tbuckley/cabot-search huggingface dataset:
An immunity and pyroptosis gene-pair signature predicts overall survival in acute myeloid leukemia
Authors: Weikaixin Kong, Liye He, Jie Zhu, Oscar Brück, Kimmo Porkka, Caroline A. Heckman, Sujie Zhu, Tero Aittokallio
Journal: Leukemia (2022)

Abstract Treatment responses of patients with acute myeloid leukemia (AML) are known to be heterogeneous, posing challenges for risk scoring and treatment stratification. In this retrospective multi-cohort study, we investigated whether combining pyroptosis- and immune-related genes improves prognostic classification of AML patients. Using a robust gene pairing approach, which effectively eliminates batch effects across heterogeneous patient cohorts and transcriptomic data, we developed an immunity and pyroptosis-related prognostic (IPRP) signature that consists of 15 genes. Using 5 AML cohorts ( n = 1327 patients total), we demonstrate that the IPRP score leads to more consistent and accurate survival prediction performance, compared with 10 existing signatures, and that IPRP scoring is widely applicable to various patient cohorts, treatment procedures and transcriptomic technologies. Compared to current standards for AML patient stratification, such as age or ELN2017 risk classification, we demonstrate an added prognostic value of the IPRP risk score for providing improved prediction of AML patients. Our web-tool implementation of the IPRP score and a simple 4-factor nomogram enables practical and robust risk scoring for AML patients. Even though developed for AML patients, our pan-cancer analyses demonstrate a wider application of the IPRP signature for prognostic prediction and analysis of tumor-immune interplay also in multiple solid tumors.
Fusion of Plasmacytoma and Host Cells In Vivo: Selection of Proliferating and Nonproliferating Cultures&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Rosalie Ber, Naomi Lanir
Journal: JNCI Journal of the National Cancer Institute (1984)

The double-mutant cell line 4T00.1 is derived from a plasmacytoma of a BALB/c mouse and is resistant to 6-thioguanine and ouabain. These cells were inoculated into (BALB/c × C57BL)F1 mice by different routes—sc, ip, intrasplenically, and intrathymically. The degree of tumorigenicity and pattern of tumor development were site-dependent. Intrasplenic inoculation of 103−104 4T00.1 cells resulted in development of large omental tumors accompanied by marked ascites. Tenfold to a thousandfold more 4T00.1 cells were required to obtain tumors by other routes. From all solid tumors and ascites and from various organs of tumor-bearing mice, which were explanted into culture in double selective medium containing hypoxanthine, aminopterin, and thymidine plus ouabain (in which only hybrids between 4T00.1 and normal cells can survive), proliferating and nonproliferating cultures were obtained. Of the 14 proliferating cultures, 9 proved to be hybrids by chromosome and H-2 isoantigen analyses and were tumorigenic when 106 cells were inoculated sc into syngeneic F1 mice.
Electrocardiographic Effects of Marihuana
Authors: Martin H. Wendkos
Journal: JAMA (1973)

<h3>To the Editor.—</h3> With respect to the results of their study, Kochar and Hosko (225:25, 1973) found that after high doses of Δ-9-tetrahydrocannabinol, there was a reduced amplitude of the T-wave associated with S-T elevation in subject 1; a flattening of the T-wave without S-T-segment change in subject 2; and an absence of T-wave change in the remaining five subjects. Moreover, from the reproductions of the electrocardiograms, it is possible to ascertain the nature of the changes in subject 1, which were those the authors had particularly considered a justification for their claim that marihuana may possess a cardiotoxic property. However, so far as I can judge, even though the race of the subject was not mentioned, the findings (equivalent persistent S-T elevations throughout and slight variations in the form of the T-wave) constitute characteristic traits of the "normal S-T variant."<sup>1</sup>The matter of race was introduced, because in
Venous Thromboembolic Disease in Uncemented Total Hip Replacement Surgery–a One-Year Follow-up of 490 Patients
Authors: P H Wittmann, F W Wittmann, P A Ring
Journal: Journal of the Royal Society of Medicine (1991)

A retrospective study of the morbidity and mortality from deep vein thrombosis (DVT) and pulmonary embolus (PE) in 490 consecutive patients undergoing uncemented total hip replacement was carried out in a district general hospital. Special diagnostic tests for DVT and PE were not available. Patients were followed up for one year. There were three deaths in hospital and eight further deaths during the first year, all unrelated to DVT and PE. The clinical incidence of venous thromboembolism was 2.04%. While clinical diagnosis of venous thromboembolic disease probably underestimates its incidence, the figures for mortality are accurate. With every patient accounted for one year after operation, there were no deaths attributable to PE in this series.
Synopsis of Diseases of the Heart and Arteries
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Emergencies, Second Opinions Are Not Mandatory
Authors: Richard F. Kunkle
Journal: JAMA (1985)

<h3>To the Editor.—Report of a Case.—</h3> On Jan 1, 1985, a 16-year-old girl arrived in our emergency department following a one-vehicle motorcycle accident. She was riding her motorcycle up a hill when she rolled the bike over a cliff; the bike landed on top of her. She was attended by a friend who stated she did not lose consciousness; however, she did complain of facial, chest, and abdominal pain. Upon arrival in the emergency room, she showed major facial lacerations and abdominal guarding, tenderness, and diminished bowel sounds. Maintenance of vital signs required crystalloid infusion. During the 20 to 30 minutes required to obtain surgical evaluation, the patient began demonstrating increased right upper quadrant tenderness and increasingly diffuse guarding and rigidity. When the parents were advised that surgery for suspected intra-abdominal bleeding was required, they stated that they had received notification that a second opinion and precertification of need was
Periodontitis-related salivary microbiota aggravates Alzheimer’s disease via gut-brain axis crosstalk
Authors: Jiangyue Lu, Shuang Zhang, Yuezhen Huang, Jun Qian, Baochun Tan, Xueshen Qian, Jia Zhuang, Xihong Zou, Yanfen Li, Fuhua Yan
Journal: Gut Microbes (2022)

The oral cavity is the initial chamber of digestive tract; the saliva swallowed daily contains an estimated 1.5 × 1012 oral bacteria. Increasing evidence indicates that periodontal pathogens and subsequent inflammatory responses to them contribute to the pathogenesis of Alzheimer's disease (AD). The intestine and central nervous system jointly engage in crosstalk; microbiota-mediated immunity significantly impacts AD via the gut-brain axis. However, the exact mechanism linking periodontitis to AD remains unclear. In this study, we explored the influence of periodontitis-related salivary microbiota on AD based on the gut-brain crosstalk in APPswe/PS1ΔE9 (PAP) transgenic mice. Saliva samples were collected from patients with periodontitis and healthy individuals. The salivary microbiota was gavaged into PAP mice for two months. Continuous gavage of periodontitis-related salivary microbiota in PAP mice impaired cognitive function and increased β-amyloid accumulation and neuroinflammation. Moreover, these AD-related pathologies were consistent with gut microbial dysbiosis, intestinal pro-inflammatory responses, intestinal barrier impairment, and subsequent exacerbation of systemic inflammation, suggesting that the periodontitis-related salivary microbiota may aggravate AD pathogenesis through crosstalk of the gut-brain axis. In this study, we demonstrated that periodontitis might participate in the pathogenesis of AD by swallowing salivary microbiota, verifying the role of periodontitis in AD progression and providing a novel perspective on the etiology and intervention strategies of AD.
Modern Obstetrics, General and Operative.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Practical Pathology, a Manual for Students and Practitioners.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Absorption of Orally Given Digoxin Preparations
Authors: David H. Huffman
Journal: JAMA (1972)

Digoxin absorption has been studied in four normal volunteers. Whereas the digoxin (Lanoxin) administered in an oral solution is completely absorbed, that in tablet form is only 75% absorbed. These results are obtained from the cumulative urinary excretion of digoxin rather than serum digoxin concentration curves since the digoxin radioimmunoassay is not sensitive enough to obtain valid data by the latter method. Since digoxin has a steep dose-response curve, a reduction in digoxin dosage is necessary when changing from oral tablet to parenteral administration to avoid the development of digoxin toxicity.
Editorial Board and Contents
Authors: Andrew Clark, Effie Tzameli, Paige Shaklee, Fred Kop, Ria Otten, Patrick Scheffmann, Silvia Arber, Anders Björklund, J Paul Bolam, Sarah Bottjer, Barry Dickson, Chris Doe, Craig Garner, Yukiko Goda, Kenneth Harris, Nancy Ip, Meyer Jackson, Maria Karayiorgou, Robert Malenka, Mark Mattson, Freda Miller, Richard Morris, Maiken Nedergaard, Eric Nestler, Hitoshi Sakano, Greg Stuart, Wolf Singer, Marc Tessier-Lavigne, Chris Walsh
Journal: Trends in Neurosciences (2017)
Neutrophil activation and adhesion molecule expression in a canine model of open heart surgery with cardiopulmonary bypass
Authors: W. J Dreyer, L. H Michael, E. E Millman, K. L Berens
Journal: Cardiovascular Research (1995)

Journal Article Neutrophil activation and adhesion molecule expression in a canine model of open heart surgery with cardiopulmonary bypass Get access William J Dreyer, William J Dreyer * aSperos P Martel Section of Leukocyte Biology and Inflammation Research Baylor College of Medicine, Houston, Texas, USA *Correspondence to Dr Dreyer, at Pediatric Cardiology, Texas Children's Hospital, 6621 Fannin, Houston, TX 77030, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar Lloyd H Michael, Lloyd H Michael bSection of Cardiovascular Sciences Baylor College of Medicine, Houston, Texas, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Ellen E Millman, Ellen E Millman aSperos P Martel Section of Leukocyte Biology and Inflammation Research Baylor College of Medicine, Houston, Texas, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Kurt L Berens Kurt L Berens aSperos P Martel Section of Leukocyte Biology and Inflammation Research Baylor College of Medicine, Houston, Texas, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 29, Issue 6, June 1995, Pages 775–781, https://doi.org/10.1016/S0008-6363(96)88612-3 Published: 01 June 1995 Article history Received: 26 May 1994 Accepted: 19 December 1994 Published: 01 June 1995
Bridging the Gap Between Research and Practice
Authors: William Campbell Felch
Journal: JAMA (1997)

The dream of medicine for the new millennium<sup>1</sup>—that the care of patients will be evidence based, supported by carefully designed randomized controlled trials (RCTs), and validated by focused outcomes studies—will only be fully realized when the major players in the health care arena find improved ways to work together. See also p 115. The first player is the research community, that mix of academia, industry, and government that supplies innovations in medical science and technology, including new drugs, diagnostic tools, and therapeutic devices. The second is the practicing community, mostly physician providers of medical care. This seemingly homogeneous group is in truth a diverse lot, made up of women and men, of soloists and partners, of generalists and specialists, of neophytes and old hands. There are abundant anecdotes suggesting that physicians are unique individuals with widely different characteristics and goals. The issue confronting us is this: How can
Potentiation of Antitumor Effect of Virus-Induced Interferon by Mouse Immune Interferon Preparations&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1980)
Psychometric characteristics of comprehensive geriatric assessments (CGAs) for long-term care facilities and community care: A systematic review
Authors: Mauricio Molinari-Ulate, Aysan Mahmoudi, Manuel A. Franco-Martín, Henriëtte G. van der Roest
Journal: Ageing Research Reviews (2022)

Comprehensive Geriatric Assessments (CGAs) have been incorporated as an integrated care approach effective to face the challenges associated to uncoordinated care, risk of hospitalization, unmet needs, and care planning experienced in older adult care. As they assessed different dimensions, is important to inform about the content and psychometric properties to guide the decisions when selecting and implementing them in practice. This systematic review provides a comprehensive insight on the strengths and weaknesses of the CGAs used in long-term care settings and community care. A systematic search was conducted in PubMed, CINAHL, and Web of Science Core Collection. Studies published up to July 13, 2021, were considered. Quality appraisal was performed for the included studies. A total of 10 different CGAs were identified from 71 studies included. Three instruments were reported for long-term care settings, and seven for community care. The content was not homogenous and differed in terms of the detail and clearness of the areas being evaluated. Evidence for good to excellent validity and reliability was reported for various instruments. Setting more specific and clear domains, associated to the special needs of the care setting, could improve informed decisions at the time of selecting and implementing a CGA. Considering the amount and quality of the evidence, the instrument development trajectory, the validation in different languages, and availability in different care settings, we recommend the interRAI LTCF and interRAI HC to be used for long-term facilities and community care.
Cosmetic Management of Nevi
Authors: Otto C. Stegmaier
Journal: JAMA (1967)

Since nevi are the most prevalent of all skin tumors and since many are situated on the face, patients frequently request their removal for cosmetic reasons. A brief clinicopathologic description of the life cycle of the nevus<sup>1</sup>will be presented first as a guide to the physician in the cosmetic management of nevi. The description presented here applies only to white skins and may or may not be applicable to other races. The method of removing nevi for cosmetic reasons will then be presented. This discussion of nevi is limited to those arising from nevus cells and does not include other birthmarks, such as hemangiomas, which are sometimes called nevi. <h3>Life Cycle of the Nevus</h3> The pigmented nevus (nevus cell nevus, or common mole) is peculiar to man and is the most common neoplasm found in humans. Everyone has a few nevi somewhere on his body; most persons age
Nitrosamine Studies: Neoplasms of Liver and Genital Mesothelium in Nitrosopyrrolidine-Treated MRC Rats&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1972)
The Acute Respiratory Distress Syndrome
Authors: J Mancebo
Journal: New England Journal of Medicine (2000)

The pathophysiology of acute respiratory distress syndrome (ARDS) is characterized by pulmonary edema due to extravasation from capillary lesions in the endothelium. A clinical diagnosis is made when there is a predisposing cause (sepsis and pneumonia being the most common) that gives rise to acute respiratory insufficiency (PaO2/FiO2 ratio (3/4) 200 mmHg, bilateral infiltrates visible on a chest film and hemodynamic or other clinical signs of left cardiac insufficiency). Most patients require invasive support ventilation at a high FiO2 and positive end-expiratory pressure (PEEP). The only therapeutic approach available at this time associated with a highly significant decrease in mortality in patients with ARDS is ventilation at low flow volumes (6 ml/kg) and moderate levels of PEEP (approximately 10 cmH2O).
Warning Patients About Alcohol Abuse
Authors: Robert J. Volk
Journal: JAMA (1992)

<h3>To the Editor.</h3> —In a recent issue of<i>JAMA</i>, Walsh et al<sup>1</sup>presented findings from a treatment outcome study concerning the impact of a physician's warning of the harmful effects of alcohol on recovery after alcoholism treatment. This study's findings highlighted the potential for physicians in managing their alcohol-abusing patients. This simple intervention—a physician's warning—was significantly related to better patient outcomes above that explained by conventional treatments. While the findings from this study are encouraging, physicians' recognition of alcohol problems in their patients remains a necessary precursor to intervention. The subjects in this study were all previously identified as alcohol abusers. A crucial issue in recognition of alcoholism by physicians is the variability in accuracy of available self-report and biochemical screens for alcoholism across patient subgroups, a situation well known to clinical epidemiologists as "spectrum bias."<sup>2</sup>It is entirely possible that the sensitivity and specificity of available self-report and
Clinical Trials and Cancer Risk in Japan&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1984)

This paper presents the results of a clinical trial with vitamin A that was performed in Japan for the treatment of various cancers. The results of epidemiologic studies on the relationship between food intake and development of lung cancer in Japan also are reported. Several Japanese groups are studying the combined effect of vitamin A and its derivatives and anticancer chemotherapeutic agents on the in vitro and in vivo growth of various cancer cells; however, few clinical trials of these combinations for cancer treatment have been conducted. The results of these few studies are reviewed.
Identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetics
Authors: Karthik A. Jagadeesh, Kushal K. Dey, Daniel T. Montoro, Rahul Mohan, Steven Gazal, Jesse M. Engreitz, Ramnik J. Xavier, Alkes L. Price, Aviv Regev
Journal: Nature Genetics (2022)
The NALCN channel regulates metastasis and nonmalignant cell dissemination
Authors: Eric P. Rahrmann, David Shorthouse, Amir Jassim, Linda P. Hu, Mariaestela Ortiz, Betania Mahler-Araujo, Peter Vogel, Marta Paez-Ribes, Atefeh Fatemi, Gregory J. Hannon, Radhika Iyer, Jay A. Blundon, Filipe C. Lourenço, Jonathan Kay, Rosalynn M. Nazarian, Benjamin A. Hall, Stanislav S. Zakharenko, Douglas J. Winton, Liqin Zhu, Richard J. Gilbertson
Journal: Nature Genetics (2022)

Abstract We identify the sodium leak channel non-selective protein (NALCN) as a key regulator of cancer metastasis and nonmalignant cell dissemination. Among 10,022 human cancers, NALCN loss-of-function mutations were enriched in gastric and colorectal cancers. Deletion of Nalcn from gastric, intestinal or pancreatic adenocarcinomas in mice did not alter tumor incidence, but markedly increased the number of circulating tumor cells (CTCs) and metastases. Treatment of these mice with gadolinium—a NALCN channel blocker—similarly increased CTCs and metastases. Deletion of Nalcn from mice that lacked oncogenic mutations and never developed cancer caused shedding of epithelial cells into the blood at levels equivalent to those seen in tumor-bearing animals. These cells trafficked to distant organs to form normal structures including lung epithelium, and kidney glomeruli and tubules. Thus, NALCN regulates cell shedding from solid tissues independent of cancer, divorcing this process from tumorigenesis and unmasking a potential new target for antimetastatic therapies.