AB0242 IMPACT OF DISEASE ACTIVITY ON SLEEP DISORDERS IN RHEUMATHOID ARTHRITIS: A CROSS SECTIONAL STUDY ABOUT 100 PATIENTS
Authors: M. Brahem, B. Jebali, S. Abdellatif, R. Sarraj, O. Jomaa, H. Hachfi, Y. Mohamed
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Rheumatoid arthritis (RA) is an inflammatory autoimmune disease, characterized by joint pain, joint swelling in period of active disease and poor sleep. <h3>Objectives</h3> The present study aims to evaluate the sleep disorders in RA patients and to determine their relationship with disease activity. <h3>Methods</h3> This is a cross sectional study including RA patients followed in the rheumatology department at TAHER SFAR university hospital in Mahdia. All patients were diagnosed with RA based on 2010ACR/EULAR criteria. For each patient, we evaluated the Epworth sleepiness scale (ESS) [0-24] and Pitsburg sleep score [0-21] with its 7components. <h3>Results</h3> We included 100 participants with a mean age of 53,2 ±11,2 years [21-76 years] in which most of them (89%) were female. The average duration of diseases was 11,1±8,9 years [1- 40 years]. The assessment of the RA activity showed a mean DAS28(ESR) and DAS28(CRP) of 3.88±1.19 [1-6.15] and 4.6 ±1.19 [1-6.15] respectively. Highly active RA (DAS 28 ≥ 5.1) was found in 34 patients. The mean Epworth score was 7,9±5,6 [0-24], 28 patients (28% of cases) had signs of daytime sleepiness (ESS ≥ 11 points). The mean Pittsburgh global score was 6.9± 5.1 [0-19]. 51 patients (51% of cases) had disturbed sleep (PSQI &gt;5.5 points). Over half of participants (65.7%) rated the quality of sleep as very good or fairly good. 47.5 % of them were scored 0 for sleep duration; however, 17,2 % were sleeping fewer than five hours a night. 26 participants had long sleep latency (&gt;1 hour). The average sleep efficiency score was 0.92 ±1.25 [0-3]; only 21 reported such complaints. The mean score for sleep disturbance was 1.19±0.86 [0-3] and for daytime dysfunction was 0.79 ± 1.05 [0-3]; however, half of them (55%) presented this complaint. 86,9% of patients have not used a sleeping medication. Statistical analysis showed that the Pittsburg score was associated with a severe activity stage(p=0.045). Furthermore, we did not found any relationship between ESS and the disease activity. <h3>Conclusion</h3> Sleep disorders are common among RA patients and were frequently associated with severe disease activity. <h3>References</h3> [1] Sleep and rheumatologic disorders VC Abad, PSA Sarinas, C Guilleminault - Sleep medicine reviews, 2008 – Elsevier [2] Relationship between sleep disorders, pain and quality of life in patients with rheumatoid arthritis M Purabdollah, S Lakdizaji, A Rahmani… - Journal of caring …, 2015 [3] Frequency of sleep disorders in patients with rheumatoid arthritis M Mustafa, Y Bawazir, L Merdad, S Wali… - Open Access …, 2019 [4] Sleep Disorders among Individuals with Rheumatoid Arthritis P Katz, S Pedro, K Michaud - Arthritis care &amp; research, 2022 [5] Sleep disorders associated with risk of rheumatoid arthritis WS Chung, CL Lin - Sleep and Breathing, 2018 - Springer [6] Do sleepy rheumatoid arthritis patients have a sleep disorder? JA Gjevre, RM Taylor-Gjevre, BV Nair… - Musculoskeletal …, 2012 <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.