POS0974 CARDIOVASCULAR OUTCOMES OF ANTI-TNF ALFA AND JAK INHIBITORS IN PATIENTS WITH RHEUMATOID AND PSORIATIC ARTHRITIS. REAL WORLD EVIDENCE AND INSIGHTS OF BIOBADASAR 3.0 REGISTRY
Authors: J. A. Brigante, K. Roberts, C. A. Isnardi, G. Gómez, L. L. Holguín Arias, B. Pons-Estel, J. Gamba, M. Haye, J. M. Dapeña, A. Secco, V. Savio, C. Soliz Cordero, C. Gobbi, E. Velozo, E. Catay, N. Aste, G. Medina, I. E. Exeni, G. Gomez, D. A. Pereira, A. B. Granel, I. Petkovic, C. Pisoni, A. M. Smichowski, M. Sacnun, G. Berbotto, M. García, M. Viola, G. Bovea Castelblanco, V. Saurit, E. Kerzberg, M. S. Larroude, M. E. De La Sota, A. Bertoli, M. P. Diaz, C. Castro, G. Citera, G. Casado, R. Quintana, E. Soriano, C. Graf, G. Pons-Estel, M. De la Vega
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Major Cardiovascular Adverse Events (MCAE) are a concern in autoimmune diseases. Rheumatoid Arthritis (RA) and psoriasis arthritis (PsA) are diseases where inflammation plays a vital role in developing the disease and producing short- and long-term damage. The TNF alpha plays a significant role in inflammation. The JAK/STAT signaling pathway is an essential regulatory signaling cascade of intracellular processes used in treating these conditions. It is crucial to evaluate the effect of these treatments on long-term comorbidities associated with these diseases. <h3>Objectives</h3> This study aims to provide real-world evidence on the influence of Anti-JAK, Anti-TNFa, and cs-DMARDs therapy on cardiovascular events in RA and PsA. <h3>Methods</h3> Data from the BIOBADASAR 3.0 registry of patients diagnosed with RA and PsA (ACR-EULAR 2010/ CASPAR 2006) from June 2010 to May 2022. This data was recollected from patients treated with cs-DMARDs (control group), Anti-TNF alpha, and JAK inhibitors. The history of specific comorbidities and the appearance of AE were recorded. Kaplan Meier curves evaluated event-free survival time, and the comparison between the different treatments was performed by Log Rank analysis. Additionally, to account for alternative explanations, a propensity score (PS) was estimated, which assigned a value to each observation according to the probability of incorporating all the information available to estimate this probability and making the groups associating similar patients more comparable. <h3>Results</h3> Of 6,209 patients, 4,817 (77.6%) with RA and 510 (8.2%) with PsA were studied. The overall frequency of MCAE was 48 (2.2%) in the Anti-TNFa group, 5 (2.37%) in the Anti-JAK group, and 38 (1.84%) in the control group (p=0.6). MCAE-free survival was a median in years of 3.02 for the Anti-TNFa group (HR 1.3 95%CI 0.8-384), 5.1 for the control group (HR 1.5 95%CI 0.32-651), and 1.8 for the group with JAK inhibitors (HR 3.02 95% CI 0.2-0.8), The results of the regression model adjusted by PS to present MCAE were for the Anti-TNFa group HR 1.28 IC95% 0.77-2.13 p 0.34, for the non-exposed group HR 1.48 IC95% 0.82-2.67 and the JAK inhibitor group 3.12 IC95% 1.48-6.6 p &lt; 0.001. <h3>Conclusion</h3> In conclusion, we found no statistically significant difference between the RA and APS groups appearance of adverse events of interest. In this study, we observed a higher MCAE-free survival time in the not exposed group than in the Anti-TNFa group and considerably low in the Anti-JAK group with a statistically significant difference. These differences persist in the multivariate model adjusted by propensity score. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> Jorge Alejandro Brigante Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Karen Roberts Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Carolina Ayelen Isnardi Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Gimena Gómez Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Laura Lucia Holguín Arias Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Bernardo Pons-Estel Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., JULIETA GAMBA Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Maria Haye Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Joan Manuel Dapeña Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Anastasia Secco Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Veronica Savio Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Carola Soliz Cordero Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Carla Gobbi Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Edson Velozo Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Erika Catay Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Nora Aste Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Gustavo Medina Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Ida Elena Exeni Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Graciela Gomez Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Dora Aida Pereira Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Amelia Beatriz Granel Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Ingrid Petkovic Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Cecilia Pisoni Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Andrea Maria Smichowski Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., MONICA SACNUN Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Guillermo Berbotto Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Mercedes García Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Malena Viola Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Gladys Bovea Castelblanco Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Veronica Saurit Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Eduardo Kerzberg Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Maria Silvia Larroude Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Mercedes Elena De La Sota Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Ana Bertoli Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Monica Patricia Diaz Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Cecilia Castro Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Gustavo Citera Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Gustavo Casado Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Rosana Quintana Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Enrique Soriano Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Cesar Graf Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Guillermo Pons-Estel Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database., Maria de la Vega Grant/research support from: BIOBADASAR has received an unrestricted Grant from Pfizer. Pfizer has not participated in or influenced the project's development, data collection, analysis, interpretation, or report writing. They do not have access to the information collected in the database.