POS1000-HPR CORRELATION OF ABNORMAL DIET AND ABNORMAL LIFESTYLE WITH INFLAMMATORY MARKERS AND RAPID 3 SCORE IN AUTOIMMUNE RHEUMATIC DISEASE-RELATED ARTHRITIS (RA, SPA AND PSA) AFTER TREATMENT
Authors: S. S, A. R. K, R. Patel, V. As, V. Kr Rao
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> It is considered that unhealthy diet and unhealthy lifestyle has a possible role in inflammation of patients with Rheumatoid arthritis (RA), Spondyloarthritis (SpA) and Psoriatic arthritis (PsA). <h3>Objectives</h3> We set out to find out the role of unhealthy diet and unhealthy lifestyle in the regulation of inflammation after treatment in our patients with autoimmune arthritides such as RA, SPA, PSA. <h3>Methods</h3> A retrospective analysis was carried out using a questionnaire on diet and lifestyle for our defined study population. Our source data was analyzed for inflammatory markers such as CRP, ESR and RAPID 3 scores post-treatment for the patients who filled the questionnaire. A total of 56 patients participated who visited our clinic. After obtaining informed consent, data was gathered through interview method and was further correlated with ESR, CRP and RAPID 3 scores post treatment. Based on consensus, unhealthy diet was defined as consuming red meat anytime, having more than two teaspoons of sugar per day, smoking any amount or in any frequency, and daily alcohol consumption beyond the usual acceptable standard daily limits. Unhealthy lifestyle was defined as spending more than 6 hours per day sitting without taking any break and never engaging in any physical exercises. All the parametric measures were represented as mean ± SEM, and categorical variables were represented in contingency tables as number of incidences/occurrences. The continuous variables were compared by One-way Anova, categorical variables were analyzed by Chi-square test (non-parametric test) and correlation analysis was performed using Pearson's correlation test. The p&lt;0.05 was considered as statistically significant. <h3>Results</h3> Average age of our study group of 56 patients was 48 years, 64% were female, 50% were homemakers, mean duration of treatment was 51 months, predominance of RA (42%), PsA patients (25%), SPA (31%) and a few overlaps. Mean weight was 67.6kg and mean height was 158.76cms. 77% were on combination of CS DMARDS + TS DMARDS. 46% reported they consumed red meat any time, 68% consumed sugar more than 2 teaspoons per day, 9% were smokers while 21 % consumed alcohol daily above the usual defined daily limits. 34% of study population were sedentary, 17% sitting for long hours without break, while 38% with minimal or no exercise. We observed no statistically significant (p 0.5798) correlation between unhealthy diet and RAPID 3 scores post treatment. Similarly, there was no statistically significant correlation between unhealthy diet and ESR (P 0.09) and CRP (p 0.7). There was again no statistically significant correlation between unhealthy lifestyle and CRP (p 0.539), ESR (p 0.164) and RAPID 3 scores (p 0.7) post treatment. However when we analyzed the unhealthy lifestyle parameter sitting for more than 6 hours without break separately we found the correlation of sitting for more than 6 hours without break and RAPID 3 scores to be statistically significant in our study population (p 0.04). <h3>Conclusion</h3> In our study group with limited number of patients we found no statistically significant correlation of unhealthy diet or unhealthy life style in regulation of inflammation post treatment in patients with inflammatory arthritides (RA, SpA and PsA). However, we found that sitting for 6 hours without break and RAPID 3 scores statistically correlated well. This possibly indicates that those patients with inflammatory arthritides (RA, SpA, PsA) who did not move from one place beyond 6 hours in a day had persisting poor quality of life even after treatment suggesting that "Sitting beyond 6 hours without a break could be deemed as the new smoking". But, more patient numbers would be required to retest the same hypothesis at a later stage. <b>Unhealthy Lifestyle vs Rapid 3 scores Correlation.</b> <b>Criteria: Sitting for More than 6 Hours.</b> p value 0.04 <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.