tbuckley/cabot-search huggingface dataset:
42065 Improvement in Itch, Symptoms, and Quality of Life With Upadacitinib Through Week 16 in Adults and Adolescents With Atopic Dermatitis: Results From Phase 3 Studies (Measure Up 1, Measure Up 2, and AD Up)
Authors: Peter Lio, Lawrence F. Eichenfield, Danielle Marcoux, Wan-Ju Lee, Henrique D. Teixeira, Eliza M. Raymundo, Amy E. Gamelli, Ayman Grada, Xiaofei Hu, Alan D. Irvine
Journal: Journal of the American Academy of Dermatology (2023)

Background: Atopic dermatitis (AD) is characterized by intense itch and symptoms that adversely impact quality of life (QoL). Upadacitinib is a selective Janus kinase-1 inhibitor approved for moderate-to-severe AD. We assessed the effect of once daily oral upadacitinib (15 or 30 mg) on patient-reported outcomes for adults and adolescents during the double-blind, placebo-controlled periods of Measure Up 1 (NCT03569293), Measure Up 2 (NCT03607422), and AD Up (NCT03568318). Assessments included itch (Worst Pruritus Numerical Rating Scale); skin pain and symptom severity (AD Symptom Scale); symptom frequency (Patient Oriented Eczema Measure); and sleep, daily activities, and emotional state (AD Impact Scale). Post-hoc analysis of 2240 adults and 344 adolescents randomized patients was performed. By week 2, more patients receiving upadacitinib achieved a clinically relevant response in itch, skin pain, symptom severity, symptom frequency, sleep, daily activities, and emotional state vs placebo across studies among adults (upadacitinib 15 mg: 30.8-87.3%; upadacitinib 30 mg: 38.0-89.9%; placebo: 2.1- 43.1%; nominal P<.001 for all comparisons) and adolescents (upadacitinib 15 mg: 19.4-82.9%; upadacitinib 30 mg: 35.3-97.6%; placebo: 0-41.0%; nominal P<.05 for 37/42 comparisons). These trends continued through week 16 where response rates for all outcomes improved with upadacitinib vs placebo in adults (upadacitinib 15 mg: 42.9-80.4%; upadacitinib 30 mg: 60.9-84.6%; placebo: 10.1- 38.1%; nominal P<.001 for all comparisons) and adolescents (upadacitinib 15 mg: 33.3-78.0%; upadacitinib 30 mg: 50.0-85.7%; placebo: 2.8-43.6%; nominal P<.05 for 41/42 comparisons). These findings highlight the rapid, sustained efficacy of once daily oral upadacitinib in improving symptom burden and QoL in adults and adolescents with moderate-to-severe AD.
43508 Optimal Nodal Management and Patterns of Failure for Merkel Cell Carcinoma Patients with Clinically Occult Regional Nodal Metastases Detected by Sentinel Lymph Node Biopsy
Authors: Natalie Garcia, Victoria Jiminez, Kristy Broman, Mehran Yusuf, Ashley Holder, John Dubay
Journal: Journal of the American Academy of Dermatology (2023)
41496 The Role of Topical Nasal Decongestant Oxymetazoline as a Novel Therapeutic Option for Post- Acne Erythema: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial
Authors: Chanudda Washrawirul, Thanaporn Puaratana-arunkon, Nopadon Noppakun, Pravit Asawanonda, Chanat Kumtornrut
Journal: Journal of the American Academy of Dermatology (2023)
41531 A Phase 1, Randomized, Double-Blind, Single-Dose Comparative Pharmacokinetic Study Comparing SB17 (Proposed Ustekinumab Biosimilar) with Reference Ustekinumab in Healthy Subjects
Authors: Hansol Jeong, Taeseung Kang, Jiyoon Lee, Seongsik Im
Journal: Journal of the American Academy of Dermatology (2023)
43802 Bimekizumab in patients with moderate to severe plaque psoriasis: Injection site reactions through two years of the BE RADIANT phase 3b trial and open-label extension with one-year comparison to secukinumab
Authors: Jennifer Soung, David Rosmarin, Anna López Ferrer, Edward Lain, Phoebe Rich, Katy White, Fabienne Staelens, Balint Szilagyi, Delphine Deherder, Nina Magnolo
Journal: Journal of the American Academy of Dermatology (2023)
41945 Incidence and Factors Associated with Acne in Adolescents on Masculinizing Hormone Therapy: A Single-Site Retrospective Cohort Study
Authors: Sarah Gold, Lena Chu, Carlyn Harris, Leslie Lawley, Pranav Gupta, Vin Tangpricha, Michael Goodman, Howa Yeung
Journal: Journal of the American Academy of Dermatology (2023)
42828 Efficacy and safety of roflumilast cream 0.3% in patients with chronic plaque psoriasis: pooled PASI and PASI-HD results from the DERMIS-1 and DERMIS-2 Phase 3 Trials
Authors: Kim Papp, Mark Lebwohl, H. Chih-ho Hong, Leon Kircik, David Pariser, Bruce Strober, Gerald Krueger, David Krupa, Patrick Burnett, David Berk, Robert Higham
Journal: Journal of the American Academy of Dermatology (2023)
43928 Long-term Safety and Efficacy of Risankizumab for the Treatment of Moderate to-Severe Plaque Psoriasis: Interim Analysis of Results From the LIMMitless Open-label Extension Trial Up to 5 Years of Follow-up
Authors: Kim A. Papp, Mark G. Lebwohl, Lluís Puig, Mamitaro Ohtsuki, Stefan Beissert, Jie Liu, Tianshuang Wu, Ranjeeta Sinvhal, Ahmed M. Soliman, Michael M. Chen, Andrew Blauvelt
Journal: Journal of the American Academy of Dermatology (2023)
44047 Long Term Real-World Treat-to-Target Skin Clearance and Maintenance of Response with Risankizumab in Patients with Moderate to Severe Psoriasis From the CorEvitas Psoriasis Registry
Authors: April W. Armstrong, Laura K. Ferris, Kristina Callis Duffin, Jud C. Janak, Adam P. Sima, Thomas Eckmann, Huzefa Photowala, Manish Patel, Vishvas Garg, Bruce E. Strober
Journal: Journal of the American Academy of Dermatology (2023)
44184 Misalignment in Patient and Physician Perspectives on Disease Burden in Chronic Spontaneous Urticaria (CSU): A Real-World Survey in the US
Authors: Stephanie Mehlis, Dhaval Patil, Michael Wells, Merin Kuruvilla, James Hetherington, Eleanor Wrest, Aaron Keal, Giselle Mosnaim
Journal: Journal of the American Academy of Dermatology (2023)
The use of Acceptance and Commitment Therapy (ACT) in informal caregivers of people with dementia and other long-term or chronic conditions: A systematic review and conceptual integration
Authors: Golnaz L. Atefi, Marjolein E. de Vugt, Rosalia J.M. van Knippenberg, Michael E. Levin, Frans R.J. Verhey, Sara Laureen Bartels
Journal: Clinical Psychology Review (2023)

Informal caregivers are the primary source of support for adults with chronic conditions and disabilities. Empirical research highlights chronic stress and other risks of adverse outcomes of caregiving. Acceptance and Commitment Therapy (ACT) is an emerging evidenced-based practice that shows promise in improving an array of outcomes, theoretically by increasing psychological flexibility as the primary process of change. Research has begun to evaluate ACT among informal caregivers of adult populations, and a systematic review is now needed to summarise this evidence base. Electronic searches from five databases, including PubMed, PsycInfo, Embase, CINAHL, and Cochrane Library, yielded an initial 7896 hits, which after screening for inclusion criteria, resulted in 21 clinical trials. Studies were coded to synthesise the feasibility, effectiveness, and quality of evidence. Findings show that ACT was reported to be largely feasible and acceptable. However, the efficacy of ACT was mixed, with a more consistent pattern for informal caregivers of people with dementia. Several methodological quality issues limited the findings. However, theoretical synthesis and preliminary evidence support the promising effect of ACT in subgroups of informal caregivers. Research on the process of change, as well as larger-scale, methodologically rigorous trials, are needed to consolidate these findings.
International consensus on patient-centred outcomes in eating disorders
Authors: Amelia Austin, Umanga De Silva, Christiana Ilesanmi, Theerawich Likitabhorn, Isabel Miller, Maria da Luz Sousa Fialho, S Bryn Austin, Belinda Caldwell, Chu Shan Elaine Chew, Sook Ning Chua, Suzanne Dooley-Hash, James Downs, Carine El Khazen Hadati, Beate Herpertz-Dahlmann, Jillian Lampert, Yael Latzer, Paulo P P Machado, Sarah Maguire, Madeeha Malik, Carolina Meira Moser, Elissa Myers, Iris Ruth Pastor, Janice Russell, Lauren Smolar, Howard Steiger, Elizabeth Tan, Eva Trujillo-Chi Vacuán, Mei-Chih Meg Tseng, Eric F van Furth, Jennifer E Wildes, Christine Peat, Tracy K Richmond
Journal: The Lancet Psychiatry (2023)
Associations between paternal versus maternal parenting behaviors and child and adolescent internalizing problems: A systematic review and meta-analysis
Authors: S.J. Manuele, M.B.H. Yap, S.C. Lin, E. Pozzi, S. Whittle
Journal: Clinical Psychology Review (2023)

There is a large evidence base supporting an important role of parenting behavior in influencing youth mental health; however, this literature often fails to capture the potentially unique and interactive role of mothers and fathers. This systematic review and meta-analysis aimed to investigate the role of maternal and paternal parenting behaviors in relation to child and adolescent internalizing problems. Following PRISMA (2020) guidelines, 88 studies were identified. Of these, 47 studies and upward of 65 parent-behavior and child-outcome combinations were examined. Findings indicated a unique role of maternal overprotection in the prediction of child anxiety symptoms. For other parenting behaviors, largely similar associations were found for maternal and paternal parenting behaviors with child and adolescent anxiety, depressive symptoms and broader internalizing problems. There was preliminary support for the interaction of maternal and paternal parenting being important in predicting youth symptoms. Although findings did not strongly substantiate differences in the effects of maternal and paternal parenting practices, with only one significant difference identified, further research would benefit from stronger representation of fathers, to enable a more rigorous and comprehensive understanding of each parent's role, and their interactive influence on internalizing outcomes of their children.
Survival of patients with basal cell carcinoma, squamous cell carcinoma, and squamous cell carcinoma in situ: A whole population study
Authors: Kelley Sharp, Elinborg J. Olafsdottir, Dev R. Sahni, Steve Madsen, Jane M. Grant-Kels, Arni Kristjansson, David W. Hoyt, Jonathan P. Ungar, Alice Frigerio, Jon Gunnlaugur Jonasson, Jonas A. Adalsteinsson
Journal: Journal of the American Academy of Dermatology (2023)
Prevalence of allergic contact dermatitis in children with and without atopic dermatitis: A multicenter retrospective case-control study
Authors: Hadley Johnson, Marcella R. Aquino, Alan Snyder, Reid W. Collis, Katlein Franca, Alina Goldenberg, Jennifer Y. Sui, Dawn Z. Eichenfield, Brittany J. Kozy, Jennifer K. Chen, Chelsea Shope, Ari M. Goldminz, JiaDe Yu
Journal: Journal of the American Academy of Dermatology (2023)
Severity of influenza-associated hospitalisations by influenza virus type and subtype in the USA, 2010–19: a repeated cross-sectional study
Authors: Kelsey M Sumner, Svetlana Masalovich, Alissa O'Halloran, Rachel Holstein, Arthur Reingold, Pam Daily Kirley, Nisha B Alden, Rachel K Herlihy, James Meek, Kimberly Yousey-Hindes, Evan J Anderson, Kyle P Openo, Maya L Monroe, Lauren Leegwater, Justin Henderson, Ruth Lynfield, Melissa McMahon, Chelsea McMullen, Kathy M Angeles, Nancy L Spina, Kerianne Engesser, Nancy M Bennett, Christina B Felsen, Krista Lung, Eli Shiltz, Ann Thomas, H Keipp Talbot, William Schaffner, Ashley Swain, Andrea George, Melissa A Rolfes, Carrie Reed, Shikha Garg
Journal: The Lancet Microbe (2023)

Influenza burden varies across seasons, partly due to differences in circulating influenza virus types or subtypes. Using data from the US population-based surveillance system, Influenza Hospitalization Surveillance Network (FluSurv-NET), we aimed to assess the severity of influenza-associated outcomes in individuals hospitalised with laboratory-confirmed influenza virus infections during the 2010-11 to 2018-19 influenza seasons.
Visual Impairment from Uncorrected Refractive Error among Participants in a Novel Program to Improve Eye Care Access among Low-Income Adults in Michigan
Authors: Olivia J. Killeen, Leslie M. Niziol, Angela R. Elam, Amanda K. Bicket, Denise John, Sarah Dougherty Wood, David C. Musch, Jason Zhang, Leroy Johnson, Martha Kershaw, Maria A. Woodward, Paula Anne Newman-Casey
Journal: Ophthalmology (2023)
MRI Digital Artery Volume Index (DAVIX) as a surrogate outcome measure of digital ulcer disease in patients with systemic sclerosis: a prospective cohort study
Authors: Michael Hughes, Stefano Di Donato, Klodian Gjeloshi, Giuseppina Abignano, Fiammetta Danzo, Giovanni Lettieri, Enrico De Lorenzis, Dominic Bertham, Philip O'Connor, Olga Kubassova, Jamshid Dehmeshki, Francesco Del Galdo
Journal: The Lancet Rheumatology (2023)

Vascular fibrosis is a key manifestation of systemic sclerosis that leads to the narrowing of small and medium arteries, causing vascular clinical manifestations including digital ulcers and pulmonary arterial hypertension. We investigated the potential of the MRI-based Digital Artery Volume Index (DAVIX) as a surrogate outcome measure of vascular fibrosis by using it to quantify and predict the burden of digital ulcer disease in patients with systemic sclerosis.
Role of plasma exchange in ANCA-associated vasculitis – Authors' reply
Authors: Sebastián Juan Magri, Manuel Francisco Ugarte-Gil, Maria Lorena Brance, Luis Felipe Flores-Suárez, Daniel Gerardo Fernández-Ávila, Marina Scolnik, Emilia Inoue Sato, Alexandre Wagner S de Souza, Lina María Saldarriaga-Rivera, Alejandra Magdalena Babini, Natalia V Zamora, María Laura Acosta Felquer, Facundo Vergara, Leandro Carlevaris, Santiago Scarafia, Enrique Roberto Soriano Guppy, Sebastian Unizony
Journal: The Lancet Rheumatology (2023)
Lymph node dendritic cells harbor inducible replication-competent HIV despite years of suppressive ART
Authors: Riddhima Banga, Francesco Andrea Procopio, Erica Lana, Gregory T. Gladkov, Isabelle Roseto, Elizabeth M. Parsons, Xiaodong Lian, Marie Armani-Tourret, Maxime Bellefroid, Ce Gao, Annamaria Kauzlaric, Mathilde Foglierini, Oscar Alfageme-Abello, Susanna H.M. Sluka, Olivia Munoz, Andrea Mastrangelo, Craig Fenwick, Yannick Muller, Catherine Gerald Mkindi, Claudia Daubenberger, Matthias Cavassini, Rafael Trunfio, Sébastien Déglise, Jean-Marc Corpataux, Mauro Delorenzi, Mathias Lichterfeld, Giuseppe Pantaleo, Matthieu Perreau
Journal: Cell Host & Microbe (2023)

Although gut and lymph node (LN) memory CD4 T cells represent major HIV and simian immunodeficiency virus (SIV) tissue reservoirs, the study of the role of dendritic cells (DCs) in HIV persistence has long been limited to the blood due to difficulties to access lymphoid tissue samples. In this study, we show that LN migratory and resident DC subpopulations harbor distinct phenotypic and transcriptomic profiles. Interestingly, both LN DC subpopulations contain HIV intact provirus and inducible replication-competent HIV despite the expression of the antiviral restriction factor SAMHD1. Notably, LN DC subpopulations isolated from HIV-infected individuals treated for up to 14 years are transcriptionally silent but harbor replication-competent virus that can be induced upon TLR7/8 stimulation. Taken together, these results uncover a potential important contribution of LN DCs to HIV infection in the presence of ART.
41602 Achievement of National Psoriasis Foundation (NPF) treatment targets and acceptable responses among patients with psoriasis treated with ixekizumab versus other biologics in head-to- head clinical trials
Authors: April Armstrong, Andrew Blauvelt, Kim A. Papp, Lawrence J. Green, Meghan Feely, William N. Malatestinic, Kyoungah See, Missy McKean-Matthews, Bruce E. Strober
Journal: Journal of the American Academy of Dermatology (2023)
From Patterns to Proteins: Mass Spectrometry Comes of Age in Glomerular Disease
Authors: Sanjeev Sethi, Jason D. Theis, Lilian M.P. Palma, Benjamin Madden
Journal: Journal of the American Society of Nephrology (2023)

Laser capture microdissection and mass spectrometry (LCM/MS) is a technique that involves dissection of glomeruli from paraffin-embedded biopsy tissue, followed by digestion of the dissected glomerular proteins by trypsin, and subsequently mass spectrometry to identify and semiquantitate the glomerular proteins. LCM/MS has played a crucial role in the identification of novel types of amyloidosis, biomarker discovery in fibrillary GN, and more recently discovery of novel target antigens in membranous nephropathy (MN). In addition, LCM/MS has also confirmed the role for complement proteins in glomerular diseases, including C3 glomerulopathy. LCM/MS is now widely used as a clinical test and considered the gold standard for diagnosis and typing amyloidosis. For the remaining glomerular diseases, LCM/MS has remained a research tool. In this review, we discuss the usefulness of LCM/MS in other glomerular diseases, particularly MN, deposition diseases, and diseases of complement pathways, and advocate more routine use of LCM/MS at the present time in at least certain diseases, such as MN, for target antigen detection. We also discuss the limitations of LCM/MS, particularly the difficulties faced from moving from a research-based technique to a clinical test. Nonetheless, the role of LCM/MS in glomerular diseases is expanding. Currently, LCM/MS may be used to identify the etiology in certain glomerular diseases, but in the future, LCM/MS can play a valuable role in determining pathways of complement activation, inflammation, and fibrosis.
Deep learning-based lung sound analysis for intelligent stethoscope
Authors: Dong-Min Huang, Jia Huang, Kun Qiao, Nan-Shan Zhong, Hong-Zhou Lu, Wen-Jin Wang
Journal: Military Medical Research (2023)

Abstract Auscultation is crucial for the diagnosis of respiratory system diseases. However, traditional stethoscopes have inherent limitations, such as inter-listener variability and subjectivity, and they cannot record respiratory sounds for offline/retrospective diagnosis or remote prescriptions in telemedicine. The emergence of digital stethoscopes has overcome these limitations by allowing physicians to store and share respiratory sounds for consultation and education. On this basis, machine learning, particularly deep learning, enables the fully-automatic analysis of lung sounds that may pave the way for intelligent stethoscopes. This review thus aims to provide a comprehensive overview of deep learning algorithms used for lung sound analysis to emphasize the significance of artificial intelligence (AI) in this field. We focus on each component of deep learning-based lung sound analysis systems, including the task categories, public datasets, denoising methods, and, most importantly, existing deep learning methods, i.e., the state-of-the-art approaches to convert lung sounds into two-dimensional (2D) spectrograms and use convolutional neural networks for the end-to-end recognition of respiratory diseases or abnormal lung sounds. Additionally, this review highlights current challenges in this field, including the variety of devices, noise sensitivity, and poor interpretability of deep models. To address the poor reproducibility and variety of deep learning in this field, this review also provides a scalable and flexible open-source framework that aims to standardize the algorithmic workflow and provide a solid basis for replication and future extension: https://github.com/contactless-healthcare/Deep-Learning-for-Lung-Sound-Analysis .
A Bioresorbable and Conductive Scaffold Integrating Silicon Membranes for Peripheral Nerve Regeneration
Authors: Pengcheng Sun, Yanjun Guan, Can Yang, Hanqing Hou, Shuang Liu, Boyao Yang, Xiangling Li, Shengfeng Chen, Liu Wang, Huachun Wang, Yunxiang Huang, Xing Sheng, Jiang Peng, Wei Xiong, Yu Wang, Lan Yin
Journal: Advanced Healthcare Materials (2023)

Peripheral nerve injury represents one of the most common types of traumatic damage, severely impairing motor and sensory functions, and posttraumatic nerve regeneration remains a major challenge. Electrical cues are critical bioactive factors that promote nerve regrowth, and bioartificial scaffolds incorporating conductive materials to enhance the endogenous electrical field have been demonstrated to be effective. The utilization of fully biodegradable scaffolds can eliminate material residues, and circumvent the need for secondary retrieval procedures. Here, a fully bioresorbable and conductive nerve scaffold integrating N-type silicon (Si) membranes is proposed, which can deliver both structural guidance and electrical cues for the repair of nerve defects. The entire scaffold is fully biodegradable, and the introduction of N-type Si can significantly promote the proliferation and production of neurotrophic factors of Schwann cells and enhance the calcium activity of dorsal root ganglion (DRG) neurons. The conductive scaffolds enable accelerated nerve regeneration and motor functional recovery in rodents with sciatic nerve transection injuries. This work sheds light on the advancement of bioresorbable and electrically active materials to achieve desirable neural interfaces and improved therapeutic outcomes, offering essential strategies for regenerative medicine.
Induced Abortion and the Risk of Rh Sensitization
Authors: Sarah Horvath, Zhen-Yu Huang, Nathanael C. Koelper, Christian Martinez, Patricia Y. Tsao, Ling Zhao, Alisa B. Goldberg, Curtiss Hannum, Mary E. Putt, Eline T. Luning Prak, Courtney A. Schreiber
Journal: JAMA (2023)

Importance While population-level data suggest Rh immunoglobulin is unnecessary before 12 weeks’ gestation, clinical evidence is limited. Thus, guidelines vary, creating confusion surrounding risks and benefits of Rh testing and treatment. As abortion care in traditional clinical settings becomes harder to access, many people are choosing to self-manage and need to know if ancillary blood type testing is necessary. Objective To determine how frequently maternal exposure to fetal red blood cells (fRBCs) exceeds the most conservative published threshold for Rh sensitization in induced first-trimester abortion. Design, Setting, and Participants Multicenter, observational, prospective cohort study using high-throughput flow cytometry to detect circulating fRBCs in paired maternal blood samples before and after induced first-trimester abortion (medication or procedural). Individuals undergoing induced first-trimester abortion before 12 weeks 0 days’ gestation were included. Paired blood samples were available from 506 participants who underwent either medical (n = 319 [63.0%]) or procedural (n = 187 [37.0%]) abortion. Exposure Induced first-trimester abortion. Main Outcomes and Measures The primary outcome was the proportion of participants with fRBC counts above the sensitization threshold (125 fRBCs/5 million total RBCs) after induced first-trimester abortion. Results Among the 506 participants, the mean (SD) age was 27.4 (5.5) years, 313 (61.9%) were Black, and 123 (24.3%) were White. Three of the 506 participants had elevated fRBC counts at baseline; 1 of these patients had an elevated fRBC count following the abortion (0.2% [95% CI, 0%-0.93%]). No other participants had elevated fRBC counts above the sensitization threshold after induced first-trimester abortion. The median change from baseline was 0 fRBCs, with upper 95th and 99th percentiles of 24 and 35.6 fRBCs, respectively. Although there was a strong association between the preabortion and postabortion fRBC counts, no other baseline characteristic was significantly associated with postabortion fRBC count. Conclusions and Relevance Induced first-trimester abortion is not a risk factor for Rh sensitization, indicating that Rh testing and treatment are unnecessary before 12 weeks’ gestation. This evidence may be used to inform international guidelines for Rh immunoglobulin administration following first-trimester induced abortion.