Highlighted research articles
Journal: Cancer Discovery (2023)

In This Issue| June 02 2023 Highlighted research articles Author & Article Information Online ISSN: 2159-8290 Print ISSN: 2159-8274 ©2023 American Association for Cancer Research2023American Association for Cancer Research Cancer Discov (2023) 13 (6): 1275–1277. https://doi.org/10.1158/2159-8290.CD-13-6-ITI Related Content This is a related article to: Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors This is a related article to: A Transcriptome-Based Precision Oncology Platform for Patient–Therapy Alignment in a Diverse Set of Treatment-Resistant Malignancies This is a related article to: Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways View more This is a related article to: Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax This is a related article to: (R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers This is a related article to: Single-Cell RNA Sequencing Unifies Developmental Programs of Esophageal and Gastric Intestinal Metaplasia This is a related article to: p38MAPKα Stromal Reprogramming Sensitizes Metastatic Breast Cancer to Immunotherapy This is a related article to: Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions This is a related article to: Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer View less Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record June 2 2023 Citation Highlighted research articles. Cancer Discov 1 June 2023; 13 (6): 1275–1277. https://doi.org/10.1158/2159-8290.CD-13-6-ITI Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Follicular lymphomas (FL) are spawned by elusive cancer precursor cells (CPC) that evade current therapies and thereby contribute to disease relapse. Schroers-Martin, Soo, Brisou, Scherer, and colleagues used sensitive liquid biopsy techniques to define the somatic genetic lesions of these CPCs to interrogate serial prediagnostic blood, saliva, and tissue samples collected from two large screening studies from patients who ultimately developed FL. In so doing, key recurrent somatic mutations in FL CPCs were identified with lesions in CREBBP's KAT domain as specific founder mutations of premalignant B-cell precursors detectable years before FL diagnosis. See article, p. 1310. The human pancreas is notoriously difficult to study due to rapid postmortem degradation and lack of indication to obtain tissue in the absence of disease. Utilizing a brain-dead organ donation pipeline to obtain disease-free pancreata with no warm ischemia time, Carpenter, Elhossiny, Kadiyala, and colleagues identified pancreatic cancer precursor lesions, known as... You do not currently have access to this content.