tbuckley/cabot-search huggingface dataset:
Roadmap to VIRTUAL-GLOBAL: coordinating VItiligo RegisTries for adUlts And chiLdren internationally
Authors: Viktoria Eleftheriadou, Iltefat Hamzavi, Jun Min Bae, Khaled Ezzedine
Journal: British Journal of Dermatology (2023)

Journal Article Roadmap to VIRTUAL-GLOBAL: coordinating VItiligo RegisTries for adUlts And chiLdren internationally Get access Viktoria Eleftheriadou, Viktoria Eleftheriadou Conceptualization, Methodology, Visualization, Writing - original draft, Writing - review & editing Dermatology, New Cross Hospital, Royal Wolverhampton NHS Trust, Wolverhampton, UK Correspondence: Viktoria Eleftheriadou. Email: viktoria.eleftheriadou@nhs.net Search for other works by this author on: Oxford Academic Google Scholar Iltefat Hamzavi, Iltefat Hamzavi Conceptualization, Methodology, Visualization, Writing - original draft, Writing - review & editing Department of Dermatology, Henry Ford Health, Detroit, MI, USA Search for other works by this author on: Oxford Academic Google Scholar Jun Min Bae, Jun Min Bae Conceptualization, Methodology, Visualization, Writing - original draft, Writing - review & editing Department of Dermatology, St. Vincent’s Hospital College of Medicine, The Catholic University of Korea, Korea Search for other works by this author on: Oxford Academic Google Scholar Khaled Ezzedine Khaled Ezzedine Conceptualization, Methodology, Visualization, Writing - original draft, Writing - review & editing Department of Dermatology, Université Paris-Est Créteil Val de Marne, Hôpital Henri Mondor, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 190, Issue 1, January 2024, Pages 114–116, https://doi.org/10.1093/bjd/ljad331 Published: 06 September 2023 Article history Received: 04 August 2023 Revision received: 29 August 2023 Published: 06 September 2023 Accepted: 22 September 2023 Corrected and typeset: 30 September 2023
Neuroprotection by agmatine: Possible involvement of the gut microbiome?
Authors: Priyanka Saha, Subhrajita Panda, Aayusha Holkar, Rahul Vashishth, Sandeep Singh Rana, Mohanapriya Arumugam, Ghulam Md Ashraf, Shafiul Haque, Faraz Ahmad
Journal: Ageing Research Reviews (2023)
p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression
Authors: Gizem Efe, Karen J. Dunbar, Kensuke Sugiura, Katherine Cunningham, Saul Carcamo, Spyros Karaiskos, Qiaosi Tang, Ricardo Cruz-Acuña, Lois Resnick-Silverman, Jessica Peura, Chao Lu, Dan Hasson, Andres J. Klein-Szanto, Alison M. Taylor, James J. Manfredi, Carol Prives, Anil K. Rustgi
Journal: Cancer Discovery (2023)

Abstract TP53 mutations are frequent in esophageal squamous cell carcinoma (ESCC) and other SCCs and are associated with a proclivity for metastasis. Here, we report that colony-stimulating factor-1 (CSF-1) expression is upregulated significantly in a p53-R172H–dependent manner in metastatic lung lesions of ESCC. The p53-R172H–dependent CSF-1 signaling, through its cognate receptor CSF-1R, increases tumor cell invasion and lung metastasis, which in turn is mediated in part through Stat3 phosphorylation and epithelial-to-mesenchymal transition (EMT). In Trp53R172H tumor cells, p53 occupies the Csf-1 promoter. The Csf-1 locus is enriched with histone 3 lysine 27 acetylation (H3K27ac), which is likely permissive for fostering an interaction between bromodomain-containing domain 4 (BRD4) and p53-R172H to regulate Csf-1 transcription. Inhibition of BRD4 not only reduces tumor invasion and lung metastasis but also reduces circulating CSF-1 levels. Overall, our results establish a novel p53-R172H–dependent BRD4–CSF-1 axis that promotes ESCC lung metastasis and suggest avenues for therapeutic strategies for this difficult-to-treat disease. Significance: The invasion–metastasis cascade is a recalcitrant barrier to effective cancer therapy. We establish that the p53-R172H–dependent BRD4-CSF-1 axis is a mediator of prometastatic properties, correlates with patient survival and tumor stages, and its inhibition significantly reduces tumor cell invasion and lung metastasis. This axis can be exploited for therapeutic advantage. This article is featured in Selected Articles from This Issue, p. 2489
Frequency of Screening for Colorectal Cancer by Predicted Life Expectancy Among Adults 76-85 Years
Authors: W. James Deardorff, Kaiwei Lu, Bocheng Jing, Sun Y. Jeon, W. John Boscardin, Kathy Z. Fung, Sei J. Lee
Journal: JAMA (2023)

This study assesses whether colorectal cancer screening varied by predicted life expectancy in a national sample of Veterans Affairs patients aged 76 to 85 years.
Phase I dose escalation and expansion study of golidocitinib, a highly selective JAK1 inhibitor, in relapsed or refractory peripheral T-cell lymphomas
Authors: Y. Song, D.H. Yoon, H. Yang, J. Cao, D. Ji, Y. Koh, H. Jing, H. Eom, J. Kwak, W. Lee, J. Lee, H. Shin, J. Jin, M. Wang, Z. Yang, W.S. Kim, J. Zhu
Journal: Annals of Oncology (2023)
Epidemiological and strain characteristics of invasive meningococcal disease prior to, during and after COVID-19 pandemic restrictions in England
Authors: Stephen A. Clark, Helen Campbell, Sonia Ribeiro, Marta Bertran, Lloyd Walsh, Andrew Walker, Laura Willerton, Aiswarya Lekshmi, Xilian Bai, Jay Lucidarme, Shamez N. Ladhani, Ray Borrow
Journal: Journal of Infection (2023)

In 2020, COVID-19 pandemic restrictions led to a major suppression of meningococcal disease in England. Here we describe the epidemiology of invasive meningococcal disease in the three years prior to the COVID-19 pandemic, and the three years immediately after the introduction of restrictions.
Sustained increase of paediatric invasive Streptococcus pyogenes infections dominated by M1UK and diverse emm12 isolates, Portugal, September 2022 to May 2023
Authors: Catarina Gouveia, Maria Paula Bajanca-Lavado, Rafael Mamede, Ana Araújo Carvalho, Fernanda Rodrigues, José Melo-Cristino, Mario Ramirez, Ana Friães
Journal: Eurosurveillance (2023)

Since autumn 2022, observed numbers of paediatric invasive group A Streptococcus infections in Portugal (n = 89) were higher than in pre-COVID-19 seasons. Between September 2022 and May 2023, the dominant diagnoses were pneumonia (25/79), mostly with empyema (20/25), and sepsis (22/79). A number of cases required admission to intensive care (27/79) and surgery (35/79), and the case fatality rate was 5.1% (4/79). Genomic sequencing (n = 55) revealed multiple genetic lineages, dominated by the M1UK sublineage (26/55) and more diverse emm12 isolates (12/55).
Efficacy and safety of front-line treatment regimens for Waldenstrom macroglobulinaemia: a systematic review and meta-analysis
Authors: Wee-Lee Chan, Vanessa Cui Lian Chong, Ian Jun Yan Wee, Li Mei Poon, Esther Hian Lee Chan, Joanne Lee, Yen-Lin Chee, Anand D. Jeyasekharan, Wee-Joo Chng, Miny Samuel, Sanjay de Mel
Journal: Blood Cancer Journal (2023)

Rituximab-based chemo-immunotherapy is currently the standard first-line treatment for Waldenstrom macroglobulinaemia (WM), while ibrutinib has emerged as an alternative. In the absence of randomised trials (RCTs) comparing these regimens, the optimal first-line treatment for WM remains uncertain. In this systematic review and meta-analysis, we sought to assess the efficacy and safety of first-line treatment regimens for WM. We searched key databases from January 2007 to March 2023, including phase II and III trials, including treatment-naïve WM patients treated with rituximab-based regimens or ibrutinib. Response rates, progression-free survival (PFS), overall survival (OS), and toxicities were evaluated. Four phase III and seven phase II trials were included among 736 unique records. Pooled response rates from all comparative and non-comparative trials were 46%, 33% and 26% for bendamustine rituximab (BR), bortezomib-dexamethasone, cyclophosphamide, rituximab (BDRC) and ibrutinib rituximab (IR), respectively. Two-year pooled PFS was 89%, 81% and 82% with BR, BDRC and IR, respectively. Neuropathy was more frequent with bortezomib, while haematologic and cardiac toxicities were more common with chemo-immunotherapy and ibrutinib-based regimens respectively. Our findings suggest that BR yields higher response rates than bortezomib or ibrutinib-based combinations. RCTs comparing BR against emerging therapies, including novel Bruton Tyrosine Kinase Inhibitors, are warranted.
The clinical significance of Dientamoeba fragilis and Blastocystis in human stool—retrospective cohort study
Authors: David Shasha, Daniel Grupel, Orit Treigerman, George Prajgrod, Yael Paran, Dror Hacham, Ronen Ben-Ami, Dov Albukrek, Galia Zacay
Journal: Clinical Microbiology and Infection (2023)
Development and validation of a novel nomogram to predict postoperative pancreatic fistula after pancreatoduodenectomy using lasso-logistic regression: an international multi-institutional observational study
Authors: Zongting Gu, Yongxing Du, Peng Wang, Xiaohao Zheng, Jin He, Chengfeng Wang, Jianwei Zhang
Journal: International Journal of Surgery (2023)

Background: Existing prediction models for clinically relevant postoperative pancreatic fistula after pancreatoduodenectomy lack discriminatory power or are too complex. This study aimed to develop a simple nomogram that could accurately predict clinically relevant postoperative pancreatic fistula after pancreatoduodenectomy. Methods: A high-volume, multicenter cohort of patients who underwent pancreatoduodenectomy from the American College of Surgeons-National Surgical Quality Improvement Program database in the United States during 2014-2017 was used as the model training cohort (n=3609), and patients who underwent pancreatoduodenectomy from the Pancreatic Center of National Cancer Center Hospital in ***** during 2014-2019 were used as the external validation cohort (n=1347). The study used lasso penalized regression to screen large-scale variables, then logistic regression was performed to screen the variables and build a model. Finally, a prediction nomogram for clinically relevant postoperative pancreatic fistula was established based on the logistic model, and polynomial equations were extracted. The performance of the nomogram was evaluated by receiver operating characteristic curve, calibration curve, and decision curve analysis. Results: In the training and validation cohorts, there were 16.7% (601/3609) and 16.6% (224/1347) of patients who developed clinically relevant postoperative pancreatic fistula, respectively. After screening using Lasso and logistic regression, only 6 predictors were independently associated with clinically relevant postoperative pancreatic fistula, including 2 preoperative indicators (weight and pancreatic duct size), 1 intraoperative indicator (pancreatic texture), and 3 postoperative indicators (deep surgical site infection, delayed gastric emptying, and pathology). The prediction of the new nomogram was accurate, with an area under the curve of 0.855 (95% CI, 0.702-0.853) in the external validation cohort, and the predictive performance was superior to three previously proposed postoperative pancreatic fistula risk score models (all P &lt;0.001, likelihood ratio test). Conclusions: A reliable Lasso-logistic method was applied to establish a novel nomogram based on 6 readily available indicators, achieving a sustained, dynamic, and precise postoperative pancreatic fistula prediction for pancreatoduodenectomy patients. With a limited number of variables and easy clinical application, this new model will enable surgeons to proactively predict, identify and manage pancreatic fistulas to obtain better outcomes from this daunting postoperative complication.
Structural and biological characterization of pAC65, a macrocyclic peptide that blocks PD-L1 with equivalent potency to the FDA-approved antibodies
Authors: Ismael Rodriguez, Justyna Kocik-Krol, Lukasz Skalniak, Bogdan Musielak, Aneta Wisniewska, Agnieszka Ciesiołkiewicz, Łukasz Berlicki, Jacek Plewka, Przemyslaw Grudnik, Malgorzata Stec, Maciej Siedlar, Tad A. Holak, Katarzyna Magiera-Mularz
Journal: Molecular Cancer (2023)

Recent advances in immuno-oncology have opened up new and impressive treatment options for cancer. Notwithstanding, overcoming the limitations of the current FDA-approved therapies with monoclonal antibodies (mAbs) that block the PD-1/PD-L1 pathway continues to lead to the testing of multiple approaches and optimizations. Recently, a series of macrocyclic peptides have been developed that exhibit binding strengths to PD-L1 ranging from sub-micromolar to micromolar. In this study, we present the most potent non-antibody-based PD-1/PD-L1 interaction inhibitor reported to date. The structural and biological characterization of this macrocyclic PD-L1 targeting peptide provides the rationale for inhibition of both PD-1/PD-L1 and CD80/PD-L1 complexes. The IC50 and EC50 values obtained in PD-L1 binding assays indicate that the pAC65 peptide has potency equivalent to the current FDA-approved mAbs and may have similar activity to the BMS986189 peptide, which entered the clinical trial and has favorable safety and pharmacokinetic data. The data presented here delineate the generation of similar peptides with improved biological activities and applications not only in the field of cancer immunotherapy but also in other disorders related to the immune system.
Clinical factors associated with remission of obese acanthosis nigricans after laparoscopic sleeve gastrectomy: a prospective cohort study
Authors: Zhibing Fu, Jinrong Zeng, Liyong Zhu, Guohui Wang, Pengzhou Li, Weizheng Li, Zhi Song, Zhihong Su, Xulong Sun, Haibo Tang, Ping Luo, Lina Tan, Lihua Gao, Dan Wang, Siyu Yan, Lu Zhou, Xiaoliao Tong, Zhen Tang, Hanyi Zhang, Wenbin Tan, Jianyun Lu, Shaihong Zhu
Journal: International Journal of Surgery (2023)

Background: Acanthosis nigricans (AN) involves skin hyperpigmentation in body folds and creases. Obesity-associated AN (OB_AN) is the most common type of AN. The skin condition of obese patients with AN can be improved through bariatric surgery, such as laparoscopic sleeve gastrectomy (LSG), after weight loss. However, the contributing factors to the remission of AN after surgery are still not fully determined. The authors aimed to assess the metabolic and pathological factors associated with remission of AN following LSG in obese individuals. Methods: The study included 319 obese patients who underwent LSG at our hospital. The subjects were divided into obesity (OB) only (OB, n =178) or OB with AN (OB_AN, n =141) groups. The basic clinical and metabolic indices and the dermatological features via reflectance confocal microscopy and histology were collected from patients prior to and after LSG. Results: OB_AN patients had higher fasting plasma glucose, homeostatic model assessment for insulin resistance, and testosterone levels than OB patients. LSG could significantly improve the biochemical and histopathological features of OB_AN patients. The remissive rate of OB_AN patients was about 86.5% (122 out of 141) after surgery. The remission of OB_AN skin lesions was positively correlated with testosterone levels ( P &lt;0.01). In addition, there was a significant positive correlation between changes in AN scores and epidermal thickness and skin pigmentation scores after surgery ( P &lt;0.01). Conclusion: The remissive rate of OB_AN after LSG is associated with improved testosterone levels and reduced epidermal thickness and skin pigmentation levels.
Night shift work, sleep duration and endometrial cancer risk: A pooled analysis from the Epidemiology of Endometrial Cancer Consortium (E2C2)
Authors: Jon Frias-Gomez, Laia Alemany, Yolanda Benavente, Megan A. Clarke, Javier de Francisco, Immaculata De Vivo, Mengmeng Du, Marc T. Goodman, James Lacey, Linda M. Liao, Loren Lipworth, Lingeng Lu, Melissa A. Merritt, Kara A. Michels, Kelli O'Connell, Sonia Paytubi, Beatriz Pelegrina, Paula Peremiquel-Trillas, Stacey Petruzella, Jordi Ponce, Harvey Risch, Veronica Wendy Setiawan, Leo J. Schouten, Xiao-ou Shu, Britton Trabert, Piet A. Van den Brandt, Nicolas Wentzensen, Lynne R. Wilkens, Herbert Yu, Laura Costas
Journal: Sleep Medicine Reviews (2023)
The osteogenic and angiogenic potential of microRNA-26a delivered via a non-viral delivery peptide for bone repair
Authors: Phillip Chambers, Monika Ziminska, Ahmed Elkashif, Jordan Wilson, John Redmond, Antzela Tzagiollari, Cole Ferreira, Auden Balouch, Jasmine Bogle, Seth W. Donahue, Nicholas J. Dunne, Helen O. McCarthy
Journal: Journal of Controlled Release (2023)
Decellularized heart extracellular matrix alleviates activation of hiPSC-derived cardiac fibroblasts
Authors: Charles M. Kerr, Sophia E. Silver, Yi Sun Choi, Martha E. Floy, Amy D. Bradshaw, Seung-Woo Cho, Sean P. Palecek, Ying Mei
Journal: Bioactive Materials (2023)

Human induced pluripotent stem cell derived cardiac fibroblasts (hiPSC-CFs) play a critical role in modeling human cardiovascular diseases
Biomarker Analysis of Vistusertib Plus Paclitaxel Regimen
Authors: Manuel David Gil-Sierra, María del Pilar Briceño-Casado, Cristina Moreno-Ramos
Journal: JAMA Oncology (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
A commentary on ‘Incidence, prevention, risk factors, and prediction of venous thromboembolism in Chinese patients after colorectal cancer surgery: a prospective, multicenter cohort study’
Authors: Yongjing Zhang, Qiuping Li, Hongmei Li
Journal: International Journal of Surgery (2023)

aDepartment of Nursing, Fenyang College of Shanxi Medical University, Shanxi bDepartment of Nursing, School of Medicine of Jiangnan University, Jiangsu, People's Republic of China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address. Department of Nursing, Fenyang College of Shanxi Medical University, Shanxi 032200, People's Republic of China.Tel.:/fax:+139 343 582 10 E-mail: [email protected] (Y. Zhang). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Author correction to “Tumor-microenvironment activated duplex genome-editing nanoprodrug for sensitized near-infrared titania phototherapy” [Acta Pharm Sin B (2022) 4224–4234]
Authors: Zekun Li, Yongchun Pan, Shiyu Du, Yayao Li, Chao Chen, Hongxiu Song, Yueyao Wu, Xiaowei Luan, Qin Xu, Xiaoxiang Guan, Yujun Song, Xin Han
Journal: Acta Pharmaceutica Sinica B (2023)

[This corrects the article DOI: 10.1016/j.apsb.2022.06.016.].
The evolution and heterogeneity of neutrophils in cancers: origins, subsets, functions, orchestrations and clinical applications
Authors: Siyao Liu, Wenchuan Wu, Yueshan Du, Hanlin Yin, Qiangda Chen, Weisheng Yu, Wenquan Wang, Jun Yu, Liang Liu, Wenhui Lou, Ning Pu
Journal: Molecular Cancer (2023)

Abstract Neutrophils, the most prevalent innate immune cells in humans, have garnered significant attention in recent years due to their involvement in cancer progression. This comprehensive review aimed to elucidate the important roles and underlying mechanisms of neutrophils in cancer from the perspective of their whole life cycle, tracking them from development in the bone marrow to circulation and finally to the tumor microenvironment (TME). Based on an understanding of their heterogeneity, we described the relationship between abnormal neutrophils and clinical manifestations in cancer. Specifically, we explored the function, origin, and polarization of neutrophils within the TME. Furthermore, we also undertook an extensive analysis of the intricate relationship between neutrophils and clinical management, including neutrophil-based clinical treatment strategies. In conclusion, we firmly assert that directing future research endeavors towards comprehending the remarkable heterogeneity exhibited by neutrophils is of paramount importance.
Declining access to US maternity care is a systemic injustice
Authors: Katy Backes Kozhimannil
Journal: BMJ (2023)

Access to healthcare is an internationally recognised human right, but the United States is failing at honouring this right for people who are pregnant. 1 Research documenting the scope and consequences of declining access to maternal healthcare, especially in rural areas, has been amassing over the past 10 years. 2 3 News stories have followed, and policy makers have paid attention.In 2018 Congress passed the Improving Access to Maternity Care Act. 4 Yet, despite evidence, media attention, and policy action, the situation isn't getting better.Nowhere to Go: Maternity Care Deserts Across the US, a 2022 report from the non-profit organisation March of Dimes, highlighted ongoing and worsening gaps in access to care during pregnancy, childbirth, and the postpartum period, concentrated in rural and low income communities. 5 For example, the report said that in 2022 more than 2.2 million women of reproductive age lived in counties with no maternity care access, an uptick since the organisation's 2020 report-indicating that 15 933 women lost local maternity care access over those two years.
Dysanapsis as a Determinant of Lung Function in Development and Disease
Authors: Elizabeth A. McGinn, Erica W. Mandell, Bradford J. Smith, Joseph W. Duke, Andrew Bush, Steven H. Abman
Journal: American Journal of Respiratory and Critical Care Medicine (2023)

"Dysanapsis as a Determinant of Lung Function in Development and Disease." American Journal of Respiratory and Critical Care Medicine, 208(9), pp. 956–963
Should I stay or should I go? Spatio-temporal control of cellular anchorage by hematopoietic factors orchestrates tumor metastatic cascade
Authors: Veronica Marabitti, Ignazio Caruana, Francesca Nazio
Journal: Molecular Cancer (2023)

Abstract The term “metastatic cascade” defines a process whereby few tumor cells complete a sequence of steps to leave the primary tumor to reach one or more sites elsewhere in the body, usually through the bloodstream to develop one or several metastases. Due to the nature and plasticity of cancer, unfortunately no specific and functional anti-metastatic drugs are available. In this Commentary, we are highlighting how four essential factors are able to induce adhesion-to-suspension transition (herein referred to as AST) in human cancer cells and how this process may play a key role in tumor metastasis. We further underlined the potential role of hematopoietic transcriptional regulators in reprogramming anchorage dependency of cells, supporting the possible targeting of AST factors as promising therapeutic strategy to overcome metastasis in solid tumor cells.