AB1018 RELATIONSHIP BETWEEN AORTIC CALCIFICATIONS AND DXA AND RADIOFREQUENCY ECHOGRAPHIC MULTI-SPECTROMETRY (REMS) ACQUISITIONS
Authors: A. Fassio, S. Andreola, D. Gatti, M. Gatti, G. Gambaro, O. Viapiana, V. Messina, G. Zanetti, F. Pistillo, M. Rossini, G. Adami
Journal: Annals of the Rheumatic Diseases (2022)

Background Data on the relationship between peritoneal dialysis (PD), BMD and aortic calcifications (AOC) are lacking. Objectives to study the relationship between the degree of AOC and DXA and Radiofrequency Echographic Multi-Spectrometry (REMS) acquisitions. Methods Consecutive patients referring to the PD our clinic were enrolled. Lumbar spine (LS) and proximal femur REMS scans were performed, and LS (anteroposterior and laterolateral) and proximal femur DXA scans were performed as well. The degree of AOC was assessed through the semiquantitative score described by Kauppila et al, and applied to the laterolateral LS DXA scans. To test for correlations between different variables, we used the Pearson’s correlation for continuous variables and Spearman’s rho for discrete variables. Multiple regression analysis was performed to adjust for age and body mass index (BMI) the correlation between BMD and the CKD duration. Written informed consent was obtained from all participants (protocol 1483CESC). Results 41 total patients were enrolled (29 males, 19 females). Median disease duration of CKD [IQR]: 132 months [48-140]. 15% had vertebral fractures at the DXA Vertebral Fracture Assessment (VFA). The median calcification score [IQR] was 2 [0-6] (min-max 0-20). We found a statistically significant positive correlation of moderate strength between the total calcification score and the difference between the DXA AP T-score and the DXA LL T-score at the LS (p&lt;0.01, Spearman’s rho = 0.402), Figure 1. Figure 1. scatter plot reporting the relationship between the difference between the AP and LL T-scores and the aortic calcifications score. After adjustment for confounders, we found a significant negative between the LS and femoral neck BMD measured through REMS and CKD duration (Table 1). The same correlation was not significant then BMD was assessed with DXA. Table 1. multiple linear regression analysis for REMS T-score at each site after adjustment for age and BMI. BMI, body mass index; β, standardised coefficient. REMS lumbar spine T-score β p CKD duration (months) -0.228 0.035 Age (years) -0.511 &lt;0.01 BMI (kg/m2) 0.566 &lt;0.01 REMS femoral neck T-score β p CKD duration (months) -0.210 0.04 Age (years) -0.612 &lt;0.01 BMI (kg/m2) 0.484 &lt;0.01 REMS total hip T-score β p CKD duration (months) -0.153 0.219 Age (years) -0.523 &lt;0.01 BMI (kg/m2) 0.560 &lt;0.01 Conclusion Our study confirmed that the overestimation of DXA BMD assessed with the anteroposterior scan is indeed influenced by AOC. Furthermore, our data suggest that REMS might be an interesting tool for the investigation of bone changes in CKD. Disclosure of Interests Angelo Fassio: None declared, Stefano Andreola: None declared, Davide Gatti Speakers bureau: Amgen, Celgene Eli-Lilly, MSD-Italia, Organon, UCB, Paid instructor for: Amgen, Celgene Eli-Lilly, MSD-Italia, Organon, UCB, Matteo Gatti: None declared, Giovanni Gambaro Speakers bureau: Vitor Pharma, Ombretta Viapiana: None declared, Valeri Messina: None declared, Giulia Zanetti: None declared, Francesca Pistillo: None declared, Maurizio Rossini Speakers bureau: Abiogen, Amgen, Abbvie, BMS, Celgene, Eli-Lilly, Galapagos, Grunenthal, MSD, Novartis, Pfizer, Sanofi, Sandoz, Theramex, UCB., Giovanni Adami: None declared