tbuckley/cabot-search huggingface dataset:
Pagophagia and iron lack
Authors: C. A. Coltman
Journal: JAMA (1969)

Iron lack was associated with an unusual perversion of appetite characterized by the ingestion of extraordinary amounts of ice. Pagophagia is defined as the purposeful ingestion of at least one ordinary tray of ice daily for a period in excess of two months. The symptom appears to be related to iron lack and is completely resolved with amounts of iron less than those required for resolution of the anemia or replenishment of iron stores. The data on the rates of repair of mucosal cytochrome and blood-cell hemoglobin coincide with the temporal relationship between the resolution of pagophagia and the correction of iron-lack anemia.
Abstract 2687: Arterial Stiffness Determines Baseline Coronary Flow And Flow Reserve In Untreated Patients With Arterial Hypertension
Authors: Ignatios Ikonomidis, John Lekakis, Helen Triantafyllidi, Costas Papadopoulos, Georgia Georgoula, Ioannis Paraskevaidis, Dimitrios T Kremastinos
Journal: Circulation (2007)

Arterial stiffness is a marker of subclinical atherosclerosis with prognostic significance. Coronary microcirculation is disturbed in patients with arterial hypertension. We investigated whether the arterial stiffness may determine baseline coronary flow and flow reserve (CFR) in never-treated hypertensives. METHODS: We studied 100 untreated consecutive patients (mean age: 55±11 years 53 male and 47 females), with newly diagnosed arterial hypertension and 20 controls matched for sex, age and atherosclerotic factors, Exclusion criteria were history of diabetes, familiar hyperlipidemia, CAD, cardiomyopathy and chronic obstructive pulmonary disease. We measured a) Carotid to femoral artery pulse wave velocity (PWV) as an estimate of arterial stiffness using the Complior apparatus b) Peak Systolic (Vs) and diastolic (Vd) coronary blood flow velocity , Vd/Vs ratio, Deceleration Time (DT-Vd) and time integral (VTI-Vd) of Vd using a 7MHZ transducer by means of colour-guided Doppler echocardiography at the distal tract of the LAD c) Ratio of VTI-Vd after adenosine infusion (140μg/kg/min) to VTI-Vd at baseline to assess coronary flow reserve (CFR) RESULTS: All patients had normal LVmass (men&lt;134gr/m2, women &lt;110gr/m2) and had higher PWV (10.4±1.7 vs. 8.2±1.4 m/s, p&lt;0.001) and lower CFR, Vd/Vs and DT-Vd (2.6±0.6 vs 3.4±0.7, p&lt;0.001, 1.78±0.31 vs. 1.97±0.38, p=0.04 and 973±226 vs. 1113±332 ms, p&lt;0.001 respectively) than controls. Increasing PWV was related to decreasing Vd/Vs (r=-0.65, p&lt;0.001) , DT-Vd (r=-0.8, p&lt;0.001), CFR (r=-0.7, p&lt;0.001) and VTI-Vd post adenosine (r=-0.24, p=0.034). In multivariate regression analysis, PWV and smoking were the most important determinants of CFR among age, sex, body mass index, mean blood pressure and hyperlipidemia (b: - 2.21, p&lt;0.001 and b: - 2.68, p=0.032 respectively). Patients with CFR&gt;2 had significantly lower PWV, than those with CFR&lt;2 (n=20) (10±1.5 vs. 12±2 m/s p&lt;0.001). By ROC analysis, a PWV&gt;10.7 m/sec predicted a CFR &lt; 2 with a 84% and 80% sensitivity and specificity respectively. CONCLUSIONS: Arterial stiffness determines with baseline coronary flow and flow reserve in never treated hypertensives with no evidence of LV hypertrophy.
Abstract 1728: The Defect in HDL Function and Reverse Cholesterol Transport Found in Diabetic Mice with the Haptoglobin 2–2 Genotype Can Be Corrected with High Dose Antioxidant Therapy
Authors: Rabea O Asleh, Rachel Miller-Lotan, Zaid Abassi, Andrew P Levy
Journal: Circulation (2008)

Background. The primary function of the haptoglobin (Hp) protein is to clear free hemoglobin (Hb). Two common alleles exist at the Hp locus (1 and 2). We recently demonstrated that reverse cholesterol transport is impaired in individuals with Diabetes Mellitus (DM) and the Hp 2–2 genotype which may explain the increased incidence of cardiovascular disease in this population. We sought to test the hypothesis that clearance of the Hp 2-Hb complex is slower in DM allowing more complex to bind to HDL thereby resulting in increased oxidative modification of HDL and inhibition of reverse cholesterol transport and determine if antioxidant therapy could restore normal HDL function in Hp 2–2 DM mice. Methods and Results. Injection of 125 I-labeled Hp 1 or Hp 2-Hb complexes into non-DM mice demonstrated that the half-life of the Hp 2-Hb complex was 2–3 fold longer than the Hp 1-Hb complex (57.8 ± 2.8 vs. 20.4 ± 1.7 min). Moreover, in DM the half-life of the Hp 2-Hb complex was doubled while the half-life of the Hp 1-Hb complex was unchanged (103 ± 3.9 vs. 18.6 ± 1.8 min). Coimmunoprecipitation studies demonstrated that over 25% of the injected Hp 2-Hb complex was associated with HDL in DM mice representing a greater than 10 fold increase compared to Hp 1-Hb complex in non-DM mice. Coimmunoprecipitation studies in Hp 0 (knockout) mice demonstrated that the Hp protein was absolutely necessary for the interaction of Hb with HDL. Reverse cholesterol transport was impaired by DM in Hp 2 mice but this impairment was prevented by high dose antioxidant supplementation to these mice. Conclusions. These data may explain why the Hp 2 genotype promotes less efficient reverse cholesterol transport in DM and suggests that strategies targeted to decrease oxidation of HDL by the Hp 2-Hb complex may improve HDL function.
Effect of glutathione S-transferase M1 polymorphisms on biomarkers of exposure and effects
Authors: R J Srám
Journal: Environmental Health Perspectives (1998)

Genotypes responsible for interindividual differences in ability to activate or detoxify genotoxic agents are recognized as biomarkers of susceptibility.Among the most studied genotypes are human glutathione transferases.The relationship of genetic susceptibility to biomarkers of exposure and effects was studied especially in relation to the genetic polymorphism of glutathione S-transferase Ml (GSTM1).For this review papers reporting the effect of GSTM1 genotype on DNA adducts, protein adducts, urine mutagenicity, Comet assay parameters, chromosomal aberrations, sister chromatid exchanges (SCE), micronuclei, and hypoxanthine-guanine phosphoribosl transferase mutations were assessed.Subjects in groups occupationally exposed to polycyclic aromatic hydrocarbons, benzidine, pesticides, and 1,3-butadiene were included.As environmentally exposed populations, autopsy donors, coal tar-treated patients, smokers, nonsmokers, mothers, postal workers, and firefighters were followed.From all biomarkers the effect of GSTM1 and N-acetyl transferase 2 was seen in coke oven workers on mutagenicity of urine and of glutathione S-transferase Ti on the chromosomal aberrations in subjects from 1,3-butadiene monomer production units.Effects of genotypes on DNA adducts were found from lung tissue of autopsy donors and from placentas of mothers living in an air-polluted region.The GSTM1 genotype affected mutagenicity of urine in sm6kers and subjects from polluted regions, protein adducts in smokers, SCE in smokers and nonsmokers, and Comet assay parameters in postal workers.A review of all studies on GSTM1 polymorphisms suggests that research probably has not reached the stage where results can be interpreted to formulate preventive measures.The relationship between genotypes and biomarkers of exposure and effects may provide an important guide to the risk assessment of human exposure to mutagens and carcinogens.
Environmental and Toxicological Aspects of Insect Growth Regulators
Authors: James E. Wright
Journal: Environmental Health Perspectives (1976)

Insect growth regulators (IGRs) are a class of new chemicals that interfere with maturation and reproduction in insects. Proposed hypotheses on the biochemical mechanism of action are presented herein. The environmental aspects as metabolism in soils, plants, insects, and animals suggest strongly that these chemicals undergo rapid degradation and metabolism to innocuous metabolites. The toxicological properties determined for registration of the IGR methoprene, isopropyl (E,E)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate, reflected no significant effects against any of the species tested. Toxicological evaluations in swine, sheep, hamsters, rats, dogs, rabbits, guinea pigs, and cattle revealed no clinical signs of toxicosis. Additionally, teratological studies in swine, sheep, hamsters, rats, and rabbits also resulted in no observable effects in the animals at the levels administered.
Abstract 2357: Identification of microRNAs associated with melanoma immunity and immunotherapy outcome
Authors: Robert A. Szczepaniak Sloane, Miles C. Andrews, Guangchun Han, Lauren Haydu, Elizabeth Burton, Gershenwald E. Jeffrey, Michael A. Davies, Linghua Wang, Scott Woodman, Jennifer Wargo
Journal: Cancer Research (2019)

Abstract Introduction:Resistance to immunotherapy is a significant clinical challenge, preventing or limiting response to PD1 checkpoint blockade in approximately 60% of melanoma patients. We sought to identify microRNAs (miRs) that modulate the tumour immune microenvironment and potentially influence outcome to immunotherapy.Methods:To identify miRs associated with immune infiltration and exclusion in melanoma, we first compared miR expression in the human skin cutaneous melanoma (SKCM) dataset from The Cancer Genome Atlas (TCGA) with a selection of immune correlates including histologic assessment of tumour infiltrating lymphocytes (TIL), gene expression-based cytolytic score using Granzyme A and Perforin 1, and transcriptomic estimation of immune cell populations using CIBERSORT. In parallel, we performed miR sequencing of 22 pre-PD-1 inhibitor treatment melanoma tumors to identify differentially-expressed miRs according to PD-1 inhibitor response. We then tested the immune effects of candidate immunomodulatory miRs using microRNA mimics in a panel of human melanoma cell lines, evaluating immunomodulatory cytokine secretion using a bead-based immunoassay (LEGENDplex) and cell surface expression of HLA-A and PD-L1 by flow cytometry.Results:We identified 14 microRNAs associated with immune infiltration or exclusion in the TCGA melanoma dataset. In vitro characterisation of these miRs showed that they regulate secretion of IL-6 and VEGF, and expression of HLA-A in human melanoma cell lines. Furthermore, we identified 25 downregulated and 8 upregulated miRs in responder vs non-responder melanoma lesions (log2 fold change &amp;gt;=1, padj&amp;lt;0.1), including several miRs with high-confidence targets involved in oncogenesis, cancer germline antigens and modification of the extracellular matrix that may impact upon susceptibility to immune attack.Conclusions:This study identified several immunomodulatory miRs associated with immune infiltration in melanoma tumors of TCGA. Several of these candidate immunomodulatory miRs show evidence of activity relevant to the efficacy of PD-1 checkpoint blockade, whilst additional response/resistance-associated miRs were identified. These miRs represent strong candidates for ongoing in vitro and in vivo studies in combination with immunotherapy. Citation Format: Robert A. Szczepaniak Sloane, Miles C. Andrews, Guangchun Han, Lauren Haydu, Elizabeth Burton, Gershenwald E. Jeffrey, Michael A. Davies, Linghua Wang, Scott Woodman, Jennifer Wargo. Identification of microRNAs associated with melanoma immunity and immunotherapy outcome [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2357.
Correction: Multiple Measures of Adherence to HIV Protease Inhibitors
Journal: Annals of Internal Medicine (2002)

Corrections15 January 2002Correction: Multiple Measures of Adherence to HIV Protease InhibitorsFREESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-2-200201150-00022 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In an article on multiple measures of adherence to HIV protease inhibitors (1), subheadings in Table 2 were published incorrectly. Under the headings “Week 8” and “Week 24,” the positions of the subheadings “Detectable Viral Load” and “Undetectable Viral Load” should be reversed.Reference1. Liu H, Golin CE, Miller LG, Hays RD, Beck CK, Sanandaji S, et al . A comparison study of multiple measures of adherence to HIV protease inhibitors. Ann Intern Med. 2001;134:968-77. [PMID: 11352698] LinkGoogle Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA Comparison Study of Multiple Measures of Adherence to HIV Protease Inhibitors Honghu Liu , Carol E. Golin , Loren G. Miller , Ron D. Hays , C. Keith Beck , Sam Sanandaji , Judith Christian , Tomasa Maldonado , Dena Duran , Andrew H. Kaplan , and Neil S. Wenger Metrics 15 January 2002Volume 136, Issue 2Page: 175KeywordsHIVProtease inhibitorsViral load ePublished: 15 January 2002 Issue Published: 15 January 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
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Authors: Shoji Kubo, Teh-Ia Huo, Po-Hong Liu, Chia-Yang Hsu, Atsushi Hiraoka, Kojiro Michitaka, Takashi Kumada, Masashi Kudo, Atsushi Hiraoka, Kojiro Michitaka, Takashi Kumada, Namiki Izumi, Norihiro Kokudo, Yutaka Matsuyama, Michiie Sakamoto, Takashi Kokudo, Masatoshi Kudo, Masumi Kadoya, Osamu Nakashima, Tadatoshi Takayama, Kosuke Kashiwabara, Jinsil Seong, Jason Chia-Hsien Cheng, Zhao-Chong Zeng, Sang Min Yoon, Ka-On Lam, Ann-Shing Lee, Ada Law, Jian-Ying Zhang, Yong Hu, Luca Cicalese, Loren Raun, Ali Shirafkan, Laura Campos, Daria Zorzi, Mauro Montalbano, Colin Rhoads, Valia Gazis, Katherine Ensor, Cristiana Rastellini, Yasuharu Imai, Kazuhiro Katayama, Masatoshi Hori, Takayuki Yakushijin, Kenji Fujimoto, Toshifumi Itoh, Takumi Igura, Mitsuru Sakakibara, Manabu Takamura, Masakatsu Tsurusaki, Hiroto Takahashi, Katsuyuki Nakanishi, Noriaki Usuki, Koh Tsuji, Hiroshi Ohashi, Tonsok Kim, Tetsuo Takehara, Takamichi Murakami, Alessandro Cucchetti, Clarence Yen, Rohini Sharma, Lorenza Rimassa, Tadaaki Arizumi, Dominik Bettinger, Huay Yee Choo, Tiziana Pressiani, Michela E. Burlone, Mario Pirisi, Laura Giordano, Anisa Abdulrahman, Masatoshi Kudo, Robert Thimme, Joong Won Park, David James Pinato, Yoshito Itoh, Michihisa Moriguchi, Takeshi Aramaki, Hideyuki Nishiofuku, Rui Sato, Koiku Asakura, Kanji Yamaguchi, Toshihiro Tanaka, Masahiro Endo, Rohan C. Siriwardana, Madunil A. Niriella, Anuradha Dassanayake, Bhagya Gunetilleke, Dileepa Ediriweera, Thenuka Sivasundaram, Janaka de Silva, Fabio Piscaglia, Antonio Daniele Pinna, Benjamin Djulbegovic, Federico Mazzotti, Luigi Bolondi, Charlotte E. Costentin, Cristina R. Ferrone, Ronald S. Arellano, Suvranu Ganguli, Theodore S. Hong, Andrew X. Zhu, Tse-Ming Kuo, Kai-Ming Chang, Tsun-I Cheng, Kuo-Jang Kao, Masatoshi Kudo, Mengensatzproduktion, Druckerei Stückle, Druckerei Stückle, The Liver Cancer Study Group of Japan
Journal: Liver Cancer (2017)
Screening for Syphilis Infection in Pregnant Women
Authors: Jennifer S. Lin, Michelle L. Eder, Sarah I. Bean
Journal: JAMA (2018)

The incidence of syphilis and congenital syphilis in the United States has increased after reaching historic lows in the early 2000s.To systematically review literature on the effectiveness and harms of screening for syphilis in pregnancy and the harms of penicillin treatment in pregnancy to inform the US Preventive Services Task Force.MEDLINE, PubMed, and the Cochrane Central Register of Controlled Trials for relevant English-language literature, published from January 1, 2008, to June 2, 2017. Ongoing surveillance was conducted through November 22, 2017.Studies conducted in countries categorized as "high" or "very high" on the Human Development Index that explicitly addressed 1 of 3 a priori-defined key questions.Independent critical appraisal and data abstraction by 2 reviewers. Data from included studies were narratively synthesized without pooling data.Incidence of congenital syphilis; any harms of screening or penicillin treatment in pregnancy.Seven studies in 8 publications were included. One observational study evaluated the implementation of syphilis screening in pregnancy in 2 441 237 women in China. From 2002 to 2012, screening for syphilis in all pregnant women increased from 89.8% to 97.2%, and the incidence of congenital syphilis decreased from 109.3 to 9.4 cases per 100 000 live births. Five studies (n = 21 795) evaluated the false-positive findings of treponemal tests and 1 study (n = 318) evaluated the false-negative findings of nontreponemal tests. These studies found that false-positives with treponemal-specific enzyme or chemiluminescent immunoassays were common (46.5%-88.2%), therefore warranting reflexive (automatic confirmatory) testing for all positive test findings. One study (n = 318) found no false-negatives with treponemal tests, and 1 study (n = 139) demonstrated the prozone phenomenon (false-negative response from high antibody titer) with rapid plasma reagin screening using undiluted samples (2.9%). No studies were identified for harms of penicillin in pregnancy.Screening for syphilis infection in pregnant women is associated with reduced incidence of congenital syphilis, and available evidence supports the need for reflexive testing for positive test results.
Altered Development of CD8+ T Cell Lineages in Mice Deficient for the Tec Kinases Itk and Rlk
Authors: Christine Broussard, Christine Fleischacker, Reiko Horai, Madeva Chetana, Ana M. Venegas, Leslie L. Sharp, Stephen M. Hedrick, B.J. Fowlkes, Pamela L. Schwartzberg
Journal: Immunity (2006)
The Pathology, Diagnosis, and Treatment of Cardiac Diseases
Authors: W. O. Markham
Journal: BMJ (1859)

I once saw a case of pericarditis, which resulted from ulceration of the cesophagus.The ulcer in its progress opened at last into the pericardium, and so permitted the contents of the stomach to pass into the pericardium.This is the only case of pneunio-pericardium which I have ever seen.The air, of course, came from the stomach in this instance.By gently pressing upon the stomach, its contents were readily forced, and seen to pass, up the cesophagus, and so through the ulcerated opening into the pericardium.
Erratum
Journal: BMJ (1904)

column not to make use of such signatures as " A Member," " A Mem- ber B.M.A.," " Eniquirer," and so on.By attention to this request much confusion would be avoided.Correspondents are asked to write upon one side of the paper only.G. asks what would be the usual capitatioin fees for attendance and medi- cines at an industrial school five miles distant, the average number of boys being about sixty-five
American Cancer Society-National Cancer Institute National Conference on Nutrition in Cancer
Journal: JNCI Journal of the National Cancer Institute (1977)

American Cancer Society-National Cancer Institute National Conference on Nutrition in Cancer Get access JNCI: Journal of the National Cancer Institute, Volume 59, Issue 5, November 1977, Page 1573, https://doi.org/10.1093/jnci/59.5.1573-a Published: 01 November 1977
Permanent cardiac pacemakers in Alaska natives with complete heart block
Authors: G. A. Katz
Journal: JAMA (1970)

Sixteen Alaska natives have been followed up after permanent cardiac pacemaker implantation, from July 1965 to May 1970. The indication for pacemaker implantation was persistent symptomatic complete heart block. The longest follow-up period was 57 months. The average follow-up period per patient was 17 months. There was no mortality during this time with a small number of pacemaker failures or complications. Many of the patients returned to live in remote villages. The success of this program indicates that permanent pacemakers can be used in patients who live in rural settings, far from hospital centers, as long as appropriate follow-up methods are employed.
THE LAYMAN, MEDICAL ADVERTISEMENTS AND THE NEWSPAPER
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE MOBILE CONVENTION.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chronic Myelogenous Leukemia Clinical Practice Guidelines in Oncology
Journal: Journal of the National Comprehensive Cancer Network (2003)

Chronic myelogenous leukemia (CML) accounts for 15% of adult leukemias. In 2003, an estimated 4,300 cases will be diagnosed, and 1,700 patients will die from the disease. The median age of patients with the disease is 53, but CML occurs in all age groups, with an increasing proportion of younger patients in more recent studies. CML progresses from a chronic phase to a rapidly fatal blastic phase, generally over 3 to 5 years. The blast phase is often preceded by a transition period, called the accelerated phase, which is marked by the acquisition of new cytogenetic abnormalities in 50% to 80% of patients. For the most recent version of the guidelines, please visit NCCN.org