tbuckley/cabot-search huggingface dataset:
A safe therapeutic strategy for giant pedunculated colorectal polyps with thick stalks
Authors: Takehide Fukuchi, Shigeru Iwase, Shinpei Kondo, Shin Maeda
Journal: Endoscopy (2023)

Endoscopic resection of giant pedunculated colorectal polyps (PCPs) with large heads and thick stalks can be technically difficult with conventional snare polypectomy and involves the risk of clinically significant bleeding [1]. The European Society of Gastrointestinal Endoscopy guideline recommends pretreatment of the stalk with a dilute epinephrine injection and mechanical hemostasis (prophylactic clip and endoloop application) for PCPs [2] [3]. Endoscopic submucosal dissection (ESD) can control hemostasis [1] [4] [5]. However, some cases comprising large tumor heads are associated with challenging operability and poor visibility, so achieving hemostasis can be difficult. We have developed a strategy to manage bleeding during colorectal ESD of PCPs with thick stalks ([Video 1]).
Allelic Context of EGFR C797X–Mutant Lung Cancer Defines Four Subtypes With Heterogeneous Genomic Landscape and Distinct Clinical Outcomes
Authors: Chang Lu, Xue-Wu Wei, Zhen Wang, Zhen Zhou, Yu-Tao Liu, Di Zheng, Yong He, Zhan-Hong Xie, Yong Li, Yan Zhang, Yi-Chen Zhang, Zi-Jian Huang, Shi-Qi Mei, Jia-Qi Liu, Xu-Hui Guan, Yu Deng, Zhi-Hong Chen, Hai-Yan Tu, Chong-Rui Xu, Hua-Jun Chen, Wen-Zhao Zhong, Jin-Ji Yang, Xu-Chao Zhang, Tony S K Mok, Yi-Long Wu, Qing Zhou
Journal: Journal of Thoracic Oncology (2023)

EGFR C797X (C797S or C797G) mutation is the most frequent on-target mechanism of resistance to osimertinib. The hypothesis that the allelic context of C797X/T790M has implications for treatment is on the basis of sporadic reports and needs validation with larger cohorts.
Abatacept in early polymyalgia rheumatica (ALORS): a proof-of-concept, randomised, placebo-controlled, parallel-group trial
Authors: Alain Saraux, Catherine Le Henaff, Emmanuelle Dernis, Guillermo Carvajal-Alegria, Alice Tison, Baptiste Quere, Hélène Petit, Renaud Felten, Sandrine Jousse-Joulin, Dewi Guellec, Thierry Marhadour, Patrice Kervarrec, Divi Cornec, Solene Querellou, Emmanuel Nowak, Aghiles Souki, Valérie Devauchelle-Pensec
Journal: The Lancet Rheumatology (2023)
Recurrent obstruction after surgical gastrojejunostomy in a rare case of gastric outlet obstruction: endoscopic ultrasound-guided gastrojejunostomy to the rescue
Authors: Jayanta Samanta, Jahnvi Dhar, Jayendra Shukla, Anurag Sachan, Aravind Sekar, Pankaj Gupta, Antonio Facciorusso
Journal: Endoscopy (2023)

A 49-year-old man with alcohol-related chronic calcific pancreatitis presented with abdominal pain, vomiting, and weight loss (12 kgs) for 5 months. He had undergone truncal vagotomy with antecolic gastrojejunostomy 3 years previously for peptic ulcer disease with gastric outlet obstruction (GOO). After initially improving, he again became symptomatic with intermittent symptom-free intervals on proton pump inhibitors.
REM parameters in drug-free major depressive disorder: A systematic review and meta-analysis
Authors: Mehmet K. Arıkan, Ömer Uysal, Şakir Gıca, Özden Orhan, Reyhan İlhan, Muhammed T. Esmeray, Hasan Bakay, Barış Metin, Oliver Pogarell, Şenol Turan
Journal: Sleep Medicine Reviews (2023)
Identification of a novel HIV-1 circulating recombinant form CRF157_A6C in Primorsky Territory, Russia
Authors: Maksim R. Halikov, Vasily E. Ekushov, Alexei V. Totmenin, Natalya M. Gashnikova, Mariya E. Antonets, Tatyana V. Tregubchak, Lidiia P. Skliar, Natalia P. Solovyova, Irina S. Gorelova, Svetlana N. Beniova
Journal: Journal of Infection (2023)

Dear editor,
Surgical suture-assisted endoscopic band ligation for the management of recurrent hemostasis after unsuccessful use of hemoclips for diverticular bleeding
Authors: Shaoxiong Zeng, Qu Zhang, Qin Li, Qingtian Luo, Minwen Jiang, Chun-sheng Cheng
Journal: Endoscopy (2023)

A 47-year-old obese man presented with acute-onset lower abdominal pain and hematochezia of unknown etiology, accompanied by dizziness and fatigue. His stool was characterized as dark red and watery, and of significant volume. The patient underwent an emergency colonoscopy, during which intermittent hemorrhage was observed at the site of a transverse colon diverticulum ([Fig. 1] a). Three hemostatic clips were successfully placed to occlude the diverticulum during the endoscopic procedure, and bleeding was observed to have ceased.
Underwater endoscopic submucosal dissection with dental floss traction for the treatment of early pharyngeal cancer
Authors: Silin Huang, Li Tan, Suhuan Liao, Haining Cai, Guang Yang, Jianzhen Ren, Kajie He
Journal: Endoscopy (2023)

A 72-year-old man underwent a gastroscopy that revealed a 13 × 11-mm lesion within the left pyriform sinus (0-IIb). The lesion displayed a reddish hue under white light, with well-defined borders ([Fig. 1]a). Its tea-colored appearance under blue-laser imaging (BLI) classified it as type B1, indicative of an early pharyngeal tumor ([Fig. 1]b).
Innovations for colonic endoscopic submucosal dissection: combination of the latest game changers
Authors: Mathieu Pioche, Louis Jean Masgnaux, Romain Legros, Timothée Wallenhorst, Jérémie Albouys, Jérôme Rivory, Jeremie Jacques
Journal: Endoscopy (2023)

Endoscopic submucosal dissection (ESD) in 2023 is nothing like it was originally in 2001, with major changes in equipment and strategies. However, the spread of ESD has been slow because it is a challenging procedure, and major new developments are expected to simplify it further.
Duodenal metal stent deployment using a novel, cholangioscope-guided, guidewire insertion technique
Authors: Takeshi Ogura, Junichi Nakamura, Jun Sakamoto, Yuki Uba, Hiroki Nishikawa
Journal: Endoscopy (2023)

Malignant gastric outlet obstruction (GOO) occurs with advanced or metastatic malignancies located in the duodenum and is present in up to 19% of patients with unresectable malignant tumors [1]. Duodenal obstruction can be traditionally treated by gastrojejunostomy, but endoscopic duodenal stenting has been suggested as a less invasive treatment [2]. More recently, endoscopic ultrasound-guided gastroenterostomy using lumen-apposing metal stents has been reported [3] [4]. However, as this technique may need to be performed by experts or in high-volume centers, endoscopic duodenal stenting is still an important procedure. During duodenal stenting, guidewire passage through the stricture to the anal side is needed, but this technique is sometimes challenging. Recently, a novel cholangioscope (eyeMAX; Micro-Tech Co., Ltd., Nanjing, China), which offers improved visibility, has become available. This report describes guidewire deployment using this novel cholangioscope for guidance in duodenal stent deployment in a case of duodenal obstruction.
Double-scope technique to recover from hand-suturing trouble in the duodenum
Authors: Leonardo Yoshio Sato, Yoshitaka Hata, Mitsuru Esaki, Eikichi Ihara, Shiho Tajiri, Tomohiko Moriyama, Yosuke Minoda
Journal: Endoscopy (2023)

Duodenal adenomas are uncommon, with a prevalence of 0.3%–4.6% [1] [2]. Endoscopic resection (ER) is the standard treatment for a solitary adenoma. As ER for duodenal lesions is associated with a high risk of adverse events, such as bleeding and delayed perforation, closure of post-ER ulcers has been reported as being effective in reducing the risk of complications [3] [4] [5].
Diagnosis of a giant gastric subepithelial lesion using a dual-frequency ultrasonic miniprobe
Authors: Suhuan Liao, Weiguang Qiao, Silin Huang, Guang Yang, Ronggang Zhang, Weiwen Wu, Xiaosong Bai
Journal: Endoscopy (2023)

A 43-year-old woman was referred for endoscopic resection after detection of a giant subepithelial lesion (SEL) during routine physical assessment. The lesion was approximately 50 × 25 mm in size and was located in the posterior wall of the gastric fundus ([Fig. 1]). A comprehensive assessment of the origin and characteristics of the lesion was performed via a dual-frequency ultrasonic miniprobe (InnerMedical Co., Ltd., Shenzhen, China) ([Fig. 2], [Video 1]).
Determinants of Progression and Regression of Subclinical Atherosclerosis Over 6 Years
Authors: Guiomar Mendieta, Stuart Pocock, Virginia Mass, Andrea Moreno, Ruth Owen, Inés García-Lunar, Beatriz López-Melgar, Jose J. Fuster, Vicente Andres, Cristina Pérez-Herreras, Hector Bueno, Antonio Fernández-Ortiz, Javier Sanchez-Gonzalez, Ana García-Alvarez, Borja Ibáñez, Valentin Fuster
Journal: Journal of the American College of Cardiology (2023)

Atherosclerosis is a systemic disease that frequently begins early in life. However, knowledge about the temporal disease dynamics (ie, progression or regression) of human subclinical atherosclerosis and their determinants is scarce. This study sought to investigate early subclinical atherosclerosis disease dynamics within a cohort of middle-aged, asymptomatic individuals by using multiterritorial 3-dimensional vascular ultrasound (3DVUS) imaging. A total of 3,471 participants from the PESA (Progression of Early Subclinical Atherosclerosis) cohort study (baseline age 40-55 years; 36% female) underwent 3 serial 3DVUS imaging assessments of peripheral arteries at 3-year intervals. Subclinical atherosclerosis was quantified as global plaque volume (mm3) (bilateral carotid and femoral plaque burden). Multivariable logistic regression models for progression and regression were developed using stepwise forward variable selection. Baseline to 6-year subclinical atherosclerosis progression occurred in 32.7% of the cohort (17.5% presenting with incident disease and 15.2% progressing from prevalent disease at enrollment). Regression was observed in 8.0% of those patients with baseline disease. The effects of higher low-density lipoprotein cholesterol (LDL-C) and elevated systolic blood pressure (SBP) on 6-year subclinical atherosclerosis progression risk were more pronounced among participants in the youngest age stratum (Pinteraction = 0.04 and 0.02, respectively). Over 6 years, subclinical atherosclerosis progressed in one-third of middle-age asymptomatic subjects. Atherosclerosis regression is possible in early stages of the disease. The impact of LDL-C and SBP on subclinical atherosclerosis progression was more pronounced in younger participants, a finding suggesting that the prevention of atherosclerosis and its progression could be enhanced by tighter risk factor control at younger ages, with a likely long-term impact on reducing the risk of clinical events. (Progression of Early Subclinical Atherosclerosis [PESA; also PESA-CNIC-Santander]; NCT01410318)
Primary Prevention of Subclinical Atherosclerosis in Young Adults
Authors: Ana Devesa, Borja Ibanez, Waqas A. Malick, Elizabeth O. Tinuoye, Jessica Bustamante, Carlos Peyra, Robert S. Rosenson, Deepak L. Bhatt, Gregg W. Stone, Valentin Fuster
Journal: Journal of the American College of Cardiology (2023)
Snare-tipped endoscopic radical incision and cutting for postoperative colorectal anastomotic stricture
Authors: Chung-Ying Lee, Tung-Cheng Chang, Ming-Yao Chen
Journal: Endoscopy (2023)

Postoperative colorectal anastomotic strictures are not uncommon and often require endoscopic or surgical intervention [1]. Initial treatment typically involves endoscopic balloon dilation, which may need to be repeated for long-term efficacy [2] [3]. Endoscopic radical incision and cutting has emerged as a novel technique for the treatment of refractory strictures. This technique enables the direct removal of fibrotic scar tissue, reducing the risk of restenosis [2] [4] [5]. Herein, we introduce a safe and cost-effective method of performing radical incision and cutting using a snare tip to treat benign anastomotic strictures.
Humoral and cellular immune responses following BNT162b2 XBB.1.5 vaccination
Authors: Metodi V Stankov, Markus Hoffmann, Rodrigo Gutierrez Jauregui, Anne Cossmann, Gema Morillas Ramos, Theresa Graalmann, Emily Jo Winter, Michaela Friedrichsen, Inga Ravens, Tamara Ilievska, Jasmin Ristenpart, Anja Schimrock, Stefanie Willenzon, Gerrit Ahrenstorf, Torsten Witte, Reinhold Förster, Amy Kempf, Stefan Pöhlmann, Swantje I Hammerschmidt, Alexandra Dopfer-Jablonka, Georg M N Behrens
Journal: The Lancet Infectious Diseases (2023)
Pathways to a healthy net-zero future: report of the Lancet Pathfinder Commission
Authors: Sarah Whitmee, Rosemary Green, Kristine Belesova, Syreen Hassan, Soledad Cuevas, Peninah Murage, Roberto Picetti, Romain Clercq-Roques, Kris Murray, Jane Falconer, Blanca Anton, Tamzin Reynolds, Hugh Sharma Waddington, Robert C Hughes, Joseph Spadaro, Aimée Aguilar Jaber, Yamina Saheb, Diarmid Campbell-Lendrum, Maria Cortés-Puch, Kristie Ebi, Rachel Huxley, Mariana Mazzucato, Tolu Oni, Nicole de Paula, Gong Peng, Aromar Revi, Johan Rockström, Leena Srivastava, Lorraine Whitmarsh, Robert Zougmoré, Joy Phumaphi, Helen Clark, Andy Haines
Journal: The Lancet (2023)
Annals Consult Guys - Postoperative Troponin Elevation
Authors: Howard H. Weitz, Geno J. Merli
Journal: Annals of Internal Medicine (2023)

Web ExclusivesNovember 2023Annals Consult Guys - Postoperative Troponin ElevationFREEHoward H. Weitz, MD, and Geno J. Merli, MDHoward H. Weitz, MDThomas Jefferson University, Philadelphia, Pennsylvania (H.H.W., G.J.M.)Search for more papers by this author, and Geno J. Merli, MDThomas Jefferson University, Philadelphia, Pennsylvania (H.H.W., G.J.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W22-0024 CME/MOC SectionsSupplemental MaterialAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The Annals Consult Guys provide guidance about the measurement and interpretation of high-sensitivity cardiac troponin in the setting of noncardiac surgery.For more videos from and information on Annals Consult Guys, visit go.annals.org/ConsultGuys. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAuthors: Howard H. Weitz, MD; Geno J. Merli, MDAffiliations: Thomas Jefferson University, Philadelphia, Pennsylvania (H.H.W., G.J.M.)Disclosures: Drs. Merli and Weitz report that they have no financial relationships or interests to disclose. All relevant financial relationships have been mitigated. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=W22-0024.Editors' Disclosures: The editors have no relevant financial relationships to disclose. Individual forms may be viewed at www.annals.org/editorsdisclosures. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Current IssueNovember 2023Volume 176, Issue 11 ePublished: 21 November 2023 Issue Published: November 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.Loading ...
Dear
Authors: Sarah Marion
Journal: Annals of Internal Medicine (2023)

Ad LibitumNovember 2023DearSarah Marion, BASarah Marion, BAUniversity of Virginia School of Medicine, Charlottesville, VirginiaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M23-1136 Audio Reading - “Dear” Supplement. Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Dear” by Sarah Marion, BA Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail who lived in a ... Author, Article, and Disclosure InformationAuthors: Sarah Marion, BAAffiliations: University of Virginia School of Medicine, Charlottesville, VirginiaCorresponding Author: Sarah Marion, BA; e-mail, swm5tx@virginia.edu. PreviousarticleNextarticle Advertisement Audio Reading - “Dear” Supplement. Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Dear” by Sarah Marion, BA Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics Current IssueNovember 2023Volume 176, Issue 11Page: 1563 ePublished: 21 November 2023 Issue Published: November 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Nullius in Verba
Authors: Daniel Bosch
Journal: Annals of Internal Medicine (2023)

Ad LibitumNovember 2023Nullius in VerbaDaniel BoschDaniel BoschAtlanta, GeorgiaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M23-1733 Audio Reading - “Nullius in Verba” Supplement. Audio. Virginia L. Hood, MD, a physician from the University of Vermont, reads “Nullius in Verba” by Daniel Bosch Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail —Motto of the Royal SocietyWhen she was a child She was misled aboutWhen she was a child.She weighed just over three stone. The first time her father was on top of herShe weighed just over three stone.The slats of a twin bed can flex. This is not a question of language.The slats of a twin bed can flex.Every clock’s face seemed to say The same thingEvery clock’s face seemed to say.The twist always came Just after. AndThe twist always came.What’s worse Is that she came to knowWhat’s worse.We had nothing ... Author, Article, and Disclosure InformationAuthors: Daniel BoschAffiliations: Atlanta, GeorgiaCorresponding Author: Daniel Bosch; e-mail, danielhbosch@gmail.com. PreviousarticleNextarticle Advertisement Audio Reading - “Nullius in Verba” Supplement. Audio. Virginia L. Hood, MD, a physician from the University of Vermont, reads “Nullius in Verba” by Daniel Bosch Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics Current IssueNovember 2023Volume 176, Issue 11Page: 1566 ePublished: 21 November 2023 Issue Published: November 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Annals On Call - Protecting Adults Against Respiratory Syncytial Virus Infection
Authors: Robert M. Centor, Camille Nelson Kotton
Journal: Annals of Internal Medicine (2023)

Web ExclusivesNovember 2023Annals On Call - Protecting Adults Against Respiratory Syncytial Virus InfectionFREERobert M. Centor, MD, and Camille Nelson Kotton, MDRobert M. Centor, MDHuntsville Regional Medical Campus, University of Alabama Birmingham School of Medicine, Birmingham, Alabama (R.M.C.)Search for more papers by this author, and Camille Nelson Kotton, MDTransplant and Immunocompromised Host Infectious Diseases Group, Infectious Diseases Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (C.N.K.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/A22-0022 CME/MOC SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In this episode of Annals On Call, Dr. Centor discusses respiratory syncytial virus infection in adults and recently approved respiratory syncytial virus vaccines with Dr. Camille Kotton.Annals articles discussed include...More Protection Against Respiratory Viral Infection: Respiratory Syncytial Virus Vaccines for Adults Aged 60 Years and Older: https://www.acpjournals.org/doi/10.7326/M23-2196About Annals On CallAnnals On Call focuses on a clinically influential article published in Annals of Internal Medicine. Dr. Robert Centor shares his own perspective on the material and interviews topic area experts to discuss, debate, and share diverse insights about patient care and health care delivery.For more information on Annals On Call and for more episodes, visit go.annals.org/OnCall. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAuthors: Robert M. Centor, MD; Camille Nelson Kotton, MDAffiliations: Huntsville Regional Medical Campus, University of Alabama Birmingham School of Medicine, Birmingham, Alabama (R.M.C.)Transplant and Immunocompromised Host Infectious Diseases Group, Infectious Diseases Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (C.N.K.)Disclosures: All relevant financial relationships have been mitigated. Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=A22-0022.Editors' Disclosures: The editors have no relevant financial relationships to disclose. Individual forms may be viewed at www.annals.org/editorsdisclosures. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMore Protection Against Respiratory Viral Infection: Respiratory Syncytial Virus Vaccines for Adults Aged 60 Years and Older Camille Nelson Kotton Metrics Current IssueNovember 2023Volume 176, Issue 11 ePublished: 21 November 2023 Issue Published: November 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.Loading ...