tbuckley/cabot-search huggingface dataset:
Comparative Study of Clinical and Functional Pattern in Emphysematous Patients With and Without Chronic Respiratory Failure
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Crystallization of Prostaglandin-H Synthase for X-Ray Structure Analysis
Authors: Karin Jahnke, Gisela H. Degen, Manfred Buehner
Journal: Environmental Health Perspectives (1990)

Prostaglandin-H (PGH) synthase from ram seminal vesicles is a dimeric integral membrane protein of molecular weight 140 kDa. PGH synthase is a key enzyme in the biosynthesis of prostaglandins, has cyclooxygenase and peroxidase activities, and contains heme as a coenzyme. In the peroxidation step of its reaction. PGH synthase can use xenobiotics as co-substrates and can catalyze the metabolic activation of carcinogens such as diethylstilbestrol. To gain a detailed understanding of the inner workings of PGH synthase, we are investigating its three-dimensional structure by X-ray crystallography. A purification procedure was established that yields stable homogeneous PGH synthase that is at least 80% holoenzyme. The crucial aspect is the proper choice of type and concentration of detergent in all steps of the procedure. Single crystals can be obtained from concentrated solutions of PGH synthase in the presence of polyethylene glycol 4000 as a precipitant. Crystallization occurs during gas phase equilibration with a concentrated salt solution. The enzyme solution becomes turbid and forms a second liquid phase in which PGH synthase crystals grow up to 0.2 mm in length in the course of days. Manipulation of these crystals is very difficult due to the small volume of the growth phase. The crystals dissolved rapidly in all aqueous media into which they were transferred for mounting in X-ray capillaries. Therefore, we have not yet been able to demonstrate their true X-ray scattering power. A crystal provisionally dry mounted diffracted to about 8 A resolution.
Bequests to Hospitals.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Commentaire du travail de Kerdsirichairat T. et al., pp. 1085
Journal: Endoscopy (2014)

See also: Urgent ERCP with pancreatic stent placement or replacement for salvage of post-ERCP pancreatitisEndoscopy 2014; 46(12): 1085-1094DOI: 10.1055/s-0034-1377750
THE VALUE OF GASTRIC ANALYSIS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Optic and peripheral neuropathy in Cuba
Authors: A. A. Sadun
Journal: JAMA (1994)

<i>The following letters were accepted after Hirano et al had responded to Hedges et al</i>.—Ed. <h3>To the Editor.</h3> —We read with great interest the Letter From Havana by Lincoff et al.<sup>1</sup>By invitation from the Cuban Ministry of Health, we visited Cuba in May 1993, the week after the visit by Lincoff et al, and again in September 1993. By the end of May 1993, the Cuban government was frantically trying to address a crisis that affected 42 653 people. In our systematic neuro-ophthalmological examinations, certain clinical features were regularly noted. Remarkably, about half of the conditions that we identified in May were misdiagnosed. We, as representatives of ORBIS International and the Pan American Health Organization, proposed that the Cuban Ministry of Health adopt a strict case definition (Table).<sup>2</sup> With this strict case definition and a smaller but more reliable database, many risk factors appeared more
Conference on Industrial Application of Radioisotopes and Radiation Technology
Journal: JNCI Journal of the National Cancer Institute (1981)

Journal Article Conference on Industrial Application of Radioisotopes and Radiation Technology Get access JNCI: Journal of the National Cancer Institute, Volume 66, Issue 1, January 1981, Page 213, https://doi.org/10.1093/jnci/66.1.213-d Published: 01 January 1981
The effect of zinc supplementation on pregnancy outcome
Authors: R. L. Goldenberg
Journal: JAMA (1995)

<h3>Objective.</h3> —To evaluate whether zinc supplementation during pregnancy is associated with an increase in birth weight. <h3>Design.</h3> —A randomized double-blind placebo-controlled trial. <h3>Setting.</h3> —Outpatient clinic and delivery service at the University of Alabama at Birmingham. <h3>Patients.</h3> —Five hundred eighty medically indigent but otherwise healthy African-American pregnant women with plasma zinc levels below the median at enrollment in prenatal care, randomized at 19 weeks' gestational age. Women were subdivided by the population median body mass index of 26 kg/m<sup>2</sup>into two groups for additional analyses. <h3>Intervention.</h3> —Women who were taking a non—zinc-containing prenatal multivitamin/mineral tablet were randomized to receive either a daily dose of 25 mg of zinc or a placebo until delivery. <h3>Main Outcome Measures.</h3> —Birth weight, gestational age at birth, and head circumference at birth. <h3>Results.</h3> —In all women, infants in the zinc supplement group had a significantly greater birth weight (126 g,<i>P</i>=.03) and head circumference (0.4 cm,<i>P</i>=.02) than infants in the placebo group. In women with a body mass index less than 26 kg/m<sup>2</sup>, zinc supplementation was associated with a 248-g higher infant birth weight (<i>P</i>=.005) and a 0.7-cm larger infant head circumference (<i>P</i>=.007). Plasma zinc concentrations were significantly higher in the zinc supplement group. <h3>Conclusions.</h3> —Daily zinc supplementation in women with relatively low plasma zinc concentrations in early pregnancy is associated with greater infant birth weights and head circumferences, with the effect occurring predominantly in women with a body mass index less than 26 kg/m<sup>2</sup>. (<i>JAMA</i>. 1995;274:463-468)
A large colonic intraluminal mass in a young man with chronic diarrhea
Authors: R. J. Gould
Journal: JAMA (1983)

<h3>History</h3> A 22-year-old man with a 12-year history of intermittent abdominal pain and diarrhea had an exacerbation of the diarrhea and weight loss. Representative roentgenograms of an air-contrast barium enema examination (Figs 1 and 2) are illustrated. A single-contrast barium enema study performed five years earlier had shown similar findings. <h3>Diagnosis</h3> Giant postinflammatory pseudopolyposis of Crohn's colon. <h3>Comment</h3> The supine roentgenogram from the air-contrast barium enema examination (Fig 1) demonstrated multiple sessile- and filiform-appearing polyps in the ascending, transverse, and descending colon. The sigmoid colon and rectum (not shown) were normal. A spot x-ray film (Fig 2) of the hepatic flexure showed a 5-cm polyp that had incorporated several filiform polyps. The presence of multiple filiform- and sessile-appearing polyps in a patient with a long history of gastrointestinal complaints indicative of inflammatory bowel disease should strongly suggest postinflammatory pseudopolyposis. The sparing of the rectosigmoid and asymmetric involvement of the more
Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-α–stimulated STAT2-independent production of IFN-γ in the brain
Authors: Jianping Wang, Ngan Pham-Mitchell, Christian Schindler, Iain L. Campbell
Journal: Journal of Clinical Investigation (2003)

The type I IFNs (IFN-α and IFN-β), which are crucial in antiviral defense and immune regulation, signal via the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway with activation of STAT1 and STAT2. Here, the function of STAT2 was studied in transgenic mice (termed GIFN/STAT2–/–) with CNS production of IFN-α. Surprisingly, GIFN/STAT2–/–, but not GIFN/STAT1-null, transgenic mice, with CNS production of IFN-α, died prematurely with medulloblastoma. An immune response also induced in the brain of the GIFN/STAT2–/– mice was associated with IFN-γ gene expression by CD3+ T cells and the activation of the STAT1, STAT3, STAT4, and STAT5 molecules. Expression of the Sonic hedgehog (Shh) and the downstream transcriptional factor Gli-1 genes, implicated in the pathogenesis of medulloblastoma, was found to be significantly increased and cotranscribed in cerebellar granule neurons of the GIFN/STAT2–/– mice. IFN-γ, but not IFN-α, induced STAT1-dependent expression of the Shh gene in cultured cerebellar granule neurons. Thus, there is an unexpected and extraordinarily adverse biological potency of IFN-α in the CNS when the primary signal transduction molecule STAT2 is absent. Moreover, a hitherto unknown role is indicated for the immune system in the pathogenesis of developmental disorders and tumorigenesis of the CNS via dysregulated Shh signaling mediated by IFN-γ.
Interaction between neutrophils and cholangiocytes causes cholestasis in alcoholic hepatitis
Authors: Masahiro Takeuchi, Paula Vidigal, Mateus Guerra, Melanie Hundt, Marie Robert, Maria Olave-Martinez, Satoshi Aoki, Tanaporn Khamphaya, Remco Kersten, Emma Kruglov, Jesus M. Banales, Michael Nathanson, Jittima Weerachayaphorn
Journal: Journal of Hepatology (2020)
Abstract 2739: EZH2 promotes breast cancer bone metastasis
Authors: Jingkun Qu, Lin Zhang, Zhifen Zhou, Dihua Yu
Journal: Cancer Research (2019)

Abstract Metastasis causes about 90% of cancer deaths and approximately 55% of breast cancer patients develop bone metastases. Although significant advances in the cure of breast cancer, effective therapies targeted bone metastases are still not available. To develop novel therapies for patients with bone metastasis, better understanding of underlying mechanisms of bone metastasis is critical. EZH2 is a classic histone methyl transferase that generally suppresses downstream target genes through tri-methylation of H3K27. EZH2 is considered as a breast cancer oncogene and is frequently over expressed in breast cancer, but the effect of EZH2 on bone metastasis is unknown. To explore the function of EZH2 in bone metastasis, we intracardially injected into nude mice control MDA.MB.231 breast cancer cells expressing readily detectable EZH2 or a MDA.MB.231 subline having EZH2 knocked out (231.EZH2.ko). We found that the mice injected with 231.EZH2.ko had prolonged bone metastasis-free survival compared to the control group of mice. To gain initial insight on the underlying mechanism of EZH2-mediated bone metastasis, we co-cultured MDA.MB.231 cells or 231.EZH2.ko with pre-osteoclasts (RAW264.7) and osteoblasts (MC3T3) under TGF-β treatment (triple co-culture) to mimic bone metastasis tumor microenvironment. We examined osteoclast maturation and breast cancer cell proliferation because osteolysis induced by mature osteoclasts is critical for breast cancer cell growth in the bone metastasis. In triple co-culture of MDA.MB.231 cells, more RAW264.7 pre-osteoclasts were differentiated to mature osteoclasts, as measured by TRAP+ staining, a marker of mature osteoclasts, and MDA.MB.231 cells grew faster than the triple co-culture of 231.EZH2.ko cells. Furthermore, we found that the mRNA level of PTHrP, a master regulator of bone metastasis and a TGF-β downstream cytokine, was expressed at significantly higher level in MDA.MB.231 cells than that in 231.EZH2.ko cells under TGF-β stimulation. PTHrP was known to promote the “vicious cycle” of bone destruction in bone metastasis. The data suggests EZH2 promotes breast cancer bone metastasis through PTHrP. Currently, we are further exploring how EZH2 regulates PTHrP in breast cancer cells to promote bone metastasis. Our studies may reveal novel biomarkers and/or therapeutic targets for bone metastasis. Citation Format: Jingkun Qu, Lin Zhang, Zhifen Zhou, Dihua Yu. EZH2 promotes breast cancer bone metastasis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2739.
A 61-year-old man with Parkinson's disease
Authors: R. J. White
Journal: JAMA (1996)

<h3>To the Editor.</h3> —I must take exception to the discussion by Dr Olanow<sup>1</sup>of the presumed clinical benefits and improvements that resulted from fetal tissue transplantation in patients with PD. Landau<sup>2</sup>has addressed this topic. The clinical improvement described in the patients who received transplants, based almost exclusively on clinical criteria, differs very little from that reported earlier with adrenal gland grafting. This technology has subsequently proven to be of no value. Olanow mentions the measured increases in "striatal fluorodopa uptake," using positron-emission tomography (PET) scanning, but, at present, it is not known whether this is indicative of dopamine production by the graft or is an irritative effect on the surrounding brain. He reinforces his belief in the success of this method by mentioning the single autopsy case<sup>3</sup>that demonstrated some cellular survival in the fetal brain graft. No neuropathologist would argue that this was evidence of "robust graft survival,"
Introduction
Authors: Anne E. Crowley
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PRIMULA DERMATITIS
Authors: O. H. FOERSTER
Journal: JAMA (1910)

That the primula or primrose, a flowering plant found in many homes as a floral decoration, is frequently the cause of a dermatitis of more or less severe degree, is a fact not sufficiently recognized by the medical profession. In this country attention was first called to the poisonous property of the species of Primula known as<i>Primula obconica</i>, by J. C. White<sup>1</sup>in 1889 and again in 1890, when several cases observed in florists were reported.<sup>2</sup>With the exception of case reports by Denston<sup>3</sup>and Sweet,<sup>4</sup>there have been no further contributions to this subject by American writers, and in the consideration of dermatitis venenata in the latest dermatologic text-books the primula is either omitted entirely or is barely mentioned. This is in marked contrast to the large number of articles on this subject which have appeared in recent years, especially in English and German
Child Psychiatrists Address Problem of Youth Violence
Authors: S. Lurie
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Poliomyelitis Vaccination
Authors: Edward B. Shaw
Journal: JAMA (1967)

<h3>To the Editor:—</h3> I find the paper by Swanson, McAlister and Peterson (<b>201</b>:771, 1967) quite disturbing. The introductory summary concludes with the sentence, "Physicians should inquire about the immunization status of parents before administering vaccine to children." —And do what? The final sentence in the paper reads: "Nevertheless it seems reasonable to suggest that the immunization status of parents should receive some attention prior to administration of oral attenuated polio vaccine to their children, particularly if the parents have never been immunized against polio." Certainly these statements will dissuade some physicians from the use of oral polio vaccine. Must one vaccinate the parents first, and if so, would this endanger the children in the family? Should the entire family be vaccinated as a unit? What then about contacts outside of the household? At the present time, if live virus vaccine is incriminated as the cause of paralytic disease, only
JHEP at a glance (December 2018)
Authors: Christoph Sarrazin, Curtis Cooper, Michael Manns, Marc Bourliere, Stefan Zeuzem, Steven Flamm Correspondence, Hadas Dvory, Chunkyu Ko, Anindita Chakraborty, Wen-Min Chou, Jane Mckeating, Wang-Shick Ryu, Ulrike Protzer
Journal: Journal of Hepatology (2018)
Blindness of an adult caused by oxygen
Authors: T. Kobayashi
Journal: JAMA (1972)

A 32-year-old man suffering from myasthenia gravis developed a retinal atrophy after 150 days of hyperoxia through artificial ventilation with 80% oxygen. The atrophy resulted from a constriction of the retinal artery, and the patient lost the sight of both eyes. This case might be the first reported irreversible retinal damage in an adult human induced by excessive oxygen.
P154 Safety of tiotropium in pre-school children with symptomatic persistent asthma
Authors: H Bisgaard, M Vandewalker, L Graham, P Moroni-Zentgraf, M Engel, G El Azzi, SD Vulcu, H Finnigan, EJLE Vrijlandt
Journal: Thorax (2016)

<h3>Introduction and objectives</h3> Asthma is the most common chronic disease of childhood (GINA 2015). For pre-school children whose asthma symptoms are not well controlled on inhaled corticosteroids, limited options are available for further treatment. Here, we evaluated the safety of once-daily (QD) tiotropium Respimat® (tioR) in patients aged 1–5 years with symptomatic persistent asthma. <h3>Methods</h3> A Phase II/III, randomised, double-blind, placebo-controlled, parallel-group trial (NCT01634113) of tioR 5 μg, tioR 2.5 μg or placebo Respimat® (pboR), administered QD in the afternoon for 12 weeks, each as add-on to usual maintenance therapy. Safety data, including <i>post hoc</i> analysis of a composite exacerbation end point derived from adverse events (AEs), are reported. <h3>Results</h3> No AEs leading to treatment discontinuation or death were reported. The proportion of patients with any AEs was higher with pboR (73.5%) than with tioR 5 μg (58.1%) and 2.5 μg (55.6%). Two patients each in the tioR 5 μg (6.5%) and pboR (5.9%) groups were reported with drug-related AEs. Three patients, all in the pboR group, were reported with serious AEs. Asthma exacerbation/worsening was reported by fewer patients in the tioR 5 μg and tioR 2.5 μg groups compared with the pboR group (Table). <h3>Conclusion</h3> Once-daily tiotropium Respimat® add-on to maintenance therapy is well tolerated and may reduce exacerbations in pre-school children with symptomatic persistent asthma.
Stress Echocardiography.
Authors: J Roeland
Journal: Cardiovascular Research (1994)

Journal Article Stress Echocardiography. Get access J Roeland J Roeland Rotterdam, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 1, January 1994, Page 143, https://doi.org/10.1093/cvr/28.1.143B Published: 01 January 1994