tbuckley/cabot-search huggingface dataset:
Phase I study of oral suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, in patients (pts) with advanced leukemias or myelodysplastic syndromes (MDS)
Authors: G. Garcia-Manero, J.-P. Issa, J. Cortes, C. Koller, S. O'brien, E. Estey, A. A. Canalli, J. Chiao, V. Richon, H. Kantarjian
Journal: Journal of Clinical Oncology (2004)

3027 Background: SAHA is a histone deacetylase inhibitor with in vitro antileukemia activity. Methods: We present results of a phase I study in pts with leukemia/MDS given SAHA orally three times a day (TID) x 14 consecutive days every 21days. The TID schedule was developed to induce continuous histone hyperacetylation for 14 days. The initial dose level was 100 mg po TID with dose escalation in increments of 50 mg TID, using a 3+3 design. Eligibility included: relapsed/refractory leukemia/MDS, or untreated disease if pt not willing to proceed with standard therapy, preserved organ function and performance status. Results: 15 pts have been treated and are evaluable for toxicity. At dose level 1, 2 pts with AML and 1 CMML. At level 2, 1 pt with AML, 1 with ALL and 1 with CLL. At level 3, 4 with AML, 1 with MDS and 1 with ALL, at level 4, 2 with AML and 1 with CML. Median age is 71 years; median number of prior therapies 2. Dose level 3 was expanded from 3 to 6 pts, to better assess toxicity. No pt has experienced grade 3- 4 toxicity or death related to SAHA. The most commonly reported adverse events, regardless of causality, are nausea, vomiting, diarrhea, anorexia, headache, fatigue, dyspepsia, that resolved during the week of rest. Lab abnormalities included pancytopenia, hyperglycemia, hypokalemia, hypocalcemia, hypophosphatemia. Histone hyperacetylation was detected in pts treated at all dose levels. On dose level 1, one pt with AML achieved hematological improvement (marrow blasts less than 5%, ANC > 1x 109k/UL, but no recovery of platelets) and progressed in the marrow after 6 courses. On dose level 2, one CLL pt had reduction in the size of lymph nodes. On dose level 3, one elderly pt with untreated AML achieved a complete remission after 2 courses of therapy, now maintained after 4; two additional AML pts and one MDS pt had a decrease in marrow blasts to less than 10% without peripheral blood recovery. Conclusions: These results indicate that single agent SAHA is well tolerated up to doses of 250 mg po TID x 14 days every 21 days and has promising activity in pts with AML/MDS. Dose escalation continues. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Aton Pharma Aton Pharma Aton Pharma
Holes in the Swiss Health Care System
Authors: Isabelle Peytremann Bridevaux, Brigitte Santos-Eggimann
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Combined Impact of Health Behaviours and Mortality in Men and Women: The EPIC-Norfolk Prospective Population Study
Authors: Kay-Tee Khaw, Nicholas Wareham, Sheila Bingham, Ailsa Welch, Robert Luben, Nicholas Day
Journal: PLoS Medicine (2008)

An error was made with the cutoff vitamin C level reported in this paper (>50 mmol/l).The units should have been given in micromoles per litre, not millimoles per litre, for vitamin C. Throughout the manuscript, wherever >50 mmol/l is given as the cutoff, >50 micromol/l is the correct vitamin C level that should have been reported.
More Notes on Recent ANNALS Themes
Authors: E. J. H.
Journal: Annals of Internal Medicine (1968)

Editorial Notes1 October 1968More Notes on Recent ANNALS ThemesE. J. H.E. J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-69-4-843 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDEATH AND DYINGIn our July issue Dr. Charles D. Aring (1) wrote on the physician's view of death and how he can prepare himself for better care of the dying patient. This theme is treated with other variations in a recent paper (2) from Australia, "Emotional Reactions Associated with Death." Its author, Dr. John Ellard, concentrates on attitudes of man to his inevitable but yet distant death, the effect of death on surviving family, and the patient's experience of dying. Dr. Ellard closes his paper with advice that should be especially helpful to the house officer as he forms...References1. ARING CD: Intimations of mortality: an appreciation of death and dying. Ann. Intern. Med. 69: 137, 1968. LinkGoogle Scholar2. ELLARD J: Emotional reactions associated with death. Med. J. Aust. 1: 979, 1968. CrossrefMedlineGoogle Scholar3. KOCH-WESER J: Coumarin necrosis. Ann. Intern. Med. 68: 1365, 1968. LinkGoogle Scholar4. LARCANBERTRANDRICHONCALAMAI APJM: [Necrotic and bullous skin complications due to Coumarin anticoagulants.] (Fr.) Presse Med. 76: 1217, 1968. MedlineGoogle Scholar5. SCHIFFKERN BLAB: Cutaneous reactions to anticoagulants. Arch. Derm. (Chicago) 98: 136, 1968. CrossrefMedlineGoogle Scholar6. HUTH EJ: E. H. Derrick, describer of Q fever (editorial). Ann. Intern. Med. 68: 959, 1968. LinkGoogle Scholar7. ITO T: An outline of research history of the Tsutsugamushi disease in Niigata Prefecture of Japan. Acta Med. Biol. (Niigata) 15 (suppl.): 1, 1967. MedlineGoogle Scholar8. SASA M: A historical review on the progress in studies of Tsutsugamushi in Japan. Ibid., p. 9. Google Scholar9. What are you doing about cigarette smoking (editorial)? Ann. Intern. Med. 69: 163, 1968. LinkGoogle Scholar10. BRETTBENJAMIN GZB: Smoking habits of men employed in industry, and mortality. Brit. Med. J. 3: 82, 1968. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1968Volume 69, Issue 4Page: 843-844KeywordsEmotions Issue Published: 1 October 1968 PDF downloadLoading ...
April 25, 2001
Journal: JAMA (2001)

Laurent Mandelbrot, MD; Aline Landreau-Mascaro, MS; Claire Rekacewicz, MD; Alain Berrebi, MD; Jean Louis Bénifla, MD; Marianne Burgard, PhD; Eric Lachassine, MD; Béatrice Barret, MD; Marie-Laure Chaix, PhD; André Bongain, MD; Nicole Ciraru-Vigneron, MD; Catherine Crenn-Hébert, MD; Jean-François Delfraissy, MD; Christine Rouzioux, PhD; Marie-Jeanne Mayaux, BA; Stéphane Blanche, MD; for the Agence Nationale de Recherches sur le SIDA (ANRS) 075 Study Group
Wilderness Medicine
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Penicillin-resistaant pneumococci.
Journal: BMJ (1971)

valuable for burns surgery; as well as preventing hypotension, it may make a difficult endotracheal intubation un- necessary.'2It is also a good choice for many minor paedi- atric operations and procedures, such as intravenous cannu- lation on an uncooperative child, and for certain radiological investigations.Finally, it may be especially useful in ill patients for the induction of anaesthesia or for short opera- tions on the body surface.Ketamine is easy to administer.In countries in which there are few skilled anaesthetists there will be a temptation to use ketamine widely without an anaesthetist.'3Though ketamine has a considerable margin of safety, occasionally the airway becomes obstructed.There can be respiratory depression.A letter in this issue (p.709) reports that, as with any other anaesthetic, the untoward can occur with little or no warning.Thus the use of ketamine does not, in any respect, reduce the need for continuous vigilance and skilled care.
Efficacy of methylprednisolone in acute spinal cord injury
Authors: M. B. Bracken
Journal: JAMA (1984)

A multicenter double-blind randomized trial was conducted to examine the efficacy of a high dose of methylprednisolone (1,000-mg bolus and daily thereafter for ten days) compared with a standard dose (100-mg bolus and daily thereafter for ten days) in 330 patients with acute spinal cord injury. No difference in neurological recovery of motor function or pinprick and light touch sensation was observed between the two treatment groups six weeks and six months after injury. The lack of a treatment effect was independent of the severity of the initial lesion or the time from injury to starting treatment. Although not statistically significant, early case fatality was greater in the high-dose protocol (relative risk of 3.1 and 1.9, ≤ 14 and 15 to 28 days after injury, respectively) but not from 29 to 210 days after injury. Wound infections of both trauma and operative sites were more prevalent in the high-dose regimen (relative risk of 3.6). (<i>JAMA</i>1984;251:45-52)
OPHTHALMIA AND DIET
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Informed Consent
Authors: Ralph J. Alfidi
Journal: JAMA (1971)

This study was made to determine the reactions of patients to a general disclosure of complications which might result from angiographic procedures. To minimize bias and insure uniformity a form letter and questionnaire were chosen to impart this information. The results of this study indicate that the majority of patients referred to the Cleveland Clinic desired this information. I am convinced of the value of informed consent, for the benefit of both the patient and his physician.
Participation in School Physical Education and Selected Dietary Patterns Among High School Students—United States, 1991
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Direct Action through the Sertoli Cells Is Essential for Androgen Stimulation of Spermatogenesis
Authors: P. J. O'Shaughnessy, G. Verhoeven, K. De Gendt, A. Monteiro, M. H. Abel
Journal: Endocrine Reviews (2010)

ABSTRACT Androgens act to stimulate spermatogenesis through androgen receptors (ARs) on the Sertoli cells and peritubular myoid cells. Specific ablation of the AR in either cell type will cause a severe disruption of spermatogenesis. To determine whether androgens can stimulate spermatogenesis through direct action on the peritubular myoid cells alone or whether action on the Sertoli cells is essential, we crossed hypogonadal (hpg) mice that lack gonadotrophins and intratesticular androgen with mice lacking ARs either ubiquitously (ARKO) or specifically on the Sertoli cells (SCARKO). These hpg.ARKO and hpg.SCARKO mice were treated with testosterone (T) or dihydrotestosterone (DHT) for 7 d and testicular morphology and cell numbers assessed. Androgen treatment did not affect Sertoli cell numbers in any animal group. Both T and DHT increased numbers of spermatogonia and spermatocytes in hpg mice, but DHT has no effect on germ cell numbers in hpg.SCARKO and hpg.ARKO mice. T increased germ cell numbers in hpg.SCARKO and hpg.ARKO mice, but this was associated with stimulation of FSH release. Results show that androgen stimulation of spermatogenesis requires direct androgen action on the Sertoli cells.
Kidney Diseases.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disasters, flying squads, and immediate care.
Journal: BMJ (1979)

Why should a death certificate for "general peritonitis due to pyosalpinx" be referred to the coroner by the registrar of births and deaths ?Assuming there were no other relevant circumstances, it seems quite obscure why this cause of death should be unacceptable to the registrar of births and deaths and necessitate referral to the coroner.As it stands, it is a perfectly natural cause of death and inquiries of another local registrar suggest that it would not have been so reported at that office.A referral would be made only if the peritonitis followed recent surgical intervention, which could have been a factor in the peritonitis and subsequent death.A less unlikely factor would be if there was any possibility that the condition had followed an abortion that was anything other than spontaneous.
Gastric histoplasmosis. A case report
Authors: H. L. Nudelman
Journal: JAMA (1966)

HISTOPLASMOSIS may involve many organ systems of the body, including the gastrointestinal tract,<sup>1</sup>but lesions in the stomach are rare. This communication describes what we believe to be the first published case of gastric histoplasmosis mimicking carcinoma of the stomach. <h3>Report of a Case</h3> A 66-year-old white man (8-0-60-00314) was admitted to Barnes Hospital on June 21, 1960, for radical neck dissection after a malignant melanoma of the right subauricular area had been excised when he was an outpatient. Surgery was postponed because of fever, the temperature fluctuating between 98.6 and 104 F (37 and 40 C). The temperature elevations usually occurred in late afternoon and early evening. Findings of the physical examination were normal except for hepatomegaly, 2 to 3 cm below the right costal margin. X-rays of the chest demonstrated a right hilar mass with multiple small nodules in the right hilar area and left lower lobe,
Dilatation and evacuation procedures and second-trimester abortions. The role of physician skill and hospital setting
Authors: W. Cates
Journal: JAMA (1982)

Some clinicians have hesitated to perform dilatation and evacuation (D&amp;E) procedures at 13 weeks' gestation or later because D&amp;Es are more difficult to perform safely than suction-curettage procedures. Moreover, many clinicians still believe all second-trimester abortion procedures should be performed in a hospital. To evaluate these concerns, we analyzed 24,664 abortions performed between 1973 and 1978 by four physicians associated with a large outpatient abortion facility; 3,711 (15%) of the abortions were second-trimester procedures. Dilatation and evacuation was associated with a lower rate of serious complications per 100 procedures (0.23) than instillation of either dinoprost (prostaglandin F<sub>2α</sub>) (1.28) or hypertonic saline (2.26). In addition, D&amp;E had lower rates for most other specific complications. We conclude that D&amp;E, while requiring more operator skill than earlier suction-curettage procedures, can be learned by gynecologists familiar with suction-curettage, can be performed more safely than the alternative instillation procedures, and can be safely practiced in selected ambulatory settings. (<i>JAMA</i>1982;248:559-563)
Role of cesarean delivery in preventing neonatal herpes virus infection
Authors: R. S. Gibbs
Journal: JAMA (1993)

For the past 30 years our incomplete understanding of perinatally acquired herpes infections has resulted in controversy. The lack of adequate data led to practice recommendations that have recently been changed regarding patients with recurrent herpes infection.<sup>1,2</sup>We now recognize that most cases of neonatal herpes infections are not preventable with current approaches.<sup>3</sup> From the late 1960s until the mid 1980s, the practice recommendation to prevent neonatal herpes consisted of performing weekly herpes cultures of the lower genital tract in women with a previous history of herpes followed by a cesarean delivery if lesions were present or if cultures were positive at the time of delivery. This practice recommendation was based on a small series of retrospectively gathered cases<sup>4</sup>and was generated without detailed knowledge of the natural history of genital or neonatal herpes (eg, differences between primary episode, nonprimary first episode, and recurrent episodes; and rates
Coronary Blockage and Valve Replacement Views Presented
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
19. Targeted nanoparticles for smarter cancer therapy
Authors: Nicholas A. Peppas, Ruth Duncan, Gary E. Wnek, Allan S. Hoffman, Guang Hui Gao, Sung Wan Kim, Doo Sung Lee, Michael Hadjiargyrou, Elka Touitou, Denize Ainbinder, Russell Mumper, Alain Rolland, Takuro Niidome, Vinod Labhasetwar, Shi Liu, Guangyuan Zhou, Yubin Huang, Zhigang Xie, Xiabin Jing, Noemi Csaba
Journal: Journal of Controlled Release (2014)