termed PTEN-Long, with an additional 173 amino acids at the amino terminus of PTEN.Using antisera to PTEN-Long and through tagging experiments, they show PTEN-Long is a secreted protein that is membrane permeable and retains lipid phosphatase activity.Treatment of PTEN-mutant malignant glioma cells with purified PTEN-Long protein antagonized PI3K signaling in cell culture and in flank xenografts, leading to apoptosis in vitro and in vivo.A control preparation of PTEN-Long defective in lipid phosphatase activity showed no activity.This remarkable discovery provides a potential means to block PI3K activity in vivo by administration of a secreted form of PTEN protein.(Image courtesy of
Method for the Determination of &lt;italic&gt;N&lt;/italic&gt;-Nitros-amines in Tobacco-Smoke Condensate&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: John W. Rhoades, Donald E. Johnson
Journal: JNCI Journal of the National Cancer Institute (1972)

Journal Article Method for the Determination of N-Nitros-amines in Tobacco-Smoke Condensate Get access John W. Rhoades, John W. Rhoades Department of Chemistry and Chemical Engineering, Southwest Research Institute, San Antonio, Texas 78284 Search for other works by this author on: Oxford Academic PubMed Google Scholar Donald E. Johnson Donald E. Johnson Department of Chemistry and Chemical Engineering, Southwest Research Institute, San Antonio, Texas 78284 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 48, Issue 6, June 1972, Pages 1841–1843, https://doi.org/10.1093/jnci/48.6.1841 Published: 01 June 1972
Saphenous Vein Bypass Surgery for Impending Myocardial Infarction
Authors: Bernard L. Segal
Journal: JAMA (1973)

Seventeen patients considered to have impending myocardial infarctions were subjected to saphenous vein bypass operation. Each patient had experienced recurrent angina pectoris with electrocardiographic changes of transient ischemia, but no infarction and no enzyme abnormalities. Paroxysmal ventricular tachycardia had occurred in seven patients, and ventricular fibrillation and cardiac arrest in two more. Two patients received triple grafts, 12 received double grafts, and three received only one graft. Three died and three experienced acute myocardial infarctions during operation. Follow-up study revealed that angina pectoris was absent in all patients except one; 11 patients returned to full-time employment, and no arrhythmias recurred. Patency of graft was noted in 85%, or 28 of 35 grafts. The operation may be advised for patients with impending myocardial infarction, as well as for those with life-threatening arrhythmias unresponsive to antiarrhythmic agents.
Anesthesiology Comes of Age
Authors: Emanuel M. Papper
Journal: JAMA (1989)

ANESTHESIOLOGY came into being during my professional lifetime, achieving recognition as a specialty in the decade prior to World War II. The war brought about profound changes in many areas of medicine, including anesthesiology, and some of these changes persist in current practice. My decision to embark on a career in a field that in 1938, the year I graduated from medical school, was so new it had hardly been recognized by organized medicine was largely dictated by chance. I was one of those young men who were not sure that a career in any special branch of medicine would be gratifying, especially since the mind-set of my generation leaned toward general practice. Since my intentions were not firmly set when I chose to become a medical student at New York (NY) University School of Medicine, I spent much of my spare time doing research in nutrition and diabetes with
Nursing in transition. Challenge for the future
Authors: F. C. Macgregor
Journal: JAMA (1966)

The perspective of this paper is that of a social scientist whose professional involvement with nurses, doctors, and patients has spanned more than a decade. The very selection and nature of my research and teaching, namely the psychosocial and cultural aspects of illness and patient care, and the time spent as participant-observer in medical settings imply a special interest and value perspective. Additionally, my long association with nursing education in the United States has led inevitably to identification with and concern about the problems I have chosen to discuss here in the context of current world conditions and what they seem to portend. Paramount among these problems and encompassing them all, I believe,<i>is the danger of progressive depersonalization of patients, and, concomitantly, of nurses as well</i>. This statement in no way minimizes the achievements of nursing to date in widening its focus from concern with the body of the