tbuckley/cabot-search huggingface dataset:
Pregnancy and Newborn Loss
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Shelter Dogs May Offer Clues to Chagas Disease Risk in Humans
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COMP-13. SILENCE OF HIPPO PATHWAY INDUCES PRO-TUMORAL IMMUNITY: NEW THERAPEUTIC TARGET OF GLIOBLASTOMAS
Authors: Eui Hyun Kim, Seok-Gu Kang, Ju-Seog Lee
Journal: Neuro-Oncology (2018)

The Hippo pathway plays a critical role in various cancers, but its role in glioblastoma (GBM) has not been properly addressed. To assess the clinical relevance of the Hippo pathway in GBM, we generated a core gene expression signature reflecting silence of the Hippo pathway (SOH), and validate it in GBM patient samples from The Cancer Genome Atlas (TCGA) and in a separate cohort revealing that SOH signature was associated with poor prognosis in GBM in both cohorts. Expression levels of CTGF and CYR61, the most reliable and well-known downstream targets of YAP1 (a target of the Hippo pathway), were markedly increased in GBM with the SOH signature. GBM showing the SOH signature was associated with an increased Immune signature score (ISS), suggesting that these patients might be good potential candidates for immunotherapy. Genes differentially expressed between samples with the SOH signature and samples with an active Hippo signature showed that many inhibitory immune checkpoint genes, such as CTLA4, PD-1, and PD-L2, were upregulated in the SOH subgroup, suggesting that YAP1/TAZ may induce resistance of cancer cells to host immune response in GBM. Also, many M2-polarized microglial markers and innate immune pathways were activated in the SOH subgroup. The SOH signature was strongly correlated with the TGF-β signature, which was also associated with a high ISS and mesenchymal features. In summary, SOH induces pro-tumoral immunity in various ways, which may be new immunotherapeutic targets of GBM.
Nutrition of the elderly.
Journal: BMJ (1968)

PointersPain in Arthritis: Probably the most intractable of all pains.Its management with drugs locally and systemically is described, though the patient's approach to life ard support he receives from his physician are as important (p.635).Po2 Measurements: Capillary blood taken from ear previously massaged with Trafuril gives values in close agreement with arterial Po. (p.640).Thyrotoxicosis: Out of 123 patients treated surgically 100 were euthyroid more than five years later.Twenty had some complication attributable to operation (p.643).Leader at p. 631.Mites and Dust: Dust mites found to be important in house dust allergies.Desensitiza- tion was successful in some cases (p.646).Tropical Neuropathy: Cause may be deficiency of sulphur-containing amino-acids resulting from release of cyanide from dietary cassava (p.647).Leader at p. 632.Friedreich's Ataxia: Heart failure was cause of death in more than half the patients in a series studied.Nearly three-quarters had evidence of cardiac dysfunction in life, and 23% had diabetes (p.649).Synthetic Corticotrophin: Asthmatic patients hypersensitive to animal corticotrophin had no allergic reaction to a synthetic preparation.Depot injection was effective for over 30 hours, compared with 20 hours for corticotrophin-gel (p.653).Ehlers-Danlos Syndrome: Lethal complica- tions (p.656).Case Reports: Hepatic artery aneurysm after endocarditis (p.659).Lippes Loop: Insertion by paramedical person- nel found practicable in West Indian study (p.671).Chest Radiography: Mobile service for general practitioners much appreciated (p.674).
Critical care medicine
Authors: J. G. Weg
Journal: JAMA (1989)

The prospective, randomized, double-blind, placebo-controlled clinical trial remains quintessential in resolving often complex, controversial clinical problems. Its importance is epitomized in the resolution of the decades-old debate over the role of corticosteroids in septic shock and in the adult respiratory distress syndrome (ARDS).<i>Corticosteroids do not help, and they may hurt</i>. The Veterans Administration Systemic Sepsis Cooperative Study Group<sup>1</sup>randomized patients with clinical signs of sepsis and a normal sensorium to receive methylprednisolone sodium succinate (30 mg/kg by intravenous bolus and then 5 mg/kg per hour for 9 hours) or placebo. One hundred twelve patients received the study drug and 111 served as controls. The average time between the diagnosis of sepsis and infusion was 2.8 hours. At 14 days, there was no difference in the main end point of mortality rates, which were 21% for the methylprednisolone group and 22% for the placebo group; nor was there any
Stimulant medications precipitate Tourette's syndrome
Authors: T. L. Lowe
Journal: JAMA (1982)

Following treatment with stimulant medications for symptoms of attention deficit disorder, Gilles de la Tourette's syndrome occurred in 15 patients. Early signs of Tourette's syndrome may be difficult to distinguish from hyperactive and attention disordered symptoms, leading the clinician to consider treatment with stimulants. In these Tourette's-susceptible patients, stimulants may exacerbate severe motor and phonic tics, requiring discontinuation of administration of stimulants and institution of haloperidol therapy for tic control. Clinical evaluation for tics and Tourette's syndrome in children and their families should precede and dictate use of stimulant medications in children. (<i>JAMA</i>1982;247:1168-1169)
Carving corneas for aphakic patients
Authors: P. Gunby
Journal: JAMA (1979)

Nongonococcal urethritis (NGU) now is being diagnosed in at least 2.5 million Americans per year, says the American Social Health Association. Some authorities suggest that NGU already is more common than gonorrhea in this country. In men with NGU,<i>Chlamydia trachomatis</i>is being recovered from the urethras of two or three of every five. It also is being found in the cervices of about two thirds of their female sexual partners. Among other complications, there is the possibility that inclusion conjunctivitis may develop in the infants of these women from exposure to the<i>C trachomatis</i>organism in the birth canal. In fact, additional problems may develop in exposed infants. University of California, San Francisco, investigator Chandler R. Dawson, MD, told a Research to Prevent Blindness seminar in Los Angeles this fall that "this chlamydial infection is the most common cause of pneumonia in newborns [two to six cases per 1,000
Alpha-fetoprotein in perspective
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physician Computer Network: Ad Gimmick or Efficiency Tool?-Reply
Authors: Neil H. Adelman
Journal: JAMA (1991)

<h3>In Reply.</h3> — Although Fahmy has communicated much of the basic information described in the PCN literature, I take exception to some of the questions and misperceptions raised. I am a practicing internist, one of the original PCN members, and an associate medical director for the company. Today's primary care physician works in an environment where income is more difficult to maintain and imposed administrative requirements increasingly compromise the ability to succeed financially. The PCN has provided my office with the means to maintain economic and professional independence. The concept of the PCN system is clearly "no free lunch" for the physician, nor is it offered that way. The physician is exchanging time, providing anonymous, aggregate information, and paying annual membership fees to participate in the network. These requirements provide physicians with the use of a sophisticated computer system for the office that improves cash flow, increases office productivity, and
Current practices in determining return to play following head injury in professional football
Authors: Jo Price
Journal: British Journal of Sports Medicine (2011)

Objective To investigate the awareness of English football team doctors of the ‘Consensus in Sport’ guidelines for the assessment and management of concussion. And to identify whether teams are following these recommendations and adhering to best practice. Method A questionnaire was sent to Club Medical Officers of all the 92 English Football league teams. Results The majority (55.6%) of teams in the English FA do not routinely follow the CIS guidelines. One third are still using outdated fixed periods of abstinence following a concussion. Conclusions FA players are not being treated at standards recommended by International sporting organisations. The endorsement of the CIS guidelines by the FA would ensure that all medical teams have a sound and safe protocol for managing concussed players and making return to play decisions.
Inhibition of Human Topoisomerase II in Vitro by Bioactive Benzene Metabolites
Authors: Christopher E. Frantz, Hongwei Chen, David A. Eastmond
Journal: Environmental Health Perspectives (1996)

Benzene is a clastogenic and carcinogenic agent that induces acute myelogenous leukemia in humans and multiple types of tumors in animals.Previous research has indicated that benzene must first be metabolized to one or more bioactive species to exert its myelotoxic and genotoxic effects.To better understand the possible role of individual benzene metabolites in the leuke- mogenic process, as well as to further investigate inhibition of topoisomerase 11 by benzene metabolites, a series of known and putative benzene metabolites, phenol, 4,4'-biphenol, 2,2'biphenol, hydroquinone, catechol, 1,2,4-benzenetriol, 1,4-benzoquinone, and trans-trans- muconaldehyde were tested for inhibitory effects in vitro on the human topoisomerase 11 enzyme.With minor modifications of the standard assay conditions, 1,4-benzoquinone and trans- trans-muconaldehyde were shown to be directly inhibitory, whereas all of the phenolic metabo- lites were shown to inhibit enzymatic activity following bioactivation using a peroxidase activation system.The majority of compounds tested inhibited topoisomerase 11 at concentrations at or below 10 pM.These results confirm and expand upon previous findings from our laboratory and indicate that many of the metabolites of benzene could potentially interfere with topoisomerase 11.Since other inhibitors of topoisomerase 11 have been shown to induce leukemia in humans, inhibition of this enzyme by benzene metabolites may also play a role in the carcinogenic effects of benzene.
AN INTRODUCTION TO THE STUDY OF PNEUMONIC FEVER.
Authors: EDWARD F. WELLS
Journal: JAMA (1889)

Pneumonic fever "is one of the severest, most common, and in cold and temperate climates, is productive of more deaths than any other acute disease," and "is, next to phthisis, the greatest enemy of mankind." The prevalence of a disease may be studied in various ways,<i>e. g.</i>, by considering; α. the annual mortality in relation (1) to the population, (2) to the deaths from all causes and (3) to the deaths from certain specified causes, and β. by comparing the annual mortality to (1) the population, (2) to that from all causes and (3) to that from specified causes. Pneumonic fever is responsible for an annual mortality of 1.27 per 1000 of population. This estimate differs somewhat from those arrived at by Sanders,31.38; Hirsch, 1.49; Ziemssen, 1.53, and Osterlen, 1.85. Inasmuch, however, as the magnitude of the figures with which I deal is much greater than that of either of
High-tech predicament: pulmonary artery catheter
Authors: R. C. Bone
Journal: JAMA (1990)

There have been few, if any, studies to evaluate physician interpretation and application of pulmonary artery catheter (PAC) data. The information presented in the article by Iberti et al<sup>1</sup>in this issue of<i>JAMA</i>is important to both intensivists and to all practitioners whose patients undergo these procedures. The authors document that "physician understanding of the use of the PAC is extremely variable and frighteningly low." Mean scores on their multiple-choice examination designed to measure knowledge about the PAC varied independently by training, frequency of use of PAC data in patient management, frequency of inserting a PAC, and whether the respondent's hospital was a primary medical school affiliate. There was an increase in correct responses with increased training and frequency of PAC use, but 47% of respondents to the questionnaire were unable to determine pulmonary capillary wedge pressure from a clear tracing. Furthermore, 44% of respondents could not correctly identify
Die Heliotherapie: Fünfundvierzigjährige Erfahrungen mit der Sonnenkur insbesondere bei der chirurgischen Tuberkulose
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: T.J. Harrist, A.K. Bhan, G.F. Murphy
Journal: British Journal of Dermatology (1983)

Journal Article Reply Get access T.J. Harrist, T.J. Harrist Dermatopathology Unit, Massachusetts General Hospital, Boston, Mass., U.S.A. Search for other works by this author on: Oxford Academic Google Scholar A.K. Bhan, A.K. Bhan Dermatopathology Unit, Massachusetts General Hospital, Boston, Mass., U.S.A. Search for other works by this author on: Oxford Academic Google Scholar G.F. Murphy G.F. Murphy Dermatopathology Unit, Massachusetts General Hospital, Boston, Mass., U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 108, Issue 6, 1 June 1983, Page 737, https://doi.org/10.1111/j.1365-2133.1983.tb01093.x Published: 01 June 1983
Leads from the MMWR. A strategic plan for the elimination of tuberculosis in the United States
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Video Comment on Saurabh Mukewar et al.
Journal: Endoscopy (2015)

See also: Endoscopically inserted nasobiliary catheters for high dose-rate brachytherapy as part of neoadjuvant therapy for perihilar cholangiocarcinomaEndoscopy 2015; 47(10): 878-883DOI: 10.1055/s-0034-1392044
Abstract 3183: Clinical Utility of 3-Dimensional Echocardiography in Evaluation of Severe Tricuspid Regurgitation Caused by Pacemaker or Implantable Cardioverter-Defibrillator Leads
Authors: Yoshihiro Seo, Tomoko Ishizu, Hideki Nakajima, Kiyoko Uno, Ryou Kawamura, Yukio Sekiguchi, Shigeyuki Watanabe, Iwao Yamaguchi, Kazutaka Aonuma
Journal: Circulation (2007)

Background. Pacemaker or implantable cardiovascular-defibrillator (ICD) leads may be a primary cause of symptomatic tricuspid regurgitation (TR). The aim of this study was to evaluate the utility of 3-dimensional echocardiography (3-DE) in identifying intracardiac routes of pacemaker or ICD leads in relation to TR. Methods. 3-DE examinations were performed to evaluate intracardiac lead routes from right atrium to ventricle and positions at the tricuspid valve in 73 patients: 53 patients with pacemaker and 20 patients with ICD. TR severity was assessed by 2-dimensional echocardiography and classified as mild, moderate, or severe based on the ratio of TR area to right atrium area. Results 3-DE identified the lead route and position at the tricuspid valve in 68 patients (93.1%). In the remaining 5 patients, an appropriate image could not be obtained due to artifacts caused by the lead. TR severity was classified as mild in 47 patients, moderate in 18 patients, and severe in 8 patients. In 7 of the 8 patients with severe TR, obstruction to tricuspid valve closing caused by the lead was identified (Figure ): obstruction of septal leaflet in 3 patients, posterior leaflet in 3 patients, and anterior leaflet in 1 patient. However, in all patients with mild to moderate TR, the lead was positioned at the annulus side between leaflets, and no closing obstruction was identified. Conclusion. 3DE can identify pacemaker or ICD lead route and position at the tricuspid valve and the obstruction to closing caused by the lead in patients with severe TR. Therefore, 3DE may be useful to evaluate the cause of severe TR in patients receiving a pacemaker or ICD.
Erratum: Cis-regulatory architecture of a brain signaling center predates the origin of chordates
Authors: Yao Yao, Paul J Minor, Ying-Tao Zhao, Yongsu Jeong, Ariel M Pani, Anna N King, Orsolya Symmons, Lin Gan, Wellington V Cardoso, François Spitz, Christopher J Lowe, Douglas J Epstein
Journal: Nature Genetics (2016)
Injuries Associated with Ultraviolet Tanning Devices — Wisconsin
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal