tbuckley/cabot-search huggingface dataset:
Endoscopic ultrasonography
Authors: M. Polkowski
Journal: Endoscopy (2007)

A computer search of the PubMed database (see appendix for search strategy) revealed a total of 255 papers devoted to endoscopic ultrasonography (EUS) that were published in English between August 2006 and mid-August 2007. These included 121 original papers (47 %), 78 case reports, comments, or letters (31 %), and 56 reviews or editorials (22 %). Both the numbers and breakdown of original papers by topic area and publishing journal ([Fig. 1]) are almost identical to those reported in a similar review 2 years ago [1]. It seems as though the research on EUS has reached a plateau.
Cystathioninuria
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thomas Young, F.R.S.: Philosopher and Physician
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Roads Taken
Authors: Walden S. Morton
Journal: Annals of Internal Medicine (1996)

Ad Libitum15 November 1996Roads TakenWalden S. MortonWalden S. MortonCape Elizabeth, ME 04107.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-10-199611150-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail My eldest and I went up together to the Maine campalong the lake. Wisps of red-gold curlsblew across her brow, covering the frown of anticipation.Aspens drooped in the summer heat as she unloadedboots and jodphurs for the first job as camp counselor.Her tears gathered,so I drove away, wavingout the windowonly to receive theknifefive milesdown the roadin the sandbeside thetar.from the ... Author, Article, and Disclosure InformationAffiliations: Cape Elizabeth, ME 04107. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1996Volume 125, Issue 10Page: 857KeywordsCyclic adenosine monophosphateElbow Issue Published: 15 November 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
RESPONSE: A randomized, open label, phase III study of INC424 in polycythemia vera (PV) patients resistant to or intolerant of hydroxyurea (HU).
Authors: S. Verstovsek, J. Kiladjian, R. J. Waltzman, V. Sandor, J. Lukawy, W. M. Garrett, K. Malek, R. M. Huber, A. M. Vannucchi
Journal: Journal of Clinical Oncology (2011)

TPS203 Background: PV is a myeloproliferative neoplasm characterized by clonal stem cell proliferation causing increased red cell mass, blood hyperviscosity, significant morbidity, shortened lifespan and possible evolution to acute myeloid leukemia. Splenomegaly, debilitating symptoms, leukocytosis, and thrombocytosis are common in advanced disease. HU, an established first-line agent for cytoreduction, can be associated with cytopenias, aphthous and leg ulcers and other side effects. Control of hematocrit is not always achieved with HU and many patients are either intolerant of or become resistant to HU; second line therapeutic options are limited with no drugs approved in this setting. Janus kinase (JAK) 2 plays a key role in the pathophysiology of PV; nearly 100% of patients harbor either the JAK2V617F gain-of-function mutation or a JAK2 exon 12 mutation. In a phase II study in HU-resistant or -intolerant PV patients, INC424, a potent and selective inhibitor of JAK1 and JAK2, was well tolerated and achieved rapid and durable clinical responses including phlebotomy independence, resolution of splenomegaly, and improvements in white blood cell counts, platelet counts, and disease-related symptoms (Verstovsek S, et al. at 52nd ASH Annual Meeting; December 4–7, 2010. #313). Methods: RESPONSE, a global, open-label phase III trial (NCT01243944), is designed to compare the efficacy and safety of INC424 to Best Available Therapy (BAT) in adult patients with PV who are resistant to or intolerant of HU (by ELN criteria), require phlebotomy due to inadequate hematocrit control, and exhibit palpable splenomegaly ≥ 5 cm below the costal margin with either leukocytosis > 15 x 109/L and/or thrombocytosis > 600 x 109/L. The primary efficacy endpoint, assessed after 32 weeks of treatment, is based on achieving both phlebotomy independence and a ≥ 35% reduction in spleen volume as measured by imaging. All patients will be treated for 80 weeks to assess safety and response durability. Patients randomized to BAT may be eligible to cross over to receive INC424 after week 32. Enrollment is now open globally with a target of 300 patients to be randomized 1:1 to INC424 or BAT.
Computer-based case tracing (COMTRAC)
Authors: E. F. Osserman
Journal: JAMA (1978)

To assist clinical assessment and decision making, a computer-based system has been developed to organize key data of individual medical records and display these data in a standard graphic format for each disease. A program for multiple myeloma has been completed and 150 case records entered. The data accessed by computer-based case tracing on all cases of a particular disease are available for cumulative and comparative analyses of different therapeutic regimens. (<i>JAMA</i>239:1772-1776, 1978)
Abstract 1296: Arylsulfonamide KCN1 suppresses primary and metastatic growth of uveal melanoma through anti-angiogenic and anti-invasion mechanisms
Authors: Stefan Kaluz, Qing Zhang, Hua Yang, Satoru Osuka, Jiyoung Mun, Narra S. Devi, Mark Goodman, Hans E. Grossniklaus, Erwin G. Van Meir
Journal: Cancer Research (2019)

Abstract Uveal melanoma (UM) is the most prevalent primary intraocular malignancy in adults with a survival time less than 1 year for patients that develop metastases (about 50%). HIF-1 plays a critical role in UM adaptation to the hypoxic microenvironment, treatment failure, and metastasis. In this study, we evaluated biodistribution and anti-cancer efficacy of arylsulfonamide KCN1, a lead compound in a novel class of small-molecule inhibitors of the hypoxia-inducible factor (HIF-1) pathway in UM models. PET with 11C-labeled KCN1 showed that KCN1 preferentially localizes to the eye and liver, the organ where UM preferentially metastasizes. In survival studies, UM cells were injected into the suprachoroidal space of the right murine eye using a transscleral technique and the eye was enucleated 7-9 days post-inoculation. Starting on Day 1, KCN1 or vehicle only (cremophor EL/ethanol 1:1, diluted with sterile PBS 1:5) were administered daily i.p., 5 x week, until animals reached the endpoint. Main organs were collected and evaluated for metastatic load. We found that KCN1 potently inhibited the growth of primary eye tumors, VEGF expression, angiogenesis in the primary tumor, the number and size of hepatic metastases, and extended mice survival. KCN1 inhibited invasion of UM cells in in vitromodels, such as scratch-wound and Boyden chamber migration assays. To identify possible mediators of hypoxia-HIF-induced metastatic processes inhibited by KCN1 in UM, we tested a series of 20 candidates by qRT-PCR. Among the most consistently HIF-induced/KCN1-inhibited genes were prolyl-4-hydroxylases P4HA1 and 2 that modulate physical properties of the tumor microenvironment by post-translationally modifying collagen. Expression of P4HA1 and 2 is significantly higher in UM patients with metastatic disease and high level of expression correlates with poor prognosis. In summary, our studies suggest KCN1 exerts anti UM activity by inhibiting the primary tumor growth, reducing vascular density in the primary tumor, and the number and size of the hepatic metastases; KCN1 has therefore therapeutic potential for treatment of UM and further clinical development. Citation Format: Stefan Kaluz, Qing Zhang, Hua Yang, Satoru Osuka, Jiyoung Mun, Narra S. Devi, Mark Goodman, Hans E. Grossniklaus, Erwin G. Van Meir. Arylsulfonamide KCN1 suppresses primary and metastatic growth of uveal melanoma through anti-angiogenic and anti-invasion mechanisms [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1296.
Optic neuropathy in relapsing polychondritis
Authors: P. J. Killian
Journal: JAMA (1978)

RELAPSING polychondritis is a rare disorder of uncertain origin characterized by recurrent inflammation of cartilaginous structures throughout the body. An increased awareness has resulted in more frequent reporting of this condition in recent years. Ocular involvement occurs in 65% of patients with relapsing polychondritis.<sup>1</sup>Episcleritis is the most common ocular finding, although scleritis, conjuctivitis, iritis, and keratitis are frequently found. Rarely, chorioretinitis, exophthalmos, extraocular muscle palsies, and optic neuritis may be encountered. We report the case of a 63-year-old man with relapsing polychondritis in whom ischemic optic neuropathy developed. <h3>Report of a Case</h3> A 63-year-old man noted the rapid onset of decreased vision in his left eye. He also complained of shoulder girdle myalgias. He was seen at a nearby emergency room, was thought to have unilateral papilledema, and was transferred to Walter Reed Army Medical Center. Initial examination showed that his visual acuity was 20/20 in the right
Diabetes mellitus in Eskimos after a decade
Authors: G. J. Mouratoff
Journal: JAMA (1973)

Although clinical diabetes mellitus is still rare, more Eskimos were intolerant of glucose in 1972 than was true ten years earlier. Also, a higher proportion of the population was overweight. The high tolerance for glucose in these people does not appear to have a genetic basis, but may instead be associated with physical activity and physical fitness.
Intact Implicit Learning in Schizophrenia
Authors: J.-M. Danion
Journal: American Journal of Psychiatry (2001)

OBJECTIVE: Schizophrenia impairs performance on explicit, but not implicit, memory tasks, indicating that conscious awareness at retrieval is a critical determinant of impaired memory. The authors investigated implicit learning, i.e., knowledge acquisition in the absence of conscious awareness, in patients with schizophrenia. METHOD: An artificial grammar learning task was used to assess implicit learning in 48 patients with schizophrenia and 24 healthy comparison subjects. The subjects were first presented with letter strings that were generated according to the rules of a finite-state grammar paradigm. They were then required to indicate whether new letter strings were “grammatical,” depending on whether or not the strings corresponded to the rules. IQ, working memory, explicit memory, verbal fluency, and speed of processing were also assessed. RESULTS: Patients performed significantly worse than the comparison subjects on cognitive tasks that assessed episodic memory, verbal fluency, working memory, and speed of processing. In contrast, patients classified as being correct more grammatical than nongrammatical letter strings, and the magnitude of the difference was similar to that observed in healthy comparison subjects. CONCLUSIONS: Implicit learning, as assessed with an artificial grammar learning task, is intact in patients with schizophrenia. Conscious awareness might be a critical determinant of memory impairment both at encoding and at retrieval.
ECHOES OF THE ROTATING HEART
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COPPER SULPHATE AND WATER PURIFICATION.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
International Union of Pharmacology. XL. Compendium of Voltage-Gated Ion Channels: Calcium Channels
Authors: William A. Catterall, Joerg Striessnig, Terrance P. Snutch, Edward Perez-Reyes
Journal: Pharmacological Reviews (2003)

This summary article presents an overview of the molecular relationships among the voltage-gated calcium channels and a standard nomenclature for them, which is derived from the <i>IUPHAR Compendium of Voltage-Gated Ion Channels.</i>1 The complete Compendium, including data tables for each member of the calcium channel family can be found at http://www.iuphar-db.org/iuphar-ic/.
Cancer genetics evaluation: Barriers to and improvements for referral
Authors: R. Brandt, Z. Ali, A. Sabel-Soteres, P. Gilman
Journal: Journal of Clinical Oncology (2005)

6109 Background: Cancer susceptibility testing is now an integral part of cancer risk management. Little information exists regarding physicians’ selection and referral of eligible patients. This study’s purpose was to understand who, why and when physicians refer and to assess comfort with this role. Methods: A survey was sent to 243 physicians identified by specialty as potential referrers to a local cancer genetics program to assess prior awareness of and referral to the program, factors used to determine eligibility, and comfort level identifying suitable patients and discussing genetics. Data analysis was performed using chi-square and independent samples t-tests. Results: The survey was completed by 82 physicians (34%). Only 59% reported program awareness and of these, 80% had previously referred (p<0.0001). Awareness was greater among oncologists, surgeons and gynecologists than primary care physicians (PCP) (p<0.0001). Patients were referred for enhanced risk assessment (88%), improved medical management (85%), and concern for family members (83%). Physicians based eligibility on family (96%) or patient (83%) cancer history or on patient request (73%). Only 37% of physicians inquired about ethnicity. Patients were not referred due to patient disinterest (54%) or physician concern about insurance coverage (44%) or discrimination (31%). Of gynecologists, 73% did not refer patients if too old. Of PCP’s, 25% did not refer already affected patients. The mean comfort score for identifying eligible patients was 3.7 and for discussing genetics was 3.5. PCP’s were less comfortable with identification (p<0.0001) and discussion (p<0.002) than specialists. Previous referrers were more comfortable identifying suitable patients (p=0.03). Physicians noted cancer genetics education (67%) and program brochures in exam rooms (60%) may improve the referral process. Conclusions: The largest barriers to referral were lack of program awareness, confusion about patient eligibility and limited knowledge about insurance coverage and anti-discrimination legislation. Physician-targeted marketing, education highlighting patient selection and insurance issues, and brochures in exam rooms may improve physician comfort and referrals. No significant financial relationships to disclose.
The Journal’s Appreciation
Authors: Alexander Moreira-Almeida, Francisco Lotufo Neto, Bruce Greyson, Charles M. Beasley Jr., James D. Wines Jr., Roy N. Tamura, Roy H. Perlis, Tanja M. Brückl, Hans-Ulrich Wittchen, Giovanni A. Fava, Jenny Guidi, Lutz Wittmann, Michael Schredl, Milton Kramer, Michael Höfler, Hildegard Pfister, Silvia Schneider, Roselind Lieb, Harrison G. Pope Jr., J. Alexander Bodkin, James. I. Hudson, Steven Barry, David Cohen, Stephen Joseph, Cristina Cusin, Deborah Shear, Jay Amsterdam, Frederick Quitkin, Robert E. Strong, Jerrold F. Rosenbaum, Maurizio Fava, Carol D. Ryff, Burton Singer, Silvia Schneider, Peter J. Veldhuizen, Tina In-Albon
Journal: Psychotherapy and Psychosomatics (2006)
Remembrance
Authors: Corina L. Iacopetti
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Handbuch der normalen und pathologischen Physiologie mit Berücksichtigung der experimentellen Pharmakologie.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physician Must Empathize With Athlete
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal