tbuckley/cabot-search huggingface dataset:
Awards, Appointments, Announcements
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Awards, Appointments, Announcements Get access JNCI: Journal of the National Cancer Institute, Volume 81, Issue 14, 19 July 1989, Pages 1059–1060, https://doi.org/10.1093/jnci/81.14.1059 Published: 19 July 1989
Effects of Riboflavin Deficiency on Metabolism of Nitrosamines by Rat Liver Microsomes&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Tianyuan Wang, Kenneth W. Miller, Yityoong Y. Tu, Chung S. Yang
 6
Journal: JNCI Journal of the National Cancer Institute (1985)

The effects of riboflavin deficiency on the metabolism of N-nitrosodimethylamine [(DMN) CAS: 62-75-9] and other nitrosamines were examined in rats. After weanling rats were put on a riboflavin-deficient diet, the development of the deficiency was monitored by the growth rate and the erythrocyte glutathione reductase activation coefficient. In the riboflavin-deficient rats, the liver microsomal NADPH-cytochrome c reductase activity was lower but the cytochrome P450 content was higher than that of the control. The metabolism of DMN was dependent on the severity of the deficiency. During mild deficiency, which was observed mainly with Sprague-Dawley rats, the microsomal DMN demethylase (DMNd) activity was elevated 30–80%, but the metabolism of N-nitrosomethylbenzylamine (CAS: 937-40-6) and three other nitrosamines was slightly decreased. Dietary restriction in the pair-fed group also caused an elevation of DMNd activity above that of the ad libitum control group due to a partial fasting effect. During severe deficiency, which was observed mainly with Wistar rats, however, the metabolism of DMN, as well as the oxidation of benzo[a]pyrene, was decreased. Preincubation with flavin adenine dinucleotide and flavin mononucleotide enhanced the DMNd activity of the microsomes from riboflavin-deficient rats but not that from control rats. The results suggest that, depending on the alterations of the monooxygenase enzyme system during the development of the deficiency, riboflavin deficiencies may have different effects on the metabolism of DMN and some other carcinogens.
Treatment of Tardive Dyskinesia and Mania with RBC Lithium Determinations
Authors: Larry Ereshefsky, Terry N. Rubin, Stephen Friedman
Journal: American Journal of Psychiatry (1979)

The authors report the usefulness of RBC lithium determinations in managing the treatment of tardive dyskinesia. They present a case report in which manic manifestations and tardive dyskinesia symptoms paralleled the rise and fall of RBC lithium and plasma lithium levels were constant during the period of symptom improvement. They conclude that RBC lithium levels appeared to reflect toxicity, control of mania, and symptom suppression of tardive dyskinesia better than plasma lithium levels alone.
Phagocytosis: Macrophage-Lymphocyte Interactions
Authors: Israel Siegel
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New twist in possible relationship between vasectomy, atherosclerosis
Authors: William A. Check
Journal: JAMA (1981)

During the last few years, research in primates showing that vasectomy can aggravate the development of atherosclerosis has caused considerable anxiety among men who have had or are contemplating having vasectomies. Results of the most recent primate research indicate that the extent of atherosclerosis in vasectomized vs control (sham-operated) monkeys may be linked to the animals' serum cholesterol levels. Speaking at the meeting of the American Association of Pathologists in Atlanta, Thomas B. Clarkson, DVM, of the Arteriosclerosis Research Center, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC, said that he saw the greatest difference in the extent of arterial plaque between vasectomized and control monkeys when the one third of animals with the most extensive lesions in each treatment group were compared. Another aspect of the project was carried out by Nancy Alexander, PhD, of the Oregon Regional Primate Research Center, Beaverton, who found that antisperm antibodies
The Yield From Pelvic Endoscopy
Authors: John W. Harris
Journal: JAMA (1971)

Richly supplied with nerves and uniquely subject to hormonal and gestational changes, the female pelvic structures often are associated with pain and tumor formation. Examination under anesthesia, culdocentesis, and colpotomy have been the classical methods of diagnosis. More recently, endoscopic procedures have improved the accuracy of evaluating the uterus, fallopian tubes, and ovaries. This study compares 45 patients who underwent culdoscopy and 40 who had laparoscopy performed. Seventy-six of these had pelvic pain or tumor; the remainder, a variety of more obscure symptoms referable to the pelvis. The indications for use of the two procedures confirm the panoramic view of the pelvis obtainable with the laparoscope. In cases requiring a thorough evaluation of all pelvic structures, the conclusion is reached that laparoscopy is the more useful technique.
In the hot seat: thermography for breast cancer diagnosis
Authors: Marsha F. Goldsmith
Journal: JAMA (1984)

Thermography—a direct method of measuring skin temperature either as discrete values or in the form of a visual image—is ineffective for detecting clinically occult breast cancer and should not be used as an indicator for biopsy. That's the opinion of the American College of Radiology (ACR), as expressed in a strongly worded policy statement issued at the recent Chicago meeting of the Radiological Society of North America (RSNA). Spokesman Gerald D. Dodd, Jr, MD, chair of radiology at M. D. Anderson Hospital and Tumor Institute, Houston, and a former president of the American Thermographic Society (1976 to 1977), said that although thermograms are virtually useless in diagnosing breast cancer in asymptomatic women, many physicians routinely use them for this purpose. A number of women who believe that even reduceddose mammography is unsafe readily accept thermography, which is noninvasive and does not employ ionizing radiation. However, the reality, says the ACR,
Sporadic and epidemic community legionellosis: two faces of the same illness
Authors: N. Sopena, L. Force, M. L. Pedro-Botet, P. Barrufet, G. Sauca, M. García-Núñez, G. Tolchinsky, J. A. Capdevila, M. Sabrià
Journal: European Respiratory Journal (2007)

The present study compares the risk factors, presentation and outcome of community-acquired Legionella pneumophila pneumonia in 138 sporadic-case patients (1994–2004) and 113 outbreak-case patients (2002) treated in two hospitals in Catalonia (Spain) since urinary antigen assays were adopted. Univariate and multivariate analysis were performed to compare epidemiological and clinical features, blood chemistry values, radiological findings and outcome of sporadic and epidemic legionnaires' disease. Univariate analysis showed that male sex, chronic lung disease, HIV infection and immunosuppressive therapy prevailed in sporadic cases. Presentation with respiratory symptoms, confusion and blood chemistry alterations, such as hyponatraemia, aspartate aminotransferase and blood urea nitrogen elevation, and partial pressure of oxygen P O 2 &lt;7.98 KPa (60 mmHg) were also more frequent in sporadic cases, while headache prevailed in outbreak cases. Sporadic cases had a greater delay in treatment, were more severe and had a worse outcome than epidemic cases. Multivariate analysis showed significant differences in sex, chronic lung disease, HIV infection and headache. The clinical and outcome differences between the two groups may be explained by the detection of milder forms of legionnaires' disease, the earlier treatment and the lower severity of underlying disease in the outbreak cases.
OP0290 WHICH INFLAMED TISSUES EXPLAIN A POSITIVE SQUEEZE TEST OF THE METATARSOPHALANGEAL JOINTS? A LARGE IMAGING STUDY TO INCREASE UNDERSTANDING OF A COMMONLY PERFORMED DIAGNOSTIC PROCEDURE
Authors: B. van Dijk, Y. Dakkak, D. Krijbolder, J. van Zeben, I. Tchetverikov, M. Reijnierse, A. van der Helm-van Mil
Journal: Annals of the Rheumatic Diseases (2022)

Background The squeeze test of metatarsophalangeal (MTP-)joints is frequently used, because it is easy and cheap, and is traditionally perceived as a test for synovitis. Besides classic intra-articular synovitis also tenosynovitis and intermetatarsal bursitis (IMB) represent synovial inflammation, albeit juxta-articularly located. Both are frequently present in RA and occasionally in other arthritides. However, the contribution of IMB to MTP squeeze test positivity is unknown and the contribution of tenosynovitis has only been partially studied. Objectives To assess whether tenosynovitis and IMB contribute to a positive MTP squeeze test. Methods 192 early arthritis patients and 693 CSA-patients underwent the MTP squeeze test and forefoot MRI at first presentation. MRI measurements in age-matched healthy controls were used to define positivity for synovitis, tenosynovitis and IMB. Logistic regression was used; multivariable models adjusted for sex and simultaneous presence of inflammation features. Results In early arthritis patients synovitis (OR 4.8 (95%CI 2.5–9.5)), tenosynovitis (2.4 (1.2–4.7)) and IMB (1.7 (1.2–2.6)) associated with positivity of the MTP squeeze test. Synovitis (3.2 (1.4–7.2)) and IMB (3.9 (1.7–8.8)) remained associated in multivariable analyses. Of patients with a positive MTP squeeze test, 79% had synovitis or IMB: 12% synovitis, 15% IMB and 52% both synovitis and IMB. In CSA-patients, subclinical synovitis (3.0 (2.0–4.7)), tenosynovitis (2.7 (1.6–4.6)) and IMB (1.7 (1.2–2.6)) associated with MTP squeeze test positivity. In multivariable analyses, synovitis remained independently associated (2.5 (1.5-4.1)) whilst tenosynovitis (1.5 (0.8-2.9)) and IMB did not (1.2 (0.8-1.8)). Of patients with a positive MTP squeeze test, 39% had synovitis or IMB: 10% synovitis, 15% IMB and 13% both synovitis and IMB. Conclusion Besides synovitis, also IMB contributes to pain upon compression in early arthritis, presumably due to its location between MTP joints. This is the first evidence showing that a positive MTP squeeze test positivity is not only explained by intra- but also juxta-articular inflammation. Disclosure of Interests None declared
Physical Chemistry for Students of Biology and Medicine.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Was Neurasthenia a 'Legitimate Morbid Entity'?
Authors: Robert L. Martensen
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diurnal Variation in Susceptibility of Mouse Skin to the Tumorigenic Action of Methylcholanthrene&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Iversen, Ulla, Iversen, Olav Hilmar, Hennings, Henry, Bjerknes, Rolf
Journal: JNCI Journal of the National Cancer Institute (1970)

Journal Article Diurnal Variation in Susceptibility of Mouse Skin to the Tumorigenic Action of Methylcholanthrene Get access Ulla Iversen, Ulla Iversen Institute for General and Experimental Pathology, University of Oslo, Rikshospitalet, Oslo 1, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar Olav Hilmar Iversen, Olav Hilmar Iversen Institute for General and Experimental Pathology, University of Oslo, Rikshospitalet, Oslo 1, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar Henry Hennings, Henry Hennings Institute for General and Experimental Pathology, University of Oslo, Rikshospitalet, Oslo 1, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar Rolf Bjerknes Rolf Bjerknes Institute for General and Experimental Pathology, University of Oslo, Rikshospitalet, Oslo 1, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 45, Issue 2, August 1970, Pages 269–276, https://doi.org/10.1093/jnci/45.2.269 Published: 01 August 1970 Article history Received: 29 January 1970 Accepted: 04 May 1970 Published: 01 August 1970
Acute Renal Failure and Rhabdomyolysis After Ingestion of Phenylpropanolamine-Containing Diet Pills
Authors: Robert D. Swenson
Journal: JAMA (1982)

PHENYLPROPANOLAMINE hydrochloride is a sympathomimetic agent found in more than 70 over-the-counter appetite suppressants and nasal decongestants. Acute amphetaminelike CNS stimulation and hypertension, reviewed elsewhere,<sup>1</sup>and acute renal failure<sup>2</sup>have been associated with phenylpropanolamine use. We describe two patients with acute renal failure and rhabdomyolysis following the ingestion of phenylpropanolamine, suggesting that muscle injury may contribute to the renal insult. <h3>Report of Cases</h3><h3>Case 1.—</h3> The patient is the subject of an earlier correspondence.<sup>3</sup>Acute renal failure developed in a 28-year-old woman after three weeks of ingesting an appetite suppressant containing phenylpropanolamine (Full-stop). She manifested symptoms, signs, and laboratory evidence of rhabdomyolysis and recovered with conservative treatment of her renal failure. She also received ampicillin trihydrate for<i>Escherichia coli</i>bacteriuria. Percutaneous renal biopsy disclosed acute interstitial nephritis, which could have been due to drug ingestion or pyelonephritis. Although it is possible that the renal failure was the
Postpartum Candida Endophthalmitis
Authors: Herbert L. Cantrill
Journal: JAMA (1980)

Two patients experienced endogenous<i>Candida</i>endophthalmitis after childbirth. One case was successfully treated with vitrectomy and intravitreal injection of amphotericin B. Although rare,<i>Candida</i>endophthalmitis must be included in the differential diagnosis in the postpartum patient with visual symptoms. (<i>JAMA</i>243:1163-1165, 1980)
Adenylate cyclase activity in microdissected rat liver tissue: Periportal to pericentral activity gradient
Authors: Christian Cortinovis, Fritz Klimek, Enrique Nogueira
Journal: Hepatology (1993)

Adenylate cyclase activity was measured in microdissected samples from lyophilized cryostat sections of rat liver by means of an improved assay. Livers were obtained from adult Sprague-Dawley rats fasted for 22 hr. Adenylate cyclase activities, basal and those elicited by various agents, were determined in dissected samples from periportal and pericentral regions of the classic liver lobule. In all samples, enzyme activity was strongly stimulated by glucagon, cholera toxin, guanosine-5′-O-(3-thiotriphosphate), sodium fluoride and forskolin. The β-adrenergic agonist isoproterenol produced very weak, if any, enzyme stimulation. Angiotensin II did not inhibit the activity elicited by lithium chloride and GTP at high concentrations, and pertussis toxin did not enhance the GTP-stimulated activity. We observed a periportal-to-pericentral gradient for basal and agent-stimulated activities. (Hepatology 1993;18:160-164).
Elbow Dislocation With Radial Head Fracture
Authors: Otto E. Aufranc
Journal: JAMA (1966)

Dr. Joseph L. Shaw: A 48-year-old woman fell on the sidewalk while attempting to avoid being struck by a bicycle. She thinks that she landed directly on the elbow rather than on the hand. She was seen in the emergency ward at the Massaschusetts General Hospital less than an hour following her injury. Results of a physical examination were normal except for the right elbow which was swollen, tender, and deformed. Circulation and sensation in the extremity were intact, but the elbow was obviously dislocated posteriorly. Dr. Aufranc: Dr. Edward Riseborough will discuss the x-ray films and the management of this severe elbow injury. Dr. Edward J. Riseborough: This patient has sustained a posterior dislocation of the elbow joint with fracture of both the coronoid process of the ulna and the lateral margin of the radial head (Fig 1). Fortunately, the coronoid process fracture is small, the fragment measuring about
Fellowships, Grants, Awards
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Fellowships, Grants, Awards Get access JNCI: Journal of the National Cancer Institute, Volume 87, Issue 13, 5 July 1995, Page 1031, https://doi.org/10.1093/jnci/87.13.1031 Published: 05 July 1995
A Treatise on the Science and Practice of Midwifery.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sexual Potency in Elderly Men Before and After Prostatectomy
Authors: Alex L. Finkle
Journal: JAMA (1966)

Review of sexual activity before and after prostatectomy was made of 102 patients treated in private practice. Some decline in sexual activity with advancing age was found, but a substantial number (67%) were potent preoperatively and 84% of these retained potency postoperatively, irrespective of surgical route for prostatectomy. A willing sexual partner was the most important factor in maintenance of sexual potency after prostatectomy. Physicians' interest in, and knowledge of, sexual function among prostatectomy candidates is urgently suggested.
CHICAGO MEDICAL SOCIETY.
Authors: Wm E Quine
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Home Delivery Controversy
Authors: Howard G. McQuarrie
Journal: JAMA (1980)

The controversy of home vs hospital delivery has been thoroughly reviewed by Adamson and Gare elsewhere in this issue (p 1732). Their dissertation is timely and accurate, pointing out that a schema to resolve the controversy cannot be simplistic. The accelerated availability of regional planning and hospital-based technology to improve the outcome of pregnancy is meeting resistance, sometimes extremely emotional resistance, from some patients and physicians. To make matters more difficult, they may not always accept scientific arguments as the final basis for decision. This has led to a rigid polarization of views from both sides of the controversy, leaving a vacuum in place of communication, educational opportunity, and quiet resolution of the problem in the interest of the mother and child. So does the historical pendulum swing until a crisis occurs and reactive regulation with arbitrary decisions is mandated. The home birth controversy provides a rare opportunity for physicians