tbuckley/cabot-search huggingface dataset:
A Reference Hand-Book FOR Nurses.
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tuberculosis Outbreak in an Alabama High School
Authors: Philip D. Darney
Journal: JAMA (1971)

The diagnosis of clinical tuberculosis in a student at an Alabama high school in March 1969 prompted skin testing of 379 students and 147 additional contacts. The skin positivity rate among the students was 77% and seven additional clinical cases were uncovered. In May 1969 seventeen students who had initially had negative or doubtful reactions had converted, but no new clinical cases were found. In October 1969 four new reactors (1.7%) among students who had attended the implicated school during the previous school year were found.
Rationale and benefit of preoperative irradiation in lung cancer
Authors: F. G. Bloedorn
Journal: JAMA (1966)

If we were to summarize the experience of the treatment of cancer by means of either surgery or radiotherapy alone, we would say that surgery is efficient in controlling the accessible localized tumors, especially if they are histologically welldifferentiated; irradiation will control tumors of the radiosensitive type when a cancerocidal dose of irradiation can be delivered to the whole tumorbearing area without destroying the normal tissues. Both surgery and radiation are fraught with many failures in controlling advanced stages of cancer, even when there is a favorable set of circumstances. This is the basis for the need of combined therapies in the treatment of cancer. In determining a policy of treatment of cancer, there are two fundamental concepts to consider: (1) the natural history of the cancer and (2) the cancer-host relationship in each particular case. These two sets of circumstances will determine the local and systemic aggressivity of a
Doctor, help! My child has cancer
Authors: C. Essex
Journal: BMJ (2000)

The sexual health of boys and men Commercial advertisements are needed to create a condom cultureEditor-Yamey highlighted the need for work on the sexual health of boys and men, and he identified education and service provision as the key factors in increasing condom use, among other outcomes. 1Both of these factors fail to address the underlying problem, that condoms are unpopularthey are far short of desired items among young men in particular.A major factor influencing cultural attitudes is not education or services but the media.Global marketing, vast advertising budgets, and sexual imagery are used to sell items as diverse as chocolate bars and sanitary products on television.However, noticeably absent in the United Kingdom is any commercial television advertisement promoting particular condom brands or targeted to the growing market for condoms.Consequently, the promotion of condom use falls largely on public sector bodies.Education and health bodies have already made condoms more available to young people and developed an understanding of their health benefits.However, without a cultural move making condom use popular, such efforts have limited success as health promotion fights to convince people to use unpopular products.Partly as a result, sexually transmitted infections in young people are increasing in England, 2 and there are 90 000 teenage conceptions a year. 3ondoms are produced commercially and lend themselves to many images that are used to market other products successfully, so you would predict a deluge of television adverts promoting one brand above another.Antiquated advertising rules may explain why this has not happened.Those governing condom advertisements on UK television expressly forbid companies from showing the product unwrapped, and consequently the image of an unwrapped condom cannot be normalised or promoted. 4Advertising limitations also dictate social responsibility in advertisements and prohibit anything promoting promiscuity.How far these other measures limit advertisers seems to be unknown, but such restrictions should be measured against the numerous television hours showing promiscuity without any reference to condoms.Furthermore, these considerable restrictions on condom advertising may prevent movement of new producers into markets and consequently stifle the competition necessary to refine marketing and product development.The government is pursuing strategies in communicable disease, sexual health, and HIV, as well as reductions in teenage pregnancy. 3Pragmatic revisions to existing rules on the commercial advertising of condoms may allow commercial interests to work with those of health to alter the image of condoms and increase markets (particularly among young people) in order to help reduce sexually transmitted infections and unwanted pregnancies.
Studies on the Pathogenesis of Simian Adenovirus-Induced Tumors. III. The Histopathology and Ultrastructure of Intracranial Neoplasms Induced bv SV20&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Leonard Merkow, Malcolm Slifkin, Matias Pardo, Norbert P. Rapoza
Journal: JNCI Journal of the National Cancer Institute (1968)

In newborn hamsters, the simian adenovirus 20 (SV20), when administered intracerebrally, induces undifferentiated intracranial neoplasms. Histologically, these viral-induced neoplasms are diffuse, and although most of the tumor cells are mononuclear, occasional multinucleated forms are present. Examination of the ultrastructure of both multinuclear and mononuclear tumor cells revealed virus-like particles resembling infectious SV20 multiplying in vitro.in LLC-MK2 cells. These virus-like particles were noted in both the cytoplasm and nucleus of the intracranial tumor cells. An interrelationship between stacks of cisternal smooth endoplasmic reticulum, annulate lamellae, and the nuclear envelope was also observed in the neoplastic cells. Characteristic changes in the cisternae of the smooth endoplasmic reticulum appear to result in the formation of annulate lamellae. This process is similar but not identical to cytoplasmic vesicles “blebbed off” from the external membrane of the nuclear envelope. Thus this type of viral-induced neoplasm appears to be of interest for the study of oncogenesis and the origin of annulate lamellae.
Highlights of This Issue
Journal: Clinical Cancer Research (2013)

To assess the utility of cell-based models in cancer pharmacogenomic biomarker discovery, Wheeler and colleagues compared genome-wide association study results of paclitaxel-induced cytotoxicity in lymphoblastoid cell lines (LCL) and paclitaxel-induced peripheral neuropathy in breast cancer patients. Significant overlap between the clinical and LCL studies was observed, confirming a role for the LCL model in the analysis of a subset of genes involved in patient paclitaxel-induced toxicity. One overlap gene, RFX2, was functionally validated in a nerve cell model of paclitaxel response. These results are consistent with an underlying polygenic architecture for paclitaxel-induced toxicity and inform future studies of related phenotypes.Toll-like receptors (TLR) that recognize microbial components and trigger innate immune responses are expressed by chronic lymphocytic leukemia (CLL) cells. Fonte and colleagues asked if TLR stimulation might modulate the leukemic cell response to therapy. In vitro, different TLR ligands protected CLL cells from drug-induced cell death in a sizable proportion of cases. The molecular pathways involved include distinct molecules such as lymphotoxin and mir-155-3p. Hence, leukemic cell drug sensitivity may be modulated in vitro by TLR stimulation, likely mirroring the in vivo influence of microenvironmental signals. Lymphotoxin and mir-155-3p warrant further validation as markers of chemoresistance.The achievement of complete tumor remission is the ultimate goal of cancer therapy. Kim and colleagues utilized engineered mesenchymal stem cells coexpressing dodecameric TRAIL (dTRAIL) and HSV-TK (MSC/dTRAIL-TK) and showed combinatory antitumor activities of dTRAIL and HSV-TK/ganciclovir (GCV) in an experimental metastasis model of renal cell carcinoma. In addition, MSC/dTRAIL-TK was preferentially located in the vicinity of tumor nodule sites within the lung tissue of metastatic tumor-bearing mice. Most importantly, triple administration of MSC/dTRAIL-TK with GCV could exhibit 100% survival. These findings provide a promising therapeutic strategy for complete cure of metastatic tumor by simple, repeated injection of MSC/dTRAIL-TK.Defining appropriate dosing regimens for anticancer drugs in children represents a major challenge. Veal and colleagues show how an adaptive dosing approach can be successfully utilized to reduce interpatient variability in 13-cis-retinoic acid exposure in neuroblastoma patients. The study revealed that reduced body weight–based dosing should not be implemented for children &lt;12 kg and that increased doses may be beneficial for children unable to swallow 13-cis-retinoic acid capsules, a group representing the majority of high-risk neuroblastoma patients. The findings highlight the importance of using drugs optimally in poor prognosis tumor types and the need for appropriate drug formulations for all patients.
THE ETIOLOGY OF ACUTE ARTICULAR RHEUMATISM.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blood Coagulation Simplified
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chronic Granulomatous Disease in Three Female Siblings
Authors: Parvin H. Azimi
Journal: JAMA (1968)

Three female siblings aged 6, 4, and 2 years with the clinical syndrome of chronic granulomatous disease had frequent hospital admissions for serious bacterial infections, including pneumonia, liver abscesses, pyoderma, keratoconjunctivitis, draining adenitis, septicemia, and anemia. All three children were immunologically competent. Liver biopsy specimens in two of the three showed "chronic granulomatous reaction." Polymorphonuclear leukocytes from the patients showed impaired bactericidal ability when incubated with<i>Staphylococcus aureus</i>. Their leukocytes showed decreased ability to reduce nitroblue tetrazolium (NBT) dye compared with normal cells. The X-linked mode of transmission found in males with fatal chronic granulomatous disease is unlikely in these cases even if the Lyon hypothesis is considered. An autosomal locus acting either as homozygous recessive or dominant with variable expression would explain the occurrence of this disorder in females.
Issue Information ‐ General Info
Journal: Arthritis & Rheumatology (2022)

Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have focused on sharing our content with those in need, enhancing community philanthropy, reducing our carbon impact, creating global guidelines and best practices for paper use, establishing a vendor code of ethics, and engaging our colleagues and other stakeholders in our eff orts.Follow our progress at www.
Appearance of Collagen Proline Hydroxylase in Sera of Mice With Implanted Sarcomas
Authors: Nelson E. Roberts, Sidney Udenfriend
Journal: JNCI Journal of the National Cancer Institute (1970)

A number of solid tumors were shown to have relatively high contents of collagen proline hydroxylase, one of the enzymes involved in collagen biosynthesis. Tumor tissue from three mouse sarcomas—fibrosarcoma SaD2, rhabdomyosarcoma BW10139, and chondrosarcoma DC II—attained high enzyme levels. Coincident with the increase in the activity of collagen proline hydroxylase in the tumors, the enzyme increased in the serum of the host animals. Should suitable methods be developed, appearance in the serum of this normally intracellular enzyme may prove useful in the diagnosis of certain collagen-forming tumors and other collagen disorders in man.
Rhesus sensitization and abortion.
Authors: E A Normington, R F Jennison
Journal: BMJ (1969)

Cyclone over Cyclamates SIR,-In your leading article (1 November, p. 251) you point out that the decision to ban the manufacture of cyclamates has been taken without evidence that they cause disease in man, whereas the production of cigarettes, which are known to be highly dangerous, is less severely censored.A curtailed consumption of cyclamates lnight well lead to a compensatory increase i-i the consumption of sugar, for which they are a substitute.Whereas cyclamates have produced no proved ill-effects in man, exces- sive sugar consumption is believed by many to be a major factor in the causation of much disease, including diabetes,`13 coronary dis- ease,35 dental caries,6 and obesity.Almost anything taken in gross excess is harmful.Would the replacement of cyclamates by sugar not be tantamount to recommending a therapeutic procedure carrying a 10% mortality to treat a disease having a 1 %/b mortality ?-I am, etc.,
France plans compulsory treatment of sex offenders
Authors: A. Dorozynski
Journal: BMJ (1997)

A cross section of amygdaloidal spilitic lava was examined by optical and chemical methods in order to determine systematically the variation in soda content from margin to core. The soda content is lowest at the margin, reaches a maximum about 2 cm. inside the margin, and decreases slightly thereafter to the center. This distribution can be explained in terms of diffusion during crystallization.
THE PATHOLOGY OF AVITAMINOSIS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Shaking Palsy 1817-1967
Authors: David J. LaFia
Journal: JAMA (1967)

<h3>To the Editor:—</h3> The year 1967 will mark the 150th anniversary of the publication of James Parkinson's famous essay, "The Shaking Palsy," in which in vivid terms he fully documented the disease. This essay caught the attention of Charcot, who referred to patients with paralysis agitans as having "la maladie de Parkinson." Thus Charcot gave the name "Parkinson's disease." It was not until after the 1917 and 1918 epidemics of encephalitis that the syndrome of rigidity, tremor, oculogyric crises, and drooling assumed greater significance. Following this period, the journals were filled with articles on postencephalitic Parkinson's disease. The connection with encephalitis became so well entrenched that many neurologists believed that Parkinson's disease would disappear once the effects of the encephalitis epidemic were dissipated. Instead, in the subsequent decades, more and more cases were recognized. It became evident that there was a type of Parkinson's disease that was connected neither with
Antepartum risk factors for newborn encephalopathy
Authors: M. Ellis, A. M d. L Costello, D. J Murphy, N. Badawi, J. J Kurinczuk, F. J Stanley, J. M Keogh, P. R Burton
Journal: BMJ (1999)

Proportions of cases (babies with neonatal encephalopathy) and controls having complicated* and uncomplicated † deliveries in Badawi et al's study No (%) of cases (n=164) No (%) of controls (n=400) Unadjusted odds ratio (95% CI) Complicated delivery 79 (48) 101 (25) 2.75 (1.88 to 4.02) Uncomplicated delivery 85 (52) 299 (75) 0.36 (0.25 to 0.53) *Complicated deliveries: instrumental deliveries
The Autonomic Nervous System: Anatomy, Physiology and Surgical Application
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Story of the Johns Hopkins: Four Great Doctors and the Medical School They Created
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of proliferative haemangiomas with the 585nm pulsed dye laser
Authors: R.J. BARLOW, N.P.J. WALKER, A.C. MARKEY
Journal: British Journal of Dermatology (1996)

Journal Article Treatment of proliferative haemangiomas with the 585nm pulsed dye laser Get access R.J. BARLOW, R.J. BARLOW Dermatological Surgery and laser Unit st john's institute of dermatology, St Thomas Hospital, London U.K. Search for other works by this author on: Oxford Academic Google Scholar N.P.J. WALKER, N.P.J. WALKER Dermatological Surgery and laser Unit st john's institute of dermatology, St Thomas Hospital, London U.K. Search for other works by this author on: Oxford Academic Google Scholar A.C. MARKEY A.C. MARKEY Dermatological Surgery and laser Unit st john's institute of dermatology, St Thomas Hospital, London U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 134, Issue 4, 1 April 1996, Pages 700–704, https://doi.org/10.1046/j.1365-2133.1996.80842.x Published: 01 April 1996 Article history Accepted: 20 June 1995 Published: 01 April 1996