tbuckley/cabot-search huggingface dataset:
Assault after ingestion of antidepressant.
Authors: T Hughes, P Sugarman
Journal: BMJ (1991)

Dobbs and Fleming have succeeded in using history, symptoms, and dipstick tests to distinguish between the "urethral syndrome" and urinary infection where many others have failed.9However, our own experience with these criteria has been disappointing.Ditchburn and Ditchburn's use of microscopy9 is commendable, and we have also recommended it.However, some patients without significant bacteriuria have pyuria and some with significant bacteriuria have few if any leucocytes in their urine." Further, not all medical students are taught to use a microscope well enough to be able to recognise leucocytes in urine.Thus, the use of the microscope would require postgraduate training in many cases.
Concordance Between Intracervical and Fundal Injections for Sentinel Node Mapping in Patients With Endometrial Cancer? A Study Using Intracervical Radiotracer and Fundal Blue Dye Injections: Reply
Authors: Maliheh Hasanzadeh Mofrad, Marjaneh Farazestanian, Zohreh Yousefi, Leili Zarifmahmoudi, Sima Kadkhodayan, Ramin Sadeghi
Journal: Clinical Nuclear Medicine (2019)

Hasanzadeh Mofrad, Maliheh MD∗; Farazestanian, Marjaneh MD∗; Yousefi, Zohreh MD∗; Zarifmahmoudi, Leili PhD∗,†; Kadkhodayan, Sima MD∗,†; Sadeghi, Ramin MD∗,†Author Information
Penetration of Chemicals into the Oocyte, Uterine Fluid, and Preimplantation Blastocyst
Authors: Sergio Fabro
Journal: Environmental Health Perspectives (1978)

Chemicals, including commonly used drugs (e.g., penicillin, meprobamate, pyridium, and mercaptomerin) penetrate and persist for some time in the ovarian follicular fluid at concentrations approximately similar to that of the serum. Information as to the penetration of chemicals into the granulosa cells and into the oocyte is scanty, although there are some indications that these structures are also permeable to foreign chemicals. Similarly, caffeine, nicotine, thiopental, salicylic acid, antipyrine, barbital, and isoniazid enter the uterine secretion and penetrate the preimplantation blastocyst of mice, rats and rabbits. The pattern of distribution of compounds among ovarian follicular fluid, uterine luminal fluid, blastocyst and plasma varies from compound to compound and appears to be related to the molecular weight and degree of ionization of the compound and differs in pregnant and nonpregnant animals. Thus, nicotine and DDT accumulate in the uterine luminal fluid of pregnant but not in that of nonpregnant rabbits. The penetration of foreign chemicals into the oocyte, uterine luminal fluid, and preimplantation blastocyst may exert adverse effects on fertilization, implantation, and/or further development of the conceptus. The possible toxicological importance of this process to eutherian reproduction is discussed.
RPS Resolutions to Be Acted on by the AMA House of Delegates
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Risk of serious acute neurological illness after immunization with diphtheria-tetanus-pertussis vaccine. A population-based case-control study
Authors: J. L. Gale
Journal: JAMA (1994)

<h3>Objective.</h3> —To evaluate the association between serious acute neurological illness and receipt of whole-cell pertussis vaccine, given as diphtheria-tetanus-pertussis (DTP) vaccine. <h3>Design.</h3> —Population-based case-control study. <h3>Setting.</h3> —Outpatient and inpatient hospital settings, physician practices, and the general population in Washington and Oregon states. <h3>Subjects.</h3> —A total of 424 confirmed cases of neurological illness were identified prospectively during a 12-month period by statewide active surveillance from the population of 218000 children 1 to 24 months of age living in Washington and Oregon (estimated 368 000 DTP immunizations given). Each case child was matched to two population control children by birth date (±5 days), gender, and county of birth. Written immunization records were used to determine whether illness occurred within 7 days of immunization in case children, or within 7 days of the same reference date in control children, thus qualifying as exposed. <h3>Main Outcome Measures.</h3> —Outpatient and inpatient cases of complex febrile seizures, seizures without fever, infantile spasms, and acute encephalitis/ encephalopathy confirmed by an expert panel masked to immunization history. <h3>Results.</h3> —The estimated odds ratio (OR) for onset of serious acute neurological illness within 7 days for young children exposed to DTP vaccine was 1.1 (95% confidence interval [Cl], 0.6 to 2.0). When the analysis was restricted to children with encephalopathy or complicated seizures and adjusted for factors possibly affecting vaccine administration, the OR was 3.6 (95% Cl, 0.8 to 15.2). Odds ratios for specific study diagnoses varied, but all Cls included 1. No elevated risk was observed for the largest group of illnesses studied, nonfebrile seizures (OR, 0.5; 95% Cl, 0.2 to 1.5). <h3>Conclusions.</h3> —This study did not find any statistically significant increased risk of onset of serious acute neurological illness in the 7 days after DTP vaccine exposure for young children. (<i>JAMA</i>. 1994;271:37-41)
Geriatrics
Authors: Isadore Rossman
Journal: JAMA (1980)

There appears to be growing agreement regarding the existence of an identifiable and substantive body of medical knowledge that can be called geriatrics, whether it is taught in a separate course or scattered through the medical and postgraduate curriculums. The present book, volume 1 of a<i>Guidelines in Medicine</i>series, successfully expounds some of this knowledge and does so in an economical, almost summary, manner. Unlike weightier textbooks of geriatric medicine, this volume will more readily skim off the cream for those who wish to read and run. In concise form the geriatric topics considered include special features of medicine in old age, mental disorders, CNS and special senses, nutrition, principles of drug therapy, and the various systems—cardiovascular, urogenital, and respiratory—all in some 340 pages. Many interesting topics—"senile squalor syndrome," differential diagnosis of falls, hypothermia, and heart murmurs of the elderly—are succinctly described. Based on English experience, some of the
LAW &amp; MEDICINE
Authors: Angel a
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute Heat Stroke
Authors: Thomas F. O'Donnell
Journal: JAMA (1975)

Fifteen Marine recruits with acute heat stroke were examined for (1) predisposing factors, (2) blood coagulation disturbances, (3) renal function abnormalities, and (4) blood composition alterations. Epidemiologic data identified the following risk factors: previous residence in a temperate climate, first phase of training, fatigue, and strenuous exercise in hot, humid conditions. Results of blood coagulation studies disclosed an increase in prothrombin and partial thromboplastin times, with a decrease in platelet count, probably indicating a transient, low-grade consumptive process. Blood urea nitrogen and creatinine levels and creatinine clearance were normal. Only mild elevations of SGOT, SGPT, and lactic dehydrogenase levels were noted, and in combination with clinical observations, they argued against significant muscle damage. No deaths or instances of renal failure occurred. (<i>JAMA</i>234:824-828, 1975)
William Murrell (1853-1912) Clinical Pharmacologist and Toxicologist
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A City Set on a Hill: The Significance of the Health Demonstration at Syracuse, New York
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Humoral immunostimulation. IV. Role of complement.
Authors: W T Shearer, J P Atkinson, M M Frank, C W Parker
Journal: The Journal of Experimental Medicine (1975)

When L cells were treated with anti-L-cell antibody in medium containing heat-inactivated fetal calf serum, nucleoside uptake and cell growth were stimulated. The response was markedly increased when fresh, unheated sera from calves, guinea pigs, humans, mice, or rabbits were also present. The factors in unheated serum responsible for the enhancement of immunostimulation were studied. Using low concentrations of sera deficient in various complement (C) components and low concentrations of antibody no augmentation of immunostimulation was seen with Clr-deficient human serum, C2-deficient human serum, C2,4-deficient human serum, C4-deficient guinea pig serum, C3-C9-depleted guinea pig serum (by administration of cobra venom factor to animals), but stimulation was observed with C5-deficient human serum, C5-deficient mouse serum, and C6-deficient rabbit serum. When the concentration of anti-serum was raised, however, augmentation was observed with C4-deficient guinea pig serum. Thus, at low concentrations of antiserum enhancement appeared to occur through the classical C pathway, whereas at high concentrations of antibody either the classical or alternate C pathways appeared to be involved. Stimulation was specifically restored by purified C2 in C2-deficient serum and by C3 in C3-C9-deficient serum. Under the usual reaction conditions consumption of guinea pig C component C4 could be demonstrated which provided direct evidence for activation of the classical C pathway under conditions leading to immunostimulation. By immunofluorescence, cells treated with antibody and normal human serum had human C3 deposited at the cell surface. Taken together these observations suggest that C activated through C3 by either the classical or alternate pathways has the potential to enhance nucleoside incorporation into DNA and cell growth of cells exposed to limiting amounts of antibody. Although the mechanism of stimulation is unknown, it is likely to involve a direct effect of C3 at the level of the cell membrane.
Carcinoma of the Gallbladder
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dermatologische Wochenschrift, Leipzig
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
National Bone Marrow Donor Registry to Begin Recruiting in General Population This Summer
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PATH-49. GENOMIC ATTRIBUTES OF TUMOR EVOLUTION AND TREATMENT RESPONSE IN DIFFUSE GLIOMA
Authors: Andrew Lin, Philip Jonsson, Shahiba Ogilvie, Shweta Chavan, Craig Nolan, Igor Gavrilovic, Thomas Kaley, Christian Grommes, Elena Pentsova, Eli Diamond, Mariza Daras, Jacqueline Stone, Lisa DeAngelis, Viviane Tabar, Cameron Brennan, Robert Young, Marc Rosenblum, Barry Taylor, Ingo Mellinghoff
Journal: Neuro-Oncology (2018)

Though the genomic landscape of primary gliomas has been well characterized by The Cancer Genome Atlas, the genetic determinants of malignant transformation and response to therapy remains poorly understood. Prospective clinical sequencing was performed on 1,004 gliomas from 923 patients. This dataset includes primary and recurrent tumors and contains detailed clinical annotation, including review of the patients imaging. We investigated the germline and somatic attributes of IDH1/2-wildtype and IDH1/2-mutant tumors at the time of diagnosis and recurrence. 13% of patients harbored either a pathogenic or likely pathogenic germline mutation, whereof 29% arose in genes mediating DNA repair. In astrocytomas, agnostic of IDH status, cell cycle alterations were depleted in low-grade tumors. Moreover, mutations in effectors of the cell cycle were associated with the development of enhancing disease in IDH-mutant astrocytomas but not oligodendrogliomas. IDH-mutant astrocytomas with a cell-cycle alteration have a significantly shorter progression-free survival from recurrence compared to tumors without a cell cycle alteration (median 2.5 vs. 35.3 months, HR 3.25, log-rank p-value 0.00061). Based on our data, hypermutation appears to occur exclusively in the context of pre-existing cell cycle alterations in astrocytic tumors, regardless of IDH status. We next correlated molecular findings with clinical behavior and treatment response and defined subsets of gliomas that are uniquely susceptible to targeted treatment and have a differential prognosis. Cell-cycle alterations are lineage-specific alterations associated with aggressive disease in glioma. Targeted genomic sequencing can identify subsets of tumors with a greater sensitivity to treatment and a better prognosis.
Editorial Note
Authors: Herbert Weiner, Adolf-Ernst Meyer, W. Senf, H. Kordy, M. von Rad, W. Bräutigam, Peter E. Sifneos, Cairns Aitken, Chase Patterson Kimball, Alec Ramsay, Michael von Rad, Johannes Siegrist, Adolf-Ernst Meyer, Herbert Weiner, Adolf-Ernst Meyer, Hubert Speidel, W. Bräutigam, M. von Rad, Adolf-Ernst Meyer, Antje Haag, Christian Müller, Volker Tschuschke, Walter Volk, Reinhard Költzow, Fritz A. Muthny, Adam J. Krakowski, A. Heerlein, G. de la Parra, S. Aronsohn, F. Lolas, W. Ehlers, D. Czogalik, E. Gaus, M. Klingenburg, K. Köhle, Hertha Appelt, Bernhard Strauss, K.W. Bash, Hans-Werner Künsebeck, Wolfgang Lempa, Hellmuth Freyberger, Eike G. Fischer, Nora E. Falke, Antje Haag, Adam J. Krakowski, M.A. Rea, D.H. Hellhammer
Journal: Psychotherapy and Psychosomatics (1984)
Disseminated<i>Scopulariopsis brevicaulis</i>infection in an allogeneic stem cell recipient: case report and review of the literature
Authors: A. Salmon, A. Debourgogne, M. Vasbien, L. Clément, J. Collomb, F. Plénat, P. Bordigoni, M. Machouart
Journal: Clinical Microbiology and Infection (2009)
Abstract 845: c-MET nuclear transportation via membrane-bounded retrograde trafficking in breast cancer cells
Authors: Mei-Kuang Chen, Yi Du, Linlin Sun, Jennifer L. Hsu, Yu-Han Wang, Yuan Gao, Jiaxing Huang, Mien-Chie Hung
Journal: Cancer Research (2019)

Abstract Reactive oxygen species (ROS) can be induced by anti-cancer treatments, such as ionizing irradiation and chemotherapy drugs. Hydrogen peroxide (H2O2) is one of the ROS species highly produced in cancer cells due to rapid proliferation or anti-cancer treatments. ROS serve as important intracellular messengers in cell growth and proliferation signaling pathways. However, ROS also causes cellular stress in cancer cells through oxidizing DNA, protein and lipids. Therefore, balancing ROS stress between signaling and damages at a tolerable level is important for cancer cell survival. c-MET is one of the receptor tyrosine kinases overexpressed in breast cancer. Full-length c-MET is known to be oncogenic for triggering signal transduction cascade from plasma membrane to upregulate cell proliferation and migration in cancer cells. Moreover, c-MET is reported to phosphorylate PARP1 under H2O2 stimulation, and the phosphorylated PARP1 resulting in PARP inhibitor resistance in breast cancer cells. However, it is not yet clear how c-MET travels from cell membrane to the nucleus. Here, we demonstrate that H2O2 induces retrograde transport of c-MET from plasma membrane into the nucleus and that knocking down either COPI or Sec61β attenuates H2O2-induced full-length nuclear c-MET accumulation. However, c-MET kinase inhibitor did not block the nuclear transport of c-MET, suggesting the transportation mechanisms is independent from kinase activity. Our results indicate that membrane-bound retrograde vesicles involve in membrane-to-nucleus transportation of c-MET in breast cancer cells. Moreover, nuclear c-MET interacts with both PARP1 and Ku proteins in breast cancer cells, suggesting the role of full-length nuclear c-MET in mediating repair of ROS-induced DNA damages. Citation Format: Mei-Kuang Chen, Yi Du, Linlin Sun, Jennifer L. Hsu, Yu-Han Wang, Yuan Gao, Jiaxing Huang, Mien-Chie Hung. c-MET nuclear transportation via membrane-bounded retrograde trafficking in breast cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 845.