tbuckley/cabot-search huggingface dataset:
Widespread allele-specific topological domains in the human genome are not confined to imprinted gene clusters
Authors: Stephen Richer, Yuan Tian, Stefan Schoenfelder, Laurence Hurst, Adele Murrell, Giuseppina Pisignano
Journal: Genome biology (2023)

Abstract Background There is widespread interest in the three-dimensional chromatin conformation of the genome and its impact on gene expression. However, these studies frequently do not consider parent-of-origin differences, such as genomic imprinting, which result in monoallelic expression. In addition, genome-wide allele-specific chromatin conformation associations have not been extensively explored. There are few accessible bioinformatic workflows for investigating allelic conformation differences and these require pre-phased haplotypes which are not widely available. Results We developed a bioinformatic pipeline, “HiCFlow,” that performs haplotype assembly and visualization of parental chromatin architecture. We benchmarked the pipeline using prototype haplotype phased Hi-C data from GM12878 cells at three disease-associated imprinted gene clusters. Using Region Capture Hi-C and Hi-C data from human cell lines (1-7HB2, IMR-90, and H1-hESCs), we can robustly identify the known stable allele-specific interactions at the IGF2 - H19 locus. Other imprinted loci ( DLK1 and SNRPN ) are more variable and there is no “canonical imprinted 3D structure,” but we could detect allele-specific differences in A/B compartmentalization. Genome-wide, when topologically associating domains (TADs) are unbiasedly ranked according to their allele-specific contact frequencies, a set of allele-specific TADs could be defined. These occur in genomic regions of high sequence variation. In addition to imprinted genes, allele-specific TADs are also enriched for allele-specific expressed genes. We find loci that have not previously been identified as allele-specific expressed genes such as the bitter taste receptors ( TAS2R s). Conclusions This study highlights the widespread differences in chromatin conformation between heterozygous loci and provides a new framework for understanding allele-specific expressed genes.
Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation
Authors: Ryan M. Boileau, Kevin X. Chen, Robert Blelloch
Journal: Genome biology (2023)

Abstract Background Enhancers are essential in defining cell fates through the control of cell-type-specific gene expression. Enhancer activation is a multi-step process involving chromatin remodelers and histone modifiers including the monomethylation of H3K4 (H3K4me1) by MLL3 (KMT2C) and MLL4 (KMT2D). MLL3/4 are thought to be critical for enhancer activation and cognate gene expression including through the recruitment of acetyltransferases for H3K27. Results Here we test this model by evaluating the impact of MLL3/4 loss on chromatin and transcription during early differentiation of mouse embryonic stem cells. We find that MLL3/4 activity is required at most if not all sites that gain or lose H3K4me1 but is largely dispensable at sites that remain stably methylated during this transition. This requirement extends to H3K27 acetylation (H3K27ac) at most transitional sites. However, many sites gain H3K27ac independent of MLL3/4 or H3K4me1 including enhancers regulating key factors in early differentiation. Furthermore, despite the failure to gain active histone marks at thousands of enhancers, transcriptional activation of nearby genes is largely unaffected, thus uncoupling the regulation of these chromatin events from transcriptional changes during this transition. These data challenge current models of enhancer activation and imply distinct mechanisms between stable and dynamically changing enhancers. Conclusions Collectively, our study highlights gaps in knowledge about the steps and epistatic relationships of enzymes necessary for enhancer activation and cognate gene transcription.
Evidence of Novel Susceptibility Variants for Prostate Cancer and a Multiancestry Polygenic Risk Score Associated with Aggressive Disease in Men of African Ancestry
Authors: Fei Chen, Ravi K. Madduri, Alex A. Rodriguez, Burcu F. Darst, Alisha Chou, Xin Sheng, Anqi Wang, Jiayi Shen, Edward J. Saunders, Suhn K. Rhie, Jeannette T. Bensen, Sue A. Ingles, Rick A. Kittles, Sara S. Strom, Benjamin A. Rybicki, Barbara Nemesure, William B. Isaacs, Janet L. Stanford, Wei Zheng, Maureen Sanderson, Esther M. John, Jong Y. Park, Jianfeng Xu, Ying Wang, Sonja I. Berndt, Chad D. Huff, Edward D. Yeboah, Yao Tettey, Joseph Lachance, Wei Tang, Christopher T. Rentsch, Kelly Cho, Benjamin H. Mcmahon, Richard B. Biritwum, Andrew A. Adjei, Evelyn Tay, Ann Truelove, Shelley Niwa, Thomas A. Sellers, Kosj Yamoah, Adam B. Murphy, Dana C. Crawford, Alpa V. Patel, William S. Bush, Melinda C. Aldrich, Olivier Cussenot, Gyorgy Petrovics, Jennifer Cullen, Christine M. Neslund-Dudas, Mariana C. Stern, Zsofia Kote-Jarai, Koveela Govindasami, Michael B. Cook, Anand P. Chokkalingam, Ann W. Hsing, Phyllis J. Goodman, Thomas J. Hoffmann, Bettina F. Drake, Jennifer J. Hu, Jacob M. Keaton, Jacklyn N. Hellwege, Peter E. Clark, Mohamed Jalloh, Serigne M. Gueye, Lamine Niang, Olufemi Ogunbiyi, Michael O. Idowu, Olufemi Popoola, Akindele O. Adebiyi, Oseremen I. Aisuodionoe-Shadrach, Hafees O. Ajibola, Mustapha A. Jamda, Olabode P. Oluwole, Maxwell Nwegbu, Ben Adusei, Sunny Mante, Afua Darkwa-Abrahams, James E. Mensah, Halimatou Diop, Stephen K. Van Den Eeden, Pascal Blanchet, Jay H. Fowke, Graham Casey, Anselm J. Hennis, Alexander Lubwama, Ian M. Thompson, Robin Leach, Douglas F. Easton, Michael H. Preuss, Ruth J. Loos, Susan M. Gundell, Peggy Wan, James L. Mohler, Elizabeth T. Fontham, Gary J. Smith, Jack A. Taylor, Shiv Srivastava, Rosaline A. Eeles, John D. Carpten, Adam S. Kibel, Luc Multigner, Marie-Élise Parent, Florence Menegaux, Geraldine Cancel-Tassin, Eric A. Klein, Caroline Andrews, Timothy R. Rebbeck, Laurent Brureau, Stefan Ambs, Todd L. Edwards, Stephen Watya, Stephen J. Chanock, John S. Witte, William J. Blot, J. Michael Gaziano, Amy C. Justice, David V. Conti, Christopher A. Haiman
Journal: European Urology (2023)
Profound neutralization evasion and augmented host cell entry are hallmarks of the fast-spreading SARS-CoV-2 lineage XBB.1.5
Authors: Markus Hoffmann, Prerna Arora, Inga Nehlmeier, Amy Kempf, Anne Cossmann, Sebastian R. Schulz, Gema Morillas Ramos, Luis A. Manthey, Hans-Martin Jäck, Georg M. N. Behrens, Stefan Pöhlmann
Journal: Cellular and Molecular Immunology (2023)

Since late 2022, the share of infections caused by the SARS-CoV-2 lineage XBB.1.5has gradually increased in the United States, resulting in XBB.1.5becoming the dominating SARS-CoV-2 lineage in the United States and a similar trend is likely to soon take place also in European countries.However, information on the virological properties of XBB.1.5 is scarce.Here, we conducted an initial virological assessment of the SARS-CoV-2 XBB.1.5lineage.The SARS-CoV-2 XBB lineage possesses an extraordinarily high capacity for antibody evasion due to its unique set of S protein mutations [1][2][3][4].However, this trait may have come at the cost of a moderately reduced host cell entry efficiency as suggested by recent in vitro data [1,5], which may explain why infections caused by XBB sublineages only accounted for a small proportion of total SARS-CoV-2 infections in several countries (except India) so far (Fig. 1a).Recently, this trend has changed for the United States, where the share of infections caused by SARS-CoV-2 sublineage XBB.1.5has gradually increased since late 2022, and XBB.1.5now represents the dominating SARS-CoV-2 lineage (Fig. 1a).Moreover, although being presently detected at low frequencies only, a similar increase in the share of XBB.1.5-relatedinfections is also observed for European countries (Fig. 1a).The XBB.1.5S protein differs by only one mutation (S486P) from the S protein of the parental XBB.1 lineage, and this mutation is located in the receptor-binding domain (RBD) (Fig. 1b).Thus, it may affect transmissibility by modulating cell entry efficiency, and may alter sensitivity to antibody-mediated neutralization.Here, we performed an assessment on the host cell entry efficiency of the SARS-CoV-2 XBB.1.5lineage and its sensitivity to antibody-mediated neutralization, using S protein-bearing pseudovirus particles (pp), which are a suitable model system for the analysis of SARS-CoV-2 host cell entry and its neutralization [6].Particles pseudotyped with the S protein of the ancestral B.1 lineage (B.1 pp ) or Omicron sublineages BA.4/BA.5 (identical on amino acid level, BA.4-5 pp ), BQ.1.1 (BQ.1.1 pp ), or XBB.1 (XBB.1 pp ) were used for comparison.First, we compared cell line tropism and host cell entry efficiency of the different pseudoviruses.As expected, BA.4-5 pp displayed augmented cell entry efficiency compared to B.1 pp for most cell lines tested with the exception
SRTsim: spatial pattern preserving simulations for spatially resolved transcriptomics
Authors: Jiaqiang Zhu, Lulu Shang, Xiang Zhou
Journal: Genome biology (2023)

Spatially resolved transcriptomics (SRT)-specific computational methods are often developed, tested, validated, and evaluated in silico using simulated data. Unfortunately, existing simulated SRT data are often poorly documented, hard to reproduce, or unrealistic. Single-cell simulators are not directly applicable for SRT simulation as they cannot incorporate spatial information. We present SRTsim, an SRT-specific simulator for scalable, reproducible, and realistic SRT simulations. SRTsim not only maintains various expression characteristics of SRT data but also preserves spatial patterns. We illustrate the benefits of SRTsim in benchmarking methods for spatial clustering, spatial expression pattern detection, and cell-cell communication identification.
CTLA-4 blockade induces tumor pyroptosis via CD8+ T cells in head and neck squamous cell carcinoma
Authors: Shuo Wang, Zhi-Zhong Wu, Su-Wen Zhu, Shu-Cheng Wan, Meng-Jie Zhang, Bo-Xin Zhang, Qi-Chao Yang, Yao Xiao, Hao Li, Liang Mao, Zhi-Yong Wang, J. Silvio Gutkind, Zhi-Jun Sun
Journal: Molecular Therapy (2023)
Unmet needs in the study of cellulitis: A response to Salle et al’s “Challenges and limitations of teledermatology for skin and soft-tissue infections: A real-world study of an expert center”
Authors: Matthew A. Gallardo, Allison Yan, Abraham M. Korman, Catherine Chung, Benjamin H. Kaffenberger
Journal: Journal of the American Academy of Dermatology (2023)
TNFα-induced NLRP3 inflammasome mediates adipocyte dysfunction and activates macrophages through adipocyte-derived lipocalin 2
Authors: Hafiz Muhammad Ahmad Javaid, Eun Ko, Esther Jin Joo, Soon Hyo Kwon, Jong-Hwan Park, Sooim Shin, Kae Won Cho, Joo Young Huh
Journal: Metabolism (2023)
Novel agents and regimens in acute myeloid leukemia: latest updates from 2022 ASH Annual Meeting
Authors: Katherine W. DiNardo, Thomas W. LeBlanc, Hui Chen
Journal: Journal of Hematology & Oncology (2023)

Abstract Developments in investigational agents and novel regimens in acute myeloid leukemia (AML) were reported in the 2022 American Society of Hematology (ASH) annual meeting. Encouraging efficacy data were presented from first-in-human studies of two investigational menin inhibitors, SNDX-5613 and KO-539, in relapsed and refractory (R/R) acute myeloid leukemia (AML) with KMT2A rearrangement or mutant NPM1, with overall response rates (ORR) of 53% (32/60) and 40% (8/20), respectively. The addition of the novel drug pivekimab sunirine, a first-in-class antibody–drug conjugate targeting CD123, to azacitidine and venetoclax in R/R AML resulted in an ORR of 45% (41/91), which rose to 53% in those who were venetoclax naïve. Additional novel triplet treatment combinations included the addition of magrolimab, an anti-CD47 antibody, to azacitidine and venetoclax, with an ORR of 81% (35/43) in newly diagnosed AML, including an ORR of 74% (20/27) in TP53 mutated AML. The addition of the FLT3 inhibitor gilteritinib to azacitidine/venetoclax was also featured, with an ORR of 100% (27/27) in newly diagnosed AML and an ORR of 70% (14/20) in R/R AML.
Extracellular vesicles: From bone development to regenerative orthopedics
Authors: Owen G. Davies
Journal: Molecular Therapy (2023)

Regenerative medicine aims to promote the replacement of tissues lost to damage or disease. While positive outcomes have been observed experimentally, challenges remain in their clinical translation. This has led to growing interest in applying extracellular vesicles (EVs) to augment or even replace existing approaches. Through the engineering of culture environments or direct/indirect manipulation of EVs themselves, multiple avenues have emerged to modulate EV production, targeting, and therapeutic potency. Drives to modulate release using material systems or functionalize implants for improved osseointegration have also led to outcomes that could have real-world impact. The purpose of this review is to highlight advantages in applying EVs for the treatment of skeletal defects, outlining the current state of the art in the field and emphasizing avenues for further investigation. Notably, the review identifies inconsistencies in EV nomenclature and outstanding challenges in defining a reproducible therapeutic dose. Challenges also remain in the scalable manufacture of a therapeutically potent and pure EV product, with a need to address scalable cell sources and optimal culture environments. Addressing these issues will be critical if we are to develop regenerative EV therapies that meet the demands of regulators and can be translated from bench to bedside.
UTILITY OF THE HEMOTAG™ DEVICE IN ASSESSING LEFT VENTRICULAR DYSFUNCTION
Authors: Yelenis Seijo De Armas, Antonio Lewis, Dipan Uppal, Mileydis Alonso, Malcolm Lawson McDonald, Alejandro Sanchez, Abdullah Sarkar, Manojna Nimmagadda, Charlene Juan, David A. Baran, Jerry D. Estep, Mauricio Velez, David Snipelisky
Journal: Journal of the American College of Cardiology (2023)
OXIDATIVE STRESS MARKERS AND ANTIOXIDANT ACTIVITY IN PATIENTS WITH IDIOPATHIC COMPLETE HEART BLOCK-UNRAVELING THE MYTH OF CHB ?
Authors: Akshyaya Kumar Pradhan, Shobhit Shah, Rishi Sethi, Sharad Chandra, Gaurav Chaudhary, Monika Bhandari, Akhil Kumar Sharma, Abhishek singh, Ayush Shukla, Sudhanshu K. Dwivedi, Pravesh Vishwakarma, Wahid Ali, Mohammad Kaleem Ahmad
Journal: Journal of the American College of Cardiology (2023)
SODIUM-GLUCOSE COTRANSPORTER-2 INHIBITORS IN HEART FAILURE WITH MILDLY REDUCED OR PRESERVED EJECTION FRACTION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Mahmoud Ismayl, Muhannad Abbasi, Abdullah Al-abcha, Edward El-Am, Andrew Michael Goldsweig, Nandan Sadanand Anavekar
Journal: Journal of the American College of Cardiology (2023)
EFFECT OF RNAI ON CARDIOMYOPATHY AND POLYNEUROPATHY OUTCOMES IN PATIENTS WITH V122I VARIANT HEREDITARY TRANSTHYRETIN-MEDIATED (HATTR OR ATTRV) AMYLOIDOSIS
Authors: Brett Wesley Sperry, Dianna Quan, Elizabeth Mauricio, Roy S. Small, Karthikeyan Ananthasubramaniam, Ugochukwu Onyibo Egolum, Steven Roblin, Elena Yureneva, Lin-Na Chou, Patrick Jay, Kelley Capocelli, Miriam Freimer
Journal: Journal of the American College of Cardiology (2023)
RENAL IMPAIRMENT IMPACTS PRESCRIBING OF NEWER GUIDELINE-DIRECTED MEDICAL THERAPY WELL BEFORE CLINICAL TRIAL DEFINED THRESHOLDS FOR USE
Authors: Trejeeve Martyn, Joshua Saef, Jeremy Brooksbank, Hunter Block-Beach, Max Puthenpura, Jessica Hohman, Nancy M. Albert, Randall C. Starling, Wai Hong Wilson Tang
Journal: Journal of the American College of Cardiology (2023)
THE ROLE OF IMPLANTED CARDIOVERTER DEFIBRILLATOR IN THE ERA OF CONTEMPORARY GUIDELINE-DIRECTED MEDICAL THERAPY FOR HEART FAILURE WITH REDUCED EJECTION FRACTION
Authors: Amro Aglan, Sheila Rajan, Javaria Ahmad, Jui Shah, Guy Kulbak, Sarju Ganatra, Sourbha S. Dani
Journal: Journal of the American College of Cardiology (2023)
DIAGNOSIS-TO-ABLATION TIME AS A PREDICTOR OF RECURRENCE OF ATRIAL FIBRILLATION FOLLOWING CATHETER ABLATION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Hala Najeeb, Syeda Farwa Zaidi, Abdul Moeed, Farah Yasmin, Muhammad Aamir, Muhammad Umair Rana, Yasotha Rajeswaran, Ghulam Akbar, Rahul Gupta, Yasar Sattar, Waqas Ullah, Behzad B. Pavri, Daniel R. Frisch
Journal: Journal of the American College of Cardiology (2023)
THE ROLE OF CD38 AS A THERAPEUTIC TARGET FOR PROTECTION AGAINST DOXORUBICIN-INDUCED CARDIOTOXICITY
Authors: Thais Peclat, Guillermo Agorrody, Julianna D. Zeidler, Claudia Chini, Karina S. Kanamori, Ngan Tran, Laura Colman, Joerg Herrmann, Eduardo Chini
Journal: Journal of the American College of Cardiology (2023)
COMPARISON OF FLUOROSCOPY TIMES AND PROCEDURAL DURATIONS OBTAINED DURING PULMONARY VEIN ISOLATION USING MODERN-GENERATION CRYOBALLOON CATHETERS VERSUS CONTACT FORCE-SENSING RADIOFREQUENCY ABLATION CATHETERS
Authors: Scott W. Simons, Sejal Patel, Joseph E. Parrillo, Simon Gelman, Grant R. Simons
Journal: Journal of the American College of Cardiology (2023)
PROGNOSTIC IMPACT AND INTERACTIONS OF RIGHT VENTRICULAR DYSFUNCTION AND IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS AND/OR CARDIAC RESYNCHRONIZATION THERAPY IN NON-ISCHEMIC CARDIOMYOPATHY: A CARDIAC MAGNETIC RESONANCE STUDY
Authors: Tom Kai Ming Wang, Duygu Kocyigit, Nicholas Chan, Donna Salam, Mustafa Turkmani, Jennifer Bullen, Zoran Popovic, Brian P. Griffin, Christopher Nguyen, Scott D. Flamm, Wai Hong Wilson Tang, Jakub Sroubek, Deborah Kwon
Journal: Journal of the American College of Cardiology (2023)
SINUS BRADYCARDIA IN HOSPITALIZED PATIENTS RECEIVING REMDESIVIR THERAPY FOR COVID-19: A RETROSPECTIVE COHORT STUDY
Authors: Kinjal D. Patel, Dilesha D. Kumanayaka, Krunal Trivedi, Harshvardhan S. Zala, Ahsan Khan, Nirav Patel, Talha Munir, Rime Mehannek, Joaquim Correia
Journal: Journal of the American College of Cardiology (2023)
NEIGHBORHOOD-LEVEL SOCIOECONOMIC STATUS AND PRESCRIPTION FILL PATTERNS FOR GUIDELINE DIRECTED MEDICAL THERAPY AMONG PATIENTS WITH HEART FAILURE
Authors: Amrita Mukhopadhyay, Saul Blecker, Xiyue Li, Ian Matthew Kronish, John A. Dodson, Steven Lawrence, Yaugang Zheng, Sam Kozloff, Rumi Chunara, Samrachana Adhikari
Journal: Journal of the American College of Cardiology (2023)
FRAILTY AND UPTAKE OF ANGIOTENSIN RECEPTOR NEPRILYSIN INHIBITOR FOR HEART FAILURE WITH REDUCED EJECTION FRACTION
Authors: Darae Ko, Yu-Chien Lee, Kueiyu Joshua Lin, Susan Cheng, Elisabetta Patorno, Robert J. Glynn, Theodore Tsacogianis, Dae Hyun Kim
Journal: Journal of the American College of Cardiology (2023)
ANGIOTENSIN RECEPTOR NEPRILYSIN INHIBITION IN ACUTE MYOCARDIAL INFARCTION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Tariq Jamal Siddiqi, Muhammad Shariq Usman, Ahmed Mustafa Rashid, Dayab Asad, Syed Sarmad Javaid, Mahmoud Al Rifai, Javed Butler, Michael E. Hall
Journal: Journal of the American College of Cardiology (2023)
IMPACT OF CAFFEINE LEVELS ON MYOCARDIAL PERFUSION RESERVE INDEX
Authors: Ana Iribarren, Okezi Obrutu, Jenna Maughan, Galen Cook-Wiens, C. Noel Bairey Merz, Debiao Li, Daniel S. Berman, Alan Kwan, Janet Wei
Journal: Journal of the American College of Cardiology (2023)
EFFICACY OF TARGETED NEONATAL ECHOCARDIOGRAPHY IN SCREENING FOR CONGENITAL HEART DISEASE
Authors: Eyad Bitar, Rula Agarushi, Aimann Surak, Dawn Pepper, Matthew Hicks, Abbas Hyderi, Luke Eckersley, Lisa K. Hornberger, Kumar Kumaran
Journal: Journal of the American College of Cardiology (2023)
TAKE CHARGE AT DISCHARGE: THE LACK OF APPROPRIATE DISCHARGE MEDICATIONS IN PATIENTS WHO PRESENTED WITH A ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION WITH NON-OBSTRUCTIVE CORONARY ARTERIES (STE-MINOCA)
Authors: Shreya Makkapati, Morgan A. Venuti, Anika Ross, Oby B. Ibe, Daohai Yu, Xiaoning Lu, Sabrina Islam, Michael P. Gannon
Journal: Journal of the American College of Cardiology (2023)
CORONARY ARTERY BYPASS GRAFTING IN YOUNG PATIENTS - A BRAZILIAN RETROSPECTIVE COHORT STUDY
Authors: Julia De Conti Pelanda, Manuel Felipe De Morais Santos, Tiago Bignoto, Pedro Silvio Farsky, Jorge Farran, Carolina Maldi, Silmara Cristina Friolani, André Souza, Viviane Alves, Vinícius Batista Carlesso, João Italo Dias França, Vivian Lerner Amato
Journal: Journal of the American College of Cardiology (2023)
MORE THAN ONE-FIFTH OF PATIENTS WITH ST-ELEVATION MYOCARDIAL INFARCTION HAVE NORMAL HIGH-SENSITIVITY TROPONIN-T ON PRESENTATION
Authors: Osama Alkhalaila, Alaa Rahhal, Mohammad Altermanini, Khaled Shunnar, Mhd Baraa Habib, Yousef Hailan, Mohammad Alkhateeb, Mohamed Salah Abdelghani, Munsef Barakat, Mohanad Shehadeh, Mohammed Al-Hijji, Abdul Rahman Arabi
Journal: Journal of the American College of Cardiology (2023)
IN HOSPITAL MORTALITY IN PATIENTS PRESENTING WITH ACUTE MYOCARDIAL INFARCTION NEEDING INVASIVE VENTILATION ADMITTED TO MICU VS. CICU
Authors: Sathvik Namburar, Soumya Banna, Christopher Schenck, Andi Shahu, Alexander W. Thomas, Tariq Ali, Christopher F. Barnett, Michael A. Solomon, Paul Elliott Miller
Journal: Journal of the American College of Cardiology (2023)
CLINICAL AND PROGNOSTIC VALUE OF ECHOCARDIOGRAPHY WITH GLOBAL LONGITUDINAL STRAIN IN THE FIRST GENETICALLY MODIFIED PORCINE TO HUMAN CARDIAC XENOTRANSPLANT
Authors: Susie Nam Hong, Manjula Ananthram, Cullen Soares, Susan Joseph, Charles Hong, R. Michael Benitez, Peter Hanna, Corbin E. Goerlich, Timm Dickfeld, Anuj Gupta, Alison Grazioli, Muhammad Mohiuddin, Bartley P. Griffith
Journal: Journal of the American College of Cardiology (2023)
TEMPORAL TRENDS IN THE US OF CARDIAC CT FOR DIAGNOSIS OF LEFT ATRIAL APPENDAGE THROMBUS; THE IMPACT OF COVID-19 PANDEMIC
Authors: Malek Nayfeh, Ahmed Ibrahim Ahmed, Fares Alahdab, Faisal Nabi, Su Min Chang, John J. Mahmarian, Mohammed A. Chamsi-Pasha, Maan Malahfji, Mahmoud Al Rifai, Mouaz H. Al-Mallah
Journal: Journal of the American College of Cardiology (2023)
ROCURONIUM VS SUCCINYLCHOLINE IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION REQUIRING MECHANICAL VENTILATION
Authors: Christopher Schenck, Soumya Banna, Andi Shahu, Alexander W. Thomas, Sathvik Namburar, Cory Heck, Tariq Ali, Paul Elliott Miller
Journal: Journal of the American College of Cardiology (2023)
CAROTID ARTERY PLAQUE ON VASCULAR SCREENING DUPLEX AMONG PATIENTS UNDERGOING CORONARY ARTERY CALCIUM SCORING AS PART OF EXECUTIVE HEALTH MANAGEMENT.
Authors: Adel Hajj Ali, Michael Nakhla, Leslie Cho, Raul John Seballos, Steven Elliot Feinleib, Scott D. Flamm, Paul Schoenhagen, Tom Kai Ming Wang, Milind Y. Desai
Journal: Journal of the American College of Cardiology (2023)
ASSOCIATION OF BASELINE LIPOPROTEIN(A) AND PERCENTAGE OF LIPOPROTEIN(A) LOWERING WITH OLPASIRAN
Authors: Michelle L. O'Donoghue, Robert S. Rosenson, Baris Gencer, J. Antonio, G. Lopez, Norman E. Lepor, Daniel Gaudet, Seth J. Baum, Elmer Stout, Beat Knusel, Julia Kuder, Xinhui Ran, Sabina Murphy, You Wu, Huei Wang, Helina Kassahun, Marc Steven Sabatine
Journal: Journal of the American College of Cardiology (2023)
RISK FACTORS AND THE PROGNOSTIC SIGNIFICANCE OF COVID 19 INDUCED BRADYARRHYTHMIA: A SINGLE CENTER RETROSPECTIVE COHORT ANALYSIS.
Authors: Abdalaziz Awadelkarim, Mohammed Ali, Rashid Alhusain, Ahmed Ahmed, John Dayco, Adnan Halboni, Layla Shanah, Tyler Mumm, M. Chadi Alraies, Nasser M. Lakkis
Journal: Journal of the American College of Cardiology (2023)
MULTINATIONAL PATTERNS OF SECOND-LINE ANTI-HYPERGLYCEMIC DRUG INITIATION IN ESTABLISHED CARDIOVASCULAR DISEASE: A FEDERATED PHARMACOEPIDEMIOLOGIC EVALUATION IN LEGEND-T2DM
Authors: Rohan Khera, Lovedeep Dhingra, Kelly Li, Arya Aminorroaya, Jin Zhou, Faaizah Arshad, Fan Bu, David Dorr, Thomas Falconer, Tina French, Wallis Lau, Yuan Lu, Kenneth Man, Michael Edwin Matheny, Evan Minty, Akihiko Nishimura, Anna Ostropolets, Sarah Seager, Wan Eric Y.F., Jianxiao Yang, Can Yin, George Hripcsak, Harlan M. Krumholz
Journal: Journal of the American College of Cardiology (2023)
APPLICATION OF THE UNIVERSAL DEFINITION OF MYOCARDIAL INFARCTION IN PRACTICE
Authors: Caelan Taggart, Dorothea Kimenai, Erik Kadesjo, Atul Anand, Anda Bularga, Ryan Wereski, Dimitrios Doudesis, Matthew Lowry, Kuan Ken Lee, Andrew R. Chapman, Gustaf Edgren, Andreas Roos, Nicholas L. Mills
Journal: Journal of the American College of Cardiology (2023)