tbuckley/cabot-search huggingface dataset:
Graves?? Disease
Authors: JOHN A. VENTO, JAMES D. SLAVIN, GEORGE E. REARDON, RICHARD P. SPENCER
Journal: Clinical Nuclear Medicine (1986)

A 52-year-old man presented with left exophthalmos. A thyroid scan showed a right lobe hot nodule with suppression of the remainder of the gland. Thyroid function tests were normal. In less than two years, the patient had worsening of the exophthalmos. Thyroid indices then revealed hyperthyroidism and the thyroid image had markedly altered (with evidence of diffuse function). This change, initially showing a hot nodule and then diffuse thyroid overactivity, has been reported previously in three cases (all women). Characteristics of the disorder in these four individuals were reviewed. It is possible that the patients had two distinct diseases, separated temporally.
Inhibition of Differentiation and Proliferation of Colony-Stimulating Factor-Induced Clonal Growth of Normal Human Marrow Cells In Vitro by Retinoic Acid
Journal: JNCI Journal of the National Cancer Institute (1983)

Necessary for growth and differentiation in many normal tissues and capable of inducing differentiation in human promyelocytic cell lines, retinoids were the subject of this study. Specifically, effects of 13-cis-retinoic acid and 13-trans-retinoic acid on the growth of normal human bone marrow cells in a soft-agar system were studied. Both short-term incubation and continuous exposure to retinoic acid caused a decreased number of granulocyte colonies and an increased clusterto- colony ratio. This effect was concentration-dependent. Examination of specimens stained with Wright-Giemsa or nitro blue tetrazolium stains showed a progressive increase in the percentage of immature granulocytic precursors with increasing concentrations of retinoic acid. No effect of retinoic acid was seen on a number of human tumor cell lines. Retinoic acid blocked both differentiation and proliferation and appeared to do so by specific, noncytotoxic mechanisms in normal human bone marrow cells.
Deterministic-chaotic and periodic properties of heart rate and arterial pressure fluctuations and their mediation in piglets
Authors: U. Zwiener, D. Hoyer, R. Bauer, B. Luthke, B. Walter, K. Schmidt, S. Hallmeyer, B. Kratzsch, M. Eiselt
Journal: Cardiovascular Research (1996)

Objective: Only the simultaneous analysis of periodic and nonlinear properties of heart rate fluctuations (HRF) can describe completely this complex physiological process. Up to now there is, apart from a study of our own, no systematic and correlative investigation using both parameter groups, also not in early development. Thus, we tried to describe in this manner these properties of HRF, the corresponding mean arterial pressure fluctuations (MAPF) and respiratory movements (RM) and their mutual relations in neonatal pig. Methods: In 6 term newborn piglets, periodic properties of HRF, RM, and MAPF were analyzed by spectral and coherence analysis, and deterministic-chaotic properties by calculation of correlation dimension (CD), Lyapunov exponent (LE), and construction of phase space plots. The assumption of deterministic chaotic components was supported by Theiler's test for nonlinearity, by always positive leading LEs, and by the results of a nonlinear deterministic model. These analyses were done in sleep states, general anaesthesia, hypoxic hypoxia, in ventilated state, and during cholinergic and additional β-adrenergic blockade. Results: In all experimental states, HRF and MAPF have periodic and nonlinear, very probably deterministic-chaotic properties, but in different relations. In anaesthetized piglets, periodic properties of HRF and MAPF dominate. In hypoxia the decreasing LE and CD of HRF and CD of MAPF were connected with increasing MAPF power density. Cholinergic blockade caused a decreased overall HRF and MAPF power and a decreasing LE and CD, but β-adrenergic blockade decreased a small part of power density of both in 0.02–0.08 Hz only. The results of CD, LE, Theiler's test and the low dimensional deterministic model data suggested mainly deterministic-chaotic properties in the nonlinear part of HRF and MAPF. Conclusions: Already in neonatal piglets, both periodic and nonlinear, very probably deterministic chaotic properties of HRF and MAPF exist which change both during hypoxia and cholinergic blockade. They are partly cholinergically and — to a small extent — also β-adrenergically mediated. The decrease of nonlinear complexity of HRF and MAPF during hypoxia suggests characteristic pathological change even in early development.
A Text-Book of Psychology for Nurses.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights of This Issue
Journal: Clinical Cancer Research (2015)

Exploratory gene expression array analyses by Laszlo and colleagues suggested that multimerin-1 (MMRN1) could be a novel predictive biomarker in acute myeloid leukemia (AML). To follow up on these findings, MMRN1 expression was studied in two recent Children's Oncology Group trials. Although associated with some adverse disease-risk features, high MMRN1 expression was independently associated with shorter overall- and event-free survival as well as a higher relapse risk. These data identify MMRN1 expression as a novel biomarker that may refine AML risk-stratification.Selective inhibitors of nuclear export system (NES) have been developed for cancer therapy, but the underlying mechanisms were not well understood. To clarify the mechanisms, Miyake and colleagues performed proteomic analyses and identified a previously unrecognized mechanism whereby inhibition of NES causes eukaryotic initiation factor 5A (eIF5A) accumulation in mitochondria and induces apoptosis; this effect is regulated by direct binding with insulin-like growth factor 2 mRNA binding protein (IGF2BP1). These data provide a new understanding of eIF5A regulation in response to inhibition of NES and provide a potent anticancer therapeutic strategy.FGFR-TACC gene fusions have emerged as frequent chromosomal translocations across different tumors. To explore their role as therapeutic targets, Di Stefano and colleagues designed a screen covering all FGFR-TACC variants. FGFR-TACC fusions cluster in IDH-wild type grade II-IV glioma, co-occur with CDK4/MDM2 amplification, are alternative to EGFR alterations, and are uniformly expressed in the positive tumors. Preclinical experiments with FGFR-TACC-positive glioma treated with a specific FGFR inhibitor show strong antitumor effects and treatment of two patients with recurrent glioblastoma result in clinical improvement and tumor shrinkage. These results validate the selection of FGFR inhibitors for the treatment of FGFR-TACC-positive cancer.Neuroblastoma is an often lethal embryonal tumor arising from sympathetic neuronal precursor cells. ALK mutations occur in 10% of all tumors, and clinical trials with ALK inhibitors are underway. Because tumors often become resistant to small molecule inhibitors, Lambertz and colleagues decided to unravel the signaling components downstream of ALK to identify additional targets for combination therapy. The authors identified RET regulated through the ALK-AKT-FOXO3a pathway and propose RET inhibition as a possible novel combination therapy. Furthermore, mutant ALK also installs a negative MAPK feedback loop that may have consequences for resistance to novel targeted treatments.
Warfarin and Topical Salicylates
Authors: Frederick Littleton
Journal: JAMA (1990)

<h3>To the Editor.—</h3> Two patients who were receiving maintenance warfarin therapy and who experienced marked prolongation of the prothrombin time by topical nonprescription medications are described. <h3>Report of Cases. —</h3> Case1.—An 85-year-old woman was admitted to the hospital with an acute pulmonary embolism. She had congestive heart failure and atrial fibrillation and received anticoagulation therapy with heparin followed by warfarin. After a 12-day hospitalization, she was discharged with a prothrombin time of 1.5 times the control value. She presented subsequently with vaginal bleeding, irregular tachycardia, and orthostatic hypotension. Ecchymoses were seen on the left cheek, the right flank, and the perineum and gross bleeding from the vagina was evident. The hemoglobin was 80 g/L; it had been 117 g/L 2 months previously. The prothrombin time was 55.0 seconds, with a control value of 12.4 seconds; it had been 18.5 seconds with a similar control value 1 week previously.
Pulmonary Edema and Coma From Perchloroethylene
Authors: Ramesh Patel
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Perchloroethylene, known as Perk, is used widely as a dry cleaning agent. Exposure to its fumes results in irritation of skin and mucous surfaces, depression of the central nervous system, and hepatic and renal damage.<sup>1</sup>Pulmonary edema and coma may occur.<sup>2</sup>We report the development following exposure to fumes in a laundry worker. <h3>Report of a Case.—</h3> A 21-year-old man was admitted to the hospital in coma and acute pulmonary edema. The pulse rate was 88 beats per minute, blood pressure was 88/20 mm Hg, temperature was 34.4 C (94 F), and respirations were 48 per minute. He was in deep coma. Bubbling rales were heard over the entire lung fields. Isoproterenol, 0.8 mg in a liter of 5% dextrose, was infused intravenously. The central venous pressure was 14 cm H<sub>2</sub>O. A bolus of 40 mg of furosemide, 250 mg of aminophylline, and
Fracture of Acetabulum With Dislocation of Hip and Sciatic Palsy
Authors: Otto E. Aufranc
Journal: JAMA (1967)

Dr. David Grainger: The patient is a 39-year-old female, physical education instructor whose automobile was involved in a head-on collision while returning from a weekend of skiing. She was unconscious for approximately three minutes but was oriented when she arrived at the local hospital. Her chief complaints were pain in her right hip, abdomen, and chest. Examination and x-ray films at the local hospital revealed the following injuries: (1) closed fracture of right acetabulum with posterior dislocation of right hip (Fig 1), (2) closed fracture of left fifth metacarpal, (3) fracture of left third rib, (4) laceration of right leg, (5) multiple contusions and abrasions, and (6) possible intraperitoneal injury. A Foley catheter was inserted into the bladder without difficulty, and the specimen obtained was within normal limits. The patient was observed closely for several hours while being given appropriate fluid replacement, and gradual stabilization of her vital signs occurred.
Unexpected beneficial effects of measles immunisation
Authors: C. Dalton
Journal: BMJ (2000)

# Measles vaccination may be marker for other health seeking behaviours {#article-title-2} EDITOR —The hypothesis presented by Shann in his editorial that measles immunisation provides non-specific immune stimulation sufficient to decrease mortality from other diseases is interesting.1 However, I don't really believe that the studies have ruled out the more likely explanation that measles immunisation is just a marker for other socioculturally determined health seeking behaviours. The fact that similar effects are not seen for other vaccines does not exclude measles immunisation from being correlated with health seeking behaviours. Measles vaccination is different from other vaccinations in its timing, and it is often associated with national campaigns (including in some of the studies Shann references). Are there any data that rule out the confounding effect of sociocultural determinants? 1. 1.↵1. Shann F . A little bit of measles does you good. BMJ 1999; 319: 4–5. (3 July.) [OpenUrl][1][FREE Full Text][2] # Socioeconomic confounding may also play a part {#article-title-4} EDITOR—Shann in his editorial on measles1 discusses the hypothesis that standard dose Schwartz measles vaccine reduces mortality from conditions other than measles. He refers to the observation that measles causes only 10% of child mortality whereas the vaccine reduces mortality in developing countries by at least 30%2 and that immunised children who have not had measles have a much lower mortality than unimmunised children who have not had measles.2 3 When I worked at Murgwanza Hospital in Tanzania from 1984 to 1991 measles vaccination was generally available in the community through the maternal child health programmes. These programmes included an educational component relating to nutrition, prevention of disease, and early treatment of febrile illnesses such as malaria. As the primary healthcare programme gained momentum after the Alma Ata declaration, which aimed for health for all by the year 2000, efforts to improve health awareness intensified. It was distressing that children were not all immunised and that outbreaks of measles still occurred. Often children with measles presented late and had signs of other illnesses. We always assumed that children who were … [1]: {openurl}?query=rft.jtitle%253DBMJ%26rft.stitle%253DBMJ%26rft.issn%253D0007-1447%26rft.aulast%253DShann%26rft.auinit1%253DF.%26rft.volume%253D319%26rft.issue%253D7201%26rft.spage%253D4%26rft.epage%253D5%26rft.atitle%253DA%2Blittle%2Bbit%2Bof%2Bmeasles%2Bdoes%2Byou%2Bgood%26rft_id%253Dinfo%253Apmid%252F10390432%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=FULL&journalCode=bmj&resid=319/7201/4&atom=%2Fbmj%2F320%2F7239%2F938.atom
One Medical World
Authors: George D. Lundberg
Journal: JAMA (1983)

At its century mark,<i>JAMA</i>has a weekly circulation of 322,000 copies in English to 132 countries and 121,000 copies with varying frequencies of publication in five other languages in six countries. This is our attempt to educate one medical world and constitutes a circulation more than double that of any other medical journal. The article on page 236 by Sammons and colleagues describes the history of the multilanguage publishing effort. It captures the adventure, emotion, and internationalism that all of us feel, especially when working with the non-English language editions. The basic way in which this publishing process works is as follows. After discussions with a national medical association and appropriate market testing, the American Medical Association develops a contract with a leading publishing firm in the respective country. All articles that appear in a non-English language edition must first have appeared in the English language<i>JAMA</i>, thus ensuring
Congenital Syphilis—United States, 2000
Journal: JAMA (2001)

Congenital syphilis (CS) occurs when the spirochete Treponema pallidum is transmitted from a pregnant woman with syphilis to her fetus. A multiorgan infection, CS may result in a neurologic or musculoskeletal handicap or death in the fetus when not properly treated. Trends in CS rates in women of childbearing age follow by approximately 1 year the rates of primary and secondary syphilis. The last national syphilis epidemic, which was followed by a CS epidemic, occurred during the late 1980s and early 1990s. The syphilis rate began to decline in 1991; the CS rate began to decline in 1992. To evaluate CS epidemiology since this decline, CDC analyzed 1998 CS notifiable disease data and assessed rate changes during 1992-1998. This report summarizes the results, which indicate that the CS rate declined 78.2% from 1992 to 1998, and that rates remained disproportionately high in the southeastern United States and among minority racial/ethnic populations.
Renovascular Hypertension and Double Renal Arterial Supply Diagnosed by Tc-99m MAG3 Captopril Renography
Authors: O. Morel, Gilles Metrard, Christian Jeanguillaume, H. Rakotonirina, T. Blaire, J.J. Lejeune, P. Jallet
Journal: Clinical Nuclear Medicine (2006)

Renovascular hypertension is the most frequent secondary cause of hypertension (0.5–2%). Captopril renal scintigraphy is safe, noninvasive, and effective in the detection of renovascular hypertension. Positive captopril renography may suggest a cure of hypertension and improvement in renal function with successful renal revascularization. The authors report the case of successful detection of renovascular hypertension by captopril renal scintigraphy in a patient with 2 hilar renal arteries. Revascularization of the stenosed hilar artery was obtained by transluminal angioplasty and stent placement, leading to rapid control of the hypertension.
EXPERT WITNESSES APPOINTED BY THE COURT.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Palpable Neck Mass and Multiple Bone Lesions
Authors: Philip M. Hatfield
Journal: JAMA (1971)

Dr. Jeffrey P. Rudnick: The patient is a 45-year-old physicist who had experienced malaise and generalized bone pain for about two years. Two days prior to admission, the patient noted severe pain in the left elbow while putting on his coat. On routine physical examination one year ago, a nodule, measuring 1.5 cm, was felt in the left lobe of his thyroid. Roentgenograms of the chest and long bones were obtained. <h3>Discussion</h3> Dr. Joseph Hanelin: There is a large lesion in the mid-ulna with adjacent soft-tissue swelling (Fig 1). I do not see a fracture. The edges of the area of destruction are not sharp, at least proximally, and the bone is quite thinned and expanded. Was he febrile? Dr. Rudnick: He did not have a fever. Dr. Hanelin: This is a destructive lesion, and in someone this age, one would think in terms of malignancy. Multiple myeloma is a
Medical Diagnosis. Special Diagnosis of Internal Medicine. A Handbook for Physicians and Students.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cross-Body Block, the Major Cause of Knee Injuries
Authors: Thomas R. Peterson
Journal: JAMA (1970)

A detailed study of 259 knee injuries incurred by football players at the University of Michigan and Michigan State University, and by Detroit Lions players points out the various causes of knee injuries occurring on the football field. The study indicts the cross-body block as the major cause of such injuries and describes the blocking method in terms of its place in the game. Although many coaches and officials have been aware of the hazards of the cross-body block, legislative recognition has been given only to its use in "clipping." There is danger of serious visceral injury to the blocker who uses this method. Disability due to knee injury as well as permanent degenerative changes secondary to these injuries make preventive measures desirable. Elimination of the cross-body block could significantly reduce serious knee injuries.
The Morbidity of Differential Renal Function Studies
Authors: Douglas S. Dahl
Journal: JAMA (1967)

Differential renal function studies were performed according to the Stamey technique on 271 patients in a five-year period. The complications were assigned one of three grades. Subjective complaints of less than 24 hours' duration, grade 1, occurred in 21%. Grade 2 complications, subjective complaints of over 24 hours' duration, occurred in 18%. Grade 3 complications which included urinary tract infection, vesical hemorrhage, oliguria, cardiac decompensation, and myocardial infarction occurred in 13 patients, or 5%. There was no significant difference in the rate of complications in relation to size of catheter, anesthesia, the concentration of urea, or the final diagnosis. Fewer complications were associated with the use of flexible polyethylene ureteral catheters than with the other types. Despite the complications, differential renal function studies provide informaton of critical importance in the diagnostic and prognostic evaluation of patients with renovascular hypertension.