tbuckley/cabot-search huggingface dataset:
Editor's Note: Oncogenic Ras Promotes Reovirus Spread by Suppressing IFNβ Production through Negative Regulation of RIG-I Signaling
Authors: Maya Shmulevitz, Lu-Zhe Pan, Katy Garant, Da Pan, Patrick W.K. Lee
Journal: Cancer Research (2022)

The editors are publishing this note to alert readers to a concern about this article (1).In Fig. 3C, the same image was used to show nontransformed NIH3T3 cells
Selectivity matters: novel ROCK2 inhibitor down-regulates established liver fibrosis via concurrent targeting of inflammatory, fibrotic and metabolic pathways
Authors: Alexandra Zanin-Zhorov, Wei Chen, Melanie Nyuydzefe, Julien Moretti, Iris Zhorov, Rashmi Munshi, Malavika Ghosh, Kelli MacDonald, Bruce Blazar, Sam Waksal
Journal: Journal of Hepatology (2022)
The inhibition of the epigenetic efectors DNMT1 and G9a as a potential therapeutic strategy against the non-alcoholic fatty liver development
Authors: José María Herranz, Alex Claveria-Cabello, Leticia Colyn, Maria U. Latasa, Maite Perez-Araluce, Bruno Sangro, Julen Oyarzabal, Antonio A. Pineda, Maria Arechederra, Carmen Berasain, Matías A. Avila, Maite G. Fernandez-Barrena
Journal: Journal of Hepatology (2022)
Hepatitis B virus splice variants are associated with reduced likelihood of functional cure and differ across phases of chronic hepatitis B infection
Authors: Olivia Maslac, Josef Wagner, Vitina Sozzi, Hugh Mason, Evguenia S Svarovskaia, Susanna Tan, Anuj Gaggar, Stephen Locarnini, Lilly Yuen, Margaret Littlejohn, Peter Revill
Journal: Journal of Hepatology (2022)
Mucosal-associated invariant T cells are rendered functionally exhausted within the tumour microenvironment in HCC in a cell-contact dependent manner
Authors: Junika Pohl, Alexandra Georgieva, Anna-Marie Pedde, Anna Hirschberger, Sebastian Deschler, Melanie Laschinger, Daniel Hartmann, Jan Boettcher, Norbert Hüser, Roland M. Schmid, Percy A. Knolle, Katrin Böttcher
Journal: Journal of Hepatology (2022)
The effect of clinicopathologic findings of hepatocellular carcinoma on posttransplant survival: a multcenter cohort from TASL liver transplantation special interest group
Authors: Murat Akyildiz, Genco Gencdal, Volkan İnce, Muhsin Murat Harputluoglu, Birkan Bozkurt, Murat Zeytunlu, Murat Kılıç, Rasim Farejov, Ilker Turan, Fulya Günsar, Zeki Karasu, Utku Tonguç Yılmaz, Mesut Akarsu, Gökhan Kabaçam, Elvan Onur Kırımker, Ali Atay, Meral Akdogan Kayhan, Hale Gokcan, Gupse Adali, Yaman Tokat, Remzi Emiroğlu, Kamil Yalçin Polat, Sezai Yilmaz, Sedat Karademir, Ramazan Idilman
Journal: Journal of Hepatology (2022)
Secondary sclerosing cholangitis following COVID-19 disease: a multicenter retrospective study
Authors: Peter Hunyady, Lea Streller, Darius Ruether, Sara Reinartz Groba, Dominik Bettinger, Daniel Fitting, Karim Hamesch, Jens Marquardt, Victoria Mücke, Fabian Finkelmeier, Asieb Sekandarzad, Tobias Wengenmayer, Ayoub Bounidane, Felicitas Weiss, Kai-Henrick Peiffer, Bernhard Schlevogt, Stefan Zeuzem, Oliver Waidmann, Marcus Hollenbach, Martha M Kirstein, Johannes Kluwe, Fabian Kütting, Marcus Mücke
Journal: Journal of Hepatology (2022)
Identification of shuttle protein hnRNPA1 as a modulating factor of circulating hepatitis B Virus RNAs release in chronic hepatitis B patients
Authors: Hyoseon Tak, Doohyun Kim, Delphine Bousquet, Marie-Laure Plissonnier, Françoise Berby, Bordes Isabelle, Aaron Hamilton, Marintha Heil, Massimo Levrero, Barbara Testoni, Fabien Zoulim
Journal: Journal of Hepatology (2022)
LINK-B: a hepatitis B program to test and link to care patients lost of follow-up
Authors: Ana Barreira, Ariadna Rando-Segura, Anna Feliu-Prius, Francisco Rodríguez-Frías, Elena Vargas Accarino, Judit Vico-Romero, Mar Riveiro Barciela, Adriana Palom, Rafael Esteban, Maria Buti
Journal: Journal of Hepatology (2022)
Reduced plasma extracellular vesicle CD5L content in patients with acute-on-chronic liver failure: interplay with specialized pro-resolving lipid mediators
Authors: M. Belén Sánchez-Rodríguez, Érica Téllez, Mireia Casulleras, Francesc Borras, Vicente Arroyo, Joan Clària, Maria-Rosa Sarrias
Journal: Journal of Hepatology (2022)
The PNPLA3 I148M variant increases intrahepatic lipolysis and beta oxidation and decreases de novo lipogenesis and hepatic mitochondrial function in humans
Authors: Panu Luukkonen, Kimmo Porthan, Noora Ahlholm, Fredrik Rosqvist, Sylvie Dufour, Xian-Man Zhang, Juhani Dabek, Tiina Lehtimäki, Wenla Seppänen, Marju Orho-Melander, Leanne Hodson, Kitt Falk Petersen, Gerald I. Shulman, Hannele Yki-Järvinen
Journal: Journal of Hepatology (2022)
Viral nucleic acids suppression activity of RO7049389 plus NUC with/without Peg-IFN in virologically-suppressed and naive chronic hepatitis B patients: 48-week treatment and post-treatment follow-up
Authors: Man-Fung Yuen, Rozalina Balabanska, Jinlin Hou, Edward J Gane, Tien Huey Lim, WenHong Zhang, Qing Xie, Piyawat Komolmit, Apinya Leerapun, Sheng-Shun Yang, Chau-Ting Yeh, Wen Zhang, Xue Zhou, Zenghui Xue, Miriam Triyatni, Ethan Chen, Rui Li, Qingyan Bo
Journal: Journal of Hepatology (2022)
Three COVID-19 medications-remdesivir, molnupiravir and ritonavir-boosted nirmatrelvir-and serial liver biochemistries in 22, 456 subjects
Authors: Grace Lai-Hung Wong, Vicki Wing-Ki Hui, Terry Cheuk-Fung Yip, Yee-Kit Tse, Vincent Wai-Sun Wong
Journal: Journal of Hepatology (2022)
Imaging of fibrosis in metabolic associated liver disease by a radiolabeled affibody targeting PDGFRB
Authors: Olivia Wegrzyniak, Johanna Rokka, Bo Zhang, Maria Rosestedt, Bogdan Mitran, Pierre Cheung, Emmi Puuvuori, Sofie Ingvast, Frederik Ponten, Frederik Frejd, Olle Korsgren, Jonas Eriksson, Olof Eriksson
Journal: Journal of Hepatology (2022)
Comparison of CT, blood test, elastometry and their combination for non-invasive staging of liver fibrosis
Authors: Paul Cales, Anita Paisant, Clémence M. Canivet, Jerome Lebigot, Lannes Adrien, Carole Vitellius, Julien Chaigneau, Frédéric Oberti, Isabelle Fouchard, Sophie Michalak, Jerome Boursier, Christophe Aubé
Journal: Journal of Hepatology (2022)
Comprehensive immunophenotyping reveals profound alterations of T cell subsets in acute decompensation of liver cirrhosis
Authors: Yasmina Chouik, Fabienne Venet, Morgane Gossez, Thibault Andrieu, Marie-Laure Plissonnier, Bordes Isabelle, Teresa Antonini, Domitille Erard, Miroslava Subic-Levrero, Francois Villeret, Wafa Khamri, Fabien Zoulim, Massimo Levrero, Fanny Lebossé
Journal: Journal of Hepatology (2022)
Negative impact of COVID-19 infection related to life disruption events and health scores on patients with chronic liver disease
Authors: Zobair Younossi, Yusuf Yılmaz, Mohamed El Kassas, Ajay Kumar Duseja, Saeed Sadiq Hamid, Gamal Esmat, Nahum Méndez-Sánchez, Wah-Kheong Chan, Ashwani Singal, Janus Ong, Brian Lam, Sean Felix, Elena Younossi, Manisha Verma, Jillian Price, Fatema Nader, Issah Younossi, Andrei Racila, Maria Stepanova
Journal: Journal of Hepatology (2022)
Obeticholic acid exacerbates the liver fibrosis of bile duct ligation model by inducing the liver expression of osteopontin
Authors: Jie Wang, Yuan Zihang, Yingying Miao, Haoran Zhang, Qipeng Wu, Xinliang Huang, Luyong Zhang, Q.W Yu, Zhenzhou Jiang
Journal: Journal of Hepatology (2022)
Extracellular concentration of nicotinamid adenine dinucleotide modulates CD203a on TH17 cells and is associated with recurrence of hepatocellular carcinoma
Authors: Felix Krenzien, Julia Babigan, Alexander Arnold, Philipp Brunnbauer, Can Kamali, Karl Hillebrandt, Katrin Splith, Moritz Schmelzle, Johann Pratschke, Christian Benzing
Journal: Journal of Hepatology (2022)
The DNA damage response is involved in the metabolic dysregulation of MAFLD patients via inefficient fatty acid oxidation
Authors: Beatriz Gómez Santos, Idoia Fernámdez-Puertas, Ane Nieva-Zuluaga, Mikel Ruiz de Gauna, Maider Apodaka-Biguri, Francisco González-Romero, Diego Saenz de Urturi, Igotz Delgado, Igor Aurrekoetxea, Lorena Mosteiro González, Gaizka Errazti Olartekoetxea, Sonia Gaztambide, Luis A Castaño González, Luis Bujanda, Jesus Maria Banales, Ana Zubiaga, Xabier Buque, Patricia Aspichueta
Journal: Journal of Hepatology (2022)
Unravelling the role of Protein Kinase D2 in the control of hepatic insulin sensitivity
Authors: Patricia Rada, Ana B. Hitos, Esther Rey, Elena Carceller-Lopez, Julia Pose-Utrilla, Carmelo Garcia-Monzon, Guadalupe Sabio, Teresa Iglesias, Águeda González, Angela Martinez Valverde
Journal: Journal of Hepatology (2022)
Microbial produced ethanol: an underestimated burden on the liver
Authors: Stijn Meijnikman, Mark Davids, Hilde Herrema, Omrum Aydin, Valentina Tremaroli, Joanne Verheij, Maurits De Brauw, Sven Francque, Christophe De Block, Fredrik Backhed, Victor Gerdes, Bert Groen, Max Nieuwdorp
Journal: Journal of Hepatology (2022)
Integrated safety analysis of 24-week data from three phase 2 and one phase 3 clinical trials of bulevirtide monotherapy given at 2 mg and 10 mg dose level for treatment of chronic hepatitis delta
Authors: Pietro Lampertico, Soo Aleman, Tarik Asselah, Marc Bourliere, Adrian Streinu-Cercel, Pavel Bogomolov, Morozov Viacheslav, Tatyana Stepanova, Stefan Lazar, Vithika Suri, Dmitry Manuilov, Lei Ye, John F. Flaherty, Anu Osinusi, Maurizia Brunetto, Heiner Wedemeyer
Journal: Journal of Hepatology (2022)
Formal referral networks optimise patient selection for liver transplantation
Authors: Oliver Tavabie, Victoria Kronsten, Talal Valliani, Deepak Joshi, Johnny Cash, Abid Suddle, Matthew Cramp, Andreas Prachalias, Krishna Menon, Kosh Agarwal, Michael Heneghan, Varuna Aluvihare
Journal: Journal of Hepatology (2022)
Inhibition of hepatitis B surface antigen by RNA interference therapeutic AB-729 is associated with increased cytokine signatures in HBV DNA+ chronic hepatitis B patients
Authors: Sharie C Ganchua, Bhavna Paratala, Christina Iott, Man-Fung Yuen, Edward J Gane, Timothy Eley, Karen Sims, Kevin Gray, Deana Antoniello, Angela M Lam, Michael J. Sofia, Gaston Picchio, Emily P. Thi
Journal: Journal of Hepatology (2022)
Prescription event monitoring of checkpoint inhibitor-induced liver injury and outcomes of rechallenge: a 10-year experience
Authors: Edmond Atallah, Ana Oshaughnessy, Dolapo Igboin, Yvette Moore, Joyce Ntata, Ankit Rao, Hester Franks, Poulam Patel, Guruprasad Aithal
Journal: Journal of Hepatology (2022)
Generation of functional ductal organoid with biliary tree network in decelluarized liver scaffold
Authors: Jiaxian Chen, Xi Liang, Heng Yao, Shiwen Ma, Hui Yang, Deying Chen, Jing Jiang, Dongyan Shi, Jiaojiao Xin, Lei Geng, Yun Li, Jun Li
Journal: Journal of Hepatology (2022)
Urinary proteomics identifies oxidative stress and inflammation pathways as key factors differentiating acute-kidney injury-hepatorenal syndrome from acute tubular necrosis in patients with cirrhosis
Authors: Pere Ginès, Laura Napoleone, Mikel Azkargorta, Jordi Gratacós-Gines, Cristina Solé, Adria Juanola, Ann Ma, Marta Carol, Martina Perez, Ana Belén Rubio, Marta Cervera, Anna Soria, Octavi Bassegoda, Manuel Morales-Ruiz, Núria Fabrellas, Isabel Graupera, Juanjo Lozano, Elisa Pose, Felix Elortza, Elsa Solà
Journal: Journal of Hepatology (2022)
Patients with acute-on-chronic liver failure have significantly greater healthcare resource utilization after liver transplantation
Authors: Vinay Sundaram, Christina Lindenmeyer, Kirti Shetty, Robert Rahimi, Atef Alattar, Gianina Flocco, Brett Fortune, Cynthia Gong, Suryanarayana Challa, Haripriya Maddur, Janice Jou, Michael Kriss, Lance Stein, Ross Vyhmeister, Ellen Green, Braidie Campbell, Josh Levitsky, Constantine Karvellas
Journal: Journal of Hepatology (2022)
HCV reinfection associated with IDU and cocaine use in a cohort of people with OUD: 4 Year follow-up data from the ANCHOR cohort
Authors: Elana Rosenthal, Junfeng Sun, Britt Gayle, Amelia Cover, Ashley Davis, Shivakumar Narayanan, Catherine Gannon, Grace Garrett, Vivian Wang, Meghan Derenoncourt, Henry Masur, Shyamasundaran Kottilil, Sarah Kattakuzhy
Journal: Journal of Hepatology (2022)
Prospective randomized controlled trial of biomarkers for early detection of hepatocellular carcinoma
Authors: Hooman Farhang Zangneh, Orlando Cerocchi, Korosh Khalili, Lima Awad El-Karim, Mara Vecchio, Jeffrey Winick, Yasuhiro Mori, Hiroyuki Yamada, Harry Janssen, Bettina Hansen, Morris Sherman, Jordan Feld
Journal: Journal of Hepatology (2022)
A baseline signature of metabolites involving the gut-liver axis predicts MRI-PDFF response to FASN inhibitor TVB-2640: results from the FASCINATE-1 study
Authors: Rohit Loomba, Marie O’Farrell, Eduardo Martins, Katharine Grimmer, Alithea Zetter, Cristina Alonso, Ibon Martínez-Arranz, George Kemble, Stephen Harrison
Journal: Journal of Hepatology (2022)
P1587: IS IT SAFE FOR OUR PATIENTS TO COME OUT?
Authors: M. Jabbar Al-Obaidi, A. Chew, C. Liu
Journal: HemaSphere (2022)

Background: Vaccination against COVID-19 commenced in England in December 2020, most haematology patients iwere included in the first wave as they are identified as extremely vulnerable. A second dose was administered 12 weeks after the initial dose, and booster doses became available in September 2021. Severely immune compromised patients started to be contacted in December 2021 to offer them a fourth dose of vaccine. With the availability of treatments there arose a need for early confirmation of presence or absence of antibodies against COVID-19 and testing for antibody was introduced into routine practice for patients about to commence chemotherapy, or those who had yet to complete the four-dose protocol. On the 1st of March most restrictions imposed during the pandemic were removed, in the expectation that the majority of people would have protective antibodies from vaccination. Aims: Over a period of six months from October 2021 to February 2022 we tested 90 patients attending routine haematology clinics, with a number of conditions, mainly malignancy under follow-up or recieving treatment. We reviewed the results of these tests, to assess degree of protection Methods: Retrospective analysis of all requests for SARS-Cov antibody tests carried out in our patient populations. Results: There were 55 males, and 35 females, with an average age of 65y (range 24-90) The majority attended clinic for management of haematological malignancy (Plasma cell disorders, Chronic Leukaemia, Lymphomas) with a smaller number of patients being managed for congenital or immune conditions. - Diagnosis No detectable antibody Antibody<500 units Antibody > 500 units Plasma cell disorders 1 5 19 25 tests 22 patients CLL 13 8 5 26 tests in 20 patients HL 1 4 6 11 tests in 10 patients DLBCL 3 1 2 6 MPN 1 5 6 LGNHL 3 5 7 15 tests in 13 patients MCL 2 2 CML 3 3 Immune 2 2 4 Haemoglobinopathy 2 2 CMML 1 1 Total 23 29 49 Summary/Conclusion: Despite early availability of vaccines, and delivery of more than two doses to the majority of our patients, only half our patients had significant antibody response, and almost one quarter still had no detectable antibody. Although the number of new cases is reducing, in the vicinity of our hospital there were 483 new cases per 100,000 on the last day of February, and during the six months of this study two fully vaccinated patients with CLL with no detectctable antibody died in hospital with covid-19 pneumonitis. For some haematology patients particulalry those with CLL it is still not safe to come out.
Highlights from Recent Cancer Literature
Journal: Cancer Research (2022)

The Microenvironment of Tumors and Inflamed TissuesA current limitation of the effectiveness of immunotherapies has toxic effects on the immune system in noncancerous tissues.To identify immune pathways unique to tumors, Mair and colleagues compared immune phenotypes in human head and neck squamous cell carcinomas (HNSCC) with inflamed surrounding oral mucosal tissue and with peripheral blood immune cells, using flow cytometry, single cell transcriptomics, and the NicheNet ligand-receptor analysis tool for cell-cell interactions.First, they found tremendous congruence between immune cells in tumor tissues compared with cells in inflamed nontumor tissues.Second, they discovered that IL1R1 and the previously defined marker ICOS were almost exclusively induced on tumor-infiltrating regulatory T cells (Treg).Third, they found that IL1R1 þ Tregs were highly suppressive.IL1R1 was induced on Tregs acutely, therefore its expression in tumors was likely a consequence of the high activation state of Tregs in tumors.Further, Tregs expressed high levels of the chemokine receptor CXCR6.Its ligand (CXCL16) was highly expressed from monocytes and dendritic cells, specifically in HNSCC.Finally, IL1R1 þ ICOS þ Tregs were enriched in human papillary, breast, and lung cancers, establishing this Treg phenotype across multiple cancer types.
Liver-resident T cell PD-1 correlates with intrahepatic HBV-DNA and is reduced following prolonged antiviral therapy
Authors: Mireia García-López, Laura J. Pallett, Sergio Rodriguez-Tajes, Ernest Belmonte, Thais Leonel, Ester García-Pras, Sabela Lens, Zoe Mariño, Concepció Bartres, Ariadna Rando-Segura, Francisco Rodríguez-Frías, Xavier Forns, Mala Maini, Sofía Pérez-del-Pulgar
Journal: Journal of Hepatology (2022)
Rationale for evaluation of PLN-74809 treatment in participants with primary sclerosing cholangitis in Phase 2a study INTEGRIS-PSC
Authors: Eric Lefebvre, Greg Cosgrove, Simon Wong, Erica Park, Fiona Cilli, Theresa Thuener, Marzena Jurek, Scott Turner, Martin Decaris, Johanna Schaub
Journal: Journal of Hepatology (2022)
Sofosbuvir plus velpatisvir for 8 weeks in patients with acute hepatitis C: multicenter, single arm, phase 2 study (The HepNet acute HCV-V study)
Authors: Benjamin Maasoumy, Patrick Ingiliz, Christoph Spinner, Christiane Cordes, Hans-Jürgen Stellbrink, Julian Schulze zur Wiesch, Stephan M Schneeweiß, Katja Deterding, Tobias Müller, Julia Kahlhöfer, Petra Dörge, Maria von Karpowitz, Michael P. Manns, Heiner Wedemeyer, Markus Cornberg
Journal: Journal of Hepatology (2022)
Quantitative assessment of liver fibrosis in NASH patients
Authors: Luong Ruiz, Tian Lan, Wenhui Liu, Amir Ashique, Harry Chen, Jiping Zha, Alex DePaoli, Igor Mikaelian, Cynthia Guy, Eugenia Henry, William Chang, Corinne Foo-Atkins, Hsiao Lieu
Journal: Journal of Hepatology (2022)
Human antigen R (HuR) is a master regulator of hepatic glucose metabolism
Authors: Sofia Lachiondo-Ortega, Miren Bravo, Irene González-Recio, María J. González Rellán, Jorge Simón Espinosa, Naroa Goikoetxea, Petar Petrov, Rubén Rodríguez Agudo, Arantza Sanz-Parra, Begoña Rodriguez Iruretagoyena, Teresa Cardoso Delgado, Dan A. Dixon, Myriam Gorospe, Ruben Nogueiras, María Luz Martínez-Chantar
Journal: Journal of Hepatology (2022)
Stratified efficacy of first -line therapy to prevent first variceal bleeding according to previous decompensation of cirrhosis. A competing-risk meta-analyses of individual participant data
Authors: Càndid Villanueva, Víctor Sapena, Gin-Ho Lo, Yeon Seok Seo, Hasnain A. Shah, Virendra Singh, Dhiraj Tripathi, Michael Schepke, Cristian Gheorghe, Danielle Q Bonilha, Rome Jutabha, Susana G. Rodrigues, Edilmar Alvarado-Tapias, Anna Brujats, Peter Hayes, Tilman Sauerbruch, Wen-Chi Chen, Speranta Iacob, Ermelindo D Libera, Dennis M Jensen, Pramod Kumar, Lee Han Ah, Huay-Min Wang, Ferran Torres, Zahid Azam, Jaime Bosch
Journal: Journal of Hepatology (2022)
Assessment of COVID-19 impact and response on hepatitis B virus and hepatitis C virus prevention and treatment from nationwide survey in Japan
Authors: Md Razeen Ashraf Hussain, Aya Sugiyama, Lindsey Hiebert, Serge Ouoba, Bunthen E, Ko Ko, Tomoyuki Akita, Shuichi Kaneko, Tatsuya Kanto, John Ward, Junko Tanaka
Journal: Journal of Hepatology (2022)
Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity
Authors: Valerio Azzimato, Ping Chen, Emelie Barreby, Cecilia Morgantini, Laura Levi, Ana Vankova, Jennifer Jager, André Sulen, Marina Diotallevi, Joanne X. Shen, Ewa Ellis, Mikael Ryden, Erik Naslund, Anders Thorell, Volker Lauschke, Keith M. Channon, Mark J. Crabtree, Arvand Haschemi, Siobhan M. Craige, Mattia Mori, Francesco Spallotta, Myriam Aouadi
Journal: Journal of Hepatology (2022)
Factors associated with HCC stage at presentation and survival in an ethnically diverse UK population
Authors: Jessica Spiers, Wenhao Li, Aloysious Aravinthan, Katharine Caddick, Yaqza Hussain, Ayman Bannaga, Saad Muhammad, Muhammad Nauman Tahir, Abhishek Sheth, Ankur Srivastava, Mohsan Subhani, Esther Unitt, Nwe Ni Than, William Alazawi
Journal: Journal of Hepatology (2022)
Application of machine learning algorithms to classify steatohepatitis on liver biopsy
Authors: Resham Ramkissoon, Joseph Ahn, Yung-Kyun Noh, Yubin Yeon, Chady Meroueh, Priya Thanneeru, Amit Das, Jason Hipp, Alina Allen, Douglas Simonetto, Patrick S. Kamath, Vijay Shah
Journal: Journal of Hepatology (2022)
Renal and circulatory effects of terlipressin in patients with hepatorenal syndrome assessed by magnetic resonance imaging
Authors: Karen Vagner Danielsen, Jens Hove, Puria Nabilou, Thit Kronborg, Signe Wiese, Hartwig R. Siebner, Søren Møller, Flemming Bendtsen
Journal: Journal of Hepatology (2022)
In vitro rescue of nonsense variations by drug-induced readthrough of premature termination codons in progressive familial intrahepatic cholestasis type 2
Authors: Martine Lapalus, Elodie Mareux, Rachida Amzal, Marion Almes, Alice Thebaut, Mounia Lakli, Thomas Falguières, Sylvie Rebuffat, Laure Bidou, Olivier Namy, Emmanuel Jacquemin, Emmanuel Gonzalès
Journal: Journal of Hepatology (2022)
Characterization of energy and substrate metabolism in patients with spontaneously breathing and mechanically ventilated patients with liver cirrhosis: an indirect calorimeter based study
Authors: Varsha Shasthry, Jaya Benjamin, Rakhi Maiwall, Vandana Saluja, Prashant Mohan Agarwal, Guresh Kumar, Yogendrakumar Joshi, Shiv Kumar Sarin
Journal: Journal of Hepatology (2022)
Improved recurrence-free survival rates in patients with HCV-related hepatocellular carcinoma and sustained virological response to direct-acting antivirals
Authors: Cristina-Maria Muzica, Anca Trifan, Laura Huiban, Oana Stoica, Irina Girleanu, Stefan Chiriac, Ana-Maria Singeap, Camelia Cojocariu, Tudor Cuciureanu, Sebastian Zenovia, Robert Nastasa, Carol Stanciu
Journal: Journal of Hepatology (2022)
DNA methylation regulates lncRNAs compromising hepatic identity during hepatocarcinogenesis
Authors: Miriam Recalde, María Gárate-Rascón, José María Herranz, María Elizalde, María Azkona, Juan Pablo Unfried, Bruno Sangro, Maite G Fernandez-Barrena, Puri Fortes, Matías A Avila, Carmen Berasain, Maria Arechederra
Journal: Journal of Hepatology (2022)
Personalized preemptive TIPS treatment for patients with Child-Pugh B cirrhosis and acute variceal bleeding by applying individualized of prediction of treatment effect
Authors: Yong Lv, Wei Bai, Kai Li, Dongdong Xia, Zhengyu Wang, Bohan Luo, Xiaomei Li, Jie Yuan, Zhanxin Yin, Daiming Fan, Guohong Han
Journal: Journal of Hepatology (2022)
Sustained low prevalence of HCV viremia among people who inject drugs following the treatment as prevention for hepatitis C (TraP HepC) nationwide elimination program in Iceland
Authors: Magnús Gottfredsson, Valgerdur Runarsdottir, Thorvardur J. Löve, Ragnheidur H. Fridriksdottir, Thorarinn Tyrfingsson, Ingunn Hansdottir, Ottar M. Bergmann, Einar S. Björnsson, Birgir Johannsson, Bryndis Sigurdardottir, Arthur Löve, Guðrún Erna Baldvinsdóttir, Marianna Thordardottir, Ubaldo Benitez Hernandez, Maria Heimisdottir, Sigurdur Olafsson
Journal: Journal of Hepatology (2022)
Discovery of AMS-III-1086, a novel LPA1 antagonist for the treatment of liver fibrosis and liver cirrhosis
Authors: Nakcheol Jeong, Peppi Prasit, Jung-Hee Kim, Misun Lee, Bo-Yeong Pak, Sojin Ahn, Gil Won Lee, Seohyun Min, Sanghyeok Lee, Yeup Yoon, Wonseok Kang, Hyeree Kim
Journal: Journal of Hepatology (2022)
miRNA associated with systemic inflammation may have prognostic utility in predicting decompensation in patients with chronic liver disease
Authors: Oliver Tavabie, Vishal C Patel, Siamak Salehi, Marilena Stamouli, Francesca Trovato, Savannah Rivera, Salma Mujib, Ane Zamalloa, Eleanor Corcoran, Krishna Menon, Andreas Prachalias, Michael Heneghan, Kosh Agarwal, Mark J W McPhail, Varuna Aluvihare
Journal: Journal of Hepatology (2022)