AB1555 CORRELATION BETWEEN HIGH RESOLUTION CHEST TOMOGRAPHY AND CAPILLAROSCOPIC FINDINGS IN SYSTEMIC SCLEROSIS
Authors: J. Santana Peralta, R. A. Alvarez Santana, D. Garcia, L. Perez, T. Polanco Mora, L. Concepción Sanchez, I. Paulino, I. Mercedes, E. Rodriguez Bautista, T. Valdez, A. Feriz, R. Muñoz Louis
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Systemic sclerosis (SSc) is a chronic autoimmune multisystemic disease characterized by fibrosis and vasculopathy.<sup>[1]</sup> Mortality in patients with systemic sclerosis who present with interstitial lung disease can be up to 3x healthy population.<sup>[2]</sup> It is estimated that 70-90% have interstitial lung disease.<sup>[3]</sup> High resolution computed tomography (HRCT) of chest is recognized as a sensitive imaging method for evaluating pulmonary involvement.<sup>[4,5]</sup> Presentation patterns are also described: NSIP (non specific interstitial pneumonia), UIP (usual interstitial pneumonia), COP (cryptogenic organizing pneumonia), LIP (Lymphocytic interstitial pneumonitis). Capillaroscopy allows the study of the microcirculation. Changes are classified into "early," "active," and "late" scleroderma patterns.<sup>[6]</sup> <h3>Objectives</h3> To relate between high resolution chest tomography and capillaroscopic findings in Systemic sclerosis. <h3>Methods</h3> Descriptive, observational, cross-sectional study. Capillaroscopy with Optilia CapiScope 2.0/5.0MP and lung ultrasound with Siemmens Acuson X150 were performed in patients with SSc in the outpatient clinic of the rheumatology service from August-November 2021. Inclusion criteria: &gt; 18 years old, meet criteria for classification of SSc according to ACR/EULAR 2013. Exclusion criteria: history of pre-existing lung disease. <h3>Results</h3> 22 patients met inclusion criteria. 80% were female. Diffuse SSc 81.8% (18), limited SSc 18.2% (4). Mean age 54±17 years, disease duration 58.1% (13) &gt;5 years and 40.9% (9) &lt; 5 years, mean diagnosis 15.3±9.2 years, mean mRSS 19.4 + 13.2 mRSS Mild: 22.7% (5), moderate 18.2% (4), severe 27.3% (6), terminal 31.8% (7). ANA+ 45.5% (10), Topo IA 18.2% (4). Treatment: RTX 77.3% (17), Ca+ antagonists 68.2% (15), Bosentan 36.4% (8), MMF 36.4% (8), Colchicine 31.8% (7), Sildenafil 27.3% (6). Capillaroscopy: normal pattern 59% (13), early scleroderma pattern 9.1% (2), active scleroderma pattern 4.5% (1), late scleroderma pattern 22.7% (5), nonspecific abnormalities 4.5% (1). TACAR: 54.5% (12) normal, pathological findings 45.4% (10): NSIP pattern 80% (8), UIP 20% (2). TACAR/Capillaroscopy correlation: UIP pattern and early scleroderma pattern 4.5% (1) rp=.112, NSIP pattern and active scleroderma pattern 4.5% (1) rp=.769, NSIP pattern and normal capillaroscopy 4.5% (1) rp=. 518, NSIP pattern and late scleroderma pattern 27.2% (6) rp=1, normal TACAR and capillaroscopy with nonspecific abnormalities 4.5% (1) rp=1, UIP pattern and early pattern 4.5% (1) rp=.622, normal TACAR and normal capillaroscopy 27.2% (6). <h3>Conclusion</h3> We found in this study that capillaroscopic findings of active and late patterns correlated with greater pulmonary involvement. It is recommended to follow patients with early patterns and the existence or not of interstitial pattern and to evaluate response to medication. <h3>References</h3> [1]Morrisroe K, Stevens W, Sahhar J. The clinical and economic burden of systemic sclerosis related interstitial lung disease. Rheumatology. 2019;0(1):1-11. [2]Volkmann E, Tashkin D, Sim M, Kim G, Goldin J, Clements P. Determining progression of scleroderma-related interstitial lung disease. Journal of Scleroderma and Related Disorders. 2018;4(1):62-70. [3]Simeón-Aznar C, Fonollosa-Plá V, et al. Registry of the Spanish Network forSystemic Sclerosis. Medicine. 2015;94(43):e1728. [4]Hussein, K., Shaaban, L. and Mohamed, E., 2016. Correlation of high resolution CT patterns with pulmonary function tests in patients with interstitial lung diseases. Egyptian Journal of Chest Diseases and Tuberculosis, 65(3), pp.681- 688. [5]Chung JH, Walker CM, Hobbs S. Imaging Features of Systemic Sclerosis- Associated Interstitial Lung Disease. J Vis Exp. 2020 [6]Man, M., Dantes, E., Domokos Hancu, B., Bondor, C., Ruscovan, A., Parau, A., Motoc, N. and Marc, M., 2019. Correlation between Transthoracic Lung Ultrasound Score and HRCT Features in Patients with Interstitial Lung Diseases. Journal of Clinical Medicine, 8(8), p.1199. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.