Durvalumab Plus Carboplatin/Paclitaxel Followed by Maintenance Durvalumab With or Without Olaparib as First-Line Treatment for Advanced Endometrial Cancer: The Phase III DUO-E Trial
Authors: Shannon N. Westin, Kathleen Moore, Hye Sook Chon, Jung-Yun Lee, Jessica Thomes Pepin, Michael Sundborg, Ayelet Shai, Joseph de la Garza, Shin Nishio, Michael A. Gold, Ke Wang, Kristi McIntyre, Todd D. Tillmanns, Stephanie V. Blank, Ji-Hong Liu, Michael McCollum, Fernando Contreras Mejia, Tadaaki Nishikawa, Kathryn Pennington, Zoltan Novak, Andreia Cristina De Melo, Jalid Sehouli, Dagmara Klasa-Mazurkiewicz, Christos Papadimitriou, Marta Gil-Martin, Birute Brasiuniene, Conor Donnelly, Paula Michelle del Rosario, Xiaochun Liu, Els Van Nieuwenhuysen, Sophia Frentzas, Kichendasse Ganessan, Bo Gao, Tarek Meniawy, Linda Mileshkin, Gary Richardson, Felicia Roncolato, Jean-Francois Baurain, Maryam Bourhaba, Eveline De Cuypere, Philip Debruyne, Hannelore Denys, Frederic Forget, Brigitte Honhon, Eric Joosens, Els Van Nieuwenhuysen, Vanessa da Costa Miranda, Andreia Cristina De Melo, Joao Daniel Guedes, Charles Andree Joseph de Padua, Nicolas Lazaretti, Carolina Martins Vieira, Andre Mattar, Daniela Neves Palmeiro, Christina Pimentel Oppermann Kussler, Pedro Emanuel Rubini Liedke, Joao Soares Nunes, Katsuki Arima Tiscoski, Allan Covens, Lara De Guerke, Prafull Ghatage, Lucy Gilbert, Susie Lau, Amit Oza, Diane Provencher, Omar Touhami, Li Congzhu, Wang Danbo, Lou Ge, Zhu Gen-Hai, Li Guiling, Shi Hong, Zheng Hong, Wen Hongwu, Liu Ji-Hong, Wang Jing, Wang Ke, Jiang Kui, Li Li, Wang Li, Hao Min, Zhou Qi, Gao Qinglei, Liao Sihai, Zhang Songling, Zhao Weidong, Xiaohua Wu, Wang Wuliang, Rutie Yin, Cheng Ying, Zhang Yu, Liang Zhiqing, Fernando Contreras Mejia, Angel Luis Hernandez, Carolina Ortiz Lopez, Carlos Javier Pacheco, Pedro Luis Ramos Guette, Jaime Rendon Pereira, Julian Rivera Diaz, Tomas Sanchez Villegas, Juan Pablo Suso, Marco Antonio Torregroza Otero, Karin Grisan, Elen Vettus, Bahriye Aktas, Eva Egger, Petra Krabisch, Andreas Muller, Joachim Rom, Jalid Sehouli, Antje Sperfeld, Pauline Wimberger, Andreas Zorr, George Fountzilas, Sofia Karageorgopoulou, Christos Papadimitriou, Amanda Psyrri, Florai Zagour, Karen Kar Loen Chan, Wing Ming Ho, Tibor Csoszi, Laszlo Landherr, Zoltan Novak, Zsuzsanna Papai, Robert Poka, Istvan Sipocz, Paul Devinder, Lovenish Goyal, Sudeep Gupta, Radheshyam Naik, Tushar Patil, S.P. Somashekhar, Ilan Bruchim, Svetlana Kovel, Anca Leibovici, Ora Rosengarten, Tamar Safra, Wataru Yamagami, Junzo Hamanishi, Yuichi Imai, Nobuhiro Kado, Shoji Kamiura, Hienori Kato, Eiji Kondo, Wataru Kudaka, Takashi Matsumoto, Masahiko Mori, Tadaaki Nishikawa, Shin Nishio, Aikou Okamoto, Mayu Yunokawa, Masayuki Sekine, Toshiyuki Sumi, Hirokuni Takano, Kazuhiro Takehara, Birute Brasiuniene, Arturas Inciura, Goda Jonuskiene, Jesus Elvis Cabrera Luviano, Adriana Dominguez-Andrade, Raquel Gerson-Cwilich, Carlos Hernandez Hernandez, Jesus Lopez Hernandez, Jose Luis Martinez Lira, Jaime Esteban Navarrete Aleman, Jessica Reyes Contreras, Vanessa Rosas Camargo, Wieslawa Bednarek, Dagmara Klasa-Mazurkiewicz, Tomasz Kubiatowski, Piotr Potemski, Magdalena Sikorska, Suk-Joon Chang, Sook Hee Hong, Sokbom Kang, Byoung-Gie Kim, Jan-Weon Kim, Yong Man Kim, Jung-Yun Lee, Sang Young Ryu, Yong Jung Song, Dmitriy Kirtbaya, Julya Kreynina, Alla Lisyanskaya, Yulia Makarova, Rashida Orlova, Albert Pirmagomedov, Valeria Saevets, Sufia Safina, Pavel Skopin, Alexandra Tyulyandina, Sheow Lei Lim, Lynette Ngo Su Mien, David Tan Shao Peng, Lay Tin Soh, Jesus Alarcon Company, Pilar Barretina, Purificacion Estevez-Garcia, Isaura Fernandez Perez, Fernando Galvez, Yolanda Garcia, Marta Gil-Martin, Jeronimo Martinez, Andres Redondo-Sanchez, Charles Anderson, Tara Berman, Stephanie Blank, William Bradley, James Burke, Fabio Cappuccini, Michael Carney, Setsuko Chambers, Lee-May Chen, Hye Sook Chon, Joseph de la Garza, Stephen Depasquale, Paul DiSilvestro, Babak Edraki, Evelyn Fleming, Jenny Fox, Michael Gold, Mary Gordinier, Michael Guy, Ellen Hartenbach, Chisten Haygood, Scott Jordan, Larry Kilgore, Young Kim, Joseph Lucci, Michael McCollum, Michael Mchale, Kristi McIntyre, Mark Messing, Eirwen Miller, Kathleen Moore, John Moroney, Michaela Onstad, Taylor Ortiz, Sobia Ozair, Kathryn Pennington, Krista Pfaendler, Anna Priebe, Terri Pustilnik, Kimberly Resnick, Peter Rose, Erin Salinas, Sudarshan Sharma, Urszula Sobol, Pamela Soliman, David Starks, Michael Sundborg, Eleonora Teplinsky, Jessica Thomes-Pepin, Todd Tillmanns, David Warshal, Shannon N. Westin, Thomas Woliver
Journal: Journal of Clinical Oncology (2023)

Immunotherapy and chemotherapy combinations have shown activity in endometrial cancer, with greater benefit in mismatch repair (MMR)-deficient (dMMR) than MMR-proficient (pMMR) disease. Adding a poly(ADP-ribose) polymerase inhibitor may improve outcomes, especially in pMMR disease.