tbuckley/cabot-search huggingface dataset:
The Orphan Drug Act. The first 7 years
Authors: C. H. Asbury
Journal: JAMA (1991)

The 1983 Orphan Drug Act sought to increase market incentives and decrease regulatory barriers for products used to treat rare ("orphan") diseases. Major provisions included market exclusivity, tax credits, and regulatory process clarifications. This analysis compares pre- and post-Act industry and government data to examine changes associated with the law. While industry sponsored 34 marketed and 24 experimental orphan drugs in the 17 years prior to the Act, it has sponsored 39 of 42 marketed orphan products in the 7 years since the Act. An additional 301 experimental products have orphan designation. While 25 of 40 marketed orphan products reportedly had annual sales of less than $1 million, product sales for three conditions are more than $100 million annually. This prompted changes in the law, passed by Congress in 1990, but vetoed. Overall, the law has been associated with an increase in orphan product development. The law's costs and benefits to companies, patients, and the public should be examined if future changes are proposed. (<i>JAMA</i>. 1991;265:893-897)
The Cover
Authors: Frederick Butzen
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3657: Defining the role of the RNA-binding protein MSI2 in neuroblastoma
Authors: Adeiye Pilgrim, Selma Cuya, Dongdong Chen, Robert Schnepp
Journal: Cancer Research (2019)

Abstract Neuroblastoma (NB) is the most common extracranial solid tumor of childhood with a 5-year survival rate approaching 50% in high-risk patients and like other pediatric cancers, lacks many targetable mutations. Thus, novel therapeutic approaches are needed. Previous research has shown that the RNA-binding protein (RBP), LIN28B, enhances MYCN expression and induces NB formation. Additionally, we previously demonstrated that LIN28B-RAN-AURKA signaling drives NB oncogenesis. These results highlight the role of RBPs in modulating NB tumorigenesis. The Musashi family includes RBPs that have been previously shown to be associated with worse prognosis in adult malignancies, including colon cancer and pancreatic cancer, among others. Thus, we speculated that the Musashi family might influence aggressive phenotypes in pediatric tumors, such as neuroblastoma. MSI2 is robustly expressed in neuroblastoma tumors, and, indeed, increased levels of Musashi-2 (MSI2) correlate with worse NB prognosis. In order to begin to elucidate its role in NB tumorigenesis, we knocked-down MSI2 in human NB cell lines using multiple independent short hairpin RNAs (shRNA) and small interfering RNAs (siRNA) and examined the impact on proliferation, survival, and downstream target genes relative to scrambled control RNA-treated cells. From these experiments, we observed decreased colony formation in clonogenic assays, increased apoptosis and decreased proliferation. To gain an initial understanding of the downstream targets that MSI2 influences, we performed Nanostring analysis in 2 human NB cell lines, Kelly and SK-N-DZ and found that knocking down MSI2 led to a downregulation of many cancer-related genes including IDH2 and other metabolic targets. IDH2 is a mitochondrial enzyme and its mutant is known to be involved in gliomagenesis. Changes in IDH2 expression have also been linked to epigenetic alterations. Finally, wild-type IDH2is upregulated in lung cancer and contributes to tumor growth. Therefore, we are currently examining the functional relationship between MSI2 and IDH2 in NB. Citation Format: Adeiye Pilgrim, Selma Cuya, Dongdong Chen, Robert Schnepp. Defining the role of the RNA-binding protein MSI2 in neuroblastoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3657.
Line Dropped
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatitis E Among US Travelers, 1989-1992
Journal: JAMA (1993)

Outbreaks of hepatitis E (i.e., enterically transmitted non-A, non-B hepatitis) have occurred in some parts of the world and have generally been related to contaminated water supplies. Until recently, when research-based serologic tests (1,2) were developed to test for antibody to hepatitis E virus (anti-HEV), no serologic test was available to identify HEV infection, and diagnosis depended on a history of exposure in an appropriate epidemiologic setting and the exclusion of other causes of viral hepatitis. During 1989-1992, acute HEV infection was documented among six persons in the United States who had returned from international travel. This report summarizes CDC's serologic documentation of acute HEV infection--presumed to have been acquired during international travel--in four of these persons.
Twentieth Century Practice. An International Encyclopedia of Modern Medical Science by Leading Authorities of Europe and America
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impact of Initial Body Mass Index (BMI) on Survival Outcome of Patients with Acute Leukemia (AL): Myth or Reality?
Authors: Mael Heiblig, Mohamed Elhamri, Véronique L'Héritier, Hélène Labussière-Wallet, Fiorenza Barraco, Sophie Ducastelle-Leprêtre, Eric Wattel, Mauricette Michallet, Franck E Nicolini, Xavier Thomas
Journal: Blood (2014)
Massachusetts Medical Society
Authors: Murray E. Pendleton, John Figgis Jewett
Journal: New England Journal of Medicine (1960)

COMMITTEE ON MATERNAL WELFAREFetal Death Due to Prothrombin Deficiency, with HemorrhageA twenty-two-year-old colored gravida 2, para 1, had been delivered by cesarean section with her first baby. Previously treated for syphilis, she received 6,000,000 units of penicillin in the fifth month of the present pregnancy because of persistently positive serologic tests. When labor began at thirty-seven weeks a repeat section under inhalation anesthesia produced a male infant weighing 4 kg. (8 pounds, 14 ounces) with enough difficulty to require use of forceps. Positive-pressure resuscitation for four or five minutes was needed but at one hour no abnormalities were . . .
Toxicology
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
International electronic link solves medical puzzle
Authors: P. Gunby
Journal: JAMA (1995)

DIPLOMATS FOSTERING the slow thaw in US-China relations might look to the medical community for inspiration. Via the worldwide computer Internet and other means of communication, physicians and other medical scientists from coast to coast in the United States and at least 17 other countries have helped their mainland China colleagues treat a university student with a challenging array of signs and symptoms. The patient, Zhu Lingling, 21, a junior studying physical chemistry in Beijing, reportedly experienced abdominal pain and alopecia in December 1994 but returned to college in February after she responded to Chinese traditional therapy and nutritional support. A month later, she was hospitalized again with a variety of central nervous system complaints and became comatose within 5 days. After tests ruled out a number of tentative diagnoses and she did not respond significantly to treatment, students at Beijing University who had learned of the complicated case sent
Regional distribution of pulmonary arterial blood flow in emphysema
Authors: V. Lopez-Majano
Journal: JAMA (1966)

Lung scanning after intravenous administration of macroaggregated iodinated I 131 serum albumin has been used to study the regional pulmonary circulation in 62 patients with pulmonary emphysema. The major finding was that 95% of the patients had well-defined areas of decreased pulmonary arterial blood flow. In the majority of the cases, the chest roentgenogram alone was inadequate for demonstrating these localized changes. The scanning method was helpful in differentiating obstructive emphysema from less serious lung disease such as asthma and bronchitis. It was also useful in the determination of the desirability of surgery and in follow-up evaluation.
Corrigendum to: Direct evidence for calcium conductance of hyperpolarization-activated cyclic nucleotide-gated channels and human native If at physiological calcium concentrations
Authors: G. Michels, M. C. Brandt, N. Zagidullin, I. F. Khan, R. Larbig, S. van Aaken, J. Wippermann, U. C. Hoppe
Journal: Cardiovascular Research (2012)
The Question of Asthma and Race
Journal: Environmental Health Perspectives (1997)

me Question of Asthma andw Race In ther 1980s, studis were publishesoi a h between rc and environmental risk, raisin concern that minoritypouainweebignfrl affec b polton.Around thi time, resecs a to notichasthma prevalence was signifcat higher in minority communities.In one 1990 study publish in the Amew s D is hma pre len in bac chiildreni ~was found to~be 7.2%, as compared w'ith3.%amoongwie chdrz A 1994 study publise in P ric nd x h in NewYork WsCit/sminoi Bronx n ooodsa hh as 12.8%.For many the reatonhi between race an stm eemed~toblear evid,~enc
Correction: Treadmill exercise test for predicting coronary disease
Journal: BMJ (1978)

level prevailing in Canada, together with a large capital sum to compensate for the years of underspending in building and equipment.Obviously this is economically not feasible.Though I would welcome in theory a fee- for-service method of remuneration, the problems of its implementation within the NHS are such that each unit of service would be so priced by our political masters that the global remuneration of general practitioners would not increase and the level of bureau- cratic interference and paper work would become extremely onerous.Incidentally, when explaining to Canadian colleagues the method of remuneration of NHS general practitioners they thought that a system combining part capitation, part expense reimbursement, and part fee-for-service was absolutely crazy.But they were extremely envious of our inflationproof pension scheme.
Die Chirurgie:
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABSTRACTS
Journal: Circulation (1951)

Five previous cases of bacterial endocarditis due to Streptobaciltus moniliformis are known and 4 have been reported in the literature.All these cases ended fatally.Three were in the penicillin era, two occurred soon after the use of penicillin but before massive doses of the drug were used.The authors report the following case because it is an apparent cure, and possibly the first one having this infecting organism.The patient, a 40 year old male, had rheumatic fever at age 14 with a recurrence at 16, at which time a heart murmur was noted.He entered many cellars and warehouses infested with rats in his work as a real estate appraiser.He recalled no rat bite or direct contact with a rat or other animal.On June 11, 1948, he first noticed fever; on June 18, a blood culture was taken and he was admitted to the hospital.During his hospital stay eight venous and one arterial blood culture were taken; all were positive for S. moniliftrmis.After sensitivity tests were run penicillin was selected for treatment.This was given over a period of 47 days in dosages increasing from one million to two million units daily.Blood levels rose from one unit per cc. to 8 units per cc. in the final phases of treatment.This treatment resulted in an apparent cure with no recurrence for a month after discharge.
Estrogens and cancer
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thermography of the breast. Current status and future expectations
Authors: H. I. Libshitz
Journal: JAMA (1977)

IN THE early 1970s, clinical thermography of the breast appeared to be a technique that would soon be well established. True-positive rates for carcinoma of the breast were in the area of 70% to 85%. The false-positive rates were in the 15% to 40% range.<sup>1</sup>While it was well recognized that thermography was not a method that could afford a specific diagnosis, it was hoped that an abnormal thermogram could be an adequate prescreener, identifying many breast cancers with a noninvasive, quick, inexpensive technique. Mammography could then be used in this substantially smaller percentage of the population, thereby reducing the radiation exposure to the population at large as well as reducing time and expense in screening women for breast cancer. In an attempt to evaluate this idea, an investigative effort into thermography was included in 27 screening centers established throughout the country in the American Cancer Society—National Cancer Institute
THE TREATMENT OF NEUROSYPHILIS BY MALARIA
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Caution Urged in Exchange Transfusions for Infants
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HYSTERICAL STIGMATIZATION
Authors: JOSEPH E. LIFSCHUTZ
Journal: American Journal of Psychiatry (1957)

The history of stigmatization has fascinated observers from the time of St. Francis of Assisi in the 13th Century to the present. That history is reviewed here. Carefully detailed studies of a modern stigmatized person, Therese Neumann, reveals a seriously disturbed young woman, a severe hysterical personality. One even suspects psychotic disturbances before her stigmatization. Far more rare are reports of non-religious stigmatization. The most striking report is that of William Needles in a case undergoing psychoanalysis. The classical psychodynamic interpretation of hysterical stigmata by Fenichel and Ferenczi is quoted in which they are seen as hysterical "materializations" or "genitalizations." A non-religious stigmatization is reported in this paper, in which the Oedipal conflicts and ambivalences seem to be directly expressed.
Assessment of ventricular rate in patients with chronic atrial fibrillation Kristina Wasmer, Hakan Oral, Christian Sticherling, Steven P. Chough, Robert L. Baker, Hiroshi Tada, Frank Pelosi, Jr., Bradley P. Knight, S. Adam Strickberger, Fred Morady. University of Michigan, Ann Arbor, MI
Journal: Journal of the American College of Cardiology (2001)