PB2355: EFFECTS OF CHRONIC DISEASE LOCUS INTERVENTION MODEL ON QUALITY OF LIFE AND STRESS IN PATIENTS WITH HEMATOPOIETIC STEM CELL TRANSPLANTATION
Authors: A. Sun, J. Tao, F. Wu, L. Gao, C. Zhang
Journal: HemaSphere (2022)

Background: With the continuous improvement of hematopoietic stem cell transplantation technology, donor source system and supportive treatment, the long-term survival rate of patients after hematopoietic stem cell transplantation has been continuously improved, but it is often accompanied by chronic or late complications, including severe chronic graft-versus-host disease (GVHD), osteoporosis, organotoxicity, infertility, etc, It has an adverse impact on the quality of life of patients. According to the stage change of chronic disease trajectory, the chronic disease trajectory model provides continuous and scientific nursing intervention for patients around their disease-related behavior, self-concept behavior and daily life behavior, aiming to improve patients’ self-management ability, control disease symptoms, prevent complications and improve patients’ quality of life. Aims: To investigate the influence of chronic disease trajectory intervention mode on quality of life and stress in patients with hematopoietic stem cell transplantation. Methods: A total of 100 hematopoietic stem cell transplantation patients who received hematopoietic stem cell transplantation from October 2019 to December 2020 in a grade III, Grade A hospital in Chongqing were selected as the investigation subjects. Patients admitted on Mondays and Thursdays were selected as the experimental group, and patients admitted on other times were selected as the control group, with 50 patients in each group. The control group was treated with routine nursing, and the experimental group was treated with chronic disease track intervention mode nursing based on routine nursing. The anxiety Self-rating Scale (SDS), self-rating Depression Scale (SAS), quality of life and pressure score of the two groups were compared before transplantation, during bone marrow suppression period, when patients were discharged from the warehouse and 1 month after transplantation. Results: Before storage, there were no significant differences in the scores of quality of life, depression, anxiety and pressure between the two groups (P>0.05), and the scores of depression, anxiety and pressure in the experimental group were significantly lower than those in the control group in the marrow suppression period, out of storage and 1 month after transplantation (P<0.05). The score of quality of life in experimental group was significantly lower than that in control group at bone marrow suppression stage and 1 month after transplantation (P<0.05). The scores of quality of life in the control group were significantly higher in the marrow suppression period, at the time of warehousing and 1 month after transplantation (P<0.01). There were no significant differences in depression and anxiety scores among the experimental groups at different periods (P>0.05), and the pressure score at 1 month after transplantation was significantly lower than that before storage (P<0.01). The depression, anxiety and stress scores of the control group were significantly higher than those of the control group at the bone marrow suppression stage, the time of discharging and 1 month after transplantation (P<0.01) Summary/Conclusion: The chronic disease trajectory model can provide early warning according to the disease trajectory from the beginning of HSCT intervention to the continuous attention 1 month after HSCT, which is helpful to relieve the pressure of HSCT patients.