tbuckley/cabot-search huggingface dataset:
Change in Purpose in Life Before and After Onset of Cognitive Impairment
Authors: Angelina R. Sutin, Martina Luchetti, Yannick Stephan, Antonio Terracciano
Journal: JAMA Network Open (2023)

Purpose in life is a critical aspect of psychological well-being that is associated with better cognitive outcomes across the continuum of dementia. To our knowledge, the natural history of purpose with onset of cognitive impairment has yet to be evaluated.To evaluate changes in purpose in life prior to and after onset of cognitive impairment.This cohort study used assessments of purpose in life and cognitive status from March 2006 to May 2021 in the Health and Retirement Study (HRS) and from May 2011 to November 2021 in the National Health and Aging Trends Study (NHATS).Cognitive impairment at each wave based on established thresholds in HRS and NHATS.The main outcome was purpose in life, measured with the Ryff Measures of Psychological Well-Being in HRS and a validated item in NHATS.In HRS, 22 668 participants provided 50 985 assessments of purpose across all waves. In NHATS, 10 786 participants provided 53 880 assessments of purpose across all waves. In HRS, 58.3% of participants were female, with mean (SD) age of 64.76 (10.41) years at baseline; in NHATS, 57.4% were female, with mean (SD) age of 76.82 (7.71) years at baseline. Across waves, 6794 HRS participants (30%) and 4446 NHATS participants (41.2%) were in the cognitive impairment range. Accounting for demographic covariates and normative change in purpose, multilevel modeling indicated that standardized purpose in life declined significantly prior to onset of cognitive impairment (estimate for 10 years) in both HRS (b = -0.12; 95% CI, -0.17 to -0.07; P < .001) and NHATS (b = -0.10; 95% CI, -0.20 to -0.01; P = .03). Purpose declined significantly more rapidly following onset of cognitive impairment, with a standardized decline nearly 3 times larger compared with prior to impairment in HRS (b = -0.35; 95% CI, -0.41 to -0.29; P < .001) and 4 times larger in NHATS (b = -0.44; 95% CI, -0.53 to -0.34; P < .001).In this cohort study, purpose in life declined with emergence of cognitive impairment. The decline before onset was too small to be useful to detect impending impairment in clinical settings. The steeper decline following impairment suggests that individuals are aware that their purpose is declining. Purpose may be an intervention target following cognitive impairment to maintain well-being and to reduce or slow emergence of behavioral symptoms associated with low purpose.
Multifunctional Hydrogels for the Healing of Diabetic Wounds
Authors: Tao Xiang, Qianru Guo, Lianghao Jia, Tianyu Yin, Wei Huang, Xinyu Zhang, Shaobing Zhou
Journal: Advanced Healthcare Materials (2023)

Abstract The healing of diabetic wounds is hindered by various factors, including bacterial infection, macrophage dysfunction, excess proinflammatory cytokines, high levels of reactive oxygen species, and sustained hypoxia. These factors collectively impede cellular behaviors and the healing process. Consequently, this review presents intelligent hydrogels equipped with multifunctional capacities, which enable them to dynamically respond to the microenvironment and accelerate wound healing in various ways, including stimuli ‐responsiveness, injectable self‐healing, shape ‐memory, and conductive and real‐time monitoring properties. The relationship between the multiple functions and wound healing is also discussed. Based on the microenvironment of diabetic wounds, antibacterial, anti‐inflammatory, immunomodulatory, antioxidant, and pro‐angiogenic strategies are combined with multifunctional hydrogels. The application of multifunctional hydrogels in the repair of diabetic wounds is systematically discussed, aiming to provide guidelines for fabricating hydrogels for diabetic wound healing and exploring the role of intelligent hydrogels in the therapeutic processes.
Adagrasib's Efficacy Sustained in <i>KRAS</i>G12C NSCLC
Journal: Cancer Discovery (2023)

Abstract According to the latest update from KRYSTAL-1, adagrasib shows durable efficacy in patients with advanced, previously treated KRASG12C non–small cell lung cancer. At 2 years, approximately one in three patients were still alive, and no new toxicities emerged, indicating that the KRASG12C inhibitor's long-term safety is manageable.
The guanine nucleotide exchange factor Rin-like controls Tfh cell differentiation via CD28 signaling
Authors: Lisa Sandner, Marlis Alteneder, Ramona Rica, Barbara Woller, Eleonora Sala, Tobias Frey, Anela Tosevska, Ci Zhu, Moritz Madern, Matarr Khan, Pol Hoffmann, Alexandra Schebesta, Ichiro Taniuchi, Michael Bonelli, Klaus Schmetterer, Matteo Iannacone, Mirela Kuka, Wilfried Ellmeier, Shinya Sakaguchi, Ruth Herbst, Nicole Boucheron
Journal: The Journal of Experimental Medicine (2023)

T follicular helper (Tfh) cells are essential for the development of germinal center B cells and high-affinity antibody-producing B cells in humans and mice. Here, we identify the guanine nucleotide exchange factor (GEF) Rin-like (Rinl) as a negative regulator of Tfh generation. Loss of Rinl leads to an increase of Tfh in aging, upon in vivo immunization and acute LCMV Armstrong infection in mice, and in human CD4+ T cell in vitro cultures. Mechanistically, adoptive transfer experiments using WT and Rinl-KO naïve CD4+ T cells unraveled T cell-intrinsic GEF-dependent functions of Rinl. Further, Rinl regulates CD28 internalization and signaling, thereby shaping CD4+ T cell activation and differentiation. Thus, our results identify the GEF Rinl as a negative regulator of global Tfh differentiation in an immunological context and species-independent manner, and furthermore, connect Rinl with CD28 internalization and signaling pathways in CD4+ T cells, demonstrating for the first time the importance of endocytic processes for Tfh differentiation.
Supervised exercise training in patients with advanced heart failure and left ventricular assist device: A multicentre randomized controlled trial (<scp>Ex‐VAD</scp> trial)
Authors: Anna Feuerstein, Felix Schoenrath, Evgeny Belyavskiy, Jan Knierim, Tim Friede, Marius Placzek, Doris Bach, Elisabeth Pieske‐Kraigher, Christoph Herrmann‐Lingen, Ralf Westenfeld, Michael Roden, Meike Rybczynski, Nicolas Verheyen, Marcus Dörr, Stephan von Haehling, Stefan Störk, Martin Halle, Volkmar Falk, Burkert Pieske, Frank Edelmann
Journal: European Journal of Heart Failure (2023)

Aims Small studies and observations suggested that exercise training may improve peak oxygen consumption (peakVO 2 ) in patients with advanced heart failure and left ventricular assist device (LVAD). We investigated whether in this patient group a supervised exercise training can improve exercise capacity. Methods and results In this multicentre, prospective, randomized, controlled trial, patients with stable heart failure and LVAD were randomly assigned (2:1) to 12 weeks of supervised exercise training or usual care, with 12 weeks of follow‐up. The primary endpoint was the change in peakVO 2 after 12 weeks (51 patients provided a power of 90% with an expected group difference in peakVO 2 of 3 ml/kg/min). Secondary endpoints included changes in submaximal exercise capacity and quality of life. Among 64 patients enrolled (97% male, mean age 56 years), 54 were included in the analysis. Mean difference in the change of peakVO 2 after 12 weeks was 0.826 ml/min/kg (95% confidence interval [CI] −0.37, 2.03; p = 0.183). There was a positive effect of exercise training on 6‐min walk distance with a mean increase in the intervention group by 43.4 m (95% CI 16.9, 69.9; p = 0.0024), and on the Kansas City Cardiomyopathy Questionnaire physical domain score (mean 14.3, 95% CI 3.7, 24.9; p = 0.0124), both after 12 weeks. The overall adherence was high (71%), and there were no differences in adverse events between groups. Conclusion In patients with advanced heart failure and LVAD, 12 weeks of exercise training did not improve peakVO 2 but demonstrated positive effects on submaximal exercise capacity and physical quality of life.
Pediatric Cervical Spine Injury Following Blunt Trauma in Children Younger Than 3 Years
Authors: Casey M. Luckhurst, Holly M. Wiberg, Rebeccah L. Brown, Steven W. Bruch, Nicole M. Chandler, Paul D. Danielson, John M. Draus, Mary E. Fallat, Barbara A. Gaines, Jeffrey H. Haynes, Kenji Inaba, Saleem Islam, Stephen S. Kaminski, Hae Sung Kang, Vashisht V. Madabhushi, Jason Murray, Michael L. Nance, Faisal G. Qureshi, Jeanne Rubsam, Steven Stylianos, Dimitris J. Bertsimas, Peter T. Masiakos
Journal: JAMA Surgery (2023)

There is variability in practice and imaging usage to diagnose cervical spine injury (CSI) following blunt trauma in pediatric patients.
Autoimmune disease and the risk of anal cancer in the US population aged 66 years and over
Authors: Minkyo Song, Eric A Engels, Megan A Clarke, Aimée R Kreimer, Meredith S Shiels
Journal: JNCI Journal of the National Cancer Institute (2023)

In the United States, anal squamous cell carcinoma rates have increased rapidly, particularly among women 50 or older than 66 years of age. As immunosuppression is associated with increased risk, autoimmune conditions may be associated with greater risk of anal squamous cell carcinoma.
Region-specific protection effect of preoperative oral antibiotics combined with mechanical bowel preparation before laparoscopic colorectal resection: a prospective randomized controlled trial
Authors: Purun Lei, Guiru Jia, Xiaofeng Yang, Ying Ruan, Bo Wei, Tufeng Chen
Journal: International Journal of Surgery (2023)

Oral antibiotics (OA) combined with mechanical bowel preparation (MBP) significantly decrease the rate of surgical site infections (SSIs). However, the prophylactic effects in region-specific colorectal surgery have not been assessed.
Evaluating Neighborhood-Level Differences in Hair Product Safety by Environmental Working Group Ratings among Retailers in Boston, Massachusetts
Authors: Marissa Chan, Shivani Parikh, Derek Shyr, Bhavna Shamasunder, Gary Adamkiewicz, Tamarra James-Todd
Journal: Environmental Health Perspectives (2023)

Personal care products are a notable source of exposure to endocrine-disrupting chemicals (EDCs). Racial/ethnic differences in the use of hair products containing EDCs are reported, with women and children of color more commonly using hair products that are hormonally active and contain EDCs than other racial/ethnic groups. There is limited research examining the neighborhood-level social and economic factors that may contribute to these reported disparities.
Fractional Flow Reserve–Negative High-Risk Plaques and Clinical Outcomes After Myocardial Infarction
Authors: Jan-Quinten Mol, Rick H. J. A. Volleberg, Anouar Belkacemi, Renicus S. Hermanides, Martijn Meuwissen, Alexey V. Protopopov, Peep Laanmets, Oleg V. Krestyaninov, Robert Dennert, Rohit M. Oemrawsingh, Jan-Peter van Kuijk, Karin Arkenbout, Dirk J. van der Heijden, Saman Rasoul, Erik Lipsic, Laura Rodwell, Cyril Camaro, Peter Damman, Tomasz Roleder, Elvin Kedhi, Maarten A. H. van Leeuwen, Robert-Jan M. van Geuns, Niels van Royen
Journal: JAMA Cardiology (2023)

Even after fractional flow reserve (FFR)-guided complete revascularization, patients with myocardial infarction (MI) have high rates of recurrent major adverse cardiovascular events (MACE). These recurrences may be caused by FFR-negative high-risk nonculprit lesions.
Error in Text
Journal: JAMA Surgery (2023)

In the Research Letter titled "Internet Searches for Self-Managed Abortion After RoevWadeOverturned" 1 published online July 5, 2023, there was an error in the second sentence of the Results section.The sentence should be as follows: "In states where abortion is illegal vs legal, there was a greater number of searches for abortion-related phrases."This article has been corrected online.
Many Medicaid Enrollees Do Not Receive Needed HIV Care
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
More Cancer in People Younger Than 50 Years
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Etiologic Studies of Premenstrual Disorders Require Prospective Confirmation of Affective Cyclicity
Authors: Arianna Di Florio, Chloe Apsey, Tory A. Eisenlohr-Moul
Journal: JAMA Psychiatry (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Risk of Multiple Primary Cancers in Patients With Merkel Cell Carcinoma
Authors: Edward Eid, Nolan J. Maloney, Zhuo Ran Cai, Lisa C. Zaba, Nour Kibbi, Esther M. John, Eleni Linos
Journal: JAMA Dermatology (2023)

The risk of subsequent primary cancers after a diagnosis of cutaneous Merkel cell carcinoma (MCC) is not well established.
Assessing the association between genetic and phenotypic features of dilated cardiomyopathy and outcome in patients with coronary artery disease
Authors: Richard E. Jones, Daniel J. Hammersley, Sean Zheng, Kathryn A. McGurk, Antonio de Marvao, Pantazis I. Theotokis, Ruth Owen, Upasana Tayal, Gillian Rea, Suzan Hatipoglu, Rachel J. Buchan, Lukas Mach, Lara Curran, Amrit S. Lota, François Simard, Rohin K. Reddy, Suprateeka Talukder, Won Young Yoon, Ali Vazir, Dudley J. Pennell, Declan P. O'Regan, A. John Baksi, Brian P. Halliday, James S. Ware, Sanjay K. Prasad
Journal: European Journal of Heart Failure (2023)

To examine the relevance of genetic and cardiovascular magnetic resonance (CMR) features of dilated cardiomyopathy (DCM) in individuals with coronary artery disease (CAD).
A commentary on ‘The role of rapid intraoperative parathyroid hormone (ioPTH) assay in determining outcome of parathyroidectomy in primary hyperparathyroidism: A systematic review and meta-analysis’
Authors: Xin Li, Hongping Gu, Xiaolin Wu
Journal: International Journal of Surgery (2023)

aDepartment of Internal Medicine, Yuyao Hospital of Traditional Chinese Medicine, Zhejiang, China, 315400 bDepartment of Oncology, Shaoxing Shangyu People's Hospital, Zhejiang, China, 312300 Data are publicly available. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Internal Medicine, Yuyao Hospital of Traditional Chinese Medicine, Zhejiang, China, 315400. E-mail address: [email protected] (X. Li). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Multifunctional Nanofibrous Scaffolds Capable of Localized Delivery of Theranostic Nanoparticles for Postoperative Cancer Management
Authors: Lin Guo, Qilong Zhao, Li‐wu Zheng, Min Wang
Journal: Advanced Healthcare Materials (2023)

Postoperative recovery of cancer patients can be affected by complications, such as tissue dysfunction or disability caused by tissue resection, and also cancer recurrence resulting from residual cancer cells. Despite impressive progress made for tissue engineering scaffolds that assist tissue regeneration for postoperative cancer patients, the majority of existing tissue engineering scaffolds still lack functions for monitoring and killing residual cancer cells, if there are any, upon their detection. In this study, multifunctional scaffolds that comprise biodegradable nanofibers and core-shell structured microspheres encapsulated with theranostic nanoparticles (NPs) are developed. The multifunctional scaffolds possess an extracellular matrix-like nanofibrous architecture and soft tissue-like mechanical properties, making them excellent tissue engineering patch candidates for assisting in the repair and regeneration of tissues at the cancerous sites after surgery. Furthermore, they are capable of localized delivery of theranostic NPs upon quick degradation of core-shell structured microspheres that contain theranostic NPs. Leveraging on folic acid-mediated ligand-receptor binding, surface-enhanced Raman scattering activity, and near-infrared-responsive photothermal effect of the theranostic gold NPs (AuNPs) delivered locally, the multifunctional scaffolds display excellent active targeting, diagnosis, and photothermal therapy functions for cancer cells, showing great promise for adaptive postoperative cancer management.
Improvement in Lung Clearance Index and Chest Computed Tomography Scores with Elexacaftor/Tezacaftor/Ivacaftor Treatment in People with Cystic Fibrosis Aged 12 Years and Older – The RECOVER Trial
Authors: Paul McNally, Karen Lester, Gavin Stone, Basil Elnazir, Michael Williamson, Des Cox, Barry Linnane, Laura Kirwan, David Rea, Paul O’Regan, Tom Semple, Clare Saunders, Harm A.W.M. Tiddens, Edward McKone, Jane C. Davies, Colin Lewis, Thara Persaud, Aisling McQuaid, Eilish Twomey, Aideen Lambe, Johnathan Dodd, Christopher Short, Damian Downey, Karen Keown, Benat Broderick, Caroline Heffernan, Carolyn Thornton
Journal: American Journal of Respiratory and Critical Care Medicine (2023)

Clinical trials have shown that use of elexacaftor/tezacaftor/ivacaftor (ETI) is associated with improvements in sweat chloride, pulmonary function, nutrition, and quality of life in people with cystic fibrosis (CF). Little is known about the impact of ETI on ventilation inhomogeneity and lung structure.
Simultaneous vs Staged Cardiac Intervention in High-Acuity Liver Transplant
Authors: Julian K. Horwitz, Daisuke Noguchi, Samer Ebaid, Peyman Benharash, Henry Honda, Douglas G. Farmer, Fady M. Kaldas
Journal: JAMA Surgery (2023)

This cohort study examines mortality, survival, and other outcomes among adults who underwent combined cardiac surgery and liver transplant, coronary revascularization prior to liver transplant, or isolated liver transplant.
Dialectical Behavior Therapy for Adolescents With Bipolar Disorder
Authors: Tina R. Goldstein, John Merranko, Noelle Rode, Raeanne Sylvester, Nina Hotkowski, Rachael Fersch-Podrat, Danella M. Hafeman, Rasim Diler, Dara Sakolsky, Peter Franzen, Boris Birmaher
Journal: JAMA Psychiatry (2023)

Early-onset bipolar disorder conveys substantial risk for suicide. No psychosocial intervention for this population expressly targets suicidal behavior.
Circulating Tumor DNA Monitoring on Chemo-immunotherapy for Risk Stratification in Advanced Non–Small Cell Lung Cancer
Authors: Bruna Pellini, Russell W. Madison, Merrida A. Childress, Shoshana T. Miller, Ole Gjoerup, Jason Cheng, Richard S.P. Huang, Michael Krainock, Pratyush Gupta, Wei Zou, David S. Shames, Solomon Moshkevich, Marcus Ballinger, Minetta C. Liu, Amanda Young, Minu K. Srivastava, Geoffrey R. Oxnard, Mark A. Socinski
Journal: Clinical Cancer Research (2023)

Abstract Purpose: Chemoimmunotherapy (chemoIO) is a prevalent first-line treatment for advanced driver-negative non–small cell lung cancer (NSCLC), with maintenance therapy given after induction. However, there is significant clinical variability in the duration, dosing, and timing of maintenance therapy after induction chemoIO. We used circulating tumor DNA (ctDNA) monitoring to inform outcomes in patients with advanced NSCLC receiving chemoIO. Experimental Design: This retrospective study included 221 patients from a phase III trial of atezolizumab+carboplatin+nab-paclitaxel versus carboplatin+nab-paclitaxel in squamous NSCLC (IMpower131). ctDNA monitoring used the FoundationOne Tracker involving comprehensive genomic profiling of pretreatment tumor tissue, variant selection using an algorithm to exclude nontumor variants, and multiplex PCR of up to 16 variants to detect and quantify ctDNA. Results: ctDNA was detected (ctDNA+) in 96% of pretreatment samples (median, 93 mean tumor molecules/mL), and similar ctDNA dynamics were noted across treatment arms during chemoIO. ctDNA decrease from baseline to C4D1 was associated with improved outcomes across multiple cutoffs for patients treated with chemoIO. When including patients with missing plasma or ctDNA- at baseline, patients with ctDNA- at C4D1 (clearance), had more favorable progression-free survival (median 8.8 vs. 3.5 months; HR, 0.32;0.20–0.52) and OS (median not reached vs. 8.9 months; HR, 0.22; 0.12–0.39) from C4D1 than ctDNA+ patients. Conclusions: ctDNA monitoring during induction chemoIO can inform treatment outcomes in patients with advanced NSCLC. Importantly, monitoring remains feasible and informative for patients missing baseline ctDNA. ctDNA testing during induction chemoIO identifies patients at higher risk for disease progression and may inform patient selection for novel personalized maintenance or second-line treatment strategies.