Integral effects of xenon: Inhibition of postovariectomy syndrome development in young women with cervical and breast cancers.
Authors: Natalia N. Popova, Alla I. Shikhlyarova, Elena M. Frantsiyants, Larisa N. Vashchenko, Emma E. Kechedzhieva, Stella M. Babieva, Irina V. Kaplieva, Irina V. Neskubina, Natalia D. Cheryarina, Lidia K. Trepitaki, Yuriy V. Przhedetskiy, Viktoria V. Pozdnyakova, Ekaterina V. Verenikina, Anna P. Menshenina, Ekaterina I. Surikova, Valeria A. Bandovkina, Dmitry A. Rozenko, Sergey V. Tumanyan, Oleg I. Kit
Journal: Journal of Clinical Oncology (2022)

e17515 Background: The development of deep postovariectomy disorders in young women with cervical and breast cancers is of extreme concern. They are associated with the suppression of the hypothalamic-pituitary-gonadal axis of regulation, estrogen involution, a sharp depression of the psycho-emotional state, and social distancing. In fact, these postovariectomy syndrome (POES) events are associated with low-reactivity stress syndrome. Our purpose included the transition of dominant stress into archetypes of anti-stress adaptive reactions under the influence of programmable exponential dose regimens of xenon-oxygen therapy (XOT) in the early period after the removal of the female reproductive organs. Methods: 123 patients of reproductive age diagnosed with cervical cancer pT 1 B 2 N 0 M 0 and 24 patients with hormone-positive breast cancer pT 2 N 1 M 0 and concomitant gynecological pathology underwent hysterectomy with oophorectomy and developed POES. All patients received a cycle (5 procedures) of low-dose inhalation XOT. The therapy consisted in a gradual increase in the percentage of xenon in the inhaled xenon-oxygen mixture with a reciprocal decrease in exposure time, an exponential regimen in the concentration range from 12–14% to 20–24% and exposure from 25 to 10 minutes. Blood levels of FSH, LH, estradiol, progesterone, and testosterone were measured by RIA (Immunotech, Czech Republic) before and after XOT. The psycho-emotional status was assessed by the generally accepted quality of life scales for cancer patients MOS-SF-36 and ESAS, the type of adaptive reactions was identified by Garkavi using the analysis of Schilling's leukogram, the severity of POES was determined by the menopausal index (MMI). Results: The POES manifestation and the dominance of acute stress were due to the inversion of hormonal metabolism - a decrease in the level of estradiol 487.3±52.4 and progesterone 1.8±0.1 relative to the initial levels 1017.9±83.4 nmol/L and 11.8±0.7 nmol/L, respectively, with an increase in FSH by 5.8 times, and LH by 2.4 times (p &lt; 0.05). An accompanying XOT resulted in a significant MMI decrease (p &lt; 0.05), training and calm activation reactions prevailed in 80% cases with harmonious changes in the regulation of hormonal processes and a clear regression of the acute estrogen deficiency (elevation of estradiol levels to 751.4±61.4 nmol/L and a decrease in FSH and LH by 1.5 and 2.1 times, respectively (p &lt; 0.05)). MOS-SF-36 and ESAS assessment showed a significant decrease in pathological symptoms. Conclusions: XOT in the early postoperative period in cancer patients of the reproductive age with POES normalized their hormonal status, corrected functional disorders and improved their quality of life.