tbuckley/cabot-search huggingface dataset:
Amyloidosis
Authors: Martin Swerdlow
Journal: JAMA (1969)

This book, a report of a conference on amyloidosis held in The Netherlands in September 1967, is an indepth review of virtually all that is known about amyloid, at least to that point in time. Written by experts in many different branches of science, the book is divided into seven parts: a general section, a section on the cellular aspects of pathogenesis, a section on immunological aspects, a section on electron microscopy, a section on the histochemistry and chemical composition of amyloid, a section on experimental amyloidosis, and finally a section on clinical studies. The book not only reviews but critically discusses previously held notions and concepts. It brings to light innumerable problems that still exist in the understanding of the basic nature and genesis of amyloid, suggests possible answers, and at the same time presents many new ideas particularly for experimental approaches to the solutions of some of these
PLoS Medicine Issue Image | Vol. 2(2) February 2005
Journal: PLoS Medicine (2005)

We live in a society saturated with images, information, and rapidly evolving technology. As an artist, one of my interests is exploring the way our accelerating culture affects who we are and challenges our perception of reality. My work both participates in and reacts to the chaotic, fragmented, and sometimes obsessive-compulsive quality that seems to pervade our lives. Weekly Pills explores pill-taking as a daily, ritualistic activity and the obsession to alter, fix, or enhance who we are physically and mentally. Today, you can take a pill for practically any ailment or problem—from relieving a headache, to boosting sexual performance, stimulating hair growth, or improving your emotional state. Pills satisfy our desire to control nature through technology and symbolize our longing to attain perfection and wholeness. Weekly Pills is from the series Specimens, which plays upon scientific study to explore the relationship between physical objects and personal experience. For Specimens, I collected pills from people who shared personal narratives associated with each pill. Found images were integrated to illustrate individual stories, and the pills and images were organized into plastic pillboxes and embedded in a resin casting. The final piece functions as a type of specimen box, revealing cultural and personal implications and meaning. Krista Steinke is a mixed media artist who works primarily in photography, video, new media, and installation. She received a B.A. in Advanced Humanities from Valparaiso University, with a minor in Psychology, a B.F.A. in studio art from the School of the Art Institute of Chicago, and an M.F.A. in photography and digital imaging from the Maryland Institute, College of Art. She has exhibited nationally, her work is included in many public and private collections, and her photographs have been featured on book covers. Currently, Krista is Assistant Professor of Art at Moravian College in Bethlehem, Pennsylvania. Image Credit: Krista Steinke (www.kristasteinke.com)
Olympic Athletes Participate In Long-Term Health Study
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trend to specialization reversing?
Authors: C. Marwick
Journal: JAMA (1992)

THE AMERICAN health care system is top-heavy with specialists, critics say. Efforts are getting under way to reverse the trend on grounds that a system dominated by specialties results in ever-increasing costs and lack of access to basic care. But it's uphill work. That is the conclusion of experts attending a recent Washington, DC, conference on primary care sponsored by the Department of Health and Human Services. It was held at a time when some states even are considering reducing state university medical school funding if the institutions do not graduate more primary care physicians. Stuart H. Altman, PhD, dean, Brandeis University, Waltham, Mass, notes that, in virtually all developed nations, primary care physicians predominate. "In Australia," he says, "73% of physicans are primary care providers, in Canada it's 52%, in West Germany 45%, in Great Britain 70%, but in the United States it's 33% and falling." Steven A. Schroeder,
Effect of Quinacrine on Neoplastic Effusion and Certain of Their Enzymes
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GE-10 * IDENTIFICATION OF PATIENTS WITH RECURRENT GBM THAT BENEFIT FROM BEVACIZUMAB
Authors: L. E. Eraslan, M. van den Bent, J. Kros, H. Oosterkamp, A. Walenkamp, L. Beerepoot, M. Hanse, J. Buter, A. Honkoop, B. van der Holt, R. M. Vernhout, P. S. Smitt, W. Taal, P. French
Journal: Neuro-Oncology (2014)

INTRODUCTION: To assess the effects of bevacizumab (BEV) in recurrent GBMs, a three-arm randomized phase II study was initiated (the BELOB trial) comparing BEV monotherapy, CCNU monotherapy and BEV + CCNU combinationtherapy. Primary endpoint was 9 months OS and was 38% [25,51], 43% [29,57] and 59% [43,72] in the BEV, lomustine and combination arms respectively. The BELOB trial results therefore provide evidence for clinical efficacy of BEV, at least in a recurrent GBM setting and when given in combination with lomustine. However, not all patients in this trial appeared to benefit equally from the combination treatment. In this study, we therefore aimed to identify patients that benefit from BEV. METHODS: RNA expression profiling was performed using DASL (Illumina, n = 118) and RNA sequencing (n = 78) of samples. RESULTS: The DASL and RNA-seq platform both show a high concordance between technical and biological replicates and with expression profiling on snap frozen tissue samples. Sample assignment to one of seven 'intrinsic glioma subtypes' (IGS; molecular subtypes of glioma based on similarities in gene-expression profiles [PMID: 19920198]) was also highly similar between the different platforms. Analysis of BELOB samples shows that most are assigned to poor prognostic subtypes (IGS-18 "EGFR-amplified, classical" n = 73 and IGS-23 "mesenchymal" n = 28). Nine patients were assigned to prognostically more favourable subtypes (IGS-9 and IGS-17), but these do not explain the more favourable outcome in the BEV + CCNU arm. Patients with tumors assigned to IGS-18 show benefit from combined treatment with bevacizumab + CCNU. In contrast, tumors assigned to IGS-23 may have worse performance in this arm, though patient numbers are small. CONCLUSIONS: DASL and RNA-seq perform well on RNA isolated from FFPE tissues stored (up to 20 years) in paraffin. Specific molecular subtypes of recurrent GBM show benefit from BEV + CCNU treatment.
HBV vaccine immunogenic in neonates
Authors: C. Marwick
Journal: JAMA (1983)

Evidence that immunization of infants with hepatitis B vaccine is effective was reported at the recent annual meeting of the American Gastroenterological Association in Washington, DC, by Cladd Stevens, MD, of the New York Blood Center, New York City. Stevens has studied more than 400 children in Eastern Transvaal, a region where infection with hepatitis B virus (HBV) is endemic. In Stevens' study, the children were divided into three approximately equal groups and given hepatitis B vaccine according to three different protocols. The first group received the first of three standard 10-μg childhood doses at 6 months of age; a second group began the series at 3 months of age; and the third group within one week of birth. After receiving three doses of the vaccine, more than 90% of the children responded with substantial amounts of hepatitis B antibody. These results allay the concern that infants may not respond
ILLUSTRATIONS OF THE PATHOLOGY OF CANCER
Authors: J. Z. Laurence
Journal: BMJ (1856)

CANrCERLMR. PAGET states that, in 160 cancerous patients, there were 26, or very nearly one-sixth, who were aware of cancer in other members of their families.*M. Lebert, that " he sought with much care for hereditary predisposition in 102 cases, and found it in 14 of these patients.tIn 54
局灶性真皮发育不全女性中的嵌合现象
Authors: L. Heinz, E. Bourrat, P. Vabres, J. Thevenon, A. Hotz, S. Hörer, J. Küsel, A.D. Zimmer, S. Alter, R. Happle, J. Fischer
Journal: British Journal of Dermatology (2019)

这份来自德国和法国的报告描述了 4 名局灶性真皮发育不全 (FDH) 女性,FDH 是一种影响皮肤、骨骼、牙齿和眼睛的遗传病。FDH 因位于 X 染色体的称为 PORCN 的突变(异常)基因导致。存在此突变基因的男性胚胎通常不能存活。女性更为复杂。首先,她们有两条 X 染色体,但对于发生 FDH,它只需要一条染色体上存在突变基因。其次,在妊娠后,所有胚胎细胞中两条染色体中的一条被随机失活。来自正常X 染色体的细胞系(姊妹细胞)处于正常的活化发育过程;而来自异常 X 染色体的细胞系由于该突变基因处于异常活化发育过程。这种现象被称为嵌合现象(并顺便解释了玳瑁猫为何总为雌性),在此现象中,个体的细胞系代表了不同的遗传群体。FDH 突变还常在授精后于发育的初期自发发生,但在 X 染色体失活之前。来自这一报告的主要信息是,人们不能单纯通过使用血液的标准遗传学检测来排除 FDH。在受影响的女性中,由于嵌合现象,其临床症状可能轻微,血液检查为阴性,但在她们的 X 染色体仍处于活化状态的携有此基因的皮肤细胞中仍可发现异常基因。重要的是,卵巢也可能包含此类细胞,这种情况下可将该病传递给孩子。
Alone
Authors: Frank DeCicco
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medicolegal.
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the Food and Drug administration
Authors: S. L. Nightingale
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early fluid resuscitation in severe trauma
Journal: BMJ (2012)

would like to point out that there are a few inaccuracies in their article.In the last line of the first paragraph, the parenthesis should have clarified that severe traumatic injuries are defined as >15 [not "<15"] by the injury severity score.The third paragraph under the heading "What fluids should be used to resuscitate trauma patients who do not need DCR?" should also have read, in its penultimate sentence: "Among patients with severe traumatic brain injury not in hypovolaemic shock, initial resuscitation with either hypertonic saline or hypertonic saline and dextran [not "or dextran"], compared with normal saline, did not result in improved neurological outcome or survival at six months."Lastly, reference 16 should have cited Bickell WH [not "Bicknell"] as the first author.
Sleep Deprivation and Performance of Residents
Authors: Dennis H. Novack
Journal: JAMA (1989)

<h3>To the Editor.—</h3> Deaconson and colleagues<sup>1</sup>concluded that their data did not support an assumption that sleep deprivation adversely effects the capacity of residents to exhibit the cognitive and motor functions needed to provide appropriate patient care. The authors, however, overlook some key points. Even if cognitive and motor function are preserved, other physician attributes such as judgment, compassion, and interpersonal skills are necessary for good patient care. Residents' comments at a recent house staff support meeting<sup>2</sup>reinforce these concerns. Residents expressed strong convictions that sleep deprivation adversely affects patient care. Many residents talked about different kinds of mistakes they had made that they ascribed to sleep deprivation: giving the wrong antibiotic, overlooking diagnoses, mistranscribing orders, and falling asleep while writing up a history (and sometimes continuing to write while inspired by a dream—one resident was surprised to find in the morning that he had written under his
Official Call
Authors: Donovan F. Ward, Milford O. Rouse, Raymond M. McKeown
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ultrasound breast scanning: (only) a complement to mammography?
Authors: B. Bolsen
Journal: JAMA (1982)

Five years ago, a nationwide breast cancer screening project using mammography was interrupted by a radiation scare. A handful of committees reviewed the project—an American Cancer Society (ACS) and National Cancer Institute-sponsored effort to pick up early, undetected cancers in women aged 35 to 74 years—and recommended against routine mammography for asymptomatic women younger than 50 years. The benefits of screening younger women do not outweigh the risks of causing a few additional breast cancers, the experts said. Since then, improvements in technology have cut the radiation dose in half—to less than 1 rad for a two-view study of the breast. Nevertheless, a lingering concern about radiation risk among some physicians and patients appears to be partially responsible for a boom in sales of breast ultrasound scanners after just a few years on the market. Although fewer than 100 are in place in the United States, the number is expected
Von Willebrand and tissue factors expressions increased in the atrial tissue of the fibrillating atrium Naab M. Al-Saady, A. J. Haven, Nidal Maarouf, Mark M. Gallagher, Peter O'Callaghan, Owen A. Obel, Andrew J. Murday, Michael J. Davies, A. John Camm. St. George's Hospital Medical School, London, United Kingdom
Journal: Journal of the American College of Cardiology (2001)
Contents page + Editorial Board
Authors: Alfonso Represa, Antonio Persico, Thomas Bourgeron, Monica Zilbovicius, Isabelle Meresse, Nadia Chabane, Francis Brunelle, Yves Samson, Nathalie Boddaert, Ghislaine Dehaene-Lambertz, Lucie Hertz-Pannier, Jessica Dubois, Michelle De Haan, Mortimer Mishkin, Torsten Baldeweg, Faraneh Vargha-Khadem, Paula Tallal, Nadine Gaab, Samuel Berkovic, John Mulley, Ingrid Scheffer, Steven Petrou, Anthony Van Den Pol, Rustem Khazipov, Heiko Luhmann, Michel Le Van Quyen, Ilgam Khalilov, Yehezkel Ben, Ari Trendsin, Sian Lewis, Heather Brown, Patrick Liu, Manager Moulton, Guy Orban, Peter Janssen, Rufin Vogels
Journal: Trends in Neurosciences (2006)
What's new in the other general journals
Authors: K. Fister
Journal: BMJ (2006)

An estimated 16% of adults in Zambia are infected with HIV. In the Zambian capital Lusaka 22% of adults are infected. In 2004 the Zambian government started a programme of delivering antiretroviral treatment to people in need. Previously, the treatment had been available through private insurance only. The programme depends largely on primary care practices and nurses, and on non-physician clinical officers. Credit: JAMA In the first year and a half of the programme, more than 20 000 adults were enrolled into care and about three quarters of them received antiretroviral treatment. With high rates of uptake and adherence and a good response to treatment, the programme seems feasible and continues to expand delivery of care. By April 2006 it enrolled nearly 40 000 people infected with HIV. Credit: ANN INTERN MED In Kenya, about 9% of adults are infected with HIV, but three quarters of adults do not know their HIV status. In 2000, there were only three centres where people could get a test. Since then, the provision and use of voluntary HIV counselling and testing has expanded rapidly: by the end of 2005 there were nearly 700 centres countrywide. Research has shown that voluntary counselling and testing reduces risky health behaviour. JAMA 2006;296: 782–93, 296:855-8 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Preventing transmission of HIV from infected mothers to their newborns in Africa needs to balance the benefits of breast feeding against the risk of HIV transmission. A trial in Botswana randomised 1200 women and their newborns to formula feeding and one month of zidovudine or exclusive breast feeding and six months of zidovudine. At seven months, significantly fewer babies randomised to formula were infected with HIV (5.6% v 9.0%, respectively; P = 0.04), but mortality was lower in the group randomised to breast feeding (9.3% v 4.9%; P = 0.003). At … [1]: {openurl}?query=rft.jtitle%253DJAMA%26rft.stitle%253DJAMA%26rft.issn%253D0002-9955%26rft.aulast%253DStringer%26rft.auinit1%253DJ.%2BS.%2BA.%26rft.volume%253D296%26rft.issue%253D7%26rft.spage%253D782%26rft.epage%253D793%26rft.atitle%253DRapid%2Bscale-up%2Bof%2Bantiretroviral%2Btherapy%2Bat%2Bprimary%2Bcare%2Bsites%2Bin%2BZambia%253A%2Bfeasibility%2Band%2Bearly%2Boutcomes.%26rft_id%253Dinfo%253Adoi%252F10.1001%252Fjama.296.7.782%26rft_id%253Dinfo%253Apmid%252F16905784%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1001/jama.296.7.782&link_type=DOI [3]: /lookup/external-ref?access_num=16905784&link_type=MED&atom=%2Fbmj%2F333%2F7565%2F437.atom [4]: /lookup/external-ref?access_num=000239763400019&link_type=ISI