AB0636 Relationship between organ damage and impairment of health-related quality of life in patients with Behçet’s Syndrome: results from a longitudinal extension of the BODI Project.
Authors: A. Floris, R. Laconi, G. Espinosa, G. Lopalco, L. Serpa Pinto, N. Kougkas, J. Sota, A. Lo Monaco, M. Govoni, L. Cantarini, G. Bertsias, J. Correia, F. Iannone, R. Cervera, C. Vasconcelos, A. Mathieu, A. Cauli, M. Piga
Journal: Annals of the Rheumatic Diseases (2022)

Background Preventing accrual of organ damage represents a primary goal in the treatment of Behçet’s Syndrome (BS), as it may result in impairment of other outcomes, including the health-related quality of life (HR-QoL). Objectives The objective of this study was to investigate whether the recent accrual of organ damage, rather than its extent at a single time point, correlate with an impairment of the HR-QoL. Methods A sub-analysis of data from patients recruited in the longitudinal phase of the BODI Project validation cohort was performed. The HR-QoL and damage were measured by the Short-form 36 questionnaire (SF-36) and the BS Overall Damage Index (BODI), respectively, at the baseline visit and at a follow-up (FU) 24 ±3 months later. Then the possible increase of damage over FU was assessed by calculating the difference between the BODI score (Δ-BODI) in the two visits. Then, the relationship between the Δ-BODI and the individual and summary domains of the SF-36 was analysed by building multivariate regression models, including age, gender, concomitant fibromyalgia and/or depression, current disease activity as assessed by the BDCAF, as confounding variables. Results From the BODI validation cohort, 147 patients were recruitable for this sub-analysis;73 (49.8%) were males. The mean (SD) age and disease duration at enrolment were, respectively, 46.2 (12.4) and 13.4 (10.1) years. BODI score did not influence the SF-36 domains assessed at the baseline visit. In contrast, a significant correlation was recorded between the Δ-BODI and the following SF-36 domains: physical function (PF) (β -0.158 for 1 unit increase in BODI score, p 0.025), role physical (RP) (β -0.150, p 0.044), general health (GH) (β -0.199, p 0.004), role emotional (RE) (β -0.180, p 0.001), mental health (MH) (β -0.244, p 0.001), and the mental components summary (MCS) (-0.203, p 0.008)(Figure 1). Gender, age, fibromyalgia and disease activity were also confirmed to significantly influence HR-QoL (Table 1). Table 1. Multiple regression for the assessment of the relationship between Δ-BODI and SF-36 domains Δ-BODI Male Age FBM DPR BDCAF Physical function (PF) -0.158 (p 0.025 ) 0.180 (p 0.010) -0.299 (p&lt;0.001) -0.358 (p&lt;0.001) -- (p 0.552) -0.141 (p 0.044) Role-physical (RP) -0.150 (p 0.044 ) 0.154 (p 0.039) -0.212 (p 0.001) -0.278 (p&lt;0.001) -- (0.086) -0.251 (p&lt;0.001) Body-pain (BP) -- 0.868 0.266 (p&lt;0.001) -0.286 (p&lt;0.001) -0.276 (p&lt;0.001) -- (p 0.799) -262 (p&lt;0.001) General health (GH) -0.199 (p 0.004 ) 0.187 (p 0.010) -- (0.136) -0.296 (p&lt;0.001) -- (0.861) -0.352 (p&lt;0.001) Vitality (VT) -- (p 0.868) 0.238 (p 0.001) -0.178 (p 0.008) -0.213 (0.002) -- (p 0.855) -0.371 (p&lt;0.001) Social function (SF) -- (p 0.239) 0.299 (p 0.004) -0.166 (p 0.024) -0.242 (p 0.001) -- (0.831) -0.202 (p 0.010) Role emotional (RE) -0.180 0.003 ) 0.158 (p 0.047) -0.157 (p 0.048) -0.233 (p 0.003) -- (0.531) -0.191 (p 0.016) Mental health (MH) -0.244 (p 0.001 ) -- (p 0.142) -- (p 0.142) -0.292 (p&lt;0.001) -- (p 0.073) -0.254 (p 0.001) Physical Component Summary (PCS) -- 0.105 0.229 (p 0.001) -0.298 (p&lt;0.001) -0.296 (p&lt;0.001) -0.254 (p&lt;0.001) Mental Component Summary (MCS) -0.203 (p 0.008 ) -- (p 0.068) -- (0.246) -0.255 (p 0.001) -- (0.122) -0.302 (p&lt;0.001) FBM: fibromyalgia; DPR: depression Conclusion The recent accrual of organ damage, rather than its extent assessed in a single visit, is associated with impairment of different aspects of heath related quality of life, especially those mental related. Such phenomenon is similar to that observed in other systemic rheumatic disease, may be due to coping mechanisms. Disclosure of Interests None declared