tbuckley/cabot-search huggingface dataset:
New Commission for Study of Accreditation of Selected Health Education Programs
Authors: J. F. Volker
Journal: JAMA (1971)

During the 1960s there were many evidences of an increasing interest in education programs and service roles of allied health personnel. The Allied Health Professions Personnel Training Act of 1966, the report of the Allied Health Professions Education subcommittee of the National Advisory Health Council in 1967, the formation of the Association of Schools of Allied Health Professions, and the<i>Report of the National Advisory Commission on Health Manpower</i>are expressions of the concern.<sup>1,2</sup> There is every indication of immediate and continuing need for allied health manpower. A recent publication of the US Department of Health, Education, and Welfare projects that the numbers of physicians will expand from 305,500 in 1967 to 407,300 in 1980. During the same period, the number of allied health workers with at least a baccalaureate degree will increase from 175,000 to 320,000, and those with less than a bacallaureate degree will expand from 276,500
Rapid intravenous administration of corticotropin as a test of adrenocortical insufficiency
Authors: B. U. Musa
Journal: JAMA (1967)

The one-hour response of plasma-fluorescent corticoid concentrations to 25 units of corticotropin has allowed complete separation of a group of seven patients with adrenal insufficiency from another group of 31 patients with findings suggestive of adrenal insufficiency but having, in fact, normal adrenal function. From the standpoint of time required for the analytical procedure, availability of reagents, and apparatus requiring no modification, the laboratory techniques described are suitable for a small clinical laboratory.
Kurzes Handbuch der Ophthalmologie.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
American Medical Association Auxiliary, Inc 1987 Annual Convention June 21 Through 24,1987 The Drake, Chicago
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Methylsulfonyl metabolites of PCBs and DDE in human milk in Sweden, 1972-1992
Authors: K Norén, A Lundén, E Pettersson, A Bergman
Journal: Environmental Health Perspectives (1996)

A multicomponent method used for analysis o°b iphenyls (PCBs), napht , dib analysis.of y nIo of d (M `O2-DDE in human Mlk T t partitining.Adtonal p-O and permeation chromography.Te mean reoeri dards, added to the milk before aion, were dur 1972
Public Information...
Authors: Phil Gunby
Journal: JAMA (1987)

PUBLIC INTEREST in medical science and its clinical applications seems to increase yearly, as—apparently— does discussion of the physician's role in informing the laity as a group. Nearly a century ago,The Journalopined editorially: "The physician, whatever he may say or not say [to the public through the news media] in attendance upon a public officer of high rank, is almost certain to be misunderstood. The wiser course then is to keep silence..." (<i>JAMA</i>1893;21:133). That, of course, is no longer possible, as the recalling of the 1981 wounding of President Reagan and other reports in this MEDICAL NEWS &amp; PERSPECTIVES section make clear. Thus, what physicians are doing today to communicate effectively with the public at large is a fascinating story in itself—a story that this section of Contempo 1987 undertakes, at least in Dart, to tell. —by
Abstract 4603: To analyse PIMT function in glioblastoma cell invasion
Authors: Fatima Belkourchia, Richard Desrosiers
Journal: Cancer Research (2019)

Abstract The protein L-isoaspartyl (D-aspartyl) methyltransferase (PIMT) is an enzyme able to repair abnormal L-aspartyl residues in damaged proteins. Among examined tissues, PIMT shows the highest level in brain. U87-MG cells are a commonly used grade IV cellular model to study the most frequent brain tumor, the glioblastoma. Previously, we reported that PIMT amount increased when U87-MG cells were detached from the extracellular matrix. Recently, our laboratory also showed that PIMT possessed pro-angiogenic properties. Together, these PIMT features led us to postulate that PIMT could play a critical role in glioblastoma growth. To investigate PIMT involvement during glioblastoma growth, we analyzed its role in U87-MG cell viability, adhesion, migration, invasion, clonogenic properties and the reorganization of the actin cytoskeleton. For instance, PIMT inhibition by siRNA reduced cell migration and invasion by different assays: in wound healing assay, in Boyden chambers coated with gelatin and in Matrigel invasion assay. Conversely, in stably transfected U87-MG cells overexpressing wild-type PIMT, cell migration, invasive capacity and colony formation significantly increased. However, in stably transfected cells with the gene encoding for the inactive PIMT D83V, in spite of its overexpression, the migration and invasion remained similar to that observed in control cells transfected with the empty plasmid. In all these conditions, cell viability was unaffected. Finally, the reorganization of the actin cytoskeleton is regulated by PIMT protein level. Overall, these data enlighten the importance of PIMT level and mainly of its catalytic activity in migration and invasion of malignant glioma U87-MG cells and its possible contribution in cancer cell invasion during glioblastoma growth. Citation Format: Fatima Belkourchia, Richard Desrosiers. To analyse PIMT function in glioblastoma cell invasion [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4603.
Polybrominated Biphenyl (PBB) in the Growing Pig Diet
Authors: P. K. Ku, M. G. Hogberg, A. L. Trapp, P. S. Brady, E. R. Miller
Journal: Environmental Health Perspectives (1978)

Twelve pigs which averaged 13.7 kg were randomly allotted from litters to a corn-soybean meal grower diet containing 0, 20, or 200 ppm of polybrominated biphenyls (PPB). During a 16-week growth trial, average daily gain (kg), average daily feed (kg) and feed/gain for pigs on diets containing 0, 20, or 200 ppm of PBB, respectively, were 0.82, 2.45, 2.99; 0.67, 1.88, 2.79; 0.45, 1.23, 2.70. Mean daily gain differences between all lots were highly significant (p &lt; 0.01). Blood from each pig was withdrawn biweekly through the first 8 weeks of the trial and at 4 week intervals thereafter. Hemoglobin and hematocrit differed significantly only at the 6 weeks bleeding, being reduced in pigs receiving 200 ppm of PBB. Erythrocyte reduced glutathione concentration and glutathione peroxidase activity were not significantly influenced by level of dietary PBB. Serum lactic dehydrogenase activity was significantly higher in control pigs than in either PBB supplemented lots at 16 weeks. There was no significant influence of PBB upon serum glutamic oxaloacetic transaminase, serum alkaline phosphatase or serum creatine phosphokinase. Based on these enzyme assays, PBB produced no evidence of significant necrosis of liver, myocardium, or skeletal muscle. There was no consistent effect of dietary PBB upon total serum protein concentration or electrophoretic profile. Pigs on either level of PBB did not have overt clinical signs of toxicity during the 16-week test period with the exception of a dermatosis on the ventral surface of two of the pigs receiving 200 ppm of PBB. There was a marked increase in liver weight of pigs receiving either level of dietary PBB. Heart, kidney, and adrenals of pigs receiving either level of dietary PBB were heavier as a percent of body weight than that of control pigs. Fat retention of PBB and urinary and fecal PBB excretion were significantly affected by dietary PBB level. Grossly, the glandular portion of the stomach appeared somewhat hyperplastic in pigs on 200 ppm of PBB. Two pigs which had received 200 ppm of PBB were placed on the control diet and over the next 14 weeks normal growth rate occurred. One of these pigs was killed and organ weights were normal. The other pig, a gilt, came into estrus. She was bred and conceived. At the end of gestation, four pigs were born. Three survived and grew normally; the one death at birth examined at gross necropsy did not reveal changes in organ size or other tissue alterations.
Abstract 31: Acute Febrile Acrodynia (1781-1966): Historical Cases Of Kawasaki Disease Before Kawasaki?
Authors: Deniz Yeter, Ho-Chang Kuo
Journal: Circulation (2015)

Infantile acrodynia is a mercurial reaction that can mimic the complete clinical picture of Kawasaki disease (KD), and is therefore considered a differential diagnosis for KD. Before the 1950s, acrodynia affected 1 in 500 children in industrialized nations. The recently formed pediatric community was fascinated by this new disease since the late 1800s, resulting from the child’s extreme irritability along with striking mucocutaneous changes such as the bright red, swollen hands and feet. Parents would initially report their child suffered from a sudden fever caused by an undetermined infection. Children were not typically seen in hospital until their case became protracted and the insidious symptoms of advanced acrodynia were apparent weeks later. In the 1950s, it was discovered that mercurial remedies such as teething powders were a cause of acrodynia, leading to their removal from the market. Physicians in the British Isles first reported acrodynia in the medical literature after the use of mercurials were extended from adult syphilitic patients to the generalized patient population in the late 1700s. Previously, these acute febrile mercurial reactions were mistaken as a form of secondary syphilis. During the early to mid-1900s, it was noted that syphilitic patients undergoing mercurial or arsenical treatment were more likely to develop arterial thromboses, particularly of the coronary arteries, leading to diagnoses of a unique polyarteritis nodosa. Sudden death in infantile acrodynia often results from secondary infections, arterial thromboses, and cardiac failure. Shortly after acrodynia became a rare pediatric ailment, KD was first observed by Kawasaki in 1961 and reported in 1967. This coincides with unprecedented increases of mercury pollution and seafood contamination in East Asia, resulting in Minamata disease outbreaks during the 1950s and 1960s in Japan. Outbreaks of Minamata disease have been observed among indigenous populations in Canada since the 1970s, while Canada has the highest rates of KD outside of East Asia or Hawaii. Temporal associations are seen with increases and reductions of thimerosal from routine pediatric vaccines and KD outbreaks in the US and Japan. KD may in part represent a modern re-emergence of infantile acrodynia.
Antibody and T-cell receptors
Authors: S. Tonegawa
Journal: JAMA (1988)

A VERTEBRATE is an attractive culture medium for viruses, bacteria, fungi, and metazoan parasites. It is therefore understandable that vertebrates have had to develop a body defense mechanism directed toward these pathogens for their emergence and survival. This defense mechanism is the See also pp 1834 and 1837. immune system. The crucial event in mounting an immune response is the recognition of chemical markers that are present on infectious organisms and foreign bodies. The molecules entrusted to this task are the B-cell-synthesized antibodies and the antigen-specific T-cell receptors (TCRs). Antigens are numerous and structurally diverse. The fact that the body can produce antibodies against many artificially made chemicals and can discriminate among them attests to the vastness of the antigenic world. The antigen-binding specificity of an antibody or a TCR is determined by the amino acid sequence of the polypeptide chains that compose these proteins. The enormous diversity of antigens,
Abstract O.10: Risk Factors Associated with Recurrence of Kawasaki Disease in Mexican Children
Authors: Giovanni Sorcia-Ramirez, Luis M Garrido-Garcia
Journal: Circulation (2015)

Background: Kawasaki disease (KD) is an acute febrile illness characterized by systemic vasculitis. Recurrences of KD (defined as at least three clinical signs of KD in addition to fever ≥ 5 days), presenting ≥ 14 days after the return to baseline from the index episode is reported in approximately 3-4% of all cases in Japan. Objective: To assess the frequency and determined the risk factors associated with recurrences of KD in patients treated at the Instituto Nacional de Pediatría in Mexico City. Material and Methods: An observational, comparative, retrospective and case-control study of all patients diagnosed with recurrent KD in our Institution from August 1995 and May 2014 was performed. The clinical presentation, laboratory results, treatment used and coronary artery abnormalities in the recurrent-KD and non-recurrent KD groups were analyzed and compared. Results: We included 371 patients with KD diagnosed at our institution; we had 19 recurrences of KD (5.1%), 16 patients had one recurrence, 1 patient had 2 recurrences and 1 patient had 3 recurrences of KD. 17 cases or our cases were male (89.4%) with mean age at diagnosis of the first episode of 31.63 ± 36.40 months and with a median of 16 months of the new event after the initial episode (1 to 60 mo.) In bivariate analysis, male gender (p &lt; 0.037), central nervous system manifestations in the acute phase of KD (p &lt; 0.053) and coronary aneurysms at diagnosis (p &lt; 0.05) showed statistical significance. There were no factors associated with recurrence in a multivariate analysis. Conclusions: This is a very small series of KD with a slightly increased rate of recurrence compared with the rate of recurrences reported in the literature. But to allow an early recognition of a new event, a previous history of KD should be considered to initiate treatment and to achieve better outcomes in the recurrent cases.
Researchers' Goals: To Enhance, Suppress Immunologic Response
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bilirubin production and excretion. Clinical considerations
Authors: M. Menken
Journal: JAMA (1966)

The serum bilirubin level represents an equilibrium achieved by a dynamic process of production and excretion. A hyperbilirubinemia that remains constant over a period of time represents an equilibrium at a higher serum level than normal, due either to overproduction of bilirubin from one or more sources with a normal excretion rate, or a decreased rate of excretion with a normal production rate. A rising or falling serum bilirubin, on the other hand, represents an imbalance of production and excretion. A number of the steps in bile pigment production and excretion have now been elucidated. However, in patients with an elevated serum bilirubin concentration the diagnosis is often based on a search for specific ancillary features rather than an understanding of the pathophysiological mechanism involved. Most laboratories, for example, continue to report the plasma bilirubin concentration as the "one-minute" (or "direct-reacting") bilirubin and the "total" bilirubin concentration, even though the
GERONTOLOGY
Authors: E. J. S.
Journal: Annals of Internal Medicine (1940)

Editorial1 October 1940GERONTOLOGYE. J. S.E. J. S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-4-737 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGerontology, which is the science of aging, is no longer of mere academic interest, but presents innumerable significant questions urgently demanding study and solution. Aging is a continuous biologic process which commences immediately upon the creation of a new individual and continues until death. Therefore, gerontology crosses the pathways of thought of all biologic sciences and presents problems at all ages. In this, gerontology differs conspicuously from geriatrics which has been defined as "that branch of medical science which treats of theagedin their physiologic and pathologic relations." Thus geriatrics is concerned with the consequences of senescence, the end...1 DUBLIN LI: Chapter 6 in COWDRY'S "Problems of aging," 1939, Williams & Wilkins Co., Baltimore. Google Scholar2 CARREL A: Physiological time, Science, 1931, lxxiv, 618. DUNOÜY, PIERRE: Biological time, 1937, Macmillan, N. Y. CrossrefGoogle Scholar3 WARTHIN AS: Old age: The major involution, 1929, Paul B. Hoeber, Inc., N. Y. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1940Volume 14, Issue 4Page: 737-740KeywordsAgingBiologicsGeriatrics ePublished: 1 December 2008 Issue Published: 1 October 1940 PDF downloadLoading ...
THE INCREASING PNEUMONIA MORTALITY.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contents
Authors: Mengyu Wang, Lucy Shen, Louis Pasquale, Michael Boland, Sarah Wellik, Carlos De Moraes, Jonathan Myers, Thao Nguyen, Robert Ritch, Pradeep Ramulu, Hui Wang, Jorryt Tichelaar, Dian Li, Peter Bex, Tobias Elze, Alessandro Rabiolo, Esteban Morales, Ji Kim, Abdelmonem Afifi, Fei Yu, Kouros Nouri-Mahdavi, Joseph Caprioli, Anthony Khawaja, Joanna Campbell, Nicholas Kirby, Hitesh Chandwani, Ian Keyzor, Mousam Parekh, Andrew Mcnaught, Owen Siggs, Emmanuelle Souzeau, Deepa Taranath, Andrew Dubowsky, Angela Chappell, Tiger Zhou, Shari Javadiyan, Jillian Nicholl, Lisa Kearns, Sandra Ophthalsci, Andrew Staffieri, James Narita, John Pater, Alex Hewitt, Jonathan Ruddle, James Elder, David Mackey, Kathryn Burdon, Jamie Craig, Janey Wiggs, Nancy Holekamp, Charles Wykoff, Steffen Schmitz-Valckenberg, Jordi Monés, Eric Souied, Hugh Lin, Melvin Rabena, Ronald Cantrell, Erin Henry, Fan Tang, Balakumar Swaminathan, Jillian Martin, Daniela Ferrara, Giovanni Staurenghi, Panos Christakis, Elvira Agrón, Michael Klein, Traci Clemons, J Campbell, Frederick Ferris, Emily Chew, Tiarnan Keenan, B Bch, Jessica Loo, Martin Friedlander, Glenn Jaffe, Sina Farsiu, Theodore Leng
Journal: Ophthalmology (2020)
Landry-Guillain-Barré Syndrome: Report of an Unusual Case with Comment on Bell's Palsy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal