tbuckley/cabot-search huggingface dataset:
IODOPHILIA.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1136: p53-induced miR-15a/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer
Authors: Lei Shi, Rene Jackstadt, Helge Siemens, Huihui Li, Thomas Kirchner, Heiko Hermeking
Journal: Cancer Research (2014)

Abstract The transcription factor AP4 mediates epithelial-mesenchymal transition (EMT) in colorectal cancer (CRC) but its control in this setting is not fully understood. Here we report the definition of a double-negative feedback loop involving AP4 and miR-15a/16-1 that regulates EMT and metastatic progression. In CRC cells, AP4 was downregulated by DNA damage in a p53-dependent manner. AP4 downregulation by p53 was mediated indirectly by the tumor suppressive microRNAs miR-15a and miR-16-1, which targeted the 3′-UTR of AP4 mRNA, induced mesenchymal-epithelial transition (MET) and inhibited CRC cell migration and invasion. The downregulation of AP4 was necessary for MET induction by miR-15a/16-1. In tumor xenoplants, ectopic miR-15a/16-1 suppressed formation of lung metastases. Furthermore, AP4 directly suppressed expression of miR-15a/16-1. In clinical specimens of colorectal cancer, miR-15a levels inversely correlated with AP4 protein levels shown previously to correlate with distant metastasis and poor survival. In summary, our results define a double-negative feedback loop involving miR-15a/16-1 and AP4 that stabilizes epithelial and mesenchymal states, respectively, that may determine metastatic prowess. Citation Format: Lei Shi, Rene Jackstadt, Helge Siemens, Huihui Li, Thomas Kirchner, Heiko Hermeking. p53-induced miR-15a/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1136. doi:10.1158/1538-7445.AM2014-1136
Book Review Fetal and Neonatal Physiology Edited by Richard A. Polin and William W. Fox. 1884 pp. in two volumes, illustrated. Philadelphia, W.B. Saunders, 1992. $300. ISBN 0–7216–2963–6 . Schaffer and Avery's Diseases of the Newborn Sixth edition. Edited by H. William Taeusch, Roberta A. Ballard, and Mary Ellen Avery. 1115 pp., illustrated. Philadelphia, W.B. Saunders, 1991. $125. ISBN 0–7216–2476–6 . Primary Care of the Preterm Infant By Judy C. Bernbaum and Marsha Hoffman-Williamson, with Jo…
Authors: Claude Régnier
Journal: New England Journal of Medicine (1992)
Third Sardinian Meeting on Chemical Carcinogenesis
Journal: JNCI Journal of the National Cancer Institute (1985)

Third Sardinian Meeting on Chemical Carcinogenesis Get access JNCI: Journal of the National Cancer Institute, Volume 74, Issue 5, May 1985, Pages 1153–1154, https://doi.org/10.1093/jnci/74.5.1153-e Published: 01 May 1985
A Correction of a Statement Respecting Gout in Hospital Records
Authors: Peter Bent, Henry Christian
Journal: New England Journal of Medicine (1932)

in the report of the meeting of the Harvard Medical Society the follow- ing sentence appears: "It was remarked that this is the first typical case of gout in the hospital rec- ords since the advent of prohibition."This is an error.Gout is a condition which is admitted to the medical wards of the Peter Bent Brigham Hospital at about the average rate of 3 or 4 per year, there being admitted in 1924 8 cases, 1925 3, 1926 1, 1927 0, 1928 1, 1929 3, 1930 0, 1931 5.I am making the cor- rection in order that there be no perpetuation of the idea indicated by the sentence that I have quoted.Very truly yours,
THE EFFECT OF THE CARDIAC MYOSIN ACTIVATOR, MECAMTIV MECARBIL, ON RIGHT VENTRICULAR STRUCTURE AND FUNCTION IN CHRONIC SYSTOLIC HEART FAILURE (COSMIC-HF)
Authors: Tor Biering-Sorensen, Alexander Papolos, John Teerlink, G. Michael Felker, John McMurray, Jason Legg, Fady Malik, Narimon Honarpour, Christopher Kurtz, Scott D. Solomon
Journal: Journal of the American College of Cardiology (2020)
<i>Erratum:</i> Vol. 69, No. 50
Journal: MMWR Morbidity and Mortality Weekly Report (2021)

In the report "The Advisory Committee on Immunization Practices' Interim Recommendation for Use of Pfizer-BioNTech COVID-19 Vaccine -United States, December 2020," on page 1922, in the third paragraph, the third and fourth sentences should have read Consistent high efficacy (≥92%) was observed across age, sex, race, and ethnicity categories and among persons with underlying medical conditions.Efficacy was similarly high in a secondary analysis including participants both with or without evidence of previous SARS-CoV-2 infection.Although numbers of observed hospitalizations and deaths were low, the available data were consistent with reduced risk for these severe outcomes among vaccinated persons compared with that among placebo recipients.
Biomarker Monitoring of a Population Residing near Uranium Mining Activities
Authors: William W. Au, Richard G. Lane, Marvin S. Legator, Elbert B. Whorton, Gregg S. Wilkinson, Gary J. Gabehart
Journal: Environmental Health Perspectives (1995)

We investigated whether residents residing near uranium mining operations (target population), who are potentially exposed to toxicants from mining waste, have increased genotoxic effects compared with people residing elsewhere (reference population). Population surveys were conducted, and 24 target and 24 reference residents were selected. The selected subjects and controls were matched on age and gender and they were nonsmokers. Blood samples were collected for laboratory studies. The standard cytogenetic assay was used to determine chromosome aberration frequencies, and the challenge assay was used to investigate DNA repair responses. We found that individuals who resided near uranium mining operations had a higher mean frequency of cells with chromosome aberrations and higher deletion frequency but lower dicentric frequency than the reference group, although the difference was not statistically significant. After cells were challenged by exposure to gamma-rays, the target population had a significantly higher frequency of cells with chromosome aberrations and deletion frequency than the reference group. The latter observation is indicative of abnormal DNA repair response in the target population.
Errata
Authors: W Aspland, Harbour Grace, ; London, W Mr, Ghazi Dera, ; Anti-Quuck Khan, London Burnes, W Bulloch, H Borland, De Bireh, Messrs Blackwoud, London Sons, T Brown, F London, London Buloch, E Barnes, T Buwes, ] Seine, Bay Mr, Mr Brett, Brisbane Brockway, H Barnard, Mr Barling, Lancaster Charity, Organization Soiety, J Clarke, W Caie, Dublin Cannay, Mr Collins, Mr Childe, Mr Christy, E Colbeck, Mr Comber
Journal: BMJ (1903)
Ward 402
Authors: John L. McClenahan
Journal: JAMA (1973)

Mary, a pretty 11-year-old, is admitted to the pediatric ward of a university hospital. She has acute lymphocytic leukemia. Her father, a laboratory technician, wanted her just to die at home with something for the pain. Everyone in the hospital is doing research. Every patient is bled every day, almost ritualistically, it seems to provide specimens for the bustling laboratories. Question: What is the purpose of Mary's treatment? To induce a remission by whatever means or to keep the girl as comfortable as possible? Dr. Glasser, a pediatrician, explores these questions, fully alert to their moral and dramatic possibilities. He examines the guises of expediency and the day-to-day conflict between scientism and resignation, with its shattering effect on patient, parent, and staff. He shows us the mystification and gradual alienation of parents who come to feel that they have surrendered their sick children to a strictly objective research program. Dr.
The Role of In?uenza Vaccination and its Impact on Cardiology
Authors: Rodolfo Llamas
Journal: Clinical Cardiology and Cardiovascular Interventions (2021)

Inﬂuenza is a common, but serious illness, which has a burden of disease all over the world. It is estimated that there are about 3 to 5 million severe case of the disease that may require hospital admission, and around 290,000 to 650,000 deaths in each seasonal outbreak. The whole population is at risk of becoming ill due to inﬂuenza. However, children and patients with chronic illnesses, such as those with cardiovascular diseases or multiple disorders, have a higher risk of developing complications. The prevention of infection due to inﬂuenza through vaccination is well known in the childhood population, but also has an important role in the maintenance of health and prevention of mortality and morbidity in patients with cardiovas- cular disease. This is due to known cardioprotective mechanisms, mainly in the prevention of acute myocardial infarction or heart failure. Nowadays, immunization must be included in the comprehensive secondary prevention in these patients
Abstract P299: BMI and BP Predict Brachial Distensibility in Healthy Adolescents and Young Adults
Authors: Elaine M Urbina, Philip R Khoury, Lisa J Martin, Lawrence M Dolan
Journal: Circulation (2012)

Introduction: CV risk-factor (CVRF) related increase in arterial stiffness is associated with adverse CV events in adults. Cross-sectional studies in youth show a relationship between CVRF and arterial stiffness. Longitudinal data are lacking. Hypothesis: CVRFs will predict decreased brachial artery distensibility (BrachD). Methods: Demographics, anthropometrics, BP, fasting glucose, insulin, lipids and BrachD were measured in 425 healthy youth in a school-based longitudinal cohort (age 17.4 +2.1 yrs, 41% male, 61% Caucasian). Anthropometrics, BP and BrachD were repeated 2.1 + 0.3 years later. Mean values for baseline and follow-up variables were evaluated by paired t-test. Characteristics of subjects with decrease in BrachD (N=167) were compared by t-test with subjects without BrachD decrease. The multivariable model to determine predictors of follow-up BrachD contained baseline and change of age, sex, BMI, MAP, HR, baseline lipids, glucose and insulin. Results: Over 2 years, the cohort increased in HT, WT, BMI, SBP and BrachD (all p&lt;0.02). Predictors of decrease in BrachD were greater baseline and change in BMI, MAP and HR (R 2 = 0.36, model p &lt;0.0001, parameter p&lt; 0.02, BrachD at follow-up = 2.7 + 0.04*Age at baseline + 0.4*Sex (male=1, female=2) − 0.02 Age at baseline*Sex − 0.33*BMI at baseline − 0.02*BMI change - 0.005*MAP at baseline - 0.004*MAP change - 0.002*HR at baseline - 0.003*HR change). BMI at baseline and change in BMI contributed the majority of the variance in BrachD at follow-up (16 and 4%). Subjects with decrease in BrachD were more likely to have gained more BMI (1.3 vs 0.6 kg/m 2 ) or increased more in MAP (0.8 vs −1.3 mmHg) and HR (1.1 vs −2.0 beats/min, all p&lt;0.002). Conclusions: Development of obesity with subsequent changes in BP and HR may lead to development of arterial dysfunction. Prevention of obesity may be the most important approach to improve the CV health of adolescents and young adults.
Incorrect Data in Text
Journal: JAMA (2020)

read "Funnel plot asymmetry was not observed for outcomes reported in at least 10 trials, except for cardiovascular mortality (P = .049for Egger test)."In the first paragraph of the Discussion, the data reported for cardiovascular mortality should have read "RR, 0.82 after 2-6 years [95% CI, 0.71 to 0.94]; I 2 = 0%; ARD, -0.20% [95% CI, -0.35% to -0.05%]," and the NNT for cardiovascular death should have been reported as 500.In Table 3, "Key Question 1a" section, "Summary of Findings" column, the data reported for cardiovascular mortality should have read "RR, 0.82 [95% CI, 0.71-0.94];I 2 = 0%; ARD, -0.20%; NNT, 500."Incorrect data also appeared in Figure 3 and the online supplement.This article was corrected online.
A Functional Magnetic Resonance Imaging Study of Social Cognition in Schizophrenia During an Acute Episode and After Recovery
Authors: Kwang-Hyuk Lee
Journal: American Journal of Psychiatry (2006)

Objective: Difficulty with social interactions is a characteristic of schizophrenia. The authors used functional magnetic resonance imaging (fMRI) to investigate brain activation changes during a social cognition paradigm in patients with schizophrenia during and after an acute episode and their association with social and executive function. Method: In a longitudinal study design, 14 patients with schizophrenia experiencing an acute episode had an fMRI scan. They returned for a follow-up scan after clinical improvement. Fourteen healthy comparison subjects were also scanned twice with approximately the same time interval between scans as in the patient group. The authors employed a social cognition fMRI paradigm involving empathic and forgivability judgments. Schizophrenia symptoms, social functioning and illness insight scales, and the Wisconsin Card Sorting Test were used to examine whether improvement on these measures was associated with recovery of brain activation in response to the social cognition paradigm. Results: After recovery from the acute episode, patients exhibited increased activation in the left medial prefrontal cortex, which was, in turn, significantly correlated with improved insight and social functioning. Decreased symptom severity and improved performance on the Wisconsin Card Sorting Test were not significantly associated with increased left medial prefrontal cortex activation. Conclusions: This is the first study to the authors' knowledge to use a social cognition paradigm to reveal improved left medial prefrontal cortex activation in schizophrenia after recovery from an acute episode. These results suggest that restored left medial prefrontal cortex activation may mediate improvement of insight and social functioning in patients with schizophrenia.
Operative Cystoscopy.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Minibronchoalveolar Lavage by Respiratory Therapists
Authors: Marin H. Kollef
Journal: Annals of Internal Medicine (1996)

Letters15 January 1996Minibronchoalveolar Lavage by Respiratory TherapistsMarin H. Kollef, MDMarin H. Kollef, MDWashington University School of Medicine; St. Louis, MO 63110Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-2-199601150-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I agree that we currently lack adequate clinical data supporting the routine use of bronchoscopic or nonbronchoscopic lower-airway sampling for the evaluation of suspected ventilator-associated pneumonia [1]. This is due, in part, to the limitations of these techniques, including the need for physician performance of bronchoscopy, and the lack of outcome data suggesting any benefit from the use of these techniques compared with routine clinical management. Prospective trials are required to determine the clinical efficacy and cost-effectiveness of these diagnostic techniques.Antibiotic administration is recognized as an important limitation of lower-airway sampling methods, which primarily result in false-negative ...References1. Niederman MS, Torres A, Summer W. Invasive diagnostic testing is not needed routinely to manage suspected ventilator-associated pneumonia. Am J Respir Crit Care Med. 1994; 150:565-79. Google Scholar2. Torres A, el-Ebiary M. Pardo L, Gonzalez J, de la Bellacasa JP, Ramirez J, et al. Validation of different techniques for the diagnosis of ventilator-associated pneumonia. Comparison with immediate postmortem pulmonary biopsy. Am J Respir Crit Care Med. 1994; 149:324-31. Google Scholar3. Rouby JJ, Martin De Lassale E, Poete P, Nicholas MH, Bodin L, Jarlier V, et al. Nosocomial bronchopneumonia in the critically ill. Histologic and bacteriologic aspects. Am Rev Respir Dis. 1992; 146:1059-66. Google Scholar4. el-Ebiary M, Torres A, Gonzalez J, de la Bellacasa JP, Garcia C, Jimenez de Anta MT, et al. Quantitative cultures of endotracheal aspirates for the diagnosis of ventilator-associated pneumonia. Am Rev Respir Dis. 1993; 148:1552-7. Google Scholar5. Marquette CH, Herengt F, Saulnier F, Nevierre R, Mathieu D, Courcol R, et al. Protected specimen brush in the assessment of ventilator-associated pneumonia. Selection of a certain lung segment for bronchoscopic sampling is unnecessary. Chest. 1993; 103:243-7. Google Scholar Author, Article, and Disclosure InformationAuthors: Marin H. Kollef, MDAffiliations: Washington University School of Medicine; St. Louis, MO 63110 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1996Volume 124, Issue 2 Page: 275 Keywords Antibiotics Bronchoscopy Clinical trials Diagnostic techniques Lungs Patients Pneumonia Prospective studies Ventilator associated pneumonia ePublished: 15 August 2000 Issue Published: 15 January 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Safety and Efficacy of Lenabasum in a Phase II, Randomized, Placebo‐Controlled Trial in Adults With Systemic Sclerosis
Authors: Robert Spiera, Laura Hummers, Lorinda Chung, Tracy M. Frech, Robyn Domsic, Vivien Hsu, Daniel E. Furst, Jessica Gordon, Maureen Mayes, Robert Simms, Robert Lafyatis, Viktor Martyanov, Tammara Wood, Michael L. Whitfield, Scott Constantine, Elizabeth Lee, Nancy Dgetluck, Barbara White
Journal: Arthritis & Rheumatology (2020)

To assess the safety and efficacy of lenabasum in diffuse cutaneous systemic sclerosis (dcSSc).A randomized, double-blind, placebo-controlled, phase II study was conducted at 9 SSc clinics in the US. Adults with dcSSc of ≤6 years' duration who were receiving stable standard-of-care treatment were randomized to receive lenabasum (n = 27) or placebo (n = 15). Lenabasum doses were 5 mg once daily, 20 mg once daily, or 20 mg twice daily for 4 weeks, followed by 20 mg twice daily for 8 weeks. Safety and efficacy were assessed at weeks 4, 8, 12, and 16.Adverse events (AEs) occurred in 63% of the lenabasum group and 60% of the placebo group, with no serious AEs related to lenabasum. Compared to placebo, lenabasum treatment was associated with greater improvement in the American College of Rheumatology Combined Response Index in diffuse cutaneous Systemic Sclerosis (CRISS) score and other efficacy outcome measures that assessed overall disease, skin involvement, and patient-reported function. The median CRISS score increased in the lenabasum group during the study, reaching 0.33, versus 0.00 in the placebo group, at week 16 (P = 0.07 by 2-sided mixed-effects model repeated-measures analysis). Gene expression in inflammation and fibrosis pathways was reduced, and inflammation and fibrosis were improved on histologic evaluation of skin biopsy specimens, in the lenabasum group compared to the placebo group (all P ≤ 0.05).Despite a short trial duration in a small number of patients in this phase II study in dcSSc, our findings indicate that lenabasum improves efficacy outcomes and underlying disease pathology with a favorable safety profile.
Eustrongylas Gigas.
Authors: Robert C. M. Lewis
Journal: JAMA (1898)

Centerburg, Ohio, April 11, 1898. <h3>To the Editor:</h3> —On page 717 of theJournalan article appears on the subject of "Eustrongylus Gigas," by Dr. G. W. Morehouse. Having been a neighbor for almost twenty years, and for a number of years the family physician of the patient mentioned, I presume some correction in regard to Dr. M.'s statements might be in order from me. Mr. H. (the patient) is a rather robust man in appearance to the person who would stop with a superficial survey, but to the physician who examines the case will come a revelation, for the man has fatty degeneration and the usual train of general symptoms that follow in the wake of such conditions. He was a cavalryman in the late war, and since the war has been a merchant until a year ago. Prominent among the symptoms of the above named condition is the
The right to be treated against her will
Authors: None Anonymous
Journal: BMJ (1994)

... My sister's inconsistent and intermittent treatment over the past eight years is largely a result of her own indecision and the inconsistencies of her abnormal mental state. The professionals who might have taken control of the situation as her health and functioning deteriorated have not done so and I must presume that they believe they cannot do so. I do not think her case is unique. There are many more people living in the community who are severely ill and are being deprived of treatment they need.