tbuckley/cabot-search huggingface dataset:
AB1662 IMPACT OF COMORBIDITIES AND FREQUENCY OF ADMISSIONS ON MORTALITY IN PATIENTS WITH SYSTEMIC AUTOIMMUNE RHEUMATIC DISEASES
Authors: H. Amar Muñoz, I. Catrejón, A. Ramos, F. Montero, K. Carpio, J. Molina Collada, B. Serrano-Benavente, J. M. Alvaro-Gracia, J. Martínez-Barrio
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Data on mortality in patients with systemic autoimmune rheumatic diseases (SARDs) is limited. Most evidence is restricted to patients with systemic lupus erythematosus and ANCA vasculitis [1-2]. In recent years, mortality has been more closely associated with cardiovascular pathologies and infections and less with disease activity. <h3>Objectives</h3> To assess the impact of comorbidities and hospital admissions on mortality in patients with SARDs in a tertiary referral hospital. <h3>Methods</h3> We conducted a retrospective observational study including adult patients with SARDs (Table 1) followed up in our Multidisciplinary Unit of Systemic Autoimmune Diseases between January 2017 and December 2019. In this cohort, patients were under similar follow-up and treatment protocols. Gathered data includes epidemiological, hospitalization (number of admissions, hospital stay and reasons for admission) and exitus information. In hospitalized patients, associated comorbidities were also reviewed. A comparison was made between patients who required at least one admission during the study period and those who did not, in addition to a description of mortality. Kaplan Meier curves are presented by number of comorbidities and number of admissions. <h3>Results</h3> Of the 1749 patients with SARDs included in our cohort, 432 (24.7%) required hospitalization during the study period. Of those hospitalized, mean age was 64 years and 315 (73%) were women. A total of 61 (14%) deaths occurred among patients admitted to the hospital vs 77 (5.9%) among non-hospitalized, within the study period. Behcet's disease and IgG4-related disease presented highest mortality rate (29%) in our cohort of hospitalized patients, closely followed by antiphospholipid syndrome (23%) and Sjögren's syndrome (20%) (Table 1). No statistically significant differences were observed in mortality according to the number of admissions (p=0.56) or comorbidities (p=0.41), although in the latter, an increasing trend was observed as the number of comorbidities increased (survival according to the number of comorbidities: no comorbidities =14 years, one comorbidity =8.9 years, two or more comorbidities =6.4 years) (Graph 1). <h3>Conclusion</h3> We have found no impact of comorbidities or hospital admissions in mortality in patients with SARDs. Among hospitalized patients, higher mortalities were observed in Behcet's disease, IgG4-related disease, antiphospholipid syndrome and Sjögren's syndrome. In addition, a trend towards greater mortality was observed in relation to the number of comorbidities. <h3>References</h3> [1]Manadan AM, et al. ACR Open Rheumatol. 2020 Nov;2(11):683-689. [2]Rivera, Mavi et al. Clinical rheumatology vol. 41,1 (2022): 159-166. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1688 FINDING THE NEEDLE IN THE HAYSTACK: SEROLOGICAL AND URINARY BIOMARKERS IN BEHÇET’S DISEASE; A SYSTEMATIC REVIEW
Authors: M. Arbrile, M. Radin, D. Medica, P. Miraglia, M. L. A. Rilat, I. Cecchi, S. G. Foddai, A. Barinotti, E. Menegatti, D. Roccatello, S. Sciascia
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Urinary and serological markers play an essential role in the diagnostic process of autoimmune diseases. However, to date, specific and reliable biomarkers for diagnosing Behçet's disease (BD) are still lacking, negatively affecting the management of these patients [1] <h3>Objectives</h3> We aimed to systematically review the currently available literature on the identification and characterization of serological and urinary BD biomarkers investigated in the last 25 years. <h3>Methods</h3> We performed a systematic literature review using the PICO (Population, Intervention, Comparison, and Outcomes) strategy on serological and urinary BD biomarkers investigated in the last 25 years. <h3>Results</h3> One hundred-eleven studies met the eligibility criteria (6301 BD patients, 5163 controls). Most of them were retrospective, while 5 (5%) were prospective. One hundred-ten studies (99%) investigated serological biomarkers, and only 2 (2%) focused on urinary biomarkers. One hundred-three studies (93%) explored the diagnostic potential of the biomolecules, whereas 62 (56%) tested their effect on disease activity monitoring. Most articles reported an increase in inflammatory markers and in pro-oxidant molecules, with a decrease in antioxidants. Several miRNAs (including miR-93, miR-106b, miR-25, miR-146a, miR-326, and miR-181b) were assessed by three studies (3%) included in this systematic review, with contrasting conclusions. Promising results have been shown by the –omics sciences, offering a more holistic approach. Interestingly, the distribution of the country of origin of each study showed the characteristic spread of BD along the ancient Silk Road. <h3>Conclusion</h3> Despite the vast number of investigated markers, existing evidence indicates a persistent gap in BD diagnostic/prognostic indices. While new steps have been taken in the direction of pathogenesis and disease monitoring, international efforts for a diagnostic marker are still further needed. <h3>Reference</h3> [1]Leccese P, Alpsoy E. Behçet's Disease: An Overview of Etiopathogenesis. Front Immunol. 2019 May 10;10:1067. doi: 10.3389/fimmu.2019.01067. PMID: 31134098; PMCID: PMC6523006 <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1760-HPR THE RELATIONSHIP BETWEEN DISEASE ACTIVITY LEVEL AND WRIST JOINT POSITION SENSE, GRIP STRENGTH AND DYNAMIC GRIP ENDURANCE IN PSORIATIC ARTHRITIS
Authors: M. Köprülüoğlu, İ. Naz, D. Solmaz, S. Akar
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Dynamic grip endurance in psoriatic arthritis is one of the affected functional parameters during the disease process. However, there are limited studies about dynamic grip endurance related factors. <h3>Objectives</h3> To investigate the relationship between disease activity level and joint position sense and dynamic grip endurance in psoriatic arthritis. <h3>Methods</h3> A total of 27 PsA patients (age:53.33 ±11.85 years, women/men:16/5) who were classified by the Classification Criteria for Psoriatic Arthritis (CASPAR) criteria and followed in outpatient clinic were included in our study. The socio-demographic characteristic of all patients recorded. Disease activity level was assessed with the DAPSA score. Wrist joint position sense was evaluated by a goniometric re-position error test. Grip strength and endurance were examined by a hand dynamometer (Lafayette Professional Hand Dynamometer, USA). Data analysis was performed with Spearman Correlation Coefficient. <h3>Results</h3> Patients' diagnosis year, tender joint on hand, and swollen joint on hand were 4.50 years, 23, and 18, respectively. DAPSA scores were 28.67 ±14.85 and moderate-high level. There was no relationship between DAPSA scores and joint position error and dynamic grip endurance on both sides (p&gt;0.05). A moderate level correlation was found between the DAPSA score and grip strength on both sides (p&lt;0.05, r=-0.516 and -0.570 dominant and non-dominant side, respectively). <h3>Conclusion</h3> Our study showed that PsA patients had lower grip strength during the exacerbation period. Since joint position sense and grip endurance were low independents of disease activity, they may not are associated with disease activity in this study. We think that in cases where disease activity increases, approaches that protect grip strength can be added to the disease management process. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1661 INCREASED RISK OF TOTAL HIP ARTHROPLASTY IN RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS OVERLAP SYNDROME
Authors: C. C. Lai, Y. S. Chang, C. F. Su, L. Sheng-Hong
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) have increased risk of total hip arthroplasty (THA).<sup>[1,2]</sup> Patients with RA and SLE overlap syndrome (RA+SLE) may have a more common articular involvement than each disease does. However, the risk of THA in RA+SLE patients is not fully investigated. <h3>Objectives</h3> To identify the risk and outcome of THA in RA+SLE patients in a longitudinal cohort. <h3>Methods</h3> We analyzed datasets derived from Taiwan National Health Insurance Research Database from 2000 to 2018. Patients with RA, SLE, and RA+SLE were selected and matched according to the age and gender. Risk and outcome of THA was compared, and multivariable Cox proportional hazards models were used to analyze the risk factors. <h3>Results</h3> 2270 RA+SLE patients were matched with 9080 RA and 9080 SLE patients. RA+SLE patients had the highest rate of THA than RA or SLE patients did (2.16% vs 1.22% or 1.76%, respectively; p=0.0008). Avascular necrosis (1.45%) followed by osteoarthritis (1.28%) were the most common reasons for THA in RA+SLE patients. The rate of THA revision was the highest in RA patients than in RA+SLE or SLE patients (9.91% vs. 4.08% or 6.25%, respectively; p&lt;0.0001). Chronic kidney disease (HR: 4.94, 95% CI: 2.51–9.71, p&lt;0.0001), use of prednisolone or equivalence &gt;10 mg/day (HR: 2.1, 95% CI: 1.53–2.88, p&lt;0.0001), azathioprine (HR: 2.15, 95% CI: 1.68–2.74, p&lt;0.0001), and biologic agents (HR: 2.03, 95% CI: 1.46–2.81, p&lt;0.0001) increases the risk of THA independently. <h3>Conclusion</h3> RA+SLE patients had the highest rate of THA than patients with individual disease alone, however, the rate of THA revision was the highest in RA patients than in the other groups. Comorbidities, treatment with a higher daily dose of steroid, and immunosuppressants may contribute to the risk of THA. <h3>References</h3> [1]Chen CH, Hsu CW, Lu MC. Risk of joint replacement surgery in Taiwanese female adults with systemic lupus erythematosus: a population-based cohort study. BMC Musculoskelet Disord. 2019;20:314. [2]Taylor-Williams O, Inderjeeth CA, Almutairi KB, et al. Total Hip Replacement in Patients with Rheumatoid Arthritis: Trends in Incidence and Complication Rates Over 35 Years. Rheumatol Ther. 2022;9:565-580. <h3>Acknowledgements</h3> The authors appreciate Yi-Chun Lin for his technical support in data sampling and statistical analysis. <h3>Disclosure of Interests</h3> None Declared.
AB1772-HPR PNEUMOCOCCAL VACCINATION IN CHRONIC INFLAMMATORY DISEASE(CIRD) PATIENTS: REASONS FOR NON-PRESCRIPTION AND SOLUTIONS
Authors: S. Ez-Zaoui, H. Rkain, F. Kronbi, T. Latifa, S. Bahloul, I. Bensaghir, S. Farih, F. El Joumani, R. Honsali, N. Hajjaj-Hassouni, F. Allali
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background:</h3> <h3>Objectives</h3> To explore rheumatologists' reasons for non prescription of pneumococcal vaccination in CIRD patients and to collect solutions proposed by rheumatologists. <h3>Methods</h3> This is a cross-sectional study carried out by the vaccination working group of the Moroccan Society of Rheumatology. The survey collected data on reasons of pneumococcal vaccination abstinence in rheumatology practice, and solutions proposed to improve pneumococcal vaccination in CIRD patients. <h3>Results</h3> This survey included 125 rheumatologists (mean age 42.4 +/-12.1 years). The sector of practice was respectively 31.2 %,34.4 %,34.4 % for the public sector, private sector and University Hospital. 36.9% of rheumatologists have never prescribed pneumococcal vaccination for their CIRD patients. Table 1 illustrate reasons given by rheumatologists for non vaccination of their CIRD patients against pneumococcal infection. <h3>Conclusion</h3> The main obstacles to the pneumococcal vaccination prescription by rheumatologists are related to the lack of knowledge of vaccination protocol and the forgetfulness. Therefore, the Optimization of pneumococcal vaccination would necessarily focus on combating the obstacles to this preventive practice in CIRD patients. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1796-HPR ALTERED ANKLE AND KNEE MUSCLE ARCHITECTURE AND FOOT PRESSURE DISTRIBUTION IN KNEE OSTEOARTHRITIS PATIENTS: A COMPARATIVE CROSS SECTIONAL STUDY
Authors: N. Cigercioglu, H. Apaydin, G. Baltaci, H. Guney Deniz
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Osteoarthritis (OA) of the knee is a common degenerative and chronic disease as well as a major cause of knee pain and functional disability. Alterations in lower extremity biomechanics may lead adaptive changes in walking, foot pressure distribution, lower extremity muscle strength as well as the architectural characteristics of the knee and ankle muscles in patients with knee OA. <h3>Objectives</h3> The aim of this study was to compare the knee and ankle muscle architecture and foot pressure distribution differences in knee OA patients with healthy individuals. <h3>Methods</h3> Twenty patients with knee OA (mean age= 53.35±1.21 years, mean BMI=31.69±0.93 kg/m2) and twenty healthy controls (mean age= 51.05±0.63 years, mean BMI=29.28±1.15 kg/m2) were included in the study. Rectus Femoris (RF), Vastus Medialis (VM), Peronalis Longus (PL) and Medial Gastrocnemius (MG) muscles thickness, pennation angle and fat thickness were evaluated using B-Mode ultrasonography (Esaote MyLab X8 eXP Ultrasound System, Florence, Italy). Ultrasound images were analyzed offline using an image analysis software (Image J, National Institutes of Health, Bethesda, MD, USA) program. Plantar pressure distribution was evaluated using the Digital Biometry Scanning System and Milletrix software (DIASU, Italy). Mann-Whitney U test was used to compare knee OA patients with the healthy individuals. <h3>Results</h3> The age (p=0.189) and BMI (p=0.367) were comparable between groups. The muscle architectural characteristics of RF, VM, PL and MG were different between groups (Table1). The distribution of foot pressure parameters were altered in knee OA patients compared to healthy controls (Table1). <h3>Conclusion</h3> The fat thickness of ankle and knee muscles were higher in knee OA patients compared to healthy controls. Clinicians should consider adding aerobic and resistance exercises to their treatment programs that will increase muscle thickness and decrease fat thickness. The medial load of the foot increased while the lateral load decrease in these patients. Medial supported insoles may be recommended to reduce the medial load on the foot. <h3>References</h3> [1] Aily JB, de Noronha M, de Almeida AC, et al. Evaluation of vastus lateralis architecture and strength of knee extensors in middle-aged and older individuals with knee osteoarthritis. Clin Rheumatol. 2019;38(9):2603-2611. [2] Karapinar M, Ayyildiz VA, Unal M, Firat T. Effect of intramuscular fat in the thigh muscles on muscle architecture and physical performance in the middle-aged women with knee osteoarthritis. J Orthop Sci. 2022; S0949-2658(22)00324-4 <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1800-HPR EVALUATION OF KNOWLEDGE AND PRACTICES OF PATIENTS WITH SPONDYLOARTHRITIS
Authors: S. Farih, T. Latifa, R. Honsali, H. Rkain, I. Bensaghir, C. Charoui, B. Amine, R. Bahiri, S. Elhilali, R. Razine, C. Nouri, F. Kronbi, S. Ez-Zaoui, F. El Joumani, S. Bahloul, N. Alami, F. Allali
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Spondyloarthritis is a chronic inflammatory rheumatic disease mostly affecting young adults, causing functional disability and impaired quality of life. Thus, patient education is a major component to improve their knowledge of the disease, therapeutic compliance and quality of life. <h3>Objectives</h3> The aim of this study is to evaluate the knowledge and practices of patients with spondyloarthritis and determine the factors associated with them. <h3>Methods</h3> This is an observational, descriptive, analytical and monocentric study, in patients followed up at Al Ayachi University Hospital in the Rabat-Sale region of Morocco. The study duration was from the beginning of May 2022 to the beginning of July 2022. The consent of the study population was free and informed. The participants were interviewed and voluntarily responded to a questionnaire drawn up by a team of rheumatologists, which includs socio-demographic information, prior knowledge and practices of patients with spondyloarthritis.We calculated a score of correct answers ranging between 0 and 10 for each patient. <h3>Results</h3> We recruited 100 patients with a mean age of 39.3 years ± 12.9, 59% were men and 17% were illiterate. 85% of the population came from an urban environment, and 79% were unemployed. 68% of the patients suffered from ankylosing spondylitis, 17% had psoriatic arthritis, 13% were affected by inflammatory bowel disease associated arthropathy and 2% had juvenile spondylarthritis. 31% of patients considered that the disease can affect young adults, wherein 43% reported a male predominance. 47% reported that the cause of the disease is genetic, 34% declared that it is related to immunity whereas entheses affection was known by 52% of patients. 81% find that therapeutic management helps prevent deformities and 97% see that it improves the quality of life. Furthermore, only 4% of patients knew that NSAIDs are a disease-modifying treatment and 7% were aware that pneumopathy could be a potential complication of Methotrexate. 73% of patients knew what a biologic drugs is, when biosimilar was only known by 10% of them, yet 45% knew that tuberculosis is one of the infections that can occur under biologic drugs. This study revealed that 63% of patients had a total score of correct answers superior to 5 (for a max score of 10) and 37% had a total score between 0-5. <h3>Conclusion</h3> Althought this study showed decent knowledge and good practices among the Moroccan patients with spondyloarthritis. The doctor-patient contact and the multimedia information as well as patients' associations remain as useful means to improve this knowledge. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1712 THE BELIEFS OF MOROCCAN PATIENTS WITH CHRONIC INFLAMMATORY RHEUMATIC DISEASES REGARDING MEDICATION AND THEIR IMPACT ON THERAPEUTIC ADHERENCE
Authors: N. El Mansouri, F. Z. Taik, R. Bensaid, F. Z. Aharrane, N. Soba, M. Fourtassi, F. E. Abourazzak
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Adherence is one of the key elements of management in patients with chronic inflammatory rheumatic diseases, and it is likely to be influenced by beliefs about medications, which will influence the management and quality of life of patients. <h3>Objectives</h3> Objective is to assess chronic inflammatory rheumatic diseases patient's beliefs about medications, the factors associated with them, and their impact on therapeutic adherence. <h3>Methods</h3> This was a cross-sectional study that included any patient followed for chronic inflammatory rheumatic diseases. Sociodemographic data, comorbidities, information on inflammatory rheumatism ds (type, pain and activity assessment and and treatments) were collected. Beliefs about medication were assessed by the validated Moroccan version of the Belief on Medicine Questionnaire (BMQ). Catastrophizing, trust in physician and adherence to therapy were assessed by the validated Arabic versions of the pain catastrophizing scale (PCS), trust in physician scale (TPS) and Compliance Questionnaire Rheumatolgy (CQR) <h3>Results</h3> 189 patients were included. The average age was 47.49 ±13.7, 75.7% of the patients were women, 52.4% had comorbidities, 49.2% were illiterate, 56.6% were followed for rheumatoid arthritis, 35.4% for spondyloarthritis and 7.9% for undifferentiated chronic inflammatory rheumatic. The median duration of evolution of chronic inflammatory rheumatic diseases was 8 [3-16.75]. 41.3% of patients were on synthetic DMARDs and 4.2% on biotherapy. The mean VAS pan was 4.77 ± 2.76. 37.6% of patients were in remission. The average CQR was 55.16±8.14 The mean BMQ specific necessity was 20.75±4.77. 67.4% of the patients strongly believed that medication is essential to maintain their health. The mean of the specific BMQ concerns was 14.47±5.8. The main concerns of the patients were the fear of being dependent on the medication they were taking (36.2%) and the potentially harmful consequences of their treatment in the long term (35.5%). The median necessity-concern differential was 6[1-12] suggesting a positive benefit-risk ratio perceived by the patients. In multivariate analysis (Table1), there was a statistically significant association between education level, catastrophizing, trust in the physician. and the necessity-concern differential. There was also a signification correlation between the therapeutic compliance score and the BMQ necessity score and the BMQ differential necessity-concerns. <h3>Conclusion</h3> Moroccan patients followed for chronic inflammatory rheumatic diseases have a rather positive perception of their medication. This perception seems to influence their adherence to treatment. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.