tbuckley/cabot-search huggingface dataset:
The unrelenting epidemic of violence in America. Truths and consequences
Authors: P. B. Fontanarosa
Journal: JAMA (1995)

Three years ago, violence in America was declared a public health emergency.<sup>1</sup>Since that time, the urgency of reducing death and disability caused by the national epidemic of violence has not diminished. The morbidity and mortality resulting from interpersonal violence have been unrelenting, have continued to increase, and have been punctuated by widely publicized acute exacerbations. The tragic bombing in Oklahoma City and the Simpson murder trial serve as grim reminders of both the pervasiveness of violence in US society and the potential vulnerability of all US citizens to acts of violence. This issue ofThe Journalcontains a collection of articles presenting new research on interpersonal violence. Among the studies are updated reports on firearm-related injuries and deaths, unique findings on factors associated with intraracial homicides and weapon involvement in home invasion crimes, and clinically relevant current information on domestic violence against women. Taken together, these articles provide
History, Brain
Authors: Otniel E. Dror
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spatial Vectorcardiography
Authors: L. Wolff, J. L. Richman, A. M. Soffe
Journal: New England Journal of Medicine (1953)

Myocardial InfarctionThe vectors of depolarization point from endocardium to epicardium in reference systems having a positive polarity, and in the reverse direction if the polarity is negative. The discussion in this and the following sections refers to systems of positive polarity, as used in this laboratory, but is applicable to the opposite polarity by a reversal of the direction of the vectors.Each point on the QRS loop is the terminus of a resultant of numerous component vectors, contributed by all muscle elements undergoing depolarization at that instant. Infarction of some of these elements renders them electrically inert, and . . .
Correction
Journal: BMJ (1963)

ANY QUESTIONS ?M RMICALJOURNAL sac behind, so that poison continues to be injected for several seconds by muscular action.The sting should be removed first but not by picking it out.It should be scraped out with a finger nail or wiped out with a handkerchief.Often the victim, however, is too hopping mad to do either of these things.For an excellent account of the treat- ment of bee-sting reactions the reader is referred to an article by Dr. A. W. Franklin.2There is a vast literature on bee venom and a full list of references is given in Bee World.3The components of bee venom are described by N. B. Hodgson.'
Stat Bite: Breast Cancer Incidence by Race/Ethnicity
Journal: JNCI Journal of the National Cancer Institute (1996)

News NewsFor use in a vaccine, investigators intend to pair IL-12 with a specific tumor antigen as an immune system booster.That is the strategy employed in a vaccine trial involving melanoma now under way at several sites.The principal investigator for the trial is Steven A. Rosenberg, M.D., Ph.D., chief of NCI's Surgery Branch.IL-12 is coupled to an antigen for the MART-1 peptide (which stands for Melanoma Antigen Recognized by Tcells-1), which is an effective antigen only in individuals expressing a common immune marker known as HLA-A2.The vaccine mixture is then administered through a series of inoculations at varying doses.Altogether, only a handful of patients are enrolled so far.
Krankheiten und Hygiene der warmen Länder: Ein Lehrbuch für die Praxis.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Authors: Nicola Principi, Susanna Esposito
Journal: Thorax (2011)

conditioning replacement has probably been overestimated because the emergence of the new 19A serotype has also been observed when the vaccine was not used. 6Moreover, the importance of PCV in reducing the incidence of pneumococcal community-acquired pneumonia by about 23% in a low-income, low-mortality developing Asian country, the Philippines, has recently been clearly demonstrated by Lucero et al. 7 Finally, the use of Hib vaccines and PCV can induce significant herd immunity, thus justifying the conclusion that both should used in Asian children.
Population screening by Guthrie test for phenylketonuria in South-east Scotland. Report by the consultant paediatricians and medical officers of health of the S.E. Scotland Hospital Region.
Authors: D Douglas, J Farquhar, J Forfar, A Fraser, W Keay, R Mccrae, J Miller, J Gilloran, H Tait, M Langton, R Graham, Ih Wilson, G Riddell, M Grant, J Riddell, L Howitt, A Mccoubrey, J Campsie, W Simpson, R Wink
Journal: BMJ (1968)
Diseases of the Liver and Biliary System
Authors: Wade Volwiler
Journal: JAMA (1976)

<b>Diseases of the Liver,</b>edited by Leon Schiff, ed 4; 1,461 pp, 558 illus, $69, Philadelphia, Lippincott, 1975. These are now the two most authoritative books, for English-speaking countries, on the human hepatobiliary system and its diseases. Each almost completely covers this large field, is very up-to-date, and critically written. While having similar organization, they are different in writing style and approach: Sherlock's book, prepared by one person (a monumental and admirable task!), yields optimal coordination of material, an absence of unnecessary redundancy, and a uniform writing style. Although confined to 800 pages, this volume is truly encyclopedic—a quality achieved by an extremely efficient use of language in a succinct and very direct writing style. Her approach is one of great clarity and practicality; since development of scholarly depth is not an objective, this plan allows the product to be so compact. Dr Schiff's larger volume contains about three times
Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells
Authors: Cindy S. Ma, Nathan J. Hare, Kim E. Nichols, Loic Dupré, Grazia Andolfi, Maria-Grazia Roncarolo, Stephen Adelstein, Philip D. Hodgkin, Stuart G. Tangye
Journal: Journal of Clinical Investigation (2005)

X-linked lymphoproliferative disease (XLP) is an often-fatal immunodeficiency characterized by hypogammaglobulinemia, fulminant infectious mononucleosis, and/or lymphoma. The genetic lesion in XLP, SH2D1A, encodes the adaptor protein SAP (signaling lymphocytic activation molecule–associated [SLAM-associated] protein); however, the mechanism(s) by which mutations in SH2D1A causes hypogammaglobulinemia is unknown. Our analysis of 14 XLP patients revealed normal B cell development but a marked reduction in the number of memory B cells. The few memory cells detected were IgM+, revealing deficient isotype switching in vivo. However, XLP B cells underwent proliferation and differentiation in vitro as efficiently as control B cells, which indicates that the block in differentiation in vivo is B cell extrinsic. This possibility is supported by the finding that XLP CD4+ T cells did not efficiently differentiate into IL-10+ effector cells or provide optimal B cell help in vitro. Importantly, the B cell help provided by SAP-deficient CD4+ T cells was improved by provision of exogenous IL-10 or ectopic expression of SAP, which resulted in increased IL-10 production by T cells. XLP CD4+ T cells also failed to efficiently upregulate expression of inducible costimulator (ICOS), a potent inducer of IL-10 production by CD4+ T cells. Thus, insufficient IL-10 production may contribute to hypogammaglobulinemia in XLP. This finding suggests new strategies for treating this immunodeficiency.
The Seventh International Congress on Rheumatic Diseases
Journal: Annals of the Rheumatic Diseases (1949)

In 1940 it had been planned to hold a CQngress of the Ligue Internationale contre le Rhumatisme in America, but this had to be cancelled because of the war.In 1945 there were rumours of an important Congress to be organized in the U.S.A. in 1948 or 1949, and by 1946 the late Professor Ralph Pemberton was hard at work making prepara- tions for this event.His unceasing efforts on
Selection
Authors: A. Paton
Journal: BMJ (1995)

<h3>Background and purpose</h3> In patients with large vessel occlusions, endovascular treatment (ET) has been shown to be superior to intravenous thrombolysis (IVT) in recent trials. However, the effectiveness of ET in elderly patients is uncertain. <h3>Methods</h3> Using our stroke database, we compared the rates of good outcome (modified Rankin scale (mRS) ≤2), excellent outcome (mRS 0–1), poor outcome (mRS 5–6) at discharge, in-hospital death, infarct size, and symptomatic intracranial hemorrhage (SICH) in patients aged ≥80 years with distal intracranial carotid artery, M1 and M2 occlusions during two time periods. <h3>Results</h3> From January 2008 to October 2012, 217 patients were treated with IVT and, from November 2012 to October 2017, 209 patients received ET with stent retrievers (with or without IVT). Significantly more patients in the ET group than in the IVT group had a good outcome (25% vs 16%, P&lt;0.05), as well as an excellent outcome (12% vs 4%, P&lt;0.01). Significantly fewer patients in the ET group than in the IVT group died (14% vs 22%, P&lt;0.05) or had a poor outcome (35% vs 52%, P&lt;001). The SICH rates were lower after ET than after IVT (1% vs 6%, P&lt;0.01), and the infarct sizes were smaller after ET than after IVT. <h3>Conclusions</h3> Compared with IVT, the routine use of ET significantly improved the early clinical and radiological outcome in patients with anterior circulation large vessel occlusions aged ≥80 years. Nevertheless, poor outcome rates were high so the role of ET needs to be defined further in this population.
Comparison of whole-blood eosinophil counts in extrinsic asthmatics with acute and chronic asthma.
Journal: BMJ (1982)

index of an increase in circulating adrenal oxysteroids.'Depression of eosinophil concentrations has been shown in response to surgery,2 trauma,3 exercise,4 and emotional stress.4The low eosinophil counts found in acute severe asthma are compatible with a stress response related to the higher cortisol concentrations.5The authors' argument that eosinophilia has a beneficial effect in chronic asthma while eosinopenia allows the development of acute asthma might lead one to expect that corticosteroids would produce an exacerbation of chronic asthma in association with their action of decreasing eosinophil counts.Yet even the authors agree that corticosteroids are beneficial in chronic asthma, and the recent controlled trial of Fanta et a16 also shows their importance in the treatment of acute asthma.
Physician and coding errors in patient records
Authors: S. S. Lloyd
Journal: JAMA (1985)

The Veterans Administration's discharge abstract system was studied to identify error frequency, source, and effect in five Veterans Administration hospitals. We reviewed 1,829 medical records from 21 services for concordance with the abstract; sampling provided 95% confidence for each service. Of these records, 1,499 (82%) differed from the abstract in at least one item. Of 20,260 items, 4,360 (22%) were incorrect, with three error sources: physician (62%), coding (35%), and keypunch (3%). We projected 2.14 physician and 0.81 coding errors in the average abstract. Eighty-nine percent of projected physician errors were failures to report a procedure or diagnosis. Coding was subjective and errors were synergistic with physician errors. We projected that correction of errors would change 19% of the records for diagnosis-related group purposes and substantially increase future resource allocation. This effect varied considerably by service. (<i>JAMA</i>1985;254:1330-1336)
American Journal of Clinical Pathology, Indianapolis
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Smoldering Multiple Myeloma (SMM) At High-Risk of Progression to Symptomatic Disease: A Phase III, Randomized, Multicenter Trial Based On Lenalidomide-Dexamethasone (Len-Dex) As Induction Therapy Followed by Maintenance Therapy with Len Alone Vs No Treatment
Authors: María-Victoria Mateos, Lucía López-Corral, Miguel Hernández, Pilar Giraldo, Javier De La Rubia, Felipe de Arriba, Laura Rosiñol, Juan José Lahuerta, Luis Palomera, Joan Bargay, Albert Oriol, Felipe Prosper, Javier López, Eduardo Olavarría, Maria Luz Martino, Ana-Isabel Teruel, Jose Mariano Hernández, Graça Esteves, Jose Mario JS Mariz, Fernando Leal-da-Costa, Adrian Alegre, Jose-Luis Guzman, Ana López de la Guía, Jose Baquero, Nuria Quintana, Jose Luis García, JesÃ°s F. San Miguel
Journal: Blood (2011)
"Professional Organization."
Authors: Wm. Porter
Journal: JAMA (1889)

<h3>To the Editor:</h3> —Your editorial of September 28th on "Professional Organization" is not likely to be without a response from the many physicians whom it concerns. This is the age of organizations, and while every true member of the medical profession would decry an association having for its chief aim the selfish advancement of the individual or a favored few, yet we all have a right to urge that which will bring the members of our guild into closer relationship. For many years the American Medical Association has stood, in numbers and importance, far beyond any other; but now we have new organizations which, though they may never rival the national body, are yet representative and growing larger each year. These societies, it seems to me, are midway in the large distance which lies between the American Medical and the State associations, and are composed mainly of men who are
Mutagenic Activity of Disinfection By-Products
Authors: Louis Cognet, Yves Courtois, Joel Mallevialle
Journal: Environmental Health Perspectives (1986)

Data on raw water quality, disinfection treatment practices, and the resulting mutagenic properties of the treated water were compiled from pilot- and full-scale treatment experiments to evaluate that parameter which might produce variability in the results of a mutagenic study. Analysis of the data and comparison of treatment practices indicated that the measured mutagenic activity is strongly related to the characteristics of the organic matter in the raw water, the methodology used to sample and detect mutagens, the scale of the study both in terms of treatment flow and period of study, and the point at which and the conditions under which oxidants are added during treatment. Conclusions regarding disinfection systems in full-scale water treatment plants include the following: When raw water is pretreated and high concentrations of organics are present in the raw water, both ozonation and chlorination increased mutagenic activity. However, no significant difference in mutagenicity was found between the two oxidants. Both in the case of a nitrified groundwater and a clarified surface water, the mutagenic activity of the water after ozonation was related to its mutagenic activity before ozonation. With ozonation, mutagenic activity decreased after granular activated carbon (GAC) filtration. Thus, when GAC filtration follows ozone disinfection, early addition of oxidants may not be deleterious to the finished water quality. When chlorine or chlorine dioxide is added after GAC filtration, chlorine dioxide was found to produce a less mutagenic water than chlorine. Although these conclusions suggest means of controlling mutagenic activity during treatment, it must be stressed that the measurement of mutagenicity is a presumptive index of contamination level.
Conflicts of interest in medical center/industry research relationships. Council on Scientific Affairs and Council on Ethical and Judicial Affairs
Journal: JAMA (1990)

Increasingly research carried out in university medical centers is funded by biotechnology firms. This collaboration raises the issue of conflict between a researcher's dedication to advancing medical knowledge and a researcher's desire to increase his or her income. This report by the AMA's Council on Scientific Affairs and the Council on Ethical and Judicial Affairs discusses the risks and benefits of a collaborative relationship to each party. It describes the different types of arrangements that exist between researchers and industry, and identifies the problems that may arise when a researcher or a medical center has a direct financial interest in a research program. The report concludes with ethical guidelines and recommendations for avoiding potential or actual conflicts of interest.
Physiological Attributes of Microbial BTEX Degradation in Oxygen-Limited Environments
Authors: Ronald H. Olsen, Mark D. Mikesell, Jerome J. Kukor, Armando M. Byrne
Journal: Environmental Health Perspectives (1995)

Our work has focused on the determination of physiological traits that may facilitate in situ degradation of xenobiotic compounds by indigenous microorganisms.For this our interests center on the following questions: What are the ambient conditions in a benzene, toluene, ethylbenzene, and xylene (BTEX)-contaminated aquifer?What is the behavior of indigenous bacteria under these conditions?What are the attributes of bacterial strains that are functional under hypoxic conditions?How do these strains compare with other BTEX-degrading strains? -
AMNIOTIC HERNIA CORRECTED BY OPERATION
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal