<i>WT1</i> and <i>DNMT3A</i> play essential roles in the growth of certain patient AML cells in mice
Authors: Maryam Ghalandary, Yuqiao Gao, Diana Amend, Ginte Kutkaite, Binje Vick, Karsten Spiekermann, Maja Rothenberg-Thurley, Klaus H. Metzeler, Anetta Marcinek, Marion Subklewe, Michael P. Menden, Vindi Jurinovic, Ehsan Bahrami, Irmela Jeremias
Journal: Blood (2022)

Letter to Blood| February 23, 2023 WT1 and DNMT3A play essential roles in the growth of certain patient AML cells in mice Maryam Ghalandary, Maryam Ghalandary ∗ Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany Search for other works by this author on: This Site PubMed Google Scholar Yuqiao Gao, Yuqiao Gao ∗ Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany Search for other works by this author on: This Site PubMed Google Scholar Diana Amend, Diana Amend Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany Search for other works by this author on: This Site PubMed Google Scholar Ginte Kutkaite, Ginte Kutkaite Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, GermanyDepartment of Biology, Ludwig-Maximilians University Munich, Martinsried, Germany https://orcid.org/0000-0002-2918-294X Search for other works by this author on: This Site PubMed Google Scholar Binje Vick, Binje Vick Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, GermanyGerman Cancer Consortium, Partner Site Munich, Munich, Germany https://orcid.org/0000-0003-1956-2778 Search for other works by this author on: This Site PubMed Google Scholar Karsten Spiekermann, Karsten Spiekermann Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, Ludwig Maximilians University, Munich, Germany https://orcid.org/0000-0002-5139-4957 Search for other works by this author on: This Site PubMed Google Scholar Maja Rothenberg-Thurley, Maja Rothenberg-Thurley Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, Ludwig Maximilians University, Munich, Germany Search for other works by this author on: This Site PubMed Google Scholar Klaus H. Metzeler, Klaus H. Metzeler Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, Ludwig Maximilians University, Munich, GermanyDepartment of Hematology and Cell Therapy, University Hospital Leipzig, Leipzig, Germany https://orcid.org/0000-0003-3920-7490 Search for other works by this author on: This Site PubMed Google Scholar Anetta Marcinek, Anetta Marcinek Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, Ludwig Maximilians University, Munich, Germany Search for other works by this author on: This Site PubMed Google Scholar Marion Subklewe, Marion Subklewe Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, Ludwig Maximilians University, Munich, Germany https://orcid.org/0000-0003-3905-0251 Search for other works by this author on: This Site PubMed Google Scholar Michael P. Menden, Michael P. Menden Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, GermanyDepartment of Biology, Ludwig-Maximilians University Munich, Martinsried, GermanyGerman Centre for Diabetes Research, Neuherberg, Germany https://orcid.org/0000-0003-0267-5792 Search for other works by this author on: This Site PubMed Google Scholar Vindi Jurinovic, Vindi Jurinovic Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany Search for other works by this author on: This Site PubMed Google Scholar Ehsan Bahrami, Ehsan Bahrami Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany https://orcid.org/0000-0002-1672-5503 Search for other works by this author on: This Site PubMed Google Scholar Irmela Jeremias Irmela Jeremias Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, GermanyGerman Cancer Consortium, Partner Site Munich, Munich, GermanyDepartment of Pediatrics, University Hospital, Ludwig Maximilians University, Munich, Germany https://orcid.org/0000-0003-1773-7677 Search for other works by this author on: This Site PubMed Google Scholar Blood (2023) 141 (8): 955–960. https://doi.org/10.1182/blood.2022016411 Article history Submitted: March 23, 2022 Accepted: September 25, 2022 Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Request Permissions Cite Icon Cite Search Site Citation Maryam Ghalandary, Yuqiao Gao, Diana Amend, Ginte Kutkaite, Binje Vick, Karsten Spiekermann, Maja Rothenberg-Thurley, Klaus H. Metzeler, Anetta Marcinek, Marion Subklewe, Michael P. Menden, Vindi Jurinovic, Ehsan Bahrami, Irmela Jeremias; WT1 and DNMT3A play essential roles in the growth of certain patient AML cells in mice. Blood 2023; 141 (8): 955–960. doi: https://doi.org/10.1182/blood.2022016411 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBlood Search Subjects: Myeloid Neoplasia TO THE EDITOR: Patients with acute myeloid leukemia (AML) experience poor prognosis, and precision oncology represents an attractive therapeutic option, applying targeted therapies against so-called dependencies.1-4 Dependencies are essential components required for cell growth and survival; they represent attractive therapeutic targets as their inhibition reduces tumor burden.1-4 Many genes recurrently mutated in AML contribute to oncogenesis,5,6 which may imply a role as dependency and allow precision therapy, based on genetic profiling. Examples already in routine clinical practice include AML with mutated FMS related receptor tyrosine kinase 3 treated with midostaurin and AML with mutated isocitrate dehydrogenase responding to ivosidenib.2 Herein, we asked whether additional recurrently mutated genes might represent dependencies in established AML. Previous efforts to identify dependencies used established cell lines, including large-scale functional genomic screens; WT1 and DNMT3A were shown to be dispensable... References 1.Kantarjian H, Kadia T, DiNardo C, et al. Acute myeloid leukemia: current progress and future directions. Blood Cancer J. 2021;11(2):41.Google ScholarCrossrefSearch ADS PubMed 2.Short NJ, Konopleva M, Kadia TM, et al. Advances in the treatment of acute myeloid leukemia: new drugs and new challenges. Cancer Discov. 2020;10(4):506-525.Google ScholarCrossrefSearch ADS PubMed 3.Park JJH, Hsu G, Siden EG, Thorlund K, Mills EJ. 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Oncogenesis. 2020;9(2):7.Google ScholarCrossrefSearch ADS PubMed © 2023 by The American Society of Hematology2023 © 2023 by The American Society of Hematology2023 You do not currently have access to this content. Sign in via your Institution