Metoclopramide: Pharmacology and Clinical Application
Authors: RIYAD ALBIBI
Journal: Annals of Internal Medicine (1983)

Review1 January 1983Metoclopramide: Pharmacology and Clinical ApplicationRIYAD ALBIBI, M.D., RICHARD W. McCALLUM, M.D.RIYAD ALBIBI, M.D., RICHARD W. McCALLUM, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-1-86 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMetoclopramide antagonizes the effect of dopamine in the central nervous system and other organ systems. Metoclopramide's effect on the medullary chemoreceptor trigger zone makes it useful as a routine anti-emetic and in preventing vomiting induced by antineoplastic drugs, particularly cisplatin. Metoclopramide's gastrointestinal smooth muscle stimulatory effects are related to its ability to antagonize the inhibitory neurotransmitter, dopamine; to augment acetylcholine release and sensitize the muscarinic receptors of the gastrointestinal smooth muscle; and to coordinate gastric-pyloric-small intestinal motor function. The indications for which metoclopramide is approved in the United States are reviewed. Adverse effects, which may occur in up to 20%...References1. BESANCOULAVILLETHOMINET JCM. Le metoclopramide et ses homoloques: introduction a leur etude biologique. C R Acad Sci (Paris). 1964;258:4384-6. MedlineGoogle Scholar2. PINDERBROGDENSAWYERSPEIGHTAVERY RRPTG. Metoclopramide: a review of its pharmacological properties and clinical use. Drugs. 1976;12:81-131. CrossrefMedlineGoogle Scholar3. OKWUASABAHAMILTON FJ. The effect of metoclopramide on intestinal muscle responses and the peristaltic reflex in vitro. Can J Physiol Pharmacol. 1976;54:393-404. 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