tbuckley/cabot-search huggingface dataset:
Ankylosing spondylitis and HLA-B27: restriction fragment length polymorphism and sequencing of an HLA-B27 allele from a patient with ankylosing spondylitis
Authors: Mohamed Abuzakouk Cliona O'farrelly
Journal: Annals of the Rheumatic Diseases (1993)

Food intolerance in rheumatoid arthritisSir: We read with interest the two papers by Drs van de Laar and van der Korst on food intolerance in rheumatoid arthritis (RA). 1 2 It appears from this extensive but short study of patients with seropositive RA that rheumatoid disease in a small subgroup is sensitive to dietary manipulation.Identification of these patients is, however, a problem.We have previously shown that significant gut abnormalities are associated with raised levels of IgA rheumatoid factor (RF) and dietary protein specific IgG in patients with RA and suggested that these changes might identify patients who would respond to dietary manipulation.3Gendre and colleagues have described villous atrophy and other histological abnormalities of the small intestine in patients with RA.4These changes were more significant among IgM RF negative patients (who are often IgA RF positive).In the recent study the number of patients examined histologically was small, therefore a firm conclusion cannot be reached.Moreover, it is likely that by excluding IgM RF negative patients with RA some food intolerant patients might have been missed.Furthermore, investigation of intestinal structure and function in RA is severely hampered by the damaging effects of non-steroidal anti-inflam- matory drugs, which are so often used by patients with RA.Thus a fundamental question remains extremely difficult to answer-that is, whether gut abnormalities and any of the manifestations associated with these abnor- malities in patients with RA are secondary to the disease process and its treatment or are of primary pathogenic significance.
The measles epidemic. The problems, barriers, and recommendations. The National Vaccine Advisory Committee
Journal: JAMA (1991)

The nation has experienced a marked increase in measles cases during 1989 and 1990. Almost one half of all cases have occurred in unvaccinated preschool children, mostly minorities. The principal cause for the epidemic is failure to provide vaccine to vulnerable children on schedule. Major reasons for the low vaccine coverage exist within the health care system itself, which creates barriers to obtaining immunization and fails to take advantage of many opportunities to provide vaccines to children. Ideally, immunizations should be given as part of a comprehensive child health care program. However, immunization cannot await the development of such an ideal system. Essential changes can and should be made now. Specific recommendations include improved availability of immunization; improved management of immunization services; improved capacity to measure childhood immunization status; implementation of the two-dose measles vaccine strategy; and laboratory, epidemiologic, and operational studies to further define the determinants of decreased vaccine coverage and to develop new combinations of vaccines that can be administered earlier in life. The measles epidemic may be a warning flag of problems with our system of primary health care.
Analysis of Polychlorinated Biphenyls (PCBs) in Human Serum
Authors: M. Luotamo, J. Jarvisalo, A. Aitio
Journal: Environmental Health Perspectives (1985)

Polychlorinated biphenyls (PCBs) are widely dispersed in the environment. Occupational exposure to PCBs takes place, e.g., in manufacture and repair of capacitors and transformers. A special type of exposure of workers to PCBs may occur in connection with accidents where capacitors or transformers containing PCBs products are damaged, as in the case of a fire or electric arcing. The quantitation of PCBs poses several problems: There are 209 different homologs and isomers of PCBs. The isomers of PCBs have different responses in the electron capture detector, and the pattern of PCBs in biological specimens is different from that of commercial products. In this study a method was worked out for the analysis of PCBs in serum with the purpose of estimating occupation exposure to PCBs. The PCBs were extracted to an organic solvent, and the extract was purified by use of sulfuric acid and silica columns. Capillary gas chromatography with electron capture detection was used. For separation, temperature programming was used.
ABC of subfertility: male subfertility
Journal: BMJ (2003)

We have reported that individual clinicians are not as influenced by the presentation of risk in population terms as they are by relative risk (Heller et al, submitted for publication), while others have found that the "number needed to treat" statistic (which also relies on measures of absolute risk) is poorly understood by doctors and lay people. 29 30 It remains for us to examine whether new measures of population impact like PIN-ER-t can be more easily understood and used in health policy related decision making than traditional methods of communicating risk.We are developing a research programme to explore this further.Contributors and sources: The authors work at the Evidence for Population Health Unit, aiming to develop a public health counterpart to evidence based medicine.The measure described here is one of a series of population impact measures developed to use evidence combined with routinely collected data to provide local context to measures of risk and benefit and support public health policy decision making.
"PHYSICAL ACTIVITY IN PATIENTS WITH COPD". H. WATZ, B. WASCHKI, T. MEYER AND H. MAGNUSSEN. EUR RESPIR J 2009; 33: 262-272.
Journal: European Respiratory Journal (2010)

Unfortunately, in table 4 of the above manuscript, the cut-off point of the 6-min walk distance (6MWD) was reported incorrectly.It should have been given as 445 m and not 44 m.The corrected table is presented below.
Abstract 1949: Mouse model of metastatic colorectal cancer by orthotopic transplantation of patient derived organoids
Authors: Takuya Okamoto, Katsuyuki Yaginuma, Satoshi Nagayama, Ryoji Yao
Journal: Cancer Research (2019)

Abstract Cancer metastasis proceeds through multiple steps and metastatic colonization is formed by disseminated tumor cells with proliferative capacity in distant tissues. In the analysis of metastasis, macroscopically completed lesions are often used for subjects, which is attributed to the difficulty to capture the early process occurring in living body and the analysis using human specimen is particularly limited. To capture the metastatic process of colorectal cancer (CRC) and to identify cell population involved in it, we produced the mouse model for CRC by orthotopic transplantation of patient derived organoids (PDOs). Unlike ectopic transplantation models, this model precisely recapitulates the metastasis process in human patients. To evaluate the metastasis potentials, the patient matched organoids from the primary, the synchronous liver metastasis and the post-chemotherapy liver recurrence lesion were established. No significant difference in macroscopic morphology or pathogenic mutations were noted among the organoids. The organoids were marked by fluorescent protein and luciferase fusion gene to be visualized the process over time by in vivo imaging system and injected under rectal mucosa on prolapse. Each graft reflected histopathological feature of the surgical specimen. At the results of observation, the lung metastases were frequently occurred in recurrence organoids mouse models, but little occurred in primary or metastasis ones. The lung metastases were considered to be in the early stage of metastasis, because they spread diffusely in each lung lobes, and could not be confirmed macroscopically. They were forming two state; one appeared to be the embolism in blood vessels around the bronchus and others were the micro-metastases in lung tissue. The orthotropic transplantation of patient-matched PDOs provides unique opportunities to explore the metastasis process of CRC. Citation Format: Takuya Okamoto, Katsuyuki Yaginuma, Satoshi Nagayama, Ryoji Yao. Mouse model of metastatic colorectal cancer by orthotopic transplantation of patient derived organoids [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1949.
ISRAEL
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fighting spirit
Authors: Clare Halsted
Journal: British Journal of Sports Medicine (2000)

Objectives-Recent studies have indicated reduced immunity in trained athletes.Aim-To assess the eVects of aerobic and anaerobic exercise on the phagocytic process in 18-26 year old trained female judoka (n = 8) and untrained controls (n = 7).Methods-Each subject participated randomly in two diVerent testing sessions (aerobic, 20 minutes of treadmill running at 70-80% of maximal heart rate; anaerobic, Wingate anaerobic test).Venous blood samples were drawn before, immediately after, and 24 hours after each session.Results-There were no significant diVerences in basal values of net chemotaxis (chemotaxis -random migration), bactericidal activity, and superoxide anion release between the judoka and the untrained women.There was a significant decrease in net chemotaxis 24 hours after the aerobic exercise in both the judoka (from 64 (19) to 39 (13) cells/field, p<0.02) and the untrained controls (from 60 (7) to 47 (12) cells/field, p<0.05).Bactericidal activity and superoxide anion release did not change significantly after aerobic exercise in either group.There were no significant changes in net chemotaxis, bactericidal activity, and superoxide anion release after anaerobic exercise in either the judoka or untrained women.Conclusions-The decrease in net chemotaxis after aerobic, but not after anaerobic, exercise, suggests that net chemotaxis is aVected by the combination of exercise intensity and duration, and not by the exercise intensity itself.Similar eVects of both exercise sessions in the judoka and the untrained women suggest that training had no eVect on neutrophil function response to aerobic and anaerobic exercises.
Sex and Gender Bias in Illustrations in Anatomy and Physical Diagnosis Texts
Authors: Allen E. Yeakel
Journal: JAMA (1995)

<h3>To the Editor.</h3> —I read with interest and amazement the article by Ms Mendelsohn and colleagues<sup>1</sup>regarding sex and gender bias in medical textbooks. The authors did not pursue their premises to their logical conclusions, however. According to the authors, the "underrepresentation of women in anatomy texts" (ie, more identifiably male pictures, illustrations, drawings, diagrams, and the like than identifiably female pictures, illustrations, drawings, diagrams, and the like) may "create the perception that the male body is 'normal' and the female body 'abnormal.'" Following that conclusion, it follows that all the neutral (not identifiable as male or female) pictures, illustrations, drawings, and diagrams should be banned from medical texts, since that would doubtless create the perception that a substantial number of humans are neither male nor female. This could create anxiety and confusion in the student, since they would never have encountered one of these beings. This could in
Assessment of response to induction therapy and its influence on 5-year failure-free survival (FFS) in Group III rhabdomyosarcoma (RMS): Intergroup Rhabdomyosarcoma Study (IRS)-IV experience
Authors: P. P. Breitfeld, J. Anderson, S. Kao, D. Rodeberg, S. Qualman, S. Wolden, W. Meyer
Journal: Journal of Clinical Oncology (2004)

8513 Background: Initial response to induction chemotherapy (CT) predicts FFS in osteosarcoma and Ewing sarcoma. Current European studies in RMS tailor therapy based on induction response. For IRS IV subjects with Group III RMS, we assessed whether reported response to induction therapy predicted FFS. Methods: We studied 453 Group III subjects who received induction CT, had response assessed at week 8 and continued with protocol therapy. Induction CT was followed by radiation therapy (RT) starting after week 9. Response to induction therapy was determined by radiographic measurement of tumor at weeks 0 and 8. Complete response (CR: complete resolution of disease), partial response (PR: ≥ 50% decrease in the sum of the products of the maximum perpendicular diameters of measurable lesions), no response (NR: < 50% decrease and < 25% increase), or progressive disease (>25% increase) was coded by local institutions. Results: Response rate at week 8 was 77% (CR=21%, PR=56%) but response had no influence on FFS (p=0.89). 272 subjects received only CT during induction. Response rate was 81% (CR=22%, PR=59%) and was independent of histology and tumor size. In these subjects, response did not influence FFS except for those with alveolar histology. 141 other subjects received CT and RT during induction, usually because of a parameningeal primary with intracranial extension. Response rate was 65% (CR=12%, PR=53%) but response had no influence on FFS. 40 subjects received no RT at all (protocol violation) and response to induction CT had no effect on FFS. Conclusion: In IRS IV, response rate to induction therapy was 77% in Group III subjects but induction response had no influence on FFS overall. Table 1. Response rate and FFS by induction therapy and histology No significant financial relationships to disclose.
1985 年至 2015 年间 31 个国家/地区的黑色素瘤死亡率
Journal: British Journal of Dermatology (2020)

恶性黑色素瘤是皮肤癌中致死人数最多的癌症。在英国，约 86% 的黑色素瘤病例是可预防的。许多国家/地区已经实施策略，试图提高黑色素瘤的预防、诊断和治疗的几率。我们的研究旨在探究过去几十年间由黑色素瘤引起的死亡率规律或死亡案例，因为这些信息可能帮助我们评估目前实施的策略是否有效。
CARDIOLOGY AND THE GENERAL PRACTITIONER
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Geburtshilfliches Vademekum, ein kurzes Lehrbuch der Geburtshilfe für Studierende und Aerzte.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Water-Supply of Rural Communities
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Should prophylaxis against osteoporotic fractures ignore bone mineral density?
Journal: BMJ (1999)

Eradicating Helicobacter pylori does not relieve dyspepsia Most patients with dyspepsia do not have a peptic ulcer or other clear explanation for their condition.Around 30% to 70% of patients with such functional dyspepsia have Helicobacter pylori, which always causes chronic inflammation in the stomach.The role of this bacteria in causing symptoms in the absence of peptic ulcer disease, however, has remained contentious because of a lack of adequate trials.On p 833 Talley et al report the results from a large Australasian and European trial.They found that treatment of H pylori relieved dyspepsia symptoms in 24% of patients at 12 months compared with 22% of patients who received placebo.Whether longer term follow up is needed to show symptom relief after treatment remains unknown.
Running and the Development of Disability with Age
Authors: James F. Fries
Journal: Annals of Internal Medicine (1995)

Letters15 March 1995Running and the Development of Disability with AgeJames F. Fries, Gurkirpal Singh, and Helen B. HubertJames F. FriesStanford University School of Medicine, Palo Alto, CA 94304.Search for more papers by this author, Gurkirpal SinghStanford University School of Medicine, Palo Alto, CA 94304.Search for more papers by this author, and Helen B. HubertStanford University School of Medicine, Palo Alto, CA 94304.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-6-199503150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank Dr. Venes for his comments. Prospective longitudinal studies are required to address questions of long-term benefits or costs of vigorous exercise programs, given that a randomized clinical trial is neither ethical or practical. (Imagine randomly assigning a large sample to either run 1000 miles a year or to watch television for a decade!) We reported 8-year results of our ongoing study [1]. Please note two arithmetic errors in Dr. Venes's letter. The baseline level of vigorous exertion in the control group was 87.3 minutes per week rather than 77.3. The percentage increase is therefore 42% rather ...References1. Fries JF, Singh G, Morfeld D, Hubert HB, Lane NE, Brown BW Jr. Running and the development of disability with age. Ann Intern Med. 1994; 121:502-9. Google Scholar2. Fries JF, Morfeld D, Hubert HB. Exercise, musculoskeletal disability, pain, and medical care costs: 9-year longitudinal study (Abstract). Arthritis Rheum. 1994; 37:S198. Google Scholar Author, Article, and Disclosure InformationAffiliations: Stanford University School of Medicine, Palo Alto, CA 94304. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA biomarker perspective on the acute effect of exercise with and without impact on joint tissue turnover: an exploratory randomized cross-over study 15 March 1995Volume 122, Issue 6Page: 475KeywordsClinical trial reportingDisabilitiesExerciseLongitudinal studiesRunning Issue Published: 15 March 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
James Copland (1791-1870), medical encyclopedist
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal