tbuckley/cabot-search huggingface dataset:
Heterogeneity, crosstalk, and targeting of cancer-associated fibroblasts in cholangiocarcinoma
Authors: Paula Cantallops Vilà, Aashreya Ravichandra, Aloña Agirre Lizaso, Maria J. Perugorria, Silvia Affò
Journal: Hepatology (2023)

Cholangiocarcinoma (CCA) comprises diverse tumors of the biliary tree and is characterized by late diagnosis, short-term survival, and chemoresistance. CCAs are mainly classified according to their anatomical location and include diverse molecular subclasses harboring inter-tumoral and intratumoral heterogeneity. Besides the tumor cell component, CCA is also characterized by a complex and dynamic tumor microenvironment where tumor cells and stromal cells crosstalk in an intricate network of interactions. Cancer-associated fibroblasts, one of the most abundant cell types in the tumor stroma of CCA, are actively involved in cholangiocarcinogenesis by participating in multiple aspects of the disease including extracellular matrix remodeling, immunomodulation, neo-angiogenesis, and metastasis. Despite their overall tumor-promoting role, recent evidence indicates the presence of transcriptional and functional heterogeneous CAF subtypes with tumor-promoting and tumor-restricting properties. To elucidate the complexity and potentials of cancer-associated fibroblasts as therapeutic targets in CCA, this review will discuss the origin of cancer-associated fibroblasts, their heterogeneity, crosstalk, and role during tumorigenesis, providing an overall picture of the present and future perspectives toward cancer-associated fibroblasts targeting CCA.
The Optimal Treatment for Acute Appendicitis—Is Age Just a Number?
Authors: George Q. Zhang, Gentian Kristo, Jason S. Gold
Journal: JAMA Surgery (2023)

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How puzzling is the social artifact puzzle?
Authors: Tom Ziemke, Sam Thellman
Journal: Behavioral and Brain Sciences (2023)

Abstract In this commentary we would like to question (a) Clark and Fischer's characterization of the “social artifact puzzle” – which we consider less puzzling than the authors, and (b) their account of social robots as depictions involving three physical scenes – which to us seems unnecessarily complex. We contrast the authors' model with a more parsimonious account based on attributions.
Of children and social robots
Authors: Elizabeth J. Goldman, Anna-Elisabeth Baumann, Diane Poulin-Dubois
Journal: Behavioral and Brain Sciences (2023)

Abstract In the target article, Clark and Fischer argue that little is known about children's perceptions of social robots. By reviewing the existing literature we demonstrate that infants and young children interact with robots in the same ways they do with other social agents. Importantly, we conclude children's understanding that robots are artifacts (e.g., not alive) develops gradually during the preschool years.
Errors in Author Names and Affiliation
Authors: François Carrier, Alexis Turgeon
Journal: JAMA Surgery (2023)

Julie Hallet, MD, MSc; Rinku Sutradhar, PhD; Angela Jerath, MD, MSc; Pablo Perez d’Empaire, MD; François M. Carrier, MD, MSc; Alexis F. Turgeon, MD, MSc; Daniel I. McIsaac, MD, MPH; Chris Idestrup, MD, MSc; Gianni Lorello, MD, MSc; Alana Flexman, MD; Biniam Kidane, MD, MSc; Yosuf Kaliwal, MPH; Wing C. Chan, MPH; Victoria Barabash, MSc; Natalie Coburn, MD, MPH; Antoine Eskander, MD, ScM
Association of Ambient Temperature with Mortality in Resident and Multiethnic Transient Populations in a Desert Climate, 2006–2014
Authors: Saber Yezli, Altaf H. Khan, Yara M. Yassin, Anas A. Khan, Badriah M. Alotaibi, Abderrezak Bouchama
Journal: Environmental Health Perspectives (2023)

Although the association between ambient temperature and mortality in local populations is evident, this relationship remains unclear in transient populations (e.g., due to immigration, mass gatherings, or displacement). The holy city of Mecca annually shelters two populations comprising its residents and the transitory Hajj pilgrims (>2 million people from >180 countries). Both live side by side in a hot desert climate, rendering the development of evidence-based heat-protective measures challenging.We aimed to characterize the ambient temperature-mortality relationship and burden for the Mecca resident and Hajj transient populations, which have distinct levels of adaptation to ambient temperature.We analyzed daily air temperature and mortality data for Mecca residents and pilgrims over nine Hajj seasons between 2006 and 2014, using a fitted standard time-series Poisson model. We characterized the temperature-mortality relationship with a distributed lag nonlinear model with 10 d of lag. We determined the minimum mortality temperature (MMT) and attributable deaths for heat and cold for the two populations.The median average daily temperature during the Hajj seasons was 30°C (19°C-37°C). There were 8,543 and 10,457 nonaccidental deaths reported during the study period among Mecca residents and pilgrims, respectively. The MMT was 2.5°C lower for pilgrims in comparison with the MMT for Mecca residents (23.5°C vs. 26.0°C). The temperature-mortality relationship shape varied from inverted J to U shape for the Mecca and pilgrim populations, respectively. Neither hot nor cold temperatures had a statistically significant association with mortality in Mecca residents. In contrast, for pilgrims, elevated temperatures were associated with significantly high attributable mortality of 70.8% [95% confidence interval (CI): 62.8, 76.0]. The effect of heat on pilgrims was immediate and sustained.Our findings indicate that pilgrims and Mecca residents exposed to the same hot environmental conditions exhibited distinct health outcomes. This conclusion suggests that a precision public health approach may be warranted to protect against high environmental temperature during mass gatherings of diverse populations. https://doi.org/10.1289/EHP9838.
Ductal delivery of extracellular vesicles promote the recovery from salivary gland inflammation
Authors: Donghyun Kim, Kyung Min Lim, Jae-Min Cho, Hyo Jin Park, Seungyeon Hwang, Ahmed Abdal Dayem, Ye Jin Jeong, Yeokyung Shin, Yongpyo Hong, Kwonwoo Song, Ssang-Goo Cho, Jae-Yol Lim
Journal: Journal of Controlled Release (2023)
Major Adverse Cardiovascular Events After Intracerebral Hemorrhage—It’s All About Location, Location, Location
Authors: Marialaura Simonetto, Santosh B. Murthy
Journal: JAMA Network Open (2023)

Nils Jensen Boe, MD; Stine Munk Hald, PhD; Mie Micheelsen Jensen, MD; Line Marie Buch Kristensen, MD; Jonas Asgaard Bojsen, MD; Mohammad Talal Elhakim, MD; Anne Clausen, MSc; Sören Möller, PhD; Jesper Hallas, DMSc; Luis Alberto García Rodríguez, MD; Magdy Selim, PhD; Larry B. Goldstein, MD; Rustam Al-Shahi Salman, PhD; David Gaist, PhD
4D Printed Programmable Shape‐Morphing Hydrogels as Intraoperative Self‐Folding Nerve Conduits for Sutureless Neurorrhaphy
Authors: Akshat Joshi, Saswat Choudhury, Vageesh Singh Baghel, Souvik Ghosh, Sumeet Gupta, Debrupa Lahiri, G. K. Ananthasuresh, Kaushik Chatterjee
Journal: Advanced Healthcare Materials (2023)

There are only a few reports of implantable 4D printed biomaterials, most of which exhibit slow deformations rendering them unsuitable for in situ surgical deployment. In this study, a hydrogel system is engineered with defined swelling behaviors, which demonstrated excellent printability in extrusion-based 3D printing and programmed shape deformations post-printing. Shape deformations of the spatially patterned hydrogels with defined infill angles are computationally predicted for a variety of 3D printed structures, which are subsequently validated experimentally. The gels are coated with gelatin-rich nanofibers to augment cell growth. 3D-printed hydrogel sheets with pre-programmed infill patterns rapidly self-rolled into tubes in vivo to serve as nerve-guiding conduits for repairing sciatic nerve defects in a rat model. These 4D-printed hydrogels minimized the complexity of surgeries by tightly clamping the resected ends of the nerves to assist in the healing of peripheral nerve damage, as revealed by histological evaluation and functional assessments for up to 45 days. This work demonstrates that 3D-printed hydrogels can be designed for programmed shape changes by swelling in vivo to yield 4D-printed tissue constructs for the repair of peripheral nerve damage with the potential to be extended in other areas of regenerative medicine.
Accelerating Practice Change in the Emergency Department
Authors: Scott G. Weiner, Jason A. Hoppe
Journal: JAMA Network Open (2023)

Gail D'Onofrio, MD, MS; E. Jennifer Edelman, MD, MHS; Kathryn F. Hawk, MD, MHS; Marek C. Chawarski, PhD; Michael V. Pantalon, PhD; Patricia H. Owens, MS; Shara H. Martel, MPH, MS; Richard Rothman, MD, PhD; Mustapha Saheed, MD; Robert P. Schwartz, MD; Ethan Cowan, MD; Lynne Richardson, MD; Edwin Salsitz, MD; Michael S. Lyons, MD, MPH; Caroline Freiermuth, MD; Christine Wilder, MD; Lauren Whiteside, MD, MPH; Judith I. Tsui, MD, MPH; Jared W. Klein, MD, MPH; Edouard Coupet, MD, MHS; Patrick G. O'Connor, MD, MPH; Abigail G. Matthews, PhD; Sean M. Murphy, PhD; Kristen Huntley, PhD; David A. Fiellin, MD
Long-Term Exposure to Air Pollution and COVID-19 Vaccine Antibody Response in a General Population Cohort (COVICAT Study, Catalonia)
Authors: Manolis Kogevinas, Marianna Karachaliou, Ana Espinosa, Ruth Aguilar, Gemma Castaño-Vinyals, Judith Garcia-Aymerich, Anna Carreras, Beatriz Cortés, Vanessa Pleguezuelos, Kyriaki Papantoniou, Rocío Rubio, Alfons Jiménez, Marta Vidal, Pau Serra, Daniel Parras, Pere Santamaría, Luis Izquierdo, Marta Cirach, Mark Nieuwenhuijsen, Payam Dadvand, Kurt Straif, Gemma Moncunill, Rafael de Cid, Carlota Dobaño, Cathryn Tonne
Journal: Environmental Health Perspectives (2023)

BACKGROUND: Ambient air pollution has been associated with COVID-19 disease severity and antibody response induced by infection.OBJECTIVES: We examined the association between long-term exposure to air pollution and vaccine-induced antibody response.METHODS: This study was nested in an ongoing population-based cohort, COVICAT, the GCAT-Genomes for Life cohort, in Catalonia, Spain, with multiple follow-ups.We drew blood samples in 2021 from 1,090 participants of 2,404 who provided samples in 2020, and we included 927 participants in this analysis.We measured immunoglobulin M (IgM), IgG, and IgA antibodies against five viral-target antigens, including receptor-binding domain (RBD), spike-protein (S), and segment spike-protein (S2) triggered by vaccines available in Spain.We estimated prepandemic (2018-2019) exposure to fine particulate matter [PM ≤2:5 lm in aerodynamic diameter (PM 2:5 )], nitrogen dioxide (NO 2 ), black carbon (BC), and ozone (O 3 ) using Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE) models.We adjusted estimates for individual-and area-level covariates, time since vaccination, and vaccine doses and type and stratified by infection status.We used generalized additive models to explore the relationship between air pollution and antibodies according to days since vaccination.RESULTS: Among vaccinated persons not infected by SARS-CoV-2 (n = 632), higher prepandemic air pollution levels were associated with a lower vaccine antibody response for IgM (1 month post vaccination) and IgG.Percentage change in geometric mean IgG levels per interquartile range of PM 2:5 (1:7 lg=m 3 ) were -8:1 (95% CI: -15:9, 0.4) for RBD, -9:9 (-16:2, -3:1) for S, and -8:4 (-13:5, -3:0) for S2.We observed a similar pattern for NO 2 and BC and an inverse pattern for O 3 .Differences in IgG levels by air pollution levels persisted with time since vaccination.We did not observe an association of air pollution with vaccine antibody response among participants with prior infection (n = 295).DISCUSSION: Exposure to air pollution was associated with lower COVID-19 vaccine antibody response.The implications of this association on the risk of breakthrough infections require further investigation.
The second-order problem of other minds
Authors: Ori Friedman, Arber Tasimi
Journal: Behavioral and Brain Sciences (2023)

Abstract The target article proposes that people perceive social robots as depictions rather than as genuine social agents. We suggest that people might instead view social robots as social agents, albeit agents with more restricted capacities and moral rights than humans. We discuss why social robots, unlike other kinds of depictions, present a special challenge for testing the depiction hypothesis.
Virtual <i>and</i> real: Symbolic and natural experiences with social robots
Authors: Byron Reeves
Journal: Behavioral and Brain Sciences (2023)

Abstract Interactions with social robots are symbolic experiences guided by the pretense that robots depict real people. But they can also be natural experiences that are direct, automatic, and independent of any thoughtful mapping between what is real and depicted. Both experiences are important, both may apply within the same interaction, and they may vary within a person over time.
Trait attribution explains human–robot interactions
Authors: Yochanan E Bigman, Nicholas Surdel, Melissa J Ferguson
Journal: Behavioral and Brain Sciences (2023)

Abstract Clark and Fischer (C&amp;F) claim that trait attribution has major limitations in explaining human–robot interactions. We argue that the trait attribution approach can explain the three issues posited by C&amp;F. We also argue that the trait attribution approach is parsimonious, as it assumes that the same mechanisms of social cognition apply to human–robot interaction.
How cultural framing can bias our beliefs about robots and artificial intelligence
Authors: Jeff M Stibel, H Clark Barrett
Journal: Behavioral and Brain Sciences (2023)

Abstract Clark and Fischer argue that humans treat social artifacts as depictions. In contrast, theories of distributed cognition suggest that there is no clear line separating artifacts from agents, and artifacts can possess agency. The difference is likely a result of cultural framing. As technology and artificial intelligence grow more sophisticated, the distinction between depiction and agency will blur.
Error in Table 1 and Results
Journal: JAMA Network Open (2023)

Letter titled "Incidence of Chronic Spontaneous Urticaria Following Receipt of the COVID-19 Vaccine Booster in Switzerland," 1 published February 1, 2023, the number of participants in the CSU-Swiss cohort who received the Moderna vaccine was incorrectly written in the Results and Table 1 as 77 (94%); the correct number is 727 (93%).This article has been corrected. 1
Urinary Phthalate Metabolites and Slow Walking Speed in the Korean Elderly Environmental Panel II Study
Authors: Jeonggyo Yoon, Esther García-Esquinas, Junghoon Kim, Jung Hyun Kwak, Hongsoo Kim, Sungroul Kim, Kyoung-Nam Kim, Yun-Chul Hong, Yoon-Hyeong Choi
Journal: Environmental Health Perspectives (2023)

Background: Previous epidemiological studies have suggested that phthalate exposure may contribute to neurocognitive and neurobehavioral disorders and decreased muscle strength and bone mass, all of which may be associated with reduced physical performance. Walking speed is a reliable assessment tool for measuring physical performance in adults age 60 y and older. Objective: We investigated associations between urinary phthalate metabolites and slowness of walking speed in community-dwelling adults ages 60–98 y. Methods: We analyzed 1,190 older adults [range, 60–98 y of age; mean±standard deviation (SD) , 74.81±5.99] from the Korean Elderly Environmental Panel II study and measured repeatedly up to three times between 2012 and 2014. Phthalate exposure was estimated using the following phthalate metabolites in urine samples: mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-n-butyl phthalate (MnBP), mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), and mono-benzyl phthalate (MBzP). Slowness was defined as a walking speed of <1.0meter/second. We used logistic and linear regression models to evaluate the association between each urinary phthalate metabolite and slowness or walking-speed change. We also used Bayesian kernel machine regression (BKMR) to examine overall mixture effects on walking speed. Results: At enrollment, MBzP levels were associated with an increased odds of slowness [odds ratio (OR) per doubling increase: 1.15, 95% confidence interval (CI): 1.02, 1.30; OR for the highest vs. lowest quartile: 2.20 (95% CI: 1.12, 4.35) with p-trend across quartiles=0.031]. In longitudinal analyses, MEHHP levels showed an increased risk of slowness [OR per doubling increase: 1.15 (95% CI: 1.02, 1.29), OR for the highest vs. lowest quartile: 1.47 (95% CI: 1.04, 2.06), p- trend=0.035]; whereas those with higher MnBP showed a reduced risk of slowness [OR per doubling increase: 0.84 (95% CI: 0.74, 0.96), OR in the highest (vs. lowest) quartile: 0.64 (95% CI: 0.47, 0.87), p-trend=0.006]. For linear regression models, MBzP quartiles were associated with slower walking speed (p-trend=0.048) at enrollment, whereas MEHHP quartiles were associated with slower walking speed, and MnBP quartiles were associated with faster walking speed in longitudinal analysis (p-trend=0.026 and <0.001, respectively). Further, the BKMR analysis revealed negative overall trends between the phthalate metabolite mixtures and walking speed and DEHP group (MEHHP, MEOHP, and MECPP) had the main effect of the overall mixture. Discussion: Urinary concentrations of prevalent phthalates exhibited significant associations with slow walking speed in adults ages 60–98 y. https://doi.org/10.1289/EHP10549
Complications and treatment errors in peri‐implant hard tissue management
Authors: Istvan Urban, Ignacio Sanz‐Sánchez, Alberto Monje, Eduardo Montero
Journal: Periodontology 2000 (2023)

Abstract Bone augmentation procedures aim to regenerate the deficient alveolar ridge to properly place dental implants that are completely surrounded by bone. However, these are invasive and technically demanding surgeries that are not free of either complications or treatment errors. Careful patient selection and preparation is a mandatory process to reduce the rate of complications in bone regeneration procedures, irrespective of the technique used. It is important to assess the cost benefit of the intervention and to evaluate the potential impact on the patient's quality of life, especially in the elderly and medically compromised patients. Most common postoperative complications are wound dehiscences, which may be reduced, at least partially, by proper knowledge of the surgical technique and the craniofacial anatomy. Other complications that may appear are postoperative infections or nerve injuries. The aim of this narrative review is to summarize the best available scientific evidence on the incidence of complications, as well as the ideal strategies for their prevention and management. Depending on the severity of the complication, treatment approaches may vary and can include drug prescription or even surgical re‐entries to remove exposed barrier membranes or contaminated bone grafts. Adequate prevention and proper management of complications associated with bone augmentation interventions are a requirement for clinicians carrying out these demanding procedures. A series of cases illustrating proper management of complications in different clinical scenarios is presented.
Letter to the editor: Targeted decrease of portal hepatic pressure gradient immediately after TIPS improves ascites control and prognosis
Authors: Xinxing Tantai, Jinhai Wang, Shejiao Dai
Journal: Hepatology (2023)

Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, PR China Correspondence Shejiao Dai, Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, PR China. E-mail: [email protected]
“Who's there?”: Depicting identity in interaction
Authors: Patrick G. T. Healey, Christine Howes, Ruth Kempson, Gregory J. Mills, Matthew Purver, Eleni Gregoromichelaki, Arash Eshghi, Julian Hough
Journal: Behavioral and Brain Sciences (2023)

Social robots have limited social competences. This leads us to view them as depictions of social agents rather than actual social agents. However, people also have limited social competences. We argue that all social interaction involves the depiction of social roles and that they originate in, and are defined by, their function in accounting for failures of social competence.
Cues trigger depiction schemas for robots, as they do for human identities
Authors: Eliott K Doyle, Sara D Hodges
Journal: Behavioral and Brain Sciences (2023)

Abstract Clark and Fischer's three levels of depiction of social robots can be conceptualized as cognitive schemas. When interacting with social robots, humans shift between schemas similarly to how they shift between identity category schemas when interacting with other humans. Perception of mind, context cues, and individual differences underlie perceptions of which level of depiction is most situationally relevant.
Vaccination of TLR7/8 Agonist‐Conjugated Antigen Nanoparticles for Cancer Immunotherapy
Authors: Ning Wang, Guiqiang Zhang, Peiyu Zhang, Kaijie Zhao, Yuan Tian, Jiwei Cui
Journal: Advanced Healthcare Materials (2023)

Abstract Nanovaccine‐based immunotherapy can initiate strong immune responses and establish a long‐term immune memory to prevent tumor invasion and recurrence. Herein, the assembly of redox‐responsive antigen nanoparticles (NPs) conjugated with imidazoquinoline‐based TLR7/8 agonists for lymph node‐targeted immune activation is reported, which can potentiate tumor therapy and prevention. Antigen NPs are assembled via the templating of zeolitic imidazolate framework‐8 NPs to cross‐link ovalbumin with disulfide bonds, which enables the NPs with redox‐responsiveness for improved antigen cross‐presentation and dendritic cell activation. The formulated nanovaccines promote the lymphatic co‐delivery of antigens and agonists, which can trigger immune responses of cytotoxic T lymphocytes and strong immunological memory. Notably, nanovaccines demonstrate their superiority for tumor prevention owing to the elicited robust antitumor immunity. The reported strategy provides a rational design of nanovaccines for enhanced cancer immunotherapy.