AB1545-HPR MALNUTRITION IN PATIENTS WITH RHEUMATOID ARTHRITIS OVER 65 YEARS OF AGE
Authors: L. Cano Garcia, D. Ruiz, P. Armenteros, C. Dominguez, N. Al Mashhadani, N. Mena-Vázquez
Journal: Annals of the Rheumatic Diseases (2022)

Background Malnutrition is one of the most important geriatric syndrome and fragility factor in older people. In adittion to being a disease sign, its presence is related with increasing of morbility, longer hospitalizations, institucionalization and mortality due to concomitant diseases. Objectives Describe prevalence of malnutrition risk and associated factor in patients with rheumatoid arthritis (RA) over 65 years of age. Methods Design: A case-controls study. Participants: Cases: Recruitment was performed by random sampling between patients over 65 years of age with RA (ACR/EULAR 2010 criteria) attended at 4 Spanish University Hospitals. Controls: Recruitment of subjects without rheumatoid disease was performed asking for case patients who attended to medical center with a similar-age (age of range +/- 5 years) and same-gender person from same social or family environment. Variables y measures: The main variable was malnutrition risk, measured by screening of Mini Nutritional Assessment. Other variables were: presence of sarcopenia, defined according to European Working Group on Sarcopenia in Older People (EWGSOP) 2019, economic status, dual-energy x-ray absorptiometry (DEXA) in spine and hip to osteoporose screening, toxic habits, comorbidities and Charlson index, physical activity measured with Global physical activity questionnaire (GPAQ) and Short Physical Performance Battery (SPPB), haemoglobin, calcium, D and B12 vitamins, total proteins, albumin, C reactive protein, body mass index (BMI), polimedication, quality of life measured with EQ-5D and RA related factors, activity disease measured with DAS28, SDAI and CDAI; physical function measured with HAQ (Health assessment questionnaire) and global functional status according ACR criteria. Statistical analysis: Descriptive and multivariative analysis was performed to identify factors associated to sarcopenia in RA. Results 152 subjects were included in the study, 76 RA and 76 controls.More patients than controls with malnutrition risk were found, although there were no significative difference (24 [31,6%] vs 17 [22,4%]; p=0,136). More women with RA were included (78,9%), with media ± SD of age 74,7 ± 3,78., sarcopenia was presented in 9/24 (37,5%) and Charlson index was 3 points in 11/24 patients (45,8%) and 4 points in 8/24 patients (33,3%). According to the treatment, almost a 40%, no DMARDs were taken and neither 25% biological DMARD. 58,3 % of patients received corticosteroids and mayority of them (95,8%) were polimedicated. RA patients who presented desnutrition risk, in comparison with the rest of patients, had a media of upper age (p=0,007), more frequency of sarcopenia (p=0,006), right tricipital skinfold thickness (p=0,043). Also, higher values were found in activity index like physical function and quality of life: DAS28 (p=0,003), HAQ (p=0,044), Vitamin D (p=0,035), IPAQ (p=0,003), SPPB (p=0,018), EQ5D (p=0,01), VAS EQ5D (p=0,044), SDAI (p= 0,006), CDAI (p=0,008). In multivariative análisis, factors associated by independent way to malnutrition risk were age (OR [CI 95%], 1,148 [1,020-1,291]; p=0,022) and inflammatory disease by DAS28 (OR [CI 95%], 2,043 [1,198-3,483]; p=0,009) (R2=0,252). Conclusion Even though frequency of malnutrition was similar in cases and controls, in RA was associated with inflammatory activity and older age. It´s important monitoring malnutrition risk in this kind of patients to perform correct interventions to prevent and improve nutrition. Disclosure of Interests None declared