tbuckley/cabot-search huggingface dataset:
POS1146 LOW MOLECULAR WEIGHT HEPARINS INTERFERE WITH NEUTROPHIL ACTIVATION AND NET GENERATION IN HIGH-RISK PREGNANT PATIENTS WITH ANTIPHOSPHOLIPID SYNDROME
Authors: P. Rovere-Querini, V. Canti, A. D’angelo, M. T. Castiglioni, S. Rosa, E. Manfredi, B. Frascella, V. D’alberti, A. Manfredi, N. Maugeri
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Neutrophil activation and the generation of neutrophils extracellular traps (NETs) contribute to vascular damage and thrombosis in antiphospholipid syndrome (aPS). We reported that Low molecular weight heparin (LMWH) prevent neutrophil activation induced by P-selectin expressed by activated platelets [1, 2] and jeopardize in healthy subjects the ability of neutrophils to generate NETs and to mobilize granule contents [3]. <h3>Objectives</h3> To investigate whether LMWH, used on empirical bases to in high-risk patients, regulate neutrophil/platelet interaction in pregnant women. <h3>Methods</h3> Here we report preliminary data from a prospective monocentric study in which the activation of platelets and neutrophils was assessed in sixteen pregnant women treated with LMWHs, with or without aPS at 12, 24 and 32 weeks of gestation. Patients were studied again when feasible after pregnancy completion. Sixteen healthy pregnant women, ten healthy women outside pregnancy and ten women with Systemic Lupus Erythematosus outside pregnancy served as controls. <h3>Results</h3> Platelets of pregnant healthy women were activated, as assessed by the increased expression of P-selectin and tissue factor. All patients successfully completed the pregnancy. Abnormalities were evident at the pathological assessment of the placentae despite the treatment with LMWHs. The treatment was associated with significantly reduced: i) platelet/neutrophil interaction, as assessed by heterotypic aggregates; ii) neutrophil expression of tissue factor; iii) platelet expression of the prototypic DAMP, HMGB1; iv) accumulation in the blood of byproducts of NET formation/catabolism, such as myeloperoxidase-DNA complexes. P-selectin expression was, in contrast, unaffected. <h3>Conclusion</h3> The results indicate that neutrophil and platelet activation/interaction, which may reflect detrimental intravascular immune events leading to pregnancy complications, abate in patients treated with LMWHs. <h3>References</h3> [1]Maugeri N et al. Prevention of platelet-polymorphonuclear leukocyte interactions: new clues to the antithrombotic properties of parnaparin, a low molecular weight heparin. Haematologica. 2005; 90(6):833-9. [2]Maugeri N et al. Parnaparin, a low-molecular-weight heparin, prevents P-selectin-dependent formation of platelet-leukocyte aggregates in human whole blood. Thromb Haemost. 2007 Jun;97(6):965-73. doi: 10.1160/th06-12-0680. [3]Manfredi AA et al. Low molecular weight heparins prevent the induction of autophagy of activated neutrophils and the formation of neutrophil extracellular traps. Pharmacol Res. 2017 Sep;123:146-156. doi: 10.1016/j.phrs.2016.08.008 <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1195 KNEE OSTEOARTHRITIS AND NEUROPATHIC PAIN: IMPACT OF RADIOGRAPHIC SEVERITY
Authors: H. Fouzia, F. Z. Taik, I. Berrichi, N. Soba, M. Fourtassi, F. E. Abourazzak
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Pain in knee osteoarthritis remains the main symptomatology, classically considered as nociceptive. A neuropathic component of this pain has recently been described. The identification of which is essential for adequate management. <h3>Objectives</h3> The objective of our study is to evaluate the relationship between the prevalence of neuropathic pain and the stages of radiographic severity in gonarthrosis. <h3>Methods</h3> This is a descriptive cross-sectional study of patients with clinically and radiographically retained knee osteoarthritis. The radiographic stage was determined by the Kellgren and Lawrence classification. Neuropathic pain was assessed by the DN4 questionnaire. The neuropathic nature of the pain was retained if the DN4&gt;=4. The patients included were divided into 4 groups according to the radiographic stage. <h3>Results</h3> 173 patients were included. The average age was 58.0±9.19 years. 88.2% were women. 32.7% of patients had neuropathic pain. Average pain VAS was 4.4±2.1. The median duration of evolution was 3.8 years[1-23]. 5.6%, 64.4%, 25.6%, and 4.4%, of the patients studied were classified by radiography as caution, 1, 2, 3, and 4 respectively. The prevalence of neuropathic pain was 16.6%, 34.4%, 35.5% and 33.3% in patients with radiographic severity grade 1, 2, 3, and 4 respectively. When comparing the groups, there was no difference in the DN4 score according to the stage of radiographic severity (p=0.633). <h3>Conclusion</h3> The results of our study suggest that the stage of radiographic severity does not predispose to neuropathic pain in patients with gonarthrosis. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB0751 AXIAL SPONDYLOARTHRITIS IN PATIENTS WITH GASTROINTESTINAL INVOLVEMENT OF BEHÇET SYNDROME
Authors: M. Ozturk, S. N. Esatoglu, I. Hatemi, A. F. Celik, E. Yilmaz, D. Ucar, M. Melikoglu, H. Yazici, G. Hatemi
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Despite attempts to lump Behçet syndrome (BS) with spondyloarthritides, controlled studies have shown that radiographic sacroiliitis is not increased in BS (BS). However, gastrointestinal involvement of Behçet syndrome (GIBS) shares common features with inflammatory bowel disease which, in turn, can be associated with spondyloarthritis. <h3>Objectives</h3> We wanted to test whether GIBS patients have an increased frequency of radiographic sacroiliitis or non-radiographic axial spondyloarthropathy (nr-AxSpA) compared to BS patients without major organ involvement who have only mucocutaneous and/or joint involvement. <h3>Methods</h3> We included 67 GIBS patients and 55 consecutive BS patients without major organ involvement. Patients were screened for axial spondyloarthritis (axSpA) using the Assessment of Spondyloarthritis International Society (ASAS) criteria. First they were questioned for chronic back pain, defined by ASAS as the presence of chronic back pain for more than 3 months with an age at onset of &lt;45 years. Patients with chronic back pain were questioned for other spondyloarthritis features and underwent HLA-B27 testing, C-reactive protein testing, and X-ray and magnetic resonance imaging of the sacroiliac joints. <h3>Results</h3> Chronic back pain was reported by 24 (35%) GIBS patients and 16 (29%) BS patients without major organ involvement. Eight (12%) GIBS patients and 4 (7%) controls met ASAS criteria for axSpA (p=0.39). Four (6%) GIBS patients and 1 (2%) patient in the control group had radiographic axSpA (also termed ankylosing spondylitis), whereas 4 GIBS patients and 3 patients among the controls had nr-AxSpA. HLA B27 was positive in 2 (8%) of the GIBS patients and in 3 (19%) of the controls (p=0.33) (Table 1). <h3>Conclusion</h3> There was some, statistically insignificant increase in the frequency of axSpA among the GIBS patients. While the frequency of ankylosing spondylitis was consistent with previous studies, the frequency of axSpA according to the more recent ASAS criteria was found in 9.8% of the total group of BS patients. To the best of our knowledge ASAS criteria have not previously been tested in BS. They, perhaps need to be studied in a larger group of BS patients, including those with acne associated arthritis- previously shown to be associated with enthesitis (1) - together with healthy and diseased controls. <h3>References</h3> [1]Hatemi G, Fresko I, Tascilar K, Yazici H. Increased enthesopathy among Behçet's syndrome patients with acne and arthritis: an ultrasonography study. Arthritis Rheum. 2008 May;58(5):1539-45. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
POS1553 THE SIGNIFICANT ASSOCIATION OF HLA-A26 WITH UVEITIS AND GASTROINTESTINAL INVOLVEMENT IN PATIENTS WITH BEHÇET’S DISEASE IN A MULTICENTER STUDY
Authors: T. Nakajima, H. Tsuji, R. Inaba, R. Saito, K. Nishimura, A. Morinobu
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Specific haplotypes of human leukocyte antigen (HLA) are associated with susceptibility and disease activity of Behçet's disease (BD). However, the clinical importance of HLA-A26 in BD is not well recognized compared to that of HLA-B51. <h3>Objectives</h3> This study aimed to examine the association between HLA-A26, HLA-B51, clinical manifestations, and disease severity in BD, especially focusing on HLA-A26 possession. <h3>Methods</h3> This study was a multicenter cross-sectional observational study and patients with BD were enrolled from 2006 to 2021. All patients met the International Criteria for BD [1] or the diagnostic criteria of the Behçet's Disease Research Committee of Japan [2]. Disease severity was evaluated using Krause score reflecting the entire spectrum of disease manifestations [3]. Both serotypes and genotypes were accepted for HLA typing. <h3>Results</h3> In total, 200 patients were enrolled in this study. Uveitis was observed in 95/196 patients (48.5%) and gastrointestinal involvement in 57/167 patients (34.1%). HLA haplotypes were identified for HLA-B51 (n = 52/106, 49.1%), HLA-A26 (n = 25/88, 28.4%), and both HLA-B51 and HLA-A26 (n = 6/88, 6.8%). While HLA-A26 showed no significant association with clinical manifestations without adjustment for HLA-B51, HLA-A26 possession showed a higher frequency of uveitis (HLA-A26 positive vs. negative: n = 6/6, 100% vs. n = 16/32, 50.0%, respectively, p = 0.03) and higher Krause scores (median: 7 vs. 5, respectively, p = 0.02) under conditions with HLA-B51. Furthermore, the association between uveitis and gastrointestinal involvement was influenced by HLA-A26: HLA-A26 possession was associated with a higher frequency of uveitis in patients with gastrointestinal involvement (HLA-A26 positive vs. negative: n = 5/9, 55.6% vs. n = 0/21, 0%, respectively, p = 0.001), as well as for gastrointestinal involvement in patients with uveitis (HLA-A26 positive vs. negative: n = 5/11, 45.5% vs. n = 0/24, 0%, respectively, p = 0.001). All 5 patients with both uveitis and gastrointestinal involvement had HLA-A26 (HLA-A26 positive vs. negative: n = 5/21, 23.8% vs. n = 0/58, 0%, respectively, p = 0.001). <h3>Conclusion</h3> HLA-A26 was associated with severity of BD and uveitis in patients with HLA-B51, and was associated with coexistence of uveitis and gastrointestinal involvement. This study suggested the importance of confirming HLA-A haplotype in patients with BD. <h3>References</h3> [1]J Eur Acad Dermatol Venereol. 2014; 28(3): 338-47. [2]Y Mizushima, G Inaba, Y Mimura. Report of Behçet's Disease Research Committee, Japan; 1987. 8-17. [3]I Krause, et al. J Rheumatol. 2001; 28(5): 1033-6. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
POS1584-HPR IMPACT OF TELEMEDICINE ON DISEASE ACTIVITY ASSESSMENT: A CASE-CROSS OVER NESTED WITHIN A COHORT OF SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS
Authors: I. Almaghlouth, H. Almalag, H. Alzuhair, A. Bedaiwi, L. Hassen, S. Alzomia, B. Alanazi, S. Alahmari, K. N. Asfina, N. Khalil, M. A. Omair, M. Bedaiwi
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> The utilization of telemedicine has been rapidly growing among patients with rheumatic disease especially following COVID-19 pandemic. The ease and convenience seems to dominate the reasons of such growth. Yet the effect of this approach on patients with systemic lupus erythematosus (SLE) is yet to be revealed. <h3>Objectives</h3> In this study, we aimed to examine the effect of telemedicine in SLE patients on the outcome of disease activity. <h3>Methods</h3> This is a case-cross over study nested within the national prospective cohort of SLE, Saudi Arabia. SLE patients who fulfils the SLICC classification criteria within the period between March 2020 to March 2021 and have been assessed at three-time point with three months' time difference between assessments according to standardized protocol were included. Telemedicine was conducted at first point while in person assessment were used for second and third points. Primary outcome was difference in SLEDAI-2K score. Primary analysis was conducted using GEE model and adjusted for potential confounders including demographics, medications and changes in steroid doses. Several sensitivity analyses were conducted to mitigate selection and time varying confounders. <h3>Results</h3> A total of 92 participants were included. Majority of them were females (88%), with a mean (±SD) age of 36 (±13). mean (±SD) disease activity scores at baseline as follows: SLEDI 5 (±5); SRI 3.8 (±3.5); SDI 1 (±1). Mean difference of SLEDI score of -1.641 (95% CI -2.773 ─ -0.510), p=0.005* between telemedicine and follow up visits. Adjusted value and mean with mean diffrence in Figure 1. Results were consistent in all sensitivity analyses. <h3>Conclusion</h3> We found that the Telemedicine assessment was associated with much higher disease activity score compared to in person in subsequent assessments which may suggest potentially overestimation of disease activity and later assessment accuracy. Cautious adoption is suggested in SLE patients with active disease. <h3>References</h3> [1]Anderson JT, Bouchacourt LM, Sussman KL, Bright LF, Wilcox GB. Telehealth adoption during the COVID-19 pandemic: A social media textual and network analysis. Digit Health. 2022 Mar 31;8:20552076221090041. doi: 10.1177/20552076221090041. PMID: 35392254; PMCID: PMC8979849. [2]Tang, W., Inzerillo, S., Weiner, J., Khalili, L., Barasch, J., Gartshteyn, Y., Dall'Era, M., Aranow, C., Mackay, M.C., &amp; Askanase, A.D. (2022). The Impact of Telemedicine on Rheumatology Care. Frontiers in Medicine, 9. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB0189 THE BEST CARDIOVASCULAR RISK ALGORITHM FOR PREDICTING THE PRESENCE OF CAROTID PLAQUE IN WOMEN WITH RHEUMATOID ARTHRITIS
Authors: I. J. Colunga-Pedraza, J. R. Azpiri-López, D. Á. Galarza-Delgado, V. Gonzalez-Gonzalez, V. M. Beltran-Aguilar, A. G. Arias Peralta, N. De Avila Gonzalez, J. A. Cardenas-de la Garza, G. García-Arellano
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Atherosclerotic cardiovascular disease is the leading cause of death in patients with rheumatoid arthritis (RA). Chronic inflammation increases cardiovascular risk (CVR) in these patients [1]. Heart disease remains the most likely cause of death for women, and a higher risk is established than for men [2]. <h3>Objectives</h3> To compare six CVR algorithms with carotid ultrasound findings in women with RA and to identify the algorithm with the cutoff point with the best sensitivity for carotid plaque (CP) detection. <h3>Methods</h3> Cross-sectional, and descriptive study. Patients aged 40 to 75 years who met the ACR/EULAR 2010 classification criteria for the diagnosis of RA. Patients with a history of cardiovascular disease were excluded. CVR was calculated using 6 algorithms: ACC/AHA 2013, FRS-Lipids, FRS-BMI, RRS, QRISK3 and SCORE2. Carotid ultrasound was performed on all study participants, and the presence of CP, defined as diffuse carotid intima-media thickness (cIMT) ≥1.2 mm or focal thickness ≥0.5 mm, was assessed. Subclinical atherosclerosis was defined as the presence of CP or a cIMT ≥0.8mm. An ROC curve analysis was performed and the cutoff points for each algorithm were determined using the Youden index. Area under the curve (AUC) sensitivity, specificity, and likelihood ratios (LR) were calculated. A value of <i>p≤</i>0.05 was considered statistically significant. <h3>Results</h3> A total of 158 women with a diagnosis of RA were included. The prevalence of CP was 32.3%. Results are shown in Figure 1. <h3>Conclusion</h3> The FRS-Lipids algorithm was one of the best algorithms for the detection of CP in women, with the best sensitivity compared to the other algorithms, however, in the low-risk group none of the algorithms proved to be sufficiently effective in predicting CVR. Therefore, we suggest to consider carotid ultrasound as part of the evaluation in women with RA. <h3>References</h3> [1]Solomon DH, Karlson EW, Rimm EB, Cannuscio CC, Mandl LA, Manson JAE, et al. Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis. Circulation. 2003;107(9):1303–7. [2]Kurmann RD, Mankad R. Atherosclerotic vascular disease in the autoimmune rheumatologic woman, Clin Cardiol. 2018;41(2):258-263. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB0541 EFFICACY OF DISEASE-MODIFYING ANTIRHEUMATIC DRUGS IN PRIMARY SJÖGREN’S SYNDROME-RELATED INTERSTITIAL LUNG DISEASE
Authors: F. Erbasan, T. S. Öğüt, M. Dibil, M. Nokay, M. E. Terzioğlu, V. Yazisiz
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Primary Sjögren's syndrome (pSS) is mainly characterized by dry mouth and eyes due to loss of secretory function of exocrine glands, and systemic involvement can be seen [1]. One of the most important causes of morbidity and mortality in pSS is interstitial lung disease (ILD) [2]. Primary SS-related ILD (pSS-ILD) treatment is usually based on the clinician's experiences since there are insufficient clinical studies. <h3>Objectives</h3> To evaluate the treatment modalities applied to patients with pSS-ILD and the functional response to the treatment. <h3>Methods</h3> A retrospective analysis was performed, of patients with pSS-ILD, who received conventional or biological disease-modifying antirheumatic drugs between January 2004 and August 2022. Forced vital capacity (FVC%) and diffusing capacity of carbon monoxide (DLCO%) performed within 1 month before treatment and within 1 month after treatment cessation, were analyzed. The effects of DMARDs on pulmonary function and whether there was a difference in their effectiveness were evaluated. <h3>Results</h3> The prevalence of pSS-ILD was 7.2%. The mean age of 27 patients included in the study was 62.6±10.8, and 20 (74.1%) of the patients were female. Among all DMARDs (19/47) and first-line treatments (16/27), AZA was the most frequently used agent. Other agents used were MMF (n=11), RTX (n=8), CyC (n=5), and MTX (n=4). There was an increase in FVC% (from 80.20±22.1 to 81.6±23.0) and FEV1% (from 73.8±20.6 to 75.3±22.8) and a decrease in DLCO% (from 53.7±15.3 to 52.2±19.3) with DMARDs treatment, but the difference was not statistically significant (p=0.434, p=0.463, and p=0.652, respectively). There was a statistically non-significant decrease in %FVC with AZA and an increase with MMF, RTX, and CyC (Table 1). Also, there was no significant change in DLCO% values with AZA, MMF, and RTX (Table 1). The HRCT patterns were UIP in 13 (48.1%) patients, NSIP in 9 (33.3%), LIP in 2 (7.4%), and unclassified in 3 (11.1%). There were no significant differences in FVC% and DLCO% parameters with DMARDs treatment in patients with UIP and NSIP patterns. <h3>Conclusion</h3> DMARDs can stabilize pulmonary functions and delay worsening in patients with pSS-ILD. <h3>References</h3> [1]Mariette, X. &amp; Criswell, L. A. Primary Sjögren's syndrome. N. Engl. J. Med. 378, 931–939 (2018). doi: 10.1056/NEJMcp1702514. [2]Sambataro G, Ferro F, Orlandi M, Sambataro D, Torrisi SE, Quartuccio L, et al. Clinical, morphological features and prognostic factors associated with interstitial lung disease in primary Sjögren's syndrome: A systematic review from the Italian Society of Rheumatology. Autoimmun Rev. 2020;19:102447. doi: 10.1016/j.autrev.2019.102447. <h3>Disclosure of Interests</h3> None Declared. <h3>Disclosure of Interests</h3> None Declared.
POS1347 EVALUATING THE EFFICACY OF LOCAL CORTICOSTEROID INJECTION, PLATELET-RICH PLASMA, AND EXTRACORPOREAL SHOCKWAVE THERAPY IN PATIENTS WITH PES ANSERINE BURSITIS: A PILOT RANDOMIZED, COMPARATIVE CLINICAL TRIAL
Authors: W. A. Gouda, A. S. Abbas, T. M. Abdel-Aziz, M. Z. Shoaeir, A. Moshrif, A. Mosallam
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Pes anserine bursitis is one of the causes of painful knee syndromes. It limits physical activity and impairs the quality of life of a patient. Obesity and osteoarthritis (OA) of the knee are common predisposing factors for pes anserine bursitis. It is treated with non-steroidal anti-inflammatory drugs (NSAIDs), physiotherapy, injections of local anesthetics, and corticosteroids. This study examines the efficacy of local corticosteroid injection, Platelet-rich plasma (PRP) injection, and extracorporeal shock wave therapy (ESWT) as different modalities to alleviate pain and improve function in patients with pes anserine bursitis. <h3>Objectives</h3> This study examines the efficacy of local corticosteroid injection, Platelet-rich plasma (PRP) injection, and extracorporeal shock wave therapy (ESWT) as different modalities to alleviate pain and improve function in patients with pes anserine bursitis. <h3>Methods</h3> This randomized comparative clinical trial was performed between July 2021 and June 2022 in the rheumatology and rehabilitation department at Al-Azhar University hospitals in Egypt on 180 patients diagnosed with chronic pes anserine bursitis according to Larson and Baum criteria. The enrolled patients were divided into three groups, each including sixty patients. Group I received a local corticosteroid injection of 40 mg of methylprednisolone acetate/1 ml (n = 60); Group II received a PRP injection (n = 60); and in Group III, ESWT (n = 60) was used. The Visual Analog Scale (VAS), Western Ontario and McMaster Universities (WOMAC) pain score, WOMAC physical function score, and Ritchie score for tenderness were recorded at the baseline, after 1 week, and after 8 weeks. <h3>Results</h3> There are significant differences between the corticosteroid group compared to the PRP group (10.6± 2.5) and the ESWT group (9.7 ±2.6) regarding the WOMAC pain score and WOMAC physical function score one week after the application of procedures. There is a highly statistically significant (p= 0.001) decreased 8-week WOMAC pain score in the corticosteroid group (5.7 ± 2.7) when compared to the PRP group (9.4± 2.4) and ESWT group (7.1± 1.5) <b>Table [1].</b> As regards VAS, there isn't a statistically significant difference (p = 0.636) between the studied groups as regards baseline VAS or 8-week VAS after the procedure. <h3>Conclusion</h3> An examination of Pes anserine bursitis is essential and shouldn't be missed in knee OA patients complaining of pain. Our findings show that local corticosteroid injection is more effective than PRP injection and ESWT for pain relief. <h3>Declarations</h3> The authors declare that they have no competing interests. <h3>Disclosure of Interests</h3> None Declared.