tbuckley/cabot-search huggingface dataset:
AB0041 IDENTIFICATION AND PROPERTIES OF EXOSOMES (EX) OF SYNOVIAL FLUID (SF) WITH GONARTROSIS (GA)
Authors: E. De La Poza Plaza, V. Shishkin, V. V. Shishkin, G. V. Kudryavtseva, S. Barykin
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> EX - poorly studied extracellular vesicles, 30-150 nm in diameter, found in various biological fluids and have high functional activity, including immunomodulatory effects. <h3>Objectives</h3> The participation of EX in the development of complex connective tissue immunopathology requires further study. The aim of the work was to study EX of SF in GA. <h3>Methods</h3> SF of knee joints of 12 patients with GA with active synovitis and 7 conditional donors postmortem (D) were researched. EX was isolated by ultrafiltration and double ultracentrifugation (105 g).EX was identified by transmission electron microscopy and flow cytometry. Electrokinetic mobility (EM) determined by the automatic microscope. Registration of the active forms of oxygen (AFO2) was carried out by EPR. The activity of Cu-Zn superoxidismutase (Cu-Zn SOD), as well as DNA and RNA levels, was estimated by employing classical biochemistry methods. <h3>Results</h3> The EX population undergoes significant morphofunctional changes in GA: EX become smaller, their diameter decreases by an average of 2.5 times, and the value of the negative surface charge changes to 45.5%. EM EX at GA increases by 2.4 times. Against the background of the intensification of free radical processes in EX with GA, a decrease in the activity (on average by 1.7 times) of the pathogenic protein Cu-Zn-SOD is observed. The pronounced secretion of EX in GA is accompanied by an enhanced synthesis of information molecules, especially DNA, the amount of which increases by an average of 2 orders of magnitude (Тable 1). At the same time, the floating density of EX in the sucrose gradient (g/ml) is normally 1.24 ± 0.09, and at GA 2.52 ± 0.14*. <h3>Conclusion</h3> The molecular mechanisms of GA progression are associated with the ability of EX to influence intercellular communication, epigenetically reprogram various target cells, activate protein biosynthesis, and be carriers of a number of mediators. Violation of exosomal immune intercellular communications, apparently, underlies the development of a variety of pathologies, including systemic connective tissue diseases. <h3>Reference</h3> [1]Shishkin V.I. et al. DOI:10.1136/annrheumdis-2020-eular.1154 P346 <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1587 EXPERIENCE IN REAL-WORLD CONDITIONS OF THE EFFECTIVENESS OF THE VACCINE AGAINST HERPES ZOSTER
Authors: L. Mas Sanchez, P. Muñoz Martinez, E. Grau García, A. M. Torrat Noves, D. Ramos Castro, C. Riesco Barcena, A. V. Huaylla Quispe, S. Leal Rodriguez, I. Cánovas Olmos, H. Charia, L. Gonzalez Puig, J. Ivorra Cortés, I. Martínez Cordellat, C. Nájera Herranz, R. Negueroles Albuixech, J. E. Oller Rodríguez, F. Ortiz-Sanjuán, E. Tovar-Sugrañes, E. Vicens Bernabeu, J. A. Román Ivorra
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Herpes zoster infection is due to the reactivation of the varicella-zoster virus (VZV), having a high prevalence in elderly and immunocompromised patients. Since the beginning of 2022, a new vaccine that prevents herpes zoster virus reactivation has been approved and commercialized. However, there are few studies analyzing its effectiveness in real-world conditions. <h3>Objectives</h3> To analyze the incidence and rate of herpes zoster disease in a population at risk due to suffering from rheumatic diseases and therefore being subsidiary of receiving VZV vaccination. <h3>Methods</h3> A retrospective observational study of patients who started treatment with JAK inhibitors from 2013 to 2022 was performed. Demographic and clinical variables were collected from the electronic clinical history. Vaccination of patients against VZV was analyzed, as well as the incidence of herpes simplex (HSV) and herpes zoster reactivation before and after January 2022, date on which the vaccination program began. In addition, the rate of the VZV disease was calculated based on the follow-up time for both vaccinated and unvaccinated patients and was adjusted by exposure in events/100 patients-year (E/100 PY). <h3>Results</h3> 236 patients with an indication for vaccination against VZV due to being treated with JAK inhibitors were included, of whom the majority diagnosis was Rheumatoid Arthritis (n=179). Their characteristics are shown in the following Table 1. 30 patients were vaccinated against VZV (12.71%). An incidence of 20 herpes cases was observed in unvaccinated patients (8 HSV and 12 VZV). 3 of the VZV reactivations were of multimetameric involvement. No cases of herpes were found in the vaccinated population. The unvaccinated patients were followed up for 3500 months, remaining with a herpes rate in this population of 4.12 E/100 PY. The total follow-up of vaccinated patients was 102 months, with a herpes rate of 0 E/100 PY. <h3>Conclusion</h3> An incidence of 12 VZV is observed in unvaccinated patients compared to an incidence of 0 in vaccinated patients. The herpes rate in non-vaccinated patients was 4.12 E/100 PY compared to 0 E/100 PY in vaccinated patients. Therefore, we conclude that the herpes zoster vaccine shows its effectiveness in our population but it would be necessary to carry out more studies in the future with a longer follow-up time. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1198 CLINICAL PROFILE OF HAND OSTEOARTHRITIS IN A LOW INCOME POPULATION
Authors: F. De Azevedo, J. P. Borges, G. Da Silva, J. C. Costa Junior, J. E. Fonseca, F. A. Castro Rocha
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> hand osteoarthritis (HOA) is a highly prevalent disease that may be impacted by social inequalities. However, there are few studies on HOA from underdeveloped regions. <h3>Objectives</h3> to present clinical characteristics of a HOA cohort from a low-income population. <h3>Methods</h3> clinical data and serum from 70 patients with a diagnosis of HOA fulfilling ACR criteria seen between March 2020 and December 2022 in Fortaleza/Brazil registering hypertension, diabetes, obesity (BMI&gt;30 kg/m²), and concurrent diagnosis of knee or spine OA and "bunions"; pain (VAS, visual analogue scale), X-ray (Kellgren-Lawrence) and ultrasonography (US) [synovitis and power-doppler (PD) sign] of the most affected joint of the hand were recorded, as well as grip and pinch strength (KgF), Cochin hand functional scale (CHFS), FIHOA, and SF-12 scores. Social data included income, occupation [white (WCJ) <i>vs.</i> blue (BCJ) colar jobs], education level [&gt;/≤ 8 school-years (SY)]. <h3>Results</h3> 70 patients were included, comprising 66(94%) women, mean age 60.3±10.3 with 12(17.1%) below 50 years-old; median disease duration was 72(range 30-120) months. Pain on movement (VAS) was 7.4±1.9, grip strength 14.5±6.4, pinch strength 1.7±1, CHFS 21±14.8, FIHOA 10.3±6.2, and SF-12 32.1±3; 54(77.1%) had KL≥3. All but 2 out of 61 evaluated joints had synovitis at US with only 4(6.7%) displaying positive PD signal; 27(38.5%) had isolated HOA; 9(12.8%), 8(11.4%), and 5(7.1%) had concurrent spine or knee OA or bunions, respectively and 22(31.4%) had ≥2 sites other than HOA; 31(44.2%), 16(22.8%), and 7(10%) had hypertension, obesity and diabetes as comorbidities, respectively; 38(54.2%) declared &lt;900 US$ monthly family earnings, 8(11.4%) had &lt;8SY and 27(38.5%) had occupations classified as BCJ. Mean pain was similar regardless of occupation, literacy (SY) or monthly family income. Although pain in BCJ group (7.9±1.7) was higher than in WCJ group (7.1±2) it did not reach statistical significance (p=0.0576); CHFS, FIHOA and SF-12 scores were similar regardless of occupation, SY or income; total mean CRP was 0.41±0.64 mg/dL; mean CRP in those with concurrent knee OA (0.38±0.25 mg/dL) had a trend to be higher than in isolated HOA patients 0.24±0.1 mg/dL (p=0.0547). <h3>Conclusion</h3> Our results suggest that income and literacy did not influence disease severity in HOA in our low income cohort. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
Outcomes of Patients With Myeloproliferative Neoplasms Admitted With Myocardial Infarction
Authors: Orly Leiva, Yuhe Xia, Emaad Siddiqui, Gabriela Hobbs, Sripal Bangalore
Journal: JACC CardioOncology (2023)

Myeloproliferative neoplasms (MPNs) are hematopoietic stem cell neoplasms with a high risk of thrombosis, including acute myocardial infarction (AMI). However, outcomes after AMI have not been thoroughly characterized.The purpose of this study was to characterize outcomes after AMI in patients with MPNs compared with patients without MPNs.Patients with a primary admission of AMI from January 2006 to December 2018 were identified using the National Inpatient Sample. Outcomes of interest included in-hospital death or cardiac arrest (CA) and major bleeding. Propensity score weighting was used to compare outcomes between MPN and non-MPN groups.A total of 1,644,304 unweighted admissions for AMI were included; of these admissions, 5,374 (0.3%) were patients with MPNs. After propensity score weighting, patients with MPNs had a lower risk of in-hospital death or CA (OR: 0.83; 95% CI: 0.82-0.84) but a higher risk of major bleeding (OR: 1.29; 95% CI: 1.28-1.30) compared with non-MPN patients. There was a decreasing temporal rate of in-hospital death or CA and bleeding in patients without MPNs (Ptrend < 0.001 for both). However, there was an increasing temporal rate of in-hospital death or CA (Ptrend < 0.001) and a stable rate of major bleeding (Ptrend = 0.48) in patients with MPNs.Among patients hospitalized with AMI, patients with MPNs have a lower risk of in-hospital death or CA compared with patients without MPNs, although they have a higher risk of bleeding. More investigation is needed in order to improve post-AMI bleeding outcomes in patients with MPN.
AB1116 APREMILAST IN PSORIATIC ARTHRITIS. ULTRASOUND ANALYSIS (JOINT-ENTHESES-UNGUEAL INDEX) OF THE EFFICACY AND VARIABLES CORRELATION STUDY
Authors: J. J. De Agustin, G. Añez, D. Reina-Sanz, S. Heredia, J. Ramirez, A. Cuervo, J. Rodríguez, C. Moragues Pastor, P. Moya, A. Laiz, M. Moreno, M. Arévalo, M. Pujol Busquets, G. Salvador Alarcon, N. Busquets-Pérez, A. Ponce Fernandez, M. Pascual-Pastor
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> We conducted a study using ultrasonography (US) to evidence inflammatory changes (joint-enthesis-ungueal) in active PsA (aPsA) patients who started Apremilast (A) in clinical practice. <h3>Objectives</h3> Obtain a 20, 50, 70 % reduction in the US index (UIC) at 12 months, and study correlation between variables. <h3>Methods</h3> <i>Phase IV, multicenter, prospective and open-label clinical trial</i> conducted <i>in 9 centres</i> from 2018 to 2021. All patients signed the informed consent. Approval by the ethical committee was obtained, code PSA-PI-006421. PsA patients (≥ 2 swollen joints), ≥ 2 joint US synovitis and ≥ 1 US enthesitis at screening were recruited. 52 weeks follow up (baseline, 1, 6, 9 &amp; 12 months). US &amp; clinic variables, and ESR &amp; CRP were registered at each visit. US scans were scored according to Ficjan et al [1]. Ungueal nail plate (NP) and subungueal thickness (ST) US evaluation of 2<sup>nd</sup>, 3rd and 5<sup>th</sup> finger was done. <h3>Results</h3> 48 patients screened and 46 included (2 screening failure) in follow up. 26 completed the study. A 20 % (main objective) reduction in UIC was obtained, until 40%, but not 50/70%. Clinical and US variables were reduced, ESR and CRP did not change during follow-up (Table 1). Strong correlation was observed between UIC and SJC, moderate between UIC and TJC, PGA, PtGA, CRP. A reduction in clinical onychopathy, NP lesion, and slight relation between lesion, and high ST and ST with onychopathy was seen but didn't achieve statistical significance (reduced sample size). 75 adverse events in 33 patients were registered, only 1 severe. Reasons for withdrawal were: 6 patients AE, 8 no efficacy, and 6 other reasons (loss of follow-up, withdrawal of consent). <h3>Conclusion</h3> Apremilast is a safe, well tolerated, and useful treatment in different patterns of PsA (joint, enthesis) demonstrated by an ultrasonography score. Ultrasound can identify nail disease in PsA patients. <h3>Reference</h3> [1]Ficjan A, Husic R, Gretler J, Lackner A, Graninger WB, Gutierrez M, et al. Ultrasound composite scores for the assessment of inflammatory and structural pathologies in Psoriatic Arthritis (PsASon-Score). Arthritis Res Ther. 2014;16(1):1–13. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
POS1377 HAND OSTEOARTHRITIS: CORRELATION BETWEEN HAND ULTRASOUND AND CONVENTIONAL RADIOGRAPHY
Authors: H. Boussaa, S. Bouzid, S. Miladi, A. Fazaa, M. Yasmine, L. Souabni, K. Ouenniche, S. Kassab, C. Selma, K. Ben Abdelghani, A. Laatar
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Hand osteoarthritis (OA) is among the most prevalent OA phenotypes. The simultaneous involvement of multiple hand joints makes hand OA a heterogeneous disorder that is complex to study [1]. It is widely accepted that radiography is the gold standard for the diagnosis of hand OA [2]. <h3>Objectives</h3> We aimed to investigate the correlation between ultrasound (US) and X-ray findings in hand OA. <h3>Methods</h3> We conducted a cross-sectional study, including patients with hand OA, fulfilling American College of Rheumatology criteria. All patients underwent a physical examination followed by an US exam. US was performed in all metacarpophalangeal, proximal interphalangeal, and distal interphalangeal joints, and features were quantitatively scored (0/1). Recent (less than six months old) posterior-anterior view X-rays of the hands were analyzed. Pearson correlation coefficient was calculated. <h3>Results</h3> We examined 280 joints in a total of 10 patients with hand OA (9 women and one man). The mean age was 66±11 years [46–78]. The mean duration of hand OA symptoms was 4±3 years. The mean tender and swollen joints were 1.5 [0-5] and 0.1 [0-1], respectively. X-rays showed joint space narrowing and osteophytes in all patients. Sclerosis was found in 2,4 [0-8] joints. A significant correlation was found between the number of osteophytes in both US and X-rays (p&lt;0.001). Joint space narrowing was correlated to calcifications (p=0.003) and enthesophytes (p=0.039). X-rays subchondral cysts correlated with osteophytes (p=0.015) and calcifications (p=0.04) in US. No significant association was noted between sclerosis and US findings. <h3>Conclusion</h3> Despite the small study population, our results showed a significant match between US and X-ray in hand OA. This finding is likely to have practical implications for facilitating the diagnosis and the monitoring of hand OA. <h3>References</h3> [1]Kloppenburg M, Kwok WY. Hand osteoarthritis—a heterogeneous disorder. Nat Rev Rheumatol. Jan 2012;8(1):22‑31. [2]Zhang W, Doherty M, Leeb BF, Alekseeva L, Arden NK, Bijlsma JW, et al. EULAR evidence-based recommendations for the diagnosis of hand osteoarthritis: report of a task force of ESCISIT. Ann Rheum Dis. Jan 2009;68(1):8‑17. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
POS1121 IMPACT OF SUBCLINICAL ANKLE AFFECTION ON THE FUNCTIONAL STATUS OF RHEUMATOID ARTHRITIS PATIENTS: AN ULTRASOUND-BASED STUDY
Authors: M. G. Abdelzaher, S. Finzel, A. Abdelsalam, A. Enein, N. Abdelsalam
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Subclinical involvement of the ankles is common in rheumatoid arthritis (RA) and occurs even in patients in clinical remission<sup>[1]</sup>. Assessing the characteristics of ankle inflammation and its effect on the functional status will enable the clinician to target treatment interventions<sup>[2]</sup>. Ankle joint is underrepresented in many clinical, sonographic RA-scores, and there is little information available in the literature about ultrasound (US) evaluation of asymptomatic ankle pathologies in RA patients. <h3>Objectives</h3> To assess the impact of US diagnosed subclinical ankle pathologies on the functional status of RA patients. <h3>Methods</h3> The study included 52 RA patients without ankle pain and 52 healthy age, gender matched controls. Ankle joints were examined clinically then by US using gray scale (GS) and Power Doppler (PD) including tibiotalar (TTJ), subtalar (STJ), talonavicular (TNJ), calcaneo-cuboid joints. In addition, tibialis anterior (TA), extensor hallucis longus (EHL), extensor digitorum longus (EDL), tibialis posterior (TP), flexor digitorum longus (FDL), flexor hallucis longus (FHL), peroneus longus, brevis and achilles tendons (AT), retrocalcaneal bursa (RCB) and plantar fascia (PF) were assessed. Functional capacity was measured using Health Assessment Questionnaire (HAQ) and Foot Function Index (FFI) <h3>Results</h3> Data showed significantly more GSUS pathologies in the asymptomatic RA group than in the control group in TP (27.9% vs 3.8%) (P=0.043), FDL (3.8% vs 0%) (P=0.043), and peroneal tenosynovitis (26% vs 0%) (P&lt;0.001), TTJ (23.1% vs 5.8%) (0.024) and TNJ synovitis (23.1% vs 3.8%) (P=0.024), AT tendinitis (19.2% vs 4.8%) (P=0.01), RCB bursitis (13.5% vs 1.9%) (P=0.002), STJ (13.5% vs 0%) (P=0.024), and calcaneo-cuboid joint synovitis (4.8% vs 0%) (P=0.024). Pathologies; see Figure 1. There was a trend to statistical significance of PDUS in TTJ and peroneal tendons in RA patients. Impaired functional activity as represented by higher HAQ and FFI scores was highly significantly associated to pathologies in TTJ, STJ, TNJ, AT, RCB, and PF; see Table 1. <h3>Conclusion</h3> Asymptomatic RA ankles exhibited higher number of US alterations in comparison to healthy individuals and significantly impaired the functional status of patients with RA. Foot and ankle joints should be considered for future scores in assessing disease activity and follow-up. <h3>References</h3> [1]<b>Șerban, O., et al</b> Medical ultrasonography, 21, 175-182. [2]<b>Bruyn, G. A., et al</b> JRheum, 46, 351-359. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB0680 THE EFFECT OF DEPRESSION, ANXIETY, AND FIBROMYALGIA ON SEXUAL DYSFUNCTION IN FEMALE PATIENTS WITH SJÖGREN’S SYNDROME
Authors: S. M. Türk, D. Karataş, N. Erdik, G. Yavuzbilge, A. Karakurt, S. B. Acikgoz, Z. Öztürk, C. Arslantürk Güneysu, E. Gönüllü, Y. Türk
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Sjogren's Syndrome is a systemic autoimmune disease that mainly affects the exocrine glands.<sup>1</sup> The most common clinical symptoms of Sjogren's syndrome are dry mouth and eyes. Vaginal dryness and dyspareunia may be seen in the disease, as the female genital mucosa is also affected.<sup>2</sup> <h3>Objectives</h3> To compare the results by using the female sexual function scale in patients with Sjögren's Syndrome with and without depression, anxiety, and fibromyalgia and to evaluate the patients in terms of sexual dysfunction. <h3>Methods</h3> Twenty-five female patients diagnosed with Sjögren's Syndrome, according to the 2016 ACR-EULAR criteria, followed in the Internal Medicine, Rheumatology Clinic of Sakarya University Faculty of Medicine, were included in the study after their consent was obtained. Beck Depression Inventory, Beck Anxiety Inventory, and Female Sexual Function Scale were administered simultaneously to the patients. The presence of fibromyalgia was evaluated according to the 2016 Modified ACR diagnostic criteria. The relationship between depression, anxiety scale scores, the presence of fibromyalgia, and female sexual function was investigated. <h3>Results</h3> The mean age of the patients was 49±8.1 years, and the median duration of the disease was four years. 15 (60%) patients were primary school graduates, 2 (8%) patients were secondary school graduates, 4 (16%) patients were high school graduates, and 4 (16%) patients were university graduates. 11 (44%) of the patients were in menopause. Sexual dysfunction was found in 21 (84%) patients diagnosed with Sjögren's Syndrome. There was no statistically significant difference in sexual function scale scores between those with and without menopause. No statistical difference was found in disease duration, age, and scale scores in the presence of fibromyalgia. Sexual dysfunction was more pronounced in those with depression and anxiety (p=0.003; p=0.045, respectively) (Table 1). <h3>Conclusion</h3> Depression and anxiety cause lower sexual function scores in female patients diagnosed with Sjogren's syndrome. The effect of fibromyalgia has not been demonstrated, but due to the limited number of patients, studies with a larger population will be more enlightening. <h3>References</h3> [1]Priori R, Minniti A, Derme M, Antonazzo B, Brancatisano F, Ghirini S, et al. Quality of sexual life in women with primary Sjögren Syndrome. J Rheumatol. 2015 Aug;42(8):1427-31. doi:10.3899/jrheum.141475 [2]Piccioni MG, Merlino L, Deroma M, Del Prete F, Tabacco S, Monti M, Benedetti Panici P. The impact of primary Sjogren's syndrome on female sexual function. Minerva Ginecol. 2020 Feb;72(1):50-54. DOI: 10.23736/S0026-4784.20.04494-9. <h3>Disclosure of Interests</h3> None declared