tbuckley/cabot-search huggingface dataset:
Upper-Extremity Suppurative Thrombophlebitis and Septic Pulmonary Emboli
Authors: Gerald Weinberg
Journal: JAMA (1978)

THROMBOSIS of the deep veins of the upper extremity accounts for less than 2% of all deep-vein thromboses. The disease is a potentially serious condition and, in addition to causing the local complication, may be responsible for systemic manifestations. Adams and co-workers<sup>1</sup>reported 12% incidence of pulmonary emboli in a series of 25 patients with upper-extremity deep-vein thrombosis, and a similar incidence of pulmonary emboli originating from the veins of the upper extremities has been quoted by other authors.<sup>2</sup>An additional, possibly fatal complication of the upper-extremity deep thrombophlebitis occurred in the form of a septic embolization. <h3>Report of a Case</h3> A 33-year-old male heroin addict was admitted to a hospital complaining of pain in the right arm, malaise, dyspnea, and cough. Several weeks before admission, he attempted to inject heroin into his right antecubital vein. At the time of admission, his temperature was 38.9 °C, and he had
Medical schools in the United States
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Medic Alert Emblem: An Absolute Indication
Authors: Alan Jay Schwartz
Journal: JAMA (1978)

<h3>To the Editor.—</h3> Emergency medical therapy is riddled with many potentially disastrous complications less likely to occur in nonemergent situations that permit careful and thoughtful evaluation of history. The morbidity of drug reactions and interactions is intensified when medication history is unavailable, especially when a patient's medication is infrequently prescribed and relatively unfamiliar to the emergency physician. These are the exact conditions under which emergency treatment must be initiated for the unconscious or noncommunicative patient taking a monoamine oxidase inhibitor (MAOI). Substantial neurologic, cardiovascular, and hyperpyrexic toxic reactions are known to occur in patients taking an MAOI and given analgesics or anesthetics,<sup>1,2</sup>at times resulting in mortality. If the emergency physician is alert to this potential problem, he will avoid analgesics and modify a required anesthetic, thus reducing the potential risk. The medic alert emblem is a reliable method permitting patients to relate such critical historical facts at
Differential Sensitivities of Human Testicular and Bladder Tumor Cell Lines to Chemotherapeutic Drugs
Journal: JNCI Journal of the National Cancer Institute (1987)

The in vitro drug sensitivities of 5 human testicular tumor cell lines (Tera II, SuSa, NEC-8, 833K, T3B1) and 5 human bladder carcinoma cell lines (RT4, RT112, T24, HT1197, HT1376) were compared. Cytotoxicities of cisplatin and doxorubicin were assessed by inhibition of colony-forming ability during continuous exposure to a range of drug concentrations. The ranges of the drug concentrations required to kill 70% of clonogenic cells obtained against the testicular cell lines were 1–7 ng/ml and 21–161 ng/ml for doxorubicin and cisplatin, respectively, compared with 4–19 ng/ml and 112–431 ng/ml for the bladder cell lines. This study shows that continuous cell lines retain the relative clinical chemosensitivities of their tumors of origin. The results also indicate that testicular tumor cells are inherently more sensitive to the cytotoxic effects of chemotherapeutic drugs than are bladder cancer cells.
Manual of Diseases of the Nose and Throat.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Combined Text-Book of Obstetrics and Gynaecology.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immune Alterations Related to Age, Sex, and Mammary Tumor Detection in Murine Mammary Tumor Virus-Infected Mice
Journal: JNCI Journal of the National Cancer Institute (1982)

Journal Article Immune Alterations Related to Age, Sex, and Mammary Tumor Detection in Murine Mammary Tumor Virus-Infected Mice Get access Hervé Benoist, Hervé Benoist Pharmacy Teaching and Research Unit, University of Reims, F-51096 Reims, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Jean Dufer, Jean Dufer Jean Godinot Cancer Institute, F-51100 Reims, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Cécile Bouchet, Cécile Bouchet Laboratoire d'Immunologie, Réne Huguenin Cancer Center, 35 rue Dailly, F-92211 Saint Cloud, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Andrée Desplaces Andrée Desplaces Laboratoire d'Immunologie, Réne Huguenin Cancer Center, 35 rue Dailly, F-92211 Saint Cloud, France Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 69, Issue 6, December 1982, Page 1208, https://doi.org/10.1093/jnci/69.6.1208 Published: 01 December 1982
Treatment of Mushroom Poisoning
Authors: G. L. Floersheim
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The survey on mushroom poisoning by Hanrahan and Gordon<sup>1</sup>published inThe Journalcovered four types of toxic mushrooms, each illustrated by a clinical case. However, the section on amatoxin poisoning (caused by either<i>Amanita phalloides, Amanita virosa</i>, or<i>Amanita verna</i>) contains inaccuracies and fails to inform the reader about advances in therapy. The statement that the mortality of amatoxin poisoning was until recently 50% to 90% is misleading and likely to falsify the interpretation of therapeutic results. In a large study including 288 cases of<i>Amanita</i>("death cap") intoxications observed between 1919 and 1958 in Switzerland, the mortality rate was 30%.<sup>2</sup>In much smaller series of patients, a higher mortality may be occasionally recorded, but it is clear that large series are mandatory to assess the mortality rate correctly. In a newer series of 205 cases of<i>Amanita</i>intoxications that occurred in Europe from
Diagnosis and immunotherapy of mould allergy
Authors: H.‐J. Malling, P. Stahl Skov
Journal: Allergy (1988)

The interrelation of in vitro IgE‐mediated parameters, i.e. serum‐specific IgE (RAST), basophil cell‐bound specific IgE, and histamine release from basophil leucocytes was investigated in a 1‐year placebo‐controlled, double‐blind Cladosporium immunotherapy study involving 22 adult asthmatics. The intense and early burst (within 6 weeks of immunotherapy) of serum‐specific IgE did not result in a corresponding increased binding of specific IgE molecules to basophils. Cell‐bound IgE increased in the Cladosporium season in both groups at the same time as serum levels of specific IgE declined in the Cladosporium group. In the placebo group histamine release from circulating basophils paralleled changes in basophil‐bound IgE. In Cladosporium ‐treated patients, histamine release cell sensitivity after a lag phase (during immunotherapy dose‐increase) declined two log steps, i.e. the cells became less responding in spite of a significant increase in cell‐bound IgE. To further evaluate the sensitizing capacity of circulating specific IgE, passive sensitization studies were performed using basophils from a single donor. Although sera taken at the maximal IgE‐response showed an enhanced capacity of passive sensitization, the ratio between RAST and passive sensitization capacity increased significantly in Cladosporium ‐treated patients, implying a less than expected sensitization capacity of immunotherapy‐induced specific IgE. The lack of active binding of IgE to basophils might be explained by a reduced Fc‐affinity of immunotherapy‐induced IgE in contrast to the Cladosporium seasonally induced IgE. Regarding the decrease in histamine release in Cladosporium ‐treated patients in spite of an increased amount of cell‐bound specific IgE, immunotherapy may initiate a decrease in mediator releasibility which is not caused by a reduction in the number of Fc‐receptors but rather some yet unknown subcellular mechanisms regulating the histamine release. The described changes in IgE‐mediated parameters do not seem to be caused by interference with either specific IgG, or IgG4. Changes in histamine release in the Cladosporium , season were the only IgE‐mediated parameter significantly related to the graded clinical efficacy of immunotherapy.
Minor and Operative Surgery, Including Bandaging.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Counseling the HIV-Positive Woman Regarding Pregnancy
Authors: Frederick Hecht
Journal: JAMA (1987)

<h3>To the Editor.—</h3> Genetic counseling today is a nondirective process in the sense that patients are not told what they should do. In genetic counseling, the facts of the situation are determined and communicated to the patient together with the reproductive options, and the patient makes the decision.<sup>1</sup>This nondirective process has been applied to genetic and chromosome disorders as well as to environmental factors that may injure the fetus, such as radiation and chemical exposure. The nondirective nature of genetic counseling puts the informed decision making squarely in the hands of the patient and is part of the move toward greater patient autonomy. As Francis and Chin<sup>2</sup>have recently observed, "Human immunodeficiency virus (HIV) is one of the most virulent infectious agents ever encountered. This virus, estimated to kill up to half of those infected, has spread to more than 1 million Americans. There is no safe
PSD-95 expression controls l-DOPA dyskinesia through dopamine D1 receptor trafficking
Authors: Gregory Porras, Amandine Berthet, Benjamin Dehay, Qin Li, Laurent Ladepeche, Elisabeth Normand, Sandra Dovero, Audrey Martinez, Evelyne Doudnikoff, Marie-Laure Martin-Négrier, Qin Chuan, Bertrand Bloch, Daniel Choquet, Eric Boué-Grabot, Laurent Groc, Erwan Bezard
Journal: Journal of Clinical Investigation (2012)

l-DOPA–induced dyskinesia (LID), a detrimental consequence of dopamine replacement therapy for Parkinson’s disease, is associated with an alteration in dopamine D1 receptor (D1R) and glutamate receptor interactions. We hypothesized that the synaptic scaffolding protein PSD-95 plays a pivotal role in this process, as it interacts with D1R, regulates its trafficking and function, and is overexpressed in LID. Here, we demonstrate in rat and macaque models that disrupting the interaction between D1R and PSD-95 in the striatum reduces LID development and severity. Single quantum dot imaging revealed that this benefit was achieved primarily by destabilizing D1R localization, via increased lateral diffusion followed by increased internalization and diminished surface expression. These findings indicate that altering D1R trafficking via synapse-associated scaffolding proteins may be useful in the treatment of dyskinesia in Parkinson’s patients.
Capillary Basement Membrane Changes in Adolescents With Type 1 Diabetes
Authors: Robert L. Jackson
Journal: JAMA (1982)

Measurements were made of muscle capillary basement membrane thickness (CBMT) in 95 normal boys and girls and 167 postpubescent insulin-dependent diabetics. Of 110 diabetics in whom "higher" degrees of metabolic control were maintained, only two had increased CBMT values. Of 57 diabetics in whom "lower" degrees of metabolic control were maintained, 26 had increased CBMT values. Two or more muscle biopsies were done in each of 65 diabetic subjects: Mean CBMT values of 24 subjects with "higher" degrees of metabolic control for two to nine years remained within the normal range; values of 23 subjects with "lower" degrees of metabolic control for only one to three years increased from 858±142 A to 1,155 ± 227 A; values of 13 subjects who had been in "lower" degrees of control decreased from 1,255 ±232 A to 869 ±135 A after maintaining "improved" metabolic control for about a year. In postpubescent diabetics, the CBMT is labile and progresses or regresses depending on the degree of metabolic control. (<i>JAMA</i>1982;248:2143-2147)
The Status of Women at One Academic Medical Center
Authors: Katherine G. Nickerson
Journal: JAMA (1990)

Despite recent gains in admission to medical school and in obtaining junior faculty positions, women remain underrepresented at senior academic ranks and in leadership positions in medicine. This discrepancy has been interpreted as evidence of a "glass ceiling" that prevents all but a few exceptional women from gaining access to leadership positions. We analyzed data from Columbia University College of Physicians &amp; Surgeons, New York, NY, for all faculty hired from 1969 through 1988 and found that the likelihood of promotion on the tenure track was 0.40 for women and 0.48 for men (ratio, 0.82; 95% confidence interval, 0.56 to 1.20); on the clinical track the likelihood of promotion was 0.75 for women and 0.72 for men (ratio, 1.04; 95% confidence interval, 0.56 to 1.94). Additional analysis of current faculty showed that in the academic year 1988-1989 the proportion of women at each tenure track rank at the College of Physicians &amp; Surgeons equaled or exceeded the national proportion of women graduating from medical school, once allowance was made for the average time lag necessary to attain each rank. On the clinical track women were somewhat overrepresented, particularly at the junior rank. National data that describe medical school faculty, which combine tenure and clinical tracks, showed that in 1988 women were proportionately represented at each rank once the lead time from graduation was considered. We conclude that objective evidence shows that women can succeed and are succeeding in gaining promotions in academic medicine. (<i>JAMA</i>. 1990;264:1813-1817)
Inhibition of sodium-hydrogen exchange reduces infarct size in the isolated rat heart -- a protective additive to ischaemic preconditioning
Authors: E. Bugge, K. Ytrehus
Journal: Cardiovascular Research (1995)

Objectives: Inhibition of Na+/H+ exchange with amiloride analogues has been shown to protect the ischaemic and reperfused heart. The aim of this study was to examine if preischaemic or postischaemic treatment with the selectiveNa+/H+ exchange inhibitor ethyl-isopropyl amiloride (EIPA, 1 μM) influenced infarct size in an isolated rat heart model of regional ischaemia and reperfusion, and if any such protection was additive to the protection afforded by ischaemic preconditioning.Methods: Langendorff perfused rat hearts were subjected to 30 or 45 min of regional ischaemia and 120 min of reperfusion. The risk zone was determined by fluorescent particles and infarct size was determined by staining with triphenyltetrazolium chloride. Results: Treatment with EIPA for 20 min before 30 min regional ischaemia significantly reduced infarct size (in % of the risk zone) compared to untreated controls [3.1(SEM 1.0)% ν 38.1(5.8)%, P<0.001], a protection similar to that afforded by ischaemic preconditioning [6.1(2.5)%]. Combination of preischaemic EIPA treatment and ischaemic preconditioning also reduced infarct size [5.2(2.0)%, P < 0.01 ν control group]. When EIPA was added to the buffer only during the first 30 min of reperfusion, no protection was observed [infarct size = 37.8(5.8)%, NS ν control group]. In order to clarify if the protection observed with EIPA treatment was additive to protection by ischaemic preconditioning, another set of experiments was performed. In these experiments regional ischaemia was extended to 45 min. Preischaemic EIPA treatment reduced infarct size also in this model compared to controls [15.3(2.9)% ν 64.3(2.9)%, P < 0.001], as did ischaemic preconditioning [23.5(4.2)%, P < 0.001 ν controls, NS ν EIPA treated hearts]. Combination of ischaemic preconditioning and preischaemic EIPA treatment further reduced infarct size significantly [3.9(0.6)%, P < 0.05 ν all other groups with 45 min regional ischaemia]. Conclusions: Inhibition of Na+/H+exchange reduces infarct size in the isolated rat heart infarct model if the exchanger is inhibited during the ischaemic period, and this protection is additive to the protection afforded by ischaemic preconditioning.
Secretagogue Response in Rat Pancreatic Acinar Carcinoma&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Warren, John R.
Journal: JNCI Journal of the National Cancer Institute (1982)

The secretion of protein, like cell proliferation, is an integrated response that reflects structural organization of the cell periphery. Stimulation of protein secretion was thus utilized for comparison of integrated responses of the cell periphery in pancreatic acinar carcinoma of the rat and integrated responses in normal rat pancreas. Results of this comparison include: a) The stimulation of protein secretion in acinar carcinoma fragments by carbamylcholine chloride and cholecystokinin octapeptide, pancreatic secretagogues that interact with specific plasma membrane receptors, was only a fraction (one-fifth to one-half) of that observed in normal pancreatic minilobules. b) The Ca2+ ionophore A23187 and the cyclic nucleotide N6,O2'-dibutyryl cyclic AMP, secretagogues that act independently of specific membrane receptors, did not stimulate secretion in the acinar carcinoma. The observed quantitative and qualitative differences in protein secretion indicate fundamental differences in cell periphery organization between the normal and transformed acinar cells of pancreas.
Treatise on the Diseases of Women, for the use of Students and Practitioners.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serratia marcescens Arthritis Requiring Amputation
Authors: Ernest Atlas
Journal: JAMA (1968)

A case of pyogenic arthritis caused by the organism<i>Serratia marcescens</i>is believed to be the first reported in the American literature. The patient presented initially with ocular signs, following by calf pain and tenderness, mistakenly interpreted as thrombophlebitis, and finally refractory pyogenic arthritis which led to amputation.