tbuckley/cabot-search huggingface dataset:
Correction: The Preventable Causes of Death in the United States: Comparative Risk Assessment of Dietary, Lifestyle, and Metabolic Risk Factors
Authors: Goodarz Danaei, Eric L. Ding, Dariush Mozaffarian, Ben Taylor, Jürgen Rehm, Christopher J. L. Murray, Majid Ezzati
Journal: PLoS Medicine (2011)

Background: Knowledge of the number of deaths caused by risk factors is needed for health policy and priority setting.Our aim was to estimate the mortality effects of the following 12 modifiable dietary, lifestyle, and metabolic risk factors in the United States (US) using consistent and comparable methods: high blood glucose, low-density lipoprotein (LDL) cholesterol, and blood pressure; overweight-obesity; high dietary trans fatty acids and salt; low dietary polyunsaturated fatty acids, omega-3 fatty acids (seafood), and fruits and vegetables; physical inactivity; alcohol use; and tobacco smoking. Methods and Findings:We used data on risk factor exposures in the US population from nationally representative health surveys and disease-specific mortality statistics from the National Center for Health Statistics.We obtained the etiological effects of risk factors on disease-specific mortality, by age, from systematic reviews and meta-analyses of epidemiological studies that had adjusted (i) for major potential confounders, and (ii) where possible for regression dilution bias.We estimated the number of disease-specific deaths attributable to all non-optimal levels of each risk factor exposure, by age and sex.In 2005, tobacco smoking and high blood pressure were responsible for an estimated 467,000 (95% confidence interval [CI] 436,000-500,000) and 395,000 (372,000-414,000) deaths, accounting for about one in five or six deaths in US adults.000; 188,000) and physical inactivity (191,000; 164,000-222,000) were each responsible for nearly 1 in 10 deaths.High dietary salt (102,000; 97,000-107,000), low dietary omega-3 fatty acids (84,000; 72,000-96,000), and high dietary trans fatty acids (82,000; 63,000-97,000) were the dietary risks with the largest mortality effects.Although 26,000 (23,000-40,000) deaths from ischemic heart disease, ischemic stroke, and diabetes were averted by current alcohol use, they were outweighed by 90,000 (88,000-94,000) deaths from other cardiovascular diseases, cancers, liver cirrhosis, pancreatitis, alcohol use disorders, road traffic and other injuries, and violence.Conclusions: Smoking and high blood pressure, which both have effective interventions, are responsible for the largest number of deaths in the US.Other dietary, lifestyle, and metabolic risk factors for chronic diseases also cause a substantial number of deaths in the US.
The clinical professor
Journal: JAMA (1982)

NOWHERE do I read of the rights or status, or even of the existence, of the clinical faculty. Having been a clinical professor for 15 years, I set down my own experience, which relates to appointments at several medical schools that shall remain nameless. I do it in writing because in my experience that is the only way that the clinical faculty can communicate with deans. I never met my deans, either before or while I was a clinical professor. Of course, my experience might be only a small, poor sample and not be representative of that of other readers who participate in clinical teaching. What do I understand a "clinical" appointment to be? I consider it to be an action by a dean of a medical school that confers the right to teach and the right to use a title. Of course, the right to teach is a magnificent
Atlas de radiographie osseuse. I. Squelette normal.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 889: Statin Treatment Ameliorates Metabolic Syndrome in Mice Lacking All Nitric Oxide Synthase Isoforms
Authors: Sei Nakata, Masato Tsutsui, Hiroaki Shimokawa, Osamu Suda, Ken Sabanai, Yasuko Yatera, Kiyoko Shibata, Tsuyoshi Morishita, Hiromi Tasaki, Yasuhide Nakashima, Nobuyuki Yanagihara, Yutaka Otsuji
Journal: Circulation (2007)

Background : We have recently succeeded in developing mice in which all three nitric oxide synthase (NOS) genes are completely disrupted (triply n/i/eNOS −/− [KO] mice) ( PNAS 2005). Our preliminary study has revealed that those mice manifest metabolic syndrome. In this study, we thus examined whether or not statin treatment ameliorates those metabolic phenotypes. Methods : Experiments regarding metabolic phenotypes were performed in 3-month-old male wild-type (WT) and triply-KO mice treated with or without atorvastatin (30 mg/kg/day, SC) for 1.5 months. Experiments regarding coronary vascular lesion formation were carried out in 5-month-old mice treated with or without atorvastatin for 2 months. Results : Hypertension (HT) (140 ± 3 vs. 110 ± 3 mmHg), hypertriglyceridemia (TG) (267 ± 15 vs. 179 ± 12 mg/dl), impaired glucose tolerance (IGT) (plasma glucose after intravenous glucose, 493 ± 38 vs. 238 ± 16 mg/dl), insulin resistance (IR) (insulin-induced [ 3 H]-glucose uptake in isolated soleus muscle, 106 ± 8 vs. 204 ± 30%), and visceral obesity (VO) (epididymal white adipose tissue weight, 0.25 ± 0.01 vs. 0.18 ± 0.01 g), were significantly noted in untreated triply-KO mice as compared with untreated WT mice (all P &lt; 0.05, n = 6 –12). Long-term treatment with atorvastatin significantly alleviated all the metabolic phenotypes in the triply-KO mice; HT (129 ± 1), TG (176 ± 11), IGT (342 ± 47), IR (120 ± 6) and VO (0.17 ± 0.01) (all P &lt; 0.05, n = 6 –12). Importantly, significant coronary vascular lesions, as characterized by neointimal formation (NF) (intima/media ratio, 0.15 ± 0.01 vs. 0.01 ± 0.01), medial thickening (MT) (media/vascular ratio, 0.43 ± 0.07 vs. 0.13 ± 0.01), and perivascular fibrosis (PF) (fibrosis/vascular ratio, 0.38 ± 0.05 vs. 0.18 ± 0.03) (all P &lt; 0.05), were spontaneously developed in the untreated triply-KO mice as compared with the untreated WT mice, all of which changes were again significantly suppressed by the atorvastatin treatment; NF (0.06 ± 0.02), MT (0.32 ± 0.02), and PF (0.17 ± 0.02) (all P &lt; 0.05, n = 6 each). Conclusions : These results provide the first evidence that statin treatment ameliorates metabolic syndrome as well as coronary arteriosclerosis in the presence of defective NOSs system, suggesting a novel therapeutic strategy for the disorder.
Abstract 80: Electronic cigarette aerosols increase clonogenic survival in oral cancer cells after cisplatin treatment
Authors: Jimmy Manyanga, Toral R. Mehta, Lurdes Queimado
Journal: Cancer Research (2019)

Abstract Background and Aim: Are electronic cigarettes (ECs) safer than combustible tobacco? No one knows the answer yet. ECs are devices that deliver an aerosol from a heated mixture of propylene glycol, vegetable glycerin, and flavors, with or without nicotine. Short-term EC studies are mostly limited and inconclusive. Despite unknown long-term health effects, the use of ECs has increased alarmingly over the past decade. EC aerosols contain unique chemicals as well as other chemicals similar to those found in tobacco smoke. Tobacco smoking during cancer treatment has been associated with increased drug resistance and reduced overall survival rate. The awareness of the dangers of cigarette smoking and the paucity of studies evaluating the safety of ECs pose a dilemma for cancer patients who might be considering switching to ECs during chemotherapy. Here, we sought to examine the effects of EC aerosol extracts exposure on cell survival in oral cancer cells during cisplatin treatment. Methods: EC aerosol extracts were collected from two brands of ECs as previously described. Mainstream tobacco smoke (MS) extract was used as a positive control. To evaluate clonogenic survival after cisplatin treatment, oral cancer cells were exposed for 48 h to EC aerosol extracts at nicotine doses comparable to those observed in EC users. Next, cells were treated with both EC aerosol extracts and cisplatin (or vehicle-control) for another 48 h. After treatment, cells were counted and seeded in 6-well plates and colony formation was assessed two weeks later. Colonies were fixed with methanol followed by staining with 0.5% crystal violet in 25% methanol and counted manually. Only colonies with at least 50 cells were counted. Data were analyzed by Student's t-tests and one-way analysis of variance (ANOVA). Results: After cisplatin treatment, cells exposed to EC aerosol extracts showed a significant increase in clonogenic survival fraction compared to vehicle-control treated cells. Furthermore, cells exposed to EC aerosol extracts formed visibly larger colonies. An increase in clonogenic survival was also observed in MS extract-treated cells. Conclusions: Collectively, our data suggest that short-term exposure to EC aerosol can induce cisplatin resistance in oral cancer cells, thus allowing the cells to survive and form colonies. These findings are particularly important in paving the way to understanding whether ECs are a safer alternative for oral cancer patients undergoing chemotherapy. Citation Format: Jimmy Manyanga, Toral R. Mehta, Lurdes Queimado. Electronic cigarette aerosols increase clonogenic survival in oral cancer cells after cisplatin treatment [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 80.
Hyperbaric oxygen treatment of gangrene in pneumococcemia
Authors: S. C. Karz
Journal: JAMA (1971)

In a man with bilateral symmetrical gangrene resulting from pneumococcemia, hyperbaric oxygen therapy was successful after a trial of antibiotics, vasodilators, and nerve block had proved of no avail. Treatment consisted of 2 atmospheres absolute oxygen, two hours twice daily for 4 days, then 2 atm absolute, two hours for 11 days. A dramatic response was noted during the first treatment.
2014 ACC/AHA Guideline on Perioperative Cardiovascular Evaluation and Management of Patients Undergoing Noncardiac Surgery: Executive Summary
Authors: Lee A. Fleisher, Kirsten E. Fleischmann, Andrew D. Auerbach, Susan A. Barnason, Joshua A. Beckman, Biykem Bozkurt, Victor G. Davila-Roman, Marie D. Gerhard-Herman, Thomas A. Holly, Garvan C. Kane, Joseph E. Marine, M. Timothy Nelson, Crystal C. Spencer, Annemarie Thompson, Henry H. Ting, Barry F. Uretsky, Duminda N. Wijeysundera
Journal: Journal of the American College of Cardiology (2014)
THE ABUSE OF MEDICAL CHARITY.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Studies of the Blood-Cerebrospinal Fluid Barrier to Cortisol in the Dog
Journal: Journal of Clinical Investigation (1961)

rections proposed here do not lead to a corrected A-V difference that differs from the simultaneous A-V difference at time t by more than the experimental error of measurement of an A-V differ- ence, it is probably safe to regard the functions as constant.The effect of the non-steady state on simultaneous A-V differences means that a solitary A-V difference is uninterpretable.The immediate history of the system must be known.A single pair of A-V differences determined simul- taneously on two substances passing through the same bed is also not properly useful for compar- ing the relative metabolism of the two substances unless it is known that the distributions of their transit times are identical.
Abstract 3757: Targeted Inactivation of Receptor for Advanced Glycation Products Reduced Oxidative LDL-Induced Inflammation and Atherosclerosis in Non-Diabetic LDL Receptor−/− Mice
Authors: Li Sun, Tatsuro Ishida, Masamitsu Kuriyama, Tomoyoki Yasuda, Tetsuya Hara, Kenichi Hirata, Yoshitake Hayashi
Journal: Circulation (2008)

Receptor for advanced glycation products (RAGE) is a multiligand receptor on vascular cells and plays an important role in the progression of diabetic complications. To define if RAGE modulates atherosclerosis under non-diabetic conditions, we examined the effect of RAGE deficiency in non-diabetic mice with hyperlipidemia. RAGE knockout mice (RAGE−/−) were bred with low-density lipoprotein receptor knockout (LDLr−/−) mice to generate the double knockout (DKO) mice. The mice were fed with western diet for 12 weeks, and aortic atherosclerotic lesions were analyzed histologically. Although there was no difference in body weight, fasting blood glucose and serum AGE levels between DKO and LDLr−/− mice, DKO mice exhibited a significant decrease in the size and macrophage content in atherosclerosis lesions compared with LDLr−/− mice. Expressions of endothelial adhesion molecules such as VCAM-1 and ICAM-1 in the aorta were lower in DKO mice than those in LDLr−/− mice. Chemiluminescence and fluorescence-based assays revealed that DKO mice showed lower oxidative stress in the vessel wall than LDLr−/− mice. Complementary in vitro studies revealed that peritoneal macrophages isolated from RAGE−/− mice exhibited a decrease in oxidative LDL (oxLDL)-induced ERK activation and proliferation when compared to RAGE+/+ macrophages. In contrast, overxpression of RAGE in COS7 cells resulted in the augmented ERK activation in response to oxLDL, which is abolished by the co-incubation with anti-RAGE blocking antibodies. The results indicated that oxLDL activated RAGE and increased oxidative stress via NADH/NADPH oxidase pathway. OxLDL may serve as a new ligand for RAGE. RAGE inactivation inhibits atherosclerosis by reducing pro-inflammatory and oxidative stress under the hyperlipidmic, non-diabetic condition.
Editorial_Board
Authors: Carmen Allegra, Patricia Ganz, Frederic Deputy, Frederic Kaye, Douglas Weed Reviews, Neil Aaronson, Adriana Albini, Christine Ambrosone, Wendy Atkin, Mariano Barbacid, Stacey Berg, Russell Berman, Michael Birrer, William Blot, Peter Blumberg, Cameron Brennan, Louise Brinton, Powel Brown, Stephen Chanock, Graham Colditz, Nancy Davidson, Ethan Dmitrovsky, Craig Earle, Rosalind Eeles, Susan Ellenberg, Joann Elmore, Manel Esteller, Robert Ferris, Olivera Finn, Elizabeth Fox, Mitchell Gail, Ann Geiger, Edward Giovannucci, Paul Godley, John Gohagan, Ellen Goode, Michael Gottesman, Peter Greenwald, Stephen Gruber, James Gulley, Stephen Hahn, Daniel Haller, Kathy Helzlsouer, Dawn Hershman, Howard Hochster, Arti Hurria, Jean-Pierre Issa, Holly Janes, Colin Jefcoate, Lisa Kachnic, Nancy Keating, Bernard Levin, Isra Levy, W Linehan, Marc Lippman, Scott Lippman, Dan Longo, Douglas Lowy, Jeanne Mandelblatt María, Elena Martínez, Mads Melbye, Bruce Minsky, Paul Mischel, Halle Moore, Sarah Nechuta, Charles Perou, Ulrike Peters, Lajos Pusztai, Alan Rabson, David Ransohoff, Jorge Reis-Filho, Harvey Risch, Mark Robson, Edward Sausville, Deborah Schrag, Arnold Schwartz, Mark Sherman, Robert Shoemaker, Richard Simon, Margaret Spitz, Giovanna Tosato, Christina Tsien, Sally Vernon, Jeffrey Weber, Douglas Weed, John Wingard, K Yabroff, Regina Ziegler, Janet Andersen, Hanna Bandos, Roula Barhoumi, William Barlow, Donald Berry, Jinbo Chen, Bernard Cole, David Conti, Michele Cote, Chad Creighton, Catherine Crespi, Kathleen Cronin, James Dignam, Kevin Dobbin, Carol Etzel, Ruth Etzioni, Richard Fagerstrom, Paul Fishman, Mary Foulkes, Paul Frankel, Brooke Fridley, Barry Graubard, Susan Groshen, Summer Han, Michael Hauptmann, Daniel Heitjan, Vivian Ho, Hormuzd Katki, Victor Kipnis, Charles Kooperberg, Edward Korn, J Lee, Yimei Li, Yan Lin, Hao Liu, Lei Liu, Yong Ma, Stefan Michiels, Ann Partridge, Ruth Pfeiffer, Meng Qian, Philip Rosenberg, Larry Rubinstein, Joshua Sampson, Mark Segal, Jianxin Shi, Camelia Sima, Donald Stablein, Seth Steinberg, Lisa Wang, Wenjian Yang, Greg Yothers, Kai Yu, Hans-Olov Adami, Harry Burke, Pelayo Correa, Soldano Ferrone, Isaiah Fidler, Curtis Harris, Emily Harris, Allan Hildesheim, Waun Ki, Hong Peter, J Houghton, David Johnson, V Craig, Jordan Ilan, R Kirsch, Kenneth Kraemer, Alexandra Levine, Martha Linet, Henry Lynch, Pamela Marcus, Frank Meyskens, Anthony Miller, David Schottenfeld, Jerry Shay, Debra Silverman, G Swanson, Mario Sznol, Jeannine Botos, Senior Editors, Amanda Boehm, Beatrice Grabowski, Meredith Abel, Tyler Lowry, Jan Martin, Zachary Rathner, Anna Azvolinsky, Vicki Brower, Mike Fillon, Karyn Hede, Norra Macready, Charles Schmidt
Journal: JNCI Journal of the National Cancer Institute (2015)
Anti-Inflammatory Curcumin Inhibits Activation-Induced Cytosine Deaminase (AID) within Cycling Normal and CLL B Lymphocytes.
Authors: Shabirul Haque, Bukhtawar Waqas, Hyunjoo Lee, Piers EM Patten, Jonathan E Kolitz, Steven L Allen, Kanti R Rai, Nicholas Chiorazzi, Patricia KA Mongini
Journal: Blood (2010)
Die Ohrenkrankheiten im Kindesalter mit Einschluss der Grenzgebiete.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Single-dose therapy for cystitis in women. A comparison of trimethoprim-sulfamethoxazole, amoxicillin, and cyclacillin
Authors: T. M. Hooton
Journal: JAMA (1985)

We evaluated single-dose regimens of trimethoprim-sulfamethoxazole, amoxicillin, and cyclacillin as treatment for acute cystitis in 38 women. The trial was prematurely stopped because of frequent treatment failures. At two days after treatment, all 13 patients given trimethoprim-sulfamethoxazole were cured, while four (31%) of 13 given amoxicillin and four (33%) of 12 given cyclacillin had persistent bacteriuria. At two weeks, 11 (85%) of 13 patients given trimethoprim-sulfamethoxazole, six (50%) of 12 given amoxicillin, and three (30%) of ten given cyclacillin were cured. One patient with positive results of antibody-coated bacteria testing who was treated with cyclacillin had signs and symptoms of acute pyelonephritis three days after treatment, and two patients treated with amoxicillin and one treated with trimethoprim-sulfamethoxazole converted antibody-coated bacteria test results from negative to positive after therapy. We conclude that single-dose treatment of cystitis in unselected women with cyclacillin and amoxicillin may result in low cure rates and that progression to acute pyelonephritis may occur following ineffective single-dose therapy. (<i>JAMA</i>1985;253:387-390)
BELGIUM
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of live, attenuated measles virus vaccine in children allergic to egg protein
Authors: P. B. Kamin
Journal: JAMA (1965)

RECENT REPORTS<sup>1</sup>indicate that the administration of measles vaccine for active immunization of susceptible children has not yet reached desirable levels, and that 20 million children under the age of 10, living in the United States, are unprotected. Several factors probably account for this, including lack of information, cost of the procedure, and the possibility or fear of reaction. The latter has been specifically related to egg-allergic children, of whom there are conservatively estimated to be over 50,000 among the allergic pediatric population of the United States. Since reactions to virus vaccines have occurred in the past among eggallergic children,<sup>2-4</sup>the manufacturers of virus vaccines have routinely cautioned that such children should not receive live, attenuated virus vaccine immunizations. In a previous study,<sup>5</sup>we administered live, attenuated measles virus vaccine to 11 children from 1 to 6 1/2 years of age, each of whom repeatedly demonstrated severe