tbuckley/cabot-search huggingface dataset:
Teaching unleashes expression
Authors: Peter Gärdenfors
Journal: Behavioral and Brain Sciences (2023)

Abstract I propose that the evolution of teaching has been central in extending manipulative intentions. Demonstrating may be the evolutionarily first form of expression that is productive, ostensive, and involves informative intention. Demonstration also involves theory of mind. Then pantomime goes a step further and involves a communicative intention. Pantomime can thereby function as displaced communication used for more complex expressions.
Ostensive communication, market exchange, mindshaping, and elephants
Authors: Don Ross
Journal: Behavioral and Brain Sciences (2023)

Abstract Heintz &amp; Scott-Phillips's hypothesis that the topic range and type diversity of human expressive communication gains support from consilience with prior accounts of market exchange as fundamental to unique human niche construction, and of mindshaping as much more important than mindreading. The productivity of the idea is illustrated by the light it might shed on why elephants seem to engage in continuous social communication for little evident purpose.
Breast Cancer and Physiologic Avidity From Breast Feeding on FDG PET/CT
Authors: Gary A. Ulaner
Journal: Clinical Nuclear Medicine (2023)

A 35-year-old woman presented with breast cancer diagnosed during pregnancy. Eleven days after delivery, the patient underwent FDG PET/CT for systemic staging. Avidity was seen diffusely in both breasts, with a more avid focus at the site of a biopsy clip in the right breast. There were no lymph nodes or distant metastases. The patient was actively breast feeding, explaining the diffuse breast avidity. This case demonstrates both malignant and benign FDG avidity in the breasts at the same time, with a focal FDG-avid right breast malignancy identified among bilateral breast parenchyma with elevated physiologic FDG-avid secondary to breast feeding.
Primates unleashed
Authors: Federica Amici, Katja Liebal
Journal: Behavioral and Brain Sciences (2023)

Abstract Before claiming major differences between the communication systems of humans and other species, it is necessary to (1) overcome methodological limitations in the comparative study of communicative intentions; (2) account for mechanisms other than epistemic vigilance that may also sustain complex forms of communication; and (3) better differentiate between motivational and cognitive factors potentially affecting the emergence of open-ended communication.
<i>Limosilactobacillus reuteri</i> normalizes blood–brain barrier dysfunction and neurodevelopment deficits associated with prenatal exposure to lipopolysaccharide
Authors: Jing Lu, Xiaobing Fan, Lei Lu, Yueyue Yu, Erica Markiewicz, Jessica C. Little, Ashley M. Sidebottom, Erika C. Claud
Journal: Gut Microbes (2023)

Maternal immune activation (MIA) derived from late gestational infection such as seen in chorioamnionitis poses a significantly increased risk for neurodevelopmental deficits in the offspring. Manipulating early microbiota through maternal probiotic supplementation has been shown to be an effective means to improve outcomes; however, the mechanisms remain unclear. In this study, we demonstrated that MIA modeled by exposing pregnant dams to lipopolysaccharide (LPS) induced an underdevelopment of the blood vessels, an increase in permeability and astrogliosis of the blood-brain barrier (BBB) at prewean age. The BBB developmental and functional deficits early in life impaired spatial learning later in life. Maternal Limosilactobacillus reuteri (L. reuteri) supplementation starting at birth rescued the BBB underdevelopment and dysfunction-associated cognitive function. Maternal L. reuteri-mediated alterations in β-diversity of the microbial community and metabolic responses in the offspring provide mechanisms and potential targets for promoting BBB integrity and long-term neurodevelopmental outcomes.
What semantic dementia tells us about the ability to infer others' communicative intentions
Authors: François Osiurak, Giovanni Federico
Journal: Behavioral and Brain Sciences (2023)

Abstract As Heintz &amp; Scott-Phillips rightly argued, pragmatics has been too commonly considered as a supplement to linguistic communication. Their aim to reorient the study of cognitive pragmatics as the foundation of many distinctive features of human behavior finds echo in the neuropsychological literature on tool use, in which the investigation of semantic dementia challenges the classical semantics versus pragmatics dissociation.
Putting the cart before the horse? The origin of information donation
Authors: Judith M. Burkart, Sandro Sehner, Rahel K. Brügger, Jessie E. C. Adriaense, Carel P. van Schaik
Journal: Behavioral and Brain Sciences (2023)

Abstract Heintz &amp; Scott-Phillips propose that the partner choice ecology of our ancestors required Gricean cognitive pragmatics for reputation management, which caused a tendency toward showing and expecting prosociality that subsequently scaffolded language evolution. Here, we suggest a cognitively leaner explanation that is more consistent with comparative data and posits that prosociality and eventually language evolved along with cooperative breeding.
Illustrating continuity between linguistic and non-linguistic human communication and expression
Authors: Martin Stehberger
Journal: Behavioral and Brain Sciences (2023)

Abstract This commentary presents two illustrations, from the world of poker, of the continuity between linguistic and non-linguistic communication and expression, in support of Heintz &amp; Scott-Phillips's account of the evolution of human expression and communication. I also come across the presumption of relevance in the context of a poker table.
Perioperative versus postoperative calcium and vitamin D supplementation to prevent symptomatic hypocalcemia after total thyroidectomy: a randomized placebo controlled trial
Authors: Pichit Sittitrai, Donyarat Ruenmarkkaew, Hanpon Klibngern, Tapanut Ariyanon, Nutthiya Hanprasertpong, Somkamon Boonyaprapa, Maysayawan Sreesawat
Journal: International Journal of Surgery (2023)

Hypocalcemia is the most common complication following total thyroidectomy. This study aimed to evaluate the efficacy of perioperative combined calcium and vitamin D supplementation compared to postoperative combined calcium and vitamin D supplementation in reducing symptomatic hypocalcemia.A prospective randomized placebo-controlled trial was carried out in patients undergoing total or completion thyroidectomy from June 2017 to May 2022. Eligible patients were assigned to receive either calcium carbonate and alfacalcidol or placebo 3 days before surgery, and both groups were given calcium carbonate and alfacalcidol for 14 days after surgery. Clinical outcomes (signs and symptoms of hypocalcemia, requirement of intravenous calcium, and medication-induced hypercalcemia) and laboratory results (calcium and parathyroid hormone levels) were compared between the two groups.One hundred and thirty-four patients were included in the analysis, 68 were in perioperative oral calcium and vitamin D supplementation group, and 66 were in postoperative oral calcium and vitamin D supplementation group. Symptomatic hypocalcemia rates were significantly lower in the perioperative group than in the postoperative group (8.8 and 22.7%, respectively, P=0.033). All symptomatic hypocalcemia cases in the perioperative group occurred in the first 24 hours after surgery. Mean calcium levels were significantly higher in the perioperative group at 24 and 48 hours after surgery. Intravenous calcium requirement rate was lower in the perioperative group but the difference was insignificant (2.9 and 12.1%, P=0.053). Mean parathyroid hormone levels were within the normal range and did not differ between groups. No medication-induced hypercalcemia was detected in either group.Perioperative oral calcium and vitamin D supplementation significantly decreased the risks of symptomatic and biochemical hypocalcemia compared to postoperative oral calcium and vitamin D supplementation. The perioperative supplementation also shortened the recovery period of symptomatic hypocalcemia to within 24 hours.
A commentary on ‘systematic review and meta-analysis of randomized controlled trials of perioperative outcomes and prognosis of transurethral en-bloc resection versus conventional transurethral resection for nonmuscle-invasive bladder cancer’ (Int J Surg 2022; 104:106777)
Authors: Zhiyong Tan, Haifeng Wang, Jiansong Wang
Journal: International Journal of Surgery (2023)
Extensive Extramedullary Involvement at Presentation in B-Cell Acute Lymphoblastic Leukemia
Authors: Siddharth Sharma, Vijay Singh, Manish Ora, Aftab Hasan Nazar, Sanjay Gambhir
Journal: Clinical Nuclear Medicine (2023)

Extensive extramedullary involvement as presentation is uncommon in pediatric B-cell acute lymphoblastic leukemia. A 7-year-old boy was diagnosed with painless parotid gland enlargement. He had pancytopenia and significantly raised serum lactate dehydrogenase. Fine-needle aspiration cytology from the parotid was suggestive of lymphoid malignancy. Flow cytometry and bone marrow biopsy suggested B-cell acute lymphoblastic leukemia. 18 F-FDG PET/CT revealed extensive bone marrow disease and the involvement of the spleen, pancreas, kidneys, and the parotid, submandibular, and lacrimal glands. He had negligible physiological brain uptake.
The co-evolution of cooperation and communication: Alternative accounts
Authors: Nima Mussavifard, Gergely Csibra
Journal: Behavioral and Brain Sciences (2023)

Abstract We challenge the proposal that partner-choice ecology explains the evolutionary emergence of ostensive communication in humans. The good fit between these domains might be because of the opposite relation (ostensive communication promotes the evolution of cooperation) or because of the dependence of both these human-specific traits on a more ancient contributor to human cognitive evolution: the use of technology.
Malignant Peritoneal Mesothelioma With Butterfly-Shaped Muscle Metastasis
Authors: Jian Li, Jinhui Yang, Shuo Hu
Journal: Clinical Nuclear Medicine (2023)

Malignant peritoneal mesothelioma is a rare malignancy that may manifest as extraperitoneal metastasis. We describe the findings of 68 Ga-FAPI and 18 F-FDG PET/CT in a case of malignant peritoneal mesothelioma with widespread muscle metastasis in a butterfly-shaped distribution pattern. We found that FDG and FAPI uptake in the peritoneal tumor and its spread were inhomogeneous. Notably, 68 Ga-FAPI PET/CT more clearly showed relevant lesions compared with 18 F-FDG PET/CT.
The scaffolded evolution of human communication
Authors: Walter Veit, Heather Browning
Journal: Behavioral and Brain Sciences (2023)

Abstract Heintz &amp; Scott-Phillips provide a useful synthesis for constructing a bridge between work by both cognitive scientists and evolutionary biologists studying the diversity of human communication. Here, we aim to strengthen their bridge from the side of evolutionary biology, to argue that we can best understand ostensive communication as a scaffold for more complex forms of intentional expressions.
Archaic humans have contributed to large-scale variation in modern human T cell receptor genes
Authors: Martin Corcoran, Mark Chernyshev, Marco Mandolesi, Sanjana Narang, Mateusz Kaduk, Kewei Ye, Christopher Sundling, Anna Färnert, Taras Kreslavsky, Carolina Bernhardsson, Maximilian Larena, Mattias Jakobsson, Gunilla B Karlsson Hedestam
Journal: Immunity (2023)

Human T cell receptors (TCRs) are critical for mediating immune responses to pathogens and tumors and regulating self-antigen recognition. Yet, variations in the genes encoding TCRs remain insufficiently defined. Detailed analysis of expressed TCR alpha, beta, gamma, and delta genes in 45 donors from four human populations-African, East Asian, South Asian, and European-revealed 175 additional TCR variable and junctional alleles. Most of these contained coding changes and were present at widely differing frequencies in the populations, a finding confirmed using DNA samples from the 1000 Genomes Project. Importantly, we identified three Neanderthal-derived, introgressed TCR regions including a highly divergent TRGV4 variant, which mediated altered butyrophilin-like molecule 3 (BTNL3) ligand reactivity and was frequent in all modern Eurasian population groups. Our results demonstrate remarkable variation in TCR genes in both individuals and populations, providing a strong incentive for including allelic variation in studies of TCR function in human biology.
Multi-Maintenance Olaparib Therapy in Relapsed, Germline <i>BRCA1/2</i>-Mutant High-Grade Serous Ovarian Cancer (MOLTO): A Phase II Trial
Authors: Robert D. Morgan, Andrew R. Clamp, Daniel J. White, Marcus Price, George J. Burghel, W. David J. Ryder, Reem D. Mahmood, Alexander D. Murphy, Jurjees Hasan, Claire L. Mitchell, Zena Salih, Chelsey Wheeler, Emma Buckley, Joanna Truelove, Georgia King, Yasmina Ainaoui, Sanjeev S. Bhaskar, Joseph Shaw, D. Gareth R. Evans, Bedirhan Kilerci, Simon P. Pearce, Gerard Brady, Caroline Dive, James P.B. O'Connor, Andrew J. Wallace, Dominic G. Rothwell, Richard J. Edmondson, Gordon C. Jayson
Journal: Clinical Cancer Research (2023)

Abstract Purpose: A single maintenance course of a PARP inhibitor (PARPi) improves progression-free survival (PFS) in germline BRCA1/2-mutant high-grade serous ovarian cancer (gBRCAm-HGSOC). The feasibility of a second maintenance course of PARPi was unknown. Patients and Methods: Phase II trial with two entry points (EP1, EP2). Patients were recruited prior to rechallenge platinum. Patients with relapsed, gBRCAm-HGSOC were enrolled at EP1 if they were PARPi-naïve. Patients enrolled at EP2 had received their first course of olaparib prior to trial entry. EP1 patients were retreated with olaparib after RECIST complete/partial response (CR/PR) to platinum. EP2 patients were retreated with olaparib ± cediranib after RECIST CR/PR/stable disease to platinum and according to the platinum-free interval. Co-primary outcomes were the proportion of patients who received a second course of olaparib and the proportion who received olaparib retreatment for ≥6 months. Functional homologous recombination deficiency (HRD), somatic copy-number alteration (SCNA), and BRCAm reversions were investigated in tumor and liquid biopsies. Results: Twenty-seven patients were treated (EP1 = 17, EP2 = 10), and 19 were evaluable. Twelve patients (63%) received a second course of olaparib and 4 received olaparib retreatment for ≥6 months. Common grade ≥2 adverse events during olaparib retreatment were anemia, nausea, and fatigue. No cases of MDS/AML occurred. Mean duration of olaparib treatment and retreatment differed (12.1 months vs. 4.4 months; P &amp;lt; 0.001). Functional HRD and SCNA did not predict PFS. A BRCA2 reversion mutation was detected in a post-olaparib liquid biopsy. Conclusions: A second course of olaparib can be safely administered to women with gBRCAm-HGSOC but is only modestly efficacious. See related commentary by Gonzalez-Ochoa and Oza, p. 2563
Benzodiazepine Receptor Agonists Prescribing for Insomnia Among Adults in Primary Health Care Facilities in Beijing, China
Authors: Mengyuan Fu, Yuezhen Zhu, Zhiwen Gong, Can Li, Huangqianyu Li, Luwen Shi, Xiaodong Guan
Journal: JAMA Network Open (2023)

This cross-sectional study examines the benzodiazepine receptor agonists (BZRA) prescribing rate for insomnia among adult patients in primary health care facilities (PHFs) in China.
Antipsychotic Medication Use Among Older Adults Following Infection-Related Hospitalization
Authors: Yichi Zhang, James M. Wilkins, Lily Gui Bessette, Cassandra York, Vincent Wong, Kueiyu Joshua Lin
Journal: JAMA Network Open (2023)

Importance There are limited data on discontinuation rates of antipsychotic medications (APMs) used to treat delirium due to acute hospitalization in the routine care of older adults. Objective To investigate discontinuation rates and patient characteristics of APMs used to treat delirium following infection-related hospitalization among older US adults. Design, Setting, and Participants This retrospective cohort study was conducted using US claims data (Optum’s deidentified Clinformatics Data Mart database) for January 1, 2004, to May 31, 2022. Patients were aged 65 years or older without prior psychiatric disorders and had newly initiated an APM prescription within 30 days of an infection-related hospitalization. Statistical analysis was performed on December 15, 2022. Exposures New use (no prior use any time before cohort entry) of oral haloperidol and atypical APMs (aripiprazole, olanzapine, quetiapine, risperidone, etc). Main Outcomes and Measures The primary outcome was APM discontinuation, defined as a gap of more than 15 days following the end of an APM dispensing. Survival analyses and Kaplan-Meier analyses were used. Results Our study population included 5835 patients. Of these individuals, 790 (13.5%) were new haloperidol users (mean [SD] age, 81.5 [6.7] years; 422 women [53.4%]) and 5045 (86.5%) were new atypical APM users (mean [SD] age, 79.8 [7.0] years; 2636 women [52.2%]). The cumulative incidence of discontinuation by 30 days after initiation was 11.4% (95% CI, 10.4%-12.3%) among atypical APM users and 52.1% (95% CI, 48.2%-55.7%) among haloperidol users ( P &amp;amp;lt; .001 for difference between haloperidol vs atypical APMs). We observed an increasing trend in discontinuation rates from 2004 to 2022 (5% increase [95% CI, 3%-7%] per year) for haloperidol users (adjusted hazard ratio, 1.05 [1.03-1.07]; P &amp;amp;lt; .001) but not for atypical APM users (1.00 [0.99-1.01]; P = .67). Prolonged hospitalization and dementia were inversely associated with the discontinuation of haloperidol and atypical APMs. Conclusions and Relevance The findings of this cohort study suggest that the discontinuation rate of newly initiated APMs for delirium following infection-related hospitalization was lower in atypical APM users than in haloperidol users, with prolonged hospitalization and dementia as major associated variables. The discontinuation rate was substantially higher in recent years for haloperidol but not for atypical APMs.
Preventing postoperative cognitive dysfunction using anesthetic drugs in elderly patients undergoing noncardiac surgery: a systematic review and meta-analysis
Authors: Kuan Zeng, Jingyi Long, Yi Li, Jichang Hu
Journal: International Journal of Surgery (2023)

Postoperative cognitive dysfunction (POCD) is a common neurological system disorder in surgical patients. The choice of anesthetic can potentially reduce POCD. The authors performed this network meta-analysis to compare different anesthetic drugs in reducing the incidence of POCD for elderly people undergoing noncardiac surgery. We searched MEDLINE, EMBASE, the Cochrane Library, and the Web of Science for randomized controlled trials comparing the different anesthetic drugs for noncardiac surgery in elderly from inception until July, 2022. The protocol was registered on the PROSPERO database (CRD#42020183014). A total of 34 trials involving 4314 patients undergoing noncardiac surgery in elderly were included. The incidence of POCD for each anesthetic drug was placebo (27.7%), dexmedetomidine (12.9%), ketamine (15.2%), propofol (16.8%), fentanyl (23.9%), midazolam (11.3%), sufentanil (6.3%), sevoflurane (24.0%), and desflurane (28.3%). Pairwise and network meta-analysis showed dexmedetomidine was significantly reducing the incidence of POCD when compared with placebo. Network meta-analysis also suggested dexmedetomidine was significantly reducing the incidence of POCD when compared with sevoflurane. Sufentanil and dexmedetomidine ranked the first and second in reducing the incidence of POCD with the surface under the cumulative ranking curve value of 87.4 and 81.5%. Sufentanil and dexmedetomidine had the greatest possibility to reduce the incidence of POCD for elderly people undergoing noncardiac surgery.
p16 INK4A drives nonalcoholic fatty liver disease phenotypes in high fat diet fed mice through biliary E2F1/FOXO1/IGF-1 signaling
Authors: Debjyoti Kundu, Lindsey Kennedy, Tianhao Zhou, Burcin Ekser, Vik Meadows, Amelia Sybenga, Konstantina Kyritsi, Lixian Chen, Ludovica Ceci, Nan Wu, Chaodong Wu, Shannon Glaser, Guido Carpino, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Heather Francis
Journal: Hepatology (2023)

NAFLD is characterized by steatosis, hepatic inflammation, and fibrosis, which can develop into NASH. Patients with NAFLD/NASH have increased ductular reaction (DR) and biliary senescence. High fat/high cholesterol diet feeding increases biliary senescence, DR, and biliary insulin-like growth factor-1 (IGF-1) expression in mice. p16/IGF-1 converges with fork-head box transcription factor O1 (FOXO1) through E2F1. We evaluated p16 inhibition on NAFLD phenotypes and biliary E2F1/FOXO1/IGF-1 signaling.4-week wild-type (C57BL/6J) male mice were fed a control diet (CD) or high fat/high cholesterol diet and received either p16 or control Vivo Morpholino (VM) by tail vein injection 2× during the 16th week of feeding. We confirmed p16 knockdown and examined: (i) NAFLD phenotypes; (ii) DR and biliary senescence; (iii) serum metabolites; and (iv) biliary E2F1/FOXO1/IGF-1 signaling. Human normal, NAFLD, and NASH liver samples and isolated cholangiocytes treated with control or p16 VM were evaluated for p16/E2F1/FOXO1/IGF-1 signaling. p16 VM treatment reduced cholangiocyte and hepatocyte p16. In wild-type high fat/high cholesterol diet mice with control VM, there were increased (i) NAFLD phenotypes; (ii) DR and biliary senescence; (iii) serum metabolites; and (iv) biliary E2F1/FOXO1/IGF-1 signaling; however, p16 VM treatment reduced these parameters. Biliary E2F1/FOX-O1/IGF-1 signaling increased in human NAFLD/NASH but was blocked by p16 VM. In vitro , p16 VM reduced biliary E2f1 and Foxo1 transcription by inhibiting RNA pol II binding and E2F1 binding at the Foxo1 locus, respectively. Inhibition of E2F1 reduced biliary FOXO1 in vitro.Attenuating hepatic p16 expression may be a therapeutic approach for improving NAFLD/NASH phenotypes.
No unleashed expression without language
Authors: Robyn Carston
Journal: Behavioral and Brain Sciences (2023)

Abstract While the metarepresentational structure of ostensive communication may explain the unleashing of human expression, it neither explains the open-endedness of the thoughts expressed/communicated, nor how the multiply embedded nature of the metarepresentational structure invoked arose. These both require the recursivity of human language, a capacity which must be distinguished from external (public) languages and their use in communication.