AB0479 RELATIONSHIP BETWEEN DISEASE ACTIVITY, ORGAN DAMAGE AND HEALTH-RELATED QUALITY OF LIFE AS ASSESSED BY LUPUSQOL AND SF-36 IN 400 RUSSIAN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: E. Aseeva, S. Solovyev, S. Glukhova, A. Lila
Journal: Annals of the Rheumatic Diseases (2022)

Objectives We conducted this study to compare the efficiency of LupusQoL with the 36-item Short-Form Health Survey (SF-36), a generic quality of life (QoL) scale, in Russian patients with lupus. Methods Both questionnaires were conducted for one visit to the clinic. Disease activity was evaluated by the SLEDAI-2K, while the chronic damage was assessed by the Systemic Lupus International Collaborating Clinics Damage Index score (SDI). Associations between the LupusQoL and SF-36 domains were examined according to SLEDAI 2K and SDI. Results A total of 400 patients with lupus (F/M 363:37, mean age 34,2±11.5 years, mean disease duration 106,3±91,9.0 months) were included. All patients were divided into 4 groups: SLEDAI 2K ≤4 – 136 pts, SLEDAI-2K ≥4 – 264 pts, SDI =0 – 177 pts, SDI ≥1 – 223 pts. QOL as assessed by SF-36 and LupusQoL was low in all groups of patients with SLE. The mean scores for each of the domains of the LupusQoL and SF-36 are shown in Table 1. Table 1. Relationship between disease activity, organ damage and health-related quality of life as assessed by LupusQoL and SF-36 in 400 Russian patients with systemic lupus erythematosus LupusQoLdomains SLEDAI 2K≤4Mean (SD) SLEDAI 2K ≥4Mean (SD) P SF-36domains SLEDAI2K ≤4Mean (SD) SLEDAI-2K ≥4Mean (SD) P Comparable Physical health 70,1±22,1 64,9±23,6 0,07 PF 65,6±28,2 60,6±28,5 0,1 Emotional health 67,3±24,8 63,2±24,6 0,13 MH 52,2±9,0 49,6±7,8 0,001 Pain 74,7±23,6 67,5±24,8 0,007 BP 46,3±9,5 47,3±8,4 0,09 Fatigue 65,7±24,5 65,5±24,8 0,22 VT 55,5±23,3 48,3±9,5 0,007 Noncomparable Planning 71,1±27,9 60,1±28,0 0,0004 SF 71,0±24,0 71,1±24,1 0,003 Intimaterelationships 78,3±28,7 69,9±31,1 0,003 GH 55,9±18,7 55,9±18,7 0,34 Burden to others 61,2±26,8 54,2±28,1 0.003 RE 59,3±42,4 59,3±42,4 0,012 Body image 71,1±24,7 62,2±28,5 0,007 RP 65,6±28,2 65,6±28,2 0,028 LupusQoLdomains SDI =0 Mean (SD ) SDI ≥1 Mean (SD ) P SF-36 domains SDI =0 Mean (SD ) SDI ≥1 Mean (SD ) P Comparable Physical health 71,2±22.5 63,3±23,1 0,002 PF 69,2±27,4 57,1±28,2 0,0007 Emotional health 66,2±25,2 63,3±24,3 0,24 MH 50,31±7,9 50,6±8,7 0,6 Pain 72,3±24,2 68,2±24,8 0,03 BP 47,02±8,4 46,9±9,1 0,84 Fatigue 65,7±25,3 60,35±24,1 0,03 VT 55,6±20,3 49,5±24,9 0.02 Noncomparable Planning 67,7±27,3 60,9±29.1 0.03 SF 64,05±28,1 60,5±26,4 0,21 Intimaterelationships 76,1±28,4 70,6±32,5 0,22 GH 52,11±20,2 47,41±20,1 0.06 Burden to others 55,7±28,4 57,4±27,3 0,68 RE 56,29±42,1 46,9±41,8 0,06 Body image 66,6±27,9 64,1±27,3 0,33 RP 50,54±42,4 39,15± 13,1 0,0001 It was shown that the domain of pain of the LupusQoL questionnaire (p&lt;0.007) statistically significantly responds to disease activity in contrast to the comparable SF-36 scale. The domains MH (p&lt;0.001) аnd VT (p&lt;0.007) of the SF-36 are more sensitive to change of disease activity. It was found that in patients with SLE with a high activity of the disease, the noncomparable domains such as Planning (p&lt;0.0004), Intimate relationship (p&lt;0.003), Burden to others (p&lt;0.03), Body image (p&lt;0.007) significantly change. The QOL in patients with SLE with SDI ≥1 was poor in the domain of Physical health of the LupusQoL and in the comparable domain of the SF-36 PF. Higher QOL in these domains was in patients without damages. The domains Fatigue and VT are also significantly affected by the damage. So, in patients with SDII ≥1, there was a significant decrease of QOL in these domains up to 60.35±24.0 and 49.55±20.32, respectively, as compared with patients without damages 65.7±25.3 (p≤0.03) and 55.69±20.32 (p≤0.02) respectively. Conclusion LupusQoL is more sensitive to changes in SLE activity. Both SF-36 and LupusQoL are equally sensitive to changes in organ damage. Disclosure of Interests None declared