POS1098 DO THE CHANGES DETECTED BY ULTRASOUND AFFECT THE QUALITY OF LIFE OF YOUNG AND MIDDLE-AGED PATIENTS WITH PSORIATIC ARTHRITIS?
Authors: I. Fairushina, E. Kirillova, D. Abdulganieva
Journal: Annals of the Rheumatic Diseases (2022)

Background The quality of life (QoL) is included in the main domain for psoriatic arthritis (PsA) course assessment. 1 In the last years, the role of imaging has grown up. The European League Against Rheumatism recognized that ultrasound (US) has higher sensitivity than clinical examination to detect inflammatory disease activity. The data showing the association between (b/w) QoL and US changes in PsA is limited. Objectives To study relationship b/w US articular and entheseal involvement and QoL in PsA. Methods 18-60-aged patients (n=92) were enrolled to study with fulfilled PsA criteria (CASPAR, 2006). Clinical and demographical data was fixed. All patients completed questionnaires (Health Assessment Questionnaire-Disability Index (HAQ-DI), FACIT-Fatigue, Dermatology Life Quality Index (DLQI), Short Form – 36 (SF-36). US was done by 2 US rheumatologists - 1288 large joints and 4968 entheses at the projection of these joints (total number - 54) were examined. The following was evaluated: synovitis count (by Grey Scale), Power Doppler(PD)+ synovitis), thickening and hypoechogenicity at enthesis, PD+ enthesitis, entheses with structural components. Entheseal findings were fixed according to consensus-based US definition and scoring for enthesitis in spondyloarthritis and PsA (OMERACT US). 2 Results In all 92 patients: male - 42 (45.7%), mean age was 42.9±9.6 (SD) years (y), PsA duration was 7 (2; 11.8) y, Disease Activity in PsA score was 15.2 (10.2; 21.4). Thus, the impact of psoriasis on the quality of life of patients with PsA was revealed. DLQI scores correlated with skin psoriasis activity and nail onychodystrophy, as well as clinical enthesitis (p&lt;0,01). Minimal (67.4%) and moderate (29.3%) disability levels were found. HAQ-DI scores were associated with higher PsA activity and duration, age and clinical enthesitis (p&lt;0,01). Physical and mental health (SF-36) correlated with Disease Activity in PsA and clinical enthesitis (p&lt;0,05). Fatigue was found in 50% of patients and increased with PsA activity and duration, and clinical enthesitis (р&lt;0,01). US data showed no association with QoL in PsA (p&gt;0.05). Conclusion QoL scores of this study were related to clinical data, particularly to clinical enthesitis. US articular and entheseal inflammation were not correlated with QoL scores. This is probably due to the subclinical course of US changes. This allows us to conclude that QoL is associated with clinical than with US characteristics in PsA. References [1]Ogdie A, de Wit M, Callis Duffin K, et.al. Defining Outcome Measures for Psoriatic Arthritis: A Report from the GRAPPA-OMERACT Working Group. J Rheumatol.;2017;44(5):697-700. [2]Balint PV, Terslev L, Aegerter P, et al. Reliability of a consensus-based ultrasound definition and scoring for enthesitis in spondyloarthritis and psoriatic arthritis: an OMERACT US initiative. Ann Rheum Dis.;2018;77(12):1730-1735. Disclosure of Interests None declared