AB0988 FREQUENCY OF OSTEOPENIC SYNDROME AND LOW-ENERGY FRACTURES IN POSTMENOPAUSAL WOMEN WITH OSTEOARTHRITIS OF THE KNEE JOINT
Authors: E. Usova, T. Raskina, O. Malyshenko, M. Letaeva, M. Koroleva, J. Averkieva
Journal: Annals of the Rheumatic Diseases (2022)

Background The impact of knee osteoarthritis on the risk of low-energy fractures remains an open question in recent times. Some cohort studies show that OА of the knee joint is associated with increased risk of fractures [1-3]. Other studies do not support this link [4-5]. Objectives to compare the incidence of osteopenic syndrome and low-energy fractures in postmenopausal women with osteoarthritis (OA) of the knee joint. Methods The study includes 98 women, of whom: 51 (median age 63.0 [59.3;69.8] years) are diagnosed with OA of the knee joint according to the ACR criteria (1991) and 47 without OA of the knee joint (median age 65.0[61.8;71.0] years). The bone mineral density (BMD) (g/cm2) and the T-criterion (standard deviation, CO) of the femur neck and lumbar spine (LI-LIV) were evaluated by the two-energy X-ray absorption (DXA) method (Lunar Prodigy Primo, USA). The DXA data of the femoral neck and the lumbar spine were interpreted using the following reference intervals: normal BMD - T-criterion -1 CO, osteopenia - T-criterion from -1 or less CO. Low-energy fractures were considered to have occurred with minimal trauma (falling from a height of own height to the same surface or an even smaller injury) and were found in the anamnesis. Results In the group of patients with OA of the knee joint, normal BMD was found to be statistically significantly more frequent than the control group (15.7% vs. 4.3%) p=0.033. It is shown that in women with OA of the knee joint, low-energy fractures were statistically less recorded than in the control group: in 29.4% and 51.0% of women respectively (p=0.002). The chances of having low-energy fractures in the group of patients with OA of the knee joint were statistically lower by a factor of 2.64 compared to the control group (OR = 0.378; 95%CI: 0.203 - 0.703). Conclusion The low frequency of low-energy fractures and the lower the chances of them in women with OA of the knee joint compared to the control group are probably associated with lower prevalence of the osteopenic syndrome among these patients. References [1]Smith TO, Higson E, Pearson M, Mansfield M. Is there an increased risk of falls and fractures in people with early diagnosed hip and knee osteoarthritis? Data from the Osteoarthritis Initiative. Int J Rheum Dis. 2018;21(6):1193-1201. doi:10.1111/1756-185X.12871 [2]Soh SE, Barker AL, Morello RT, Ackerman IN. Applying the International Classification of Functioning, Disability and Health framework to determine the predictors of falls and fractures in people with osteoarthritis or at high risk of developing osteoarthritis: data from the Osteoarthritis Initiative. BMC Musculoskelet Disord. 2020;21(1):138. Published 2020 Feb 29. doi:10.1186/s12891-020-3160-5 [3]Jacob L, Kostev K. Osteoarthritis and the incidence of fracture in the United Kingdom: a retrospective cohort study of 258,696 patients. Osteoarthritis Cartilage. 2021;29(2):215-221. doi:10.1016/j.joca.2020.12.006 [4]Vala CH, Kärrholm J, Kanis JA, et al. Risk for hip fracture before and after total knee replacement in Sweden. Osteoporos Int. 2020;31(5):887-895. doi:10.1007/s00198-019-05241-x [5]Barbour KE, Sagawa N, Boudreau RM, et al. Knee Osteoarthritis and the Risk of Medically Treated Injurious Falls Among Older Adults: A Community-Based US Cohort Study. Arthritis Care Res (Hoboken). 2019;71(7):865-874. doi:10.1002/acr.23725 Acknowledgements We thank Vyacheslav Fanaskov and Svetlana Skutina are radiologists of State Autonomous healthcare institution “Kuzbass clinical hospital for war veterans” for the possibility of holding the two-energy X-ray absorption. Disclosure of Interests None declared