PB2458: CONSTRUCTION AND APPLICATION OF MULTI-DISCIPLINARY NUTRITION MANAGEMENT PLAN FOR MALNOURISHED PATIENTS AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION
Authors: Hengrui Sun, Xiaoli Chen, LI Wang, Xiaoqin Zhou, Yimei Feng, XI Zhang
Journal: HemaSphere (2023)

Topic: 22. Stem cell transplantation - Clinical Background: Hematopoietic stem cell transplantation (HSCT) is an effective method to treat and cure malignant hematological diseases. The 5-year survival rate of patients after operation can reach 80%. However, due to repeated infection, high body consumption and decreased appetite caused by drugs, the patients suffered from malnutrition before transplantation. This will increase the risk of transplantation and lead to postoperative complications such as infection and rejection. Early nutrition intervention can promote the recovery of intestinal function, improve immune and metabolic functions, and accelerate the recovery of transplant patients. Multi-disciplinary nutrition programs applied to cancer patients can improve their health, reduce complications and promote rapid recovery of patients. However, there is a lack of standardized and systematic perioperative multidisciplinary nutrition intervention program. In view of this, this study constructs a multidisciplinary nutrition management plan for transplant malnutrition patients, and applies it to transplant malnutrition patients. Aims: To construct a multi-disciplinary nutrition management program for patients with malnutrition after hematopoietic stem cell transplantation, and to explore the effect of this program on the nutritional status and rehabilitation effect of patients with malnutrition after hematopoietic stem cell transplantation. Methods: 119 patients with allo-HSCT admitted to our hospital from June 2020 to June 2022 were selected. According to the length of hospitalization, the patients with malnutrition before hematopoietic stem cell transplantation were divided into control group (59 cases) and intervention group (60 cases). The control group adopted routine nutrition management plan and diet guidance, and intervened to establish a nutrition intervention team to construct and implement a multidisciplinary nutrition management plan including sports prescription, nutrition prescription, drug treatment, psychological management, etc. Results: One month after hematopoietic stem cell transplantation, the levels of serum protein (ALB), serum total protein (TP) and hemoglobin (Hb) in the intervention group were significantly improved compared with those in the control group; Compared with the scores of the two groups in the NRS2002, the intervention group was less than 3 points, and the control group was between 4-5 points. The intervention group was significantly lower than the control group; The incidence of malnutrition and infection during transplantation in the observation group were significantly lower than those in the control group, and the postoperative hospital stay was significantly shorter than that in the control group. The treatment satisfaction rate was higher than that of the control group (P<0.05). Summary/Conclusion: Multi-disciplinary nutrition management is beneficial to improve the nutritional status of patients with preoperative malnutrition after hematopoietic stem cell transplantation and promote rehabilitation. Keywords: Hematopoietic cell transplantation