tbuckley/cabot-search huggingface dataset:
A Practical Treatise on Materia Medica and Therapeutics.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Traumatic perforation of oesophagus.
Authors: K F Schiller, P B Cotton
Journal: BMJ (1972)

54 patients with localized or primary malignant melanoma had circulating cytoplasmic antibody.A few patients formerly positive but who had converted to negative, and some who on clinical grounds had a primary lesion but who had negative tests for cytoplasmic antibody, were found to have developed metastatic lesions.It is postulated that the halo naevus represents a seldom seen interim stage natural protective mechanism-that is, a rejection phenomenon of malignant melanoma.It is the visualization, so to speak, of the sur- veillance system normally so effective in pre- venting malignant melanoma from developing in every individual.The study of such aspects in the behaviour of moles and melanomas raises the question not only why are halo naevi spontaneously rejected and heal, but why do malignant melanomas de- velop and persist in patients who in all other respects appear to have normal and intact immunological mechanisms.-Weare, etc.,
Psychiatric Implications of Missile Attacks on a Civilian Population
Authors: Avi Bleich
Journal: JAMA (1992)

<h3>Objective.</h3> —To determine the proportion of hospitalized patients who had stress reactions as a result of missile attacks during the Persian Gulf War and evaluate the factors that influenced their evacuation. <h3>Design.</h3> —Review of medical records of patients hospitalized as a result of missile attacks. <h3>Setting.</h3> —During the Persian Gulf War in the winter of 1991, Israel received 18 missile attacks involving 39 surface-to-surface Scud missiles. The uncertainty in time, place, and type of warhead, conventional or chemical, was a source of chronic stress and the immediate cause for many traumatic stress reactions at or near the missile attack sites. <h3>Participants.</h3> —Data from victims who were injured after each missile attack were available through a central hookup between 12 local hospitals and the Medical Corps of the Israeli Defence Force. <h3>Main Outcome Measure.</h3> —The number of persons diagnosed in the hospital as psychological casualties after each missile attack. <h3>Results.</h3> —Approximately 43% of the 773 casualties evacuated to hospitals were diagnosed as psychological casualties, and an additional 27% had mistakenly injected themselves with atropine. Data also indicated that triage of psychological casualties to hospitals was more a function of the rescue team's training and preparation than the severity or extent of injury or damage. <h3>Conclusions.</h3> —Optimal treatment during events that cause mass casualties requires proper preparation of rescue teams as well as reorganization of the hospital's psychiatric services. The threat of chemical warfare affected the number and nature of stress reactions. (<i>JAMA</i>. 1992;268:613-615)
Treatment of Mild Hypertension With Diuretics
Authors: Ingar Holme
Journal: JAMA (1984)

The Multiple Risk Factor Intervention Trial (MRFIT) showed that diuretic treatment of hypertensive men with certain ECG abnormalities at entry was associated with an increased coronary heart disease mortality in the special-intervention group as compared with the usual-care group. Following the same criteria for resting ECG abnormalities as in MRFIT, The Oslo Study trial of mild hypertension has been reanalyzed for similar effects. Although numbers of first coronary events are low in this study (20 cases in the treated group and 13 in the control group), similar trends are present in The Oslo Study. The excess of seven cases of coronary events in the Oslo treatment group can mainly be explained by introduction of the MRFIT ECG-Minnesota codes. (<i>JAMA</i>1984;251:1298-1299)
Disulfiram-like Reaction to -Lactams
Authors: M. K. Buening, J. S. Wold, K. S. Israel, R. B. Kammer
Journal: JAMA (1981)

<h3>To the Editor.—</h3> The letter describing disulfiram-like reactions in subjects taking cefoperazone (1980;243:2397) asked (1) "Which other cephalosporins might also produce this reaction?" and (2) "Is acetaldehyde increased during these reactions?" In other reports, disulfiram-like reactions are described in subjects taking cefoperazone,<sup>1,2</sup>moxalactam disodium,<sup>3</sup>and cefamandole sodium.<sup>4</sup>Disulfiram-likereactions have also occurred in two subjects who ingested alcohol after completing a multiple-dose study with moxalactam in the Lilly Laboratory for Clinical Research, Wishard Memorial Hospital. These subjects received intravenous doses of 4 g of moxalactam disodium every eight hours for seven doses. About 30 hours later, one subject ingested alcohol and within one-half hour had facial flushing, nausea, vomiting, and dizziness. After he fainted and was brought to the hospital, his blood alcohol concentration was 64 mg/dL. His blood pressure was 90/60 mm Hg in the supine position, and his pulse rate was 100 beats per minute
Highlights of This Issue
Journal: Clinical Cancer Research (2013)

Clinical differentiation between follicular thyroid carcinoma and adenoma presents a diagnostic challenge that often leads to unnecessary thyroidectomies. Levi and colleagues explored the utility of molecular photoacoustic imaging as a noninvasive method for detection of follicular thyroid cancer. Dual wavelength imaging of the matrix-metalloproteinase–activated photoacoustic probe revealed efficient activation and high accumulation of the probe in follicular tumors in mice. The combination of the intrinsic qualities of photoacoustic imaging and specificity that a molecular imaging agent imparts promises a safe, noninvasive, and inexpensive technique that can allow early diagnosis of follicular thyroid carcinomas.Pronounced interindividual pharmacokinetic variability is common with tyrosine kinase inhibitors (TKI) and may have implications for their clinical efficacy and toxicity. TKIs are extensively metabolized in the liver, but mechanisms of hepatocyte uptake remain unclear. After initial evaluation of TKI transport by OATP1B uptake carriers in vitro, Zimmerman and colleagues investigated the influence of these transporters on sorafenib elimination in transfected cell models as well as in transporter knockout and humanized mice. This study sheds light on factors affecting the elimination of sorafenib and its glucuronide conjugate and provides a framework for future investigations aimed at elucidating mechanisms of TKI pharmacologic variability.Radiation therapy is an accepted treatment for prostate cancer; however, no commonly used factors predict outcome specifically following this treatment. Schoenfeld and colleagues identified an association between genetic variation in the inflammation-related RNASEL gene and outcome following prostate radiotherapy in a large cohort of men followed for cancer-specific outcomes. This association was not found in patients derived from the same cohort treated with radical prostatectomy. These data suggest that inherited variation in RNASEL may predict outcome following radiation therapy in a treatment-specific manner that could eventually be used to help guide treatment.Gemtuzumab-ozogamicin (GO), an anti-CD33 monoclonal antibody conjugated to calicheamicin, is a promising agent for treatment of acute myeloid leukemia (AML). Although GO has shown efficacy in a subset of patients, clinical response to it is heterogeneous, emphasizing the need for a better understanding of factors to identify patients who will or will not benefit from this treatment. Mortland and colleagues evaluated genetic variation in CD33 and identified coding polymorphisms predictive of clinical outcome in AML patients receiving a combination of the ADE regimen (cytarabine/daunorubicin/etoposide) and GO. Integration of this information as an independent prognostic marker into current cytogenetic/molecular-based risk classification models would present an opportunity to increase our accuracy in forecasting therapeutic outcome in AML.
Some benefit of concurrent chemo-radiotherapy in cancer
Authors: Tom Hager
Journal: JAMA (1983)

Simultaneous radiotherapy and chemotherapy may be useful in the treatment of both limited small-cell lung cancer and advanced Hodgkin's disease, according to reports presented at the recent meeting of the American Society of Clinical Oncology in San Diego. This adds to the evidence already gathered on the efficacy of this combination therapy in other types of cancer, such as breast cancer (<i>JAMA</i>[MEDICAL NEWS] 1982;248:1799-1801). Although such combined use of drugs and radiation therapy (RT) sometimes results in an increase in adverse effects in patients, the benefits of these new, more intensive regimens may outweigh the dangers in some patients. A multicenter randomized trial conducted by the Southeastern Cancer Study Group, Birmingham, Ala, has shown that administering thoracic radiation therapy simultaneously with chemotherapy can improve results in the treatment with limited small-cell carcinoma of the lung. A total of 304 patients were divided into two groups, matched by age and
Editorial board and contents
Authors: Richard Pearson, Hans De Kroon, Liesje Mommer, Johanna Mehta, Timo Vuorisalo, James Miller, Craig Hadley, Michael Taborsky, Jonathan Chase, Henrique Pereira, H David Cooper, Benoit Facon, Benjamin Genton, Jacqui Shykoff, Philippe Jarne, Arnaud Estoup, Patrice David, Mark Boyce, Chirakkal Haridas, Charlotte Lee, Gareth Jones, Emma Teeling, Bruce Macfadden Trendsin, Katrina Lythgoe, Linsey Stapley, Lisa Norman, Manager Moulton
Journal: Trends in Ecology & Evolution (2006)
Modern Methods OF Treatment.
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Atrioventricular Block Induced by Swallowing in a Patient With Diffuse Esophageal Spasm
Authors: Mauro Bortolotti
Journal: JAMA (1982)

A patient had syncope induced by swallowing. Electrocardiographic monitoring during eating and esophageal balloon inflation demonstrated a second-degree atrioventricular block (Mobitz type II) with dizziness. Radiologic and manometric examinations of the esophagus showed diffuse esophageal spasm associated with hypertension of the upper esophageal sphincter (UES), gastroesophageal reflux, and a sliding hiatal hernia. Cineradiographic observations were made during ingestion of a meal mixed with barium; at the time of cardiac dysrhythmia, the proximal part of the esophagus containing the bolus assumed a balloonlike shape, while the distal part and the UES contracted. On the basis of these observations and review of all published cases, we propose the pathways of this esophagocardiac reflex and discuss up-to-date treatment. (<i>JAMA</i>1982;248:2297-2299)
Highlights from Recent Cancer Literature
Journal: Cancer Research (2016)

Inhibiting Aggregation Restores p53 FunctionIn some cancers, mutant p53 protein accumulates in a self-aggregated amyloid-like state.Studying p53-mutant high-grade, serous ovarian carcinoma (HGSOC), Soragni and colleagues demonstrate that a cell-penetrating peptide (ReACp53) inhibits p53 amyloid formation.Peptide treatment switched the balance from nonfunctional p53 aggregates to soluble functional protein.The resolubilized p53 relocated to the nucleus and regulated target genes.Like wild-type p53, it halted cell proliferation and triggered apoptosis in cell lines and HGSOC patient-derived organoids.Intraperitoneal administration of the peptide decreased tumor proliferation, shrank HGSOC xenografts, and was effective against even intraperitoneally disseminated tumors.Given the prevalence of p53 mutations, ReACp53 could be effective in many different cancer types, although it remains to be determined which of the thousands of described p53 mutants, other than the wellestablished aggregation-prone ones, will respond.(Image courtesy of Wikimedia Commons.)
Lehrbuch der physiologischen Chemie in Vorlesungen.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Researchers Look Forward to Sea Granting Gifts
Authors: Marsha F. Goldsmith
Journal: JAMA (1996)

"ALL THAT WE DO," wrote Richard Wilbur, "is touched with ocean, yet we remain on the shore of what we know." Scientists searching the sea for new drugs to treat human diseases seem to take the poet's words as a given and a challenge. More than 120 drugs developed from the traditional source, soil microorganisms, are used today to treat infectious diseases, cancer, and other ills. But a dramatic decline in discoveries based on soil microorganisms—more than 95% of new "drug leads" derived from them today turn out to be already known antibiotics—and increasing resistance to existing drugs, has led enterprising investigators to search the waters of the earth for medically useful microbes. "Marine microorganisms are, by comparison [with soil organisms], poorly known biologically," observes William Fenical, PhD, professor of oceanography at Scripps Institution of Oceanography's Center for Marine Biotechnology and Medicine at the University of California, San Diego, in
Massage and Medical Gymnastics.
Journal: JAMA (1922)

Since the war, physicians have been taking a deep interest in those therapeutic adjuncts embodied under the general term of physical reconstruction—occupational therapy, physical therapy (the latter includes massage), mechanotherapy, hydrotherapy and medical gymnastics. This book makes one realize that we have gone only a short distance in our knowledge of physical reconstruction methods, as concerns massage and medical gymnastics especially. The book opens up a broad field of research and endeavor for our entire profession, and especially for those who have learned the lesson that our end-results will be judged henceforth by the amount of functional restoration secured for our patients. At the outset, the author corrects false impressions spread by some teachers and practitioners, retarding the adoption of physical therapy. Claims and misstatements which have brought the method into disrepute with the scientific minds in the medical profession form a handicap which a true, scientific form of physiotherapy
Talc Granulomas of the Skin
Authors: Mauray J. Tye
Journal: JAMA (1966)

SURGICAL GLOVE TALC can cause granulomas in various intestinal and pelvic organs.<sup>1</sup>In the skin, localized silica granulomas due to the glove talc have been observed in surgical scars<sup>2,3</sup>and as the result of the impregnation of the skin by silicious particles, such as glass or sand, following an injury.<sup>' 5</sup>Extensive talc granulomas of the skin have not been reported, to our knowledge. <h3>Report of a Case</h3> A 45-year-old woman was admitted to the hospital because of the development of increasing numbers of lumps on her shoulders, buttocks, and thighs. These nodules had been developing for the past two years and were at sites where she has had as many as 500 boils over the past eight to ten years. Many of these boils were treated by incision and drainage. The nodules have not appeared on areas of the body where she has not had furuncles. She also
Landmark perspective: The ascent and decline of chloroquine
Authors: D. J. Wyler
Journal: JAMA (1984)

The article by Harry Most and colleagues in a 1946 issue ofThe Journalwas the first report in the American medical literature on the efficacy of chloroquine (a 4-aminoquinoline) as an antimalarial agent in humans. This study of roughly 300 military personnel who had acquired vivax malaria during World War II demonstrated the superiority of chloroquine over quinacrine (the only synthetic antimalarial compound used clinically at that time) and quinine (an active alkyloid present in cinchona bark extracts, which were used for centuries). The report represented a milestone on the long and winding road toward a highly efficacious and relatively nontoxic synthetic antimalarial agent (reviewed in detail in reference 1) and began a period of about three decades during which the drug served an important role in malaria control programs in endemic areas. Unfortunately, the days of chloroquine's greatest glory were numbered. In 1961, the first report<sup>2</sup>of
Carcinogen-Induced Tumors of the Thymus. III. Restoration of Neonatally Thymectomized Mice With Thymomas in Cell-Impermeable Chambers&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1969)

Neonatally thymectomized C3Hf/Bi mice could be restored immunologically (skin allograft rejection, graft-versus-host capacity, and delayed hypersensitivity to sheep red cells) by implantation of cell-impermeable diffusion chambers (0.22 or 0.10 μ average pore size filters) containing syngeneic or allogeneic nonlymphoid functional thymomas or normal thymus from 20-day-old donors. Three functional thymomas were equally effective in restoring the thymectomized hosts. The treatment was performed at 20 days of age and the chambers were implanted intraperitoneally. Ten other tumors of thymic and nonthymic origin could not restore the thymectomized hosts when implanted in diffusion chambers. A variety of normal tissues (spleen, lymph nodes, Peyer's patches, cecal appendix, submaxillary gland, liver, ovary, adrenal, thyroid, or hypophysis) as well as empty diffusion chambers could not induce any immunological restoration when implanted within cell-impermeable chambers into neonatally thymectomized mice. Diffusion chambers made with plastic rings and cemented filters of 0.45 or 0.30 μ average pore filter allowed passage of significant numbers of cells both within and outside the chambers. The chambers prepared with the 0.22 or 0.10 μ pore size did not permit cell traffic.
Dynamic Aspects of Nutrition and Heredity.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Atrioventricular Node and Selected Cardiac Arrhythmias.
Journal: Annals of Internal Medicine (1964)

marily dealing with various aspects of cardiac and coronary disease, which will be of considerable value to the reader.The book will be of considerable interest to nurses and to those physicians who wish to understand more about how first-class nursing care can be given to patients if the nurses are instructed in the proper philosophy and roles of her mission.