tbuckley/cabot-search huggingface dataset:
Emerging delivery systems based on aqueous two-phase systems: A review
Authors: Yaowen Zhang, Yankun Luo, Jingqi Zhao, Wenzhuo Zheng, Jun Zhan, Huaping Zheng, Feng Luo
Journal: Acta Pharmaceutica Sinica B (2023)

The aqueous two-phase system (ATPS) is an all-aqueous system fabricated from two immiscible aqueous phases. It is spontaneously assembled through physical liquid-liquid phase separation (LLPS) and can create suitable templates like the multicompartment of the intracellular environment. Delicate structures containing multiple compartments make it possible to endow materials with advanced functions. Due to the properties of ATPSs, ATPS-based drug delivery systems exhibit excellent biocompatibility, extraordinary loading efficiency, and intelligently controlled content release, which are particularly advantageous for delivering drugs in vivo. Therefore, we will systematically review and evaluate ATPSs as an ideal drug delivery system. Based on the basic mechanisms and influencing factors in forming ATPSs, the transformation of ATPSs into valuable biomaterials is described. Afterward, we concentrate on the most recent cutting-edge research on ATPS-based delivery systems. Finally, the potential for further collaborations between ATPS-based drug-carrying biomaterials and disease diagnosis and treatment is also explored.
Lymphatic endothelial transcription factor Tbx1 promotes an immunosuppressive microenvironment to facilitate post-myocardial infarction repair
Authors: Wenfeng Wang, Xiao Li, Xiaoning Ding, Shanshan Xiong, Zhenlei Hu, Xuan Lu, Kan Zhang, Heng Zhang, Qianwen Hu, Kaa Seng Lai, Zhongxiang Chen, Junjie Yang, Hejie Song, Ye Wang, Lu Wei, Zeyang Xia, Bin Zhou, Yulong He, Jun Pu, Xiao Liu, Rongqin Ke, Tao Wu, Chuanxin Huang, Antonio Baldini, Min Zhang, Zhen Zhang
Journal: Immunity (2023)
PB2607: OBESITY IMPAIRS RESPONSE TO FIRST-LINE HIGH-DOSE DEXAMETHASONE IN PATIENTS WITH PRIMARY IMMUNE THROMBOCYTOPENIA.
Authors: Gege Feng, Xiaoyu Zhang, Qiang Liu, Shuwen Wang, Jun Peng
Journal: HemaSphere (2023)

Topic: 32. Platelet disorders Background: Primary immune thrombocytopenia (ITP) is an acquired organ-specific autoimmune disorder characterized by a decreased peripheral platelet count. Considering the variable treatment response shown by patients with ITP, it is of critical need to determine which patients will benefit most from certain therapy option. Obesity has become a considerable public health challenge with the prevalence rising rapidly to 16.4% in China. Emerging evidence has demonstrated that obesity is correlated with negative treatment responses in multiple immune-related diseases. However, there is a knowledge gap regarding whether and how obesity alters the treatment response in ITP. Aims: We performed this retrospective study to evaluate the impact of obesity on treatment outcomes to high-dose dexamethasone (HD-DXM) therapy in a cohort of treatment-naïve adult patients with ITP. Methods: A total of 214 treatment-naïve ITP patients who received first-line HD-DXM therapy after admission at Qilu Hospital, Shandong University from January 2012 to August 2022 were included. We recorded the weight and height of individuals at admission and calculated body mass index (BMI) to evaluate obesity. According to the recommended BMI cut-offs for Chinese adults, patients were classified as non-obese (BMI < 28.0 kg/m2), and obese (BMI ≥28 kg/m2). The primary endpoints were initial and sustained responses. The second endpoint were duration of response and relapse. All the patients who showed initial response were followed up. The date of last follow-up was February 20, 2023, the date of last contact, or the date of relapse. Results: Among the 214 patients, 79.4% (n = 170) were non-obese, 20.6% (n = 44) were obese. Obese patients showed significantly lower initial overall response (obese vs. non-obese: 52.3% vs. 79.4%, p < 0.001) and complete response ([CR], 27.3% vs. 62.9%, p < 0.001) rates. The same trend was also observed in the 6-month sustained responses (22.7.0% vs. 47.1%, p = 0.034; sustained CR, 9.1% vs. 36.4%, p = 0.012). The Kaplan-Meier analysis revealed a shortened duration of response in the obese group than in non-obese group (median duration of response, 1 month vs. 6 months, p = 0.001). In a multivariable Cox analysis, obesity was an independent risk factor for relapse (HR = 2.154; 95% CI = 1.290–3.595; p = 0.003). Summary/Conclusion: In conclusion, this study provides a new perspective on the association between obesity and ITP, for which there is extremely limited data. Patients with obesity appear to show impaired early and long-term responses, a shorter duration of response, and a higher risk of relapse to first line HD-DXM treatment. More stratified approaches according to BMI status should be considered in practice. Keywords: Obesity, Immune thrombocytopenia (ITP)
Prototypical few-shot segmentation for cross-institution male pelvic structures with spatial registration
Authors: Yiwen Li, Yunguan Fu, Iani J.M.B. Gayo, Qianye Yang, Zhe Min, Shaheer U. Saeed, Wen Yan, Yipei Wang, J. Alison Noble, Mark Emberton, Matthew J. Clarkson, Henkjan Huisman, Dean C. Barratt, Victor A. Prisacariu, Yipeng Hu
Journal: Medical Image Analysis (2023)

The prowess that makes few-shot learning desirable in medical image analysis is the efficient use of the support image data, which are labelled to classify or segment new classes, a task that otherwise requires substantially more training images and expert annotations. This work describes a fully 3D prototypical few-shot segmentation algorithm, such that the trained networks can be effectively adapted to clinically interesting structures that are absent in training, using only a few labelled images from a different institute. First, to compensate for the widely recognised spatial variability between institutions in episodic adaptation of novel classes, a novel spatial registration mechanism is integrated into prototypical learning, consisting of a segmentation head and an spatial alignment module. Second, to assist the training with observed imperfect alignment, support mask conditioning module is proposed to further utilise the annotation available from the support images. Extensive experiments are presented in an application of segmenting eight anatomical structures important for interventional planning, using a data set of 589 pelvic T2-weighted MR images, acquired at seven institutes. The results demonstrate the efficacy in each of the 3D formulation, the spatial registration, and the support mask conditioning, all of which made positive contributions independently or collectively. Compared with the previously proposed 2D alternatives, the few-shot segmentation performance was improved with statistical significance, regardless whether the support data come from the same or different institutes.
Recent advances in Fe-based bioresorbable stents: Materials design and biosafety
Authors: Yang Zhang, Charles Roux, Aymeric Rouchaud, Anne Meddahi-Pellé, Virginie Gueguen, Claire Mangeney, Fan Sun, Graciela Pavon-Djavid, Yun Luo
Journal: Bioactive Materials (2023)

Fe-based materials have received more and more interests in recent years as candidates to fabricate bioresorbable stents due to their appropriate mechanical properties and biocompatibility. However, the low degradation rate of Fe is a serious limitation for such application. To overcome this critical issue, many efforts have been devoted to accelerate the corrosion rate of Fe-based stents, through the structural and surface modification of Fe matrix. As stents are implantable devices, the released corrosion products (Fe2+ ions) in vessels may alter the metabolism, by generating reactive oxygen species (ROS), which might in turn impact the biosafety of Fe-based stents. These considerations emphasize the importance of combining knowledge in both materials and biological science for the development of efficient and safe Fe-based stents, although there are still only limited numbers of reviews regarding this interdisciplinary field. This review aims to provide a concise overview of the main strategies developed so far to design Fe-based stents with accelerated degradation, highlighting the fundamental mechanisms of corrosion and the methods to study them as well as the reported approaches to accelerate the corrosion rates. These approaches will be divided into four main sections, focusing on (i) increased active surface areas, (ii) tailored microstructures, (iii) creation of galvanic reactions (by alloying, ion implantation or surface coating of noble metals) and (iv) decreased local pH induced by degradable surface organic layers. Recent advances in the evaluation of the in vitro biocompatibility of the final materials and ongoing in vivo tests are also provided.
Nanozymes With Osteochondral Regenerative Effects: An Overview of Mechanisms and Recent Applications
Authors: Xueheng Sun, Xiang Xu, Xiaokun Yue, Tianchang Wang, Zhaofei Wang, Changru Zhang, Jinwu Wang
Journal: Advanced Healthcare Materials (2023)

Abstract With the discovery of the intrinsic enzyme‐like activity of metal oxides, nanozymes garner significant attention due to their superior characteristics, such as low cost, high stability, multi‐enzyme activity, and facile preparation. Notably, in the field of biomedicine, nanozymes primarily focus on disease detection, antibacterial properties, antitumor effects, and treatment of inflammatory conditions. However, the potential for application in regenerative medicine, which primarily addresses wound healing, nerve defect repair, bone regeneration, and cardiovascular disease treatment, is garnering interest as well. This review introduces nanozymes as an innovative strategy within the realm of bone regenerative medicine. The primary focus of this approach lies in the facilitation of osteochondral regeneration through the modulation of the pathological microenvironment. The catalytic mechanisms of four types of representative nanozymes are first discussed. The pathological microenvironment inhibiting osteochondral regeneration, followed by summarizing the therapy mechanism of nanozymes to osteochondral regeneration barriers is introduced. Further, the therapeutic potential of nanozymes for bone diseases is included. To improve the therapeutic efficiency of nanozymes and facilitate their clinical translation, future potential applications in osteochondral diseases are also discussed and some significant challenges addressed.
Evaluation of cell membrane-derived nanoparticles as therapeutic carriers for pancreatic ductal adenocarcinoma using an in vitro tumour stroma model
Authors: Christos Tapeinos, Giulia Torrieri, Shiqi Wang, João P. Martins, Hélder A. Santos
Journal: Journal of Controlled Release (2023)

Here, we fabricated nanoparticles made solely from the membrane of cells found in the pancreatic tumour's microenvironment (TME), like the human MiaPaCa-2 cells and M2-polarized macrophages. The cell membrane-derived nanoparticles (CMNPs) deriving from the MiaPaCa-2 cells (MPC2-CMNPs) were loaded with the chemotherapeutic drug paclitaxel (PTX), and the CMNPs deriving from M2-polarized macrophages (M2-CMNPs) were loaded with the colony-stimulating factor 1 receptor inhibitor, pexidartinib (PXDB). The CMNPs' thorough morphological and physicochemical characterisation was followed by an in-depth study of their targeting ability and the endocytosis pathway involved during their internalisation. An in vitro model of the desmoplastic stroma comprising cancer-associated fibroblast-mimicking cells and M2-polarized macrophages was also developed. The model was characterised by collagen and α-smooth muscle actin (α-SMA) expression (overexpressed in desmoplasia) and was used to assess the CMNPs' ability to cross the stroma and target the tumour cells. Moreover, we assessed the effect of PXDB-loaded M2-CMNPs on the expression of M1 (CD80/CD86) and M2 (CD206/CD209) polarisation markers on activated macrophages. Finally, we evaluated the PTX and PXDB-loaded CMNPs' effect on the viability of all the used TME cell lines alone or in combination. Overall, this pilot study showed the potential of the CMNPs to cross an in vitro stroma model and act synergistically to treat PDAC.
Bioinspired fine-tuning of the mechanical rigidity of SNEDDS for the efficient crossing of multiple gastrointestinal barriers
Authors: Jianbo Li, Yaru Xu, Jieke Zhang, Qinglian Li, Chenxu Wang, Zhe Wu, Weijing Yang, Meng Xu, Zhenzhong Zhang, Lei Wang, Jinjie Zhang
Journal: Journal of Controlled Release (2023)
Combining Chitosan, Stearic Acid, and (Cu‐, Zn‐) MOFs to Prepare Robust Superhydrophobic Coatings with Biomedical Multifunctionalities
Authors: Jianwen Zhang, Xinyu Pei, Yihan Liu, Xianlan Ke, Ya Peng, Yajun Weng, Qinyong Zhang, Junying Chen
Journal: Advanced Healthcare Materials (2023)

There is an urgent need to develop a series of multifunctional materials with good biocompatibility, high mechanical strength, hemostatic properties, antiadhesion, and anti-infection for applications in wound care. However, successfully developing multifunctional materials is challenging. In this study, two superhydrophobic composite coatings with good biocompatibility, high mechanical strength, strong antifouling and blood repellency, fast hemostasis, and good antibacterial activity are prepared on cotton fabric surface by simple, green, and low-cost one-step dip-coating technology. The results discussed in the manuscript reveals that the two superhydrophobic composite coatings can maintain good mechanical stability, strong water repellency, and durability under various types of mechanical damage, high-temperature treatment, and long-term strong light irradiation. The coatings also exhibit good repellency to various solid pollutants, highly viscous liquid pollutants, and blood. In vitro and in vivo hemostatic experiments show that both composite coatings have good hemostatic and anticlot adhesion properties. More importantly, this superhydrophobic coating prevents bacterial adhesion and growth and released Cu2+ and Zn2+ ions and chitosan to achieve bactericidal properties, thereby protecting injured skin from bacterial infection. The two superhydrophobic coatings enhance the antifouling, antiadhesion, hemostatic, and antibacterial functions of blood-repellent dressings and therefore have broad application prospects in medical and textile fields.
Biologics (mepolizumab and omalizumab) induced remission in severe asthma patients
Authors: Dennis Thomas, Vanessa M. McDonald, Sean Stevens, Erin S. Harvey, Melissa Baraket, Philip Bardin, Jeffrey J. Bowden, Simon Bowler, Jimmy Chien, Li Ping Chung, Andrew Gillman, Mark Hew, Sandra Hodge, Alan James, Christine Jenkins, Constance H. Katelaris, Gregory P. Katsoulotos, David Langton, Joy Lee, Guy Marks, Matthew Peters, Naghmeh Radhakrishna, Paul N. Reynolds, Janet Rimmer, Pathmanathan Sivakumaran, John W. Upham, Peter Wark, Ian A. Yang, Peter G. Gibson
Journal: Allergy (2023)

Abstract Background Asthma remission has emerged as a potential treatment goal. This study evaluated the effectiveness of two biologics (mepolizumab/omalizumab) in achieving asthma remission. Methods This observational study included 453 severe asthma patients (41% male; mean age ± SD 55.7 ± 14.7 years) from two real‐world drug registries: the Australian Mepolizumab Registry and the Australian Xolair Registry. The composite outcome clinical remission was defined as zero exacerbations and zero oral corticosteroids during the previous 6 months assessed at 12 months and 5‐item Asthma Control Questionnaire (ACQ‐5) ≤1 at 12 months. We also assessed clinical remission plus optimization (post‐bronchodilator FEV1 ≥80%) or stabilization (post‐bronchodilator FEV1 not greater than 5% decline from baseline) of lung function at 12 months. Sensitivity analyses explored various cut‐offs of ACQ‐5/FEV1 scores. The predictors of clinical remission were identified. Results 29.3% (73/249) of AMR and 22.8% (37/162) of AXR cohort met the criteria for clinical remission. When lung function criteria were added, the remission rates were reduced to 25.2% and 19.1%, respectively. Sensitivity analyses identified that the remission rate ranged between 18.1% and 34.9% in the AMR cohort and 10.6% and 27.2% in the AXR cohort. Better lung function, lower body mass index, mild disease and absence of comorbidities such as obesity, depression and osteoporosis predicted the odds of achieving clinical remission. Conclusion Biologic treatment with mepolizumab or omalizumab for severe asthma‐induced asthma remission in a subgroup of patients. Remission on treatment may be an achievable treatment target and future studies should consider remission as an outcome measure.
Dual Key‐Activated Nir‐I/II Fluorescence Probe for Monitoring Photodynamic and Photothermal Synergistic Therapy Efficacy
Authors: Wen‐Xin Wang, Jing‐Jing Chao, Zhi‐Qing Wang, Ting Liu, Guo‐Jiang Mao, Bin Yang, Chun‐Yan Li
Journal: Advanced Healthcare Materials (2023)

As cancer markers, hydrogen peroxide (H2 O2 ) and viscosity play an essential role in the development of tumors. Meanwhile, based on the performance of near-infrared (NIR) fluorescence imaging and the high efficiency of photodynamic therapy (PDT) and photothermal therapy (PTT) synergistic therapy, it is urgent to develop a dual-key (H2 O2 and viscosity) activated fluorescence probe for cancer phototherapy. Herein, a NIR-I/II fluorescence probe named BX-B is reported. In the presence of both H2 O2 and viscosity, the fluorescence signal of NIR-I (810 nm) and NIR-II (945 nm) can be released. In the presence of H2 O2 , the PDT and PTT effects are observed. BX-B is used to monitor its therapeutic effects in cancer cells and tumor-bearing mice due to the increased viscosity caused by PDT and PTT. In addition, the tumors of mice treated with BX-B are almost completely ablated after the laser irradiation based on its PDT and PTT synergistic therapy. This work provides a reliable platform for effective cancer treatment and immediate evaluation of therapeutic effects.
CANT1 lncRNA Triggers Efficient Therapeutic Efficacy by Correcting Aberrant lncing Cascade in Malignant Uveal Melanoma
Authors: Yue Xing, Xuyang Wen, Xia Ding, Jiayan Fan, Peiwei Chai, Renbing Jia, Shengfang Ge, Guanxiang Qian, He Zhang, Xianqun Fan
Journal: Molecular Therapy (2023)

(Molecular Therapy 25, 1209–1221; May 2017) In the originally published version of this article, there were two inadvertent mistakes in Figure 1D lane 5 (top) and Figure 2C lane 2 (top) that were discovered after the authors carefully checked the original data. These two images were mistakenly inserted into Figures 1D and 2C due to carelessness during the uploading of final figures for formal production. The corrected figure panels have been provided below. The authors sincerely apologize for any inconvenience caused to the editors and readers due to these inadvertent mistakes.Figure 2C. Functional Roles of the CANT1 lncRNA in UMView Large Image Figure ViewerDownload Hi-res image Download (PPT) CANT1 lncRNA Triggers Efficient Therapeutic Efficacy by Correcting Aberrant lncing Cascade in Malignant Uveal MelanomaXing et al.Molecular TherapyMarch 9, 2017In BriefXing et al. demonstrate that a novel nuclear CANT1 lncRNA serves as a necessary tumor suppressor in uveal melanoma and delineate a novel lncing cascade in which CANT1 lncRNAs directly build a long non-coding cascade without coding genes, thereby specifying a novel “lncing-cascade renewal” anti-tumor therapeutic strategy by correcting aberrant lncing cascade. Full-Text PDF Open Archive
Combination therapy to overcome ferroptosis resistance by biomimetic self-assembly nano-prodrug
Authors: Yong Huang, Yi Lin, Bowen Li, Fu Zhang, Chenyue Zhan, Xin Xie, Zhuo Yao, Chongzhi Wu, Yuan Ping, Jianliang Shen
Journal: Asian Journal of Pharmaceutical Sciences (2023)

Ferroptosis has emerged as a potent form of no-apoptotic cell death that offers a promising alternative to avoid the chemoresistance of apoptotic pathways and serves as a vulnerability of cancer. Herein, we have constructed a biomimetic self-assembly nano-prodrug system that enables the co-delivery of gefitinib (Gefi), ferrocene (Fc) and dihydroartemisinin (DHA) for the combined therapy of both ferroptosis and apoptosis. In the tumor microenvironment, this nano-prodrug is able to disassemble and trigger drug release under high levels of GSH. Interestingly, the released DHA can downregulate GPX4 level for the enhancement of intracellular ferroptosis from Fc, further executing tumor cell death with concomitant chemotherapy by Gefi. More importantly, this nano-prodrug provides highly homologous targeting ability by coating related cell membranes and exhibits outstanding inhibition of tumor growth and metastasis, as well as no noticeable side-effects during treatments. This simple small molecular self-assembled nano-prodrug provides a new reasonably designed modality for ferroptosis-combined chemotherapy.
Venoarterial extracorporeal membrane oxygenation in patients with infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials
Authors: Uwe Zeymer, Anne Freund, Matthias Hochadel, Petr Ostadal, Jan Belohlavek, Richard Rokyta, Steffen Massberg, Stefan Brunner, Enzo Lüsebrink, Marcus Flather, David Adlam, Kris Bogaerts, Amerjeet Banning, Manel Sabaté, Ibrahim Akin, Alexander Jobs, Steffen Schneider, Steffen Desch, Holger Thiele
Journal: The Lancet (2023)
Antifungal resistance in Candida spp within the intra-abdominal cavity: study of resistance acquisition in patients with serial isolates
Authors: Judith Díaz-García, Marina Machado, Luis Alcalá, Elena Reigadas, Carlos Sánchez-Carrillo, Ana Pérez-Ayala, Elia Gómez-García de la Pedrosa, Fernando González-Romo, Paloma Merino, María Soledad Cuétara, Coral García-Esteban, Inmaculada Quiles-Melero, Nelly Daniela Zurita, María Muñoz-Algarra, María Teresa Durán-Valle, Gabriela Andrea Martínez-Quintero, Aída Sánchez-García, Patricia Muñoz, Pilar Escribano, Jesús Guinea, Judith Díaz-García, Aina Mesquida, Ana Gómez, Marina Machado, Luis Alcalá, Elena Reigadas, Carlos Sánchez-Carrillo, Patricia Muñoz, Pilar Escribano, Jesús Guinea, Ana Pérez-Ayala, Rosaura Pérez Muñoz, María del Carmen Vera González, Elia Gómez-García De La Pedrosa, Fernando González Romo, Paloma Merino-Amador, María Soledad Cuétara, Oscar Manuel Muñoz Clemente, Víctor Antón Berenguer, Aída Sánchez-García, Coral García-Esteban, Oscar Cuevas Lobato, Guadalupe Bernal, Nelly Zurita, Ainhoa Gutiérrez Cobos, María Muñoz-Algarra, Isabel Sánchez Romero, Inmaculada Quiles-Melero, Florinda San Juan Delgado, María Teresa Durán-Valle, Yolanda Gil Romero, Arturo Manuel Fraile Torres, Gabriela Andrea Martínez-Quintero
Journal: Clinical Microbiology and Infection (2023)