tbuckley/cabot-search huggingface dataset:
Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH-sensitive chemo-phototherapy
Authors: Xueqin Huang, Bingbing Sheng, Hemi Tian, Qiuxia Chen, Yingqi Yang, Brian Bui, Jiang Pi, Huaihong Cai, Shanze Chen, Jianglin Zhang, Wei Chen, Haibo Zhou, Pinghua Sun
Journal: Acta Pharmaceutica Sinica B (2022)

In situ and real-time monitoring of responsive drug release is critical for the assessment of pharmacodynamics in chemotherapy. In this study, a novel pH-responsive nanosystem is proposed for real-time monitoring of drug release and chemo-phototherapy by surface-enhanced Raman spectroscopy (SERS). The Fe3O4@Au@Ag nanoparticles (NPs) deposited graphene oxide (GO) nanocomposites with a high SERS activity and stability are synthesized and labeled with a Raman reporter 4-mercaptophenylboronic acid (4-MPBA) to form SERS probes (GO-Fe3O4@Au@Ag-MPBA). Furthermore, doxorubicin (DOX) is attached to SERS probes through a pH-responsive linker boronic ester (GO-Fe3O4@Au@Ag-MPBA-DOX), accompanying the 4-MPBA signal change in SERS. After the entry into tumor, the breakage of boronic ester in the acidic environment gives rise to the release of DOX and the recovery of 4-MPBA SERS signal. Thus, the DOX dynamic release can be monitored by the real-time changes of 4-MPBA SERS spectra. Additionally, the strong T2 magnetic resonance (MR) signal and NIR photothermal transduction efficiency of the nanocomposites make it available for MR imaging and photothermal therapy (PTT). Altogether, this GO-Fe3O4@Au@Ag-MPBA-DOX can simultaneously fulfill the synergistic combination of cancer cell targeting, pH-sensitive drug release, SERS-traceable detection and MR imaging, endowing it great potential for SERS/MR imaging-guided efficient chemo-phototherapy on cancer treatment.
Table of Contents
Authors: Rupert Major, Paul Cockwell, Dorothea Nitsch, Navdeep Tangri, Stuart Shankland, Oliver Wessely, Letizia De Chiara, Yun Xia, Thimoteus Speer, Stefan Schunk, Julie Ingelfinger, Kathleen Gallant, Xin-Yuan Zheng, Atlas Khan, Krzysztof Kiryluk, Bryce Kiberd, Wai Lim, Eryn Dixon, Haojia Wu, Elizabeth Sulvarán-Guel, Juanru Guo, Benjamin Humphreys, Maciej Tomaszewski, Andrew Morris, Joanna Howson, Nora Franceschini, James Eales, Xiaoguang Xu, Sergey Dikalov, Tomasz Guzik, Stephen Harrap, Fadi Charchar Open, Xiaowen Chen, Huishi Tan, Jie Xu, Yuan Tian, Qian Yuan, Yangyang Zuo, Qiyan Chen, Xue Hong, Haiyan Fu, Fan Hou, Lili Zhou, Youhua Liu, Huiying Li, Xiaoli Zhao, Liyun Zheng, Xiukun Wang, Shuai Lin, Jiajia Shen, Hangjiang Ren, Yi Li, Qiang Qiu, Zhen Wang, Yosuke Nagai, Keiichiro Matoba, Yusuke Takeda, Hideji Yako, Tomoyo Akamine, Kensuke Sekiguchi, Yasushi Kanazawa, Tamotsu Yokota, Kazunori Sango, Daiji Kawanami, Kazunori Utsunomiya, Rimei Nishimura
Journal: Kidney International (2022)
Advisory Board and Contents
Authors: Gerard Dumancas, Destiny Harrison, Jonathan Rico, Pia Regina, Fatima Zamora, Aretha Liwag, Joselito Villaruz, Ma Luz, Vicenta Guanzon, Hans Francis, D Ferraris, Joseph Jalandoni, Webster Padernal, Bea Nestie, L Villareal, Ria Maculada, Mae Fernandez, Felix Villa, Romulo De Castro, Adekunle Bademosi, Adam Walker
Journal: Trends in Genetics (2022)
The genomic epidemiology of mcr-positive Salmonella enterica in clinical patients from 2014 to 2017 in Sichuan, China and global epidemiological features
Authors: Ruichao Li, Kai Peng, Weifeng Huang, Xinran Sun, Yulan Huang, Gaopeng Lei, Hong Lv, Zhiqiang Wang, Xiaorong Yang
Journal: Journal of Infection (2022)
Neutrophil extracellular traps contribute to liver damage and increase defective low-density neutrophils in alcohol-associated hepatitis
Authors: Yeonhee Cho, Terence Ndonyi Bukong, David Tornai, Mrigya Babuta, Ioannis S. Vlachos, Eleni Kanata, Donna Catalano, Gyongyi Szabo
Journal: Journal of Hepatology (2022)
Integrating temporal single-cell gene expression modalities for trajectory inference and disease prediction
Authors: Jolene S. Ranek, Natalie Stanley, Jeremy E. Purvis
Journal: Genome biology (2022)

Current methods for analyzing single-cell datasets have relied primarily on static gene expression measurements to characterize the molecular state of individual cells. However, capturing temporal changes in cell state is crucial for the interpretation of dynamic phenotypes such as the cell cycle, development, or disease progression. RNA velocity infers the direction and speed of transcriptional changes in individual cells, yet it is unclear how these temporal gene expression modalities may be leveraged for predictive modeling of cellular dynamics.
Robotic Intracellular Electrochemical Sensing for Adherent Cells
Authors: Weikang Hu, Yanmei Ma, Zhen Zhan, Danish Hussain, Chengzhi Hu
Journal: Cyborg and Bionic Systems (2022)

Nanopipette-based observation of intracellular biochemical processes is an important approach to revealing the intrinsic characteristics and heterogeneity of cells for better investigation of disease progression or early disease diagnosis. However, the manual operation needs a skilled operator and faces problems such as low throughput and poor reproducibility. This paper proposes an automated nanopipette-based microoperation system for cell detection, three-dimensional nonovershoot positioning of the nanopipette tip in proximity to the cell of interest, cell approaching and proximity detection between nanopipette tip and cell surface, and cell penetration and detection of the intracellular reactive oxygen species (ROS). A robust focus algorithm based on the number of cell contours was proposed for adherent cells, which have sharp peaks while retaining unimodality. The automated detection of adherent cells was evaluated on human umbilical cord vein endothelial cells (HUVEC) and NIH/3T3 cells, which provided an average of 95.65% true-positive rate (TPR) and 7.59% false-positive rate (FPR) for in-plane cell detection. The three-dimensional nonovershoot tip positioning of the nanopipette was achieved by template matching and evaluated under the interference of cells. Ion current feedback was employed for the proximity detection between the nanopipette tip and cell surface. Finally, cell penetration and electrochemical detection of ROS were demonstrated on human breast cancer cells and zebrafish embryo cells. This work provides a systematic approach for automated intracellular sensing for adherent cells, laying a solid foundation for high-throughput detection, diagnosis, and classification of different forms of biochemical reactions within single cells.
JAAD Case Reports Article List
Authors: Hai-Qing Wang, Chao Ji, Ting Gong, Dirk Elston, Celine Phong, Arash Babadjouni, Cristina Nguyen, Christina Kraus, Natasha Mesinkovska, Jonathan Ho, Alicia Mcnish, Letisha Mcdonald, Carol Burrell, Stephanie Smith-Matthews, Mary Joseph, Jihane Belcadi, Sara Ali, Ihssan Elouarith, Kaoutar Znati, Nadia Ismaili, Laila Benzekri, Karima Senouci, Marieme Meziane, Sarah Preis, Kathrin Schro ¨der, Tilo Biedermann, Alexander Zink, Tam Nguyen, Sarah Gabros, Sean Do, Akhil Friefeld, Stanley Gupta, Daniel Cole, Bo Wang, Douglas Fullen, Yolanda Helfrich, Molly Kuo, Naomi Briones, Masako Yamamoto, Yuriko Kawase, Hirohisa Kishi, Yuichiro Miyoshi, Hiroshi Mitsui, Shigeki Sekine, -Mutated Swyer, Ila Nimgaonkar, Marielle Jamgochian, David Milgraum, Amy Pappert, Sandy Milgraum, Emma Huard, Margot Raynal, Sylvie Fraitag, Emilie Angot, Solen Raymond, Vivien Hebert, Raphael Janela, Marc Grossman, Jia Ruan, Cynthia Magro, Selda Karaaslan, Robert Skrokov, Mary Valinotti, Neha Narayan, Christopher Richardson, Amy Zeglinski-Spinney, Carly Kirshen, Kathleen Spitz, Lena Chu, Leslie Lawley, Nicole Edmonds, Lydia Luu, Darren Guffey, Hisato Iriki, Noriko Umegaki-Arao, Risa Kakuta, Harumi Fujita, Satomi Aoki, Masayuki Amagai, Takashi Sasaki, Yasuo Hamamoto, Robert Nakayama, Akiharu Kubo, Erina Lie, Jaroslaw Jedrych, Ronald Sweren, Michelle Kerns, Vale ´rie Tremblay-Abel, Janie Bujold, Bernard Delisle, Ingrid Ganske, Alex Cappitelli, Olivia Langa, Michelle Min, Kathryn Torok, Fatma Dedeoglu, Ruth Vleugels, Cara Barber, Eingun Song, Denise Tsang, Po Tang, Choon Oh, Yen Luu, David Brooks, Anand Kimmis, Garth Rajpara, Laurence De Montjoye, Anne Herman, Marie Baeck, Evelyn Ilori, Shauna Campbell, Timothy Smile, Lanae Keller, Nikhil Joshi, Neil Woody, Shlomo Koyfman, Alexis Strahan, Rowanne Ali, Esther Freeman, Erin Theisen, Janice Tiao, Flavia Fedeles, Helen Alexander, Neil Patel, Angela Lo, Adnan Mir, Naveed Sami
Journal: Journal of the American Academy of Dermatology (2022)
Geographical similarity and differences in the burden and genetic predisposition of NAFLD
Authors: Terry Cheuk‐Fung Yip, Eduardo Vilar‐Gomez, Salvatore Petta, Yusuf Yilmaz, Grace Lai‐Hung Wong, Leon A. Adams, Victor de Lédinghen, Silvia Sookoian, Vincent Wai‐Sun Wong
Journal: Hepatology (2022)

NAFLD has become a major public health problem for more than 2 decades with a growing prevalence in parallel with the epidemic of obesity and type 2 diabetes (T2D). The disease burden of NAFLD differs across geographical regions and ethnicities. Variations in prevalence of metabolic diseases, extent of urban–rural divide, dietary habits, lifestyles, and the prevalence of NAFLD risk and protective alleles can contribute to such differences. The rise in NAFLD has led to a remarkable increase in the number of cases of cirrhosis, hepatocellular carcinoma, hepatic decompensation, and liver‐related mortality related to NAFLD. Moreover, NAFLD is associated with multiple extrahepatic manifestations. Most of them are risk factors for the progression of liver fibrosis and thus worsen the prognosis of NAFLD. All these comorbidities and complications affect the quality of life in subjects with NAFLD. Given the huge and growing size of the population with NAFLD, it is expected that patients, healthcare systems, and the economy will suffer from the ongoing burden related to NAFLD. In this review, we examine the disease burden of NAFLD across geographical areas and ethnicities, together with the distribution of some well‐known genetic variants for NAFLD. We also describe some special populations including patients with T2D, lean patients, the pediatric population, and patients with concomitant liver diseases. We discuss extrahepatic outcomes, patient‐reported outcomes, and economic burden related to NAFLD.
Smoldering multiple myeloma current treatment algorithms
Authors: S. Vincent Rajkumar, Shaji Kumar, Sagar Lonial, Maria Victoria Mateos
Journal: Blood Cancer Journal (2022)

Smoldering multiple myeloma (SMM) is an asymptomatic condition that occupies a space between monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) along the spectrum of clonal plasma cell proliferative disorders. It is not a biologic intermediate stage between MGUS and MM, but rather represents a heterogeneous clinically defined condition in which some patients (approximately two-thirds) have MGUS (pre-malignancy), and some (approximately one-third) have MM (biologic malignancy). Unfortunately, no single pathologic or molecular feature can reliably distinguish these two groups of patients. For purposes of practice and clinical trials, specific risk factors are used to identify patients with SMM in whom malignant transformation has already likely occurred (high risk SMM). Patients with newly diagnosed high risk SMM should be offered therapy with lenalidomide or lenalidomide plus dexamethasone (Rd) for 2 years, or enrollment in clinical trials. Patients with low risk SMM should be observed without therapy every 3-4 months.
Fast and Low-GPU-memory abdomen CT organ segmentation: The FLARE challenge
Authors: Jun Ma, Yao Zhang, Song Gu, Xingle An, Zhihe Wang, Cheng Ge, Congcong Wang, Fan Zhang, Yu Wang, Yinan Xu, Shuiping Gou, Franz Thaler, Christian Payer, Darko Štern, Edward G.A. Henderson, Dónal M. McSweeney, Andrew Green, Price Jackson, Lachlan McIntosh, Quoc-Cuong Nguyen, Abdul Qayyum, Pierre-Henri Conze, Ziyan Huang, Ziqi Zhou, Deng-Ping Fan, Huan Xiong, Guoqiang Dong, Qiongjie Zhu, Jian He, Xiaoping Yang
Journal: Medical Image Analysis (2022)
Single‐cell transcriptomics uncovers cellular architecture and developmental trajectories in hepatoblastoma
Authors: Hongting Huang, Liang Wu, Li Lu, Zijie Zhang, Bijun Qiu, Jialin Mo, Yi Luo, Zhifeng Xi, Mingxuan Feng, Ping Wan, Jianjun Zhu, Dingye Yu, Wei Wu, Kezhe Tan, Jiangbin Liu, Qingfeng Sheng, Ting Xu, Jinyan Huang, Zhibao Lv, Yujie Tang, Qiang Xia
Journal: Hepatology (2022)

Hepatoblastoma (HB) is the predominant type of childhood liver cancer. Treatment options for the clinically advanced HB remain limited. We aimed to dissect the cellular and molecular basis underlying HB oncogenesis and heterogeneity at the single-cell level, which could facilitate a better understanding of HB at both the biological and clinical levels.
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis
Authors: Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree
Journal: Hepatology (2022)

Nucleotide-binding oligomerization domain-like receptor-family pyrin domain-containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis. Mechanisms and downstream signaling remain incompletely understood. Here, we studied the role of IL-18 in hepatic stellate cells (HSCs), and its impact on liver fibrosis.
Gastrointestinal dysfunction is associated with mortality in severe burn patients: a 10-year retrospective observational study from South China
Authors: Qiu-Lan He, Shao-Wei Gao, Ying Qin, Run-Cheng Huang, Cai-Yun Chen, Fei Zhou, Hong-Cheng Lin, Wen-Qi Huang
Journal: Military Medical Research (2022)

Abstract Background Data on severe and extensive burns in China are limited, as is data on the prevalence of a range of related gastrointestinal (GI) disorders [such as stress ulcers, delayed defecation, opioid-related bowel immotility, and abdominal compartment syndrome (ACS)]. We present a multicentre analysis of coincident GI dysfunction and its effect on burn-related mortality. Methods This retrospective analysis was conducted on patients with severe [≥ 20% total burn surface area (TBSA)] and extensive (&gt; 50% TBSA or &gt; 25% full-thickness TBSA) burns admitted to three university teaching institutions in China between January 1, 2011 and December 31, 2020. Both 30- and 90-day mortality were assessed by collating demographic data, burn causes, admission TBSA, % full-thickness TBSA, Baux score, Abbreviated Burn Severity Index (ABSI) score, and Sequential Organ Failure Assessment (SOFA) score, shock at admission and the presence of an inhalation injury. GI dysfunction included abdominal distension, nausea/vomiting, diarrhoea/constipation, GI ulcer/haemorrhage, paralytic ileus, feeding intolerance and ACS. Surgeries, length of intensive care unit (ICU) stay, pain control [in morphine milligram equivalents (MME)] and overall length of hospital stay (LOHS) were recorded. Results We analyzed 328 patients [75.6% male, mean age: (41.6 ± 13.6) years] with a median TBSA of 62.0% (41.0–80.0%); 256 (78.0%) patients presented with extensive burns. The 90-day mortality was 23.2% (76/328), with 64 (84.2%) of these deaths occurring within 30 d and 25 (32.9%) occurring within 7 d. GI dysfunction was experienced by 45.4% of patients and had a significant effect on 90-day mortality [odds ratio ( OR ) = 14.070, 95% confidence interval (CI) 5.886–38.290, P &lt; 0.001]. Multivariate analysis showed that GI dysfunction was associated with admission SOFA score and % full-thickness TBSA. Overall, 88.2% (67/76) of deceased patients had GI dysfunction [hazard ratio ( HR ) for death of GI dysfunction = 5.951], with a survival advantage for functional disorders (diarrhoea, constipation, or nausea/vomiting) over GI ulcer/haemorrhage ( P &lt; 0.001). Conclusion Patients with severe burns have an unfavourable prognosis, as nearly one-fifth died within 90 d. Half of our patients had comorbidities related to GI dysfunction, among which GI ulcers and haemorrhages were independently correlated with 90-day mortality. More attention should be given to severe burn patients with GI dysfunction.
High‐Resolution Imaging of the Ocular Vasculature of Conjunctivitis in Mice Using Highly Bright Polymer Dots
Authors: Yuqiao Li, Shuting Lu, Yufan Zhang, Jingru Li, Liqin Xiong
Journal: Advanced Healthcare Materials (2022)

Ocular diseases are mainly caused by vascular aberrations in the eye, and accurate imaging and analysis of the ocular vascular structure is crucial. In this study, poly(9,9-dioctylfluorene-alt-benzothiadiazole) (PFBT) polymer dots (Pdots), with the advantages of easy synthesis, high brightness, and low toxicity, are used as nanoprobes to perform high-resolution imaging of the vasculature of the eyeball and optic nerve. Moreover, rapid imaging of the choroidal microvessels is carried out by stereoscopic fluorescence microscopy with a resolution of up to 1.6 µm. The comprehensive 3D vascular information of retinal aorta and optic nerve microvessels is obtained by combining tissue clearing and multiphoton microscopy. In addition, the vascular density of Schlemm's canal and iris blood vessels is compared between the conjunctivitis mice and the normal mice. These results suggest that PFBT Pdots have great application potential in the fast and accurate imaging of ocular diseases.
Correction: Digital single-operator pancreatoscopy for the treatment of symptomatic pancreatic duct stones: a prospective multicenter cohort trial
Authors: Christian Gerges, David Albers, Lukas Schmitz, Elisabetta Goni, Annalisa Cappello, Jörg Schirra, Markus Casper, Arno J. Dormann, Dirk Hartmann, Marcus Hollenbach, Markus Schneider, Ulrike W. Denzer, Alexander Dechene, Markus Dollhopf, Julia Mayerle, Brigitte Schumacher, Erwin-Jan M. van Geenen, Horst Neuhaus, Peter D. Siersema, Mark Ellrichmann, Torsten Beyna
Journal: Endoscopy (2022)

Correction to: Digital single-operator pancreatoscopy for the treatment of symptomatic pancreatic duct stones: a prospective multicenter cohort trialEndoscopy eFirstDOI: 10.1055/a-1870-3403
Impact of IDH1 and IDH2 mutational subgroups in AML patients after allogeneic stem cell transplantation
Authors: Desiree Kunadt, Sebastian Stasik, Klaus H. Metzeler, Christoph Röllig, Christoph Schliemann, Philipp A. Greif, Karsten Spiekermann, Maja Rothenberg-Thurley, Utz Krug, Jan Braess, Alwin Krämer, Andreas Hochhaus, Sebastian Scholl, Inken Hilgendorf, Tim H. Brümmendorf, Edgar Jost, Björn Steffen, Gesine Bug, Hermann Einsele, Dennis Görlich, Cristina Sauerland, Kerstin Schäfer-Eckart, Stefan W. Krause, Mathias Hänel, Maher Hanoun, Martin Kaufmann, Bernhard Wörmann, Michael Kramer, Katja Sockel, Katharina Egger-Heidrich, Tobias Herold, Gerhard Ehninger, Andreas Burchert, Uwe Platzbecker, Wolfgang E. Berdel, Carsten Müller-Tidow, Wolfgang Hiddemann, Hubert Serve, Matthias Stelljes, Claudia D. Baldus, Andreas Neubauer, Johannes Schetelig, Christian Thiede, Martin Bornhäuser, Jan M. Middeke, Friedrich Stölzel
Journal: Journal of Hematology & Oncology (2022)

The role of allogeneic hematopoietic cell transplantation (alloHCT) in acute myeloid leukemia (AML) with mutated IDH1/2 has not been defined. Therefore, we analyzed a large cohort of 3234 AML patients in first complete remission (CR1) undergoing alloHCT or conventional chemo-consolidation and investigated outcome in respect to IDH1/2 mutational subgroups (IDH1 R132C, R132H and IDH2 R140Q, R172K).Genomic DNA was extracted from bone marrow or peripheral blood samples at diagnosis and analyzed for IDH mutations with denaturing high-performance liquid chromatography, Sanger sequencing and targeted myeloid panel next-generation sequencing, respectively. Statistical as-treated analyses were performed using R and standard statistical methods (Kruskal-Wallis test for continuous variables, Chi-square test for categorical variables, Cox regression for univariate and multivariable models), incorporating alloHCT as a time-dependent covariate.Among 3234 patients achieving CR1, 7.8% harbored IDH1 mutations (36% R132C and 47% R132H) and 10.9% carried IDH2 mutations (77% R140Q and 19% R172K). 852 patients underwent alloHCT in CR1. Within the alloHCT group, 6.2% had an IDH1 mutation (43.4% R132C and 41.4% R132H) and 10% were characterized by an IDH2 mutation (71.8% R140Q and 24.7% R172K). Variants IDH1 R132C and IDH2 R172K showed a significant benefit from alloHCT for OS (p = .017 and p = .049) and RFS (HR = 0.42, p = .048 and p = .009) compared with chemotherapy only. AlloHCT in IDH2 R140Q mutated AML resulted in longer RFS (HR = 0.4, p = .002).In this large as-treated analysis, we showed that alloHCT is able to overcome the negative prognostic impact of certain IDH mutational subclasses in first-line consolidation treatment and could pending prognostic validation, provide prognostic value for AML risk stratification and therapeutic decision making.
A 3D-printed molybdenum-containing scaffold exerts dual pro-osteogenic and anti-osteoclastogenic effects to facilitate alveolar bone repair
Authors: Beimin Tian, Xuan Li, Jiujiu Zhang, Meng Zhang, Dian Gan, Daokun Deng, Lijuan Sun, Xiaotao He, Chengtie Wu, Faming Chen
Journal: International Journal of Oral Science (2022)

The positive regulation of bone-forming osteoblast activity and the negative feedback regulation of osteoclastic activity are equally important in strategies to achieve successful alveolar bone regeneration. Here, a molybdenum (Mo)-containing bioactive glass ceramic scaffold with solid-strut-packed structures (Mo-scaffold) was printed, and its ability to regulate pro-osteogenic and anti-osteoclastogenic cellular responses was evaluated in vitro and in vivo. We found that extracts derived from Mo-scaffold (Mo-extracts) strongly stimulated osteogenic differentiation of bone marrow mesenchymal stem cells and inhibited differentiation of osteoclast progenitors. The identified comodulatory effect was further demonstrated to arise from Mo ions in the Mo-extract, wherein Mo ions suppressed osteoclastic differentiation by scavenging reactive oxygen species (ROS) and inhibiting mitochondrial biogenesis in osteoclasts. Consistent with the in vitro findings, the Mo-scaffold was found to significantly promote osteoblast-mediated bone formation and inhibit osteoclast-mediated bone resorption throughout the bone healing process, leading to enhanced bone regeneration. In combination with our previous finding that Mo ions participate in material-mediated immunomodulation, this study offers the new insight that Mo ions facilitate bone repair by comodulating the balance between bone formation and resorption. Our findings suggest that Mo ions are multifunctional cellular modulators that can potentially be used in biomaterial design and bone tissue engineering.