tbuckley/cabot-search huggingface dataset:
Adverse effects and pyrogenic reactions during hemodialysis
Authors: V. E. Pollak
Journal: JAMA (1988)

By December 1986, more than 90 000 patients with end-stage renal disease (ESRD) underwent chronic dialysis in the United States. Two recent Centers for Disease Control (CDC) studies of adverse effects in this population reported in this issue of<i>JAMA</i><sup>1,2</sup>are seemingly addressed to nephrologists but may have interest for a wider audience. National funding to support ESRD patient care began with legislation and regulation in 1973 and 1974. Reports on this publicly funded program were to be made available to Congress, and quality of care was to be monitored by the Secretary of Health and Human Services. The framework to realize these objectives developed through cooperation of treatment providers, statutory ESRD Networks (whose function includes monitoring quality of patient care), the Health Care Financing Administration, and the National Institutes of Health. It is now possible to monitor quality continuously for a large program. Much information exists on patients
Erratum: ATS/ERS Statement on Pulmonary Rehabilitation
Authors: May Hua, P Craig Blinderman, M Wunsch
Journal: American Journal of Respiratory and Critical Care Medicine (2014)

We thank Dr. Lamas and colleagues for their comments related to our article on estimating palliative care needs in critically ill patients (1).We agree that integrative models of palliative care in intensive care units (ICUs) certainly deserve further study and attention.This method of delivering palliative care is essential not only because there is a shortage of fellowship-trained palliative care specialists to meet these needs but also as a matter of professional integrity for critical care providers to be able to have the competencies to treat pain and symptoms common in this population, facilitate goals-of-care conversations, and provide high-quality end-of-life care for patients who die in the ICU.An ongoing challenge is how to best allocate specialized palliative care.The role of specialized palliative care is likely to change depending on the practice setting.For example, in ICUs with an open staffing model, patients may not have a primary critical care provider who is concerned with the provision of adequate palliative care, and palliative care consultants may be needed to perform a needs assessment; in closed units with adequate training, palliative care consultation may be reserved for only the most challenging cases: difficult-to-manage symptoms, complex decision making, or conflict resolution.As with any other consultation service, the amount of specialist involvement that is required inherently depends on the services that can be provided by the primary team.Adequate delivery of palliative care to critically ill patients should be a high priority, and figuring out how to best meet these needs will require buy-in and cooperation from ICU clinicians, palliative care specialists, patients' primary physicians, and hospital administrators.It is imperative that we collaborate together, and, as Dr. Lamas and colleagues point out, study interventions, to create best practices and models that allow us to reach this common goal.
AGREEMENTS NOT TO PRACTICE MEDICINE.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lark-and-Elephant Pie Meets Humble Pie
Journal: Annals of Internal Medicine (1993)

Letters15 February 1993Lark-and-Elephant Pie Meets Humble PieThe EditorsThe EditorsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-4-199302150-00034 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Try as we might, we still make mistakes, usually when it involves friends and famous people. Sorry, Drummond! Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 1993Volume 118, Issue 4Page: 320 ePublished: 15 August 2000 Issue Published: 15 February 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Effects of Insulin on Hepatic Glucose Metabolism and Glucose Utilization by Tissues
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Medical Society
Authors: James C. McCann
Journal: New England Journal of Medicine (1945)

SUBCOMMITTEE ON MEDICAL ECONOMICS COMMITTEE ON POSTWAR PLANNINGA meeting of the Subcommittee on Medical Economics, Committee on Postwar Planning, was held on May 29, 1945. Besides the members of the subcommittee, Drs. Nathaniel W. Faxon and James C. McCann were present by invitation.The advantages and disadvantages of the plan for the postpayment of medical fees (Blue Triangle) were discussed. It was decided to postpone a detailed discussion of this subject until a later meeting, at which time one or more men who had been active in the study and organization of this plan would be asked to meet . . .
THE FEDERAL CHILDREN’S BUREAU AND ITS FIRST DIRECTOR
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sequencing the genome of hope.
Authors: Anna K. Ferguson, Evan J. Lipson
Journal: Journal of Clinical Oncology (2014)

e20574 Background: Hope is widely regarded as essential to the emotional health of cancer pts, yet remains under-studied. We sought to explore the concept of hope and develop a webcast-style teaching module to educate caregivers about the importance of hope in optimizing oncology care. Methods: We audio recorded interviews with current patients. Questions focused on what hope means to them, the role it plays in their ability to manage their illness, and ways in which they felt oncology providers could engender hope and positively impact their experience. We also interviewed oncology providers, including physicians, nurses, and social workers. Questions focused on the role that they feel hope plays for their pts, whether or not they have ever received training in how to discuss hope, and tools they currently use to discuss hope with their pts. Common themes were extracted and analyzed to form the backbone of a teaching module. Results: A total of 24 volunteers were enrolled in an IRB approved protocol. Half of the subjects were pts and the other half were oncology providers (n = 6 physicians, 3 nurses, 3 social workers). Hope emerged as a critical element to good quality of life in 12/12 (100%) pts.. The overwhelming majority (11/12, 92%) further expressed that feeling “well cared for” as well as receiving clear, honest information about their disease greatly increased their hopefulness. Hope also was recognized as essential to pts’ wellness and ability to manage their illness by all 12 (100%) of the providers. Although all providers recognized hope as essential to their pts, only the social workers reported that they had received some level of training in how to discuss hope,while the physicians and nurses felt that they had received little to no training. All providers expressed desire to contribute positively to their pts’ sense of hope. Conclusions: Both pts and providers view hope as a vital element in how oncology pts manage their illness. This point of connection between providers and pts offers a mechanism to enhance the pts'overall experience with cancer, yet most providers have little to no training in how to discuss hope. Development of a web-based education module is underway to increase awareness of the importance of hope and teach providers strategies to better engage with their pts on the subject of hope.
A Phase 1/2 Multi-Center, Randomized, Open Label Dose Escalation Study to Determine the Maximum Tolerated Dose, Safety, and Efficacy of Pomalidomide Alone or In Combination with Low-Dose Dexamethasone In Patients with Relapsed and Refractory Multiple Myeloma Who Have Received Prior Treatment That Includes Lenalidomide and Bortezomib
Authors: Paul G Richardson, David Siegel, Rachid Baz, Susan L. Kelley, Nikhil C. Munshi, Daniel Sullivan, Melissa Alsina, Deborah Doss, Laura McBride, Gail Larkins, Maria Lizza, Xin Yu, Mohamed Zaki, Christian J. Jacques, Kenneth C. Anderson
Journal: Blood (2010)
THE PHILADELPHIA SEMI-CENTENNIAL MEETING.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Streptococcal Pharyngitis
Authors: Marvin S. Krober
Journal: JAMA (1985)

Forty-four children with a clinical diagnosis of streptococcal pharyngitis had throat cultures performed at the initial evaluation and were assigned by randomization to receive either oral penicillin or a placebo for 72 hours. The treating physician, who remained blind to the treatment regimen, recorded the child's temperature and assessed the presence and severity of other signs and symptoms initially and at 24, 48, and 72 hours. The throat culture was positive for group A β-hemolytic streptococci in 26 (59%) of the initial study group, and most of these children developed a fourfold or greater titer rise in antistreptococcal antibodies in their serum, confirming the diagnosis of streptococcal pharyngitis. Statistically significant clinical improvement was observed in the group of 11 children who were later shown to have been taking penicillin compared with the group of 15 who had taken the placebo. Significant differences in the presence and degree of fever and severity of symptoms persisted in the placebo-treated group for 48 hours. We conclude that early penicillin treatment of children with streptococcal pharyngitis significantly alters the acute clinical course of the disease. (<i>JAMA</i>1985;253:1271-1274)
Personal PM2.5 exposure and markers of oxidative stress in blood.
Authors: Mette Sørensen, Bahram Daneshvar, Max Hansen, Lars O Dragsted, Ole Hertel, Lisbeth Knudsen, Steffen Loft
Journal: Environmental Health Perspectives (2003)

Ambient particulate air pollution assessed as outdoor concentrations of particulate matter less than or equal to 2.5 micro m in diameter (PM(2.5)) in urban background has been associated with cardiovascular diseases at the population level. However, the significance of individual exposure and the involved mechanisms remain uncertain. We measured personal PM(2.5) and carbon black exposure in 50 students four times in 1 year and analyzed blood samples for markers of protein and lipid oxidation, for red blood cell (RBC) and platelet counts, and for concentrations of hemoglobin and fibrinogen. We analyzed protein oxidation in terms of gamma-glutamyl semialdehyde in hemoglobin (HBGGS) and 2-aminoadipic semialdehyde in hemoglobin (HBAAS) and plasma proteins (PLAAS), and lipid peroxidation was measured as malondialdehyde (MDA) in plasma. Median exposures were 16.1 micro g/m(3) for personal PM(2.5) exposure, 9.2 micro g/m(3) for background PM(2.5) concentration, and 8.1 X 10(-6)/m for personal carbon black exposure. Personal carbon black exposure and PLAAS concentration were positively associated (p < 0.01), whereas an association between personal PM(2.5) exposure and PLAAS was only of borderline significance (p = 0.061). A 3.7% increase in MDA concentrations per 10 micro g/m(3) increase in personal PM(2.5) exposure was found for women (p < 0.05), whereas there was no significant relationship for the men. Similarly, positive associations between personal PM(2.5)exposure and both RBC and hemoglobin concentrations were found only in women (p < 0.01). There were no significant relationships between background PM(2.5) concentration and any of the biomarkers. This suggests that exposure to particles in moderate concentrations can induce oxidative stress and increase RBCs in peripheral blood. Personal exposure appears more closely related to these biomarkers potentially related to cardiovascular disease than is ambient PM(2.5) background concentrations.
Leads from the MMWR. Immunization of children infected with human T-lymphotropic virus type III/lymphadenopathy-associated virus
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The smaller the cancer, the bigger the operation? Rationale of small operations for small tumors and large operations for large tumors
Authors: G. Crile
Journal: JAMA (1967)

For many years, surgeons have accepted the old maxim that the smaller the cancer, the bigger the operation should be. It has been said that the chances of cure are best when a small cancer, without apparent metastasis, is treated by wide removal of the primary tumor and the lymphatics and lymph nodes that drain it. On the other hand, many surgeons believe that patients with advanced cancers that have metastasized extensively to nodes often should be treated palliatively by relatively small operations. There is mounting evidence from the field of immunology that the old adages are false and their opposites may be true. It now seems that removal of uninvolved regional nodes that drain small tumors may lower the patient's immunologic resistance to the implantation and growth of distant metastases. On the other hand, radical removal of large cancers and the nodes to which they have metastasized may prolong
High serum lactate dehydrogenase level predicts short survival after vincristine–doxorubicin–dexamethasone (VAD) salvage for refractory multiple myeloma
Authors: Miyuki Suguro, Yshinobu Kanda, Rie Yamamoto, Aki Chizuka, Tamae Hamaki, Tomohiro Matsuyama, Naoki Takezako, Akiyoshi Miwa, Atsushi Togawa
Journal: American Journal of Hematology (2000)

We evaluated possible prognostic factors just before salvage therapy with vincristine, doxorubicin, and dexamethasone (VAD) for 36 patients with refractory multiple myeloma. The median duration from diagnosis to the first VAD salvage was 14 months (range 2–76 months). Among parameters that have been shown to be associated with poor survival, a high serum lactate dehydrogenase (LDH) level was the sole significant predictor of survival. The median survival of patients with high LDH levels was 4 months, whereas that of patients with low LDH levels was 20 months. A multivariate analysis identified high LDH and high age as independent prognostic factors. More aggressive therapies might be indicated for high-LDH patients with refractory myeloma. Am. J. Hematol. 65:132–135, 2000. © 2000 Wiley-Liss, Inc.
Koch's Method in Pulmonary Tuberculosis..
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exposure to Heterocyclic Amines
Authors: Keiji Wakabayashi, Hirofumi Ushiyama, Makoto Takahashi, Haruo Nukaya, Seon-Bong Kim, Misako Hirose, Masako Ochiai, Takashi Sugimura, Minako Nagao
Journal: Environmental Health Perspectives (1993)

Many mutagenic heterocyclic amines (HAs) have been isolated from cooked foods and pyrolysates of amino acids and proteins, and the carcinogenicity of 10 of these HAs in rodents and of 1 in monkeys has been reported. Quantification of these carcinogenic HAs in various kinds of cooked foods indicated that the level of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) was highest (0.56-69.2 ng/g), that of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) was second highest (0.64-6.44 ng/g), and those of other HAs were 0.03-2.50 ng/g. Heterocyclic amines were found in urine samples of 10 healthy volunteers consuming a normal diet, but HAs were not detectable in urine samples of three patients receiving parenteral alimentation. These results strongly suggest that humans are continuously exposed to HAs derived from food in the normal diet. Based on quantitative data on the levels of HAs in cooked foods and urine samples, the daily exposures to PhIP and MeIQx were estimated to be 0.1-13.8 micrograms and 0.2-2.6 micrograms per person, respectively. These levels of carcinogenic HAs are in the same range as those of other carcinogens such as N-nitrosodimethylamine and benzo[a]pyrene to which humans are exposed.