15-Year Benefits of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality
Authors: Frederik E. Juul, Amanda J. Cross, Paul Pinsky, Carlo Senore, Magnus Løberg
Journal: Annals of Internal Medicine (2023)

LettersJune 202315-Year Benefits of Sigmoidoscopy Screening on Colorectal Cancer Incidence and MortalityFrederik E. Juul, MD, Amanda J. Cross, PhD, Paul Pinsky, PhD, Carlo Senore, MD, MSc, Magnus Løberg, MD, PhDFrederik E. Juul, MDClinical Effectiveness Research Group, Department of Transplantation Medicine, Oslo University Hospital, and Clinical Effectiveness Research Group, University of Oslo, Oslo, NorwaySearch for more papers by this author, Amanda J. Cross, PhDCancer Screening and Prevention Research Group, Department of Surgery and Cancer, Imperial College London, London, United KingdomSearch for more papers by this author, Paul Pinsky, PhDNational Cancer Institute, Division of Cancer Prevention, Rockville, MarylandSearch for more papers by this author, Carlo Senore, MD, MScUniversity Hospital Città della Salute e della Scienza, Turin, ItalySearch for more papers by this author, Magnus Løberg, MD, PhDClinical Effectiveness Research Group, Department of Transplantation Medicine, Oslo University Hospital, and Clinical Effectiveness Research Group, University of Oslo, Oslo, NorwaySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L23-0025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE: Dr. Brenner and colleagues contend that our study fails to adequately characterize the preventive effect of flexible sigmoidoscopy screening on CRC incidence because it included cases of prevalent cancer detected in the initial phase of screening. The goal of our research was to estimate the real-world effectiveness of offering sigmoidoscopy screening on the risk for developing and dying of CRC. We believe the best way to do this is with intention-to-screen analyses that include all individuals and all detected CRC cases and deaths from inclusion in the trial until the end of follow-up.Endoscopic screening for CRC reduces ...References1. Doroudi M, Schoen RE, Pinsky PF. Early detection versus primary prevention in the PLCO flexible sigmoidoscopy screening trial: which has the greatest impact on mortality. Cancer. 2017;123:4815-4822. [PMID: 28976536] doi:10.1002/cncr.31034 CrossrefMedlineGoogle Scholar2. Segnan N, Armaroli P. Early detection versus prevention in colorectal cancer screening: methods estimates and public health implications [Editorial]. Cancer. 2017;123:4767-4769. [PMID: 28976554] doi:10.1002/cncr.31032 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Frederik E. Juul, MD; Amanda J. Cross, PhD; Paul Pinsky, PhD; Carlo Senore, MD, MSc; Magnus Løberg, MD, PhDAffiliations: Clinical Effectiveness Research Group, Department of Transplantation Medicine, Oslo University Hospital, and Clinical Effectiveness Research Group, University of Oslo, Oslo, NorwayCancer Screening and Prevention Research Group, Department of Surgery and Cancer, Imperial College London, London, United KingdomNational Cancer Institute, Division of Cancer Prevention, Rockville, MarylandUniversity Hospital Città della Salute e della Scienza, Turin, ItalyDisclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M22-0835. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee Also15-Year Benefits of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality Frederik E. Juul , Amanda J. Cross , Robert E. Schoen , Carlo Senore , Paul Pinsky , Eric Miller , Nereo Segnan , Kate Wooldrage , Paulina Wieszczy-Szczepanik , Paola Armaroli , Kjetil K. Garborg , Hans-Olov Adami , Geir Hoff , Mette Kalager , Michael Bretthauer , Magnus Løberg , and Øyvind Holme 15-Year Benefits of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality Hermann Brenner , Thomas Heisser , Rafael Cardoso , Michael Hoffmeister Metrics Current IssueJune 2023Volume 176, Issue 6KeywordsCancer screeningColorectal cancerFlexible sigmoidoscopy ePublished: 20 June 2023 Issue Published: June 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...