tbuckley/cabot-search huggingface dataset:
Encephalitis: A Clinical Study
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diphenylhydantoin Control of Alcohol Withdrawal Seizures
Authors: Richard Sampliner
Journal: JAMA (1974)

Diphenylhydantoin (300 mg/day) or placebo was "blindly" administered for five days to 157 patients entering an alcoholism detoxification unit; all patients received sedative doses of chlordiazepoxide. All patients had a history of convulsions in adulthood. Eleven patients in the placebo-treated group but none in the diphenylhydantoin group had convulsions in the first 48 hours. Two patients had convulsions after withdrawal of active drug. Blood levels of diphenylhydantoin were determined in 18 alcoholics and in five normal subjects. Comparable blood levels (3μg/ml) were obtained in both groups after the first day and reached a plateau of 4μg/ml after the third. (<i>JAMA</i>230:1430-1432, 1974)
Mechanisms of Contraction of the Normal and Failing Heart
Authors: Eugene Braunwald, John Ross, Edmund H. Sonnenblick
Journal: New England Journal of Medicine (1967)

Myocardial Mechanics and HemodynamicsSpann et al.227 recently compared the intrinsic contractile state of myocardium removed from normal, hypertrophied and failing hearts. Constriction of the pulmonary artery was carried out in cats, and papillary muscles removed from the right ventricles of animals in which either right ventricular hypertrophy or overt right ventricular failure had developed, and the removed muscles were then studied in vitro. Both right ventricular hypertrophy and heart failure reduced the maximum velocity of shortening (V max ) as well as the development of maximum isometric tension (P 0 ) below the values observed in muscles obtained from . . .
STUDIES ON CHRONIC MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS WITH HYPOCOMPLEMENTEMIA
Authors: Alfred F. Michael, N. Gunnar Westberg, Alfred J. Fish, Robert L. Vernier
Journal: The Journal of Experimental Medicine (1971)

CMPGN with hypocomplementemia appears to be one identifiable form of progressive and destructive glomerulonephritis, but whether this is a specific pathogenetic entity has not been proven. The clinical features of the "disease" include presentation with either asymptomatic proteinuria and hematuria, nephrotic syndrome, or gross hematuria and an acute nephritic syndrome. Morphologic studies reveal extensive mesangial cell proliferation and increased matrix with thickening of the glomerular capillary. Deposits of C3 and properdin uniformly are found predominantly in a peripheral lobular distribution by immunofluorescent microscopy; immunoglobulins are seen less consistently. These deposits are different from those seen in other glomerular diseases. Serum complement abnormalities have also been demonstrated: depression of C3t (and ß1C/ß1A) with relatively normal earlier components, evidence for in vivo breakdown of C3 by labeled isotope studies and elevated α2D, presence of a serum inhibitor that inactivates guinea pig C3t and a pseudoglobulin lytic factor that in combination with a normal serum cofactor enzymatically cleaves C3 to α2D and ß1A. The terminal complement inactivation and the uniform presence of properdin in these deposits suggesting an alternate pathway of immune injury must be balanced against immunopathologic observations which demonstrate glomerular deposits of immunoglobulins and earlier complement components. It is possible that both mechanisms may be operative in CMPGN.
Highlights of This Issue
Journal: Clinical Cancer Research (2010)

Sulforaphane is a natural compound derived from broccoli and previously has been shown to possess chemopreventive properties. In this issue, Li and colleagues found that sulforaphane can inhibit breast cancer stem cells in vitro and in vivo. In a mammosphere formation assay, sulforaphane significantly reduced the size and number of primary mammospheres. Further, sulforaphane was able to reduce the numbers of breast cancer stem cells in a mouse xenograft tumor model. Downregulation of the Wnt/β-catenin self-renewal pathway was observed in cells treated with sulforaphane. These findings provide rationale for future clinical evaluation of sulforaphane for breast cancer chemoprevention.EphA2 is frequently overexpressed in endometrial cancers and is a promising target for molecular delivery of cytotoxic agents. Lee and colleagues tested the antibody drug conjugate MEDI-547, composed of a fully human monoclonal antibody against EphA2 and the tubulin polymerization inhibitor monomethylauristatin F, in endometrial cancer. They found that MEDI-547 specifically bound to and was internalized by EphA2-positive endometrial cancer cells. Further, in vitro assays demonstrated that MEDI- 547 decreased viability and increased apoptosis of endometrial cancer cell lines. Finally, in vivo therapy experiments with MEDI-547 resulted in significant antitumor activity in EphA2-positive orthotopic mouse models of uterine carcinoma.The clinical course of follicular lymphoma (FL) has been associated with molecular signatures reflecting putative interactions between tumor cells and infiltrating immune cells, and the prognostic significance of the microenvironment may depend on chemotherapy type. Here, Taskinen and colleagues used a combination of gene expression profiling, immunohistochemistry, and cellular studies to identify signaling pathways that mediate crosstalk between lymphoma cells and tumor-infiltrating inflammatory cells and that may contribute to the outcome of FL patients treated with R-CHOP immunochemotherapy. Their results provide evidence that STAT5a pathway signaling in immunologically active neighboring nonmalignant cells may predict therapy efficacy in R-CHOP–treated patients.Preclinical studies have suggested favorable antitumor interactions between paclitaxel and trabectedin. Here, Chu and colleagues performed a phase I study of paclitaxel and trabectedin in patients with refractory solid malignancies. The maximum tolerated dose (MTD) levels of sequential paclitaxel (1-hour infusion, day 1) and trabectedin (3-hour infusion, day 2) administered every 2 weeks were determined to be 120 mg/m2 and 0.650 mg/m2, respectively. Several patients had stable disease as their best response. Since protracted administration of paclitaxel and trabectedin at the MTD level was demonstrated to be well tolerated and feasible, it is recommended for subsequent disease-directed studies.
Children and parasuicide
Authors: R B Crossley
Journal: BMJ (1981)

Twenty years ago Canetti observed that "drug resistance is a function of the quality of chemotherapy which can be applied . . . it is a problem of drug activity and drug acceptability.For many nations it is also a problem of cost."15The same is true today.Pyle MM.Relative numbers of resistant tubercle bacilli in sputa of patients before and during treatment with streptomycin.
Rifamycin Derivatives Strongly Inhibiting RNA→DNA Polymerase (Reverse Transcriptase) of Murine Sarcoma Viruses
Authors: Gurgo, Corrado, Ray, Ranjit, Green, Maurice
Journal: JNCI Journal of the National Cancer Institute (1972)

Journal Article Rifamycin Derivatives Strongly Inhibiting RNA→DNA Polymerase (Reverse Transcriptase) of Murine Sarcoma Viruses Get access Corrado Gurgo, Corrado Gurgo Institute for Molecular Virology, St. Louis University School of Medicine, St. Louis, Missouri 63110 Search for other works by this author on: Oxford Academic PubMed Google Scholar Ranjit Ray, Ranjit Ray Institute for Molecular Virology, St. Louis University School of Medicine, St. Louis, Missouri 63110 Search for other works by this author on: Oxford Academic PubMed Google Scholar Maurice Green Maurice Green Institute for Molecular Virology, St. Louis University School of Medicine, St. Louis, Missouri 63110 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 49, Issue 1, July 1972, Pages 61–80, https://doi.org/10.1093/jnci/49.1.61 Published: 01 July 1972 Article history Received: 19 November 1971 Accepted: 02 March 1972 Published: 01 July 1972
Preliminary Communication
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Joint Study of Extracranial Arterial Occlusion as a Cause of Stroke
Authors: William S. Fields
Journal: JAMA (1968)

Between July 1, 1961, and June 30, 1965, 4,748 patients with signs and symptoms of ischemic cerebrovascular disease were admitted to various institutions for prospective investigation. The mean age for the group was 60 years. Two thirds were below 65 years of age. A significantly larger proportion of nonwhites were in the age group below 55. Eighty-four percent were white, and men outnumbered women 2:1. Interinstitutional differences in clinical status of patients were noted, particularly between vascular surgical and neurologic services. Complete arteriographic studies showing intracranial and extracranial circulation were accomplished in 80%. Twenty-five percent of the patients had no lesions demonstrated or had surgically inaccessible lesions only. The remainder had surgically accessible lesions, both with or without inaccessible lesions. A higher proportion of patients with surgically accessible lesions was noted among whites.
Anhidrotic Ectodermal Dysplasia
Authors: Robert E. Rossman
Journal: JAMA (1966)

CONGENITAL deformities have long challenged the skill of plastic and reconstructive surgeons. The zeal to restore a normal appearance or function should, however, be tempered with an awareness of the possible complications. Patients with anhidrotic ectodermal dysplasia have diminished numbers of skin appendages, including the sweat glands and pilosebaceous structures, that normally contribute cells to reepithelialization processes.<sup>1</sup>Delayed epithelialization of donor sites may occur after skin grafting. The following case report emphasizes this rare but annoying complication. <h3>Report of a Case</h3> A 31-year-old Negro man was admitted to Jefferson Davis Hospital on May 5, 1961, with a left-malar-arch fracture acquired during a fist fight. In addition to the disfigurement and edema associated with this fracture, he had a congenital facial deformity with a flattened nose. The nares pointed anteriorly and no skeletal supporting structures were palpable. An x-ray film of the face confirmed absence of the bony framework of
Methods for early characterisation of the severity and dynamics of SARS-CoV-2 variants: a population-based time series analysis in South Africa
Authors: Emily Reichert, Beau Schaeffer, Shae Gantt, Eva Rumpler, Nevashan Govender, Richard Welch, Andronica Moipone Shonhiwa, Chidozie Declan Iwu, Teresa Mashudu Lamola, Itumeleng Moema-Matiea, Darren Muganhiri, William Hanage, Mauricio Santillana, Waasila Jassat, Cheryl Cohen, David Swerdlow
Journal: The Lancet Microbe (2022)
Tumors Induced in the South American Marmoset Monkey by Rous Sarcoma Virus&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Wilbur Fiske Noyes
Journal: JNCI Journal of the National Cancer Institute (1970)

Metastasizing neoplastic growth was induced in newborn and adult South American marmoset monkeys by the Carr-Zilber and Schmidt-Ruppin strains of the Rous sarcoma virus. Two of eight adult cotton-top marmosets [Saguinus (Oedipomidas) oedipus] inoculated intramuscularly with the Carr-Zilber strain developed slowly growing fibrosarcomas and spindle cell sarcomas. Eleven of twelve adult cottontop marmosets and white-lipped tamarin marmosets (S. nigricollis group) inoculated intramuscularly with the Schmidt-Ruppin strain developed rapidly growing round cell and spindle cell sarcomas, frequently with multinucleated giant cells. These tumors frequently became very large and metastasized regularly to lymph nodes but infrequently to the lungs. Death from Schmidt-Ruppininduced tumor in adults usually occurred in 6–8 weeks. In newborn animals inoculated with this strain, the latent period was as short as 25 days before the development of invasive and metastatic spindle and round cell sarcomas, and terminal stages were reached in 3–6 weeks. Two adult marmosets developed sarcomas after inoculation with a cell-free filtrate of the Schmidt-Ruppin strain. Spontaneous neoplasms were not observed in the marmoset colony over a 4½-vear period.
Animals in research
Authors: A. N Rowan
Journal: Cardiovascular Research (1995)

Animals in research Get access Andrew N Rowan Andrew N Rowan Center for Animals and Public Policy, Tufts University, North Grafton, MA 01536 USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 29, Issue 4, April 1995, Page 583, https://doi.org/10.1016/S0008-6363(96)88538-5 Published: 01 April 1995
Usefulness of pulsed doppler ultrasound in detection of angiographically evident recurrence of hepatocellular carcinoma after arterial embolization treatment
Authors: Satoshi Mochida, Shigeki Hayashi, Itsuro Ogata, Naohiko Masaki, Sumiko Nagoshi, Tomoaki Tomiya, Akihiko Ohno, Katsuyoshi Takatsuki, Yasuhiko Ohta, Shinwa Yamada, Yuzuru Sato, Kuni Ohtomo, Kenji Fujiwara
Journal: Hepatology (1991)

Because hepatocellular carcinoma treated by transcatheter arterial embolization often regains its size, routine follow-up is necessary. The usefulness of pulsed Doppler ultrasound for detection of this type of recurrence was compared with ultrasonography and computed tomography in 21 such hepatocellular carcinomas. Of 15 hepatocellular carcinomas diagnosed by angiography as showing recurrence, four were detected with ultrasonography and five were detected with computed tomography. Doppler signals were obtained in the peripheral portions corresponding to tumor vessels or stains on angiograms in 14 of these 15 hepatocellular carcinomas, but they were undetectable in six hepatocellular carcinomas with no recurrence. All signals disappeared after transcatheter arterial embolization. One false-negative hepatocellular carcinoma with pulsed Doppler ultrasound showed faint tumor stains on angiograms; these were also negative on ultrasonography and computed tomography. Pulsed Doppler ultrasound may be superior to ultrasonography and computed tomography as a routine procedure to detect the recurrence of hepatocellular carcinoma treated by transcatheter arterial embolization. (Hepatology 1991;13:434-437.)
Choice of First-Year Residency Position and Long-term Generalist Career Choices
Authors: Howard K. Rabinowitz
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Domestic violence
Authors: M. S Horner
Journal: BMJ (2002)

# It's not only men who commit domestic violence {#article-title-2} EDITOR—I am disappointed by Jewkes's editorial on domestic violence.1 The clear implication is that men are the oppressors and women suffer. Sadly this is often true, but it is far from being the whole picture. The 1996 British crime survey asked a representative sample of 16 500 adults in England and Wales directly about their experiences of crime, and whether it was reported to the police. The survey included a computer assisted self interviewing questionnaire, designed to give findings on the extent of domestic violence in England and Wales. The results found that 4.2% of women and 4.2% of men said that they had been physically assaulted by a current or former partner in the past year.2 Many studies have found similar results. The work of Straus (a good example of which can be found at http://www.vix.com/menmag/straus21.htm) is particularly authoritative. Indeed, when one considers that most violence against children is committed by women, in terms of gender it is women who are most likely to be perpetrators of domestic violence. Does this manner of presentation matter? I think it does. On a personal level it leads to the situation I encountered recently in my local police station. A man with quite severe injuries after an attack by his former (female) partner was in the cells for breach of the peace. On a broader level it adds to the negative image of men that is so widespread in parts of our popular culture. This does nothing to help the forging of a masculine identity in certain vulnerable young men, which Jewkes says is a risk factor for violence. Why, I wonder, is domestic violence so often portrayed in such a partisan and unscientific way? 1. ↵1. Jewkes R .Preventing domestic violence.BMJ2002; 324:253–254. (2 February.) [OpenUrl][1][FREE Full Text][2] 2. ↵1. Home Office .British crime survey.London:HMSO,1998. # Literature is biased as studies rarely look at female-to-male violence {#article-title-4} EDITOR—Several papers in the BMJ have looked at domestic violence. 1 2 3 Although this … [1]: {openurl}?query=rft.jtitle%253DBMJ%26rft.stitle%253DBMJ%26rft.issn%253D0007-1447%26rft.aulast%253DJewkes%26rft.auinit1%253DR.%26rft.volume%253D324%26rft.issue%253D7332%26rft.spage%253D253%26rft.epage%253D254%26rft.atitle%253DPreventing%2Bdomestic%2Bviolence%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fbmj.324.7332.253%26rft_id%253Dinfo%253Apmid%252F11823345%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=FULL&journalCode=bmj&resid=324/7332/253&atom=%2Fbmj%2F325%2F7354%2F44.atom
Reversible dilated cardiomyopathy following treatment of atopic eczema with Chinese herbal medicine
Authors: J.E. EERGUSON, R.J.G. CHALMERS, D.J. ROWLANDS
Journal: British Journal of Dermatology (1997)

Chinese herbal medicines are increasingly being used as an alternative treatment for chronic skin disease. Most patients and many doctors remain insufficiently aware of their potential toxicity. We report a patient with eczema who developed a severe cardiomyopathy following a 2‐week course of Chinese herbal medicine. The connection between the two conditions was not made until 2 weeks after presentation when the patient was specifically asked if she had ingested any unusual substances. The belief that herbs, as natural products available without prescription, are harmless, is commonplace and patients may not consider them worthy of mention during a standard medical history.
The Protective Effect of Lodoxamide on Antigen-Induced Bronchospasm
Authors: Ronald L. Case
Journal: JAMA (1982)

The inhibition of antigen-induced bronchospasm by lodoxamide ethyl, a new drug with properties similar to those of cromolyn sodium, was studied in 13 asthmatic patients. Single doses were administered orally at weekly intervals in a double-blind randomized fashion 30 minutes before an inhalation challenge of antigen. The drug provided significant protection to immediate antigen-induced bronchospasm compared with placebo as measured by the antigen dose necessary to produce a drop of 20% or greater in the forced expiratory volume in 1 s. (<i>JAMA</i>1982;247:661-664)
Diseases of the Chest and the Principles of Physical Diagnosis.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal