tbuckley/cabot-search huggingface dataset:
Calibration of a system for the computer-assisted operation of a small animal inhalation facility.
Authors: E W Van Stee, M P Moorman
Journal: Environmental Health Perspectives (1984)

The initialization of chambers in the computer-assisted inhalation facility at the National Institute of Environmental Health Sciences (1) includes a series of operations that we call "characterization." Characterization consists of two parts, the first of which is one of the topics of this report. In the first part of the characterization the mathematical relationship between the concentration of the chemical of interest and the output of the analyzer is approximated. This amounts to establishing a standard against which subsequent, daily calibrations can be compared. The second part of the characterization represents a wholly automatic operation in which certain dynamic characteristics of the system are quantified. A daily calibration is performed at the beginning of each day of chamber operation after the system has been characterized. The daily calibration data are checked against the characterization standard. The conversion equation for the daily operation of the chamber is derived from the daily calibration data combined with the characterization data. An equation that converts the output of the analyzer to units of concentration of the chemical of interest is at the heart of the computer-assisted monitoring and control system for our inhalation facility. The equation is derived from a calibration procedure that is conducted prior to starting each day's chamber operation. Quality control requires that, in addition to having a daily calibration of the system, a standard of reference be available against which each day's calibration data can be checked. This practice provides protection against the introduction of spurious calibration data on a daily basis, as well as providing a means for the detection of longer term drift.(ABSTRACT TRUNCATED AT 250 WORDS)
BOOK REVIEWS
Authors: S. F. HONIG
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article BOOK REVIEWS Get access Adjuvant Therapy of Breast Cancer I. Craig Henderson , ed . Boston : Kluwer Acad. Publ. , 1992 . 464 pp., illus. $170. ISBN 0-7923-1656-3 . SUSAN FLAMM HONIG, M.D. SUSAN FLAMM HONIG, M.D. Division of Medical Oncology, Georgetown University Medical Center3800 Reservoir Rd., N.W., Washington, DC 20007 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 10, 19 May 1993, Pages 828–829, https://doi.org/10.1093/jnci/85.10.828 Published: 19 May 1993
Crystal unclear
Authors: P K K Wong
Journal: Annals of the Rheumatic Diseases (2000)

<b>El-Gazzar, R., El-Sadik, Y. M., and Hussein, M. (1973).</b><i>British Journal of Industrial Medicine,</i><b>30,</b> 284-288. <b>Changes in zinc and serum proteins due to carbon disulphide exposure.</b> Serum zinc and proteins have been studied in 82 workers in the Egyptian rayon industry, of whom 40 were at the time exposed to carbon disulphide (CS<sub>2</sub>) and nine had been exposed in the past for a year or more. Thirty-three workers without exposure were used as controls. Carbon disulphide caused depletion of serum zinc by an increase in the rate of zinc excretion and an increase in all serum protein fractions. All these effects are temporary and improve on cessation of exposure.
Brief Physician Advice for Problem Drinkers
Authors: Katharine A. Bradley
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The trial of brief interventions for heavy drinking, reported by Dr Fleming and colleagues,<sup>1</sup>was impressive with respect to a number of methodological issues. However, I have several comments and questions about their report. First, the data presented regarding health care utilization seem potentially misleading. From the discussion, it appears that the investigators evaluated several measures of utilization based on patients' medical records and found no difference in utilization between the 2 groups (intervention and control). They also evaluated other health-related outcome measures, all of which showed no relationship to the intervention. Only data on patient reports of days hospitalized are presented, and presumably these were not statistically significant when analyzed for each follow-up time separately. The significant ϰ<sup>2</sup>value for a trend toward increased days hospitalized in the control group might be, in part, an artifact of multiple statistical comparisons. Bias also may have
New hazards for the newborn.
Journal: BMJ (1969)

PointersColonic Diverticular Disease: Review of natural history shows same prognosis in localized as in total involvement (p.639).Differential diagnosis best made on basis of combined clinical, radiological, and pathological data (p.642).Thyrotoxicosis: Double..blind crossover study shows-guanethidine eye drops valuable for lid retraction (p.645).Ketonuria in Diabetes: Significance may alter at different times of the day (p.648).Hypertension and Geography: Age-and-sex matched study of mean blood pressure levels shows apparently higher levels in Tiree com- pared with the mainland of Scotland (p.651).Mammography: Valuable accessory diagnostic role in diagnosis of breast lesions (p.655).Percutaneous Nephrostomy: Found to be safe, acceptable method for temporary drainage of obstructed kidney (p.657).Cytomegalovirus: Study from Rumania shows that subclinical viraemia not uncommon in blood donors (p.660).Myocardial Infarction: Temporary improvement in cardiogenic shock produced by glucagon injections ('p. 663).Leader at p. 635.Letter on general practitioners' role (p.690).Case Reports: Acute post-streptococcal toxaemic renal failure (p. 665).
Air Force School Celebrates "Supporting the Flier"
Authors: P. Gunby
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
After Chemo
Authors: Ronald Pies
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Equivalence of Generic and Brand-Name Drugs for Cardiovascular Disease
Authors: Barry L. Carter
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOME DIFFICULTIES IN THE DIAGNOSIS OF EMPYEMA COMPLICATING PNEUMONIA
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
latrogenic Gonorrhea?
Authors: Alan DeCherney
Journal: JAMA (1978)

<h3>To the Editor.—</h3> Attention should be drawn to a common practice in routine physicals and in prenatal clinics: first to examine the vagina and cervix with the rubber-gloved finger and then, without changing gloves, to do a rectal examination. Gonorrhea is, in most cases, a localized infection of the lower genital tract, and this type of examination provides a flagrant opportunity to introduce a gonococcal infection into the rectum. In prenatal and gynecologic clinics, the prevalence of cervical gonorrhea may be 1% to 7% and higher. Rectal gonorrhea is more resistant to treatment, and since the cost of changing gloves is small, there is little reason to prove or disprove the occurrence of such gonococcal transmissions. Depending on the clinical setting and the local prevalence of gonorrhea, it would seem advisable to switch gloves between a vaginal and a rectal examination.
Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome
Authors: Elisa Matas-Rico, Michiel van Veen, Daniela Leyton-Puig, Jeroen van den Berg, Jan Koster, Katarzyna M. Kedziora, Bas Molenaar, Marjolein J.A. Weerts, Iris de Rink, René H. Medema, Ben N.G. Giepmans, Anastassis Perrakis, Kees Jalink, Rogier Versteeg, Wouter H. Moolenaar
Journal: Cancer Cell (2016)

(Cancer Cell 30, 548–562; October 10, 2016) During the production process, the authors inadvertently replaced the Supplemental Information file with a version that was missing the Supplemental Experimental Procedures. The complete file, which includes the Supplemental Experimental Procedures section, is now available online. The authors apologize for this error and any confusion that it might have caused. Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical OutcomeMatas-Rico et al.Cancer CellSeptember 29, 2016In BriefMatas-Rico et al. show that GDE2 (encoded by GDPD5) promotes differentiation and suppresses motility of neuroblastoma (NB) cells through mechanisms involving glypican-6 release, activation of differentiation genes, Rac activation, and Rho inhibition. High GDPD5 expression in NB correlates with better prognosis. Full-Text PDF Open Access
Abuse of Medical Students-Reply
Authors: Henry K. Silver
Journal: JAMA (1982)

<h3>In Reply.—</h3> I appreciate and thank Mr Cattano and Drs White and West for their comments in response to my article. It should be stressed that the abuse about which I wrote is the abuse that is avoidable, unnecessary, and harmful. It is abuse inflicted by a person (or group of people) on another person (or group of people) and is not meant to pertain to the rigors of traditional medical education or to the situational stresses that appear to be inevitable in becoming a physician. The degree of medical student abuse and the response of students to the abuse undoubtedly vary widely. Although some students handle abuse well (or may not even notice that it is taking place), others are affected strongly by it at the time and may not overcome its effect for many years. My observations as well as those of many medical students and physicians, including
Upcoming Papers in the JACI
Authors: Eric Johnson, Kirk Druey, Mark Ballow, Stanley Szefler, Howard Eigen, Cristina Mapp, Anthony Fryer, Nicoletta De Marzo, Valeria Pozzato, Michele Padoan, Piera Boschetto, Richard Strange, Anja Hemmingsen, Monica Spiteri, Anneke Ten Brinke, Diana Grootendorst, Judith Schmidt, Francisca De Bruine, Mark Van Buchern, Peter Sterk, Klaus Rabe, Elisabeth Bel, Giovanni Pajno, Stefania Grutta, Giovanni Barberio, Giorgio Canonica, Gio- Vanni Passalacqua, Kirsten Beyer, Russell Castro, Audrey Birnbaum, Keith Benkov, Nanci Pittman, Hugh Sampson, New York, Jocelyne Just, Lydia Fournier, Isabelle Momas, Chiara Zambetti, Fathia Sahraoui, Alain Grimfeld, Robert Adams, Anne Fuhlbrigge, Jonathan Finkelstein, Scott Weiss, South Australia, Sun Ying, Yoko Kikuchi, Qiu Meng, A Kay, Allen Kaplan, Sang-Hoon Kim, Sun-Young Oh, Heung-Bum Oh, Yoon-Keun Kim, Sang-Heon Cho, You-Young Kim, Kyung-Up Min, Leanne Poulos, Timothy O'meara, Robert Hamilton, Euan Tovey, Sydney Australia
Journal: Journal of Allergy and Clinical Immunology (2002)
Surviving burns. Does early wound closure help?
Authors: C. M. Rinke
Journal: JAMA (1983)

Does early grafting of full-thickness (FT) burn wounds improve survival among the severely burned? Wolfe and colleagues present, in this issue ofThe Journal(p 763), an elegant mathematical model as evidence that early grafting is associated with improved survival. They have collected information on 12,000 patients entered from 11 national burn treatment centers, reporting burned body surface area, treatment, and outcome for each case. Like mathematical architects, Wolfe and associates generate two bodies of data and then correlate them. Phase 1 explicates computation of the standard mortality rate (SMR). From their burn registry data bank, the authors formulate a multiple logistic regression model to predict mortality in burn patients by assigning probabilities to several variables—burn wound size, age, sex, presence of perineal burn, and year of treatment. The sum of these probabilities in patients treated at one burn center yields "the expected number of deaths." The SMR compares the
Effect of recombinant human granulocyte macrophage‐colony stimulating factor in long‐term marrow cultures from patients with aplastic anemia
Authors: Guadalupe Martínez‐Jaramillo, Enrique Gómez‐Morales, Hector Mayani
Journal: American Journal of Hematology (1999)

The hematopoietic system in patients with aplastic anemia (AA) shows both quantitative and qualitative deficiencies, i.e., reduced numbers of hematopoietic progenitor cells (HPC) and impaired HPC proliferation in long-term marrow cultures (LTMC). Since recombinant human granulocyte macrophage-colony stimulating factor (rhGM-CSF) has been shown to be a potent stimulator of normal hematopoiesis, both in vivo and in vitro, in the present study we wanted to assess the possibility of stimulating hematopoiesis in LTMC from 17 patients with AA, by weekly addition of rhGM-CSF (10 ng/ml). In LTMC from 11 patients (group of responders), rhGM-CSF induced a significant increase (4.8-fold, compared with untreated cultures) in the levels of myeloid progenitor cells; in contrast, in six patients (group of nonresponders), myeloid progenitors were refractory to this cytokine. In the group of responders, rhGM-CSF also induced a pronounced increment in the levels of nonadherent and adherent cells (5.99- and 5.18-fold, respectively, compared with untreated cultures). Among the different myelopoietic lineages, rhGM-CSF preferentially stimulated the macrophagic lineage; this was evident both at the progenitor and mature cell levels. Interestingly, the effect of rhGM-CSF in LTMC from AA patients was only transient. Indeed, the effects mentioned above were observed only during the first three weeks of culture; afterwards, myeloid progenitor and nonadherent cell levels in treated cultures declined, practically reaching the levels observed in untreated cultures. At the moment, we do not know whether this transient stimulatory effect is due to the production of inhibitory cytokines, by macrophages generated in response to rhGM-CSF, or to the exhaustion of the HPC pool in AA cultures. In all 17 patients, rhGM-CSF had no effect on the kinetics of erythroid or multipotent progenitor cells. These results are in keeping with clinical studies in which it has been observed that most AA patients treated with rhGM-CSF show increments in circulating monocytes and granulocytes, as well as in bone marrow cellularity. However, little or no effect is observed on erythropoiesis. The actual mechanisms involved in the in vitro effects of rhGM-CSF on myeloid progenitor cells from AA bone marrow are still not completely understood. Future studies on this issue should be encouraged, since they may help to understand the in vivo (clinical) effects of this cytokine. Am. J. Hematol. 61:107–114, 1999. © 1999 Wiley-Liss, Inc.
Possible Stereotyping in a Personal Essay
Authors: W. Roy Smythe
Journal: Annals of Internal Medicine (2010)

Letters20 July 2010Possible Stereotyping in a Personal EssayW. Roy Smythe, MDW. Roy Smythe, MDFrom Scott & White Healthcare Temple Clinic, Temple, TX 76508.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-2-201007200-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I thank Dr. Scully for her comments and her expression of concern regarding stereotyping in “Mattie's Visit.”The supposed reference to the surgeon as a god in this piece, and its relation to the interaction with the grieving woman, requires a great deal of imagination—perhaps Dr. Scully is promoting a stereotypical depiction of a surgeon?The opening paragraph was simply an effort to describe the conflict that many physicians have when administrative life takes them away from patients. We miss our patients not for what we can pass down from Mount Olympus, but for what they teach us ... Author, Article, and Disclosure InformationAffiliations: From Scott & White Healthcare Temple Clinic, Temple, TX 76508.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMattie's Visit W. Roy Smythe Possible Stereotyping in a Personal Essay Janice M. Scully Metrics 20 July 2010Volume 153, Issue 2Page: 135KeywordsConflicts of interestSurgeons ePublished: 20 July 2010 Issue Published: 20 July 2010 CopyrightCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Biodehalogenation
Authors: C. E. Castro
Journal: Environmental Health Perspectives (1977)

Haloorganic biocides are widely employed as soil fumigants to combat the destructive action of plant parasitic nematodes and fungi. These substances are dehalogenated by soil organisms, principally species of Pseudomonas and Flavobacteria, to nontoxic metabolities. The paths of metabolism of a vareity of simply alkyl halides are described with emphasis upon the biodehalogenation step.
Frank Wright
Authors: I. Cooke
Journal: BMJ (2010)

<h3>Aim</h3> To understand the underlying pathology and antenatal, intrapartum and postnatal issues associated with Fanconi anaemia, and to appreciate the importance of care planning and MDT working. <h3>Discussion</h3> Described first in 1927, Fanconi anaemia is one of an autosomal recessive group of inherited bone marrow failure syndromes. It is characterised by dysmorphic features, pancytopenic bone marrow failure, and susceptibility to certain malignancies. It can be associated with delayed puberty, primary infertility and premature menopause, with limited data on pregnancy management. We present a case of a 23 year old primigravida with pre-existing Fanconi Anaemia. She was known to have severe thrombocytopenia and anaemia, both transfusion dependent. Despite relative stability pre-pregnancy her obstetric course was complicated by superimposed pre-eclampsia and worsening pancytopenia. Issues were further complicated by ceasing her pre-pregnancy androgens which had maintained her platelet count. Antenatal care was managed in a specialist joint haematology clinic with support from national centres and the local blood transfusion service. Additionally potential fetal implications of Fanconi anaemia were considered with the neonatology team. Considerable thought and planning was given to her mode of delivery and intrapartum blood product requirements. The risks and benefits of operative vs. vaginal delivery were debated, with elective Caesarean Section chosen. Post pregnancy follow up included detailed discussion of future contraception leading to hysteroscopic sterilisation. <h3>Conclusion</h3> Fanconi anaemia presents many fetal and maternal challenges to the management of pregnancy. Managing rare complex cases such as this not only requires detailed planning but also excellent inter-disciplinary team communication.