tbuckley/cabot-search huggingface dataset:
60 Years of Chemical Carcinogens: Sir Ernest Kennaway in Retirement
Authors: R E Waller
Journal: Journal of the Royal Society of Medicine (1994)

1992 marks the sixtieth anniversary of the publication of the first paper on the production of cancer by pure hydrocarbons, by the team at the Chester Beatty Research Institute headed by Professor Kennaway. Studies on polycyclic aromatic hydrocarbons and other chemical carcinogens continued to thrive under his leadership in succeeding years at the Chester Beatty and beyond, into his ‘retirement’ in 1946. He played a key role in stimulating research on factors contributing to the epidemic of lung cancer that became apparent by then, and with the support of the Medical Research Council (MRC) and other organizations he directed a small team working on analytical and epidemiological studies in a makeshift laboratory at St Bartholomew's Hospital. Published work included the identification and determination of benzo(a)pyrene in domestic soot, urban air pollution, motor vehicle exhausts and cigarette smoke, also arsenic in urban air and cigarette smoke, radon in indoor air and carbon deposits in human lungs. Such studies have been pursued in other laboratories around the world since then, and many of the lines of enquiry are traceable back to the pioneering work of the team at the Chester Beatty 60 years ago.
Cryotherapy as a Palliative Maneuver
Authors: John H. Beggs
Journal: JAMA (1968)

Cryotherapy, which involves use of profound cold in the region of —190 C, has recently been popularized as a definitive therapeutic tool. Externally malignant processes, untreatable by the usual methods, were subjected to palliative freezing. Studies to determine modes of action were not undertaken. Gratifying results were obtained and further use seemed justified in that decreased pain, reduced number of dressings, and smaller resultant tumor volume were notable advantages.
A Statistical Model of the Natural History of Cervical Carcinoma Based On a Prospective Study of 557 Cases&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Barron, Bruce A., Richart, Ralph M.
Journal: JNCI Journal of the National Cancer Institute (1968)

Journal Article A Statistical Model of the Natural History of Cervical Carcinoma Based On a Prospective Study of 557 Cases Get access Bruce A. Barron, Ph.D., Bruce A. Barron, Ph.D. The Rockefeller University and the Departments of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, and the Obstetrical and Gynecological Service (The Sloane Hospital) of the Presbyterian Hospital, New York, New York 10032 Search for other works by this author on: Oxford Academic PubMed Google Scholar Ralph M. Richart, M.D. Ralph M. Richart, M.D. The Rockefeller University and the Departments of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, and the Obstetrical and Gynecological Service (The Sloane Hospital) of the Presbyterian Hospital, New York, New York 10032 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 41, Issue 6, December 1968, Pages 1343–1353, https://doi.org/10.1093/jnci/41.6.1343 Published: 01 December 1968 Article history Received: 03 July 1968 Accepted: 27 August 1968 Published: 01 December 1968
Photo finish
Authors: David Strachan
Journal: BMJ (1994)

The Christmas "clacker" A 44 year old occasional drinker presented to the accident and emergency department at 5 30 am on New Year's Day.A sensation at the back of his throat was causing a slight discomfort on breathing.On examination his uvula was found to be swollen.He had suffered the same problem on Christmas Day moming the previous year, the common factor being alcohol consumption during the previous evening.It is well known that alcohol consumption triggers or worsens snoring.Overindulgence causes muscle hypotonia and depression of the arousal mechanisms, leading to many people sleeping flat on their backs rather than on their sides.This narrows the airway and leads to a tendency to obstruction.If a kick in the back from a disgruntled partner does not rectify the situation and the "comatose" state persists then forced inspiration through a narrowed airway causes repeated trauma of the uvula and swelling.-
Abnormal Expression of Vimentin Intermediate Filaments in Human Lymphoid Cell Lines With Deletion or Translocation of the Distal End of Chromosome 8
Authors: Koussay Dellagi, Jean-Claude Brouet, Marie-Madeleine Portier, Gilbert M. Lenoir
Journal: JNCI Journal of the National Cancer Institute (1984)

The expression of vimentin, the major polypeptide of the intermediate filament (IFM) cytoskeleton of lymphoid cells, was studied in normal and malignant human lymphoid cell lines. Cells from 24 of 27 Burkitt's lymphoma cell lines (BLCL) were found to have an absent (16 lines) or decreased (8 lines) expression of vimentin IFM. In contrast, non-Burkitt's malignant lymphoid cell lines (5 lines) and lymphoblastoid cell lines (LCL) derived from normal B-cells (45 lines) exhibited a well-developed vimentin IFM network. However, low expression of vimentin was also found in 3 LCL derived from patients with the Langer-Giedion syndrome, which is characterized by a deletion of the distal end of chromosome 8. Treatment of vimentin-negative BLCL and Langer-Giedion LCL with azacytidine led to a transient reexpression of vimentin.
Highlights from Recent Cancer Literature
Journal: Cancer Research (2017)

Novel Combination Therapies in TNBCPatients with triple-negative breast cancer (TBNC) receive little benefit from cytoxic or targeted therapies currently in the clinic.To identify novel combinations beneficial to TBNC patients, Wali and colleagues evaluated 128 experimental agents for their ability to synergize with six FDA-approved drugs in reducing the viability of TNBC cell lines.While the majority of combinations were antiproliferative, only a few displayed synergy.Combinations showing this increased sensitivity were further evaluated, including comparisons of gene and protein expression.The most successful combinations included the proapoptotic drug ABT-263, the MDM2 inhibitor nutlin-3, or the bromodomain inhibitor JQ1, with paclitaxel.ABT-263 also synergized with two distinct MET inhibitors, crizotinib and XL-184, consistent with MET overexpression in TNBC patient tumors.These combinations are readily translatable for TBNC patients.(Image courtesy of Wikimedia Commons.)
Physiology and Pathology of the Cerebrospinal Fluid.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transactions of the Royal Academy of Medicine in Ireland.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Domestic Violence Intervention Calls for More Than Treating Injuries
Authors: Teri Randall
Journal: JAMA (1990)

BATTERING appears to be the single most common cause of injury to women—more common than automobile accidents, muggings, and rapes combined (Stark ED, Flitcraft A. Violence among intimates: an epidemiological review. In: Hasselt VN, et al, eds.<i>Handbook of Family Violence</i>. New York, NY: Plenum Pub Corp; 1988:293-318). While most clinicians wouldn't consider discharging a patient with a life-threatening condition, data from emergency department records show that a majority of women who are victims of domestic abuse are discharged without any arrangements made for their safety, to return to the same abusive relationships that caused their injuries (<i>Gender and Society</i>. 1989;3:506-517). Despite the widespread presence of domestic violence (see p 940) and its major role in women's health, the medical community has yet to consistently identify victims of domestic violence and extend treatment beyond the physical manifestations of an abusive relationship. Several studies have shown that 22% to 35% of
Manual of Diseases of Children.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Health Team Approach to Medical Education
Authors: John F. McCreary
Journal: JAMA (1968)

In this communication, I cannot discuss a fully formed and fully functioning system of educating all of the health professions together; however, I can relate some of the circumstances under which such an approach seemed feasible, discuss the general areas in which interprofessional education can be successfully instituted, and can say much about the problems that are associated with attempting to set up a health sciences center. It will be necessary for me to give a short description of the background of the Faculty of Medicine of the University of British Columbia in order that the situation which exists at the present time will be understood. Ours is a very young medical school, having started in 1950 in a young university in which there were no other health professional schools except the School of Nursing. The medical school was started under very much less than ideal circumstances, with temporary buildings
A Manual of Surgical Treatment.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE AMERICAN PUBLIC HEALTH ASSOCIATION.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Completeness of AIDS Case Reporting in New York City
Authors: Alan E. Greenberg
Journal: JAMA (1993)

<h3>Objective.</h3> —To assess the completeness of acquired immunodeficiency syndrome (AIDS) case reporting in New York City (NYC), and to determine whether the completeness of reporting differs in various populations. <h3>Design.</h3> —Retrospective record review of hospital laboratory logs, death certificates, hospital discharge records, and patient registries at private physicians' offices and hospital outpatient clinics. <h3>Setting.</h3> —Public and private hospitals, and private physicians' offices in NYC. <h3>Patients.</h3> —Adults and adolescents with AIDS or with illnesses suggestive of AIDS were identified using both population-based and nonrandom sampling techniques. These persons were matched with the NYC AIDS case registry, and the medical records of nonmatching persons were reviewed to determine whether they met the 1987 Centers for Disease Control and Prevention surveillance case definition for AIDS. <h3>Main Outcome Measures.</h3> —The completeness of reporting was calculated for the five individual projects and for the aggregate database by gender, race/ethnicity, risk, borough of residence, age, first AIDS diagnosis, and year of diagnosis. <h3>Results.</h3> —Of 7015 persons with AIDS identified in the five projects, 5912 (84%) had been previously reported (range, 77% to 89%). The completeness of reporting ranged from 81% to 87% in all major gender, race/ethnicity, risk, borough of residence, and age subgroups. In a multivariate analysis, the odds of being unreported were significantly higher among outpatients in hospital clinics, out-of-state residents, persons with diagnoses other than<i>Pneumocystis carinii</i>pneumonia, and persons recently diagnosed with AIDS. <h3>Conclusions.</h3> —This study indicates that the NYC AIDS surveillance system functioned effectively during the first decade of the AIDS epidemic. Completeness-of-reporting studies are an integral part of AIDS surveillance, providing data that are critical for assessing the validity of the AIDS surveillance database. (<i>JAMA</i>. 1993;269:2995-3001)
Disease in Captive Wild Mammals and Birds: Incidence, Description, Comparison.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chronic Asthma in Children
Authors: Donald D. Schwartz
Journal: JAMA (1972)

In contrast to many disease conditions that show a precipitous rise in patients over the age of 45 years, allergic disorders exert an equal impact on those under 45. Data from the National Health Survey in 1966-1967 show that, as a cause of limitation of activity in persons under 45, asthmaallergic rhinitis is second or third only to impairments of back and spine, and mental and nervous conditions.<sup>1</sup>Perhaps even more significant, asthma—allergic rhinitis was the leading cause of limitation of activity among nearly 30% of persons under age 17. Clinical forms of asthma as perceived today include allergic or spasmodic asthma, allergic asthma complicated by infection, allergic bronchopulmonary aspergillosis, infective asthma, asthma with nasal polyps and aspirin sensitivity, chronic asthma without bronchitis, chronic bronchitis with asthma, and status asthmaticus.<sup>2</sup> Despite the sophistication of this recent classification, the controversy continues whether asthma is a symptom or a disease.
Smoking and Subarachnoid Haemorrhage
Authors: A Taha, K P Ball, R D Illingworth
Journal: Journal of the Royal Society of Medicine (1982)

An enquiry was made into the smoking habits of 199 patients who had survived a subarachnoid haemorrhage (SAH). Information was obtained from 189, giving a 95% response rate. Those with a cerebral aneurysm had on average smoked considerably more cigarettes daily than those with arteriovenous malformations (AVM) or with normal angiographic findings (NAF) whose smoking habits were similar to those of the UK population. SAH due to cerebral aneurysm should be considered another smoking-related disease.
Complication of Intubation Of Gastrointestinal Tract
Authors: Robert E. Johnstone
Journal: JAMA (1972)

<h3>To the Editor.—</h3> We have recently observed a patient made cyanotic by unrecognized intubation of the left main bronchus by a Miller-Abbott tube. This complication of gastointestinal intubation is not reported in several recent reviews.<sup>1,2</sup> The patient was a 42-year-old woman with cervical carcinoma. Three days after a Wertheim hysterectomy with deep lymph-node dissection she had a schizophrenic reaction. Because she was disruptive, antipsychotic drug therapy was started and the doses were rapidly increased; by the sixth day postoperatively she was receiving haloperidol, 2 mg every eight hours, and chlorpromazine, 100 mg every six hours. Signs of a small-bowel obstruction developed and tube decompression was decided upon. Thirty minutes before attempting intubation, the patient received 10 mg of morphine which caused marked sedation and no response to verbal stimuli. As nasal passage of the Miller-Abbott tube was attempted, apnea and cyanosis developed. The tube was withdrawn. The patient coughed
The Appropriate Use of Diagnostic Imaging
Authors: Philip E. S. Palmer
Journal: JAMA (1984)

THE "RED GOGGLE" syndrome is named after the red goggles that were used for dark adaptation in the prevideo era of radiology. The clinical syndrome is well known to radiologists, but not as yet well recognized by clinicians. Such a definition is half humorous but, sadly, also half serious—serious because in whatever form it is seen, the syndrome results in much unnecessary expenditure on health care and, in diagnostic radiology departments, in excess radiation. The radiologist in red goggles preparing for fluoroscopy should have disappeared from hospitals in North America. Much else has also changed. X-ray films are no longer processed by hand, there is much better image quality, yet less radiation is needed. Ultrasound has altered obstetrical knowledge and practice, interventional radiology is contributing to treatment, computed tomography (CT) has taken radiology toward tissue differentiation, and now magnetic resonance imaging and positron emission tomography permit the study of tissue
Uncommon Breast Tumor Attenuation Artifact on Radionuclide Ventriculography
Authors: Gilles Metrard, Stéphane Giraud, O. Capitain, Christian Jeanguillaume, H. Rakotonirina, C. Berthelot, J.J. Le Jeune, O. Morel
Journal: Clinical Nuclear Medicine (2008)

A 39-year-old woman with locally advanced left breast cancer (T4 N0 M0) underwent equilibrium radionuclide ventriculography for baseline assessment of left ventricular function before neoadjuvant chemotherapy. The left ventricular ejection fraction was 76% at 75 beats per minute, without localized wall motion abnormality. In the best septal left anterior oblique projection, a large photopenic “halo” surrounded the cardiac chambers, mimicking a pericardial effusion. In fact, this aspect resulted from an attenuation artifact by a large left breast tumor, as demonstrated by FDG-PET/CT imaging.