tbuckley/cabot-search huggingface dataset:
Changing climate seen in efforts to tell public about smoking, health
Authors: C. Marwick
Journal: JAMA (1984)

A few days ago, President Reagan signed into law the Smoking Prevention and Health Education Act. "This is an indication that those who are concerned about smoking and health are gaining strength. This bill could never have passed Congress three years ago," declares Matthew L. Myers, JD, a Washington, DC, lawyer and director of the Coalition on Smoking or Health. An even more realistic assessment of the bill's passage comes from David N. Sundwall, MD, a professional staff member of the Senate Committee on Labor and Human Resources chaired by Sen Orrin G. Hatch of Utah, one of the bill's sponsors. "It's astonishing it got through at all," Sundwall says. The legislation represents a "national public education effort designed to improve our awareness about what the surgeon general has said is the No. 1 preventable cause of death—cigarette smoking," Sen Hatch said during the final debate on the bill. "This
Boards of Examiners in the Basic Sciences
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trastuzumab-related cardiotoxicity among older breast cancer patients.
Authors: Mariana Chavez-Mac Gregor, Ning Zhang, Thomas A. Buchholz, Yufeng Zhang, Jiangong Niu, Linda S. Elting, Gabriel N. Hortobagyi, Sharon Hermes Giordano
Journal: Journal of Clinical Oncology (2012)

600 Background: The use of trastuzumab in the adjuvant setting is associated with reduction in mortality and recurrence. Although trastuzumab is extremely well tolerated, its use is associated with congestive heart failure (CHF). The incidence of this complication in the general population remains largely unknown, especially in older patients. In this study we evaluated the rates and risk factors associated with trastuzumab-related CHF in a large cohort of older breast cancer patients. Methods: Breast cancer patients ≥ 66 years with full Medicare coverage, diagnosed with stage I-III breast cancer between 2005-2007, and treated with chemotherapy were identified in the Surveillance, Epidemiology and End Results-Medicare (SEER-Medicare) database. Chemotherapy and trastuzumab use, comorbidities and CHF were identified using ICD-9 and HCPCS codes. Analyses included descriptive statistics, Cox proportional hazard model using trastuzumab as a time-dependent variable and logistic regression. Results: A total of 3,983 patients were included, 847 (21.7%) of them received trastuzumab, median age of the entire cohort was 71 years old. Among trastuzumab users the rate of CHF was 28.6% compared to 18.1% in non-trastuzumab users (p&lt;.0001). After adjusting for demographic and clinical characteristics, comorbidities, and type of chemotherapy used, trastuzumab users were more likely to develop CHF than non-trastuzumab users (HR 1.74; 95% CI 1.47-2.06). Among trastuzumab users, older age did not further increase the risk, however history of coronary artery disease (OR 2.23; 95%CI 1.56-3.19), heart valve disease (OR 1.41; 95%CI 1.41-2.88) and emphysema -as a proxy for smoking- (OR 2.03; 95% CI 1.13-3.63) significantly increased the risk of CHF. There was a trend for increased risk of CHF associated with anthracycline use (OR 1.36; 95% CI 0.93-2.00). Conclusions: In this large cohort of older breast cancer patients, the risk of CHF among trastuzumab users was 1.74 times higher than non-trastuzumab users, which is higher than what has been reported in younger clinical trial participants. Among older breast cancer patients treated with trastuzumab, cardiac comorbidities and emphysema may identify high risk patients.
Generally speaking
Authors: N. J. Pisacano
Journal: JAMA (1970)

I would like to set out with a few simple but sweeping<i>generalizations</i>concerning the impact of medical education on the practice of medicine. These<i>generalizations</i>are also,<i>in general</i>, negative. I make no apology for being negative nor do I subscribe to the sophistry of the academic world which implies that<i>generalizations</i>are necessarily false and lead to illogical conclusions. My first<i>generalization</i>, then, is (1) that medical schools have contributed little toward the improvement of the<i>practice</i>of medicine; (2) that, in fact, medical educators have very little understanding of what comprehensive medicine truly is; (3) that the rise of the newest approved specialty, family practice, after many abortive attempts at approval, owes little to medical educators for its eventual success in attaining approval on Feb 8, 1969; and (4) that, even in the light of this recent surge of interest in family practice, many deans and/or their
Gynäkologische Strahleneffekte und eine merkwürdige Alopecie.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. II. Recommendations
Authors: Michael L. Cheatham, Manu L. N. G. Malbrain, Andrew Kirkpatrick, Michael Sugrue, Michael Parr, Jan De Waele, Zsolt Balogh, Ari Leppäniemi, Claudia Olvera, Rao Ivatury, Scott D’Amours, Julia Wendon, Ken Hillman, Alexander Wilmer
Journal: Intensive Care Medicine (2007)
Exophthalmic Goitre. A Lecture Delivered at the Northeast London Post-Graduate College, April 27, 1921.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diesel Engine Exhaust and Lung Cancer: An Unproven Association
Authors: Joshua E. Muscat, Ernst L. Wynder
Journal: Environmental Health Perspectives (1995)

The risk of lung cancer associated with diesel exhaust has been calculated from 14 case-control or cohort studies. We evaluated the findings from these studies to determine whether there is sufficient evidence to implicate diesel exhaust as a human lung carcinogen. Four studies found increased risks associated with long-term exposure, although two of the four studies were based on the same cohort of railroad workers. Six studies were inconclusive due to missing information on smoking habits, internal inconsistencies, or inadequate characterization of diesel exposure. Four studies found no statistically significant associations. It can be concluded that short-term exposure to diesel engine exhaust (< 20 years) does not have a causative role in human lung cancer. There is statistical but not causal evidence that long-term exposure to diesel exhaust (> 20 years) increases the risk of lung cancer for locomotive engineers, brakemen, and diesel engine mechanics. There is inconsistent evidence on the effects of long-term exposure to diesel exhaust in the trucking industry. There is no evidence for a joint effect of diesel exhaust and cigarette smoking on lung cancer risk. Using common criteria for determining causal associations, the epidemiologic evidence is insufficient to establish diesel engine exhaust as a human lung carcinogen.
I'm OK: therapy by advertised inaccurate assertion
Authors: M. E. Allen
Journal: JAMA (1986)

<h3>To the Editor.—</h3> Occasionally, in this high-tech world, simple and imaginative therapies can emerge. As a case in point, a woman was recently referred to me for management of what was presumed to be exercise-induced asthma. She wanted to continue her jogging, but the intensity of her wheezing was disturbing. However, on closer examination, her findings were hardly those of asthma but rather those of some other intense stridor originating not from her chest but from the left side of her neck. The scar from some previous childhood thyroid surgery provided the clue. Subsequent normal pulmonary function test results and a close look at her paralyzed left vocal cord served to rule out any associated disease. Closer questioning revealed that she was not dyspneic with exertion, but to most other passing joggers she appeared to be at her last gasp. It was impossible for her to jog casually through the
Omissions and Incorrect Units of Measure.
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
measles immunization
Authors: Phil Gunby
Journal: JAMA (1978)

Young people grow weary of hearing that they hold the key to the future. But, for the future government goal of eliminating indigenous measles by Oct 1,1982, immunization of adolescents and young adults indeed may be the key. An increasing proportion of the rubeola reported in this country is among the junior-high to young-adult group. Until recently this particular pattern of measles transmission escaped the attention of most epidemiologists. Before the vaccine came into use 15 years ago, 90% of cases of measles occurred in children under the age of 10. Now, according to a report given by A. David Brandling-Bennett, MD, at the American Public Health Association (APHA) meeting in Los Angeles, 60% of reported cases involve persons<i>over</i>10 years of age. Looking at it another way, officials at the Center for Disease Control (CDC), Atlanta, where Brandling-Bennett is chief of the Surveillance and Assessment Branch, report there
Gynecology
Authors: H. G. McQuarrie
Journal: JAMA (1979)

<h3>Endoscopy</h3> Historically, the endoscopic inspection of the body cavities, particularly cystoscopy, dates from the turn of the century. Abdominal cystoscopy by Trendelenburg positioning and gaseous distension was described in 1911, and gradual improvement continued until about 20 years ago, when culdoscopy and laparoscopy came into wide use with the perfection of techniques and instrumentation. Cold illumination opened new areas to direct inspection, and light conducted along quartz rods and flexible fiberglass guides made possible the design of equipment with great diagnostic and therapeutic potential. Gynecologists have long been aware of the limitations of clinical pelvic evaluation using speculums and vaginal and abdominal palpation. Endoscopy offers advantages of magnified inspection, biopsy, and aspiration for bacterial and cytological investigation.<sup>1</sup>Limited operations can be done such as sterilization by division or coagulation of the uterine tubes, lysis of pelvic adhesions, removal of a displaced intrauterine contraceptive device, and, recently, recovery of viable
The Study of Instinct
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ARTHRO-NEURALGIA.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Legionnaires' disease acquired within the homes of two patients. Link to the home water supply
Authors: J. E. Stout
Journal: JAMA (1987)

Two patients with sporadic community-acquired legionnaires' disease are described.<i>Legionella pneumophila</i>was isolated from sputum specimens, and seroconversion of antibody titers was demonstrated for both patients.<i>Legionella pneumophila</i>was also recovered from the residential water supply of both patients. In each case, the serogroup of the environmental organism matched that of the infecting organism. In one patient, serogroup 3 was isolated—a rare cause of legionnaires' disease, and in the second case, monoclonal antibody testing confirmed that the serogroup 1 organisms isolated from sputum and residential water supply samples were identical. The incubation period of legionnaires' disease is presumed to be up to two weeks. Because of medical problems, both patients had been confined to their homes for the entire two weeks before the onset of symptoms. This is the first report that links acquisition of community-acquired legionnaires' disease to contaminated water supplies within the homes of susceptible patients. (<i>JAMA</i>1987;257:1215-1217)
Are we training too many subspecialists?
Authors: Leonard Sax
Journal: JAMA (1988)

<h3>To the Editor.</h3> —Schwartz et al<sup>1</sup>ask: Are we training too many medical subspecialists? Most of their article is devoted to demonstrating that many small cities and towns do not have their own hematologist, endocrinologist, or pulmonologist. The authors draw a startling conclusion from this unremarkable finding: they believe that there is, and will continue to be, a significant shortage of medical subspecialists. This conclusion makes sense only if you believe, as they do, that every small town<i>needs</i>every kind of medical subspecialist: "We believe that cities with a population over 50 000 easily warrant the presence of at least one board-certified subspecialist in each field (including rheumatology, nephrology, endocrinology, and so on)." They give two grounds for this questionable belief. First, "cities with a population of 50 000 to 125 000 have an average of... 343 occupied beds" and, second, "subspecialists in these cities will also treat
Hemodynamic Performance at Rest and During Exercise After Aortic Valve Replacement: Comparison of Pulmonary Autografts Versus Aortic Homografts
Authors: Isabelle Laforest, Jean G. Dumesnil, Martin Briand, Paul C. Cartier, Philippe Pibarot
Journal: Circulation (2002)

Background The Ross procedure and aortic homografts have both been shown to have superior hemodynamic performance after valve replacement, but there have been few comparisons. Methods Sequential Doppler echocardiograms were performed up to 5 years after aortic valve replacement in 132 patients with the Ross procedure and 111 patients with an aortic homograft (AH). Measurements included assessment of valvular regurgitation and calculations of valve effective orifice area (EOA) and mean transvalvular gradients; the same measurements were also performed at the level of the pulmonary homograft in the Ross patients as well as during maximum exercise in 20 Ross patients and 14 AH patients. Results Aortic valve hemodynamics were stable during follow-up for both procedures and values at 1 year showed larger indexed EOAs (1.77±0.45 versus 1.42±0.35 cm 2 /m 2 , P &lt;0.001) and lower gradients (2±3 versus 4±3 mm Hg) for the Ross procedure; similar findings were also observed during exercise (1.99±0.44 versus 1.36±0.39 cm 2 /m 2 , P &lt;0.001 and 7±3 versus 17±11 mm Hg). Prevalence and severity of aortic regurgitation were low in both groups, although 4 patients (1 Ross, 3 AH) underwent a second operation for this reason. Also, various degrees of pulmonary homograft stenosis were found in 20% of Ross patients, 4 of which underwent a second operation. Conclusion Both procedures provide continued excellent hemodynamics of the aortic valve. The Ross procedure has a slight advantage, but this is somewhat counterbalanced by the deterioration of the pulmonary homograft in up to 20% of patients. Further studies aimed at clarifying longer-term outcomes as well as preventing pulmonary homograft stenosis with the Ross operation are clearly needed.
THE NAVAL MEDICAL CORPS.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transfusion, Milwaukee
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal