tbuckley/cabot-search huggingface dataset:
A commentary on ‘Laparoscopic versus open repeat hepatectomy for recurrent hepatocellular carcinoma: a systematic review and meta-analysis of propensity score-matched cohort studies’
Authors: Furui Zhong, Chuanbo Xie, Xuefeng Peng, Hua Yang
Journal: International Journal of Surgery (2023)

aDepartment of General Surgery of Huidong, Zigong Fourth People's Hospital, Zigong, 643000, Sichuan Province, China bDepartment of Ultrasound, Zigong Hospital of Woman and Children Healthcare, Zigong, 643000, Sichuan Province, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of General Surgery of Huidong, Zigong Fourth People's Hospital, No. 282, Dangui Street, Ziliujing District, Zigong, 643000, Sichuan Province, China. Tel: +86 15884169385. E-mail address: [email protected] (H. Yang). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML
Authors: Christopher T. Letson, Maria E. Balasis, Hannah Newman, Moritz Binder, Alexis Vedder, Fumi Kinose, Markus Ball, Traci Kruer, Ariel Quintana, Terra L. Lasho, Christy M. Finke, Luciana L. Almada, Jennifer M. Grants, Guolin Zhang, Martin E. Fernandez-Zapico, Alexandre Gaspar-Maia, Jeffrey Lancet, Rami Komrokji, Eric Haura, David A. Sallman, Gary W. Reuther, Aly Karsan, Uwe Rix, Mrinal M. Patnaik, Eric Padron
Journal: Clinical Cancer Research (2023)

Abstract Purpose: Preclinical studies in myeloid neoplasms have demonstrated efficacy of bromodomain and extra-terminal protein inhibitors (BETi). However, BETi demonstrates poor single-agent activity in clinical trials. Several studies suggest that combination with other anticancer inhibitors may enhance the efficacy of BETi. Experimental Design: To nominate BETi combination therapies for myeloid neoplasms, we used a chemical screen with therapies currently in clinical cancer development and validated this screen using a panel of myeloid cell line, heterotopic cell line models, and patient-derived xenograft models of disease. We used standard protein and RNA assays to determine the mechanism responsible for synergy in our disease models. Results: We identified PIM inhibitors (PIMi) as therapeutically synergistic with BETi in myeloid leukemia models. Mechanistically, we show that PIM kinase is increased after BETi treatment, and that PIM kinase upregulation is sufficient to induce persistence to BETi and sensitize cells to PIMi. Furthermore, we demonstrate that miR-33a downregulation is the underlying mechanism driving PIM1 upregulation. We also show that GM-CSF hypersensitivity, a hallmark of chronic myelomonocytic leukemia (CMML), represents a molecular signature for sensitivity to combination therapy. Conclusions: Inhibition of PIM kinases is a potential novel strategy for overcoming BETi persistence in myeloid neoplasms. Our data support further clinical investigation of this combination.
Surgery management of oral cavity premalignancy needs risk stratification and randomized controlled trials
Authors: Wei Liu, Xi Yang, Linjun Shi, Xuemin Shen
Journal: International Journal of Surgery (2023)

aDepartment of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China bCollege of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China cDepartment of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai 200011, China. Tel.: +86 21 23271699. E-mail address: [email protected] (X. Yang). *Corresponding author. Address: Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai 200011, China. Tel.: +86 21 63162851. E-mail address: [email protected] (L. Shi). *Corresponding author. Address: Shanghai Jiao Tong University School of Medicine CHINA. E-mail address: [email protected] (X. Shen). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0/
A retrospective cohort study of differential attainment, COVID and chaos: taking the difference out of a terrible trinity
Authors: Osian P. James, Katie Mellor, Oliver Luton, David B.T. Robinson, Leona Walsh, Sarah Hemington-Gorse, Richard J. Egan, Wyn G. Lewis
Journal: International Journal of Surgery (2023)

This study aimed to evaluate core surgical training (CST) differential attainment related to coronavirus disease 2019 (COVID-19), gender and ethnicity. The hypothesis was that COVID-19 adversely influenced CST outcomes.A retrospective cohort study of 271 anonymised CST records was undertaken at a UK Statutory Education Body. Primary effect measures were Annual Review of Competency Progression Outcome (ARCPO), Membership of the Royal College of Surgeons (MRCS) examination pass and Higher Surgical Training National Training Number (NTN) appointment. Data were collected prospectively at ARCP and analysed with non-parametric statistical methods in SPSS.CSTs numbering 138 completed training pre-COVID and 133 peri-COVID. ARCPO 1, 2 and 6 were 71.9% pre-COVID versus 74.4% peri-COVID ( P =0.844). MRCS pass rates were 69.6% pre-COVID versus 71.1% peri-COVID ( P =0.968), but NTN appointment rates diminished (pre-COVID 47.4% vs. peri-COVID 36.9%, P =0.324); none of the above varied by gender or ethnicity. Multivariable analyses by three models revealed: ARCPO was associated with gender [m:f 1:0.87, odds ratio (OR) 0.53, P =0.043] and CST theme (Plastics vs. General OR 16.82, P =0.007); MRCS pass with theme (Plastics vs. General OR 8.97, P =0.004); NTN with the Improving Surgical Training run-through programme (OR 5.00, P <0.001). Programme retention improved peri-COVID (OR 0.20, P =0.014) with pan University Hospital rotations performing better than Mixed or District General-only rotations (OR 6.63, P =0.018).Differential attainment profiles varied 17-fold, yet COVID-19 did not influence ARCPO or MRCS pass rates. NTN appointment fell by one-fifth peri-COVID, but overall training outcome metrics remained robust despite the existential threat.
Extension of resection after positive intraoperative pathology during surgery for gastric and gastroesophageal junction adenocarcinoma: a retrospective cohort study
Authors: Patrick S. Plum, Atakan G. Barutcu, Aylin Pamuk, Christoph Mallmann, Seung-Hun Chon, Costanza Chiapponi, Martin Dübbers, Martin Hellmich, Stefan P. Moenig, Alexander Quaas, Arnulf H. Hoelscher, Christiane J. Bruns, Hakan Alakus
Journal: International Journal of Surgery (2023)

Residual tumor at the resection margins after surgery for gastric and gastroesophageal junction (GEJ) adenocarcinoma is a known prognostic factor. In this single-center, retrospective cohort study in a tertiary referral center, the authors aimed to evaluate the relevance of intraoperative pathology consultation (IOC) and consecutive extension of surgery on patient survival.Of 737 consecutive patients undergoing (sub)total gastrectomy for gastric or GEJ adenocarcinoma, 679 cases with curative intent surgery between 05/1996 and 03/2019 were included. Patients were categorized into: R0 without further resection (direct R0), R0 after positive IOC and extension of resection (converted R0), and R1.IOC was performed in 242 (35.6%) patients, in 216 (89.3%) at the proximal resection margin. Direct R0-status was achieved in 598 (88.1%), converted R0 in 26 (3.8%) of 38 (5.6%) patients with positive IOC and R1 in 55 (8.1%) patients. The median follow-up was 29 months for surviving patients. 3-year survival rate (3-YSR) was significantly higher for direct R0 compared to converted R0 with 62.3% compared to 21.8% (hazard ratio=0.298; 95% CI=0.186-0.477, P <0.001). 3-YSR was similar between converted R0 and R1 (21.8 vs. 13.3%; hazard ratio =0.928; 95% CI=0.526-1.636, P =0.792). In multivariate analysis, advanced T ( P <0.001), N ( P <0.001), R ( P =0.003), and M1 status ( P <0.001) were associated with worse overall survival.IOC and consecutive extended resection for positive resection margins in gastrectomy for the proximal gastric and GEJ adenocarcinoma does not achieve long-term survival benefits in advanced tumor stages.
Discriminant ability of the shock index, modified shock index, and reverse shock index multiplied by the Glasgow coma scale on mortality in adult trauma patients: a PATOS retrospective cohort study
Authors: Tse-Hao Chen, Meng-Yu Wu, Sang Do Shin, Sabariah F. Jamaluddin, Do Ngoc Son, Ki Jeong Hong, Sun Jen-Tang, Hideharu Tanaka, Chien-Han Hsiao, Shang-Lin Hsieh, Ding-Kuo Chien, Weide Tsai, Wen-Han Chang, Wen-Chu Chiang
Journal: International Journal of Surgery (2023)

The shock index (SI) predicts short-term mortality in trauma patients. Other shock indices have been developed to improve discriminant accuracy. The authors examined the discriminant ability of the SI, modified SI (MSI), and reverse SI multiplied by the Glasgow Coma Scale (rSIG) on short-term mortality and functional outcomes.The authors evaluated a cohort of adult trauma patients transported to emergency departments. The first vital signs were used to calculate the SI, MSI, and rSIG. The areas under the receiver operating characteristic curves and test results were used to compare the discriminant performance of the indices on short-term mortality and poor functional outcomes. A subgroup analysis of geriatric patients with traumatic brain injury, penetrating injury, and nonpenetrating injury was performed.A total of 105 641 patients (49±20 years, 62% male) met the inclusion criteria. The rSIG had the highest areas under the receiver operating characteristic curve for short-term mortality (0.800, CI: 0.791-0.809) and poor functional outcome (0.596, CI: 0.590-0.602). The cutoff for rSIG was 18 for short-term mortality and poor functional outcomes with sensitivities of 0.668 and 0.371 and specificities of 0.805 and 0.813, respectively. The positive predictive values were 9.57% and 22.31%, and the negative predictive values were 98.74% and 89.97%. rSIG also had better discriminant ability in geriatrics, traumatic brain injury, and nonpenetrating injury.The rSIG with a cutoff of 18 was accurate for short-term mortality in Asian adult trauma patients. Moreover, rSIG discriminates poor functional outcomes better than the commonly used SI and MSI.
Trends in Illicit Ketamine Seizures in the US From 2017 to 2022
Authors: Joseph J. Palamar, Samuel T. Wilkinson, Thomas H. Carr, Caroline Rutherford, Linda B. Cottler
Journal: JAMA Psychiatry (2023)

This cross-sectional study evaluates trends in the number and weight of illicit ketamine seizures in the US from 2017 to 2022.
Analysis of prognostic factors and establishment of prognostic model for primary mediastinal germ cell tumors: a case controlled study
Authors: Changsen Leng, Yingying Cui, Zihang Mai, Rui Chen, Jianye Yuan, Kexi Wang, Jing Wen, Jianhua Fu, Qianwen Liu
Journal: International Journal of Surgery (2023)

The overall prognosis of primary mediastinal germ cell tumors (PMGCTs) is poor and the associated prognostic factors are not fully understood. Our goal was to investigate the prognostic factors of PMGCTs and to develop a validated prognostic prediction model.A total of 114 PMGCTs with specific pathological types were included in this study. Clinicopathological characteristics of nonseminomatous PMGCTs and mediastinal seminomas were compared using the χ2 or Fisher's exact test. Independent prognostic factors of nonseminomatous PMGCTs screened using the univariate and multivariate Cox regression analysis were then used to generate a nomogram. The predictive performance of the nomogram was evaluated using the concordance index, decision curve, and the area under the receiver operating characteristic curve (AUC) and validated by bootstrap resampling. The Kaplan-Meier curves of independent prognostic factors were analyzed.This study included 71 cases of nonseminomatous PMGCTs and 43 cases of mediastinal seminomas. The 3-year overall survival rates for nonseminomatous PMGCTs and mediastinal seminomas patients were 54.5 and 97.4%, respectively. The overall survival prognostic nomogram for nonseminomatous PMGCTs was established by integrating independent prognostic factors, including the Moran-Suster stage, white blood cell, hemoglobin, and platelet-lymphocyte ratio. The nomogram demonstrated good performance with a concordance index of 0.760 and the 1-year and 3-year AUC values of 0.821 and 0.833, respectively. These values were better than those of the Moran-Suster stage system. The bootstrap validation had an AUC of 0.820 (0.724-0.915) and showed a well-fitting calibration curve. Besides, patients with mediastinal seminomas showed favorable clinical outcomes and all the nine patients received neoadjuvant therapy and postoperative surgery achieved pathological complete response.A nomogram based on staging and blood routine examination results was established to accurately and consistently predict the prognosis of patients with nonseminomatous PMGCTs.
Emerging organoid-immune co-culture models for cancer research: from oncoimmunology to personalized immunotherapies
Authors: Luc Magré, Monique M A Verstegen, Sonja Buschow, Luc J W van der Laan, Maikel Peppelenbosch, Jyaysi Desai
Journal: Journal for ImmunoTherapy of Cancer (2023)

In the past decade, treatments targeting the immune system have revolutionized the cancer treatment field. Therapies such as immune checkpoint inhibitors have been approved as first-line treatment in a variety of solid tumors such as melanoma and non-small cell lung cancer while other therapies, for instance, chimeric antigen receptor (CAR) lymphocyte transfer therapies, are still in development. Although promising results are obtained in a small subset of patients, overall clinical efficacy of most immunotherapeutics is limited due to intertumoral heterogeneity and therapy resistance. Therefore, prediction of patient-specific responses would be of great value for efficient use of costly immunotherapeutic drugs as well as better outcomes. Because many immunotherapeutics operate by enhancing the interaction and/or recognition of malignant target cells by T cells, in vitro cultures using the combination of these cells derived from the same patient hold great promise to predict drug efficacy in a personalized fashion. The use of two-dimensional cancer cell lines for such cultures is unreliable due to altered phenotypical behavior of cells when compared with the in vivo situation. Three-dimensional tumor-derived organoids, better mimic in vivo tissue and are deemed a more realistic approach to study the complex tumor-immune interactions. In this review, we present an overview of the development of patient-specific tumor organoid-immune co-culture models to study the tumor-specific immune interactions and their possible therapeutic infringement. We also discuss applications of these models which advance personalized therapy efficacy and understanding the tumor microenvironment such as: (1) Screening for efficacy of immune checkpoint inhibition and CAR therapy screening in a personalized manner. (2) Generation of tumor reactive lymphocytes for adoptive cell transfer therapies. (3) Studying tumor-immune interactions to detect cell-specific roles in tumor progression and remission. Overall, these onco-immune co-cultures might hold a promising future toward developing patient-specific therapeutic approaches as well as increase our understanding of tumor-immune interactions.
Limited Evidence Backs Antidepressant Use for Managing Chronic Pain
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genomic hallmarks and therapeutic implications of G0 cell cycle arrest in cancer
Authors: Anna J. Wiecek, Stephen J. Cutty, Daniel Kornai, Mario Parreno-Centeno, Lucie E. Gourmet, Guidantonio Malagoli Tagliazucchi, Daniel H. Jacobson, Ping Zhang, Lingyun Xiong, Gareth L. Bond, Alexis R. Barr, Maria Secrier
Journal: Genome biology (2023)

Therapy resistance in cancer is often driven by a subpopulation of cells that are temporarily arrested in a non-proliferative G0 state, which is difficult to capture and whose mutational drivers remain largely unknown.
Error in Diagnosis and Text
Authors: Robert King, Ramil Goel
Journal: JAMA Cardiology (2023)

To the Editor We write to explain an error that occurred in our Clinical Challenge, "A Case of Right Bundle Branch Block With Changing Axis," 1 published online November 30, 2022, and in the February issue of JAMA Cardiology.The article features a patient with right bundle branch block (RBBB) with apparent shifting of axis of ventricular activation.The astute readers of the journal brought attention to the fact that the QRS morphology of the leads aVF and aVL on the 2 electrocardiograms (ECGs) appeared to have been reversed.This finding indicated that erroneous lead reversal could explain the apparent shift in QRS axis between the 2 ECGs.This led us to review the patient's medical record and multiple ECGs, and we did indeed find only 1 ECG showing leftward axis (rS pattern in lead III, Rs in lead I-read as RBBB/left anterior fascicular block).The other ECGs show RBBB and rightward axis (read as RBBB/left posterior fascicular block).These findings suggest that lead reversal is indeed part of the differential for the switch in axis of ventricular activation.Given the findings of only 1 ECG showing leftward axis and leads aVF and aVL looking so similar, lead reversal is the more likely cause of the apparent change in axis.We have corrected the article to reflect the likelihood of inadvertent lead reversal manifesting as changed QRS axis.From the patient's perspective, there were prior ECGs with atrial fibrillation and slow ventricular rates of 40 to 50 beats per minute associated with symptoms.He now paces 85% of the time through his leadless pacemaker and has improved symptomatically.Therefore, we believe the pacemaker was justified even if the patient may not have had trifascicular conduction disease.We believe this case holds educational value and emphasizes the importance of considering lead reversal in the differential of changing axis of QRS activation in addition to true conduction abnormalities.This case also reminds us of the importance of alert and aware readers who review pub-lished literature critically and help all of us learn.
Matters arising: authors of research papers must cautiously use ChatGPT for scientific writing
Authors: Arman Shafiee
Journal: International Journal of Surgery (2023)

Department of Psychiatry and Mental Health, Alborz University of Medical Sciences, Karaj, Iran. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article Published online ■ ■ *Corresponding author. Address: Alborz University of Medical Sciences, Taleghani Boulevard, Taleghani Square, Karaj, Iran. Postal code: 3149779453. E-mail address: [email protected] (A. Shafiee). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Trends in Use of Robotic Surgery for Privately Insured Patients and Medicare Fee-for-Service Beneficiaries
Authors: Sidra N. Bonner, Jyothi R. Thumma, Justin B. Dimick, Kyle H. Sheetz
Journal: JAMA Network Open (2023)

This cohort study evaluates trends in the adoption of robotic surgery among Medicare beneficiaries and privately insured patients for common general surgical procedures.
Exploring the clinical capabilities and limitations of ChatGPT: a cautionary tale for medical applications
Authors: Sheng Li
Journal: International Journal of Surgery (2023)

Department of Anorectal Surgery, Ningbo No.2 Hospital, Ningbo, Zhejiang, China The author has no funding to declare. Category Research Letter The author declares no conflict of interest. The template data collection forms are available from the corresponding author (L.S) upon reasonable request. No primary data was generated and reported in this manuscript. Therefore, data has not become available to any academic repository. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Ningbo No.2 Hospital, CHINA. E-mail address: [email protected] (S. Li). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/