tbuckley/cabot-search huggingface dataset:
SURVEY OF LITERATURE
Journal: British Journal of Dermatology (1940)

British Journal of DermatologyVolume 52, Issue 12 p. 377-380 SURVEY OF LITERATURE First published: December 1940 https://doi.org/10.1111/j.1365-2133.1940.tb09901.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume52, Issue12December 1940Pages 377-380 RelatedInformation
Guidelines for Ethics Committees in Health Care Institutions
Authors: Judicial Council
Journal: JAMA (1985)

THESE guidelines have been developed to aid in the establishment and functioning of ethics committees in hospitals and other health care institutions that may choose to form such committees, recognizing that the functions may vary depending on the type of institution. Ethics committees in health care institutions should be voluntary, educational, and advisory in purpose so as not to interfere with the primary responsibility and relationship between physicians and their patients. Generally, the function of the ethics committee is to consider and assist in resolving unusual, complicated ethical problems involving issues that affect the care and treatment of patients within the health care institution and concern those persons who are responsible for their care and treatment. Typical are issues involving quality of life, terminal illness, and utilization of scarce, limited health resources. The size of the ethics committee should be consistent with the needs of the institution but not so
Toxoplasmic encephalitis in patients with acquired immune deficiency syndrome
Authors: B. J. Luft
Journal: JAMA (1984)

An epidemic of cases of toxoplasmic encephalitis is occurring in patients with acquired immune deficiency syndrome (AIDS). Serological or histopathologic studies were performed on 70 cases with AIDS and toxoplasmic encephalitis. In many cases conventional stains of brain-tissue specimens failed to disclose<i>Toxoplasma</i>organisms; all were positive when stained by the peroxidase-antiperoxidase technique. Except for a single patient, serological titers were not indicative of an acute acquired infection. The ratio of titers in the agglutination test to titers in the Sabin-Feldman dye test seemed to be more predictive of active toxoplasmic encephalitis in patients with AIDS than either test alone. Based on histological and serological data, an approach is presented for diagnosis and treatment of suspected toxoplasmic encephalitis in patients with AIDS. (<i>JAMA</i>1984;252:913-917)
Evidence of a Genetic Susceptibility Locus Influencing Interindividual Variation in Triglycerides: The NHLBI Family Heart Study
Authors: Donna K Arnett, Larry Atwood, Michael A Province, Hilary Coon, James Pankow
Journal: Circulation (2001)

P06 Genomic regions have been linked to hypertriglyceridemia associated with familial syndromes, such as familial combined hyperlipidemia. However, there is little information regarding chromosomal regions harboring susceptibility genes for more common forms of hypertriglyceridemia. Significant linkage of triglycerides (TGs) was recently identified on chromosome 15 in Mexican Americans (LOD=3.88). As part of the NHLBI-sponsored Family Heart Study (FHS), a genome-wide linkage analysis was done to replicate this finding or to identify other quantitative trait loci for TGs. Multi-generational families were recruited (a) at excess risk of early onset myocardial infarction and (b) randomly selected from Framingham, Atherosclerosis Risk in Communities, and Utah Family Tree Studies. The largest families were selected for genomic analysis (105 families, family size=8.6). Microsatellite markers (n=369), approximately equally spaced throughout the genome (CHLC-10), were typed by the NHLBI Mammalian Genotyping Service. TGs were measured in participants fasting for at least 12 hours. TGs were adjusted for sex, age and age 2 , and log-transformed to normalize the distribution. The search for quantitative trait loci for TGs was carried out using a multipoint model-free variance components method implemented in GENEHUNTER. The mean age was 60 years and 52% were female. The mean triglyceride value in the family members was 146 (±85) mg/dl in men and 155 (±102) mg/dl in women. Evidence for linkage was identified on chromosome 4 (LOD=3.23 (p&lt;.0003) at position 35cM from the pter). Further evidence for linkage was found on chromosome 15 (LOD=1.90 (p&lt;.007) at position 36cM from the pter), which overlaps the genomic region identified in Mexican Americans. In conclusion, we found significant evidence for linkage of TGs to a region on chromosome 4 in families either randomly recruited or at high risk of early onset coronary heart disease. This putative locus appears to have a major influence on the interindividual variation in triglycerides. Finally, these data add support for the existence of a putative locus for TGs on chromosome 15.
Nocardia pericarditis
Authors: A D Mackay, G M Scott, S L Cohen, E Stonehill
Journal: BMJ (1995)

and V and no significant decrease by men in socioeconomic group V or women in socioeconomic group III.Our data do not exclude the future impact of health publicity or, indeed, of a reduction or cessation in advertising on smoking by lower socioeconomic groups, and we think it important that there should be research into and evaluation of health promotion and advertising aimed at these groups.
Effect of Inhaling Heated Vapor on Symptoms of the Common Cold
Authors: Michael L. Macknin
Journal: JAMA (1990)

A double-blind, randomized study tested the efficacy of steam (technically, heated, humidified air) inhalation in the treatment of common cold symptoms. Two 20-minute treatments spaced 60 to 90 minutes apart were given at the time of enrollment. The active device (Rhinotherm, Netzer-Sereni, Beer Yaacov, Israel) delivered 40 L/min of saturated air at 40°C to 42°C, while the identical-appearing placebo delivered 2 L/min of ambient air at 20°C to 24°C. There were 34 patients in the placebo group and 32 in the active group. Significant improvements in the placebo-treated group were obtained on subjective symptom scores for nasal congestion, nasal drainage, and sneezing on isolated days during the treatment period (40% vs 25% on day 3, 71% vs 60% on day 6, and 100% vs 67% on day 7). Improvement in nasal resistance as measured by rhinomanography was better in the placebo group than in the active group on day 7 (11% vs—6%). Our study demonstrated no beneficial effects of steam inhalation on common cold symptoms. (<i>JAMA</i>. 1990;264:989-991)
PL3.2 Trabectedin for recurrent WHO grade II or III meningioma: a randomized phase II study of the EORTC Brain Tumor Group (EORTC-1320-BTG)
Authors: M Preusser, A Silvani, E Le Rhun, R Soffietti, G Lombardi, J Sepulveda, P Brandal, R Beaney, A Bonneville-Levard, V Lorgis, J Bromberg, S Erridge, A Cameron, C Marosi, V Golfinopoulos, T Gorlia, M Weller, W Wick
Journal: Neuro-Oncology (2019)

Abstract BACKGROUND EORTC-1320-BTG investigated the activity, safety and quality of life of therapy with the tetrahydroisoquinoline alkaloid trabectedin (Yondelis®) in patients with recurrent higher-grade meningiomas. Trabectedin was originally derived from the Caribbean sea squirt, Ecteinascidia turbinata, and currently is manufactured by total synthesis. METHODS Adult patients with histological diagnosis of WHO grade II or III meningioma and radiologically documented progression after maximal feasible surgery and radiotherapy were randomly assigned in a 2:1 ratio to receive intravenous trabectedin (1.5 mg/m2every three weeks) or local standard of care (LOC). The primary endpoint was progression-free survival (PFS). RESULTS Within 22.1 months, we randomized a total of 90 patients (n=29 in LOC arm, n=61 in trabectedin arm) in 35 institutions and nine countries. In the LOC arm, the following treatments were administered: hydroxyurea (n=11), bevacizumab (n=9), none (n=4), chemotherapy (n=3), somatostatin analogue (n=1), combined chemotherapy and somatostatin analogue (n=1). With 71 PFS events, median PFS was 4.17 months in the LOC and 2.43 months in the trabectedin arm (hazard ratio [HR] for progression, 1.42; 80% CI, 1.00–2.03; p=0.204) with a PFS-6 rate of 29.1% (95% CI, 11.9%-48.8%) in the LOC and 21.1% (95% CI, 11.3%-32.9%) in the trabectedin arm. Median OS was 10.61 months in the LOC and 11.37 months in the trabectedin arm (HR for death, 0.98; 95% CI, 0.54–1.76; p=0.94).Grade 3 to 5 adverse events occurred in 44.4% (18.5% related, 4 serious adverse events, 0 lethal events) of the patients in the LOC and 59% (32.8% related, 57 serious adverse events and 2 toxic deaths) of patient in the trabectedin arm. CONCLUSIONS In this first prospective randomized trial performed in recurrent grade II or III meningioma, trabectedin did not improve PFS and OS and was associated with significantly higher toxicity as compared to LOC treatment. The data collected in this study may serve as benchmark for future clinical trials in this setting.
The Appropriateness of Tympanostomy Tubes for Children
Authors: Jack L. Pulec
Journal: JAMA (1995)

<h3>To the Editor.</h3> —As the editor of a medical journal, I recognize the desirability to publish provocative and controversial articles. The article by Dr Kleinman and colleagues<sup>1</sup>involves a more significant issue. Before publication, articles in most medical journals are carefully reviewed by experts in the field being discussed to determine the scientific validity, statistical accuracy, and general worth of the communication. This article seems to be deficient on all counts. There is no evidence that any of the authors are trained to perform the procedure themselves nor did they personally collect the data. In addition, by their own admission, the information was obtained from the proprietary database maintained by a utilization review firm (VHS), a for-profit company listed on the New York Stock Exchange whose main interest is to restrict payment for medical care. As a member of the American Medical Association, I feel that it is outrageous
Osteoarthritis of the Knee and Hip after Joint Injury
Journal: Annals of Internal Medicine (2000)

Summaries for Patients5 September 2000Osteoarthritis of the Knee and Hip after Joint InjurySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-5-200009050-00001 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?In osteoarthritis, the cartilage of joints degenerates, making joint movement limited and painful. People with osteoarthritis report a history of joint injury more often than people without osteoarthritis. It is possible, however, that people with osteoarthritis may not actually have had previous joint injuries more often, but may simply remember them better than people without joint disease. The best way to determine whether injuries actually lead to later osteoarthritis is to record knee or hip injuries in a group of people at the time that they happen. You ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Joint Injury in Young Adults and Risk for Subsequent Knee and Hip Osteoarthritis.” It is in the 5 September 2000 issue of Annals of Internal Medicine (volume 133, pages 321-328). The authors are AC Gelber, MC Hochberg, LA Mead, N-Y Wang, FM Wigley, and MJ Klag.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoJoint Injury in Young Adults and Risk for Subsequent Knee and Hip Osteoarthritis Allan C. Gelber , Marc C. Hochberg , Lucy A. Mead , Nae-Yuh Wang , Fredrick M. Wigley , and Michael J. Klag Metrics 5 September 2000Volume 133, Issue 5Page: I-16KeywordsArthritisCartilageExerciseHipKneesMusclesOsteoarthritisQuestionnairesRisk managementYoung adults ePublished: 5 September 2000 Issue Published: 5 September 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Die Nephritiden und nichtentzündlichen Nierenerkrankungen:
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Authors: Mr Robert, V Cooke, Beau- Fort Vyvyan-Jones, Mrs Vyvyan-Jones, Mrs Lalonde, Rt Rev, Mrs Tomkins, Rt Tomkins, Clifton Rudder- Ham, J Harris, Mrs Harris, Mrs Rieger, Mrs Harrison, Robert Harrison, Mrs Twist, ; Alderman, Cyril Hebblethwaite, Denys Hicks, Lady Hicks, J Heller, Mrs Heller, C Powell, Mrs Powell, T Hewer, Mrs Hewer
Journal: BMJ (1967)
Radiologic features of diagnostic importance
Authors: R. H. Marshak
Journal: JAMA (1974)

ADENOCARCINOMA of the duodenum or small bowel is a rare lesion. Peripapillary carcinomas are usually polypoid, ulcerated, nonobstructive, and immediately adjacent to the papilla of Vater. In the remainder of the duodenum, primary carcinoma is difficult to distinguish from metastatic disease or extension of tumor from the pancreas. In the mesenteric small bowel, primary carcinoma occurs more frequently in the jejunum than in the ileum. The roentgenographic findings are usually a short, fairly sharply demarcated filling defect associated with an eccentric and irregular channel and with overhanging edges. The mucosa is ulcerated and partial obstruction is common.<sup>1</sup> In recent years, a number of cases of adenocarcinoma of the small bowel have been reported in association with long-standing regional enteritis or in surgically excluded loops.<sup>2</sup>The diagnosis is very difficult to establish preoperatively because the presence of multiple strictures with intervening segments of dilated bowel obscures the associated malignant
Medical education in the United States. 8. Special studies. Special studies in graduate medical education
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The management of preexcitation syndromes
Authors: H. J. Wellens
Journal: JAMA (1987)

The introduction of new techniques such as epicardial mapping and programmed stimulation of the heart has made it possible to unravel most of the mysteries surrounding ventricular preexcitation. They helped us to understand the mechanisms of the arrhythmias that frequently are found in these patients and led to better-directed therapeutic interventions. The purpose of this article is to review this information and to indicate how it can be used in the treatment of the patient with preexcitation. (<i>JAMA</i>1987;257:2325-2333)
Tissue Organ Distribution and Behavioral Effects of Platinum Following Acute and Repeated Exposure of the Mouse to Platinum Sulfate
Authors: Bradley A. Lown, John B. Morganti, Carl H. Stineman, Rosemary B. D'Agostino, Edward J. Massaro
Journal: Environmental Health Perspectives (1980)

Platinum sulfate was administered intragastrically (IG) to adult male Swiss mice in a single dose at the 7 day LD5 or LD25 level. Control groups received 0.25M H2SO4 (pH 0.85) or 0.14M NaCl. Open field behavior (ambulations, rearings) was measured, and tissue/organ Pt levels determined at 4 hr, or 1, 3, or 7 days post administration. At all times, the LD25 depressed ambulations significantly and rearings marginally. It did not effect exploratory ("hole-in-board") behavior. The LD25 resulted in disproportionately high tissue Pt levels relateive to the LD5. There were significant inverse correlations between behavior and tissue Pt levels for most tissues, but not for brain. In related experiments, adult male mice were subjected to repeated IG administration of Pt(SO4)2 at the LD1 level (one dose every 72 hr for up to 10 doses). Three days after administration of the final dose of each series, open-field and exploratory performance were measured and tissue/organ Pt levels determined. Tissue/organ Pt levels were variable but generally increased with dose number. No Pt was detected in the brain. Activity and explorations were marginally depressed. Only rearings correlated significantly with tissue Pt levels.
Treating Exposure to Chemical Warfare Agents: Implications for Health Care Providers and Community Emergency Planning
Authors: Nancy B. Munro, Annetta P. Watson, Kathleen R. Ambrose, Guy D. Griffin
Journal: Environmental Health Perspectives (1990)

Current treatment protocols for exposure to nerve and vesicant agents found in the U.S. stockpile of unitary chemical weapons are summarized, and the toxicities of available antidotes are evaluated. The status of the most promising of the new nerve agent antidotes is reviewed. In the U.S. atropine and pralidoxime compose the only approved antidote regimen for organophosphate nerve agent poisoning. Diazepam may also be used if necessary to control convulsions. To avoid death, administration must occur within minutes of substantial exposure together with immediate decontamination. Continuous observation and repeated administration of antidotes are necessary as symptoms warrant. Available antidotes do not necessarily prevent respiratory failure or incapacitation. The toxicity of the antidotes themselves and the individualized nature of medical care preclude recommending that autoinjectors be distributed to the general public. In addition, precautionary administration of protective drugs to the general population would not be feasible or desirable. No antidote exists for poisoning by the vesicant sulfur mustard (H, HD, HT); effective intervention can only be accomplished by rapid decontamination followed by palliative treatment of symptoms. British anti-Lewisite (BAL) (2,3-dimercapto-1-propanolol) is the antidote of choice for treatment of exposure to Lewisite, another potent vesicant. Experimental water-soluble BAL analogues have been developed that are less toxic than BAL. Treatment protocols for each antidote are summarized in tabular form for use by health care providers.
TUMORS OF THE BRAIN.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Research Highlights
Journal: Molecular Therapy (2012)

research highlights Low level of DNA sequence variation in iPSCs generated by episomal vectorsThere is keen interest in induced pluripotent stem cell (iPSC) technology for regenerative medicine, although the reprogramming process remains incompletely characterized.Several recent studies have linked reprogramming to genetic abnormalities in human iPSCs derived from fibroblasts.These abnormalities, which may be either preexisting or generated during reprogramming, may be selected for during iPSC induction and/or subsequent expansion.Researchers recently reported in Cell Stem Cell the whole-genome sequencing of three human iPSC lines derived from two cell types of an adult donor by episomal plasmid vectors based on the EBNA1/OriP replicon.The workers were unable to detect vector sequence in the deeply sequenced iPSC lines.They identified between 1,000 and 2,000 heterozygous single-nucleotide variants (SNVs)-but no copy number variants-in each iPSC line relative to the parental line.Between 6 and 12 of these SNVs were found within coding regions, but half of these were synonymous changes and none of the others was found within genes known to be associated with cancer development.The data suggest that episome-mediated reprogramming is not inherently mutagenic.