POS0146 INCREASED RISKS OF AORTIC REGURGITATION AND ATRIAL FIBRILLATION IN RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS PATIENTS: A 10 YEAR NATIONWIDE COHORT STUDY
Authors: H. K. Min, K. Y. Kang, H. R. Kim, S. H. Lee, S. Park, M. Park, Y. S. Hong, M. Y. Kim, S. H. Park
Journal: Annals of the Rheumatic Diseases (2022)

Background Radiographic axial spondyloarthritis (r-axSpA) has increased risk of cardiovascular disease. Other cardiac manifestations such as conduction disturbance and valvular diseases were also suggested as co-morbidities in r-axSpA patients, however, the risk of these cardiac manifestation in r-axSpA were seldomly evaluated in large cohort. Objectives To compare the incidences of aortic regurgitation, atrial fibrillation (AF), and atrioventricular (AV) block II–III between r-axSpA patients and the general population (GP). Methods National Health Insurance Services data were used. R-axSpA patients (N = 8,877) and the age- and sex-matched GP (N = 26,631) were followed from August, 2006 to December, 2019. Incidence rates and standardized incidence ratios (SIR) of aortic regurgitation, AF, and AV block II–III were compared between these groups. Ten year incidence rates and hazard ratios (HRs) were calculated by the Kaplan–Meier method and Cox regression analysis. Results Incidence rates of aortic regurgitation, AV block II–III, and AF in the r-axSpA group were 0.42, 0.21, and 4.0 per 1000 person-years, respectively. In the r-axSpA group, the SIR for aortic regurgitation was highest among 40–49-year-old men (4.11). Incidence rates of aortic regurgitation and AF were higher in the r-axSpA group than in the GP group (both p &lt; 0.001), whereas the difference was insignificant for AV block II–III. In multivariate analysis, HRs for aortic regurgitation and AF were higher in the r-axSpA group than in the GP group (HR (95% confidence interval) = 2.55 (1.49–4.37) and 1.20 (1.04–1.39), respectively), but the difference was insignificant for AV block II–III. Conclusion Compared with the GP, r-axSpA patients are at increased risk of aortic regurgitation and AF, but not AV block II–III. These patients should be carefully monitored for occurrence of aortic regurgitation and AF. References [1]Agca R, Heslinga SC, Rollefstad S, et al. EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update. Ann Rheum Dis 2017; 76: 17-28. [2]Szabo SM, Levy AR, Rao SR, et al. Increased risk of cardiovascular and cerebrovascular diseases in individuals with ankylosing spondylitis: a population-based study. Arthritis Rheum 2011; 63: 3294-3304. [3]Morovatdar N, Watts GF, Bondarsahebi Y, et al. Ankylosing Spondylitis and risk of Cardiac Arrhythmia and Conduction Disorders: A systematic review and meta analysis. Curr Cardiol Rev 2021. [4]Bengtsson K, Forsblad-d’Elia H, Lie E, et al. Risk of cardiac rhythm disturbances and aortic regurgitation in different spondyloarthritis subtypes in comparison with general population: a register-based study from Sweden. Ann Rheum Dis 2018; 77: 541-548. [5]Dik VK, Peters MJ, Dijkmans PA, et al. The relationship between disease-related characteristics and conduction disturbances in ankylosing spondylitis. Scand J Rheumatol 2010; 39: 38-41. Disclosure of Interests None declared