tbuckley/cabot-search huggingface dataset:
POS1009 COMPARING OF DISEASE ACTIVITY, FUNCTION AND QUALITY OF LIFE IN PATIENTS FROM THE CLINICAL AND IMAGING ARM OF NONRADIOGRAPHIC AXIAL SPONDYLOARTHRITIS
Authors: S. Dimitrov, S. Hristova, S. Bogdanova-Petrova, T. Georgiev, T. Shivacheva
Journal: Annals of the Rheumatic Diseases (2022)

Background The concept of axial spondyloarthritis (axSpA) and non-radiographic axSpA (nr-axSpA), a subgroup of axSpA, has recently emerged. There are several studies proving the similar levels in disease activity and quality of life in patients with or without structural damage in spondyloarthritis. Objectives The aim of this study is to compare disease activity, functional status and quality of life in patients from the clinical and imaging arm of nonradiographic axial spondyloarthritis in Bulgaria. Methods A cross-sectional survey was conducted with rheumatologists and their consulting patients in Bulgaria from February 2012 through April 2019. Patients who had a rheumatologist confirmed diagnosis of nr-axSpA were eligible to participate. An information about patient demographics and symptoms duration were collected. Acute- phase reactants, patients’ reported data for disease activity (BASDAI), functional status (BASFI) and quality of life (ASQoL) were compared between the patients with or without MRI data for sacroiliitis. The level of significance was set to 0.05. Results A total of 98 patients from the imaging arm of nonradiographic arm and 62 patients from the clinical arm of nr-axSpA patients were included in this analysis. A higher proportion of patients from the imaging arm were male patients (51% vs 37%). The mean age was 33.8±7.71 in the imaging arm and 34.12±6.95 in the clinical arm (p&gt;0.05), with mean symptoms duration in both groups- respectively 0.76±0.26 and 0.48±0.13 years (p&gt;0.05). The mean value of C-reactive protein in the imaging arm was 14.81±28.59 and 7.05 ± 10.04, p=0.02 in both groups. The disease activity determined using patients reported data from BASDAI was 4.1±0.67 vs 4.01±0.78 (p&gt;0.05) and using ASDAS-CRP 2.31±0.87 vs 2.05±0.52 (p&gt;0.05) in the imaging and clinical arm. The evaluation of the function BASFI was 5.06±1.28vs 4.48±1.18, p&gt;0.05 in both groups of patients with nr-ax SpA. The QoL, determined by ASQoL revealed non statistical significant values between the groups – 4.79±3.27 and 5.18±3.03, p&gt;0.05. Conclusion Patients from the imaging and clinical arm of nr-axSpA share the same clinical features. The burden of the disease, as assessed by ASQoL measurement, is also similar in the investigated subgroups of Bulgarian nr-axSpA patients. References [1]Doward LC, Spoorenberg A, Cook SA et al. Development of the ASQoL: a quality of life instrument specific to ankylosing spondylitis. Ann Rheum Dis 2003;62:20-26. [2]Ivanova, M., Dimitrov, S., Hristova, S., Dimitrov, A., Kadinov, V. and Stoilov, R. 2018. COMPARATIVE CHARACTERISTICS OF PATIENTS WITH NON-RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS AND ANKYLOSING SPONDYLITIS. Rheumatology (Bulgaria ). 26, 3 (Sep. 2018), 3-10. Disclosure of Interests None declared
AB1531-HPR ECOLOGICAL MOMENTARY ASSESSMENT OF THE SYMPTOMS IN SJÖGREN’S SYNDROME: DEVELOPMENT AND VALIDATION OF A DEDICATED WebApp
Authors: G. Laurie, S. Berrouiguet, A. A. Benyoussef, D. Guellec, G. Carvajal, T. Marhadour, S. Jousse-Joulin, B. Cochener-Lamard, M. Labetoulle, J. E. Gottenberg, T. Bourcier, A. Saraux, M. Consigny, M. Gravey, V. Devauchelle-Pensec, R. Seror, D. Cornec
Journal: Annals of the Rheumatic Diseases (2022)

Background Primary Sjögren’s syndrome (pSS) is a rare systemic autoimmune disease with no specific treatment at present. To better assess patient symptoms, we have developed a web application (WebApp) to collect patient symptom intensity on a regular basis. Objectives To measure the daily variability of symptoms using the WebApp. We also evaluated its ease of use. Methods 45 consecutive patients with pSS were included in 3 referral centers. Symptoms were assessed during the baseline and 3 month visits. We collected the VAS relating to fatigue, dryness and pain as well as the ESSPRI score. Patients used the WebApp daily for 3 months. The variability of symptoms over time was assessed by the predicted median error. This value was determined using a linear regression model, in order to predict the value at the 3rd month, then this value was compared to the actual value collected at the 3rd month during the clinical visit. The ease of use of the WebApp was assessed using a satisfaction score (SUS score). Results Of the 45 patients included, 91.1% were women with an average age of 57 years, and low systemic disease activity (84.4% had an ESSDAI score below 5). The intensity of the symptoms collected during the clinical visits was similar at baseline and at 3 months. The values ​​of the median error for each measurement are between 0.5 and 0.8. The 3-month predicted median error values ​​ranged from 2 to -3. The patients all used the web application for 3 months with good attendance (80% of data completion) and were satisfied with this tool (median SUS score = 90). Conclusion Symptoms of pSS fluctuate from day to day in the majority of patients, making a point measurement imprecise. The developed WebApp is easy to use, and could allow more sensitive detection of the effect of a therapeutic intervention. This tool will soon be evaluated during prospective interventional clinical trials. Acknowledgements I would like to thanks all people who have helped and were directly or indirectly involved in this study. Disclosure of Interests None declared
AB0971 Relationship between walking speed and lower limb skeletal muscle mass in patients with knee joint disorders.
Authors: K. Inui, K. Mandai, S. Maeda, S. Masuda, S. Yamada, H. Ohashi, T. Ikawa
Journal: Annals of the Rheumatic Diseases (2022)

Background Knee joint disorder is one of the factors causing frailty in the elderly, which is associated with a decrease in walking speed. Objectives We measured the walking speed of patients scheduled to undergo primary total knee arthroplasty (TKA) and examined factors correlated with walking speed. Methods The patients with knee disorders scheduled to undergo knee arthroplasty at our hospital between July 2020 and May 2021 were included. They were assessed for basic attributes, clinical assessment including Kness Society Score (KSS), degree of pain on walking by visual analogue scale (VAS), range of motion (ROM), and also leg skeletal muscle mass index (SMI; whole-body mode DXA), quadriceps strength by dynamometer with written consent (UMIN ID: 000040940). And Japanese Cardiovascular Health Study criteria for frailty, and sarcopenia by Asian Working Group for Sarcopenia 2019 criteria were evaluated. Results Demographic data of 83 patients (65 women, mean age 74.9 years) included in this study was shown in Table 1. The distribution in frailty is 36.2% and that in sarcopenia is 7.3%. Most of the patients with frailty with knee disorder did not suffer from sarcopenia. A multivariate analysis was conducted with walking speed as the objective variable and the dependent variables as age, gender, pain VAS on walking, KSS, leg SMI, quadriceps strength, and ROM. The results showed that age and ROM in flexion were significantly and independently associated with walking speed (P=0.01, 0.03). Gender, pain VAS on walking, KSS, leg SMI, quadriceps strength, and ROM in extension were not significantly associated with walking speed (P=0.92, 0.11, 0.11, 0.52, 0.85, 0.52). Conclusion Among the patients with knee disorders immediately before arthroplasty, frailty was not caused by sarcopenia. Age was found to be the most correlated factor with walking speed, and walking speed became slower with age. In addition, poor flexion angle was also the factor for delayed walking speed, but it did not correlate with lower limb skeletal muscle mass or quadriceps strength. In this study pain on walking was not significant factor for walking speed, because it was observed in most of all cases. Factor Group disease (n) osteoarthritis 78 (94%) rheumatoid arthritis 5 (6.0%) body mass index (kg/m 2 ) 25.54 (4.11) pain VAS on walking 37.08 (26.35) total Knee Society Score 77.66 (27.85) range of motion (degree) flexion 119.46 (12.88) extension -9.58 (6.59) quadriceps power (N) 122.00 [53.00, 350.00] waling speed (m/sec) 0.95 (0.33) grip power (kg) 20.24 (6.97) skeletal muscle mass index (kg/m 2 ) appendicular 6.50 [4.92, 9.85] lower limb 5.06 [3.76, 7.56] Frailty (n) none 10 (12.5%) Pre-frail 41 (51.2%) frail 29 (36.2%) Sarcopenia (n) none 76 (92.7%) sarcopenia 4 (4.9%) severe sarcopenia 2 (2.4%) mean (standard deviation) ; median [min max] Disclosure of Interests None declared
AB0964 Psoriatic arthritis (PsA) with positive rheumatoid factor (RF) versus psoriatic arthritis with negative RF
Authors: S. Ghazzali, I. EL Harch, N. Akasbi, I. El Mezouar, T. Harzy
Journal: Annals of the Rheumatic Diseases (2022)

Background Rheumatoid factor (RF) has been detected in several patients with psoriatic arthritis (PS). It is likely that its positivity is linked to a very specific clinical, biological and/or evolutionary profile of PsA. Objectives The objective of our study was to evaluate the frequency of positive rheumatoid factor during PsA, and to define the characteristics and factors related to this positivity. Methods Monocentric observational cross-sectional study including 84 patients with PsA, fulfilling the CASPAR criteria, and hospitalized in our rheumatology department in University Hospital Hassan II of Fez, on the period lying between January 2012 and October 2021. A threshold greater than 20Ui/ml of defines RF positivity. Results Our study included 84 patients, the average age was 57 +/- 13 years. The sex ratio was 0.35 M/F, the average duration of disease progression was 6 years +/- 8 years. 47.6% of patients had a positive RF (40 patients) while 52.4% of patients had a negative RF (44 patients). In bivariate analysis, PsA with positive RF had an earlier age of the disease onset (p=0.017), was more frequent in chronic smokers (p=0.045), and showed more enthesis damage (p=0.046). Also, patients with PsA and a positive RF had a higher biological inflammatory syndrome (p=0.013) in particular CRP (p=0.007), higher Basdai and DAPSA (p=0.021) (p=0.021) respectively In multivariate analysis, enthesis damage involvement was significantly linked to RF positivity (p=0.039, OR=3, IC=1.059-8.495), as was the biological inflammatory syndrome (p=0.010, OR=3.875, IC=1.382 -10.766). Conclusion In our study, PsA with positive RF is found to be earlier and more severe in comparison with PsA with negative RF, and more frequently adopts the peripheral enthesitic form. References [1]L Y Dai1,D D Gong2,J X Zhao1 [Clinical characteristics of psoriatic arthritis with positive rheumatoid factor or anti-cyclic citrullinated peptide antibody] Disclosure of Interests None declared
POS1292 ULTRASONOGRAPHIC GUIDED INTRA ARTICULAR STEROID AND HYALURONIC ACID IN ADHESIVE CAPSULITIS WITH AND WITHOUT SUPRASCAPULAR NERVE BLOCK
Authors: E. Mohamed, A. Metwaly, A. Moshrif, M. Elwan
Journal: Annals of the Rheumatic Diseases (2022)

Background Adhesive capsulitis (AC), often known as frozen shoulder, is a common musculoskeletal condition characterised by shoulder pain and reduced active and passive mobility. Intra-articular injections is an effective treatment option and provide faster pain relief in patients with AC Objectives Compare the effictiveness of intra articular injection (IAI) of steroid and HA with or without Suprascapular nerve block (SSNB) in the management of AC. Methods Randomized control trial involved 80 patients (62 women and 18 men) clinically diagnosed as having adhesive capsulitis divided into 2 main groups; intra articular injection with SSNB (40 cases) and without SSNB (40 cases), each group divided into 2 subgroups; Twenty patients were treated with ultrasound guided intra articular injection of steroid (4ml of 2% lidocaine and 2 ml of 40 mg/ml triamcinolone) and another twenty patients were treated with ultrasound guided intra articular injection of hyaluronic acid (4 ml of 2% lidocaine and 2 ml hyaluronic acid). Results Intra articular shoulder injection with SSNB has higher significant visual analogue scale (VAS) score at baseline and lower significant VAS score at 1st and 3rd week (p &lt; 0.001). However, there was no significance between both groups regarding disability score at 3rd weak (p=0.316). In contrast, there was a high significance between them considering disability score at baseline, 1st, 6th weak (p&lt;0.001 and 0.008, respectively). Conclusion In patients with adhesive capsulitis, both a combination an IAI alone or with SSNB dramatically improved pain and functional results. The use of an SSNB in conjunction with an IAI especially with steroid enhanced therapeutic effectiveness. References [1]D’Orsi GM, Via AG, Frizziero A, Oliva F. Treatment of adhesive capsulitis: a review. MLTJ. 2012; 2(2):70-78. [2]Kingston K, Curry EJ, Galvin JW, Li X. Shoulder adhesive capsulitis: epidemiology and predictors of surgery. J Shoulder Elbow Surg. 2018 Aug;27(8):1437-1443. [3]Zreik NH, Malik RA and Charalambous CP. Adhesive capsulitis of the shoulder and diabetes:a meta-analysis of prevalence. MLTJ. 2016;6 (1):26-34. [4]Rangan A, Hanchard N, McDaid C. What is the most effective treatment for frozen shoulder? BMJ 2016;354:i4162. Disclosure of Interests None declared
AB0960 Ultrasonographic assessment of distal interphalangeal joints in psoriatic arthritis
Authors: I. Mahmoud, S. Rahmouni, A. Ben Tekaya, S. Bouden, L. Rouached, R. Tekaya, O. Saidane, L. Abdelmoula
Journal: Annals of the Rheumatic Diseases (2022)

Background Distal interphalangeal (DIP) joint involvement is frequent in Psoriatic arthritis (PsA). Ultraousnd (US) may help identify subclinal DIP arthritis. Objectives We aimed to assess by US the DIP joint involvement in PsA in comparison with healthy controls (HC). Methods This was a cross-sectional study including 33 PsA patients and 21 matched-healthy controls (HC). An US scan of all DIP joints was performed in order to look for erosions, synovitis (B-mode and doppler) and extensor tendon enthesopathy. Results We included 33 patients with PsA and 21 HC. There was no difference between the two groups regarding the age (51.2 ±12.5 vs 53±11.8 years, p=0.5), sex-ratio (0.65 vs 0.61, p=1), manual activity (p=1) and smoking status (23.8% vs 18%, p=0.433).On clinical examination,we did not find any tender nor swollen DIP joints in both groups. Eleven PsA patients (34 %) had psoriatic onychopathy (45 fingernails) with a mean NAPSI 7 (IQR (25,75)) [2 -18]. In the PsA group, a total of 323 DIP joints were examined by US, synovitis of the DIP joints was detected in ten DIP joints (3.1%)(right hand: seven, left hand:three), six of them had PD (right hand:four, left hand:two). Eosions were found in 16 DIP joints (4.95%) (right hand:seven, left hand: nine). Enthesophytes were seen in 82 DIP joints (25,2%). At patient level, six PsA patients had at least one US synovitis (18.1%), seven had at least one erosion (21.2%) and 22 had at least one DIP joint with enthesophytes (66.6%) Compared to HC, PsA patients had more synovitis (3.1% vs 0, p=0.001),more erosions (4.95% vs 0.4%, p=0,03), and more enthesophytes (25.2% vs, 17%, p=0,002) The was no difference between the two groups regarding the thickness of the extensor tendon (0.63 mm vs 0.61 mm, p=0.594). In the PsA group, the patients with nail dystrophy had more osteophytes (24% vs 10%, p&lt;0,001), more erosions (14.6% vs 1.96%, p=0.000), and more synovitis (6%, vs 1.9%, p=0.037). Conclusion Subclinical involvement of DIP joints is common in PsA patients, notably in the presence of nail dystrophy. Disclosure of Interests None declared
POS0722 CLONAL HEMATOPOIESIS OF INDETERMINATE POTENTIAL AND ACCELERATED ATHEROSCLEROSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS (HEMATOPLUS STUDY)
Authors: C. David, N. Costedoat-Chalumeau, N. Duployez, D. Belhadi, V. Leguern, P. Eloy, C. Preudhomme, J. Chezel, N. Morel, A. Mathian, Z. Amoura, T. Papo, K. Sacre
Journal: Annals of the Rheumatic Diseases (2022)

Background The detection of somatic mutations in genes of myeloid cells in asymptomatic patients - defining clonal hematopoiesis of indeterminate potential (CHIP) - predisposes to cardiovascular events (CVE) in the general population. Objectives We aimed to determine whether CHIP was associated with CVE in SLE patients. Methods The study is an ancillary study of the randomized, double-blind, placebo-controlled, multicenter trial PLUS study conducted from June 2007 through August 2010 at 37 centers in France involving 573 SLE patients. The search for somatic mutations by high-throughput sequencing of 53 genes involved in clonal hematopoiesis was performed on genomic DNA collected at PLUS inclusion. The CHIP prevalence was assessed in SLE and in a retrospective cohort of 479 patients free of hematological malignancy. The primary outcome was the incident CVE in SLE. Results Screening for CHIP was performed in 438 SLE patients (38 [29-47] years, 91·8% female). Overall, 63 somatic mutations were identified in 47 patients defining a CHIP prevalence of 10·7% in SLE. Most SLE patients (78·7%) carried a single mutation. Most variants (62·5%) were located in the DNMT3A gene. CHIP was associated with age, age at SLE diagnosis and a lower frequency of antiphospholipid antibodies. CHIP occurred more than 20-years earlier (p&lt;0·00001) in SLE than in controls. The detection of CHIP at inclusion was not associated with the occurrence of CVE during follow up (HR= 0·42 (0·06 – 3·21), p=0·406). Conclusion The prevalence of CHIP is high in SLE with respect to age but was not associated with incident CVE. Disclosure of Interests None declared
AB1285 BEHCET’S DISEASE IN RUSSIAN FEDERATION: GENDER RELATED CLINICAL FEATURES
Authors: T. Lisitsyna, Z. Alekberova, G. Davidova, T. Reshetnyak, E. Nasonov
Journal: Annals of the Rheumatic Diseases (2022)

Background In Behcet’s Disease (BD) some major organs are more involved in men and have worse outcomes. Gender related clinical features of BD are different in various countries. Objectives to describe the gender related clinical features of Russian Federation’s cohort of BD patient’s. Methods This single center cohort study was carried out at the V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia from 1990 to 2021. 560 of BD patients (351 men (62,7%) and 209 (37,3%) women were consecutively enrolled in the study. All the patients met the ICBD (2014). The activity of the disease was determined using a Behcet’s Disease Current Activity Form (BDCAF). Clinical features of the BD were compared according to the patient’s gender. Results Female to male ratio was 1,0: 1,7. The majority of patients were natives of the North and South Caucasus (66,0%) and ethnic Russians (21,6%). Mean (M±SD) age of male and female did not differed at the study inclusion (32,4±9,65 vs 33,8±10,5 years) and at disease onset (22,1±9,67 vs 22,6±10,8 years). The most frequent clinical manifestations were oral and genital aphthosis, skin, ocular and joints involvements. Men had higher BD-activity score (BDCAF) (p&lt;0,001), prevalence of skin (91,1% vs 79,4%, OR=1,57, 95% CI=0,95-2,58, p&lt;0,001), ocular (68,4% vs 48,8%, OR=1,38, 95% CI=0,96-1,96, p&lt;0,001), vascular (venous and arterial thrombosis) involvement (21,4% vs 11,5%, OR=1,26, 95% CI=0,77-2,07, p=0,002), pathergy test (33,3% vs 22,9%, OR=1,19, 95% CI=0,80-1,77, p=0,004) and HLA-B51 (65,0% vs 40,6%, OR=1,53, 95% CI=1,02-2,29, p&lt;0,001) positivity. Male and female did not differ in prevalence of oral and genital aphthosis, joint, neurological, gastrointestinal manifestations (Table 1). Table 1. BD manifestations in the Russian Federation depending on gender Characteristics, М±SD; n (%) Male, n=351 Female, n=209 p Mean age, yrs 32,4±9,65 33,8±10,5 n/s Mean age at disease onset, yrs 22,1±9,67 22,6±10,8 n/s BDCAF, point 7,43±2,23 6,62±2,11 &lt;0,001 Oral aphthosis 338 (96,3%) 204 (97,6%) n/s Genital ulcers 245 (69,8%) 146 (69,8%) n/s Ocular involvement 240 (68,4%) 102 (48,8%) &lt;0,001 Skin involvement 320 (91,1%) 166 (79,4%) &lt;0,001 Positive pathergy test 117 (33,3%) 48 (22,9%) 0,005 Gastro-intestinal involvement 67 (19,1%) 37 (17,7%) n/s Neurological involvement 52 (14,8%) 21 (10,0%) n/s Vascular involvement 75 (21,4%) 24 (11,5%) 0,002 Joints involvement 230 (65,5%) 137 (65,6%) n/s HLA-B5(51) positivity 158 from 243 (65,0%) 71 from 175 (40,6%) &lt;0,001 Conclusion Russian Federation’s cohort of BD patients did not differ in clinical characteristics from other world regions. Ocular, skin, vascular lesions, positive pathergy test and HLA-B51 positivity are more frequent in men than in women. Disclosure of Interests None declared
AB1369 DISCO-VERTEBRAL BIOPSY VERSUS INDIRECT DIAGNOSTIC TOOLS IN BRUCELLAR SPONDYLODISCITIS
Authors: S. Rekik, S. Boussaid, H. Tbini, S. Jemmali, S. Rahmouni, K. Zouaoui, H. Sahli, M. Elleuch
Journal: Annals of the Rheumatic Diseases (2022)

Background The diagnosis of brucellar spondylodiscitis can be made by serological examinations or by isolating the germ on disco-vertebral biopsy (DVB). Objectives We aimed to study the interest of DVB and other less invasive diagnostic tools in brucellar spondylodiscitis. Methods A retrospective study over a period of 15 years, including 18 patients diagnosed with brucellar spondylodiscitis. Results Eighteen cases were collected (13 men and 5 woman). Nine patients had a DVB. In all cases, microbiological study did not reveal the causative agent (Brucella). A case of superinfection with Staphylococus Xylosus was noted. Histopathological examination was performed in eight patients. It showed osteitis and chronic spondylodiscitis lesions in 4 cases, a non-specific inflammatory infiltrate in 3 cases, and a progressive infectious spondylitis in one case. Wright’s serodiagnosis and the rose bengal test were positive in 7 out of 8 cases performed. As for the diagnosis by indirect immunofluorescence made in 6 cases, it was positive in 5 cases. For the other nine cases who did not undergo DVB, Wright’s serodiagnosis and rose bengal test were positive in 9 and 6 patients respectively, indirect immunofluorescence made in 5 patients was positive in 4 cases. Conclusion Serological examinations in brucellar spondylodiscitis seem more profitable and less invasive than DVB. Other studies with a larger population seem to be necessary to compare the different methods and complete this preliminary study. Disclosure of Interests None declared