AB1170 IMPACT IN PRENATAL EVALUATION OF PREGNANT WOMEN WITH RHEUMATIC DISEASES BY THE SARS-COV2 PANDEMIC
Authors: A. Y. Lujano Negrete, M. E. Corral Trujillo, C. M. Skinner Taylor, L. Pérez Barbosa, A. Aguilar-Leal, M. C. Rodriguez-Ruiz, L. G. Espinosa Banuelos, A. Cárdenas, D. Á. Galarza-Delgado
Journal: Annals of the Rheumatic Diseases (2022)

Background Due to the SARS-CoV-2 pandemic, an increase in stress, anxiety, and depression has been seen, as well as greater use of substances and a decrease in prenatal care in pregnant women. (1) Women of childbearing age with autoimmune rheumatic diseases (ARDs) experience greater psychological stress, which can negatively influence behavior. (2) Objectives This study aims to compare changes in prenatal laboratory and ultrasound tests by trimester, as well as the detection of anxiety and depression in pregnant women with ARDs due to the SARS CoV-2 pandemic. Methods This study was carried out on pregnant patients with ARDs from the Pregnancy and Rheumatic Diseases clinic of the rheumatology department of the University Hospital “Dr. José Eleuterio González” during the period from February 2018 to August 2021. Two standardized evaluations of anxiety and depression were carried out using the Inventory of Trait and State Anxiety (IDARE) and the Edinburgh Postpartum Depression Scale (EPDS) respectively in the third trimester of pregnancy. Maternal report of alcohol consumption during any trimester of pregnancy, as well as adherence to routine laboratory studies such as structural ultrasound and gestational diabetes screening, was addressed. Positive COVID-19 nasopharynx PCR results were evaluated during pregnancy beginning in the pandemic period (March 2020). The pre-pandemic recruited group was compared with the pandemic group. The comparison of the groups was carried out using the Chi-Square and Fisher tests. A significant value of p &lt; 0.05 was considered. Statistical analysis was performed using the IBM SPSS v.25 program. Results 50 pregnant patients with ARDs were recruited, of which 24 were included in the pre-pandemic group and 26 in the pandemic group. Compared with the pre-pandemic group, pregnant women recruited during the pandemic had a statistically significant higher positivity for state anxiety (p=0.023), likewise trait anxiety, depression, and suicidal ideation were detected more frequently, but the difference was not statistically significant, a higher rate of adherence to laboratory and cabinet studies was found, being significant for laboratories performed in the 1st and 2nd trimesters (0.005 and 0.025 respectively). See Table 1. Table 1. Characteristics of pregnant women with autoimmune rheumatic diseases before and during the SARS-CoV-2 pandemic. Measure Before pandemic n=24 During pandemic Covid Negativen=22 During pandemic Covid Positiven=4 P value a EPDS Positive depression detection (≥10 ) 16.7% 36.4% 50% .197 suicidal ideation 16.7% 0% 25% .099 IDARE Positive state anxiety detection (&gt;45 ) 12.5% 27.3% 75% .023 IDARE Positive trait anxiety detection (&gt;45 ) 8.3% 13.6% 50% .204 Any alcohol consumption during pregnancy 20.8% 4.5% 0% .176 Structural Ultrasound – Mid-Pregnancy 66.7% 95.5% 100% .025 Gestational diabetes screening 75% 86.4% 100% .376 Laboratories First trimester 20.8% 50% 0% 0.005 Second quarter 45.8% 77.3% 100% 0.025 Third trimester 58.3% 81.8% 75% 0.216 IDARE= State and Trait Anxiety Inventory, EPDS= Edinburgh Postpartum Depression Scale. A Chi-square test for categorical variables or Fisher’s exact test where the expected cell n Conclusion A higher frequency of positivity for state anxiety was demonstrated in pregnant women with ARDs recruited during the pandemic, as well as higher trait anxiety, depression, and suicidal ideation, although this increase was not statistically significant. On the other hand, concern about the pandemic and health status could positively influence better adherence to screening and routine studies during pregnancy. References [1]Johnson D, Dave H, Cd LYC. Pandemic-Associated Complications in Pregnant Women with Rheumatic Diseases.:261. [2]Skinner-Taylor CM, Perez-Barbosa L, Corral-Trujillo ME, Perez-Onofre I, Barriga- Maldonado ES, Cardenas-de la Garza JA, et al. Anxiety and depression in reproductive age women with rheumatic diseases. Rheumatology International [Internet]. 2020;40(9):1433–8. Available from: https://doi.org/10.1007/s00296-020-04591-8 Disclosure of Interests None declared