tbuckley/cabot-search huggingface dataset:
A Text-Book of Human Physiology, Including a Section on Physiologic Apparatus.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Noncytolytic Extraction of Murine Tumor-Specific Transplantation Antigens With the Nonionic Detergent Octyl-β-&lt;sc&gt;d&lt;/sc&gt;-glucopyranoside&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Stephen J. LeGrue, Catherine M. Macek, Barry D. Kahan
Journal: JNCI Journal of the National Cancer Institute (1982)

The nonionic detergent octyl-β-d-glucopyranoside (C8Glu) was used to extract immunogenic tumor-specific transplantation antigen (TSTA) from intact cells and purified plasma membranes of the 3-methylcholanthrene-induced fibrosarcoma MCA-F. Pretreatment of syngeneic C3H/HeJ mice with 100 μg of C8Glu extracts induced specific immunoprotection such that mice resisted the outgrowth of MCA-F but not the antigenically distinct tumors MCA-D or MCA-2A. Incubation of intact cells with 7 mM (0.2%) C8Glu for 30 minutes at 23°C was judged to be noncytolytic because extracted cells excluded trypan blue. Preparative isoelectric focusing partially purified the MCA-F-specific antigen from crude C8Glu extracts into the pH 6.5–6.8 region of the gradient. Electrofocusing yielded 60% of the applied antigen activity and a fourfold to fivefold increase in specific activity. In addition, immunoprotective activity was obtained in 2% C8Glu extracts of MCA-F plasma membranes, confirming the membrane localization of the MCA-F TSTA. Three properties of C8Glu rendered it an attractive agent for the preparation of cell surface proteins: a nonionic character, large critical micellar concentration, and its capacity to extract antigens without complete membrane solubilization or cell disruption.
Editorial board and contents
Authors: Rhiannon Macrae, Milka Kostic, Basil Nyaku, Ria Otten, Patrick Scheffmann, S Gasser, Y Hayashizaki, S Henikoff, H Horvitz, L Hurst, E Koonin, E Meyerowitz, S Moreno, A Nieto, Spain Ponting, J Wysocka, Nizar Fawal, Qiang Li, Catherine Mathé, Christophe Dunand, Felix Dietlein, Lisa Thelen, H Reinhardt, Hong-Dong Li, Rajasree Menon, Gilbert Omenn, Yuanfang Guan, Keith Vance, Chris Ponting, Anja Hohmann, Christopher Vakoc, Thomas Gregor, Hernan Garcia, Shawn Little
Journal: Trends in Genetics (2014)
Abnormal mammograms with no lump
Authors: S J Leinster
Journal: BMJ (1982)

3 6 ±0 3 versus 4 5 ±0 4 units) and a reduced hospital stay (7-2±007 versus 8 6±0 8 days) in patients receiving ranitidine compared with those receiving cimetidine.Surgery was necessary in one of the 18 patients in the ranitidine group compared with three of the 19 patients in the cimetidine group.As Professor Langman and Dr Henry imply, the mechanism of the protective effect of ranitidine is unknown and clearly requires further study.The encouraging preliminary results with ranitidine in the three studies so far reported, however, emphasise the importance of continuing further evaluation of this drug.
Handbook of Communicable Diseases
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CLINICAL HISTORY OF THE CASE OF PRESIDENT JAMES ABRAM GARFIELD.
Authors: ROBERT REYBURN
Journal: JAMA (1894)

I ASSASSINATION OF PRESIDENT GARFIELD. On the morning of July 2,1881, President Garfield accompanied by Secretary Blaine drove up to the R Street entrance of the Baltimore and Potomac depot, Washington, D. C, intending with a party composed of members of his family, Cabinet and personal friends, to take a pleasure trip through the New England States. At 9:30 A.M. President Garfield and Secretary Blaine were walking across the ladies' reception room on their way to take the train, when a pistol shot was heard, which was immediately followed by a second report. There was a rush of those who· were present to the reception room, where the President was found lying on the floor with blood streaming from two wounds, one a slight fleeh wound of the right arm, and one of the right eide of the body. The President turned at the first shot, and fell on his
World Hepatitis Day — July 28, 2015
Authors: Kiren Mitruka, Tengiz Tsertsvadze, Maia Butsashvili, Amiran Gamkrelidze, Paata Sabelashvili, Ekaterine Adamia, Mari Chokheli, Jan Drobeniuc, Liesl Hagan, Aaron Harris, Tea Jiqia, Ana Kasradze, Stephen Ko, Vakhtang Qerashvili, Lali Sharvadze, Irina Tskhomelidze, Valeri Kvaratskhelia, Juliette Morgan, John Ward, Francisco Averhoff, Thomas Frieden, Harold Jaffe, Joanne Cono, Chesley Richards, Michael Iademarco, Sonja Rasmussen, Charlotte Kent, Jacqueline Gindler, Acting Editor, Teresa Rutledge, Douglas Weatherwax, Teresa Hood, Jude Rutledge, Martha Boyd, Maureen Leahy, Julia Martinroe, Stephen Spriggs, Brian Wood, Quang Doan, Phyllis King, Teresa Moreland, Terraye Starr, Timothy Jones, Matthew Boulton, Ann Arbor, Virginia Mi, Jonathan Caine, Los Fielding, David Angeles, William Fleming, King Halperin, Rima Khabbaz, Patricia Quinlisk, Patrick Remington, William Roper, William Schaffner, Maia Alkhazashvili, Gvantsa Chanturia, Nazibrola Chitadze, Roena Sukhiashvili, Konstantin Gvetadze, Lana Gatserelia, Nikoloz Chkhartishvili, Prathit Kulkarni, Mary Duncan, Michelle Watters, Leah Graziano, Elena Vaouli, Larry Cseh, John Risher, Maureen Orr, Tai Hunte-Ceasar, Esther Ellis, Louise Watkins, Lauren Drinkard
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

marks the fifth annual World Hepatitis Day, established in 2010 by the World Health Organization to increase awareness and understanding of viral hepatitis.Millions of acute hepatitis infections occur each year, and approximately 400 million persons are living with chronic hepatitis B or hepatitis C (1).An estimated 1.4 million persons die each year from the various forms of viral hepatitis (1).The theme of this year's World Hepatitis Day is "Prevent Hepatitis.Act Now." Key messages will focus on risks, safe injection practices, vaccination, and testing and treatment.This issue of MMWR includes a report describing the launch of a nationwide hepatitis C elimination program in Georgia, a country with a high burden of hepatitis C. The initial phase of the program is focused on increasing access to affordable diagnostics, free treatment of persons with severe liver disease who are at highest risk for hepatitis C-related morbidity and mortality with new curative regimens, and building capacity to achieve program goals of prevention of transmission and elimination of disease.Georgia's program might provide information and experience that can inform similar efforts in other parts of the world.A second report summarizes viral hepatitis surveillance and outbreak data from a national surveillance system in India for epidemic-prone diseases.This report sheds light on the burden and epidemiology of acute viral hepatitis in India, particularly hepatitis A and E, and highlights the important role that routine hepatitis surveillance can play in guiding prevention efforts.
Diseases of the Nervous System, Resulting from Accident and Injury.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Looks like smooth sailing for experimental hepatitis B vaccine
Authors: William A. Check
Journal: JAMA (1981)

The recently developed vaccine against hepatitis B virus is both extremely safe and highly effective, according to results presented at the recent meeting of the Advisory Committee on Immunization Practices of the Centers for Disease Control (CDC). A complete course of vaccine administration provides a high probability of an immune response, virtually complete protection from infection in recipients who do mount an immune response, and a negligible incidence of side effects, according to data presented by James Maynard, MD, PhD, and Donald Francis, MD, DSc, of the CDC's Hepatitis B Laboratory in Phoenix, Ariz, who coordinated the multicenter trial. This outcome should provide further impetus for approval of the vaccine, which is expected to be available in the spring or early summer of 1982. The advisory committee will need the intervening time to address some of the difficult questions concerning administration of the vaccine, according to committee chairwoman Catherine Wilfert,
Serum Creatinine and Renal Function in the Elderly
Authors: Paul J. Hering
Journal: JAMA (1982)

<h3>To the Editor.—</h3> We enjoyed Dr Gifford's article entitled "Isolated Systolic Hypertension in the Elderly" (1982;247:781). We would like to comment, however, on his statement that "serum creatinine level estimates renal function." With the decline in lean body mass with age, daily endogenous creatinine production decreases. Therefore, creatinine clearance must fall to a greater extent in the elderly before the serum creatinine level increases. This has recently been emphasized by Ouslander<sup>1</sup>in a review of drug therapy in the elderly. The serum creatinine level may fall within the normal range in an elderly patient who has notable impairment of his renal function.<sup>2</sup>A useful nomogram to estimate creatinine clearance in relation to age has been devised<sup>3</sup>: creatinine clearance = [(140-age) × body weight, kg]/[72 × serum creatinine] (multiply by 0.85 for females). This estimation is especially important when prescribing any medication that is eliminated by the kidney.
Pilot study of ribavirin and interferon-β for chronic hepatitis B
Authors: Shinichi Kakumu, Kentaro Yoshioka, Takaji Wakita, Tetsuya Ishikawa, Masahiro Takayanagi, Yasuyuki Higashi
Journal: Hepatology (1993)

Ribavirin is a nucleoside analog that inhibits the replication of many DNA and RNA viruses. To evaluate the efficacy of oral ribavirin, we randomly assigned 24 HBeAg-positive patients with chronic active hepatitis to a 12-wk course of treatment with 0.8 to 1.0 gm/ribavirin day, 3 mU interferon-β three times a week intravenously or a combination of those drugs. Ribavirin, alone and in combination with interferon-β, decreased hepatitis B virus levels in most patients, and mean serum hepatitis B virus DNA and DNA polymerase levels at the end of treatment were approximately half of baseline levels (p &lt; 0.05). Interferon alone exerted the most inhibitory effect on hepatitis B virus activity (p &lt; 0.01). During ribavirin treatment, changes in serum aminotransferase values varied considerably and the mean values did not change significantly, although interferon alone and the combination of interferon and ribavirin were associated with significant reductions in serum aminotransferase activities. Ribavirin was well tolerated, but we transiently reduced the dosage in two cases because of mild hemolytic anemia, although all patients completed the treatment schedule. The combination of interferon and ribavirin did not appear to result in greater toxicity. During the follow-up period (6 to 9 mo), HBeAg and hepatitis B virus DNA disappeared in one patient treated with ribavirin, in two treated with interferon and in two given the combination. These results indicate that ribavirin suppresses hepatitis B virus replication, although its effect is less than that of interferon, and that it may be useful as adjunctive therapy for chronic hepatitis B. Simultaneous administration of ribavirin and interferon does not appear to potentiate the beneficial effect and may even inhibit the effect of interferon. (Hepatology 1993;18:258-263).
Highlights of This Issue
Journal: Clinical Cancer Research (2014)

Manipulation of the apoptosis pathway is an appealing strategy for cancer treatment using BH3 mimetics such as ABT-263, although predictive biomarkers are required to identify patients who may benefit from their use.To investigate this problem, Suryani and colleagues studied the in vivo efficacy of ABT-263 against 31 pediatric acute lymphoblastic leukemia xenografts.High MCL1 expression and function correlated with in vivo ABT-263 resistance, and in vitro assays predicted in vivo ABT-263 responses.These approaches could be included in the design of prospective clinical trials to determine if they can identify patients who may respond to treatment with this class of therapeutic agents.
Verruciform xanthoma in association with a vulval fibroepithelial polyp
Authors: S. KISHIMOTO, H. TAKENAKA, R. SHIBAGAKI, M. NAGATA, H. YASUNO
Journal: British Journal of Dermatology (1997)

Summary We report the clinical, light microscopic, immunohistochemical and ultrastructural features of a verruciform xanthoma that developed in association with a vulval fibroepithelial polyp. To our knowledge, this is the first time that this association has been reported. Immunohistochemical findings confirmed that the xanthoma cells were of a monocyte/macrophage lineage. In addition to typical histological characteristics, prominent vascular ectasias were detected in the deep dermis at the periphery of this lesion. The ectasias may play a part in pathogenesis.
Primary Disseminated Pulmonary Aspergillosis With Metastatic Skin Nodules
Authors: James S. Vedder
Journal: JAMA (1969)

The diagnosis of extensive pulmonary aspergillosis with multiple metastatic skin lesions was established in a 3 1/2-year-old female child who had had no prior debilitating disease. The hyphae of<i>Aspergillus</i>were identified in both the skin and lung biopsies. In addition,<i>A fumigatus</i>was cultured from the lung biopsy material. A reversal and clearing of the disease process occurred in both the lungs and skin after a few weeks of aerosol nystatin therapy. Measurable levels of nystatin were found in the blood after inhalation therapy, but no nystatin could be measured after oral administration alone.
Brief Focal Seizures vs Petit Mal Epilepsy
Authors: Janice R. Stevens
Journal: JAMA (1966)

In an instructive and timely article appearing recently in thisJournal, Livingston et al gave a lucid presentation of the modern concept of petit mal epilepsy, sharply delimiting this disorder to the brief warningless seizures which occur almost solely in childhood and which are associated with a rhythmic 3 to 3 1/2-cycle per second (cps) spikewave pattern on the electroencephalogram. As he pointed out, true petit mal, thus defined, comprises only 2.3% of all epilepsies in the general population and from 6% to 12% of childhood convulsive disorders. In the present communication, an attempt is made to give an equally unambiguous picture of brief epileptic seizures which do not conform to this current concept of petit mal, but which are commonly diagnosed as such, often to the serious detriment of the patient concerned. These brief seizures, in contrast to "true" petit mal, are widely distributed among all age groups and
Psychosocial Factors in Riots—Old and New
Authors: JOHN P. SPIEGEL
Journal: American Journal of Psychiatry (1968)

The author gives a historical review of three main types of violence in the U. S. and their social and psychological causes. He feels that we have been more willing to settle for violence than to attend to the social conflicts which generate it. Using an analogy from psychotherapy, he says a first step toward dealing with the underlying problem would be acknowledging its existence; then we should approach its solution through attempts to share power with previously excluded groups.
New drugs selectively inhibit kidney stone formation
Authors: Charles Marwick
Journal: JAMA (1983)

General treatment of urolithiasis is yielding to specific agents for particular types of kidney stones. Last December, the Food and Drug Administration approved sodium cellulose phosphate (SCP) for the treatment of one type of calcium stone. Last month, it approved acetohydroxamic acid (AHA) for prevention of so-called struvite stones. Now a third agent— potassium citrate, which inhibits the formation of stones associated with abnormally low urinary levels of citrate—is waiting in the wings for approval. All three of these agents are classified as "orphan drugs"; that is, drugs needed by so few patients that most pharmaceutical companies will not go to the trouble and expense of ushering them through the FDA's approval procedures. In addition, the three agents suffer another disadvantage: Since they are standard chemical compounds, they cannot be patented. Thus, until the Orphan Drug Act became law earlier this year, a company that had obtained approval for such
Highlights of This Issue
Journal: Clinical Cancer Research (2015)

Inhibitors of the enzyme CYP17A1 such as abiraterone are initially effective in men with castration-resistant prostate cancer because they markedly decrease androgen synthesis, but upstream substrates, including progesterone, are increased. Chen and colleagues sequenced the androgen receptor (AR) in a series of tumor biopsies from men who developed resistance to CYP17A1 inhibitors and identified the T878A mutation, which confers responsiveness to alternative ligands, including progesterone, in 4 of 19 cases. These findings indicate that at least a subset of abiraterone-resistant tumors remain AR driven and identifies mutations that can exploit alternative ligands as a mechanism of resistance to abiraterone.Chemotherapy-induced cognitive impairment (CICI) has been recognized as a clinically significant problem in patients undergoing chemotherapy; however, little is known about the mechanisms and diagnostic measures of CICI. The phosphorylated form of the high-molecular-weight neurofilament heavy subunit NF-H (pNF-H), one of the major structural proteins in axon, has potential as an effective biomarker of neuronal damage. In this study, Natori and colleagues assessed serum pNF-H level in breast cancer patients treated with chemotherapy and found that it was increased in a cumulative dose-dependent manner, suggesting the potential application of pNF-H as a biomarker of neural damage after chemotherapy.Oncolytic viruses infect tumors cells while sparing normal tissues; however, efficacy of virotherapy in the clinic has been hindered by poor tumor targeting and intratumoral dissemination of oncolytic viruses. To tackle simultaneously these drawbacks, the authors present an oncolytic adenovirus, VCN-01, which combines a retargeting modification of the capsid with expression of the extracellular matrix-degrading enzyme hyaluronidase. The pRB-based replication selectivity of VCN-01 allows for a wide applicability in different tumor types. The reported favorable efficacy-toxicity preclinical profile supported two ongoing clinical trials of VCN-01, by intratumoral or intravenous administration, for the treatment of pancreatic cancer and other cancer types.K-Ras is the mostly widely dysregulated oncogene in non–small cell lung cancers, somatically point-mutated in ∼30% of adenocarcinomas. To assess the effect of Ras mutation status on prognostic markers for lung cancer, Starmans and colleagues designed targeted and permutation studies and compared biomarker accuracy in RAS-wildtype and RAS-mutant tumours. They find that RAS-mutant tumors are generally more difficult to prognose. Rather than creating a single prognostic biomarker, it is more effective to stratify patients by Ras-status and subject each group to an independent biomarker. These studies provide a template for integrated DNA and RNA biomarkers, as well as providing a new strategy for more accurately personalizing therapy in lung cancer.
Medical schools in the United States
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal