tbuckley/cabot-search huggingface dataset:
Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion
Authors: Yi Sun, Tyler J. Florio, Sagar Gupta, Michael C. Young, Quinlen F. Marshall, Samuel E. Garfinkle, Georgia F. Papadaki, Hau V. Truong, Emily Mycek, Peiyao Li, Alvin Farrel, Nicole L. Church, Shereen Jabar, Matthew D. Beasley, Ben R. Kiefel, Mark Yarmarkovich, Leena Mallik, John M. Maris, Nikolaos G. Sgourakis
Journal: Science Immunology (2023)

Peptide-centric chimeric antigen receptors (PC-CARs) recognize oncoprotein epitopes displayed by cell-surface human leukocyte antigens (HLAs) and offer a promising strategy for targeted cancer therapy. We have previously developed a PC-CAR targeting a neuroblastoma-associated PHOX2B peptide, leading to robust tumor cell lysis restricted by two common HLA allotypes. Here, we determine the 2.1-angstrom crystal structure of the PC-CAR–PHOX2B–HLA-A*24:02–β 2 m complex, which reveals the basis for antigen-specific recognition through interactions with CAR complementarity-determining regions (CDRs). This PC-CAR adopts a diagonal docking mode, where interactions with both conserved and polymorphic HLA framework residues permit recognition of multiple HLA allotypes from the A9 serological cross-reactive group, covering a combined global population frequency of up to 46.7%. Biochemical binding assays, molecular dynamics simulations, and structural and functional analyses demonstrate that high-affinity PC-CAR recognition of cross-reactive pHLAs necessitates the presentation of a specific peptide backbone, where subtle structural adaptations of the peptide are critical for high-affinity complex formation, and CAR T cell killing. Our results provide a molecular blueprint for engineering CARs with optimal recognition of tumor-associated antigens in the context of different HLAs, while minimizing cross-reactivity with self-epitopes.
Early Peripheral Blood Blast Clearance As a Prognostic Marker for Early Treatment Response in Pediatric Acute Myeloid Leukemia
Authors: Noa E. Wijnen, Bianca de Boer, Kim Klein, Jonas Abrahamsson, Barbara De Moerloose, Bernward Zeller, Henrik Hasle, Zhanna Kovalova, Nira Arad-Cohen, Gertjan J.L. Kaspers
Journal: Blood (2023)
Ex-Vivo Testing Platform to Predict Clinical Response and Resistance to Proteosome Inhibitors, IMiDs and Daratumumab in Multiple Myeloma
Authors: Constanza Marin, Maribel Nicola, Diego Andino, Maria Laura Bernaschini, Agustina Conrrero, Gimena Ferreira, Marisa Piaggio, Guillermina Remaggi, Maria Sol Jarchum, Gustavo Jarchum, Rodrigo Meneces Bustillo, Blanca de los Milagros Rossi, Juan José García, Tarek Ali Zaki, Candelaria Llorens, Gerardo Gatti, Daniela Arroyo, Gastón Soria
Journal: Blood (2023)
Relapse Incidence Post Unrelated Allogeneic Stem Cell Transplantation with Post-Transplant Cyclophosphamide (PTCy) Versus Conventional Anti-Graft Versus Host Disease Prophylaxis in Patients with Acute Myeloid Leukemia: A Study on Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Authors: Arnon Nagler, Maud Ngoya, Jacques-Emmanuel Galimard, Myriam Labopin, Igor Wolfgang Blau, Nicolaus Kröger, Tobias Gedde-Dahl, Thomas Schroeder, David Burns, Urpu Salmenniemi, Alessandro Rambaldi, Goda Choi, Regis Peffault De Latour, Jan Vydra, Henrik Sengeloev, Matthias Eder, Stephan Mielke, Edouard Forcade, Sergey Bondarenko, Fabio Ciceri, Mohamad Mohty
Journal: Blood (2023)
Novel Insights in TKI Resistance in <i>BCR</i>:: <i>ABL1</i>-Positive B-Cell Acute Lymphoblastic Leukemia Beyond Kinase Domain Mutations
Authors: Inge Van Outersterp, Caitlin E.J. Reichert, Aurelie Boeree, Cesca Van De Ven, Brian Kruisinga, Hester A. de Groot-Kruseman, Gabriele Escherich, Anita W. Rijneveld, Judith M. Boer, Monique L. den Boer
Journal: Blood (2023)
Transcriptional Co-Activator P300 Promotes Extra-Medullary Disease Formation and Myeloma Disease Progression
Authors: Rajib Shome, Srikanth Talluri, Tsuyoshi Fukushima, Mehmet K. Samur, Rie Nakamoto-Matsubara, Cristina Panaroni, Keertik Fulzele, Kiyosumi Ochi, Ryan Seongmin Han, Farah Rexha, David Scadden, Nikhil C Munshi, Noopur S. Raje
Journal: Blood (2023)
Prediction of Sinusoidal Obstructive Syndrome after Allogeneic Stem Cell Transplantation Using Liver Stiffness Measurement By Fibroscan
Authors: Ivetta Danylesko, Yana Davidov, Noga Shem-Tov, Ronit Yerushalmi, Ziv Ben-Ari, Arnon Nagler, Avichai Shimoni
Journal: Blood (2023)
Management and Evolution after VTE Recurrence and/or Bleeding in Cancer Patients Receiving Anticoagulant Therapy for VTE: A Nationwide Cohort Study in France
Authors: Isabelle Mahe, Gaelle Gusto, Nadia Quignot, Artak Khachatryan, José Chaves, Audrey Moniot, Lucas André, Sylvain Van Roy, Ruth Mokgokong, Laurent Bertoletti
Journal: Blood (2023)
The Effect of Concizumab Prophylaxis on Target Joints, Resolution and Joint Bleeds in Patients With Hemophilia A or B With or Without Inhibitors in Phase 3 Clinical Trials
Authors: Giancarlo Castaman, Aby Abraham, Pantep Angchaisuksiri, Laura Villarreal Martinez, Keiji Nogami, Jameela Sathar, Chunduo Shen, Jay Jay Thaung Zaw, Guy Young
Journal: Blood (2023)
PD-1 Antibody (Sintilimab) Plus Histone Deacetylase Inhibitor (Chidamide) for the Treatment of Refractory or Relapsed Extranodal Natural Killer/T Cell Lymphoma, Nasal Type (r/r ENKTL): Updates of the Phase Ib/II Scent Study
Authors: Gao Yan, Liling Zhang, Wenyu Li, Xu Wei, Ru Feng, Xue-Ping Li, Yu Chen, Huijing Wu, Xiaoxiao Wang, Bing Bai, Huiqiang Huang
Journal: Blood (2023)
Impact of Conditioning Intensity and Regimen on Outcomes after Unrelated Cord Blood Transplantation for Patients with Myelodysplastic Syndrome
Authors: Machiko Fujioka, Hidehiro Itonaga, Yasushi Miyazaki, Yoshimitsu Shimomura, Naoyuki Uchida, Satoshi Takahashi, Makoto Onizuka, Yasunori Ueda, Yasufumi Uehara, Masatsugu Tanaka, Yoshiko Matsuhashi, Shigesaburo Miyakoshi, Haruyuki Tanaka, Toshiro Kawakita, Fumihiko Ishimaru, Junya Kanda, Tatsuo Ichinohe, Yoshiko Atsuta, Ken Ishiyama
Journal: Blood (2023)
Current Results of Intensive Therapy in Younger Adults with Acute Myeloid Leukemia (AML): The Large Randomized French Backbone Intergroup (BIG)-1 Study on Behalf of the Filo, ALFA, and SFGM-TC Study Groups
Authors: Hunault-Berger Mathilde, Cécile Pautas, Sarah Bertoli, Pierre-Yves Dumas, Emmanuel Raffoux, Tony Marchand, Marie Anne Hospital, Mael Heiblig, Sylvain Chantepie, Martin Carré, Pierre Peterlin, Emilie Lemasle, Célestine Simand, Maria Pilar Gallego Hernanz, Anne Huynh, Edouard Forcade, Raynier Devillier, Stéphanie Nguyen Quoc, Nicolas Duployez, Isabelle Luquet, Dominique Penther, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Gerard Socié, Jean-Yves Cahn, Norbert Ifrah, Norbert Vey, Regis Peffault De Latour, Eric Delabesse, Claude Preudhomme, Jean-François Hamel, Arnaud Pigneux, Christian Recher, Hervé Dombret
Journal: Blood (2023)
Functional Testing of Variants of Uncertain Significance in <i>TERC, TERT</i>,and <i>RTEL1</i> from Adult Patients with Telomere Biology Disorders
Authors: Rachel A Simon, Christy M Finke, Terra L Lasho, Christopher T. Schmitz, Jenna A Fernandez, Eva M Carmona-Porquera, Mark E Wylam, Thomas E. Witzig, Tammy M McAllister, Carolyn R. Rohrer Vitek, Konstantinos N Lazaridis, Abhishek A Mangaonkar, Mrinal M. Patnaik, Alejandro Ferrer
Journal: Blood (2023)
Prolonged Cytopenia Following CAR T-Cell Therapy in Relapsed/Refractory Multiple Myeloma: A Prospective Comprehensive Biomarker Study
Authors: Xiang Zhou, Vivien Wagner, Emilia Stanojkovska, Christine Riedhammer, Xianghui Xiao, Mara John, Lukas Scheller, Umair Munawar, Seungbin Han, Johannes M Waldschmidt, Max S. Topp, Johannes Duell, Hermann Einsele, Angela Riedel, Martin Kortüm, Leo Rasche
Journal: Blood (2023)
Mismatched Unrelated Donor Transplantation with Ptcy-Based Gvhd Prophylaxis Is Associated with Better Survival Than Double Unit Umbilical Cord Blood Transplantation in Patients with AML in First CR: A Study from the ALWP of the EBMT
Authors: Frederic Baron, Myriam Labopin, Jurjen Versluis, Jan Vydra, Peter A. Von Dem Borne, Emma Nicholson, Didier Blaise, Stephen Robinson, Aleksandr Kulagin, Claude-Éric Bulabois, Montserrat Rovira, Patrice Chevallier, Édouard Forcade, Jenny Louise Byrne, Jaime Sanz Caballer, Annalisa Ruggeri, Mohamad Mohty, Fabio Ciceri
Journal: Blood (2023)
Comparative Effectiveness of Ibrutinib Flexible Dosing Treatment Strategies on Time to Next Treatment in a Largely Community-Based Claims Database: A Target Trial Emulation Study
Authors: Nilanjan Ghosh, Ruibin Wang, Zhijie Ding, Jinghua He, Alex Bokun, Heena Mavani, Zaina P Qureshi, Kerry A Rogers
Journal: Blood (2023)
The Battle within: AML´s p53 Strategies to Evade T-Cell Attack
Authors: Lis Winter, Lea Pawlowsky, Anetta Marcinek, Bettina Brauchle, Amelie Muth, Maryam Kazerani, Agnese Petrera, Roman Kischel, Alica Joana Emhardt, Maja Rothenberg-Thurley, Annika Maria Dufour, Karsten Spiekermann, Michael Andreeff, Naval Daver, Veit L. Buecklein, Marion Subklewe
Journal: Blood (2023)
Safety of Crovalimab Versus Eculizumab in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH): Pooled Results from the Phase III COMMODORE 1, COMMODORE 2, and COMMODORE 3 Studies
Authors: Alexander Roeth, Rong FU, Guangsheng He, Hazza A Alzahrani, Sheng-Chieh Chou, Yosr Hicheri, Maciej Kazmierczak, Viviane Lacorte Recova, Michihiro Uchiyama, ANA Maria Vladareanu, Leigh Beveridge, Simon Buatois, Muriel Buri, Dayu Shi, Nadiesh Balachandran, Sasha Srekovic, Phillip Scheinberg
Journal: Blood (2023)
Characteristics of Alloreactive T-Cell Clones That Predict Early Development of Acute GvHD Following Allogeneic HCT
Authors: Ximi Kevin Wang, Ajna Uzuni, Kirubel Belay, David W Harle, Christian A Gordillo, Rodney J Macedo, Shami Chakrabarti, Lingting Shi, Michael Pressler, Joshua Fuller, Elham Azizi, Ran Reshef
Journal: Blood (2023)
Outcome of Infants Treated on Total Therapy for Infants with Acute Lymphoblastic Leukemia I: Results from a Non-Randomized Multi-Center Study
Authors: Tanja A. Gruber, Minxuan Huang, Sima Jeha, Rebecca J. Deyell, Victor A. Lewis, Bill H. Chang, Eric J. Lowe, Jamie Frediani, Catherine Vezina, Bruno Michon, Nathan Gossai, Erin H. Breese, Thai Hoa Tran, Norman J. Lacayo, Christine Bolen, Sunil J. Desai, Jennifer L. Pauley, Emily Ashcraft, Cheng Cheng, Kirk R. Schultz, Krysta Schils, Linda C. Stork, Van Thu Huynh, Michael Richards, Yoav H. Messinger, Henrique Bittencourt, Terzah M. Horton, Uma Athale, Duncan Stearns, Deborah E. Schiff, Paul S. Gaynon
Journal: Blood (2023)
Menin Inhibitor Induced Menin Protein Degradation Contributes to Menin Inhibitor Efficacy
Authors: Jevon Cutler, Jonathan Tsai, Brandon Regalado, Wallace Bourgeois, Daniela Wenge, Jeonghyeon Kim, Radoslaw Nowak, Elizabeth Ener, Katherine Donovan, Sarah Naomi Olsen, Eric Fischer, Benjamin L. Ebert, Scott A Armstrong
Journal: Blood (2023)
Beyond the Primary: Unveiling the Prognostic Value of Secondary Cytogenetic Abnormalities in Multiple Myeloma
Authors: Rodrigo Fonseca, Mariano Arribas, Gregory Ahmann, Janna C Castro, Erin E Wiedmeier-Nutor, Linda Banovic Baughn, P. Leif Bergsagel, Rafael Fonseca
Journal: Blood (2023)
The Area Under Tacrolimus Concentrations on Day 14-28 Is the Independent Predictor of the Development of Chronic Gvhd in Patients without Severe Acute Gvhd after Unrelated Allogeneic HSCT
Authors: Susumu Tanoue, Hiroki Yokoyama, Hiroto Ishii, Daiki Hattori, Iku Kamitani, Takeshi Saito, Shingo Yano
Journal: Blood (2023)
CD33-TIM3 Dual CAR T Cells: Enhancing Specificity While Maintaining Efficacy Against AML
Authors: Yingshuai Wang, Wenjie Lu, Lisa Rohrbacher, Heinrich Flaswinkel, Alica Joana Emhardt, Giulia Magno, Sascha Haubner, Sebastian Kobold, Heinrich Leonhardt, Karl-Peter Hopfner, Dirk H Busch, Veit L. Buecklein, Daniel Nixdorf, Marion Subklewe
Journal: Blood (2023)
Final Results from Phase 1 Study of Briquilimab, an Anti-CD117 Monoclonal Antibody, in Combination with Low Dose Irradiation and Fludarabine Conditioning, Shows Durable Remissions in Older Adults with Acute Myeloid Leukemia in Complete Remission and Myelodysplastic Syndrome Undergoing Allogeneic Hematopoietic Cell Transplantation
Authors: Arpita Gandhi, Andrew Artz, Catherine J. Lee, Ankur Varma, Bart L. Scott, Hye-Sook Kwon, Minyoung Youn, Chikako Yanagiba, Jeyakavitha Arulprakasam, Anne Le, Judith Shizuru, Wendy W Pang, Lori S. Muffly
Journal: Blood (2023)
Loss of Function <i>MBD4</i> Mutation Impairs DNA Repair in Association with TET2 in Acute Myeloid Leukemia
Authors: Naomi Kawashima, Dongxu Jiang, Daniel Vail, Divya Jyoti Singh, Xiaorong Gu, Simon Schlanger, Carmelo Gurnari, Yasuo Kubota, Brittany L Stewart, Valeria Visconte, Jaroslaw P. Maciejewski, Babal K. Jha
Journal: Blood (2023)
Trial in Progress: Treatment of Newly-Diagnosed Follicular Lymphoma with Celmod BMS-986369, Rituximab +/- Nivolumab: An Umbrella Phase II Investigator-Initiated Study
Authors: Geoff Chong, Jodie B Palmer, Allison A Barraclough, Leonid Churilov, Colm Keane, Sze Ting Lee, Denise Lee, Sumita Ratnasingam, Charmaine Smith, Eliza A Hawkes
Journal: Blood (2023)
Final Results of the AIEOP (Associazione Italiana Ematologia/Oncologia Pediatrica) AML 2013 Prospective Randomized Trial in Childhood Acute Myeloid Leukemia (AML)
Authors: Franco Locatelli, Barbara Buldini, Martina Pigazzi, Carmelo Rizzari, Rosanna Cuccurullo, Franca Fagioli, Manuela Tumino, Luca Lo Nigro, Maria Giuseppina Cefalo, Luisa Strocchio, Marco Zecca, Marco Becilli, Andrea Pession, Nicola Santoro, Concetta Micalizzi, Riccardo Masetti, Pietro Merli
Journal: Blood (2023)
Measuring CD8-Positive T-Cells in the Tumor Microenvironment in Classical Hodgkin Lymphoma Using Multiplex Immunofluorescence Staining and Image Analysis: A Possible Prognostic Factor
Authors: Hiromichi Takahashi, Shun Ito, Yoko Nakanishi, Katsuhiro Miura, Masaru Nakagawa, Shimon Otake, Takashi Hamada, Takashi Koike, Kazuhide Iizuka, Yuichi Takeuchi, Kazuya Kurihara, Toshihide Endo, Hironao Nukariya, Yoshihiro Hatta, Shinobu Masuda, Hideki Nakamura
Journal: Blood (2023)
Leukemic Stem Cells (LSCs) As Peri-Transplant MRD Assessment in AML Patients Undergoing Allogeneic Stem Cell Transplantation in CR
Authors: Evgeny Klyuchnikov, Anita Badbaran, Radwan Massoud, Petra Freiberger, Christine Wolschke, Francis A. Ayuk, Ulrike Bacher, Nicolaus Kroeger
Journal: Blood (2023)
Rapid Clinical Mutation Screening for AML Using the Genexus Platform
Authors: Shahanawaz Jiwani, Jerald P. Radich, Maria Saeed, Lauri Aicher, Ting-Chia Chang, Srikrishna Narava, Zaneta Holman, Lan Beppu, Olga Sala-Torra, Marvin Majano, Erin Taylor, Laura Yee, Jessica Li, Lisa McShane, Pooja CS Sanduria, Paul Mickey M. Williams, Cecilia C.S. Yeung
Journal: Blood (2023)
Oncofertility Counseling Practices in Pediatric Hematology/Oncology: Addressing Barriers and Time Pressures
Authors: John Mariano, Hayley Brianne Flanagan, Kimberly H Seymour, Nicole SanGiacomo, Nneka Ogbutor, Arman Niknafs, Brittany Hodges, Adam Evans, Jeffrey R. Andolina
Journal: Blood (2023)
Self-Supporting Human Acute Myeloid Leukemia (AML) Bone Marrow Organoids Established from Patient-Derived Xenografts Mimic the Human AML Microenvironment, with Distinct Cytokine Kinetics Correlating with Dynamic Cell Proliferation and Metabolic Shifts
Authors: Alejandro De Janon, Aashis Thapa, Fang Zhou, Ahmet Coskun, Athanasios Mantalaris, Douglas K. Graham, Deborah DeRyckere, Nicki Panoskaltsis
Journal: Blood (2023)
Label-Free High Dimensional Single Cell Morphological Profiling of Different Hematological Malignancies By Ghost Cytometry
Authors: Asako Tsubouchi, Juho Jalmari Miettinen, Keisuke Wagatsuma, Satoru Akai, Yuri An, Mika Uematsu, Philipp Sergeev, Dimitrios Tsallos, Markus Vaha-Koskela, Sadao Ota, Caroline A. Heckman
Journal: Blood (2023)
The ATF4-RPS19BP1 Axis Modulates Ribosome Biogenesis to Promote Erythropoiesis
Authors: Zhaofeng Zheng, Shangda Yang, Fanglin Gou, Chao Tang, Zhaoru Zhang, Penglei Jiang, Pengxu Qian, Ping Zhu, Hui Cheng, Tao Cheng
Journal: Blood (2023)
Outpatient Management of CAR-T and Teclistamab for Patients with Lymphoma and Multiple Myeloma
Authors: Radhika Bansal, Jonas Paludo, Andre Corraes, Megan Spychalla, Kelsey Haugen, Arushi Khurana, Paul J. Hampel, Urshila Durani, David Dingli, Suzanne R. Hayman, Prashant Kapoor, Yucai Wang, Moritz Binder, Saad S. Kenderian, Taxiarchis Kourelis, Shaji Kunnathu Kumar, Rahma M Warsame, N. Nora Bennani, Morie A. Gertz, Patrick B Johnston, Stephen M Ansell, Yi Lin
Journal: Blood (2023)
Early Results of the Phase I/II Study Investigating the All-Oral Combination of the Menin Inhibitor Revumenib (SNDX-5613) with Decitabine/Cedazuridine (ASTX727) and Venetoclax in Acute Myeloid Leukemia (SAVE)
Authors: Ghayas C. Issa, Branko Cuglievan, Courtney D. DiNardo, Nicholas J. Short, David McCall, Amber Gibson, Cesar Nunez, Miriam B. Garcia, Michael Roth, Aram Bidikian, Allison Pike, Sheila Tan, Brianna Kammerer, Musa Yilmaz, Tapan M. Kadia, Naveen Pemmaraju, Maro Ohanian, Naval Daver, Elias Jabbour, Gautam Borthakur, Farhad Ravandi, Guillermo Garcia-Manero, Michael Andreeff, Hagop M. Kantarjian
Journal: Blood (2023)
Value of Prophylactic Plasma Treatment and Incidence of Acute Episodes in Patients Enrolled in the International Hereditary Thrombotic Thrombocytopenic Purpura Registry
Authors: Marissa Schraner, Erika Tarasco, Odile Stalder, Kenneth D. Friedman, James N. George, Ingrid Hrachovinova, Paul N. Knöbl, Masanori Matsumoto, Reinhard Schneppenheim, Anne-Sophie Von Krogh, Zuzana Cermakova, Magdalena Górska-Kosicka, Kazuya Sakai, György Sinkovits, Yasmine El Chazli, Carlo R. Largiadèr, Oleg Pikovsky, Jerzy Windyga, Bernhard Lämmle, Johanna A. Kremer Hovinga
Journal: Blood (2023)
Effective Gene Therapy for Hemophilia a: Novel Re-Dosable Non-Viral Formulation That Provides Stable, and Durable FVIII Expression with Improved Tolerability
Authors: Brian Truong, Khal Hajj, Johannes Schwerk, Dongyang Zhang, Johnnatan Tamayo, Gizem Guzelsoy, Joseph Kubicki, Alicia Davis, Lijun Huang, Gopi Vemuri, Kevin Johnson, Dan Smith, Jordan Bendor, Mu Li, Manjunath Goolyam, Daniel Abernathy, Pranav Nyshadham, Fernando Espinoza, Michelle Burrascano, James Yen, Kevin Briseno, Min Tong, Jen Beck, Joseph Lucas, Pavan Battiprolu, Michael Bennett, Blair Madison, Brent Warner, Eric Ostertag, Joshua Rychak
Journal: Blood (2023)
Polytypic B-Cells, B-Cell Lymphoproliferative Disorders/Lymphomas, and Neoplastic T-Cells Divergently Differentiate from <i>TET2</i>-/ <i>DNMT3A</i>-Mutated Clonal Hematopoiesis in Patients with Follicular Helper T-Cell Lymphomas/Lymphoproliferative Disorders
Authors: Natasha Lewis, Kseniya Petrova-Drus, Rohan Sardana, Qi Gao, Shenon Sethi, Wenbin Xiao, Mikhail Roshal, Jeeyeon Baik, Himanshu Bhurtel, Alison Moskowitz, Steven M. Horwitz, Ahmet Dogan
Journal: Blood (2023)
Acute Leukemias of Ambiguous Lineage Have Durable Response to Hypomethylating Agents Plus Venetoclax in Older Patients
Authors: Joshua A Fein, Sanjay Patel, Neela Easwar, Michal Bar-Natan, Amy Chadburn, Pinkal Desai, Julia Geyer, Michael Kluk, Madhu M Ouseph, Ellen K. Ritchie, Michael Samuel, Paul Simonson, Gail J. Roboz, Justin D. Kaner
Journal: Blood (2023)
The Impact of Age and Genomics on Drug Sensitivity in 1,076 Children and Adults with B-Cell Acute Lymphoblastic Leukemia
Authors: Satoshi Yoshimura, Zhenhua Li, Yoshihiro Gocho, Wenjian Yang, Kristine R Crews, Shawn H.R. Lee, Kathryn G. Roberts, Charles G. Mullighan, Mary V. Relling, Federico Antillon-Klussmann, Allen Eng Juh Yeoh, Mignon L. Loh, Mark R. Litzow, Sima Jeha, Seth E. Karol, Hiroto Inaba, Ching-Hon Pui, Marina Y. Konopleva, Nitin Jain, Wendy Stock, Elisabeth Paietta, Elias Jabbour, Steven M. Kornblau, William E. Evans, Jun J. Yang
Journal: Blood (2023)
Unrevealing Hematopoietic Reconstruction Discrepancies after Allo-UCBT and Allo-PBSCT at Single Cell Resolution
Authors: Qing Li, Linjie Wu, Fang Liu, Huimin Sun, Yingying Huo, Shihui Ma, Fang Dong, Xiaofan Zhu, Sha Hao, Tao Cheng
Journal: Blood (2023)
Depletion of the Mitochondrial E3 Ligase MARCH5 Induces Synthetic Lethality to BCL2 Inhibitor (Venetoclax) Therapy in Cell Lines Representative of Diverse Blood Cancers
Authors: Thomas E Lew, Mark Van Delft, Chris Riffkin, Georgiou Angela, Christine White, Yin Yuan, Jahja Michelle, Mary Ann Anderson, Rachel Thijssen, David C.S. Huang, Mark A Dawson, Andrew W. Roberts
Journal: Blood (2023)
Relapse after First-Line Fixed Duration Ibrutinib + Venetoclax: High Response Rates to Ibrutinib Retreatment and Absence of BTK Mutations in Patients with Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) with up to 5 Years of Follow-up in the Phase 2 Captivate Study
Authors: Paolo Ghia, William G. Wierda, Paul M. Barr, Thomas J. Kipps, Tanya Siddiqi, John N. Allan, Zoë Hunter, Cathy Zhou, Anita Szoke, James P. Dean, Constantine S. Tam
Journal: Blood (2023)
Graft-Versus-Host Disease after Anti-CD19 Chimeric Antigen Receptor T-Cell Infusion Post Allogeneic Hematopoietic Cell Transplantation: A Transplant Complications and Paediatric Disease Working Parties EBMT Joint Study
Authors: Guillermo Orti, Christophe Peczynski, Christian Koenecke, William Boreland, Maeve O'Reilly, Martin Bornhäuser, Adriana Balduzzi, Caroline Besley, Krzysztof Kalwak, Samppa Ryhanen, Tayfun Güngör, Robert F. Wynn, Peter Bader, Stephan Mielke, Didier Blaise, Persis Amrolia, Ibrahim Yakoub-Agha, Friso G. J. Calkoen, Maria-Luisa Schubert, Victoria Potter, Wolfgang Holter, Nicolaus Kröger, Mi Kwon, Henrik Sengeloev, Helene Schoemans, Ivan Sergeevich Moiseev, Olaf Penack, Zinaida Peric
Journal: Blood (2023)
Factor B Inhibition with Oral Iptacopan Monotherapy Demonstrates Sustained Long-Term Efficacy and Safety in Anti-C5-Treated Patients (pts) with Paroxysmal Nocturnal Hemoglobinuria (PNH) and Persistent Anemia: Final 48-Week Results from the Multicenter, Phase III APPLY-PNH Trial
Authors: Antonio M Risitano, Austin Kulasekararaj, Alexander Roeth, Phillip Scheinberg, Yasutaka Ueda, Carlos de Castro, Eros Di Bona, Morag Griffin, Saskia MC Langemeijer, Hubert Schrezenmeier, Wilma Barcellini, Vitor AQ Mauad, Jens Panse, Philippe Schafhausen, Suzanne Tavitian, Eloise Beggiato, Anna Gaya, Wei-Han Huang, Toshio Kitawaki, Abdullah Kutlar, Jaroslaw P. Maciejewski, Rosario Notaro, Vinod Pullarkat, Jörg Schubert, Louis Terriou, Michihiro Uchiyama, Flore Sicre De Fontbrune, Camilla Frieri, Ferras Alashkar, Shreyans Gandhi, Rakesh Kumar, Christine Thorburn, Samopriyo Maitra, Susan Solar-Yohay, Tomasz Lawniczek, Marion Dahlke, Régis Peffault De Latour
Journal: Blood (2023)
Favorable Fertility Outcome in a Large Cohort of Sickle Cell Disease Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Mazin Mohamed Abdulsalam, Bader Alahmari, Ahmed S. Alaskar, Ayman Hejazi, Hind Salama, Abdulrahman Al Raizah, Abdullah Alsaleh, Ayman Ibrahim, Mohammed Bakkar, Ayel Yahya, Abdul Rauf Ghori, Zied Aljubour, Rawan Almohammadi, Tahani Alanazi, Rasha Ahmed, Amani Alharbi, Inaam Shehabeddine, Maybelle Ballili, Husam Mazin Alsadi, Mohsen Alzahrani
Journal: Blood (2023)
MAIT Cell Frequencies within PBSC Grafts Are Associated with Donor CMV Serostatus and Age: An Initial Analysis from the DKMS and NMDP Graft Composition Study
Authors: Hugh R. MacMillan, Hans Minderman, Ashley Spahn, Orla Maguire, Elke Rücker-Braun, Bose Falk, Henning Baldauf, Heike Uhlemann, Nicole Heymann, Lisa Heiduschke, Kieran L. O'Loughlin, Alexander H. Schmidt, Steven M. Devine, Jeffery J. Auletta, Falk Heidenreich, Jay Feinberg, Huy Pham, Marcel R.M. van den Brink, Evan W. Newell, Johannes Schetelig, Stephen R. Spellman, Kate A. Markey
Journal: Blood (2023)
Intradermal Vaccination with Vididencel in MRD+ AML-Patients Leads to Increase in Antigen Presenting Cells and T-Cells to the Injection Site, Visualized Using Imaging Mass Cytometry, Showing Local Immune Cell Interactions Leading to Systemic Immune Responses
Authors: Oystein Sefland, Reidun Kristin Kopperud, Hester Van Zeeburg, Jeroen Rovers, Maria Omsland, Arjan A. Van de Loosdrecht, Bjorn T. Gjertsen
Journal: Blood (2023)
Sex-Related Differences in Fetal Hemoglobin Levels in Sickle Cell Patients
Authors: Neha Balachandran, Satya Jella, Heath Aston, Faizan Boghani, Casey Gazza, Emma Hazenberg, Daniel Herrera, Elena Wernecke, Ahmed Shetewi, Siera Gollan, Asim Ahmed, Hongyan Xu, Girindra Raval, Abdullah Kutlar
Journal: Blood (2023)