tbuckley/cabot-search huggingface dataset:
43882 Pharmacokinetics, Safety, and Efficacy of Cedirogant (ABBV-157) in Patients With Moderate-to- Severe Plaque Psoriasis
Authors: Ronilda D'Cunha, Teresa Sligh, Laura K. Ferris, Ann Eldred, Shuai Hao, Wei Liu, Sasha Jazayeri, Howard Sofen, Roberto Carcereri, Mohamed-Eslam F. Mohamed
Journal: Journal of the American Academy of Dermatology (2023)
42915 Topical application of INV-10000001, a first-in-class HSP47 inhibitor, attenuates hypertrophic scar in porcine and rodent animal models
Authors: Jung Gyu Park, Joonghoon Park, Dong Chul Lim, Jongsoo Mok, Jeong Hwan Park, Seoah Park
Journal: Journal of the American Academy of Dermatology (2023)
40666 Long-term Safety of Apremilast From a Pooled Analysis of 15 Randomized, Placebo-Controlled Studies of Psoriasis, Psoriatic Arthritis, and Oral Ulcers Associated With Behçet’s Syndrome
Authors: Philip J. Mease, Gülen Hatemi, Maria Paris, Sue Cheng, Peter Maes, Wendy Zhang, Rebecca Shi, Andrea Flower, Linda Stein Gold
Journal: Journal of the American Academy of Dermatology (2023)
44265 Oral coenzyme Q10: the new authority in skin aging. Results of a randomized, double-blind, placebo-controlled trial in elderly women
Authors: Marcelle Nogueira, Mirian Sotto, José Antonio Sanches, Neusa Valente, Luanda Oliveira, Natalli Pereira, Luiz Fernado Silva, Maria Sato, Edileia Bagatin
Journal: Journal of the American Academy of Dermatology (2023)
40858 Mean neutrophil-to-lymphocyte ratio improves over time with guselkumab treatment vs. placebo in the VOYAGE 1 and VOYAGE 2 clinical trials
Authors: Brian Kirby, Niamh Kearney, Patricia Gorecki, Jozefien Buyze, Ya-Wen Yang, Joseph Merola
Journal: Journal of the American Academy of Dermatology (2023)
42450 Cutaneous Adverse Events In Patients Treated With Immune Checkpoint Inhibitors. A Prospective Study In A Spanish Tertiary Care Hospital
Authors: Gloria Juan Carpena, Natividad Martinez Banaclocha, Juan Carlos Palazón Cabanes, María Niveiro de Jaime, Isabel Betlloch Mas, Mar Blanes Martinez
Journal: Journal of the American Academy of Dermatology (2023)
42253 Baseline Demographics and Comorbidities in Patients With Atopic Dermatitis: an Update From the GLOBOSTAD Registry
Authors: Piergiacomo Calzavara-Pinton, Jarmila Celakovská, Hilde Lapeere, Gregor Holzer, Mona Al-Ahmad, Chia-Yu Chu, Jiangming Wu, Marius Ardeleanu, Kwinten Bosman
Journal: Journal of the American Academy of Dermatology (2023)
44007 Risankizumab Long-Term Safety in Patients With Psoriatic Disease: Integrated Interval Analyses From Psoriasis and Psoriatic Arthritis Clinical Trials
Authors: Kenneth Gordon, Andrew Blauvelt, Laura C. Coates, Blair Kaplan, Willem Koetse, Leonidas Drogaris, Ranjeeta Sinvhal, Kim A. Papp
Journal: Journal of the American Academy of Dermatology (2023)
41824 Palmoplantar psoriasis complete clearance is achieved rapidly and sustained with ixekizumab treatment in adult and pediatric patients with moderate-to-severe plaque psoriasis
Authors: Martin Alan Menter, April Armstrong, Leon Kircik, Robert Gniadecki, Alyssa Garrelts, Kyoungah See, Missy McKean-Matthews, Jerry Bagel
Journal: Journal of the American Academy of Dermatology (2023)
44321 Impact of the COVID19 pandemic on Non-Melanoma Skin Cancer in Puerto Rico
Authors: Diana V. Rodriguez-Rivera, Claudia Perez-Draper, Fabiola Pabon- Gonzalez, Idalis Cardona-Ortiz, Sheila Valentin-Nogueras, Luz Figueroa-Guzman
Journal: Journal of the American Academy of Dermatology (2023)
43272 Differentiation of Therapeutic Monoclonal Antibodies Targeting IL-23 for the Treatment of Psoriatic Disease
Authors: Kilian Eyerich, James G. Krueger, Kacey Sachen, Carrie Greving, Deepa Hammaker, Phuc Bao, Eilyn Lacy, Iain B. McInnes, Anne Fourie
Journal: Journal of the American Academy of Dermatology (2023)
42248 Primary Cutaneous and Systemic Anaplastic CD30+ Large Cell Lymphoma: 4 cases of exclusively cutaneous relapse after autologous transplant
Authors: Marta Bertolín-Colilla, Cristina Muniesa, Lluis Colomo, Blanca Sánchez, Fina Climent, Eva González-Barca, Octavio Servitje, Ramon M. Pujol, Fernando Gallardo
Journal: Journal of the American Academy of Dermatology (2023)
42307 Matching-adjusted indirect comparison of efficacy of ixekizumab versus secukinumab through 1 year in pediatric patients with severe plaque psoriasis
Authors: Vimal H. Prajapati, Lisa Swanson, Christian Jossart, Kyoungah See, Alyssa Garrelts, Gholamreza S. Ardekani, Yan-Cheng Chao, Perla Lansang
Journal: Journal of the American Academy of Dermatology (2023)
43757 Improvement in pigmentation changes by Fitzpatrick skin type in actinic keratosis patients treated with tirbanibulin ointment 1%: pooled data from two Phase III studies
Authors: Andrew Blauvelt, Edward Lain, Todd Schleisinger, Paul Tomondy, Raidah Salem, Laura Padullés, Francisco Hernández, Meritxell Falques
Journal: Journal of the American Academy of Dermatology (2023)
40881 Examining Demographics, Comorbidities, and Quality of Life of Patients with a Dual Diagnosis of Hidradenitis Suppurativa and Psoriasis in the All of Us Database
Authors: Kareem Elhage, Jared Liu, Joy Jin, Riley Spencer, Samuel Yeroushalmi, Marwa Hakimi, Mitchell Davis, Tina Bhutani, Wilson Liao
Journal: Journal of the American Academy of Dermatology (2023)
Magnetic Microrobots Fabricated by Photopolymerization and Assembly
Authors: Xiyue Liang, Yue Zhao, Dan Liu, Yan Deng, Tatsuo Arai, Masaru Kojima, Xiaoming Liu
Journal: Cyborg and Bionic Systems (2023)

Magnetic soft microrobots have great potential to access narrow spaces and conduct multiple tasks in the biomedical field. Until now, drug delivery, microsurgery, disease diagnosis, and dredging the blocked blood vessel have been realized by magnetic soft microrobots in vivo or in vitro. However, as the tasks become more and more complex, more functional units have been embedded in the body of the developed magnetic microrobots. These magnetic soft microrobots with complex designed geometries, mechanisms, and magnetic orientation are now greatly challenging the fabrication of the magnetic microrobots. In this paper, we propose a new method combining photopolymerization and assembly for the fabrication of magnetic soft microrobots. Utilizing the micro-hand assembly system, magnetic modules with different shapes and materials are firstly arrayed with precise position and orientation control. Then, the developed photopolymerization system is employed to fix and link these modules with soft materials. Based on the proposed fabrication method, 3 kinds of soft magnetic microrobots were fabricated, and the fundamental locomotion was presented. We believe that the presented fabrication strategy could help accelerate the clinical application of magnetic microrobots.
The State-of-the-Art and Perspectives of Laser Ablation for Tumor Treatment
Authors: Yingwei Fan, Liancheng Xu, Shuai Liu, Jinhua Li, Jialu Xia, Xingping Qin, Yafeng Li, Tianxin Gao, Xiaoying Tang
Journal: Cyborg and Bionic Systems (2023)

Tumors significantly impact individuals' physical well-being and quality of life. With the ongoing advancements in optical technology, information technology, robotic technology, etc., laser technology is being increasingly utilized in the field of tumor treatment, and laser ablation (LA) of tumors remains a prominent area of research interest. This paper presents an overview of the recent progress in tumor LA therapy, with a focus on the mechanisms and biological effects of LA, commonly used ablation lasers, image-guided LA, and robotic-assisted LA. Further insights and future prospects are discussed in relation to these aspects, and the paper proposed potential future directions for the development of tumor LA techniques.
A Respiratory Motion Prediction Method Based on LSTM-AE with Attention Mechanism for Spine Surgery
Authors: Zhe Han, Huanyu Tian, Xiaoguang Han, Jiayuan Wu, Weijun Zhang, Changsheng Li, Liang Qiu, Xingguang Duan, Wei Tian
Journal: Cyborg and Bionic Systems (2023)

Respiratory motion-induced vertebral movements can adversely impact intraoperative spine surgery, resulting in inaccurate positional information of the target region and unexpected damage during the operation. In this paper, we propose a novel deep learning architecture for respiratory motion prediction, which can adapt to different patients. The proposed method utilizes an LSTM-AE with attention mechanism network that can be trained using few-shot datasets during operation. To ensure real-time performance, a dimension reduction method based on the respiration-induced physical movement of spine vertebral bodies is introduced. The experiment collected data from prone-positioned patients under general anaesthesia to validate the prediction accuracy and time efficiency of the LSTM-AE-based motion prediction method. The experimental results demonstrate that the presented method (RMSE: 4.39%) outperforms other methods in terms of accuracy within a learning time of 2 min. The maximum predictive errors under the latency of 333 ms with respect to the
Analysis of Rowing Force of the Water Strider Middle Leg by Direct Measurement Using a Bio-Appropriating Probe and by Indirect Measurement Using Image Analysis
Authors: Kaoru Uesugi, Hiroyuki Mayama, Keisuke Morishima
Journal: Cyborg and Bionic Systems (2023)

Rowing force of the middle leg of a water strider is one of the important factors affecting water repellency and applications in biomimetics, biomechanics, and biology. However, many previous studies have been based on estimated leg rowing force and lack some credibility. Therefore, we tried to measure leg rowing force directly by a force transducer. In this article, we report the rowing force of water striders obtained by direct and indirect measurements. In the direct measurement, water striders were set onto a sensor system and the rowing force of a middle leg of the set water striders was directly measured using a bio-appropriating probe (BAP), a kind of hook. In the indirect measurement, water striders were not fixed and the rowing force of locomoting water striders was evaluated by image analysis using a high-speed camera. As a result, we determined the rowing force by the direct measurement to be 955 μN, while the rowing force by the indirect measurement was 493 μN. We considered that the indirect measurement might lack some credibility because half the propellant energy was lost in the indirect force measurement due to various other factors.
Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington’s disease
Authors: Daniel O’Reilly, Jillian Belgrad, Chantal Ferguson, Ashley Summers, Ellen Sapp, Cassandra McHugh, Ella Mathews, Adel Boudi, Julianna Buchwald, Socheata Ly, Dimas Moreno, Raymond Furgal, Eric Luu, Zachary Kennedy, Vignesh Hariharan, Kathryn Monopoli, X. William Yang, Jeffery Carroll, Marian DiFiglia, Neil Aronin, Anastasia Khvorova
Journal: Molecular Therapy (2023)

(Molecular Therapy 31, 1661–1674; June 2023) In the originally published version of this article, the data for MSH2, PMS1, and PMS2 in Figure 6 were unintentionally duplicated. After reviewing the original data, the authors found that the MSH2 data had been accidentally copied and pasted into the PMS1 and PMS2 data cells during data analysis. The corrected figure has been provided below. The authors state that the conclusions of Figure 6 and the manuscript have not changed with this correction. This article has been corrected online, and the authors apologize for any confusion this may have caused.Figure 6. MSH3 silencing does not alter expression of additional mismatch repair genes (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington’s diseaseO'Reilly et al.Molecular TherapyMay 11, 2023In BriefKhvorova and colleagues demonstrate that the delivery of a di-valent siRNA to the CNS silences MSH3 and blocks disease-associated somatic expansion of CAG repeats in two Huntington’s disease mouse models. Full-Text PDF Open Access
Publisher Correction: Solanum americanum genome-assisted discovery of immune receptors that detect potato late blight pathogen effectors
Authors: Xiao Lin, Yuxin Jia, Robert Heal, Maxim Prokchorchik, Maria Sindalovskaya, Andrea Olave-Achury, Moffat Makechemu, Sebastian Fairhead, Azka Noureen, Jung Heo, Kamil Witek, Matthew Smoker, Jodie Taylor, Ram-Krishna Shrestha, Yoonyoung Lee, Chunzhi Zhang, Soon Ju Park, Kee Hoon Sohn, Sanwen Huang, Jonathan D. G. Jones
Journal: Nature Genetics (2023)
News &amp; views: anti-amyloid antibodies and novel emerging approaches to Alzheimer’s disease in 2023
Authors: Sam Gandy
Journal: Molecular Neurodegeneration (2023)

Alzheimer's disease (AD) was described over a century ago as a disease of dementia with the presence of amyloid and tau pathologies [1], but the past year has seen the first clear evidence that effective disease-modifying anti-amyloid antibody (AAA) therapies are possible.Both aducanumab [2] (from Biogen) and lecanemab [3,4] (from an Eisai-Biogen collaboration) earned accelerated approval from the US Food and Drug Administration (FDA) while lecanemab also earned traditional approval as well.With FDA review of donanemab [5,6] (Lilly) expected to take place close on the heels of the first two AAA drugs, now is an apt time to consider how the drugs compare and contrast and how to talk with patients about them.Though aducanumab was the first AAA approved (in June 2021), controversy ensued rapidly thereafter owing to questionable efficacy [2], and, though some prescriptions continue, the drug appears unlikely to earn a competitive market share, leaving lecanemab (L) and donanemab (D) as the two drugs from which practitioners will choose in the near term.While both L and D are delivered through intravenous infusions and both clear fibrillar Aβ based on amyloid positron emission tomography (PET) scan evidence, their properties diverge from there.
Clinical Validity and Conceptual Interpretation of Low-Dose Computed Tomography Screening in Asian Female Never-Smokers Are as Efficacious in Detecting Lung Cancer as in Asian Male Ever-Smokers
Authors: Rama Jayaraj, Sameep Shetty, Srinidhi Ilankumaran, Yash Merchant
Journal: Journal of Thoracic Oncology (2023)
Pyroptosis and inflammasomes in cancer and inflammation
Authors: Jie‐Lin Wang, Sheng‐Ni Hua, Hai‐Juan Bao, Jing Yuan, Yang Zhao, Shuo Chen
Journal: MedComm (2023)

Abstract Nonprogrammed cell death (NPCD) and programmed cell death (PCD) are two types of cell death. Cell death is significantly linked to tumor development, medication resistance, cancer recurrence, and metastatic dissemination. Therefore, a comprehensive understanding of cell death is essential for the treatment of cancer. Pyroptosis is a kind of PCD distinct from autophagy and apoptosis in terms of the structure and function of cells. The defining features of pyroptosis include the release of an inflammatory cascade reaction and the expulsion of lysosomes, inflammatory mediators, and other cellular substances from within the cell. Additionally, it displays variations in osmotic pressure both within and outside the cell. Pyroptosis, as evidenced by a growing body of research, is critical for controlling the development of inflammatory diseases and cancer. In this paper, we reviewed the current level of knowledge on the mechanism of pyroptosis and inflammasomes and their connection to cancer and inflammatory diseases. This article presents a theoretical framework for investigating the potential of therapeutic targets in cancer and inflammatory diseases, overcoming medication resistance, establishing nanomedicines associated with pyroptosis, and developing risk prediction models in refractory cancer. Given the link between pyroptosis and the emergence of cancer and inflammatory diseases, pyroptosis‐targeted treatments may be a cutting‐edge treatment strategy.
Transcriptional profiling of dental sensory and proprioceptive trigeminal neurons using single-cell RNA sequencing
Authors: Pa Reum Lee, Jihoon Kim, Heather Lynn Rossi, Sena Chung, Seung Yub Han, Junhyong Kim, Seog Bae Oh
Journal: International Journal of Oral Science (2023)

Dental primary afferent (DPA) neurons and proprioceptive mesencephalic trigeminal nucleus (MTN) neurons, located in the trigeminal ganglion and the brainstem, respectively, are essential for controlling masticatory functions. Despite extensive transcriptomic studies on various somatosensory neurons, there is still a lack of knowledge about the molecular identities of these populations due to technical challenges in their circuit-validated isolation. Here, we employed high-depth single-cell RNA sequencing (scRNA-seq) in combination with retrograde tracing in mice to identify intrinsic transcriptional features of DPA and MTN neurons. Our transcriptome analysis revealed five major types of DPA neurons with cell type-specific gene enrichment, some of which exhibit unique mechano-nociceptive properties capable of transmitting nociception in response to innocuous mechanical stimuli in the teeth. Furthermore, we discovered cellular heterogeneity within MTN neurons that potentially contribute to their responsiveness to mechanical stretch in the masseter muscle spindles. Additionally, DPA and MTN neurons represented sensory compartments with distinct molecular profiles characterized by various ion channels, receptors, neuropeptides, and mechanoreceptors. Together, our study provides new biological insights regarding the highly specialized mechanosensory functions of DPA and MTN neurons in pain and proprioception.
A study of genetic heterogeneity in autism spectrum disorders based on plasma proteomic and metabolomic analysis: multiomics study of autism heterogeneity
Authors: Xiaoxiao Tang, Chengyun Feng, Yuxi Zhao, Huajie Zhang, Yan Gao, Xueshan Cao, Qi Hong, Jing Lin, Hongbin Zhuang, Yuying Feng, Hanghang Wang, Liming Shen
Journal: MedComm (2023)

Genetic heterogeneity poses a challenge to research and clinical translation of autism spectrum disorder (ASD). In this study, we conducted a plasma proteomic and metabolomic study of children with ASD with and without risk genes (de novo mutation) and controls to explore the impact of genetic heterogeneity on the search for biomarkers for ASD. In terms of the proteomic and metabolomic profiles, the groups of children with ASD carrying and those not carrying de novo mutation tended to cluster and overlap, and integrating them yielded differentially expressed proteins and differential metabolites that effectively distinguished ASD from controls. The mechanisms associated with them focus on several common and previously reported mechanisms. Proteomics results highlight the role of complement, inflammation and immunity, and cell adhesion. The main pathways of metabolic perturbations include amino acid, vitamin, glycerophospholipid, tryptophan, and glutamates metabolic pathways and solute carriers-related pathways. Integrating the two omics analyses revealed that L-glutamic acid and malate dehydrogenase may play key roles in the pathogenesis of ASD. These results suggest that children with ASD may have important underlying common mechanisms. They are not only potential therapeutic targets for ASD but also important contributors to the study of biomarkers for the disease.
Differential traits between microvesicles and exosomes in enterovirus infection
Authors: Yuxuan Fu, Sidong Xiong
Journal: MedComm (2023)

Extracellular vesicles (EVs), including exosomes and microvesicles (MVs), are released by most cell types into the extracellular space and represent the pathophysiological condition of their source cells. Recent studies demonstrate that EVs derived from infected cells and tumors contribute to disease pathogenesis. However, very few studies have rigorously characterized exosomes and microvesicles in infectious diseases. In this study, we focused on subpopulations of EVs during the human enterovirus infection and explored the distinct traits and functions of EVs. We construct an effective immunomagnetic method to isolate exosomes and MVs from enterovirus-infected cells excluding virion. The morphology and sizes of exosomes and MVs have no significant alteration after enterovirus infection. Meanwhile, our study observed that the enterovirus infection could induce exosome secretion but not MVs. In vivo study showed that there was differential biodistribution between exosomes and MVs. Using deep RNA sequencing, we found that the cargo information in MVs rather than in exosomes could accurately reflect pathological condition of original cells. Our study demonstrated that it should be considered to use MVs as clinical diagnostics during in enterovirus infection because their composition is reflective of pathological changes.
Preferences and willingness-to-pay for a blood pressure telemonitoring program using a discrete choice experiment
Authors: Ian Yi Han Ang, Yi Wang, Shilpa Tyagi, Gerald Choon Huat Koh, Alex R. Cook
Journal: npj Digital Medicine (2023)

This study aimed to elicit the preferences and willingness-to-pay for blood pressure (BP) telemonitoring programs. This study also investigated the different factors or participant characteristics that could influence preferences and choice behaviors. Participants with hypertension were identified from an online survey panel demographically representative of Singapore's general population. Participants completed a discrete choice experiment (DCE) with 12 choice sets, selecting their preferred BP monitoring program differing on five attributes: mode of consultation, BP machine type (with Bluetooth or not), BP machine price, monthly fee, and program duration. The base reference population (male, married, higher income, more formal education years, full-time worker, aged 55 to <65 years, and digital skills score of 36) preferred teleconsultation over in-person consultation, Bluetooth feature, lower machine price, lower monthly fee, and shorter program duration. A subgroup of participants can be considered teleconsultation-resistant, and three demographic factors were associated with lower preference for teleconsultation: female, fewer formal education years, and lower income. Considering the reference population and Bluetooth attribute, participants were willing to pay 66 SGD (~49 USD) additional for the machine to obtain the Bluetooth feature. Considering the reference population and teleconsultation attribute, participants were willing to pay 6.80 SGD (~5.10 USD) extra monthly fee for a program using teleconsultation. Here we report that amongst participants with hypertension, there is strong preference for the use of teleconsultation and a BP machine with Bluetooth feature in a BP monitoring program. However, a subgroup of participants are teleconsultation-resistant and would prefer in-person consultation.