tbuckley/cabot-search huggingface dataset:
The Dutch Childhood Cancer Survivor Study (DCCSS)-LATER 2 kidney analysis examined long-term glomerular dysfunction in childhood cancer survivors
Authors: Esmee C.M. Kooijmans, Helena J.H. van der Pal, Saskia M.F. Pluijm, Margriet van der Heiden-van der Loo, Leontien C.M. Kremer, Dorine Bresters, Eline van Dulmen-den Broeder, Marry M. van den Heuvel-Eibrink, Jacqueline J. Loonen, Marloes Louwerens, Sebastian J.C. Neggers, Cécile Ronckers, Wim J.E. Tissing, Andrica C.H. de Vries, Gertjan J.L. Kaspers, Margreet A. Veening, Arend Bökenkamp
Journal: Kidney International (2022)

This investigation aimed to evaluate glomerular dysfunction among childhood cancer survivors in comparison with matched controls from the general population. In the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER 2 kidney analysis, a nationwide cross-sectional cohort study, 1024 survivors five or more years after diagnosis, aged 18 or more years at study, treated between 1963-2001 with nephrectomy, abdominal radiotherapy, total body irradiation, cisplatin, carboplatin, ifosfamide, high-dose cyclophosphamide or hematopoietic stem cell transplantation participated. In addition, 500 age- and sex-matched controls from Lifelines, a prospective population-based cohort study in the Netherlands, participated. At a median age of 32.0 years (interquartile range 26.6-37.4), the glomerular filtration rate was under 60 ml/min/1.73m2 in 3.7% of survivors and in none of the controls. Ten survivors had kidney failure. Chronic kidney disease according to age-thresholds (glomerular filtration rate respectively under 75 for age under 40, under 60 for ages 40-65, and under 40 for age over 65) was 6.6% in survivors vs. 0.2% in controls. Albuminuria (albumin-to-creatinine ratio over3 mg/mmol) was found in 16.2% of survivors and 1.2% of controls. Risk factors for chronic kidney disease, based on multivariable analyses, were nephrectomy (odds ratio 3.7 (95% Confidence interval 2.1-6.4)), abdominal radiotherapy (1.8 (1.1-2.9)), ifosfamide (2.9 (1.9-4.4)) and cisplatin over 500 mg/m2 (7.2 (3.4-15.2)). For albuminuria, risk factors were total body irradiation (2.3 (1.2-4.4)), abdominal radiotherapy over 30 Gy (2.6 (1.4- 5.0)) and ifosfamide (1.6 (1.0-2.4)). Hypertension and follow-up 30 or more years increased the risk for glomerular dysfunction. Thus, lifetime monitoring of glomerular function in survivors exposed to these identified high risk factors is warranted.
Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021
Authors: Laura C. Coates, Enrique R. Soriano, Nadia Corp, Heidi Bertheussen, Kristina Callis Duffin, Cristiano B. Campanholo, Jeffrey Chau, Lihi Eder, Daniel G. Fernández-Ávila, Oliver FitzGerald, Amit Garg, Dafna D. Gladman, Niti Goel, Philip S. Helliwell, M. Elaine Husni, Deepak R. Jadon, Arnon Katz, Dhruvkumar Laheru, John Latella, Ying-Ying Leung, Christine Lindsay, Ennio Lubrano, Luis Daniel Mazzuoccolo, Philip J. Mease, Denis O’Sullivan, Alexis Ogdie, Wendy Olsder, Penelope Esther Palominos, Lori Schick, Ingrid Steinkoenig, Maarten de Wit, D. A. van der Windt, Arthur Kavanaugh, Cristiano Campanholo, Oliver Fitzgerald, Dafna Gladman, Philip Helliwell, M. Elaine Husni, Dhrukumar Laheru, Ying-Ying Leung, Ennio Lubrano, Luis Daniel Mazzuoccolo, Philip J. Mease, Alexis Ogdie, Penelope Esther Palominos
Journal: Nature Reviews Rheumatology (2022)
OP0205-PARE GREEK RMDs PATIENTS’ NEED FOR SELF-MANAGEMENT AND THE USE OF NEW TECHNOLOGIES: THE CASE STUDY OF THE HELLENIC LEAGUE’S AGAINST RHEUMATISM SUPPORT LINE
Authors: N. Malliou, K. Antonopoulou
Journal: Annals of the Rheumatic Diseases (2022)

Background The Hellenic League Against Rheumatism (ELEANA/HELAR) offer psychosocial support to its member, patients with RMDs, their families and everyone else that’s interested in RMDs. More than 5000 members from all over Greece, with local ELEANA/HELAR groups in major cities such as Athens, Patras, Karditsa, Trikala, Thessaloniki and others. The helpline has been receiving incoming calls from patients with RMDs, members of ELEANA, their relatives and others that are interested in RMDs or are requesting information. Objectives This case study aimed at outlining that self-management is the main reason for incoming calls to ELEANA’s helpline and secondly that during the pandemic and even after lockdown measures being lifted patients still use the online support offered thus making it apparent that digitalization is not a trend anymore but a necessity. Methods Empirical data from the helpline were gathered through the day-to-day helpline registry. This is a detailed registry containing basic info on demographics of the callers, reasons for calling and outcome of communication. Descriptive statistics as well as qualitative data have been used such as observations of the trained staff of the helpline. Results From 543 incoming calls, 49,91% were about self-management and the rest 50,09% were calls requesting information. 52,40% of self-management calls were about psychological issues (anxiety, depressive symptoms) and the rest were about treatment (adherence), such as the use of medication, alternative treatments, medical issues and questions on RMDs. 40,96% of patients with RMDs called again the helpline to follow up and 61,25% used online tools to communicate with the helpline both times. Psychologists receiving calls observed that patients needed counseling regarding their self-management, especially during the pandemic and that even though lockdown is lifted they keep on requesting online communication instead of face-to-face meetings. Conclusion The above findings show that digitalization is not a trend rather than a necessity in the self-management of RMDs. Patients seem to find it easier receiving support online and the requests for online support for their anxiety, depressive symptoms, difficulties in managing their medication makes it clear that more emphasis needs to be put on self-management programs. Disclosure of Interests None declared
Three decades of ethical, legal, and social implications research: Looking back to chart a path forward
Authors: Deanne Dunbar Dolan, Sandra Soo-Jin Lee, Mildred K. Cho
Journal: Cell Genomics (2022)

More than thirty years ago in the United States, the National Center for Human Genome Research (NCHGR) at the National Institutes of Health (NIH) and its partner in the Human Genome Project (HGP), the Department of Energy (DOE), called for proposals from social scientists, ethicists, lawyers, and others to explore the ethical, legal, and social implications (ELSI) of mapping and sequencing the human genome. Today, nearly twenty years after the completion of the HGP, the ELSI Research Program of the National Human Genome Research Institute (NHGRI) continues this support. It has fostered the growth of ELSI research into a global field of study, uniquely positioned at the nexus of many academic disciplines and in proximity to basic and applied scientific research. We examine the formation of the first ELSI program and consider whether science policy in the public interest can exist within the confines of a set-aside from the NHGRI budget.
A novel scoring system using easily assessible predictors of return of spontaneous circulation and mortality in traumatic out-of-hospital cardiac arrest patients: A retrospective cohort study
Authors: I-Ming Kuo, Yi-Fu Chen, Chih-Ying Chien, Yi-Wen Hong, Shih-Ching Kang, Chih-Yuan Fu, Chih-Po Hsu, Chien-Hung Liao, Chi-Hsun Hsieh
Journal: International Journal of Surgery (2022)

An accident event may necessitate triage of multiple cases of traumatic out-of-hospital cardiac arrest (TOHCA). However, factors for prioritizing treatment among multiple TOHCA patients have not been established. This study aims to use easily assessible predictors of TOHCA outcomes to develop a triage scoring system.Patients with TOHCA brought to our hospital by emergency medical services (EMS) were included for analysis to identify independent risk factors for poor outcomes. A scoring system was developed and validated internally and externally.Of the 401 included patients, 86 (21.4%) had return of spontaneous circulation (ROSC) after cardiopulmonary resuscitation (CPR) for 30 min (81 patients, 94.2%) or 45 min (86 patients, 100%). The emergency department (ED) mortality rate was 89.3% and overall in-hospital mortality rate was 99%. Univariate and multivariate analyses identified body temperature <33 °C (OR, 4.65; 95% CI, 1.37-15.86), obvious chest injury (OR, 2.11; 95% CI, 1.03-4.34), and presumable etiology of out-of-hospital cardiac arrest (OR, 1.73; 95% CI, 1.01-2.98) as significant independent risk factors for non-ROSC. The TOHCA score, calculated as 1 point per risk factor, correlated significantly with the rate of non-ROSC and ED mortality (TOHCA score 0, 1, 2, 3: non-ROSC rate, 63.0%, 80.4%, 90.8%, 100%, respectively; ED mortality rate, 79.5%, 91.5%, 96.1%, and 100% respectively). The results of internal and external validations show a similar trend in both non-ROSC and mortality in the ED with increasing score.Termination of CPR for TOHCA after 45 min is reasonable; a 30-min resuscitation is acceptable in case of insufficient medical staff or resources. The TOHCA score may be able to be used with caution for triage.
Photosensitizer‐Polypeptide Conjugate for Effective Elimination of <i>Candida albicans</i> Biofilm
Authors: Pengqi Wan, Wei Guo, Yongjie Wang, Mingxiao Deng, Chunsheng Xiao, Xuesi Chen
Journal: Advanced Healthcare Materials (2022)

Persistent fungal infections caused by biofilms seriously endanger human health. In this study, a photosensitizer-polypeptide conjugate (PPa-cP) comprising a photosensitizer, pyropheophorbide a (PPa), and a cationic polypeptide (cP) is readily synthesized for effective antifungal and antibiofilm treatment. Compared with free PPa, the cationic PPa-cP shows enhanced binding ability to the negatively charged surface of Candida albicans (C. albicans) through electrostatic interactions. As a result, PPa-cP exhibits effective antifungal efficiency against both C. albicans and fluconazole-resistant C. albicans in vitro under light irradiation. The minimum inhibitory concentration (MIC) of PPa-cP for both C. albicans and fluconazole-resistant C. albicans is 1 µm. In addition, PPa-cP also shows improved penetration in a C. albicans biofilm, thus effectively eliminating the C. albicans biofilm by photodynamic effects. More importantly, PPa-cP demonstrats significantly enhanced therapeutic effects in a fluconazole-resistant C. albicans-infected rat model with minimal side effects. In conclusion, the current work presents an effective strategy to combat biofilm infections associated with biomedical equipment.
Enhancing self-management in type 1 diabetes with wearables and deep learning
Authors: Taiyu Zhu, Chukwuma Uduku, Kezhi Li, Pau Herrero, Nick Oliver, Pantelis Georgiou
Journal: npj Digital Medicine (2022)

People living with type 1 diabetes (T1D) require lifelong self-management to maintain glucose levels in a safe range. Failure to do so can lead to adverse glycemic events with short and long-term complications. Continuous glucose monitoring (CGM) is widely used in T1D self-management for real-time glucose measurements, while smartphone apps are adopted as basic electronic diaries, data visualization tools, and simple decision support tools for insulin dosing. Applying a mixed effects logistic regression analysis to the outcomes of a six-week longitudinal study in 12 T1D adults using CGM and a clinically validated wearable sensor wristband (NCT ID: NCT03643692), we identified several significant associations between physiological measurements and hypo- and hyperglycemic events measured an hour later. We proceeded to develop a new smartphone-based platform, ARISES (Adaptive, Real-time, and Intelligent System to Enhance Self-care), with an embedded deep learning algorithm utilizing multi-modal data from CGM, daily entries of meal and bolus insulin, and the sensor wristband to predict glucose levels and hypo- and hyperglycemia. For a 60-minute prediction horizon, the proposed algorithm achieved the average root mean square error (RMSE) of 35.28 ± 5.77 mg/dL with the Matthews correlation coefficients for detecting hypoglycemia and hyperglycemia of 0.56 ± 0.07 and 0.70 ± 0.05, respectively. The use of wristband data significantly reduced the RMSE by 2.25 mg/dL (p < 0.01). The well-trained model is implemented on the ARISES app to provide real-time decision support. These results indicate that the ARISES has great potential to mitigate the risk of severe complications and enhance self-management for people with T1D.
One-year safety and efficacy of tapinarof cream for the treatment of plaque psoriasis: Results from the PSOARING 3 trial
Authors: Bruce Strober, Linda Stein Gold, Robert Bissonnette, April W. Armstrong, Leon Kircik, Stephen K. Tyring, Stephen C. Piscitelli, Philip M. Brown, David S. Rubenstein, Anna M. Tallman, Mark G. Lebwohl
Journal: Journal of the American Academy of Dermatology (2022)
Planar‐/Curvilinear‐Bioprinted Tri‐Cell‐Laden Hydrogel for Healing Irregular Chronic Wounds
Authors: Shin‐Da Wu, Niann‐Tzyy Dai, Chao‐Yaug Liao, Lan‐Ya Kang, Yu‐Wen Tseng, Shan‐hui Hsu
Journal: Advanced Healthcare Materials (2022)

Abstract Chronic cutaneous wounds from tissue trauma or extensive burns can impair skin barrier function and cause severe infection. Fabrication of a customizable tissue‐engineered skin is a promising strategy for regeneration of uneven wounds. Herein, a planar‐/curvilinear‐bioprintable hydrogel is developed to produce tissue‐engineered skin and evaluated in rat models of chronic and irregular wounds. The hydrogel is composed of biodegradable polyurethane (PU) and gelatin. The hydrogel laden with cells displays good 3D printability and structure stability. The circular wounds of normal and diabetes mellitus (DM) rats treated with planar‐printed tri‐cell‐laden (fibroblasts, keratinocytes, and endothelial progenitor cells (EPCs)) hydrogel demonstrate full reepithelization and dermal repair as well as large amounts of neovascularization and collagen production after 28 days. Furthermore, the curvilinear module is fabricated based on the corresponding wound topography for curvilinear‐bioprinting of the irregular tissue‐engineered skin. The large and irregular rat skin wounds treated with curvilinear‐printed tri‐cell‐laden hydrogel demonstrate full repair after 28 days. This planar‐/curvilinear‐bioprintable tri‐cell‐laden hydrogel shows great potential for customized biofabrication in skin tissue engineering.
OP0239 REAL-LIFE SHORT-TERM EFFECTIVENESS OF ANTI-OSTEOPOROTIC TREATMENTS: A LONGITUDINAL COHORT STUDY
Authors: G. Adami, I. Gavioli, A. Fassio, C. Benini, E. Bertoldo, O. Viapiana, D. Gatti, M. Rossini
Journal: Annals of the Rheumatic Diseases (2022)

Background Data from randomized clinical trials showed that anti-osteoporotic treatments increase bone mineral density (BMD) and reduce the risk of fragility fractures. However, data on the real-life effectiveness of such medications is still scarce. Objectives The primary objective of the present study is to assess the real-life effectiveness of anti-osteoporotic treatment in a representative cohort of Italian women at high risk of fracture Methods We conducted a cohort study on women at high risk of fracture. We retrieved clinical and densitometric data from the DeFRA database, which derives from the DeFRA tool, a web-based fracture risk assessment tool. Multivariable Cox regression survival models were employed to analyze the effectiveness of different anti-osteoporotic drugs on fracture. In sensitivity analyses we generated 1:1 matched cohorts of patients with prescription of bisphosphonates, denosumab, teriparatide or without any pharmacological prescription at baseline and 1:1 matched cohort based on the T-score variation over the time (increase in T-score vs decrease or stability in T-score values). Results Data from 50,862 women were available. Among these, 3,574 individuals had at least 2 consecutive visits. The crude fracture rate was 91.9/1,000 person-year for non-treated patients. The crude fracture rate in bisphosphonate users was 72.1/1,000 person-year, in denosumab users was 58.2/1,000 person-year and in teriparatide users was 19.3/1000 person-year. Overall, we found that bisphosphonates were associated with a 30% lower risk of fracture compared to no treatment (aHR 0.70, 95% CI 0.50-0.98), denosumab and teriparatide were associated with 60% and 90% lower risk of fracture, respectively (aHR 0.43, 95% CI 0.24-0.75 and aHR 0.09, 95% CI 0.01-0.70). Bisphosphonate use was associated with a lower risk of fracture only after one year of treatment. In Figure 1 are presented the Kaplan Meier curves free from fragility fracture after propensity score matching. Conclusion In conclusion, we found that all anti-osteoporotic medications effectively reduced the risk of fracture in the real-life. Bisphosphonate’s effect on fracture risk was apparent only after the first year of treatment. Our findings do not support the use of bisphosphonates in patients at imminent risk of fracture. Disclosure of Interests Giovanni Adami Shareholder of: Theramex, Galapagos, IRENE GAVIOLI: None declared, Angelo Fassio: None declared, Camilla Benini: None declared, Eugenia Bertoldo: None declared, Ombretta Viapiana: None declared, Davide Gatti: None declared, Maurizio Rossini Shareholder of: Abbvie, Amgen, Bms, Eli Lilly, Galapagos, Novartis, Pfizer, Sandoz, Theramex, Ucb.
Overturning Roe v Wade: reproducing injustice
Authors: Nina Sun
Journal: BMJ (2022)

reproducing injusticeWhile the impact of overturning Roe will be most acutely felt in the US, its repercussions will be felt globally, writes Nina Sun Nina Sun, On Friday 24 June, the US Supreme Court dealt a devastating blow to reproductive justice.In Dobbs v. Jackson, the Supreme Court reversed Roe v. Wade, which guaranteed women and pregnant people a constitutional right to abortion.In doing so, the Court turned its back to medical evidence, public health, and human rights.Access to abortion is now under the purview of individual states and governed by a patchwork of abortion laws, with some states banning abortion in all instances.
Clinical, phenotypic and genetic landscape of case reports with genetically proven inherited disorders of vitamin B12 metabolism: A meta-analysis
Authors: Arnaud Wiedemann, Abderrahim Oussalah, Nathalie Lamireau, Maurane Théron, Melissa Julien, Jean-Philippe Mergnac, Baptiste Augay, Pauline Deniaud, Tom Alix, Marine Frayssinoux, François Feillet, Jean-Louis Guéant
Journal: Cell Reports Medicine (2022)

Inherited disorders of B12 metabolism produce a broad spectrum of manifestations, with limited knowledge of the influence of age and the function of related genes. We report a meta-analysis on 824 patients with a genetically proven diagnosis of an inherited disorder of vitamin B12 metabolism. Gene clusters and age categories are associated with patients' manifestations. The "cytoplasmic transport" cluster is associated with neurological and ophthalmological manifestations, the "mitochondrion" cluster with hypotonia, acute metabolic decompensation, and death, and the "B12 availability" and "remethylation" clusters with anemia and cytopenia. Hypotonia, EEG abnormalities, nystagmus, and strabismus are predominant in the younger patients, while neurological manifestations, such as walking difficulties, peripheral neuropathy, pyramidal syndrome, cerebral atrophy, psychiatric disorders, and thromboembolic manifestations, are predominant in the older patients. These results should prompt systematic checking of markers of vitamin B12 status, including homocysteine and methylmalonic acid, when usual causes of these manifestations are discarded in adult patients.
Prebiotic-like cyclodextrin assisted silybin on NAFLD through restoring liver and gut homeostasis
Authors: Ling Ren, Xiao-Lei Ma, Hong-Liang Wang, Rui Li, Jin-Jin Cui, Peng-Ju Yan, Ya-Nan Wang, Xiao-You Yu, Peng Du, Hao-Yang Yu, Hui-Hui Guo, Rou Tang, Yong-Sheng Che, Wen-Sheng Zheng, Jian-Dong Jiang, Lu-Lu Wang
Journal: Journal of Controlled Release (2022)
Phase III Randomized Trial of Maintenance Taxanes Versus Surveillance in Women With Advanced Ovarian/Tubal/Peritoneal Cancer: A Gynecologic Oncology Group 0212:NRG Oncology Study
Authors: Larry J. Copeland, Mark F. Brady, Robert A. Burger, William H. Rodgers, Helen Q. Huang, David Cella, David M. O'Malley, Daron G. Street, Krishnansu S. Tewari, David P. Bender, Robert T. Morris, William J. Lowery, David S. Miller, Summer B. Dewdney, Nick M. Spirtos, Shashikant B. Lele, Saketh Guntupalli, Frederick R. Ueland, Gretchen E. Glaser, Robert S. Mannel, Philip J. DiSaia
Journal: Journal of Clinical Oncology (2022)

To compare taxane maintenance chemotherapy, paclitaxel (P) and paclitaxel poliglumex (PP), with surveillance (S) in women with ovarian, peritoneal, or fallopian tube (O/PC/FT) cancer who attained clinical complete response after first-line platinum-taxane therapy.Women diagnosed with O/PC/FT cancer who attained clinical complete response after first-line platinum-taxane-based chemotherapy were randomly allocated 1:1:1 to S or maintenance, P 135 mg/m2 once every 28 days for 12 cycles, or PP at the same dose and schedule. Overall survival (OS) was the primary efficacy end point.Between March 2005 and January 2014, 1,157 individuals were enrolled. Grade 2 or worse GI adverse events were more frequent among those treated with taxane (PP: 20%, P: 27% v S: 11%). Grade 2 or worse neurologic adverse events occurred more often with taxane treatment (PP: 46%, P: 36% v S: 14%). At the fourth scheduled interim analysis, both taxane regimens passed the OS futility boundary and the Data Monitoring Committee approved an early release of results. With a median follow-up of 8.1 years, 653 deaths were reported; none were attributed to the study treatment. Median survival durations were 58.3, 56.8, and 60.0 months for S, P, and PP, respectively. Relative to S, the hazard of death for P was 1.091 (95% CI, 0.911 to 1.31; P = .343) and for PP, it was 1.033 (95% CI, 0.862 to 1.24; P = .725). The median times to first progression or death (PFS) were 13.4, 18.9, and 16.3 months for S, P, and PP, respectively. Hazard ratio = 0.801; 95% CI, 0.684 to 0.938; P = .006 for P and hazard ratio = 0.854; 95% CI, 0.729 to 1.00; P = .055 for PP.Maintenance therapy with P and PP did not improve OS among patients with newly diagnosed O/tubal/peritoneal cancer, but may modestly increase PFS. GI and neurologic toxicities were more frequent in the taxane treatment arms.