tbuckley/cabot-search huggingface dataset:
Multiparametric Magnetic Resonance Imaging for the Detection of Clinically Significant Prostate Cancer: What Urologists Need to Know. Part 1: Acquisition
Authors: Rianne R.M. Engels, Bas Israël, Anwar R. Padhani, Jelle O. Barentsz
Journal: European Urology (2019)

Acquiring multiparametric magnetic resonance images of the prostate is not a simple "push-button" approach. To show how image acquisition of prostate multiparametric Magnetic Resonance Imaging (mpMRI) can be optimized. Image protocols, magnetic field strength choice, and the use of receiver coils are discussed. In addition, patient preparation and the recognition, prevention, and mitigation of artifacts are evaluated. Based on expert prostate MRI technologists (MRI radiographers) opinion, the optimal protocol is reviewed, and potential artifacts are determined. The entire acquisition process is presented from initial patient preparation until the end of the imaging. The choice of the used equipment, pulse sequences, and prevention of patient- and imaging-related artifacts are presented. This will be shown in individual patients. Although the Prostate Imaging Reporting and Data System guidelines (2012 and 2016) describe minimal and optimal acquisition protocols for prostate mpMRI, these standards are not always met in daily practice. A major challenge in mpMRI is to obtain high image quality and reduce its variability for radiologic interpretations. A summary of evidence and guidelines for the acquisition of mpMRI of the prostate can set a basic guideline to reduce these variabilities. This article and an accompanying video can be used as a guide by MRI technologists (MRI radiographers) to improve their image acquisitions by optimizing protocols, magnetic field strength choice, and use of receiver coils. We also discuss patient preparation and the recognition, prevention, and mitigation of artifacts. In this first surgery-in-motion contribution, we will show how optimized image acquisition is performed to detect prostate cancer. Both MRI-dependent and patient related factors are discussed.
Influenza Activity—United States, 2000-01 Season
Journal: JAMA (2001)

This report summarizes influenza activity in the United States during October 1-November 25, 2000 (1). Influenza activity was low during this period, and influenza virus isolates were reported from 11 states. The viruses most frequently isolated were influenza A (H1N1) and were well matched by the 2000-01 influenza vaccine strain.
American Psychiatry
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Real-World Data on Clinical Characteristics, Prognosis and Outcome of Primary Plasma Cell Leukemia: A Study of the Greek Myeloma Study Group in the Era of Novel Agents
Authors: Eirini Katodritou, Evangelos Terpos, Sossana Delimpasi, Maria Kotsopoulou, Eurydiki Michalis, Chrysanthi Vadikolia, Marie-Christine Kyrtsonis, Argiris Symeonidis, Nikolaos Giannakoulas, Chrissa Vadikolia, Michalis Michael, Christina Kalpadakis, Theodora Gougopoulou, Chrystalla Prokopiou, Georgia D Kaiafa, Dimitrios Christoulas, Maria Gavriatopoulou, Evlampia Giannopoulou, Vasiliki Lampropoulou, Evgenia Verrou, Efstathios Kastritis, Pavlina Konstantinidou, Achilles Anagnostopoulos, Meletios A Dimopoulos
Journal: Blood (2016)
Percutaneous intervention in plaques with increased temperature is associated with unfavorable outcome in patients with effort angina Christodoulos I. Stefanadis, Konstantinos, P. Toutouzas, Eleftherios Tsiamis, Manolis Vavouranakis, Ioannis Kallikazaros, Charalambos Vlachopoulos, Athanasios Trikkas, Sophia Vaina, Pavlos K. Toutouzas. Hippokration Hospital, Athens, Greece
Journal: Journal of the American College of Cardiology (2001)
From the Alcohol, Drug Abuse, and Mental Health Administration. Cause of AIDS mental problems
Authors: F. K. Goodwin
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Flexible sigmoidoscopy in outpatients with suspected colonic disease.
Journal: BMJ (1981)

we found no relationship between oestrogen receptor status and lymph node metastases, so these two independent prognostic factors may be used together to provide a more accurate pre- diction of prognosis.This may be of particular value in planning the entry criteria and stratification of future adjuvant trials.Clearly, patients with tumours that contain oestrogen receptors but who have no axillary metastases have a good prognosis, and adjuvant treatment would seem inappropriate for this subgroup.Conversely, patients with node metastases and tumours without receptors have a poor prognosis, the worst of all the subgroups studied.Patients without oestrogen receptors and with no axillary metastases have been identified as a high-risk group, and it would now seem appropriate to include such patients in future trials of adjuvant therapy in early breast cancer.We thank the many surgeons on Merseyside who co-operated in this study.The tumours were collected by Mrs Patricia Clark, who also gave invaluable secretarial help.
Back Cover Image, Volume 40, Issue 1
Authors: Meichen Guo, Hang Song, Kai Li, Minchao Ma, Yang Liu, Qiang Fu, Zhonggui He
Journal: Medicinal Research Reviews (2019)

Description of the back cover image: The cover image is based on the REVIEW ARTICLE A new approach to developing diagnostics and therapeutics: aggregation-induced emission based fluorescence turn-on by Meichen Guo et al., https://doi.org/10.1002/med.21595.
Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2011
Authors: D E Furst, E C Keystone, J Braun, F C Breedveld, G R Burmester, F De Benedetti, T Dörner, P Emery, R Fleischmann, A Gibofsky, J R Kalden, A Kavanaugh, B Kirkham, P Mease, J Sieper, N G Singer, J S Smolen, P L C M Van Riel, M H Weisman, K Winthrop
Journal: Annals of the Rheumatic Diseases (2012)
Authors' response
Authors: K. R. Chapman, N. C. Barnes, A. P. Greening, P. W. Jones, S. Pedersen
Journal: Thorax (2010)

Single maintenance and reliever therapyThe paper by Chapman et al 1 reviewing single maintenance and reliever therapy (SMART) in asthma is important in highlighting some of the inadequacies of existing research evaluating this treatment method.The authors also claim that SMART fails to achieve adequate asthma control as measured by GINA criteria and provide a table detailing seven studies and associated control indices.While these outcomes are far from ideal, the authors fail to point out that they were no worse than the comparator arm, which varied across the studies from conventional inhaled steroid therapy to fixed dose combination inhaled steroid/long-acting betaagonist inhalers in high dose (ie, 'optimal therapy').This inadequate control therefore reflects the severity of disease in the trial subject group rather than being a specific deficiency of SMART therapy.It is disingenuous to claim that SMART fails to achieve adequate asthma control without pointing out that in this patient group standard, 'optimal', therapy does no better.
Statistical Methods for Hazards and Health
Authors: Yvonne M. M. Bishop
Journal: Environmental Health Perspectives (1977)

The objective of this article is to document the need for further development of statistical methodology, training of more statisticians and improved communication between statisticians and the many other disciplines engaged in environmental research. Discussion of adequacy of the current statistical methodology requires the use of examples, which will hopefully not be offensive to the authors. Reference is made to recent developments and areas of unsolved problems delineated in three broad areas: enumeration data and adjusted rates; time series; and multiple regression. A brief outline of the ideas behind current methods of analyzing discrete data is followed by a demonstration of their utility using an example of the effects of exposure, sex, and education on bronchitis rates. Examples are listed of the ubiquity of the time component when relating pollution effects to each other and to health effects. An artificial example is used to emphasize the effects of time-dependent autocorrelations, trends, and cycles. References are given to a variety of new developments in time-dependent autocorrelations, trends, and cycles. References are given to a variety of new developments in time-series analysis. Discussion of the pitfalls in multiple regression analysis, and possible alternative approaches is largely based on two recent reviews and includes references to recent developments of robust techniques.
SUICIDE AND ITS MEANS.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Do-It-Yourself Laboratory
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Peptides Prove Predictive for Heart Failure Patients
Authors: Mike Mitka
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IMPOSTORS AMONG ANIMALS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
How to Live Longer.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quantitative myocardial contrast echocardiography improves the detection of hibernating myocardium that lacks contractile reserve with dobutamine echocardiography Sarah Shimoni, Nikolaos G. Frangogiannis, Constandina J. Aggeli, Kesavan Shan, Sherif F. Nagueh, Michael J. Reardon, Rafael Espada, George V. Letsou, Miguel A. Quinones, William A. Zoghbi. Baylor College of Medicine, Houston, TX
Journal: Journal of the American College of Cardiology (2001)
Evaluation of the Potential Role of Chelation Therapy in Treatment of Low to Moderate Lead Exposures
Authors: J. Julian Chisolm
Journal: Environmental Health Perspectives (1990)

In the overall long-term management of lead poisoning, chelation therapy can have short-term benefits; however, these benefits must be accompanied by drastic reduction in environmental exposure to lead if therapy is to have any long-term benefit. This discussion is limited to calcium disodium ethylenediaminetetraacetate (CaNa2EDTA), the chelating agent that has been the mainstay of treatment of lead poisoning for the past 38 years, and to meso-2,3-dimercaptosuccinic acid (DMSA), a new and promising oral chelating agent, which is an orphan drug and is currently classified as an investigational new drug by the U.S. Food and Drug Administration. With both drugs, multiple courses of treatment will be needed if any substantial reduction in body lead burden is to be achieved. A major limitation of CaNa2EDTA is the enormous diuresis of zinc that it produces. DMSA produces a comparable diuresis of lead, a greater decrease in blood lead, and has negligible influence on the urinary losses of zinc, copper, iron, and calcium. Limited experience to date in man has revealed no significant adverse side effects of DMSA. In animals, DMSA will promptly reduce the concentration of lead in brain and kidney, in particular. By contrast, similar 5-day courses of CaNa2EDTA do not produce any net reduction in brain lead. This is important, as the brain is the critical organ of the adverse effects of lead in children. If the efficacy of DMSA is to be comprehensively evaluated ethically in children, new and more sensitive neurochemical, electrophysiologic, or other markers must be developed.
The Histone Deacetylase Inhibitor Entinostat (SNDX-275) Targets Hodgkin Lymphoma through a Dual Mechanism of Immune Modulation and Apoptosis Induction
Authors: Adam Jona, Noor Khaskhely, Daniela Buglio, Jessica A. Shafer, Enrico Derenzini, Catherine M Bollard, Arpad Illes, Michael Andreef, Anas Younes
Journal: Blood (2010)
Allelic Association of Human Dopamine D2 Receptor Gene in Alcoholism-Reply
Authors: Ernest P. Noble
Journal: JAMA (1990)

<h3>In Reply.—</h3> Two types of genetic approaches are used in finding disease susceptibility genes: linkage analysis and association analysis.<sup>1</sup>Because alcoholism is a heterogeneous disorder consisting of a variety of clinical subtypes, we chose for our initial investigation an association study by concentrating on candidate genes, as suggested by previous alcoholism research. Our primary candidate was the dopamine D<sub>2</sub>receptor (DD2R) gene, since the dopaminergic system has been strongly implicated in drug-seeking (alcohol and cocaine) behavior. Brain samples were selected for two reasons. First, by concentrating on individuals with high proportions of severe alcoholism, we hoped for enriched alleles that may be associated with this form of the disease. Second, if a genetic association with alcoholism is found, then the availability of the same brain samples would permit studies of gene expression. In the case of the DD2R gene, its expression occurs in the brain, but has not
In Vitro Release of Arachidonic Acid and In Vivo Responses to Respirable Fractions of Cotton Dust
Authors: T. Andrew Thomson, John H. Edwards, Tarik S. Al-Zubaidy, Robert C. Brown, Alan Poole, Paul J. Nicholls
Journal: Environmental Health Perspectives (1986)

It was considered that the fall in lung function seen after exposure to cotton dust may be attributable in part to the activity of arachidonic acid metabolites, such as leucotrienes as well as to the more established release of histamine by cotton dust. However, we found that cotton and barley dusts elicited poor release of arachidonic acid from an established macrophage like cell line compared with that observed with other organic dusts. In the experimental animal, pulmonary cellular responses to both cotton and barley dust were similar to those evoked by moldy hay and pigeon dropping dusts, although after multiple doses a more severe response was seen to cotton and barley. Since both moldy hay and pigeon droppings elicit a greater arachidonic acid release than cotton or barley, a role for arachidonic acid in inducing the cellular response is less likely than other factors. There are limitations to our conclusions using this system, i.e., the arachidonic acid may be released in a nonmetabolized form, although it is noted that the two dusts with the greatest arachidonic acid release produce their clinical responses in humans largely by hypersensitivity mechanisms.
Paganini
Authors: Richard D. Smith
Journal: JAMA (1967)

Paganini flashed across the musical heavens of Europe like a meteor, regarded as the "King of Violinists," "Demon of Fiddlers," "Virtuoso in Excelsis." Never has a musician created such a furor during his own time and long thereafter. His life and music were shrouded in secrecy, mystery, and legend. Largely self-taught as a violinist, he developed his own technique, enabling him to perform unprecedented feats with dazzling perfection. Not a single new device for the fiddle has been invented since; and the fact that the violin is one of the most difficult instruments to master makes his accomplishments even more amazing.<sup>1</sup> There is a near-law in music that lasting greatness is achieved only by composers. Paganini is the outstanding exception, being remembered as a virtuoso and a revolutionary technical innovator.<sup>2</sup>He was a talented composer also; but we are less familiar with his compositions because they are seldom
Response to Comment on Krul-Poel et al. Effect of Vitamin D Supplementation on Glycemic Control in Patients With Type 2 Diabetes (SUNNY Trial): A Randomized Placebo-Controlled Trial. Diabetes Care 2015;38:1420–1426
Authors: Yvonne H.M. Krul-Poel, Sanne Westra, Suat Simsek
Journal: Diabetes Care (2015)