tbuckley/cabot-search huggingface dataset:
Not All Publics Are the Same—A Note on Power, Diversity, and Lived Expertise in Public Deliberation
Authors: Yves Saint James Aquino, Stacy Carter, Chris Degeling
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Public Engagement through Inclusive Deliberation: The Human Genome International Commission and Citizens’ JuriesThis article is referred to by:Response to Open Peer Commentaries on “Public Engagement through Inclusive Deliberation: The Human Genome International Commission and Citizens’ Juries” DISCLOSURE STATEMENTNo potential conflict of interest was reported by the author(s).Additional informationFundingThe authors received funding from the National Health and Medical Research Council Center of Research Excellence (2006-545—WiserHealthcare).
Discrepancies in Estimating Excess Death by Political Party Affiliation During the COVID-19 Pandemic
Authors: Patrick O’Mahen
Journal: JAMA Internal Medicine (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Clinical Research Risks, Climate Change, and Human Health
Authors: Jeff D’Souza, Gabrielle Samuel
Journal: JAMA (2023)

This Viewpoint discusses ways in which clinical research directly and indirectly contributes to anthropogenic climate change, highlights the need for increased scientific soundness and value in research, and calls for the development of tools for calculating the environmental impact of studies and a strategy for ensuring that research does not compromise the rights and welfare of nonparticipants and future generations.
Engaging natural antibody responses for the treatment of inflammatory bowel disease via phosphorylcholine-presenting nanofibres
Authors: Elizabeth J. Curvino, Emily F. Roe, Helena Freire Haddad, Alexa R. Anderson, Mia E. Woodruff, Nicole L. Votaw, Tatiana Segura, Laura P. Hale, Joel H. Collier
Journal: Nature Biomedical Engineering (2023)
Intersecting Moral Spheres, and the Ethical Structures and Functional Roles of Military Medicine: Frameworks in—and for—Reciprocal Rectitude
Authors: Megan Applewhite, Owen Sisbarro, James Giordano
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Spheres of Morality: The Ethical Codes of the Medical Profession DISCLOSURE STATEMENTThe work, view and opinions presented in this essay is that of the authors, and does not necessarily reflect the views and opinions of the United States Department of Defense, or any of the entities and organizations that support the authors’ work. No potential conflict of interest was reported by the author(s).Notes1 Throughout this essay, our reference to “military” settings explicitly refers to those of an open society, in which the role of the military is to protect and serve the polis, as a public good, and as directed by a freely elected political administration.Additional informationFundingMA is supported, in part by funds from the Henry Jackson Foundation for Military Medicine. JG is supported by federal funds from Award UL1TR001409 from the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, through the Clinical and Translational Science Awards Program (CTSA), a trademark of the Department of Health and Human Services, part of the Roadmap Initiative, “Re-Engineering the Clinical Research Enterprise”; National Sciences Foundation Award 2113811 – Amendment ID 001; Henry Jackson Foundation for Military Medicine; Strategic Multilayer Assessment Branch of the Joint Staff, J-39, and US Strategic Command, Pentagon; and Leadership Initiatives. He is currently serving as a Non-Resident Senior Fellow of the Simon Center for the Professional Military Ethic, United States Military Academy, West Point, NY, USA.
Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial
Authors: Raymond Duch, Edward Asiedu, Ryota Nakamura, Thomas Rouyard, Alberto Mayol, Adrian Barnett, Laurence Roope, Mara Violato, Dorcas Sowah, Piotr Kotlarz, Philip Clarke
Journal: Nature Medicine (2023)
Identification of druggable regulators of cell secretion via a kinome-wide screen and high-throughput immunomagnetic cell sorting
Authors: Mahmoud Labib, Zongjie Wang, Yunhye Kim, Sichun Lin, Abdalla Abdrabou, Hanie Yousefi, Pei-Ying Lo, Stéphane Angers, Edward H. Sargent, Shana O. Kelley
Journal: Nature Biomedical Engineering (2023)
Whole-brain in vivo base editing reverses behavioral changes in Mef2c-mutant mice
Authors: Wei-Ke Li, Shu-Qian Zhang, Wan-Ling Peng, Yu-Han Shi, Bo Yuan, Yi-Ting Yuan, Zhen-Yu Xue, Jin-Cheng Wang, Wen-Jian Han, Zhi-Fang Chen, Shi-Fang Shan, Bi-Qing Xue, Jin-Long Chen, Cheng Zhang, Shu-Jia Zhu, Yi-Lin Tai, Tian-Lin Cheng, Zi-Long Qiu
Journal: Nature Neuroscience (2023)
QRISK3 underestimates the risk of cardiovascular events in patients with COPD
Authors: Joseph Emil Amegadzie, Zhiwei Gao, Jennifer K Quint, Richard Russell, John R Hurst, Tae Yoon Lee, Don D Sin, Wenjia Chen, Mona Bafadhel, Mohsen Sadatsafavi
Journal: Thorax (2023)

Background Patients with chronic obstructive pulmonary disease (COPD) are at increased risk of cardiovascular disease (CVD). The extent to which the excess CVD risk is captured by risk factors in QRISK, a widely used CVD risk scoring tool, is not well studied. Methods We created an incidence cohort of diagnosed COPD patients from the United Kingdom (UK) Clinical Practice Research Datalink GOLD database (January 1998–July 2018). The outcome was a composite of fatal or non-fatal CVD events. Sex-specific age-standardised incidence ratios (SIR) were compared with values for the UK primary-care population. The observed 10-year CVD risk was derived using the Kaplan-Meier estimator and was compared with predicted 10-year risk from the QRISK3 tool. Results 13 208 patients (mean age 64.9 years, 45% women) were included. CVD incidence was 3.53 events per 100 person-years. The SIR of CVD was 1.71 (95% CI 1.61 to 1.75) in women and 1.62 (95%CI 1.54–1.64) in men. SIR was particularly high among patients younger than 65 years (women=2.13 (95% CI 1.94 to 2.19); men=1.86 (95% CI 1.74 to 1.90)). On average, the observed 10-year risk was 52% higher than QRISK predicted score (33.5% vs 22.1%). The difference was higher in patients younger than 65 years (observed risk 82% higher than predicted). Conclusion People living with COPD are at a significantly heightened risk of CVD over and beyond their predicted risk. This is particularly the case for younger people whose 10-year CVD risk can be &gt;80% higher than predicted. Risk scoring tools must be validated and revised to provide accurate CVD predictions in patients with COPD.
Evolving Contemporary Management of Atrial Fibrillation in Hypertrophic Cardiomyopathy
Authors: Ethan J. Rowin, Mark. S. Link, Martin S. Maron, Barry J. Maron
Journal: Circulation (2023)

Atrial fibrillation (AF) is the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM) with clinical and subclinical episodes occurring in nearly one-half of patients. AF in HCM historically has been characterized as a decisive disease complication associated with substantial risk for thromboembolic stroke and increased morbidity and mortality. However, there have been many advances in treatment strategy resulting in improved outcomes for this patient group. For example, stroke risk in HCM has been greatly reduced by using systemic oral anticoagulation initiated after the first clinical (symptomatic) AF episode, usually with preference given to direct anticoagulants over warfarin. In contrast, stroke risk scoring systems (such as CHA
Rising global burden of cancer attributable to high BMI from 2010 to 2019
Authors: Darren Jun Hao Tan, Cheng Han Ng, Mark Muthiah, Jie Ning Yong, Douglas Chee, Margaret Teng, Zhen Yu Wong, Rebecca Wenling Zeng, Yip Han Chin, Jiong-Wei Wang, Pojsakorn Danpanichkul, Ruveena Bhavani Rajaram, Ramanuj DasGupta, Hiroyuki Suzuki, Hirokazu Takahashi, Nobuharu Tamaki, Yock Young Dan, Rashid Lui, Ajay Duseja, Mohammad Shadab Siddiqui, Khay Guan Yeoh, Arun Sanyal, Karn Wijarnpreecha, Rohit Loomba, Christos Socrates Mantzoros, Daniel Q. Huang
Journal: Metabolism (2023)
Harnessing human genetics and stem cells for precision cardiovascular medicine
Authors: Arianne Caudal, Michael P. Snyder, Joseph C. Wu
Journal: Cell Genomics (2023)

Human induced pluripotent stem cell (iPSC) platforms are valuable for biomedical and pharmaceutical research by providing tissue-specific human cells that retain patients' genetic integrity and display disease phenotypes in a dish. Looking forward, combining iPSC phenotyping platforms with genomic and screening technologies will continue to pave new directions for precision medicine, including genetic prediction, visualization, and treatment of heart disease. This review summarizes the recent use of iPSC technology to unpack the influence of genetic variants in cardiovascular pathology. We focus on various state-of-the-art genomic tools for cardiovascular therapies-including the expansion of genetic toolkits for molecular interrogation, in vitro population studies, and function-based drug screening-and their current applications in patient- and genome-edited iPSC platforms that are heralding new avenues for cardiovascular research.
Pucotenlimab in patients with advanced mismatch repair-deficient or microsatellite instability-high solid tumors: A multicenter phase 2 study
Authors: Bo Zhang, Yan Song, Suxia Luo, Xianli Yin, Enxiao Li, Hui Wang, Yifu He, Zhihui Liu, Qingxia Fan, Xinjun Liang, Yongqian Shu, Yunpeng Liu, Nong Xu, Shu Zhang, Zhixiang Zhuang, Jingdong Zhang, Xiaoge Kou, Fen Wang, Xiaodong Zhu, Shan Zeng, Ke Wang, Haijun Zhong, Shengmian Li, Yuxian Bai, Junyan Yu, Yiwei Dou, Taiyang Ma, Qian Liu, Jing Huang
Journal: Cell Reports Medicine (2023)
Circadian organization of lipid landscape is perturbed in type 2 diabetic patients
Authors: Flore Sinturel, Simona Chera, Marie-Claude Brulhart-Meynet, Jonathan Paz Montoya, Dirk Jan Stenvers, Peter H. Bisschop, Andries Kalsbeek, Idris Guessous, François R. Jornayvaz, Jacques Philippe, Steven A. Brown, Giovanni D’Angelo, Howard Riezman, Charna Dibner
Journal: Cell Reports Medicine (2023)
Striatal dopamine integrates cost, benefit, and motivation
Authors: Neir Eshel, Gavin C. Touponse, Allan R. Wang, Amber K. Osterman, Amei N. Shank, Alexandra M. Groome, Lara Taniguchi, Daniel F. Cardozo Pinto, Jason Tucciarone, Brandon S. Bentzley, Robert C. Malenka
Journal: Neuron (2023)
Revealing spatial multimodal heterogeneity in tissues with SpaTrio
Authors: Penghui Yang, Lijun Jin, Jie Liao, Kaiyu Jin, Xin Shao, Chengyu Li, Jingyang Qian, Junyun Cheng, Dingyi Yu, Rongfang Guo, Xiao Xu, Xiaoyan Lu, Xiaohui Fan
Journal: Cell Genomics (2023)
Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1
Authors: Leon Tejwani, Neal G. Ravindra, Changwoo Lee, Yubao Cheng, Billy Nguyen, Kimberly Luttik, Luhan Ni, Shupei Zhang, Logan M. Morrison, John Gionco, Yangfei Xiang, Jennifer Yoon, Hannah Ro, Fatema Haidery, Rosalie M. Grijalva, Eunwoo Bae, Kristen Kim, Regina T. Martuscello, Harry T. Orr, Huda Y. Zoghbi, Hayley S. McLoughlin, Laura P.W. Ranum, Vikram G. Shakkottai, Phyllis L. Faust, Siyuan Wang, David van Dijk, Janghoo Lim
Journal: Neuron (2023)

Neurodegeneration is a protracted process involving progressive changes in myriad cell types that ultimately results in the death of vulnerable neuronal populations. To dissect how individual cell types within a heterogeneous tissue contribute to the pathogenesis and progression of a neurodegenerative disorder, we performed longitudinal single-nucleus RNA sequencing of mouse and human spinocerebellar ataxia type 1 (SCA1) cerebellar tissue, establishing continuous dynamic trajectories of each cell population. Importantly, we defined the precise transcriptional changes that precede loss of Purkinje cells and, for the first time, identified robust early transcriptional dysregulation in unipolar brush cells and oligodendroglia. Finally, we applied a deep learning method to predict disease state accurately and identified specific features that enable accurate distinction of wild-type and SCA1 cells. Together, this work reveals new roles for diverse cerebellar cell types in SCA1 and provides a generalizable analysis framework for studying neurodegeneration.
An evolutionary perspective on complex neuropsychiatric disease
Authors: Jon M. McClellan, Anthony W. Zoghbi, Joseph D. Buxbaum, Carolina Cappi, James J. Crowley, Jonathan Flint, Dorothy E. Grice, Suleyman Gulsuner, Conrad Iyegbe, Sanjeev Jain, Po-Hsiu Kuo, Maria Claudia Lattig, Maria Rita Passos-Bueno, Meera Purushottam, Dan J. Stein, Anna B. Sunshine, Ezra S. Susser, Christopher A. Walsh, Olivia Wootton, Mary-Claire King
Journal: Neuron (2023)
Dementia, osteoporosis and fragility fractures: Intricate epidemiological relationships, plausible biological connections, and twisted clinical practices
Authors: C. Ruggiero, M. Baroni, D. Xenos, L. Parretti, I.G. Macchione, V. Bubba, A. Laudisio, C. Pedone, M. Ferracci, R. Magierski, V. Boccardi, R. Antonelli-Incalzi, P. Mecocci
Journal: Ageing Research Reviews (2023)

Dementia, osteoporosis, and fragility fractures are chronic diseases, often co-existing in older adults. These conditions pose severe morbidity, long-term disability, and mortality, with relevant socioeconomic implications. While in the research arena, the discussion remains on whether dementia is the cause or the consequence of fragility fractures, healthcare professionals need a better understanding of the interplay between such conditions from epidemiological and physiological standpoints. With this review, we summarized the available literature surrounding the relationship between cognitive impairment, dementia, and both low bone mineral density (BMD) and fragility fractures. Given the strength of the bi-directional associations and their impact on the quality of life, we shed light on the biological connections between brain and bone systems, presenting the main mediators, including gut microbioma, and pathological pathways leading to the dysregulation of bone and brain metabolism. Ultimately, we synthesized the evidence about the impact of available pharmacological treatments for the prevention of fragility fractures on cognitive functions and individuals' outcomes when dementia coexists. Vice versa, the effects of symptomatic treatments for dementia on the risk of falls and fragility fractures are explored. Combining evidence alongside clinical practice, we discuss challenges and opportunities related to the management of older adults affected by cognitive impairment or dementia and at high risk for fragility fracture prevention, which leads to not only an improvement in patient health-related outcomes and survival but also a reduction in healthcare cost and socio-economic burden.
Engineered smart materials for RNA based molecular therapy to treat Glioblastoma
Authors: Ravi Raj Singh, Indranil Mondal, Taskeen Janjua, Amirali Popat, Ritu Kulshreshtha
Journal: Bioactive Materials (2023)

Glioblastoma (GBM) is an aggressive malignancy of the central nervous system (CNS) that remains incurable despite the multitude of improvements in cancer therapeutics. The conventional chemo and radiotherapy post-surgery have only been able to improve the prognosis slightly; however, the development of resistance and/or tumor recurrence is almost inevitable. There is a pressing need for adjuvant molecular therapies that can successfully and efficiently block tumor progression. During the last few decades, non-coding RNAs (ncRNAs) have emerged as key players in regulating various hallmarks of cancer including that of GBM. The levels of many ncRNAs are dysregulated in cancer, and ectopic modulation of their levels by delivering antagonists or overexpression constructs could serve as an attractive option for cancer therapy. The therapeutic potential of several types of ncRNAs, including miRNAs, lncRNAs, and circRNAs, has been validated in both in vitro and in vivo models of GBM. However, the delivery of these RNA-based therapeutics is highly challenging, especially to the tumors of the brain as the blood-brain barrier (BBB) poses as a major obstacle, among others. Also, since RNA is extremely fragile in nature, careful considerations must be met while designing a delivery agent. In this review we have shed light on how ncRNA therapy can overcome the limitations of its predecessor conventional therapy with an emphasis on smart nanomaterials that can aide in the safe and targeted delivery of nucleic acids to treat GBM. Additionally, critical gaps that currently exist for successful transition from viral to non-viral vector delivery systems have been identified. Finally, we have provided a perspective on the future directions, potential pathways, and target areas for achieving rapid clinical translation of, RNA-based macromolecular therapy to advance the effective treatment of GBM and other related diseases.
CD19-directed CAR T cells as first salvage therapy for large B-cell lymphoma: towards a rational approach
Authors: Peter Dreger, Paolo Corradini, John G Gribben, Bertram Glass, Mats Jerkeman, Marie Jose Kersten, Franck Morschhauser, Alberto Mussetti, Andreas Viardot, Pier Luigi Zinzani, Anna Sureda
Journal: The Lancet Haematology (2023)
Darbepoetin alfa to reduce transfusion episodes in infants with haemolytic disease of the fetus and newborn who are treated with intrauterine transfusions in the Netherlands: an open-label, single-centre, phase 2, randomised, controlled trial
Authors: Isabelle M C Ree, Masja de Haas, Nan van Geloven, Sandra E Juul, Derek de Winter, E J T Verweij, Dick Oepkes, Johanna G van der Bom, Enrico Lopriore
Journal: The Lancet Haematology (2023)
Addition of danicopan to ravulizumab or eculizumab in patients with paroxysmal nocturnal haemoglobinuria and clinically significant extravascular haemolysis (ALPHA): a double-blind, randomised, phase 3 trial
Authors: Jong Wook Lee, Morag Griffin, Jin Seok Kim, Lily Wong Lee Lee, Caroline Piatek, Jun-ichi Nishimura, Cynthia Carrillo Infante, Deepak Jain, Peng Liu, Gleb Filippov, Flore Sicre de Fontbrune, Antonio Risitano, Austin G Kulasekararaj, Wilma Barcellini, Fiorenza Barraco, David Beneitez Pastor, Marcelo Capra, Lee Ping Chew, Lalayanni Chrysavgi, Carlos De Castro, Régis Peffault de la Tour, Michel Michels De Oliveira, Eros Di Bona, Edouard Forcade, Chieh-Lin Fu, Cossor Furha, Anna Gaya Valls, Stavroula Giannouli, Ataulfo Gonzalez-Fernandez, Morag Griffin, Alexander Gural, Emilio Ojeda Gutierrez, Inés Hernández-Rodríguez, Ibrahim Ibrahim, Anna Paola Iori, Tadao Ishida, Jun Ho Jang, Jeong-A Kim, Jin Seok Kim, Toshiyuki Kitano, Hiroshi Kosugi, Natalia Kreiniz, Austin Kulasekararaj, Jong Wook Lee, Lily Wong Lee Lee, Jiri Mayer, Lindsay Mitchell, Yasuo Mori, Kaichi Nishiwaki, Rosario Notaro, Ramiro Nunez, Naoshi Obara, Esther Natalie Oliva, Christopher Patriquin, Viviani Pessoa, Caroline Piatek, Agnieszka Piekarska, Shahzad Raza, Antonio Maria Risitano, Ponlapat Rojnuckarin, Desmond Samuel, Jamile Shammo, Tamar Tadmor, Akiyoshi Takami, Roni Tamari, Louis Terriou, Hitoji Uchiyama, Alessandro Maria Vannucchi, Hiroki Yamaguchi
Journal: The Lancet Haematology (2023)
The role of histone H1.2 in pancreatic cancer metastasis and chemoresistance
Authors: Jianyou Gu, Junfeng Zhang, Renpei Xia, Xianxing Wang, Jiali Yang, Fuming Xie, Qiang Zhou, Jinghe Li, Tao Zhang, Qing Chen, Yingfang Fan, Shixiang Guo, Huaizhi Wang
Journal: Drug Resistance Updates (2023)
Ramifications of Precarious Employment for Health and Health Inequity: Emerging Trends from the Americas
Authors: Anjum Hajat, Sarah B. Andrea, Vanessa M. Oddo, Megan R. Winkler, Emily Q. Ahonen
Journal: Annual Review of Public Health (2023)

Precarious employment (PE), which encompasses the power relations between workers and employers, is a well-established social determinant of health that has strong ramifications for health and health inequity. In this review, we discuss advances in the measurement of this multidimensional construct and provide recommendations for overcoming continued measurement challenges. We then evaluate recent evidence of the negative health impacts of PE, with a focus on the burgeoning studies from North America and South America. We also establish the role of PE in maintaining and perpetuating health inequities and review potential policy solutions to help alleviate its health burden. Last, we discuss future research directions with a call for a better understanding of the heterogeneity within PE and for research that focuses both on upstream drivers that shape PE and its impacts on health, as well as on the mechanisms by which PE causes poor health.
A Soft Bioelectronic Patch for Simultaneous Respiratory and Cardiovascular Monitoring
Authors: Xue Wang, Xiao Xiao, Zhiping Feng, Yufen Wu, Jin Yang, Jun Chen
Journal: Advanced Healthcare Materials (2023)

Abstract Sleep is critical to maintaining physical and mental health. Measuring physiological parameters to quantify sleep quality without uncomfortable user experience remains highly desired but a challenge. Here, this work develops a soft bioelectronic patch to perform simultaneous respiration and cardiovascular monitoring during sleep in a wearable and non‐invasive manner. The soft bioelectronic patch system is mainly composed of a pressure sensor, a flexible printed circuit for signal processing, and a soft thermoplastic urethane mold for assembling different functional modules. The soft bioelectronic patch holds a sensitivity of &gt;0.12 V kPa −1 and a remarkable low‐frequency response from 0.5 to 15 Hz. It is demonstrated to continuously monitor respiration and heartbeat during the whole night, which could be harnessed for sleep monitoring and obstructive sleep apnea‐hypopnea syndrome diagnosis. The reported soft bioelectronic patch represents a simple and convenient platform technology for sleep study.
Asymmetric Triple‐Functional Janus Membrane for Blood Oxygenation
Authors: Zhenyi Zhao, Wenqing Gao, Yun Chang, Yue Yang, Hechen Shen, Tong Li, Song Zhao
Journal: Advanced Healthcare Materials (2023)

The oxygenation membrane, a core material of extracorporeal membrane oxygenation (ECMO), is facing challenges in balancing anti-plasma leakage, gas exchange efficiency, and hemocompatibility. Here, inspired by the asymmetric structural features of alveolus pulmonalis, a novel triple-functional membrane for blood oxygenation with a Janus architecture is proposed, which is composed of a hydrophobic polydimethylsiloxane (PDMS) layer to prevent plasma leakage, an ultrathin polyamide layer to enhance gas exchange efficiency with a CO