AB1610 NON-PHARMACOLOGICAL AND SELF-MANAGEMENT INTERVENTIONS FOR MAIN OUTCOMES IN RHEUMATOID ARTHRITIS PATIENTS: A SYSTEMATIC REVIEW
Authors: N. Nakhost Lotfi, P. Studenic, N. Weibrecht, G. Zauner, K. Fechner, T. Stamm, T. H. Jakobsen, T. S. Jørgensen, N. Popper, L. E. Kristensen, H. Radner
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Rheumatoid arthritis (RA) is accompanied by considerable limitation of the functional abilities and a significant reduction of the patients´ quality of life (QoL).<sup>[1]</sup> Self-management has been proven to play a role in the improvement of well-being and functioning in daily life. With the help of digital tools, individualized self-management methods can become more accessible to patients.<sup>[2]</sup> <h3>Objectives</h3> We aimed to identify evidence on efficacy of non-pharmacological self-management interventions on core outcomes in RA. Results will inform development of self-management recommendations into the RheumaBuddy (RB) 4.0 app. <h3>Methods</h3> To identify evidence-based self-management interventions suitable for the inclusion in the app, a systematic literature review (SLR) was conducted. We included clinical trials or randomized controlled trials in adult (≥18years) RA patients, reported in German or English language and excluded nutritional supplements and interventional medical devices. Outcomes of interest were identified via RB4.0 as either predefined or individually used for symptom tracking in the app and agreed upon in an expert panel. <h3>Results</h3> Main outcomes identified and used in the SLR were pain, fatigue, mood, stiffness, and quality of life. In total, 125 studies from 644 identified articles were included for data extraction (Figure 1). Heterogeneity of the studies precluded a meta-analysis. The majority of studies used pain (n=100), mood (n=46) or fatigue (n=35) as outcome. Interventions were grouped into six main categories (Exercise, Diet, Psychosocial, Education, Multicomponent, and other). The number of studies with a significant positive effect on various outcomes per various intervention strategies are displayed in Table 1. <h3>Conclusion</h3> We identified a broad range of non-pharmacological, self-management interventions for RA patients which can be used to further develop self-management recommendations, for implementation into RheumaBuddy 4.0, a new generation of an algorithm-driven digital health tool, designed to support RA patients' disease self-management. <h3>References</h3> [1] Boonen A, Severens JL. The burden of illness of rheumatoid arthritis. <i>Clin Rheumatol.</i> 2011;30 Suppl 1:S3-8. [2] Mollard E, Michaud K. Self-Management of Rheumatoid Arthritis: Mobile Applications. <i>Curr Rheumatol Rep.</i> 2020;23(1):2. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> Nasim Nakhost Lotfi: None declared, Paul Studenic Speakers bureau: AstraZeneca, Nadine Weibrecht: None declared, Günther Zauner: None declared, Katharina Fechner: None declared, Tanja Stamm: None declared, Thomas H Jakobsen Shareholder of: HealthBuddy Company, Tanja Schjødt Jørgensen: None declared, Nikolas Popper: None declared, Lars Erik Kristensen: None declared, Helga Radner: None declared.