tbuckley/cabot-search huggingface dataset:
XPO1-Mediated mRNA Export of Genome Maintenance Regulators Drives Chemotherapy Resistance in Aggressive Lymphoma
Authors: Gero Knittel, Hans Christian Reinhardt
Journal: Cancer Research (2023)

Abstract Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid malignancy and displays vast genetic and transcriptomic heterogeneity. Current treatment guidelines recommend first-line chemoimmunotherapy consisting of an anthracycline backbone, which produces cure rates of approximately 65%. However, the remaining patients will face relapsed or refractory disease, which, even in the era of chimeric antigen receptor T cells, is difficult to treat. In this issue of Cancer Research, Marullo and colleagues investigate the biological underpinnings of the tumor-suppressive activity of the newly approved XPO1 inhibitor selinexor in the treatment of lymphoma. In a translational effort covering genomic and biochemical approaches, combined with in vivo validation experiments and a phase I clinical trial, they demonstrate that upon DNA damage, XPO1 selectively exports transcripts encoding proteins involved in genome maintenance via the RNA-binding proteins THOC4 and eIF4E. Pharmacologic interception of this export process enhances chemosensitivity in various lymphoma models, and combined selinexor plus chemoimmunotherapy displays a favorable toxicity profile and early evidence of efficacy in patients. See related article by Marullo et al., p. 101
Gender Gap in Leadership of Clinical Trials
Authors: Ithai Waldhorn, David Bomze, Irit Ben-Aharon, Shir Schlosser, Gal Markel, Ethan B. Ludmir, Tomer Meirson
Journal: JAMA Internal Medicine (2023)

This cross-sectional study investigates representation of women as principal investigators of clinical trials by study phase, medical specialty, and representation of women trial participants.
Bone Mineral Density in Transgender Adolescents Treated With Puberty Suppression and Subsequent Gender-Affirming Hormones
Authors: Maria Anna Theodora Catharina van der Loos, Mariska Caroline Vlot, Daniel Tatting Klink, Sabine Elisabeth Hannema, Martin den Heijer, Chantal Maria Wiepjes
Journal: JAMA Pediatrics (2023)

Bone mineral density (BMD) z scores in transgender adolescents decrease during puberty suppression with a gonadotropin-releasing hormone (GnRH) agonist. Previous research found that after short-term use of gender-affirming hormones (GAH), pretreatment z scores were not restored. Long-term follow-up studies are lacking.
Maternal and Infant Antibiotic and Acid Suppressant Use and Risk of Eosinophilic Esophagitis
Authors: Elizabeth T. Jensen, Helene M. Svane, Rune Erichsen, Gencer Kurt, Uffe Heide-Jorgensen, Henrik T. Sorensen, Evan S. Dellon
Journal: JAMA Pediatrics (2023)

Eosinophilic esophagitis (EoE), a chronic disease with significant patient and health care burden, has increased rapidly in incidence across many countries. Elucidating risk factors for disease development is a priority for health care practitioners and patients.
Exploratory Tau Biomarker Results From a Multiple Ascending-Dose Study of BIIB080 in Alzheimer Disease
Authors: Amanda L. Edwards, Jessica A. Collins, Candice Junge, Holly Kordasiewicz, Laurence Mignon, Shuang Wu, Yumeng Li, Lin Lin, Jonathan DuBois, R. Matthew Hutchison, Nick Ziogas, Melanie Shulman, Laurent Martarello, Danielle Graham, Roger Lane, Samantha Budd Haeberlein, John Beaver
Journal: JAMA Neurology (2023)

Accumulation of hyperphosphorylated, tangled microtubule-associated protein tau (MAPT) is a pathological hallmark of Alzheimer disease (AD) associated with disease progression and cognitive decline.
Nurse Care Management for Opioid Use Disorder Treatment
Authors: Paige D Wartko, Jennifer F. Bobb, Denise M. Boudreau, Abigail G. Matthews, Jennifer McCormack, Amy K. Lee, Hongxiang Qiu, Onchee Yu, Noorie Hyun, Abisola E. Idu, Cynthia I. Campbell, Andrew J. Saxon, David S. Liu, Andrea Altschuler, Jeffrey H. Samet, Colleen T. Labelle, Mohammad Zare-Mehrjerdi, Angela L. Stotts, Jordan M. Braciszewski, Mark T. Murphy, Douglas Dryden, Julia H. Arnsten, Chinazo O. Cunningham, Viviana E. Horigian, José Szapocznik, Joseph E. Glass, Ryan M. Caldeiro, Rebecca C. Phillips, Mary Shea, Gavin Bart, Robert P. Schwartz, Jennifer McNeely, Jane M. Liebschutz, Judith I. Tsui, Joseph O. Merrill, Gwen T. Lapham, Megan Addis, Katharine A. Bradley, Megan M. Ghiroli, Leah K. Hamilton, Yong Hu, Jennifer S. LaHue, Amy M. Loree, Sean M. Murphy, Thomas F. Northrup, Dikla Shmueli-Blumberg, Angela J. Silva, Zoe M. Weinstein, Mark TinFook Wong, Rachael P. Burganowski
Journal: JAMA Internal Medicine (2023)

Few primary care (PC) practices treat patients with medications for opioid use disorder (OUD) despite availability of effective treatments.
Further Analysis Needed of Migrating Localized ST-Segment Elevation or Was It Lead Reversal?
Authors: Qinghua Chang, Dongdong Wu, Zhaolong Xu
Journal: JAMA Internal Medicine (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Microfluidically Aligned Collagen to Maintain the Phenotype of Tenocytes In Vitro
Authors: Francesca Giacomini, David Baião Barata, Hoon Suk Rho, Zeinab Tahmasebi Birgani, Clemens van Blitterswijk, Stefan Giselbrecht, Roman Truckenmüller, Pamela Habibović
Journal: Advanced Healthcare Materials (2023)

Tendon is a highly organized tissue that transmits forces between muscle and bone. The architecture of the extracellular matrix of tendon, predominantly from collagen type I, is important for maintaining tenocyte phenotype and function. Therefore, in repair and regeneration of damaged and diseased tendon tissue, it is crucial to restore the aligned arrangement of the collagen type I fibers of the original matrix. To this end, a novel, user-friendly microfluidic piggyback platform is developed allowing the controlled patterned formation and alignment of collagen fibers simply on the bottom of culture dishes. Rat tenocytes cultured on the micropatterns of aligned fibrous collagen exhibit a more elongated morphology. The cells also show an increased expression of tenogenic markers at the gene and protein level compared to tenocytes cultured on tissue culture plastic or non-fibrillar collagen coatings. Moreover, using imprinted polystyrene replicas of aligned collagen fibers, this work shows that the fibrillar structure of collagen per se affects the tenocyte morphology, whereas the biochemical nature of collagen plays a prominent role in the expression of tenogenic markers. Beyond the controlled provision of aligned collagen, the microfluidic platform can aid in developing more physiologically relevant in vitro models of tendon and its regeneration.
Projected Change in the Burden of Excess Cardiovascular Deaths Associated With Extreme Heat by Midcentury (2036–2065) in the Contiguous United States
Authors: Sameed Ahmed M. Khatana, Lauren A. Eberly, Ashwin S. Nathan, Peter W. Groeneveld
Journal: Circulation (2023)

Climate change is causing an increase in extreme heat. Individuals with cardiovascular disease are at high risk of heat-related adverse health effects. How the burden of extreme heat-associated cardiovascular deaths in the United States will change with the projected rise in extreme heat is unknown.
Pediatric Hospitalization Trends at Children’s and General Hospitals, 2000-2019
Authors: Michael J. Steiner, Matt Hall, Ashley G. Sutton, John R. Stephens, JoAnna K. Leyenaar, Lindsay Chase, Corrie E. McDaniel
Journal: JAMA (2023)

This study examines whether pediatric inpatient care has been redistributed from general hospitals into children’s hospitals.
Coin-Shaped Opacities in the Stomach
Authors: Neil Shadbeh Evans, Paul Aronowitz, Timothy E. Albertson
Journal: JAMA (2023)

On day 7 after hospital admission, a patient with end-stage kidney disease prescribed sevelamer, hydrocodone-acetaminophen, hydromorphone, and chewable lanthanum tablets developed intermittent apneic episodes, bilateral rhonchi, and responsiveness to verbal commands only with deep painful stimulus; a chest radiograph showed 4 radio-opaque coin-shaped opacities in the stomach. What is the diagnosis and what would you do next?
Our Editorial Fellowship Program: Building Synergism
Authors: Georgina Gyarmati, Alicia A. McDonough
Journal: Journal of the American Society of Nephrology (2023)

Department of Physiology, Keck School of Medicine, University of Southern California, Los Angeles, California Correspondence: Prof. Alicia A. McDonough, Department of Physiology, Keck School of Medicine, University of Southern California, 1975 Zonal Avenue, Los Angeles, CA 90033. Email: [email protected] Published online ahead of print. Publication date available at www.jasn.org.
Advanced Synthetic Scaffolds Based on 1D Inorganic Micro‐/Nanomaterials for Bone Regeneration
Authors: Yonggang Zhang, Yingjie Zhu, Pamela Habibovic, Huanan Wang
Journal: Advanced Healthcare Materials (2023)

Abstract Inorganic nanoparticulate biomaterials, such as calcium phosphate and bioglass particles, with chemical compositions similar to that of the inorganic component of natural bone, and hence having excellent biocompatibility and bioactivity, are widely used for the fabrication of synthetic bone graft substitutes. Growing evidence suggests that structurally anisotropic, or 1D inorganic micro‐/nanobiomaterials are superior to inorganic nanoparticulate biomaterials in the context of mechanical reinforcement and construction of self‐supporting 3D network structures. Therefore, in the past decades, efforts have been devoted to developing advanced synthetic scaffolds for bone regeneration using 1D micro‐/nanobiomaterials as building blocks. These scaffolds feature extraordinary physical and biological properties, such as enhanced mechanical properties, super elasticity, multiscale hierarchical architecture, extracellular matrix‐like fibrous microstructure, and desirable biocompatibility and bioactivity, etc. In this review, an overview of recent progress in the development of advanced scaffolds for bone regeneration is provided based on 1D inorganic micro‐/nanobiomaterials with a focus on their structural design, mechanical properties, and bioactivity. The promising perspectives for future research directions are also highlighted.
Changes in Physician Electronic Health Record Use With the Expansion of Telemedicine
Authors: A. Jay Holmgren, Robert Thombley, Christine A. Sinsky, Julia Adler-Milstein
Journal: JAMA Internal Medicine (2023)

Understanding the drivers of electronic health record (EHR) burden, including EHR time and patient messaging, may directly inform strategies to address physician burnout. Given the COVID-19-induced expansion of telemedicine-now used for a substantial proportion of ambulatory encounters-its association with EHR burden should be evaluated.
Effect of a Social Care Intervention on Health Care Experiences of Caregivers of Hospitalized Children
Authors: Nathaniel J. Glasser, Stacy Tessler Lindau, Kristen Wroblewski, Emily M. Abramsohn, Deborah L. Burnet, Charles M. Fuller, Doriane C. Miller, Christine A. O’Malley, Eva Shiu, Elaine Waxman, Jennifer A. Makelarski, Amy Carter, Christina E. Ciaccio, Emily Chase, Wendy S. Darlington, Katelyn DeAlmeida, Jessica S. Jerome, Jennie Ott, Ritu Verma, Emily Wang
Journal: JAMA Pediatrics (2023)

Health-related social risks (HRSRs), like food and housing insecurity, are stigmatized conditions that, when addressed in clinical settings, could inadvertently compromise health care experiences.
Association Between Slow-Wave Sleep Loss and Incident Dementia
Authors: Jayandra J. Himali, Andree-Ann Baril, Marina G. Cavuoto, Stephanie Yiallourou, Crystal D. Wiedner, Dibya Himali, Charles DeCarli, Susan Redline, Alexa S. Beiser, Sudha Seshadri, Matthew P. Pase
Journal: JAMA Neurology (2023)

Slow-wave sleep (SWS) supports the aging brain in many ways, including facilitating the glymphatic clearance of proteins that aggregate in Alzheimer disease. However, the role of SWS in the development of dementia remains equivocal.
A Glutathione Peroxidase‐Mimicking Nanozyme Precisely Alleviates Reactive Oxygen Species and Promotes Periodontal Bone Regeneration
Authors: Bijun Zhu, Jiangjiexing Wu, Tong Li, Songtao Liu, Junheng Guo, Yijun Yu, Xinyi Qiu, Yue Zhao, Haoran Peng, Jinli Zhang, Leiying Miao, Hui Wei
Journal: Advanced Healthcare Materials (2023)

The use of oxidoreductase nanozymes to regulate reactive oxygen species (ROS) has gradually emerged in periodontology treatments. However, current nanozymes for treating periodontitis eliminate ROS extensively and non-specifically, ignoring the physiological functions of ROS under normal conditions, which may result in uncontrolled side effects. Herein, using the MIL-47(V)-F (MVF) nanozyme, which mimics the function of glutathione peroxidase (GPx), it is proposed that ROS can be properly regulated by specifically eliminating H
Selfie-Induced Diagnostic Challenge in Horner Syndrome
Authors: Luis F. Castro, John A. Butman, Prashant Chittiboina
Journal: JAMA Neurology (2023)

This case report describes an 18-year-old woman with neurofibromatosis type 1 and prior right brachial plexus neurofibroma resection who reported intermittent, unilateral facial flushing after exertion.
Personalized Multilevel Intervention for Improving Appropriate Use of Colorectal Cancer Screening in Older Adults
Authors: Sameer D. Saini, Carmen L. Lewis, Eve A. Kerr, Brian J. Zikmund-Fisher, Sarah T. Hawley, Jane H. Forman, Ann G. Zauber, Iris Lansdorp-Vogelaar, Frank van Hees, Darcy Saffar, Aimee Myers, Lauren E. Gauntlett, Rachel Lipson, H. Myra Kim, Sandeep Vijan
Journal: JAMA Internal Medicine (2023)

Despite guideline recommendations, clinicians do not systematically use prior screening or health history to guide colorectal cancer (CRC) screening decisions in older adults.
Amplifying the Strength and Leadership of Nurses in Opioid Use Disorder Care—Loud and PROUD
Authors: Michael A. Incze, Soraya Azari, Deborah S. Finnell
Journal: JAMA Internal Medicine (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Gender Equity in Clinical Trial Leadership—A Win-Win for Everyone
Authors: Grace Y. Zhang, Ishani Ganguli, Tracy Y. Wang
Journal: JAMA Internal Medicine (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Estimating the effects of preventive and weight-management interventions on the prevalence of childhood obesity in England: a modelling study
Authors: Simon J Russell, Oliver T Mytton, Russell M Viner
Journal: The Lancet Public Health (2023)

The effects of the systematic delivery of treatments for obesity are unknown. We aimed to estimate the potential effects on the prevalence of childhood obesity of systematically offering preventive and treatment interventions to eligible children in England, based on weight or health status.For this modelling study, we developed a cross-sectional simulation model of the child and young adult population in England using data from multiple years of the Health Survey of England conducted between Jan 1, 2010, and Dec 31, 2019. Individuals were assessed for eligibility via age, BMI, and medical complications. Weight status was defined based on clinical criteria used by the UK National Institute of Health and Care Excellence. Published systematic reviews were used to estimate effect sizes for treatments, uptake, and completion for each weight-management tier. We used all available evidence, including evidence from studies that showed an unfavourable effect. We estimated the effects of two systematic approaches: a staged approach, in which children and young people were simultaneously given the most intensive treatment for which they were eligible, and a stepped approach, in which each management tier was applied sequentially, with additive effects. The primary outcomes were estimated prevalence of clinical obesity, defined as a BMI ≥98th centile on the UK90 growth chart, and difference in comparison with the estimated baseline prevalence.18 080 children and young people were included in the analytical sample. Baseline prevalence of clinical obesity was estimated to be 11·2% (95% CI 10·5 to 11·8) for children and young people aged 2-18 years. In modelling, we estimated absolute decreases in the prevalence of obesity of 0·9% (95% CI 0·1 to 1·8) for universal, preventive interventions; 0·2% (0·1 to 0·4) for interventions within a primary-care setting; 1·0% (0·1 to 2·1) for community and lifestyle interventions; 0·2% (0·0 to 0·4) for pharmaceutical interventions; and 0·4% (0·1 to 0·7) for surgical interventions. Staged care was estimated to result in an absolute decrease in the prevalence of obesity of 1·3% (-0·3 to 2·4) and stepped care was estimated to lead to an absolute decrease of 2·4% (0·1 to 4·8).Although individual effect sizes for prevention and treatment interventions were small, when delivered at scale across England, these interventions have the potential to meaningfully contribute to reducing the prevalence of childhood obesity.UK National Institute for Health and Care Research.
Implications of Inflammatory Processes on a Developing Central Nervous System in <scp>Childhood‐Onset</scp> Systemic Lupus Erythematosus
Authors: Hanne van der Heijden, Vanessa Rameh, Emma Golden, Itamar Ronen, Robert P. Sundel, Andrea Knight, Joyce C. Chang, Jaymin Upadhyay
Journal: Arthritis & Rheumatology (2023)

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is increasingly affecting pediatric and adult populations. Neuropsychiatric manifestations (ie, cognitive dysfunction and mood disorders) appear to occur with greater severity and poorer prognosis in childhood-onset SLE (cSLE) versus adult-onset SLE, negatively impacting school function, self-management, and psychosocial health, as well as lifelong health-related quality of life. In this review, we describe pathogenic mechanisms active in cSLE, such as maladaptive inflammatory processes and ischemia, which are hypothesized to underpin central phenotypes in patients with cSLE, and the role of alterations in protective central nervous system (CNS) barriers (ie, the blood-brain barrier) are also discussed. Recent findings derived from novel neuroimaging approaches are highlighted because the methods employed in these studies hold potential for identifying CNS abnormalities that would otherwise remain undetected with conventional multiple resonance imaging studies (eg, T2-weighted or fluid-attenuated inversion recovery sequences). Furthermore, we propose that a more robust presentation of neuropsychiatric symptoms in cSLE is in part due to the harmful impact of a chronic inflammatory insult on a developing CNS. Although the immature status of the CNS may leave patients with cSLE more vulnerable to harboring neuropsychiatric manifestations, the same property may represent a greater urgency to reverse the maladaptive effects associated with a proneuroinflammatory state, provided that effective diagnostic tools and treatment strategies are available. Finally, considering the crosstalk among the CNS and other organ systems affected in cSLE, we postulate that a finer understanding of this interconnectivity and its role in the clinical presentation in cSLE is warranted.
Is it really ever ‘just acne’? Considering the psychodermatology of acne
Authors: Olivia Hughes, Anthony Bewley
Journal: British Journal of Dermatology (2023)

Abstract Acne can create a significant burden for people of all ages. However, the psychological consequences might often be overlooked. This review comments on recent evidence in the field of psychodermatology, to highlight the importance of considering a person's mental health in the treatment of acne. A range of presenting issues are discussed, and cases of underserved patients needing additional considerations are highlighted. This article considers how the psychological sequelae can contribute to the pathogenesis of acne, and discusses how psychotherapeutic approaches can be of benefit to people experiencing appearance-related distress. Importantly, attention is paid to the need for clinicians to assess a patient’s wellbeing alongside their physical symptoms. In doing this, early intervention can be facilitated if psychological comorbidities are present, with referral to appropriate specialist services, where available. To improve treatment outcomes, the skin and the mind must be addressed together in a multidisciplinary approach to dermatology care.