tbuckley/cabot-search huggingface dataset:
Bone Marrow Transplantation for Acute Myeloblastic Leukemia
Authors: Mortimer M. Bortin
Journal: JAMA (1978)

Fifty-seven patients with end-stage acute myeloblastic leukemia (AML) received a total of 65 bone marrow transplants between 1968 and 1976. Marrow from HLA genotypically identical allogeneic donors was administered to 32 patients, 13 received marrow from HLA-incompatible donors, donorrecipient HLA compatibility was undetermined for eight patients, and identical twins were marrow donors for four patients. None of the patients in the three latter groups survived beyond 9.4 months after transplantation. Two patients treated with marrow transplants from HLA-compatible donors currently are alive and free of leukemia with functioning grafts 13 and 38 months after transplantation. The 32 patients in the Registry series who received marrow from HLA-compatible donors were compared with a similar series of 46 patients in Seattle. Data for these 78 patients were pooled and analyzed for pretransplant factors that might have prognostic value. Patients with end-stage AML had approximately a 10% chance of surviving 20 months after high-dose chemoradiotherapy plus marrow transplantation. Patients younger than 21 years had a higher six-month survival rate than patients older than 30 years. Patients in the Registry series who received transplants with HLA-compatible marrow within eight months of diagnosis had a higher survival experience than patients who received transplants later. (<i>JAMA</i>240:1245-1252, 1978)
Practical Text-Book of Midwifery for Nurses.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rubens and the Question of Antiquity of Rheumatoid Arthritis
Authors: Thierry Appelboom
Journal: JAMA (1981)

Analysis of the hands in paintings attributed to Peter Paul Rubens during the last 30 years of his life seems to show progressive rheumatoid arthritis. Not only does this suggest that rheumatoid arthritis was present at the time, 200 years before some modern authors are willing to date its appearance, but also that Rubens or a major and consistent collaborator suffered from the disease. (<i>JAMA</i>1981;245:483-486)
Familial Urinary Tract Anomalies
Authors: Jo Leigh Simpson
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Familial occurrence of a given disorder may provide the first indication that genetic factors are of importance in its etiology. Our purposes here are (1) to provide the references to previously published reports concerning the uropathies and anomalies of the ureters and bladder and (2) to record some personal observations of familial urinary tract anomalies, thus, raising a question concerning the possible importance of heredity in this group of disorders. Hydronephrosis without hydroureters, suggesting uretero-pelvic junction obstruction, has been observed in sibs<sup>1</sup>and in two<sup>2,3</sup>and three<sup>4,5</sup>generations of families; in two<sup>1,3</sup>of these families aberrant renal vessels were described. Hydronephrosis accompanied by hydroureters,<sup>6</sup>ureterocele,<sup>7</sup>bladder neck obstruction,<sup>8</sup>or posterior urethral valves<sup>9,10</sup>has occurred in sibs or twins. Familial occurrence of ectopic ureteral insertion<sup>11</sup>and duplication of the collecting system<sup>2,12-15</sup>have also been observed. Lenz<sup>2</sup>refers
Designing Appropriate Therapy in the Treatment of Gram-Negative Bacillary Meningitis
Authors: Michael L. Corrado
Journal: JAMA (1982)

Gram-negative bacillary meningitis is being diagnosed more frequently, and the introduction of newer β-lactam antibiotics has contributed significantly to successful therapy. These new agents—because of their ease of administration and relative safety—also allow nonspecialists to treat the disease. There are, however, pitfalls in therapy of infections due to this heterogenous group of organisms. Extremely susceptible organisms, such as<i>Escherichia coli</i>and<i>Klebsiella pneumoniae</i>, most often respond to cephalosporin monotherapy, whereas relatively resistant organisms such as<i>Acinetobacter</i>and some<i>Enterobacter</i>may not. In these cases, combination therapy with an aminoglycoside is warranted. Testing the infecting organism for antibiotic susceptibility at the appropriate inoculum and pH may be useful in predicting therapeutic outcome. (<i>JAMA</i>1982;248:71-74)
Innovative Techniques for Teaching Psychiatric Principles to General Practitioners
Authors: Hugh J. Lurie
Journal: JAMA (1972)

The need for general physicians to improve their skills and effectiveness in helping patients with emotional difficulties has become more and more urgent in recent years. This problem has been of increasing concern to the American Academy of Family Physicians (AAFP); the National Institute of Mental Health (NIMH) has generously supported new programs; and surveys of physicians, such as those conducted by the Western Interstate Commission for Higher Education (WICHE),<sup>1-3</sup>have pinpointed the specific needs and have suggested fresh approaches. In attempting to inaugurate suitable physician education programs in this field, it has become increasingly apparent that emotional involvement by the physician in his own teaching and learning experience is essential if he is to change his style of counseling in practice and increase his diagnostic and interviewing skills.<sup>4-6</sup>In short, teaching psychiatric skills to general physicians must, at least to some extent, be "experiential." Such techniques are
Relationship Between Urethan Dose Rate and Adenoma Latency: Relevance of Tumor Growth Rate and Target Cell Number<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref><xref ref-type="fn" rid="FN4">4</xref>
Authors: Ellen J. O' Flaherty, Michael L. Dourson
Journal: JNCI Journal of the National Cancer Institute (1982)

Outbred Swiss Cox mice of both sexes were chronically exposed to urethan added to their drinking water at levels of 0.02-0.10% by weight. The number and sizes of lung adenomas that developed as a result were monitored as functions of time and dose rate (DR). The relationship between dose per unit time, or DR, and time (t,) needed for the development of a mean of one observable tumor per mouse was: DR × tn1 = K, where K and n are constants. The value of n was 2.75. This value could be largely accounted for by the DR-independent tumor growth time, although an increase in the number of target cells at higher urethan dose rates may also be a factor in the relationship between DR and t1. Examination of the relationships between cumulative incidence and DR and between cumulative incidence and adenoma induction time suggests that urethan acts at one stage of a two-stage mechanism in the induction of mouse lung adenomas.
Plasma fatty acids and lipid hydroperoxides increase after antibiotic therapy in cystic fibrosis
Authors: I. Durieu, F. Abbas-Chorfa, J. Drai, J. Iwaz, J-P. Steghens, M. Puget, R. Ecochard, G. Bellon
Journal: European Respiratory Journal (2007)

The present authors investigated whether cystic fibrosis is linked to a defect in fatty acids and assessed the impact of the main patients' characteristics on the levels of several fatty acids, mostly during respiratory exacerbation and after antibiotic therapy. Fatty acid phospholipid and cholesteryl ester levels were measured in stable-state patients and controls. No differences were found concerning either the fractions of palmitic and oleic acids or the cholesteryl esters of α-linolenic and arachidonic acids. However, phospholipids of α-linolenic and arachidonic acids, as well as cholesteryl esters and phospholipids of stearic and linoleic acids, were lower in patients than in controls, but fractions of dihomo-γ-linolenic, docosatetraenoic, docosapentaenoic, palmitoleic and eicosatrienoic acids were higher. Fatty acid levels, oxidative stress markers, nutrients, body mass index and forced expiratory volume in one second (FEV 1 ) were measured in patients before and after antibiotic courses for bronchial exacerbation. After adjustments, palmitic, stearic, α-linolenic, linoleic, arachidonic, palmitoleic and oleic acids generally decreased during exacerbation but almost all increased after antibiotic courses. Nearly all fractions increased along with FEV 1 and a positive relationship linked fatty acids to lipid hydroperoxides. There was no general drop in fatty acids. Patients' fatty acid profiles depended on the pulmonary function and the inflammation state.
Highlights of This Issue
Journal: Clinical Cancer Research (2013)

Chondrosarcomas are notoriously resistant to chemotherapy, and novel therapeutic targets are needed.Zhang and colleagues show strong S6 phosphorylation in the majority of chondrosarcoma tumors and heterogeneous activation of receptor tyrosine kinases (RTK) in cell lines.Inhibition of phosphoinositide-3-kinase (PI3K) and mTOR, signaling proteins downstream of RTKs and upstream of S6, potently blocked growth of chondrosarcoma cells in vitro and in vivo.A subset of chondrosarcoma was identified to harbor NRAS mutations, and a corresponding cell line responded to MEK inhibition.These findings provide a rationale for clinical exploration of PI3K/mTOR and MAPK pathway inhibitors in this disease.
Medical Schools in the United States
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Autonomic Dysreflexia in Injuries Below the Sixth Thoracic Segment
Authors: B. A. Moeller
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Autonomic dysreflexia with its many variations form an integral and troublesome way of life for spinal cord injury patients.<sup>1,2</sup>The attending physician must acquaint himself with these vagaries, if he is to avoid labeling all of his patients' complaints as psychosomatic or psychoneurotic manifestations. Bors and Comarr<sup>3</sup>state that, physiologically, all vascular segmental reflex activity is integrated at supraspinal levels of normal man, preventing extreme fluctuations of blood pressure. This integration of vasomotion is lost in patients with lesions of the neuraxis above the splanchnic outflow, ie, above levels between T-4 and T-6. It has been stated that autonomic dysreflexia occurs with lesions of the cord at the T-4 level and above. Also clinically significant autonomic reflex may be seen in patients with myelopathy cephalad to the sixth thoracic dermatome. Autonomic dysreflexia also may occur in lesions below the sixth segment. It has been the
The Impaired Physician
Authors: James H. Shore
Journal: JAMA (1982)

IN RECENT years, increased interest and attention have been focused on problems of emotionally impaired physicians. In response to concern for the impaired physician who is under formal probation, the Oregon Board of Medical Examiners initiated an evaluation of the rehabilitation programs for probationers with substance-use disorders and psychiatric illness. This article reports on the evaluation of these rehabilitation programs and addresses several questions concerning the effectiveness of rehabilitation efforts with impaired physicians. Those questions include the following: What are the problem types and risk groups of physicians who are on probation with the State Board of Medical Examiners for a psychiatric disorder? Is there a predictable course for the physician's illness? What is the physician's response to treatment? What is the preferred treatment plan for each major problem? In 1972, the American Medical Association's Council on Mental Health published its report on "The Sick Physician."<sup>1</sup>This initiated an
INTERACTION OF CELLS WITH IMMUNE COMPLEXES: ADHERENCE, RELEASE OF CONSTITUENTS, AND TISSUE INJURY
Authors: Peter M. Henson
Journal: The Journal of Experimental Medicine (1971)

Neutrophils are essential mediators of tissue damage in many forms of immune complex-induced injury. In vitro, they have been shown to release some of their content of injurious constituents upon reaction with immune complexes (Fig. 10). If the complexes are distributed along a nonphagocytosable surface, degranulation to the exterior of the cell is observed. When the complexes were phagocytized, however, degranulation into the phagocytic vacuole, and some loss of enzymes into the surrounding medium, occurred. This may have resulted from a momentary opening of the vacuole to allow ingestion of additional particles, as was demonstrated with the electron microscope. This phenomenon was particularly noticeable when the particles were relatively large. Far more immune complex is required to induce release when in a phagocytosable form than when on a nonphagocytosable membrane. Neutrophils may be attracted to sites of immune complex deposition in many parts of the body (arteries, heart, skin, brain, kidney, joints) by complement-mediated processes. In some situations, e.g. in the joint fluid, they would encounter free immune complexes, phagocytose them, and release enzymes. In many others, in which immune complexes may be distributed along surfaces, such as in the glomerulus, adherence of neutrophils may also lead to release of injurious constituents (proteases, collagenase, elastase, permeability factors) capable of digesting and injuring the tissues.
Long-Term Pervenous Atrial Pacing From the Proximal Portion of the Coronary Vein
Authors: Arthur J. Moss
Journal: JAMA (1969)

Long-term left atrial pacing was successfully accomplished in three patients by positioning permanently implanted pervenous pacemaker catheters in the proximal portion of the coronary vein. Left atrial stimulation was documented by the configuration of the P waves on the electrocardiogram—the P waves were inverted in leads I and V<sub>6</sub>and upright in V<sub>1</sub>. Roentgenograms of the chest revealed that the pacemaker electrodes were located inferiorly and posteriorly to the left atrium. In one patient, angiocardiography was used to document the position of the catheter in the coronary vein. One patient died of causes unrelated to the pacemaker one month after implantation, and the catheter tip was located in the coronary vein which was not thrombosed. The other two patients are doing well 13 and 18 months, respectively, after pacemaker placement, and consistent and stable atrial pacing has continued throughout this period of time.
A Covenant Between Physician and Patient
Authors: K. DANNER CLOUSER
Journal: Annals of Internal Medicine (1985)

A class of medical school seniors desired more than the traditional graduation ceremony. They planned and presented a "baccalaureate service" to give voice to deeply felt concerns. A part of this service was a covenant in the form of a responsive reading between the new physicians and the public. The covenant, written for the occasion, encompasses mutual understanding and agreement between physician and patient, thereby avoiding pitfalls and anachronisms associated with traditional oaths and codes.
BOLIVIAN HEMORRHAGIC FEVER
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights from Recent Cancer Literature
Journal: Cancer Research (2016)

BCL2-Dependence in Acute Myelogenous LeukemiaKonopleva and colleagues present results of a phase 2 single arm study evaluating venetoclax, an oral BCL-2 inhibitor, in patients with relapsed/refractory acute myelogenous leukemia.Objective response rate was 19% (6/32), with an additional 19% of patients showing partial responses.Notably, 27% of patients with a BCL-2-family-sensitive protein index, defined as 35% of tumor cells expressing BCL-2 and <40% of tumor cells expressing BCL-X L , underwent longer duration of therapy with venetoclax.BH3 profiling identified samples with the most BCL-2 dependence and sensitivity to BCL-2 inhibition.Unlike patients with chronic lymphocytic leukemia, dependence on BCL-2 was not sufficient for durable clinical benefit.The objective activity with a well-tolerated single oral agent was notable in a disease notorious for responding only to dose-intensive chemotherapy.Additional studies will need to refine biomarkers to identify patients who may benefit from BCL-2 inhibition.(Image from cited article courtesy of the publisher.
Extramedullary Hematopoiesis Presenting as a Pelvic Mass in a Patient With β-Thalassemia Intermedia
Authors: Kristy L. Newton
Journal: JAMA (1983)

PATIENTS with β-thalassemia intermedia often have radiological bone and soft-tissue findings of extra-medullary hematopoiesis. Most often described in the thorax and cranium, these soft-tissue masses may be found at any site along the vertebral column. <h3>Report of a Case</h3> During a yearly pelvic examination, a 36-year-old black woman was noted to have a pelvic mass. At age 12, a diagnosis of β-thalassemia major (homozygous) intermedia was made. Examination disclosed that the liver was palpable 3 cm below the right costal margin and an enlarged spleen was detected 7 cm below the left costal margin. The uterus was of normal size and displaced anteriorly; the adnexae were normal. A 6-cm cul-de-sac mass was described as firm, immobile, nontender, and smooth. The superior border could not be delineated. The hematocrit reading was 25.5%, and the WBC count was 5,600/cu mm, with a normal differential cell count. Erythrocyte indexes were microcytic and hypochromic.
Chondromalacia patellae.
Authors: Larry W. Moreland Dr.
Journal: BMJ (1981)

Chondromalacia patellae is a relatively common condition affecting adolescents or young adults, involving the articular cartilage of the patella and opposing femoral condyles. Etiological factors, clinical features and radiographic signs of this condition are discussed. A conservative treatment approach is put forth emphasizing rehabilitative exercise, bracing and spinal manipulation.
Epidemiology in Country Practice
Authors: William N. Pickles
Journal: New England Journal of Medicine (1948)

AS I studied the long list of my illustrious predecessors who have presented the Cutter Lecture on Preventive Medicine I was truly grateful to the pious founder, that modest and yet forceful character, Dr. John Clarence Cutter, for the opportunity to visit this great country, to receive so many kindnesses from so many people and to find a truly New World opened to us on this side of the Atlantic. But what had I to offer in comparison with such eminent men? For I come to speak about very simple things, everyday happenings and elementary deductions drawn from them such . . .
The Anatomy of the Nervous System from the Standpoint of Development and Function.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal