tbuckley/cabot-search huggingface dataset:
Highlights of This Issue
Journal: Clinical Cancer Research (2013)

Although the ETS2 gene is involved in an array of intracellular pathways through its canonical transcription factor function, its role in non-small cell lung cancer (NSCLC) pathogenesis remains elusive.Kabbout and colleagues studied the expression and global function of ETS2 in human NSCLC tissues and multiple lung cancer cell lines.Decreased ETS2 expression was prevalent in lung tumors, predicted shorter time to patient recurrence, and heightened lung cancer cell proliferation, migration, and invasion through activation of HGF signaling and MET oncogene function.Decreased ETS2 expression and function may represent a novel mechanism for uncontrolled HGF/MET signaling and activity in NSCLC.
Diabetes and Obesity
Authors: David L. Horwitz
Journal: JAMA (1982)

The person with diabetes is more likely to be obese than is his nondiabetic peer. Similarly, there is a greater probability of diabetes occurring in an obese person. It is assumed frequently, therefore, that the two are related causally. However, as O'Sullivan points out in this issue ofThe Journal(p 949), there is a dearth of prospective data on this common problem. O'Sullivan has, since 1954, studied groups of women who received prenatal care at Boston City and Boston Lying-In hospitals. Those whose glucose tolerance was abnormal during pregnancy, but who had a normal postpartum oral glucose tolerance test (OGTT) result, had subsequent development of diabetes more frequently than did women who had normal OGTT results during pregnancy. The increased risk for women with transient gestational diabetes for development of diabetes later in life is, of course, well recognized.<sup>1</sup>The new analysis of the data, in terms of body
Financing Research by Disease Categories
Authors: Irvine H. Page
Journal: JAMA (1974)

EVER since the federal government became involved in large-scale spending to support research, the pattern has been for the head of each institute of the National Institutes of Health (NIH) to plead his budget before Congress. Congress, thereby, got a liberal education in the ways of medical research. Preceding the various pleas, some lobbying inevitably occurred, and the directors were more or less successful according to their persuasiveness and the number of their congressional friends. The entire appeal was under the firm hand of the then director of the NIH, James Shannon. However, when he retired, times and sentiments changed. To most practicing physicians, this pattern was of little interest. Three years ago, however, a radical change occurred that should have triggered concern. The campaign for financial support of the National Cancer Institute changed radically. Highly skilled lobbyists, exemplified by Mike Gorman, backed by potent financial interests with close friendships
Use of an Established Cat Cell Line for Investigation and Quantitation of Feline Oncornaviruses
Journal: JNCI Journal of the National Cancer Institute (1972)

Susceptibility of a continuous cat kidney cell line of Crandell (CCC) to focus formation by a feline leukemia pseudotype of murine sarcoma virus, MSV(FeLV), was compared to that of feline embryonic fibroblast (FEF) cultures. CCC appeared to be nearly as susceptible to infection with MSV(FeLV) as FEFi virus titers on CCC were only three-fold lower than those on FEF. The MSV(FeLV) stock showed a characteristic “two-hit” titration pattern when assayed in CCC as well as in FEF with or without addition of diethylaminoethyl (DEAE)-dextran (D) to the assay plates. In the presence of added FeLV, the number of foci formed by MSV(FeLV) was increased and the titration pattern became essentially “one-hit.” Pretreatment of both CCC and FEF cultures with DEAE-D enhanced by threefold to four-fold the focus formation by MSV(FeLV) either alone or with exogenous FeLV. Preinfection of CCC cultures with FeLV or the Gardner-Arnstein strain of feline sarcoma virus induced resistance to challenge with MSV(FeLV). In addition, colonies of transformed cells were produced in semisolid agar suspension cultures after infection of CCC with MSV(FeLV).
THE AMERICAN ACADEMY OF MEDICINE.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Practical Medicine Series.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer Mortality in a Cohort of Naval Shipyard Workers in Hawaii: Early Findings&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Kolonel, Laurence N., Hirohata, Tomio, Chappell, Bertha V., Viola, Francis V., Harris, Donald E.
Journal: JNCI Journal of the National Cancer Institute (1980)

Journal Article Cancer Mortality in a Cohort of Naval Shipyard Workers in Hawaii: Early Findings Get access Laurence N. Kolonel, Laurence N. Kolonel 3Epidemiology Program, Cancer Center of Hawaii, University of Hawaii, Suite 407, 1236 Lauhala St., Honolulu, Hawaii 96813. Search for other works by this author on: Oxford Academic PubMed Google Scholar Tomio Hirohata, Tomio Hirohata 3Epidemiology Program, Cancer Center of Hawaii, University of Hawaii, Suite 407, 1236 Lauhala St., Honolulu, Hawaii 96813. Search for other works by this author on: Oxford Academic PubMed Google Scholar Bertha V. Chappell, Bertha V. Chappell 3Epidemiology Program, Cancer Center of Hawaii, University of Hawaii, Suite 407, 1236 Lauhala St., Honolulu, Hawaii 96813. Search for other works by this author on: Oxford Academic PubMed Google Scholar Francis V. Viola, Francis V. Viola 5Department of Public Health Sciences, School of Public Health, University of Hawaii, Honolulu, Hawaii 96822. Search for other works by this author on: Oxford Academic PubMed Google Scholar Donald E. Harris Donald E. Harris 3Epidemiology Program, Cancer Center of Hawaii, University of Hawaii, Suite 407, 1236 Lauhala St., Honolulu, Hawaii 96813. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 64, Issue 4, April 1980, Pages 739–743, https://doi.org/10.1093/jnci/64.4.739 Published: 01 April 1980 Article history Received: 25 May 1979 Accepted: 04 September 1979 Published: 01 April 1980
Suppression of Natural Killer Cell Activity by Chicken α-Fetoprotein in Japanese Quails&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: Akio Yamada, Masanori Hayami
Journal: JNCI Journal of the National Cancer Institute (1983)

Spleen cells taken from quails treated with chicken α-fetoprotein (Ch-AFP) showed reduced natural killer (NK) activity as did spleen cells taken from quails treated with chicken amniotic fluid (ChAmF) in which the presence of Ch-AFP was demonstrated by a gel precipitation test. The Ch-AFP-induced reduction of NK activity was shown to be mediated by suppressor cells. In addition, Ch-AFP-treated quails developed tumors with shorter latent periods than those of the tumors that developed in untreated quails after inoculation with Rous sarcoma virus, as was true for ChAmF-treated quails.
Silicone Breast Implants and Sclerodermalike Esophageal Disease in Breast-fed Infants-Reply
Authors: Jeremiah J. Levine
Journal: JAMA (1996)

<h3>In Reply.</h3> —Dr Epstein asserts that we stated that we systematically excluded mothers with scleroderma from our study. Actually, the article states, "The mothers had all been asymptomatic while breast-feeding, and none subsequently developed scleroderma." Data on the mothers in the study were collected in a manner using standard history-taking techniques. We were unaware that any mother had been diagnosed with scleroderma. Additionally, on examination, no mother in the study was found to have scleroderma (ie, hard skin). We agree with Epstein that the reliability of diagnoses cited in court may be questioned, and some patients who have been labeled as having scleroderma may not satisfy diagnostic criteria. It would be improper of us to comment specifically on any individual whose children participated in the study. Even if one or more of the mothers had scleroderma and we were unaware of the diagnosis, the likelihood of the observed abnormalities in
Complications of Echinococcus Cyst Rupture
Authors: Carl F. Schiller
Journal: JAMA (1966)

ECHINOCOCCOSIS is uncommon in the continental United States<sup>1</sup>; because the disease is difficult to diagnose, the characteristic cysts of the cestode<i>Echinococcus granulosus</i>are often approached surgically without prior diagnosis and occasionally are ruptured. An<i>Echinococcus</i>cyst may be present in any organ of the body, but it is most frequently situated in the liver or the lung.<sup>1</sup>Rupture or incision may result in the spillage of hydatid material, ie, detached germinal layer, brood capsules, and scolices, into the peritoneal or thoracic cavities and may result in an immediate anaphylactic reaction or in the long-term development of secondary cysts in contaminated sites.<sup>1</sup> Several cases of traumatic or surgical rupture of hydatid cysts followed by secondary-cyst formation have been reported.<sup>2-5</sup>Frequently, spillage followed attempts to aspirate the cysts. Dew<sup>6</sup>stated that secondary-cyst formation is a common and constant risk to all patients with intra-abdominal hydatid cysts.
Nutrition and Clinical Dietetics.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oral Abstract Sessions
Journal: Allergy (2014)

Background: The immunogenicity and efficacy of allergen vaccines highly depend on the capacity of dendritic cells (DCs) to capture them and to induce proper immune responses.The aim of this work was to compare the ability of DCs to internalize and mount immune responses to grass pollen (N), glutaraldehyde-polymerised allergoids (P) and glutaraldehyde-polymerised allergoids coupled to mannan (PM) extracts.Method: Phleum pratense pollen extracts N, P and PM were from Inmunotek.PM was generated by innovative methods for coupling mannan to glutaraldehyde-modified allergens.Human monocytes were differentiated to DCs with IL-4/GM-CSF.Flow cytometry and confocal microscopy was used to determine allergen capture with and without specific blocking antibodies.Co-culture experiments, real-time quantitative PCR, ELISA and ELISPOT were performed.BALB/c mice were immunised with the different extracts and antibody levels in serum, proliferation of splenocytes and cytokine production were determined.Results: PM showed enhanced capacity to be captured by human DCs than N or P. The uptake mechanism was partially depending on receptor-mediated internalization involving mannose receptor and DC-SIGN.DCs stimulated with N, P and PM expressed high levels of HLA-DR, CD86 and CD83.PM-treated DCs produced significant higher levels of IL-6 and IL-10 than N-or P-treated DCs.Allogeneic and allergen-specific co-cultures showed that PM-treated DCs polarize T cells producing higher levels of IFNgamma and IL-10 and lower levels of IL-5 or IL-4 than N-or P-treated DCs.Splenocytes from mice immunised with PM showed higher proliferation rates than those from mice immunised with N or P and showed a Th1 cytokine-signature with high levels of IL-10.Conclusion: Grass pollen allergoids conjugated to mannan show an enhanced immunogenicity and capacity to induce healthy T cell responses to allergens.
Food Inspection and Analysis, for the Use of Public Analysts, Health Officers, Sanitary Chemists and Food Economists.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preoperative staging of local invasion in rectal cancer using endoluminal ultrasound
Authors: J Beynon, A M Roe, D M A Foy, J Lchanner, J Virjee, N J McC Mortensen
Journal: Journal of the Royal Society of Medicine (1987)

Digital examination is the most commonly used method of assessing local invasion in rectal cancer, but it is highly subjective and accuracy is related to surgical experience. The use of transrectal ultrasound in the preoperative staging of rectal cancer has been assessed in 51 patients with histologically proven rectal cancers. Results showed a high degree of correlation when compared with postoperative histopathology (r = 0.91, P &lt; 0.001). Invasion beyond the muscularis propria was predicted with a sensitivity of 97%. specificity of 92% and predictive value of 97%.
Linking chromosome defects with cancer
Authors: Beverly Merz
Journal: JAMA (1983)

"I am thoroughly exhausted from the excitement." The speaker: H. John Evans, MB, chair, Medical Research Council Clinical and Population Cytogenetics Unit, Western General Hospital, Edinburgh, Scotland. The occasion: a summary of a recent two-day symposium in Chicago entitled "Chromosomes and Cancer: From Molecules to Man." The symposium, organized by the University of Chicago, was the fifth annual seminar on cancer research sponsored by Bristol-Myers Company, New York. And this year, perhaps more than ever before, the excitement extended well beyond the speaker's podium. Those in the audience seemed to sense that they were witness to, or perhaps participants in, a new era of cancer research. Janet D. Rowley, MD, professor of hematology and oncology at the University of Chicago, put this new era into historical perspective, terming it the third technological chapter in research linking cancer with chromosomal abnormalities. This refers not only to chromosome abnormalities that are found
Increased Adenosine Deaminase (ADA) Activity and a Shift From ADA-Dependent to ADA-Independent Phases During T-Cell Activation: A Paradox&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Bruce C. Veit, Marvin Fishman, Thomas Look
Journal: JNCI Journal of the National Cancer Institute (1984)

During activation of WF rat splenic T-cells, a change occurs with respect to susceptibility to a toxic accumulation of adenosine or deoxyadenosine (dADO) in the presence of adenosine deaminase (ADA) blockade. Addition of nucleoside 1 hour after the initiation of a concanavalin A response in the presence of 2′deoxycoformycin (DCF) markedly inhibited the response, whereas delay of addition of the nucleoside for 24–48 hours resulted in minimal or no inhibition. Inhibition was not simply the result of prolonged incubation of cells in the presence of nucleoside and was apparently not attributable to an effect on proliferating cells. Addition of interleukin 2 (IL-2) to cultures containing DCF and dADO did not reverse the inhibitory effect, which suggests that IL-2-producing T-cells also were not the target of nucleoside toxicity. A twofold increase in ADA activity that occurred during T-cell activation was nonessential for the survival of mitogen-activated T-cells in the presence of toxic concentrations of dADO and did not account for an apparent increased resistance of these cells to nucleoside toxicity. These paradoxical observations prompted an analysis of ADA activity in various populations of activated T-cells enriched with cells in G0/G1, S, or G2+M cell-cycle phases, which indicated that increased ADA activity was not associated with a specific period during cell-cycle traverse, but, rather, coincided with cell enlargement in preparation for mitosis. In conclusion, either an early event in T-cell mitogenesis is highly susceptible to nucleoside toxicity or a mechanism independent of ADA is acquired during T-cell activation that allows proliferating T-cells to resist toxic concentrations of nucleoside.
US Cities Struggle to Implement Needle Exchanges Despite Apparent Success in European Cities
Authors: Chris Anne Raymond
Journal: JAMA (1988)

PHILOSOPHICAL arguments are seldom settled by numbers. In the case of drug abusers and acquired immunodeficiency syndrome (AIDS), many public health experts say the numbers support their view that, in the absence of effective means to eliminate intravenous (IV) substance abuse, the next best thing is to help addicts inject more safely. Opponents say that distributing free needles and syringes will encourage drug use and send the wrong message at a time when the nation appears increasingly concerned about the impact of illicit substance abuse. After numerous false starts, two cities in this country—New York and Portland, Ore—are poised to put the issue to the test. But given the politically charged environment, it is far from certain that the results of those tests will change minds. They may save lives, though. As many as 4.5 million men and women are "in the direct line of fire"—as IV drug users or
Highlights of This Issue
Journal: Clinical Cancer Research (2017)

Metabolomic Profiles Predictive of Breast Cancer RecurrenceDetection of signals of micrometastatic disease in early breast cancer may improve risk stratification, and serum metabolomic profiles of early breast cancer patients have been shown to be predictive of relapse in a single institution series.Taking samples from a multicentre, phase III adjuvant breast cancer trial in premenopausal women, Hart and colleagues used NMR spectra of preoperative serum samples to build a model that identified women at higher risk of relapse, independent of standard risk factors.Metabolomic analysis has the potential to improve disease staging and prognostication and allow better tailoring of adjuvant therapies.
Pediatrics; the Hygienic and Medical Treatment of Children.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal