tbuckley/cabot-search huggingface dataset:
Sonrotoclax (BGB-11417) in Combination with Dexamethasone for the Treatment of Relapsed/Refractory Multiple Myeloma with t(11;14): Safety, Efficacy, and Determination of Recommended Phase 2 Dose
Authors: Hang Quach, Doug Sborov, Dickran Kazandjian, Andrew Spencer, Michael Low, Susan Bal, Natalie S. Callander, Huan Cheng, Sheel Patel, Rocco J. Crescenzo, Amit Agarwal, Binod Dhakal
Journal: Blood (2023)
A Two-Part Study Evaluating the Combination of Tazemetostat and CPX-351 (Part 1) and Palbociclib with CPX-351 (Part 2) for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia
Authors: Gina Keiffer, Bruno Calabretta, Alexander Mazo, Ubaldo Martinez Outschoorn, Onder Alpdogan, Adam F. Binder, Pierluigi Porcu, Lindsay Wilde, Margaret Kasner
Journal: Blood (2023)
Efficacy of Daratumumab-Based Regimens in Anti-CD38 Treatment-Naïve Relapsed/Refractory Multiple Myeloma with High-Risk Cytogenetics
Authors: Jordan Snyder, Razan Mansour, Aytaj Mammadzadeh, Hamza Hashmi, Aimaz Afrough, Omar Alkharabsheh, Barry Paul, Shebli Atrash, Muhammad Umair Mushtaq, Barry S. Skikne, Nausheen Ahmed, Al-Ola Abdallah
Journal: Blood (2023)
Unraveling Diverse Mechanisms of Complex Structural Variant Interactions through Multiomic Data in Multiple Myeloma
Authors: Enze Liu, Nathan Becker, Parvathi Sudha, Aneta Mikulasova, Mohammad Abu Zaid, Attaya Suvannasankha, Kelvin P. Lee, Rafat Abonour, Brian A. Walker
Journal: Blood (2023)
Role of Microenvironment in Influencing the Activity of CD19 CAR T Cells in B-Cell Precursor Acute Lymphoblastic Leukemia (B-ALL)
Authors: Marianna Ponzo, Lorenzo Drufuca, Chiara Buracchi, Silvia Nucera, Cristina Bugarin, Grazisa Rossetti, Raoul Bonnal, Benedetta Rambaldi, Andrea Biondi, Giuseppe Gaipa, Massimiliano Pagani, Chiara Francesca Magnani
Journal: Blood (2023)
RNA Splicing Factor Mutations Drive Aberrant Canonical and Cryptic Circular RNA Biogenesis in Leukemia
Authors: Mike Fernandez, Meiling Jin, Qiong Jia, Yiming Wu, Kevyn Hart, Emilee Bargoma, Joseph Pangallo, Robert K. Bradley, Omar Abdel-Wahab, Zhenyu Jia, Ren-Jang Lin, Lili Wang
Journal: Blood (2023)
Single-Cell RNA-Seq Analysis Reveals Distinct Tumor and Immunosuppressive T Cell Phenotypes in CLL Patients Treated with Ibrutinib
Authors: Shanmugapriya Thangavadivel, Shrilekha Misra, Samon Benrashid, Britten Gordon, Alexander He, Tzung-Huei Lai, Kerry A Rogers, Seema A Bhat, Adam S Kittai, John C. Byrd, James S. Blachly, Jennifer A. Woyach, Bradley Wayne Blaser
Journal: Blood (2023)
Implementing a Structured Health Care Transition (HCT) Process for Sickle Cell Disease Using Quality Improvement: Results from the Sickle Cell Trevor Thompson Transition Project HCT Learning Collaborative
Authors: Ifeyinwa Osunkwo, Jennifer Cornette, Cheryl Courtlandt, Myra Robinson, Patience White, Margaret McManus, Laura Noonan, Payal Desai, Charity Patterson, James R. Eckman, Ramona Lawrence
Journal: Blood (2023)
Liquid Biopsy Enhances Diagnostic Workup of Hereditary Alpha-Tryptasemia (HaT) and Systemic Mastocytosis (SM) in Patients with Mast Cell-Mediated Symptoms and Elevated Basal Tryptase Levels
Authors: Daniel Koch, Hannah Stocker, Friederike Wortmann, Franziska Axt, Cyrus Khandanpour, Eva Dazert, Christian Sina, Dagmar von Bubnoff, Nikolas Von Bubnoff
Journal: Blood (2023)
A 5-Stage System for ASCT Multiple Myeloma
Authors: Wancheng Guo, David E. Mery, Eric Siegel, Fumou Sun, Yan Cheng, Visanu Wanchai, Cody Ashby, Clyde Bailey, Daisy V. Alapat, Hongling Peng, Samer Al Hadidi, Sharmilan Thanendrarajan, Carolina Schinke, Maurizio Zangari, Frits van Rhee, Guido Tricot, John D Shaughnessy, Jr, Fenghuang Zhan
Journal: Blood (2023)
A Phase 1 Cohort Dose Escalation and Expansion Trial to Determine the Safety, Tolerance, Maximum Tolerated Dose, and Preliminary Antineoplastic Activity of IKS03 in Patients with Advanced B-Cell Non-Hodgkin Lymphomas (NHL)
Authors: Sarit Assouline, Katharine L. Lewis, Rosemary Anne Harrup, Robert J Lutz, Jenny Thirlway, Jutta Deckert, David M Browning, Debra L Wood, Paul I. Nadler, Seung Tae Lee
Journal: Blood (2023)
Clinical Breakthrough Hemolysis (BTH) during Monotherapy with the Oral Factor B Inhibitor Iptacopan Is Generally Not Severe and Managed without Treatment Discontinuation: 48-Week Data from the Phase III Apply-PNH and Appoint-PNH Trials in Paroxysmal Nocturnal Hemoglobinuria (PNH)
Authors: Regis Peffault De Latour, Austin Kulasekararaj, Phillip Scheinberg, Philippe Ferber, Tomasz Lawniczek, Christine Thorburn, Marion Dahlke, Antonio M Risitano
Journal: Blood (2023)
Extended Follow up of a Phase 2 Study of Early Intervention with Lenalidomide in Patients with High-Risk Chronic Lymphocytic Leukemia
Authors: Kerry A Rogers, Qiuhong Zhao, Seema A Bhat, John C. Byrd, Cara Grantier, Michael R. Grever, Corinne Hoffman, Adam S Kittai, Gerard Lozanski, Margaret S. Lucas, Lindsey Rike, Shanmugapriya Thangavadivel, William E. Carson III, Jennifer A. Woyach
Journal: Blood (2023)
Responses and Outcomes after Second-Line Therapy in Transplant-Eligible Patients with DLBCL Relapse over 1 Year after First-Line Therapy
Authors: David A Qualls, Gunjan L. Shah, Roni Shouval, Philip Caron, Kevin A. David, Lorenzo Falchi, Paola Ghione, Paul A. Hamlin, Steven M. Horwitz, Andrew M. Intlekofer, William Johnson, Anita Kumar, Oscar Boutros Lahoud, Jennifer Kimberly Lue, Alison Moskowitz, Ariela Noy, Maria Lia Palomba, Pallawi Torka, Santosha A Vardhana, Andrew D. Zelenetz, Michelle Okwali, Parastoo Bahrami Dahi, Michael Scordo, Richard J. Lin, Miguel-Angel Perales, Gilles Salles
Journal: Blood (2023)
<i>Functional Characterization of Genes Residing in Chromosomal Regions with “High-Risk” Lesions in Multiple Myeloma</i>
Authors: Phaik Ju Teoh, Ricardo De Matos Simoes, Tae-Hoon Chung, Torsten Steinbrunn, Lisa B Leypoldt, Olga Dashevsky, Francisca Vazquez, Wee-Joo Chng, Constantine S Mitsiades
Journal: Blood (2023)
Sabatolimab in Combination with Hypomethylating Agents (HMAs) Was Safe in Patients (Pts) with Intermediate-, High-, or Very-High-Risk Myelodysplastic Syndrome (MDS)
Authors: Guillermo Garcia-Manero, Roger M. Lyons, Savita Nandal, Mushtaq Ashraf, Ramarao Thellaboina, Julie Ruckel-Kumar, Hans D. Menssen, Amer M. Zeidan
Journal: Blood (2023)
Real-World Mobilization, Harvest, and Transplant Outcomes in Newly Diagnosed Multiple Myeloma Patients Receiving D-VTd: A UK Centre Experience
Authors: Christianne Bourlon, Katharine Elizabeth Bailey, Reuben Benjamin, Kirsty Cuthill, Arief Gunawan, Majid Kazmi, Pramila Krishnamurthy, Victoria Potter, Robin Sanderson, Michelle Kenyon, Mili Shah, Matthew Streetly, Fabio Serpenti, Stella J. Bowcock, Lalita Banerjee, John Robert Jones, Sabia Rashid, Ana Isabel Duran Maestre, Satyajit Sahu, Sudarshan Gurung, Lianwea Chia, Haili Cui, Alison Pratt, Maheen Ahsan, Stella Bouziana
Journal: Blood (2023)
Modakafusp Alfa Demonstrates Type I Interferon-Mediated Innate and Adaptive Immune Enhancement in a Phase 1/2 Study in Patients with Relapsed and/or Refractory Multiple Myeloma (RRMM)
Authors: Gurpanna Saggu, Min Young Lee, Faith Dunbar, Reshma Singh, Kris Sachsenmeier, Dan T. Vogl, Shebli Atrash, Sarah A. Holstein, Omar Nadeem, Jonathan L. Kaufman, Adarsh Joshi, Kaveri Suryanarayan, Sabrina Collins
Journal: Blood (2023)
Brazilian Non-Hodgkin T Cell Registry: An Exploratory Analysis of Extranodal Sites
Authors: Thais Fischer, Eliana C M CM Miranda, Nelson Castro, Juliana Pereira, Davimar Miranda Maciel Borducchi, Samuel de S Medina, Sergio Augusto B Brasil, Danielle Leao Cordeiro De Farias, Marcelo Bellesso, Jamila Vaz Tavarez, Karin Z Cecyn, Rony Schaffel, Samir Nabhan, Frederico Lisboa Nogueira, Renata Baptista, Fernando Barroso, Renata R Souza, Mateus Dalló Dal Pont, Carolina Colaço Vilarim, Claudio G Macedo, Ademar Dantas Cunha, Patricia Giacon, Elizete Negreiros, Nelson Hamerschlak, Vera Figueiredo, Diego Vila Cle, Natalia Pin Chuen Zing, Maria Almeida Dias, Rafael Gaiolla, Yung Bruno Gonzaga, Joao Tadeu Damian Souto Filho, Eduardo F O Ribeiro, Gilnara Fontinele Silva, Suellen Ka Gi Mo, Guilherme F Perini, Milena Matedi, Abrahão Elias Hallack Neto, Yana S Rabelo, Massimo Federico, Carmino A Souza, Carlos Chiattone
Journal: Blood (2023)
Optimized Double-Unit Cord Blood Transplantation Mitigates Transplant-Related Mortality Resulting in High Progression-Free Survival in Adults with Hematologic Malignancies
Authors: Ioannis Politikos, Sean M. Devlin, Stephanie Chinapen, Sean Quach, Parastoo B. Dahi, Boglarka Gyurkocza, Ann A. Jakubowski, Esperanza B. Papadopoulos, Doris M. Ponce, Roni Tamari, Andromachi Scaradavou, Juliet N Barker
Journal: Blood (2023)
Dynamics of Fecal Antibiotic-Resistance Genes after Fecal Microbiota Transplantation in Allogeneic Hematopoietic Cell Transplant Recipients and AML Patients: Results from a Randomized Placebo-Controlled Trial
Authors: Armin Rashidi, Maryam Ebadi, Tauseef Ur Rehman, Heba Elhusseini, David Kazadi, Hossam Halaweish, Chang Liu, Mohammad H Khan, Andrea Hoeschen, Qing Cao, Xianghua Luo, Amanda Kabage, Sharon Lopez, Shernan G. Holtan, Daniel Weisdorf, Alexander Khoruts, Satoshi Ishii, Christopher M Staley
Journal: Blood (2023)
CD49d Shapes B Cell Receptor Responsiveness and Tissue Distribution in an Aggressive Chronic Lymphocytic Leukemia Murine Model
Authors: Laura Polcik, Danielle-Justine Danner, Riccardo Bomben, Tamara Bittolo, Lixia Li, Driti Ashok, Sandra Kissel, Natalie Koehler, Andrea Härzschel, Geoffroy Andrieux, Melanie Boerries, Sophia Engel, Theresa Haslauer, Jan Hoepner, Nadja Zaborsky, Richard Greil, Cornelius Miething, Khalid Shoumariyeh, Jesus Duque Afonso, Justus Duyster, Antonella Zucchetto, Valter Gattei, Tanja Nicole Hartmann
Journal: Blood (2023)
Clinical Outcomes Associated with Del(17p) in Newly Diagnosed Multiple Myeloma Treated with Triplet and Daratumumab-Based Quadruplet Induction Regimens
Authors: Eric Jurgens, Ross Firestone, Kylee H Maclachlan, David Nemirovsky, Andriy Derkach, Malin Hultcrantz, Hani Hassoun, Sham Mailankody, Urvi A Shah, Sridevi Rajeeve, Dhwani Patel, Tala Shekarkhand, Colin Rueda, Yanming Zhang, Oscar Boutros Lahoud, Gunjan L. Shah, Michael Scordo, David Chung, Heather Landau, Sergio A. Giralt, Alexander Lesokhin, Neha Korde, Saad Z Usmani, Carlyn Tan
Journal: Blood (2023)
Elranatamab Exposure-Efficacy Analysis in Patients with Relapsed or Refractory Multiple Myeloma: Insights from Pooled Magnetismm Studies
Authors: Hoi Kei Lon, Jennifer Hibma, Jason Williams, Diane Wang, David Gifondorwa, Wei An Ma, Lindsay King, Umberto Conte, Akos Czibere, Mohamed Elmeliegy
Journal: Blood (2023)
Clinical Determinants of Early Mortality Following Allotransplantation for Acute Lymphoblastic Leukemia in a Brazilian Multicenter Registry
Authors: Dalila Cysne, Wellington F Silva, Mariana Nassif Kerbauy, Iago Colturato, Ana Maia, Luciana Tucunduva, George Barros, Vergilio Colturato, Nelson Hamerschlak, Vanderson Rocha
Journal: Blood (2023)
Response to Mosunetuzumab in Patients with B-Cell Lymphomas Relapsed or Refractory after CAR-T Cell Therapy Is Associated with Changes in Lymphocyte Counts
Authors: Elise A. Chong, Elicia Penuel, Nancy L. Bartlett, Francesc Bosch, L. Elizabeth Budde, Keith Fay, Ian W. Flinn, Andre Goy, Anita Kumar, Rachel Lundberg, Ellen B. Napier, Loretta J. Nastoupil, Mazyar Shadman, Michael C. Wei, Mei Wu, Shen Yin, Emeline R. Chong, Stephen J. Schuster
Journal: Blood (2023)
Five Year Outcomes of Patients with Large B-Cell Lymphoma Treated with Standard-of-Care Axicabtagene Ciloleucel: Results from the US Lymphoma CAR-T Cell Consortium
Authors: Jay Y. Spiegel, Michael D. Jain, Loretta J. Nastoupil, John Tamaresis, Armin Ghobadi, Yi Lin, Lazaros J. Lekakis, Patrick M. Reagan, Olalekan O. Oluwole, Joseph P McGuirk, Abhinav Deol, Kathleen Dorritie, Alison R Sehgal, Andre Goy, Brian T. Hill, Charalambos Andreadis, Javier L. Munoz, Matthew L. Ulrickson, Jason Westin, Julio C. Chavez, Dilan A Patel, Miriam T. Jacobs, Radhika Bansal, N. Nora Bennani, Vivek Patel, Aaron P. Rapoport, Julie M. Vose, David B. Miklos, Sattva S. Neelapu, Frederick L. Locke, Matthew A Lunning, Saurabh Dahiya
Journal: Blood (2023)
Impact of HLA-DQ Heterodimer Group (G1/G2) Mismatch on Relapse and Survival Following Haploidentical Donor Transplantation
Authors: Scott R. Solomon, Michael T Aubrey, Xu Zhang, Lizamarie Bachier-Rodriguez, Lawrence Morris, H. Kent Holland, Christina Roark, Katelin C Jackson, Asad Bashey, Melhem M. Solh
Journal: Blood (2023)
Access and Outcomes of Minority Health Populations Receiving Commercial Anti-CD19 CART Therapy for Non-Hodgkin Lymphoma
Authors: Guido Ghilardi, Staci Williamson, Raymone Pajarillo, Luca Paruzzo, Linhui Chen, Connor Grady, Abigail Doucette, Eneida R Nemecek, Giulia Gabrielli, Stefan K. Barta, Jakub Svoboda, Elise A. Chong, Rebecca Yelton, Dwivedy S. Nasta, Daniel J. Landsburg, Ositadimma Ugwuanyi, Andy Chen, Levanto Schachter, Griffin W White, Hatcher Ballard, Elizabeth Weber, Cara Curley, David L. Porter, Alfred L. Garfall, Wei-Ting Hwang, Carmen E Guerra, Richard T Maziarz, Stephen J Schuster, Marco Ruella
Journal: Blood (2023)
Canadian Cancer Trials Group SC.26 - Emotion and Symptom-Focused Engagement (EASE): A Multi-Site Randomized Controlled Trial of an Intervention for Individuals with Acute Leukemia
Authors: Troy Climans, Camilla Zimmermann, Annette E. Hay, Harriet Richardson, Pierre Villeneuve, Lee Mozessohn, Andre C. Schuh, Janique Dyba, Breffni Hannon, David Lee, Rena Buckstein, Argin Malakian, Kyle Fitzgibbon, Joel Lefebvre, Wei Tu, Gary Rodin
Journal: Blood (2023)
Distance to Care Predicts Clinical Trial Enrollment on COG ALL Clinical Trials: A Report from the Children's Oncology Group
Authors: Lena E Winestone, Sumit Gupta, Jeannette Sample, David Van Riper, Katherine Knowles, Zhiguo (Bruce) Chen, Bo Jiang, Maria C Velez, Mignon L. Loh, Philip J. Lupo, Naomi J Winick, Erin Marcotte
Journal: Blood (2023)
Influence of Co-Mutational Patterns in Disease Phenotype and Clinical Outcomes of Chronic Myelomonocytic Leukemia
Authors: Guillermo Montalban-Bravo, David Swanson, Rashmi Kanagal-Shamanna, Juan Jose Rodriguez-Sevilla, Danielle E. Hammond, Kelly S. Chien, Koji Sasaki, Elias Jabbour, Courtney D. DiNardo, Koichi Takahashi, Nicholas J. Short, Ghayas C. Issa, Naveen Pemmaraju, Tapan M. Kadia, Farhad Ravandi, Naval Daver, Gautam Borthakur, Sanam Loghavi, Sherry Pierce, Carlos E. Bueso-Ramos, Hagop M. Kantarjian, Guillermo Garcia-Manero
Journal: Blood (2023)
A Matching-Adjusted Indirect Comparison of the Efficacy of Elranatamab and Teclistamab in Patients with Triple-Class Exposed/Refractory Multiple Myeloma
Authors: Isha Mol, Yannan Hu, Thomas W LeBlanc, Joseph C Cappelleri, Haitao Chu, Guido Nador, Didem Aydin, Alex Schepart, Patrick Hlavacek
Journal: Blood (2023)
Hdp-101, an Anti-BCMA Antibody-Drug Conjugate with a Novel Payload Amanitin in Patients with Relapsed Multiple Myeloma, Initial Findings of the First in Human Study
Authors: Marc S. Raab, Jonathan L. Kaufman, Shambavi Richard, Sebastian Grosicki, Istvan Takacs, Andras Strassz, Andreas Martin Pahl, Thorsten Michael, Anette Last, Hajnalka Szaboki, Garrit Jentsch, Oliver Schönborn-Kellenberger, Robert Z. Orlowski
Journal: Blood (2023)
Sting Activation in Bone Marrow Macrophages Targets AML Blasts for Phagocytosis in an ICAM-1 Dependent Mechanism
Authors: Ravindu De Silva, Matthew Markham, Rebecca S Maynard, Katherine Hampton, Charlotte Hellmich, Dominic Fowler-Shorten, Kristian Bowles, Stuart Rushworth
Journal: Blood (2023)
<i>Rps19 and Rpl5 Play Distinct Roles in</i> <i>hematopoietic</i> <i>Stem Cell</i> <i>maintenance</i> <i>and Erythroid Differentiation</i>
Authors: Yuefeng Tang, Te Ling, Mushran Khan, Riaz Rao, Vincent P Schulz, Julien Papoin, Anupama Narla, Jeffrey Michael Lipton, James Palis, Laurie A. Steiner, Patrick G Gallagher, Mohandas Narla, John D. Crispino, Lionel Blanc
Journal: Blood (2023)
Lung Megakaryocytes Arise from a Flt3 - Cell Lineage and Contribute to Recovery of Platelet Counts in Thrombocytopenic States
Authors: Alison C. Livada, Kathleen E. McGrath, Sara Blick-Nitko, Chen Li, Paul D. Kingsley, Leah A. Vit, Sara Ture, Anne Koniski, James Palis, Craig Morrell
Journal: Blood (2023)
RUNX1 Mutation Does Not Significantly Impact the Outcome of Newly Diagnosedadult AML: A Retrospective Study of Chinese AML Patients
Authors: Chao-Ling Wan, Yuan-Hong Huang, Si-Man Huang, Tong-Tong Zhang, Kai-Wen Tan, Yan Qiu, Xiang-Dong Shen, Shuai-Shuai Ge, Han-Yu Cao, Yan-Yan Li, Songbai Liu, Qiao-Cheng Qiu, Haiping Dai, Sheng-Li Xue
Journal: Blood (2023)
Towards a Decision Engine for Therapeutic Optimization of Relapsed Refractory Multiple Myeloma
Authors: Yael C. Cohen, Mor Zada, Shuang-Yin Wang, Assaf Weiner, Natan Melamed, Polina Stepensky, Moshe E Gatt, Shlomit Kfir-Erenfeld, Nathalie Asherie, Eyal Lebel, Irit Avivi Mazza, Anna Gurevich Shapiro, Iuliana Vaxman, Tamir Shragai, Paulina Chalan, Eyal David, Ido Amit
Journal: Blood (2023)
Decoding the Historical TALE: COVID-19 Impact on Hematological Malignancy Patients - Insights from 2020 to 2022
Authors: Francesco Marchesi, Jon Salmanton-García, Francesca Farina, Barbora Weinbergerova, Federico Itri, Julio Dávila-Valls, Sonia Martín-Pérez, Andreas Glenthoej, Ditte Hersby, Maria Gomes Da Silva, Raquel Nunes-Rodrigues, Raul Cordoba, Alberto Lopez Garcia, Ziad Emarah, Shaimaa El-Ashwah, Yavuz M. Bilgin, Laman Rahimli, Oliver Cornely, Livio Pagano
Journal: Blood (2023)
Microbiome Signature ofnon-Responder to Fecal Microbiota Transplantation in Patient with Steroid-Refractory Chronic Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation
Authors: Kaibo Yang, Fen Huang, Jing Du, Li Xuan, Na Xu, Zhiping Fan, Qifa Liu
Journal: Blood (2023)
Genomic, Transcriptional, and Immunological Validation of Distinct Molecular Subtypes of Classic Hodgkin Lymphoma through Tissue-Based and Noninvasive Methods
Authors: Stefan K. Alig, Mohammad Shahrokh Esfahani, Andrea Garofalo, Michael Yu Li, Cédric Rossi, Timothy Flerlage, Jamie E. Flerlage, Ragini Adams, Michael S. Binkley, Navika Shukla, Michael Jin, Mari Olsen, Adele Telenius, Jurik A Mutter, Joseph Schroers-Martin, Brian J. Sworder, Shinya Rai, Daniel King, Andre Schultz, Jan Lukas Bögeholz, Shengqin Su, Karan R Kathuria, Chih Long Liu, Xiaoman Kang, Deanna M. Langfitt, Kristine Faye Pobre-Piza, Feng Tian, Maya J. Strohband, Valeria Spina, Thomas Tousseyn, Lieselot Buedts, Luc-Matthieu Fornecker, Sharon M. Castellino, Ranjana H. Advani, Davide Rossi, Ryan C Lynch, Herve Ghesquieres, Olivier Casasnovas, David M. Kurtz, Lianna J. Marks, Michael P. Link, Marc Andre, Peter Vandenberghe, Christian Steidl, Maximilian Diehn, Ash A. Alizadeh
Journal: Blood (2023)
Patterns of Care and Outcome in Adolescent and Young Adults (AYA) Lymphomas- a Multicenter HCC (Hematologic Cancer Consortium) Registry Study from India
Authors: Lingaraj Nayak, Sushil Selvarajan, Hasmukh Jain, Parathan Karunakaran, Prasanth Ganesan, Jayachandran Perumal Kalaiyarasi, Nikita Mehra, Anu Korula, Uday Kulkarni, Aby Abraham, Alok Parekh, Ritam Joarder, Santhosh Kumar Devadas, Jina Bhattacharyya, Dubashi Biswajit, Vineetha Raghavan, Mobin Paul
Journal: Blood (2023)
Long-Term Safety and Efficacy of Mitapivat, an Oral Pyruvate Kinase Activator, in Adults with Sickle Cell Disease: Extension of a Phase 1 Dose Escalation Study
Authors: Anna Conrey, Ingrid Frey, Nancy Asomaning, Ruth Pierre Charles, Dina Parekh, Julia Xu, Kang Le, Britney Kruah, Quan Li, Emily Dunkelberger, Troy Cellmer, Amber M Yates, Megan Wind-Rotolo, Neal Jeffries, William A Eaton, Swee Lay Thein
Journal: Blood (2023)
Impact of Post-Transplant Cyclophosphamide (PTCY)-Based Prophylaxis in Matched Sibling Donor Allo-HCT for Patients with Myelodysplastic Syndrome: A Study on Behalf of the Chronic Malignancies Working Party of the EBMT
Authors: Maria Queralt Salas, Dirk-Jan Eikema, Linda Koster, Johan Maertens, Jakob Passweg, Jürgen Finke, Annoek E.C. Broers, Yener Koc, Nicolaus Kröger, Zubeyde Nur Ozkurt, Maria Jesús Pascual, Uwe Platzbecker, Gwendolyn Van Gorkom, Thomas Schroeder, Jose Luiz Lopez Lorenzo, Massimo Martino, Simona Sica, Martin Kaufmann, Francesco Onida, Carmelo Gurnari, Christof Scheid, Joanna Drozd-Sokolowska, Kavita Raj, Marie Robin, Donal P McLornan
Journal: Blood (2023)
Exploration of Language As a Barrier to the Assessment and Management of CAR T-Cell Therapy Associated Toxicities
Authors: Megan Melody, Narendranath Epperla, Matthew J Cortese, Jason T. Romancik, Tamara K. Moyo, Vaishalee P Kenkre, Thomas Ollila, Lindsey Fitzgerald, Brian Hess, Kevin A. David, Kaitlin Annunzio, Megan Herr, Rahul S. Bhansali, Elyse I Harris, James A Davis, Oluwatobi Odetola, Adam Yuh Lin, Shuo Ma, Jonathan Moreira, Jane N. Winter, Deborah M. Stephens, Alexey Danilov, Nirav N. Shah, Jonathon B. Cohen, Geoffrey P. Shouse, Ishan Roy, Stefan K. Barta, Leo I. Gordon, Reem Karmali
Journal: Blood (2023)
Pancreatic Cancer's PD1-Roadblock: When T-Cell Reinvigoration Is Not Enough
Authors: Varintra E. Lander, David G. DeNardo
Journal: Clinical Cancer Research (2023)

Summary PD1-blockade combinations in pancreatic ductal adenocarcinoma have been poorly effective, and the underlying reasons for this are unknown. A recent study revealed that chemoradiation plus PD1-blockade reinvigorates tumor-specific T cells; however, this T-cell activation is accompanied with exaggerated NFκB signaling, which may limit productive tumor-controlling immunity. See related article by Ali et al., p. 542
New T-Cell Therapies for Brain Metastasis, CD133 in the Driver's Seat
Authors: Anthony R. Sloan, Mihika Thapliyal, Justin D. Lathia
Journal: Clinical Cancer Research (2023)

Summary Chimeric antigen receptor (CAR)-T cell immunotherapy has revolutionized cancer therapy for some advanced cancers, but success is predicated on identifying the correct cell surface target. In a recent article, the authors leveraged the cancer stem cell surface antigen CD133 to develop a CAR-T therapy for brain metastasis. See related article by Kieliszek et al., p. 554
Cael-101 Enhances the Clearance of Light Chain Fibrils and Intermediate Aggregates By Phagocytosis
Authors: Matt Costello, Nina Park, Alyssa Neill, Edmond Wong, Karin Müller, Andrew Proffitt, Richie Huynh, Vishwa Rao, Fang Sun, Aaron Bozzi, Meera Ramanujam, Sahar Usmani-Brown
Journal: Blood (2023)
Odronextamab Monotherapy for the Treatment of Relapsed/Refractory (R/R) Follicular Lymphoma (FL) and Diffuse Large B-Cell Lymphoma (DLBCL): Focus on Clinical Pharmacology and Pharmacometrics in the ELM-1 and ELM-2 Studies
Authors: Min Zhu, Daniela Conrado, Kamal Srinivasan, Jurriaan Brouwer-Visser, Hong Yan, Hesham Mohamed, Aafia Chaudhry, Srikanth Ambati, Lutz Harnisch, John D Davis
Journal: Blood (2023)
The XPO1-FOXC1-HOX Functional Axis Opens New Therapeutic Avenues to Treat DEK-NUP214 AML Patients
Authors: Fadimana Kaya, Findlay Bewicke-Copley, Pedro Casado Izquierdo, Jiexin Zheng, Juho Jalmari Miettinen, Naeem Khan, Szilvia Krizsán, Joseph J Saad, Vincent-Philippe Lavallée, Alexis Nolin-Lapalme, Josée Hébert, Janet Matthews, Marianne Grantham, Doriana Di Bella, Krister Wennerberg, Alun Parsons, John G. Gribben, James D. Cavenagh, Sylvie D Freeman, Csaba Bödör, Guy Sauvageau, Caroline A. Heckman, Jun Wang, Jean-Baptiste Cazier, David Taussig, Dominique Bonnet, Pedro R Cutillas, Kevin Rouault-Pierre, Jude Fitzgibbon, Ana Rio-Machin
Journal: Blood (2023)
Outcomes of Patients with Small Lymphocytic Lymphoma (SLL) Receiving First Line Treatment
Authors: Samuel Kosydar, Kari G. Rabe, Yucai Wang, Saad S. Kenderian, Wei Ding, Eli Muchtar, Jose F. Leis, Amber Koehler, Mazie Tsang, Ricardo Parrondo, Talal Hilal, Rachel Bubik, Susan Marie Schwager, Curtis A. Hanson, Esteban Braggio, Susan L. Slager, Min Shi, Daniel L. Van Dyke, Timothy G. Call, Neil E. Kay, Sameer A. Parikh, Paul J Hampel
Journal: Blood (2023)
Patient Characteristics, Treatment Patterns, and Health Outcomes in a Real-World Population of Patients with Myelofibrosis Treated with Fedratinib
Authors: Francesco Passamonti, Rohan C. Parikh, Siddhi Korgaonkar, Manoj Chevli, Samantha Slaff, Julien Rombi, Basirat Adeyemi, Keith L. Davis, Aylin Yucel
Journal: Blood (2023)