tbuckley/cabot-search huggingface dataset:
Tumor dissemination after radiofrequency ablation of hepatocellular carcinoma
Authors: Ilario de Sio, L. Castellano, V. De Girolamo, Scotto S. di Santolo, A. Marone, C. Del Vecchio Blanco, G. Marone
Journal: Hepatology (2001)

The high incidence of tumor seeding along the needle tract, reported by Llovet et al., 1 has not been reported as a complication of radiofrequency (RF) ablation of hepatocellular carcinoma (HCC) with the cooled needle in studies that date from 1996 and include several hundred patients. [2]3][4][5][6][7] It was recently reported in preliminary form only for treatment of metastases. 8 The authors did not provide a convincing explanation for the discrepancy between their data and other series.The duration of the follow-up or a lack of accurate ultrasound (US) or computed tomography (CT) monitoring cannot account for the difference, because most studies were published more than 2 years ago and the follow-up is now far longer than that of the Barcelona experience.In our center, we started performing ethanol injection in 1986, laser thermal ablation in 1997, and RF thermal ablation with the cooled needle in 1999.To date, we have used RF in 63 patients with a total of 77 nodules; the follow-up averages 16 months (range, 1-42 months).Follow-up is performed with US every 3 months and spiral CT every 6 months.Among various minor and major complications including 1 death, we never saw tumor seeding along the needle tract.The absence of this complication in our and other experiences, in contrast with the Barcelona results, is probably due to the avoidance of direct puncture of subcapsular tumors, a criterion adopted by us and by other centers.Subcapsular HCC were reported previously to give a high incidence of complications at echoguided biopsy, 9 mainly hemorrhage and hemoperitoneum, and these complications were related to the size of the needle.Some cases of seeding were also reported after fine needle biopsy 10,11 and ethanol injection 12 of subcapsular HCC.Therefore, standard practice is to avoid their puncture, particularly when the needle cannot be introduced through a layer of nontumoral liver tissue.In fact, in the 4 HCC cases of the Barcelona group that showed seeding after the procedure, the authors state that it was not possible to perform thermocoagulation when retiring the needle, a procedure that is mandatory for avoiding neoplastic seeding.We are surprised at the high percentage of subcapsular HCC treated in the series of Llovet et al. (11 out of 32 patients!),considering that these tumors are the most favorable for resection.The conclusion that we draw from this study is that puncture of subcapsular HCC (and not only for RF ablation, which utilizes large-caliber needles) entails a high risk of hemoperitoneum, may facilitate neoplastic dissemination outside the liver capsule, and should be avoided.We agree that RF ablation should be considered an experimental procedure until further studies ascertain whether it is cost effective in comparison with ethanol injection or other local-regional treatments.
The Opportunity and Obligation to Eliminate Measles From the United States
Authors: Alan R. Hinman
Journal: JAMA (1979)

ON OCT 4, 1978, the Secretary of the Department of Health, Education, and Welfare, Joseph A. Califano, Jr, announced, "We are launching an effort that seeks to free the United States from measles by October 1, 1982" (statement made in Washington, DC, Oct 4, 1978). In announcing this initiative, the secretary noted the "remarkable progress made in controlling measles in the past 15 years" that made possible such an attempt to "eliminate indigenous cases of measles in this country." The purpose of this article is to describe the epidemiologic and operational history behind this initiative, to present its scientific rationale, and to summarize the major tactics viewed as essential to its successful execution. <h3>Background</h3> Measles has had severe impact in the United States. Outbreaks were reported as early as 1635; a major epidemic occurred in the colonies in the period 1713 to 1715. In 1772, it was reported that 800
Misericordiae medicinae
Authors: M L. Osborn
Journal: BMJ (1980)

dependent of the area of liposclerosis at the beginning of treatment.With leg ulcers there is some evidence' that healing follows a logarithmic curve, large ulcers healing faster than small ones.This biological phenomenon may well apply to the healing of liposclerosis; if so transformation-of the data is essential before paired comparisons are made.In the discussion the authors mention that other methods of assessing healing, such as percentage change, appeared to offer no advantages, but in what respect ?
Table of Contents
Authors: Brad Rovin, Kam-Tao Li, Siu-Fai Lui, Sharon Andreoli, Winston Wing, Shing Fung, Anne Hradsky, Latha Kumaraswami, Vassilios Liakopoulos, Ziyoda Rakhimova, Gamal Saadi, Luisa Strani, Ifeoma Ulasi, Kamyar Kalantar-Zadeh, Valeria Saglimbene, Giovanni Strippoli, Jonathan Craig, Germaine Wong, Tania Salehi, P Coates, Mai Sugahara, Tetsuhiro Tanaka, Masaomi Nangaku, George Tsokos, Pedro Silva, Carsten Wagner, Olivier Devuyst
Journal: Kidney International (2020)
Neuroendocrinelike (Small Granule) Epithelial Cells of the Lung
Authors: Richard P. DiAugustine, Karen S. Sonstegard
Journal: Environmental Health Perspectives (1984)

The presence of neuroendocrinelike epithelial cells in the lung of numerous species has been demonstrated by light and electron microscopy. Histochemical methods used to identify these cells have included staining with silver, amine-type fluorescence (APUD cell), periodic acid Schiff (PAS)-lead hematoxylin, and immunohistochemical localization of neuron-specific enolase. Cytoplasmic dense core vesicles (70-200 nm in diameter) have served as the major ultrastructural characteristic. Lung neuroendocrinelike cells have been shown to occur in fetal and adult mammals as solitary-type cells or as distinct organoids known as neuroepithelial bodies ( NEBs ). Although the frequency of both populations is considered low, solitary-type cells with dense-core granules can be found in as high as 5% of epithelial cells in the cricoid region of the guinea-pig larynx. The solitary cells can be found throughout the airways of mammals, whereas the NEBs are confined to the intrapulmonary airways. Unmyelinated fibers have been traced from the lamina propria and into the NEB, where they ramified between the component cells of the NEB. The function of lung neuroendocrinelike cells is not known, but morphological and cytochemical studies suggest that the NEBs are intrapulmonary chemoreceptors that can respond to changes in airway gas composition. Hypoxia or hypercapnia has been shown to decrease the amine cytofluorescence in these organoids and apparently to increase the exocytosis of dense core vesicles from the basal region of the cell. Immunohistochemical studies have suggested that some lung epithelial cells may contain a known neuropeptide(s), but further investigation is needed to confirm the presence of such compounds in lung neuroendocrinelike cells and their physiochemical properties. Apparent hyperplasia of lung neuroendocrinelike cells can occur readily in hamsters treated with diethylnitrosamine. It has been postulated that human lung tumors with endocrinelike properties, namely, bronchial carcinoids and lung small cell carcinomas, may originate from lung neuroendocrinelike cells. However, a more plausible explanation, based on cytokinetic studies of epithelial neuroendocrinelike cells in the lung and other organs, is that these cells originate from a nonneuroendocrine population. Interaction of such a progenitor cell population with selected carcinogens may lead to stimulation of the rate of normal differentiation or, alternately, to selection of an abnormal route of differentiation that possesses a neuroendocrine phenotype.
Junior doctors say what the BMA should do now to stop the new contract
Authors: Abi Rimmer
Journal: BMJ (2016)

The BMA’s Junior Doctors Committee announced last Saturday that it was planning other action to resist a new contract for junior doctors in England, after it suspended three rounds of strikes http://careers.bmj.com/careers/advice/BMA_considers_plans_after_suspending_junior_doctor_strikes. So far details of the actions have not been released. Junior doctors express their views on what should happen next
(39) Blue rubber bleb naevus syndrome
Authors: C. B. Zachary, R. S. Wells, C. Joiner
Journal: British Journal of Dermatology (1983)

Journal Article (39) Blue rubber bleb naevus syndrome Get access C. B. Zachary, C. B. Zachary Guy's Hospital, St Thomas' Street, London SE1 9RT Search for other works by this author on: Oxford Academic Google Scholar R. S. Wells, R. S. Wells Guy's Hospital, St Thomas' Street, London SE1 9RT Search for other works by this author on: Oxford Academic Google Scholar C. Joiner C. Joiner Guy's Hospital, St Thomas' Street, London SE1 9RT Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 109, Issue s24, 1 July 1983, Pages 93–96, https://doi.org/10.1111/j.1365-2133.1983.tb11646.x Published: 01 July 1983
Phase II Trial of Taxol, an Active Drug in the Treatment of Metastatic Breast Cancer
Authors: F. A. Holmes, R. S. Walters, R. L. Theriault, A. U. Buzdar, D. K. Frye, G. N. Hortobagyi, A. D. Forman, L. K. Newton, M. N. Raber
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Phase II Trial of Taxol, an Active Drug in the Treatment of Metastatic Breast Cancer Get access Frankie Ann Holmes, Frankie Ann Holmes * Section of Breast Medical Oncology, Department of Medical Oncology, The University of Texas M. D. Anderson Cancer CenterHouston, Tex * Frankie Ann Holmes, M.D., The University of Texas M. D. Anderson Cancer Center-Box 95, 1515 Holcombe Blvd., Houston TX 77030. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ronald S. Walters, Ronald S. Walters Section of Breast Medical Oncology, Department of Medical Oncology, The University of Texas M. D. Anderson Cancer CenterHouston, Tex Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard L. Theriault, Richard L. Theriault Section of Breast Medical Oncology, Department of Medical Oncology, The University of Texas M. D. Anderson Cancer CenterHouston, Tex Search for other works by this author on: Oxford Academic PubMed Google Scholar Aman U. Buzdar, Aman U. Buzdar Section of Breast Medical Oncology, Department of Medical Oncology, The University of Texas M. D. Anderson Cancer CenterHouston, Tex Search for other works by this author on: Oxford Academic PubMed Google Scholar Debra K. Frye, Debra K. Frye Section of Breast Medical Oncology, Department of Medical Oncology, The University of Texas M. D. Anderson Cancer CenterHouston, Tex Search for other works by this author on: Oxford Academic PubMed Google Scholar Gabriel N. Hortobagyi, Gabriel N. Hortobagyi Section of Breast Medical Oncology, Department of Medical Oncology, The University of Texas M. D. Anderson Cancer CenterHouston, Tex Search for other works by this author on: Oxford Academic PubMed Google Scholar Arthur D. Forman, Arthur D. Forman Division of Medicine, Department of Neuro Oncology, The University of Texas M. D. Anderson Cancer Center Search for other works by this author on: Oxford Academic PubMed Google Scholar Lesley K. Newton, Lesley K. Newton Division of Medicine, Department of Neuro Oncology, The University of Texas M. D. Anderson Cancer Center Search for other works by this author on: Oxford Academic PubMed Google Scholar Martin N. Raber Martin N. Raber Clinical Trials Administration, Department of Medical Oncology, The University of Texas M. D. Anderson Cancer Center Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 24, 18 December 1991, Pages 1797–1805, https://doi.org/10.1093/jnci/83.24.1797-a Published: 18 December 1991 Article history Received: 23 July 1991 Revision received: 03 October 1991 Accepted: 04 October 1991 Published: 18 December 1991
一项研究与黑色素瘤相关的 UV 暴露和遗传风险的研究
Journal: British Journal of Dermatology (2020)

年在世界范围内占所有新癌症病例的 1Á6% 以及占所有癌症死 亡病例的 0Á6%。一直被认为是黑色素瘤病因的唯一环境因素是紫外线 (UV) 辐射
Insulin Lipoatrophy
Authors: Richard A. Sachson
Journal: JAMA (1976)

<h3>To the Editor.—</h3> In their article entitled "Amelioration of Insulin Lipoatrophy by Dexamethasone Injection" (235:839, 1976), Whitley and associates reported a case of insulininduced lipoatrophy. They demonstrated a significant improvement in the lipoatrophy with direct injection of a mixture of dexamethasone and insulin zinc suspension into the depressed area. An obvious control that is lacking in their "experiment" is the injection of insulin alone directly into the lesion. It has now been fairly well established that this injection of singlepeak insuling into areas of lipoatrophy will produce amelioration of the lipoatrophy. The precise pathogenesis of the lipoatrophy or the reason for its remission with direct injection of single-peak insulin remains unknown. This phenomenon is well established, however, and is certainly much simpler for both patient and physician than mixing dexamethasone with insulin. Inasmuch as Dr Whitley and his associates used 100 units of insulin that is single peak, it is
Small Slam
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Licensure Statistics for 1962
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: Anna S. Lok
Journal: Hepatology (2016)

Potential conflict of interest: Nothing to report. We thank Zhang et al. for their interest in our systematic review published in hepatology. Unfortunately, the study by Eun et al. was published only in the form of an abstract, which makes determining patient allocation methods and incidence rates of outcomes challenging. In fact, another systematic review from China1 classified this study and reported its outcomes the same way we did. Fortunately, the results do not change whether the study by Eun et al. is included or excluded.
Thousandfold Error
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heartsick
Authors: Miles Hassell
Journal: Annals of Internal Medicine (1998)

Letters15 November 1998HeartsickMiles Hassell, MB, BSMiles Hassell, MB, BSPortland, OR 97225Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-10-199811150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In her beautifully crafted essay [1], Dr. McMurray states that managed care threatens her dream to practice the admirable kind of medicine her father epitomized.How is it that physicians, representatives of an old, honorable, independent profession, are threatened by managed care? Managed care companies offer a product: a physician chooses whether to be their agent. Why do physicians elect to be the agents, then bewail the results? Just how far down the road to serfdom have physicians traveled?The answer for Dr. McMurray and other primary care physicians who decry the result of their adoption of ...References1. McMurray JE. Heartsick. Ann Intern Med. 1998; 128:315-6. Google Scholar Author, Article, and Disclosure InformationAffiliations: Portland, OR 97225 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1998Volume 129, Issue 10Page: 838KeywordsFallsPreferred provider organizationsPrimary care physiciansResidency Issue Published: 15 November 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
The autonomous heart in diabetic autonomic neuropathy
Authors: S. Vaisrub
Journal: JAMA (1976)

When autonomic neuropathy involving the cardiovascular system of a diabetic patient is manifested by postural hypotension, it is easily recognizable. Much less obvious and less well known is the effect of the neuropathy on the regulation of the heart rate. That this effect may be striking could be surmised from animal experiments<sup>1</sup>and, more important, from the unique model of cardiac denervation provided by cardiac transplantation in the human. Griepp et al<sup>2</sup>demonstrated that the heart rate increased only slightly during the initial phase of exercise in patients with transplanted hearts. A pronounced increase occurred later in exercise, presumably when catecholamines reached the heart after they had been released into the circulation from extracardiac sites. In some patients, the heart rate barely changed during maneuvers designed to stimulate or inhibit the autonomic nervous system. Lloyd-Mostyn and Watkins<sup>3</sup>recently reported a near-total nonsurgical cardiac denervation in a patient
THE ACTIVE OXYTOCIC PRINCIPLE OF ERGOT
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impact de l’utilisation du système Endocuff en coloscopie sur le taux de détection d’adénome: méta-analyse d’essais randomisés contrôlés
Journal: Endoscopy (2018)

Introduction Les performances de la coloscopie assistée par Endocuff en terme de taux de détection d’adénome par comparaison à la coloscopie standard sont discutées. Cet article rapporte une méta-analyse d’essais randomisés contrôlés.
The American Text-Book of Obstetrics.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal