Vitamin D and Risk for Type 2 Diabetes in People With Prediabetes
Authors: Jacob M. Hands, Rhonda Patrick, Leigh A. Frame
Journal: Annals of Internal Medicine (2023)

LettersAugust 2023Vitamin D and Risk for Type 2 Diabetes in People With PrediabetesJacob M. Hands, BA, Rhonda Patrick, PhD, Leigh A. Frame, PhDJacob M. Hands, BAThe George Washington University School of Medicine, Washington, DCSearch for more papers by this author, Rhonda Patrick, PhDFoundMyFitness, San Diego, CaliforniaSearch for more papers by this author, Leigh A. Frame, PhDThe George Washington University School of Medicine, Washington, DCSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L23-0201 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR: Pittas and colleagues' systematic review and meta-analysis (1) showed that higher-dose oral vitamin D supplementation is associated with a reduced risk for type 2 diabetes mellitus (T2DM). Of interest, the authors report that this effect may be greater in “leaner” persons, especially those with a body mass index less than 31.3 kg/m2. To explain this variance, they chiefly speculate that obesity suppresses the activation of key cytochrome P450s (CYPs)—namely, CYP2R1 and CYP27B1—which jointly function to endogenously convert vitamin D3 into its biologically active form, 1,25-dihydroxyvitamin D3. Although this analysis from Pittas and colleagues is thoughtful, the explanation ...References1. Pittas AG, Kawahara T, Jorde R, et al. Vitamin D and risk for type 2 diabetes in people with prediabetes. A systematic review and meta-analysis of individual participant data from 3 randomized clinical trials. Ann Intern Med. 2023;176:355-363. [PMID: 36745886] doi:10.7326/M22-3018 LinkGoogle Scholar2. Turner R, Stratton I, Horton V, et al. UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK Prospective Diabetes Study Group. Lancet. 1997;350:1288-93. [PMID: 9357409] CrossrefMedlineGoogle Scholar3. Zinman B, Kahn SE, Haffner SM, et al; ADOPT Study Group. Phenotypic characteristics of GAD antibody-positive recently diagnosed patients with type 2 diabetes in North America and Europe. Diabetes. 2004;53:3193-200. [PMID: 15561950] CrossrefMedlineGoogle Scholar4. Hjort R, Ahlqvist E, Carlsson PO, et al. Overweight, obesity and the risk of LADA: results from a Swedish case-control study and the Norwegian HUNT Study. Diabetologia. 2018;61:1333-1343. [PMID: 29589073] doi:10.1007/s00125-018-4596-0 CrossrefMedlineGoogle Scholar5. Gabbay MA, Sato MN, Finazzo C, et al. Effect of cholecalciferol as adjunctive therapy with insulin on protective immunologic profile and decline of residual β-cell function in new-onset type 1 diabetes mellitus. Arch Pediatr Adolesc Med. 2012;166:601-7. [PMID: 22751874] doi:10.1001/archpediatrics.2012.164 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Jacob M. Hands, BA; Rhonda Patrick, PhD; Leigh A. Frame, PhDAffiliations: The George Washington University School of Medicine, Washington, DCFoundMyFitness, San Diego, CaliforniaDisclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L23-0201. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoVitamin D and Risk for Type 2 Diabetes in People With Prediabetes Anastassios G. Pittas , Tetsuya Kawahara , Rolf Jorde , Bess Dawson-Hughes , Ellen M. Vickery , Edith Angellotti , Jason Nelson , Thomas A. Trikalinos , and Ethan M. Balk Vitamin D and Risk for Type 2 Diabetes in People With Prediabetes Anastassios G. Pittas , Tetsuya Kawahara , Rolf Jorde , Bess Dawson-Hughes , Ethan M. Balk Metrics August 2023Volume 176, Issue 8KeywordsDiabetes preventionGlucose intoleranceType 2 diabetesVitamin D ePublished: 15 August 2023 Issue Published: August 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...