tbuckley/cabot-search huggingface dataset:
Some Effects of the Tumor Promoter 12-&lt;italic&gt;O&lt;/italic&gt;-Tetradecanoylphorbol 13-Acetate on Cell Interactions In Vitro&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1982)

Studies were made of the effects of the potent tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA), 4-O-methyl TPA (4-O-MeTPA), and 4αphorbol 12,13-didecanoate (4αPDD) on the aggregation of embryonic chick cells in gyratory shaker culture, a model system useful for the study of cell adhesion and cell interactions. TPA and, to a lesser extent, 4-O-MeTPA significantly reduced the neural retina aggregate size at concentrations as low as 10−9M and 10−8M, respectively. An inactive isomer, 4αPDD, had no effect up to 10−6M. The reduction in aggregate size appeared related to promoter activity since dexamethasone, a steroid that inhibits tumor promotion by TPA, significantly reversed the inhibitory effect of TPA. None of the agents tested affected the sorting pattern in mixed neural retina and heart cultures. The results indicate that intercellular adhesion, as determined by extent of aggregation, is reduced in the presence of TPA. This inhibition is considered to be related to the tumor-promoting activity of TPA.
Desocializing Health Care in a Developing Country
Authors: Richard Garfield
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chromosomal Abnormalities in Certain Human Malignancies
Authors: Sheldon K. Gottlieb
Journal: JAMA (1969)

The association of the Philadelphia chromosome with chronic myelocytic leukemia is well known, but the association of the Christchurch chromosome with chronic lymphocytic leukemia, the Philadelphia (or Philadelphia-like) chromosome with acute myeloblastic leukemia, the Melbourne chromosome with malignant lymphomas, the Madison chromosome with nonepithelial tumors, a long marker chromosome with testicular tumors, and double minute chromatin bodies with childhood tumors are not widely known or agreed upon. These chromosomal abnormalities are but a few of the many reported in the literature. Karyotypic changes are not always seen at the level of the light microscope. Whether chromosomal abnormalities are important in the initiation of neoplasia or not, their identification may be useful in the diagnosis, prognosis, and therapeutic management of some patients with cancer.
Endoscopy International Open – recently published
Journal: Endoscopy (2015)

See also: Biophotonic endoscopy: a review of clinical research techniques for optical imaging and sensing of early gastrointestinal cancerEndosc Int Open 2015; 03(05): E380-E392DOI: 10.1055/s-0034-1392513 See also: Novel strategy of endoscopic submucosal dissection using an insulation-tipped knife for early gastric cancer: near-side approach methodEndosc Int Open 2015; 03(05): E425-E431DOI: 10.1055/s-0034-1392567 See also: Development of a device for detecting target specimens from EUS-guided FNA samplesEndosc Int Open 2015; 03(06): E662-E664DOI: 10.1055/s-0034-1393076
Lactation and Reproductive Histories of Breast Cancer Patients in Boston, 1965–66&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1969)

Journal Article Lactation and Reproductive Histories of Breast Cancer Patients in Boston, 1965–66 Get access Eva J. Salber, M.D., Eva J. Salber, M.D. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115 Search for other works by this author on: Oxford Academic PubMed Google Scholar Dimitrios Trichopoulos, M.D., Dimitrios Trichopoulos, M.D. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115 Search for other works by this author on: Oxford Academic PubMed Google Scholar Brian MacMahon, M.D. Brian MacMahon, M.D. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 43, Issue 5, November 1969, Pages 1013–1024, https://doi.org/10.1093/jnci/43.5.1013 Published: 01 November 1969 Article history Received: 04 February 1969 Accepted: 28 July 1969 Published: 01 November 1969
Arrhythmias Related to Coffee and Tea
Authors: John T. Flynn
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Tucked away in the first line of the quotation in "The Other End of the Stick" (<b>210:</b>896, 1969) is an account of a common error in the management of myocardial infarction. The words, "I was sitting up in bed after tea," do not necessarily mean in British vernacular that the patient in reality had consumed tea, but within the broader meaning of the words, no doubt a beverage containing caffeine or theophylline was consumed together with other goodies. Since tea and coffee are well known to produce minor cardiac arrhythmias, particularly ventricular premature contractions, it is not surprising that an episode of a more serious arrhythmia might have developed shortly after the patient consumed his "tea." It has always amazed me that tea, coffee, and occasionally cola drinks are consumed by patients in a coronary care unit, when so much other effort is directed by the
The Postmenopausal Estrogen/Breast Cancer Controversy
Authors: Rena Vassilopoulou-Sellin
Journal: JAMA (1993)

<h3>To the Editor.</h3> —As Dr Henrich<sup>1</sup>persuasively points out, there remains no compelling evidence that use of postmenopausal estrogen replacement therapy (ERT) places women at increased risk for the development of breast cancer. While criteria for the rational administration of estrogen are being defined for the general population of postmenopausal women who may benefit from ERT during the latter decades of their lives, guidelines do not exist for the growing number of women who have had the diagnosis of breast cancer at some point before the development of menopause. Postmenopausal estrogen deficiency places all women, including those who have been treated for breast cancer, at increased risk for osteoporosis and heart disease. However, because of theoretical concerns that estrogen may adversely affect the course of breast cancer, ERT has not been considered appropriate for this latter group of patients.<sup>2</sup>Thus, an ever-increasing number of young, postmenopausal women with
Pharmacology and Therapeutics.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pathogenesis of Tumors Induced With &lt;italic&gt;N&lt;/italic&gt;-Nitrosomethylpiperazine in the Olfactory Region of the Rat Nasal Cavity&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN4"&gt;4&lt;/xref&gt;
Authors: Hildegard M. Reznik-Schüller
Journal: JNCI Journal of the National Cancer Institute (1983)

Tumors in the olfactory region of the nasal cavity of the F344 rat were induced by chronic treatment with N-nitrosomethylpiperazine. The pathogenesis of the neoplasms was studied in a serial sacrifice study by light and electron microscopy. Proliferating basal cells of the olfactory epithelium differentiated into cells with morphologic features of neuroendocrine cells, which then progressed further to become invasive carcinomas. The tumors exhibited areas of neuroendocrine, adenoid, squamous, and neuroblastic morphologies. The variability of morphologic patterns found within the same tumor can be explained by the ability of neuroendocrine cells to differentiate into these different cell types.
Tests for Chemical Carcinogens. Report on the Activity of Derivatives of Aromatic Amines, Nitrosamines, Quinolines, Nitroalkanes, Amides, Epoxides, Aziridines, and Purine Antimetabolites&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1968)
Croonian Lectures on Matter and Force
Authors: H. B. Jones
Journal: BMJ (1868)

On the Three Stagv ofour Ideas regarding the Union of Bautter and Fovope in the Abiological Sciences."But though the nai works of God can never by an ossibility corn in e nyon with thi higer things which belong to our fiture existence,.and Lf Ith eerythihg oirning hnm ever glorifyhm, still I do not think it at all lcessomy tWtieitstudy of the natural sciences and religion together."
Definitions of the Metabolic Syndrome—Reply
Authors: Hanna-Maaria Lakka, David E. Laaksonen, Timo A. Lakka, Leo K. Niskanen, Esko Kumpusalo, Jaakko Tuomilehto, Jukka T. Salonen
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A ROYAL ARMY MEDICAL CORPS.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Malignant and Transforming Activity of Rous Sarcoma Virus (RSV). III. Detection of Tumor-Specific Transplantation and Membrane Antigens in Mouse Cell Lines Transformed <italic>In Vitro</italic> by RSV
Authors: I. N. Kryukova, O. Y. Babkova, I. B. Obukh
Journal: JNCI Journal of the National Cancer Institute (1971)

The tumor-specific transplantation antigen (TSTA) and cell membrane-specific antigen (MSA) were studied in 2 mouse embryo cell lines transFormed by Rous sarcoma virus (RSV). These cell lines were morphologically transFormed in vitro by RSV and lost tumor-producing activity in syngeneic hosts. The isograft-rejection test, cytotoxic reaction of target cells with sensitized lymphoid cells in vitro, and the indirect immunofluorescent technique on living cells showed that one line was immunologically more responsive than the other. The loss of tumor-producing activity was not correlated with the induction of high levels of TSTA or MSA. A new membrane antigen was detected in the cell membranes of both transformed cell lines with an immunofluorescent technique using sera against the transFormed cells. Its appearance coincides with the inFection of mouse embryo cells with RSV.
Medical Examinations and Licensure
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reactions to Local Anesthetics
Authors: John Adriani
Journal: JAMA (1966)

Local anesthetics are used widely by practically all physicians, most of whom are not fully aware of the lethal potential of local anesthetics and the swiftness with which they may precipitate a catastrophe. The perineural concentration of a local anesthetic necessary to interrupt conduction in a nerve fiber is many times greater than that which a patient will tolerate if that drug is circulating in the plasma. The majority of clinically useful local anesthetics are tertiary amines and are, therefore, basic substances.<sup>1</sup>They form aqueous solutions that are alkaline in reaction. The bases are poorly soluble in water, but they readily form water soluble salts with acids. The bases are less stable than the salts. The salts, by virtue of their greater solubility and stability, are used for injection and topical application. Although aqueous solutions of the salts are acid in reaction, when injected they are converted to the
The Organs of Internal Secretion: Their Diseases and Therapeutic Application. A Book for General Practitioners.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pneumonia Caused by Neisseria meningitidis
Authors: Samuel A. Jacobs
Journal: JAMA (1974)

Neisseria meningitidis,<i>group Y, was isolated from the blood and sputum of a young man with pneumonia. No potentially predisposing factors such as abnormal hemoglobins or preceding viral infection were detected. A fourfold rise in hemagglutinating antibody titers to group Y meningococcal antigen was observed</i>.
Sports-Related Injuries Among High School Athletes—United States, 2005-06 School Year
Journal: JAMA (2006)

Participation in high school sports helps promote a physically active lifestyle. High school sports participation has grown from an estimated 4 million participants during the 1971-72 school year to an estimated 7.2 million in 2005-06. However, despite the documented health benefits of increased physical activity (e.g., weight management, improved self-esteem, and increased strength, endurance, and flexibility), those who participate in athletics are at risk for sports-related injuries. High school athletes account for an estimated 2 million injuries, 500,000 doctor visits, and 30,000 hospitalizations annually. To date, the study of these injuries has been limited by inabilities to calculate injury rates, compare results among groups, and generalize findings from small, nonrepresentative samples. During the 2005-06 school year, researchers at a children's hospital in Ohio used an Internet-based data-collection tool to pilot an injury surveillance system among athletes from a representative national sample of U.S. high schools. This report summarizes the findings of that study, which indicated that participation in high school sports resulted in an estimated 1.4 million injuries at a rate of 2.4 injuries per 1,000 athlete exposures (i.e., practices or competitions). Surveillance of exposure-based injury rates in a nationally representative sample of high school athletes and analysis of injury patterns can help guide activities aimed at reducing these injuries.
What Is Necessary for Proof? Is 95% Sure Unrealistic?
Authors: Robert L. Wears
Journal: JAMA (1994)

<h3>To the Editor.</h3> —The discussion by Dr Eddy<sup>1</sup>of what is needed for evidence to be "sufficient" when evaluating medical treatments deserves further exploration. Even if we can agree on appropriate end points, study designs, and use of expert knowledge, the question of how certain we must be that treatment A is beneficial compared with treatment B is still
Lung Dust Lesions Versus Tuberculosis
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ANTITOXIN TREATMENT OF DIPHTHERIA.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal