tbuckley/cabot-search huggingface dataset:
Course: Tissue Culture in the Study of Cancer
Journal: JNCI Journal of the National Cancer Institute (1986)

Journal Article Course: Tissue Culture in the Study of Cancer Get access JNCI: Journal of the National Cancer Institute, Volume 76, Issue 1, January 1986, Page 165, https://doi.org/10.1093/jnci/76.1.165-d Published: 01 January 1986
LOADED DICE
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heparin in the prevention of infusion phlebitis. A double-blind controlled study
Authors: H. W. Daniell
Journal: JAMA (1973)

In a double-blind controlled study of 151 patients admitted to a small coronary care unit, the addition of 1,000 units of beef-lung heparin to each liter of fluid given intravenously was found to reduce the frequency of thrombophlebitis at infusion sites. In 34 patients, 5% dextrose in water containing heparin was infused for a total of 2,243 hours with local inflammation requiring a change in catheter location on three occasions. In 30 patients receiving 5% dextrose in water without heparin, infused for a total of 2,659 hours, 20 changes in catheter location were required. Similar but less striking improvement was associated with heparin administration via catheters receiving 5% dextrose in water plus other medications. Among patients receiving conventional therapeutic doses of heparin by a continuous intravenous drip, infusion phlebitis was rarely present clinically, and polyethylene-catheter viability was greatly prolonged.
Acute Psychosis
Authors: Gerald Adler
Journal: New England Journal of Medicine (1974)

AN acute psychotic episode can be a frightening experience for the patient and his family as well as for the physician. The physician is faced with the responsibility for the careful assessment and sometimes the treatment of a patient who may be seriously suicidal, homicidal or otherwise out of control. Thorough diagnostic assessment, which is crucial in determining the nature of the acute psychotic episode, involves identifying precipitants and the underlying vulnerabilities, arriving at a formulation, and then devising a treatment plan based on the understanding derived from these complex factors. The non-psychiatric physician is often in an excellent position . . .
Nitroglycerin for Angina Pectoris
Authors: Herbert W. Copelan
Journal: JAMA (1978)

<h3>To the Editor.—</h3> As a physician responsible for the long-term care of patients with coronary disease, I welcomed the recent comments of Oglesby Paul, MD, on the medical management of angina pectoris (238:1847, 1977). I agreed particularly with his skepticism about the value of long-acting nitrates. I would disagree, however, with two of the statements about nitroglycerin. Because nitroglycerin may lose potency, Dr Paul recommends that a new supply of pills be obtained every six months. Nitroglycerin tablets lose potency by volatilization, which varies widely depending on many factors.<sup>1,2</sup>Discarding pills after six months is wasteful when the medication retains its strength. More important, replacing nitroglycerin after six months does not ensure potency. Tablets may weaken within only one or two months and sometimes may lack strength when first purchased. Dr Paul also mentions that nitroglycerin headache is a useful indication that the drug is active. Headache, however, does
High cholestanol and low campesterol-to-sitosterol ratio in serum of patients with primary biliary cirrhosis before liver transplantation
Authors: K Nikkilä
Journal: Hepatology (1991)

Serum levels of cholesterol precursors (squalene, Δ8-cholestenol, desmosterol and lathosterol), plant sterols (campesterol and sitosterol), cholestanol and cholestanol/noncholesterol sterol ratios were related to liver damage and liver transplantation indications in healthy controls (n = 26) and in 31 patients with primary biliary cirrhosis divided into group I (S-bilirubin < 21 μmol/L; n = 14), group II (S-bilirubin 21 to 108 μmol/L; n = 7) and group III (elected for liver transplantation; S-bilirubin 109 to 520 μmol/L; n = 10). The mean sérum respective lathosterol levels in controls and in group I were three and two times higher than those in groups II and III, respectively. The plant sterol contents were higher in group II than in groups I and III and the campesterol/sitosterol ratios were lowest in group III. The serum cholestanol levels were high even in group I (i.e., in patients without icterus) and increased progressively to group III, up to 6 and 13 times those in group I and the control group, respectively. The cholestanol/noncholesterol sterol ratios increased progressively from the controls to groups I, II and III. The serum cholestanol levels were positively related to serum bilirubin levels in all primary biliary cirrhosis patients (n = 31, r = 0.906) and to the plant sterol levels in the control group and group I, but significantly negatively in group III. The cholestanol vs. precursor sterol correlations were negative in most cases. In conclusion, our findings suggest that determination of serum cholestanol and lathosterol levels and cholestanol/plant sterol, campesterol/sitosterol and campesterol/lathosterol ratios might aid staging of liver damage in primary biliary cirrhosis. The high serum cholestanol level associated with the low campesterol/sitosterol ratio could be a significant indicator of end-stage primary biliary cirrhosis and, finally, of the need for liver transplantation. (HEPATOLOGY 1991;13:663–669.)
Hematology
Authors: William Dameshek
Journal: New England Journal of Medicine (1946)

The SpleenIN its normal state, the spleen is a relatively small organ weighing 50 to 100 gm. and containing a variable amount of blood. Its function as a reservoir was thoroughly studied twenty-one years ago by Barcroft et al.1 Removal of the normal spleen is followed by a number of interesting blood changes2—a tendency toward an increase in the red-cell count, the development of thin red cells (target cells) with increased hypotonic resistance, the development of Howell—Jolly bodies (nuclear remains) in the red cells and increases in the white-cell and platelet counts. These changes indicate a definite relation . . .
Author! Author!
Authors: Tom Smith
Journal: JAMA (1990)

My patient was a 70-year-old man with prostate cancer metastatic to bone. He hurt all over, especially in the pelvis and left femur, and x-ray films confirmed multiple small lytic and blastic lesions. He had been referred by a very good internist in my rural state after hormonal therapy had lost its initial effectiveness. I knew he would get good care at my university hospital but would be isolated from his family by time, distance, and money. The prospect of his driving 100 miles over often bumpy roads was not attractive. His family asked me if there was a clinic closer to home. Our clinical nurse specialist located a radiation therapy facility miraculously only a few miles from the patient's home. While I did not know the reputation of the treatment center or its practitioners, it seemed a far better choice for my patient than lengthy trips to my own
Abstract 3153: Prostatic acid phosphatase (PAP) predictive effect for prostate cancer in a population-based study: The renewal of PAP
Authors: Fubo Wang, Huan Xu, Yinghao Sun
Journal: Cancer Research (2019)

Abstract Objective: Use prostatic specific acid phosphatase (PAP) to characterize the disease progression and median survivals of patients with prostate cancer (PCa) based on the analysis in a population-based study from Surveillance, Epidemiology, and End Results (SEER) database. Materials and Methods: PCa patients with completed PAP results were selected from the SEER database of the National Cancer Institute. Mann-Whitney Sum test was utilized to compare the statistical significance for measurement data and ranked data, which were stratified by age, race, TNM Classification of Malignant Tumors (TNM), pathological grades, number of tumors, PAP and survival duration. Logistic analysis was performed to identify predictors of the presence of invasion and metastases. Cox regression was utilized to analyze the factors associated with all-cause mortality and prostate-cancer specific mortality. Moreover, survival curve was also present. Results: In total, there are 5184 PAP+ patients and 3161 PAP- patients involved in this study. The Mann-Whitney Sum test showed that slightly greater tumor size(p=0.03), elevated lymphatic (p=0.005) and distant (p&amp;lt;0.001) metastases rate, higher pathologic grade(p&amp;lt;0.001), localized tumor number (p&amp;lt;0.001), shortened survival months (p&amp;lt;0.001) were observed in the PAP+ group compared with the PAP- group. In the Multivariable Logistic Regression, invasion and metastases Hazard Ratio (HR) were elevated significantly (p&amp;lt;0.001) in the PAP+ individuals. In the survival analysis, PAP- patients experience the prolonged median survival. In the post-surgical patients, the survival months were still longer in PAP+ patients compared with the negative ones (p&amp;lt;0.001), though surgery prolonged the survival months of both groups. Survival months stratified by localized, invasion and metastases situations were analyzed. In the three stratified sub-groups, survival duration is significantly decreased in the PAP+ individuals in the localized PCa group (P&amp;lt;0.001**) and the metastases group (P=0.013). Conclusions: The findings of this study provide population-based estimates of the PCa progress and prognosis for patients with different PAP results, which may suggest a renewed period for the PAP. Citation Format: Fubo Wang, Huan Xu, Yinghao Sun. Prostatic acid phosphatase (PAP) predictive effect for prostate cancer in a population-based study: The renewal of PAP [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3153.
<i>Announcement</i>: World Pneumonia Day — November 12, 2017
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

World Pneumonia Day, observed on November 12 each year, aims to highlight the huge toll pneumonia takes on children and adults worldwide.In 2015, an estimated 2.7 million persons died from respiratory infections, including 700,000-920,000 children aged <5 years (1,2).Streptococcus pneumoniae and Haemophilus influenzae type b bacteria cause most of these deaths; however, viruses, including influenza and respiratory syncytial virus, also have a considerable impact (1).Multiple vaccines are available to help prevent pneumonia, including Haemophilus influenzae type b, influenza, measles, pertussis, pneumococcal, and varicella vaccines.Expanding the use of the pneumococcal conjugate vaccine in childhood immunization programs around the world has reduced disease incidence in recent years, particularly among children aged <5 years (3).Despite progress globally in reducing the incidence of pneumonia, recent U.S. outbreaks serve as a reminder of the importance of maintaining high vaccination coverage to prevent pneumonia.For example, as of August 25, 2017, more than a quarter (28%) of 79 measles patients in a Minnesota community with low measles-mumps-rubella vaccination coverage required hospitalization, primarily for treatment of dehydration or pneumonia (4).In addition to vaccination, other strategies have been proven to help prevent pneumonia.Adherence to antibiotic use guidelines reduces the development of antibiotic resistance among pneumonia-causing organisms.In addition, access to tobacco cessation programs (5), decreased exposure to secondhand smoke (5) and reduction in indoor air pollution from biomass smoke in developing countries (6) are important pneumonia prevention strategies that can save lives.Continued efforts to improve access to appropriate treatment for those who get pneumonia are also needed.Information about World Pneumonia Day, including the 2017 Pneumonia and Diarrhea Progress Report, is available at http://stoppneumonia.org/.
'Brain Death'
Authors: John J. Oro
Journal: JAMA (1989)

<h3>To the Editor.—</h3> In their editorial, Dr Wikler and Mr Weisbard<sup>1</sup>suggest that the reason for the confusion regarding the determination of "brain death" is due to conceptual confusion; they propose a change in the definition of brain death that would allow it to be declared when higher cortical functions are lost regardless of brain-stem function. Such a redefinition undoubtedly would increase the number of organs available for transplantation. While this is a worthwhile goal, the physician making the determination should keep in mind that the fundamental reason for the concept of brain death is patient centered and based on an understanding of the nature of man. As stated by Veith et al,<sup>2</sup>"In the circumstance of brain death, neither a human being nor person any longer exists... it is an affront to the individual person or that person's memory to treat a human being who has irreversibly
Excitatory Amino Acid Neurotransmission: NMDA Receptors And Hebb-Type Synaptic Plasticity
Authors: C. Cotman
Journal: Annual Review of Neuroscience (1988)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Homoeopathic medicine.
Authors: R S Walker
Journal: BMJ (1979)

graft tissue, skin, to an abnormal culture atmosphere (45 ,' CO2 in air) for various periods (7-48 h).Normally-cultured skin grafts caused no lymphoid malignancy.Immunogenicity of exposed grafts as a result of modification of cell-surface proteins and production of "altered self" structures may be a factor in the subsequent appearance of lymphoma in these autologous hosts.In the animal models described above, malignant lymphoma develops as a late sequela of transplantations in the absence of exogenous immunosuppressants; chronic antigenic stimulation appears to be a possible common factor.Significantly, only lymphoid neoplasms developed despite the grafting of four different tissues-lymph node, mammary gland, skin, and bone marrow.Bone marrow is the only tissue that did not induce lymphoma in its recipients even following exposure to an unphysiological environment.This raises the question whether the T lymphocytes in the graft tissues are involved in the malignant processes in these animal models.
Enhanced Myocardial Angiogenesis by Gene Transfer With Transplanted Cells
Authors: Terrence M. Yau, Karen Fung, Richard D. Weisel, Takeshiro Fujii, Donald A.G. Mickle, Ren-Ke Li
Journal: Circulation (2001)

Background The combination of myocardial cell transplantation and angiogenic gene transfer may improve postinfarction left ventricular (LV) perfusion. We evaluated the angiogenic effect of heart cells transfected with vascular endothelial growth factor (VEGF) and transplanted into a myocardial scar. Methods and Results Donor rat heart cells were transfected with plasmids encoding VEGF 165 and green fluorescence protein. Syngeneic adult rats underwent LV cryoinjury to create a transmural scar. Three weeks later, 4×10 6 transfected heart cells (n=14), untransfected heart cells (n=13), or culture medium (n=16) were transplanted into the center of the scar. After 5 weeks, LV function, quantitative histology, and regional blood flow were evaluated. Plates of heart cells transfected with VEGF 165 produced 6.1 times more intracellular VEGF than nontransfected cells. Capillary density (mean±SEM) per high-power field in the center of the myocardial scar was 1.1±0.02 in control rats, 3.9±0.11 in untransfected rats, and 6.3±0.11 in transfected rats ( P =0.0002). Capillary density in the border zone around the scar was 1.9±0.03 in control rats, 6.4±0.10 in untransfected rats, and 8.7±0.16 in transfected rats ( P =0.004). Regional blood flow within the scar was 8.8±0.8% of normalized flow in control hearts, 10.4±0.7% in hearts transplanted with untransfected cells, but 17.6±1.2% in hearts transplanted with transfected cells ( P =0.03 versus control, P =0.07 versus nontransfected). There was no difference in LV function attributable to transplantation with transfected cells at the time point studied. Conclusions Transplantation of heart cells transfected with VEGF induced greater angiogenesis than transplantation of unmodified cells. Combined gene transfer and cell transplantation strategies may improve postinfarction LV perfusion and function.
AMA Auxiliary
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lyme arthritis: not confined to the East Coast
Authors: Z. Danilevicius
Journal: JAMA (1979)

Some medical discoveries happen to be initiated by laymen. In November 1975 a mother from the town of Old Lyme, Conn, informed the state health department of an unusually high incidence of an illness diagnosed as juvenile rheumatoid arthritis in her small community. Another mother in the same town soon reported a cluster of similar illness in her family; her husband, two of their children, and several neighbors all had the same type of arthritis. Soon a team of physicians from the Yale University School of Medicine began investigating the unusual outbreak of the supposed juvenile rheumatoid arthritis in Connecticut. In three contiguous Connecticut communities, Steere et al<sup>1</sup>studied the cases of 51 residents (39 children and 12 adults) who had an illness characterized by a symmetric swelling and pain in a few large joints, some of them with an edematous papule that developed into an expanding red annular
The anatomy of an arrhythmia
Authors: R. F. Gilmour
Journal: Journal of Clinical Investigation (2004)

Computer simulations are potentially effective approaches to unraveling the causes of lethal heart rhythm disorders. In this issue of the JCI, Xie et al. have embedded a well-characterized dynamic mechanism for arrhythmia development in an anatomically realistic computer model of the heart. Their demonstration that this simple mechanism governs the behavior of the complex model may provide a new target for strategies to prevent sudden death.
ANNOUNCEMENTS IN THE PRESS.
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tumor Virus Epidemiology Repository Specimens Available
Journal: JNCI Journal of the National Cancer Institute (1984)

Journal Article Tumor Virus Epidemiology Repository Specimens Available Get access JNCI: Journal of the National Cancer Institute, Volume 73, Issue 1, July 1984, Page 301, https://doi.org/10.1093/jnci/73.1.301-e Published: 01 July 1984
SWEDEN
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal