tbuckley/cabot-search huggingface dataset:
In vitro germ cell induction from fertile and infertile monozygotic twin research participants
Authors: Erica C. Pandolfi, Fei-Man Hsu, Mark Duhon, Yi Zheng, Sierra Goldsmith, Jianping Fu, Sherman J. Silber, Amander T. Clark
Journal: Cell Reports Medicine (2022)

Human induced pluripotent stem cells (hiPSCs) enable reproductive diseases to be studied when the reproductive health of the participant is known. In this study, monozygotic (MZ) monoamniotic (MA) twins discordant for primary ovarian insufficiency (POI) consent to research to address the hypothesis that discordant POI is due to a shared primordial germ cell (PGC) progenitor pool. If this is the case, reprogramming the twin's skin cells to hiPSCs is expected to restore equivalent germ cell competency to the twins hiPSCs. Following reprogramming, the infertile MA twin's cells are capable of generating human PGC-like cells (hPGCLCs) and amniotic sac-like structures equivalent to her fertile twin sister. Using these hiPSCs together with genome sequencing, our data suggest that POI in the infertile twin is not due to a genetic barrier to amnion or germ cell formation and support the hypothesis that during gestation, amniotic PGCs are likely disproportionately allocated to the fertile twin with embryo splitting.
Different priming states of synaptic vesicles underlie distinct release probabilities at hippocampal excitatory synapses
Authors: Mohammad Aldahabi, Flora Balint, Noemi Holderith, Andrea Lorincz, Maria Reva, Zoltan Nusser
Journal: Neuron (2022)

A stunning example of synaptic diversity is the postsynaptic target cell-type-dependent difference in synaptic efficacy in cortical networks. Here, we show that CA1 pyramidal cell (PC) to fast spiking interneuron (FSIN) connections have 10-fold larger release probability (Pv) than those on oriens lacunosum-moleculare (O-LM) interneurons. Freeze-fracture immunolabeling revealed that different nano-topologies and coupling distances between Ca2+ channels and release sites (RSs) are not responsible for the distinct Pv. Although [Ca2+] transients are 40% larger in FSINs innervating boutons, when [Ca2+] entry is matched in the two bouton populations, EPSCs in O-LM cells are still 7-fold smaller. However, application of a phorbol ester analog resulted in a ∼2.5-fold larger augmentation at PC – O-LM compared to PC – FSIN synapses, suggesting incomplete docking or priming of vesicles. Similar densities of docked vesicles rule out distinct RS occupancies and demonstrate that incompletely primed, but docked, vesicles limit the output of PC – O-LM synapses.
Right in time: Mitapivat for the treatment of anemia in α- and β-thalassemia
Authors: Khaled M. Musallam, Ali T. Taher, Maria Domenica Cappellini
Journal: Cell Reports Medicine (2022)

Kuo and colleagues1 evaluated the safety and efficacy of mitapivat, an oral pyruvate kinase activator, in adults with non-transfusion-dependent α-thalassemia or β-thalassemia. The high rate of hemoglobin response and good tolerability encourages further development in thalassemia.
Advisory Board and Contents
Authors: Ruth Monk, Andrew Whitehouse, Hannah Waddington, Swetha Murthy, Nahman-Averbuch Hadas, Christopher King, Samantha Abram, Jessica Hua, Judith Ford, Patrick Drew, Jordan O'byrne, Karim Jerbi, Joaquin Migeot, Claudia Duran-Aniotz, Camilo Signorelli, Olivier Piguet, Agustín Ibáñez, Antonio Fernandez-Ruiz, Azahara Oliva, Hongyu Chang, Lucy Brooks, Holly Simpson, Scott Hill, Melanie Clements, Simona Parrinello, Moran Furman, Danielle Loughlin, Fred Kop, Patrick Scheffmann, Silvia Arber, Emery Brown, Rui Costa, Ann Craig, John Cryan, Catherine Dulac, Yukiko Goda, Kenneth Harris, Nancy Ip, Meyer Jackson, Maria Karayiorgou, Nancy Kopell, Robert Malenka, Mark Mattson, Freda Miller, Richard Morris, Maiken Nedergaard, Eric Nestler, Kia Nobre, Marco Prinz, Anna Wang, Roe Carmen, Sandi Klaas, Enno Stephan, Greg Stuart, Christopher Walsh, Xiaoqin Wang, Xu Zhang
Journal: Trends in Neurosciences (2022)
Simple interventions that make a huge difference: the consultant geriatrician
Authors: Kathy Oxtoby
Journal: BMJ (2022)

huge difference: the consultant geriatrician Amit Arora talks to Kathy Oxtoby about his love of teaching trainees and how he is drawn to healthcare innovation Kathy OxtobyIt's not just the complex nature of his work that satisfies consultant geriatrician Amit Arora, it's also about introducing simple but transformative measures that benefit patients.
Correction to: Functional classification of RUNX1 variants in familial platelet disorder with associated myeloid malignancies
Authors: Melanie Decker, Tim Lammens, Alina Ferster, Miriam Erlacher, Ayami Yoshimi, Charlotte M. Niemeyer, Martijn P. T. Ernst, Marc H. G. P. Raaijmakers, Nicolas Duployez, Andreas Flaum, Doris Steinemann, Brigitte Schlegelberger, Thomas Illig, Tim Ripperger
Journal: Leukemia (2022)
Improving the Diagnostic Yield of High-Resolution Esophageal Manometry for GERD: The “Straight Leg-Raise” International Study
Authors: Stefano Siboni, Ivan Kristo, Benjamin D. Rogers, Nicola De Bortoli, Anthony Hobson, Brian Louie, Yeong Yeh Lee, Vincent Tee, Salvatore Tolone, Elisa Marabotto, Pierfrancesco Visaggi, Jordan Haworth, Megan Ivy, Garrett Greenan, Chiara Facchini, Takahiro Masuda, Fumiaki Yano, Kyle Perry, Gokulakrishnan Balasubramanian, Dimitrios Theodorou, Tania Triantafyllou, Lorenzo Cusmai, Sara Boveri, Sebastian F. Schoppmann, C. Prakash Gyawali, Luigi Bonavina
Journal: Clinical Gastroenterology and Hepatology (2022)

The straight leg raise (SLR) maneuver during high-resolution manometry (HRM) can assess esophagogastric junction (EGJ) barrier function by measuring changes in intraesophageal pressure (IEP) when intra-abdominal pressure is increased. We aimed to determine whether increased esophageal pressure during SLR predicts pathologic esophageal acid exposure time (AET).Adult patients with persistent gastroesophageal reflux disease (GERD) symptoms undergoing HRM and pH-impedance or wireless pH study off proton pump inhibitor were prospectively studied between July 2021 and March 2022. After the HRM Chicago 4.0 protocol, patients were requested to elevate 1 leg at 45º for 5 seconds while supine. The SLR maneuver was considered effective when intra-abdominal pressure increased by 50%. IEPs were recorded 5 cm above the lower esophageal sphincter at baseline and during SLR. GERD was defined as AET greater than 6%.The SLR was effective in 295 patients (81%), 115 (39%) of whom had an AET greater than 6%. Hiatal hernia (EGJ type 2 or 3) was seen in 135 (46%) patients. Compared with patients with an AET less than 6%, peak IEP during SLR was significantly higher in the GERD group (29.7 vs 13.9 mm Hg; P < .001). Using receiver operating characteristic analysis, an increase of 11 mm Hg of peak IEP from baseline during SLR was the optimal cut-off value to predict an AET greater than 6% (area under the receiver operating characteristic curve, 0.84; sensitivity, 79%; and specificity, 85%), regardless of the presence of hiatal hernia. On multivariable analysis, an IEP pressure increase during the SLR maneuver, EGJ contractile integral, EGJ subtype 2, and EGJ subtype 3, were found to be significant predictors of AET greater than 6% CONCLUSIONS: The SLR maneuver can predict abnormal an AET, thereby increasing the diagnostic value of HRM when GERD is suspected.gov ID: NCT04813029.
Adenoma Detection Rate and Clinical Characteristics Influence Advanced Neoplasia Risk After Colorectal Polypectomy
Authors: Samir Gupta, Ashley Earles, Ranier Bustamante, Olga V. Patterson, Andrew J. Gawron, Tonya R. Kaltenbach, Hanin Yassin, Mark Lamm, Shailja C. Shah, Sameer Dev Saini, Deborah A. Fisher, Maria Elena Martinez, Karen Messer, Joshua Demb, Lin Liu
Journal: Clinical Gastroenterology and Hepatology (2022)

Postpolypectomy risk stratification for subsequent metachronous advanced neoplasia (MAN) is imprecise and does not account for colonoscopist adenoma detection rate (ADR). Our aim was to assess association of ADR with MAN and create a prediction model for postpolypectomy risk stratification incorporating ADR and other factors.We conducted a retrospective cohort study of individuals with baseline polypectomy and subsequent surveillance colonoscopy from 2004 to 2016 within the U.S. Department of Veterans Affairs (VA). Clinical factors, polyp findings, and baseline colonoscopist ADR were considered for the model. Model performance (sensitivity, specificity, and area under the curve) for identifying individuals with MAN was compared with 2020 U.S. Multi-Society Task Force on Colorectal Cancer (USMSTF) surveillance recommendations.A total of 30,897 individuals were randomly assigned 2:1 into independent model training and validation sets. Increasing age, male sex, diabetes, current smoking, adenoma number, polyp location, adenoma ≥10 mm or with tubulovillous/villous features, and decreasing colonoscopist ADR were independently associated with MAN. A range of 1.48- to 1.66-fold increased risk for MAN was observed for ADR in the lowest 3 quintiles (ADR <19.7%-39.3%) vs the highest quintile (ADR >47.0%). When the final model selected based on the training set was applied to the validation set, improved sensitivity and specificity over 2020 USMSTF risk stratification were achieved (P = .001), with an area under the curve of 0.62 (95% confidence interval, 0.60-0.64).Colonoscopist ADR is associated with MAN. Combining clinical factors and ADR for risk stratification has potential to improve postpolypectomy risk stratification. Improving ADR is likely to improve postpolypectomy outcomes.
Association of Antibodies to <i>Prevotella copri</i> in Anti–Cyclic Citrullinated <scp>Peptide‐Positive</scp> Individuals At Risk of Developing Rheumatoid Arthritis and in Patients With Early or Established Rheumatoid Arthritis
Authors: Jennifer A. Seifert, Elizabeth A. Bemis, Kristina Ramsden, Cassidy Lowell, Kristen Polinski, Marie Feser, Chelsie Fleischer, M. Kristen Demoruelle, Jane Buckner, Peter K. Gregersen, Richard M. Keating, Ted R. Mikuls, James R. O'Dell, Michael H. Weisman, Kevin D. Deane, Jill M. Norris, Allen C. Steere, V. Michael Holers
Journal: Arthritis & Rheumatology (2022)

Prevotella copri (P copri), a gut commensal, has been reported to be an immune-relevant organism in individuals with rheumatoid arthritis (RA). This study sought to evaluate anti-P copri (anti-Pc) antibody responses in our participant cohorts and to determine when in the natural history of RA such responses develop.
Tumor buster - where will the CAR-T cell therapy ‘missile’ go?
Authors: Chunrun Qu, Hao Zhang, Hui Cao, Lanhua Tang, Haoyang Mo, Fangkun Liu, Liyang Zhang, Zhenjie Yi, Lifu Long, Luzhe Yan, Zeyu Wang, Nan Zhang, Peng Luo, Jian Zhang, Zaoqu Liu, Weijie Ye, Zhixiong Liu, Quan Cheng
Journal: Molecular Cancer (2022)

Abstract Chimeric antigen receptor (CAR) T cell (CAR-T cell) therapy based on gene editing technology represents a significant breakthrough in personalized immunotherapy for human cancer. This strategy uses genetic modification to enable T cells to target tumor-specific antigens, attack specific cancer cells, and bypass tumor cell apoptosis avoidance mechanisms to some extent. This method has been extensively used to treat hematologic diseases, but the therapeutic effect in solid tumors is not ideal. Tumor antigen escape, treatment-related toxicity, and the immunosuppressive tumor microenvironment (TME) limit their use of it. Target selection is the most critical aspect in determining the prognosis of patients receiving this treatment. This review provides a comprehensive summary of all therapeutic targets used in the clinic or shown promising potential. We summarize CAR-T cell therapies’ clinical trials, applications, research frontiers, and limitations in treating different cancers. We also explore coping strategies when encountering sub-optimal tumor-associated antigens (TAA) or TAA loss. Moreover, the importance of CAR-T cell therapy in cancer immunotherapy is emphasized.
COP27 Climate Change Conference: Urgent action needed for Africa and the world
Authors: Lukoye Atwoli, Gregory E Erhabor, Aiah A Gbakima, Abraham Haileamlak, Jean-Marie Kayembe Ntumba, James Kigera, Laurie Laybourn-Langton, Robert Mash, Joy Muhia, Fhumulani Mavis Mulaudzi, David Ofori-Adjei, Friday Okonofua, Arash Rashidian, Maha El- Adawy, Siaka Sidibé, Abdelmadjid Snouber, James Tumwine, Mohammad Sahar Yassien, Paul Yonga, Lilia Zakhama, Chris Zielinski
Journal: The Lancet Regional Health - Europe (2022)
Sprayable Antibacterial Hydrogels by Simply Mixing of Aminoglycoside Antibiotics and Cellulose Nanocrystals for the Treatment of Infected Wounds (Adv. Healthcare Mater. 20/2022)
Authors: Lin Li, Xuejing Cheng, Quan Huang, Yiyun Cheng, Jianru Xiao, Jingjing Hu
Journal: Advanced Healthcare Materials (2022)

Smart Hydrogels Article 2201286 by Yiyun Cheng, Jianru Xiao, Jingjing Hu, and co-workers, reports a type of smart hydrogel by simply mixing aminoglycoside antibiotics and cellulose nanocrystals. The prepared hydrogels show excellent rheological behavior and allow facile administration by spraying. In addition, the gels exhibit efficient antibacterial activity both in vitro and in vivo and accelerate the healing of bacteria infected wounds.
Small Extracellular Vesicles Secreted by Nigrostriatal Astrocytes Rescue Cell Death and Preserve Mitochondrial Function in Parkinson's Disease (Adv. Healthcare Mater. 20/2022)
Authors: Loredana Leggio, Francesca L'Episcopo, Andrea Magrì, María José Ulloa‐Navas, Greta Paternò, Silvia Vivarelli, Carlos A. P. Bastos, Cataldo Tirolo, Nunzio Testa, Salvatore Caniglia, Pierpaolo Risiglione, Fabrizio Pappalardo, Alessandro Serra, Patricia García‐Tárraga, Nuno Faria, Jonathan J. Powell, Luca Peruzzotti‐Jametti, Stefano Pluchino, José Manuel García‐Verdugo, Angela Messina, Bianca Marchetti, Nunzio Iraci
Journal: Advanced Healthcare Materials (2022)
Engineering H<sub>2</sub>O<sub>2</sub> and O<sub>2</sub> Self‐Supplying Nanoreactor to Conduct Synergistic Chemiexcited Photodynamic and Calcium‐Overloaded Therapy in Orthotopic Hepatic Tumors (Adv. Healthcare Mater. 20/2022)
Authors: Ying‐Chi Chen, Yu‐Ju Liu, Chin‐Lai Lee, Khang‐Yen Pham, Divinah Manoharan, Suresh Thangudu, Chia‐Hao Su, Chen‐Sheng Yeh
Journal: Advanced Healthcare Materials (2022)

Photodynamic Therapies In article 2201613 by Chia-Hao Su, Chen-Sheng Yeh, and co-workers, the concept of self-supplying H2O2 and O2 is presented by an all-in-one nanoreactor to process H2O2 and O2 generation, chemiluminescence resonance energy transfer (CRET) activated by the generated H2O2, and energy-transfer to excite photosensitizer resulting in singlet oxygen formation. This allows the conduction of an external light-fee CRET-mediated photodynamic therapy, ushering in a new era in light-based therapeutic interventions.
COP27 Climate Change Conference: urgent action needed for Africa and the world
Authors: Lukoye Atwoli, Gregory E Erhabor, Aiah A Gbakima, Abraham Haileamlak, Jean-Marie Kayembe Ntumba, James Kigera, Laurie Laybourn-Langton, Robert Mash, Joy Muhia, Fhumulani Mavis Mulaudzi, David Ofori-Adjei, Friday Okonofua, Arash Rashidian, Maha El-Adawy, Siaka Sidibé, Abdelmadjid Snouber, James Tumwine, Mohammad Sahar Yassien, Paul Yonga, Lilia Zakhama, Chris Zielinski
Journal: The Lancet Planetary Health (2022)

Wealthy nations must step up support for Africa and vulnerable countries in addressing past, present, and future impacts of climate change. The 2022 report of the Intergovernmental Panel on Climate Change paints a dark picture of the future of life on earth, characterised by ecosystem collapse, species extinction, and climate hazards such as heatwaves and floods.1 These are all linked to physical and mental health problems, with direct and indirect consequences of increased morbidity and mortality.
COP27 Climate Change Conference: urgent action needed for Africa and the world
Authors: Lukoye Atwoli, Gregory E Erhabor, Aiah A Gbakima, Abraham Haileamlak, Jean-Marie Kayembe Ntumba, James Kigera, Laurie Laybourn-Langton, Robert Mash, Joy Muhia, Fhumulani Mavis Mulaudzi, David Ofori-Adjei, Friday Okonofua, Arash Rashidian, Maha El-Adawy, Siaka Sidibé, Abdelmadjid Snouber, James Tumwine, Mohammad Sahar Yassien, Paul Yonga, Lilia Zakhama, Chris Zielinski
Journal: The Lancet Public Health (2022)

Wealthy nations must step up support for Africa and vulnerable countries in addressing past, present, and future impacts of climate change. The 2022 report of the Intergovernmental Panel on Climate Change paints a dark picture of the future of life on earth, characterised by ecosystem collapse, species extinction, and climate hazards such as heatwaves and floods.1 These are all linked to physical and mental health problems, with direct and indirect consequences of increased morbidity and mortality.
Editorial Board
Authors: Clarence Loeb, Arthur Proetz, William Wherry, William Benedict, W Morrison, Stanley Truhlsen, Paul Henkind, Paul Lichter, Donald Minckler, Andrew Schachat, George Bartley, Stephen Mcleod, Russell Van Gelder, Seattle Wa, Daniel Albert, St Simons, Creig Hoyt, San Francisco
Journal: Ophthalmology (2022)
Contents
Authors: Golnoush Mahmoudinezhad, Takashi Nishida, Robert Weinreb, Sally Baxter, Medi Eslani, Eleonora Micheletti, Jeffrey Liebmann, Massimo Fazio, Christopher Girkin, Linda Zangwill, Sasan Moghimi, Xiangui He, Padmaja Sankaridurg, Jingjing Wang, Jun Chen, Thomas Naduvilath, Mingguang He, Zhuoting Zhu, Wayne Li, Ian Morgan, Shuyu Xiong, Jianfeng Zhu, Haidong Zou, Kathryn Rose, Bo Zhang, Rebecca Weng, Serge Resnikoff, Xun Xu, Yandong Bian, Kevin Ma, Nathan Hall, Tobias Elze, Alice Lorch, Joan Miller, Reza Dana, Jia Yin, Andrea Waksmunski, Tyler Kinzy, Lauren Cruz, Cari Nealon, Christopher Halladay, Piana Scm, Rachael Simpson, Scott Canania, David Anthony, Lea Roncone, Jenna Rogers, Jacquelyn Leber, Paul Dougherty, Jack Greenberg, Wen-Chih Wu, Sudha Iyengar, Dana Crawford, Neal Peachey
Journal: Ophthalmology (2022)
Microfluidized Dextran Microgels Loaded with Cisplatin/SPION Lipid Nanotherapeutics for Local Colon Cancer Treatment via Oral Administration (Adv. Healthcare Mater. 20/2022)
Authors: I.‐Lin Lu, Ting‐Wei Yu, Te‐I Liu, Hsin‐Hung Chen, Ying‐Chieh Yang, Chun‐Liang Lo, Chi‐Ya Wang, Hsin‐Cheng Chiu
Journal: Advanced Healthcare Materials (2022)

Nanomedicines In article 2201140 by Hsin-Cheng Chiu and co-workers, an oral polysaccharide microgel formulation containing dual-modality therapeutic nanoparticles developed for local treatment of colon cancer is imparted to hierarchical targeting residues, leading to increases in colon retention and cancer cell uptake of nanotherapeutics. With enzymatic degradation of dextran microgels occurring exclusively in the colon, the nanotherapeutics internalized by colon cancer cells exhibit sound anticancer effects.
Interfacing Perforated Eardrums with Graphene‐Based Membranes for Broadband Hearing Recovery (Adv. Healthcare Mater. 20/2022)
Authors: Chunyan Li, Zhiyuan Xiong, Lei Zhou, Weiluo Huang, Yushi He, Linpeng Li, Haibo Shi, Jiayu Lu, Jian Wang, Dan Li, Shankai Yin
Journal: Advanced Healthcare Materials (2022)

Eardrum Perforation In article 2201471 by Jiayu Lu, Dan Li, Shankai Yin, and co-workers, multilayered reduced graphene oxide membranes, offering a combination of exceptional mechanical strength, stiffness, lightweight and biocompatibility, are demonstrated to be a unique patching material to enable the closure of perforated eardrums of rats and complete restoration of broadband hearing.
Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight
Authors: Vitor Ferreira, Cintia Folgueira, Maria Guillén, Pablo Zubiaur, Marcos Navares, Assel Sarsenbayeva, Pilar López-Larrubia, Jan W. Eriksson, Maria J. Pereira, Francisco Abad-Santos, Guadalupe Sabio, Patricia Rada, Ángela M. Valverde
Journal: Metabolism (2022)

Second-generation antipsychotics (SGAs) are a mainstay therapy for schizophrenia. SGA-treated patients present higher risk for weight gain, dyslipidemia and hyperglycemia. Herein, we evaluated the effects of olanzapine (OLA), widely prescribed SGA, in mice focusing on changes in body weight and energy balance. We further explored OLA effects in protein tyrosine phosphatase-1B deficient (PTP1B-KO) mice, a preclinical model of leptin hypersensitivity protected against obesity.Wild-type (WT) and PTP1B-KO mice were fed an OLA-supplemented diet (5 mg/kg/day, 7 months) or treated with OLA via intraperitoneal (i.p.) injection or by oral gavage (10 mg/kg/day, 8 weeks). Readouts of the crosstalk between hypothalamus and brown or subcutaneous white adipose tissue (BAT and iWAT, respectively) were assessed. The effects of intrahypothalamic administration of OLA with adenoviruses expressing constitutive active AMPKα1 in mice were also analyzed.Both WT and PTP1B-KO mice receiving OLA-supplemented diet presented hyperphagia, but weight gain was enhanced only in WT mice. Unexpectedly, all mice receiving OLA via i.p. lost weight without changes in food intake, but with increased energy expenditure (EE). In these mice, reduced hypothalamic AMPK phosphorylation concurred with elevations in UCP-1 and temperature in BAT. These effects were also found by intrahypothalamic OLA injection and were abolished by constitutive activation of AMPK in the hypothalamus. Additionally, OLA i.p. treatment was associated with enhanced Tyrosine Hydroxylase (TH)-positive innervation and less sympathetic neuron-associated macrophages in iWAT. Both central and i.p. OLA injections increased UCP-1 and TH in iWAT, an effect also prevented by hypothalamic AMPK activation. By contrast, in mice fed an OLA-supplemented diet, BAT thermogenesis was only enhanced in those lacking PTP1B. Our results shed light for the first time that a threshold of OLA levels reaching the hypothalamus is required to activate the hypothalamus BAT/iWAT axis and, therefore, avoid weight gain.Our results have unraveled an unexpected metabolic rewiring controlled by hypothalamic AMPK that avoids weight gain in male mice treated i.p. with OLA by activating BAT thermogenesis and iWAT browning and a potential benefit of PTP1B inhibition against OLA-induced weight gain upon oral treatment.
Sponge‐Like Macroporous Hydrogel with Antibacterial and ROS Scavenging Capabilities for Diabetic Wound Regeneration (Adv. Healthcare Mater. 20/2022)
Authors: Cheng Wei, Pengfei Tang, Youhong Tang, Laibao Liu, Xiong Lu, Kun Yang, Qingyuan Wang, Wei Feng, Quazi T. H. Shubhra, Zhenming Wang, Hongping Zhang
Journal: Advanced Healthcare Materials (2022)

Macro-Porous Hydrogels In article 2200717 by Zhenming Wang, Hongping Zhang, and co-workers, a novel sponge-like macro-porous hydrogel with stable macro-porous structures is developed via a facile, fast approach induced by Ti3C2 MXene additives. It not only shows good antioxidant and antibacterial properties but also shows good material exchange capacity due to the interconnected pore structure. All these advantages provide the sponge-like hydrogel with a potential application for promoting the repair of diabetic wounds.