tbuckley/cabot-search huggingface dataset:
SOME CURRENT VIEWS ON INFANT FEEDING
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: A sub-population of high proliferative potential-quiescent human mesenchymal stem cells is under the reversible control of interferon α/β
Authors: I Peiffer, P Eid, R Barbet, M L Li, R A J Oostendorp, V Haydont, M-N Monier, L Milon, N Fortunel, P Charbord, M Tovey, J Hatzfeld, A Hatzfeld
Journal: Leukemia (2007)
Malaria
Authors: Quentin M. Geiman
Journal: New England Journal of Medicine (1948)

Transfusion MalariaUnexpected clinical malaria has occurred in many nonendemic malarious areas when patients receive transfusions of blood from donors who had previously lived or had been exposed to infection in endemic malarious areas.54 55 56 57 58 In New England the majority of such cases of transfusion malaria before World War II resulted from transfusions from adults who had previously lived in the Mediterranean area. With few exceptions, quartan malaria was the type that was contracted by the recipients of such donor blood. Rubenstein et al.59 recorded some of these cases, which were reported to the Massachusetts Department of Public Health. In the . . .
SARS-CoV-2 Vaccine–Induced Immune Thrombotic Thrombocytopenia
Journal: New England Journal of Medicine (2021)

In the paragraph beginning, "Additional cases" (page 2), the first sentence should have read, "Additional cases have now been reported to the European Medicines Agency, including at least 169 possible cases of cerebral venous sinus thrombosis and 53 possible cases of splanchnic vein thrombosis among 34 million recipients of the ChAdOx1 nCoV-19 vaccine, 35 possible cases of central nervous system thrombosis among 54 million recipients of the Pfizer-BioNTech mRNA vaccine, and 5 possible (but unvetted) cases of cerebral venous sinus thrombosis among 4 million recipients of the Moderna mRNA vaccine," rather than ". . .35 possible cases of central nervous system thrombosis among 54 million recipients of the Ad26.COV2.S adenoviral vector vaccine (Johnson & Johnson/Janssen), and 5 possible (but unvetted) cases of cerebral venous sinus thrombosis among 4 million recipients of the Moderna mRNA vaccine; no cases have been reported thus far with the Pfizer-BioNTech mRNA vaccine."An additional sentence should have followed: "Six possible cases of cerebral venous sinus thrombosis (with or without splanchnic vein thrombosis) have been reported among the more than 7 million recipients of the Johnson & Johnson/Janssen Ad26.COV2.S adenoviral vector vaccine."The article is correct at NEJM.org.
The role of a purinergic P2z receptor in calcium-dependent cell killing of isolated rat hepatocytes by extracellular adenosine triphosphate
Authors: J Zoetewij
Journal: Hepatology (1996)

Extracellular adenosine triphosphate (ATPo) (0.4 mmol/L), a P2-purinergic receptor agonist, induces cytolysis in several cell types including isolated rat hepatocytes. In this study, we investigated the P2-receptor involved in ATPo-induced, Ca2+-dependent cytotoxicity in hepatocytes. Pretreatment of hepatocytes with oxidized ATP, a P2z-receptor antagonist, or complexation of ATP4− (the agonist for the P2z-receptor) with an excess of Mg2+, prevented ATPo-induced cell death. Both protective treatments also prevented the development of a sustained high intracellular Ca2+ concentration as well as the subsequent accumulation of inorganic phosphate (Pi). The P2z-receptor agonist 3′-O-'(4-benzoylbenzoyl)-ATP (BzATP) was twofold more potent than ATP in eliciting cytolysis, which was preceded by a sustained high intracellular Ca2+ concentration; pretreatment with oxidized ATP prevented both the increase in the intracellular Ca2+ concentration and cell death. Prevention of ATPo-induced cell death, as well as the increases in the intracellular Ca2+ concentration and inorganic phosphate (Pi) was also achieved by decreasing the pHo to 6.9. Together the findings indicate that Ca2+-dependent cell killing by extracellular ATP in hepatocytes is mediated by a P2z-receptor. The cytolytic effects correlated specifically with a secondary “late” increase in the intracellular Ca2+ concentration.
Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms
Authors: Olga Barreiro, Moreno Zamai, María Yáñez-Mó, Emilio Tejera, Pedro López-Romero, Peter N. Monk, Enrico Gratton, Valeria R. Caiolfa, Francisco Sánchez-Madrid
Journal: The Journal of Experimental Medicine (2008)
20P Verification of mechanism that CSC markers are implicated in poor prognosis for pancreatic ductal adenocarcinoma
Authors: K. Arima, T. Ishimoto, M. Ohmuraya, H. Okabe, Y. Kitano, K. Yamamura, T. Kaida, S. Nakagawa, K. Imai, D. Hashimoto, A. Chikamoto, Y-I. Yamashita, H. Baba
Journal: Annals of Oncology (2016)
Poet's Corner
Authors: Irene Warsaw
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Breast cancer: minimalists, maximalists, other neoplasms
Authors: Martin H. Cohen, Robert G. Somers
Journal: JAMA (1991)

<h3>To the Editor. —</h3> The appropriateness of minimal or extensive surveillance of patients treated for stages I and II breast cancer recurrence was debated in a recent issue ofThe Journal.<sup>1,2</sup>Both points of view were well presented so that physicians have sufficient information to make judgments on this issue. Unfortunately, breast cancer recurrence may be only the second most important worry of these women. Risk of dying of a nonmammary, second primary neoplasm may exceed, in some subgroups, the risk of dying of breast cancer.<sup>3</sup>Everyone agrees that yearly mammography is important to detect local recurrences and new breast primary tumors.<sup>1,2</sup>Considered less often are planned efforts to detect endometrial, cervical, ovarian, colorectal, gastric, oral, and thyroid malignant neoplasms. Each of these neoplasms occurs with greater-than-expected frequency (relative risk, approximately 1.3 to 2.0) in patients with breast cancer.<sup>4-6</sup>The frequencyof development of nonmammary
Automatic external defibrillators used by emergency medical technicians. A controlled clinical trial
Authors: R. O. Cummins
Journal: JAMA (1987)

In a randomized controlled clinical trial, the effectiveness of emergency medical technician (EMT) use of automatic external defibrillators (AEDs) was compared with EMT use of standard defibrillators for patients in cardiac arrest. A total of 321 cardiac arrest patients were treated during the study: 116 were treated by EMTs using the AED (AUTO group), 158 were treated by EMTs using the standard defibrillators (standard group), and 47 were treated by EMTs using the standard defibrillator when they were assigned to use the AED. There were no significant differences in hospital admission or discharge rates between the AUTO group (54% admitted, 28% discharged) and the standard group (52% admitted, 23% discharged) for patients in ventricular fibrillation (VF), for patients in non-VF rhythms, or for all patients combined. The only significant difference observed was in the time from power ON to first shock: 1.1 minutes average AUTO group and 2.0 minutes average standard group. The treatment groups did not differ significantly in sensitivity for VF (78%AED, 76% standard), specificity for non-VF rhythms (100% AED, 95% standard), or rates of defibrillation to a non-VF rhythm (62% AED, 57% standard). We conclude that in clinical outcomes and device performance, AEDs are comparable with standard defibrillators and should be considered an acceptable alternative. Automatic external defibrillators appear to have advantages over standard defibrillators in training, skill retention, and faster operation. Such devices can make early defibrillation available for a much larger portion of the population. They are a major innovation for the prehospital care of cardiac arrest patients. (<i>JAMA</i>1987;257:1605-1610)
Clinical Diabetes Mellitus: A Problem-Oriented Approach
Authors: David L. Horwitz
Journal: JAMA (1992)

Dust-induced diseases have been recognized since antiquity: medieval lapidaties died of them, as did countless miners, stonecutters, and metal polishers. With the development of steam- and, later, gasoline-powered machinery early in the 20th century, however, workers in such trades were exposed to dramatically increased levels of dust. The result was a minor epidemic of dust-induced diseases, notably silicosis, that aroused both popular and medical attention in the 1920s and 1930s. came increasingly concerned about "consumption" around the turn of the century, especially after steam-driven equipment replaced hand drills and sledgehammers. Granite cutters complained that the new equipment raised unhealthy levels of dust, a charge that epidemiological studies eventually corroborated (a 1934 study showed that granite cutters were dying of tuberculosis at rates up to ten times higher than was average for males in Massachusetts). In November 1909, granite cutters near Barre, Vt, voted to refuse to use the "man killer"
England Imposes 72-Hour Limit on Residents
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Respiratory Epithelium. IV. Histogenesis of Epidermoid Metaplasia and Carcinoma In Situ in the Hamster&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Peter J. Becci, Ph.D., Elizabeth M. McDowell, B. Vet. Med., Ph.D., Benjamin F. Trump, M.D.
 6
Journal: JNCI Journal of the National Cancer Institute (1978)

The histogenesis of epidermoid metaplasia and carcinoma in situ was studied in female hamster tracheobronchial epithelium during and after 15 weekly intratracheal instillations of a benzo[a]pyrene-ferric oxide (BP-Fe2O3) mixture in saline. Within 24 hours after the first instillation of BP-Fe2O3, goblet cell hyperplasia had occurred. Mitoses were observed in small mucous granule cells (SMGC). SMGC probably represent mature mucous cells at early stages of their secretory cycle. Ciliated cells were extruded, and by 1 week after the first instillation the epithelium was repopulated with mucous cells. During 1–5 weeks the mucosubstances in these cells became more acidic, and the epithelium was composed of more than one cuboidal mucous cell layer. At 1 week after the fifth carcinogen instillation, the epithelium was composed of basal cells and metaplastic cuboidal and flattened surface mucous cells (epidermoid metaplasia). Extensive keratinization occurred at 10 weeks (cornifying epidermoid metaplasia). The luminal cornifying epidermoid cells contained periodic acid-Schifff-positive, diastase-resistant mucosubstances. Localized areas of marked atypical metaplasia and carcinoma in situ were observed 20–50 weeks after the first instillation. They were characterized by one to two layers of basal cells and five to ten layers of pleomorphic cuboidal cells. The surface cells had all the characteristics of mucous cells, and cells near the basal lamina showed features of epidermoid cells. Mucus-filled intraepithelial cysts were observed. These data support the hypothesis of conversion of mucous cells to metaplastic and neoplastic cells.
Nederlands Tijdschr Geneeskunde, Amsterdam
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Les Sourds-Muets en Norvege. La Surdi-Mutité, sa Distribution, ses Causes ses Symptoms. Son Rapport avec les Unions Consanguines, Conditions Sociales des Sourds-Muets; avec Remarques sur la Diagnose, la Prophylaxie et le Traitement de la Surdi-Mutite.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Awakenings
Authors: Barry I. Liskow
Journal: JAMA (1974)

In<i>Awakenings</i>, a humanistic physician provides a compassionate account of his observations over a five-year period (1967 to 1972) of postencephalitic parkinsonian patients and their strange and often tragic reactions when treated with levodopa. The author's various digressions add to an already interesting book. He gives a concise history of the influenza epidemic (1918 to 1926) that led to these patients' eventual illness, along with evidence that such epidemics have occurred frequently in the past and are very likely to recur. In addition, interspersed among his case histories, Sacks includes his observations of the deleterious effects on patients when institutions for the chronically ill are run for efficiency rather than for human needs. However, going far beyond the individual case descriptions, the book reaches substantial depth in its final chapters and the copious footnotes that accompany the 20 case histories. These detail the philosophical implications as Sacks draws on the
Adrenal function ablation utilizing the angiographic catheter
Authors: J. W. Lecky
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The valine catabolic pathway in human liver: Effect of cirrhosis on enzyme activities
Authors: K Taniguchi
Journal: Hepatology (1996)

The activities of key enzymes in the valine catabolic pathway–branched-chain aminotransferase, branched-chain alpha-keto acid dehydrogenase complex, methacrylyl (MC)-coenzyme A (CoA) hydratase (crotonase), and 3- hydroxyisobutyryl-CoA (HIB-CoA) hydrolase–were measured in normal and cirrhotic human livers. Unlike rat liver, which does not contain branched-chain aminotransferase, the aminotransferase activity in the normal liver was measurable and is increased somewhat in cirrhosis of the human liver. The total activity of branched-chain alpha-keto acid dehydrogenase complex in the normal human liver was approximately 1% of that in rat liver, and 20% to 30% of the complex was in the active form in both normal and cirrhotic livers. Only the actual activity of the enzyme was significantly decreased by cirrhosis. These results suggest that human liver is less active than rat liver in the catabolism of branched-chain amino and alpha-keto acids. Activities of MC-CoA hydratase and HIB-CoA hydrolase in human liver were very high compared with that of branched-chain alpha-keto acid dehydrogenase complex, suggesting an important role for these enzymes in catabolism of a potentially toxic compound, MC-CoA, formed as an intermediate in the catabolism of valine and isobutyrate. Cirrhosis resulted in a significant decrease in HIB-CoA hydrolase activity but had no effect on the citrate synthase activity, suggesting that the decrease in HIB-CoA hydrolase activity does not reflect a general decrease in mitochondria but that it may contribute to cellular damage that culminates in liver failure.
RECONSTRUCTION OF HARD PALATE WITH CARTILAGE TRANSPLANT
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Pill
Authors: Robert B. Greenblatt
Journal: JAMA (1966)

<h3>To the Editor:—</h3> A plea was made, "let's be honest with the pill." Regretfully, the manner in which the data were presented left room for wholly unwarranted conclusions. Thus, unintentionally perhaps, they were less than honest with "the pill." For example, of 24 patients seven received injectable medroxyprogesterone acetate—six of them for threatened abortion and one for irregular menses. This potent, longacting progestational agent is useful if employed in the management of endometriosis or metastatic endometrial carcinoma. There are few, if any, other indications. It should not be used indiscriminately because prolonged amenorrhea as well as prolonged withdrawal bleeding may follow... It is my considered opinion that this report was misleading. The inconsistencies are glaring, the choice of histological description, unfortunate. Let's not becloud the great benefits to be derived from the judicious use of orally administered contraceptives by magnifying and distorting the minor complications of therapy.