tbuckley/cabot-search huggingface dataset:
HCV: Pathogenesis
Journal: Hepatology (2013)

severity of disease as investigated by ALT and bilirubin levels.Similarily, gender and HCV-genotype were not associated with HADS scores.Sustained virological response did not influence HADS-A and HADS-D.HADS data from 8 of 21 patients (38%) who were lost to follow-up before the end of therapy were available, only one of these patients had an HADS-A and HADS-D above 8 at baseline.Conclusion: Symptoms of anxiety and depression are frequent in patients with symptomatic and asymptomatic acute HCV infection and are independent of the severity of disease.However, HADS does not seem to be associated with lost to follow-up both in immediate as well as in delayed treatment.
PTU-131 Oesophageal Thermal Sensitivity and Mucosal Integrity in Healthy Subjects. A Study using a Novel Peltier-Based Heating Device and Impedance
Authors: M Al-Zinaty, P Woodland, J Reeves, M Birch, Q Aziz, D Sifrim
Journal: Gut (2013)

<h3>Introduction</h3> Investigation of oesophageal sensitivity might help better improve phenotyping of patients with GERD, functional heartburn and non-obstructive dysphagia. Studies on oesophageal thermal sensitivity have used balloon techniques with circulating water. This lacks linear control of heating, has relative heat loss, and provokes mechanical stimulation by the distended balloon. Oesophageal mucosal integrity is important in symptoms perception and can be studied using impedance “in vivo”. We developed a catheter device incorporating a “thermal stimulator” using Peltier heating technology and impedance electrodes to assess mucosal contact and integrity. We <b>aimed</b> to investigate oesophageal heat sensation/pain thresholds and their relationship with mucosal integrity in healthy human subjects. <h3>Methods</h3> 21 healthy volunteers underwent thermal stimulation using an oesophageal catheter with a 7 mm electronic Peltier heater, to deliver a ramp heating protocol up to 60°C at 5 and 15 cm above LOS. Symptoms were recorded by computerised Visual Analogue Score (VAS). The delivered temperature at Pain Detection Threshold (PDT), time to PDT was measured and the area under the heating curve (AUC) was calculated. Oesophageal impedance was assessed over 10 minutes pre (basal), during and post heating in the distal and proximal oesophagus. The protocol was repeated after 2 weeks to assess reproducibility. <h3>Results</h3> Temperature at PDT showed a very low SD in the distal and proximal oesophagus and Bland-Altman Tests showed good reproducibility (–0.1905 95% CI –1.4132 to 1.0327). There were no significant differences in thermal sensitivity parameters between distal and proximal oesophagus. Due to the low inter-individual variability in thermal sensitivity between healthy subjects, we could not find a significant correlation between impedance and perception parameters in the proximal or distal oesophagus. <h3>Conclusion</h3> A novel Peltier-based thermal stimulator device can accurately and reproducibly determine oesophageal thermal sensitivity. In healthy subjects we could not demonstrate a correlation between basal impedance and sensitivity to heating. Current experiments are assessing this correlation in NERD patients with hypersensitivity to acid. <h3>Disclosure of Interest</h3> None Declared
Progress Toward the Elimination of Tuberculosis—United States, 1998
Journal: JAMA (1999)

In 1998, a total of 18,361 tuberculosis (TB) cases were reported from the 50 states and the District of Columbia, a decrease of 8% from 1997 and 31% from 1992, the height of the TB resurgence in the United States. The 1998 rate of 6.8 per 100,000 population was 35% lower than in 1992 (10.5) but remained above the national goal for 2000 of 3.5. This report summarizes national TB surveillance data for 1998 and compares them with similar data from previous years. The findings indicate that the overall number of TB cases continued to decrease, and that trends in the number of reported cases and TB incidence varied by geographic area and population characteristics.
Erratum: Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation
Authors: Mariana Toricelli, Fabiana H. M. Melo, Giovani B. Peres, Débora C. P. Silva, Miriam G. Jasiulionis
Journal: Molecular Cancer (2015)

After publication of this study [1], we found out that we unfortunately sent two figures in duplicate.They are Fig.4b NT and Fig. 6c NT [1].It is important to emphasize that the results shown in the graphs are correct since they represent the mean of three independent biological assays, each of them made in technical triplicates.The photographs are only representative figures of three biological assays.
Eleven peak flow meters: a clinical evaluation
Authors: H Folgering, W vd Brink, O v Heeswijk, C v Herwaarden
Journal: European Respiratory Journal (1998)

Peak flow meters are essential tools in the management of asthma. Many types are on the market. A computer-driven piston pump is normally not available for evaluation of the various meters. Comparison with values from a pneumotachograph is an accepted way of testing peak flow meters. This study aims at comparing 11 peak flow meters, for accuracy and linearity. Seven adult peak flow meters were tested: Miniwright with an equidistant scale (Clement Clarke); Personal Best (Healthscan); Wright Pocket fdE (Ferraris); Vitalograph (Vitalograph); Assess (Healthscan); Pocket Peak flow meter (Micro Medical); and Truzone (Monaghan). Furthermore, four low-range (LR) peak flow meters were tested: LR Miniwright with equidistant scale (Clement Clarke); LR Personal Best (Healthscan); LR Wright Pocket (LR Ferraris); and LR Pocket peak flow meter (LR Micro Medical). Two test series were performed: in the first one, a peak flow meter was connected downstream in series with a Fleisch #4 pneumotachograph. One subject performed 50 partial forced expiratory manoeuvres through this ensemble. In the second series, 50 adult patients and 25 healthy children performed sequential maximal forced expiratory manoeuvres on each peak flow meter, and on the pneumotachograph. A ranking system was devised for the various parameters of agreement of the meters with the pneumotachograph. Substantial differences in the quality of the adult meters were found. The adult peak flow meters with the closest agreement to the pneumotachograph were Personal Best and Micro Medical. In the low-range peak flow meters, the lowest differences were seen in the LR Personal Best and LR Micro Medical.
Familial Melanomas
Authors: Morton J. Robinson
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Robertson (<b>217</b>:1553, 1971) in a husband and wife, and Bauman (<b>217</b>:1300, 1971) in stepbrothers raised in the same household, have recorded the contemporaneous occurrence of familial melanoma in nonblood-related individuals. These reports raise the question of coincidental association contagion (Marshall,<b>218</b>:1831, 1971). We have recently encountered this association in a husband and wife who had been married and living together for 47 years. Patient 1 was a 73-year-old man seen for evaluation of a lesion of the left chest wall of one year's duration. Three weeks prior to the first visit, he noticed a nodule in the corresponding axilla, where a purplish, papillary lesion arose from the edge of a nevus, 1.5 cm in size, in the area of the left breast. There was a palpable node, 3 cm in size, at the base of the left axilla. A presumptive diagnosis of melanoma was
Highlights
Journal: JAMA Pediatrics (2019)

Albuterol Premedication and Respiratory Adverse Events 527von Ungern-Sternberg and colleagues conducted a randomized clinical trial of 479 children undergoing tonsillectomy.They found that perioperative respiratory adverse events were observed in 67 of 241 children (27.8%) receiving albuterol and 114 of 238 (47.9%) receiving placebo.Laryngospasm, coughing, and oxygen desaturation each occurred significantly more often in the placebo group.Albuterol premedication should be considered when planning anesthesia for children undergoing tonsillectomy alongside other strategies for reducing the risk of perioperative respiratory adverse events in this high-risk population.Continuing Medical Education jamanetwork.com/learning Effect of Gastric Residual Evaluation on Enteral Intake 534Parker and colleagues conducted a randomized clinical trial of 143 premature, very lowbirth-weight infants and found that those who did not undergo gastric residual evaluation advanced feeds more quickly and consumed more enteral nutrition at weeks 5 and 6 after birth.Among extremely preterm infants, the omission of gastric residual evaluation was safe and increased the delivery of enteral nutrition.
Commentaire de travail de W. H. Choe et al., pp. 649
Journal: Endoscopy (2011)

See also: Comparison of transnasal small-caliber vs. peroral conventional esophagogastroduodenoscopy for evaluating varices in unsedated cirrhotic patientsEndoscopy 2011; 43(08): 649-656DOI: 10.1055/s-0030-1256474
Immunogenicity of inactivated parainfluenza type 1, type 2, and type 3 vaccines in infants
Authors: H. W. Kim
Journal: JAMA (1966)

Inactivated viral vaccines for parainfluenza virus types 1, 2, and 3 were prepared in embryonated hens' eggs, type 1 in the allantoic cavity, types 2 and 3 in the amniotic sac. The vaccines were given to 36 young infants, 28 of whom lacked neutralizing antibody for the virus corresponding to the vaccine administered. Ten infants received parainfluenza 1, ten received parainfluenza 2, and 16 received parainfluenza 3 vaccine. All infants received two injections at an interval of one month, and each infant given the parainfluenza 1 and 3 vaccines received an additional injection 41 to 163 days after the second injection. These vaccines were 90% to 100% effective in inducing a neutralizing antibody response. The infants given parainfluenza 2 vaccine responded following two injections, whereas a majority of those given parainfluenza 1 and 3 vaccines required an additional injection at a later time. Repeated freezing and thawing appeared to inactivate the serum neutralizing activity induced by type 2 vaccine.
Peritoneovenous (LeVeen) shunt. Control of renin-aldosterone system in cirrhotic ascites
Authors: M. H. Witte
Journal: JAMA (1978)

Because of the unusual clinical course of a patient with hepatic cirrhosis, refractory ascites, and hepatorenal syndrome, we were able to examine the complex interrelationships between massive ascites, renin-aldosterone activity, and renal and hepatic function before and after placement of a peritoneojugular vein (LeVeen) shunt. Measurements indicated that when the shunt was functioning, renin-aldosterone production was suppressed, the hepatorenal syndrome was reversed, and ascites remitted. These data suggest that hyperreninemia, hyperaldosteronism, and functional renal abnormalities of this disorder are potentially reversible and arise primarily from the imbalance between formation and drainage of hepatosplanchnic lymph rather than from hepatocellular dysfunction, lowered plasma oncotic pressure, or portal hypertension. (<i>JAMA</i>239:31-33, 1978)
Prescription Drug Prices in the US
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Studies in a hyperthyroid subject after hypophysectomy
Authors: R. Grinberg
Journal: JAMA (1966)

Studies were carried out in a hyperthyroid patient before, during, and after hypophysectomy as follows: (1) Levels of protein-bound iodine (PBI), butanol-extractable iodine serum (BEI), cholesterol, and<sup>131</sup>I uptake were the clinical measurements chosen to evaluate the function of the thyroid gland. (2) Metabolic studies were conducted after the administration of thyroxine I 131 and sodium iodide I 131. (3) Levels of thyrotropic hormone (TSH) and long-acting thyroid stimulator (LATS) in the serum provided information about pituitary function. (4) Detailed histopathologic studies of the brain, midbrain, pituitary, pituitary stalk, median eminence, and thyroid gland were performed. (5) Serial sections of the sella turcica revealed that the hypophysectomy was total. This study revealed that the thyroid gland of the patient was able to increase the<sup>131</sup>I uptake, maintain a normal PBI level and incorporate<sup>131</sup>I into organ systems several months after hypophysectomy. Chromatographic studies of the pituitary gland after the administration of thyroxine I 131 showed iodine, tetraiodothyronine and triiodothyronine. The median eminence and hypothalamic areas were histologically normal.
Infectivity and Pathogenicity of Indian and British Tubercle Bacilli
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3069: Reduction of Left Ventricular Dyssynchrony after Catheter Ablation for Isolated Permanent Atrial Fibrillation in Patients with Depressed Left Ventricular Function
Authors: Patricia Reant, Stephane Lafitte, Frederic Sacher, Nicolas Derval, Stephanie Brette, Meleze Hocini, Herve Douard, Jacques Clementy, Michel Haissaguerre, Raymond Roudaut, Pierre Jais
Journal: Circulation (2007)

Background: Persistent/Permanent atrial fibrillation (Per AF) and electromechanical left ventricular (LV) dyssynchrony are frequently associated in patients with systolic heart failure. Their relationships have not been investigated yet. Objective: We hypothesized that Per AF could induce or worsen ventricular dyssynchrony. The aim of this prospective study was to evaluate the degree of LV dyssynchrony in patients with Per AF and depressed LV function; to describe the evolution of dyssynchrony after AF catheter ablation. Methods: 28 patients with isolated Per AF and depressed LV function were investigated with a VIVID7 (General Electric) before ablation (D-1), at 1 month (M+1) and at 6 month (M+6) after the procedure and compared to 28 controls. LV ejection fraction was evaluated by biplane Simpson rule. LV dyssynchrony was quantified by tissue Doppler imaging in apical views using a triplane 3D/4D acquisition. Maximal difference between times to peak (mdTP) was determined. TP was measured as the delays between the onset of the QRS and the peak velocity of systolic wave on the 6 basal LV segments. Values were averaged on 3 consecutive cardiac cycles. LV dyssynchrony was defined for a mdTP value &gt;65ms. Parameters of dyssynchrony were normalized to RR interval. Results: Before ablation, mdTP was &gt;65ms for 10 (36%) of the patients (group1) and &gt;65ms for 18 patients (group 2). Ejection fraction was significantly lower in group 1 than in group 2. During the follow-up, the LV ejection fraction increase was similar in the 2 groups (+42%; +41%)(Table ). In the whole population, mdTP decreased from 57.5±35ms to 44.1±35ms (P&lt;0.05). However, the LV dyssynchrony improvement was much more marked in group 1 than in group 2 (−42%; −13%). Conclusions: In this study, LV dyssynchrony was present in 36% of the patients with permanent AF and impaired LV ejection fraction. Catheter ablation significantly improved both LV ejection fraction and LV dyssynchrony in this population. Table
Twenty-Fourth Annual Colloquium on Protides of the Biological Fluids
Journal: JNCI Journal of the National Cancer Institute (1976)

Journal Article Twenty-Fourth Annual Colloquium on Protides of the Biological Fluids Get access JNCI: Journal of the National Cancer Institute, Volume 56, Issue 1, January 1976, Page 201, https://doi.org/10.1093/jnci/56.1.201-e Published: 01 January 1976
Book Review Goodman and Gilman's The Pharmacologic Basis of Therapeutics, Ninth Edition CD-ROM, Edited by Joel G. Hardmann and Lee E. Limbird, with Perry B. Molinoff, Raymond W. Ruddon, and Alfred Goodman Gilman. System needed: Multimedia IBM PC or compatible computer with 4 MB RAM and at least 6 MB hard-disk space. (Also available for Macintosh System 7.0 or higher, with 4 MB RAM and at least 4 MB free hard-disk space.) New York, McGraw-Hill, 1997. $95. 0-07-864186-1 The Merck Index, 12th …
Authors: Eytan Z. Blumenthal, Daniel Mimouni
Journal: New England Journal of Medicine (1997)
DNA Adducts and Related Biomarkers in Populations Exposed to Environmental Carcinogens
Authors: Frederica Perera, Diane Brenner, Alan Jeffrey, Jack Mayer, Deliang Tang, Dorothy Warburton, Tie-Ian Young, Leila Wazneh, Louise Latriano, Grazyna Motykiewicz, Ewa Grzybowska, Mieczyslaw Chorazy, Kari Hemminki, Regina Santella
Journal: Environmental Health Perspectives (1992)

Prevention of environmentally related cancer will be enhanced by the availability of sensitive early warning systems and by improvements in quantitative assessment of human risks. Accordingly, we have carried out a series of molecular epidemiologic studies aimed at validating a panel of biologic markers, including carcinogen–DNA and –protein adducts, sister chromatid exchange, micronucleus formation, DNA strand breaks, and DNA repair capacity. Results from three such studies illustrate the usefulness of these biomarkers in elucidating low-dose–response relationships, correlations between biomarkers, and the range of variation in biomarkers between individuals exposed to similar concentrations of carcinogens. Low-level workplace or ambient exposures to styrene, ethylene oxide, and polycyclic aromatic hydrocarbons (PAH) were associated with significant increases in both molecular dose of carcinogens (adducts) and various markers of preclinical effects. Correlations between biomarkers varied by exposure. For example, in the styrene study, sister chromatid exchange frequency was not correlated with any of the markers, in contrast to the studies of ethylene oxide and PAH. Significant molecular effects were observed not only in occupationally exposed people but also in residents of an area in Poland characterized by high levels of air pollution. For example, the mean PAH–DNA level in exposed residents (winter sample) was 30.4 adducts per 108 nucleotides. This level was significantly higher than that of adducts seen in summer samples from the same area (4.2/108), or in winter samples from residents of a rural area (11.01/108). Significant seasonal variation in PAH–DNA adduct formation in this group was consistent with recorded fluctuations in air pollution levels. Striking interindividual variation was observed in all three exposed populations.
Article on Mesenchymal Stem Cell Targeting of Microscopic Tumors
Journal: Clinical Cancer Research (2006)

In the article on mesenchymald stem cell targeting of microscopic tumors in the November 1, 2005 issue of Clinical Cancer Research, in the Materials and Methods section, in the Tumor Cells paragraph, the correct concentrations of penicillin and streptomycin are 100 units/mL and 100 ug/mL, respectively.In the Results section, in the Microscopic Analyses of Tumor Stroma and Surrounding Tissues paragraph, the second sentence should read, as follows: In the first group of mice with s.c. coinjection of tumor cells and tracer TG-hMSCs, as well as in the second group with i.v. administration of tracer TG-hMSCs, the EGFP fluorescence and immunostaining were detectable mainly in cells forming the capillary-like structures (Fig. 2G, H, and I), in the cells within the inner layer of small arterioles (Fig. 3B, C, E, and F), and in connective tissue cells (Fig. 2F). The last sentence in this section should read, as follows: In particular, EGFP-expressing cells were identified in hair follicles (Fig 2A, B, C, and D), in the basal layer of dermis (Fig. 3A and D), and in the endothelial and intimal layers of small blood vessels in the skin overlaying s.c. tumors.Hung S-C, Deng W-P, Yang WK, et al. Mesenchymal stem cell targeting of microscopic tumors and tumor stroma development monitored by noninvasive in vivo positron emission tomography imaging. Clin Cancer Res 2005;11:7749–56.
Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of patients with mixed‐lineage‐leukemia‐rearranged acute leukemia: results from a prospective, multi‐center study
Authors: Rydz Natalia, Jayne Leggo, Tinlin Shawn, James Paula, Lillicrap David, Natalia Rydz, Shawn Tinlin, Paula James, David Lillicrap, Wang Yu, Liu Qi-Fa, Qin Ya-Zhen, Liu Dai-Hong, Xu Lan-Ping, Jiang Bin, Jiang Qian, Dai Min, Yu Si-Jian, Jiang Xin-Miao, Huang Xiao-Jun, Yu Wang, Qi-Fa Liu, Ya-Zhen Qin, Dai-Hong Liu, Lan-Ping Xu, Bin Jiang, Qian Jiang, Min Dai, Si-Jian Yu, Xin-Miao Jiang, Yan-Rong Liu, Xiao-Jun Huang, Dean Campagna, Charlotte De Bie, Klaus Schmitz-Abe, Marion Sweeney, Anoop Sendamarai, Paul Schmidt, Matthew Heeney, Helger Yntema, Caroline Kannengiesser, Bernard Grandchamp, Charlotte Niemeyer, V Knoers, Sonia Swart, Gordon Marron, Richard Van Wijk, Reinier Raymakers, Alison May, Kyriacos Markianos, Sylvia Bottomley, Dorine Swinkels, Mark Fleming
Journal: American Journal of Hematology (2014)

The creatinine value in Table 1 Definition of Myeloma in these three articles should read "0.173 mmol/L" instead of "1.73 mmol/L".The value in conventional units given in parenthesis is correct.We apologize for any confusion this error might have caused.