15-Year Benefits of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality
Authors: Hermann Brenner, Thomas Heisser, Rafael Cardoso, Michael Hoffmeister
Journal: Annals of Internal Medicine (2023)

LettersJune 202315-Year Benefits of Sigmoidoscopy Screening on Colorectal Cancer Incidence and MortalityHermann Brenner, MD, MPH, Thomas Heisser, PhD, Rafael Cardoso, PhD, Michael Hoffmeister, PhD, MScHermann Brenner, MD, MPHDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany, Thomas Heisser, PhDDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany, Rafael Cardoso, PhDDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany, Michael Hoffmeister, PhD, MScDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, GermanyAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L23-0024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR: Juul and colleagues (1) provide the most comprehensive analysis to date on the effects of offering flexible sigmoidoscopy on colorectal cancer (CRC) incidence and mortality. Their pooled analysis of 15-year follow-up data from 4 large randomized controlled trials convincingly shows substantial and sustained reduction in both CRC cases and deaths. In intention-to-screen analyses, incidence reduction of any CRC and distal CRC was reported as 21% and 32%, respectively.However, the reported reduction refers to detected CRC cases rather than truly incident ones. The CRC detection rate was higher in the intervention group than in the usual care ...References1. Juul FE, Cross AJ, Schoen RE, et al. 15-year benefits of sigmoidoscopy screening on colorectal cancer incidence and mortality. A pooled analysis of randomized trials. Ann Intern Med. 2022;175:1525-1533. [PMID: 36215714] doi:10.7326/M22-0835 LinkGoogle Scholar2. Launoy G, Smith TC, Duffy SW, et al. Colorectal cancer mass-screening: estimation of faecal occult blood test sensitivity, taking into account cancer mean sojourn time. Int J Cancer. 1997;73:220-4. [PMID: 9335446] CrossrefMedlineGoogle Scholar3. Brenner H, Altenhofen L, Katalinic A, et al. Sojourn time of preclinical colorectal cancer by sex and age: estimates from the German national screening colonoscopy database. Am J Epidemiol. 2011;174:1140-6. [PMID: 21984657] doi:10.1093/aje/kwr188 CrossrefMedlineGoogle Scholar4. Sung NY, Jun JK, Kim YN, et al. Estimating age group-dependent sensitivity and mean sojourn time in colorectal cancer screening. J Med Screen. 2019;26:19-25. [PMID: 30261804] doi:10.1177/0969141318790775 CrossrefMedlineGoogle Scholar5. Brenner H, Stock C, Hoffmeister M. Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: systematic review and meta-analysis of randomised controlled trials and observational studies. BMJ. 2014;348:g2467. [PMID: 24922745] doi:10.1136/bmj.g2467 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Hermann Brenner, MD, MPH; Thomas Heisser, PhD; Rafael Cardoso, PhD; Michael Hoffmeister, PhD, MScAffiliations: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, GermanyDisclosures: Authors have reported no disclosures of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L23-0024. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee Also15-Year Benefits of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality Frederik E. Juul , Amanda J. Cross , Robert E. Schoen , Carlo Senore , Paul Pinsky , Eric Miller , Nereo Segnan , Kate Wooldrage , Paulina Wieszczy-Szczepanik , Paola Armaroli , Kjetil K. Garborg , Hans-Olov Adami , Geir Hoff , Mette Kalager , Michael Bretthauer , Magnus Løberg , and Øyvind Holme 15-Year Benefits of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality Frederik E. Juul , Amanda J. Cross , Paul Pinsky , Carlo Senore , Magnus Løberg Metrics June 2023Volume 176, Issue 6KeywordsCancer screeningColorectal cancerFlexible sigmoidoscopy ePublished: 20 June 2023 Issue Published: June 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...