tbuckley/cabot-search huggingface dataset:
Biosynthesis of Dimethylnitrosamine in Dimethylamine-Treated Mice After Exposure to Nitrogen Dioxide&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1981)

These studies demonstrate the nitrosatihg potential of NO2 in vivo in ICR mice. Groups of mice were gavaged with 2 mg dimethylamine (DMA) and exposed to NO2 at levels from 0.04 to 44.5 ppm for periods up to 4 hours. Mice were individually frozen and blended to a powder, aliquots of which were homogenized in ice-cold dicholoromethane and 35% aqueous methanol. Concentrates of organic extracts were analyzed for dimethylnitrosamine (DMN) by a Thermal Energy Analyzer with a gas Chromatograph interface. Biosynthesis of DMN was dose- and time-dependent with relation to NO2 exposure, reaching a maximum yield of 60–70 ng/mouse (0.0034% DMA conversion) at 2 hours. DMN biosynthesis was inhibited by sodium ascorbate and, more effectively, by ammonium sulfamate.
Chemotherapy for Lung Cancer by Intra-aortic Infusion
Authors: Herman A. Freckman
Journal: JAMA (1966)

Over a period of four years, 91 patients with inoperable or nonresectable lung cancer (55 bronchogenic and 36 metastatic) were treated by the continuous regional intra-aortic infusion of fluorouracil and cyclophosphamide, or both, for the purpose of increasing and prolonging the concentration of these agents in tumor-bearing areas supplied by the bronchial arteries. Twelve of the patients with bronchogenic cancer showed an objective response rate of 12.4 months' duration with an average survival time of 13.4 months. In the metastatic group, the cancers of 12 patients had an average objective regression of 12.5 months' duration with an average survival time of 14.5 months. A comparable retrospective study of the intravenous method of administration demonstrated no objective response (by our criteria) in 49 cases of bronchogenic and seven cases of metastatic lung cancer. Average survival time was 4.2 and 4.4 months, respectively.
Mitochondrial DNA Studies Help Identify Lost Victims of Human Rights Abuses
Authors: Andrew A. Skolnick
Journal: JAMA (1993)

MITOCHONDRIAL DNA (mtDNA) extracted from the teeth and bones buried in clandestine graves is allowing investigators to identify victims of government-sanctioned murder in several countries. By comparing mtDNA sequences of possible living relatives with DNA extracted from teeth found in two mass graves in Guatemala, T. Christian Boles, PhD, assistant professor of biochemistry, Brandeis University, Waltham, Mass, is helping forensic anthropologists confirm the identities of five of the victims. The skeletons are believed to be the remains of 12 men who were taken from the village of San Jose Pachó Lemoa by a "civilian patrol" the night of February 14, 1982. The next morning, villagers found what appeared to be two freshly dug graves in a nearby ravine. For more than 10 years after the massacre, the villagers did not disturb the graves, nor did they talk about the disappearance of the men or the gunshots they heard during that
Prostatectomy and Survival Among Men With Clinically Localized Prostate Cancer
Authors: Gilbert Lawrence
Journal: JAMA (1996)

<h3>To the Editor.</h3> —In the pooled analysis of radical prostatectomy among 2758 men at 8 major universities in United States and Europe, the authors reported high 10-year diseasespecific survival rates in all tumor grades.<sup>1</sup>However, a closer look at this extensive study permits us to understand the behavior of the tumor and improve the outcome of the most common cancer in men. At 10 years, prostate cancer deaths in grades 1, 2, and 3 were 6%, 20%, and 23% and metastases were seen in 13%, 32%, and 48%, respectively. The data cannot be improved by "watchful waiting." The results suggest patients with grades 2 and 3 disease need postoperative therapy or an alternative treatment approach. The fact that these patients are poor candidates for surveillance is conceded even by its proponents. Results for patients with grade 1 tumors at 10 years are good. Low-grade tumors have a low mitotic index—ie, few mitotic
Consensus on the Key Characteristics of Immunotoxic Agents as a Basis for Hazard Identification
Authors: Dori R. Germolec, Herve Lebrec, Stacey E. Anderson, Gary R. Burleson, Andres Cardenas, Emanuela Corsini, Sarah E. Elmore, Barbara L.F. Kaplan, B. Paige Lawrence, Geniece M. Lehmann, Curtis C. Maier, Cliona M. McHale, L. Peyton Myers, Marc Pallardy, Andrew A. Rooney, Lauren Zeise, Luoping Zhang, Martyn T. Smith
Journal: Environmental Health Perspectives (2022)

Background: Key characteristics (KCs), properties of agents or exposures that confer potential hazard, have been developed for carcinogens and other toxicant classes. KCs have been used in the systematic assessment of hazards and to identify assay and data gaps that limit screening and risk assessment. Many of the mechanisms through which pharmaceuticals and occupational or environmental agents modulate immune function are well recognized. Thus KCs could be identified for immunoactive substances and applied to improve hazard assessment of immunodulatory agents. Objectives: The goal was to generate a consensus-based synthesis of scientific evidence describing the KCs of agents known to cause immunotoxicity and potential applications, such as assays to measure the KCs. Methods: A committee of 18 experts with diverse specialties identified 10 KCs of immunotoxic agents, namely, 1) covalently binds to proteins to form novel antigens, 2) affects antigen processing and presentation, 3) alters immune cell signaling, 4) alters immune cell proliferation, 5) modifies cellular differentiation, 6) alters immune cell–cell communication, 7) alters effector function of specific cell types, 8) alters immune cell trafficking, 9) alters cell death processes, and 10) breaks down immune tolerance. The group considered how these KCs could influence immune processes and contribute to hypersensitivity, inappropriate enhancement, immunosuppression, or autoimmunity. Discussion: KCs can be used to improve efforts to identify agents that cause immunotoxicity via one or more mechanisms, to develop better testing and biomarker approaches to evaluate immunotoxicity, and to enable a more comprehensive and mechanistic understanding of adverse effects of exposures on the immune system. https://doi.org/10.1289/EHP10800
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance
Authors: Lige Leng, Ziqi Yuan, Ruiyuan Pan, Xiao Su, Han Wang, Jin Xue, Kai Zhuang, Ju Gao, Zhenlei Chen, Hui Lin, Wenting Xie, Huifang Li, Zhenyi Chen, Keke Ren, Xiao Zhang, Wenting Wang, Zi-Bing Jin, Shengxi Wu, Xinglong Wang, Zengqiang Yuan, Huaxi Xu, Hei-Man Chow, Jie Zhang
Journal: Nature Metabolism (2022)
Safety, immunogenicity and antibody persistence of a bivalent Beta-containing booster vaccine against COVID-19: a phase 2/3 trial
Authors: Spyros Chalkias, Frank Eder, Brandon Essink, Shishir Khetan, Biliana Nestorova, Jing Feng, Xing Chen, Ying Chang, Honghong Zhou, David Montefiori, Darin K. Edwards, Bethany Girard, Rolando Pajon, Frank J. Dutko, Brett Leav, Stephen R. Walsh, Lindsey R. Baden, Jacqueline M. Miller, Rituparna Das
Journal: Nature Medicine (2022)

Updated immunization strategies are needed to address multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. Here we report interim results from an ongoing, open-label phase 2/3 trial evaluating the safety and immunogenicity of the bivalent Coronavirus Disease 2019 (COVID-19) vaccine candidate mRNA-1273.211, which contains equal mRNA amounts encoding the ancestral SARS-CoV-2 and Beta variant spike proteins, as 50-µg (n = 300) and 100-µg (n = 595) first booster doses administered approximately 8.7-9.7 months after the mRNA-1273 primary vaccine series ( NCT04927065 ). The primary objectives were to evaluate the safety and reactogenicity of mRNA-1273.211 and to demonstrate non-inferior antibody responses compared to the mRNA-1273 100-µg primary series. Additionally, a pre-specified immunogenicity objective was to demonstrate superior antibody responses compared to the previously authorized mRNA-1273 50-µg booster. The mRNA-1273.211 booster doses (50-µg or 100-µg) 28 days after immunization elicited higher neutralizing antibody responses against the ancestral SARS-CoV-2 and Beta variant than those elicited 28 days after the second mRNA‑1273 dose of the primary series ( NCT04470427 ). Antibody responses 28 days and 180 days after the 50-µg mRNA-1273.211 booster dose were also higher than those after a 50-µg mRNA-1273 booster dose ( NCT04405076 ) against the ancestral SARS-CoV-2 and Beta, Omicron BA.1 and Delta variants, and all pre-specified immunogenicity objectives were met. The safety and reactogenicity profile of the bivalent mRNA-1273.211 booster (50-µg) was similar to the booster dose of mRNA-1273 (50-µg). Immunization with the primary series does not set a ceiling to the neutralizing antibody response, and a booster dose of the bivalent vaccine elicits a robust response with titers that are likely to be protective against COVID-19. These results indicate that bivalent booster vaccines can induce potent, durable and broad antibody responses against multiple variants, providing a new tool in response to emerging variants.
RAD21 amplification epigenetically suppresses interferon signaling to promote immune evasion in ovarian cancer
Authors: Peng Deng, Zining Wang, Jinghong Chen, Shini Liu, Xiaosai Yao, Shaoyan Liu, Lizhen Liu, Zhaoliang Yu, Yulin Huang, Zhongtang Xiong, Rong Xiao, Jiuping Gao, Weiting Liang, Jieping Chen, Hui Liu, Jing Han Hong, Jason Yongsheng Chan, Peiyong Guan, Jianfeng Chen, Yali Wang, Jiaxin Yin, Jundong Li, Min Zheng, Chao Zhang, Penghui Zhou, Tiebang Kang, Bin Tean Teh, Qiang Yu, Zhixiang Zuo, Qingping Jiang, Jihong Liu, Ying Xiong, Xiaojun Xia, Jing Tan
Journal: Journal of Clinical Investigation (2022)

Prevalent copy number alteration is the most prominent genetic characteristic associated with ovarian cancer (OV) development, but its role in immune evasion has not been fully elucidated. In this study, we identified RAD21, a key component of the cohesin complex, as a frequently amplified oncogene that could modulate immune response in OV. Through interrogating the RAD21-regulated transcriptional program, we found that RAD21 directly interacts with YAP/TEAD4 transcriptional corepressors and recruits the NuRD complex to suppress interferon (IFN) signaling. In multiple clinical cohorts, RAD21 overexpression is inversely correlated with IFN signature gene expression in OV. We further demonstrated in murine syngeneic tumor models that RAD21 ablation potentiated anti-PD-1 efficacy with increased intratumoral CD8+ T cell effector activity. Our study identifies a RAD21-YAP/TEAD4-NuRD corepressor complex in immune modulation, and thus provides a potential target and biomarker for precision immunotherapy in OV.
Skin chronological aging drives age-related bone loss via secretion of cystatin-A
Authors: Wenquan Liang, Qingjing Chen, Shasha Cheng, Ruiming Wei, Yuejun Li, Chenfeng Yao, Zhicong Ouyang, Dawei Kang, Ajuan Chen, Zezheng Liu, Kai Li, Xiaochun Bai, Qingchu Li, Bin Huang
Journal: Nature Aging (2022)
Space-time-regulated imaging analyzer for smart coagulation diagnosis
Authors: Longfei Chen, Le Yu, Yantong Liu, Hongshan Xu, Linlu Ma, Pengfu Tian, Jiaomeng Zhu, Fang Wang, Kezhen Yi, Hui Xiao, Fuling Zhou, Yi Yang, Yanxiang Cheng, Long Bai, Fubing Wang, Yimin Zhu
Journal: Cell Reports Medicine (2022)

The development of intelligent blood coagulation diagnoses is awaited to meet the current need for large clinical time-sensitive caseloads due to its efficient and automated diagnoses. Herein, a method is reported and validated to realize it through artificial intelligence (AI)-assisted optical clotting biophysics (OCB) properties identification. The image differential calculation is used for precise acquisition of OCB properties with elimination of initial differences, and the strategy of space-time regulation allows on-demand space time OCB properties identification and enables diverse blood function diagnoses. The integrated applications of smartphones and cloud computing offer a user-friendly automated analysis for accurate and convenient diagnoses. The prospective assays of clinical cases (n = 41) show that the system realizes 97.6%, 95.1%, and 100% accuracy for coagulation factors, fibrinogen function, and comprehensive blood coagulation diagnoses, respectively. This method should enable more low-cost and convenient diagnoses and provide a path for potential diagnostic-markers finding.
Sexual Dysfunction in the United States—Reply
Authors: Raymond C. Rosen, Edward O. Laumann, Anthony Paik
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the Centers for Disease Control. Healthy people 2000: national health promotion, disease prevention objectives for the year 2000
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Die Blutkrankheiten in der Praxis.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
National Concern About Drug Abuse Brings Athletes Under Unusual Scrutiny
Authors: Virginia Cowart
Journal: JAMA (1986)

WHEN UNIVERSITY of Maryland basketball star Len Bias began celebrating his selection as a member of the Boston Celtics professional basketball team on June 17—an ultimate celebration that would end with his death, attributed to cocaine intoxication, early on June 19—there were at least four reports of heart damage or death due to cocaine use in the medical literature of the previous six months (<i>Arch Pathol Lab Med</i>1986;110:479-484,<i>Am J Cardiol</i>1986;57:1185-1186 and 57:496,<i>Am Heart J</i>1986;111:793). The sympathomimetic and vasoconstrictive effects of cocaine may induce tachycardia, hypertension, or coronary artery spasm in some users, resulting in myocardial infarction, arrhythmias, or even sudden cardiac death. In addition, a few people are hypersensitive to even small amounts of cocaine because of a congenital deficiency in the ability of the blood and liver esterases to metabolize the drug. As little as 20 mg can be fatal, although the lethal dose
Abdominal Binding During Cardiopulmonary Resuscitation
Authors: Ionel BUCUR
Journal: JAMA (1982)

<h3>To the Editor—</h3> Dr Chandra and colleagues conclude in their article "Abdominal Binding During Cardiopulmonary Resuscitation in Man" (1981; 246:351) that one of the reasons for the BP improvement in the patients in their study probably was a decrease in arterial perfusion in the abdomen and in the lower extremities. There are reasons to believe that this effect probably was one of the most important factors for the distinct hemodynamic effect in their study. In 1975, Dr Worsvorda and I1 studied the effect of external mechanical cardiac massage combined with ventilation and mechanical compression of the abdominal aorta using an automatic unit. The study subjects were ten patients experiencing cardiac arrest, and the systolic BP measured in the brachial arteries increased from 70.9 to 103.0 mm Hg (mean value for ten patients,<i>P</i>&lt;.05) when the automatic unit was used. The mechanical device for aortic compression was placed over the
N-Nitrosation of Proline in Smokers and Nonsmokers&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Ladd, Kenneth F., Newmark, Harold L., Archer, Michael C.
Journal: JNCI Journal of the National Cancer Institute (1984)

N-Nitrosation of Proline in Smokers and Nonsmokers Kenneth F. Ladd, Kenneth F. Ladd 4Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, 500 Sherbourne St., Toronto, Canada M4X 1K9.5Recipient of a studentship from the Province of Ontario. Search for other works by this author on: Oxford Academic PubMed Google Scholar Harold L. Newmark, Harold L. Newmark 6Ludwig Institute for Cancer Research, Toronto Branch, 9 Earl St., Toronto, Canada M4Y 1M4. Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael C. Archer Michael C. Archer 7 4Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, 500 Sherbourne St., Toronto, Canada M4X 1K9. 7Address reprint requests to Dr. Archer. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 73, Issue 1, July 1984, Pages 83–87, https://doi.org/10.1093/jnci/73.1.83 Published: 01 July 1984 Article history Received: 22 November 1983 Accepted: 21 February 1984 Published: 01 July 1984
Erythema Nodosum Treatment With Colchicine
Authors: Stanley L. Wallace
Journal: JAMA (1967)

<h3>To the Editor:—</h3> We recently reported our experience with the diagnostic use of colchicine (<b>199</b>:525, 1967). In this paper, we described one patient with erythema nodosum and arthritis who had a dramatic improvement in her joint manifestations and a gradual clearing of the nodose skin lesions after receiving colchicine. A much earlier record of the benefit in erythema nodosum to be obtained with colchicine has come to our attention. John Elliotson, MD, FRS, Professor of Principles and Practice of Medicine at the University of London, delivered a clinical lecture on erythema on Jan 16, 1832, which was subsequently published in Lancet.<sup>1</sup>Dr. Elliotson, after describing erythema nodosum, recommended elevation of the legs, bleeding, and purging as therapy. "The best internal medicine is colchicum." It is clear that he considered colchicum's effect as that of a superior purgative. If colchicum is taken "until it purges briskly, the disease rapidly
Municipal Drinking Water and Cardiovascular Death Rates
Authors: Henry A. Schroeder
Journal: JAMA (1966)

The association of the degree of softness of municipal water and death rates from hypertensive and arteriosclerotic heart diseases, demonstrated for 1949 to 1951 rates, persisted in 1960. Statistical analyses of death rates from 88 cities of the United States with levels of bulk and trace elements in municipal water supplies showed negative correlations for 12 major and 4 trace constituents. The purer the water in terms of dissolved elements, the higher was the death rate from this cause. No trace element of 19 measured was found highly correlated. One possible explanation of this phenomenon involves the corrosive quality of soft water for metal pipes in dwellings.
Highlights of This Issue
Journal: Clinical Cancer Research (2011)

Several pathogenic mechanisms of EBV-associated extranodal NK/T cell lymphoma (NKTL) have been suggested, including microRNAmedicated oncogenesis.In this study, Paik and colleagues investigated the role of miR-146a in NKTL.Using human tissues and cell lines, they found that miR-146a functioned as a tumor suppressor, through downregulation of the TNF receptor-associated factor-6 (TRAF6)/NFκB pathway.The expression level of miR-146a was also found to have prognostic significance in NKTL.These observations provide new insight into the pathogenesis of NKTL and suggest that miR-146a is a useful prognostic factor and a potential therapeutic target in this disease. Highlights
The Technic of Local Anesthesia.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal