POS1123 WEAK OPIOIDS AND TREATMENTS WITH ANTICHOLINERGIC PROPERTIES INCREASE BUT ANTIHYPERTENSIVE TREATMENTS DECREASE THE NUMBER OF FALLS IN PATIENTS FOLLOWED FOR KNEE AND/OR HIP OA: ANALYSES OF THE KHOALA COHORT
Authors: M. Aqlan, M. L. Bocca, G. Loggia, E. Attoh-Mensah, C. Chavoix, A. C. Rat
Journal: Annals of the Rheumatic Diseases (2022)

Background The risk of falling is increased in people with knee osteoarthritis (OA) but the risk factors may not be the same as in the general population. The level of evidence for the associations between the different risk factors and falls in OA is moderate, the number of studies for each factor being small. Objectives The main objective of the study was to identify factors associated with the number of falls in patients with symptomatic knee and/or hip OA during five years of follow-up, in particular the drug-related risk factors that are modifiable factors. Methods This study was based on data from the KHOALA (Knee and Hip OsteoArthritis long term Assessment) cohort, consisting of 878 patients aged 40 to 75 years, with symptomatic knee and/or hip OA, recruited between 2007 and 2009 in the general population. Patients were followed up annually for 10 years. This study is a longitudinal analysis using data from years 5 to 10, with falls data collected from year 5. The primary endpoint was the number of falls reported by the patient. The potential risk factors studied were: medications grouped into ATC classes, a score of treatments with anticholinergic properties*, demographic (age, sex, education, socio-professional category), clinical (comorbidities), perceived health (WOMAC-pain, WOMAC-function, quality of life by the SF-36), and radiological (Kellgren stage) data. Statistical analyses used generalized linear mixed models. Results 661 patients were included in the analyses. The majority of the sample was female (69%); the mean age was 62 years at year 5, and 153 patients (23.15%) had reported one or more falls in the previous 12 months. In multivariate analyses, and thus independent of pain and functional abilities, a significantly higher number of falls was found in women (OR [CI95%] 1.70 [1.12-2.57]), patients living alone (0.65, [0.47-0.95], P=0.02), retired people (1.92, [1.094-3.37]), patients with more comorbidities (OR 1.10, [.01-1.21]), using fewer antihypertensive drugs (OR 0.61, [.42-0.90]), more weak opioids (OR 1.44, [.05-1.96]) and more treatments with anticholinergic properties (OR 1.31, [.00-1.73]) Conclusion Weak opioids and the score of treatments with anticholinergic properties increased, but antihypertensive treatments decreased the number of falls in patients followed for knee and/or hip OA. The risk factors found in this study are identical to those of the general population, whose pain and functional capacities are less impaired. References [1]*Ryan M. Carnahan. The Anticholinergic Drug Scale as a Measure of Drug-Related Anticholinergic Burden: Associations W ith Serum Anticholinergic Activity Journal of Clinical Pharmacology, 2006 Disclosure of Interests Mohammed Aqlan: None declared, Marie-Laure Bocca: None declared, Gilles Loggia: None declared, Elpidio Attoh-Mensah: None declared, Chantal Chavoix: None declared, Anne-Christine Rat Speakers bureau: Pfizer, Lilly, Abbvie, BMS, Galapagos, novartis, Consultant of: Sanofi Genzyme, Lilly, Abbvie, BMS