POS0907 ASSOCIATION BETWEEN DISEASE ACTIVITY AND DAMAGE IN IDIOPATHIC INFLAMMATORY MYOPATHIES. DIFFERENCES BETWEEN INCIDENT AND PREVALENT CASES
Authors: T. Cobo-Ibáñez, D. Seoane-Mato, I. Carrión Barberà, I. Castellví, L. Nuño, J. Martínez-Barrio, V. Jovani, F. Romero Bueno, E. Ruiz Lucea, E. Tomero Muriel, E. Trallero-Araguás, J. Narváez, J. Camins Fabregas, A. Ruiz Román, J. Loarce-Martos, S. Holgado, D. F. Esmeralda, F. Sivera, C. Merino Argumánez, A. J. Mas, J. L. Tandaipan, C. Plasencia, A. Gomez-Gomez, O. Sanchez Pernaute, J. M. Pego-Reigosa, B. Joven-Ibáñez, J. Belzunegui, C. Carrasco-Cubero, M. Freire González, E. Naveda, N. Lozano Rivas, J. D. Suarez Cuba, O. Martínez González, R. Ortega Castro, P. Alcocer-Amores
Journal: Annals of the Rheumatic Diseases (2022)

Background There are different measures and tools validated to evaluate disease activity and damage in idiopathic inflammatory myopathies (IIM). Disease activity and damage in patients with early diagnosis is not still well defined. Objectives To analyze disease activity outcomes and their association with damage in IIM differentiating between incident and prevalent cases. Methods Multicenter cross-sectional study of a cohort of patients included in the Spanish Registry of patients with IIM (Myo-Spain)(1). Patients were classified as incident cohort (time between diagnosis and study initiation ≤ 12 months) or prevalent cohort (&gt; 12 months). Activity and damage data were collected at the initial visit. Differences between both groups were tested by Chi-square, Student’s t and Mann-Whitney tests. Spearman’s correlation coefficients (Rho) were used to analyze correlations between disease activity and damage measures (weak ≥ 0.2 - &lt;0.3; moderate ≥ 0.3 &lt;0.7; strong ≥ 0.7). Results We included 139 (67.63% women) and 417 patients (74.34% women) with a mean age at diagnosis of 54 and 48 years in the incident and prevalent cohort, respectively. Patients in the incident cohort had significantly higher disease activity measures: myositis disease activity assessment visual analogue scale (MYOACT) total, extramuscular activity of MYOACT, physician global activity (PhGA), patient global activity (PGA), manual muscle testing (MMT)8, CK, and HAQ (p &lt; 0.001).The organ systems with the bigger differences between the incident and the prevalent cohort were skin and constitutional (p&lt;0.001). No significant differences were found respect to physician global damage (PhGD), patient global damage (PGD) and myositis damage index (MDI), between both cohorts (p &gt; 0.2). Correlations between disease activity and damage measures are showed in the Table 1. The main differences found between both cohorts were the correlations of PhGA, CK, PGD and MDI with other measures of disease activity. Table 1. Correlations between disease activity and damage measures Incident cohort Prevalent cohort MYOACT total Extramuscular activity of MYOACT PhGA MMT- 8 MYOACT total Extramuscular activity of MYOACT PhGA MMT- 8 Extramuscular activity of MYOACT Rho 0.76 1 0.673 -0.166 0.777 1 0.764 -0.214 P-value &lt;0.001 &lt;0.001 &lt;0.001 0.065 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 PhGA Rho 0.823 0.673 1 -0.5 0.779 0.764 1 -0.301 P-value &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 PGA Rho 0.667 0.544 0.679 -0.434 0.585 0.528 0.623 -0.345 P-value &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 MMT-8 Rho -0.471 -0.166 -0.5 1 -0.383 -0.214 -0.301 1 P-value &lt;0.001 0.065 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 CK Rho 0.221 -0.086 0.234 -0.438 0.07 -0.024 0.112 -0.11 P-value 0.014 0.351 0.008 &lt;0.001 0.178 0.648 0.029 0.034 HAQ Rho 0.486 0.338 0.528 -0.49 0.386 0.248 0.384 -0.505 P-value &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 PhGD Rho 0.367 0.31 0.448 -0.305 0.573 0.492 0.598 -0.334 P-value &lt;0.001 0.001 &lt;0.001 0.001 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 PGD Rho 0.293 0.163 0.354 -0.295 0.468 0.408 0.476 -0.347 P-value 0.003 0.102 &lt;0.001 0.002 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 MDI Rho 0.398 0.279 0.388 -0.232 0.579 0.477 0.545 -0.343 P-value &lt;0.001 0.006 &lt;0.001 0.026 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 Myositis disease activity assessment visual analogue scale (MYOACT), physician global activity (PhGA), patient globalactivity (PGA), manual muscle testing (MMT)8, health assessment questionnaire (HAQ), physician global damage(PhGD), patient global damage (PGD), myositis damage index (MDI). Conclusion Incident cases had higher disease activity. In those in whom damage was detected, no differences were found in damage measures with prevalent cases. The correlation between the different measures of activity and damage was slightly better in prevalent patients. References [1]Cobo-Ibáñez T, et al. Myo-Spain: Spanish Registry of patients with idiopathic inflammatory myopathy. Methodology. Reumatol Clin (Engl Ed). 2021 Aug 13:S2173-5743(21)00156-8. Acknowledgements To Nuria Montero for her contribution to data monitoring, and Francisco Javier Prado-Galbarro for his contribution to data analysis. Disclosure of Interests None declared