AB1226 CLINICAL SIGNIFICANCE OF A PATIENT COMPLIANCE IN PREVENTION OF SECONDARY FRACTURES
Authors: E. Simakova, I. Zborovskaya, В. Zavodovsky, L. Seewordova, J. Polyakova, E. Papichev, Y. Akhverdyan
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Objectives</h3> to evaluate the effect of compliance in patients with osteoporosis on the incidence of new fragility fractures. <h3>Methods</h3> The study was performed in two stages. At the 1st stage, a retrospective analysis of outpatient records for the period from December 2019 to December 2021 was completed in the Volgograd Center of Osteoporosis. During Phase II of the study, in December 2022, researchers conducted a telephone survey to identify new fractures. <h3>Results</h3> The analysis included outpatient records of 2236 patients aged 40 to 92 years with DEXA scan. (1897 women and 339 men). 715 patients out of 2236 (control group or 31.98% of all included in the study) were found to have an abnormal DEXA, but lost follow up, among 715 patients from the control group, 509 (71%) patients were diagnosed with osteoporosis, 115 patients had a history of fragility fractures [1,2]. But these patients refused to attend the school for patients with osteoporosis and offered treatment. 158 patients in this group (26.51%) reported new low-traumatic fractures on a telephone survey. The remaining 1521 patients out of 2236 (68.02% of all included in the study) were followed up and treated in our Osteoporosis Center. Of these, 1262 patients (82.97%) were diagnosed with osteoporosis and treated with anti-resorptive therapy [2]. 784 out of 1262 patients (62.12%) were compliant with physician's recommendation, these patients constituted the II group of the study (highly compliant patients). Among these patients, only 11 new low-traumatic fractures (1.4%) were registered. Group III of the study (low compliance patients) consisted of 478 patients (37.88%) with a low physician's compliance.[3]. In this group, 42 new fragility fractures (8.79%) were identified. <h3>Conclusion</h3> 26.51% fragility fractures were registered in patients who refused monitoring and treatment. In the group of low compliance patients, 8.79% of new fractures were detected. While in the group of highly compliant patients, only 1.4% of new fractures were registered. <h3>References</h3> [1]Akhverdyan Yu., Zavodovsky B., Polyakova Yu., Seevordova L., et al. Clinical significance of serum irisin concentration as a marker of osteoporotic fracture// World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases. Abstracts Book. 2020. С. 248. [2]Gladkova E., Lesnyak O., Ershova O., Poljakova J., Ahverdjan J., Sivordova L., et al. Application of different approaches to detection of patients with a high risk of fractures in the russian population// World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases. Abstracts Book. 2021. С. 425. [3]Polyakova Yu., Sivordova L., Akhverdyan Yu., et al. Tapentadol in an of complex pain syndrome in osteoporotic vertebral fractures// World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases. Abstracts Book. 2020. С. 215. <h3>Acknowledgements</h3> <b>Di</b>sclosure of Interests: None Declared.