tbuckley/cabot-search huggingface dataset:
Highlights of This Issue
Journal: Clinical Cancer Research (2016)

Oncolytic Virus Therapy in Conjunction with BortezomibYoo and colleagues investigated the impact of bortezomib, a peptide-based reversible proteasome inhibitor, combined with oncolytic herpes simplex virus-1 on glioblastoma cell death and sensitivity to NK cell immunotherapy in vitro and in vivo.The authors show that combination treatment induced inflammatory necroptotic cell death and the secretion of inflammatory cytokines into the tumor microenvironment.This resulted in enhanced NK cell activation and increased NK cell-mediated killing of infected tumor cells.These findings provide the rationale for combination therapy for glioblastoma.
Interferon Therapy for Chronic Viral Hepatitis
Authors: Adrian M. Di Bisceglie
Journal: New England Journal of Medicine (1994)

Over the past five years, the Journal has published the results of several controlled trials of interferon alfa in the treatment of chronic viral hepatitis. The first three concerned hepatitis C1,2 and hepatitis B3; interferon alfa is now widely used for the treatment of these common diseases. In this issue, Farci and her colleagues report on the use of interferon alfa to treat chronic hepatitis D4. They note that 50 percent of the patients in their study who were treated with high doses of interferon (9 million units three times weekly) had a complete response, as defined . . .
Clostridium perfringens Empyema Unresponsive to Penicillin
Authors: Daniel E. Silpa
Journal: JAMA (1982)

EMPYEMA caused by<i>Clostridium perfringens</i>is a rare infection that usually can be cured by penicillin therapy and drainage.<sup>1,2</sup>We describe a patient with clostridial empyema that was unusual because the organism was unresponsive to penicillin therapy. <h3>Report of a Case</h3> A 49-year-old man with severe peripheral arterial disease of the legs was admitted because of heart failure due to alcoholrelated congestive cardiomyopathy. Pulses were not palpable in his right leg, and a 2×3-cm ulcer was present on his right foot. Initial chest roentgenogram showed cardiomegaly and pulmonary edema. Although his condition improved on digoxin, furosemide, and hydralazine hydrochloride, he experienced a temperature of 37.7 °C and mild mental confusion. His WBC count was 22,000/cu mm, with a differential cell count of 90% polymorphonuclear leukocytes and 2% band cells. Lumbar puncture studies gave normal results. A chest roentgenogram on the seventh hospital day showed a loculated right pleural effusion.
Dislocations and Joint-Fractures.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Development of a Heroin-Addiction Treatment Program
Authors: Robert L. DuPont
Journal: JAMA (1971)

When the First National Conference on Methadone Treatment was held in 1968, the "crime capital of the nation," Washington, DC, had only a handful of heroin addicts participating in one treatment program. This program, called DATRC, was an outpatient abstinence program funded by the Office of Economic Opportunity and operated by the Department of Public Health. A few months later, the Senate District of Columbia Committee dramatized the growing problems of crime and heroin addiction in the nation's capital. The committee concluded that both law enforcement and treatment efforts were failing.<sup>1</sup>During the hearing, a study from the District of Columbia Department of Corrections was reviewed which demonstrated that the rate of commitment of known heroin addicts to the jail had risen gradually from about 50 to 150 cases a year from 1958 through 1966. Beginning in 1967, however, there was an exponential rise to 450 cases in 1968
Mechanisms of Immunologic Eradication of a Syngeneic Guinea Pig Tumor. I. Quantitative Analysis of Adoptive Immunity&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: Suyu Shu
 4, James T. Hunter, Herbert J. Rapp, Leila S. Fonseca
Journal: JNCI Journal of the National Cancer Institute (1982)

Adoptive immunity against a syngeneic hepatoma (line-10) of Sewall-Wright inbred strain 2 guinea pigs was analyzed by a two-dimensional titration of iv transferred immune lymphoid cells versus intradermal tumor challenges. Tumor resistance increased exponentially as a function of the number of immune lymphoid cells transferred. Within the tumor challenge doses analyzed, suppression of tumor growth mediated by the transferred immune lymphoid cells appeared to be independent of the primary immune response in the recipient. Quantitatively, rejection of a given number of tumor cells reflected the number of transferred immune cells and was independent of the presence of the same tumor at other skin sites. There was no evidence indicating that transferred immune cells were attracted specifically to the tumor inoculation site. The number of tumor cells that could be rejected at a skin site by adoptive immunity was greater than the estimated number of immune lymphoid cells present at the challenge site.
Immunoglobulins In Brucellosis
Authors: Seymour Herschberg
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Spink, in replying to a question (<b>217</b>:219, 1971) indicates that the presence of 7S immunoglobulins denotes active brucellosis. This is contrary to most studies on production of immunoglobulins in infectious states. McCullough<sup>1</sup>indicates that 19S (IgM) immunoglobulins appear first followed by 7S (IgG) immunoglobulins. McCullough<sup>1</sup>equates IgM with 19S and IgG with 7S. This is generally true. However, on occasion, IgM antibodies may be found in other than the 19S component. Does Spink mean that the 7S antibodies are IgM, or were the designations 7S and 19S reversed?
Awards, Appointments, Announcements
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Awards, Appointments, Announcements Get access JNCI: Journal of the National Cancer Institute, Volume 85, Issue 21, 3 November 1993, Pages 1721–1722, https://doi.org/10.1093/jnci/85.21.1721 Published: 03 November 1993
Surgical Applied Anatomy.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Scanning Malignant Neoplasms With Gallium 67
Authors: C. Lowell Edwards
Journal: JAMA (1970)

Gallium has an affinity for some human as well as animal neoplasms. Carrier-free gallium citrate Ga 67 administered intravenously is localized in a variety of malignant tumors that can then be detected on scintiscans. Nonosseous as well as skeletal lesions can be seen, including some that are not otherwise detectable. No untoward effects were observed in 41 patients studied. Scans were abnormal in 23 patients with a variety of malignant neoplasms; reticulum cell sarcoma, lymphoblastoma, and poorly differentiated adenocarcinoma gave the most consistent results. The 18 patients in whom scans were normal included three patients with plasma cell myeloma, four with lymphocytoma, and five with Hodgkin's disease involving small retroperitoneal nodes. Gallium localization is greatest in viable tumor, less in fibrotic or necrotic tumor, and diminished by irradiation and effective chemotherapy. The mechanism is unknown.
Development and Preliminary Clinical Evaluation of a Peptide Immunotherapy Vaccine for Cat Allergy
Authors: M. Larché, H. Lee, J. Kleine-Tebbe, R.P. Hafner, P. Laidler, D. Healey, C. Buhot, A. Verhoef, B. Maillère, A.B. Kay
Journal: Journal of Allergy and Clinical Immunology (2011)
Percutaneous absorption of hydrocortisone and testosterone on the vulva and forearm: effect of the menopause and site
Authors: H.A. ORIBA, D.A.W. BUCKS, H.I. MAIBACH
Journal: British Journal of Dermatology (1996)

Summary The percutaneous absorption of hydrocortisone and testosterone was studied following their application to the vulvar and ventral forearm regions of pre- and post-menopausal women. Percutaneous absorption of hydrocortisone was significantly greater in vulvar skin than forearm skin in both pre- and post-menopausal women (P <0·05. respectively), whereas the percutaneous absorption of testosterone was significantly increased (P<0·01) on the vulva compared with the arm only in post-menopausal women. The effect of age on the percutaneous absorption of hydrocortisone and testosterone was evaluated by using the menopause as a biological chronometric end point. It is a common misconception that older skin has a diminished barrier capacity, and that percutaneous absorption is therefore greater. Our studies showed that absorption of hydrocortisone vulval skin of pre-menopatisal women was significantly greater (P<0·01) than in post-menopausal women. The ventral forearm skin of pre-menopausal women tended to show increased absorption compared with post-menopausal women, but statistical significance was not reached. No significant differences (P > 0· 05) in the percutaneous absorption of testosterone in vulval or forearm skin were observed between the two age groups.
Interhospital Transfer of Acutely Ill Cardiac Patients
Authors: Richard O. Cummins
Journal: JAMA (1988)

Complex issues arise whenever the topic of patient transfer is examined. These include the clinical indications for transfer,<sup>1,2</sup>whether the transfer produced adverse clinical effects,<sup>3</sup>and patient stabilization before transfer.<sup>4</sup>There are also questions about the professional level of the transfer personnel<sup>5</sup>and, in this era of burgeoning aeromedical services, about the best mode of transport.<sup>6</sup>In addition, the subject evokes concern over preferential transfer of financially undesirable patients<sup>7-10</sup>and the regionalization of health care resources.<sup>11,12</sup> See also p 1695. In this issue ofTHE JOURNAL, Rubenstein et al<sup>13</sup>present a descriptive study that is useful, even though it sidesteps some of these issues. The article describes 755 acutely ill cardiac patients who were successfully transferred from any of seven Kaiser Permanente medical facilities to a tertiary medical center in Los Angeles. A large majority (96%) of the patients were accompanied only
Experimental retinoid effective in treatment of severe acne
Authors: Phil Gunby
Journal: JAMA (1980)

Experimental use of the oral agent isotretinoin (13-cis-retinoic acid) has produced extensive remissions of cystic and conglobate acne so far in two series, totaling 47 patients. Less clear are the drug's effects on various keratinizing dermatoses and basal cell carcinomas. The retinoids, a family of compounds that includes both synthetic and natural forms of vitamin A, appear to have effects on cell maturation and differentiation. Because of this, isotretinoin is being used also in a clinical chemoprevention trial with volunteers who are at high risk for bladder cancer (<i>JAMA</i>[MEDICAL NEWS] 240:609-610, 614-615, 1978). During the American Academy of Dermatology's annual meeting in Chicago, some results to date in the cutaneous trials were discussed by Gary L. Peck, MD, senior investigator, Dermatology Branch, National Cancer Institute (NCI), Bethesda, Md, and Dorothy B. Windhorst, MD, director of clinical research for dermatology, Hoffmann-La Roche Inc, Nutley, NJ. Peck said that the antibiotic-resistant
Salicylate Exposure in the Perinate
Authors: Paul A. Palmisano
Journal: JAMA (1969)

Recent studies demonstrating the presence of salicyluric acid in neonatal urine specimens have suggested intrauterine fetal exposure to aspirin or other salicylates. Umbilical cord sera from 272 consecutively delivered infants were examined for salicylate. Unexpectedly, salicylate levels were above 1 mg/100 ml in 26 of the sera (9.5%). The degree of fetal exposure to salicylate was indicated by a mean concentration of 3.3 mg/100 ml with a range of 1.2 to 10.9 mg/100 ml in this group. The mean reserve albumin binding capacity for these sera was significantly depressed. Unrecognized fetal exposure to salicylate is surprisingly common during late pregnancy.
Use of Fluoresceinated Complement-Coated Bacteria and Sheep Erythrocyte-Antibody-Complement Complexes for Identification of Complement Receptors on Lymphoid Cell Lines: Differences in Binding Characteristics Between Cell Lines of Normal and Malignant Origin
Authors: Benjamin, David, Magrath, Ian T., Freeman, Charles B.
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Use of Fluoresceinated Complement-Coated Bacteria and Sheep Erythrocyte-Antibody-Complement Complexes for Identification of Complement Receptors on Lymphoid Cell Lines: Differences in Binding Characteristics Between Cell Lines of Normal and Malignant Origin Get access David Benjamin, David Benjamin 3 3Address reprint requests to Dr. Benjamin, Building 10, Room 13N240, National Institutes of Health, Bethesda, Md. 20205. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ian T. Magrath, Ian T. Magrath Search for other works by this author on: Oxford Academic PubMed Google Scholar Charles B. Freeman Charles B. Freeman Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 71, Issue 5, November 1983, Pages 897–902, https://doi.org/10.1093/jnci/71.5.897 Published: 01 November 1983 Article history Received: 09 November 1982 Revision received: 06 June 1983 Accepted: 20 June 1983 Published: 01 November 1983
Preventive Oncology: An Opportunity for Clinical Cancer Centers
Authors: Ernst L. Wynder, M.D.
Journal: JNCI Journal of the National Cancer Institute (1984)

Journal Article Preventive Oncology: An Opportunity for Clinical Cancer Centers Get access Ernst L. Wynder, M.D. Ernst L. Wynder, M.D. American Health FoundationNew York, New York 10017 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 72, Issue 2, February 1984, Pages 201–202, https://doi.org/10.1093/jnci/72.2.201 Published: 01 February 1984
The International Responsibilities of American Medical Education
Authors: Carlos J. M. Martini
Journal: JAMA (1987)

THE FIRST medical college in America was established in New York City in 1765 by its two-man faculty, John Morgan, MD, and William Shippen, Jr, MD, who had trained in Scotland. Samuel Bard, MD, a graduate of Edinburgh, Scotland, established the second medical school, also in New York, in 1767.<sup>1</sup>However, for more than 100 years subsequent to development of our first schools, American physicians were still training in large numbers in Europe, in particular in England and Germany. The United States has continued to import medical professionals; at present, more than one fifth of all the physicians in this country are foreign medical graduates. Our need for foreign-trained medical physicians, or even American-educated physicians, has now changed dramatically, with a possible excess of supply. Numerous voices have been raised recently with different proposals to share our qualified health manpower and academic programs with the rest of the world.
The British Society of Gastroenterology
Authors: R Walt, J Rawlings, R Hunt, L Golding, G Milton- Thompson, J Misiewicz, J Saunders, A Wodak, A Haines, M Davis, Roger Williams
Journal: Gut (1980)

and Royal Naval Hospital, Haslar) Cimeti- dine is an effective treatment for duodenal ulcer (DU).The new histamine H2- receptor antagonist ranitidine effectively inhibits 24 h H + activity when given twice-daily.We compared ranitidine 150 mg bd with cimetidine 200 mg tds, 400 mg nocte in healing of duodenal ulcers treated for four weeks and assessed endoscopically.At three centres 98 patients were randomly allocated to two treatment groups, the endoscopists being unaware of the treatment.Concomitant serious illness, pyloric stenosis, pyloric ulceration, anti-inflammatory therapy, and previous gastric surgery were ex- cluded.All ulcer treatments had been discontinued at least one month pre- viously.There were no significant dif- ferences in age and sex matching between treatment groups both within and be- A897 on August 30,
Effect of Subcutaneous Tunneling on Internal Jugular Catheter-Related Sepsis in Critically III Patients
Authors: Jean-François Timsit
Journal: JAMA (1996)

<h3>Objective.</h3> —To evaluate the effect of catheter tunneling on internal jugular catheter-related sepsis in critically ill patients. <h3>Design.</h3> —A prospective randomized controlled study involving 3 intensive care units (ICUs), stratified by number of catheter lumina (1 or 2) and center. <h3>Setting.</h3> —The 10-bed medical-surgical and 10-bed surgical ICUs at Saint Joseph Hospital and 8-bed surgical ICU at Clinique de la Défense, Paris, France. <h3>Patients.</h3> —Every patient older than 18 years admitted to the ICUs between March 1,1993, and July 17,1996, who required a jugular venous catheter for more than 48 hours. <h3>Intervention.</h3> —Random allocation to tunneled or nontunneled catheters. <h3>Measurements.</h3> —Times to occurrence of systemic catheter-related sepsis, catheter-related septicemia, or a quantitative catheter-tip culture with a cutoff of 103 colony-forming units per milliliter. <h3>Results.</h3> —A total of 241 patients were randomized. Ten patients in whom jugular puncture was not achieved were subsequently excluded. The proportion of patients receiving mechanical ventilation (87%) and mean±SD age (65±4 years), Simplified Acute Physiologic Score (13.3±4.9), Organ System Failure score (1.5±1.0), and duration of catheterization (8.7±5.0 days) were similar in both groups. Taking into account the first 231 catheters (114 nontunneled [control], 117 tunneled), we found that tunnelization decreased catheter-related sepsis (odds ratio [OR], 0.33; 95% confidence interval [CI], 0.13-0.83; P=.02), catheter-related septicemia (OR, 0.23; 95% CI, 0.07-0.81; P=.02), and, though not statistically significant, positive quantitative tip-culture rate (OR, 0.62; 95% CI, 0.35-1.10; P=.10). These results were slightly modified after adjustment on parameters either imbalanced between both groups (duration of catheter placement and cancer at admission) or prognostic (insertion by a resident, use of antibiotics at catheter insertion, cancer, and sex). <h3>Conclusion.</h3> —The incidence of internal jugular catheter-related infections in critically ill patients can be reduced by using subcutaneous tunnelization.
Weight Reduction With Low-Calorie Diets
Authors: Ernst J. Drenick
Journal: JAMA (1967)

Some of the reasons why so many severely obese patients fail to reach normal weight with moderate dietary restriction are the disappointingly slow weight loss and persistent hunger. Consequently, many physicians have been resorting to dietary regimens supplying 200 to 600 calories. The result is rapid and extensive weight loss without much hunger. The purpose of this communication is to emphasize the advantages of a "semistarvation" regimen and to suggest some measures which enhance the chances of success while minimizing the hazards inherent in such treatment. Severe dietary restriction does result in major physical and biochemical changes, and these can, in certain patients, cause serious complications. <h3>Patient Selection.—</h3> Most patients with uncomplicated obesity will easily tolerate prolonged semistarvation. Children and adolescents who are still growing and pregnant women should be excluded because of possible impairment of growth. In the older-age group, the risk of complications would seem to be excessive
Pacific Basin May Provide Early Flu Warning
Authors: Charles Marwick
Journal: JAMA (1989)

NATIONS around the Pacific Ocean are enlisting to track emerging variant influenza viruses so vaccines can be prepared in time for future epidemics. Alan Kendal, PhD, influenza branch chief, Centers for Disease Control, Atlanta, Ga, says this "Pacific Basin Respiratory Virus Research Group" has participants so far from Australia, New Zealand, Japan, China, Hong Kong, Thailand, Malaysia, Papua New Guinea, Fiji, United States (Hawaii), Chile, and Panama. A system is being set up to obtain and report more rapidly (perhaps weekly) on specimens tested and viruses isolated, comparable with the surveillance system in the United States. He points out that there have been several years when influenza viruses have appeared in the United States without warning. He cites appearances of A/Taiwan/86, A/Chile/83, and—last year—A/Sichuan. "Those viruses were first detected in the Pacific region and within 6 to 9 months they were causing outbreaks and epidemics in the United States," he