tbuckley/cabot-search huggingface dataset:
Pharyngeal Gonorrhea
Authors: Gary M. Zaret
Journal: JAMA (1982)

<h3>To the Editor.—</h3> The recent article by Tice and Rodriguez, "Pharyngeal Gonorrhea" (1981;246:2717), states that "The USAF Regional Medical Center, Clark AFB, Republic of the Philippines, has undertaken venereal disease surveillance of the registered prostitutes in adjacent communities for several years. In addition, cultures for gonorrhea have been obtained... from symptomatic men seen in the Clark Public Health Clinic." During the study period, 110 cultures positive for<i>Neisseria gonorrhoeae</i>were obtained from 903 prostitutes. The authors state, "The only patients available for follow-up were those from the Clark Public Health Clinic," while the abstract contains a statement that "Treatment and follow-up of the pharyngeal infections were available only for the men seen at the Clark Public Health Clinic." Clearly, one could obtain the impression that the prostitutes involved in the study might not have received treatment. If they were indeed treated for their infections, the form of treatment and numbers
Self-reported pelvic inflammatory disease in the United States, 1988
Authors: S. O. Aral
Journal: JAMA (1991)

<h3>Objective.</h3> —To assess any changes in the characteristics of women with self-reported pelvic inflammatory disease (PID) between 1982 and 1988 and to evaluate the role of additional behavioral factors. In 1982, PID was a frequent problem among American women of reproductive age, occurring in one in seven. It was also more common among older (≥30 years) than younger women, more common among blacks than among whites, and more common among formerly married women than among those currently married. <h3>Design.</h3> —We analyzed data on self-reported PID from the cycle IV National Survey of Family Growth, conducted in 1988. <h3>Sample.</h3> —The survey was conducted with a multistage probability sample of 8450 women. <h3>Results.</h3> —The findings from 1982 were all replicated. Additional variables available in 1988 show that PID is more common among women with multiple (two or more) sexual partners (10% to 22%) compared with those with only one lifetime partner (7%) and among women who report a history of sexually transmitted disease (STD) (26%) compared with those with no STD history (10%). Controlling for other variables, age, race, vaginal douching, age at first intercourse, STD history, and number of lifetime partners emerged as independent predictors of self-reported PID among American women of reproductive age. <h3>Conclusion.</h3> —PID is still a widely prevalent condition among American women; PID is associated with a variety of risk factors for STD. Prevention of lower genital tract infection is crucial to avoiding PID and its sequelae. (<i>JAMA</i>. 1991;266:2570-2573)
Severity of Health Effects Associated with Building-Related Illness
Authors: Laura S. Welch
Journal: Environmental Health Perspectives (1991)

Building-related illness ranges from mild rhinitis to potentially life-threatening hypersensitivity pneumonitis and legionellosis. Sick-building syndrome, consisting of headache, mucous membrane irritation, and fatigue, may be present in 30% of all office workers. Hypersensitivity pneumonitis, asthma, and legionellosis are less common, and it is difficult from existing studies to estimate the incidence of these more severe illnesses. There are even fewer data on an illness now being called multiple chemical sensitivity and its relationship to indoor environments. New studies are needed to estimate the frequency of all building-associated illnesses, and case definitions for these disorders must be delineated.
Thyroid function screening in psychiatric patients
Authors: K. L. Cohen
Journal: JAMA (1979)

Abnormalities in levels of total thyroxine and thyroxine binding capacity were common in a group of 480 newly admitted psychiatric patients. The estimated free thyroxine (EFT<sub>4</sub>) level was elevated in 43 patients (9%). In 27 of these patients, the level of EFT<sub>4</sub>became spontaneously normal, usually within a two-week period (acute "stress hyperthyroidism"). The level of EFT<sub>4</sub>was decreased in 42 patients (9%). In 16 of these patients, the level became spontaneously normal; the etiology of this apparent acute hypothyroidism is unclear. The yield of new cases of primary hyperthyroidism and hypothyroidism was low, but a presumptive diagnosis of secondary hypothyroidism was made in eight patients. In addition, nine patients with known thyroid disease were taking inadequate or excessive replacement therapy. Thyroid function screening tests are of value in psychiatric patients. (<i>JAMA</i>242:254-257, 1979)
<i>Announcement</i>: Healthy and Safe Swimming Week — May 23–29, 2016
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

May 23-29, 2016, marks the 12th annual Healthy and Safe Swimming Week.* This observance highlights ways that swimmers; parents of young swimmers; aquatic facility operators; residential pool, hot tub, or spa owners; beach managers; and public health officials can maximize the health benefits of water-based physical activity while minimizing the risk for recreational water-associated illness and injury.
Update in Rheumatology
Authors: David B. Hellmann, John B. Imboden
Journal: Annals of Internal Medicine (2006)

Updates5 December 2006Update in RheumatologyDavid B. Hellmann, MD and John B. Imboden, MDDavid B. Hellmann, MDFrom Johns Hopkins University, Baltimore, Maryland, and University of California San Francisco, San Francisco, California.Search for more papers by this author and John B. Imboden, MDFrom Johns Hopkins University, Baltimore, Maryland, and University of California San Francisco, San Francisco, California.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-145-11-200612050-00008 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This year's Update in Rheumatology includes discussions of advances related to rheumatoid arthritis, systemic lupus erythematosus, Wegener granulomatosis, antineutrophil cytoplasmic antibody–associated vasculitis, and gout. Changes to clinical practice emerging from these articles are shown in the Table.Table. Changes to Clinical Practice Emerging from Articles Important to Rheumatologists in 2005*Rheumatoid ArthritisInitial Combination Therapy Limited Damage and Resulted in Functional Improvement in Early Rheumatoid Arthritis Goekoop-Ruiterman YP , ...Reference1. Lustberg ME. Febuxostat versus allopurinol for gout [Letter]. N Engl J Med. 2006;354:1532-3; author reply 1532-3. [PMID: 16598054] Google Scholar Author, Article, and Disclosure InformationAffiliations: From Johns Hopkins University, Baltimore, Maryland, and University of California San Francisco, San Francisco, California.Grant Support: In part by the Rosalind Russell Arthritis Research Center.Disclosures: None disclosed.Corresponding Author: David B. Hellmann, MD, Department of Medicine, Room 109, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, B-1-North, Baltimore, MD 21224; e-mail, [email protected]edu.Current Author Addresses: Dr. Hellmann: Department of Medicine, Room 109, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, B-1-North, Baltimore, MD 21224.Dr. Imboden: Department of Medicine, University of California, San Francisco, Box 0868, San Francisco, CA 94143. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byWegener’s granulomatosis: an update on diagnosis and therapyIntracellular protease activation in apoptosis and cell-mediated cytotoxicity characterized by cell-permeable fluorogenic protease substrates 5 December 2006Volume 145, Issue 11Page: 834-838KeywordsCyclophosphamideDrugsGoutLupus erythematosusMethotrexateOral contraceptive therapyRheumatoid arthritisVasculitisWegener granulomatosis ePublished: 5 December 2006 Issue Published: 5 December 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Antimicrobial Therapy for Otitis Media With Effusion: The Pittsburgh Response-Reply
Authors: Ellen M. Mandel
Journal: JAMA (1993)

<h3>In Reply.</h3> —Dr Cantekin has responded to virtually none of the substance of our article, but instead advances invalid accusations and other misleading statements. First, as for "special oversight," the OSI noted that "the recommendations concerning operations of the OMRC were not intended as sanctions..." but "were intended to provide safeguards against even the appearance of possible conflict of interest..."<sup>1(p3)</sup>The OSI did not find that Dr Bluestone had "financial ties to drug companies." Dr Bluestone had received research support from drug companies and honoraria for presentations at scientific and educational meetings, but the OSI did not find that these funds were "undisclosed." The OSI also did not find "bias."<sup>2</sup> Second, the OSI commentary on antibiotic therapy now cited by Cantekin referred not to our<i>New England Journal of Medicine</i>article<sup>3</sup>that Cantekin and his coauthors had criticized<sup>4</sup>and that our<i>JAMA</i>article defended, but rather
Underwater Drugstore
Authors: Robert Watson
Journal: Environmental Health Perspectives (1994)

the CENR prepared preliminary strategies for establishing scientific approaches and short-term priorities for seven programmatic and three cross-cutting issue areas in which to address the administration's concerns about federal R&D efforts.The programmatic issues include air quality, biodi- versity and ecosystems, global change, nat- ural disasters, resource use and manage- ment, toxic substances and hazardous and solid waste, and water resources, coastal, and marine environmental research.The three cross-cutting issues are risk assess- ment, social and economic sciences, and technology and engineering.The areas outlined in the preliminary strategic plans will provide the structure for addressing key weaknesses in federal R&D that have been raised in a number of reports over the last two years, including program integration, interagency cooperation, links to the policy formulation process, partnerships with industry and academia, research approaches that address long-term scientific issues as well as shortterm management and regulatory requirements, need for expanded federal efforts in the biological and social sciences, and human resource development.
The American Medical Association.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Present status of interstitial irradiation in managing prostatic cancer
Authors: R. H. Flocks
Journal: JAMA (1969)

Prostatic carcinoma can be divided into four stages as it is seen clinically, as follows: (1) A stage A lesion is occult. (2) A stage B lesion is completely limited to the prostate and is relatively small. (3) A stage C lesion invades the capsule and partially invades the areolar tissue around the prostate itself and around the base of the seminal vesicles, with no evidence of lymph-node or vascular metastases, and includes lesions which are larger than stage B lesions with extensive invasion around the bladder neck and the base of the seminal vesicles, but again with no evidence of distant metastases. (4) A stage D lesion has vascular metastases and lymph-node metastases. This clinical staging, it is to be emphasized, is subject to much correction, since recent studies indicate that approximately 5% of stage A and B lesions have either vascular or lymphatic lesions, that 45% of stage
HIV Infections Attributed to Male-to-Male Sexual Contact—Metropolitan Statistical Areas, United States and Puerto Rico, 2010
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genito-Urinary Diseass nd Syphils.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In This Issue/Research Watch/News-in-Brief/News from the IASLC Tobacco Control Committee
Journal: Journal of Thoracic Oncology (2019)

This study compares the impact of doses and fractionation schedules of thoracic radiation with concurrent cisplatin based chemotherapy on the risk of developing brain metastasis in patients receiving prophylactic cranial irradiation (PCI) for limited stage small cell lung cancer.This is a secondary analysis of the multicenter phase III Concurrent ONce-daily VErsus twice-daily RadioTherapy (CONVERT) trial.449 of 547 (82%) patients received PCI; 220 out of 273 (81%) in the twice daily (BD) group and 229 out of 270 (85%) patients in the once daily (OD) group (P¼0.49).Of 449 patients, 40 patients in the BD group (9%) and 35 patients in the OD group (8%) developed brain metastases.There was no significant difference in the risk of developing brain metastasis between BD and OD radiation fractionation (P¼0.74).Median overall survival (OS) in the PCI group was 29 months; in the BD group was 28 months and 31 months in the OD group (95% CI: 27e52 months; P¼ 0.1).Median OS in the non-PCI group was 11.8.In multivariate analysis, thoracic gross tumor volume and ECOG performance score were associated with brain as well as extracranial metastasis, whereas, only larger thoracic tumor volume was associated independently with overall survival.In conclusion, this trial showed that larger tumors, and not thoracic radiation fractionation, are associated with a higher risk of brain as well as extracranial metastasis.(p.294) Disparities in the Diagnosis and Treatment of Lung Cancer among People with DisabilitiesThis is a retrospective cohort study to evaluate potential disparities in diagnosis, treatment, and outcomes of lung cancer patients for people with physical, mental/cognitive, or communication disabilities using a population database.A sample of 1180 patients with disabilities was compared with 4385 matched controls using the Korean Central Cancer Registry and the national disability registration database.Patients with disabilities had higher rates of incomplete staging (13.1% vs 10.3%); this was more pronounced in patients with mental (15.7%) and communication (14.2%) disabilities.Patients with disabilities were also less likely to undergo surgical procedures (19.8% vs 21.9%; aOR 0.82, 95% CI: 0.77e0.86),and were less likely to receive chemotherapy (aOR 0.80, 95% CI: 0.77e0.84),or radiotherapy (aOR 0.92, 95% CI: 0.88e0.96).Despite these discrepancies, patients with disabilities had only a slightly higher rate of mortality than those without disabilities (aOR 1.08, 95% CI: 1.06e1.11),albeit higher mortality in patients with severe disabilities (grade 1 to 3 in the Korean classification system) (aOR 1.20, 95% CI: 1.16e1.24).This study highlights the need to address these disparities in care of lung patients with disabilities and design approaches to treat them.(p.163)
Lecture on the Diseases of Children: Delivered in the Chatham Street School of Medicine, Manchester
Authors: None Merei
Journal: BMJ (1852)

In this way it will be possible to administer large at the University of Pesth, Clinical Professor of the Diseases of Children, doses of the remedy, which otherwise easily cause andDirector of the Children's Hospital at Peoth; Fellow of the Imperial nausea, vomiting, gastric, or intestinal pains, and Society of Medicine at Vienna, etc. diarrhoea.The tolerance of it, however, being verydifferent, I almost always commence with one teaspoon- ful as a single dose, four or six times a day, and in-Speciacad kermse aiicrmedies.ulphdohate of aopper, ds crease the quantity gradually, as far as the idiosyncrasy loia, mermes, a iodine hanthenofcop xer,na allows it.Many children, from about nine to fourteen liver oil, mercutry, iodine, anthelmentics.External .emedies.years old, could take of this mixture one tablespoonful four or five times a day, or about four to six grains of it, GENTLEMEN, -Hydrochlorate of Ammonia (Sa7 and continue this during some weeks, whilst in powder ammoniac) is a remedy used throughout all Germany, we scarcely succeed with more than half a grain per Italy, and Hungary, as the most effective in bronchitis.dose.When sickness is produced, we cease with it for An extensive trial and observation has satisfied me one day, and then lessen a little the doses.as to its good effects, and I recommend it to you Cod-liver oil, is the real specific of atrophy without
PWE-038 Utility of measuring infliximab drug levels and anti-drug antibodies in clinical practice: a large ibd referral centre experience
Authors: EL Johnston, BD Warner, JL Digby-Bell, N Unsworth, S Anderson, JD Sanderson, Z Arkir, PM Irving
Journal: Gut (2015)

<h3>Introduction</h3> The development of infliximab (IFX) drug level and anti-drug antibody (ADA) testing has allowed a personalised approach to IFX use in inflammatory bowel disease (IBD). We present our 2-year experience at a tertiary IBD centre. <h3>Method</h3> All IFX drug and ADA levels measured in patients managed at the Guy’s and St. Thomas’ IBD centre were reviewed. Indications for carrying out drug levels, subsequent changes in management and long-term outcomes were evaluated. <h3>Results</h3> 330 levels were measured in 199 patients from May 2012 to October 2014. Median IFX levels were 4.1 (range 0- &gt;8 µg/ml). 109 (33%) levels were sub therapeutic (≤2.0 µg/ml), of which 61 patients were symptomatic. This resulted in a change in management in 44 (72%) of those patients. ADA were detected in 22 tests (7%) from 19 patients. 12 patients were switched to adalimumab of which 11 continue (median 11 months follow-up) and 1 was a primary non-responder. 4 patients continued on IFX but were optimised on thiopurines, only 1 of which had a subsequent improvement in disease activity. 1 patient stopped anti-TNF therapy due to demyelination, and 2 discontinued anti-TNF to take part in clinical trials. 121 levels (37%) were measured in patients with loss of response (LOR) of whom 50 (41%) had sub therapeutic levels (&lt;2.0 µg/ml). 27 patients, all with no detectable antibodies, underwent dose escalation. 32 levels (10%) were measured at week 14 after standard induction of IFX resulting in 3 patients being switched to adalimumab (Ada) due to significant antibody detection (&gt;200 U/ml) and 1 patient having their dose increased to 10 mg/kg due to borderline levels (2.0 µg/ml) along with poor clinical response. 97 levels (29%) were measured as part of annual reassessment resulting in only 8 changes in management. 1 patient with levels &gt;8 µg/ml had a de-escalation from 10 to 5 mg/kg and 3 had their dose increased due to low levels. As a result of inactive disease, 4 out of the 81 patients with therapeutic IFX levels were able to be withdrawn. The remaining levels were measured after a change in dose of IFX (17%) or for consideration of: withdrawal of concomitant immunosuppression (1%), dose reduction (3%) and withdrawal from IFX (3%). <h3>Conclusion</h3> IFX drug and antibody level testing is being increasingly used in clinical practice. The benefits seem greatest in patients with LOR although our understanding of their utility in other circumstances is increasing. <h3>Disclosure of interest</h3> E. Johnston: None Declared, B. Warner: None Declared, J. Digby-Bell: None Declared, N. Unsworth: None Declared, S. Anderson: None Declared, J. Sanderson: None Declared, Z. Arkir: None Declared, P. Irving Speaker Bureau of: MSD, Abbvie and Takeda.
Plight of Doctors in the Central African Federation
Journal: BMJ (1964)

the absurdly low salaries paid to hospital junior medical staff.He has also unfortu- nately an extremely low opinion of general practitioners and the work they do.He seems to subscribe to the " your life in their hands " type of thinking, whereby the glamour and therefore importance of surgery outweighs the routine and the humdrum.No one has said that general practitioners do 90% of the work.What they do is to deal with 90% of the people wanting medical advice.The 10% that they have to refer is in no general practitioner's opinion inferior or less time-consuming that the cases they deal with themselves.No general practitioner would equate the prescribing of an expectorant to the saving of a man's life by the removal of an extra- dural haematoma; just as no surgeon would
Real World Data On Primary Treatment For Mantle Cell Lymphoma 2000-2011 – a Nordic Lymphoma Group Observational Study
Authors: Anna Abrahamsson, Alexandra Albertsson Lindblad, Peter de Nully Brown, Stefanie Baumgartner Wennerholm, Lars Moller Pedersen, Francesco d'Amore, Herman Nilsson-Ehle, Paw Jensen, Michael Pedersen, Christian H. Geisler, Mats Jerkeman
Journal: Blood (2013)