tbuckley/cabot-search huggingface dataset:
Re: Simpa S. Salami, Jeffrey J. Tosoian, Srinivas Nallandhighal, et al. Serial Molecular Profiling of Low-grade Prostate Cancer to Assess Tumor Upgrading: A Longitudinal Cohort Study. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.06.041
Authors: Clement Orczyk, Teresa Marsden, Mark Emberton
Journal: European Urology (2020)
Ventricular fibrillation associated with use of electrocautery. A case report
Authors: R. F. Hungerbuhler
Journal: JAMA (1974)

WITH the introduction of many electrical instruments into the operating room, there are increased hazards.<sup>1</sup>The electrocautery has decreased operating time and blood loss, but in conjunction with monitoring equipment has caused burns. The purpose of this report is to describe a case of ventricular fibrillation that occurred during use of the electrosurgical unit in a patient being monitored by many instruments. We are unaware of a previous report of ventricular fibrillation associated with use of the electrosurgical unit. <h3>Report of a Case</h3> A 24-year-old woman was scheduled for elective surgical correction of an asymptomatic secundum-type atrial septal defect. Cardiac catheterization three days before operation was uneventful and demonstrated a calculated 4.2:1 left to right shunt with right ventricular enlargement and no evidence of pulmonary hypertension. On the morning of surgery, premedication was given intramuscularly: atropine sulfate, 0.6 mg; morphine sulfate, 10 mg; and diazepam, 10 mg, two hours
Hypertension Screening
Authors: Mahendra S. Kochar
Journal: JAMA (1976)

STATISTICS collected by the National Heart and Lung Institute in 1971 indicated that an estimated 23 million Americans have hypertension. Almost half of these were unaware of their condition. Among those aware of their hypertension, half were receiving treatment, and the high blood pressure of only half of these was adequately controlled. In July 1972, then Secretary of Health, Education, and Welfare Elliot L. Richardson launched the National High Blood Pressure Education Program designed to reduce the morbidity and mortality resulting from hypertension by enhancing professional and public awareness. Major reasons for uncontrolled hypertension include the asymptomatic nature of the condition; disagreement among physicians as to what constitutes hypertension; disagreement about the level of blood pressure at which treatment should be started; and unpleasant side effects from medications, decreasing patient compliance. The Landmark Veterans Administration Cooperative studies under the leadership of Edward D. Freis, MD, showed that control of hypertension
THE EFFECTS OF SUBDURAL INJECTIONS OF LEUCOCYTES ON THE DEVELOPMENT AND COURSE OF EXPERIMENTAL TUBERCULOUS MENINGITIS
Authors: Wilfred H. Manwaring
Journal: The Journal of Experimental Medicine (1913)

Rabbit leucocytes, injected into the basal meninges of dogs, in doses from 0.7 to one cubic centimeter apparently invariably cause death. Horse leucocytes, injected in the same amounts, cause death in about 25 per cent. of the dogs. The injection of foreign leucocytes into the meninges of monkeys causes few if any symptoms. The injection of from one to three cubic centimeters of horse leucocytes into the meningeal cavities of dogs, simultaneously with the inoculation of the meninges with tubercle bacilli, causes a slight delay in the development of the paralytic symptoms in about half the treated animals. This delay, however, is very slight when compared with the remarkable prolongation of the latent period previously observed after treatment with dog leucocytes. The injection of foreign leucocytes into the meningeal cavities of monkeys has thus far given almost uniformly negative results. In one small group of monkeys, however, inoculated by the method of lumbar puncture, the injection of rabbit leucocytes has been associated with a prolongation of the latent period in one of the treated monkeys, and with a complete prevention of the subsequent tuberculosis in a second monkey.
REPLY:
Authors: Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee, Christopher F. Rose
Journal: Hepatology (2017)

Potential conflict of interest: Dr. Lee consults for Novartis and Sanofi. He received grants from Gilead, Merck, Ocera, and Exalenz. 1 We thank Fan et al. for their recent interest in our publication on liver‐type fatty acid binding protein (FABP1) in acetaminophen‐induced acute liver failure (APAP‐ALF).1 In this study, we demonstrated that FABP1 may have good potential to discriminate survivors from nonsurvivors and improve models currently used in clinical practice in APAP‐ALF. We concede that one limitation of this study is that we did not have samples or data on critically ill patients with diseases other than ALF. However, this is a common problem in novel ALF biomarker studies.2 Despite the absence of critically ill controls, we believe that massive necrosis of hepatocytes containing overexpressed levels of FABP1 could justify the association with nonspontaneous hepatic recovery and explain the higher FABP1 levels found in nonsurvivors. We speculate that it is unlikely that this would be explained by nonhepatic critical illness alone. Other nonspecific markers of critical illness/sepsis, such as procalcitonin, have performed poorly in ALF studies.3 Finally, in multivariable analysis, we adjusted for other covariates reflecting severity of illness, including shock, and demonstrated that FABP1 was nonetheless independently associated with 21‐day mortality. Regarding Fan et al.'s comments on comparison with commonly used laboratory markers (international normalized ratio [INR] and bilirubin), we have already demonstrated the robustness of FABP1 in parallel with these common biomarkers in the original publication. First, we demonstrated that FABP1 was independently associated with 21‐day mortality adjusting for Model for End‐Stage Liver Disease (MELD; includes INR and bilirubin) at both early and late time points (see Table 3). FABP1 was also shown to have independently improved model performance of currently used prognostic scores, including the King's College Criteria4 and the recently published ALFSG prognostic index5 using the Delong method (Table 4). Both of these prognostic scores include INR and bilirubin. In contrast, total protein and alanine aminotransferase levels have never been demonstrated to be independently associated with mortality in ALF.6 Because FABP1 is excreted to a small degree by the kidney, we adjusted multivariable models for renal function (MELD includes creatinine and recent use of renal replacement therapy). This is shown in Supporting File 4. In summary, in APAP‐ALF we believe that FABP1 yields prognostic information not reflected in current prognostic scores and commonly used blood tests. Nonetheless FABP1 requires validation in studies of ALF patients other than APAP.
THE SLOWNESS WITH WHICH IMPORTANT MEDICAL DISCOVERIES ARE GENERALLY PUT TO PRACTICAL USE.
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
License to plunder or to paint
Authors: G. D. Lundberg
Journal: JAMA (1983)

In an earlier editorial entitled "Rationing Human Life,"<sup>1</sup>we pointed out that many factors complicate judgments about the dispersal of funds from the public wealth for individual patients given heroic treatment to maintain life. We quoted Martin Luther King when he said that quality of life was more important than quantity. We stated that no one had determined how much one human life was worth and how society might decide where such enormous outlays of funds would be spent. Furthermore, no one had decided how to go about seeking solutions to these questions. In this issue ofThe Journal, two articles illustrate these dilemmas and seem to demonstrate conflicting positions in programs in which the federal government is involved. The first discusses the substantial number of persons who self-administer psychoactive drugs intravenously, especially heroin, and in whom a chronic inexorable form of kidney disease develops— the so-called heroin-associated nephropathy.
Predictors of employment status after cardiac surgery
Authors: B. A. Stanton
Journal: JAMA (1983)

Preoperative predictors of postoperative employment status were studied in 228 patients (aged 25 to 64 years) who underwent cardiac surgery. Of the 150 patients working in the year before surgery, 73% returned within six months. Of those not so employed, 18% started working. Patients who expected preoperatively to return to work did so at an 82% rate compared with 39% of the others. This was a strong predictor in the multiple regression analysis. Educational level and family income were stronger predictors than occupation or level of physical exertion required. Rates of return were higher in patients with less severe angina and less fatigue preoperatively, but did not differ significantly by sex, surgical procedure, or duration of illness. Seven variables predicted work status correctly for 86% of persons. These results suggest that determinants of return to work are largely present before surgery and that patients' attitudes and expectations play an important role. (<i>JAMA</i>1983;249:907-911)
Erratum: Corrigendum: The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock
Authors: Ezra Aksoy, Salma Taboubi, David Torres, Sandrine Delbauve, Abderrahman Hachani, Maria A Whitehead, Wayne P Pearce, Inma Berenjeno-Martin, Gemma Nock, Alain Filloux, Rudi Beyaert, Veronique Flamand, Bart Vanhaesebroeck
Journal: Nature Immunology (2013)
Inside Cover Image, Volume 39, Issue 6
Authors: Qinghua Wu, Wenda Wu, Bishi Fu, Lei Shi, Xu Wang, Kamil Kuca
Journal: Medicinal Research Reviews (2019)

Description of the Inside front cover image: The cover image is based on the REVIEW ARTICLE JNK signaling in cancer cell survival by Qinghua Wu et al., https://doi.org/10.1002/med.21574. Credit: Cover image © Qinghua Wu and Kamil Kuca Images.
Risque de récidive tumorale après résection endoscopique R1 d’un cancer colo-rectal superficiel
Journal: Endoscopy (2018)

C’est une question qui hante quelquefois nos RCP: quelle prise en charge proposer aux patients présentant un cancer colo-rectal pT1N0M0 de résection endoscopique macroscopiquement complète mais histologiquement R1? Alors que la décision d’une chirurgie complémentaire ne souffre a priori d’aucune ambiguité, cette attitude peut être discutable chez les patients âgés et/ou très comorbides.
Munchausen Syndrome
Authors: S. E. HYLER
Journal: Annals of Internal Medicine (1977)

Comments1 January 1977Munchausen SyndromeS. E. HYLER, M.D.S. E. HYLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-1-121 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I am currently engaged in research on the Munchausen (hospital addiction) syndrome and its variants. I wish to correspond with any other physicians who have had direct contact with such patients. Responses should be addressed to the undersigned.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByP 1 January 1977Volume 86, Issue 1Page: 121-121 Issue Published: 1 January 1977 PDF DownloadLoading ...
Sexual problems are common in general practice patients
Journal: BMJ (2003)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Sexual problems are common in general practice patients Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Renal Transplantation
Authors: Manikkam Suthanthiran, Terry B. Strom
Journal: New England Journal of Medicine (1994)

Renal transplantation is the treatment of choice for patients with end-stage renal disease. Better comprehension of the rejection response, improved preservation of organs, judicious use of cyclosporine, the application of antilymphocyte agents for the prevention and treatment of rejection, and specific protocols for the prevention and treatment of infection have all contributed to the recent improvement in outcome after renal transplantation.Immunobiology of Renal TransplantationThe Anti-Allograft (Rejection) ResponseRenal-allograft rejection depends on the coordinated activation of alloreactive T cells and antigen-presenting cells (e.g., monocyte-macrophages, dendritic cells, and B cells). Whereas acute rejection is a T-cell-dependent process, a broad array . . .
Weeping Higan Cherry Tree, Central Park, New York City
Journal: JAMA Internal Medicine (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Male Hypogonadism
Authors: George P. Chrousos
Journal: Annals of Internal Medicine (2004)

Medical Writings: Book Notes15 June 2004Male HypogonadismGeorge P. Chrousos, MDGeorge P. Chrousos, MDFrom National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-12-200406150-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Winters SJ, ed. 396 pages. Totowa, NJ: Humana; 2004. $135.00. ISBN 1588291316. Order phone 973-256-1699.Field of medicine: Endocrinology.Format: Hardcover book.Audience: Endocrinologists and endocrinology fellows, urologists, obstetrician—gynecologists, and infertility experts. Selected chapters may appeal to internists, primary care physicians, and pediatricians.Purpose: To provide a clinically relevant overview linking basic and clinical research in the male reproductive system and male hypogonadism to patient management.Content: The book is divided into 19 chapters. Chapters 1 through 3 describe the physiology of the male reproductive system, including the neuroendocrine control of the hypothalamic—pituitary—testicular axis, the regulation and functions of the ... Author, Article, and Disclosure InformationAffiliations: From National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 2004Volume 140, Issue 12Page: 1064KeywordsCell physiologyChild healthEndocrinologyGenital anatomyHypogonadismPubertyRenal failureReproductive physiologySoftware toolsTestosterone ePublished: 15 June 2004 Issue Published: 15 June 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
NARCOTIC CONTROL IN GREAT BRITAIN
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Role of Biomethylation in Toxicity and Carcinogenicity of Arsenic: A Research Update
Authors: Miroslav Sty'blo, Zuzana Drobná, Ilona Jaspers, Shan Lin, David J. Thomas
Journal: Environmental Health Perspectives (2002)

Recent research of the metabolism and biological effects of arsenic has profoundly changed our understanding of the role of metabolism in modulation of toxicity and carcinogenicity of this metalloid.Historically, the enzymatic conversion of inorganic arsenic to mono-and dimethylated species has been considered a major mechanism for detoxification of inorganic arsenic.However, compelling experimental evidence obtained from several laboratories suggests that biomethylation, particularly the production of methylated metabolites that contain trivalent arsenic, is a process that activates arsenic as a toxin and a carcinogen.This article summarizes this evidence and provides new data on a) the toxicity of methylated trivalent arsenicals in mammalian cells, b) the effects of methylated trivalent arsenicals on gene transcription, and c) the mechanisms involved in arsenic methylation in animal and human tissues.
Rheumatology
Authors: Daniel J. McCarty
Journal: JAMA (1985)

The recognition of "new" medical syndromes may be important precisely because they are<i>not</i>new. Instead, they permit reclassification of patients heretofore diagnosed as displaying one of the "old" syndromes. Three "new" rheumatologic conditions will be discussed briefly. Studies in the United Kingdom have defined a symmetrical polyarthritis of sudden onset and moderate severity associated with parvovirus infection.<sup>1,2</sup>Parvovirus has been identified recently as the etiologic agent of erythema infectiosum (fifth disease). This condition generally occurs in epidemics, affecting infants and children with an evanescent rash that characteristically produces a "slapped face" appearance. The arthritic syndrome is much more common in adults, especially women aged 10 to 58 years (mean, early 30s); an erythematous rash has been present in 30% to 50% of these cases, but rarely resembled a slapped face. Swelling and pain in one or more of the following may occur: small hand joints, wrists, elbows, shoulders,
Spermagglutinating activity and female infertility. A study of serum and genital tract secretions
Authors: J. C. Pacheco-Romero
Journal: JAMA (1973)

Because of reports suggesting that spermagglutinins may be involved in female infertility, we tested serum and genital tract secretions over a three-year period. Initial studies of serums from 42 infertile patients showed a similar frequency of spermagglutinating activity in those with primary infertility (not due to detectable disease) and other forms of infertility. Analysis of serum, uterine, and vaginal secretions from another 31 infertile women showed that spermagglutinating activity was less frequent in the genital tract secretions than in serum. Among the total group of 73 women with various types of infertility, no significant difference in serum spermagglutinating activity was found. Our results do not encourage belief that spermagglutinating activity plays an important role in female infertility.