tbuckley/cabot-search huggingface dataset:
Daphne
Authors: Ada C. Rahn
Journal: Annals of Internal Medicine (2014)

Ad Libitum16 December 2014DaphneAda C. Rahn, MDAda C. Rahn, MDFrom Glen Ellyn, IllinoisSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M14-0822 Audio Reading - “Daphne” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Daphne," by A.C. Rahn. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail a heavy numbness seized her limbs, thin bark closed over her breasts, her hair turned into leaves, her arms into branches, her feet so swift a moment ago stuck fast in slow-growing roots, her face was lost in the canopy.—Ovid's Metamorphoses... Author, Article, and Disclosure InformationAffiliations: From Glen Ellyn, IllinoisNote: Lines in italics taken from “An Essay on the Shaking Palsy,” by James Parkinson (originally published by Sherwood, Neely, and Jones [London, 1817]).Current Author Address: Ada C. Rahn, MD; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Daphne” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Daphne," by A.C. Rahn. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 16 December 2014Volume 161, Issue 12Page: 910KeywordsDisclosureEmotionsMuscular dystrophiesParalysisRunningWalking ePublished: 16 December 2014 Issue Published: 16 December 2014 CopyrightCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
DIVIDENDS, TODAY AND TOMORROW
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial Board
Authors: Elizabeth Schotter, Brennan Payne, Alex White, Geoffrey Boynton, Jason Yeatman, Lindsey Drayton, Jessica Miles, Rolf Van Der Sanden, Patrick Scheffmann, Ralph Adolphs, Renee Baillargeon, Nick Chater, Peter Dayan, Stanislas Dehaene, Daniel Dennett, Yadin Dudai, Andreas Engel, Martha Farah, Angela Friederici, Okihide Hikosaka, Ray Jackendoff, Philip Johnson-Laird, Nancy Kanwisher, Christof Koch, Marta Kutas, Nikos Logothetis, James Mcclelland, Earl Miller, Elizabeth Phelps, Russell Poldrack, Marcus Raichle, Trevor Robbins, Anthony Wagner, Vincent Walsh, Arielle Tambini, Lila Davachi, Nathaniel Rabb, Philip Fernbach, Steven Sloman
Journal: Trends in Cognitive Sciences (2019)
Alopecia areata: a review of disease pathogenesis
Authors: F. Rajabi, L.A. Drake, M.M. Senna, N. Rezaei
Journal: British Journal of Dermatology (2018)

Alopecia areata is a disease that causes hair loss, although it does not always look the same and its course is unpredictable. It typically presents as small spots of reversible hair loss on the beard or scalp that can easily be treated. It can also result in total scalp baldness (called alopecia totalis) with devastating psychological impacts for some patients, inadequate treatment options, and frequent relapses. This article is a narrative review of the main events that cause alopecia areata, conducted by researchers based in Iran and the U.S.A. Many environmental and genetic factors are involved in the development of alopecia areata but the mainstream event is an attack on hair follicles by the immune system, which usually serves to protect the body from harmful 'foreign' substances or illnesses. In a normal state, hair follicles are kept in a sanctuary out of reach of the immune system. A breach in this sanctuary activates the immune cells against hair follicles. This happens because the immune system has never been exposed to the hair follicles so it recognizes them as foreign material. What causes this breach is a matter of debate. It could happen as a result of a problems in the central immune system or a disturbance in the follicular environment, i.e. close to the follicles. Psychological stress has also been linked to both the initiation and exacerbation of alopecia areata. A cell line called the mast cells is the link between the immunologic (immune system) events and psychological stress. Stress activates mast cells leading to the release of histamine and other inflammation‐causing factors. Multiple treatment strategies have emerged in recent years aiming at immunological targets, called biologic agents, but most of them have not been able to establish long‐lasting remissions. This may be due to the complex nature of the immunologic events which cannot be targeted with a single agent. Overlooking strategies that aim to kick‐start the regrowth of hair, after treatments that restore the immune sanctuary, might be another reason for treatment failures.
Data Errors in Table 2
Journal: JAMA (2017)

Agnes Y. Y. Lee, MD, MSc; Pieter W. Kamphuisen, MD, PhD; Guy Meyer, MD; Rupert Bauersachs, MD; Mette S. Janas, MD, PhD; Mikala F. Jarner, MSc; Alok A. Khorana, MD; for the CATCH Investigators
Obituary Listing
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
B.C.G
Authors: K. N. Irvine
Journal: BMJ (1949)

In rieumatoid arthritis, however, most astonishingly, vaccines are still employed.Here is a disease, or group of diseases per- haps, of unknown aetiology which, upon a hypothesis un- supported by evidence, is being treated with complex chemical bodies whose action is not known and which have never been proved to be of more value than boiled tap water.After years of consistent failure and disappointment many hours of time and hundreds of pounds are still being wasted every year upon their preparation and administration.Perhaps even more signifi- cant is that the ideas underlying their use obstruct the intro- duction of new conceptions.-Iam, etc., Beckenham, Kent.
A note from the editors: changes and stability – looking back to 2012 and forward to 2013
Authors: None Eurosurveillance editorial team
Journal: Eurosurveillance (2013)

Preview this article: A note from the editors: changes and stability – looking back to 2012 and forward to 2013, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/18/1/art20342-en-1.gif
Mining an Abandoned Vein
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorials
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Do Surgeons Wish to Become Doctors?
Authors: N Ibery, P M Patel, P J Robb
Journal: Journal of the Royal Society of Medicine (2006)

To gauge opinion among otolaryngologists about their wish to retain the title Mr, Miss, Ms or Mrs or to adopt the title of doctor.An e-mail questionnaire sent to all members of ENT-UK (The British Association of Otolaryngologists-Head and Neck Surgeons), who had registered an e-mail address with the ENT-UK secretariat.The specialty group of otolaryngologists in the UK.723 recipients of e-mails, who were members or fellows of a surgical Royal College and, by convention in the UK, entitled to adopt the title Mr, Miss, Ms or Mrs.304 recipients of the e-mail questionnaire responded. 39% were not aware of any proposals to change the convention, addressing surgeons as 'doctor' in the future. Overall, 61.8% were in favour of retaining the current convention and retaining the title Mr or a female equivalent. Applying the null hypothesis that most surgeons would not like to change a title, the chi(2) test produced a highly significant P value of 0.0002. Of female respondents, however, only 43% supported retention of the current convention. Using Fisher's exact test to compare female and male respondents, the two-sided P value was highly significant at 0.006, with female respondents favouring the title of doctor.A large proportion of ENT surgeons in the UK responded to the questionnaire. They were unaware of proposals to change the current convention of address for surgeons. A significant number of those responding were in favour of retaining the current convention. The small proportion of female respondents indicated a preference for being addressed as 'doctor'.
Dynamic measurements of the acute and chronic effects of lysosomotropic agents on hepatocyte lysosomal pH using flow cytometry*1, *2
Authors: B MYERS
Journal: Hepatology (1995)

Previous investigators measuring the pH of lysosomes have used digitized video microscopy (DVM) in freshly isolated or cultured cells. Although useful, this technique is time consuming, requires the use of an image analysis system, and is limited by the fact that measurements can be made in only a relatively small number of cells. The aim of this study was to develop and initially apply a technique using flow cytometry to make dynamic measurements of lysosomal pH in a large number of living hepatocytes. Rats were injected intraperitoneally with fluorescein isothiocyanate-dextran (FITC-Dex), a pH-sensitive fluorescent probe that is sequestered into lysosomes. Hepatocytes were isolated 16 hours after injection by collagenase perfusion. Lysosomal pH was measured in 20,000 hepatocytes per animal using flow cytometry with excitation at 488 nm and emission at 530 nm (pH sensitive) and 585 nm (pH insensitive). A standard curve of pH versus the 530/585 nm ratio was generated with FITC-Dex-loaded hepatocytes by equilibrating intralysosomal pH with extracellular pH using ionophores and metabolic inhibitors. The acute effects of chloroquine and methylamine were determined by exposing isolated hepatocytes to these lysosomotropic agents. The effect of chronic administration of chloroquine and Triton WR-1339 (Rutger Chemical, Inc., Irvington, NJ) on lysosomal pH was also measured. Intralysosomal pH was 4.67 + 0.02, nearly identical to the value 4.70 + 0.05 previously measured by us using DVM. Both chloroquine and methylamine caused both rapid (<1 minute), major (0.5 to 2.0 pH units), and dose-dependent increases in lysosomal pH as well as changes in lysosome morphology. In contrast, although chronic chloroquine and Triton WR-1339 administration caused dramatic ultrastructural changes in lysosomal morphology, lysosomal pH was not increased by either of these agents suggesting that their pharmacological mechanisms are not mediated by their effects on lysosomal pH. These results show the utility and validity of using flow cytometry in living cells to quantify dynamic changes in the pH of lysosomes and show a dissociation of morphological and pH responses of hepatocyte lysosomes to chronic treatment with lysosomotropic agents.
Nephrology
Authors: Leonard B. Berman
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aging and Caring
Authors: Paul E. Ruskin
Journal: JAMA (1997)

I was invited to present a lecture to a class of graduate nurses who were studying the "Psychosocial Aspects of Aging." I started my lecture with the following case presentation: The patient is a white female who appears her reported age. She neither speaks nor comprehends the spoken word. Sometimes she babbles incoherently for hours on end. She is disoriented about person, place, and time. She does, however, seem to recognize her own name. I have worked with her for the past 6 months, but she still does not recognize me. She shows complete disregard for her physical appearance and makes no effort whatsoever to assist in her own care. She must be fed, bathed, and clothed by others. Because she is edentulous, her food must be puréed, and because she is incontinent of both urine and stool, she must be changed and bathed often. Her shirt is generally soiled
Primary Care
Authors: Barry Hainer
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Department of Public Health
Authors: James A. McComb
Journal: New England Journal of Medicine (1958)

USE OF TUBERCULIN IN MASSACHUSETTSIt is gratifying to note, from the vantage point of the Massachusetts Public Health Biologic Laboratories, the present greatly increased use of tuberculin in the State. A reduction in the size of the diagnostic dose used has paralleled this increase. This is quite in line with the reports of Palmer and others, including the World Health Organization Tuberculosis Research Office. Evidence has been piling up within the last decade that points to the nonspecific sensitivity demonstrated by doses of 100 to 250 tuberculin units (TU) or more. This problem has been recognized since the early . . .
Subject Index
Journal: Circulation Research (1971)

Acetylstrophanthidin myocardial contraction frequency and onset of cardiac glycoside action, 34 propranolol and digitalis action, 109 Actinomycin-D effect of oxygen on growth of cultured myocardial cells, 148 Action potentials atrial plateau fibers, 62 delay, block, and one-way block in depressed Purkinje fibers, 199 effect of strontium on transmembrane potentials of rabbit sino-atrial node deprived of calcium, 545 function of gating mechanism in A-V conducting system, 136 reentry mechanism in canine ventricular tissue, 3 Actomyosin effects of phosphate or 5'-AMP on contractile proteins of hog carotid arteries, 434 Adenosine monophosphate effects of phosphate or 5'-AMP on arterial actomyosin, 434 Adenyl cyclase autonomic control of cardiac C-AMP, 377 synergy of propranolol and nicotinic acid on inhibition of plasma free fatty acid release, 270 Adipose tissue adrenergic neurohumoral influences on circulation tissue, 389 Adrenal glands serum dopamine-beta-hydroxylase activity, 307 Adrenal medulla serum dopamine-beta-hydroxylase activity, 307 Adrenergic factors frequency-force behavior of in situ ventricular myocardium, 533 Adrenergic innervation local norepinephrine and 5-hydroxytryptamine and hypothalamic blood flow, 492 Adrenergic nerve terminals effects of 6-hydroxydopamine on canine sinus node, 188 Adrenergic receptors action of diazoxide on muscle vascular resistance, 167 Aging effects of hypertension and its reversal on thoracic aorta of rats, 622 Albumin activation of lipoprotein lipase, 649 Alpha-receptor activation local norepinephrine and 5-hydroxytryptamine and hypothalamic blood flow, 492 Alpha-receptor blockade adrenergic neurohumoral influences on circulation and lipolysis in omental adipose tissue, 389 distribution theory of resistance of neurogenic vasoconstriction to, 179 Alveolar pressure extra-alveolar vessels and edema development in excised dog lungs, 524 Ameroid constriction DNA synthesis and mitoses in coronary collateral vessels of the dog, 671