tbuckley/cabot-search huggingface dataset:
Preventing Fungal Infections in People Who Get Liver Transplants
Journal: Annals of Internal Medicine (1999)

Summaries for Patients16 November 1999Preventing Fungal Infections in People Who Get Liver TransplantsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-10-199911160-00041 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Infection is a major problem for people who get liver transplants. Infections with fungus are a particularly big problem. Fungal infections can be hard to treat and potentially deadly. It may make sense to try to prevent them from happening in the first place.Why did the researchers do this particular study?The researchers wanted to see if giving liver transplant patients an antifungal medication called fluconazole could prevent them from getting fungal infections. They also wanted to make sure that using fluconazole this way would be safe ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Prophylactic Fluconazole in Liver Transplant Recipients. A Randomized, Double-Blind, Placebo-Controlled Trial.” It is in the 16 November 1999 issue of Annals of Internal Medicine (volume 131, pages 729-737). The authors are D.J. Winston, A. Pakrasi, and R.W. Busuttil.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoProphylactic Fluconazole in Liver Transplant Recipients Drew J. Winston , Anita Pakrasi , and Ronald W. Busuttil Metrics 16 November 1999Volume 131, Issue 10Page: 729KeywordsAntifungalsBloodEpileptic seizuresLiverLiver transplantationSkin infectionsSmellSurgeryTaste ePublished: 15 August 2000 Issue Published: 16 November 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.Loading ...
Commentaire du travail de Lee BU et al., pp. 1078
Journal: Endoscopy (2014)

See also: Newly designed, fully covered metal stents for endoscopic ultrasound (EUS)-guided transmural drainage of peripancreatic fluid collections: a prospective randomized studyEndoscopy 2014; 46(12): 1078-1084DOI: 10.1055/s-0034-1390871
Priorities for Increasing Availability of Health Services in Rural Areas
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DR. WYETH'S LIFE OF FORREST.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In this issue
Journal: Journal of Clinical Investigation (2007)

Akt makes melanomas grow downwardEarly-stage melanomas grow superficially in a radial manner and can be treated by surgery.By contrast, advanced-stage melanomas grow vertically, gaining the ability to invade other tissues and metastasize to distant organs, and are usually highly resistant to chemotherapy and radiation.Determining the molecular differences between radial and vertical growth melanomas might provide new targets for the development of drugs to treat individuals with advanced-stage melanoma.In this issue (pages 719-729), Govindarajan and colleagues show that overexpression of Akt in a radial growth human melanoma cell line endows the tumor cells with the ability to grow when transplanted into immunocompromised mice.This ability to grow invasively was associated with increased production of ROS, probably because of the increased number of cells with defective mitochondria and increased expression of the ROS-producing enzyme NOX4.This study therefore indicates that overexpression of Akt alone can convert a radial growth melanoma cell line into a highly invasive tumor cell line, leading the authors to suggest that Akt and the pathways that generate ROS might be good targets for the development of drugs to treat individuals with advanced-stage melanoma.
Correction
Authors: R Phillips, D Van Slyke, V Dole, K Emerson, P Hamilton
Journal: BMJ (1945)

tion of plasma proteins from plasma gravities, and of haemoglobin and haematocrit values from combined plasma and whole blood gravities.The haemoglobin values thus estimated appear, from comparison with precise oxygen capacity determinations, to be as accurate as haemoglobin values determinable by the better types of colorimetric procedures.The haematocrit values are less accurate, but are useful unless blood conditions are present which alter the-specific gravity of the cells.If the blood cells are normal, cell counts also can be estimated from blood and plasma gravities.
Lake-Associated Outbreak of Escherichia coli O157:H7—Illinois, 1995
Journal: JAMA (1996)

On July 5, 1995, the Winnebago County Health Department (WCHD) in northern Illinois received a report from the local hospital of five cases of Escherichia coli O157:H7 infection among children who resided in Rockford. Interviews of the children's parents revealed no common food source; however, on June 24-25, they all had visited an Illinois state park with a lake swimming beach. On July 6, the Illinois Department of Public Health (IDPH) closed the swimming beach because of suspected transmission of infection through lake water. WCHD and IDPH investigated the outbreak to assess risk factors for illness and determine the source of infection. This report summarizes the findings of the investigation, which indicate that ingesting contaminated and untreated lake water can result in infection.
Sulfonamide Resistance Developing During Treatment of Pneumococcic Endocarditis
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diet and heart: a postscript
Authors: Pancras Church, E Olsen, M Turner, E Mcnamara, K Shorten, P Frith, P Ward, D Duchesne, G Anderson, S Bernstein, T Bryant, J Caldwell, M Clark, D Craddock, G Cunningham, J Donald, F Eminson, J Goldman, John Goodhart, P Grob, J Ham, Lilian Harris, R Law, J Mccaldin, J Mcmaster, H Mason, M O'sullivan, J Price, D Ratcliffe, B Reiss, E Robinson, Elizabeth Rose, J Rose, K Scott, Katalin Schopflin, Joan Sutherland, J Walker, W Waters, L_ White, J White, H Young, J Zidell, M Linnett, M Macg, C Waine, R Abraham, N Achar, A Agius-Ferrante, T Akintewe, G Ali, G Al-Rawi, Y Al-Saaty, R Angunawela, L Archer, S Ashraf, J Ayres, A Azzam, I Bandak, Lynn Banna, A Barat, D Bareford, M Barry, E Bateman, P Blake, N Boon, L Borysiewicz, M Brooks, A Brown, I Brown, C Campbell, V Carpy, S Chakrabarti, C Chan, Elizabeth Chang, C Chee, S Cheong, H Chong, F Chong, A Chu, W Chung, Anne Cockcroft, D Collas, C Costalos, S Court, Benvon Cramer, R Cranfield, A Crisp, D Cutting, A Dallev, P Dar, G Davies, D Dawkins, J Deanfield, Dc Silva, P Dhillon, J Dick, P Doogan, P Dryburgh, M Silva, A Dunbar, J Evans, M Farage, J Fasler, A Fenech, K-C Fok, J Foster, R Foulds, G Fowler, A Fraser, Christine Fraser- Moodie, R Galbraith, B Gatee, A Gatrad, M Ghouri, J Gibbs, J Gibson, Juliet Gould, D Graham-Brown, J Green, S Mgrimmer, M Gunawardena, D Gunawardena, I Hamilton, F Hannigan, R Harris, T Hay, J Hay, A Henderson, A Hewazy, J Hewitt, Elaine Hicks, C Higgens, A Hill, S Hillier, J Hobbiss, R Holmes, T Hong, G Hope, C Hui, P Hurst, C Jackson, M Jaffery, Jayaram Rai, D Jaya- Sekera, L Jayasinghe, M Johnson, B Jones, P Jones, R Jones, Lesley Kay, Janice Kohler, Mildred Kulasekaram, P Kunju, A Kuti, L F-M Lai, C Laing, R Lee, S Lee, Alison Leiper, J Leonard, T-C Leung, K Liew, Lorraine Linton, R Livingstone, I Low, J Lowes, A Mackay, M Mcmillan, W Mcnabb, G Madhav, Z Mahdi, A Main, R Mariwalla, Linda Marks, Roseda Marshall, C Martin, M Maskill, A Matheson, Margaret Mathieson, R Matthews, Z Mehdi, R Mehta, W Melia, R Melsom, I Melville, S Mendis, G Miller, P Mistry, Z Mistry, J Morgan, J Moriarty, Margaret Muddiman, M Mukunyandela, S Murdoch, Ruth Murgatroyd, O Narayanan, L Nagrani, M Nasar, V Natarajan, R Newton, A Nicholls, R Nightingale, E Nielesani, R Num, P O'connor, M Okleh, P F B O'regan, M Otterburn, K Palmer, P Payne, M Perkins, J Pickvance, R Poulter, G Powell, M Preston, Margaret Price, R Prior, Ragupathy Renganathan, R Rashid, J Reid, B Renton, I Richardson, P Robson, J Rowley, A Rozkovec, J Russell, P Sainsbury, Marcia Sandler, Elzbieta Sawicka, I Scobie, J Scott, M Seervai, V Sharma, D Shiers, I Short, J Shribman, A Silas, Claire Sillince, G Sing, Singaraveloo Muthusamy, G Skowronski, L Sly, V Sood, R Spiller, V Stanley, N Statham, R Stocks, J Stokes, G Supramaniam, M Q-E-K Talukder, J Taylor, M Taylor, King Tiong, J Tooke, G Van Hazel, R Van Zyl-Smit, P Varma, Katherine Venables, Margaret Wallington, J Walters, C Walton, Janine White, P Wilev, M Wilkinson, R Willicombe, N Wong, J Wyld, M Ziada
Journal: BMJ (1977)
Cholesterol Screening
Authors: Paul A. Tunick
Journal: Annals of Internal Medicine (1991)

Letters15 December 1991Cholesterol ScreeningPaul A. Tunick, MDPaul A. Tunick, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-12-983_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:Krahn and colleagues (1) compared an aggressive (U.S.) and a less aggressive (Canadian) policy for cholesterol screening and treatment, and concluded that the results of both approaches were comparable and that identifying patients with abnormalities and subjecting them to physician visits and treatment was a disadvantage of treatment. Although these conclusions may well be correct, it is also possible to draw a different conclusion, namely, that even the "aggressive" approach is too conservative. The 17% or so reduction in cholesterol that has been reported with dietary counseling and drug therapy is relatively modest, and much more dramatic...Reference1. KrahnNaylorBasinskiDetsky MDAA. Comparison of an aggressive (U.S.) and a less aggressive (Canadian) policy for cholesterol screening and treatment. Ann Intern Med. 1991;115:248-55. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York University Medical Center New York, NY 10016 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCholesterol Screening 15 December 1991Volume 115, Issue 12Page: 983-983KeywordsCholesterolDrug therapy Issue Published: 15 December 1991 PDF DownloadLoading ...
Cyanocobalamin injections for patients without documented deficiency. Reasons for administration and patient responses to proposed discontinuation
Authors: L. Lawhorne
Journal: JAMA (1989)

We reviewed the records of 1222 patients who attended a newly acquired rural satellite clinic and found that 120 (10%) had been receiving regular cynocobalamin injections, but that only 4 (3%) met accepted criteria for its administration. Open-ended interviews with 48 of these patients revealed that they had been receiving cyanocobalamin injections for a mean of 9.9 years for 3.3 symptoms each and with a mean effectiveness rating of 2.9 (scale, 0 to 4). After receiving education regarding the appropriate indications for cyanocobalamin injections, 25 (52%) of the patients were willing to stop receiving them at least temporarily. However, 18 patients (38%) who were younger and who reported greater symptom relief would actively seek a physician who would continue to administer cyanocobalamin. Our findings suggest that some patients who have been receiving cyanocobalamin injections but who do not have a documented deficiency will stop receiving the injections when presented with reasonable alternatives. (<i>JAMA</i>. 1989;261:1920-1923)
Final STEPP results of prophylacatic versus reactive skin toxicity (ST) treatment (tx) for panitumumab (pmab)-related ST in patients (pts) with metastatic colorectal cancer (mCRC)
Authors: E. P. Mitchell, M. Lacouture, H. Shearer, N. Iannotti, B. Piperdi, M. Pillai, F. Xu, M. Yassine
Journal: Journal of Clinical Oncology (2009)

CRA4027
Bone marrow–derived progenitor cells in pulmonary fibrosis
Authors: Naozumi Hashimoto, Hong Jin, Tianju Liu, Stephen W. Chensue, Sem H. Phan
Journal: Journal of Clinical Investigation (2004)

The origin of fibroblasts in pulmonary fibrosis is assumed to be intrapulmonary, but their extrapulmonary origin and especially derivation from bone marrow (BM) progenitor cells has not been ruled out. To examine this possibility directly, adult mice were durably engrafted with BM isolated from transgenic mice expressing enhanced GFP. Induction of pulmonary fibrosis in such chimera mice by endotracheal bleomycin (BLM) injection caused large numbers of GFP+ cells to appear in active fibrotic lesions, while only a few GFP+ cells could be identified in control lungs. Flow-cytometric analysis of lung cells confirmed the BLM-induced increase in GFP+ cells in chimera mice and revealed a significant increase in GFP+ cells that also express type I collagen. GFP+ lung fibroblasts isolated from chimera mice expressed collagen and telomerase reverse transcriptase but not α-smooth muscle actin. Treatment of isolated GFP+ fibroblasts with TGF-β failed to induce myofibroblast differentiation. Cultured lung fibroblasts expressed the chemokine receptors CXCR4 and CCR7 and responded chemotactically to their cognate ligands, stromal cell–derived factor-1α and secondary lymphoid chemokine, respectively. Thus the collagen-producing lung fibroblasts in pulmonary fibrosis can also be derived from BM progenitor cells.
Failure of phenothiazines in sickle cell anemia
Authors: H. A. Pearson
Journal: JAMA (1967)

A beneficial effect of phenothiazine therapy on clinical symptomatology and red cell survival in patients with sickle cell anemia (hemoglobin SS) has been described by Lewis and Hathorn from Ghana.<sup>1-3</sup>The rationale for this treatment was based on their observations of an apparently higher than expected incidence of red cell (RBC) glucose-6-phosphate dehydrogenase (G<sub>6</sub>PD) deficiency in patients with hemoglobin SS disease when compared to normal individuals. They suggested that the enzyme deficiency might have a beneficial effect on the course of hemoglobin SS disease, thus leading to a preferential survival of those individuals with the combination. Because genetically determined G<sub>6</sub>PD deficiency was postulated to be advantageous, they then undertook treatment with pharmacologic agents which were known to inhibit the enzyme. The phenothiazine promazine (Sparine) hydrochloride inhibits G<sub>6</sub>PD<sup>4</sup>and, in high levels, interferes with in vitro sickling.<sup>1</sup> When promazine hydrochloride, in a
SAN FRANCISCO SESSION
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Doctor in the Night
Authors: Martin C. Rosner
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acquired Immunodeficiency Syndrome: Epidemiology, Virology, and Immunology
Authors: A Weiss
Journal: Annual Review of Medicine (1985)

Acquired Immuno-Deficiency Syndrome: Epidemiology, Virology, and Immunology, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/med/36/1/annurev.me.36.020185.002553-1.gif
Protective Value of Dietary Copper and Iron against Some Toxic Effects of Lead in Rats
Authors: David S. Klauder, Harold G. Petering
Journal: Environmental Health Perspectives (1975)

Both dietary iron and copper were inversely related to lead absorption as indicated by erythrocyte and kidney lead levels, dietary iron having the greatest effect. Kidney copper values were depressed when dietary iron was low, a condition which was worsened by lead. Lead tended to lower heart cytochrome c oxidase especially when dietary copper was low, but also when dietary copper and zinc were high. Lead interfered with hematopoiesis when dietary copper and/or iron were low, the effect being expecially severe when both essential nutrients were low. These results show the importance of copper and iron nutriture and metabolism as factors which reduce lead toxicity, and emphasize the necessity of considering nutritional status in evaluating lead toxicity.
Cell membrane defects in mental illness
Authors: B. Merz
Journal: JAMA (1982)

The cell membrane, rather than the chromosomes, may be the place to look for biological markers of bipolar depressive disease (commonly known as manic-depressive illness), according to research conducted at the University of Texas Health Science Center at Dallas (UTHSCD) and at Northwestern University Medical School in Chicago. Both studies, though unrelated, have detected functional abnormalities in cell membranes that distinguish—with a high degree of accuracy—cells of patients with bipolar depression from those of other persons sampled. The UTHSCD team, directed by neurologist Jay Pettegrew, MD, reported 100% success in distinguishing the cells of 20 persons with previously diagnosed bipolar depression from those of 20 normal persons. Pettegrew describes the investigation, which he conducted with John Nichols, PhD, Nancy Minshaw, MD, John Rush, MD, and Malcolm Stewart, MD, in the<i>Journal of Affective Disorders</i>(in press). In the study, intact living lymphocytes, RBCs, and fibroblasts were analyzed within an hour