GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors
Authors: Anna R. Docherty, Niamh Mullins, Allison E. Ashley-Koch, Xuejun Qin, Jonathan R.I. Coleman, Andrey Shabalin, JooEun Kang, Balasz Murnyak, Frank Wendt, Mark Adams, Adrian I. Campos, Emily DiBlasi, Janice M. Fullerton, Henry R. Kranzler, Amanda V. Bakian, Eric T. Monson, Miguel E. Rentería, Consuelo Walss-Bass, Ole A. Andreassen, Chittaranjan Behera, Cynthia M. Bulik, Howard J. Edenberg, Ronald C. Kessler, J. John Mann, John I. Nurnberger, Giorgio Pistis, Fabian Streit, Robert J. Ursano, Renato Polimanti, Michelle Dennis, Melanie Garrett, Lauren Hair, Philip Harvey, Elizabeth R. Hauser, Michael A. Hauser, Jennifer Huffman, Daniel Jacobson, Ravi Madduri, Benjamin McMahon, David W. Oslin, Jodie Trafton, Swapnil Awasthi, Wade H. Berrettini, Martin Bohus, Xiao Chang, Hsi-Chung Chen, Wei J. Chen, Erik D. Christensen, Scott Crow, Philibert Duriez, Alexis C. Edwards, Fernando Fernández-Aranda, Hanga Galfalvy, Michael Gandal, Philip Gorwood, Yiran Guo, Jonathan D. Hafferty, Hakon Hakonarson, Katherine A. Halmi, Akitoyo Hishimoto, Sonia Jain, Stéphane Jamain, Susana Jiménez-Murcia, Craig Johnson, Allan S. Kaplan, Walter H. Kaye, Pamela K. Keel, James L. Kennedy, Minsoo Kim, Kelly L. Klump, Daniel F. Levey, Dong Li, Shih-Cheng Liao, Klaus Lieb, Lisa Lilenfeld, Christian R. Marshall, James E. Mitchell, Satoshi Okazaki, Ikuo Otsuka, Dalila Pinto, Abigail Powers, Nicolas Ramoz, Stephan Ripke, Stefan Roepke, Vsevolod Rozanov, Stephen W. Scherer, Christian Schmahl, Marcus Sokolowski, Anna Starnawska, Michael Strober, Mei-Hsin Su, Laura M. Thornton, Janet Treasure, Erin B. Ware, Hunna J. Watson, Stephanie H. Witt, D. Blake Woodside, Zeynep Yilmaz, Lea Zillich, Rolf Adolfsson, Ingrid Agartz, Martin Alda, Lars Alfredsson, Vivek Appadurai, María Soler Artigas, Sandra Van der Auwera, M. Helena Azevedo, Nicholas Bass, Claiton H.D. Bau, Bernhard T. Baune, Frank Bellivier, Klaus Berger, Joanna M. Biernacka, Tim B. Bigdeli, Elisabeth B. Binder, Michael Boehnke, Marco P. Boks, David L. Braff, Richard Bryant, Monika Budde, Enda M. Byrne, Wiepke Cahn, Enrique Castelao, Jorge A. Cervilla, Boris Chaumette, Aiden Corvin, Nicholas Craddock, Srdjan Djurovic, Jerome C. Foo, Andreas J. Forstner, Mark Frye, Justine M. Gatt, Ina Giegling, Hans J. Grabe, Melissa J. Green, Eugenio H. Grevet, Maria Grigoroiu-Serbanescu, Blanca Gutierrez, Jose Guzman-Parra, Marian L. Hamshere, Annette M. Hartmann, Joanna Hauser, Stefanie Heilmann-Heimbach, Per Hoffmann, Marcus Ising, Ian Jones, Lisa A. Jones, Lina Jonsson, René S. Kahn, John R. Kelsoe, Kenneth S. Kendler, Stefan Kloiber, Karestan C. Koenen, Manolis Kogevinas, Marie-Odile Krebs, Mikael Landén, Marion Leboyer, Phil H. Lee, Douglas F. Levinson, Calwing Liao, Jolanta Lissowska, Fermin Mayoral, Susan L. McElroy, Patrick McGrath, Peter McGuffin, Andrew McQuillin, Divya Mehta, Ingrid Melle, Philip B. Mitchell, Esther Molina, Gunnar Morken, Caroline Nievergelt, Markus M. Nöthen, Michael C. O’Donovan, Roel A. Ophoff, Michael J. Owen, Carlos Pato, Michele T. Pato, Brenda W.J.H. Penninx, James B. Potash, Robert A. Power, Martin Preisig, Digby Quested, Josep Antoni Ramos-Quiroga, Andreas Reif, Marta Ribasés, Vanesa Richarte, Marcella Rietschel, Margarita Rivera, Andrea Roberts, Gloria Roberts, Guy A. Rouleau, Diego L. Rovaris, Alan R. Sanders, Peter R. Schofield, Thomas G. Schulze, Laura J. Scott, Alessandro Serretti, Jianxin Shi, Lea Sirignano, Pamela Sklar, Olav B. Smeland, Jordan W. Smoller, Edmund J.S. Sonuga-Barke, Maciej Trzaskowski, Ming T. Tsuang, Gustavo Turecki, Laura Vilar-Ribó, John B. Vincent, Henry Völzke, James T.R. Walters, Cynthia Shannon Weickert, Thomas W. Weickert, Myrna M. Weissman, Leanne M. Williams, Naomi R. Wray, Clement C. Zai, Esben Agerbo, Anders D. Børglum, Gerome Breen, Ditte Demontis, Annette Erlangsen, Joel Gelernter, Stephen J. Glatt, David M. Hougaard, Hai-Gwo Hwu, Po-Hsiu Kuo, Cathryn M. Lewis, Qingqin S. Li, Chih-Min Liu, Nicholas G. Martin, Andrew M. McIntosh, Sarah E. Medland, Ole Mors, Merete Nordentoft, Catherine M. Olsen, David Porteous, Daniel J. Smith, Eli A. Stahl, Murray B. Stein, Danuta Wasserman, Thomas Werge, David C. Whiteman, Virginia Willour, Hilary Coon, Jean C. Beckham, Nathan A. Kimbrel, Douglas M. Ruderfer
Journal: American Journal of Psychiatry (2023)

Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The present study leveraged the genetic cohorts from both studies to conduct the largest GWAS meta-analysis of SA to date. Multi-ancestry and admixture-specific meta-analyses were conducted within groups of significant African, East Asian, and European ancestry admixtures.