tbuckley/cabot-search huggingface dataset:
Diseases of the Nose, Throat and Ear, Medical and Surgical.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EXTERNALIZATION OF CONDUCTOR CABLES IN QUICKSITE AND QUICKFLEX LEFT VENTRICULAR LEADS
Authors: Madhu Reddy, Ajay Vallakati, Pramod Janga, Suresh Sharma, Anand Pillai, Raghuveer Dendi, Martin Emert, Loren Berenbom, Rhean Linette Pimentel, Dhanunjaya Lakkireddy
Journal: Journal of the American College of Cardiology (2013)
Health Care Professionals and Fear of AIDS
Authors: Sylvain Fribourg
Journal: JAMA (1989)

<h3>To the Editor.—</h3> The authors of the commentary entitled "Why Fear Persists: Health Care Professionals and AIDS"1 have totally missed the reason why fear persists by health care professionals exposed to the risk of acquired immunodeficiency syndrome occupationally. The fear persists because there is no preventive vaccine for acquired immunodeficiency syndrome, there is no curative therapy for acquired immunodeficiency syndrome, and acquired immunodeficiency syndrome is uniformly 100% lethal.
Cost-effectiveness of Short-Course Zidovudine to Prevent Perinatal HIV Type 1 Infection in a Sub-Saharan African Developing Country Setting
Authors: Gordon Mansergh
Journal: JAMA (1996)

<h3>Objective.</h3> —To evaluate the cost-effectiveness of a short-course zidovudine program to prevent perinatal transmission of human immunodeficiency virus (HIV) type 1 in sub-Saharan African country settings. <h3>Design and Setting.</h3> —Several clinical trials of short-course zidovudine during pregnancy for prevention of perinatal transmission of HIV are under way in developing countries in sub-Saharan Africa. A decision model was used to examine the cost-effectiveness of zidovudine programs in a hypothetical 1-year birth cohort in a sub-Saharan African setting from the perspective of the health care system and of society. A completed short course of zidovudine was assumed to reduce perinatal HIV transmission from 25% to 16.5%, approximately one half of the effect of the longer-course zidovudine. Estimates of program costs, lifetime HIV-related health care costs, and lost productivity costs were derived from the published literature and from preliminary data available from sites of planned clinical trials. Sensitivity analyses were conducted on all relevant parameters. <h3>Main Outcome Measures.</h3> —Medical costs, lost productivity costs, program costs, cost savings, and incremental cost-effectiveness, expressed as cost per infant HIV infection prevented. <h3>Results.</h3> —The model estimated that a national zidovudine program in a setting with 12.5% HIV seroprevalence would reduce perinatal HIV incidence by 12% (4.9 infections per 1000 births). The cost to the health care system would be $3748 per infant HIV infection prevented. When productivity losses were included in the model, the cost decreases to $1115 per infant HIV infection prevented. The cost to implement a national zidovudine program including the cost of counseling, testing, and drugs, would be $2 million per 100 000 births or $20 per pregnant woman. In the base case, decreases in the cost of counseling and testing and increases in maternal HIV prevalence, zidovudine efficacy, and medical and lost productivity costs improved cost-effectiveness of the zidovudine program. <h3>Conclusions.</h3> —Assuming demonstrable efficacy of short-course zidovudine prevention of perinatal HIV, a national perinatal HIV prevention program with zidovudine in most sub-Saharan African country settings would reduce the incidence of infant HIV infection and, in some settings, provide societal savings; however, substantial initial investment in such programs will be required. Where health care resources are limited, as in these regions, allocation of resources to a perinatal zidovudine program will need to be considered in the context of resources required for other pressing medical care needs.
The Topographical Anatomy of the Thorax and Abdomen of the Horse.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Colonial Growth in Agar of Cells Derived From Adenovirus-Induced Hamster Tumors&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: McAllister, Robert M., Reed, George, Huebner, Robert J.
Journal: JNCI Journal of the National Cancer Institute (1967)

Journal Article Colonial Growth in Agar of Cells Derived From Adenovirus-Induced Hamster Tumors Get access Robert M. McAllister, Robert M. McAllister Departments of Pediatrics and Pathology, University of Southern California School od Medicine, Childrens Hospital of Los Angeles, Los Angeles, California 90027, and Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases4, Bethescla, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar George Reed, George Reed Departments of Pediatrics and Pathology, University of Southern California School od Medicine, Childrens Hospital of Los Angeles, Los Angeles, California 90027, and Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases4, Bethescla, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert J. Huebner Robert J. Huebner Departments of Pediatrics and Pathology, University of Southern California School od Medicine, Childrens Hospital of Los Angeles, Los Angeles, California 90027, and Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases4, Bethescla, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 39, Issue 1, July 1967, Pages 43–53, https://doi.org/10.1093/jnci/39.1.43 Published: 01 July 1967 Article history Received: 07 November 1966 Published: 01 July 1967
THE PHARMACOPEIA AND THE PHYSICIAN.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Modulation of Growth, Differentiation, and Mucous Glycoprotein Synthesis by Retlnyl Acetate in Cloned Carcinoma Cell Lines2, 3
Authors: Ann C. Marchok, Jeffrey N. Clark, Andres Klein-Szanto
Journal: JNCI Journal of the National Cancer Institute (1981)

Journal Article Modulation of Growth, Differentiation, and Mucous Glycoprotein Synthesis by Retlnyl Acetate in Cloned Carcinoma Cell Lines, Get access Ann C. Marchok, Ann C. Marchok Search for other works by this author on: Oxford Academic PubMed Google Scholar Jeffrey N. Clark, Jeffrey N. Clark Search for other works by this author on: Oxford Academic PubMed Google Scholar Andres Klein-Szanto Andres Klein-Szanto Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 66, Issue 6, June 1981, Pages 165–174, https://doi.org/10.1093/jnci/66.6.1165 Published: 01 June 1981 Article history Received: 09 September 1980 Accepted: 08 December 1980 Published: 01 June 1981
Use of Circulating Pregnancy-Specific β1 Glycoprotein as a Marker in Carcinoma of the Breast in Women&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: Saul W. Rosen, Ph.D., M.D.
 4, Mitchell H. Gail, M.D., Ph.D., Douglass C. Tormey
Journal: JNCI Journal of the National Cancer Institute (1982)

Pregnancy-specific β1, glycoprotein (SP1) was determined by radioimmunoassay in sera from 27 normal women, 33 women with benign breast disease, and 191 women with carcinoma of the breast, staged for extent of the disease. All diagnostic groups exhibited substantial overlap in SP1 values. Those with benign breast diseases tended to have values at least as high as those with cancer. Normal patients tended to have slightly lower values, but this difference may well have been due to the younger ages of the normal patients in our sample, because SP1 values tended to increase with age. Immunochemical dilutions of SP1 in the serum with the highest value (10.2 ng/ ml) did not differ significantly from standard placental SP1
Effect of Sodium Depletion on Renin Activity of Renal Venous Plasma in Renovascular Hypertension
Authors: Stanley E. Vermillion
Journal: JAMA (1969)

In a patient with renovascular hypertension, renal venous renin-activity determinations were carried out during normal sodium intake, after sodium depletion, and after sodium repletion. When the patient was eating a normal sodium diet, renal venous renin-activity levels failed to lateralize, a finding consistent with the results of isotope renography and two separated renal function studies. However, renal venous renin-activity ratios lateralized (ratios greater than 2:1) to the affected side when the patient's severe sodium depletion lasted for three days. From this finding, it was correctly predicted that relief of hypertension would follow nephrectomy for complete occlusion of a branch artery secondary to fibromuscular dysplasia. Acute sodium depletion increases the diagnostic sensitivity of renal venous renin-activity testing in the determination of functional significance of renovascular lesions in hypertensive patients.
Highlights from Recent Cancer Literature
Journal: Cancer Research (2013)

PIK3CA, which encodes the p110a catalytic subunit of phosphatidylinositol 3-kinase a, is frequently activated in human cancers and is therefore a potential target for therapy.Activating mutations, including E545K and H1047R, are the most common, but the specific mechanisms by which these 2 mutations exert their oncogenic effects may be distinct.E545 is within the helical domain, while H1047 is within the kinase domain.Hao and colleagues explore differences between p110a E545K and H1047R mutant proteins in oncogenic signaling.This interaction was shown not to require p85, a regulatory subunit that inhibits the enzymatic activity of p110a.Signal transduction in normal cells relies on the SH2 domains of p85 interacting with phospho-tyrosine residues on proteins such as insulin receptor substrate 1 (IRS1).Accordingly, the investigators first showed that helical domain mutant proteins, but not kinase mutant proteins, interacted with IRS1.They mapped the IRS1 domains required for p110a interaction and showed that IRS1 stabilized p110a.Consistent with the fact that membrane localization of p110a is required for activation, they provide evidence that the interaction between IRS1 and p110a E545K resulted in membrane localization.Using IRS1 knockout cells, they showed that the presence of IRS1 and its interaction with p110a E545K was required for robust tumor growth in vivo.They then used an 18-AA peptide ("stapled" to a macrocyclic derivative) from the E545K mutant protein to show that it disrupted the IRS1 interaction.Compared with the 18 AA wildtype peptide, the E545K mutant peptide specifically reduced phosphorylation of AKT as well as tumor growth in vivo.As an important control, this stapled peptide had no effect on the ability of the H1047K mutant to phosphorylate AKT.Essentially, the E545K mutation abrogated the need for interaction of p85, which in the absence of binding to proteins such as IRS1 would be inhibitory on p110a.Overall, these findings point to the disruption of the E545K mutant p110a -IRS1 interaction as a key target for therapy for patients whose tumors show this genetic lesion.
Health Care Use Among Young Children in Day Care
Authors: Marie C. McCormick
Journal: JAMA (1991)

Exposure of young children to group day-care settings increases the risk of illness and may result in higher use of medical care. These observations raise concerns that the use of such settings for early intervention programs for low—birth-weight infants may increase the already high burden of medical care costs incurred by these children and their families. To address the question of medical care use associated with center-based care, we examined the hospital-based and ambulatory care reported for participants of the Infant Health and Development Program. This project is a multisite randomized trial of an early intervention program for preterm low—birth-weight infants with an intervention including 2 years of center-based care. The Intervention group did not differ in hospital-based care and averaged only two more physicians' visits over the 3-year observation period than the comparison group. We conclude that early intervention programs involving high-quality group care are not accompanied by substantial increases in health care use. (<i>JAMA</i>. 1991;265:2212-2217)
Highlights from Recent Cancer Literature
Journal: Cancer Research (2013)

Platforms to detect and isolate circulating tumor cells (CTC) mark early systemic disease, monitor response, and may enable molecular characterization of metastatic disease.For patients without metastases (M0), tools are needed to determine those in whom metastases will develop.However, the limited numbers of CTCs, and the 1-10 mL volumes of blood used for their detection, have hampered reliability and reproducibility.Fischer and colleagues address these issues, using leukapheresis (LA), a clinical method to isolate mononuclear cells from large volumes of blood.LA efficiently detected cytokeratin-positive CTCs (>91% in breast cancer), recovering enough material to analyze somatic copy number variation (SCNV) as well.LA-based CTC enumeration and genomic characterization in M0 patients were also prognostic, as patients whose CTCs displayed >10 SCNVs, analyzed both retrospectively and prospectively, were prone to early metastatic relapse.Analysis of large volumes of blood enabled accurate estimation of CTC frequency in patients, ranging from $2 Â 10 3 to $8 Â 10 4 , as compared with studies using smaller volumes, which estimated 10 4 to 10 6 CTCs.This study applies a common clinical method to the CTC field and provides a model for clinical application and diagnosis.
Содержание метаболитов NO в желудочном соке больных хроническим рефлюкс-гастритом
Authors: A.N. Kovalenko
Journal: GASTROENTEROLOGY (2014)

Для выяснения роли нитросоединений в патогенезе поражения слизистой оболочки желудка исследованы концентрации нитратов и нитритов в желудочном соке у 65 больных хроническим рефлюкс-гастритом. Выявлено их выраженное повышение у большинства больных, особенно при атрофических и перестроечных процессах у больных с дуоденогастральным рефлюксом на фоне постхолецистэктомического синдрома. Патологические концентрации нитратов и нитритов в желудочном соке тесно связаны с Н.pylori-инфекцией, повышением уровня желчных кислот, гипергастринемией. Это может играть существенную роль в развитии и прогрессировании хронического рефлюкс-гастрита и гастроканцерогенеза.
Highlights of This Issue
Journal: Clinical Cancer Research (2016)

Resistance to aromatase inhibitors (AIs) is an ongoing clinical challenge in the treatment of breast cancer.To investigate the role of the estrogen receptor in AI resistance, Varešlija and colleagues conducted global ChIPsequencing analysis in AI-resistant breast cancer cells and profiled patient tumor samples before, during, and after AI therapy.The estrogen receptor rapidly adapted to AI therapy, developing estrogen-independent transcriptional activity; however, during later stages of resistant disease progression, activity and even expression of the estrogen receptor was frequently lost.This study highlights the need to reassess tumor status during disease progression.
Bacteriology and the Public Health.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Misleading Advertisements
Authors: Brian Vastag
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Readings in the Clinical Method in Psychology
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Examination of Waters and Water Supplies.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal