tbuckley/cabot-search huggingface dataset:
Outcomes after allogeneic hematopoietic cell transplant in patients diagnosed with blast phase of myeloproliferative neoplasms: A retrospective study from the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation
Authors: Guillermo Ortí, Luuk Gras, Nienke Zinger, Maria Chiara Finazzi, Katja Sockel, Marie Robin, Edouard Forcade, Daniele Avenoso, Nicolaus Kröger, Jürgen Finke, Aleksandar Radujkovic, Mathilde Hunault‐Berger, Wilfried Schroyens, Tsila Zuckerman, Jean Henri Bourhis, Yves Chalandon, Adrian Bloor, Rik Schots, Liesbeth C. de Wreede, Joana Drozd‐Sokolowska, Kavita Raj, Nicola Polverelli, Tomasz Czerw, Juan Carlos Hernández‐Boluda, Donal McLornan, Ibrahim Yakoub‐Agha
Journal: American Journal of Hematology (2023)

Allogeneic hematopoietic cell transplant (allo-HCT) provides the only potential route to long-term remission in patients diagnosed with blast phase transformation of myeloproliferative neoplasm (BP-MPN). We report on a large, retrospective European Society for Blood and Marrow Transplantation registry-based study of BP-MPN patients undergoing allo-HCT. BP-MPN patients undergoing first allo-HCT between 2005 and 2019 were included. A total of 663 patients were included. With a median follow-up of 62 months, the estimated 3-year overall survival (OS) was 36% (95% confidence interval [CI], 32-36). Factors associated with lower OS were Karnofsky Performance Score (KPS) <90 (hazard ratio [HR] 1.65, p < .001) and active disease at allo-HCT (HR 1.45, p < .001), whereas patients undergoing allo-HCT more recently associated with a higher OS (HR 0.96, p = .008). In a selected patient's population, the 3-year OS of patients undergoing allo-HCT in complete response (CR) and with a KPS ≥90 was 60%. KPS < 90 (HR 1.4, p = .001) and active disease (HR 1.44, p = .0004) were associated with a lower progression-free survival (PFS). Conversely, most recent allo-HCT associated with a higher PFS (HR 0.96, p = .008). Active disease at allo-HCT (HR 1.34, p = .03) was associated with a higher cumulative incidence of relapse (RI) and allo-HCT in earlier calendar years (HR 0.96, p = .02) associated with a lower RI. Last, KPS < 90 (HR 1.91, p < .001), active disease (HR 1.74, p = .003) and allo-HCT from mismatched related donors were associated with a higher non-relapse mortality (HR 2.66, p = .003). In this large series of BP-MPN patients, about one third were alive at 3 years after transplantation. Patients undergoing allo-HCT in the more recent era, with a KPS ≥90 and in CR at transplant had a better prognosis.
Sotatercept for pulmonary arterial hypertension: something old and something new
Authors: Lewis J. Rubin, Robert Naeije
Journal: European Respiratory Journal (2023)

<b>Sotatercept is a drug that targets a novel pathogenic pathway in pulmonary arterial hypertension and has the potential to be an effective new therapy for this condition</b>https://bit.ly/3s1tQb1
<i>Aspergillus</i>sensitisation: an underappreciated treatable trait in airway disease
Authors: Jennifer Pollock, James D. Chalmers
Journal: European Respiratory Journal (2023)

In 2006, Denning et al. [1] first proposed, in the European Respiratory Journal , the term "severe asthma with fungal sensitisation (SAFS)" to describe a distinct phenotype of severe asthma characterised by an elevated IgE-mediated response towards fungal allergens. Since then, SAFS has been widely studied and is generally considered to sit within a spectrum of disease ranging from uncomplicated asthma to frank allergic bronchopulmonary aspergillosis/mycosis (ABPA/ABPM) [2, 3]. Fungal sensitisation, particularly towards Aspergillus species, has been highlighted as a potential "treatable trait" in airway disease, with anti-fungal therapy and inhaled/oral corticosteroids forming the basis of treatment [2, 4, 5]. Sensitisation to Aspergillus is associated with increased exacerbations in patients with COPD <http://bit.ly/3i4LVD9>
Transbronchial cryobiopsy in lung transplantation: risk, reward and relevance
Authors: Dominic Thomas Keating, John Taverner
Journal: European Respiratory Journal (2023)

<b>Transbronchial lung cryobiopsy increased diagnostic yield in mechanically ventilated post-lung transplant recipients in a single centre study, with a reasonable safety profile. Long-term outcomes resulting from improved yield still need to be assessed.</b>http://bit.ly/3EpPU5Y
Acknowledgment to Reviewers
Journal: Blood Cancer Discovery (2023)

The Blood Cancer Discovery editors wish to acknowledge with sincere appreciation the assistance of the following reviewers who have generously contributed their time and effort during the past year1 in the appraisal of manuscripts. These reviewers have been enormously helpful in assessing the merit of original articles: their careful analysis and critique and their constructive recommendations have greatly enhanced the value of manuscripts they have handled. The quality of the journal can be attributed in large measure to the quality of their effort. We are sincerely grateful.Abdel-Wahab, O.Aifantis, I.Albert, R.Alizadeh, A.Ansell, S.Aplan, P.Armstrong, S.Asimakopoulos, F.Barwick, B.Ben-Neriah, Y.Bergsagel, P.Bhalla, K.Boise, L.Brentjens, R.Bustoros, M.Calado, D.Campo, E.Casero, R.Casola, S.Cellot, S.Cerchietti, L.Challen, G.Chesi, M.Ciminale, V.Crispino, J.Croce, C.Davies, F.Davis, K.DeGregori, J.Dhakal, B.Dhodapkar, M.Donnadieu, E.Doulatov, S.Edwards, C.Elemento, O.Elenitoba-Johnson, K.Elf, S.Esteller, M.Ezponda, T.Falini, B.Fernández de Larrea, C.Ferrando, A.Flowers, C.Freud, A.Galardy, P.Gartenhaus, R.Gattei, V.Ghia, P.Ghobrial, I.Gojo, I.Goodell, M.Gottschalk, S.Green, M.Greenberger, L.Grembecka, J.Gruber, T.Gutierrez, A.Hasserjian, R.Herranz, D.Hirao, A.Hourigan, C.Huang, S.Iacobucci, I.Jaffe, E.Jagannath, S.Jones, C.Kaiser, M.Kataoka, K.Kharas, M.Kislinger, T.Klein, U.Klusmann, J.Knorr, D.Kupper, T.Le Beau, M.Lee, S.Letai, A.Levine, R.Levy, R.Ley, T.Li, L.Licht, J.Lim, S.Lindsley, R.Lyden, D.Magee, J.Majeti, R.Majzner, R.Martin, T.Maus, M.McCarthy, P.Mead, A.Melenhorst, J.Melnick, A.Morelli, E.Mullally, A.Mullighan, C.Nadel, B.Neeson, P.Ní Chonghaile, T.Nichols, G.Obeng, E.Ogawa, S.Paiva, B.Palomero, T.Parekh, S.Park, C.Pasqualucci, L.Passegué, E.Pietras, E.Reinhardt, H.Riddell, S.Roddie, C.Romine, K.Rooney, C.Rossi, D.Rutella, S.Sadelain, M.Savona, M.Schimmer, A.Schrump, D.Schwenger, E.Shah, NiraliShah, NinaShanmugam, M.Shannon, K.Siebert, R.Steensma, D.Stock, W.Strati, P.Sulis, M.Tothova, Z.Trumpp, A.Tyner, J.Vago, L.Vakoc, C.van de Donk, N.van Galen, P.Vardhana, S.Verma, A.Vermeer, M.Verneris, M.Viny, A.Vose, J.Vyas, P.Wang, S.Weiner, G.Weinhold, N.Wilson, W.Xu, J.Yang, J.Younes, A.Young, K.Yu, J.
In This Issue
Journal: Blood Cancer Discovery (2023)

In This Issue| January 06 2023 In This Issue Author & Article Information Online ISSN: 2643-3249 Print ISSN: 2643-3230 ©2023 American Association for Cancer Research2023American Association for Cancer Research Blood Cancer Discov (2023) 4 (1): 1. https://doi.org/10.1158/2643-3230.BCD-4-1-ITI Related Content A commentary has been published: Distinct Genetically Determined Origins of Myd88/BCL2-Driven Aggressive Lymphoma Rationalize Targeted Therapeutic Intervention Strategies A commentary has been published: A Therapeutically Targetable NOTCH1–SIRT1–KAT7 Axis in T-cell Leukemia A commentary has been published: ETV6 Deficiency Unlocks ERG-Dependent Microsatellite Enhancers to Drive Aberrant Gene Activation in B-Lymphoblastic Leukemia View more A commentary has been published: Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses View less Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record January 6 2023 Citation In This Issue. Blood Cancer Discov 1 January 2023; 4 (1): 1. https://doi.org/10.1158/2643-3230.BCD-4-1-ITI Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Activated NOTCH1 is a common driver of T-cell acute lymphoblastic leukemia (T-ALL). Due to the toxicity of and resistance to NOTCH1 inhibitors, therapies targeting molecules downstream of NOTCH1 might help treat relapsed patients. In this study, Lancho et al. reveal that NOTCH1 directly activates SIRT1 transcription through a distal enhancer element. Genetic loss or inhibition of SIRT1 leads to significant antileukemic effects in mouse models with different SIRT1 allelic dosages. Mechanistically, the oncogenic effects of SIRT1 are mediated, at least in part, by its deacetylation and activation of KAT7. These results uncover the therapeutic potential of SIRT1-KAT7 axis inhibition in T-ALL. ■ See article, p. 12. The regulatory targets of the ETS repressor ETV6, a candidate tumor suppressor in B-lymphoblastic leukemia (B-ALL), have remained poorly understood. Kodgule, Goldman, Monovich et al. show that ETV6 binds to genomic short tandem repeats of the sequence ‘GGAA’ that are repressed in normal... You do not currently have access to this content.
Peptide-guided delivery improves the therapeutic efficacy and safety of glucocorticoid drugs for treating acute lung injury
Authors: Hong Guo, Jibin Guan, Xian Wu, Yushuang Wei, Jiaqi Zhao, Yan Zhou, Faqian Li, Hong-Bo Pang
Journal: Molecular Therapy (2023)

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening conditions with excessive inflammation in the lung. Glucocorticoids had been widely used for ALI/ARDS, but their clinical benefit remains unclear. Here, we tackled the problem by conjugating prednisolone (PSL) with a targeting peptide termed CRV. Systemically administered CRV selectively homes to the inflamed lung of a murine ALI model, but not healthy organs or the lung of healthy mice. The expression of the CRV receptor, retinoid X receptor β, was elevated in the lung of ALI mice and patients with interstitial lung diseases, which may be the basis of CRV targeting. We then covalently conjugated PSL and CRV with a reactive oxygen species (ROS)-responsive linker in the middle. While being intact in blood, the ROS linker was cleaved intracellularly to release PSL for action. In vitro, CRV-PSL showed an anti-inflammatory effect similar to that of PSL. In vivo, CRV conjugation increased the amount of PSL in the inflamed lung but reduced its accumulation in healthy organs. Accordingly, CRV-PSL significantly reduced lung injury and immune-related side effects elsewhere. Taken together, our peptide-based strategy for targeted delivery of glucocorticoids for ALI may have great potential for clinical translation.
Evidence that oncostatin M synergizes with IL-4 signaling to induce TSLP expression in chronic rhinosinusitis with nasal polyps
Authors: Bao-Feng Wang, Ping-Ping Cao, James E. Norton, Julie A. Poposki, Aiko I. Klingler, Lydia A. Suh, Roderick Carter, Julia H. Huang, Junqin Bai, Whitney W. Stevens, Bruce K. Tan, Anju T. Peters, Leslie C. Grammer, David B. Conley, Kevin C. Welch, Zheng Liu, Robert C. Kern, Atsushi Kato, Robert P. Schleimer
Journal: Journal of Allergy and Clinical Immunology (2023)
An exosome-based liquid biopsy signature for pre-operative identification of lymph node metastasis in patients with pathological high-risk T1 colorectal cancer
Authors: Katsuki Miyazaki, Yuma Wada, Keisuke Okuno, Tatsuro Murano, Yuji Morine, Tetsuya Ikemoto, Yu Saito, Hiroaki Ikematsu, Yusuke Kinugasa, Mitsuo Shimada, Ajay Goel
Journal: Molecular Cancer (2023)

According to current guidelines, more than 70% of patients with invasive submucosal colorectal cancer (T1 CRC) undergo a radical operation with lymph node dissection, even though only ~ 10% have lymph node metastasis (LNM). Hence, there is imperative to develop biomarkers that can help robustly identify LNM-positive patients to prevent such overtreatments. Given the emerging interest in exosomal cargo as a source for biomarker development in cancer, we examined the potential of exosomal miRNAs as LNM prediction biomarkers in T1 CRC.We analyzed 200 patients with high-risk T1 CRC from two independent cohorts, including a training (n = 58) and a validation cohort (n = 142). Cell-free and exosomal RNAs from pre-operative serum were extracted, followed by quantitative reverse-transcription polymerase chain reactions for a panel of miRNAs.A panel of four miRNAs (miR-181b, miR-193b, miR-195, and miR-411) exhibited robust ability for detecting LNM in the exosomal vs. cell-free component. We subsequently established a cell-free and exosomal combination signature, successfully validated in two independent clinical cohorts (AUC, 0.84; 95% CI 0.70-0.98). Finally, we developed a risk-stratification model by including key pathological features, which reduced the false positive rates for LNM by 76% without missing any true LNM-positive patients.Our novel exosomal miRNA-based liquid biopsy signature robustly identifies T1 CRC patients at risk of LNM in a preoperative setting. This could be clinically transformative in reducing the significant overtreatment burden of this malignancy.
Errors and complications in clinical periodontal practice due to methodologic bias and bad interpretation of the evidence
Authors: Leandro Chambrone, Francisco Salvador Garcia‐Valenzuela, Gustavo Avila‐Ortiz
Journal: Periodontology 2000 (2023)

Abstract Different types of errors and complications may arise during and after the execution of periodontal or implant‐related procedures. Some of the most relevant, although also controversial, and less commented, causative agents of errors and complications are methodological biases and bad interpretation of the evidence. Proper assessment of the literature requires of solid clinical knowledge combined with a systematic approach built on the recognition of common methodological biases and the avoidance of interpretive errors to critically retrieve, dissect, and judiciously apply available information for the promotion of periodontal and peri‐implant health. This review addresses common types of methodological bias and interpretive errors that can alter the reader's perceptions on the real effect and potential ramifications of the reported outcomes of a given therapeutic approach due to bad interpretation of the available evidence: (1) types of methodological biases; (2) spin and interpretive bias; (3) interpretation pitfalls when assessing the evidence (4) choice of relevant endpoints to answer the question(s) of interest; and (5) balance between statistical significance and clinical relevance.
Real-world time trends in overall survival, treatments and patient characteristics in HR+/HER2− metastatic breast cancer: an observational study of the SONABRE Registry
Authors: Marissa Meegdes, Sandra M.E. Geurts, Frans L.G. Erdkamp, M. Wouter Dercksen, Birgit E.P.J. Vriens, Kirsten N.A. Aaldering, Manon J.A.E. Pepels, Linda M.H. van de Winkel, Natascha A.J.B. Peters, Jolien Tol, Joan B. Heijns, Agnes J. van de Wouw, Aude J.O. de Fallois, Maartje A.C.E. van Kats, Vivianne C.G. Tjan-Heijnen
Journal: The Lancet Regional Health - Europe (2023)

This study aims to evaluate whether changes in therapeutic strategies have improved survival of patients diagnosed with hormone receptor positive (HR+), HER2 negative (HER2-) advanced breast cancer (ABC) in real-world.
The evolutionary tuning of hearing
Authors: Marcela Lipovsek, Ana Belén Elgoyhen
Journal: Trends in Neurosciences (2023)

After the transition to life on land, tympanic middle ears emerged separately in different groups of tetrapods, facilitating the efficient detection of airborne sounds and paving the way for high frequency sensitivity. The processes that brought about high-frequency hearing in mammals are tightly linked to the accumulation of coding sequence changes in inner ear genes; many of which were selected during evolution. These include proteins involved in hair bundle morphology, mechanotransduction and high endolymphatic potential, somatic electromotility for sound amplification, ribbon synapses for high-fidelity transmission of sound stimuli, and efferent synapses for the modulation of sound amplification. Here, we review the molecular evolutionary processes behind auditory functional innovation. Overall, the evidence to date supports the hypothesis that changes in inner ear proteins were central to the fine tuning of mammalian hearing.
MetaBinner: a high-performance and stand-alone ensemble binning method to recover individual genomes from complex microbial communities
Authors: Ziye Wang, Pingqin Huang, Ronghui You, Fengzhu Sun, Shanfeng Zhu
Journal: Genome biology (2023)

Abstract Binning aims to recover microbial genomes from metagenomic data. For complex metagenomic communities, the available binning methods are far from satisfactory, which usually do not fully use different types of features and important biological knowledge. We developed a novel ensemble binner, MetaBinner, which generates component results with multiple types of features by k-means and uses single-copy gene information for initialization. It then employs a two-stage ensemble strategy based on single-copy genes to integrate the component results efficiently and effectively. Extensive experimental results on three large-scale simulated datasets and one real-world dataset demonstrate that MetaBinner outperforms the state-of-the-art binners significantly.
Oral Ritlecitinib and Brepocitinib for Moderate-to-Severe Ulcerative Colitis: Results From a Randomized, Phase 2b Study
Authors: William J Sandborn, Silvio Danese, Jaroslaw Leszczyszyn, Jacek Romatowski, Engin Altintas, Elena Peeva, Mina Hassan-Zahraee, Michael S Vincent, Padmalatha S Reddy, Christopher Banfield, Mikhail Salganik, Anindita Banerjee, Jeremy D Gale, Kenneth E Hung
Journal: Clinical Gastroenterology and Hepatology (2023)
Targeting Lin28 axis enhances glypican-3-CAR T cell efficacy against hepatic tumor initiating cell population
Authors: Tapas Patra, David M. Cunningham, Keith Meyer, Karoly Toth, Ratna B. Ray, Andras Heczey, Ranjit Ray
Journal: Molecular Therapy (2023)

Overexpression of Lin28 is detected in various cancers with involvement in the self-renewal process and cancer stem cell generation. In the present study, we evaluated how the Lin28 axis plays an immune-protective role for tumor-initiating cancer cells in hepatocellular carcinoma (HCC). Our result using HCC patient samples showed a positive correlation between indoleamine 2,3-dioxygenase-1 (IDO1), a kynurenine-producing enzyme with effects on tumor immune escape, and Lin28B. Using in silico prediction, we identified a Sox2/Oct4 transcriptional motif acting as an enhancer for IDO1. Knockdown of Lin28B reduced Sox2/Oct4 and downregulated IDO1 in tumor-initiating hepatic cancer cells. We further observed that inhibition of Lin28 by a small-molecule inhibitor (C1632) suppressed IDO1 expression. Suppression of IDO1 resulted in a decline in kynurenine production from tumor-initiating cells. Inhibition of the Lin28 axis also impaired PD-L1 expression in HCC cells. Consequently, modulating Lin28B enhanced in vitro cytotoxicity of glypican-3 (GPC3)-chimeric antigen receptor (CAR) T and NK cells. Next, we observed that GPC3-CAR T cell treatment together with C1632 in a HCC xenograft mouse model led to enhanced anti-tumor activity. In conclusion, our results suggest that inhibition of Lin28B reduces IDO1 and PD-L1 expression and enhances immunotherapeutic potential of GPC3-CART cells against HCC.
Are type III devices the future of sleep disordered breathing management?
Authors: Patrick Lévy, Sophia Schiza
Journal: European Respiratory Journal (2023)

<b>To diagnose sleep apnoea, novel devices and emerging technologies are being increasingly used. Portable monitoring (PM) also benefits from telemedicine and artificial intelligence. PM should be further validated in terms of clinical outcomes in OSA.</b>https://bit.ly/3ge1hEy
Comparison of the International Consensus and 5th WHO edition classifications of adult myelodysplastic syndromes and acute myeloid leukemia
Authors: Brunangelo Falini, Maria Paola Martelli
Journal: American Journal of Hematology (2023)

Abstract Several editions of the World Health Organization (WHO) classifications of lympho‐hemopoietic neoplasms in 2001, 2008, and 2016 served as the international standard for diagnosis. Since the 4th WHO edition, here referred as WHO‐HAEM4, significant clinico‐pathological, immunophenotypic, and molecular advances have been made in the field of myeloid neoplasms, which have contributed to refine diagnostic criteria, to upgrade entities previously defined as provisional and to identify new entities. This process has resulted in two recent classification proposals of myeloid neoplasms: the International Consensus Classification (ICC) and the 5th edition of the WHO classification (WHO‐HAEM5). In this paper, we review and compare the two classifications in terms of diagnostic criteria and entity definition, with a focus on adult myelodysplastic syndromes/neoplasms (MDS) and acute myeloid leukemia (AML). The goal is to provide a tool to facilitate the work of pathologists, hematologists and researchers involved in the diagnosis and treatment of these hematological malignancies.
The new 2022 pulmonary hypertension guidelines: some small steps and some giant leaps forward for evidence-based care
Authors: Laura C. Price, Jason Weatherald
Journal: European Respiratory Journal (2023)

<b>The 2022 ESC/ERS pulmonary hypertension guidelines reflect updated definitions, diagnosis and management recommendations based on current evidence. Multidisciplinary, patient-centred care and key areas for new research are central to the new guidelines.</b> http://bit.ly/3UyswZR
A young woman with persistent sore throat, <scp>Epstein–Barr</scp> virus, lymphadenopathy, and aberrant <scp>CD4</scp> + <scp>CD7</scp>‐ T‐cells
Authors: Mariam Goubran, Eric McGinnis, Ryan J. Stubbins, Hamish Nicolson, Persia Pourshahnazari, Sara Belga, Hayley Merkeley, Thomas J. Nevill, Luke Y. C. Chen
Journal: American Journal of Hematology (2023)

A young woman with persistent EBV viremia and lymphocytosis had an abnormal CD4- T cell population with aberrant loss of CD7. She had a diagnosis of chronic active EBV (CAEBV), a lymphoproliferative disorder for which she ultimately required allogeneic hematopoietic stem cell transplantation. The authors have no conflict of interest to declare. The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.