AB0686 THE NEUTROPHIL-TO-C3 RATIO (NC3R) WAS AN INFLAMMATORY MARKER IN THE ASSESSMENT OF LUPUS NEPHRITIS AND OCULAR VESSEL DENSITY IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS
Authors: M. Maitiyaer, P. Li, H. Li, X. Yang, C. Chen, J. Zhang, W. Huang, Z. Liu, S. L. Yu
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE). An increased neutrophil to C3 ratio (NC3R) may reflect LN. NC3R is a promising predictor of LN and ocular involvement in SLE patients. <h3>Objectives</h3> To explore the relationship between NC3R and LN patients and ocular vessel density in SLE patients. <h3>Methods</h3> This retrospective study included 53 patients with LN and 80 SLE patients without kidney involvement. The differences in NC3R between patients with and without LN were evaluated. Correlations between NC3R and other variables in SLE patients were assessed. Receiver operating characteristic curves (ROC) was constructed in NC3R to predict LN. Multivariate logistic regression analysis was used to analyze the independent factor of LN. We also investigate the role of NC3R in ocular involvement in SLE patients. <h3>Results</h3> NC3R was increased significantly in the LN group as compared with those SLE patients without LN(7.7 vs 4.5, P=0.002). NC3R were positively correlated with 24-hour proteinuria (r=0.437, P&lt;0.001), and SLEDAI score(r=0.389, P&lt;0.001), and negatively correlated with C3(r=-0.346, P&lt;0.001) and C4(r=-0.293, P=0.001). Multiple regression analysis suggested that NC3R was an independent risk factor of LN[OR: 4.41 (1.64~11.91), P=0.003]. NC3R [AUC: 0.642, 95%CI(0.540~0.744)] was useful in differentiating LN patients, and the optimal cutoff was 4.56 (sensitivity: 79.6%, specificity: 49.2%). In the high NC3R group patients, there was increased superficial vessel density. <h3>Conclusion</h3> NC3R was a plausible indicator to predict LN and ocular involvement. Therefore, evaluating NC3R before treatment could help clinicians to identify potential organ involvement in patients with SLE. <h3>References</h3> [1]Kiriakidou M, Ching CL. Systemic Lupus Erythematosus. <i>Ann Intern Med.</i> 2020;172(11):ITC81-ITC96. [2]Fanouriakis A, Tziolos N, Bertsias G, Boumpas DT. Update omicronn the diagnosis and management of systemic lupus erythematosus. <i>Ann Rheum Dis.</i> 2021;80(1):14-25. [3]Almaani S, Meara A, Rovin BH. Update on Lupus Nephritis. <i>Clin J Am Soc Nephrol.</i> 2017;12(5):825-835. [4]Lubon W, Lubon M, Kotyla P, Mrukwa-Kominek E. Understanding Ocular Findings and Manifestations of Systemic Lupus Erythematosus: Update Review of the Literature. <i>Int J Mol Sci.</i> 2022;23(20). [5]Silpa-archa S, Lee JJ, Foster CS. Ocular manifestations in systemic lupus erythematosus. <i>Br J Ophthalmol.</i> 2016;100(1):135-141. [6]Banchereau R, Hong S, Cantarel B, et al. Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients. <i>Cell.</i> 2016;165(3):551-565. [7]Mohan C, Putterman C. Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis. <i>Nature reviews Nephrology.</i> 2015;11(6):329-341. [8]Kaplan MJ. Neutrophils in the pathogenesis and manifestations of SLE. <i>Nature Reviews Rheumatology.</i> 2011;7(12):691-699. [9]Tang D, Tang Q, Zhang L, Wang H. High Neutrophil-lymphocyte Ratio Predicts Serious Renal Insufficiency in Patients with Lupus Nephritis. <i>Iran J Immunol.</i> 2022;19(1):5. [10]Firizal AS, Sugianli AK, Hamijoyo L. Cut off point of neutrophil-to-lymphocyte ratio as a marker of active disease in systemic lupus erythematosus. <i>Lupus.</i> 2020;29(12):1566-1570. [11]Liu P, Li P, Peng Z, et al. Predictive value of the neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-neutrophil ratio, and neutrophil-to-monocyte ratio in lupus nephritis. <i>Lupus.</i> 2020;29(9):1031-1039. [12]Yu J, Zeng T, Wu Y, et al. Neutrophil-to-C3 ratio and neutrophil-to-lymphocyte ratio were associated with disease activity in patients with systemic lupus erythematosus. <i>J Clin Lab Anal.</i> 2019;33(1):e22633. [13]Conigliaro P, Cesareo M, Chimenti MS, et al. Evaluation of retinal microvascular density in patients affected by systemic lupus erythematosus: an optical coherence tomography angiography study. <i>Ann Rheum Dis.</i> 2019;78(2):287-289. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.