tbuckley/cabot-search huggingface dataset:
Focal adhesion kinase is expressed in acantholytic keratinocytes associated with pemphigus vulgaris and pemphigus foliaceus
Authors: N.S. PENNEYS
Journal: British Journal of Dermatology (1996)

Summary Focal adhesion kinase is a protein-tyrosine kinase that is found in cellular contact sites and is phosphorylated in response to cell attachment. It is possible that the immunohistochemical detection of this enzyme might be increased in keratinocytes involved in an acantholytic process. Normal skin, pemphigus vulgaris and foliaceus, Darier's disease, Hailey-Hailey disease, warty dyskeratoma. Grover's disease and spongiotic dermatitis were assayed for the immunohistochemical expression of focal adhesion kinase. Focal adhesion kinase was not observed in normal epidermis. This antigen was observed in keratinocytes adjacent to acantholytic spaces and in acantholytic cells in pemphigus vulgaris and foliaceus. Focal adhesion kinase was not detected in keratinocytes involved in focal acantholytic dyskeratoses such as Darier's disease, Grover's disease and warty dyskeratoma but was weakly detected in Hailey-Hailey disease. One consequence of immunologically mediated acantholysis is the upregulation of focal adhesion kinase, possibly as a component of biochemical pathways that reconstruct the process of adhesion or respond to the process of acantholysis.
Cross-Cultural Issues and<i>Treatments of Psychiatric Disorders</i>
Authors: IAN CANINO, JAMES C.-Y. CHOU, JUNE JACKSON CHRISTMAS, PETER CHU, HORACIO FABREGA, BLANCA FERNANDEZ-POL, DAVID C. FOOS, EZRA E.H. GRIFFITH, PHYLLIS HARRISON-ROSS, BILLY E. JONES, MARVIN KARNO, KEH-MING LIN, LUIS R. MARCOS, CERVANDO MARTINEZ, MARIO I. RENDON, PEDRO RUIZ, JAMES W. THOMPSON, MANUEL TRUJILLO, EDUARDO R. VAL, ROGER DALE WALKER, JOE YAMAMOTO
Journal: American Journal of Psychiatry (1991)
Partial Recovery From Renal Failure Following Methoxyflurane Anesthesia
Authors: Roland D. Paegle
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Halpren et al in their recent article "Interstitial Fibrosis and Chronic Renal Failure Following Methoxyflurane Anesthesia" (223:1239, 1973) presented two cases. They reviewed the literature and argued that the progressive interstitial fibrosis, which they had noted in one patient, was due to fluoride, a metabolite<sup>1</sup>of methoxyflurane (Penthrane). We report two additional cases of chronic renal failure following methoxyflurane anesthesia, one of which recovered sufficiently in five weeks to be discharged. In the other patient renal failure began only after a second, higher dose of the anesthetic. This may indicate a dose-dependent rather than a hypersensitivity reaction. Phagocytosis of the intratubular crystalline oxalate deposits by foreign-body giant cells in one case could represent a defense mechanism that might lead to improvement of renal function. <h3>Report of Cases.—Case 1.—</h3> A 77-year-old woman received methoxyflurane and nitrous oxide for two hours and fifteen minutes during choledocholithotomy.
Australia antigen and hepatitis
Authors: B. S. Blumberg
Journal: JAMA (1969)

In 1965, we reported a "new" antigen, Australia antigen, in the serum of patients with leukemia.<sup>1</sup>Research since then has dealt with the epidemiology, genetics, and physical and chemical characteristics of the antigen,<sup>2</sup>Early in the investigation<sup>3</sup>it became clear that Australia antigen is closely associated with, or may itself be, a causal agent of viral hepatitis.<sup>26</sup>It is estimated that tens of millions of asymptomatic people carry the antigen chronically.<sup>1,2</sup>These deductions have resulted from a systematic study of antigens in human blood with use of sera from multiply transfused patients as sources of antibody. In 1961 Allison and Blumberg hypothesized that individuals receiving multiple transfusions would receive some serum proteins of a phenotype different from their own and would respond by producing antibodies. It was appreciated that both inherited and acquired antigens might occur in human serum and cause antibody formation in blood
Modern Clinical Psychiatry
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Establishment of a Cell Line From an Inbred Mouse Strain for Viral Transformation Studies: Simian Virus 40 Transformation and Tumor Production
Authors: Takemoto, K. K., Ting, R. C. Y., Ozer, H. L., Fabisch, P.
Journal: JNCI Journal of the National Cancer Institute (1968)

Journal Article Establishment of a Cell Line From an Inbred Mouse Strain for Viral Transformation Studies: Simian Virus 40 Transformation and Tumor Production Get access K. K. Takemoto, K. K. Takemoto Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases,3Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar R. C. Y. Ting, R. C. Y. Ting Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases,3Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar H. L. Ozer, H. L. Ozer Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases,3Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar P. Fabisch P. Fabisch Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases,3Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 41, Issue 6, December 1968, Pages 1401–1409, https://doi.org/10.1093/jnci/41.6.1401 Published: 01 December 1968 Article history Received: 26 July 1968 Accepted: 25 September 1968 Published: 01 December 1968
Landmark perspective: Roentgenography of the urinary tract
Authors: J. A. Evans
Journal: JAMA (1983)

The article by Osborne and colleagues entitled "Roentgenography of Urinary Tract During Excretions of Sodium Iodid" that appeared inThe JournalFeb 10, 1923, is medically of considerable historical importance in that it was the first attempt to provide a simple, safe, practical intravenous (IV) method of visualizing the kidneys, ureters, and bladder. Visualization of these structures by retrograde ureteral catheterization had been achieved some years earlier in 1906 by Voelcker and von Lichtenberg.<sup>1</sup>However, instrumentation was required — not invariably successful, even as today — and the contrast media used at that time were irritating and even toxic if absorbed. Therefore, retrograde pyelography, despite its limitations, was the only means of demonstrating renal anatomy and, at this time, was only partially successful. An IV method or, even better, an oral method of roentgenographically visualizing the upper urinary tract would be a great contribution to the diagnosis and treatment
Central vasopressin in experimental aortic stenosis in the rat
Authors: F. Muders, E. P Kromer, U. Bahner, D. Elsner, B. Ackermann, H. Schunkert, M. Palkovits, G. A. Riegger
Journal: Cardiovascular Research (1995)

Journal Article Central vasopressin in experimental aortic stenosis in the rat Get access Frank Muders, Frank Muders * aKlinik und Poliklinik für Innere Medizin II, University of Regensberg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany *Correspondence to Dr Muders. Search for other works by this author on: Oxford Academic PubMed Google Scholar Eckhard P Kromer, Eckhard P Kromer aKlinik und Poliklinik für Innere Medizin II, University of Regensberg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Udo Bahner, Udo Bahner bMedizinische Klinik, University of Würzburg, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Dietmar Elsner, Dietmar Elsner aKlinik und Poliklinik für Innere Medizin II, University of Regensberg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Bettina Ackermann, Bettina Ackermann aKlinik und Poliklinik für Innere Medizin II, University of Regensberg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Heribert Schunkert, Heribert Schunkert aKlinik und Poliklinik für Innere Medizin II, University of Regensberg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Miklos Palkovits, Miklos Palkovits cLaboratory of Cell Biology, National Institute of Mental Health, Bethesda, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Günter AJ Riegger Günter AJ Riegger aKlinik und Poliklinik für Innere Medizin II, University of Regensberg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 29, Issue 3, March 1995, Pages 416–421, https://doi.org/10.1016/S0008-6363(96)88600-7 Published: 01 March 1995 Article history Received: 26 May 1994 Accepted: 24 October 1994 Published: 01 March 1995
From the Centers for Disease Control and Prevention. Transmission of hepatitis C virus infection associated with home infusion therapy for hemophilia
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Are Physicians Advising Smokers to Quit?
Authors: Robert F. Anda
Journal: JAMA (1987)

Physicians can play an important role in smoking cessation because they have frequent contact with smokers and because most smokers believe that a physician's advice is important in the decision to quit. Therefore, to determine smokers' perceptions of physician involvement in smoking cessation, we analyzed aggregate data from two random statewide surveys of 5875 Michigan adults. Of smokers who had seen a physician in the previous year, only 44% reported that they had ever been told to quit smoking by a physician. Young male smokers were the least likely (30%) to have been told to quit. Smokers who were hypertensive, obese, diabetic, sedentary, or users of oral contraceptives were no more likely to have been told to quit than smokers without these additional cardiovascular risks. Conversely, smokers who had survived a myocardial infarction or stroke were more likely to have been told to quit than smokers who had not suffered these events (73% vs 43%). Most smokers do not perceive physicians to be even minimally involved in their efforts to quit. Physicians need to increase their efforts in counseling smokers to quit before smoking-related diseases result, especially for smokers with additional risk factors for cardiovascular disease. (<i>JAMA</i>1987;257:1916-1919)
Illegal drugs and periodontal conditions
Authors: Alessandro Quaranta, Orlando D'Isidoro, Adriano Piattelli, Wang Lai Hui, Vittoria Perrotti
Journal: Periodontology 2000 (2022)

Abstract In recent years, the practice of dentistry and periodontology has become complicated by several risk factors, including the treatment of an increasing number of patients with substance use disorder. This review presents an update in the current literature of the impact of illegal drug use on periodontal conditions and their possible effect as risk factors or indicators. The main illegal drugs that may have an impact on periodontal health and conditions are described, including their effect, medical manifestations, risks, and the overall effect on oral health and on the periodontium. Where available, data from epidemiologic studies are analyzed and summarized. The clinical management of periodontal patients using illegal drugs is reported in a comprehensive approach inclusive of the detection of illicit drug users, screening, interviewing and counseling, the referral to treatment, and the dental and periodontal management. With regard to the impact of illegal substance use on periodontal conditions, there is moderate evidence that regular long‐term use of cannabis is a risk factor for periodontal disease, manifesting as a loss of periodontal attachment, deep pockets, recessions, and gingival enlargements. Limited evidence also shows that the use of cocaine can cause a series of gingival conditions that mostly presents as chemical induced‐traumatic lesions (application of cocaine on the gingiva) or necrotizing ulcerative lesions. There is a scarcity of data regarding the impact of other drug use on periodontal health. There is evidence to suggest that regular long‐term use of cannabis is a risk factor for periodontal disease and that the use of cocaine can cause a series of periodontal conditions. The dental treatment of subjects that use illegal substances is becoming more common in the daily clinical practice of periodontists and other dental clinicians. When the clinicians encounter such patients, it is essential to manage their addiction properly taking into consideration the impact of it on comprehensive dental treatment. Further studies and clinical observations are required to obtain sound and definitive information.
Nitric Oxide and Septic Shock
Authors: J. Perren Cobb
Journal: JAMA (1996)

<h3>CASE REPORTS</h3><h3>Case 1</h3> A 23-year-old woman presented with a 2-week history of bruising and fever. She was diagnosed as having acute myelogenous leukemia. Three days after beginning chemotherapy, she became disoriented and hypotensive. Her platelet count was 60×10<sup>9</sup>/L, and her white blood cell count was 1.0×10<sup>9</sup>/L, with an absolute neutrophil count of 0.48×10<sup>9</sup>/L. She was resuscitated with 3 L of saline and she was given dopamine at 5 μg·kg<sup>-1</sup>·min<sup>-1</sup>and broad-spectrum antibiotics. Her chest radiograph revealed diffuse interstitial-alveolar infiltrates. She required mechanical ventilation for progressive hypoxemia. Pulmonary and radial arterial catheters were inserted and the following hemodynamic parameters were obtained: blood pressure, 90/35 mm Hg; mean arterial pressure (MAP), 53 mm Hg; heart rate, 124 beats per minute; cardiac index, 7.8 L·min<sup>-1</sup>·m<sup>-2</sup>; central venous pressure (CVP), 12 mm Hg; pulmonary artery pressure, 42/28 mm Hg; pulmonary capillary
Human Immunodeficiency Virus Type 2 Infection in the United States
Authors: Thomas R. O'Brien
Journal: JAMA (1992)

WITHIN the past year, the US Food and Drug Administration (FDA) has licensed two combined human immunodeficiency virus type 1 (HIV-1)/human immunodeficiency virus type 2 (HIV-2) enzyme immunoassays (EIAs) for screening donated blood and plasma. The FDA has also mandated that by June 1, 1992, US blood centers must implement testing for antibodies to HIV-2 in addition to testing for antibodies to HIV-1. Implementation of this policy and reports of HIV-2—infected US residents have raised important public health and clinical questions about HIV-2 infection in the United States. This article summarizes current information regarding the epidemiology and diagnosis of HIV-2 infection and discusses public health considerations that arise from the presence of HIV-2 in the United States. <h3>BACKGROUND: WORLDWIDE DISTRIBUTION, TRANSMISSION, AND NATURAL HISTORY</h3> Infection with HIV-2 is endemic in many countries in West Africa, but generally much rarer elsewhere in the world.<sup>1,2</sup>The highest prevalence of HIV-2 infection
Misuse of Health Statistics
Authors: R. Edward Dodge
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Ludwig and Collette have performed an important and needed service in writing the article, "Some Misuses of Health Statistics" (<b>216</b>:493, 1971). However, they have also stumbled into one of the pitfalls they warn about. Their association of midwifery in the rural South with a high infant mortality in that region leads them to an unwarranted conclusions. The association cited is certainly not a valid argument against the expansion of midwifery in the United States, as they imply. Most midwives in the rural south are lay midwives. Approximately 4,400 were practicing in 1968.<sup>1</sup>By contrast, nurse-midwives in this country and most midwives in European countries are highly trained. The confusion by Ludwig and Collette of lay midwives (largely uneducated) with professionally trained midwives leaves their interpretation about this subject open to question. Further, many socioeconomic and environmental factors in the rural South may well have more
Enteric-Coated Potassium and Bowel Obstruction
Authors: Frederick Shuster
Journal: JAMA (1965)

<h3>To the Editor:—</h3> Within the past year, reports have appeared of ulcerative-obstructive small-bowel lesions in patients receiving entericcoated potassium chloride-thiazide combinations. Potassium salts rather than the thiazide diuretic have been implicated. The typical lesion is a well-demarcated circumferential ulceration occurring in the distal jejunum or ileum. Healing of the ulceration may leave a stenotic lesion, and combinations of ulceration and stenosis are frequent. Although the potassium-induced ulceration usually preceded and caused the stenotic obstructive lesion, a case is presented in which a preexisting partially obstructive lesion may have predisposed to the occurrence of the potassium-induced lesion at that site. A 29-year-old registered nurse was admitted to the Jackson Memorial Hospital after an episode of cramping periumbilical pain radiating around both sides to her back, worsened by eating and relieved by leaning forward. She vomited material with a "rotten egg" odor. In the preceding 12 years, she had had three similar
Handbuch der mikroskopischen Anatomie des Menschen.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Once More: The Pathogenic Effects of the Sickle Cell Trait
Authors: Paul Heller
Journal: JAMA (1973)

A few weeks ago, the National Academy of Sciences-National Research Council published an evaluation of the status of the S-hemoglobinopathies in the Armed Forces, with the recommendation that essentially no limitations in activity—except that of pilots and co-pilots—should be placed on persons with the sickle cell trait.<sup>1</sup>The study by Murphy on the frequency of the sickle cell trait in professional football players published in this issue on p 981 could have served as supporting evidence for that recommendation. Although Murphy's short report does not contain data on morbidity of these football players, it is crucial that these athletes had been exposed to the strains of one of the most demanding sports for many years and had competed successfully for admission to a major league. Can we now rest assured that the 2,000,000 blacks in this country and many more around the world who carry the sickle cell trait
OP0271 INCREASED RISK OF DEMENTIA IN PATIENTS WITH RHEUMATOID ARTHRITIS: A NATIONWIDE POPULATION-BASED COHORT STUDY
Authors: Y. Eun, K. D. Han, S. Y. Kang, S. Lee, H. S. Cha, E. M. Koh, J. Lee, H. Kim
Journal: Annals of the Rheumatic Diseases (2022)

Background There have been conflicting results of previous studies on the association between rheumatoid arthritis (RA) and the risk of dementia. Objectives In this study, we aimed to investigate the association between RA and dementia in a large nationwide population-based cohort. Methods Among patients diagnosed with RA between 2010 and 2017, patients who had undergone a national health examination within two years prior to RA diagnosis were included in the study (n = 138,592). Control group included age- and sex-matched non-RA controls who received a health check-up at the same time as RA patients (n = 692,960). The primary outcome of the study was incident dementia, which was defined by an ICD-10 code and the use of dementia medications. Kaplan-Meier curves and Cox proportional hazards regression analysis were used for the analysis. Results Mean follow-up duration of the study was 4.7 ± 2.2 years. RA patients had a 1.2 times higher risk of dementia than controls (adjusted hazard ratio [aHR] 1.19, 95% CI 1.16–1.23). In patients with RA, the aHR for Alzheimer’s disease (AD) was 1.21 (95% CI 1.67-1.25) and the aHR for vascular dementia (VD) was 1.10 (95% CI 0.99-1.21). In a stratified analysis according to age, gender, lifestyle factors and comorbidities, the association between RA and dementia was consistently found. Conclusion In a large nationwide population-based cohort, RA was associated with an increased risk of incident dementia. Appropriate evaluation of dementia is required when cognitive impairment occurs in RA patients. Further studies are warranted to identify mechanisms of increased risk of dementia in RA patients. Disclosure of Interests None declared