tbuckley/cabot-search huggingface dataset:
Arthritis and Rheumatism, New York
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rational responses to meeting the challenge of family practice
Authors: W. R. Willard
Journal: JAMA (1967)

A year ago at this congress, I had the privilege of presenting a progress report in behalf of the Ad Hoc Committee on Family Practice. The report of that Committee has now been published and is generally available. The Council on Medical Education, which sponsored the Ad Hoc Committee's study, has endorsed the recommendations. They have been endorsed also by the House of Delegates of the American Medical Association at its November 1966 meeting in Las Vegas, which charged the Council of Medical Education with implementing the recommendations. Based upon these actions by the Council and the House of Delegates, it would appear that medicine, through its official spokesmen at the highest policy level, has responded favorably to the challenge of family practice as presented by the Ad Hoc Committee. It is one thing, however, to receive such endorsements from the Council and the House of Delegates; it is another
Increased PTHrP and Decreased Estrogens Alter Bone Turnover but Do Not Reproduce the Full Effects of Lactation on the Skeleton
Authors: Laleh Ardeshirpour, Susan Brian, Pamela Dann, Joshua VanHouten, John Wysolmerski
Journal: Endocrine Reviews (2010)

During lactation, calcium is mobilized from the maternal skeleton to supply the breast for milk production. This results in rapid but fully reversible bone loss. Prior studies have suggested that PTHrP, secreted from the breast, and estrogen deficiency, due to suckling-induced central hypogonadism, combine to trigger bone resorption. To determine whether this combination was sufficient to explain bone loss during lactation, we raised PTHrP levels and decreased levels of estrogens in nulliparous mice. PTHrP was infused via osmotic minipumps and estrogens were decreased either by using leuprolide, a long-acting GnRH agonist, or by surgical ovariectomy (OVX). Bone mineral density declined by 23.2 ± 1.3% in the spine and 16.8 ± 1.9% in the femur over 10 d of lactation. This was accompanied by changes in trabecular architecture and an increase in both osteoblast and osteoclast numbers. OVX and PTHrP infusion both induced a modest decline in bone mineral density over 10 d, but leuprolide treatment did not. The combination of OVX and PTHrP was more effective than either treatment alone, but there was no interaction between PTHrP and leuprolide. None of the treatments reproduced the same degree of bone loss caused by lactation. However, both forms of estrogen deficiency led to an increase in osteoclasts, whereas infusion of PTHrP increased both osteoblasts and osteoclasts. Therefore, although the combination of PTHrP and estrogen deficiency contributes to bone loss, it is insufficient to reproduce the full response of the skeleton to lactation, suggesting that other factors also regulate bone metabolism during this period.
Science and Seizures: New Light on Epilepsy and Migraine
Journal: JAMA (1941)

This book apparently was meant for popular and medical consumption. There are two parts. Part one discusses convulsive seizures and consists of twenty chapters. Part two discusses headache seizures and consists of eight chapters. The author states that this publication can supplement the advice given by the physician or help the layman whose interest "may be a result of his desire to keep abreast of modern thought in medical matters or those who are handicapped by ill health or by popular ignorance." These thoughts are splendid if one is writing about a specific disease with specific etiologic factors. For symptoms like convulsions, on which numerous scientific contributions have been made for the past fifty years and for which, even at this date, no specific etiologic factors have been found, it is extremely questionable whether they can be discussed from a layman's point of view. The layman is not able to
Dermatopathology
Authors: Elson B. Helwig
Journal: JAMA (1967)

This is a welcome new book on dermatopathology, written, as the author states, for those who are interested in dermatopathology in its broadest aspects. It is basically a personal work reflecting heavily the extensive experience of the author, who wrote all but two of the 38 chapters. The general plan includes three headings for each disease process. The first, "Definition," includes more than this designation would imply and covers the historical and clinical aspects as well. Under "Histopathology" the author describes the histologic changes seen in his own experience and often compares his observations with those in the literature. The final heading, "Diagnosis and Pathogenesis," covers the differential diagnosis of the particular entity. In this section the emphasis is usually not on the histologic aspects but on the disease as a whole. Certain rare conditions and ancillary information are described in fine print. Names of diseases and synonyms are printed
Diagnostic and therapeutic technology assessment. Use of Teflon preparations for urinary incontinence and vesicoureteral reflux
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Structure and Function of the Somatosensory System: A Neurotoxicological Perspective
Authors: Joseph C. Arezzo, Herbert H. Schaumburg, Peter S. Spencer
Journal: Environmental Health Perspectives (1982)

The somatosensory system comprises those elements of the peripheral nervous system (PNS) and the central nervous system (CNS) subserving the modalities of touch, vibration, temperature, pain and kinesthesia. Specific modalities can be associated with unique peripheral receptors, peripheral axons of stereotyped diameter and specific central projection pathways. Several features of the somatosensory system render regions of it vulnerable to a wide variety of toxicants. The present report highlights these features and , furthermore, suggests that analysis of these regions is invaluable in studying the three most common varieties of toxic neuropathy: toxic distal axonopathy, toxic myelinopathy and toxic sensory neuronopathy.
NHS review
Authors: A R Bull
Journal: BMJ (1989)

the mean arterial pressure is reasonable.'Measurements of peripheral vascular resistance and cardiac output in our patients confirmed this relation.The diagnosis of electromechanical dissociation in these circumstances is therefore extremely difficult, and resuscitation should not be abandoned until meaningful haemodynamic data have been obtained.Cuff blood pressure is often meaningless in these circumstances, and resuscitation should not be abandoned with this as the sole criterion.I would also remind others of recent British studies that confirm that age alone is not a prognostic indicator for survival from cardiac arrest.4`It is the nature of the underlying rhythm that is of greatest importance.
Classic Pages
Journal: Circulation Research (1968)

and rapid, it produced a more or less conspicuous regurgitation as in fig.6 B. We would like to emphasize again that the big wave registered by the hot-wire at the beginning of the tetanus is Jiot an increase of the inflow of blood but a regurgitation (back-flow) since it is completely cut out by means of a valve, while no other characteristics of the curve show any change.We have had no practical experience with the thermostromuhr, but we would like to make the
Publisher Correction: Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry
Authors: Sandra Sanchez-Roige, Pierre Fontanillas, Sarah L. Elson, Anita Pandit, Ellen M. Schmidt, Johanna R. Foerster, Gonçalo R. Abecasis, Joshua C. Gray, Harriet de Wit, Lea K. Davis, James MacKillop, Abraham A. Palmer
Journal: Nature Neuroscience (2019)
Pseudomonas Folliculitis Acquired From a Health Spa Whirlpool
Authors: William F. Sausker, John L. Aeling, James E. Fitzpatrick, Franklyn N. Judson
Journal: JAMA (1978)

Three cases of an unusual<i>Pseudomonas</i>skin infection acquired from a health spa whirlpool were reported, and an epidemiologic survey showed 17 additional cases. This dermatosis is characterized by the abrupt onset of urticarial papules and superficial and deep papulopustules that spare only the head and neck and occur eight to 48 hours after using the whirlpool. Cultures from one patient's pustules and from the spa whirlpool environment were positive for<i>P aeruginosa</i>, serotype 0-11. The condition cleared in all but one patient, without treatment, within seven to ten days. This patient continues to have recurrent follicular pustules three months after exposure. Samples from whirlpools at six other selected establishments were also positive for<i>P aeruginosa</i>. (<i>JAMA</i>239:2362-2365, 1978)
Renovascular hypertension and horseshoe kidney
Authors: J. G. Golden
Journal: JAMA (1976)

RECENTLY, it has been suggested that a vascular lesion that affects only a portion of one kidney may have etiologic importance.<sup>1</sup>We report a case of hypertension in which regional renal renin elevation and a stenotic lesion of an artery supplying a segment of a solitary horseshoe kidney appeared to be responsible for the observed elevation of blood pressure. To the best of our knowledge, this constellation of clinical, radiologic, and laboratory findings has not been previously reported. <h3>Report of a Case</h3> A 63-year-old man had apparently been well until May 1974, when he experienced a ten-minute episode of dizziness and unsteadiness of gait. Results of neurological examination were normal, but his blood pressure was 220/130 mm Hg. Therapy with hydrochlorothiazide failed to reduce the hypertension satisfactorily. He was admitted to the San Diego Veterans Administration Hospital with a second episode of dizziness, diplopia, and intermittent ataxia. His blood
Letter: Research on the fetus
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The COMMENTARY covered everything from German measles to the Scopes trial—everything, that is, except abortus research. The investigators in the Boston case (<i>New Engl J Med</i>288:1219, 1973) administered drugs to human fetuses in utero, drugs that were therapeutic neither for mother nor fetus. Proposed National Institutes of Health guidelines would prohibit such activity, but not autopsies and not organ or tissue donation. The Helsinki Declaration restricted nontherapeutic research on live human subjects, particularly those in a dependent position, when the research is harmful. The issue, then, is whether we are going to violate this principle in the name of progress.
Aerosolized Pentamidine
Authors: Eran Bellin
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 March 1989Aerosolized PentamidineEran Bellin, MDEran Bellin, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-5-408_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:In their editorial on aerosolized pentamidine, Armstrong and Bernard (1) confuse two ethical responsibilities of physicians and thereby render an unethical proscription. The medical community has the responsibility to identify useful therapeutic agents and to encourage their use. The methodology of the double-blind, randomized, controlled clinical trial is well developed, and the information obtained from it may be of the highest value. In the absence of criterion standard information, however, the practicing physician has an ethical responsibility to make the best decision possible using the best available information. The information available is usually of lower quality, for...Reference1. Armstrong D and Bernard E. Aerosol pentamidine [Editorial]. Ann Intern Med. 1989;109:852-4. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Eran Bellin, MDAffiliations: Montefiore Medical Center Bronx, NY 10467 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1989Volume 110, Issue 5Page: 408-408KeywordsClinical trials ePublished: 1 December 2008 Issue Published: 1 March 1989 PDF downloadLoading ...
Annotated List of Reviews in Medicine
Authors: E M MacKay, L L MacKay
Journal: Annual Review of Medicine (1956)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More
528O CC-90011 in patients (Pts) with advanced solid tumours (STs) and relapsed/refractory non-Hodgkin lymphoma (R/R NHL): Updated results of a phase I study
Authors: A. Hollebecque, J.S. de Bono, S. Salvagni, R. Plummer, P. Niccoli, J. Capdevila, G. Curigliano, V. Moreno, F. de Braud, M. López-Brea, P. Martin-Romano, E. Baudin, M. Arias, J. de Alvaro, J. Parra-Palau, T. Sánchez-Pérez, I. Aronchik, E. Filvaroff, M. Lamba, Z. Nikolova
Journal: Annals of Oncology (2020)
DUODENORENAL FISTULA
Authors: George C. Biondi
Journal: JAMA (1935)

A fistulous communication between the duodenum and the pelvis of the right kidney, though described only casually even in the more elaborate treatises on urology, constitutes an extremely rare clinical entity. That its potentiality has been recognized since time immemorial is indicated by the fact that even Hippocrates makes mention of it in his Opera Omnia;yet in all these centuries I have found but three cases recorded in the entire medical literature. The earliest report is that of Rayer,<sup>1</sup>in which he describes the case of Dr. Campaignac: A tailoress, aged 45, was admitted to the hospital, Jan. 10, 1835, and died March 6 of the same year without operation. The duodenorenal communication was discovered at autopsy. Turner<sup>2</sup>reports the case of a youth, aged 18, admitted to St. George's Hospital with severe hematuria and advanced tuberculous disease of the lungs. "At autopsy the right
Department of Error
Authors: Lei Zhang, Jian Zhou, Zhiqing Zhao, Zaiping Jing
Journal: The Lancet (2016)

but more attention should be paid to the harm caused by false advertisement.To prevent similar tragedies in future, the following aspects should be taken into consideration.First, internet regulators should strengthen regulation and monitoring of false advertisements, and legislation should have strict state-level laws to severely penalise the advertiser and the publisher of false advertisement.Second, internet companies should undertake social responsibility, and assess advertisers' legitimacy.Companies should not pursue profit at the cost of public health.Google-the biggest multinational internet company-ranks search results based on the relevance to the user's search terms, and this seems a better approach.Third, public knowledge on health and their ability to distinguish between real and false advertisements need to be improved.Advertisements are not necessarily always for good products.
Error in Conflict of Interest Disclosures
Authors: Shinjiro Hirose
Journal: JAMA Surgery (2019)

Ryan Howard, MD; Brian Fry, MS; Vidhya Gunaseelan, MBA, MS, MHA; Jay Lee, MD; Jennifer Waljee, MD, MS, MPH; Chad Brummett, MD; Darrell Campbell Jr, MD; Elizabeth Seese, MS; Michael Englesbe, MD; Joceline Vu, MD
THE TREATMENT OF MALIGNANT TUMORS BY INOCULATIONS OF ERYSIPELAS.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor.
Authors: D Wu, J Yang, W M Pardridge
Journal: Journal of Clinical Investigation (1997)

Peptide radiopharmaceuticals are potential imaging agents for brain disorders, should these agents be enabled to undergo transport through the blood-brain barrier (BBB) in vivo. Radiolabeled Abeta1-40 images brain amyloid in tissue sections of Alzheimer's disease autopsy brain, but this peptide radiopharmaceutical cannot be used to image brain amyloid in vivo owing to negligible transport through the BBB. In these studies, 125I-Abeta1-40 was monobiotinylated (bio) and conjugated to a BBB drug delivery and brain targeting system comprised of a complex of the 83-14 monoclonal antibody (mAb) to the human insulin receptor, which is tagged with streptavidin (SA). A marked increase in rhesus monkey brain uptake of the 125I-bio-Abeta1-40 was observed after conjugation to the 8314-SA delivery system at 3 h after intravenous injection. In contrast, no measurable brain uptake of 125I-bio-Abeta1-40 was observed in the absence of a BBB drug delivery system. The peptide radiopharmaceutical was degraded in brain with export of the iodide radioactivity, and by 48 h after intravenous injection, 90% of the radioactivity was cleared from the brain. In conclusion, these studies describe a methodology for BBB drug delivery and brain targeting of peptide radiopharmaceuticals that could be used for imaging amyloid or other brain disorders.
Stop industry interference, save lives
Authors: None The Lancet Global Health
Journal: The Lancet Global Health (2019)

Japan, Jordan, Bangladesh, and Lebanon are lagging in implementing measures to protect their public health policy making efforts from tobacco industry interference, according to the first ever Global Tobacco Industry Interference Index. The report, published last month by global industry watchdog, Stopping Tobacco Organizations and Products (STOP), used publicly available information to rank 33 countries from all regions in their overall efforts to guard against industry meddling.
Acute suicidal depression associated with use of timolol
Authors: B. T. Nolan
Journal: JAMA (1982)

<h3>To the Editor.—</h3> Timolol maleate (Timoptic), a topical β-blocking agent for lowering intraocular pressure, has gained widespread acceptance as a safe and effective drug. Since its introduction, various side effects have been reported, albeit at an acceptable incidence.<sup>1</sup>Most of the systemic side effects described are common to all β-blockers and are presumably the result of absorption into the circulation. Uncommon but recognized side effects of this group include depression, paranoia, and psychosis.<sup>2</sup>Although mild CNS effects have been reported with timolol, including anxiety, disorientation, fatigue, and anorexia, major reactions have not been noted. A case of acute suicidal depression thought to be directly related to the use of timolol at normal dosage is described. <h3>Report of a Case.—</h3> A 65-year-old woman entered the E. S. Harkness Eye Institute, New York, with a hyphemia of 30% and an intraocular tension of 42. The patient suffered from adult-onset diabetes
CLASSIFICATION OF RACE AND ETHNICITY: Implications for Public Health
Authors: V. M. Mays
Journal: Annual Review of Public Health (2002)

Emerging methods in the measurement of race and ethnicity have important implications for the field of public health.Traditionally, information on race and/or ethnicity has been integral to our understanding of the health issues affecting the U.S. population.We review some of the complexities created by new classification approaches made possible by the inclusion of multiplerace assessment in the U.S. Census and large health surveys.We discuss the importance of these classification decisions in understanding racial/ethnic health and health care access disparities.The trend toward increasing racial and ethnic diversity in the United States will put further pressure on the public health industry to develop consistent and useful approaches to racial/ethnic classifications.