tbuckley/cabot-search huggingface dataset:
DIRECT BLOOD TRANSFUSION APPARATUS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Saskatchewan Dispute
Authors: G. W. Korn
Journal: BMJ (1962)

<h3>Abstract</h3> Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide gene by short or long sleep duration interaction analyses on four BP traits (systolic BP, diastolic BP, mean arterial pressure, and pulse pressure) across five ancestry groups using 1 degree of freedom (1df) interaction and 2df joint tests. Primary multi-ancestry analyses in 62,969 individuals in stage 1 identified 3 novel loci that were replicated in an additional 59,296 individuals in stage 2, including rs7955964 (<i>FIGNL2/ANKRD33</i>) showing significant 1df interactions with long sleep duration and rs73493041 (<i>SNORA26/C9orf170</i>) and rs10406644 (<i>KCTD15/LSM14A</i>) showing significant 1df interactions with short sleep duration (P<sub>int</sub> &lt; 5×10<sup>−8</sup>). Secondary ancestry-specific two-stage analyses and combined stage 1 and 2 analyses additionally identified 23 novel loci that need external replication, including 3 and 5 loci showing significant 1df interactions with long and short sleep duration, respectively (P<sub>int</sub> &lt; 5×10<sup>−8</sup>). Multiple genes mapped to our 26 novel loci have known functions in sleep-wake regulation, nervous and cardiometabolic systems. We also identified new gene by long sleep interactions near five known BP loci (≤1Mb) including <i>NME7, FAM208A, MKLN1, CEP164</i>, and <i>RGL3/ELAVL3</i> (P<sub>int</sub> &lt; 5×10<sup>−8</sup>). This study indicates that sleep and primary mechanisms regulating BP may interact to elevate BP level, suggesting novel insights into sleep-related BP regulation.
"OPERATED."
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Felix Hoppe-Seyler (1825-1895) physiological chemist
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Twelve Students Receive Research Fellowship Awards
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mitotic disturbances and micronucleus induction in Syrian hamster embryo fibroblast cells caused by asbestos fibers.
Authors: E Dopp, J Saedler, H Stopper, D G Weiss, D Schiffmann
Journal: Environmental Health Perspectives (1995)

Asbestos and other mineral fibers have long been known to induce lung cancer and mesothelioma. However, the primary mechanisms of fiber-induced carcinogenesis still remain unclear. We investigated the occurrence of mitotic disturbances induced by asbestos (amosite, crocidolite, chrysotile) in an in vitro approach using Syrian hamster embryo (SHE) fibroblast cells. The following endpoints were investigated: micronucleus formation as a result of mitotic disturbances and characterization of the induced micronucleus population by kinetochore staining and visualization of the spindle apparatus. Supravital UV-microscopy was used to analyze changes in interphase chromatin structure, impaired chromatid separation, and blocked cytokinesis. All three asbestos fiber types induced a high frequency of micronucleus formation in SHE cells (&gt; 200/2000 cells) in a dose-dependent manner (0.1-5.0 micrograms/cm2), with a maximum between 48 hr and 66 hr exposure time. At higher concentrations (more than 5.0 micrograms/cm2) the micronucleus formation decreased again as a result of increased toxicity. Kinetochore staining of micronuclei revealed that 48 +/- 2% of asbestos-induced micronuclei reacted positively with CREST (antikinetochore) serum. Furthermore, spindle apparatus deformations occurred in cells with disturbed metaphases and anaphases, while the spindle fiber morphology appeared unchanged. Our results show that asbestos fibers may cause both loss and breakage of chromosomes in the absence of direct interaction with spindle fibers.
Use of English.
Journal: BMJ (1971)

of electronic automatic counters has com- pletely altered this, for they can count many thousands of cells in a few seconds.The Coulter Model "S" counts approximately 18,000 cells in each of three replicate channels in four seconds.These three replicate counts correspond closely and the inherent error should be only a fraction of that of counts done visually.Automatic cell counters may introduce a number of errors of their own, such as co- incidence counts, incorrect setting of the threshold of discrimination, or those due to the presence of bubbles in the sample line.Nevertheless the precision now achieved with red cell counts gives the M.C.V. a status that it could not hold previously.(3) Neither the manual nor the automatic
THE NEGRI BODIES.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Granulocyte Transfusion
Authors: JAMES ATKINS
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 January 1983Granulocyte TransfusionJAMES ATKINS, M.D.JAMES ATKINS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-1-114_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a recent article Winston and colleagues (1) describe their study as a "prospectively randomized, controlled study." Several of their points seem to need additional comments. First, with regard to the patient characteristics, why were the numbers of patients in the treatment and control groups with acute myelogenous (p =0.18) and acute lymphocytic leukemia (p =0.01) so different? What would be the effect of removing the patients with acute lymphocytic leukemia from the analysis? Did the fact that one group had more acute lymphocytic leukemia patients give that group a response advantage or disadvantage? These questions also...Reference1. WINSTONHOGALE DWR. Therapeutic granulocyte transfusion for documented infections: a controlled trial in ninety-five infectious granulocytopenia episodes. Ann Intern Med. 1982;97:509-15. LinkGoogle Scholar1. WINSTONHOGALE DWR. Therapeutic granulocyte transfusions for documented infections: a controlled trial in ninety-five infectious granulocytopenic episodes. Ann Intern Med. 1982;97:509-15. LinkGoogle Scholar1. WINSTONHOGALE DWR. Therapeutic granulocyte transfusions for documented infections. Ann Intern Med. 1982;97:509-19. LinkGoogle Scholar2. GRAWHERZIGPERRYHENDERSON RGSE. Normal granulocyte transfusions therapy: treatment of septicemia due to gram-negative bacteria. N Engl J Med. 1972;287:367-71. CrossrefMedlineGoogle Scholar3. HERZIGHERZIGGRAWBULLRAY RGRMK. Successful granulocyte transfusion therapy for gram-negative septicemia. N Engl J Med. 1977;296:701-5. CrossrefMedlineGoogle Scholar4. HIGBYYATESHENDERSONHOLLAND DJEJ. Filtration leukapheresis for granulocyte transfusion therapy. N Engl J Med. 1975;292:761-6. CrossrefMedlineGoogle Scholar5. VOGLERWINTON WE. A controlled study of the efficacy of granulocyte transfusions in patients with neutropenia. Am J Med. 1977;63:548-55. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNurse-led education sets out to improve patient concordance and prevent recurrence of leg ulcers 1 January 1983Volume 98, Issue 1Page: 114-114KeywordsGranulocytesPatientsPrecursor cellsProspective studies Issue Published: 1 January 1983 PDF downloadLoading ...
FRIDAY 17TH SEPTEMBER
Journal: Gut (1993)

INTRODUCTON: De-Nol tab (tripotassium dicitrato bismuthate) is used for eradicating l.UY10f.but bismuth (Bi), which is potentially neurotoxic, is absorb lly, therapeutic Bi should not be absorbed, be well tolerated and still OradicatekH.Yloyi.We have studied whether Roter (Bi subnit c e complex; Boots Healthcare) fulfils these criteria.METHODS:a) Five healthy voluntes were given either two De-Noltab (214mg Bi) or one Roter tablet (205mg Bi) and a a week, the other preparation.Blood and urne w by ICP mass spectrometry.kvlori status was asd with C ua breath tests.b) Mean Inhibitory Concentrations (MICs) for De- Noltab and Roter were obtained i in vitro cultures using ten strains of H,.DY)QrL C) Thirty H.vlori positive patients diagnosed by two antral rapid urease tests (CLO test) were given either two De-Noltab bd or two Roter tablets tds for one month both with amoxycillin 250mg tds and metronidazole 400mg tds for one week.CLO tsts were reeated four weeks after treatment.RESULTS: a) Peak blood Bi levels occurred thirty minutes after taking two De-Noltab (range 4.2 -80pg/l, median 56.4 g/l).There was also a wide range in 4 hour Bi unnary excretion 87.2 -1905%g (median 1065.5,sg).Following Roter there was no evidence of B absorotion.There was no correlation between Bi absorption and H.±vrori status.When De-Noltab was given first baseline Bi in bl and urine was still elevated after one week.b) MIC: De-Noltab < 12.5yig/ml; Roter >400A /ml.c) H.lori eradication rates: De-Noltab 7/15 (46.6%)Roter 9/14 (64.3%).One patient on Roter did not attend follow-up gastroscopy.CONCLUJSIONS: There is an unexplained wide range of Bi absorption from De-Noltab (0.04 -0.9W of that ingested excreted in urine).Bi is not absorbed from Roter.Both eradication regimes were well tolerated.Although the MIC for Roter is high in vivo eradication was equal or greater than for De-Noltab.Eradioion rates may be low compared to other studies, perhaps due to high levels of metronidazole resistance in our 1ocal population.Further tWials using Roter are needed.T178
A ball in the eye.
Authors: A Singh
Journal: BMJ (1973)

19Sthat some will always leach out into fluids stored or run through such plastics.What is needed is an ester of low innate toxicity such as DEHP but one for which hydrolytic esters are fairly widespread in nature.Then amounts injected into patients will not accumulate and the larger quantities from industrial waste will be rapidly degraded when they enter sewage systems.
Calcium channel blockers in myocardial infarction.
Journal: BMJ (1990)

SIR,-Dr Peter Held and colleagues' concluded that calcium blockers cannot be recommended for routine use to patients with acute myocardial infarction to reduce death and reinfarction.Results from the Danish verapamil infarction trial I (DAVIT I)2 were included, but the results from the Danish pilot study'4 were not.From the overview the reader who does not know DAVIT I might get a wrong impression of the design and outcome of that trial.We intended to treat patients admitted with acute myocardial infarction with verapamil or placebo for six months after admission.We knew that 40-50% of the patients admitted to coronary
Epidemiologic Assessment of the Impact of Four Hurricanes—Florida, 2004
Journal: JAMA (2005)

Florida experienced four major hurricanes: Charley and Frances (both Category (4) and Ivan and Jeanne (both Category 3).*An estimated 20% of homes throughout Florida were damaged by these hurricanes, 1 and 124 persons died. 2 In October 2004, the Florida Department of Health (FDOH) added 30 questions to the Behavioral Risk Factor Surveillance System (BRFSS) survey to assess the impact of the hurricanes on state residents.This report summarizes the results of that survey, which indicated that 48.7% of Florida residents had no evacuation plan before any of the hurricanes, portable generators were used in 17.5% of homes after electric power outages, and residents of counties not in the direct paths † of the four hurricanes had consequences similar to those who lived in the direct paths of the hurricanes (e.g., physical injuries, barriers to medical treatment, and loss of work days).Public health officials should consider the needs of residents both in and not in the direct paths of hurricanes in their preparedness planning.BRFSS is a state-based, random-digitdialed telephone survey of the noninstitutionalized U.S. population aged Ն18 years. 3During November-December 2004, interviews were conducted with 1,706 Florida residents.Among the participants, 919 (53.9%) lived in the 41 counties in the direct path of at least one of the four hurricanes, and 787 (46.1%) lived in the 26 counties not in the direct paths of the hurricanes; participants represented all 67 counties in Florida.Chi-square tests were used to examine differences in
Phase 1 trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: A North American Brain Tumor Consortium study
Authors: Michael D Prados, W K A Yung, Kurt A Jaeckle, H Ian Robins, Minesh P Mehta, Howard A Fine, Patrick Y Wen, Timothy F Cloughesy, Susan M Chang, M Kelly Nicholas, David Schiff, Harry S Greenberg, Larry Junck, Karen L Fink, Kenneth R Hess, John Kuhn
Journal: Neuro-Oncology (2004)

This study was conducted to determine the maximum tolerated dose and dose-limiting toxicity of irinotecan (CPT-11) administered every 3 weeks to adults with progressive malignant glioma who were treated with enzyme-inducing antiepileptic drug (EIAED) therapy, and to compare the pharmacokinetics with those in patients not on EIAED therapy treated at the recommended phase 2 dose for other cancers. The CPT-11 dose was 350 mg/m2 i.v. every 3 weeks and remained fixed in patients not on EIAED therapy, but the dose was escalated by 50-mg/m2 increments in patients on EIAED therapy. CPT-11 and its metabolites SN-38, SN-38 glucuronide (SN-38G), and APC (7-ethyl-10[4-N-(5 aminopentanoic acid)-1-piperidine]carbonyloxycamptothecin) were characterized in both groups. Patients on EIAEDs received 350 to 800 mg/m2 of CPT-11. Dose-limiting toxicity was due to grade 3 diarrhea despite maximal doses of loperamide. The systemic levels of CPT-11, APC, SN-38G, and SN-38 were all lower in the EIAED group. There was a moderate-to-fair relationship between CPT-11 dose and the area under the curve (AUC) for CPT-11 and APC over the dosage range of 350 to 800 mg/m2, but no relationship between CPT-11 dose and the AUC for SN-38 or SN-38G. At the 750-mg/m2 dose, the AUC for CPT-11 (21.6 μg × h/ml) matched the AUC (21.6 μg × h/ml) in the non-EIAED group treated with 350 mg/m2 of CPT-11. We conclude that the recommended phase 2 dose of CPT-11 for patients on EIAEDs is 750 mg/m2 when given every 3 weeks. A phase 2 study of patients with recurrent malignant glioma is ongoing to assess the efficacy of CPT-11 when the dose is stratified according to the use of EIAEDs.
Adverse Reactions After Administration of Indocyanine Green
Authors: Bernard J. Staller
Journal: JAMA (1978)

<h3>To the Editor.—</h3> Sterile indocyanine green (Cardio-Green) has established clinical value in cardiac dye-dilution study, liver function and blood flow determination, and ophthalmic angiography. Early after its introduction, adverse reactions noted in patients with iodide sensitivity were attributed to the solubilizing iodide component of the pharmaceutical product and led to the incorporation of an appropriate warning in the accompanying package insert. Four more recent reactions (including one death) having a temporal relationship to the administration of sterile indocyanine green have been reported to its manufacturer. None of the patients were thought to have received indocyanine green previously. Each reaction was reported from a different institution, and each involved a different lot number of product. In each case the product was reported to have been used promptly after proper reconstitution in doses consistent with currently recommended levels. <h3>Report of Cases.—Case 1.—</h3> A 70-year-old woman who had undergone a radical
Reminiscences of Osler
Authors: W. S. Rankin
Journal: JAMA (1969)

A letter of introduction and an expression of interest from my professor of surgery at the University of Maryland, Dr. Louis McLain Tiffiny, to Dr. Osler in August 1902 opened the way for my entrance into the courses given by Professors Welch and Osler for the scholastic year 1902 and 1903 at the Johns Hopkins Medical School. A part of Osler's course was a general clinic which was given weekly in the large surgical amphitheater. Every seat was usually occupied by junior and senior students and members of the resident staff. Osler sat in a chair near an examining table in the pit of the amphitheater. The patients were brought in and the diagnosis and treatment of their cases discussed. At one of the clinics a patient was brought in on a stretcher. The patient was completely covered with a sheet. The only clinical feature was a noticeably protuberant abdomen.
Clinical Cardiology
Authors: Irwin R. Callen
Journal: JAMA (1980)

This excellent book was published for the first time two years ago. The time elapsed may be regarded as a short period for a new edition, but the volume under review is part of a paperback series the publisher produces as a "Concise Medical Library for the Practitioner and Student," and most of the titles are revised frequently. <i>Clinical Cardiology</i>is one of the most lucid and easily read and understood of all of the general reviews of cardiology. The language is not overpowering, but concise and clear. There are 23 chapters covering all the important topics a medical student, resident, general physician, internist, or other practitioner might wish to review. It is up-to-date, including references from 1978. The book is profusely illustrated, with good correlation between the printed word and the figures, and even includes two-dimensional echocardiography. From the anatomy and physiology of the circulatory system to history-taking and