tbuckley/cabot-search huggingface dataset:
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
Authors: Koji Yamaguchi, Masao Tanaka, Hua Zhou, Mo Wang, Chuanqiang Hou, Xing Jin, Xuejun Wu, Hideaki Ito, Kazufumi Honda, Reiko Satow, Eri Arai, Miki Shitashige, Masaya Ono, Tomohiro Sakuma, Shigeru Sakano, Katsusuke Naito, Hideyasu Matsuyama, Tesshi Yamada
Journal: JNCI Journal of the National Cancer Institute (2011)

Bone marrow stromal cell transplantation and vascular endothelial growth factor C administration could enhance the therapeutic lymphangiogenesis effect
The IASLC/ITMIG Thymic Epithelial Tumors Staging Project: Proposals for the N and M Components for the Forthcoming (8th) Edition of the TNM Classification of Malignant Tumors
Authors: Kazuya Kondo, Paul Van Schil, Frank C Detterbeck, Meinoshin Okumura, Kelly Stratton, Dorothy Giroux, Hisao Asamura, John Crowley, Conrad Falkson, Pier Luigi Filosso, Giuseppe Giaccone, James Huang, Jhingook Kim, Marco Lucchi, Mirella Marino, Edith M Marom, Andrew G. Nicholson, Enrico Ruffini
Journal: Journal of Thoracic Oncology (2014)
Pernicious Anemia
Authors: William H. Crosby
Journal: JAMA (1983)

The article by Minot and Murphy<sup>1</sup>had two profound effects on the history of medicine. It presented an effective therapy for a uniformly fatal blood disease and it revolutionized the study of the blood. In 1934, its authors, together with George Whipple, received the Nobel Prize in medicine, the first time it was ever awarded to physicians from the United States. George Richards Minot, the 40-year-old architect of this research, was chief of the medical service at the Huntington Memorial Hospital, a cancer hospital in Boston. William P. Murphy, aged 34 years, in private practice in Brookline, was a junior associate in medicine at the Peter Bent Brigham Hospital who was invited by Minot to participate.<sup>2</sup>Murphy provided access to the patients with pernicious anemia at the Brigham, supervised their therapy, and performed the essential counting of reticulocytes. Minot had learned years before that a reticulocyte crisis heralds
Unilateral primary hematuria
Authors: A. C. Chester
Journal: JAMA (1978)

PRIMARY hematuria is a term used to describe persistent or recurrent unexplained hematuria, gross or microscopic, that has been demonstrated by biopsy specimen to be of glomerular origin.<sup>1</sup>A case of primary hematuria was unusually severe and prolonged, as well as unilateral in origin. <h3>Report of a Case</h3> A 44-year-old man experienced painless hematuria continuously for 16 months. His urine varied in color from that of dark tea to bright red. Packed RBC volume in urine varied between 0.5 and 2 vol%. No clots were noted. The creatinine clearance was 116 ml/min. The proteinuria value ranged between 1.3 and 1.6 g/24 hr, with a urine protein electrophoresis value reflecting a distribution of constituents similar to serum. The patient's packed RBC volume dropped to as low as 26 vol%, with a serum iron level of 44μg/dl and an iron-binding capacity of 333 μg/dl. Cystoscopy demonstrated a bloody efflux from the
Hormonal Genomics
Authors: C. P. Leo
Journal: Endocrine Reviews (2002)

The availability of the human genomic sequence is changing the way in which biological questions are addressed. Based on the prediction of genes from nucleotide sequences, homologies among their encoded amino acids can be analyzed and used to place them in distinct families. This serves as a first step in building hypotheses for testing the structural and functional properties of previously uncharacterized paralogous genes. As genomic information from more organisms becomes available, these hypotheses can be refined through comparative genomics and phylogenetic studies. Instead of the traditional single-gene approach in endocrine research, we are beginning to gain an understanding of entire mammalian genomes, thus providing the basis to reveal subfamilies and pathways for genes involved in ligand signaling. The present review provides selective examples of postgenomic approaches in the analysis of novel genes involved in hormonal signaling and their chromosomal locations, polymorphisms, splicing variants, differential expression, and physiological function. In the postgenomic era, scientists will be able to move from a gene-by-gene approach to a reconstructionistic one by reading the encyclopedia of life from a global perspective. Eventually, a community-based approach will yield new insights into the complexity of intercellular communications, thereby offering us an understanding of hormonal physiology and pathophysiology.
Ancillary indicators in glucose metabolism
Authors: S. Vaisrub
Journal: JAMA (1980)

Immunoreactive insulin assays do not always indicate the serum concentration of insulin secreted by the patient's pancreas. In insulin-treated diabetic patients, circulating endogenous insulin antibodies compete with antibodies for the added labeled hormone. The immunoassay may then fail to detect a coexisting insulinoma or to diagnose a factitious hypoglycemia induced by surreptitious insulin injections. In these situations a "collateral," less direct approach such as measurement of correlated connecting (C)-peptide concentration may be more revealing. C-peptide, which forms the connecting link between alpha and beta chains of the proinsulin molecule, is released from the beta cells into the circulatory system when proinsulin is converted into insulin. Secreted in equimolar quantities with insulin, the peptide follows a different metabolic route, but retains a reproducible correlation with insulin. Its determination thus provides a truer reflection of endogenous insulin concentration than the insulin radioimmunoassay. Used as an index of beta-cell function, the response of
Osteonecrosis of the femoral head during pregnancy
Authors: S. Zolla-Pazner
Journal: JAMA (1980)

ONLY nine cases of femoral head necrosis associated with pregnancy have been reported in the medical literature.<sup>1-5</sup>In seven of these nine cases, predisposing causes other than pregnancy may explain the origin of the disease. In two cases, however, pregnancy was the only known factor.<sup>4,5</sup>This case represents the third in which no other associated predisposing factors leading to femoral head necrosis were present. Thus, a small but important number of women in whom groin and leg pain develops during or soon after pregnancy may represent undiagnosed cases of this orthopedic complication. <h3>Report of a Case</h3> A 35-year-old woman (gravida 2, para 1, abortus 1) in the sixth month of pregnancy experienced the sudden onset of left anteromedial midthigh pain of mild severity without radiation. The pain occurred with weight bearing. The pain was initially attributed to probable femoral nerve compression. A severe limp rapidly developed, and the
Progress in Hematology
Authors: W. R. Best
Journal: JAMA (1967)

Scholarly reviews of current topics in hematology have characterized this series, new volumes of which appear every two or three years. The editors have chosen questions in which "... the prime articles were either diffusedly distributed or clouded in controversy...," with the idea that authors might unravel and resynthesize these fields into a more comprehensible view. One chapter concludes thus, "This review has stressed these defects in knowledge and the conflicting nature of the data which are available. Its aim has been to serve as a guide for those who wish to study the many unsolved problems." These words might apply equally to other chapters. The reviews will be of greatest value to the specialist or investigator with a deep interest in a particular topic. The average clinician, however, may find much which is pertinent to problems presented by his patients. There are many chapters of interest in this regard. In
Proceedings of the Midcentury White House Conference on Children and Youth
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation
Authors: Sabrina Torre, Maria J Polyak, David Langlais, Nassima Fodil, James M Kennedy, Irena Radovanovic, Joanne Berghout, Gabriel A Leiva-Torres, Connie M Krawczyk, Subburaj Ilangumaran, Karen Mossman, Chen Liang, Klaus-Peter Knobeloch, Luke M Healy, Jack Antel, Nathalie Arbour, Alexandre Prat, Jacek Majewski, Mark Lathrop, Silvia M Vidal, Philippe Gros
Journal: Nature Immunology (2016)
Archives of Otolaryngology, Chicago
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Disposal of Sewage. A Text-Book for the Use of Engineers, Sanitary Inspectors and Students.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABRAHAM JACOBI-PEDIATRIC PRESIDENT OF THE AMA
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Evaluation of Mediastinoscopy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
This Issue At A Glance
Authors: Lori Baker Schena, John Kerrison
Journal: Ophthalmology (2011)

Using portable spectral domain optical coherence tomography (SD-OCT), Maldonado et al (p. 2315) describe the development of living cellular layers of the human retina and of subcellular specialization at the fovea in the eyes of 31 premature neonates–demonstrating that human foveal development continues after premature birth. In these neonates, ages 31 to 41 weeks postmenstrual age PMA (PMA = gestational age in weeks + chronological age), several signs of migration, redistribution, and growth of subcellular structures were observed, including displacement of retinal layers out of the foveal center as the fovea matured, and the progressive formation of the inner/outer segment band in the opposite direction.
Systemic Mastocytosis
Authors: Cem Akin, Dean D. Metcalfe
Journal: Annual Review of Medicine (2004)

Systemic mastocytosis is a clonal disorder of the mast cell and its progenitor. The symptoms of systemic mastocytosis are due to the pathologic accumulation and activation of mast cells in various tissues such as bone marrow, skin, gastrointestinal tract, liver, and spleen. Recent studies revealed striking differences between the molecular and cellular biology of mast cells in patients with mastocytosis and those of healthy individuals. These findings are being used in formulating diagnostic criteria as well as designing novel treatment approaches to the disease.
No-confidence vote on catheter removal of foreign bodies
Authors: M. Korcok
Journal: JAMA (1982)

Since the mid-1960s, the use of the Foley (balloon) catheter to remove foreign bodies from the esophagus has become increasingly popular among many radiologists, general surgeons, family and emergency physicians, and pediatricians. But, according to results of a recent survey reported to the American Broncho-Esophagological Association meeting in Palm Beach, Fla, those physicians who are specially trained in the removal of such foreign bodies find little use for the device, preferring conventional endoscopic extraction techniques in the presence of adequate airway management capability. The survey, conducted among directors of otolaryngology and thoracic surgery residency programs and members of the Society for Pediatric Radiology, was described by W. Frederick McGuirt, MD, associate professor of otolaryngology at Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC. Completed questionnaires were received from 245 physicians reporting on 1,512 cases of Foley catheter use. McGuirt said that of the 84 otolaryngologist respondents, only five
ECG patterns useful in the diagnosis of intermittent heart block
Authors: J. I. Haft
Journal: JAMA (1972)

Blockages in any of the three intraventricular conduction pathways (the right bundle branch, and anterior superior radiations and posterior inferior radiations of the left bundle branch) have specific effects on the QRS pattern as seen on the standard electrocardiogram. The presence of block in two of the three pathways (manifested by right bundle branch block and left axis deviation, right bundle branch block and right axis deviation, alternating complete right and left bundle branch block, or to a lesser extent left bundle branch block) has been found in many patients with documented intermittent heart block or in patients who subsequently develop permanent complete heart block. The presence of this QRS pattern in patients with histories of syncope or dizziness suggests that their symptoms may be due to intermittent heart block. Such patients should be monitored to document heart block, or should have permanent demand pacemakers implanted, or both.
THU0010 THE ANTI-INFLAMMATORY CYTOKINE INTERLEUKIN 37 IS AN ENDOGENOUS INHIBITOR OF TRAINED IMMUNITY
Authors: Giulio Cavalli, Mark Gresnict, Rob Arts, Travis Nemkov, Angelo D’alessandro, Silvia Giugliano, Elan Eisenmesser, Lorenzo Dagna, Leo Joosten, Mihai Netea, Charles Dinarello
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Trained immunity (TI) is a <i>de-facto</i> innate immune memory program induced in monocytes/macrophages by exposure to pathogens or vaccines, which evolved as a protective mechanism against infections. TI is characterized by rewiring of functional, epigenetic and metabolic programs of innate immune cells such as monocytes and macrophages, which sustain enhanced production of pro-inflammatory cytokines. Since aberrant activation of TI is implicated in inflammatory diseases, tight regulatory mechanisms are likely in place, but the mechanisms responsible for this modulation remain elusive. <h3>Objectives</h3> Scope of this study was to evaluated the role of IL-37, an anti-inflammatory cytokine that curbs inflammation as well as modulates metabolic pathways, as an endogenous regulator of trained immunity. <h3>Methods</h3> The effects of recombinant IL-37 were evaluated in a mouse model of TI induced by the administration of beta-glucan in vivo (survival to a lethal inoculum of infectious agents, production of inflammatory cytokines, recruitment of inflammatory cells at the sites of infection). Subsequently, the effects of IL-37 were evaluated <i>ex vivo</i> on bone marrow monocytes (production of inflammatory cytokines, metabolomic analysis of the activation status of the main pathways of cellular energy metabolism). Finally, we evaluated the association between IL-37 gene polymorphisms and the induction of TI in monocytes of healthy donors with <i>in vitro</i> functional studies. <h3>Results</h3> The exogenous administration of IL-37 abrogated the pro-inflammatory effects of TI, significantly reducing the production of pro-inflammatory cytokines and the survival of experimental animals subjected to a model of disseminated infection. The inhibitory effects of IL-37 on TI were also associated with reduced recruitment of neutrophils at sites of inflammation. IL-37 and TI programs had differential and opposite effects on the modulation of cellular energy metabolism of monocytes. In humans, polymorphisms in the IL-37 gene were associated with reduced activation of TI programs and reduced production of inflammatory cytokines by healthy donor monocytes. <h3>Conclusion</h3> In conclusion, IL-37 emerges as an endogenous regulator of TI, which makes this cytokine a potential therapeutic target in immune-mediated pathologies. <h3>References</h3> [1] M. G. Netea, et al., Trained immunity: A program of innate immune memory in health and disease. Science. (2016). [2] G. Cavalli, C. A. Dinarello, Suppression of inflammation and acquired immunity by IL-37. Immunol Rev (2018). <h3>Disclosure of Interests</h3> None declared
Pediatriia, Moscow
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Meet the First Authors
Journal: Circulation Research (2021)

his MD and MBA from the University of North Carolina at Chapel Hill.His research involves biosignal recording and interpretation using traditional signal processing and machine learning to understand cardiac physiology and translate insights into clinical tools.He hopes to establish his career as a physician-scientist by developing solutions for clinical needs in contemporary electrophysiology.Outside of his research and clinical pursuits, A.J. enjoys athletics of all kinds (especially sand volleyball), travelling and live music.He can be found on Twitter @rogersaj_md.