tbuckley/cabot-search huggingface dataset:
Endotyping, phenotyping and personalised therapy in obstructive sleep apnoea: are we there yet?
Authors: Chris D Turnbull, John R Stradling
Journal: Thorax (2023)

Obstructive sleep apnoea (OSA) was traditionally thought to be mainly caused by obesity and upper airway crowding, and hence OSA management was not personalised according to particular characteristics, with most symptomatic patients receiving continuous positive airway pressure therapy. Recent advances in our understanding have identified additional potential and distinct causes of OSA (endotypes), and subgroups of patients (phenotypes) with increased risk of cardiovascular complications. In this review, we discuss the evidence to date as to whether there are distinct clinically useful endotypes and phenotypes of OSA, and the challenges to the field in moving towards delivering personalised therapy in OSA.
Irreversible covalent Bruton’s tyrosine kinase inhibitor, TAS5315 versus placebo in rheumatoid arthritis patients with inadequate response to methotrexate: a randomised, double-blind, phase IIa trial
Authors: Tsutomu Takeuchi, Sakae Tanaka, Mitsuru Murata, Yoshiya Tanaka
Journal: Annals of the Rheumatic Diseases (2023)

To examine the efficacy and safety of TAS5315, an irreversible covalent Bruton's tyrosine kinase inhibitor, in Japanese patients with rheumatoid arthritis (RA) refractory to methotrexate.In part A of this phase IIa double-blind study, patients were randomised to TAS5315 4 or 2 mg or placebo once daily for 12 weeks; in part B, all patients received TAS5315 for another 24 weeks. The proportion of patients meeting American College of Rheumatology criteria for 20% improvement (ACR20) at week 12 was assessed (primary endpoint).Ninety-one patients were randomised in part A, and 84 entered part B. At week 12, 78.9% of patients achieved ACR20 in the TAS5315 combined group vs 60.0% with placebo (p=0.053), 33.3% vs 13.3% achieved ACR50 (p=0.072) and 7.0% vs 0.0% achieved ACR70 (p=0.294), respectively. More patients receiving TAS5315 than placebo had low disease activity or remission at week 12. Clinical and biomarker improvements were maintained during part B. Adverse event (AE) incidence in TAS5315 was similar to placebo in part A; common AEs with TAS5315 were nasopharyngitis (10.3%), pruritus (6.9%) and cystitis (5.2%). Over 36 weeks, nine patients experienced bleeding events of whom four and two patients recovered with drug continuation and interruption, respectively. Three patients recovered after TAS5315 discontinuation.The primary endpoint was not achieved. TAS5315 appears to have some bleeding risks, but nevertheless demonstrated numerical differences, compared with placebo, in the improvement rates of all measures of RA disease activity. Future analysis of the risk-benefit of TAS5315 should be considered.NCT03605251, JapicCTI-184020, jRCT2080223962.
Is low-risk status a surrogate outcome in pulmonary arterial hypertension? An analysis of three randomised trials
Authors: Bryan S Blette, Jude Moutchia, Nadine Al-Naamani, Corey E Ventetuolo, Chao Cheng, Dina Appleby, Ryan J Urbanowicz, Jason Fritz, Jeremy A Mazurek, Fan Li, Steven M Kawut, Michael O Harhay
Journal: The Lancet Respiratory Medicine (2023)
Global disparities in mortality and liver transplantation in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium
Authors: Jasmohan S Bajaj, Ashok K Choudhury, Qing Xie, Patrick S Kamath, Mark Topazian, Peter C Hayes, Aldo Torre, Hailemichael Desalegn, Ramazan Idilman, Zhujun Cao, Mario R Alvares-da-Silva, Jacob George, Brian J Bush, Leroy R Thacker, Florence Wong, Shiv K Sarin, Shiva Kumar, Sebastián Marciano, Adrián Gadano, Fiona Tudehope, Robert Gibson, Alexander Prudence, Adam Doyle, Hooi Ling Si, Stephen Riordan, Alberto Farias, Patricia Zitelli, Chinmay Bera, Nabiha Faisal, Puneeta Tandon, Monica Dahiya, Marie Jeanne Lohoues, Ponan Claude Regis Lah, Carlos Benítez, Marco Arrese, Yongchao Xian, Jin Guan, Chuanwu Zhu, Yingling Wang, Minghua Su, Man Su, Yanhang Gao, Xinrui Wang, Yongfang Jiang, Feng Peng, Caiyan Zhao, Wei Wang, Lei Wang, Dedong Yin, Mingqin Lu, Yijing Cai, Ningping Zhang, Wanqin Zhang, Hai Li, Fuchen Dong, Xin Zheng, Jing Liu, Hong Tang, Libo Yan, Bin Xu, Linlin Wei, Zhiliang Gao, Zhen Xu, Minghua Lin, Haibin Gao, Jinjun Chen, Beiling Li, Chenghai Liu, Yanyun Zhang, Peng Hu, Huan Deng, Hibat Allah Belimi, Nabil Debzi, Henok Fisseha, Aloysious D Aravinthan, Suresh Vasan Venkatachalapathy, Neil Rajoriya, Rosemary Faulkes, Damien Leith, Ewan Forrest, Danielle Adebayo, James Kennedy, Diana Yung, Wai-Kay Seto, James Fung, Helena Katchman, Liane Rabinowich, Aabha Nagral, Ajay Jhaveri, Anand Kulkarni, Mithun Sharma, C E Eapen, Ashish Goel, Akash Gandotra, Ajay Duseja, Anoop Saraya, Jatin Yegurla, Mohamed Rela, Dinesh Jothimani, Anil Arora, Ashish Kumar, Radha Krishan Dhiman, Akash Roy, Anil C Anand, Dibyalochan Praharaj, Sarai Gonzalez Hueso, Araceli Bravo Cabrera, José Luis Pérez Hérnandez, Oscar Morales Gutierrez, Godolfino Miranda Zazueta, Abraham Ramos-Pineda, Mauricio Castillo Barradas, Rene Male Velazquez, Lilian Torres Made, José Antonio Velarde-Ruiz Velasco, Francisco Félix-Tellez, Jacqueline Cordova-Gallardo, Ruveena Rajaram, Nik Arsyad Nik Muhamad Afendi, Edith N Okeke, David P Nyam, Dalia Allam, Yashwi Haresh Kumar Patwa, Hiang Keat Tan, Wei Lun Liou, Sombat Treeprasertsuk, Salisa Wejnaruemarn, Busra Haktaniyan, Feyza Gunduz, Rahmi Aslan, Abdullah Emre Yildirim, Sezgin Barutcu, Zeki Karasu, Alper Uysal, Enver Ucbilek, Tolga Kosay, Haydar Adanir, Dinç Dinçer, Somaya Albhaisi, Sumeet Asrani, Mohammad Amin Fallahadeh, K Rajender Reddy, Suditi Rahematpura, Jawaid Shaw, Hugo E. Vargas, David Bayne, Scott W Biggins, Natalia Filipek, Paul Thuluvath, Somya Sheshadri, Andrew Keaveny, Andres Duarte Rojo, Ricardo Cabello Negrillo
Journal: The Lancet. Gastroenterology & hepatology (2023)
Financing viral hepatitis: catalysing action for impact
Authors: Jessica Hicks, Grace Singh, Capucine Penicaud, Kiira Gustafson, Cary James, Naomi Burke-Shyne, Colleen Daniels, Oriel Fernandes, Kimberly E Green, Benjamin Cowie, John W Ward, Teri Roberts, David Ruiz Villafranca
Journal: The Lancet. Gastroenterology & hepatology (2023)
Totally Intracorporeal Robot-assisted Unilateral or Bilateral Ileal Ureter Replacement for the Treatment of Ureteral Strictures: Technique and Outcomes from a Single Center
Authors: Kunlin Yang, Xiang Wang, Chunru Xu, Zhihua Li, Guanpen Han, Shubo Fan, Silu Chen, Xinfei Li, Hongjian Zhu, Liqun Zhou, Xuesong Li
Journal: European Urology (2023)
Defining collaborative surveillance to improve decision making for public health emergencies and beyond
Authors: Brett N Archer, Philip Abdelmalik, Sebastien Cognat, Pierre E Grand, Joshua A Mott, Boris I Pavlin, Amal Barakat, Scott F Dowell, Osman Elmahal, Josephine P Golding, Gyanendra Gongal, Esther Hamblion, Sara Hersey, Masaya Kato, Etien L Koua, Gérard Krause, Christopher T Lee, Oliver Morgan, Dhamari Naidoo, Richard Pebody, Mahmoud Sadek, Mohammad N Sahak, Nahoko Shindo, Andrea Vicari, Chikwe Ihekweazu
Journal: The Lancet (2023)
Increased Risk of Thoracic Aortic Aneurysms With JAK2 V617F
Authors: Tetsushi Nakao, Zhi Yu, Caitlyn Vlasschaert, Md Mesbah Uddin, Mark E. Lindsay, Patrick T. Ellinor, Benjamin L. Ebert, Alexander G. Bick, James P. Pirruccello, Pradeep Natarajan
Journal: Journal of the American College of Cardiology (2023)
Self-maintaining macrophages within the kidney contribute to salt and water balance by modulating kidney sympathetic nerve activity
Authors: Qian Zhu, Liang Xiao, Guo Cheng, Jian He, Chunyou Yin, Liang Wang, Qiang Wang, Li Li, Bo Wei, Yuancheng Weng, Fei Geng, Xiao Z. Shen, Peng Shi
Journal: Kidney International (2023)
Drain fluid biomarkers for the diagnosis of clinically relevant postoperative pancreatic fistula: a diagnostic accuracy systematic review and meta-analysis
Authors: Nadya Rykina-Tameeva, Daniel MacCulloch, Luke Hipperson, Yulia Ulyannikova, Jaswinder S Samra, Anubhav Mittal, Sumit Sahni
Journal: International Journal of Surgery (2023)

Pancreatectomy is the only curative treatment available for pancreatic cancer and a necessity for patients with challenging pancreatic pathology. To optimize outcomes, postsurgical complications such as clinically relevant postoperative pancreatic fistula (CR-POPF) should be minimized. Central to this is the ability to predict and diagnose CR-POPF, potentially through drain fluid biomarkers. This study aimed to assess the utility of drain fluid biomarkers for predicting CR-POPF by conducting a diagnostic test accuracy systematic review and meta-analysis.
Aberrant distribution of TFH cells in aged germinal centers reduces stromal cell function
Authors: Michelle Linterman, Alice Denton
Journal: Nature Immunology (2023)

Aberrant distribution of T FH cells in aged germinal centers reduces stromal cell functionThe magnitude and quality of the germinal center response after vaccination decline with age.We found that T follicular helper (T FH ) cells are enriched in the dark zone of germinal centers in aged mice, which impairs the expansion of the follicular dendritic cell network upon immunization and reduces antibody responses. The missionAfter access to clean water and sanitation, vaccines have been one of the most successful interventions for improving human health.However, vaccines do not protect us equally at all stages of our lives.Age-dependent changes in the immune system contribute to the decline in vaccine efficacy in later years.It is known that poor antibody responses are likely to be responsible for the impaired immunity in aging 1 , but the causal cellular and molecular mechanisms remain elusive.We wanted to uncover these mechanisms and see whether we could use this knowledge to boost antibody responses to vaccination in older animals.
Sexual health and treatment-related sexual dysfunction in sexual and gender minorities with prostate cancer
Authors: Daniel R. Dickstein, Collin R. Edwards, Eric J. Lehrer, Elizabeth S. Tarras, Matthew Gallitto, John Sfakianos, Matthew D. Galsky, Richard Stock, Joshua D. Safer, B. R. Simon Rosser, Deborah C. Marshall
Journal: Nature Reviews Urology (2023)
Author Correction: Circulating and urinary tumour DNA in urothelial carcinoma — upper tract, lower tract and metastatic disease
Authors: Kyle M. Rose, Heather L. Huelster, Joshua J. Meeks, Bishoy M. Faltas, Guru P. Sonpavde, Seth P. Lerner, Jeffrey S. Ross, Philippe E. Spiess, G. Daniel Grass, Rohit K. Jain, Ashish M. Kamat, Aram Vosoughi, Liang Wang, Xuefeng Wang, Roger Li
Journal: Nature Reviews Urology (2023)
Cutaneous B‐cell lymphomas: 2023 update on diagnosis, risk‐stratification, and management
Authors: Alexandra C. Hristov, Trilokraj Tejasvi, Ryan A. Wilcox
Journal: American Journal of Hematology (2023)

Approximately one-fourth of primary cutaneous lymphomas are B-cell derived and are generally classified into three distinct subgroups: primary cutaneous follicle center lymphoma (PCFCL), primary cutaneous marginal zone lymphoma (PCMZL), and primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, LT).Diagnosis and disease classification is based on histopathologic review and immunohistochemical staining of an appropriate skin biopsy. Pathologic review and an appropriate staging evaluation are necessary to distinguish primary cutaneous B-cell lymphomas from systemic B-cell lymphomas with secondary skin involvement.Disease histopathology remains the most important prognostic determinant in primary cutaneous B-cell lymphomas. Both PCFCL and PCMZL are indolent lymphomas that infrequently disseminate to extracutaneous sites and are associated with 5-year survival rates that exceed 95%. In contrast, PCDLBCL, LT is an aggressive lymphoma with an inferior prognosis.PCFCL and PCMZL patients with solitary or relatively few skin lesions may be effectively managed with local radiation therapy. While single-agent rituximab may be employed for patients with more widespread skin involvement, multiagent chemotherapy is rarely appropriate. In contrast, management of patients with PCDLBCL, LT is comparable to the management of patients with systemic DLBCL.
Fighting in Sudan threatens its already fragile healthcare system
Authors: Sonia Sarkar
Journal: BMJ (2023)

The intense violence in Sudan is destroying a health system already on its knees, writes Sonia Sarkar Trainee anaesthetist Mazin Abd-alaal Helali was attending an emergency surgery at the government run Khartoum North Teaching Hospital in the Sudanese capital when three bullets pierced the glass windows of the operating theatre. While 29 year old Helali was busy moving the patient to the recovery room, minutes later a bomb fell on the septic theatre, a floor above. “The patient in the septic theatre suffered minor injuries by the shelling but he was shifted out immediately,” Helali told The BMJ. “We were petrified to witness such bombing on the hospital. We never saw this before.” More than 530 people, including 11 healthcare staff, have been killed and 4000 others injured in this African country of 47.9 million people, after violence between the Sudanese armed forces and the paramilitary Rapid Support Force (RSF) broke out on 15 April over power sharing.1 Besides the cities of Khartoum and Omdurman in Khartoum state,2 the conflict has escalated in North Darfur, North Kordofan, South Darfur, and Kassala.3 A chronically under-resourced and fragmented healthcare system with a high infant mortality rate (38 deaths per 1000 live births4), high maternal mortality rate (295 deaths per 100 000 live births5), and low life expectancy (66 years6) has become the biggest collateral damage of the violence (box 1). Of the 820 hospitals across 18 states in Sudan, 134 are in Khartoum state, where the violence is at its worst. Box 1 ### Inadequate even in normal times Doctors told The BMJ that since healthcare in Sudan is controlled by the health ministry, all healthcare centres including primary, secondary, and tertiary care across the states have been affected as administrative work is stalled in violence hit Khartoum. … RETURN TO TEXT
First-in-human prediction of chronic pain state using intracranial neural biomarkers
Authors: Prasad Shirvalkar, Jordan Prosky, Gregory Chin, Parima Ahmadipour, Omid G. Sani, Maansi Desai, Ashlyn Schmitgen, Heather Dawes, Maryam M. Shanechi, Philip A. Starr, Edward F. Chang
Journal: Nature Neuroscience (2023)
Biliary tract injury after cholecystectomy: a surgeon’s worst nightmare
Authors: Jianwei Li, Dingwei Xu, Jie Huang
Journal: International Journal of Surgery (2023)

aDepartment of Hepatobiliary Surgery, Southwest Hospital,Army Medical University,Chongqing, 400038, China bDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan. 243 Dianmian Avenue,Wuhua District, Kunming city, Yunnan,China,650101. fax numbers:+86-087165351281. E-mail address: [email protected] (J. Huang). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC
Authors: Aaron Javitt, Merav D. Shmueli, Matthias P. Kramer, Aleksandra A. Kolodziejczyk, Ivan J. Cohen, Lihi Radomir, Daoud Sheban, Iris Kamer, Kevin Litchfield, Elizabeta Bab-Dinitz, Oranit Zadok, Vanessa Neiens, Adi Ulman, Hila Wolf-Levy, Avital Eisenberg-Lerner, Assaf Kacen, Michal Alon, Ana Toste Rêgo, Elvira Stacher-Priehse, Michael Lindner, Ina Koch, Jair Bar, Charles Swanton, Yardena Samuels, Yishai Levin, Paula C. A. da Fonseca, Eran Elinav, Nir Friedman, Silke Meiners, Yifat Merbl
Journal: Nature Cancer (2023)
Insulin detection in diabetes mellitus: challenges and new prospects
Authors: Eva Vargas, Ponnusamy Nandhakumar, Shichao Ding, Tamoghna Saha, Joseph Wang
Journal: Nature Reviews Endocrinology (2023)

Tremendous progress has been made towards achieving tight glycaemic control in individuals with diabetes mellitus through the use of frequent or continuous glucose measurements. However, in patients who require insulin, accurate dosing must consider multiple factors that affect insulin sensitivity and modulate insulin bolus needs. Accordingly, an urgent need exists for frequent and real-time insulin measurements to closely track the dynamic blood concentration of insulin during insulin therapy and guide optimal insulin dosing. Nevertheless, traditional centralized insulin testing cannot offer timely measurements, which are essential to achieving this goal. This Perspective discusses the advances and challenges in moving insulin assays from traditional laboratory-based assays to frequent and continuous measurements in decentralized (point-of-care and home) settings. Technologies that hold promise for insulin testing using disposable test strips, mobile systems and wearable real-time insulin-sensing devices are discussed. We also consider future prospects for continuous insulin monitoring and for fully integrated multisensor-guided closed-loop artificial pancreas systems. An urgent need exists for technologies and devices capable of frequent and real-time insulin measurements in patients with diabetes mellitus to guide optimal insulin dosing. This Perspective discusses the advances and challenges in moving insulin assays from laboratory-based assays to frequent and continuous measurements in decentralized settings.
Evolutionary patterns and research frontiers in neoadjuvant immunotherapy: a bibliometric analysis
Authors: Shitao Jiang, Yaoge Liu, Han Zheng, Lei Zhang, Haitao Zhao, Xinting Sang, Yiyao Xu, Xin Lu
Journal: International Journal of Surgery (2023)

Research has shown that neoadjuvant immunotherapy may provide more significant clinical benefits to cancer patients undergoing surgery than adjuvant therapy. This study examines the development of neoadjuvant immunotherapy research using bibliometric analysis. As of February 12, 2023, articles on neoadjuvant immunotherapy in the Web of Science Core Collection (WoSCC) were collected. Co-authorship and keyword co-occurrence analyses and visualizations were performed using VOSviewer, while CiteSpace was used to identify bursting keywords and references. The study analyzed a total of 1,222 neoadjuvant immunotherapy publications. The top contributors to this field were the United States (US), China, and Italy, and the journal with the most publications was Frontiers in Oncology. Francesco Montorsi had the highest H-index. The most common keywords were “immunotherapy” and “neoadjuvant therapy.” The study conducted a bibliometric analysis of over 20 years of neoadjuvant immunotherapy research, identifying the countries, institutions, authors, journals, and publications involved in this field. The findings provide a comprehensive overview of neoadjuvant immunotherapy research.
Gellan gum-gelatin scaffolds with Ca2+ crosslinking for constructing a structured cell cultured meat model
Authors: Yan Chen, Linzi Li, Lin Chen, Wei Shao, Xiaohong Chen, Xiaojing Fan, Yaping Liu, Shijie Ding, Xinglian Xu, Guanghong Zhou, Xianchao Feng
Journal: Biomaterials (2023)
Right Ventricular Function and Pulmonary Coupling in Patients With Heart Failure and Preserved Ejection Fraction
Authors: Riccardo M. Inciardi, Martin Abanda, Amil M. Shah, Maja Cikes, Brian Claggett, Hicham Skali, Muthiah Vaduganathan, Narayana Prasad, Sheldon Litwin, Bela Merkely, Annamaria Kosztin, Klaudia Vivien Nagy, Sanjiv J. Shah, Wilfred Mullens, Michael R. Zile, Carolyn S.P. Lam, Marc A. Pfeffer, John J.V. McMurray, Scott D. Solomon
Journal: Journal of the American College of Cardiology (2023)
The potential role of the novel orodispersible film from rice polymer loaded with silkworm pupae hydrolysate and the combined extract of holy basil and ginger for the management of stroke with stress
Authors: Putthiwat Thongwong, Jintanaporn Wattanathorn, Wipawee Thukhammee, Somsak Tiamkao
Journal: Biomaterials (2023)
Predictors of Poor Visual Outcome in Myelin Oligodendrocyte Glycoprotein-Related Optic Neuritis
Authors: Armin Handzic, Marko Tien, Roisin Maire O’Cearbhaill, Jim Shenchu Xie, Kirill Zaslavsky, Jonathan Micieli, Edward Margolin
Journal: Ophthalmology (2023)
Safety and efficacy of secukinumab in patients with giant cell arteritis (TitAIN): a randomised, double-blind, placebo-controlled, phase 2 trial
Authors: Nils Venhoff, Wolfgang A Schmidt, Raoul Bergner, Jürgen Rech, Leonore Unger, Hans-Peter Tony, Stephanie Finzel, Ioana Andreica, David M Kofler, Stefan M Weiner, Peter Lamprecht, Hendrik Schulze-Koops, Christine App, Effie Pournara, Meryl H Mendelson, Christian Sieder, Meron Maricos, Jens Thiel
Journal: The Lancet Rheumatology (2023)
Emerging sensing and modeling technologies for wearable and cuffless blood pressure monitoring
Authors: Lei Zhao, Cunman Liang, Yan Huang, Guodong Zhou, Yiqun Xiao, Nan Ji, Yuan-Ting Zhang, Ni Zhao
Journal: npj Digital Medicine (2023)

Abstract Cardiovascular diseases (CVDs) are a leading cause of death worldwide. For early diagnosis, intervention and management of CVDs, it is highly desirable to frequently monitor blood pressure (BP), a vital sign closely related to CVDs, during people’s daily life, including sleep time. Towards this end, wearable and cuffless BP extraction methods have been extensively researched in recent years as part of the mobile healthcare initiative. This review focuses on the enabling technologies for wearable and cuffless BP monitoring platforms, covering both the emerging flexible sensor designs and BP extraction algorithms. Based on the signal type, the sensing devices are classified into electrical, optical, and mechanical sensors, and the state-of-the-art material choices, fabrication methods, and performances of each type of sensor are briefly reviewed. In the model part of the review, contemporary algorithmic BP estimation methods for beat-to-beat BP measurements and continuous BP waveform extraction are introduced. Mainstream approaches, such as pulse transit time-based analytical models and machine learning methods, are compared in terms of their input modalities, features, implementation algorithms, and performances. The review sheds light on the interdisciplinary research opportunities to combine the latest innovations in the sensor and signal processing research fields to achieve a new generation of cuffless BP measurement devices with improved wearability, reliability, and accuracy.