tbuckley/cabot-search huggingface dataset:
AB1751-PARE MUSCULOSKELETAL DISORDERS IN THE ERA OF THE COVID-19 PANDEMIC
Authors: L. Ben Afia, D. Brahim, I. Youssef, Z. Athimni, M. Mersni, N. Mechergui, H. Ben Said, G. Bahri, N. Ladhari
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> In Tunisia, during the last decade, the number of MSDs declared as compensable occupational diseases has been increasing. So, what is the impact of the COVID-19 pandemic on the MSD reporting rate. <h3>Objectives</h3> To describe the socio-professional characteristics of workers with musculoskeletal disorders (MSDs) and to determine the reporting rate of MSDs as occupational diseases. <h3>Methods</h3> A descriptive cross-sectional study among workers with work-related MSDs who consulted the occupational medicine department of the Charles Nicolle Hospital for medical advice between January 2021 and September 2022. <h3>Results</h3> A total of 109 workers with MSDs were included in this study. The workers were 64.2% female. The average age was 46 ± [21-61 years]. The sectors most prone to MSDs were the health sector (27.5%), food processing (16.5%) and textiles (15.6%). The workers reported MSDs of the upper limb in 31.2%, MSDs of the lower limb in 33.9% and of the spine in 69.7%. These MSDs reported included 5/13 cases of rotator cuff tendinopathy, 6/13 cases of carpal tunnel syndrome, one case of achilles tendonitis and one case of Dequervain's tenosynovitis. <h3>Conclusion</h3> During the COVID-19 pandemic, the reporting of MSDs as occupational diseases has declined considerably. This decline can be explained by the difficult access to hospital facilities. <h3>References</h3> [1]https://www.emro.who.int/emhj-volume-23-2017/volume-23-issue-11/prevalence-et-determinants-des-troubles-musculo-squelettiques-des-membres-superieurs-chez-les-artisans-tunisiens.html. [2]http://medecinetravail.canalblog.com/archives/2011/10/04/22196851.html <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1654 IMPACT OF WORK ORGANIZATION ON ROTATOR CUFF TENDINOPATHY
Authors: N. Gannoun, N. Belhaj, M. Lahsisni, O. Dhahri, A. Khedher, A. Omrane, A. Mahfoudh, T. Khalfallah
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Rotator cuff tendinopathy is one of the common causes of shoulder pain. The etiology of rotator cuff tendinopathy has been reported to be multifactorial. Organizational and psychosocial work factors have also been mentioned as important contributors to work-related musculoskeletal disorders. <h3>Objectives</h3> The objective of this study was to assess the impact of work organization on rotator cuff tendinopathy. <h3>Methods</h3> A descriptive cross-sectional study was conducted at the Tahar Sfar Hospital in Mahdia, it concerned patients who consulted the occupational medicine department for shoulder tendinopathies. The information was collected using a self-questionnaire distributed during the medical visit, in order to collect the socio-professional characteristics and organizational constraints. <h3>Results</h3> A total of 100 patients participated in this study. The population was predominantly female (89%). Sixty-five percent of the patients worked in the manufacturing sector and working as a machine operator was the most common occupation (48%). the average job tenure was 22±9 years. The weekly working hours were 45±7 hours on average. All cases had pain in one or both shoulders. On clinical examination, subacromial impingement maneuvers were positive in 94% of the cases and ultrasound revealed rotator cuff tendinopathy in 69% of the cases. In terms of organization, the most common constraints were the need to respect production standards and deadlines (76.9%), to work at a fast pace in 78% of cases, and to carry out their work under continuous supervision (73.4%). On univariate analysis, ultrasound-diagnosed shoulder tendinopathy was significantly associated with female gender (p=0.003), working according to an imposed rhythm (p=0.008), the need to follow directions in order to perform their tasks (p=0.035), and finally, continuous supervision by the work manager (p=0.001). <h3>Conclusion</h3> This study examined factors that were associated with increased risk of rotator cuff tendinopathy. In conclusion, it is essential to identify these factors in order to develop prevention interventions and further high-quality prospective studies are required to identify the exact risk factors for rotator cuff tendinopathy. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1738-PARE RELATIONSHIP BETWEEN DEPRESSION, ANXIETY, AND STIGMATIZATION IN RHEUMATOID ARTHRITIS
Authors: L. Rouached, E. Hannech, S. Bouden, A. Ben Tekaya, I. Mahmoud, R. Tekaya, O. Saidane, L. Abdelmoula
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Depression and anxiety are common comorbidities associated with rheumatoid arthritis (RA). Despite their impact on patients' quality of life, their detection is often neglected. <h3>Objectives</h3> We aimed to assess the anxiety state in patients with RA and to search for associated factors. <h3>Methods</h3> We conducted a cross-sectional study that included patients followed for RA. Patient and disease data were recorded. Patients completed the Hospital Anxiety and Depression Scale (HAD) [1] and the Stigma Scale for Chronic Illnesses-Short Form (SSCI-8) [2] during their day hospital visit or consultation. Disease activity by DAS28-CRP and functional impairment by the HAQ score were calculated. <h3>Results</h3> There were 100 patients. They were mostly women (81%) with a mean age of 55.33±10.08 years [25-76]. Concerning professional status, 61.8% were unemployed, 26.5% were employed, and 11.6% were retired. The mean disease duration was 14.21±10.10 years [1-46]. The mean DAS28-CRP was 3.81±1.56 [0.12-6.90]. The mean HAQ score was 0.91±0.64 [0-2.4]. The mean anxiety score was 7.6±3.2 [1-15]. A definite anxiety state was noted in 21% of patients. The mean depression score was 10.1±3.1 [3-16]. A definite depressive state was noted in 56% of patients. The mean SSCI-8 score was 17.85±6.02 [8-32]. None of the parameters related to the patient, disease activity and functional impairment were correlated with anxiety and depression. The presence of anxiety was influenced by the number of swollen joints (p=0.037). The stigma score was statistically significantly greater in the presence of depression (19.3±6.2 vs 16±5.2, p=0.006). It was also correlated with disease activity (p=0.034, r=0.244). There was no association between stigma scale/HAQ (p=0.754) and stigma scale/anxiety (p=0.137). <h3>Conclusion</h3> According to the results of our study, depression was frequently present in patients followed for RA (56%). Moreover, the stigma is finely related to this comorbidity. This encourages the systematic psychological management of chronic pathologies such as RA. <h3>References</h3> [1]Covic T, Cumming SR, Pallant JF, Manolios N, Emery P, Conaghan PG, Tennant A. Depression and anxiety in patients with rheumatoid arthritis: prevalence rates based on a comparison of the Depression, Anxiety and Stress Scale (DASS) and the hospital, Anxiety and Depression Scale (HADS). BMC Psychiatry. 2012 Jan 24;12:6. [2]Molina Y, Choi SW, Cella D, Rao D. The stigma scale for chronic illnesses 8-item version (SSCI-8): development, validation and use across neurological conditions. Int J Behav Med. 2013 Sep;20(3):450-60. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1653 EPIDEMIOLOGY AND CLINICAL PRESENTATION OF GIANT CELL ARTERITIS IN A REFERRAL HOSPITAL OF NORTHERN SPAIN
Authors: J. Sanchez-Martin, J. Medina-Del Valle, J. Loricera, M. F. Garcia-Reija, R. Blanco
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Traditionally, giant cell arteritis (GCA) was described as a disease of the temporal arteries. It is now accepted that the clinical spectrum has become broader and different diagnostic tools such as PET and US have made possible to diagnose patients who have not been included in the last decades, especially in extracranial forms. Moreover, recently, new diagnosed criteria (2022 ACR/EULAR) have been proposed. This implies an evident change of the clinical epidemiology of GCA. <h3>Objectives</h3> To assess the clinical epidemiology of GCA accordingly to new diagnostic tools and 2022 ACR/EULAR criteria. <h3>Methods</h3> Observational study of patients diagnosed with GCA who underwent temporal artery biopsy (TAB) between January 2016 and December,2022. The patients were divided into 3 groups: <b>a</b>) only cranial (cGCA), <b>b</b>) only extracranial (ecGCA), and <b>c</b>) mixed affection (mixGCA). The diagnosis of GCA was made according to <b>a</b>) temporal artery biopsy, and/or <b>b</b>) EULAR/ACR2022 criteria, and/or <b>c</b>) imaging techniques. Demographic, clinical, analytical and imaging techniques characteristics were studied. <h3>Results</h3> We included 191 patients (120 females/71 males), with a mean±SD age of 74.9±9.6 years. The main characteristics of the patients and the differences among phenotypes are shown in <b>Table 1</b>. Only a 27.2% of the patients had a positive TAB with a mean±SD length of 16.4±6.3mm. The GCA phenotype most frequent was the cranial GCA (cGCA). Headache (79.6%) was the most common ischemic manifestations, followed by the abnormal examination of temporal artery (46.6%) and visual symptoms (including 8.4% patients with blindness), jaw or lingual claudication (26.3%), and scalp tenderness (25.1%). Polymyalgia rheumatica (PmR) was the most frequent systemic manifestations, observing in 59.2% of the patients. The values of serum CRP and ESR are shown in <b>Table 1</b>. <h3>Conclusion</h3> GCA is a vasculitis which has increased its clinical spectrum with extracranial involvement, affecting people with a mean age of more than 70 years and with a female predilection. PmR appears to be present in more than half of the patients, mainly in extracranial phenotype. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1757-PARE PATIENTS WITH SPONDYLOARTHRITIS SUFFER IN SILENCE: THE IMPACT OF THE DISEASE ON THEIR QUALITY OF LIFE
Authors: E. Hannech, S. Boussaid, S. Rekik, S. Rahmouni, K. Zouaoui, H. Ajlani, H. Sahli, M. Elleuch
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Spondyloarthritis (SpA) is a chronic disease that often causes functional impairment, resulting in a negative impact on patients' quality of life (QoL). <h3>Objectives</h3> We aimed to assess QoL of patients with SpA using a validating tool. <h3>Methods</h3> We conducted a cross-sectional study including patients with SpA. Sociodemographic, clinical, and therapeutic data were collected. Patients' QoL was assessed using the validated Tunisian version of the EQ-D5 questionnaire, which is a standardized measuring instrument that assesses the state of health according to five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. The answers were converted into EQ-5D index. <h3>Results</h3> There were 100 SpA patients with a mean age of 43.68±10.3 years [20-76]. Regarding mobility, 2 patients reported extreme problems, 61 patients had some problems, and 37 patients had no problems. Six patients were totally non-autonomous, 55 were partially autonomous, and 39 patients had no problems in the self-care domain. Thirty-five patients had no problems in their usual activities, 60 patients had some problems, and 5 patients had extreme problems. Twenty-six patients had significant pain or discomfort at the time of the study, 61 patients had moderate pain or discomfort, and 13 patients had no pain. A significant level of anxiety/depression was observed in 12 patients, 46 patients had moderate depression or anxiety, and 42 patients had no psychological problems. The global VAS of health status had a mean value of 59± 25% [7-100]. The mean EQ-5D index was 0.485±0.378 [-0.448-1]. In 12 cases the index was negative, defining an extremely large effect of the disease on QoL, while 7 patients had an index equal to 1, showing that the disease had no effect on their QoL. <h3>Conclusion</h3> Despite therapeutic advances, patients with SpA still suffer in their daily living. So, an early and appropriate management is necessary. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1857 A FIRST CASE REPORT OF SCHNITZLER SYNDROME PRESENTING WITH ACROPACHY AND LITERATURE REVIEW
Authors: X. Sun, Z. Zhang
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Schnitzler syndrome (SchS) is a rare and easily misdiagnosed autoinflammatory disease. The misdiagnosis not only delays proper treatment, but also leads to the unreasonable use of immunosuppressants or even chemotherapeutic agents which results in needless financial and physical burdens. <h3>Objectives</h3> The objective of this study was to summarize the clinical features and help physicians to avoid more misdiagnosis. <h3>Methods</h3> Here we report a 52-year-old female with SchS, who suffered from chronic pruritic urticaria, fever, and arthralgia for over 10 years. Then we systemically reviewed 471 patients, 470 from 138 previous case reports and 1 from our case report. <h3>Results</h3> Most of the patients were middle-aged or elderly women from European and American countries. There were limited number of cases coming from Asia, and no cases from Africa had yet been identified. The main clinical manifestations included chronic urticaria with or without pruritus, fever, arthralgia, ostealgia/myalgia, fatigue, and weight loss. Some cases also presented with lymphadenopathy, hepatomegaly, and splenomegaly. The presence of monoclonal immunoglobulin was the main diagnostic criteria, and the most common was IgMκ. Laboratory examinations also showed elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). Neutrophil infiltration was the most common pathological results in the skin tissue of SchS patients. Currently, anti-IL-1 therapy seems to be the best choice, followed by anti-IL-6 therapy. Glucocorticoid and traditional immunosuppressants seemed to be ineffective to SchS. <h3>Conclusion</h3> As the diversity and variability of clinical symptoms, clinicians should pay more attention to the features of SchS to avoid misdiagnosis. Nearly half a century has passed since the first case of SchS was reported. Exploring its pathogenesis is still on the way. More Research is warranted for individualized therapy. <h3>References</h3> [1] H.D. de Koning, Schnitzler's syndrome: lessons from 281 cases. Clinical and translational allergy 4 (2014) 41. [2] H. Uda, and O. Saiki, Appearance of non-rheumatoid arthralgia after tocilizumab treatment in patients with rheumatoid arthritis. Scandinavian journal of rheumatology 42 (2013) 247-8. [3] K. Krause, A. Tsianakas, N. Wagner, J. Fischer, K. Weller, M. Metz, M.K. Church, and M. Maurer, Efficacy and safety of canakinumab in Schnitzler syndrome: A multicenter randomized placebo-controlled study. The Journal of allergy and clinical immunology 139 (2017) 1311-1320. [4] A Betrains, F Staels, and S Vanderschueren. Efficacy and safety of canakinumab treatment in schnitzler syndrome: A systematic literature review. Semin Arthritis Rheum. 2020 Aug;50(4):636-642. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1741-PARE THE IMPACT OF THE DISEASE’S ANNOUNCEMENT ON RHEUMATOID ARTHRITIS PATIENTS
Authors: E. Rabhi, K. Maatallah, H. Ferjani, D. Ben Nessib, D. Kaffel, W. Hamdi
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Rheumatoid arthritis is a chronic disease that can cause irreversible joint damage and significant disability [1]. The announcement of this diagnosis remains one of the most unpleasant moments in the medical practice for both patients and caregivers. For the physician, whose primary mission is to provide relief, knowing that it may cause psychological distress is a challenging task. <h3>Objectives</h3> We aimed to study the impact of the disease’s announcement on rheumatoid arthritis patients. <h3>Methods</h3> We conducted a cross-sectional study including patients fulfilling the American Congress Of Rheumatology/ European League Against Rheumatism (ACR EULAR) 2010 criteria. We collected epidemiological, clinical, biological (C-reactive protein: CRP, erythrocyte sedimentation rate (ESR), immunological status (rheumatoid factor RF and anti-citrullinated protein/peptide antibody ACPA), disease activity index (The Disease Activity Score 28 DAS 28). Patient’s experience during the announcement of diagnosis was assessed using a questionnaire. <h3>Results</h3> Thirty patients were enrolled. There were 25 women and five men. The mean age was 67.10 ± [29-75]. The mean duration of the disease was 10.41 ± [2.5- 38] years. The mean DAS 28 VS was 4.5 ± [1.36-6.27]. Among 30 patients, 66.67 % received the news with anxiety, particularly because of the chronic nature of the disease and possible multi-organ involvement. Nine patients were reassured and felt less anxious for having understood the cause of their pain. Seventy patients (56.67 %) found that the doctor was empathetic and tried to explain the therapeutic alternatives reducing their stress. However, 30% of patients (n=9) found the announcement shocking and would have preferred a gradual approach. <h3>Conclusion</h3> Our study showed stress and anxiety are common feelings for most patients, highlighting the importance of a patient-centered approach to improve initial acceptability of. their disease. <h3>Reference</h3> [1]Grajales H. [The announcement of a diagnosis in psychiatry]. Rev Infirm. mai 2022;71(281):49‑50. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1739-PARE COVID-19 PANDEMIC: THE IMPACT ON PSORIATIC DISEASE PATIENTS’ LIFE
Authors: U. Viora, G. Mascarino, D. Rava, D. Romagnolo, M. T. Mascarino
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> In last years, "psoriatic disease" identifies a complex pathology, characterized by the involvement not only of the joints but also of other organs and systems such as skin, eyes, bowl, cardiovascular system. About 30% of patients with psoriasis may manifest involvement of the musculoskeletal system, involving joints in its various anatomical components and enthesis. Psoriatic arthritis and psoriasis have certainly been – during the pandemic - among the most neglected pathologies from the care perspective. <h3>Objectives</h3> AMaR Piemonte (Rheumatic Patients Association of Piedmont) and ANAP (National Association "Friends for the skin") due to the number of phone calls received during the first stages of pandemic and interacting with rheumatologists, dermatologists and psychologists made a specific survey to assess the impact of the pandemic both on people suffering from psoriatic disease and by their caregivers. In this abstract we focus our attention to the "caregivers world". <h3>Methods</h3> A specific questionnaire for caregivers, developed by a dermatologist and a psychologist and aimed to assess the experience during the pandemic (feelings, changes in care, interpersonal relationships, possible recourse to the intake of "comfort goods" such as smoking, alcohol, food, substances, etc.) was administered in parallel with that for patients online on the websites and social media of the two associations from mid-October to mid-December 2020 and from mid-January to mid-March 2021. <h3>Results</h3> 251 were the complete answers, mainly (84%) provided women who cared for family members (75%) suffering from Psoriatic Arthritis (37%). The average age was 46 years and people reported dealing with people with moderate (46%) or severe (41%) disease, whose symptoms worsened in 69% Impotence, anxiety, stress, sadness and frustration are the emotions most often reported by the caregiver who, moreover, believes they are also experienced by the assisted person. The assistance is worsened in 59% of cases, especially due to the inability to contact the doctor (16%) and undergo examinations/ checks (35%). <h3>Conclusion</h3> The COVID-19 pandemic has deeply changed the life of caregivers, mainly women of working age and patient's relatives or partners. Caregivers and patients, however, developed a full agreement, manifesting the same emotions and resorting to refuge substances in overlapping percentages. The need not to suffer interruptions or changes in care by the attending physician is felt with greater intensity by caregivers, perhaps due to they have no specific preparation to assist their loved ones. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1684 DIFFERENCES BETWEEN DISEASE ACTIVITY MEASURED BY ULTRASOUND VERSUS THE STANDARDIZED CLINICAL ACTIVITY INDEX (DAS28 AND DAPSA) FOR RHEUMATOID ARTHRITIS AND PSORIATIC ARTHRITIS BEFORE STARTING BIOLOGICAL THERAPY: A RETROSPECTIVE STUDY
Authors: I. M. Fernández-Maeztu Palacín, D. Ruiz-Montesinos, P. Muñoz Reinoso, A. Fernández Reboul Fernández, J. Rodas, J. J. Pérez Venegas
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Numerous studies have been written about the role of ultrasound as an objective tool for measuring damage and to predict subsequent progression of inflammatory joint diseases, as well as to detect low-grade synovitis, even in patients with low disease activity.<sup>[1]</sup> It has been suggested that some patients with subclinical inflammation may experience radiological progression and joint damage despite being in clinical remission.<sup>[2]</sup> <h3>Objectives</h3> The main objective of this study is to analyze the differences between the disease activity measured by ultrasound versus the standardized clinical activity index (DAS28 and DAPSA) for Rheumatoid Arthritis (RA) and Psoriatic Arthritis (APS) before the start date treatment with biological therapies. <h3>Methods</h3> A retrospective, non-interventional study was performed by reviewing the databases of RA and APS patients from the Hospital Universitario Virgen Macarena's Rheumatology department as well as an inferential study comparing the disease activity measure by ultrasound to the standardized clinical activity index. <h3>Results</h3> 85 ultrasounds of patients with RA (N=54) and APS (N=31) have been included and correlated with the baseline ultrasound activity before the start date treatment with biological therapies. The contrast of the baseline DAS28 and DAPSA means for the different ultrasound findings did not show significant differences (Table 1). <h3>Conclusion</h3> In our daily clinical practice, an adequate correlation is found between the finding data. However, approximately 24% of patients with moderate/high clinical activity by DAS28/DAPSA had no ultrasound activity. While the results are not statistically significant, this fact can be explained by the small sample size limitation. More studies are needed to make recommendations about the role of ultrasound (in conjunction with the standardized activity index) to ensure the proper therapeutic strategies in inflammatory joint diseases. <h3>References</h3> [1]Cruces M, Al Snih S, Serra-Bonett N, Rivas JC. Subclinical synovitis measured by ultrasound in rheumatoid arthritis patients with clinical remission induced by synthetic and biological modifying disease drugs. Reumatol Clín (Engl Ed) [Internet]. 2019 [citado el 4 de febrero de 2022];15(4):218–22. [2]Gärtner M, Mandl P, Radner H, Supp G, Machold KP, Aletaha D, et al. Sonographic joint assessment in rheumatoid arthritis: associations with clinical joint assessment during a state of remission: Sonographic versus clinical joint assessment in RA. Arthritis Rheum [Internet]. 2013;65(8):2005–14. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.