tbuckley/cabot-search huggingface dataset:
The bronchodilator effects of aerosolized terbutaline. A controlled, double-blind study
Authors: B. F. Bachus
Journal: JAMA (1977)

The bronchodilator effects of aerosols of a high-dose of terbutaline sulfate (1.5 mg), a low-dose of terbutaline sulfate (0.75 mg), isoproterenol (0.3 mg), and placebo were compared using forced expiratory spirometry, flow-volume curves, and body plethysmography in a double-blind, six-hour, controlled study in 25 patients with reversible airflow obstruction. After isoproterenol therapy, the values peaked at 15 minutes, and none were significantly different (<i>P</i>&lt;.05) from placebo after the 30-minute observation point. The values for high-dose terbutaline peaked at one hour at a level that exceeded responses to isoproterenol. All values except the forced vital capacity at five and six hours and functional residual capacity at six hours were significantly greater than placebo (<i>P</i>&lt;.05) at all observation points. The low-dose terbutaline values peaked earlier and at a lower value than the high-dose terbutaline values, and several indexes were significantly greater (<i>P</i>&lt;.05) than after isoproterenol therapy beyond the two-hour point. (<i>JAMA</i>238:2277-2281, 1977)
The Smoke Problem
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening for Diabetes Mellitus
Authors: Mayer B. Davidson
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 January 1989Screening for Diabetes MellitusMayer B. Davidson, MDMayer B. Davidson, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-2-168_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the 15 October issue, Singer and colleagues recommend that patients not be screened for type 2 diabetes. They argue that there is no convincing evidence that therapy can ameliorate or prevent chronic complications and that therapy begun when the patient is asymptomatic is no more effective than therapy begun after diabetes causes symptoms.We need to address the questions of complications and control more critically than simply referring to the (largely discredited) University Group Diabetes Program study: "Complications" need to be separated into those that are macrovascular, for which the evidence is poor that glucose control...References1. MikiFukudaKuzuya EMT. Relation of the course of retinopathy to control of diabetes, age, and therapeutic agents in diabetic Japanese patients. Diabetes. 1969;18:773-80. CrossrefMedlineGoogle Scholar2. Pirart J. Diabetes mellitus and its degenerative complications: a prospective study of 4,400 patients observed between 1947 and 1973. Diabetes Care. 1978;1:168-88. CrossrefGoogle Scholar3. Dahl-JörgensenBrinchmann-HansenHanssen KOK. Effect of near normoglycaemia for two years on progression of early diabetic retinopathy, nephropathy, and neuropathy: the Oslo study. Br Med J. 1986;293:1195-9. CrossrefMedlineGoogle Scholar4. TakazakuraNakamotoHayakawa EYH. Onset and progression of diabetic glomerulosclerosis: a prospective study based on serial renal biopsies. Diabetes. 1975;24:1-9. CrossrefMedlineGoogle Scholar5. Feldt-RasmussenMathiesenDeckert BET. Effect of two years of strict metabolic control on progression of incipient nephropathy in insulin-dependent diabetes. Lancet. 1986;2:1300-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cedars-Sinai Medical Center Los Angeles, CA 90048-1869 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrimary prevention of Type 2 (non-insulin-dependent) diabetes mellitus 15 January 1989Volume 110, Issue 2Page: 168-168KeywordsDiabetes mellitusGlucoseType 2 diabetes Issue Published: 15 January 1989 PDF downloadLoading ...
Prolonged Weakness and Vecuronium
Authors: Rodger E. Barnette
Journal: Annals of Internal Medicine (1993)

Letters1 April 1993Prolonged Weakness and VecuroniumRodger E. Barnette, MD and Christer Carlsson, MDRodger E. Barnette, MDSearch for more papers by this author and Christer Carlsson, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-7-199304010-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:As Kupfer and colleagues [1] note, most patients in the intensive care unit do not require complete neuromuscular blockade. Their statement, however, that a 75% blockade is usually sufficient and that the degree of blockade should be monitored bears comment.Neuromuscular function is usually evaluated in the intensive care unit by the response of the adductor pollicis brevis muscle (adduction of thumb) to percutaneous supramaximal stimulation of the ulnar nerve, using skin electrodes placed at the wrist and connected to a peripheral nerve stimulator. The ratio of a single twitch to that of a control twitch reflects ...References1. Kupfer Y, Namba T, Kaldawi E, Tessler S. Prolonged weakness after long-term infusion of vecuronium bromide. Ann Intern Med. 1992; 117:484-6. Google Scholar2. Lee CM. Train of four quantitation of competitive neuromuscular blockade. Anesth Analg. 1975; 54:649-53. Google Scholar3. Paton ED, Waud DR. The margin of safety of neuromuscular transmission. J Physiol (Lond). 1967; 191:59-90. Google Scholar4. Mogensen V. Neuromuscular monitoring. In: Miller RD; ed. Anesthesia. 3rd edition. New York: Churchill Livingstone; 1209-26. Google Scholar5. Fiamengo SA, Savarese JJ. Use of muscle relaxants in intensive care units. Crit Care Med. 1991; 19:1457-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiseases of the Peripheral Nervous System 1 April 1993Volume 118, Issue 7Page: 569-571KeywordsAcetylcholineCritical careDrugsIntensive care unitsMusclesNervesNeuromuscular blockadeParalysisSafetySafety studies ePublished: 15 August 2000 Issue Published: 1 April 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
"Kissing Bug" Bite in Los Angeles
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An outbreak of organic dust toxic syndrome in a college fraternity
Authors: W. T. Brinton
Journal: JAMA (1987)

An explosive outbreak of a febrile respiratory illness occurred among members of a college fraternity. The preponderant signs and symptoms were muscle aches, cough, and low-grade fever. All illnesses occurred within 1.3 to 13 hours of attendance at a party where there was a dense airborne dust from straw that had been laid on the floor. Of the 67 fraternity members who attended the party and answered a questionnaire, 55 became ill (attack rate, 82%). Risk of illness was higher for those who spent more time at the party. Duration of illness ranged from 4.5 hours to seven days. Results of serological studies did not demonstrate an allergic or viral cause for these illnesses. The clinical and epidemiologic features of this outbreak were characteristic of organic dust toxic syndrome, an acute respiratory illness caused by inhalation of molds growing on hay, silage, or other agricultural products. (<i>JAMA</i>1987;258:1210-1212)
P3-233: Risk factors for recurrence and unfavorable prognosis in patients with stage IA non-small-cell lung cancer and a tumor diameter of 20mm or less
Authors: Naruyuki Kobayashi, Shinichi Toyooka, Junichi Soh, Koichi Ichimura, Hiroyuki Yanai, Hiroshi Suehisa, Masaomi Yamane, Takahiro Oto, Yoshihumi Sano, Hiroshi Date
Journal: Journal of Thoracic Oncology (2007)
Drosophila As a Model System for Molecular Analysis of Tumorigenesis
Authors: Bernard M. Mechler, Dennis Strand, Andreas Kalmes, Reinhard Merz, Martina Schmidt, Istvan Torok
Journal: Environmental Health Perspectives (1991)

In Drosophila, homozygous mutations in a series of genes can cause the appearance of tissue-specific tumors. These tumors occur either during embryonic or larval development. The majority of the identified genes give rise to larval tumors that affect either the presumptive adult optic centers of the brain, the imaginal discs, the hematopoietic organs, or the germ cells. These genes act as recessive determinants of neoplasia and have been designated as tumor-suppressor genes. They are normally required for the regulation of cell proliferation and cell differentiation during development. Among these genes, the lethal(2)giant larvae (l(2)gl) has been best studied. Homozygous mutations in l(2)gl produce malignant tumors in the brain hemispheres and the imaginal discs. The l(2)gl gene has been cloned, introduced back into the genome of l(2)gl-deficient animals, and shown to restore normal development. The nucleotide sequence of the l(2)gl gene has been determined, as well as the sequence of its transcripts. Anti-l(2)gl antibodies recognize a protein of about 130 kDa that corresponds to the major product of l(2)gl transcripts. Analysis of the spatial distribution of l(2)gl transcripts and proteins revealed a first phase of intensive expression during embryogenesis and a second weaker phase during the larval to pupal transition period. As revealed by mosaic experiments, the critical period of l(2)gl expression for preventing tumorigenesis takes place during early embryogenesis. During this period, the l(2)gl protein is ubiquitously expressed in all cells and tissues, while during late embryogenesis expression becomes gradually restricted to the midgut epithelium and the axon projections of the ventral nervous system that show no phenotypic alteration in the mutant animals.(ABSTRACT TRUNCATED AT 250 WORDS)
Abstract 181A: PIN1 and FOXP3 regulate SKP2 expression
Authors: Wei-Hsiung Yang, Chiung-Min Wang, William H. Yang
Journal: Cancer Research (2019)

Abstract S-phase kinase-associated protein 2 (SKP2), a component of the E3 ubiquitin ligase SKP1-CUL1-Fbox complex, acts as an oncogene/oncoprotein as evidence suggests that overexpression of SKP2 results in cell cycle dysregulation and tumorigenesis as well as associates with poor prognosis in numerous cancers. The unique peptidyl-propyl isomerase PIN1, which isomerizes the cis-trans peptide bond between pSer/pThr and proline, regulates its target proteins’ cell localization, stability, and function. However, whether SKP2 is the target protein of PIN1 remains unknown. Herein, we demonstrate that SKP2 expression is regulated by PIN1 and FOXP3. First, we observed that knock-down PIN1 using siRNAs reduced SKP2 protein level in several cancer cell lines (MCF7, PC3, DU145, HepG2, and JEG3 cells). Secondly, we found that overexpression of PIN1 increased SKP2 protein level. Furthermore, PIN1 dose-dependently enhanced SKP2 promoter activity in gene reporter assay. Since FOXP3 is a known transcriptional repressor for the oncogene SKP2, we investigated whether PIN1 affects FOXP3-mediated SKP2 expression. Interestingly, we observed that PIN1 dose-dependently counteracted FOXP3-mediated SKP2 promoter activity. Finally, we demonstrated that mutations on PIN1 (W34A) and FOXP3 (Y342F) abolished PIN1-mediated and FOXP3-mediated SKP2 expression, respectively. Taken together, our results suggest that PIN1 functions as a novel regulator of SKP2 and with FOXP3 may be involved in tumor development and progression. Citation Format: Wei-Hsiung Yang, Chiung-Min Wang, William H. Yang. PIN1 and FOXP3 regulate SKP2 expression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 181A.
Clinical guidelines
Authors: G A C MAJOR
Journal: Annals of the Rheumatic Diseases (1998)

<b>Introduction</b> It has been found an increased risk of asthma up to 4 times higher in patients with rhinitis, especially if it is allergic rhinitis. <b>Objetive</b> We aimed to study predictive factors of asthma in patients with rhinitis. <b>Methodology</b> It has been monitored for more than 10 years a total of 639 patients diagnosed in the first revision of rhinitis and bronchial asthma (RBA), rhinitis without asthma (R) and bronchial asthma without rhinitis (BA). After more than 10 years since diagnosis, we contacted by telephone with all patients to have a follow questionnaire for symptoms of rhinitis and / or bronchial asthma. Those patients with a history of just rhinitis were cited and reviewed looking for a possible diagnosis of asthma too. We collected clinical data,presence of atopy ( total and specific IgE and prick test study), degree of current asthma control, respiratory function, inflammation study (exhaled FeNO), methacholine challenge test or mannitol if it was necessary. Statistical analysis was performed using logistic regression using the step wise method, analyzing all the parameters included in the first review. <b>Results</b> The current average age of patients was 40.3 (±13 ) years. At the initial visit 354 patients (55.4 %) had RBA, 259 (40.5 %) R and 26 (4.1 %) BA. 37.1% of patients with rhinitis suffer from asthma at the end. In the logistic regression analysis we found that the predictors factors for asthma were family history of asthma, history of childhood infection and atopy. <b>Conclusions</b> In our serie, 37 % of patients with rinhitis suffer from asthma when we follow-up over 10 years. We identified as predictors factors for asthma a family history of asthma, childhood infections and atopy .
Archiv und Atlas der normalen und pathologischen Anatomie in typischen Röntgenbildern. Die Differentialdiagnose der Wirbelsäulentuberkulose
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Untersuchungsmethoden für Arzneispezialitäten
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
“The effect of exacerbation history on outcomes in the IMPACT trial.” David M.G. Halpin, Mark T. Dransfield, MeiLan K. Han, C. Elaine Jones, Sally Kilbride, Peter Lange, David A. Lipson, David A. Lomas, Fernando J. Martinez, Steve Pascoe, Dave Singh, Robert Wise and Gerard J. Criner. Eur Respir J 2020; 55: 1901921.
Journal: European Respiratory Journal (2020)

In the paragraph of the Methods section relating to patients, the range of values for the COPD Assessment Test scores was erroneously reported to be 0-400, and not the correct 0-40.The relevant sentence should correctly state: "Enrolled patients were aged ⩾40 years with symptomatic COPD: COPD Assessment Test score ⩾10 (range 0-40), with higher scores indicating more symptoms; minimal clinically important difference (MCID) two units.
Correction
Journal: BMJ (1931)

BRITlRNof albumin, the specific gravity being usually 1010.The heart is somewhat enlarged, and the first sound at the apex is duplicated.Treatment already tried has included nitroglycerin, mannitol nitrate, asthnmatic mixtures of all kinds, and thyroid gland tablets.Lately she has had liquor morphinae at night and a mixture of tincture of digitalis and potassium bromide during the day.This had some success for a time.Some temporary relief is obtained by taking a half-grain tablet of ephedrine hydrochloride during the attack.
Environmental Factors Altering Thyroid Function and Their Assessment
Authors: Charles P. Barsano
Journal: Environmental Health Perspectives (1981)

Chronic ingestion of modest doses of dietary iodine, radiation, and polyhalogenated biphenyls (PCB's and PBB's) are environmental factors with known or suspected adverse effects on the human thyroid. Iodine consumption in the United States is approaching 1 mg daily for a large segment of the population. Data are reviewed which support the need for concern regarding the long-term adverse effects of dietary iodine on thyroid function, particularly in certain susceptible individuals. Environmental sources of radiation pose a significant risk of thyroid cancer and hypothyroidism under certain circumstances which may be intentional, inadvertent, or accidental. Exposure to polyhalogenated biphenyls during manufacture or as industrial pollutants are hazardous to man and to wildlife in moderate or large quantities and perhaps also in small amounts. The need to investigate the potential harm posed by these factors in the quantities commonly encountered is emphasized.
儿科异位性皮炎中的金黄色葡萄球菌IgG抗体
Authors: J.E.E. Totte, L.M. Pardo, K.B. Fieten, J. de Wit, D.V. de Boer, W.J. van Wamel, S.G.M.A. Pasmans
Journal: British Journal of Dermatology (2018)

本研究由来自荷兰和瑞士的团队开展,旨在探索异位性湿疹患者产生被称为IgG的抗体类型与对抗金黄色葡萄球菌这类细菌的组成部分的关系。金黄色葡萄球菌常见于患有异位性湿疹的儿童和成人皮肤中,主要是通过刺激免疫系统或引起对细菌本身的过敏反应导致病情恶化。在本研究中,研究人员观察了异位性湿疹患者存在对抗不同细菌组成部分的IgG类抗体的情况,然后将其与疾病严重程度进行了对比。他们发现,抗体能对抗细菌产物(有时称为毒力因子),而细菌产物涉及到减少正常免疫反应,与疾病加重有关。在本研究中,破坏人类白细胞的某种蛋白质就是降低免疫力的细菌产物的一个示例。这表明这些降低免疫力的组成部分也可能通过延长有机体在皮肤表面的寿命成为加重湿疹的因素,这也从另一个角度解释了为何应在患有湿疹的皮肤上减少或全部去除金黄色葡萄球菌这类细菌。
Lipoprotein(a)
Authors: Angelo M. Scanu
Journal: JAMA (1992)

Lipoprotein(a) (Lp[a]) can be defined as a lipoprotein particle having as a protein moiety apolipoprotein B-100 (the protein associated with low-density lipoprotein) disulfide-linked to apolipoprotein(a), the distinctive glycoprotein of Lp(a) that is homologous to plasminogen. Several forms of Lp(a) occur in the circulation. This polymorphism is related to the apolipoprotein(a) size heterogeneity that is controlled by the several alleles of the apolipoprotein(a) gene. High plasma levels of Lp(a) have been correlated with an increased risk for atherothrombotic cardiovascular disease by a mechanism that is as yet undefined. Pathogenicity may also derive from Lp(a) particles that have been modified by events believed to occur when Lp(a), after traversing the artery endothelium, reaches the intima. Aside from several promising leads, there are no universally accepted ways to lower high plasma Lp(a) levels. At this time, it is best to target efforts toward the modifiable risk factors by using appropriate diets and exercise programs and, whenever necessary, drug therapy. (<i>JAMA</i>. 1992;267:3326-3329)
Intermediate coronary care units
Authors: L. Resnekov
Journal: JAMA (1977)

CORONARY care units have functioned since 1962,<sup>1</sup>and despite some contrary views,<sup>2</sup>most physicians agree that they reduce the mortality from acute myocardial infarction if the patient survives long enough to be admitted. The mortality during the later in-hospital phase following acute myocardial infarction may, however, be as high as that within the unit itself,<sup>3</sup>and, in consequence, Gotsman and Shrire<sup>4</sup>proposed setting up an intermediate coronary care unit (ICCU) to provide the patient continued and progressive coronary care after he had left the coronary care unit (CCU). By 1971 Grace and Yarvote<sup>5</sup>began routinely monitoring patients beyond the fifth hospital day in a specially equipped and staffed area separate from the CCU, and Whipple et al<sup>6</sup>were also early in developing dedicated units of this type. It seems reasonable, therefore, that when considering appropriate management for patients suffering coronary heart disease, we should