tbuckley/cabot-search huggingface dataset:
STUDIES ON INSULIN
Authors: G. A. H.
Journal: Annals of Internal Medicine (1936)

Editorial1 April 1936STUDIES ON INSULING. A. H.G. A. H.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-10-1437 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEver since its discovery almost fifteen years ago, many attempts have been made to render insulin still more effective as a clinical agent in the treatment of diabetes. These have taken two general directions: one, to find a more convenient and less difficult method of administration; and the other, to enhance its potency and to prolong the period of its physiological action. The chemical nature of this hormone, with its protein-like structure, probably renders it dependent for its physiological effects upon the molecular arrangement of its seven characteristic amino-acids. This structure also makes it vulnerable to attack by the digestive... HILLHOWITT DWFO: Insulin: its production, purification and physiological action, London, 1936. Google Scholar MAJOR RH: The intranasal application of insulin, Jr. Lab. and Clin. Med., 1935, xxi, 278-280. Google Scholar CLAUSENLOTTRUP VMC: Experiences with the treatment of diabetes with insulin—epinephrine, Ugesk. f. Laeger., 1935, xcvii, 747-750. Google Scholar PŘIBRAM H: Clinical observations on percutaneous insulin action in diabetic patients, Klin. Wchnschr., 1935, xiv, 1534. Google Scholar HERMANNKASSOWITZ SH: Experimental foundations of percutaneous insulin action, Klin. Wchnschr., 1935, xiv, 1531. CrossrefGoogle Scholar SCOTTFISHER DAAM: Prolongation of insulin action by protamine and zinc, Proc. Soc. Biol. Chem., 1936, lxxxviii. Google Scholar KRARUP NB: Clinical investigations into the action of protamine insulinate, Copenhagen, 1935. Google Scholar HAGEDORNNORMAN JENSENKRARUPWODSTRUP HCBNBI: Protamine insulinate, Jr. Am. Med. Assoc., 1936, cvi, 177. CrossrefGoogle Scholar ROOTWHITEMARBLESTOTZ HFPAEH: Clinical experience with protamine insulinate, Jr. Am. Med. Assoc., 1936, cvi, 180. CrossrefGoogle Scholar HANSSEN P: Enlargement of the liver in diabetes mellitus, Jr. Am. Med. Assoc., 1936, cvi, 914. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1936Volume 9, Issue 10Page: 1437-1439KeywordsHormonesInsulinProtein structure Issue Published: 1 April 1936 PDF downloadLoading ...
Psychotherapie: Ein Lehrbuch für Studierende und Ärzte
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Assessing quality
Authors: J. T. Kelly
Journal: JAMA (1988)

As concerns about the quality of medical care have increased, efforts to assess the quality of medical care have expanded significantly.<sup>1-3</sup>In response to questions about the quality of military medical care, the Department of Defense has established an innovative system to evaluate and improve the quality of care provided to Department of Defense beneficiaries.<sup>4</sup>The Department of Defense system is particularly noteworthy because it illustrates the likely direction for evolution in quality assessment systems. The strengths and potential weaknesses of the Department of Defense system deserve the close attention of the profession. The Department of Defense uses a panel of civilian physicians to establish review criteria for selected diagnoses and procedures. These criteria are then incorporated into computer algorithms. A sample of cases is randomly selected from each of the selected diagnoses and procedures, and the medical records for these cases are abstracted and placed on computer
Months of Butterrum
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Boxing Lacerations
Authors: D. Ralph Millard
Journal: JAMA (1962)

<h3>To the Editor:—</h3> As a former amateur boxer and now as a plastic surgeon, I have been interested in the problem of boxing lacerations. Many a fight has been lost by a TKO due to a cut when the lacerated fighter was actually winning the bout. This is unsatisfactory not only because the majority of lacerations are of little consequence but are caused by a head butt which is itself a foul. In a frantic attempt to stop the bleeding and prevent a loss of the fight on a technicality the corner cut man fills the wound with escharotics and greases. As the contest continues, the wound is torn wider and is pounded with bacteria, increasing the chance of infection. Thus, it seemed that immediate suturing of a laceration during the one-minute corner rest period could be an answer as it would check hemorrhage, clear vision, reduce infection, and prevent
Bedside Diagnosis
Authors: S. C. Truelove
Journal: BMJ (1963)

<h3>Abstract</h3> <i>Candida</i> yeasts causing human infections are spread across the yeast phylum with <i>Candida glabrata</i> being related to <i>Saccharomyces cerevisiae, Candida krusei</i> grouping to <i>Pichia spp.</i>, and <i>Candida albicans, Candida parapsilosis</i> and <i>Candida tropicalis</i> belonging to the CTG-clade. The latter lineage contains yeasts with an altered genetic code translating CUG codons as serine using a serine-tRNA with a mutated anticodon. It has been suggested that the CTG-clade CUG codons are mistranslated to a small extent as leucine due to mischarging of the serine-tRNA(CAG). The mistranslation was suggested to result in variable surface proteins explaining fast host adaptation and pathogenicity. Here, we re-assessed this potential mistranslation by high-resolution mass spectrometry-based proteogenomics of multiple CTG-clade yeasts, various <i>C. albicans</i> strains, isolated from colonized and from infected human body sites, and <i>C. albicans</i> grown in yeast and hyphal forms. Our <i>in vivo</i> data do not support CUG codon mistranslation by leucine. Instead, (i) CUG codons are mistranslated only to the extent of ribosomal mistranslation with no preference for specific amino acids, (ii) CUG codons are as unambiguous (or ambiguous) as the related CUU leucine and UCC serine codons, (iii) tRNA anticodon loop variation across the CTG-clade yeasts does not result in any difference of the mistranslation level, and (iv) CUG codon unambiguity is independent of <i>C. albicans</i>’ strain pathogenicity or growth form.
PTU-037 Loss of TLR 2 and 4 on ileal plasmacytoid dendritic cells in post-operative Crohn's disease patients
Authors: A U Murugananthan, D O Bernardo, C T Tee, N Arebi, S C Knight, H O Al-Hassi
Journal: Gut (2010)

<h3>Introduction</h3> Aberrant responses to bacterial flora are implicated in post-operative recurrence of Crohn9s disease (CD) after ileo-ceacal resection. Response to gut flora is conducted by dendritic cells (DC) which can induce a tolerogenic or active immune response. DC express Toll like receptors (TLR) which recognise bacterial products and are important in immune tolerance in health and highly expressed in IBD colonic tissue. Two subsets of DC are plasmacytoid (PDC) and myeloid cells (MDC). These DC show functional differences in their response to bacteria and are able to cross-talk. Expression of TLR on DC in the small intestine of post-operative CD patients is still largely unknown. We aimed to assess expression of TLR on DC from lamina propria mononuclear cells (LPMC) in post-operative CD patients as compared with normal controls. <h3>Methods</h3> Small intestine biopsies were obtained from 18 post-operative CD patients and 5 controls by colonoscopy. LPMC were collected using collagenase digestion, labelled with monoclonal antibodies to TLR2 and 4 and assessed by multicolour flow cytometry. <h3>Result</h3> A high percentage of DC from normal ileum expressed TLR2 and 4 with no significant differences in expression between PDC and MDC. However, expression of TLR 2 and 4 was significantly lower in PDC from post op CD patients compared with PDC in normal controls (mean 22.30% vs 60%, p=0.0003 and 38.55% vs 65.16%, p=0.02), respectively. Furthermore, PDC and MDC differed in expression of TLR2 and 4 in tissues from post-op CD patients; PDC expressed significantly less TLR2 and 4 compared with MDC (22.30% vs 38.11%, p=0.002 and 38.55% vs 50.89%, p=0.01), respectively. <h3>Conclusion</h3> Reduction of TLR2 and 4 expression in PDC compared with their counterparts in normal controls is likely to be the reason for the reduced expression of both TLRs on PDC compared with MDC in CD tissues. The lack of TLR2 and 4 expression on PDC maybe related to the disease activity as the normal controls did not show any statistical differences in expression of either TLR between the DC subsets. Other groups have suggested that functional differences exist between PDC and MDC in their activation by bacterial products and ability to produce innate and acquired inflammatory responses. In particular, blood PDC require the presence of MDC to respond to bacterial products to activate T cells rather than driving innate immunity. Our results indicate that PDC response to intestinal microflora may differ from that in MDC and provide initial background to the DC function and diversity in post-operative CD recurrence.
Tissue Engineering of Pulmonary Heart Valves on Allogenic Acellular Matrix Conduits
Authors: Gustav Steinhoff, Ulrich Stock, Najibulla Karim, Heike Mertsching, Adine Timke, Rolf R. Meliss, Klaus Pethig, Axel Haverich, Augustinus Bader
Journal: Circulation (2000)

Background —Tissue engineering using in vitro–cultivated autologous vascular wall cells is a new approach to biological heart valve replacement. In the present study, we analyzed a new concept to process allogenic acellular matrix scaffolds of pulmonary heart valves after in vitro seeding with the use of autologous cells in a sheep model. Methods and Results —Allogenic heart valve conduits were acellularized by a 48-hour trypsin/EDTA incubation to extract endothelial cells and myofibroblasts. The acellularization procedure resulted in an almost complete removal of cells. After that procedure, a static reseeding of the upper surface of the valve was performed sequentially with autologous myofibroblasts for 6 days and endothelial cells for 2 days, resulting in a patchy cellular restitution on the valve surface. The in vivo function was tested in a sheep model of orthotopic pulmonary valve conduit transplantation. Three of 4 unseeded control valves and 5 of 6 tissue-engineered valves showed normal function up to 3 months. Unseeded allogenic acellular control valves showed partial degeneration (2 of 4 valves) and no interstitial valve tissue reconstitution. Tissue-engineered valves showed complete histological restitution of valve tissue and confluent endothelial surface coverage in all cases. Immunohistological analysis revealed cellular reconstitution of endothelial cells (von Willebrand factor), myofibroblasts (α-actin), and matrix synthesis (procollagen I). There were histological signs of inflammatory reactions to subvalvar muscle leading to calcifications, but these were not found in valve and pulmonary artery tissue. Conclusions —The in vitro tissue-engineering approach using acellular matrix conduits leads to the in vivo reconstitution of viable heart valve tissue.
Gerontologia Clinica, Basel
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manual of Urology
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of using different antidiabetic drugs on demographic and clinico-pathological characteristics of breast cancer
Authors: M.A. Sendur, S. Aksoy, O. Yazici, N. Ozdemir, D.S. Dede, M.B. Akıncı, B. Yalçın, N. Zengin, K. Altundag
Journal: Annals of Oncology (2016)
Assessment of 1,3-Butadiene Exposure in Polymer Production Workers Using HPRT Mutations in Lymphocytes as a Biomarker
Authors: Marinel M. Ammenheuser, William E. Bechtold, Sherif Z. Abdel-Rahman, Judah I. Rosenblatt, Darlene A. Hastings-Smith, Jonathan B. Ward
Journal: Environmental Health Perspectives (2001)

1,3-Butadiene (BD), which is used to make styrene-butadiene rubber, is a potent carcinogen in mice and a probable carcinogen, associated with leukemia, in humans. We have previously used HPRT mutation as a biomarker to evaluate exposures to BD in a monomer production plant. We now report on a study of 49 workers in a styrene-butadiene rubber plant in which we used the concentration of the BD metabolite 1,2-dihydroxy-4-(N-acetylcysteinyl-S)-butane (M1) in urine as a biomarker of exposure and the frequency of HPRT variant (mutant) lymphocytes (Vf) as a biomarker of effect. Workers were assigned to high- and low-exposure groups based on historical information about work areas and jobs. Personal exposure to BD for one work shift was measured using a passive badge dosimeter. Each participant provided a urine specimen and blood sample at the end of the work shift and completed a questionnaire providing information on lifestyle, health, and work activities. The average BD exposures in the high- and low-exposure groups were significantly different, even after excluding two extreme values, (high 1.48 ppm; low 0.15 ppm, p < 0.002). This study was done in 1994 and 1995 before the establishment, in 1996, of the new permissible exposure limit of 1 ppm. Both the mean M1 and the HPRT Vf were more than three times greater in the high-exposure group than in the low-exposure group (p < 0.0005). The three end points correlated with each other, with sample correlation coefficients between 0.4 and 0.6. The correlations among BD exposure and the biomarkers of internal exposure and genotoxicity suggest that occupational exposure to BD, in the range of 1-3 ppm, may be associated with adverse biological effects.
Intravascular ultrasound versus angiography-guided stent implantation: Acute and long-term outcome in 2,883 patients Alexandre Abizaid, George Dangas, Andrea S. Abizaid, Roxana Mehran, Manuela Negoita, Cristian Cioara, Rajshkar Narasimaiah, Augusto D. Pichard, Alexandra J. Lansky, Gregg W. Stone, Gary S. Mintz, Martin B. Leon. Cardiovascular Research Foundation, New York, NM, Washington Heart Center, Washington, DC
Journal: Journal of the American College of Cardiology (2001)
Stable bubbles signal better breathing in neonate
Authors: J. Henahan
Journal: JAMA (1983)

Because they lack surfactants, the alveoli of the immature fetal lung cannot form the stable bubbles that are required for normal breathing after birth, says Emile M. Scarpelli, MD, professor of pediatrics, physiology, and biophysics at Albert Einstein College of Medicine, Bronx, NY. Scarpelli's report was presented at the recent International Symposium on the Surfactant System of the Lung held in Rome. "At the onset of breathing, high concentrations of surfactants in the normal fetal lung permit that lung to form stable bubbles that establish themselves as tiny air pockets in the alveolar spaces," Scarpelli told<i>JAMA</i>MEDICAL NEWS. "Before that, these spaces are filled with liquid, so that with the first breath, the alveolus makes a transition from the liquid-filled to the air-filled state." To prove that these bubbles—only 40 to 200 μm in diameter—exist in the mature but not the immature fetal lung, Scarpelli and associates used an
Primary therapy for Cushing's disease with metyrapone
Authors: G. Dickstein
Journal: JAMA (1986)

A 13-year-old boy was diagnosed as suffering from pituitary-dependent Cushing's syndrome. He was treated with 2.0 g of metyrapone daily as the sole treatment for four years. All clinical and biochemical stigmata of Cushing's disease disappeared within a few months. The patient grew 23.0 cm in four years and regained normal health. No significant side effects of metyrapone were noticed. Administering the medication at 2 PM and 8 PM allowed higher cortisol levels in the morning and noon hours than in the evening and night, approximating the normal diurnal variation in cortisol production. We conclude that metyrapone may be considered the sole treatment in patients with Cushing's disease. (<i>JAMA</i>1986;255:1167-1169)
Empire State Building Turns Pink in Support of Breast Cancer Research
Journal: JNCI Journal of the National Cancer Institute (1994)

Empire State Building Turns Pink in Support of Breast Cancer Research Get access JNCI: Journal of the National Cancer Institute, Volume 86, Issue 20, 19 October 1994, Page 1499, https://doi.org/10.1093/jnci/86.20.1499 Published: 19 October 1994
MEDICAL PESSIMISM.
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ineffectiveness of isoproterenol in shock due to acute myocardial infarction
Authors: R. M. Gunnar
Journal: JAMA (1967)

Studies of clinical and hemodynamic changes in 13 patients with shock due to acute myocardial infarction were conducted. Both levarterenol (norepinephrine) bitartrate and isoproterenol hydrochloride were infused, and the clinical and hemodynamic effects were compared. Arterial pressure could be increased to nearly normal levels in all patients when levarterenol was infused, and this drug appeared to contribute to recovery in four patients. Adequate arterial pressure was obtained in only one patient during isoproterenol infusion, and clinical deterioration was coincident with the change from levarterenol to isoproterenol infusion in four patients. Increases in cardiac output occurred with both drugs, but was related to clinical improvement only when this increase was associated with an elevation in mean arterial pressure. Maintenance of an adequate arterial perfusion pressure is essential in treating shock due to acute myocardial infarction. In most patients, levarterenol is superior to isoproterenol in achieving this goal.