tbuckley/cabot-search huggingface dataset:
Intravenous Therapy: Expanding the Bounds of Safety
Authors: Michael D. Decker
Journal: JAMA (1987)

Intravascular infusion therapy was once a considerable chore. In days gone by, reusable large-bore steel needles made starting infusions a challenge, particularly when they had been transformed into hooks during their previous use. Once in place, needles were secured against all-too-frequent infiltration with elaborate immobilizing constructions of wooden arm boards and yards of adhesive gauze. Infusions were meant to stay in place as long as possible and house officers who developed a talent for placing perpetual infusions were envied by their peers. Over the years, the manufacturers of medical devices provided a continuing series of innovations that made vascular infusion therapy more convenient. Among the first of these was the cheap, disposable needle. Suddenly, all needles were sharp! One of us was a senior medical student when this heaven-sent device first was used at the university hospital. The city hospital downtown, however, was slower to adopt disposable needles. There the
Predictors of atopic dermatitis in Leicester children
Authors: J. BERTH-JONES, S. GEORGE, R.A.C. GRAHAM-BROWN
Journal: British Journal of Dermatology (1997)

There is little contemporary data available on the prevalence of atopic dermatitis (AD) or the risk factors associated with this disease. We therefore performed a prospective study of 1-year-oId children based on a cohort of consecutive births in Leicester hospitals. Parents of 1800 children born between March and May 1992 were asked at the time of the birth to allow their child to be entered on a register. A sample of 499 of these children were invited for interview and examination at 1 year of age. Data were collected on gestational maturity, birth weight, feeding pattern, family history of eczema and atopy, social class and other parameters. Four hundred and thirteen of the 499 children were examined (83%). The overall point prevalence of AD was 10.7% (95% confidence interval, 7·7%–13·7%). The most significant risk factor for a child developing AD was a parental history of eczema.
Allied Medical Education
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MESENTERIC PANNICULITIS
Authors: K Arda, A Keskin, G Aydog, S Bostanoglu
Journal: JAMA (1963)

Mesenteric panniculitis is a non-neoplastic inflammatory process affecting the adipose tissue of the mesentery. It is an extremely rare disease. We report the case of a 30-year-old man with mesenteric panniculitis and describe the radiologic findings.
American Health Care System Management Objectives
Authors: George D. Lundberg
Journal: JAMA (1993)

It is the most difficult and complicated set of challenges that the United States has faced since the Great Depression; to some it seems the moral equivalent of World War II; it will last longer, be more expensive, and stands a chance of being more divisive than the Vietnam War; it intimately involves every inhabitant of our country; it holds hostage the future of what many consider history's greatest profession; it may well determine the success or failure of a president and a federal administration. It is American health care system reform in 1993. We've come such a long way since<i>JAMA</i>began its series "Caring for the Poor" in December 1987. Much of our world changed its attitude when in May 1991, invoking the reformist spirit of Abraham Lincoln,<i>JAMA</i>and our nine specialty journals published literally hundreds of pages on national health care reform.<sup>1,2</sup>For the first
The Natural History of Cerebrovascular Disease
Authors: J. Marshall, D. A. Shaw
Journal: BMJ (1959)

carotid or middle cerebral artery or its branches and found that 22 of the patients had died within two years.Kincaid-Smith, McMichael.and Murphy (1958) observed 79 pat ents with malignante hypertension in whom there was evidence of neurological involvement.There were. 65patients in whom the cau3e of death was ascertained, and in 33 of these it was due to a neurological cause.:However, patients who survived a neurological incident, were no more liable to die of a further incident than'
DIGITALIS INTOXICATION
Authors: D Burckhardt, J S LaDue
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Poster Sessions
Journal: Allergy (2013)

Background: Binding of IgE to FceRI increases the expression of FceRI on mast cells and basophil granulocytes.Distinct properties (affinity of IgE for allergen, clonality of allergen, fraction of specific IgE of total IgE) of the IgE repertoire determine basophil degranulation on exposure to allergen.We investigated whether disease status (atopy or asthma) of the donor influences the sensitivity of mast cells cultured under identical conditions.Method: This study included 12 patients with an objectively confirmed asthma diagnosis according to GINA-guidelines and eight healthy subjects.Allergic sensitisation was defined as a positive skin prick test (>3 mm) response to at least 1 of 10 allergens in a standard panel.Ten subjects were atopic, and 10 were non-atopic.We investigated the sensitivity for IgE-mediated activation of peripheral blood derived mast cells.During the last 2 weeks of culture, mast cells were sensitised with IL-4 and 80 kU/l recombinant human IgE containing two IgE clones (7% + 7%) specific for recombinant mite allergen Der p2.Results: We found no significant difference in the number of mast cells cultured from asthma patients compared to controls.After activation, the maximal CD63 Median Fluorescence Intensity was 20 456 AE 1640 [standard error (SE)] for asthma patients and 22 275 AE 1971 (SE) for controls [not significant (ns)] and the percentage CD63+ mast cells was 54.4% for asthma patients and 48.4% for controls (ns).The sensitivity, EC50 Der p2 , (effective allergen concentration inducing 50% of the maximal response) based on the percentage CD63+ mast cells of all mast cell lines cultured from patients with asthma and controls was comparable (0.332 ng/ml AE 1.235 (SE) for asthma patients and 0.232 ng/ ml AE 1.211 (SE) for controls (ns).There was no difference in mast cell sensitivity between atopic and non-atopic subjects.Conclusion: Cultured mast cells from asthma patients and controls respond with similar sensitivity to allergen activation.Degranulation of cultured mast cells appears to depend more on culture conditions (IL-4, IgE) than on donor status (atopy or asthma).
Breast Cancer in a Male-to-Female Transsexual
Authors: Timothy James Pritchard
Journal: JAMA (1988)

The clinicopathological findings in a patient who developed breast carcinoma ten years after male-to-female sexual reassignment are reported. Only two other cases of transsexual men with breast carcinoma have been reported previously. All three patients received oral estrogens for prolonged periods to maintain secondary female characteristics. The controversies relating to hormonal influences in the etiology of breast cancer in men are discussed herein. (<i>JAMA</i>1988;259:-2278-2280)
Deaths from Asthma in Young People
Authors: K. N. V. Palmer
Journal: BMJ (1972)

present the lesions become more prominent, oedematous, and brilliant in colour.2The rash is more prominent on the flanks, abdomen, shoulders, upper arms, and back and has a special predilection for the palms and soles.3There may well be associated slightly tender superficial lymphadenopathy.If these points are remembered there is little diagnostic difficulty, as the maculopa- pular eruption associated with ampicillin therapy starts most commonly on the exten- sor aspects of the limbs, especially over the knees and ankles, is uncommonly associated with any general reactions,' and, most im- portant of all, rarely occurs less than four days after the start of ampicillin therapy.5 -We are, etc.,
Роль фосфатидилхоліну в корекції гепатобіліарних розладів при захворюваннях кишечника
Authors: E.G. Manzhaliy, S.V. Kosinska
Journal: GASTROENTEROLOGY (2013)

У статті наведено дані про гепатобіліарні розлади при захворюваннях кишечника, описано терапевтичну стратегію їх корекції. Наведено результати власних досліджень ефективності застосування препарату Енерлів® у пацієнтів із цими захворюваннями.
Rhinovirus Infections in an Industrial Population
Authors: Jack M. Gwaltney
Journal: JAMA (1967)

Rhinovirus illness in young adults was characterized by rhinorrhea, nasal obstruction, sneezing, and pharyngeal discomfort. Length of illness ranged from 1 to 33 days, with a median of 7.42 days; one fourth of the illnesses lasted two weeks. Nasal symptoms, hoarseness, and cough occurred more frequently with confirmed rhinovirus common colds than with illnesses from which rhinoviruses were not cultured. Significant neutralizing antibody responses were measured in 77% of 77 paired serum specimens from patients with rhinovirus illness; only 5% had homologous titers of 8 or more in the acute phase of illness. The findings support other data indicating that serum neutralizing antibody develops following the majority of rhinovirus illnesses and is important in preventing symptomatic rhinovirus infection.
Reversible Renal Artery Stenosis Associated With Pheochromocytoma
Authors: David C. Brewster
Journal: JAMA (1982)

An extra-adrenal pheochromocytoma was associated with ipsilateral renal artery stenosis. The pheochromocytoma was initially overlooked when renovascular hypertension was mistakenly diagnosed. The renal artery stenosis proved to be functional and was totally reversed by adrenergic blocking agents, given for hypertension, and subsequent tumor removal. Functional renal artery stenosis caused by catecholamine-induced vasospasm may be more common than previously recognized with pheochromocytomas, particularly those in an extra-adrenal location in the renal hilum. (<i>JAMA</i>1982;248:1094-1096)
Intelligence, Power and Personality
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Development of a Nutrient Data System for International Use: INFOODS (International Network of Food Data Systems)&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;
Authors: Ritva Butrum
 3, Vernon R. Young
Journal: JNCI Journal of the National Cancer Institute (1984)

The current interest in the area of nutrition, diet, and cancer has called attention to some major deficiencies in the data base available to support a variety of research activities in the field. These deficiencies have been especially evident in epidemiologic studies where attempts are being made to characterize the dietary differences existing among various populations who have markedly different incidences of chronic diseases, including cancers, thought to be associated with diet. Such studies have been able to characterize international differences in diet by broad, nutrientfood categorizations, but they suffer from a dearth of detailed information on the nutrient content of the enormous variety of foodstuffs consumed by different populations and by the subgroup populations within each of the countries or geographic areas. At the present time, there is no internationally agreed upon food composition data system that provides a continuum of information on food composition. Current diet and disease studies require data on the human requirements or allowances for essential nutrients and quantified data on the ability of the food supply to provide these factors. In addition, information on other chemical components of foods that represent protection for or risk to good health is needed. Such a comprehensive data base would be helpful in providing criteria for formulation of public policy on diet-related public health issues. The Diet and Cancer Branch of the Division of Cancer Prevention and Control, National Cancer Institute, together with other groups support the development of an International Food Composition Data System (INFOODS) as a response to the need for more complete, reliable, and comprehensive information on the nutrient and nonnutrient composition of foods and beverages and their ingredients.
Meningeal Carcinomatosis
Authors: J J Baiges-Octavio, M Huerta-Villanueva
Journal: JAMA (1963)

Meningeal carcinomatosis is a serious complication of solid tumors, particularly adenocarcinomas of breast, lung and melanoma.In this paper we present a review of the bibliography on this disease, with particular emphasis on etiopathogenic, clinical--especially otoneurophthalmological--diagnostic and therapeutic aspects.Meningeal carcinomatosis presents in advanced stages of cancer and has an ominous prognosis with average untreated survival of from four to six weeks. Its frequency has increased in recent years since patients with systemic cancer now live longer. The characteristic of the disease is involvement of various levels of the nervous system, including encephalic, cranial or spinal nerve and spinal symptoms. Sudden loss of vision or hearing which may progress rapidly may be the initial sign of the disease. Neuroimaging studies (computerized axial tomography, magnetic resonance and isotope studies of cerebrospinal fluid flow) are necessary to evaluate associated metastases and detect obstruction of cerebrospinal fluid flow. Positive cerebrospinal fluid cytological findings confirm the diagnosis. Treatment should be tailored to the individual according to the clinical condition and nature of the tumour and should combine intrathecal chemotherapy and local radiotherapy, although recent studies have shown good results with systemic chemotherapy.A high degree of clinical suspicion is necessary for diagnosis of this uncommon disease, with neurological signs show to be present at different levels and the finding of malignant cells in the cerebrospinal fluid for confirmation of the diagnosis.
Glyburide-reversible cardioprotective effects of calcium-independent phospholipase A2 inhibition in ischemic rat hearts
Authors: C. A. Sargent, M. W. Wilde, S. Dzwonczyk, J. G. Tuttle, H. N. Murray, K. Atwal, G. J. Grover
Journal: Cardiovascular Research (1996)

Objectives: A myocardial calcium-independent PLA2 has been described that is activated during myocardial ischemia and this enzyme may modulate ATP-sensitive potassium channels (KATP). The aim of this study was to determine the effect of an inhibitor of this enzyme, a bromoenol lactone, in isolated globally ischemic rat hearts. Methods: Isolated rat hearts were treated for 10 min with 0.3–6 μM bromoenol lactone and then subjected to 25 min ischemia and 30 min reperfusion. Results: The bromoenol lactone significantly increased coronary flow in nonischemic myocardium, and slightly reduced cardiac function at 6 μM. During global ischemia, time to contracture was significantly increased from vehicle group values in the presence of the bromoenol lactone (EC50 = 1.2 μM). During reperfusion, a concentration-dependent increase in function and a reduction in LDH release were observed for the PLA2 inhibitor. The concentrations of the PLA2 inhibitor which were significantly cardioprotective, inhibited this enzyme in membrane fractions of rat myocardium (IC50 = 0.87 μM). The KATP blocker sodium 5-hydroxydecanoate (5-HD) inhibited the increase in time to contracture observed for the bromoenol lactone. During reperfusion, 5-HD abolished the protective effects of the bromoenol lactone on cardiac function and LDH release. Glyburide had similar effects on the cardioprotective activity of the bromoenol lactone, although it only partially abolished the LDH reducing effect of this agent. Conclusions: The bromoenol lactone protects ischemic myocardium at concentrations which also inhibit calcium-independent PLA2. This cardioprotection can be attenuated by blockers of KATP, suggesting a potential mechanism for modulation of myocardial KATP.
Flow Cytometric Analysis of R3327 Rat Prostate Adenocarcinoma Grown In Vivo and In Vitro&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1982)

Journal Article Flow Cytometric Analysis of R3327 Rat Prostate Adenocarcinoma Grown In Vivo and In Vitro Get access Alice J. Claflin, Alice J. Claflin 4Department of Surgery, University of Miami School of Medicine, P.O. Box 016960, Miami, Fla. 33101. Search for other works by this author on: Oxford Academic PubMed Google Scholar Alan Pollack, Alan Pollack 4Department of Surgery, University of Miami School of Medicine, P.O. Box 016960, Miami, Fla. 33101.5Veterans Administration Medical Center, Miami, Fla. 33125. Search for other works by this author on: Oxford Academic PubMed Google Scholar Theodore Malinin, Theodore Malinin 4Department of Surgery, University of Miami School of Medicine, P.O. Box 016960, Miami, Fla. 33101. Search for other works by this author on: Oxford Academic PubMed Google Scholar Norman L. Block, Norman L. Block 5Veterans Administration Medical Center, Miami, Fla. 33125.6Department of Urology, University of Miami School of Medicine. Search for other works by this author on: Oxford Academic PubMed Google Scholar George L. Irvin George L. Irvin 4Department of Surgery, University of Miami School of Medicine, P.O. Box 016960, Miami, Fla. 33101.5Veterans Administration Medical Center, Miami, Fla. 33125. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 69, Issue 1, July 1982, Pages 79–87, https://doi.org/10.1093/jnci/69.1.79 Published: 01 July 1982 Article history Received: 20 August 1981 Accepted: 05 February 1982 Published: 01 July 1982
Dosage of Acetaminophen
Authors: Ben E. Kitchens
Journal: JAMA (1983)

<h3>To the Editor.—</h3> All physicians who treat children should be alerted to the fact that large numbers of mothers are purchasing acetaminophen as Tylenol Elixir and administering it to their infants with the dropper that comes with the Tylenol Infant Drops. These mothers are doing this thinking they are saving money and are incorrectly assuming that the concentration of the elixir and the drops are the same. In so doing, many infants are receiving an inadequate dose of antipyretic, only about one third of what is needed. This problem should be in the differential diagnosis of any infant with fever that has been difficult for the mother to control with Tylenol.
Another reason to combat infections in cystic fibrosis
Authors: Phil Gunby
Journal: JAMA (1982)

Recurrent infections or other environmental-internal factors, rather than abnormal development, appear to be involved in the tracheobronchial gland hypertrophy and hypersecretion noted in older cystic fibrosis patients. That is the conclusion of researchers at Toronto's Hospital for Sick Children, who say that "this observation emphasizes the importance of aggressive prophylactic therapy to prevent and eradicate infection in the long-term care" of these patients, many of whom now are surviving into adulthood. Jennifer M. Sturgess, PhD, and John Imrie, BSc, examined autopsy specimens from 25 infants who did not have cystic fibrosis and from 22 infants with the disease and either no history of meconium ileus or meconium ileus with or without evidence of lung infection. The tracheal submucosal gland development pattern was similar in infants both with and without cystic fibrosis. However, the infants with cystic fibrosis had increased dilatation of the gland lumens. The investigators hypothesized, but were unable
Endoscopy International Open – recently published
Journal: Endoscopy (2016)

See also: Peroral endoscopic pyloromyotomy accelerates gastric emptying in healthy pigs: proof of conceptEndosc Int Open 2016; 04(07): E796-E799DOI: 10.1055/s-0042-108192 See also: Adjunctive radiofrequency ablation for the endoscopic treatment of ampullary lesions with intraductal extension (with video)Endosc Int Open 2016; 04(07): E748-E751DOI: 10.1055/s-0042-107665 See also: Novel technique of endoscopic full-thickness resection for superficial nonampullary duodenal neoplasms to avoid intraperitoneal tumor disseminationEndosc Int Open 2016; 04(07): E784-E787DOI: 10.1055/s-0042-107666