tbuckley/cabot-search huggingface dataset:
Type 2 Diabetes — Controlling the Epidemic, Episode 1: Understanding and Preventing Type 2 Diabetes
Authors: E. Dale Abel, Jessica Giffin, Julie R. Ingelfinger, Monica Peek, Jane E.B. Reusch, Clifford J. Rosen, Amy Sagendorf, Edwin Thomas
Journal: New England Journal of Medicine (2023)

In this first episode of "Type 2 Diabetes — Controlling the Epidemic," a four-part Double Take video miniseries from the New England Journal of Medicine, Drs. Jane E.B. Reusch (University of Colorado), E. Dale Abel (UCLA), and Monica Peek (University of Chicago) discuss the pathophysiology of the disease and its common complications. The experts also review prediabetes and the importance of engaging at-risk communities for diabetes screening and prevention. For further reading, the following articles, referenced in this video as among the first studies to demonstrate that lifestyle changes could prevent or forestall type 2 diabetes, are available on the Journal's website: Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance (Tuomilehto et al., in the May 3, 2001, issue) and Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin (Diabetes Prevention Program Research Group, in the February 7, 2002, issue).
Conceptualizations of wellbeing among nonbinary individuals in the Midwestern United States: a photovoice study
Authors: M. Killian Kinney, Bryan G. Victor, J. Dennis Fortenberry
Journal: International Journal of Transgender Health (2023)

Traditionally, gender has been viewed through an essentialist lens with fixed biology-based traits or polarized gender norms between women and men. As awareness of gender diversity grows, increasingly more people are coming out as nonbinary - or not exclusively a man or woman. Little has been explored regarding experiences unique to nonbinary individuals, particularly beyond a focus on adverse risks and outcomes to understand their wellbeing. This article discusses gendered experiences and the construction of wellbeing among nonbinary individuals.
Multifunctional nanocomposites modulating the tumor microenvironment for enhanced cancer immunotherapy
Authors: Prashant Sharma, Mario Otto
Journal: Bioactive Materials (2023)

Cancer immunotherapy has gained momentum for treating malignant tumors over the past decade. Checkpoint blockade and chimeric antigen receptor cell therapy (CAR-T) have shown considerable potency against liquid and solid cancers. However, the tumor microenvironment (TME) is highly immunosuppressive and hampers the effect of currently available cancer immunotherapies on overall treatment outcomes. Advancements in the design and engineering of nanomaterials have opened new avenues to modulate the TME. Progress in the current nanocomposite technology can overcome immunosuppression and trigger robust immunotherapeutic responses by integrating synergistic functions of different molecules. We will review recent advancements in nanomedical applications and discuss specifically designed nanocomposites modulating the TME for cancer immunotherapy. In addition, we provide information on the current landscape of clinical-stage nanocomposites for cancer immunotherapy.
Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes
Authors: Joel S. Parker, Michael Mullins, Maggie C.U. Cheang, Samuel Leung, David Voduc, Tammi Vickery, Sherri Davies, Christiane Fauron, Xiaping He, Zhiyuan Hu, John F. Quackenbush, Inge J. Stijleman, Juan Palazzo, J.S. Marron, Andrew B. Nobel, Elaine Mardis, Torsten O. Nielsen, Matthew J. Ellis, Charles M. Perou, Philip S. Bernard
Journal: Journal of Clinical Oncology (2023)

To improve on current standards for breast cancer prognosis and prediction of chemotherapy benefit by developing a risk model that incorporates the gene expression-based "intrinsic" subtypes luminal A, luminal B, HER2-enriched, and basal-like.
BRAFV600E promotes DC3/monocyte differentiation in human gene-engineered HSPCs and causes multisystem histiocytosis
Authors: Tommaso Sconocchia, Johannes Foßelteder, Lisa Auinger, Erdem Özkaya, Theresa Benezeder, Magdalena Lang, Christine Beham-Schmid, Gerald Hoefler, Armin Zebisch, Albert Wölfler, Heinz Sill, Peter Wolf, Herbert Strobl, Andreas Reinisch
Journal: Leukemia (2023)
Author Correction: Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis
Authors: Alexandre Jourdon, Feinan Wu, Jessica Mariani, Davide Capauto, Scott Norton, Livia Tomasini, Anahita Amiri, Milovan Suvakov, Jeremy D. Schreiner, Yeongjun Jang, Arijit Panda, Cindy Khanh Nguyen, Elise M. Cummings, Gloria Han, Kelly Powell, Anna Szekely, James C. McPartland, Kevin Pelphrey, Katarzyna Chawarska, Pamela Ventola, Alexej Abyzov, Flora M. Vaccarino
Journal: Nature Neuroscience (2023)
Clinically conserved genomic subtypes of gastric adenocarcinoma
Authors: Yun Seong Jeong, Young-Gyu Eun, Sung Hwan Lee, Sang-Hee Kang, Sun Young Yim, Eui Hyun Kim, Joo Kyung Noh, Bo Hwa Sohn, Seon Rang Woo, Moonkyoo Kong, Deok Hwa Nam, Hee-Jin Jang, Hyun-Sung Lee, Shumei Song, Sang Cheul Oh, Jeeyun Lee, Jaffer A. Ajani, Ju-Seog Lee
Journal: Molecular Cancer (2023)

Gastric adenocarcinoma (GAC) is a lethal disease characterized by genomic and clinical heterogeneity. By integrating 8 previously established genomic signatures for GAC subtypes, we identified 6 clinically and molecularly distinct genomic consensus subtypes (CGSs). CGS1 have the poorest prognosis, very high stem cell characteristics, and high IGF1 expression, but low genomic alterations. CGS2 is enriched with canonical epithelial gene expression. CGS3 and CGS4 have high copy number alterations and low immune reactivity. However, CGS3 and CGS4 differ in that CGS3 has high HER2 activation, while CGS4 has high SALL4 and KRAS activation. CGS5 has the high mutation burden and moderately high immune reactivity that are characteristic of microsatellite instable tumors. Most CGS6 tumors are positive for Epstein Barr virus and show extremely high levels of methylation and high immune reactivity. In a systematic analysis of genomic and proteomic data, we estimated the potential response rate of each consensus subtype to standard and experimental treatments such as radiation therapy, targeted therapy, and immunotherapy. Interestingly, CGS3 was significantly associated with a benefit from chemoradiation therapy owing to its high basal level of ferroptosis. In addition, we also identified potential therapeutic targets for each consensus subtype. Thus, the consensus subtypes produced a robust classification and provide for additional characterizations for subtype-based customized interventions.
Highlighted research articles
Journal: Cancer Discovery (2023)

In This Issue| September 06 2023 Highlighted research articles Author & Article Information Online ISSN: 2159-8290 Print ISSN: 2159-8274 ©2023 American Association for Cancer Research2023American Association for Cancer Research Cancer Discov (2023) 13 (9): 1949–1951. https://doi.org/10.1158/2159-8290.CD-13-9-ITI Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record September 6 2023 Citation Highlighted research articles. Cancer Discov 1 September 2023; 13 (9): 1949–1951. https://doi.org/10.1158/2159-8290.CD-13-9-ITI Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Traditional chimeric antigen receptor (CAR) T-cell manufacturing requires extended ex vivo cell culture that reduces stem cell memory T cells and antitumor activity. In this study, Dickinson and colleagues assessed the preclinical development and the initial clinical evaluation of YTB323, an autologous CD19-directed CAR T-cell therapy that is manufactured using a next-generation process in less than 2 days. Use of YTB323 in preclinical mouse models demonstrated enhanced in vivo expansion and antitumor activity at lower doses than traditionally manufactured CAR T cells, while, in adults with relapsed/refractory diffuse large B-cell lymphoma, YTB323 showed promising safety and clinical activity at a 25-fold lower dose than tisagenlecleucel. See article, p. 1982. The clinical benefit generated by FGFR inhibition in patients with FGFR-driven urothelial cancer is mitigated by the onset of resistance. Facchinetti and colleagues performed sequencing analyses on postprogression tissue biopsies and circulating tumor DNA from 21 patients with FGFR... You do not currently have access to this content.
Platelet Count and Platelet Volume in Patients with CKD
Authors: Otis M. Davis, Rajshekhar Kore, Alexandra Moore, Jerry Ware, Jawahar L. Mehta, John M. Arthur, Donald R. Lynch, Nishank Jain
Journal: Journal of the American Society of Nephrology (2023)

Davis, Otis M BS; Kore, Rajshekhar PhD; Moore, Alexandra BS; Ware, Jerry PhD; Mehta, Jawahar L MD, PhD; Arthur, John M MD, PhD; Lynch, Donald R MD, MSCI; Jain, Nishank MD, MPH Author Information
Host functional traits as the nexus for multilevel infection patterns
Authors: Zheng Y.X. Huang, Fletcher W. Halliday, Daniel J. Becker
Journal: Trends in Ecology & Evolution (2023)

Understanding pathogen transmission and infection patterns at multiple biological scales is a central issue in disease ecology and evolution. Here, we suggest that functional traits of host species readily affect infection patterns of species, communities, and landscapes, and thus serve as a linkage for multilevel studies of infectious disease.
The neuropathogenesis of highly pathogenic avian influenza H5Nx viruses in mammalian species including humans
Authors: Lisa Bauer, Feline F.W. Benavides, Edwin J.B. Veldhuis Kroeze, Emmie de Wit, Debby van Riel
Journal: Trends in Neurosciences (2023)

Circulation of highly pathogenic avian influenza (HPAI) H5Nx viruses of the A/Goose/Guangdong/1/96 lineage in birds regularly causes infections of mammals, including humans. In many mammalian species, infections are associated with severe neurological disease, a unique feature of HPAI H5Nx viruses compared with other influenza A viruses. Here, we provide an overview of the neuropathogenesis of HPAI H5Nx virus infection in mammals, centered on three aspects: neuroinvasion, neurotropism, and neurovirulence. We focus on in vitro studies, as well as studies on naturally or experimentally infected mammals. Additionally, we discuss the contribution of viral factors to the neuropathogenesis of HPAI H5Nx virus infections and the efficacy of intervention strategies to prevent neuroinvasion or the development of neurological disease.
Prospective evaluation of genome sequencing to compare conventional cytogenetics in acute myeloid leukemia
Authors: Beth A. Pitel, Cinthya Zepeda-Mendoza, Zohar Sachs, Hongwei Tang, Suganti Shivaram, Neeraj Sharma, James B. Smadbeck, Stephanie A. Smoley, Kathryn E. Pearce, Ivy M. Luoma, Joselle Cook, Mark R. Litzow, Nicole L. Hoppman, David Viswanatha, Xinjie Xu, Rhett P. Ketterling, Patricia T. Greipp, Jess F. Peterson, Linda B. Baughn
Journal: Blood Cancer Journal (2023)
CAR virus receptor mediates erythroid differentiation and migration and is downregulated in MDS
Authors: Karin Bauer, Sigrid Machherndl-Spandl, Lukas Kazianka, Irina Sadovnik, Sinan Gültekin, Susanne Suessner, Johannes Proell, Jeroen Lauf, Gregor Hoermann, Gregor Eisenwort, Norman Häfner, Mathilde Födermayr-Mayrleitner, Ann-Sofie Schmolke, Emiel van der Kouwe, Uwe Platzbecker, Thomas Lion, Ansgar Weltermann, Otto Zach, Gerald Webersinke, Ulrich Germing, Christian Gabriel, Wolfgang R. Sperr, Marie C. Béné, Philipp B. Staber, Peter Bettelheim, Peter Valent
Journal: Leukemia (2023)
A globally integrated structure of taxonomy to support biodiversity science and conservation
Authors: Emily L. Sandall, Aurore A. Maureaud, Robert Guralnick, Melodie A. McGeoch, Yanina V. Sica, Matthew S. Rogan, Douglas B. Booher, Robert Edwards, Nico Franz, Kate Ingenloff, Maisha Lucas, Charles J. Marsh, Jennifer McGowan, Stefan Pinkert, Ajay Ranipeta, Peter Uetz, John Wieczorek, Walter Jetz
Journal: Trends in Ecology & Evolution (2023)

All aspects of biodiversity research, from taxonomy to conservation, rely on data associated with species names. Effective integration of names across multiple fields is paramount and depends on the coordination and organization of taxonomic data. We assess current efforts and find that even key applications for well-studied taxa still lack commonality in taxonomic information required for integration. We identify essential taxonomic elements from our interoperability assessment to support improved access and integration of taxonomic data. A stronger focus on these elements has the potential to involve taxonomic communities in biodiversity science and overcome broken linkages currently limiting research capacity. We encourage a community effort to democratize taxonomic expertise and language in order to facilitate maximum interoperability and integration.
Subcortical implantation of a passive microchip in rodents – an observational proof-of-concept study
Authors: Stephanie L. Plummer, Arjang Ahmadpour, John McDaid, Joseph Mark, John M. Lee, Vimal Patel, Julian E. Bailes
Journal: Brain-Computer Interfaces (2023)

The use of brain-computer interface (BCI) technologies is a rapidly developing area of interest in neurosurgery. Studies investigating the use of BCIs have primarily focused on surface electrodes; however, subcortically implanted microchips may provide novel, non-pharmacological approaches for managing nervous system disorders. Accessing subcortical regions without disrupting surrounding tissues remains a significant challenge. Accordingly, we conducted an observational, proof-of-concept study to evaluate the use of a modified BrainPath® device to implant subcortical microchips in a rodent model. All animals survived the procedure and lived with a microchip in situ for one or three months with no apparent neurological effects. Histological examination revealed that implantation of a small chip was associated with some tissue damage, tract formation, and surrounding reactive changes. Gliosis and hemosiderin-laden macrophages were evident surrounding tract marks after one month and focal cystic cavitation consistent with infarcted tissue was evident after three months. While a more extensive cellular proliferation response was apparent one month after implantation of a large microchip, there was no significant collagen deposition suggestive of fibrosis. This study is the first demonstration of subcortical microchip implantation using a novel neurosurgical technique that may facilitate the development of BCI technologies for treatment of neurological disorders.
Author Correction: Universal DNA methylation age across mammalian tissues
Authors: A. T. Lu, Z. Fei, A. Haghani, T. R. Robeck, J. A. Zoller, C. Z. Li, R. Lowe, Q. Yan, J. Zhang, H. Vu, J. Ablaeva, V. A. Acosta-Rodriguez, D. M. Adams, J. Almunia, A. Aloysius, R. Ardehali, A. Arneson, C. S. Baker, G. Banks, K. Belov, N. C. Bennett, P. Black, D. T. Blumstein, E. K. Bors, C. E. Breeze, R. T. Brooke, J. L. Brown, G. G. Carter, A. Caulton, J. M. Cavin, L. Chakrabarti, I. Chatzistamou, H. Chen, K. Cheng, P. Chiavellini, O. W. Choi, S. M. Clarke, L. N. Cooper, M. L. Cossette, J. Day, J. DeYoung, S. DiRocco, C. Dold, E. E. Ehmke, C. K. Emmons, S. Emmrich, E. Erbay, C. Erlacher-Reid, C. G. Faulkes, S. H. Ferguson, C. J. Finno, J. E. Flower, J. M. Gaillard, E. Garde, L. Gerber, V. N. Gladyshev, V. Gorbunova, R. G. Goya, M. J. Grant, C. B. Green, E. N. Hales, M. B. Hanson, D. W. Hart, M. Haulena, K. Herrick, A. N. Hogan, C. J. Hogg, T. A. Hore, T. Huang, J. C. Izpisua Belmonte, A. J. Jasinska, G. Jones, E. Jourdain, O. Kashpur, H. Katcher, E. Katsumata, V. Kaza, H. Kiaris, M. S. Kobor, P. Kordowitzki, W. R. Koski, M. Krützen, S. B. Kwon, B. Larison, S. G. Lee, M. Lehmann, J. F. Lemaitre, A. J. Levine, C. Li, X. Li, A. R. Lim, D. T. S. Lin, D. M. Lindemann, T. J. Little, N. Macoretta, D. Maddox, C. O. Matkin, J. A. Mattison, M. McClure, J. Mergl, J. J. Meudt, G. A. Montano, K. Mozhui, J. Munshi-South, A. Naderi, M. Nagy, P. Narayan, P. W. Nathanielsz, N. B. Nguyen, C. Niehrs, J. K. O’Brien, P. O’Tierney Ginn, D. T. Odom, A. G. Ophir, S. Osborn, E. A. Ostrander, K. M. Parsons, K. C. Paul, M. Pellegrini, K. J. Peters, A. B. Pedersen, J. L. Petersen, D. W. Pietersen, G. M. Pinho, J. Plassais, J. R. Poganik, N. A. Prado, P. Reddy, B. Rey, B. R. Ritz, J. Robbins, M. Rodriguez, J. Russell, E. Rydkina, L. L. Sailer, A. B. Salmon, A. Sanghavi, K. M. Schachtschneider, D. Schmitt, T. Schmitt, L. Schomacher, L. B. Schook, K. E. Sears, A. W. Seifert, A. Seluanov, A. B. A. Shafer, D. Shanmuganayagam, A. V. Shindyapina, M. Simmons, K. Singh, I. Sinha, J. Slone, R. G. Snell, E. Soltanmaohammadi, M. L. Spangler, M. C. Spriggs, L. Staggs, N. Stedman, K. J. Steinman, D. T. Stewart, V. J. Sugrue, B. Szladovits, J. S. Takahashi, M. Takasugi, E. C. Teeling, M. J. Thompson, B. Van Bonn, S. C. Vernes, D. Villar, H. V. Vinters, M. C. Wallingford, N. Wang, R. K. Wayne, G. S. Wilkinson, C. K. Williams, R. W. Williams, X. W. Yang, M. Yao, B. G. Young, B. Zhang, Z. Zhang, P. Zhao, Y. Zhao, W. Zhou, J. Zimmermann, J. Ernst, K. Raj, S. Horvath
Journal: Nature Aging (2023)
Enterococcus faecalis endocarditis risk assessment in patients with bacteremia: External validation of the DENOVA score
Authors: Pierre Danneels, Floris Chabrun, Léa Picard, Pauline Martinet, Schéhérazade Rezig, Aurélien Lorleac’h, Rodolphe Buzelé, Aurélie Beaudron, Marie Kempf, Gwenaël Le Moal, Matthieu Revest, David Boutoille, Adrien Lemaignen, Lucia Grandiere-Perez, Mathieu Nacher, Vincent Dubée
Journal: Journal of Infection (2023)
Vaccination in post-tuberculosis lung disease management: A review of the evidence
Authors: M.J. Nasiri, D.R. Silva, F. Rommasi, M.M. Zahmatkesh, Z. Tajabadi, F. Khelghati, T. Sarmastzadeh, R. Centis, L. D'Ambrosio, S. Bombarda, M.P. Dalcolmo, T. Galvão, F.C. de Queiroz Mello, M.F. Rabahi, E. Pontali, I. Solovic, M. Tadolini, L. Marconi, S. Tiberi, M. van den Boom, G. Sotgiu, G.B. Migliori
Journal: Pulmonology (2023)

Post-tuberculosis lung disease (PTLD), as other chronic respiratory disorders, may have infectious complications; some of them can be prevented with vaccinations. So far, no document has discussed the potential role of vaccination in PTLD. Therefore, the objective of this review was to describe vaccination recommendations to prevent infections potentially capable of complicating PTLD. A non-systematic review of the literature was conducted. The following keywords were used: tuberculosis, vaccination, vaccines and PTLD. PubMed/MEDLINE and Embase were used as the search engine, focusing on English-language literature only. We identified 9 vaccines potentially useful in PTLD. Influenza, pneumococcal and anti-COVID-19 vaccinations should be recommended. Patients with PTLD can also benefit from vaccination against shingles. Vaccination against pertussis is mainly relevant during childhood. Diphtheria, tetanus and measles vaccination are recommended for general population and should be considered in patients with PTLD not previously vaccinated. Tdap (Tetanus, diphtheria, and pertussis) booster should be repeated in every adult every ten years. Vaccination against BCG retains its importance during early childhood in countries where TB is endemic. Vaccination deserves to be considered among the strategies to prevent and/or mitigate PTLD complications. Further evidence is necessary to better understand which vaccines have the greatest impact and cost-benefit.
Being Breastfed in Infancy and Risk of Colorectal Cancer and Precursor Lesions
Authors: Chen Yuan, Qiao-Li Wang, Hanseul Kim, Ana Babic, Jinming Zhang, Brian M. Wolpin, Kana Wu, Mingyang Song, Shuji Ogino, Jeffrey A. Meyerhardt, Andrew T. Chan, Yin Cao, Edward L. Giovannucci, Kimmie Ng
Journal: Clinical Gastroenterology and Hepatology (2023)
Reliable population code for subjective economic value from heterogeneous neuronal signals in primate orbitofrontal cortex
Authors: Simone Ferrari-Toniolo, Wolfram Schultz
Journal: Neuron (2023)

Behavior-related neuronal signals often vary between neurons, which might reflect the unreliability of individual neurons or a truly heterogeneous code. This notion may also apply to economic ("value-based") choices and the underlying reward signals. Reward value is subjective and can be described by a nonlinearly weighted magnitude (utility) and probability. Defining subjective values relies on the continuity axiom, whose testing involves structured variations of a wide range of reward magnitudes and probabilities. Axiom compliance demonstrates understanding of the stimuli and the meaningful character of choices. Using these tests, we investigated the encoding of subjective economic value by neurons in a key economic-decision structure of the monkey brain, the orbitofrontal cortex (OFC). We found that individual neurons carry heterogeneous neuronal value signals that largely fail to match the animal's choices. However, neuronal population signals matched the animal's choices well, suggesting accurate subjective economic value encoding by a heterogeneous population of unreliable neurons.