tbuckley/cabot-search huggingface dataset:
Restrictions on Family Presence in the ICU
Authors: Richard J Brilli
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Paper-Chase
Authors: Robert Hogan
Journal: JAMA (1991)

Fifteen years ago, medical students who were pursuing a piece of information went to the medical library to "look it up," generally beginning with a recent text and proceeding to<i>Index Medicus</i>with pencil and paper in hand. One then walked with a few selected citations into the stacks and either read the articles on the spot or trundled off to the copy machine with the intention of reading the treasured finds soon thereafter. This process is undoubtedly still repeated in the stacks of biomedical libraries at medical schools around the world. This literal "going to the literature" was (and is) tedious but rewarding but, for most of the present generation of practicing physicians, is likely to have diminished. Who can set aside the hours needed for travel to a good library, the slow browsing, the meandering through citations? Therein lies a central source of displeasure with medical practice: we
Hepatic expression of c-Myb in chronic human liver disease
Authors: T Kitada, S Seki, K Nakatani, N Kawada, T Kuroki, T Monna
Journal: Hepatology (1997)

C-Myb is a sequence-specific DNA binding protein that regulates the expression of genes involved in cell proliferation and differentiation. The present study was designed to elucidate the role of c-Myb in the pathogenesis of chronic liver disease by an immunohistochemical approach. In normal (control) livers, few or no hepatic cells were positive for c-Myb. In livers from patients with chronic viral hepatitis, positive staining for c-Myb was found not only in spindle-shaped mesenchymal cells in expanded portal areas, but also in perisinusoidal cells (PSCs) within liver lobules. In cirrhotic livers, a few PSCs within lobules were positive for c-Myb, while no staining was seen in fibrous septa. Immunoelectron microscopy revealed that c-Myb-positive PSCs displayed morphological features of hepatic stellate cells. Other sinusoidal lining cells including Kupffer cells and sinusoidal endothelial cells, as well as hepatocytes, were all negative for c-Myb. Dual c-Myb/α-smooth muscle actin (αSMA) staining revealed that more than 97% of c-Myb-positive cells were αSMA-positive. Moreover, dual c-Myb/proliferating cell nuclear antigen (PCNA) staining showed that approximately 70% of c-Myb-positive cells also expressed PCNA. The labeling index (LI) (number of c-Myb-positive cells/0.1 mm 2 ) significantly correlated with serum transaminase concentrations and increased in parallel with the disease activity. However, the LI showed no correlation with the degree of fibrosis. These results suggest that c-Myb may be involved in stellate cell activation and proliferation in chronically diseased human livers, and that the level of c-Myb expression is associated with the activity of chronic hepatitis.
Foreword
Authors: Robin Graham-Brown
Journal: British Journal of Dermatology (2002)

Journal Article Foreword Get access Robin Graham‐Brown Robin Graham‐Brown Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 147, Issue s62, 1 July 2002, Page v, https://doi.org/10.1046/j.1365-2133.147.s62.11.x Published: 01 July 2002
A Phase II Study of Modified Lenalidomide, Bortezomib, and Dexamethasone (RVD-lite) for Transplant-Ineligible Patients with Newly Diagnosed Multiple Myeloma
Authors: Elizabeth K. O'Donnell, Jacob P. Laubach, Andrew J. Yee, Carol A. Huff, Frank G. Basile, Philip M. Wade, Claudia E. Paba-Prada, Irene M. Ghobrial, Robert L. Schlossman, Nicole R. Couture, Lauren Doherty, Hannah Lyons, Caroline English, Nikhil C. Munshi, Kenneth C. Anderson, Paul G. Richardson, Noopur S. Raje
Journal: Blood (2015)
Bacterial Growth with Chlorinated Methanes
Authors: Thomas Leisinger, Susanna A. Braus-Stromeyer
Journal: Environmental Health Perspectives (1995)

Chlorinated methanes are important industrial chemicals and significant environmental pollutants.While the highly chlorinated methanes, trichloromethane and tetrachloromethane, are not productively metabolized by bacteria, chloromethane and dichloromethane are used by both aero- bic and anaerobic methylotrophic bacteria as carbon and energy sources.Some of the dehalogenation reactions involved in the utilization of the latter two compounds have been elucidated.In a strictly anaerobic acetogenic bacterium growing with chloromethane, an inducible enzyme forming methyltetrahydrofolate and chloride from chloromethane and tetrahydrofolate catalyzes dehalogenation of the growth substrate.A different mecha- nism for the nucleophilic displacement of chloride is observed in aerobic methylotrophic bacteria utilizing dichloromethane as the sole carbon and energy source.These organisms possess the enzyme dichloromethane dehalogenase which, in a glutathione-dependent reaction, converts dichloromethane to inorganic chloride and formaldehyde, a central metabolite of methylotrophic growth.Sequence comparisons have shown that bacterial dichloromethane dehalogenases belong to the glutathione S-transferase enzyme family, and within this family to class Theta.The dehalo- genation ractions underlying aerobic utilization of chloromethane by a pure culture and anaerobic growth with dichloromethane by an acetogenic mixed culture are not known.It appears that they are based on mechanisms other than nucleophilic attack by tetrahydrofolate or glutathione.
Zinc supplementation and amino acid-nitrogen metabolism in patients with advanced cirrhosis
Authors: G Marchesini, A Fabbri, G Bianchi, M Brizi, M Zoli
Journal: Hepatology (1996)

Zinc deficiency is common in cirrhosis and has been involved in the altered nitrogen metabolism. In this study, we measured the effects of zinc supplementation on the dynamics of amino acid-derived urea synthesis in cirrhosis with mild or latent encephalopathy. The hepatic conversion of amino acids into urea was studied in eight patients with advanced cirrhosis under controlled conditions of substrate availability (continuous alanine infusion), before and after 3-month oral zinc sulfate supplementation (600 mg/d). Eight more patients, matched for hepatocellular failure and encephalopathy, served as controls. Plasma zinc levels were reduced in all patients and returned to normal after oral zinc. The alanine-stimulated urea nitrogen synthesis rate in relation to α-amino-N concentration-the functional hepatic nitrogen clearance-increased by 25% after zinc supplementation, i.e., more urea was produced at any α-amino-N concentration. Basal and alanine-induced glucagon decreased by 50%, and the ammonia response to alanine decreased by 30%. Psychometric tests improved, as did routine and dynamic liver function tests and the Child- Pugh score. Also, the plasma concentration of lipid peroxides was reduced by zinc. No significant changes were observed in the control group. Our data indicate that long-term oral zinc speeds up the kinetics of urea formation from amino acids and ammonia. Changes in the hormonal drive and/or the antioxidant activity of zinc might be involved in the general improvement in liver function, whereas the beneficial effects on encephalopathy might stem from decreased ammonia.
Next-generation human genetics
Authors: Jay Shendure
Journal: Genome biology (2011)

Deep exome resequencing is a powerful approach for delineating patterns of protein-coding variation among genes, pathways, individuals and populations.We analyzed exome data from 2,440 individuals of European and African ancestry as part of the National Heart, Lung, and Blood Institute's Exome Project, the aim of which is to discover novel genes and mechanisms that contribute to heart, lung and blood disorders.Each exome was sequenced to a mean coverage of 116×, allowing detailed inferences about the population genomic patterns of both common variation and rare coding variation.We identifi ed more than 500,000 single nucleotide variations, the majority of which were novel and rare (76% of variants had a minor allele frequency of less than 0.1%), refl ecting the recent dramatic increase in the size of the human population.The unprecedented magnitude of this dataset allowed us to rigorously characterize the large variation in nucleotide diversity among genes (ranging from 0 to 1.32%), as well as the role of positive and purifying selection in shaping patterns of proteincoding variation and the diff erential signatures of population structure from rare and common variation.This dataset provides a framework for personal genomics and is an important resource that will allow inferences of broad importance to human evolution and health.
Primary Chylopericardium
Authors: Laurence K. Groves, Donald B. Effler
Journal: New England Journal of Medicine (1954)

EFFUSION of chyle into various body cavities is an interesting and uncommon clinical phenomenon. In spite of its infrequent occurrence the management of chylous effusion has stimulated a number of excellent articles.1 2 3 Since the greatest portion of the chyle vascular system courses through the chest via the thoracic duct it is not surprising that chyle most often extravasates into the pleural cavities.Chylopericardium is particularly uncommon; we have found only 6 case reports in which chyle appeared in the pericardial sac, and in each there was associated massive chylothorax.1 , 4 , 5 Primary chylopericardium unrelated to trauma must be of unusual rarity; we . . .
THE RETICULOSES*
Authors: W. N. GOLDSMITH
Journal: British Journal of Dermatology (1944)

Journal Article THE RETICULOSES Get access W. N. GOLDSMITH W. N. GOLDSMITH Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 56, Issue 5-6, 1 May 1944, Pages 107–128, https://doi.org/10.1111/j.1365-2133.1944.tb10833.x Published: 01 May 1944
Depression
Authors: Robert M. McCarron, Erik R. Vanderlip, Jeffrey Rado
Journal: Annals of Internal Medicine (2016)

This issue provides a clinical overview of depression, focusing on screening, diagnosis, treatment, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers.
THE DIETARY HABITS OF AMERICAN COLLEGE GIRLS
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: S Tada, M Iida
Journal: Gut (1994)

Lettersfind such a good correlation between motility and ulcer pain8 9 and although in our own studies the use of an anti-spasmodic did not affect the development of acid induced duodenal ulcer pain,6 we feel that duodenal wall tension or dysmotility deserve further study as a possible cause of duodenal ulcer pain and a possible explanation for the imperfect correla- tion between the pH around the ulcer crater and development of ulcer pain in patients with symptomatic duodenal ulcer.
The Role of Medicine Within a Business Organization
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bacteria in Daily Life.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bone density changes during adjuvant aromatase inhibitor treatment in breast cancer patients: Single center experience
Authors: M. Almatari, M. Moe, P. Ali, P. Willshaw
Journal: Journal of Clinical Oncology (2009)

e11565 Background: Adjuvant aromatase inhibitors (AI) therapy in breast cancer accelerates bone loss resulting in increased incidence of fracture. We evaluated the effect of AI on bone density changes among breast cancer patients. Method: A total of 85 patients who had adjuvant AI for more than 24 months and 3 Dual energy X-ray Absorptiometry (DXA) scans were included in this study. Annual bone density change was calculated and correlated with various risk and prognostic factors. Results: Adjuvant AI was given in up-front (50), sequential (15) and extended adjuvant (17) therapy settings, with a median duration of 31 months. Intervals between scans varied from 6 - 33 months (median = 13 months), 63 patients had baseline DXA scans undertaken within 6 months from start of AI. Bisphosphonate was prescribed to 35 patients during AI therapy according to local practice. Changes in bone density according to WHO classification is shown in the table. Annual bone density change in the spine at 2 nd scan was (-9.2% to +11%, mean = -0.89±4.11), after 3 rd scan, (-11.7% to +10.7%, mean = 0.021±3.84). In the group of patients who had adjuvant chemotherapy (59 patients), significant bone loss was seen in the patients who did not have bisphosphonate (n=39), (-0.011 in BMD, Mean=0.88±0.02) compared to those who had bisphosphonate (n=20), (0.036 in BMD, Mean=0.93±0.02). In the patients who did not have chemotherapy (n=26), no bone loss was seen whether bisphosphonate was used or not. No clinical bone fracture was reported among patients who had osteoporosis at baseline. Conclusions: The patients who had chemotherapy are more likely to lose bone density and close monitoring is required for bisphosphonate therapy. Bone loss is more significant in the lumbar spine compared to the hip. Following intervention with bisphosphonate, the rate of bone loss was reduced, and as a result only 2.3% of patients developed osteoporosis during AI treatment. AI can be safely given from the bone health point of view with the appropriate use of bisphosphonate. [Table: see text] No significant financial relationships to disclose.
Abortion: A Special Demand
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adolescent Pregnancy
Authors: J. Thomas Fitch
Journal: JAMA (1996)

<h3>To the Editor.</h3> —We are confident that Dr Litt's Editorial<sup>1</sup>was written with good intentions and that she believes her 3 proposed interventions will decrease adolescent pregnancy and STD. However, they have been tried, and they have failed. Litt's first proposal concerns postponing "initiation of sexual experimentation until psychosocial maturity guides protective behaviors." We are unsure what "psychosocial maturity" means. However, most parents we talk with believe their adolescent children, regardless of age, have not quite "arrived." Two recent studies show that even in stable heterosexual relationships with 1 human immunodeficiency virus (HIV)-infected partner, only 50% of the couples used condoms consistently and correctly, despite being informed of risks.<sup>2,3</sup>Will adolescents, who do not know the HIV status of their partners and who have a propensity for taking risks, achieve better results? Second, Litt proposes that adolescents receive counseling about methods of pregnancy and STD protection prior to first intercourse experience.
Imported Dengue—United States, 1992
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elemental Analysis of Renal Slices by Proton-Induced X-Ray Emission
Authors: Timothy Lowe, Quan Chen, Quintus Fernando, Rodney Keith, A. Jay Gandolfi
Journal: Environmental Health Perspectives (1993)

We optimized proton-induced X-ray emission (PIXE) for tissue analysis in a toxicity-disposition study. We used cultured rabbit renal slices as the biological system to demonstrate the use of PIXE analysis. The renal slices were exposed to HgCl2, CdCl2, K2Cr2O7, or NaAsO2 alone or in a mixture. The PIXE analysis provides information on concentrations of elements above atomic number 11, and it is the only analytical technique that can determine 20-30 elements nondestructively in a single, small sample (approximately 5 mg) with detection limits of 1-5 ppm (dry weight). The renal slices are thin targets that yield X-ray emission spectra with low backgrounds and high elemental sensitivities. The nondestructive nature of PIXE and the ability to simultaneously measure uptake of multiple metals and endogenous elements are unique to this methodology.
A Correction
Authors: George Henty, C Aveling, Welcomed.-E Powell, J Ogilvie Will, C Thisel- 'i'on Urquhart, Drs Leslie, Ronald Skeen, Lewis Smythe
Journal: BMJ (1892)

NORTa LONDON DrsTaICT.-Thean- 'M11al meeting of this District, which comprises North London and North-West Districts, for the election of officers and committee, will be held at the Holborn Restaurant at 6.30 P.x