tbuckley/cabot-search huggingface dataset:
Hospitalization rates in vasectomized men
Authors: A. M. Walker
Journal: JAMA (1981)

Six thousand ninety-two men who had undergone vasectomy were observed for 20,491 person-years of observation in a prepaid group practice. The incidences of first-time hospitalizations for a variety of diagnoses were examined as a proxy for disease incidence rates and compared with similarly derived rates in the remaining male membership of the practice. Vasectomized men had comparatively high rates of hospitalization for a variety of diseases of the genitourinary system during the early postvasectomy perlod. Apart from these, there were no important, statistically convincing elevations in the new hospitalization rates among vasectomized men, as compared with those of the nonvasectomized comparison group. (<i>JAMA</i>1981;245:2315-2317)
The heartbreak of psoriasis
Authors: R. B. Stoughton
Journal: JAMA (1974)

IT is unfortunate that commercials on radio, television, in newspapers, and elsewhere portray mild scaling of the scalp or skin as "the heartbreak of psoriasis." Many individuals with mild dryness of their skin or ordinary dandruff immediately begin to worry that they may have psoriasis, a fear that may not be dispelled easily. Also, patients with psoriasis eagerly purchase each new product in hope of helping their disease. These advertised formulations are quite bland and<i>have very little, if any, beneficial effect in controlling the lesions of psoriasis.</i> The reasons for these commercials are quite obvious. They are profitable to the manufacturer and the advertising media. However, it is probable that more harm than good comes from this approach to treating patients with psoriasis. Psoriasis is a common but complicated disease that is not amenable to control by over-the-counter or through-the-tube preparations. In fact, detailed regimens worked out on a
BOOK REVIEWS
Authors: A. WESTON
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article BOOK REVIEWS Get access Complex Mixtures and Cancer Risk . H. Vainio M. Sorsa A. J. Mc-Michael , eds. Lyon: IARC , 1990 .x, 441 pp., illus. $95. AlNSLEY WESTON AlNSLEY WESTON Laboratory of Human Carcinogenesis Division of Cancer Etiology National Cancer Institute National Institutes of Health Bldg.37, Rm. 2C09 Bethesda, MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 22, 20 November 1991, Page 1682, https://doi.org/10.1093/jnci/83.22.1682 Published: 20 November 1991
Manuscripts Approved for JNCI, March 1 to April1, 1966
Journal: JNCI Journal of the National Cancer Institute (1966)

Journal Article Manuscripts Approved for JNCI, March 1 to April1, 1966 Get access JNCI: Journal of the National Cancer Institute, Volume 36, Issue 5, May 1966, Page 985, https://doi.org/10.1093/jnci/36.5.985 Published: 01 May 1966
Abstract 13864: Associations Between the Amount and Intensity of Physical Activity and Major Cardiovascular Events in Patients With Stable Coronary Heart Disease: Results From the STABILITY Trial
Authors: Ralph A Stewart, Claes Held, Paul W Armstrong, Christopher P Cannon, Nermin Hadziosmanovic, Emil Hagström, Judith S Hochman, Wolfgang Koenig, Eva Lonn, Jose Nicolau, Philippe Gabriel Steg, David Watson, Lars Wallentin, Harvey D White
Journal: Circulation (2015)

Introduction: Secondary preventive guidelines recommend patients with stable coronary heart disease (CHD) take at least 30 min of moderate or vigorous physical activity (PA) on at least 5 days/week. Hypothesis: Lower levels of PA may be beneficial for cardiovascular (CV) prognosis. Aim: To evaluate associations between self-reported PA, including mild intensity exercise and outcomes in a global cohort of patients with stable CHD. Methods: A lifestyle questionnaire was completed at baseline by 15,486 (97.8%) STABILITY participants. Total PA was estimated from individual subject self-reports of hours spent each week on mild, moderate and vigorous exercise, 2, 4 and 8 METS respectively. Associations between the total amount of PA and MACE (CV mortality, non-fatal myocardial infarction or non-fatal stroke), CV and non-CV mortality were evaluated using Cox proportional hazard models adjusting for age, gender, treatment allocation, markers of disease severity and CV risk factors during a median follow-up of 3.7 yrs. Results: For all subjects, a greater proportion of MET.hours was spent taking mild (50.4%) compared to moderate (39.7%) and vigorous (10.0%) PA. The mean (±SD) PA reported for the ‘sedentary’ (t1, n=5281), ‘mildly active’ (t2, n=5055) and ‘moderately active’ (t3, n=5151) tertiles were t1 12.1±7.4, t2 39.6±7.4 and t3 104.3±45.9 MET.hours/week. Compared to ‘sedentary’ subjects the ‘mild’ and ‘moderate’ PA tertiles had a lower risk of MACE HR 0.96 (95% CI 0.85-1.08) and 0.79 (0.70-0.91), p=0.0019, CV death 0.89 (0.75-1.06) and 0.69 (0.57-0.85), p=0.0019, and non-CV death 0.54 (0.41-0.72) and 0.72 (0.55-0.95), p&lt;.0001. See Figure. Conclusions: In patients with stable CHD there is a strong inverse association between self-reported PA and MACE, CV mortality and non-CV mortality. Even modest amounts of mild intensity exercise are associated with lower mortality.
Circumcision
Authors: Lawrence D. Freedman
Journal: JAMA (1970)

<h3>To the Editor.—</h3> In order to determine whether smegma is carcinogenic the author first cites conflicting studies. To determine if "smegma is indeed carcinogenic," he says "... Fishman's group injected smegma from old men into the vaginas of mice two to three times weekly for 12 months and was unable to stimulate the production of genital cancers..." The implication that smegma is not carcinogenic in humans was obviously not proved. In discussing Gagnon's data showing the absence of cervical carcinoma in Catholic nuns the author states that "It would appear that the decisive factor in the nuns' freedom from cervical cancer is related not to the presence or absence of the foreskin, but to the absence of sexual relations." We must disagree with the author's inference. The rarity of cervical carcinoma in persons who abstain from coitus obviously involves several factors. There is no mechanical irritation of the cervix, the cervix
Gauging Hispanic Health
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biomedically Relevant Chemical and Physical Properties of Coal Combustion Products
Authors: Gerald L. Fisher
Journal: Environmental Health Perspectives (1983)

The evaluation of the potential public and occupational health hazards of developing and existing combustion processes requires a detailed understanding of the physical and chemical properties of effluents available for human and environmental exposures. These processes produce complex mixtures of gases and aerosols which may interact synergistically or antagonistically with biological systems. Because of the physicochemical complexity of the effluents, the biomedically relevant properties of these materials must be carefully assessed. Subsequent to release from combustion sources, environmental interactions further complicate assessment of the toxicity of combustion products. This report provides an overview of the biomedically relevant physical and chemical properties of coal fly ash. Coal fly ash is presented as a model complex mixture for health and safety evaluation of combustion processes.
Physical Examination of the Abdomen in Health and Disease. Part III
Authors: C. J. B. Williams
Journal: BMJ (1851)

The following introduction to the subject of " Palpation" was inadvertently omitted at the commencement of the paper in the number for February.LIKE the sight, the touch acquaints us with the form, size, and move- ments of objects; but it further instructs us with regard to their temperature, surface-feel, consistence, resistance, and weight; and in the case of soft, pliable, and yielding objects, such as the abdomen, the touch reaches beyond the surface, and may feel more or less of all the same properties in the deeper-seated parts.Thus by palpation, or handling, of the abdomen, we may learn far more than sight can teach us, of the physical properties, and therefore of the healthy or morbid condition, of its internal organs; and the more carefully we analyze these physical properties, and understand their relations to the parts which possess them, the more instructive will be the knowledge which we derive from them.As to the sight, so also to the touch, the abdomen is made up of its walls and the viscera within them; and the latter being felt through the medium of the former, will be more or less distinct, according to the condition of the abdominal walls.When these are very thick or tense, it may be difficult to feel snything through them: when they are thin, and more especially when they are also flaccid, the condition of the contained parts may be determined with great nicety.The thickness of the walls depends chiefly on the quantity of fat, and where this is very great, palpation can only afford obscure results; the touch must be applied with considerable pressure, to reach beyond this super- ficial mass.The tension of the walls depends on the tonic contraction VOL.III.
Rethinking Somatization
Authors: Donald M. Loveman
Journal: Annals of Internal Medicine (1997)

Letters15 December 1997Rethinking SomatizationDonald M. Loveman, MDDonald M. Loveman, MDTexas Tech University Health Sciences Center; Odessa, TX 79763Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-12-199712150-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:McWhinney and colleagues' article on rethinking somatization [1] is troubling because it discusses terminology and an approach to therapy while deemphasizing cause. The authors do not point out that evidence links childhood physical; emotional; and, especially, sexual abuse with the development of subsequent somatization syndromes in adulthood. To cite a few examples: In a nonclinical sample of college-age women, Briere and Runtz [2] showed higher levels of somatization in those who reported childhood sexual abuse. Walker and colleagues [3] found a significantly higher prevalence of both somatization and history of childhood and adult sexual abuse in a ...References1. McWhinney IR, Epstein RM, Freeman TR. Rethinking somatization. Ann Intern Med. 1997; 126:747-50. Google Scholar2. Briere J, Runtz M. Symptomatology associated with childhood sexual victimization in a nonclinical adult sample. Child Abuse and Neglect. 1988; 12:51-9. Google Scholar3. Walker EA, Katon W, Hansom J, Harrop-Griffiths J, Holm L, Jones L, et al. Medical and psychiatric symptoms in women with childhood sexual abuse. Psychosom Med. 1992; 54:658-64. Google Scholar4. Drossman DA, Leserman J, Nachman G, Zhiming Le M, Gluck H, Tooney TC, et al. Sexual and physical abuse in women with functional or organic gastrointestinal disorders. Ann Intern Med. 1990; 113:828-33. Google Scholar5. Morrison J. Childhood sexual histories of women with somatization disorder. Am J Psychiatry. 1989; 146:239-41. Google Scholar Author, Article, and Disclosure InformationAuthors: Donald M. Loveman, MDAffiliations: Texas Tech University Health Sciences Center; Odessa, TX 79763 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1997Volume 127, Issue 12Page: 1132KeywordsChildrenEmotionsHand strengthSurgery ePublished: 15 August 2000 Issue Published: 15 December 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
SOME PROBLEMS OF THERAPEUTIC RESEARCH
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL SCHOOL APPLICANTS AND THE SHORTAGE OF PHYSICIANS
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Postgraduate Training in Obstetrics
Authors: M. J. Ball
Journal: BMJ (1963)

<h3>Background</h3> Electronic nicotine delivery systems (ENDS) are growing in awareness and use in the USA. They are currently unregulated as the Food and Drug Administration has yet to assert jurisdiction under its tobacco authority over these products, and a US Court of Appeals held they cannot be regulated as drugs/delivery devices if they are not marketed for a therapeutic purpose. Observation of the current online marketplace suggests ENDS, like some nutraceutical products, are being promoted using affiliate marketing techniques using claims concerning purported health benefits. <h3>Objective</h3> This study performed a forensic analysis to characterise the relationships between online ENDS affiliate advertisements and ENDS sellers, and evaluated descriptive content on advertisements and websites to inform future policy and regulatory efforts. <h3>Methods</h3> A purposive sampling strategy was used to identify three forms of ENDS advertising. Web proxy software recorded identifiable objects and their ties to each other. Network analysis of these ties followed, as well as analysis of descriptive content on advertisements and websites identified. <h3>Results</h3> The forensic analysis included four ENDS advertisements, two linked affiliate websites, and two linked seller websites, and demonstrated a multilevel relationship between advertisements and sellers with multiple layers of redirection. Descriptive analysis indicated that advertisements and affiliates, but not linked sellers, included smoking cessation claims. Results suggest that ENDS sellers may be trying to distance marketing efforts containing unsubstantiated claims from sales. A separate descriptive analysis of 20 ENDS seller web pages indicated that the use of affiliate marketing by sellers may be widespread. <h3>Conclusions</h3> These findings support increased monitoring and regulation of ENDS marketing to prevent deceptive marketing tactics and ensure consumer safety.
Cumulative incidence of financial hardship in metastatic colorectal cancer patients: Primary endpoint results for SWOG S1417CD.
Authors: Veena Shankaran, Joseph M. Unger, Amy Darke, Jennifer Marie Suga, James Lloyd Wade, Peter Kourlas, Sreenivasa R Chandana, Mark Allen O'Rourke, Suma Satti, Diane Liggett, Dawn L. Hershman, Scott David Ramsey
Journal: Journal of Clinical Oncology (2020)

7010 Background: Despite evidence that rising cancer care costs are contributing to “financial toxicity” in cancer pts, no studies, to our knowledge, have prospectively assessed the financial impact of cancer diagnosis (dx) using both self-reported and objective financial measures. S1417CD, led by the SWOG Cancer Research Network and conducted in the NCI Community Oncology Research Program (NCORP), was the first national prospective cohort study to evaluate time-to-first evidence of major financial hardship (MFH) in pts with newly diagnosed mCRC. We present results of the primary endpoint analysis. Methods: Pts age ≥ 18 within 120 days of mCRC dx receiving systemic treatment completed surveys every 3 months (mo) for 12 mo. MFH was defined as ≥ 1 occurrence of self-reported increase in debt, new loans, selling home, refinancing home, or ≥ 20% income decline during the 12 mo study period. Cumulative incidence (CI) of MFH was estimated to account for competing risk of death. Additional endpoints, not reported here, included quality of life, caregiver strain, and changes in credit status over 12 mo. Results: In total, 380 pts (median age 59.9) across 126 clinic sites were enrolled, with 377 eligible and evaluable for the primary endpoint (reached 12 mo assessment, death, or MFH endpoint); complete data were available for 92% of pts as of Jan 23, 2020. Most pts were white (78%), male (61%), and insured (98%), with annual income ≤ $50,000 (56%). Cumulative incidence of MFH at 12 mo was 71.5% (95% CI: 65.9%-76.3%), with 24.6%, 52.4%, and 61.8% at 3, 6, and 9 mo. The dominant components of MFH were new debt (12-mo CI, 56.7%) and &gt;20% decline in income (26.7%); 104 (41%) pts reported ≥ 2 elements of MFH. In a secondary analysis excluding new debt, 12 mo cumulative incidence of MFH was 42.9% (95% CI: 37.2%-48.5%), with 10.3%, 24.4%, and 31.9% at 3, 6, and 9 mo. Conclusions: In a national sample of mCRC pts on systemic tx, financial hardship, most commonly in the form of increased debt, accumulates progressively over time. Nearly 3 out of 4 pts experiencing MFH at 12 mo despite access to health insurance coverage. These findings underscore the need for clinic and policy solutions such as early financial navigation and elimination of cost sharing to protect pts from financial devastation as they continue with tx. Clinical trial information: NCI-2015-01885 . [Table: see text]
REPLY:
Authors: Wei Qiu
Journal: Hepatology (2019)

Potential conflict of interest: Nothing to report. We appreciate the positive comments on our recent publication.1 In this study, we found that overexpression of both focal adhesion kinase (FAK) and constitutively active forms of β‐catenin (CAT), but neither FAK nor CAT alone, in mouse liver was sufficient to lead to tumorigenesis. Further, we found that overexpression of FAK dramatically enhances binding of β‐catenin to the promoter of androgen receptor (AR), which leads to increased expression of AR in mouse liver. Moreover, we demonstrated that an AR degradation enhancer suppressed FAK/β‐catenin‐induced hepatocellular carcinoma (HCC) formation. Overall, these data suggest that co‐overexpression of FAK and CAT leads to HCC formation in mice through an increased expression of AR. In this article, we did not further study the molecular mechanisms by which AR promotes hepatocarcinogenesis as they have been previously extensively studied. It has been reported that AR regulates a number of downstream targets, such as enhancer of zeste homolog 2 (EZH2),2 microRNA 520f,3 and telomerase reverse transcriptase,4 to promote hepatocarcinogenesis. Therefore, we suggested that the combination of FAK plus β‐catenin induces AR and that these are possible targets to promote the development of HCC. The Alis group has previously convincingly shown that FAK depletion reduces EZH2 expression and function by modulating p53 and E2F transcription factor 2/3 transcriptional activity in HCC cells.5 I agree that our study does not rule out the possibility that there may exist a more direct interaction between FAK and EZH2 that may promote epigenetic changes occurring in hepatocarcinogenesis. Therefore, the FAK/CAT‐driven HCC model may be useful for the discovery of other FAK signaling networks including epigenetic targets for HCC treatment.
Commentaire de travail de Afghani E et al., pp. 573
Journal: Endoscopy (2014)

See also: 5-Fr vs. 3-Fr pancreatic stents for the prevention of post-ERCP pancreatitis in high-risk patients: a systematic review and network meta-analysisEndoscopy 2014; 46(07): 573-580DOI: 10.1055/s-0034-1365701
(26) Sarcoidosis
Authors: M.A. Smith
Journal: British Journal of Dermatology (1975)

Journal Article (26) Sarcoidosis Get access M.A. Smith M.A. Smith Essex County Hospital, Colchester Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 93, Issue s11, 1 July 1975, Pages 68–69, https://doi.org/10.1111/j.1365-2133.1975.tb06808.x Published: 01 July 1975
BOOK REVIEWS
Authors: L. M. ANDERSON
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article BOOK REVIEWS Get access Perinatal and Multigeneration Carcinogenesis, Volume 96 . N. P. Napalkov , J.M. Rice , L. Tomatis , H. Yamasaki , eds. New York : Oxford University Press , 1989 , 434 pp. $110. LUCY M. ANDERSON LUCY M. ANDERSON Perinatal Carcinogenesis Section Laboratory of Comparative Carcinogenesis Division of Cancer Etiology NCI-Frederick Cancer Research and Development Center Bldg538 Frederick, MD 21701 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 15, 1 August 1990, Pages 1291–1292, https://doi.org/10.1093/jnci/82.15.1291 Published: 01 August 1990