tbuckley/cabot-search huggingface dataset:
Efficacy and safety of 13 surgical techniques for the treatment of complex anal fistula, non-Crohn CAF: a systematic review and network meta-analysis
Authors: Yongkang An, Jihua Gao, Jiancheng Xu, Wenyue Qi, Linyue Wang, Maosheng Tian
Journal: International Journal of Surgery (2023)

Background: Considering the difficulty of treating complex anal fistula (CAF), various surgical techniques exist in clinical work. However, none are ideal. Evidence on the efficacy and safety of different surgical treatments is scarce. We aimed to compare the outcomes of the 13 surgical techniques and tried to find the best surgical method for treating CAF. Materials and Methods: We searched worldwide databases, including Pubmed, Embase, Cochrane Library, Web of Science, CNKI, WanFang, VIP, and SinoMed, from inception to March 2023. All randomized controlled trials (RCTs) comparing the outcomes of 13 surgical techniques were included according to the PICO principles. The indicators of the cure rate, the recurrence rate, the complication rate, the operating time, the postoperative pain on day 1 (VAS), and the postoperative incontinence in month 1 (Wexner) were extracted and analyzed using STATA software 15.1, Review Manager 5.4, and GeMTC14.3. Results: Twenty-eight RCTS with a total of 2274 patients were included in the network meta-analysis. There was no statistically significant difference in the comparison among any surgical interventions in terms of the cure rate ( P &gt;0.05 Table 2) and recurrence rate ( P &gt;0.05 Table 3). However, in terms of complication rate, fistulectomy was lower than FPS (Median: 0.14; 95% CI: 0.02, 0.70) or fistulotomy (Median: 0.09; 95% CI: 0.01, 0.55), and fistulotomy was lower than EAFR (Median: 0.24; 95% CI: 0.05, 0.84), LIFT (Median: 0.17; 95% CI: 0.02, 0.66) or LIFT-EAFR(Median: 0.11; 95% CI: 0.01, 0.69) ( P &gt;0.05 Table 4). The surface estimated the advantages and disadvantages under the cumulative ranking (SUCRA). The ranking results indicated that fistulectomy might have the lowest complication rate (SUCRA=7.9%). Because the network results of the operating time, the postoperative pain, and the postoperative incontinence contained no closed loops, the results of their probability ranking could only be referenced, demonstrating that fistulectomy might have the shortest operating time (SUCRA=23.4%), VAMLIFT might have the lowest postoperative pain on day 1 (VAS) (SUCRA=0.4%) and LIFT might have the lowest postoperative incontinence in month 1(Wexner) (SUCRA=16.2%). Conclusion: Fistulectomy might have the lowest complication rate, which might be the relatively superior surgical technique for treating CAF.
Prevalence and associated factors of vitamin D deficiency after Roux-en-Y gastric bypass: a systematic review and meta-analysis
Authors: Zhiguang Gao, Yuzhi Liang, Shifang Huang, Zhenpeng Wu, Min Li, Jingge Yang
Journal: International Journal of Surgery (2023)

To estimate the prevalence and associated factors of vitamin D deficiency (VDD) after Roux-en-Y gastric bypass (RYGB).
Photo‐Cross‐Linkable, Injectable, and Highly Adhesive GelMA‐Glycol Chitosan Hydrogels for Cartilage Repair
Authors: Sattwikesh Paul, Karsten Schrobback, Phong Anh Tran, Christoph Meinert, Jordan William Davern, Angus Weekes, Travis Jacob Klein
Journal: Advanced Healthcare Materials (2023)

Hydrogels provide a promising platform for cartilage repair and regeneration. Although hydrogels have shown some efficacy, they still have shortcomings including poor mechanical properties and suboptimal integration with surrounding cartilage. Herein, hydrogels that are injectable, cytocompatible, mechanically robust, and highly adhesive to cartilage are developed. This approach uses GelMA-glycol chitosan (GelMA-GC) that is crosslinkable with visible light and photoinitiators (lithium acylphosphinate and tris (2,2'-bipyridyl) dichlororuthenium (II) hexahydrate ([RuII(bpy)
Peer Review and Scientific Publication at a Crossroads
Authors: John P. A. Ioannidis, Michael Berkwits, Annette Flanagin, Theodora Bloom
Journal: JAMA (2023)

The way science is assessed, published, and disseminated has markedly changed since 1986, when the launch of a new Congress focused on the science of peer review was first announced.There have been 9 International Peer Review Congresses since 1989, typically running on an every-4-year cycle, and most recently in 2022 after a 1-year delay due to the COVID-19 pandemic. 1Here, we announce that the 10th International Congress on Peer Review and Scientific Publication will be held in Chicago, Illinois, on September 3-5, 2025.The congresses have been enormously productive, incentivizing and publicizing important empirical work into how science is produced, evaluated, published, and disseminated. 2-4However, peer review and scientific publication are currently at a crossroads and their future more difficult than ever to predict.][4][5] We have accumulated a large body of empirical evidence on how systems function and how they can malfunction.][18][19][20][21][22] Research has revealed a rapidly growing list of biases, inefficiencies, and threats to the trustworthiness of published research, some now well recognized, others deserving of more attention. 2,3Moreover, practices continue to change and diversify in response to new needs, tools, and technologies as well as the persistent "publish or perish" pressures on scientists-as-authors.With the continued evolution of electronic platforms and tools-most recently the emergence and use of large language models and artificial intelligence (AI)-peer review and scientific publication are rapidly evolving to address new opportunities and threats. 23,24Moreover, a lot of money is at stake; scientific publishing is a huge market with one of the highest profit margins among all business enterprises, and it supports a massive biomedical and broader science economy.Many stakeholders try to profit from or influence the scientific literature in ways that do not necessarily serve science or enhance its benefits to society.The number of science journal titles and articles is steadily increasing 25 ; many millions of scientists coauthor scientific papers, and perverse reward systems do not help improve the quality of this burgeoning
Risk factors prediction of 6-month mortality after noncardiac surgery of older patients in China: a multicentre retrospective cohort study
Authors: Xiao-Dong Wu, Qian Wang, Yu-Xiang Song, Xian-Yang Chen, Teng Xue, Li-Bin Ma, Yun-Gen Luo, Hao Li, Jing-Sheng Lou, Yan-Hong Liu, Di-Fen Wang, Qing-Ping Wu, Yu-Ming Peng, Wei-Dong Mi, Jiang-Bei Cao
Journal: International Journal of Surgery (2023)

Background: Identifying the risk factors associated with perioperative mortality is crucial, particularly in older patients. Predicting 6-month mortality risk in older patients based on large data sets can assist patients and surgeons in perioperative clinical decision-making. This study aimed to develop a risk prediction model of mortality within 6 months after non-cardiac surgery using the clinical data from 11,894 older patients in China. Materials and Methods: A multicentre, retrospective cohort study was conducted in 20 tertiary hospitals. We retrospectively included 11,894 patients (aged ≥ 65 years) who underwent non-cardiac surgery between April 2020 and April 2022. The least absolute shrinkage and selection operator model based on linear regression was used to analyse and select risk factors, and various machine learning methods were used to build predictive models of 6-month mortality. Results: We predicted 12 preoperative risk factors associated with 6-month mortality in older patients after non-cardiac surgery. Including laboratory-associated risk factors such as mononuclear cell ratio and total blood cholesterol level, etc. Also including medical history associated risk factors such as stroke, history of chronic diseases, etc. By random forest model, we constructed a predictive model with a satisfactory accuracy (area under the receiver operating characteristic curve=0.97). Conclusion: We identified 12 preoperative risk factors associated with 6-month mortality in non-cardiac surgery older patients. These preoperative risk factors may provide evidence for a comprehensive preoperative anaesthesia assessment as well as necessary information for clinical decision-making by anaesthesiologists.
A commentary on ‘BF.7 Omicron subvariant (BA.5.2.1.7) posing fears of a rise in COVID-19 cases again: a critical appraisal and salient counteracting strategies’
Authors: Andi Chen, Xiaohui Chen, Shishi Huang, Xiaochun Zheng
Journal: International Journal of Surgery (2023)

Chen, Andi PhD; Chen, Xiaohui MD, PhD; Huang, Shishi MM; Zheng, Xiaochun MD, PhD Author Information
Oxidized galectin-1 in SLE fails to bind the inhibitory receptor VSTM1 and increases reactive oxygen species levels in neutrophils
Authors: Xu Jiang, Xinyue Xiao, Hao Li, Yiyi Gong, Min Wang, Huaxia Yang, Lidan Zhao, Ying Jiang, Yanping Wei, Chongchong Zhao, Jin Li, Yuling Chen, Shan Feng, Haiteng Deng, Shiliang Ma, Yue Xu, Yudong Liu, George C. Tsokos, Minghong Jiang, Xuan Zhang
Journal: Cellular and Molecular Immunology (2023)
An overview of polyurethane biomaterials and their use in drug delivery
Authors: David Wienen, Thomas Gries, Stuart L. Cooper, Daniel E. Heath
Journal: Journal of Controlled Release (2023)

Polyurethanes are a versatile and highly tunable class of materials that possess unique properties including high tensile strength, abrasion and fatigue resistance, and flexibility at low temperatures. The tunability of polyurethane properties has allowed this class of polymers to become ubiquitous in our daily lives in fields as diverse as apparel, appliances, construction, and the automotive industry. Additionally, polyurethanes with excellent biocompatibility and hemocompatibility can be synthesized, enabling their use as biomaterials in the medical field. The tunable nature of polyurethane biomaterials also makes them excellent candidates as drug delivery vehicles, which is the focus of this review. The fundamental idea we aim to highlight in this article is the structure-property-function relationships found in polyurethane systems. Specifically, the chemical structure of the polymer determines its macroscopic properties and dictates the functions for which it will perform well. By exploring the structure-property-function relationships for polyurethanes, we aim to elucidate the fundamental properties that can be tailored to achieve controlled drug release and empower researchers to design new polyurethane systems for future drug delivery applications.
Academic and Private Partnership to Improve Informed Consent Forms Using a Data Driven Approach
Authors: Craig Tendler, Patricia S. Hong, Conor Kane, Christa Kopaczynski, William Terry, Ezekiel J. Emanuel
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image size DISCLOSURE STATEMENTTendler C, Kane C, Kopaczynski C, and Terry W are employees of Janssen Research & Development, Pharmaceutical Companies of Johnson & Johnson and own stock in Johnson & Johnson. Emanuel E reports speaker honoraria from The Galien Foundation, WellSky, RightWay, Signature Healthcare Foundation, Healthcare Leaders of NY, Medimpact, Massachusetts Association of Health Plans, Philadelphia Committee on Foreign Relations, Yale University, Hartford Medical Society, AAHC Global Innovation Forum, HMSA & Queens Health System, Advocate Aurora Health Summit, University of Pittsburgh Medical Center (UPMC) Shadyside, University of California San Francisco, Advocate Aurora Health, Cain Brothers Conference, Bowdoin College, The Suntory Foundation, Ontario Hospital Association, University of Oklahoma; visiting professor honorarium from Princeton University; support for attending meetings and/or travel from Hartford Medical Society, AAHC Global Innovation Forum, Macalester College, Oak CEO Summit, Advocate Aurora Health Summit, DPharm Conference, UPMC Shadyside, UCSF San Francisco, Cain Brothers Conference, Bowdoin College, Galien Jerusalem Ethics Forum, HLTH 2022 Las Vegas, HMSA Honolulu, Tel Aviv University, The Suntory Foundation, The Ontario Hospital Association, University of Oklahoma, The Quadrangle Retirement Community, Lazard Global Healthcare Leadership Summit; Participation on the following: Village MD (External Advisory Board), Cellares (Board of Advisors), Notable (Occasional Advisor), HIEx Health Innovation Exchange Partnership (Advisory Board Member), JSL Health Fund (Advisory Board Member), WHO COVID-19 Ethics & Governance Working Group (Expert Advisory Member), Biden's Transition COVID-19 Committee (Advisory Board Member), WHO (Special Advisor Board Member), Peterson Center on Healthcare (Advisory Board Member), Clarify Health (Advisor), FeelBetter (Advisory Board), Link Health Technologies (Advisor); Editorial Board Member of the Journal of the American Medical Association; Stock options for Cellares, Notable, Clarify, Korro, Link Health Technologies; JSL Health Fund (Invested in and no management fees); Oak HC/FT Venture Fund (Invested in fund); Council on Foreign Relations (Member), and Center for American Progress (Senior Fellow). Additional informationFundingThis work was supported by Janssen Research and Development LLC.
Preoperative CA19.9 level predicts lymph node metastasis in resectable adenocarcinoma of the head of the pancreas: A further plea for biological resectability criteria
Authors: Alessandro Coppola, Vincenzo La Vaccara, Tommaso Farolfi, Horacio J. Asbun, Ugo Boggi, Kevin Conlon, Bjørn Edwin, Cristina Ferrone, Eduard Jonas, Norihiro Kokudo, Elena Martin Perez, Sohei Satoi, Ernesto Sparrelid, John Stauffer, Alessandro Zerbi, Nobuyuki Takemura, Quirino Lai, Tariq Almerey, Marc Bernon, Roberto Cammarata, Yasmine Djoumi, Tom Gallagher, Poya Ghorbani, Michael Ginesini, Daisuke Hashimoto, Emanuele F Kauffmann, Dyre Kleive, Núria Lluís, Rocio Maqueda González, Niccolò Napoli, Gennaro Nappo, Martina Nebbia, Simone Ricchitelli, Mushegh A. Sahakyan, Tomohisa Yamamoto, Roberto Coppola, Damiano Caputo
Journal: International Journal of Surgery (2023)

Introduction: Lymph-nodal involvement (N+) represents an adverse prognostic factor after pancreatoduodenectomy (PD) for pancreatic adenocarcinoma (PDAC). Preoperative diagnostic and staging modalities lack sensitivity for identifying N+. This study aimed to investigate preoperative CA19.9 in predicting the N+ stage in resectable-PDAC (R-PDAC). Methods: Patients included in a multi-institutional retrospective database of PDs performed for R-PDAC from January 2000 to June 2021 were analyzed. A preoperative laboratory value of CA19.9 &gt;37 U/L was used in univariate and multivariate logistic regression analysis to determine a possible association with N+. Additionally, different cut-offs of CA19.9 related to the preoperative clinical T (cT) stage was assessed to evaluate the risk of N+. Results: A total of 2034 PDs from thirteen centers were included in the study. CA19.9&gt;37 U/L was significantly associated with higher N+ at univariate and multivariate analysis ( P &lt;0.001). CA19.9 levels &gt;37 U/L were associated with N+ in 75.9%, 81.3%, and 85.7% of patients, respectively, in cT1, cT2, and cT3 tumors and with higher cut-off values for all cT stages. Conclusion: Lymph nodal involvement is strongly related to preoperative CA19.9 levels. Specially in patients staged as cT3 the CA 19.9 could represent a valid and easy tool to suspect nodal involvement. Due to these findings, R-PDAC patients with elevated CA19.9 values should be considered in a more biologically advanced stage.
Prognostic variations between ‘primary’ and ‘progressive’ muscle-invasive bladder cancer following radical cystectomy: a novel propensity score-based multicenter cohort study
Authors: Shicong Lai, Jianyong Liu, Chinhui Lai, Samuel Seery, Haopu Hu, Mingrui Wang, Hao Hu, Tao Xu
Journal: International Journal of Surgery (2023)

Objective: To assess prognostic differences between primary and progressive muscle-invasive bladder cancer (MIBC) following radical cystectomy. Material and methods: The Surveillance, Epidemiology, and End Results (SEER) database was used to abstract MIBC data following radical cystectomy from 2000-2019. Patients were classified as either ‘Primary’ MIBC (defined as the presentation of muscle-invasive disease at initial diagnosis) or ‘Progressive’ MIBC (defined as a non-muscle invasive disease that later progressed to MIBC). Baseline characteristics for the two groups were balanced using a propensity score overlap weight (PSOW) technique. Survival differences between the two groups were analyzed using Kaplan-Meier’s plots and log-rank tests. Cox’s proportional hazard regression was used to assess risk factors associated with overall survival (OS) and cancer-specific survival (CSS). Results: 6,632 MIBC patients were identified in the SEER database. Among them, 83.3% (n=5,658) were considered primary MIBC patients, and 16.7% (n=974) were categorized as progressive MIBC patients. Distribution of baseline covariates, including age, sex, race, T stage, N stage, tumor grade, marital status, and chemotherapy, were well-balanced after PSOWs were applied. After stable PSOW adjustments, Kaplan-Meier survival analysis showed that the CSS for progressive MIBC (hazard ratio [HR]=1.25, 95% confidence interval [CI]: 1.12-1.38, P &lt;0.001) was poorer than the primary MIBC group. However, the difference in OS (HR=1.08, 95%CI: 0.99-1.18) was not significant ( P =0.073). Multivariate analysis also suggested that patients with progressive MIBC have significantly poorer CSS (HR=1.24, 95%CI: 1.19-1.38, P &lt;0.001) but not OS (HR=1.08, 95%CI: 0.99-1.18, P =0.089). Conclusion: CSS for progressive MIBC patients appears worse than for those with primary MIBC. This highlights the need to direct more resources for this patient population and particularly for high-risk cases of non-NMIBC, where timely radical surgery will improve patients prognoses.
A commentary on ‘Moderate and severe exacerbations have a significant impact on health-related quality of life, utility, and lung function in patients with chronic obstructive pulmonary disease: a meta-analysis’
Authors: Mei Guo, Qian Jiao, Bo Luo
Journal: International Journal of Surgery (2023)

Department of Geriatrics, Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China, 430063 All data in this article is available for readers. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: E-mail address: [email protected] (B. Luo). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Intravitreal Vascular Endothelial Growth Factor Inhibitor Therapy in Denmark and 5-Year Projections
Authors: Benjamin Sommer Thinggaard, Frederik Pedersen, Jakob Grauslund, Lonny Stokholm
Journal: JAMA Network Open (2023)

This cohort study examines the use of intravitreal injections of vascular endothelial growth factor inhibitor in Denmark from 2007 through 2022 and forecasts future demand for this therapy.
Endoscopic workup in pancreatic cancer
Authors: Roberto Valente, Alessandro Coppola, Chiara Maria Scandavini, Urban Arnelo
Journal: International Journal of Surgery (2023)

Pancreatic cancer is a highly lethal disease with a rising incidence. It is projected to become the second leading cause of cancer-related mortality by 2030. The staging of pancreatic cancer can be broadly categorized into three groups: resectable cancers, locally advanced or borderline resectable cancers, and metastatic cancers. Endoscopy plays a crucial role in the management of pancreatic cancer for the establishment of the diagnosis, for palliation of symptoms due to biliary and/or gastric outlet obstructions, and more recently, for palliative ablation of cancer. The objective of this review is to provide an overview of the endoscopic evaluation and management of patients with pancreatic cancer. It will specifically cover the diagnostic approach utilizing endoscopic ultrasound (EUS), palliative interventions such as endoscopic retrograde cholangiopancreatography (ERCP), and the emerging field of tumor debulking through radiofrequency ablation (RFA).
SAVE Testis-sparing score: a multicenter retrospective study of a novel predictive tool for quantifying testicular tumors
Authors: Zhenhua Liu, Junyi Xie, Xiaofeng Gao, Yuan Lin, Mengkui Sun, Yubo Sun, Ding Peng, Haibiao Xie, Xiangdong Li, Zhiyong Li, Taonong Cai, Pengyu Chen, Zhiming Wu, Shengjie Guo, Yonghong Li, Zhilin Zhang, Zike Qin, Hui Han, Zhisong He, Jiumin Liu, Wen Fu, Shoulin Li, Dan Xia, Xiang Wang, Chunhua Deng, Zhe Xu, Fangjian Zhou, Kai Yao, Wei Yu, Yunlin Ye, Zhuowei Liu
Journal: International Journal of Surgery (2023)

Background: Testis-sparing surgery (TSS) is a safe treatment for patients with benign testicular tumors. Presently, assessments for evaluating the suitability of TSS are poorly standardized, partially because testicular anatomical elements cannot be quantitatively described. Materials and Methods: We developed a scoring method known as SAVE testis-sparing score based on four critical and accessible anatomical features of testicular tumor. The SAVE score ranges from 0 to 8 and is divided into four risk classes ( low , medium , high , and extremely high ) to evaluate the feasibility of TSS, wherein low risk indicates high feasibility and vice versa. This study included 444 testicular tumor patients from eight centers. Among them, 216 patients (model group: 151 patients, validation group: 65 patients) were included in the modeling analysis, and the other 228 patients from children’s centers were included in the proportion analysis. Using retrospective data, patient characteristics associated with surgical methods were identified. Furthermore, multivariate logistic regression model was built quantify the associations between these characteristics and the surgery method. The receiver operator characteristic curve was used to evaluate the classification efficiency of SAVE. Results: The SAVE testis-sparing score includes size (tumor size as maximal diameter), available testicular tissue volume, volume ratio of the tumor to the testis, and the exophytic / endophytic properties of the tumor. The SAVE scoring system accurately classified the suitability of TSS based on the complexity of benign testicular tumors. Conclusion: The SAVE score is a reproducible and robust tool for quantitatively describing the anatomical characteristics of benign testicular tumors and guide the preoperative evaluation of TSS.