tbuckley/cabot-search huggingface dataset:
Firm Red-Brown Plaques in a Patient With Systemic Scleroderma
Authors: Natasha C. Zacher, Kerri E. Rieger, Elizabeth E. Bailey
Journal: JAMA Dermatology (2022)

A man in his 60s with systemic sclerosis complicated by scleroderma kidney crisis, heart failure, interstitial lung disease, sclerodactyly, and Raynaud phenomenon presented with a pruritic rash. What is your diagnosis?
Errors in Figure 2 and Table 3
Authors: Dong Kim, Soo Cho, Jin Jo, Jin Seong
Journal: JAMA Dermatology (2022)

Amy S. Paller, MD; Marieke M. B. Seyger, MD; Gabriel A. Magariños, MD; Andreas Pinter, MD; Jennifer C. Cather, MD; Claudia Rodriguez-Capriles, MD; Danting Zhu, PhD; Najwa Somani, MD; Alyssa Garrelts, PhD; Kim A. Papp, MD, PhD; IXORA-PEDS Investigators; Gabriel A. Magariños; Ricardo Galimberti; Diego Viola; Paula Luna; Charles Lynde; Danielle Marcoux; Vimal Prajapati; Ajith Cy; Petr Arenberger; Stanislava Polaskova; Hans Buckova; Jirina Bartonova; Petra Cetkovska; Jana Hercogova; Jean-Philippe Lacour; Alice Phan; Michael Sticherling; Petra Staubach-Renz; Margrit Simon; Andreas Pinter; Nina Magnolo; Piroska Dosa; Judit Noll; Eva Remenyik; Lajos Kemeny; Noemi Bakos; Claudia Bernabe del Rio; Mirna Toledo-Bahena; Minerva Gomez Flores; Zamira Barragan Estudillo; Marieke Seyger; Jolanta Weglowska; Elzbieta Szymanska; Andrzej Kaszuba; Nikolay Murashkin; Asuncion Vicente Villa; Raul L. Laguna; Raquel Rivera Diaz; Jerry Bagel; John Browning; Michael Bukhalo; Jennifer Cather; Alma Cruz Santana; Boni Elewski; Seth Forman; Jose Gonzalez-Chavez; Scott Gottlieb; Holly Hake Harris; Jessica Kaffenberger; Pearl Kwong; Sabre Leitenberger; Aida Lugo-Somolinos; Anna Kirkorian; Kari Martin; Amy Paller; David Pariser; Phoebe Rich; Adena Rosenblatt; Lucia Seminario-Vidal; Elaine Siegfried; Jeffrey Travers; Pedro Vendrell-Benito; Jamie Weisman; Lara Wine Lee; Matthew Zook; Samuel Sanches-Rivera; Vivian Laquer
Analysis of Cancer Survival Associated With Immune Checkpoint Inhibitors After Statistical Adjustment
Authors: Emily Pei-Ying Lin, Chih-Yuan Hsu, Lynne Berry, Paul Bunn, Yu Shyr
Journal: JAMA Network Open (2022)

Importance Appropriate clinical decision-making relies on accurate data interpretation, which in turn relies on the use of suitable statistical models. Long tails and early crossover—2 features commonly observed in immune checkpoint inhibitor (ICI) survival curves—raise questions as to the suitability of Cox proportional hazards regression for ICI survival analysis. Cox proportional hazards–Taylor expansion adjustment for long-term survival data (Cox-TEL) adjustment may provide possible solutions in this setting. Objective To estimate overall survival and progression-free survival benefits of ICI therapy vs chemotherapy using Cox-TEL adjustment. Data Sources A PubMed search was performed for all cataloged publications through May 22, 2022. Study Selection The search was restricted to randomized clinical trials with search terms for ICIs and lung cancer, melanoma, or urothelial carcinoma. The publications identified were further reviewed for inclusion. Data Extraction and Synthesis Cox proportional hazards ratios (HRs) were transformed to Cox-TEL HRs for patients with short-term treatment response (ie, short-term survivor) (ST-HR) and difference in proportions for patients with long-term survival (LT-DP) by Cox-TEL. Meta-analyses were performed using a frequentist random-effects model. Main Outcomes and Measures Outcomes of interest were pooled overall survival (primary outcome) and progression-free survival (secondary outcome) HRs, ST-HRs, and LT-DPs. Subgroup analyses stratified by cancer type also were performed. Results A total of 1036 publications was identified. After 3 levels of review against inclusion criteria, 13 clinical trials (7 in non–small cell lung cancer, 3 in melanoma, and 3 in urothelial carcinoma) were selected for the meta-analysis. In the primary analysis, pooled findings were 0.75 (95% CI, 0.70-0.81) for HR, 0.86 (95% CI, 0.81-0.92) for ST-HR, and 0.08 (95% CI, 0.06-0.10) for LT-DP. In the secondary analysis, the pooled values for progression-free survival were 0.77 (95% CI, 0.64-0.91) for HR, 1.02 (95% CI, 0.84-1.24) for ST-HR, and 0.10 (95% CI, 0.06-0.14) for LT-DP. Conclusions and Relevance This systematic review and meta-analysis of ICI clinical trial results noted consistently larger ST-HRs vs Cox HRs for ICI therapy, with an LT-DP of approximately 10%. These results suggest that Cox HRs may not provide a full picture of survival outcomes when the risk reduction from treatment is not constant, which may aid in the decision-making process of oncologists and patients.
Potential Limitations for the Culturally Tailored Version of Internet-Delivered Cognitive Behavioral Therapy for Insomnia in Black Women
Authors: Fan-Hsuan Kung, Mu-Hong Chen, Chih-Sung Liang
Journal: JAMA Psychiatry (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
American Association of Endocrine Surgeons Guidelines for Adrenalectomy
Authors: Linwah Yip, Quan-Yang Duh, Heather Wachtel, Camilo Jimenez, Cord Sturgeon, Cortney Lee, David Velázquez-Fernández, Eren Berber, Gary D. Hammer, Irina Bancos, James A. Lee, Jamie Marko, Lilah F. Morris-Wiseman, Marybeth S. Hughes, Masha J. Livhits, Mi-Ah Han, Philip W. Smith, Scott Wilhelm, Sylvia L. Asa, Thomas J. Fahey, Travis J. McKenzie, Vivian E. Strong, Nancy D. Perrier
Journal: JAMA Surgery (2022)

Adrenalectomy is the definitive treatment for multiple adrenal abnormalities. Advances in technology and genomics and an improved understanding of adrenal pathophysiology have altered operative techniques and indications.To develop evidence-based recommendations to enhance the appropriate, safe, and effective approaches to adrenalectomy.A multidisciplinary panel identified and investigated 7 categories of relevant clinical concern to practicing surgeons. Questions were structured in the framework Population, Intervention/Exposure, Comparison, and Outcome, and a guided review of medical literature from PubMed and/or Embase from 1980 to 2021 was performed. Recommendations were developed using Grading of Recommendations, Assessment, Development and Evaluation methodology and were discussed until consensus, and patient advocacy representation was included.Patients with an adrenal incidentaloma 1 cm or larger should undergo biochemical testing and further imaging characterization. Adrenal protocol computed tomography (CT) should be used to stratify malignancy risk and concern for pheochromocytoma. Routine scheduled follow-up of a nonfunctional adrenal nodule with benign imaging characteristics and unenhanced CT with Hounsfield units less than 10 is not suggested. When unilateral disease is present, laparoscopic adrenalectomy is recommended for patients with primary aldosteronism or autonomous cortisol secretion. Patients with clinical and radiographic findings consistent with adrenocortical carcinoma should be treated at high-volume multidisciplinary centers to optimize outcomes, including, when possible, a complete R0 resection without tumor disruption, which may require en bloc radical resection. Selective or nonselective α blockade can be used to safely prepare patients for surgical resection of paraganglioma/pheochromocytoma. Empirical perioperative glucocorticoid replacement therapy is indicated for patients with overt Cushing syndrome, but for patients with mild autonomous cortisol secretion, postoperative day 1 morning cortisol or cosyntropin stimulation testing can be used to determine the need for glucocorticoid replacement therapy. When patient and tumor variables are appropriate, we recommend minimally invasive adrenalectomy over open adrenalectomy because of improved perioperative morbidity. Minimally invasive adrenalectomy can be achieved either via a retroperitoneal or transperitoneal approach depending on surgeon expertise, as well as tumor and patient characteristics.Twenty-six clinically relevant and evidence-based recommendations are provided to assist surgeons with perioperative adrenal care.
Error in Figure and Results
Authors: Myong Lim, Boram Park, Sang-Yoon Park, S.-Y Lim
Journal: JAMA Surgery (2022)

Writing Group for the CODA Collaborative; Charles Parsons; Nathan I. Shapiro; Randall Cooper; Aleksandr Tichter; Ross Fleischman; Erin C. Howell; Dennis Kim; Brant Putnam; Lara H. Spence; Hikmatullah Arif; Farhood Farjah; Laura Hennessey; Kelsey Pullar; Erika Wolff; Lillian Adrianna Hayes; Alyssa Hayward; Joe H. Patton; Vance Sohn; Debra Burris; Damien Carter; Bruce Chung; Terilee Gerry; Joseph Mack; David MacKenzie; Hasan Alam; Nathan Haas; Cindy Hsu; Norman Olbrich; Pauline Park; Krishnan Raghavendran; Robert Bennion; Formosa Chen; Debbie Mireles; Gregory Moran; Kavitha Pathmarajah; Darin Saltzman; Lisandra Uribe; Paul J Schmit; Bruce Wolfe; Kimberly Deeney; Mary Guiden; Miriam Hernandez; Elliott Skopin; Heather VanDusen; Meridith Weiss; Careen Foster; Shaina Schaetzel; Brandon Tudor; Arden Morris; Ryan Martinez; Dayna Morgan; John Tschirhart; Julie Wallick; Sean Wells; Amy Rushing; Steven Steinberg; Mohamad Abouzeid; William Chiang; Jason Maggi; Marcovalerio Melis; Kristyn Pierce; Paresh Shah; Prashant Sinha; Brett Faine; Cathy Fairfield; Dionne Skeete; Deepti Patki; Rebekah K. Peacock; Donald M. Yealy; Karla Bernardi; Naila Dhanani; Tien C. Ko; Debbie Lew; Stephanie Marquez; Oscar Olavarria; Karen Horvath; Daniel Kim; Zoe Parr; Estel Williams; Karen F. Miller; Kelly M. Moser; Scott Osborn; Abigail Wiebusch; Julianna Yu; Karla Ballman; Sunday Clark; Billie Johnsson; Lauren Mount; Thomas Diflo; Kathleen O’Connor; Olga Owens; Giana H. Davidson, MD, MPH; Sarah E. Monsell, MS; Heather Evans, MD, MS; Emily C. Voldal, BA; Erin Fannon, BA; Sarah O. Lawrence, MA; Anusha Krishnadasan, PhD; David A. Talan, MD; Bonnie Bizzell, MBA, MEd; Patrick J. Heagerty, PhD; Bryan A. Comstock, MS; Danielle C. Lavallee, PharmD, PhD; Cassandra Villegas, MD, MPH; Robert Winchell, MD; Callie M. Thompson, MD; Wesley H. Self, MD, MPH; Lillian S. Kao, MD; Shah-Jahan Dodwad, DO; Amber K. Sabbatini, MD, MPH; David Droullard, MD; David Machado-Aranda, MD; Melinda Maggard Gibbons, MD; Amy H. Kaji, MD, PhD; Daniel A. DeUgarte, MD; Lisa Ferrigno, MD, MPH; Matthew Salzberg, MD; Katherine A. Mandell, MD, MPH; Nicole Siparsky, MD; Thea P. Price, MD; Anooradha Raman, MD; Joshua Corsa, MD; Jon Wisler, MD; Patricia Ayoung-Chee, MD, MPH; Jesse Victory, DO; Alan Jones, MD; Matthew Kutcher, MD; Karen McGrane, MD; Julie Holihan, MD; Mike K. Liang, MD; Joseph Cuschieri, MD; Jeffrey Johnson, MD; Katherine Fischkoff, MD; F. Thurston Drake, MD, MPH; Sabrina E. Sanchez, MD, MPH; Stephen R. Odom, MD; Larry G. Kessler, ScD; David R. Flum, MD, MPH
Awareness of SARS-CoV-2 Omicron Variant Infection Among Adults With Recent COVID-19 Seropositivity
Authors: Sandy Y. Joung, Joseph E. Ebinger, Nancy Sun, Yunxian Liu, Min Wu, Amber B. Tang, John C. Prostko, Edwin C. Frias, James L. Stewart, Kimia Sobhani, Susan Cheng
Journal: JAMA Network Open (2022)

Importance Some individuals who were infected by the SARS-CoV-2 Omicron variant may have been completely unaware of their infectious status while the virus was actively transmissible. Objective To examine awareness of infectious status among individuals during the recent Omicron variant surge in a diverse and populous urban region of Los Angeles County. Design, Setting, and Participants This cohort study analyzed the records of adult employees and patients of an academic medical center who were enrolled in a longitudinal COVID-19 serological study in Los Angeles County, California. These participants had 2 or more serial anti-nucleocapsid IgG (IgG-N) antibody measurements at least 1 month apart, with the first occurring after the end of a regional Delta variant surge (September 15, 2021) and a subsequent one occurring after the start of a regional Omicron variant surge (December 15, 2021). Adults with evidence of new SARS-CoV-2 infection occurring during the Omicron variant surge period through May 4, 2022, were included in the present study sample. Exposures Recent Omicron variant infection as evidenced by SARS-CoV-2 seroconversion. Main Outcomes and Measures Awareness of recent SARS-CoV-2 infection was ascertained from review of self-reported health updates, medical records, and COVID-19 testing data. Results Of the 210 participants (median [range] age, 51 (23-84) years; 136 women [65%]) with serological evidence of recent Omicron variant infection, 44% (92) demonstrated awareness of any recent Omicron variant infection and 56% (118) reported being unaware of their infectious status. Among those who were unaware, 10% (12 of 118) reported having had any symptoms, which they attributed to a common cold or other non–SARS-CoV-2 infection. In multivariable analyses that accounted for demographic and clinical characteristics, participants who were health care employees of the medical center were more likely than nonemployees to be aware of their recent Omicron variant infection (adjusted odds ratio, 2.46; 95% CI, 1.30-4.65). Conclusions and Relevance Results of this study suggest that more than half of adults with recent Omicron variant infection were unaware of their infectious status and that awareness was higher among health care employees than nonemployees, yet still low overall. Unawareness may be a highly prevalent factor associated with rapid person-to-person transmission within communities.
Proton Pump Inhibitors Associated With Drug-Induced Lupus Erythematosus
Authors: Pauline Bataille, Bénédicte Lebrun-Vignes, Florence Tubach, Marine Aroux-Pavard, Christelle Philibert, François Chasset, Annick Barbaud
Journal: JAMA Dermatology (2022)

This descriptive case series investigates the potential association between the use of proton pump inhibitors and drug-induced lupus erythematosus in cases reported in 2 large pharmacovigilance databases.
Comparison of Analgesic Prescriptions for Dental Pain and Patient Pain Outcomes Before vs After an Opioid Reduction Initiative
Authors: Qirong Huang, Linda Rasubala, Richard H. Gracely, Junad Khan, Eli Eliav, Yanfang Ren
Journal: JAMA Network Open (2022)

This cross-sectional study compares prescribing patterns of opioid and nonopioid analgesics and patients’ dental pain outcomes before vs after implementation of an opioid reduction initiative at a single dental clinic.
Much Anticipated Alzheimer Disease Prevention Trial Finds No Clinical Benefit From Drug Targeting Amyloid; Highlights Need to Consider Other Approaches
Authors: Rita Rubin
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Moving the Needle on Early Mortality After Injury—A Role for Liberalizing Prehospital Needle Decompression?
Authors: Hannah K. Holland, Daniel N. Holena
Journal: JAMA Surgery (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Long-term Effectiveness Associated With the BNT162b2 Vaccine Against SARS-CoV-2 Infection Among Adolescents in South Korea
Authors: Jia Kim, Young June Choe, Hyunju Lee, Eun Hwa Choi, Eun Jung Jang, Ryu Kyung Kim, Young-Joon Park
Journal: JAMA Network Open (2022)

This cohort study estimates the effectiveness associated with the BNT162b2 vaccine against infection and critical infection of SARS-CoV-2 among adolescents in South Korea.
Advances in Imaging and Targeted Therapies for Recurrent Pericarditis
Authors: Sachin Kumar, Shameer Khubber, Reza Reyaldeen, Ankit Agrawal, Paul C. Cremer, Massimo Imazio, Deborah H. Kwon, Allan L. Klein
Journal: JAMA Cardiology (2022)

Pericarditis is the most common form of pericardial disease. Recurrence of pericarditis affects 15% to 30% of patients after the initial episode of pericarditis. Up to 50% of patients with the first recurrence have additional recurrences. These patients often progress to have colchicine-resistant and corticosteroid-dependent disease. Rapidly evolving cardiac magnetic resonance imaging techniques and novel targeted therapies have paved the way for imaging-guided therapy for recurrent pericarditis. However, the optimal application of these recent advances remains unclear.A search was conducted using the PubMed and Cochrane databases for English-language studies, management guidelines, meta-analyses, and review articles published until April 2022 on recurrent pericarditis. Following the 2015 European Society of Cardiology guidelines for the diagnosis and management of pericardial diseases, new clinical trials and registry data have emerged that demonstrate the efficacy of interleukin-1 blockers in recurrent pericarditis. In addition, new observational data have come to light supporting the use of cardiac magnetic resonance imaging in the diagnosis, risk stratification, and management of such patients.Advances in imaging and targeted therapies have led to a paradigm shift in the management of recurrent pericarditis. This narrative review summarizes the established and emerging data on the diagnosis and treatment of recurrent pericarditis with special emphasis on the role of cardiac magnetic resonance imaging and interleukin-1 blockers in the current era of tailored therapy for recurrent pericarditis.
Importance of a Multidisciplinary and Comprehensive Approach to Management of Adrenal Tumors
Authors: Tracy S. Wang, Carmen C. Solórzano
Journal: JAMA Surgery (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Cytomegalovirus-vaccine-induced unconventional T cell priming and control of SIV replication is conserved between primate species
Authors: Daniel Malouli, Roxanne M. Gilbride, Helen L. Wu, Joseph M. Hwang, Nicholas Maier, Colette M. Hughes, Daniel Newhouse, David Morrow, Abigail B. Ventura, Lynn Law, Jennifer Tisoncik-Go, Leanne Whitmore, Elise Smith, Inah Golez, Jean Chang, Jason S. Reed, Courtney Waytashek, Whitney Weber, Husam Taher, Luke S. Uebelhoer, Jennie L. Womack, Matthew R. McArdle, Junwei Gao, Courtney R. Papen, Jeffrey D. Lifson, Benjamin J. Burwitz, Michael K. Axthelm, Jeremy Smedley, Klaus Früh, Michael Gale, Louis J. Picker, Scott G. Hansen, Jonah B. Sacha
Journal: Cell Host & Microbe (2022)
Carbon source availability drives nutrient utilization in CD8+ T cells
Authors: Irem Kaymak, Katarzyna M. Luda, Lauren R. Duimstra, Eric H. Ma, Joseph Longo, Michael S. Dahabieh, Brandon Faubert, Brandon M. Oswald, McLane J. Watson, Susan M. Kitchen-Goosen, Lisa M. DeCamp, Shelby E. Compton, Zhen Fu, Ralph J. DeBerardinis, Kelsey S. Williams, Ryan D. Sheldon, Russell G. Jones
Journal: Cell Metabolism (2022)

How environmental nutrient availability impacts T cell metabolism and function remains poorly understood. Here, we report that the presence of physiologic carbon sources (PCSs) in cell culture medium broadly impacts glucose utilization by CD8+ T cells, independent of transcriptional changes in metabolic reprogramming. The presence of PCSs reduced glucose contribution to the TCA cycle and increased effector function of CD8+ T cells, with lactate directly fueling the TCA cycle. In fact, CD8+ T cells responding to Listeria infection preferentially consumed lactate over glucose as a TCA cycle substrate in vitro, with lactate enhancing T cell bioenergetic and biosynthetic capacity. Inhibiting lactate-dependent metabolism in CD8+ T cells by silencing lactate dehydrogenase A (Ldha) impaired both T cell metabolic homeostasis and proliferative expansion in vivo. Together, our data indicate that carbon source availability shapes T cell glucose metabolism and identifies lactate as a bioenergetic and biosynthetic fuel for CD8+ effector T cells.