Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care System
Authors: Tim B. Bigdeli, Georgios Voloudakis, Peter B. Barr, Bryan R. Gorman, Giulio Genovese, Roseann E. Peterson, David E. Burstein, Vlad I. Velicu, Yuli Li, Rishab Gupta, Manuel Mattheisen, Simone Tomasi, Nallakkandi Rajeevan, Frederick Sayward, Krishnan Radhakrishnan, Sundar Natarajan, Anil K. Malhotra, Yunling Shi, Hongyu Zhao, Thomas R. Kosten, John Concato, Timothy J. O’Leary, Ronald Przygodzki, Theresa Gleason, Saiju Pyarajan, Mary Brophy, Grant D. Huang, Sumitra Muralidhar, J. Michael Gaziano, Mihaela Aslan, Ayman H. Fanous, Philip D. Harvey, Panos Roussos, Mihaela Aslan, M Antonelli, M de Asis, MS Bauer, Mary Brophy, John Concato, F Cunningham, R Freedman, Michael Gaziano, Theresa Gleason, Philip Harvey, Grant Huang, J Kelsoe, Thomas Kosten, T Lehner, JB Lohr, SR Marder, P Miller, Timothy O Leary, T Patterson, P Peduzzi, Ronald Przygodski, Larry Siever, P Sklar, S Strakowski, Hongyu Zhao, Ayman Fanous, W Farwell, A Malhorta, S Mane, P Palacios, Tim Bigdeli, M Corsey, L Zaluda, Juanita Johnson, Melyssa Sueiro, D Cavaliere, V Jeanpaul, Alysia Maffucci, L Mancini, J Deen, G Muldoon, Stacey Whitbourne, J Canive, L Adamson, L Calais, G Fuldauer, R Kushner, G Toney, M Lackey, A Mank, N Mahdavi, G Villarreal, EC Muly, F Amin, M Dent, J Wold, B Fischer, A Elliott, C Felix, G Gill, PE Parker, C Logan, J McAlpine, LE DeLisi, SG Reece, MB Hammer, D Agbor-Tabie, W Goodson, M Aslam, M Grainger, Neil Richtand, Alexander Rybalsky, R Al Jurdi, E Boeckman, T Natividad, D Smith, M Stewart, S Torres, Z Zhao, A Mayeda, A Green, J Hofstetter, S Ngombu, MK Scott, A Strasburger, J Sumner, G Paschall, J Mucciarelli, R Owen, S Theus, D Tompkins, SG Potkin, C Reist, M Novin, S Khalaghizadeh, Richard Douyon, Nita Kumar, Becky Martinez, SR Sponheim, TL Bender, HL Lucas, AM Lyon, MP Marggraf, LH Sorensen, CR Surerus, C Sison, J Amato, DR Johnson, N Pagan-Howard, LA Adler, S Alerpin, T Leon, KM Mattocks, N Araeva, JC Sullivan, T Suppes, K Bratcher, L Drag, EG Fischer, L Fujitani, S Gill, D Grimm, J Hoblyn, T Nguyen, E Nikolaev, L Shere, R Relova, A Vicencio, M Yip, I Hurford, S Acheampong, G Carfagno, GL Haas, C Appelt, E Brown, B Chakraborty, E Kelly, G Klima, S Steinhauer, RA Hurley, R Belle, D Eknoyan, K Johnson, J Lamotte, E Granholm, K Bradshaw, J Holden, RH Jones, T Le, IG Molina, M Peyton, I Ruiz, L Sally, A Tapp, S Devroy, V Jain, N Kilzieh, L Maus, K Miller, H Pope, A Wood, E Meyer, P Givens, PB Hicks, S Justice, K McNair, JL Pena, DF Tharp, L Davis, M Ban, L Cheatum, P Darr, W Grayson, J Munford, B Whitfield, E Wilson, SE Melnikoff, BL Schwartz, MA Tureson, D D Souza, K Forselius, M Ranganathan, L Rispoli, M Sather, C Colling, C Haakenson, D Kruegar, Sumitra Muralidhar, Rachel Ramoni, Jim Breeling, Kyong-Mi Chang, Christopher O Donnell, Philip Tsao, Jennifer Moser, Jessica Brewer, Stuart Warren, Dean Argyres, Brady Stevens, Donald Humphries, Nhan Do, Shahpoor Shayan, Xuan-Mai Nguyen, Saiju Pyarajan, Kelly Cho, Elizabeth Hauser, Yan Sun, Peter Wilson, Rachel McArdle, Louis Dellitalia, John Harley, Jeffrey Whittle
Journal: JAMA Psychiatry (2022)

Serious mental illnesses, including schizophrenia, bipolar disorder, and depression, are heritable, highly multifactorial disorders and major causes of disability worldwide.