tbuckley/cabot-search huggingface dataset:
Bergey's Manual of Determinative Bacteriology: A Key for the Identification of Organisms of the Class Schizomycetes
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Leukocyte Count
Authors: Cynthia S. Hardison
Journal: JAMA (1968)

The leukocyte count is a valuable part of the laboratory evaluation of the patient. Disposable pipets which are now available provide automatic measuring and easy mixing, and results are comparable to those obtained with glass pipets.<sup>1</sup>Errors in determining the total leukocyte count vary from 7% to 20%. If the count is very high, an erythrocyte pipet should be used and the necessary correction for dilution made. Appropriate corrections must also be made when nucleated erythrocytes are present in considerable number since the nuclei of these cells are not lysed by leukocyte diluting fluids. Counts done on capillary blood may be higher by 1,000 to 1,500/cu mm than those done on venous blood. This is probably due to local stasis of leukocytes. Differential count of leukocytes is absolutely essential for proper interpretation of the total leukocyte count. The white blood count (WBC) is high shortly after birth and fluctuates
Handbuch der pathogenen Mikroorganismen.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heredity and Environment: Studies in the Genesis of Psychological Characteristics
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Amino acid transport and glutathione homeostasis: What is the mechanism for cysteine uptake from bile?
Authors: Mark E. Mailliard
Journal: Hepatology (1993)

Transport of L-cysteine and a cysteine S -conjugate, S -(1,2-dichlorovinyl)-L-cysteine (DCVC) was investigated in rat liver canalicular plasma membrane (cLPM) vesicles. Cysteine uptake into an osmotically active intravesicular space was temperature sensitive and further enhanced by an inwardly directed Na + gradient. Na + -dependent and -independent L-cysteine uptake exhibited saturation kinetics with apparent K m of 53 ± 0.7 and 1300 ± 300 μM and V max of 95 ± 21 and 1600 ± 200 pmol ± mg protein −1 ; 10 sec −1 for the Na + dependent components, and an apparent K m of 207 ± 48 μM and a V max of 355 ± 71 pmol ± mg protein −1 ± 10 sec −1 for the Na + -independent component. Na + -dependent uptake was inhibited by L-alanine, glycine, L-phenylalanine and L-leucine, whereas Na + -independent uptake was inhibited by L-phenylalanine, L-leucine and 2-amino-2-norbornanecarboxylic acid. Both Na + -dependent and -independent L-cysteine transport processes were inhibited by several cysteine S -conjugates, with DCVC having the strongest effect. Inhibition of [ 35 S]-cysteine uptake by DCVC was noncompetitive with a K, of 1.2 ± 0.1 mM. On the other hand, uptake of [ 35 S IDCVC by the rat cLPM vesicles was not stimulated by a Na + -gradient, but was inhibited by several other amino acids, including L-cysteine. Further investigation of [35SlDCVC uptake in rat cLPM vesicles indicated a saturable Na + -independent process with an apparent K, of 155 f 42 μM, and a V max of 393 f 53 pmol mg protein −1 5 sec −1 . Time-dependent nonspecific binding of DCVC to rat cLPM vesicles was diminished by addition of aminooxyacetic acid, an inhibitor of cysteine conjugate β-lyase activity. These findings demonstrate that cysteine and DCVC uptake into cLPM vesicles occurs by both saturable and nonsaturable transport mechanisms. These transport pathways may function in vivo for uptake and recycling of biliary L-cysteine for glutathione turnover and some cysteine S-conjugates for intrahepatic mercapturic acid biosynthesis.
Dietary Allergy and Specific IgE in Ulcerative Colitis
Authors: D B Jones, G D Kerr, J H Parker, R S E Wilson
Journal: Journal of the Royal Society of Medicine (1981)

Previous authors have considered that allergy to certain foodstuffs may play an important role in the aetiology of ulcerative colitis, but immunological evidence for dietary allergy in ulcerative colitis is inconclusive. A study is reported of 22 patients with ulcerative colitis, with matched controls, in whom total serum IgE and specific IgE to certain foodstuffs have been estimated by the Phadebas PRIST and RAST (Pharmacia) techniques. Allergens tested were egg-white, milk, wheat, rye, oat, fish (cod) and peanut. There was no significant difference in the total serum IgE levels and the food specific IgE activity between the two groups.
Urethan Carcinogenesis in Rats: Importance of Age and Dose&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: V. R. Choudari Kommineni, D.V.M., Melvin Greenblatt, M.D., S. D. Vesselinovitch, D.V.M., D.V.Sc., N. Mihailovich, D.V.M.
Journal: JNCI Journal of the National Cancer Institute (1970)

Neonatal and adult rats developed a wide spectrum of neoplasms after treatment with varying concentrations of urethan solutions. Neonatal rats had significantly more neurilemmomas than adult rats (4.5 or 6 wk old). Among neonatal rats, the incidence of neurilemmomas was directly related to the concentration of urethan solution injected, rather than to the total dose. All neurilemmomas were benign. A few neurogenic tumors were malignant. Neonatal and adult rats developed both malignant and benign liver tumors. However, the adult rats had fewer liver tumors. Rats exposed to urethan, by the injection of the pregnant mother 48 hours before parturition, had no neurilemmomas or liver tumors. Adult rats developed thyroid tumors, whereas none of the neonatal rats did.
A Practical Treatise on Diseases of the Skin, for the Use of Students and Practitioners.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Applications of A Transcutaneous Ultrasonic Flow Detector
Authors: Robert F. Rushmer
Journal: JAMA (1967)

The limits of human perception have been extended enormously by modern technological advances which permit acquisition of quantitative data from outer space or from the submicroscopic realms of atomic nuclei. Engineers employ exquisitely sensitive gauges to analyze the function of machines and components. Meanwhile, physicians still depend heavily on their unaided five senses to obtain clinical data in routine patient care. Recent developments in the use of nondestructive testing techniques for detecting the size, position, displacement, or flow in internal structures of the body provide a preview of things to come in clinical medicine. For example, a small device has been developed for detecting blood-flow velocity in deep and superficial vessels by merely applying a probe to the body surface. This instrument called a transcutaneous Doppler flow detector (Fig 1) is currently being evaluated for its applicability to clinical problems,<sup>1 -3</sup>eg, locating and evaluating arterial occlusions,<sup>4</sup>detecting
Peak expiratory flow is a prognostic indicator in elderly people
Authors: R. Tilvis, J. Valvanne, S. Sairanen, A. Sovijarvi
Journal: BMJ (1997)

Interferon beta in multiple sclerosis Reducing frequency and severity of relapses will be of great clinical benefitEditor-Richard G Richards's editorial on interferon beta in multiple sclerosis deals with the "clinical cost effectiveness" of the drug in the disease, but it lacks a fair balance, emphasising the cost effectiveness and minimising the clinical effectiveness of the drug. 1 Richards states that "the studies showed no evidence of any reduction in the more clinically relevant endpoint-the progression of disability, which should be the goal of treatment."This is his personal judgment and does not reflect the needs and wishes of patients with multiple sclerosis and their families.Multiple sclerosis is a distressing, humiliating, and often long drawn out disease with no cure.For this reason, quality of life, for the patients and their families, is paramount.A drug that can reduce the frequency and severity of relapses, whether or not it diminishes the progression of the disease, will be of great clinical benefit to many patients, improving their situation physically, psychologically, and socially.Surely happiness, feeling better, and increased health have great value.This is what many of us believe that the practice of our profession is about.
Graduate Medical Education
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial Board and Contents
Authors: Caryn Navarro, Danielle Loughlin, Paige Shaklee, Anna Sojkowska, Ria Otten, Patrick Scheffmann, Erik Andersen, Kirsten Bomblies, Martha Bulyk, Ling Chen, Andy Clark, Sue Clark, Susan Gasser, David Goldstein, Leonard Guarente, Yoshihide Hayashizaki, Steven Henikoff, Chris Hittinger, Laurence Hurst, Angela Nieto, Chris Ponting, Claudio Scazzocchio, Bob Schmitz, Nicole Soranzo, Trisha Wittkopp, Joanna Wysocka
Journal: Trends in Genetics (2016)
AIDS Commission Experiences More Changes
Authors: Charles Marwick
Journal: JAMA (1987)

THE PRESIDENTIAL Commission on the Human Immunodeficiency Virus (HIV) Epidemic keeps running into trouble. On the heels of the forced resignation of its executive director, Linda Sheaffer (<i>JAMA</i>1987;258:2023-2024), two leading members—W. Eugene Mayberry, MD, chair, and Woodrow A. Myers, MD, co-chair—now also have resigned. Taking over as chair is ADM (Ret) James D. Watkins, a former chief of US Naval Operations. Shortly after his appointment, Watkins announced that Polly L. Gault, former staff director of the Senate Subcommittee on Education, Arts, and the Humanities, would become the commission's executive director. Gault, he said, "has a background in education and health, is thoroughly familiar with the legislative process, and has proven managerial talent—precisely the person needed at this critical juncture." Watkins said he would have additional staff appointments to announce in the near future. Also, he said, the White House has informed him that two new commission members soon will
Finding the Most Reliable Dope on Doping
Authors: Andrew A. Skolnick
Journal: JAMA (1996)

EVEN ATHLETES who have no interest in taking performance-enhancing substances need to learn about the substances that they may be tested for. The innocent use of the wrong over-the-counter cold remedy or an herbal tea from a health food store could land them in a lot of trouble with their sport's governing body. At the very least, the athlete's physician should be able to advise him or her where to get the most up-to-date information on substances that are prohibited by the athlete's sport governing body, says Lyn R. Frumkin, MD, PhD, associate director for clinical research at Amgen, Thousand Oaks, Calif. Frumkin is one of the US Olympic Committee's (USOC's) physician crew chiefs who supervise the collection and processing of urine samples from US Olympic athletes. The USOC, which operates a complete drug-testing program equivalent to the International Olympic Committee's (IOC's) program, distributes an official list of banned substances.
Lymphoproliferative responses to<i>Borrelia burgdorferi</i>in circumscribed scleroderma
Authors: F. BREIER, H. KLADE, G. STANEK, C. POITSCHEK, R. KIRNBAUER, W. DORDA, E. ABERER
Journal: British Journal of Dermatology (1996)

Summary Humoral immune responses to Borrelia hurgdorferi (Bb) have been reported to occur in certain patients with circumscribed scleroderma (CS) (morphoea). Together with the isolation of spiro-chaetes from CS skin biopsies, this finding was taken to suggest Bb as the aetiological agent of CS. Since there is cellular immunoreactivity to Bb in patients with chronic Lyme borreliosis (LB). Bb-specific lymphocytic responses were tested in patients with CS. For this purpose, peripheral blood mononuclear cells from CS patients and. as controls, from patients with various manifestations of LB, and from healthy volunteers without any evidence of Bb infection, were exposed to Bb organisms for 5 days and then assayed for DNA synthesis. Stimulation indices (SI)> 10 were scored positive. By performing lymphocyte proliferation tests we found: (i) that not only patients with various manifestations of LB but also a considerable percentage of seropositive (five of 13 = 38%) and seronegative (six of 26 = 23%) CS patients exhibit an elevated Bb-induced lymphocyte proliferation; (ii) that the magnitude of the cellular response seen in CS patients is comparable to that encountered in patients with established Bb manifestations; and (iii) that, within a given patient, antibiotic therapy can result in a significant reduction of this response. These results support a causative role of Bb in at least some CS patients. Bb-induced lymphocyte responses were also seen in both seropositive and seronegative erythema chronicum migrans patients. These findings show that the pattern of Bb-specific immune responses is more complex than previously thought, and underscore the importance of lymphocyte function assays in evaluating the diagnosis of potential Bb infection in seronegative patients.
Critical Incidents in the Shaping of Medical Education in the US
Authors: William Frederick Norwood
Journal: JAMA (1965)

There can be no doubt that the organization and presentation of a curriculum in medicine at the College of Philadelphia in 1765, the first medical school in the English-speaking New World, was a momentous event in medical education. In support of their decision to institute a medical school, the College trustees invited Dr. John Morgan, chief promoter of the school, to give the commencement address in May, 1765. After completing an apprenticeship in Philadelphia, John Morgan had earned the MD degree at the University of Edinburgh and subsequently received professional honors while visiting London and the Continent. He had been home only a few weeks when the college trustees, influenced by persuasive letters of recommendation from abroad, elected him the professor of theory and practice of medicine and offered him the commencement platform. His address, the primer of American medical education, contained sound guide lines for the development of medicine
QUINIDIN TREATMENT OF AURICULAR FIBRILLATION
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Toward Smoke-Free VA Hospitals
Authors: Patricia J. O'Neil
Journal: JAMA (1989)

<h3>To the Editor.—</h3> Prompted by the contents of three Letters to the Editor from Veterans Administration (VA) physicians, I thought it appropriate to advise you and your readers of the December 22, 1988, announcement by the Chief Medical Director of the VA's Department of Medicine and Surgery. In a press release, Dr John A. Gronvall announced his intentions to establish a smoke-free environment in all acute-care VA facilities. Dr Gronvall indicated that this is part of the national effort to achieve a smoke-free society by the year 2000 and noted that the Department of Medicine and Surgery is making every effort to ensure that the environment in its facilities promotes the health and well-being of patients and employees. While the national implementation effort is pursued by the advisory task force appointed by the Chief Medical Director, all VA medical centers have been encouraged to continue their local efforts to achieve
The Risk of Bacterial Endocarditis During Antirheumatic Prophylaxis
Authors: Eugenie F. Doyle
Journal: JAMA (1967)

This study was undertaken to determine whether continuous antirheumatic prophylaxis increased the risk of bacterial endocarditis (BE) or of its resistance to therapy. Sixteen episodes of BE occurred among children and adolescents with rheumatic heart disease who had been treated prophylactically for 3,615 patient years, a rate of 4.4 episodes per 1,000 patient years. This rate is similar to that observed in the preprophylactic era. The onset of BE in these patients often simulated a recurrence of rheumatic fever because of the frequent joint manifestations. Therefore, blood cultures are indicated whenever a patient with rheumatic heart disease has joint symptoms. Eight of the 16 organisms isolated were sensitive to penicillin in vitro; four were slightly sensitive; and four were resistant. The resistance was not of sufficient magnitude to interfere with a satisfactory therapeutic response. These data suggest no increased risk of BE in patients being treated prophylactically.