tbuckley/cabot-search huggingface dataset:
THE PLAGUE AT SYDNEY.
Journal: JAMA (1901)

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Deaths
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The spatial distribution of lobular in situ mammary carcinoma. Implications for size and site of breast biopsy
Authors: P. A. Lambird
Journal: JAMA (1969)

Detection of lobular in situ mammary carcinoma (LIS) requires microscopic study of the breast. To improve the yield of necessarily blind biopsies, we plotted the spatial distribution of LIS in nine breasts, eight of which were totally and one partially embedded. Lobular in situ carcinoma is concentrated in the upper quadrants beneath the areolar periphery; 47.8% is found within 5 cm of the nipple. Peripherally, LIS involves radial mammary sectors, often skipping contiguous radii. To detect LIS, all breasts requiring surgery should be entered through a circumareolar incision. Biopsies should be taken routinely of breast tissue lying 3 to 4 cm from the nipple in an arc perpendicular to radii from the nipple, sampling all upper-quadrant duct systems. With proper tissue processing in pathology laboratories, such biopsies should detect LIS, if present, with more than 90% success.
Hemoglobin regeneration in severe iron-deficiency anemia. Response to orally and parenterally administered iron preparations
Authors: J. A. Pritchard
Journal: JAMA (1966)

Severe iron deficiency anemia can be corrected very nearly as fast by several inexpensive preparations of oral iron as by iron dextran injection or saccharated iron oxide. The average rate of increase in hemoglobin concentration in 28 women who ingested ferrous sulfate, ferrous gluconate, or ferrous fumarate in amounts which provided 180 to 220 mg of iron per day was 0.25 gm/ 100 ml/day compared to 0.28 gm/100 ml/day in 14 who received iron dextran injection intramuscularly and 0.33 gm/100 ml/day in 14 who were treated with saccharated iron oxide given by intravenous infusion. Ferrous sulfate, ferrous fumarate, or ferrous gluconate in a daily dose containing about 200 mg of iron are very satisfactory for treating most cases of severe iron deficiency anemia.
Resection line disease in stomach cancer. British Stomach Cancer Group.
Authors: M Hockey, J Fielding, K Kelly, L Ward, V Brookes, J Craven, M Mason, H Winsey, M Wrigley, W Allum, A Timothy, J Waterhouse, L Fielding
Journal: BMJ (1984)

In a prospective multicentre study of gastric adenocarcinoma the problem of microscopic disease at the resection line was investigated. Of 390 patients with resected gastric cancer, 85 (22%) had disease of the resection margins--32 at the oesophagus, 20 at the gastric margin, 17 at the duodenum, and six at both margins (10 were unspecified). Some 105 resections were considered palliative and 285 curative; 39 and 46 respectively had resection line disease. When resection margin clearance had been achieved a significantly improved survival was found, both overall (p = 0.0001), in the curative group (p = 0.0009), and in those with serosal disease but no microscopic disease of the lymph nodes (p = 0.0109). When the resection margin was diseased the survival rate for TNM stage IIS fell to that of stage IVA; 16% of those having curative surgery had had inadequate resections. The results of this study show that microscopic disease at the resection line influences long term survival and that surgeons should ensure that resection lines are clear. It also shows that the classification of patients who have resection line disease should be downgraded to stage IVA in the TNM staging system and they should be considered to have had only a palliative resection.
Highlights
Journal: JAMA (2015)

Proliferative diabetic retinopathy is a leading cause of vision loss among patients with diabetes.In a clinical trial conducted at 55 sites by the Diabetic Retinopathy Clinical Research Network, investigators randomly assigned 305 adults (394 study eyes) with proliferative diabetic retinopathy to receive standard treatment with panretinal laser photocoagulation or treatment with intravitreal ranibizumab-an antibody that inhibits vascular endothelial growth factor.The investigators report that treatment with ranibizumab resulted in visual acuity that was noninferior to (not worse than) panretinal photocoagulation treatment at a 2-year assessment.In an Editorial, Olsen discusses treatment of proliferative diabetic retinopathy.
Soluble urokinase plasminogen activator receptor (suPAR) as a serum biomarker for patients undergoing resection of pancreatic adenocarcinoma.
Authors: Sven H Loosen, Marcel Binnebösel, Thomas Longerich, Christian Trautwein, Christoph Roderburg, Ulf Peter Neumann, Tom Luedde
Journal: Journal of Clinical Oncology (2018)

e16203 Background: Surgical resection is the only potentially curative therapy for patients with pancreatic adenocarcinoma (PDAC), representing the malignancy with the lowest 5-year survival rate of any GI cancer. However, even after successful R0 tumor resection, some patients are still facing an unfavourable prognosis and the existing preoperative stratification algorithms are often unsuitable to identify these. The soluble urokinase plasminogen activator receptor (suPAR) was recently described as a promising new biomarker for different clinical conditions including cancer. Here, we evaluated the potential role of circulating suPAR as a biomarker in patients undergoing resection of PDAC. Methods: Expression levels of uPAR, the membrane-bound source of circulating suPAR, were analysed in PDAC tissue samples using IHC. Serum levels of suPAR were measured by ELISA in 128 patients with PDAC, 75 healthy controls as well as 23 with PDAC precursor lesions (pancreatic intraepithelial neoplasia (PanIN) or intraductal papillary mucinous neoplasm (IPMN). Results were correlated with clinical data. Results: In line with an overexpression of uPAR in PDAC tissue samples, serum levels of suPAR were significantly elevated in patients with PDAC and PanIN/IPMN compared to healthy controls. Importantly, PDAC patients with preoperative suPAR serum levels above our defined ideal cut-off value of 6.01 ng/ml showed a strikingly reduced overall survival after tumor resection, which could also be confirmed for patients with PanIN/IPMN. Moreover, multivariate Cox-regression analysis revealed suPAR as a prognostic factor after PDAC resection. Finally, high preoperative suPAR but not creatinine levels identified those patients particularly susceptible to postoperative acute kidney injury. Conclusions: Serum levels of suPAR represent a promising novel biomarker in patients with resectable PDAC that might help to guide preoperative treatment decisions with regards to patients’ outcome and the identification of patients particularly susceptible to postoperative acute kidney injury.
SOME GYNECOLOGIC MISDEMEANORS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dextran-induced anaphylaxis
Authors: G. Bailey
Journal: JAMA (1967)

ANAPHYLACTIC reactions to polysaccharide plasma expanders, such as dextran, are rare, but with their increasing utilization must go an increasing awareness of their potential antigenicity. The first case of anaphylaxis to dextran was reported by Thorsen in 1944.<sup>1</sup>In the 20 years that have followed, there have been scattered reports of dextraninduced anaphylaxis.<sup>2,3</sup>The following is a detailed report of another such case in which antibody studies were done. <h3>Report of a Case</h3> An 18-year-old white boy entered Charity Hospital of Louisiana in New Orleans on Feb 2, 1966. He had sustained an open fracture of the upper third of his right femur in a motorcycle accident. His history revealed several episodes of urticaria following horseback riding. There was no personal history of bronchial asthma, rhinitis, or drug allergy. Family history revealed his father to be exquisitely sensitive to bee stings. The patient had suffered three past episodes
Medical Genetics and Eugenics
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exercise Tolerance Test
Authors: Roger E. Johnsonbaugh
Journal: JAMA (1978)

Parent-directed vigorous exercise was evaluated as a screening test for adequacy of pituitary growth-hormone release in 57 short-statured children. This method obviated the need for pharmacologic provocative testing in all but the four children with growth-hormone deficiency. In 92% of the euendocrine children, the immediate postexercise venous sample demonstrated an adequate growth-hormone level. Vigorous physical exercise after an 8- to 12-hour fast with a single postexercise serum growth-hormone sample is a reliable, safe, and cost-effective screening test for growth-hormone deficiency. (<i>JAMA</i>240:664-666, 1978)
Cystic fibrosis. An expanding challenge for internal medicine
Authors: W. J. Warwick
Journal: JAMA (1977)

The number of adults with cystic fibrosis (CF) receiving care from the US Cystic Fibrosis Centers has been increasing at an average rate of about 200 patients each year. A model based on the continuation of this rate of increase predicts that almost 4,000 adults will be receiving care at the centers by the end of 1985. Four other models developed are based on continuation of a steady state with two variations: a 50% reduction in mortality and universal newborn screening. These models show the boundaries of an equilibrium population to be between 24,000 and 64,000 patients, with 7,000 to 18,000 adults. (<i>JAMA</i>238:2159-2162, 1977)
Medical News &amp;amp; Perspectives
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WHO Regional Office for Europe and UNAIDS report on progress since the Dublin Declaration
Authors: Collective Editorial team
Journal: Eurosurveillance (2008)

Preview this article: WHO Regional Office for Europe and UNAIDS report on progress since the Dublin Declaration, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/13/37/art18981-en-1.gif
Reports
Journal: JAMA (1969)

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Letter: Confidentiality.
Authors: F Levy
Journal: BMJ (1974)

thyroiditis is common (7-8 of palpable goitres in our material) and a considerable number of these cases will turn up within some years with manifest myxoedema and often advanced coronary disease if not previously treated with thyroxine in the thyroiditic phase of the disease.Fine needle biopsy may be valuable in the diagnosis of thyroid cancer but it is in- dispensable for the diagnosis of thyroiditis and thus for the prevention of myxoedema.It is a simple and innocuous method-but it is, of course, possible to manage thyroid disease also without it.-Iam, etc.,
EPIDEMIC ENCEPHALITIS
Authors: P. G. Crookshank
Journal: JAMA (1923)

<h3>To the Editor:</h3> —In a recent leading article inThe Journal, reference is made to some views that I am supposed to hold, and which, it is said, are no longer seriously considered. I am sure you will allow me space to say that the belief that poliomyelitis and encephalitis lethargica have the same virus, or that the virus of encephalitis lethargica is the same, or a variation of that of poliomyelitis, does not quite accurately represent my position. So far as I can see, there has not yet been put forward any single clinical, epidemiologic or pathologic criterion that clearly separates the vast mass of these nervous cases into two groups: that enables us to say definitely, in respect of<i>all</i>cases, which should be put on the left and which on the right. So long as this is so, it seems to me wise to use one common
A Text-Book of Medicine.
Journal: JAMA (1927)

This tremendous volume covers the entire field of internal medicine. More than 120 authors have contributed to its pages. A study of the references to the article on influenza indicates no literature later than 1922, although undoubtedly the author, Dr. Blake, must have been familiar with more recent discoveries. He is somewhat doubtful as to the proof available for the direct causative relationship of<i>Bacillus pneumosintes</i>to this disease. In the article on lobar pneumonia, Dr. Cecil recommends particularly the use of oxygen and the usual symptomatic treatment. He is obviously inclined to favor the work done by Cole, himself and Blake with antipneumonia serums. He favors the use of Huntoon's antibodies, particularly in type I cases, at least by his method of presenting the evidence for this product. The article on scarlet fever was prepared by Helmholz, who recommends the use of Dick antitoxin in acute severe cases, whereas
Smoking and Health
Journal: JAMA (1968)

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SOME ANNIVERSARIES OF 1926
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABC of adolescence: Substance misuse: alcohol, tobacco, inhalants, and other drugs
Journal: BMJ (2005)

with the findings of Hill et al and Devereaux et al might reflect the difference in response rate, criteria for adequate concealment, recentness of the included trials, or the strategies for contacting and phrasing the questions to the investigators.It is prudent to assume that a notable fraction of the overestimation of the treatment effect associated with unclear allocation concealment is caused by selection bias.This fraction can be reduced through several mechanisms.Journals should endorse and enforce the consolidated standards of reporting trials statement (www.consort-statement.org),which recommends explicit description of the allocation procedures in publications of trials, and the gatekeepers who sanction protocols for funding and approval should demand that adequate methods are described in protocols and implemented in trials.Furthermore, our study adds to the argument that protocols should be made publicly available, 9 18 19 because public access would increase the reliability of critical appraisal of the fraction of trials where the protocol does describe methods for allocation concealment.We thank the scientific and ethical committees for Copenhagen and Frederiksberg, who provided access to the trial protocols and offered administrative support; the researchers who responded to the questionnaires; and J Hedegaard for secretarial support.