AB1639 ASSOCIATION BETWEEN HYPERURICEMIA AND BONE MINERAL DENSITY WITH 8-YEAR FOLLOW-UP AMONG CHINESE ADULTS
Authors: J. Zeng, H. Liu, L. MA
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Hyperuricemia (HUA) have been associated with bone mineral density (BMD) in recent studies, especially for elderly men and peri- or postmenopausal women<sup>[1-3]</sup>. However, this association is still unknown for the long-term follow-up observation. <h3>Objectives</h3> This study investigated the relationship between hyperuricemia and bone mineral density at 8-year follow-up among Chinese adults. <h3>Methods</h3> The cohort study was collected at Guangdong Second Provincial General Hospital in Guangzhou City, China between January 2010 and December 2018. Physical examinations and laboratory measurement variables were obtained from the medical check-up system. The physical examination population was followed up annually for 8 years. Multivariate Cox proportion models was used to explore the relationship between the hyperuricemia and bone mineral density. <h3>Results</h3> In total, 9017 individuals were included (2620 HUA participants (39.6% female) at baseline with an average age of 44.85 years (SD: 12.35) and average BMD of -0.83 (SD:1.24). The BMD decreased annually at the 8-year follow-up (from -0.82 to -0.93). Compared with normal participants, the Cox regression analysis showed that hyperuricemia was significant associated with lower BMD(T&lt;-2.5) (hazards ratio (HR)=1.169, 95%CI: 1.059–1.290, P &lt;0.05), the male (HR=2.545,95%CI: 2.389–2.710, P &lt;0.05) and the elderly (age≥65) (HR=1.121,95%CI: 1.012–1.241, P &lt;0.05) at follow-up. <h3>Conclusion</h3> Our study observed participants with hyperuricemia had significantly lower BMD, especially for males and the elderly participants. More high-quality research is needed to further support these findings. <h3>References</h3> [1]Simon D, Haschka J, Muschitz C, Kocijan A, Baierl A, Kleyer A, et al. Bone microstructure and volumetric bone mineral density in patients with hyperuricemia with and without psoriasis. Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2020; 31:931-9. [2]Veronese N, Carraro S, Bano G, Trevisan C, Solmi M, Luchini C, et al. Hyperuricemia protects against low bone mineral density, osteoporosis and fractures: a systematic review and meta-analysis. European journal of clinical investigation. 2016; 46:920-30. [3]Zhang D, Bobulescu IA, Maalouf NM, Adams-Huet B, Poindexter J, Park S, et al. Relationship between serum uric Acid and bone mineral density in the general population and in rats with experimental hyperuricemia. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research. 2015; 30:992-9. <h3>Acknowledgements</h3> The study was supported by the Science Foundation of Guangdong Second Provincial General Hospital (YQ2019-008). <h3>Disclosure of Interests:</h3> <h3>None declared.</h3> <h3>Acknowledgements</h3> The study was supported by the Science Foundation of Guangdong Second Provincial General Hospital (YQ2019-008). <h3>Disclosure of Interests</h3> None Declared.