Endocrinology and Metabolism: An Annotated Bibliography of Recent Literature
Journal: Annals of Internal Medicine (1979)

The Literature of Medicine1 April 1979Endocrinology and Metabolism: An Annotated Bibliography of Recent LiteratureReferences to Journal Articles and Other PapersENDOCRINOLOGY AND METABOLISM COMMITTEEENDOCRINOLOGY AND METABOLISM COMMITTEESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-4-726 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis bibliography includes references to 99 recently published journal papers and similar sources that represent important developments in the concept and practice of internal medicine. It has been compiled by the Endocrinology and Metabolism Committee as part of the Medical Knowledge Self-Assessment Program V Syllabus.In preparing this bibliography, the committee reviewed MEDLINE†bibliographic printouts of journal articles published since the beginning of 1975 and also drew on sources in libraries of hospitals and other clinical institutions in the United States and Canada; thus, only papers in English are listed, and most are from American journals....Pituitary Gland NEUROHYPOPHYSIS Adrenal Gland Thyroid Gland Diabetes Mellitus Hyperlipidemia Obesity and Malnutrition Parathyroid and Bone Male Reproduction1. FRANTZ A: Prolactin. N Engl J Med 298:201-207, 1978 Review of current knowledge of prolactin action and physiology and disorders of prolactin secretion, with particular emphasis on prolactin-secreting pituitary tumors and the significance of amenorrhea as a manifestation of hyperprolactinemia. Google Scholar2. GUILLEMINGERICH RJ: Somatostatin: physiological and clinical significance. Annu Rev Med 27:379-388, 1976 A review describing the many actions of somatostatin, a hormone that inhibits the secretion of several pituitary and many other hormones. CrossrefMedlineGoogle Scholar3. JORDANKENDALLKERBER RJC: The primary empty sella syndrome. Analysis of the clinical characteristics, radiographic features, pituitary function and cerebrospinal fluid adenohypophysial hormone concentrations. Am J Med 62:569-580, 1977 Describes the clinical, hormonal, and radiologic findings in 12 patients with the empty sella syndrome, which can and should be recognized by noninvasive methods. The diagnosis is confirmed if visual and hormonal examinations remain normal on periodic re-evaluation. CrossrefMedlineGoogle Scholar4. KLEINBERGNOELFRANTZ DGA: Galactorrhea: a study of 235 cases, including 48 with pituitary tumors. N Engl J Med 296:589-600, 1977 Galactorrhea was most commonly idiopathic (with menses), due to a pituitary tumor, idiopathic with amenorrhea, or due to drugs. Hyperprolactinemia was variably present, most often in patients with amenorrhea. Thirteen patients were men. CrossrefMedlineGoogle Scholar5. NALDICHPINTOKUSHNERLINKRICHEFFLEEDSCHASE TRMJINN: Evaluation of sellar and parasellar masses by computed tomography. Radiology 120:91-99, 1976 Computed tomography was shown to be a reliable technique for detecting suprasellar masses, the direction and degree of parasellar extension of pituitary tumors, and cystic changes or calcification in the tumors. CrossrefMedlineGoogle Scholar6. RUDMANFLEISCHERKUTNERRAGGIO DAMJ: Suprahypophyseal hypogonadism and hypothyroidism during prolonged coma after head trauma. J Clin Endocrinol Metab 45:747-754, 1977 Patients remaining comatose 2 or more weeks after head trauma developed hypothyroidism with low serum levels of thyroid-stimulating hormone and hypogonadism with low serum levels of luteinizing hormone and follicle-stimulating hormone. Responses to thyrotropin-releasing hormone and gonadotropin-releasing hormone were normal. Hormonal improvement accompanied neurologic recovery. CrossrefMedlineGoogle Scholar7. SAMAANBAKDASHCADERAOCANGIRJESSEBALLANTYNE NMJARA: Hypopituitarism after external irradiation. Evidence for both hypothalamic and pituitary origin. Ann Intern Med 83:771-777, 1975 Fourteen of 15 patients who had received radiation therapy for nasopharyngeal carcinoma had evidence of endocrine deficiency 5 to 20 years later. In most the locus of the abnormalities was hypothalamic, but some had evidence of primary pituitary deficiency. LinkGoogle Scholar8. WEISBERG L: Asymptomatic enlargement of the sella turcica. Arch Neurol 32:483-485, 1975 Patients with enlarged sella turcica without visual field deficits or hormonal hypersecretion were followed without therapy except for hormonal replacement as needed. Most with hypopituitarism initially developed visual loss in 1 to 5 years; those asymptomatic or having only headache did not. CrossrefMedlineGoogle Scholar9. WILSONDEMPSEY CL: Transsphenoidal microsurgical removal of 250 pituitary adenomas. J Neurosurg 48:13-22, 1978 This series includes patients with all types of pituitary tumors. Although follow-up was short and detailed endocrinologic evaluation lacking, the procedure was effective and complications few. CrossrefMedlineGoogle Scholar10. COBBSPAREREICHLIN WSS: Neurogenic diabetes insipidus: management with dDAVP (1-desamino-8-D arginine vasopressin). Ann Intern Med 88:183-188, 1978 1-Desamino-8-D arginine, a new vasopressin analogue with a long duration of action after intranasal administration, provided excellent control of polyuria and polydipsia, with few side-effects, in 29 patients with diabetes insipidus. LinkGoogle Scholar11. AXELROD L: Glucocorticoid therapy. Medicine (Baltimore) 55:39-65, 1976 An in-depth review of indications for steroid therapy, their mechanism of action, and the relative potency of various preparations. Glucocorticoid side-effects and the problem of glucocorticoid withdrawal are also discussed. CrossrefMedlineGoogle Scholar12. CAREYVAUGHANPEACHAYERS REMC: Activity of (des-aspartyl) angiotensin II and angiotensin II in man. Differences in blood pressure and adrenocorticoid responses during normal and low sodium intake. J Clin Invest 61:20-31, 1978 This study compares the relative potency of angiotensin II and angiotensin III, which some investigators believe is a more potent angiotensin. The clinical implications of these findings are clearly discussed. CrossrefMedlineGoogle Scholar13. CASEWALLACEKEIMWEBERSEALYLARAGH DJHMJJ: Possible role of renin in hypertension as suggested by renin-sodium profiling and inhibition of converting enzyme. N Engl J Med 296:641-646, 1977 A converting enzyme inhibitor was used to block renin activity in 65 patients with hypertension. The usefulness and potential pitfalls of this agent in the diagnosis of renal vascular disease are discussed. CrossrefMedlineGoogle Scholar14. DUNNHOOD MV: Prostaglandins and the kidney. Am J Physiol 233:F169-F184, 1977 Review of the biosynthesis, mechanism of action, and secretion of renal prostaglandins. MedlineGoogle Scholar15. GILLFRÖLICHBOWDENTAYLORKEISERSEYBERTHOATESBARTTER JJRAHHJF: Bartter's syndrome: a disorder characterized by high urinary prostaglandins and a dependency of hyperreninemia on prostaglandin synthesis. Am J Med 61:43-51, 1976 Review of the pathogenesis of Bartter's syndrome, with particular reference to the role of prostaglandins. CrossrefMedlineGoogle Scholar16. GITTESMAHONEY RE: Pheochromocytoma. Urol Clin North Am 4:239-252, 1977 General review of the diagnosis, treatment, and prognosis of patients with pheochromocytoma. CrossrefMedlineGoogle Scholar17. GWINUPJOHNSON GB: Clinical testing of the hypothalamalamic-pituitary-adrenocortical system in states of hypoand hypercortisolism. Metabolism 24:777-791, 1975 In-depth review of the most useful clinical tests for diagnosing adrenal cortical disease. CrossrefMedlineGoogle Scholar18. KLEINARNAUDGALLAGHERDELUCARIGGS RSJHB: Intestinal calcium absorption in exogenous hypercortisonism. Role of 25-hydroxyvitamin D and corticosteroid dose. J Clin Invest 60:253-259, 1977 Study of the mechanism underlying the corticosteroid-induced decrease in gastrointestinal calcium absorption, with data indicating that glucocorticoids inhibit activation of vitamin D. CrossrefMedlineGoogle Scholar19. MAXWELLMARKSLUPUCAHILLFRANKLINKAUFMAN MLAPSJ: Predictive value of renin determinations in renal artery stenosis. JAMA 238:2617-2620, 1977 Review of the usefulness of bilateral renal vein renin measurements in 66 hypertensive patients who underwent corrective surgery. CrossrefMedlineGoogle Scholar20. MITCHELLTAYLORPOOLLAKEROLLINSBARTTER JAJCDF: Renin-aldosterone profiling in hypertension. Ann Intern Med 87:596-612, 1977 The value of renin-aldosterone profiling in the evaluation of patients with hypertension remains controversial. This paper reviews one group's experience in classifying 243 such patients. LinkGoogle Scholar21. MOOREDLUHYWILLIAMSCAIN TRGJ: Nelson's syndrome: frequency, prognosis, and effect of prior pituitary radiation. Ann Intern Med 85:731-734, 1976 Review of the frequency and development of Nelson's syndrome in 120 patients treated with adrenalectomy for bilateral adrenal hyperplasia. LinkGoogle Scholar22. SCOTTLIDDLEMULHERINMCKENNASTROUPRHAMY HGJTSR: Surgical experience with Cushing's disease. Ann Surg 185:524-534, 1977 The experience of one institution in the treatment of 119 patients with pituitary-dependent hypercortisolism. CrossrefMedlineGoogle Scholar23. WILLIAMSBRALEYUNDERWOOD GLR: The regulation of plasma 18-hydroxy 11-deoxycorticosterone in man. J Clin Invest 58:221-229, 1976 An assessment of the contribution of this steroid to the development of hypertension in man and a general review of the mechanisms controlling its secretion. CrossrefMedlineGoogle Scholar24. WILSONWILSONSLATONFOSTERLIDDLEHOLLIFIELD HJPJGJ: Saralasin infusion in the recognition of renovascular hypertension. Ann Intern Med 87:36-42, 1977 Saralasin, an angiotensin II antagonist, was infused into 49 patients with renal artery stenosis to assess its predictive value in identifying persons who would benefit from surgery. The article includes a review of its use in screening for renal vascular hypertension and assessment of its predictive value in the patients studied. LinkGoogle Scholar25. AMINOMIYAIKUROTANIZAWAAZUKIZAWATAKAITANAKANISHIKAWASHIMAKUMAHARA NKROMSFKMY: Transient postpartum hypothyroidism: fourteen cases with autoimmune thyroiditis. Ann Intern Med 87:155159, 1977 Goiter and hypothyroidism, probably due to chronic autoimmune thyroiditis, developed in the postpartum period. Spontaneous recovery occurred 5 to 10 months postpartum. Several patients had recurrences subsequent to a second pregnancy. Will these patients develop permanent hypothyroidism later? LinkGoogle Scholar26. BERNALREFETOFF JS: The action of thyroid hormone. Clin Endocrinol 6.227-249, 1977 A lucid description of the multiple effects of thyroid hormone, both as a stimulator of growth and development and as a regulator of tissue metabolism. CrossrefMedlineGoogle Scholar27. BIGOSRIDGWAYKOURIDESMALOOF SEIF: Spectrum of pituitary alterations with mild and severe thyroid impairment. J Clin Endocrinol Metab 46:317-325, 1978 This study demonstrates again the sensitivity of thyroidstimulating hormone secretion to slight decreases in thyroid hormone secretion. Serum triiodothyronine levels were often normal in patients with mild hypothyroidism. Hyperprolactinemia, decreased growth hormone and ACTH secretion after hypoglycemia, and enlargement of the sella turcica were found only with biochemically severe hypothyroidism. CrossrefMedlineGoogle Scholar28. BROWNSOLOMONBEALLTERASAKICHOPRAVAN HERLEWU JDGPIAS: Autoimmune thyroid diseases—Graves' and Hashimoto's. Ann Intern Med 88:379-391, 1978 This UCLA conference report includes sections on hyperthyroidism due to Graves' disease, the immunology of Hashimoto's disease, the significance and utility of serum thyroglobulin measurements, and new forms of therapy for hyperthyroidism. LinkGoogle Scholar29. BURROW G: Hyperthyroidism during pregnancy. N Engl J Med 298:150-153, 1978 Brief but comprehensive review of the changes in thyroid economy that occur during normal pregnancy and the therapy of hyperthyroidism during pregnancy. Includes discussion of fetal and postnatal effects of maternal antithyroid therapy. CrossrefMedlineGoogle Scholar30. DORFMANCOOPERMANNELSONDEPUYPEAKEYOUNG SMRHRR: Painless thyroiditis and transient hyperthyroidism without goiter. Ann Intern Med 86:24-28, 1977 Eight patients with this newly recognized variant of thyroiditis were carefully studied throughout their illness. Although the syndrome appears clinically most like a variant form of subacute thyroiditis, thyroid histology was more characteristic of chronic autoimmune thyroiditis. LinkGoogle Scholar31. GERSHENGORNMCCLUNGCHUHANSONWEINTRAUBROBBINS MMETBJ: Fine-needle aspiration cytology in the preoperative diagnosis of thyroid nodules. Ann Intern Med 87:265-269, 1977 LinkGoogle Scholar32. WALFISHHAZANISTRAWBRIDGEMISKINROSEN PEHMI: Combined ultrasound and needle aspiration cytology in the management of hypofunctioning thyroid nodule. Ann Intern Med 87:270-274, 1977 These two papers describe results of cytologic examination of needle aspiration specimens from solid and cystic thyroid nodules. The procedure was clearly safe and provided accurate information in about 90% of patients. LinkGoogle Scholar33. GREERKAMMERBOUMA MHD: Short-term antithyroid drug therapy for the thyrotoxicosis of Graves' disease. N Engl J Med 297:173-176, 1977 Patients with hyperthyroidism due to Graves' disease were treated with antithyroid drugs until clinically euthyroid, and then treatment was discontinued. This required 3 to 5 months, and 40% of the patients remained euthyroid; a remission rate similar to that which follows such therapy for 1 to 2 years. CrossrefMedlineGoogle Scholar34. KAPLANUTIGER MR: Diagnosis of hyperthyroidism. Clin Endocrinol Metab 7:97-113, 1978 The abnormalities in thyroid hormone production that occur with hyperthyroidism, and the utility and interpretation of currently available diagnostic procedures. Hyperthyroidism usually can be diagnosed using a few simple tests, and extensive investigation is rarely needed. CrossrefMedlineGoogle Scholar35. MAZZAFERRIYOUNGOERTELKEMMERERPAGE ERJWC: Papillary thyroid carcinoma: the impact of therapy in 576 patients. Medicine (Baltimore) 56:171-196, 1977 Thorough study of this most common type of thyroid carcinoma. Evidence indicates that patients who had near total thyroidectomy and excision of obvious local metastatic disease, followed by 131 I ablation of any residual tumor and subsequent thyroid therapy, had the best prognosis. CrossrefMedlineGoogle Scholar36. SCHIMMELUTIGER MR: Thyroidal and peripheral production of thyroid hormones. Review of recent findings and their clinical implications. Ann Intern Med 87:760-768, 1977 Current information concerning thyroidal and peripheral thyroid hormone production and the changes in triiodothyronine and reverse triiodothyronine production that occur in patients with thyroid and nonthyroid illness. LinkGoogle Scholar37. SCHNEIDERFAVUSSTACHURAARNOLDARNOLDFROHMAN AMMJML: Incidence, prevalence and characteristics of radiation-induced thyroid tumors. Am J Med 64:243-252, 1978 This article describes the results of the most extensive recall program for patients who underwent head and neck irradiation in infancy and childhood. CrossrefMedlineGoogle Scholar38. SOLOMONCHOPRACHOPRASMITH DIUF: Identification of subgroups of euthyroid Graves's ophthalmopathy. N Engl J Med 296:181-186, 1977 From careful studies of thyroid function and regulation and thyroid-stimulating antibody tests, the authors conclude that patients with euthyroid Graves' ophthalmopathy may have Graves' thyroid disease, Hashimoto's disease, or only "isolated" ophthalmopathy. CrossrefMedlineGoogle Scholar39. VAGENAKISBRAVERMANAZIZIPORTNAYINGBAR ALEGS: Recovery of pituitary thyrotropic function after withdrawal of prolonged thyroid-suppression therapy. N Engl J Med 293:681-684, 1975 Endogenous thyroid-stimulating hormone and thyroid secretion are suppressed during thyroid hormone therapy. When such therapy is discontinued, 4 to 6 weeks are required before normal pituitary and thyroid function returns. The limiting factor is recovery of thyroid-stimulating hormone, rather than thyroid, secretion. CrossrefMedlineGoogle Scholar40. BARROTH RJ: Insulin receptor status in disease states of man. Arch Intern Med 137:474-481, 1977 Overview of the receptor concept, especially as it applies to insulin, with description of factors regulating receptors in vivo and in vitro and of the nature of circulating receptor antibodies. CrossrefMedlineGoogle Scholar41. CUDWORTH A: Type I diabetes mellitus. Diabetologia 14:281-291, 1978 Review of the immunologic and genetic criteria by which insulin-dependent, ketosis-prone diabetics are differentiated from their non-ketosis-prone, insulin-independent counterparts. CrossrefMedlineGoogle Scholar42. : Preliminary report on effects of photocoagulation therapy. Am J Ophthalmol 81:383-396, 1976 Analyses of visual activity and visual fields provide evidence that photocoagulation treatment is beneficial in preventing severe visual loss during a 2-year follow-up period in patients with proliferative retinopathy. CrossrefMedlineGoogle Scholar43. IRVINEMCCALLUMGRAYCAMPBELLDUNCANFARQUARVAUGHANMORRIS WCRCLJHP: Pancreatic islet-cell antibodies in diabetes mellitus correlated with the duration and type of diabetes, coexistent autoimmune disease and HLA type. Diabetes 26:138-147, 1977 A comprehensive study of the prevalence of cytoplasmic islet cell antibodies in insulin-dependent diabetes correlated with patient age, duration of disease, sex, and HLA-type. CrossrefMedlineGoogle Scholar44. KAHNFLIERBARARCHERGORDENMARTINROTH CJRJPMJ: The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. N Engl J Med 294::739-745, 1976 Insulin resistance in two groups of women is described: Type A is in younger women with signs of virilization or accelerated growth with deficiency of insulin receptors; type B is in older women with autoimmune disease and circulating insulin receptor antibodies. CrossrefMedlineGoogle Scholar45. KREISBERG R: Diabetic ketoacidosis: new concepts and trends in pathogenesis and treatment. Ann Intern Med 88:681-695, 1978 Comprehensive review of the metabolic aberrations and pathophysiology of this disorder, including guidelines for therapy and review of the problem of alcoholic ketoacidosis. LinkGoogle Scholar46. KUSSMANGOLDSTEINGLEASON MHR: The clinical course of diabetic nephropathy. JAMA 236:1861-1863, 1976 The mean duration of diabetes at onset of proteinuria was 17 ± 6 years in the patients studied, all of whom subsequently experienced progressive deterioration in renal func- tion. Juvenile-onset diabetic patients should be considered for transplantation before their serum creatinine levels reach 8.5 mg/dL. CrossrefMedlineGoogle Scholar47. LONGSTRETHNEWCOMER GA: Abdominal pain caused by diabetic radiculopathy. Ann Intern Med 86:166-168, 1977 Abdominal pain due to radiculopathy occurred in four patients who presented with features suggestive of abdominal malignancy. Electromyographic examination revealed the correct diagnosis, and spontaneous recovery occurred in all. LinkGoogle Scholar48. MCGARRYFOSTER JD: Hormonal control of ketogenesis. Biochemical considerations. Arch Intern Med 137:495501, 1977 Review of the bihormonal concept of ketogenesis involving insulin deficiency and relative glucagon excess coupled with the activation of carnitine acyl transferase, the first step in the oxidation of fatty acids to ketone bodies. CrossrefMedlineGoogle Scholar49. MOLNAR G: Clinical evaluation of metabolic control in diabetes. Diabetes 27 (suppl 1):216-225, 1978 Methods for assessing diabetic control are reviewed and their advantages and limitations evaluated. The relative importance of abnormalities in blood and urinary glucose, as well as circulating amino acid, lipid, and hemoglobin AIc levels are described. CrossrefMedlineGoogle Scholar50. RIZZAGERICH RJ: Somatostatin and diabetes. Med Clin North Am 62:735-746, 1978 Somatostatin acts as a local regulator of endocrine and exocrine secretion and may have a physiologic role in the regulation of islet A and B cell function, which may be disturbed in diabetes. CrossrefMedlineGoogle Scholar51. ROTTERRIMOIN IL: Heterogeneity in diabetes mellitus—update, 1978. Evidence for further genetic heterogeneity within juvenile-onset insulin-dependent diabetes mellitus. Diabetes 27:599-608, 1978 A review of the genetic heterogeneity of diabetes with attention to immunologic and HLA studies. Insulin-dependent is separated from insulin-independent diabetes, and the heterogeneity within the insulin-dependent group is described. CrossrefMedlineGoogle Scholar52. STEINER D: Insulin today. Diabetes 26:322-340, 1977 Excellent review of the discovery of proinsulin, preproinsulin, and the intracellular pathway of insulin biosynthesis, which provides the background for understanding recent advances in isolating the gene for preproinsulin and its incorporation into bacteria. CrossrefMedlineGoogle Scholar53. UNGERORCI RL: Role of glucagon in diabetes. Arch Intern Med 137:482-491, 1977 The bihormonal control of glucoregulation and the regulation of fuel distribution are mediated by circulating glucagon and insulin concentrations. The contribution of abnormal glucagon levels to the diabetic state is described. CrossrefMedlineGoogle Scholar54. AHRENS E: The management of hyperlipidemia: whether, rather than how. Ann Intern Med 85:87-93, 1976 The premise that measures used to lower plasma lipid levels in patients with hyperlipidemia will reduce morbidity from coronary heart disease (the lipid hypothesis) is provocatively reanalyzed in light of recent dietary and drug intervention studies. LinkGoogle Scholar55. BROWNGOLDSTEIN MJ: Familial hypercholesterolemia: a genetic defect in the low-density lipoprotein receptor. N Engl J Med 294:1386-1390, 1976 Implications of the discovery of the low-density lipoprotein receptor defect in familial hypercholesterolemia are reviewed. The elucidation of the low-density lipoprotein pathway in cells and its potential role in vivo are concisely described. CrossrefMedlineGoogle Scholar56. BRUNZELLCHAITBIERMAN JAE: Pathophysiology of lipoprotein transport. Metabolism 27:1109-1127, 1978 A simple pathophysiologic classification of hyperlipidemic states based on known defects in the regulation of lipoprotein transport is described and placed in diagnostic perspective of genetic and secondary hyperlipidemias. CrossrefMedlineGoogle Scholar57. BRUNZELLSCHROTTMOTULSKYBIERMAN JHAE: Myocardial infarction in the familial forms of hypertriglyceridemia. Metabolism 25:313-320, 1976 The risk of coronary heart disease differs markedly in the two common monogenic forms of hypertriglyceridemia. Regardless of the lipoprotein abnormality, an affected individual with familial combined hyperlipidemia is likely to develop myocardial infarction before age 50. CrossrefMedlineGoogle Scholar58. FISHERTRUITT WD: The common hyperlipoproteinemias. An understanding of disease mechanisms and their control. Ann Intern Med 85:497-508, 1976 Comprehensive review of the physiologic role of low-density lipoproteins and very low-density lipoproteins as transporters of cholesterol and triglyceride and the clinical manifestations of the common primary hyperlipoproteinemias. LinkGoogle Scholar59. GLUECKGARTSIDESTEINERMILLERTODHUNTERHAAFPUCKETERRANAFALLATKASHYAP CPPMTJMMRM: Hyperalpha- and hypobeta-lipoproteinemia in octogenarian kindreds. Atherosclerosis 27:387-406, 1977 The association of longevity with a familial aggregation of either elevated levels of high-density lipoproteins or reduced low-density lipoproteins is documented. Average life expectancy for persons in these families exceeds that of the general population by more than 10 years. CrossrefMedlineGoogle Scholar60. HAVEL R: Classification of the hyperlipidemias. Annu Rev Med 28:195-209, 1977 Developments leading to our current understanding are summarized, emphasizing the primary hyperlipidemias. Various kinds of classification that can assist in patient management are reviewed. CrossrefMedlineGoogle Scholar61. KUSHWAHAHAZZARDGAGNECHAITALBERS RWCAJ: Type III hyperlipoproteinemia: paradoxical hypolipidemic response to estrogen. Ann Intern Med 87:517-525, 1977 Estrogens may facilitate assimilation of chylomicron and very low-density lipoprotein remnants in type III hyperlipoproteinemia (broad beta disease). Blocked remnant removal is the likely metabolic defect. LinkGoogle Scholar62. MOTULSKY A: Current concepts in genetics. The genetic hyperlipidemias. N Engl J Med 294:823-827, 1976 An up-to-date review of the genetic forms of hyperlipidemia emphasizing diagnosis, frequency, possible mechanisms, and implications regarding premature coronary heart disease. CrossrefMedlineGoogle Scholar63. SABESINHAWKINSKUIKENRAGLAND SHLJ: Abnormal plasma lipoproteins and lecithin-cholesterol acyltransferase deficiency in alcoholic liver disease. Gastroenterology 72:510-518, 1977 Acute alcoholic fatty liver produces a complex defect in lipoprotein metabolism associated with lecithin-cholesterol acyltransferase deficiency. Cholesterol esters and high-density lipoprotein levels are low, and an abnormal triglyceriderich low-density lipoprotein particle accumulates. CrossrefMedlineGoogle Scholar64. STARZLPUTNAMKOEP TCL: Portacaval shunt and hyperlipidemia. Arch Surg 113:71-74, 1978 Review of the rationale, clinical effects, and possible mechanism of portacaval shunts as used in lowering serum cholesterol and low-density lipoprotein levels in patients with homozygous familial hypercholesterolemia. CrossrefMedlineGoogle Scholar65. YESHURUNGOTTO DA: Drug treatment of hyperlipidemia. Am J Med 60:379-396, 1976 Use, actions, and side-effects of drugs used in the therapy of hyperlipidemia. CrossrefMedlineGoogle Scholar66. BRAYBENFIELD GJ: Intestinal bypass for obesity: a summary and perspective. Am J Clin Nutr 30:121-127, 1977 Comprehensive survey of the uses and complications of intestinal bypass surgery for obesity. CrossrefMedlineGoogle Scholar67. CHARNEYGOODMANMCBRIDELYONPRATT EHMBR: Childhood antecedents of adult obesity. Do chubby infants become obese adults? N Engl J Med 295:6-9, 1976 A retrospective study providing evidence that weight in infancy before age 6 months correlates strongly with adult weight independent of other factors. CrossrefMedlineGoogle Scholar68. JOHNSONDRENICK DE: Therapeutic fasting in morbid obesity. Long-term follow-up. Arch Intern Med 137:13811382, 1977 Long-term follow-up of 207 grossly obese patients who lost up to 45.4 kg by total fasting. Fifty percent returned to starting weight within 3 years, and fewer than 10% maintained weight loss 9 years later. CrossrefMedlineGoogle Scholar69. KNITTLEGINSBERG-FELLNERBROWN JFR: Adipose tissue development in man. Am J Clin Nutr 30:762-766, 1977 A detailed cross-sectional and longitudinal study of adipose cell number as a function of age in obese and nonobese children from ages 2 to 16. The data document continuing adipose cell hyperplasia in the obese throughout childhood. CrossrefMedlineGoogle Scholar70. LAW D: Current concepts in nutrition. Total parenteral nutrition. N Engl J Med 297:1104-1107, 1977 Comprehensive review of the uses, techniques, and complications of total parenteral alimentation. CrossrefMedlineGoogle Scholar71. REISENABELMODANSILVERBERGELIAHOUMODAN ERMDHB: Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patients. N Engl J Med 298:1-6, 1978 A careful study documenting remarkable falls in blood pressure in mildly hypertensive patients by weight loss alone. This change was accomplished by calorie but not salt restriction. CrossrefMedlineGoogle Scholar72. SCHWARTZBRUNZELL RJ: Increased adipose-tissue lipoprotein-lipase activity in moderately obese men after weight reduction. Lancet 1:1230-1231, 1978 Evidence is presented that increased adipose tissue lipoprotein-lipase activity in obese patients is a metabolic abnormality not corrected by weight reduction. This might be a primary abnormality leading to enhanced fat deposition. CrossrefMedlineGoogle Scholar73. AVIOLI L: Senile and postmenopausal osteoporosis. Adv Intern Med 21:391-415, 1976 A thorough and well-referenced discussion of one of the most perplexing disorders of skeletal homeostasis. MedlineGoogle Scholar74. BONESNYDERPAK HWC: Diagnosis of hyperparathyroidism. Annu Rev Med 28:111-117, 1977 Primary hyperparathyroidism is the other (in addition to malignancy) common cause of hypercalcemia. The changing clinical presentation of primary hyperparathyroidism is updated. CrossrefMedlineGoogle Scholar75. CANFIELDROSNERSKINNERMCWHORTERRESNICKFELDMANKAMMERMANRYANKUNIGONISBOHNE RWJJLFSKMW: Diphosphonate therapy of Paget's disease of bone. J Clin Endocrinol Metab 44:96-106, 1977 The efficacy of diphosphonates, the first orally effective agents for treating patients with Paget's disease, was documented in a double-blind protocol. CrossrefMedlineGoogle Scholar76. DEFTOS L: Calcitonin in clinical medicine. Adv Intern Med 23:159-193, 1978 Calcitonin secretion is valuable as a marker for medullary thyroid carcinoma, a component of the multiple endocrine neoplastic disorders. This article also reviews other clinically relevant secretory abnormalities of this hormone. MedlineGoogle Scholar77. DELUCA H: Recent advances in our understanding of the vitamin D endocrine system. J Lab Clin Med 87:7-26, 1976 A clear and concise discussion of the complex metabolism of vitamin D and its importance in clinical disorders of calcium and skeletal metabolism. MedlineGoogle Scholar78. FRASERSCRIVER DC: Familial forms of vitamin D-resistant rickets revisited. X-linked hypophosphatemia and autosomal recessive vitamin D dependency. Am J Clin Nutr 29:1315-1329, 1976 Simple vitamin D deficiency is no longer an adequate explanation for osteomalacia and rickets. This article reviews the abnormalities of vitamin D metabolism that can be responsible for inadequate mineralization of bone. CrossrefMedlineGoogle Scholar79. HABENERMAHAFFEY JJ: Osteomalacia and disorders of vitamin D metabolism. Annu Rev Med 29:327-342, 1978 Thorough review of the various disturbances in vitamin D metabolism and action that result in osteomalacia. CrossrefMedlineGoogle Scholar80. HEANEY R: Estrogens and postmenopausal osteoporosis. Clin Obstet Gynecol 19:791-803, 1976 A discussion of the role of estrogens in the management of postmenopausal osteoporosis. CrossrefMedlineGoogle Scholar81. KHAIRIDEXTERBURZYNSKIJOHNSTON MRNC: Mucosal neuroma, pheochromocytoma and medullary thyroid carcinoma: multiple endocrine neoplasia type 3. Medicine (Baltimore) 54:89-112, 1975 This thorough and up-to-date treatment of one of the multiple endocrine neoplastic disorders offers original data as well as a review of previous publications. CrossrefMedlineGoogle Scholar82. KNOCHEL J: The pathophysiology and clinical characteristics of severe hypophosphatemia. Arch Intern Med 137:203220, 1977 CrossrefMedlineGoogle Scholar83. MASSRYSEELIG SM: Hypomagnesemia and hypermagnesemia. Clin Nephrol 7:147-153, 1977 These two articles deal with normal and abnormal metabolism of phosphorus and magnesium, whose clinical disorders are becoming well-recognized contributors to a variety of disease states. MedlineGoogle Scholar84. MYERS W: Differential diagnosis of hypercalcemia and cancer. CA 27:258-272, 1977 Malignancy is one the commonest causes of hypercalcemia. This review discusses the increasingly complex and variable pathogenesis of this clinically important cause of hypercalcemia in such patients. Google Scholar85. PURNELLSCHOLZSMITHSIZEMOREBLACKGOLDSMITHARNAUD DDLGBRC: Treatment of primary hyperparathyroidism. Am J Med 56:800-809, 1974 A large group of patients with mild hypercalcemia due to uncomplicated primary hyperparathyroidism were followed without treatment. Disease progression occurred in only 20% in 5 years. Results of surgical and medical treatment (with oral phosphate) of this disorder are also described. CrossrefMedlineGoogle Scholar86. SEYBERTHSEGREMORGANSWEETMANPOTTSOATES HGJBJJ: Prostaglandins as mediators of hypercalcemia associated with certain types of tumors. N Engl J Med 293:1278-1283, 1975 A study of 29 patients with solid tumors, 14 of whom were hypercalcemic. Twelve of the hypercalcemic patients had increased urinary prostaglandin excretion; six treated with indomethacin or aspirin had decreases in serum calcium and urine prostaglandin excretion. CrossrefMedlineGoogle Scholar87. SIZEMORECARNEYHEATH GJH: Epidemiology of medullary carcinoma of the thyroid gland: a 5-year experience (1971-1976). Surg Clin North Am 57:633-645, 1977 This paper summarizes the experience of a group that has been following large kindreds with a multiple endocrine neoplastic disorder. Female Reproduction CrossrefMedlineGoogle Scholar88. EDMONDSONREYNOLDSHENDERSONBENTON HTBB: Regression of liver cell adenomas associated with oral contraceptives. Ann Intern Med 86:180-182, 1977 Benign hepatic cell adenomas have been described with increasing frequency in patients receiving estrogen therapy. This paper describes patients with such tumors in whom cessation of estrogen therapy was associated with regression and disappearance of the tumors. LinkGoogle Scholar89. HASKALLSPARKSGRAZEKORENMAN CFPS: Systemic therapy for metastatic breast cancer. Ann Intern Med 86:68-80, 1977 The introduction of estrogen receptor assay has resulted in more rational selection of hormonal or drug therapy for patients with metastatic breast cancer. This article reviews the current information in this area. LinkGoogle Scholar90. HEMSELLGRODINBRENNERSIITERIMACDONALD DJPPP: Plasma precursors of estrogen. II. Correlation of the extent of conversion of plasma androstenedione to estrone with age. J Clin Endocrinol Metab 38:476-479, 1974 Estrogens in postmenopausal women are produced largely by conversion (aromatization) of precursor steroids, mainly androstenedione, to estrogens in peripheral tissues, including adipose tissue and muscle. This study shows that conversion increases with age and with body weight. CrossrefMedlineGoogle Scholar91. KIRSCHNERZUCKERJESPERSEN MID: Idiopathic hirsutism in an ovarian abnormality. N Engl J Med 294:637640, 1976 Adrenal and ovarian vein catheterization studies were done in 44 women with hirsutism. Androgen excess was largely of ovarian origin and was suppressible by glucocorticoid therapy in many patients. CrossrefMedlineGoogle Scholar92. MARSHALLREEDGORDON JPH: Luteinizing hormone secretion in patients presenting with post-oral contraceptive amenorrhea: evidence for a hypothalamic feedback abnormality. Clin Endocrinol (Oxf) 5:131-143, 1976 Of 24 patients with "post-pill" amenorrhea, 14 had readily recognizable explanations including polycystic ovarian disease and pituitary tumors. In the remainder, abnormalities in gonadotropin secretion suggested continued gonadotropin suppression. Thorough evaluation of patients with post-pill amenorrhea is necessary. CrossrefMedlineGoogle Scholar93. VESSEYDOLLPETOJOHNSONWIGGINS MRRBP: A long-term follow-up study of women using different methods of contraception—an interim report. J Biosoc Sci 8:373427,1976 This group initiated the earliest studies suggesting that estrogen-containing contraceptives increase the frequency of thromboembolism. This large epidemiologic study, which compares risk of contracting a number of diseases for different methods of contraception, is a basic reference on side-effects of estrogen-containing medications. CrossrefMedlineGoogle Scholar94. AMRHEINJONES KLINGENSMITHWALSHMCKUSICKMIGEON JGPVC: Partial androgen insensitivity. The Reifenstein syndrome revisited. N Engl J Med 297:350-356, 1977 Previously believed to be a congenital disorder of genital and testicular development, this syndrome is now known to represent a broad spectrum of abnormalities in androgen sensitivity. This paper reviews the variable clinical presentation and pathophysiology of this disorder. CrossrefMedlineGoogle Scholar95. GORDONALTMANSOUTHRENRUBINLIEBER GKAEC: Effect of alcohol (ethanol) administration on sex-hormone metabolism in normal men. N Engl J Med 295:793797, 1976 Alcohol administration resulted in decreased testosterone production, but little increase in serum luteinizing hormone. Thus alcohol affects both the gonad and the hypothalamuspituitary and changes in gonadal steroid metabolism in men with alcoholic liver disease may be due largely to toxic effects of alcohol per se. CrossrefMedlineGoogle Scholar96. ODELLSWERDLOFF WR: Abnormalities of gonadal function in men. Clin Endocrinol (Oxf) 8:149-180, 1978 This review covers current concepts of the physiology and endocrinology of testicular control mechanisms, as well as classification, pathogenesis, and diagnosis of hypogonadal states in men. CrossrefMedlineGoogle Scholar97. SHERINSOLWENYZIEGLER RCJ: Gynecomastia and gonadal dysfunction in adolescent boys treated with combination chemotherapy for Hodgkin's disease. N Engl J Med 299:12-16, 1978 Various antitumor drugs impair spermatogenesis, and some also reduce testosterone production. Chemotherapyrelated hypogonadism is likely to become common in the future. CrossrefMedlineGoogle Scholar98. WACHTELKOOBREGTHALERDILLARDROSENTHALDOSIKGERALDSAENGERNEWLIEBERMILLER SGWHGIHPPMEO: Serologic detection of a Ylinked gene in XX males and XX true hermaphrodites. N Engl J Med 295:750-754, 1976 Y chromosome material was detected in phenotypic males with XX karyotype and in XX true hermaphrodites. Previously the XX male appeared to be an exception to the concept that development of male phenotype required Y chromosome activity. This concept remains true, and these XX syndromes are associated with presence of Y chromosome material translocated to another chromosome. CrossrefMedlineGoogle Scholar99. ODELLWOLFSEN WA: Humoral syndromes associated with cancer. Annu Rev Med 29:379-406, 1978 Virtually every peptide hormone may be produced by nonendocrine tumors, and hormone overproduction may contribute to morbidity in patients with neoplastic disease. This article reviews these hormonal syndromes, their incidence, and their pathogenesis. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: AMERICAN COLLEGE OF PHYSICIANS Philadelphia, Pennsylvania*Robert D. Utiger, M.D., Chairman; Edwin L. Bierman, M.D.; Leonard J. Deftos, M.D.; Colum A. Gorman, M.D.; William D. Odell, M.D., Ph.D.; Arthur H. Rubenstein, M.D.; and Gordon H. Williams, M.D.†Computer literature-file of the National Library of Medicine, Bethesda, Maryland, consulted through the Regional Medical Library service Library of the College of Physicians of Philadelphia, with the technical assistance of Ruthanne Henner. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1979Volume 90, Issue 4Page: 726-731KeywordsComputersEndocrinologyLibraries ePublished: 1 December 2008 Issue Published: 1 April 1979 PDF downloadLoading ...