tbuckley/cabot-search huggingface dataset:
Managing cancer and living meaningfully (CALM): A randomized controlled trial of a psychological intervention for patients with advanced cancer.
Authors: Gary Rodin, Christopher Lo, Anne Rydall, Rinat Nissim, Carmine Malfitano, Joanna Shnall, Camilla Zimmermann, Sarah Hales
Journal: Journal of Clinical Oncology (2017)

LBA10001 Background: Patients with advanced cancer experience substantial distress in response to the burden of disease and the challenge of living meaningfully in the face of impending mortality. We developed a novel, brief, manualized psychotherapeutic intervention called CALM designed to alleviate distress and facilitate adjustment in this population. CALM consists of 3-6 individual sessions delivered over 3-6 months and supports exploration in 4 broad domains: 1) symptom management and communication with health care providers; 2) changes in self and relations with close others; 3) sense of meaning and purpose; and 4) the future and mortality. Methods: Patients with advanced cancer were recruited from outpatient clinics at a comprehensive cancer center and randomized to receive either CALM or usual care (UC). Assessments of depressive symptoms (primary outcome), death-related distress and other secondary outcomes were conducted at baseline, 3 (primary endpoint) and 6 months. ANCOVA was used to test for outcome differences between groups at follow-up, controlling for baseline scores. Results: Three hundred and five participants were recruited and randomized (n = 151 CALM; n = 154 UC). Compliance with the intervention was 77.5% and attrition was 28% (16% deceased, 8% lost to follow-up, 4% withdrew). The CALM group reported less severe depressive symptoms compared to UC at 3 (Δ M1-M2 = 1.09, p &lt; 0.04; Cohen’s d = 0.23) and 6 months (Δ M1-M2 = 1.33, p &lt; 0.01; Cohen’s d = 0.29). Other statistically significant findings in psychological well-being and preparation for the end of life at 3- and 6- months also favored CALM vs UC. Conclusions: CALM is an effective intervention for patients with advanced cancer that provides a systematic approach to alleviate distress and to address predictable challenges. Clinical trial information: NCT01506492.
Idiopathic esophageal ulceration is nearly forgotten in an era of controlled human immunodeficiency virus
Authors: Noor Bekkali, Guido van den Berk, Paul Drillenburg, Dirk van Leeuwen
Journal: Endoscopy (2015)

Correction to: Idiopathic esophageal ulceration is nearly forgotten in an era of controlled human immunodeficiency virusEndoscopy 2014; 46(S 01): E429-E430DOI: 10.1055/s-0034-1377432
The Hope of the Variant.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Risks of consumption of contaminated seafood: the Quincy Bay case study.
Authors: C B Cooper, M E Doyle, K Kipp
Journal: Environmental Health Perspectives (1991)

A recent EPA-sponsored study of sediment and seafood contamination in Quincy Bay revealed elevated levels of several complex organic pollutants frequently of concern in human health assessments. A seafood consumption risk assessment was conducted using data from samples collected in Quincy Bay in the methodology developed for EPA's Office of Marine and Estuarine Protection for such assessments. Results showed estimated plausible, upperbound excess cancer risks in the 10(-5) to 10(-2) range. These results are comparable to those found in other seafood contamination risk assessments for areas where consumption advisories and fishing restrictions were implemented. Regulatory response included consumption advisories for lobster tomalley (hepatopancreas) and other types of locally caught seafood. Uncertainties inherent in seafood risk assessment in general and for the Quincy Bay case are discussed, along with implications for further action.
Hypercoagulable States
Authors: Ralph L. Nachman
Journal: Annals of Internal Medicine (1993)

Purpose: To describe the major pathophysiologic mechanisms underlying inherited and secondary hypercoagulable states and to evaluate the frequency, natural history, diagnosis, and management of the various clinical disorders. Data Sources and Study Selection: Relevant clinical literature obtained from bibliographies in hematology textbooks and from computerized indexes was reviewed. A hypothesis was formed based on this literature review and on recent developments from a number of experimental studies. Data Synthesis: Hypercoagulable states include various inherited as well as acquired clinical disorders characterized by an increased risk for thromboembolism. Primary hypercoagulable states include relatively rare inherited conditions that lead to disordered endothelial cell thromboregulation. These conditions include decreased thrombomodulin-dependent activation of activated protein C, impaired heparin binding of antithrombin III, or down-regulation of membrane-associated plasmin generation. The major, inherited, inhibitor disease states include antithrombin III deficiency, protein C deficiency, and protein S deficiency and should be considered in patients who have recurrent, familial, or juvenile deep-vein thrombosis or occlusion in an unusual location such as a mesenteric, brachial, or cerebral vessel. Secondary hypercoagulable states may be seen in many heterogeneous disorders. In many of these conditions, endothelial activation by cytokines leads to loss of normal vessel-wall anticoagulant surface functions with conversion to a proinflammatory thrombogenic phenotype. Important clinical syndromes associated with substantial thromboembolic events include the antiphospholipid syndrome, heparin-induced thrombopathy, the myeloproliferative syndromes, and cancer. Conclusions: Physiologic thromboregulation occurs at the vessel-wall surface. Quantitative and qualitative deficiencies of normal, steady-state endothelial anticoagulant activities are associated with primary hypercoagulable states. Activated endothelial cell surfaces express a thrombogenic phenotype and contribute to secondary or acquired hypercoagulability.
Annual Meeting of the American Medical Association.
Journal: JAMA (1885)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IN MEMORIAM
Authors: Jack L. Kostyo, Hilton A. Salhanick, Nicholas P. Christy
Journal: Endocrine Reviews (1995)

Alfred E. Wilhelmi, the 47th President of The Endocrine Society, died at his home in Atlanta, Georgia, on Christmas night 1994. He was 84 years old. With his death, the field of Endocrinology lost a leading pioneer in the isolation and preparation of the anterior pituitary hormones, an inspiring and devoted teacher of generations of medical and graduate students, and an ardent advocate and steward of The Endocrine Society. Alfred Wilhelmi was born in Lakewood, Ohio, in 1910, attended public schools in Cleveland, and graduated in 1933 from Western Reserve University with the A.B. degree, Summa Cum Laude, in premedical sciences. That same year, he was awarded a Rhodes Scholarship to attend Oxford University, which granted him a B.A. degree in 1935. He then joined the laboratory of Reginald B. Fisher at Oxford, and 2 years later he was awarded the D. Phil, degree in Biochemistry for his research on the biosynthesis of creatine.
JAMA Reference Directories
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LETTER FROM EUROPE.
Authors: James B. Herrick
Journal: JAMA (1894)

No. IV. Munich, July 21, 1894. <h3>To the Editor:</h3> —In my last letter written several days ago, I promised to say a word concerning the work in obstetrics, gynecology and diseases of children, in Prag. I will be very brief indeed and speak only of a few points that seemed to me of special interest. The obstetrical and gynecological department is presided over by Rosthorn, a young man in his thirties, who was called, I believe, from the position of privat-docent in Vienna to a full professorship in Prag, an unusual honor, especially in the case of so young a man. He is looked upon as a man of unusual promise. His gynecological clinics and his didactic lectures are always well attended. The obstetrical cases are divided evenly between the German school, the Czechish and the school for midwives. This gives to each department about eleven hundred cases a year,
Gastrocolic fistula and gastric ulcer with prolonged glucocorticoid therapy
Authors: R. N. Hoffman
Journal: JAMA (1966)

GASTROCOLIC FISTULAE result primarily from perforations through carcinomas of the colon or stomach. In the majority of cases the primary lesion is a far-advanced colon neoplasm. Rare causes of gastrocolic fistulae are benign gastric ulcers, carcinoid tumor of the colon,<sup>1</sup>and chronic ulcerative colotis.<sup>2,3</sup> Verbrugge<sup>4</sup>reviewed the literature up to 1925 and found only 25 cases of benign gastric ulcer perforating into the colon. Gray<sup>5</sup>found four additional cases listed up to 1955 and added one of her own. Bachman and Rogers<sup>6</sup>in the same year reported a case of benign gastric ulcer with gastrocolic fistula. The patient was a 33-year-old woman who had been on corticosteroid therapy for three years for psoriasis and psoriatic arthritis. Until the gastrocolic fistula had occurred with resultant diarrhea, the patient had no apparent signs or symptoms of gastrointestinal difficulty. Bosien and Tyson,<sup>7</sup>in 1952, reported a patient
Specific Antibody Levels at the Cervix During the Menstrual Cycle of Women Vaccinated With Human Papillomavirus 16 Virus-Like Particles
Authors: Denise Nardelli-Haefliger, Daniel Wirthner, John T Schiller, Douglas R Lowy, Allan Hildesheim, Françoise Ponci, Pierre De Grandi
Journal: JNCI Journal of the National Cancer Institute (2003)

Background: In early-phase trials, a human papillomavirus 16 (HPV16) virus–like particle (VLP) vaccine has been shown to be well tolerated, immunogenic, and protective against HPV16 in women, most of whom were taking oral contraceptives. Previous studies have not determined whether HPV immunization results in specific antibody levels in the human genital tract or whether these levels might vary during contraceptive or ovulatory cycles. Therefore, we determined the levels of total and specific antibodies in the cervical secretions of women who had been immunized with HPV16 VLPs and examined the influence of the menstrual cycle and oral contraceptive use on these levels. Methods: Two groups of women were immunized, seven who were taking oral contraceptives and 11 who were ovulating. After seroconversion, serum and cervical secretions were collected twice weekly for 5 weeks. Total immunoglobulins (IgG and IgA) and vaccine-specific IgGs were determined by enzyme-linked immunosorbent assay. Nonparametric statistical analyses were used to determine the statistical significance of differences in IgG levels between groups, and correlations between serum- and cervical-specific IgG levels were determined by the Spearman correlation coefficient. Results: All participants developed detectable titers of anti-HPV16 VLP IgGs in their cervical secretions after immunization. The cervical titers of specific IgG and total IgGs and IgAs among participants in the contraceptive group were relatively constant throughout the contraceptive cycle. In contrast, the cervical titers of specific IgG and total IgGs and IgAs among participants in the ovulatory group varied during the menstrual cycle, being highest during the proliferative phase, decreasing approximately ninefold around ovulation, and increasing approximately threefold during the luteal phase. Serum- and cervical-specific IgG levels were correlated (r = .86) in women in the contraceptive group but not in women in the ovulatory group (r = .27). Conclusions: The relatively high titer of anti-HPV16 antibodies at the cervix is promising in terms of vaccine efficacy; however, the decrease in antibody titer around ovulation raises the possibility that the HPV16 VLP vaccine might be less effective during the peri-ovulatory phase.
Carcinogenicity of lipid-lowering drugs
Journal: JAMA (1996)

<h3>In Reply.</h3> —Dr Cattley emphasizes the sensitivity of rodents to peroxisomal proliferation as the cause of their susceptibility to fibrate-induced liver cancer. This is only partly reassuring because mild peroxisomal proliferation does occur in humans and because the fibrates also cause Leydig cell tumors in rats. More important, clinical trials<sup>1</sup>suggest that fibrates may increase mortality in humans so rodent carcinogenicity has less marginal weight in clinical decisions involving fibrates than is the case for the statins. Peroxisomal proliferation is not a factor for the statins. We agree with Dr Illingsworth that the exposure of the liver to drugs taken orally exceeds that indicated by peripheral blood measurements. However, the FDA preference for basing equivalency on blood levels is appropriate for lung, thyroid, and testis tumors (each observed with at least 2 cholesterol-lowering drugs), and for malignant lymphomas (observed with pravastatin). We appreciate Dr Laws' letter and regret that
Renal hypertension without main arterial stenosis. Function tests predict cure
Authors: D. F. McDonald
Journal: JAMA (1968)

Hypertensive patients who had a small kidney unilaterally underwent renal function tests. Patients who did not have arteriographic evidence of renal arterial stenosis were subjected to nephrectomy when they had nonfunctioning or functionally ischemic kidneys. The test correctly predicted whether a cure would occur in three of three patients with pyelonephritis and in 14 of 15 with ischemic hypoplastic kidneys. Nephrectomy cured hypertension in seven of nine patients with nonfunction. A comparison of these results with the results in 50 patients with renal arterial stenosis indicates that the predictive value of renal funcion tests was greatest in hypertensive patients who had small kidneys without renal arterial stenosis.
Transmission of Ballistocardiographic Forces to Platforms on Springs
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Synopsis of Genitourinary Diseases
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evidence Supporting a Role for Active Oxygen Species in Asbestos-Induced Toxicity and Lung Disease
Authors: Brooke T. Mossman, Joanne P. Marsh
Journal: Environmental Health Perspectives (1989)

Asbestos is an important occupational and environmental toxicant that affects several cell types in the respiratory tract. In an effort to understand how asbestos causes cell injury and/or altered proliferation and differentiation of cells, this laboratory has focused on reactive oxygen species as mediators of asbestos-induced biological effects. A compendium of experimental results reported by this laboratory and others supports this hypothesis. For example, scavengers of reactive oxygen metabolites and iron chelators (i.e., desferroxamine) prevent cytotoxicity after addition of asbestos to a variety of cell lines and macrophages in vitro. DNA strand breakage associated with toxicity of crocidolite asbestos in C3H10T 1/2 cells also is ameliorated with use of desferroxamine. All types of asbestos cause lipid peroxidation in mammalian cells and artificial membranes, a phenomenon that can be prevented by removal of catalytic iron. Last, asbestos causes generation of active oxygen species after interaction with leukocytes or by reduction of oxygen on the surface of the fibers.
Immunohistochemical Techniques and Their Applications in the Histopathology of the Respiratory System
Authors: Ilona Linnoila, Peter Petrusz
Journal: Environmental Health Perspectives (1984)

Subsequent to the first report in the 1940s on incubation of tissue sections with fluorescein-conjugated antibodies for localization of antigens, a great number of modifications were introduced to improve the validity of immunohistochemistry which has become a growingly popular tool. The use of immunoenzymatic techniques eliminates the need for expensive fluorescence microscopy equipment, the lack of permanency of preparations and the lack of electron density required in ultrastructural localization of antigens. Regardless of the technique, it is also important to choose a correct fixation which allows the proper preservation of antigens and morphology and the penetration of antibodies through the entire thickness of the preparation. A variety of immunohistochemical techniques have been applied to study several components of the lung, such as collagen, surface active material, lung specific antigens, and enzymes and the detection of tumor markers, immunoglobulins and infectious agents in the respiratory system which is reviewed. The large surface area and the multiplicity of cell types provided by the respiratory tract epithelium of humans for exposure to microbial as well as toxic substances in the environment make this organ system very vulnerable but a good early indicator of adverse health effects. Immunohistochemistry provides valuable information complementary to the immunochemical and biochemical characterization of this barrier.
A Survey of the Law Concerning Dead Human Bodies.
Journal: JAMA (1930)

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