tbuckley/cabot-search huggingface dataset:
Health Care Reform in Minnesota
Authors: Steven H. Miles, Nicole Lurie, Lois Quam, Arthur Caplan
Journal: New England Journal of Medicine (1992)

On April 23, Minnesota enacted complex and far-reaching legislation to reform health care.1 The goals of the law are to contain costs and ensure that all Minnesotans have affordable insurance for basic outpatient and inpatient health care. Its major provisions reform health insurance practices, establish a state-subsidized, sliding-scale health insurance plan, provide for regional planning of the health care system, support endangered systems of rural health care delivery, decrease the need for defensive medical practices, establish a data base on the provision and outcome of health care, and propose to consolidate the state's health care bureaucracy.BackgroundIn 1989 increasing . . .
Comparison of twitch force and calcium handling in papillary muscles from right ventricular pressure overload hypertrophy in weanling and juvenile ferrets
Authors: J. K Gwathmey, R. Liao, J. S Ingwall
Journal: Cardiovascular Research (1995)

Journal Article Comparison of twitch force and calcium handling in papillary muscles from right ventricular pressure overload hypertrophy in weanling and juvenile ferrets Get access Judith K Gwathmey, Judith K Gwathmey * aHarvard Medical School Cardiovascular Diseases and Muscle Research Laboratories, 220 Longwood Avenue, Building B-1, Room 146, Boston, MA 02115, USA *Correspondence to Dr Gwathmey. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ronligh Liao, Ronligh Liao aHarvard Medical School Cardiovascular Diseases and Muscle Research Laboratories, 220 Longwood Avenue, Building B-1, Room 146, Boston, MA 02115, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Joanne S Ingwall Joanne S Ingwall bDepartment of Medicine, Brigham and Women's Hospital, Boston, MA, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 29, Issue 4, April 1995, Pages 475–481, https://doi.org/10.1016/S0008-6363(96)88522-1 Published: 01 April 1995 Article history Received: 15 August 1994 Accepted: 24 October 1994 Published: 01 April 1995
CONTACT DERMATITIS XXII
Authors: Reinhard Breit, Hans-Jürgen Bandmann
Journal: British Journal of Dermatology (2006)

Journal Article CONTACT DERMATITIS XXII: Dermatitis from lanolin Get access Reinhard Breit, Reinhard Breit Dermatologische Klinik und Poliklinik der Universität, D‐8 München 2, Frauenlobstrasse 9, West Germany Search for other works by this author on: Oxford Academic Google Scholar Hans‐Jürgen Bandmann Hans‐Jürgen Bandmann Dermatologische Klinik und Poliklinik der Universität, D‐8 München 2, Frauenlobstrasse 9, West Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 88, Issue 4, 1 April 1973, Pages 414–416, https://doi.org/10.1111/j.1365-2133.1973.tb07577.x Published: 01 April 1973
Prosthetic Valve Endocarditis Caused by Histoplasma capsulatum
Authors: W. James Alexander
Journal: JAMA (1979)

HISTOPLASMA<i>capsulatum</i>is a rare cause of infective endocarditis. Three patients have previously been described with postoperative histoplasma endocarditis.<sup>1-3</sup>We describe here a patient with prosthetic valve endocarditis (PVE) and chronic meningitis caused by<i>H capsulatum</i>. This organism should be considered in the evaluation of patients with intracardiac prostheses, fever, and negative blood cultures. <h3>Report of a Case</h3> In January 1972, a 37-year-old man had a stenotic aortic valve replaced by a homograft. In September 1975, he noted dyspnea on exertion, and aortic regurgitation was detected. Diuretics and digitalis were prescribed, but heart failure worsened. On March 23, 1976, the defective homograft was replaced at our hospital by a Bjork-Shiley aortic prosthesis. The excised hemograft showed only fibrosis and calcification. The patient did well until July 1976, when fever and weight loss were noted, followed by right hemiparesis and aphasia. He was admitted to another hospital, where CSF was
Diagnosis of Rabies by Immunofluorescence in Trypsin-Treated Histologic Sections
Authors: Kenneth P. Johnson
Journal: JAMA (1980)

After trypsin digestion of 4% formaldehyde (10% formalin)-fixed, paraffin-embedded brain sections, immunofluorescence identification of rabies antigen was successful in three human rabies cases and in experimentally infected mice. The method allows better interpretation of the anatomic localization of rabies antigen and will be helpful in studies of the pathogenesis of rabies. It will also be diagnostically useful where fresh or fresh-frozen brain tissue is not available, although it should not be considered as a replacement for standard immunofluorescence and mouse inoculation techniques for rabies diagnosis. (<i>JAMA</i>244:41-43, 1980)
Highlights of This Issue
Journal: Clinical Cancer Research (2010)

To explore the prevalence of defective homologous recombination (HR)-based DNA repair in sporadic cancers, Graeser and colleagues assessed RAD51 in breast cancer biopsies taken 24 hours after chemotherapy. They found that defective HR was highly prevalent in triple-negative breast cancer and that it was also present in other breast cancer subtypes at lower frequency. Defective HR was strongly associated with pathologic complete response to chemotherapy. However, the majority of HR-defective cancers did not achieve a complete response, identifying cancers that may benefit from treatments that target defective HR (such as PARP inhibitors).The targeted therapy revolution has brought with it high expectations, however, due to the complexity of cancer, progress has been slow. In this issue of CCR Focus, guest editors LoRusso, Wolf, Averbuch, and Schnipper discuss the challenges of obtaining meaningful improvements in cancer outcomes. Topics discussed include difficulties in determining the true clinical benefit of drugs and which patient subgroups will benefit (or be harmed), improving randomized controlled trial design and efficiency of the investigational pipeline, the high costs of drugs that provide marginal benefit in unselected populations, and the need for health care reform that supports clinical trials.The generation of autologous tumor-reactive tumor-infiltrating lymphocytes (TIL) for individual patients is difficult and can impede adoptive cell therapy (ACT). Here, Dudley and colleagues used a simplified method to generate TIL for effective ACT. Fifty-six patients with advanced melanoma, most refractory to standard treatments, received CD8+ enriched young TIL; thirty patients (54%) had an objective response, including five complete responders. The use of CD8+ enriched young TIL may enable potent cell therapies to reach additional melanoma patients and this approach could be extended to patients with other solid malignancies.Notch activity is important in many tumors types and Notch pathway inhibitors are beginning to enter clinical trials. Here, Schreck and colleagues found that Notch blockade in glioblastoma neurospheres resulted in the upregulation of two other pathways commonly activated in cancer stem cells, Hedgehog and Wnt. Further, simultaneous inhibition of Notch and Hedgehog increased therapeutic efficacy. The Notch target Hes 1 was shown to bind the locus encoding the Hedgehog pathway member Gli 1, providing a potential direct mechanism for crosstalk. These data suggest that it may be necessary to simultaneously target multiple developmental signaling pathways to prevent the emergence of therapeutic resistance.
A Text-Book of Physiology for Medical Students and Physicians.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Firearm Injury Reporting System Revisited
Authors: Stephen P. Teret
Journal: JAMA (1996)

Debates on gun policy are vitriolic. Each side of the issue feels that current policy is flawed or inadequate, and consequently, the direction in which policy should move is hotly contested. Every suggestion to alter gun policy, whether the suggestion is seen as pro-gun or anti-gun, is met by its opponents with the specter of disaster. Often, it seems that there is no opportunity for agreement among those debating the issues surrounding gun policy. This especially appears to be the case when disagreement includes the basic premises on which policy would be built. However, despite fundamental differences in their viewpoints, both pro-gun and anti-gun proponents support the need for additional data and improved data collection.<sup>1</sup>Perhaps this rare agreement can be seized on for the benefit of all. See also p 42. In 1992,The Journalcarried the message that a national system for the collection of data on
Hematuria and Leukemic Bladder Infiltration
Authors: Ann M. Grooms
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Hematuria is not an unusual finding in acute leukemia of childhood. Diffuse or localized bladder infiltration as a cause of hematuria is apparently uncommon. A child came to the Medical University Hospital on two occasions with hematuria that responded to irradiation therapy and apparently represented leukemic bladder infiltration. <h3>Report of a Case.—</h3> A 7-year-old white boy was found to have acute lymphoblastic leukemia in June 1970. Remission induction was accomplished with vincristine sulfate and prednisone, and he was maintained with cyclic chemotherapy. In April 1971, central nervous system (CNS) leukemia developed that was successfully treated with intrathecal methotrexate. Ten days later, painless gross hematuria appeared and persisted for three weeks, at which time investigative studies were begun. The patient had not received cyclophosphamide for one month prior to the onset of hematuria. The hemoglobin level was 8.5 gm/100 ml; white blood cell count (WBC) was 3,600/cu mm
Current Medical Literature
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coffee Drinking Prior to Acute Myocardial Infarction
Authors: Arthur L. Klatsky
Journal: JAMA (1973)

No independent association between coffee drinking and a subsequent first myocardial infarction in 464 patients was found in a study well controlled for cigarette smoking and five other established "risk factors." Coffee drinking and cigarette smoking are strongly correlated habits. Review of other studies of coffee and coronary heart disease indicates that discrepancies in findings may be related either to cigarette smoking or to selection of control subjects. Coffee drinking is not an established risk factor for myocardial infarction.
Studies of Malabsorption and Calcium Excretion Induced by Neomycin Sulfate
Authors: Stephen J. Gordon
Journal: JAMA (1968)

In studies of the mechanism of neomycin sulfate-induced malabsorption, this drug was administered orally and by tube to the jejunum and ileum in 11 subjects. Studies of fat, calcium, sodium, potassium, and nitrogen excretion were carried out in both urine and feces. Reduction in the steatorrhea was produced by the progressively more distal placement of neomycin. Fecal sodium, potassium, and nitrogen levels were less affected by the site of antibiotic delivery, but the fecal calcium content was greatest with jejunal instillation. Divergence between changes in fecal fat and calcium levels was observed consistently. Urinary calcium, sodium, and potassium levels were frequently greater when neomycin was delivered into the jejunum or ileum than when it was given orally. The administration of bile salts, sodium bicarbonate, and pancreatic enzymes did not consistently affect the steatorrhea.
2,4-Dichlorophenoxyacetic Acid Poisoning in Man
Authors: Philip Berwick
Journal: JAMA (1970)

A man who accidentally ingested 2,4-dichlorophenoxyacetic acid (2,4-D) exhibited fibrillary twitching and paralysis of intercostal muscles. There was evidence of generalized skeletal muscle damage as indicated by marked elevation of serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, lactic dehydrogenase, aldolase, and creatine phosphokinase levels. In addition to hemoglobinuria, myoglobinuria (to our knowledge, previously unreported in this condition) was observed.
Letting intrauterine devices lie
Authors: A E Capewell, S A Bober, V Wadehra, C Kumar, J E Hickman, H R Ingham
Journal: BMJ (1982)

in the first 12 months,7 a comparison of the curves beginning after year 1 may be con- founded by variables related to survival.A number of presumably high-risk patients in the beta-blocker group were saved in the first year, most probably resulting in a patient population on that treatment which was, on average, sicker than that on placebo after one year.Thus, parallel and even converging curves beyond one year could be consistent with continued benefit.In addition, we do not know what would happen if the treatment were stopped at one year.Rose9 has posed the question, "Do beta-blockers merely keep the wolf from the door, and when protection is withdrawn, does he retum ?"We tend to conclude from the absolute difference in the number of deaths between the beta-blocker and placebo groups at the end of a trial how many lives had been prolonged.The results from the Norwegian timolol trial could imply that 54 deaths (152 minus 98) were delayed by an average of at least 17 months.Another interpretation could be that more than 150 patients had their lives prolonged by an average of six months.We have no way of knowing with certainty over what period of time during the entire patient follow-up protection is provided-that is, when the door is closed on the wolf.For these reasons, it seems prudent to recommend beta-blocker treatment to survivors of a heart attack for at least three years, the duration of the trial7 which followed patients for the longest time.
Hemoglobin Regeneration in Severe Iron-Deficiency Anemia
Authors: Jack A. Pritchard
Journal: JAMA (1966)

Severe iron deficiency anemia can be corrected very nearly as fast by several inexpensive preparations of oral iron as by iron dextran injection or saccharated iron oxide. The average rate of increase in hemoglobin concentration in 28 women who ingested ferrous sulfate, ferrous gluconate, or ferrous fumarate in amounts which provided 180 to 220 mg of iron per day was 0.25 gm/ 100 ml/day compared to 0.28 gm/100 ml/day in 14 who received iron dextran injection intramuscularly and 0.33 gm/100 ml/day in 14 who were treated with saccharated iron oxide given by intravenous infusion. Ferrous sulfate, ferrous fumarate, or ferrous gluconate in a daily dose containing about 200 mg of iron are very satisfactory for treating most cases of severe iron deficiency anemia.
Abdominal Mass in a Child
Authors: A. Everette James
Journal: JAMA (1969)

Dr. Kook Sang Oh: This 6 1/2-year-old girl was referred to the Massachusetts General Hospital because of a mass on the right side of the abdomen. The patient was the product of an uneventful pregnancy and delivery and had been well until three months prior to admission. At that time, she began to experience intermittent vague low-back pain which awakened her from sleep and was aggravated by motion. One day before admission the patient was seen by her family physician who referred her to this hospital. At the time of physical examination the patient was in the 80th percentile for height and weight, her blood pressure was 150/90 mm Hg, and a large nontender immovable firm mass was palpated in the right side of her abdomen. The liver edge was separate from the mass; the liver was not enlarged. A phentolamine (Regitine) mesylate test was negative. Urinalysis was negative except
Brochure on Radioisotopes For the Patient
Authors: David J. Seff
Journal: JAMA (1970)

<h3>To the Editor.—</h3> The use of tracer radioisotopes has been instrumental in broadening the scope of medicine beyond the gross clinical and pathological methods to the spectrum of molecular biology. Although initially limited to university hospitals and research centers, nuclear medicine is now an indispensable department in the majority of hospitals in the United States. Consequently, the clinician has become sophisticated in the application of radioisotopes in his daily diagnostic practice. However, we have neglected our responsibility as physicians in educating the patient with respect to the safety and the innocuous nature of his radioactive exposure. As chief of the department of nuclear medicine at The Church Home and Hospital in Baltimore, I have been cognizant of the patient's fear of radioisotopes and of his complete ignorance of the significance and nature of the study for which he has been scheduled. Consequently, our department, which we feel is patient oriented,
The Physician and the Slave Trade: John Kirk, the Livingstone Expeditions, and the Crusade Against Slavery in East Africa
Authors: Eric Howard Christianson
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Kids Who Kill: Nature Plus (Lack of) Nurture
Authors: Lynne Lamberg
Journal: JAMA (1996)

A 6-YEAR-OLD Richmond, Calif, boy has been charged with attempted murder after allegedly dumping a neighbor's newborn baby out of its bassinet, pummeling it, kicking it, and perhaps beating it with a stick. The incident in April left the baby with a fractured skull, brain-damaged, and on life support. What should the system do with, about, and for this boy? Should society put children who kill in juvenile or adult prisons? Should it try to help them in some way? Are children becoming violent at a younger and younger age, or has media fascination with the topic simply created this impression? Elissa Benedek, MD, past president of the American Psychiatric Association (APA), invited 3 other psychiatrists, a prosecuting attorney, a defense attorney, and a judge to explore these questions at the recent annual APA meeting. Benedek directs research and training at the Center for Forensic Psychiatry at the University of
&lt;italic&gt;Brief Communication:&lt;/italic&gt; Tumor Initiation by &lt;italic&gt;N&lt;/italic&gt;-Acyloxy Derivatives of Piperidine and &lt;italic&gt;N&lt;/italic&gt;-Arylacetamides
Authors: John D. Scribner, Thomas J. Siaga
Journal: JNCI Journal of the National Cancer Institute (1975)

Four N-acetoxy-N-arylacetamides previously found to be local sarcomagens in the rat have been found to be initiators of tumorigenesis in mouse skin. The order of activity was: N-acetoxy-2-acetamidophenanthrene > N-acetoxy-4-acetamido-stilbene ≈ N-acetoxy-2-acetamidofluorene > N-acetoxy-4-acetamidobiphenyl. Two substituted N-benzoyloxypiperidines previously shown to yield nitrenium ions on solvolysis in methanol also had initiating activity in mouse skin.
Manual of Tropical Medicine.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal