tbuckley/cabot-search huggingface dataset:
EP08.02-048 Crizotinib in ROS1+NSCLC: Long-term OS Analysis in Patients with Brain Metastases Included in the Phase II METROS Trial
Authors: F. Cappuzzo, R. Chiari, M. Tiseo, V. Minotti, F. De Marinis, A. Delmonte, M. Bungaro, D.L. Cortinovis, D. Galetta, L. Bonanno, A. Chella, C. Gridelli, A. Morabito, F. Grossi, E. Bria, D. Giannarelli, G. Fontanini, G. Borra, S. Gori, F. Mazzoni, S. Pilotto, L. Landi
Journal: Journal of Thoracic Oncology (2022)
EP05.02-014 Neoadjuvant Toripalimab Combination in Patients with Stage IIB-IIIB NSCLC: A Single-Arm, Phase 2 Trial (Renaissance Study)
Authors: S. Yan, J. Chen, J. Wang, C. Lv, J. Bi, X. Yang, S. Li, Y. Wang, X. Li, Y. Yang, N. Wu
Journal: Journal of Thoracic Oncology (2022)
EP08.01-007 Real-World Outcomes of Patients with Advanced Lung Adenocarcinoma Treated with First-Line Chemo-Immunotherapy in Italy
Authors: A. Leonetti F. Perrone, M. Puntoni, P. Bordi, G. Maglietta, C. Carpana, F. Gelsomino, F. Passiglia, C. Genova, M. Montrone, E. Caliman, G. Cerea, G. Pasello, F. Cecere, A. Manzo, V. Adamo, F. Citarella, L. Toschi, A. Gelibter, F. Rastelli, A. Carta, A. Guida, A. Camerini, F. Paoloni, F. Bertolini, M. Tiseo
Journal: Journal of Thoracic Oncology (2022)
EP08.01-107 The Increase of Blood Intratumor Heterogeneity Is Associated with Unfavorable Outcomes of ICIs Plus Chemotherapy in NSCLC
Authors: J. Zhou, M. Bao, G. Gao, Y. Cai, L. Wu, L. Lei, J. Zhao, X. Ji, Y. Huang, C. Su
Journal: Journal of Thoracic Oncology (2022)
EP14.05-022 The Drug Induced Interstitial Lung Disease in Chemoimmunotherapy for Extensive-Stage Small Cell Lung Cancer
Authors: R. Takamiya, K. Fukuda, N. Katsurada, Y. Kawa, M. Satouchi, K. Kaneshiro, M. Matsumoto, Y. Hatakeyama, R. Dokuni, K. Matsumura, M. Katsurada, K. Nakata, S. Yoshimura, M. Tachihara
Journal: Journal of Thoracic Oncology (2022)
EP08.02-064 ASTRIS China: A Real-world Study of Osimertinib in Patients with EGFR T790M Positive Non-small-cell Lung Cancer (NSCLC)
Authors: Q. Zhou, H.-L. Zhang, L.-Y. Jiang, Y.-K. Shi, Y. Chen, J.-M. Yu, C.-C. Zhou, Y. He, Y.-P. Hu, Z.-A. Liang, Y.-Y. Pan, W.-L. Zhuo, Y. Song, G. Wu, G.-Y. Chen, Y. Lu, C.-Y. Zhang, C.-Y. Zhang, Y.-P. Zhang, Y. Chen, S. Lu, Y.-L. Wu
Journal: Journal of Thoracic Oncology (2022)
EP08.01-036 Low-dose EGFR-TKIs Directly Induce Maturation and Functional Activity of Human Dendritic Cells in an EGFR-independent manner
Authors: H. Inoue, H. Tsutsumi, K. Okamura, K. Ota, Y. Yoneshima, E. Iwama, K. Tanaka, I. Okamoto
Journal: Journal of Thoracic Oncology (2022)
EP07.01-001 Molecular Profiling Predicts Outcomes in Patients With Resected Malignant Pleural Mesothelioma
Authors: C.D. Rolfo, D. de Miguel Perez, U. Mallapelle, W. Grier, F. Pepe, G. Troncone, M. Culligan, K.A. Scilla, R. Mehra, A. Russo, P. Mohindra, A. Sachdeva, F.R. Hirsch, A. Wolf, J. Friedberg, E.M. Pickering
Journal: Journal of Thoracic Oncology (2022)
RARE COMPLICATIONS OF TYPHOID FEVER.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In vitro and in vivo evidence that the switch from calcineurin to mTOR inhibitors may be a strategy for immunosuppression in Epstein–Barr virus–associated post-transplant lymphoproliferative disorder
Authors: Constantin J. Thieme, Malissa Schulz, Patrizia Wehler, Moritz Anft, Leila Amini, Arturo Blàzquez-Navarro, Ulrik Stervbo, Jochen Hecht, Mikalai Nienen, Anna-Barbara Stittrich, Mira Choi, Panagiota Zgoura, Richard Viebahn, Michael Schmueck-Henneresse, Petra Reinke, Timm H. Westhoff, Toralf Roch, Nina Babel
Journal: Kidney International (2022)
Awards, Appointments, Announcements
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Awards, Appointments, Announcements Get access JNCI: Journal of the National Cancer Institute, Volume 84, Issue 23, 2 December 1992, Pages 1778–1780, https://doi.org/10.1093/jnci/84.23.1778 Published: 02 December 1992
Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs
Authors: Stefania Crippa, Anastasia Conti, Valentina Vavassori, Samuele Ferrari, Stefano Beretta, Silvia Rivis, Roberto Bosotti, Serena Scala, Stefania Pirroni, Raisa Jofra-Hernandez, Ludovica Santi, Luca Basso-Ricci, Ivan Merelli, Pietro Genovese, Alessandro Aiuti, Luigi Naldini, Raffaella Di Micco, Maria Ester Bernardo
Journal: Molecular Therapy (2022)

RNA-seq (GSE168834) and BAR-Seq (GSE206900)."The authors apologize for the inconvenience, and this error has been corrected online.
Self-activated arsenic manganite nanohybrids for visible and synergistic thermo/immuno-arsenotherapy
Authors: Yanhua Zhai, Ming Liu, Tao Yang, Jie Luo, Chaogang Wei, Junkang Shen, Xue Song, Hengte Ke, Peng Sun, Miao Guo, Yibin Deng, Huabing Chen
Journal: Journal of Controlled Release (2022)
Elevations of Cardiac Troponin I Associated With Myocarditis
Authors: Stacy C. Smith, Jack H. Ladenson, Jay W. Mason, Allan S. Jaffe
Journal: Circulation (1997)

Background Endomyocardial biopsy is currently the standard method used to diagnose myocarditis. However, it is invasive and has a low diagnostic yield. Because the histological diagnosis of myocarditis requires the presence of myocyte injury, we sought to determine whether measurement of cardiac troponin I (cTnI), which is a serum marker with high sensitivity and specificity for cardiac myocyte injury, could aid in the diagnosis of myocarditis. Methods and Results To validate this approach, cTnI values were first measured in mice with autoimmune myocarditis. cTnI values were elevated in 24 of 26 mice with myocarditis but were not elevated in any of the control animals ( P &lt;.001). Next, cTnI values were measured in the sera from 88 patients referred to the Myocarditis Treatment Trial and were compared with creatine kinase–MB (CK-MB) values measured in the same patients. cTnI values were elevated in 18 (34%) of 53 patients with myocarditis and in only 4 (11%) of 35 patients without myocarditis ( P =.01). In contrast, CK-MB values were elevated in only 3 (5.7%) of 53 patients with myocarditis and 0 of 35 patients without myocarditis ( P =.27). Thus, elevations of cTnI occurred more frequently than did elevations of CK-MB in patients with biopsy-proven myocarditis ( P =.001). Importantly, elevations of cTnI in patients with myocarditis were significantly correlated with ≤1 month duration of heart failure symptoms ( P =.02), suggesting that the majority of myocyte necrosis occurs early, and thus the window for diagnosis and treatment may be relatively brief. Conclusions cTnI was superior to CK-MB for detection of myocyte injury in myocarditis, and cTnI elevations were substantially more common in the first month after the onset of heart failure symptoms.
Dendritic cell-mimicking scaffolds for ex vivo T cell expansion
Authors: Hye Sung Kim, Tzu-Chieh Ho, Moshe J. Willner, Michael W. Becker, Hae-Won Kim, Kam W. Leong
Journal: Bioactive Materials (2022)

We propose an ex vivo T cell expansion system that mimics natural antigen-presenting cells (APCs) for adoptive cell therapy (ACT). Microfiber scaffolds coated with dendritic cell (DC) membrane replicate physicochemical properties of dendritic cells specific for T cell activation such as rapid recognition by T cells, long duration of T cell tethering, and DC-specific co-stimulatory cues. The DC membrane-coated scaffold is first surface-immobilized with T cell stimulatory ligands, anti-CD3 (αCD3) and anti-CD28 (αCD28) antibodies, followed by adsorption of releasable interleukin-2 (IL-2). The scaffolds present both surface and soluble cues to T cells ex vivo in the same way that these cues are presented by natural APCs in vivo. We demonstrate that the DC-mimicking scaffold promotes greater polyclonal expansion of primary human T cells as compared to αCD3/αCD28-functionalized Dynabead. More importantly, major histocompatibility complex molecules derived from the DC membrane of the scaffold allow antigen-specific T cell expansion with target cell-specific killing ability. In addition, most of the expanded T cells (∼97%) can be harvested from the scaffold by density gradient centrifugation. Overall, the DC-mimicking scaffold offers a scalable, modular, and customizable platform for rapid expansion of highly functional T cells for ACT.
Efficacy and safety of switching from intravenous to oral antibiotics (amoxicillin–clavulanic acid) versus a full course of intravenous antibiotics in neonates with probable bacterial infection (RAIN): a multicentre, randomised, open-label, non-inferiority trial
Authors: Fleur M Keij, René F Kornelisse, Nico G Hartwig, Jacqueline van der Sluijs-Bens, Ron H T van Beek, Arianne van Driel, Linda G M van Rooij, Ilka van Dalen-Vink, Gertjan J A Driessen, Sandra Kenter, Jeannette S von Lindern, Marianne Eijkemans, Gerda M Stam-Stigter, Hongchao Qi, Maartje M van den Berg, Martin G A Baartmans, Laura H van der Meer-Kappelle, Clemens B Meijssen, Obbe F Norbruis, Jojanneke Heidema, Maaike C van Rossem, Paul C P den Butter, Karel Allegaert, Irwin K M Reiss, Gerdien A Tramper-Stranders
Journal: The Lancet Child & Adolescent Health (2022)
The early-life gut microbiome and vaccine efficacy
Authors: Anne Jordan, Simon R Carding, Lindsay J Hall
Journal: The Lancet Microbe (2022)

Vaccines are one of the greatest successes of public health, preventing millions of cases of disease and death in children each year. However, the efficacy of many vaccines can vary greatly between infants from geographically and socioeconomically distinct locations. Differences in the composition of the intestinal microbiome have emerged as one of the main factors that can account for variations in immunisation outcomes. In this Review, we assess the influence of the gut microbiota upon early life immunity, focusing on two important members of the microbiota with health-promoting and immunomodulatory properties: Bifidobacterium and Bacteroides. Additionally, we discuss their immune stimulatory microbial properties, interactions with the host, and their effect on vaccine responses and efficacy in infants. We also provide an overview of current microbiota-based approaches to enhance vaccine outcomes, and describe novel microbe-derived components that could lead to safer, more effective vaccines and vaccine adjuvants.
Detecting motor symptom fluctuations in Parkinson’s disease with generative adversarial networks
Authors: Vishwajith Ramesh, Erhan Bilal
Journal: npj Digital Medicine (2022)

Parkinson's disease is a neurodegenerative disorder characterized by several motor symptoms that develop gradually: tremor, bradykinesia, limb rigidity, and gait and balance problems. While there is no cure, levodopa therapy has been shown to mitigate symptoms. A patient on levodopa experiences cycles in the severity of their symptoms, characterized by an ON state-when the drug is active-and an OFF state-when symptoms worsen as the drug wears off. The longitudinal progression of the disease is monitored using episodic assessments performed by trained physicians in the clinic, such as the Unified Parkinson's Disease Rating Scale (UPDRS). Lately, there has been an effort in the field to develop continuous, objective measures of motor symptoms based on wearable sensors and other remote monitoring devices. In this work, we present an effort towards such a solution that uses a single wearable inertial sensor to automatically assess the postural instability and gait disorder (PIGD) of a Parkinson's disease patient. Sensor data was collected from two independent studies of subjects performing the UPDRS test and then used to train and validate a convolutional neural network model. Given the typical limited size of such studies we also employed the use of generative adversarial networks to improve the performance of deep-learning models that usually require larger amounts of data for training. We show that for a 2-min walk test, our method's predicted PIGD scores can be used to identify a patient's ON/OFF states better than a physician evaluated on the same criteria. This result paves the way for more reliable, continuous tracking of Parkinson's disease symptoms.
Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative
Authors: Ruth Johnson, Yi Ding, Vidhya Venkateswaran, Arjun Bhattacharya, Kristin Boulier, Alec Chiu, Sergey Knyazev, Tommer Schwarz, Malika Freund, Lingyu Zhan, Kathryn S. Burch, Christa Caggiano, Brian Hill, Nadav Rakocz, Brunilda Balliu, Christopher T. Denny, Jae Hoon Sul, Noah Zaitlen, Valerie A. Arboleda, Eran Halperin, Sriram Sankararaman, Manish J. Butte, Clara Lajonchere, Daniel H. Geschwind, Bogdan Pasaniuc
Journal: Genome Medicine (2022)

Abstract Background Large medical centers in urban areas, like Los Angeles, care for a diverse patient population and offer the potential to study the interplay between genetic ancestry and social determinants of health. Here, we explore the implications of genetic ancestry within the University of California, Los Angeles (UCLA) ATLAS Community Health Initiative—an ancestrally diverse biobank of genomic data linked with de-identified electronic health records (EHRs) of UCLA Health patients ( N =36,736). Methods We quantify the extensive continental and subcontinental genetic diversity within the ATLAS data through principal component analysis, identity-by-descent, and genetic admixture. We assess the relationship between genetically inferred ancestry (GIA) and &gt;1500 EHR-derived phenotypes (phecodes). Finally, we demonstrate the utility of genetic data linked with EHR to perform ancestry-specific and multi-ancestry genome and phenome-wide scans across a broad set of disease phenotypes. Results We identify 5 continental-scale GIA clusters including European American (EA), African American (AA), Hispanic Latino American (HL), South Asian American (SAA) and East Asian American (EAA) individuals and 7 subcontinental GIA clusters within the EAA GIA corresponding to Chinese American, Vietnamese American, and Japanese American individuals. Although we broadly find that self-identified race/ethnicity (SIRE) is highly correlated with GIA, we still observe marked differences between the two, emphasizing that the populations defined by these two criteria are not analogous. We find a total of 259 significant associations between continental GIA and phecodes even after accounting for individuals’ SIRE, demonstrating that for some phenotypes, GIA provides information not already captured by SIRE. GWAS identifies significant associations for liver disease in the 22q13.31 locus across the HL and EAA GIA groups (HL p -value=2.32×10 −16 , EAA p -value=6.73×10 −11 ). A subsequent PheWAS at the top SNP reveals significant associations with neurologic and neoplastic phenotypes specifically within the HL GIA group. Conclusions Overall, our results explore the interplay between SIRE and GIA within a disease context and underscore the utility of studying the genomes of diverse individuals through biobank-scale genotyping linked with EHR-based phenotyping.
Invasive Group B Streptococcal Disease in Adults
Authors: Benjamin Schwartz
Journal: JAMA (1991)

<h3>Objective.</h3> —To define the incidence and clinical spectrum of group B streptococcus infection in adults. To characterize groups at increased risk for infection. <h3>Design.</h3> —Retrospective population-based surveillance of group B streptococcus infections occurring in adults. Patients were identified by review of microbiology records at all surveillance area hospital laboratories. Demographic and clinical data were abstracted from patient medical records. <h3>Setting.</h3> —Metropolitan Atlanta, Ga, 1982 through 1983. <h3>Patients.</h3> —We identified 70 adult patients with invasive group B streptococcus infections; 14 infections occurred in pregnant women and 56 in nonpregnant adults. <h3>Results.</h3> —The annual incidence of group B streptococcus infection in men and nonpregnant women was 2.4 cases per 100 000 population. Incidence increased with age and was higher in blacks than in whites. The case-fatality rate was 32%. Group B streptococcus was most often isolated from blood (71%) and soft tissue (16%). Common clinical presentations included skin and soft-tissue infection (36%), bacteremia without focus (34%), pneumonia (11%), arthritis (9%), and endocarditis (9%). Compared with the general population's risk of infection, the risk of infection in persons with diabetes mellitus was increased 10.5-fold (95% confidence interval [Cl], 7.8 to 14.4); in persons with cancer, it was increased 16.4-fold (95% CI, 11.5 to 23.3). <h3>Conclusions.</h3> —Group B streptococcus infections cause serious disease in adults as well as in neonates, providing an additional rationale for vaccine development. Determining the incidence of adult disease and groups at greatest risk will help in focusing prevention efforts. (<i>JAMA</i>. 1991;266:1112-1114)
Strategies for accelerating osteogenesis through nanoparticle-based DNA/mitochondrial damage repair
Authors: Hye Jin Kim, Hui Bang Cho, Sujin Lee, Jiyon Lyu, Hye-Ryoung Kim, Sujeong Lee, Ji-In Park, Keun-Hong Park
Journal: Theranostics (2022)

The efficiency of gene therapy is often dictated by the gene delivery system.Cationic polymers are essential elements of gene delivery systems.The relatively cheap cationic polymer, polyethyleneimine, has high gene delivery efficiency and is often used for gene delivery.However, the efficiency of gene therapy with polyethyleneimine-pDNA polyplex (PEI) is low.Human mesenchymal stem cells transfected with polyethyleneimine and a plasmid carrying the important osteogenic differentiation gene runt-related transcription factor 2 (RUNX2) accumulated DNA double-strand breaks and mitochondrial damage proportional to the amount of polyethyleneimine, reducing viability.Genomic/cellular stabilizer mediating RUNX2 delivery (GuaRD), a new reagent incorporating RS-1 NPs developed in this study, promoted DNA repair and prevented the accumulation of cell damage, allowing the delivery of pRUNX2 into hMSCs.while maintaining genome and mitochondrial stability.DNA damage was significantly lower and the expression of DNA repair-related genes significantly higher with GuaRD than with PEI.In addition, GuaRD improved mitochondrial stability, decreased the level of reactive oxygen species, and increased mitochondrial membrane potential.Osteogenic extracellular matrix (ECM) expression and calcification were higher with GuaRD than with PEI, suggesting improved osteogenic differentiation.These results indicate that lowering the cytotoxicity of PEI and improving cell stability are key to overcoming the limitations of conventional gene therapy, and that GuaRD can help resolve these limitations.
Single-Cell RNA sequencing reveals immune cell dynamics and local intercellular communication in acute murine cardiac allograft rejection
Authors: Zhang Chen, Heng Xu, Yuan Li, Xi Zhang, Jikai Cui, Yanqiang Zou, Jizhang Yu, Jie Wu, Jiahong Xia
Journal: Theranostics (2022)

Rationale: Transplant rejection is a major impediment to long-term allograft survival, in which the actions of immune cells are of fundamental importance.However, the immune cell dynamics and local intercellular communication of acute cardiac allograft rejection are not completely clear.Methods: Here we performed single-cell RNA sequencing on CD45 + immune cells isolated from cardiac grafts and spleens in a model of murine heterotopic heart transplantation.Moreover, we applied unsupervised clustering, functional enrichment analysis, cell trajectory construction and intercellular communication analysis to explore the immune cell dynamics and local intercellular communication of acute cardiac allograft rejection at single-cell level.The effect of CXCR3 antagonist and neutralizing antibody against its ligand on allograft rejection and T cell function was evaluated in murine heart transplantation model.Results: We presented the immune cell landscape of acute murine cardiac allograft rejection at single-cell resolution, and uncovered the functional characteristics and differentiation trajectory of several alloreactive cell subpopulations, including Mki67 hi CTLs, Ccl5 hi CTLs, activated Tregs and alloreactive B cells.We demonstrated local intercellular communication and revealed the upregulation of CXCR3 and its ligands in cardiac allografts.Finally, CXCR3 blockade significantly suppressed acute cardiac allograft rejection and inhibited the alloreactive T cell function.Conclusions: These results provide a new insight into the immune cell dynamics and local intercellular communication of acute cardiac allograft rejection, and suggest CXCR3 pathway may serve as a potential therapeutic target for transplant rejection.
Intratumoral synthesis of transformable metal-phenolic nanoaggregates with enhanced tumor penetration and retention for photothermal immunotherapy
Authors: Xianglian He, Hongfu Zhu, Jiaojiao Shang, Meifeng Li, Yaoyao Zhang, Shicheng Zhou, Guidong Gong, Yunxiang He, Anna Blocki, Junling Guo
Journal: Theranostics (2022)

Rationale: Effective photothermal therapy (PTT) remains a great challenge due to the difficulties of delivering photothermal agents with both deep penetration and prolonged retention at tumor lesion spatiotemporally.Methods: Here, we report an intratumoral self-assembled nanostructured aggregate named FerH, composed of a natural polyphenol and a commercial iron supplement.FerH assemblies possess size-increasing dynamic kinetics as a pseudo-stepwise polymerization from discrete nanocomplexes to microscale aggregates. Results:The nanocomplex can penetrate deeply into solid tumors, followed by prolonged retention (> 6 days) due to the in vivo growth into nanoaggregates in the tumor microenvironment.FerH performs a targeting ablation of tumors with a high photothermal conversion efficiency (60.2%).Importantly, an enhanced immunotherapeutic effect on the distant tumor can be triggered when co-administrated with checkpoint-blockade PD-L1 antibody.Conclusions: Such a therapeutic approach by intratumoral synthesis of metal-phenolic nanoaggregates can be instructive to address the challenges associated with malignant tumors.
Genitourinary Lesions Due to Monkeypox
Authors: Miguel Gomez-Garberi, Pau Sarrio-Sanz, Laura Martinez-Cayuelas, Elisabet Delgado-Sanchez, Sara Bernabeu-Cabezas, Jorge Peris-Garcia, Laura Sanchez-Caballero, Baraa Nakdali-Kassab, Cristina Egea-Sancho, Edgar Humberto Olarte-Barragan, Manuel Angel Ortiz-Gorraiz
Journal: European Urology (2022)