tbuckley/cabot-search huggingface dataset:
Comparative Effects of Horse, Calf, and Fetal Serums on Chromosomal Characteristics and Neoplastic Conversion of Mouse Embryo Cells &lt;italic&gt;In Vitro&lt;/italic&gt;
Authors: John T. Mitchell, William F. Andresen, Virginia J. Evans
Journal: JNCI Journal of the National Cancer Institute (1969)

The effect of different adult and fetal serums on the chromosomal characteristics and neoplastic conversion of C3H/HeN mouse embryo cells grown in vitro was studied. Cell lines were established in chemically defined medium NCTC 135 with 10% v/v horse, calf, fetal calf, early fetal calf, or fetal horse serum. Implantations into isologous hosts and chromosome analyses were made periodically up to 260 days in vitro. By 235 days, cells in all serum supplements except fetal calf produced transplantable fibrosarcomas. There was little time difference or incidence in the neoplastic conversion of cells cultured in horse, calf, early fetal, or fetal horse serum. Cells in fetal calf and fetal horse serum from animals of comparable gestation did not undergo neoplastic conversion at the same age in vitro. Cell lines cultured in horse or calf serum shifted from diploidy more rapidly than those supplemented with fetal serums, which showed a slower and more erratic shift. By 260 days in vitro all cell lines in the five serum supplements had become heteroploid and possessed mixed modes. The occurrence of specific chromosome aberrations could not be correlated with any of the five serum supplements nor with the onset of neoplastic conversion. Markers seemed to be more closely associated with adaptations to in vitro conditions than with tumor production. Cells in fetal calf serum again showed a less rapid shift away from diploidy, fewer structural alterations, and a delay in the onset of neoplastic conversion when compared with the other four serums. Fetal calf serum may influence the selection of cell variants best adapted for continuous growth in vitro, resulting in the gradual accumulation of cells altered in chromosome complement, while the remaining four serums effect this karyotypic alteration at a more rapid rate.
Ultrastructural and morphometrical evaluations on normal human dermal connective tissue - the influence of age, sex and body region
Authors: D. QUAGLINO, G. BERGAMINI, F. BORALDI, I. PASQUALI RONCHETTI
Journal: British Journal of Dermatology (1996)

In order to give detailed structural and quantitative evaluations for some of the most important dermal constituents such as collagen, elastic fibres and mesenchymal cells, and for the non–structured extracellular matrix, we performed ultrastructural investigations on dermal biopsies from 50 healthy Caucasian subjects aged from 6 fetal months to 83 years. Striking changes were observed, mainly in the perinatal period, for collagen, elastin and mesenchymal cells and. after 50 years of age, for collagen and elaslin. Only slight or negligible differences were noted between males and females and in skin specimens taken from different parts of the body but similarly exposed to environmental factors (i.e. UV radiation). Modifications of the non–structured extracellular matrix appeared to be the consequence of changes affecting the other components. The results, therefore. emphasize the importance of the ageing factor in connective tissue metabolism and give further information on both qualitative and quantitative characteristics of normal human dermis.
Filling Defect in the Urinary Bladder
Authors: Jack M. Korsower
Journal: JAMA (1975)

<h3>Common</h3> Blood clot Calculus Instrument (eg, Foley catheter) Neoplasm, intrinsic or invasive Polyp Prostatic enlargement Ureterocele, simple or ectopic <h3>Uncommon</h3> Endometriosis Foreign body Fungus ball (eg, monilia) Hematoma, intramural Hydatid cyst Infection, fistula, abscess (eg, from Crohn disease or diverticulitis) Postoperative Schistosomiasis hematobium (granuloma or polyp) <h3>Diagnosis</h3> Prostatic hypertrophy appearing as an intravesical mass. <h3>Comment</h3> An elderly man had a typical history of prostatism and bladder outlet obstruction. Rectal examination showed no abnormalities, but a large intramural mass was noted in the bladder neck on cystoscopy. The intravenous pyelogram shows a smooth, round filling defect within the bladder in an inferior midline location. It appeared to be in the lumen, but elevation of the distal ends of the ureters and trigone indicates an intramural or extrinsic lesion, since a purely intraluminal mass would not
Usefulness of Oral Mucosal Transudate for HIV Antibody Testing
Authors: Prudencio Martinez
Journal: JAMA (1997)

<h3>To the Editor.</h3> —We read the article by Ms Gallo and associates<sup>1</sup>about the new oral specimen collection device for HIV testing with great interest. We would like to contribute our experience in diagnosis of HIV infection using fluids other than serum (ie, OMT and urine). We analyzed 185 paired serum, gingivocrevicular transudate, and urine samples from individuals infected with HIV-1 (69 of whom were Centers for Disease Control and Prevention [CDC] stage II, 15 CDC stage III, and 30 CDC stage IV) and 71 noninfected individuals, blood donors from the hematology service of our hospital. We used an oral device consisting of a cylinder of cotton wool without preservative (Salivette, Sarstedt, Leicester, United Kingdom). Sample preservation was ensured by refrigeration. Individuals participating in the study were informed about the importance of proper pad placement in the gingivocrevicular fold and also that the pad should be removed from the mouth when it
The Vermiform Appendix and Its Diseases.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Physician and the Handicapped Child
Authors: Marc A. Forman
Journal: JAMA (1982)

WITHIN medicine, problems of care are usually discussed in terms of data gathering, treatment strategies, and outcome evaluation. Scientific advances notwithstanding, medicine remains a profession that is highly social in context and transactional in approach. Care involves attitudes, expectations, and values as much as it does instruments, surgery, and drugs. In working with children, and especially handicapped children, there are many dilemmas of care that the physician confronts. These are often described as "emotional issues" presented by the handicapped child<sup>1</sup>and his family<sup>2</sup>(eg, problems of overprotection, denial, rejection, overcompensation, depression, and loss of self-image). These problems generally relate to the family and not to the physician. However, there are also social and transactional issues that affect the physician as well, and these have received less attention. We offer the following as several examples of such dilemmas. <h3>The Toleration of Uncertainty</h3> The physician is trained to do. Medicine attracts
American Indian Medicine: Paternalism and Pluralism
Authors: Jean E. Smith
Journal: JAMA (1986)

<h3>To the Editor.—</h3> I wonder if anyone else gets tired of hearing about the noble Native American culture and how beautiful, pure, and in harmony with the world it was until the rude, crude, modern "American" culture destroyed it. Your recent article on American Indian medicine<sup>1</sup>approaches the subject in the usual "noble Indian/wicked white man" way. Having worked on an Indian reservation associated with public health for two years, I am by no means an expert on the subject; but neither am I ignorant of the many facets of the problem. It is of primary importance to understand that there is no one Native American culture. To group, therefore, a bunch of doctors who have at least one-eighth Indian blood together and make them represent all the Indian tribes is naive and dooms their efforts to improve the lot of Indians. The tremendous diversity in cultural backgrounds of different
Hypoxic responses in infants
Authors: C. West, N. Pace, S. Niermeyer, L. G. Moore, M P W. Platt, P J Fleming, P S Blair, C E A Leach, J Golding, I Smith, P. Johnson, J. Savulescu, P B James, D. Southall, C Poets, L. O'Brien, V. Stebbens, K Parkins
Journal: BMJ (1998)

# Subjecting infants to low oxygen concentrations seems unethical {#article-title-2} EDITOR—The ethics of Parkins et al's study depend partly on whether there is any potential benefit to the infants from the experiment.1 If parents subject their infant to low oxygen concentrations in an aeroplane they take a risk which is balanced against the benefit of air travel. Unless there is some real prospect of identifying infants at risk and offering useful protection against the sudden infant death syndrome, it seems to me to be unethical to subject those infants to the risk of exposure to low oxygen concentration. The fact that some of the families had previously experinced the loss of a child may have increased the likelihood of compliance. This makes me even more worried about the ethics of the study. 1. ↵1. Parkins KJ, 2. Poets CF, 3. O'Brien LM, 4. Stebbens VA, 5. Southall DP .Effect of exposure to 15% oxygen on breathing patterns and oxygens aturation in infants: interventional study. [With commentary by J Savulescua nd V Hughes and authors' reply.]BMJ1998; 316:887–894(21 March.) [OpenUrl][1][Abstract/FREE Full Text][2] # Research should contain element of treatment {#article-title-4} EDITOR—Parkins et al and Hughes, the chairman of the local ethics research committee, in their reply to the commentary by Savulescu, repeat that the parents knew of the potential risks and gave consent.1 This does not justify the research. In the case of proxy consent the people—in this case the parents—vested with that power must use it reasonably. The law regarding the participation of children in non-therapeutic research is unclear. The most favourable suggestion, from the researchers' point of view, is that the validity of consent should be based on whether the parents are clearly not acting against the best interests of the child. Thus the amount of risk that the child is exposed to becomes relevant.2 According to the British Paediatric Association it would be unethical to submit child subjects to more than minimal risk when the research offers no or minimal benefit to them.3 The Institute of Medical Ethics has defined minimal as a risk of death of less than 1:1 000 000, a risk of major complications of less than 1:100 … [1]: {openurl}?query=rft.jtitle%253DBMJ%26rft.stitle%253DBMJ%26rft.issn%253D0007-1447%26rft.aulast%253DParkins%26rft.auinit1%253DK%2BJ%26rft.volume%253D316%26rft.issue%253D7135%26rft.spage%253D887%26rft.epage%253D894%26rft_id%253Dinfo%253Apmid%252F9552835%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=bmj&resid=316/7135/887&atom=%2Fbmj%2F317%2F7159%2F675.atom
Emphysematous Cholecystitis
Authors: L Freitas, G Do Carmo, L Caldeira, J Farto e Abreu, M Lélis, M Doroana
Journal: JAMA (1983)

Emphysematous cholecystitis (EC) is a rare and dramatic disease that requires prompt therapeutic procedures. The authors report a case of a 70-year-old-woman, admitted to the Intensive Care Unit for Infectious Diseases of the Santa Maria Hospital, with the diagnosis of EC. The literature on EC is also reviewed.
The Conscientious Objector
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Awards, Appointments, Announcements
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Awards, Appointments, Announcements Get access JNCI: Journal of the National Cancer Institute, Volume 83, Issue 5, 6 March 1991, Pages 327–328, https://doi.org/10.1093/jnci/83.5.327 Published: 06 March 1991
Применение дыхательных тестов с целью улучшения результатов лечения целиакии
Authors: Ye.Yu. Gubskaya, Yu.V. Chichula, L.M. Kupchik
Journal: GASTROENTEROLOGY (2014)

В статье приведены собственные данные исследования современных возможностей повышения эффективности лечения больных целиакией (n = 41). Все пациенты находились на аглиадиновой диете, тем не менее эффективность лечения расценивалась как неудовлетворительная. Благодаря использованию современных углеродных и водородных дыхательных тестов и диагностике синдрома чрезмерного бактериального роста, лактазной недостаточности и внешнесекреторной недостаточности поджелудочной железы, которые оказались причинами персистенции клинической симптоматики, были получены основания для их коррекции и достигнута полная ремиссия основного заболевания.
Universities and tobacco money
Authors: J. Powles, H. Kawane
Journal: BMJ (2001)

Two week rule for cancer referralsReducing waiting times from diagnosis to treatment might be more effectiveEditor-In their editorial on the two week rule for cancer referrals Jones et al discuss the fact that steps to meet the target for "urgent" referrals have led to a doubling of waiting time for "routine" cases. 1 This is exactly the result we would expect from our calculations modelling waiting times with a Monte Carlo model based on Poisson fluctuations in demand. 2 To sustain a waiting time below two weeks, capacity needs to exceed mean demand by approximately two patients a week for a wide range of values of mean demand.This applies to any appointment, including those for diagnostic and staging procedures, as well as for treatment.Applying this excess capacity to a subgroup of urgent referrals is inherently less efficient than applying it to reduce the waits for all patients.If a fast track for urgent referrals is created by transferring resources from routine cases, this is likely to lead to demand exceeding capacity for routine cases and hence to ever increasing waiting times.These calculations assume that variations are due to random fluctuations in a constant demand, which is an effective model for oncology referrals. 2There is some evidence from dermatology that reductions in waiting times lead to increase in demand, negating the benefit of increased resources. 3t might also apply to referrals for suspected cancer, in which case the extra capacity required will exceed our calculations.This effect should not apply to the number of cases of diagnosed cancer, which will be limited by the incidence of the disease.This suggests that resources may be more effectively targeted at reducing the waiting times from diagnosis to treatment than on reducing the time from referral by a general practitioner to diagnosis.
The Diagnosis and Treatment of Intussusception.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Evaluation of the Role and Clinical Contribution of New Cross Dental Therapists
Authors: R D Holt, J J Murray
Journal: Journal of the Royal Society of Medicine (1980)

The first dental therapists (previously called dental auxiliaries), started their training in 1960 and, by the end of 1976, 792 women had qualified after a two-year course. In the present study the role of all dental therapists was investigated by means of a postal survey. The clinical contribution made by these ancillaries was assessed by means of a retrospective analysis of clinic day sheets recorded by 55 dental therapists employed in the community dental services. It was found that dental therapists, in terms of their working pattern and family profile, are typical of women of their age and level of qualification in Britain. The return to work by therapists, after a break from practice because of family commitments, will depend mainly on the availability of posts, particularly part-time posts. Dental therapists provide treatment predominantly for younger children. Compared with previous studies, a noticeable increase in the clinical preventive care provided by therapists was observed.
Uterine Aspiration for Evacuation of the Pregnant Uterus
Authors: Crosby J. Eaton
Journal: JAMA (1969)

Uterine aspiration was employed in 200 pregnant patients with incomplete abortions, molar pregnancies, or to effect therapeutic abortion. In patients with incomplete abortion, the procedure was a complete one through the 12th week and was effective in reducing uterine size in the remainder. It was also effective for the evacuation of molar pregnancy and in therapeutic abortion. There were no complications in any of these patients attributable to uterine aspiration.
Chemical Pathology. Being a Discussion of General Pathology from the Standpoint of the Chemical Processes Involved.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Integrity of the permeability barrier regulates epidermal Langerhans cell density
Authors: E. PROKSCH, J. BRASCH, W. STERRY
Journal: British Journal of Dermatology (1996)

Summary Previous studies have shown that barrier requirements regulate epidermal liquid and DNA synthesis. In the present study, we examined the possibility that the integrity of the permeability barrier influences epidermal Langerhans cells involved with the immune response. Barrier disruption was achieved by treatment of human skin with acetone, sodium dodecylsulphate (SDS), or tape stripping, until a 10–20-fold increase in transepidermal water loss was achieved. Serial biopsies were performed 6–168 after treatment, and Langerhans cells were complexed with anti-CD1a (Leu6) or S-l00 antibodies, and visualized with an immunoperoxidase technique. Acetone treatment resulted in an increase in epidermal Langerhans cell density, reaching a maximum of 94% over control (P < 0.01) by 24 and 48 h post-treatment. Following SDS treatment or tape stripping, epidermal Langerhans cell density was increased by 100 and 175% (P < 0.01), respectively. There was a linear correlation between the degree of barrier disruption and the increase in epidermal Langerhans cell density. Studies with the Ki-S3 proliferation-associated nuclear antigen revealed a two- to threefold increase in epidermal proliferation after barrier disruption. The time curves of the increase in Langerhans cell density and the increase in epidermal proliferation were similar, suggesting that there was a coordinate regulation. In contrast with our previous studies employing patch test reactions to allergens or irritants, disruption of barrier function neither resulted in an increased dermal Langerhans cell density, nor influenced T lymphocytes (CD3+. Leu4+). Macrophages (KiM8+), ICAM-1 or ELAM-1 expression in the skin. In addition, barrier disruption did not result in either dermal inflammation or epidermal spongiosis. In summary these findings support our hypothesis that the permeability barrier influences epidermal Langerhans cell density, which is involved in maintaining an immunological barrier.
Electromyography in Collagen Disease
Authors: Robert P. Christopher
Journal: JAMA (1968)

Advances in electronics in the past 20 years have added many new capabilities to diagnostic medicine. Electromyography and motor and sensory nerve conduction studies are results of this progress. These studies have been found to be of value in the diagnosis and management of some of the collagen diseases and their complications. In myopathies, such as polymyositis and dermatomyositis, electromyography is useful in ascertaining the presence of primary muscle degeneration and can be of assistance in choosing a site for muscle biopsy. Motor and sensory nerve conduction studies provide an objective measure of peripheral nerve function and thereby enable the physician to delineate the presence of peripheral and entrapment neuropathies.