tbuckley/cabot-search huggingface dataset:
Cetuximab plus irinotecan for metastatic colorectal cancer (mCRC): Safety analysis of the first 400 patients in a randomized phase III trial (EPIC)
Authors: A. Sobrero, W. Scheithauer, J. Maurel, L. Mineur, L. Fehrenbacher, O. Kisker, J. Kopit, C. Langer, M. Schlichting, Y. Abubakr
Journal: Journal of Clinical Oncology (2005)

3580 Background: The EPIC trial is a randomized phase III study comparing cetuximab plus irinotecan to irinotecan in 2nd-line metastatic, EGFR-expressing colorectal cancer (CRC) patients (pts). A pre-planned safety assessment of the first 400 randomized patients was performed. Methods: Patients with EGFR-expressing mCRC who had failed 1st-line oxaliplatin in combination with a fluoropyrimidine therapy with an ECOG performance status ≤ 2 were randomized to either Arm A (cetuximab 400 mg/m2 followed by 250 mg/m2 weekly dose and irinotecan 350mg/m2 q 3 weeks) or to Arm B (irinotecan 350mg/m2 q 3 weeks). A pooled analysis of safety is presented. Results: Four hundred pts were randomized from May 2003 to July 2004 in the US, Europe and Australia, 162 women and 238 men, with a median age of 61 years. Eleven patients did not receive study therapy and are excluded from the analysis. A total of 1493 cycles were administered to the 389 pts with a median of 3 cycles per pt (range 1–18). Four (1%) severe infusion reactions (IR) occurred. All were grade 3 and none were fatal. In this pooled analysis, 24 deaths occurred within 30 days of last study therapy: 17 were disease-related, 2 were study drug- related (both due to neutropenia), 4 were classified as “other causes” and 1 was “unknown”. A summary table of adverse events (AE) is below. Conclusions: In this pooled analysis the characteristic toxicities of cetuximab and irinotecan do not appear to be increased. The incidence and severity of these events appear comparable to previous reports of cetuximab with chemotherapy or of irinotecan. The study is continuing to accrue to its target of 1300 patients. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Bristol-Myers Squibb Bristol-Myers Squibb Aventis, Merck, Pfizer
Heparin-hepatocyte growth factor complex with low plasma clearance and retained hepatocyte proliferating activity
Authors: Y Kato
Journal: Hepatology (1994)

Because hepatocyte growth factor is known to have affinity for heparin, we studied the binding isotherm and found that hepatocyte growth factor has a high-affinity binding site for 35S-heparin with an equilibrium dissociation constant of approximately 0.6 nmol/L. We then analyzed the pharmacokinetic behavior of the heparin–hepatocyte growth factor complex in rats. The area under the plasma concentration-time profiles of trichloroacetic acid–precipitable radioactivities from 0 to 30 min after the intravenous administration of the heparin–125I-hepatocyte growth factor complex was approximately three times that after the administration of 125I-hepatocyte growth factor only. Because we previously demonstrated that the liver is the major clearance organ for hepatocyte growth factor, the hepatic uptake of 125I-hepatocyte growth factor and the heparin–125I-hepatocyte growth factor complex was compared. The liver-to-plasma concentration ratio after the intravenous administration of the complex was half that after the administration of 125I-hepatocyte growth factor only. Furthermore, the steady state hepatic extraction ratio of 125I-hepatocyte growth factor in perfused rat liver decreased depending on the heparin concentration. In addition, the biological activity of the complex was examined by assessing the 125I-deoxyuridine incorporation in cultured rat hepatocytes. Although the half-effective concentration of hepatocyte growth factor increased slightly–namely, two to three times in the presence of heparin compared with that in its absence–the maximal activity was not changed. We conclude that the heparin–hepatocyte growth factor complex, which retains biological activity, exhibits much lower clearances for hepatic uptake and plasma disappearance than hepatocyte growth factor itself. The heparin–hepatocyte growth factor complex may thus be utilized as a drug delivery system for hepatocyte growth factor. (Hepatology 1994;20:417–424.)
IMMUNITY.CHAPTER XXVII (Concluded).
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PNEUMONIC FEVER—ITS SYMPTOMATOLOGY.
Authors: EDWARD F. WELLS
Journal: JAMA (1894)

DIGESTIVE SYSTEM. During the chill or rigor there may be chattering of the teeth, and this usually augurs a severe attack. In one of my cases incessant and prolonged chattering occurred without the presence of a chill or general rigor, but this is rare. A man, aged 65, was awakened at midnight with uncontrollable chattering of the teeth. I saw him within an hour and found him in a great state of nervous excitement and alarm. His subjective symptoms were a feeling of uneasiness and an indefinite dread of impending evil. The skin was pale, pinched and cool; pulse 96, respirations 20, and temperature 99 degrees. He was restless, tossed about in bed, passed his urine frequently, and his teeth chattered incessantly and uncontrollably. This latter continued for more than two hours, subsiding gradually. Although the skin was cool, yet there was neither chilliness nor rigors. The ordinary symptoms of
Flogging Trolls
Authors: Chandy C. John
Journal: Annals of Internal Medicine (1994)

On Being a Doctor1 February 1994Flogging TrollsChandy C. John, MDChandy C. John, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-3-199402010-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I have sequestered myself in a small room, away from the usual distractions, so that I can sit down and write. I've wanted to write for many months, about many things, but I'm generally most inspired when I'm fatigued and disgusted, so I sleep instead. Not this time—this time I'll write.I'm doing a combined internal medicine and pediatrics residency and I'm in my third year now, but I took almost a year off last year to do an International Health Fellowship with the American Medical Student Association. I did a half-year of internal medicine as an intern and then ... Author, Article, and Disclosure InformationAuthors: Chandy C. John, MDCorresponding Author: Chandy C. John, MD, 3379 Autumn Lane, Ann Arbor, MI 48105. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Use of Pejorative Terms to Describe Patients: “Dirtball” Revisited 1 February 1994Volume 120, Issue 3Page: 242KeywordsGamesGlobal healthMedical dialysisPediatricsPerceptionPeritoneal dialysisPeritonitisResidencySleepTongue ePublished: 15 August 2000 Issue Published: 1 February 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Arteriovenous Communication of the Kidney in a Patient with Hypertension: Report of a Case in Which the Diagnosis was Suggested by Routine Pyelography
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acrokeratoelastoidosis
Authors: ALLAN S.HIGHET, ARTHUR ROOK, JANICE R. ANDERSON
Journal: British Journal of Dermatology (1982)

A case of acrokcratoelastoidosis (AKE) is reported. A review of the literature has established that at least three clinicopathotogical entities have been reported under this term. Two of the entities show a combination of hyperkcratosis with fragmentation of dermal elastic tissue, which justifies the designation AKE. The first, for which the term familial AKE is perhaps appropriate, though many cases have been sporadic, begins in childhood or early adult life, and there is no evidence that trauma or light exposure are factors in its production. The second is a more variable clinical syndrome occurring in middle or late adult life, and both physical trauma and light exposure appear to be concerned in its induction. The third syndrome to be reported under the designation AKE shows no abnormality of elastic tissue and appears to be a separate entity.
Extraction précoce des endoprothèses d’apposition métalliques dans la prise en charge de la nécrose de la paroi pancréatique: une étude prospective
Journal: Endoscopy (2018)

Dans cette étude collaborative américano-indienne prospective, les auteurs se sont intéressés aux résultats de la mise en place d’endoprothèse métallique couverte à rebords bilatéraux évasés (ou prothèse métallique bi-franges-MBF) pour la prise en charge des collections nécrotiques post-pancréatites aiguës, appelées communément WON pour “Wall-Off Necrosis”.
Danazol As First-Line Therapy for Myelodysplastic Syndromes
Authors: Perla Rocío Colunga-Pedraza, Alejandra Garza-Ledezma, Julia Colunga-Pedraza, Olga Cantu-Rodriguez, Rosa Elena Lozano-Morales, Guillermo Sotomayor Duque, Erika Cazares-Rendón, Erick J Rendón-Ramírez, Cesar Homero Gutierrez-Aguirre, Luz Tarin-Arzaga, David Gomez-Almaguer
Journal: Blood (2016)
Salmonella hadar Associated With Pet Ducklings— Connecticut, Maryland, and Pennsylvania, 1991
Journal: JAMA (1992)

The association between Salmonella and pets, particularly birds and reptiles, is well established (1-4). In the spring of 1991, a cluster of Salmonella infections in Connecticut, Maryland, and Pennsylvania was linked to pet ducklings. This outbreak underscores the need for careful handling of pets, especially ducklings during the spring and Easter seasons.
Workplace Exposure to Passive Smoking and Risk of Cardiovascular Disease: Summary of Epidemiologic Studies
Authors: Ichiro Kawachi, Graham A. Colditz
Journal: Environmental Health Perspectives (1999)

We reviewed the published epidemiologic studies addressing the relationship between workplace exposure to environmental tobacco smoke (ETS) and cardiovascular disease risk in three case-control studies and three cohort studies.Although the point estimates of risk for cardiovascular disease exceeded 1.0 in five of six studies, none of the relative risks was statistically significant because of the small number of cardiovascular end points occurring in individual studies.In common with most epidemiologic investigations of the health risks of ETS, none of the workplace studies included independent biochemical validation of ETS exposure.In contrast to the evidence on increased cardiovascular disease risk from exposure to spousal ETS, studies of ETS exposure in the workplace are still sparse and inconclusive.Conversely, there is no biologically plausible reason to believe that the hazards of ETS exposure that have been demonstrated in the home should not also apply to the workplace.
Cochlear Implants
Authors: George A. Gates, Richard T. Miyamoto
Journal: New England Journal of Medicine (2003)

Currently, a cochlear implant is the standard treatment for people whose hearing ability is so poor that well-fit hearing aids fail to permit effective oral communication. The implant is a neural stimulator whose electrode array is placed surgically in the lumen of the cochlea, near the auditory nerve. An external microphone picks up speech signals, and the signal processor transforms these signals into digital impulses that a radio-frequency carrier transmits percutaneously into the internal receiver–stimulator and electrode array (see Figure). The auditory cortex is stimulated by the implant, permitting the perception of the digitally processed information as speech.Cochlear implants . . .
CALIFORNIA AND CHRISTIAN SCIENTISTS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgery in muscular dystrophy
Authors: E. J. Eyring
Journal: JAMA (1972)

Properly timed surgical intervention can prolong the walking abilities of muscular dystrophy patients, as demonstrated by 17 patients who underwent 54 operative procedures. Awareness of pathokinesiology, insistence on immediate postoperative walking, and proper use of braces are essential for this approach. Reliance on parental care can reduce costs and improve results.
Fasting Serum Glucose Level and Cancer Risk in Korean Men and Women—Reply
Authors: Sun Ha Jee, Heechoul Ohrr, Jae Woong Sull, Ji Eun Yun, Ji Min, Jonathan M. Samet
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase Ib/II study of MEK162 (binimetinib [BINI]) in combination with imatinib in patients with advanced gastrointestinal stromal tumor (GIST).
Authors: Ping Chi, Li-Xuan Qin, Sandra P. D'Angelo, Mark Andrew Dickson, Mrinal M. Gounder, Mary Louise Keohan, Alexander Noor Shoushtari, Mercedes M. Condy, Theresa Konen, Alana Fruauff, Ronald P. DeMatteo, Samuel Singer, Sinchun Hwang, Cristina R. Antonescu, William D. Tap
Journal: Journal of Clinical Oncology (2015)

10507 Background: ETV1, a lineage-specific survival factor for GIST and its precursor interstitial cells of Cajal, represents a promising therapeutic target in GIST. In preclinical models, MEK inhibition with BINI, synergizes with imatinib in destabilizing ETV1 protein and suppressing GIST tumorigenesis and progression. Combined MEK and KIT inhibition therefore represents a novel therapeutic approach for patients with GIST. Methods: The phase Ib portion of the imatinib (400 mg daily) plus BINI was performed in patients (pts) with imatinib-resistant advanced GIST. A standard 3+3 dosing schema was utilized to determine the recommended phase II dose (RP2D) of this combination. Additional pts were enrolled on an expansion cohort at the RP2D. Responses were assessed by RECIST1.1 and Choi criteria every 8 weeks. Custom targeted next-generation sequencing with the Integrated Mutation Profiling of Actionable Cancer Targets (IMPACT) was performed on archived tumor samples for all pts. Results: Eighteen pts enrolled to the phase I portion, with 9 pts each in the dose escalation and the expansion cohorts. Median age 60 (range 30-74), 44% women, median prior therapy 3 (range 1-6, 14/18 pts had ≥ 3 prior therapies). Imatinib 400 mg daily with BINI 45mg BID was established as the RP2D. Dose limiting toxicity (DLT) was asymptomatic grade 4 Creatinine Phosphokinase (CPK) elevation (1/6 pts at RP2D). The most common non-DLT grade 3/4 toxicity was asymptomatic CPK elevation (12/18 pts). Other common Grade 2 toxicities include peripheral edema (5/18), rash (3/18). No unexpected toxicities observed. Of the 15 pts with evaluable CT scans, 5 pts (33%) had Choi PR; and 9 pts had RECIST SD at 8 weeks. Seven pts remain on trial at data cutoff (range 4-53 weeks). Median progression free survival is not reached. Correlation of outcome with IMPACT is forthcoming. Conclusions: BINI and imatinib combination is well-tolerated and has clinical activity in imatinib-refractory GIST. Phase II study is on-going in untreated GIST pts and a larger clinical trial in the imatinib-resistant GIST population is warranted. Clinical trial information: NCT01991379.
SERUM DIAGNOSIS OF SYPHILIS
Authors: J. J. Seelman
Journal: JAMA (1918)

<h3>To the Editor:</h3> —May I point out some fallacies in Dr. Noguchi's answer to my criticism of his proposed new method of performing the Wassermann test in Army and Navy laboratories? It is true that the presence of native antisheep amboceptors in human serum may cause errors in the Wassermann test when performed with a sheep hemolytic system. His statement, however, that this factor is uncontrollable is not correct. As a matter of fact I am quite certain that most careful workers who use the sheep hemolytic system remove the native antisheep amboceptors from serum before testing it. Dr. Noguchi frankly admits that with his method a moderately positive serum containing an excess of native complement may give a weaker reaction than would a serum with an average amount of complement. Then by what process of reasoning can he reach the conclusion that a weakly positive serum may not give
HEALTH OF THE MILITARY DEPARTMENT OF THE MISSOURI.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
International and interstate comparisons of homicide among young males
Authors: L. A. Fingerhut
Journal: JAMA (1990)

The homicide rate for males 15 through 24 years of age in the United States was compared with the rates in 21 other developed countries. The US homicide rate, 21.9 per 100 000, was more than four times higher than the next highest rate in Scotland (5.0). Most countries had rates that were between 1 and 3 per 100 000. The lowest rates were in Japan and Austria, each with rates below 0.6 per 100 000 males 15 through 24 years of age. Three quarters of the homicides in the United States resulted from the use of firearms contrasted with less than a quarter of all homicides in the comparison countries. The US homicide rate for black males 15 through 24 years of age (85.6) was more than seven times the rate for white males (11.2). In 1987 there were only four states that had homicide rates among white males that were as low as the rates among males in the comparison countries. The lowest state rate among young black males was still seven times the highest rate abroad. There are about 4000 homicides per year among young males in the United States. If the US homicide rate could be reduced to that in the country with the next highest rate, more than 3000 lives would be saved. (<i>JAMA</i>. 1990;263:3292-3295)
Mumps Orchitis
Authors: M Masarani, H Wazait, M Dinneen
Journal: Journal of the Royal Society of Medicine (2006)

Although the incidence of mumps orchitis has dramatically declined since the introduction of the childhood vaccination programme, a sharp increase in reported cases of both mumps and mumps orchitis has been seen recently in the UK. There are great concerns about mumps outbreaks and the associated risk of infertility; it remains an important clinical condition. Immunization is the best policy to avoid this viral disease.