tbuckley/cabot-search huggingface dataset:
Perioperative Evaluation of a Patient With Abdominal Aortic Aneurysm
Authors: Michael D. Hostetler
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemiology of Familial Predisposition for Breast Cancer in Japan&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1982)

The physical and reproductive traits known to be risk factors for breast cancer were correlated with familial predisposition for this disease by the use of hospital records of 3,867 patients with breast cancer, of whom 186 had one or more relatives with breast cancer and were called “familial patients.” Various characteristics in the total series of patients were compared with familial patients matched for year of birth. The mean age at menarche was significantly less in familial compared with the total series of patients, especially for premenopausal patients; however, no difference was observed in the mean age at marriage between the two groups. Familial patients were slightly taller as compared to the total series of patients, but no difference was detected in body weight between the two groups. Because age at menarche and the stature are highly correlated, they may be influenced by an underlying common hormone effect that may influence the familial nature of breast cancer.
Communicating Science to the Public
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypercalcemia and Streptozotocin
Authors: ERIC A. LARYEA
Journal: Annals of Internal Medicine (1974)

Comments and Corrections1 February 1974Hypercalcemia and StreptozotocinERIC A. LARYEA, M.D., ROBERT BRODRICK, M.D., ROBERT HIDVEGI, M.D.ERIC A. LARYEA, M.D.Search for more papers by this author, ROBERT BRODRICK, M.D.Search for more papers by this author, ROBERT HIDVEGI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-2-276 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I read with interest the article, "Islet Cell Tumors: Current Concepts and Management," by Schein and associates (Ann Intern Med79:239-257, 1973). Their scholarly discussion and presentation of various side effects of streptozotocin were impressive. We have used streptozotocin in a case of malignant insulinoma with multiple liver metastasis. In our case, there was severe hypoglycemia, successfully treated with streptozotocin administered on the same drug schedule as that described by Schein. High levels of calcium present before starting streptozotocin therapy reverted to normal levels after therapy. A review of the literature showed three other cases in which...References1. STANLEYMARKSKREEL NVL: Streptozotocin treatment of malignant islet cell tumour. Br Med J 3:562-563, 1970 CrossrefMedlineGoogle Scholar2. TAYLORSCHWARTZZANNINI STJ: Streptozotocin therapy for metastatic insulinoma. Arch Intern Med 126:654-657, 1970 CrossrefMedlineGoogle Scholar3. SMITHSTOLLVANCE CRJ: Treatment of malignant insulinoma with streptozotocin. Diabetologia 7:118-124, 1971 CrossrefMedlineGoogle Scholar1. DEWYSSTOLLAU WRW: Effects of streptozotocin on an islet cell carcinoma with hypercalcemia. Am J Med 55:671-676,1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Queen Elizabeth Hospital Montreal, Quebec Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByOccult sarcoidosis as the cause of hypercalcemiaHypercalc�mie bei malignen ErkrankungenMetastatic pancreatic islet cell carcinoma with peptic ulcer disease and hypercalcemiaPancreatic islet cell carcinoma with hypercalcemia and hypergastrinemia.Response to streptozotocinFasting hypoglycemia, hypercalcemia and hyperprolactinemia 1 February 1974Volume 80, Issue 2Page: 276-277KeywordsCalciumDrugsHypercalcemiaHypoglycemiaInsulinomaLiver Issue Published: 1 February 1974 PDF DownloadLoading ...
Correction: Medical News &amp;amp; Perspectives on Needle Exchange Programs
Authors: Peter Lurie
Journal: JAMA (1995)

<h3>To the Editor.</h3> —Charles Marwick's Medical News &amp; Perspectives article<sup>1</sup>on the Foundation for Drug Policy's March congressional forum on needle exchange programs (NEPs) contains an error that should be corrected. The article states that the three-volume, 700-page report<sup>2</sup>I prepared with colleagues from the University of California for the Centers for Disease Control and Prevention (CDC) has never been released by the US Department of Health and Human Services. In fact, more than 12 000 copies of the various volumes of the report have been distributed since the report was released in the fall of 1993, almost all by the CDC's National AIDS Clearinghouse. What had not been released were internal government documents on NEPs, one of which reviewed the University of California report shortly after its release. After consulting with four other federal agencies, CDC Director Dr David Satcher wrote to the US Department of Health
The Organism: A Holistic Approach to Biology Derived from Pathological Data in Man
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Influence of Strong, Prevalent, Rain-Bearing Winds on the Prevalence of Phthisis.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Manual of Clinical Allergy.
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Post-Traumatic Syndrome: Another Myth Discredited
Authors: Reginald Kelly, B Norman Smith
Journal: Journal of the Royal Society of Medicine (1981)

Further studies confirm the authors’ previous contention that patients suffering from the post-traumatic syndrome (PTS) do recover from this syndrome and return to full-time work before litigation is settled. Failure to have returned to work by the time of settlement indicates a bad prognosis, and such patients rarely return to work afterwards; the older the patient the worse the prognosis.
Leads from the MMWR. Number of sex partners and potential risk of sexual exposure to human immunodeficiency virus
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights of This Issue
Journal: Clinical Cancer Research (2017)

Factors influencing the efficacy of abiraterone in suppressing tumor growth in castration-resistant prostate cancer (CRPC) are not well understood. Based on its steroidal structure, Mostaghel and colleagues hypothesized that abiraterone may be transported by the SLCO family of androgen transporters. In vitro, prostate cancer cells expressing SLCO2B1 showed higher abiraterone uptake when compared with controls. In a neoadjuvant trial of abiraterone prior to prostatectomy, genetic variation in SLCO2B1 was associated with tissue abiraterone levels and rates of minimal residual disease. These data suggest variation in SLCO genes may serve as predictors of response to abiraterone treatment in men with CRPC.KRAS mutation was reported as a contributor to acquired cetuximab resistance in metastatic colorectal cancer. To explore whether other mutations in genes downstream of EGFR confer acquired resistance to cetuximab-based therapy, Xu and colleagues designed a strategy to identify low-frequency candidate mutations that are associated with acquired cetuximab resistance by sequencing circulating tumor DNA taken from patient plasma samples obtained before and during treatment. Five novel mutations in exon 19 and hotspot PIK3CA mutations were identified, which contribute to acquired cetuximab resistance. The role of PIK3CA mutations in acquired cetuximab resistance appears to be comparable with that of KRAS mutations.In patients treated with pembrolizumab, tumor burden increase of less than 20% from baseline during therapy was noted in 55% of the patients and was associated with longer overall survival, proposing a practical prognostic marker that may objectively guide treatment decisions. Pseudoprogression was noted in 4 among 107 patients (4%), including one patient without measurable tumor burden at baseline, which is indicative of a need for increased attention to nonmeasurable tumor burden in the context of immunotherapy.Reliable and reproducible methods for detecting PD-L1 expression in tumors is crucial for identifying patients who respond to anti-PD-1 therapy. The PD-L1 IHC 22C3 pharmDx is a companion diagnostic developed by Dako to identify non-small cell lung cancer patients who are likely to derive benefit from treatment with pembrolizumab. Using this assay, Cooper and colleagues investigated the inter- and intra-observer reproducibility of pathologists' assessment of PD-L1 staining and the impact of training on reproducibility. They demonstrated good agreement at both 1% and 50% cut-points. A one-hour training session had minimal impact on the reproducibility.
Corrections
Authors: Nicholas Donato, Ji Wu, Jonathan Stapley, Hui Lin, Ralph Arlinghaus, Bharat Aggarwal, Shishir Shishodia, Maher Albitar, Kimberly Hayes, Hagop Kantarjian, Drs Csiszar, Sheri Fong
Journal: Cancer Research (2004)

lysyl oxidase gene family did not include the gene symbols currently recognized and approved by the HUGO Gene Nomenclature Committee and Mouse Genome Informatics database.As has been reported in recent reviews (2-4), the human lysyl oxidase gene family members are referred to as LOX or LO, LOXL or LOXL1, LOXL2, LOXL3, and LOXL4.Akiri and colleagues acknowledge that when preparing their manuscript they were aware that there were two different nomenclatures for the lysyl oxidases, as discussed in their introduction, but they chose the one not approved, as they were unaware that an official nomenclature had been adopted by the HUGO Nomenclature Committee.
Highlights of This Issue
Journal: Clinical Cancer Research (2011)

The epidermal growth factor receptor (EGFR) is a therapeutic target in cervical cancer.By using different antibodies binding the extracellular and intracellular domain of the receptor respectively, Halle and colleagues found that ectodomain isoforms generated from alternative transcripts showed a strong relationship to poor outcome of lymph node-negative patients when not coexpressed with the full-length receptor in the membrane.These findings may shed light on possible mechanisms of treatment resistance in EGFR trials and point to the expression of ectodomain EGFR isoforms as a novel biomarker for relapse after conventional chemoradiotherapy.The VEGFR-2 receptor mediates angiogenic endothelial cell responses and is a target ofseveral smallmolecule angiogenesis inhibitors.To characterize genetic variation in KDR, the gene encoding VEGFR-2,Glubb and colleagues performed resequencing studies in groups of healthy Caucasian, African American, and Asian individuals.Bioinformatic and in vitro analyses revealed several functional KDR variants that associated with either microvessel density,KDR mRNA, or VEGFR-2 protein levels in non-small cell lung cancer tumor samples.These genetic variants may act as prognostic or predictive markers and should be tested for associations with outcomes of patients treated with angiogenesis inhibitors.Relapsing classical Hodgkin lymphoma (HL) is thought to represent recurrence of the previous neoplasia. Here, Obermann and colleagues investigated, in a collective of 20 patients, whether the first and all subsequent manifestations of HL in a patient are clonally related. Reed-Sternberg and Hodgkin cells were microdissected and assessed by immunoglobulin heavy chain gene fragment lengths analysis and sequencing.Most relapses were clonally related to the initial diagnosis or, if multiple, to each other, whereas a third relapse seemed to represent clonally unrelated neoplasms.These findings suggest that clonally unrelated relapsed HL may exist, which might merit further evaluation considering treatment strategies.Because DNA repair processes are defective in cancer cells, the development of nontoxicagents that can selectively induce DNA damage in cancer cells represents a promising avenue for therapeutic intervention.Here, Tyagi and colleagues report that resveratrol was able to cause S phase arrest, checkpoint activation, and apoptotic death of head and necksquamous cell carcinoma (HNSCC)cells, but had little effect on normal cells.Similar results were also observed in vivo using tumor xenografts.Their data indicate that the anticancer effect of resveratrol is predominately due to its ability to induce DNA damage selectivelyin HNSCC cells without affecting normal, repair-proficient cells.
An Outbreak of Mycoplasma pneumoniae Infection in a Nuclear Submarine
Authors: Robert Sawyer
Journal: JAMA (1966)

A NUMBER OF STUDIES have drawn attention recently to the association between acute respiratory infections and the presence in the respiratory tract of<i>Mycoplasma pneumoniae</i>in civilian<sup>1,2</sup>and in military populations.<sup>3,4</sup>The symptomatology has varied from a mild illness, resembling the common cold, through severe and deep-seated pneumonitis with pronounced constitutional upset. We recently had the opportunity to study an outbreak of respiratory illness due to this agent which occurred among the crew members of a nuclear submarine on patrol, and, as many of the features were of unusual interest, we describe them here. <h3>Outbreak</h3> This occurred on board a fleet ballistic-missile submarine operating from Holy Loch, Scotland. The crew is based in New London, Conn and flies to Scotland three weeks before deployment on patrol. Each patrol lasts eight weeks and the crew is continuously isolated from the surface atmosphere for seven of these weeks. During this
THE ADRENOGENITAL SYNDROME
Journal: JAMA (1960)

HE adrenogenital syndrome due to congenital adrenocortical hyperplasia is another example of an inborn error of metabolism in man, which has enjoyed closer scrutiny and etiological clarification in recent years. This condition is hereditary and behaves as a Mendelian recessive characteristic. Its imprint is heavier on female children, in whom it produces masculinization of the external genitalia owing to the initiation of the disorder during fetal life. This disease constitutes one of the commonest causes of female pseudohermaphroditism. The incrimination of the adrenal cortex in this syndrome has long been a matter of morphologic record—in patients who died, this gland was many times normal size. Since the availability of the Zimmermann reaction for the measurement of urinary 17-ketosteroids, it has repeatedly been shown that the androgens (of adrenal origin) are regularly elevated in patients with this condition. In recent years, the administration of hydrocortisone or its many analogs has been
Mozart's Illnesses and Death<sup>1</sup>
Authors: Peter J Davies
Journal: Journal of the Royal Society of Medicine (1983)

Throughout his life Mozart suffered frequent attacks of tonsillitis. In 1784 he developed post-streptococcal Schönlein-Henoch syndrome which caused chronic glomerular nephritis and chronic renal failure. His fatal illness was due to Schönlein-Henoch purpura, with death from cerebral haemorrhage and bronchopneumonia. Venesection(s) may have contributed to his death.
Immunochemical Characterization of Fetal Antigen Isolated From Spent Medium of a Human Melanoma Cell Line&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Gupta, Rishab K., Morton, Donald L.
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Immunochemical Characterization of Fetal Antigen Isolated From Spent Medium of a Human Melanoma Cell Line Get access Rishab K. Gupta, Rishab K. Gupta 6 4Division of Surgical Dncology, John Wayne Clinic, Jonsson Comprehensive Cancer Center, University of California at Los Angeles (UCLA) School of Medicine, Los Angeles, Calif. 900245Surgical Service, Veterans Administration Medical Center, Sepulveda, Calif. 91343 6Address reprint requests to Dr. Gupta, Division of Surgical Oncology, 9th Floor, Louis Factor Building, UCLA School of Medicine, Los Angeles, Calif. 90024. Search for other works by this author on: Oxford Academic PubMed Google Scholar Donald L. Morton Donald L. Morton 4Division of Surgical Dncology, John Wayne Clinic, Jonsson Comprehensive Cancer Center, University of California at Los Angeles (UCLA) School of Medicine, Los Angeles, Calif. 900245Surgical Service, Veterans Administration Medical Center, Sepulveda, Calif. 91343 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 70, Issue 6, June 1983, Pages 993–1004, https://doi.org/10.1093/jnci/70.6.993 Published: 01 June 1983 Article history Received: 08 June 1982 Revision received: 08 December 1982 Accepted: 04 February 1983 Published: 01 June 1983