tbuckley/cabot-search huggingface dataset:
Plasma Cell Leukemia in BALB/c Mice Inoculated With Subcellular Material. I. Incidence and Morphology&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Peter Ebbesen, Ragna Rask-Nielsen, K. Robert McIntire
Journal: JNCI Journal of the National Cancer Institute (1968)

Plasma cell leukemias have been induced in BALB/c mice after contact with a possible agent from (CBA × DBA/2)F1 mice with transplantable reticular neoplasms. The contact could be via subcellular extracts either directly from the F1 leukemic material or indirectly from tissues of DBA/2 or BALB/c mice which had received the F1 extract, but did not necessarily have recognizable neoplasia. The progeny of BALB/c females inoculated with the suspected leukemogenic agent also had an increased incidence of neoplasia. Inoculation into DBA/2 mice was followed by development of lymphocytic leukemia and some reticulosarcomas. The addition of liver tissue extract with hepatitis agent caused a greater increase in leukemia than the leukemogenic agent alone. The leukemias developed late in life at the same average age as the spontaneous reticular neoplasms of this strain. Since male mice died of amyloidosis before reaching this age, the incidence in males was low except after castration, which caused the males to live as long as females. Paraproteinemia was found in one-third of the mice with plasma cell leukemia. Transplantation of the tumors was successful in all 39 cases attempted.
Diphtheria in Russia a Reminder of Risk
Authors: Phil B. Fontanarosa
Journal: JAMA (1995)

THE ONGOING and expanding diphtheria epidemic occurring in the New Independent States (NIS) of the former Soviet Union is a vivid reminder that infectious diseases considered to be under control in developed countries carry the potential for resurgence and for causing significant morbidity and mortality. Moreover, this epidemic not only underscores the critical importance of routine periodic vaccinations for achieving and maintaining protective antibody levels, but also makes imminent the need for physicians in developed countries to be able to readily diagnose and treat a rarely seen disease. See also p 1250. Diphtheria is uncommon in the United States and in most developed countries that have successful immunization programs. According to Iain Hardy, MD, a medical epidemiologist in the National Immunization Program at the Centers For Disease Control and Prevention (CDC), "only 40 cases of diphtheria were reported in the United States from 1980 to 1992, with 70% occurring in
The Detection of Poisons and Strong Drugs, Including the Quantitative Estimation of Medicinal Principles in Certain Crude Materials.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Therapeutics. A Handbook on the Special Treatment of Internal Disease.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary complications of peritoneal access catheters.
Authors: G R Weiss
Journal: Journal of Clinical Oncology (1985)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1985.3.12.1690 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 4067617 Pulmonary complications of peritoneal access catheters. G R WeissxG R WeissSearch for articles by this author https://doi.org/10.1200/JCO.1985.3.12.1690 PDF "Pulmonary complications of peritoneal access catheters.." Journal of Clinical Oncology, 3(12), pp. 1690–1691© 1985 by American Society of Clinical Oncology
Soft tissue sarcoma of limbs: better outlook
Authors: Barbara Bolsen
Journal: JAMA (1981)

Investigators at the National Cancer Institute (NCI) report improved survival in patients with soft tissue sarcoma of the extremities as a result of treatment that includes surgery, radiation therapy, and chemotherapy. Soft tissue sarcomas are relatively rare but aggressive solid tumors, occurring most often in people in their 20s through 40s. About 5,000 cases occur each year, two thirds of them in the extremities. Traditional treatment (surgical excision of the tumor or amputation) has resulted in three- to five-year survival rates of about 40% in virtually all reported series, according to Steven A. Rosenberg, MD, chief, NCI surgery branch and principal investigator. But in clinical trials on 107 patients, Rosenberg and colleagues at NCI's radiation oncology and medicine branches obtained a three-year disease-free survival rate of 91% and an overall three-year survival rate of 93% among patients receiving the combination therapy. The three-year results are promising because 80% of all
POS0167 A PROTEOGENOMIC MAP OF NATURAL KILLER CELLS IN OLIGOARTICULAR JUVENILE IDIOPATHIC ARTHRITIS
Authors: O. Knight, G. Guerra, M. F. Mashreghi, T. Kallinich, T. Rückert, C. Romagnani
Journal: Annals of the Rheumatic Diseases (2022)

Background Natural Killer (NK) cells are innate lymphocytes which are specialised for recognising stressed cells, classically divided into cytotoxic (CD56dim) and cytokine-producing (CD56bright) populations. During oligoarticular Juvenile Idiopathic Arthritis (oligo-JIA), an unknown trigger induces the recruitment of peripheral immune cells into synovial joints, which in turn creates a chronic inflammatory environment. This can result in joint contractures and extraarticular complications, highlighting the requirement for early disease intervention. The contribution of NK cells toward immunopathology during the early stages of disease and in subsequent arthritic flares is unknown, providing a potential avenue for understanding disease course and therapeutic intervention. Objectives We aimed to assess the contribution of NK cells to the early pathogenesis of oligo-JIA by identifying inflammatory signatures present in patient synovia, and which signals could induce them. Methods Peripheral blood (PB) and synovial fluid (SF) were drawn from 4 patients at the first clinical presentation of oligo-JIA. Flow-cytometry Activated Cell-Sorting (FACS) was used to unbiasedly isolate NK cells (CD3-CD7+), and single cell RNA-sequencing (scRNA-Seq) paired with oligonucleotide-tagged antibodies (CITE-Seq) performed, allowing us to generate a proteogenomic dataset of 35,609 NK cells. Antibody-derived-tags were used to delineate whether cells were isolated from PB or SF, and a community detection algorithm was used to cluster neighbours of cells for differential gene expression. Results We identified 468 differentially expressed genes (&gt;0.2 log2 fold change) between peripheral and synovial NK cells, among which were CD56bright- and CD56dim-specific genes, and a synovia-specific signature. Antibody-tag measurements confirmed the majority of synovial NK cells to be phenotypically CD56bright, with a spectrum of modified gene expression patterns compared of those in the periphery. 6 distinct synovial clusters were identified by community detection, among which were a large number of proliferating cells, a transitionary CD56bright population, and 2 uniquely activated signatures. Conclusion Synovial NK cells possess a significantly different transcriptomic identity compared with those in the periphery. However, though they share a gene signature that is most comparable to blood CD56bright NK cells, it is not identical. Uniquely activated subpopulations also provide the first evidence of NK cell activation during oligo-JIA pathogenesis, suggesting that these cells could hold therapeutic potential. Acknowledgements Stefanie Bartsch, Kathleen Necke, Carl-Christoph Goetzke, Anne Sae Lim von Stuckrad and all other members of the TargArt Consortium Disclosure of Interests None declared
Intra-abdominal Migration of an Antireflux Prosthesis
Authors: Ole A. Peloso
Journal: JAMA (1982)

Use of an antireflux prosthesis (Angelchik prosthesis) in the surgical treatment of symptomatic gastroesophageal reflux has increased steadily during the past several years. This report describes a patient in whom this device broke away from its insertion site at the cardioesophageal junction and migrated through the abdominal cavity to the pelvis. Variable abdominal and pelvic symptoms accompanied this passage, and abdominal roentgenograms identified the final pelvic location. Breakaway was caused by avulsion of the tie straps from the prosthesis. Four additional cases of migratory antireflux prostheses are reported briefly. Physicians should be aware that bizarre and otherwise unexplained abdominal pain in patients with this device may result from dislocation and migration of the prosthesis through the abdominal cavity. Abdominal roentgenograms are diagnostic and define the extent of migration. (<i>JAMA</i>1982;248:351-353)
The Internal Secretions of the Ovary.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Left Ventricular Asynergy in Acute Myocarditis
Authors: Premindra Anthony N. Chandraratna
Journal: JAMA (1983)

Recent studies have demonstrated the usefulness of two-dimensional echocardiography in the detection of regional wall abnormalities in acute myocardial infarction. We describe two patients with acute myocarditis who had acute chest pain simulating acute myocardial infarction. Two-dimensional echocardiography initially demonstrated regional wall motion abnormalities that disappeared within a few days. These two cases illustrate that regional wall motion abnormalities are not specific for acute myocardial infarction and that acute myocarditis may simulate acute myocardial infarction. (<i>JAMA</i>1983;250:1428-1430)
A Textbook of Materia Medica for Nurses.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Empyema Seven Years After Pneumonectomy
Authors: C. P. Kesavan Kutty
Journal: JAMA (1979)

EMPYEMA occurring days to weeks after pneumonectomy is usually diagnosed during the same hospitalization. A late-onset postpneumonectomy empyema may be very difficult to diagnose. In some cases, a new airfluid level appearing on the chest roentgenogram provides a lead to the diagnosis or an empyema necessitatis makes the diagnosis obvious.<sup>1</sup>In others, there may be no diagnostic clues. In such patients, a gallium 67 scan may detect empyema in the postpneumonectomy space. <h3>Report of a Case</h3> A 52-year-old man was admitted to the Wood (Wis) Veterans Administration Medical Center on Jan 17, 1978, with cough, shortness of breath, and chills of two weeks' duration. He also noted an elevated temperature of 40 °C orally on one occasion, blood-streaked sputum, and occasional left-sided chest pain on coughing. He had a right-sided pneumonectomy for a bronchial adenoma in 1971, without complications. In February 1976, he was hospitalized for ten days for
Possible Renal Complications of Acupuncture
Authors: William J. Keller
Journal: JAMA (1972)

<h3>To the Editor.—</h3> The recent surge of interest in acupuncture has led to a review of a case of renal lithiasis seen by us in 1967. The patient was a 50-year-old male Chinese. During the course of evaluation for hypertension, intravenous urography showed a calculus in the left renal pelvis encasing a metallic foreign body. Further history and examination indicated that the patient had been born in what is now the People's Republic of China, and lived there until the age of 18 years. While he cannot specifically recall having undergone acupuncture, he does know that acupuncture was practiced on family members about that time. The patient had a stellate, 2-cm scar on the left flank area in the anterior axillary line related to "an infection" in childhood. The general examination was otherwise unremarkable. A left nephrectomy was done in January 1967. In the renal pelvis, staghorn calculus, 3.5 ×
A Comparison of Western European and US University Hospitals
Authors: Steven A. Schroeder
Journal: JAMA (1984)

To assess how closely US university hospitals resemble those in other Western countries, I compared four major European university hospitals— Leuven, Belgium; Klinikum Steglitz, West Berlin; Leiden, the Netherlands; and St Thomas', London—with a US institution—University of California, San Francisco (UCSF). University of California had 1.6 to 2.4 more total employees, 1.1 to 1.7 more registered nurses, 2.1 to 8.5 more staff physicians, and 1.5 to 3.0 more house officers per adjusted occupied bed. University of California's costs per bed were 2.2 to 3.5 times higher, its inclusive per diem charges at least four times higher, and its malpractice premium at least 50 times greater. Medical patients at UCSF and West Berlin were more severely ill, as judged by organ system failure, need for organ system support, and levels of consciousness. Compared with UCSF, the European hospitals had more explicit rationing of care according to age and illness severity. Overall, European university hospitals are larger, less expensive, less technology intensive, staffed by fewer employees and physicians, occupied by less severely ill patients, and more apt to serve as regional referral centers. As US university hospitals move into a price-competitive era, they may come to resemble their European counterparts. (<i>JAMA</i>1984;252:240-246)
Cost of Antimicrobial Drugs in a Hospital
Authors: Hobart A. Reimann
Journal: JAMA (1968)

<h3>To the Editor:—</h3> A report published in 1966 listed what patients paid for antimicrobial drugs in a number of hospitals. In one 550-bed hospital, the cost to inpatients for one month was $15,273 or about $183,000 per year.<sup>1</sup>For the year 1967-1968, the cost had more than doubled to about $400,000, which accounted for 60% of the total bill for all drugs. The Table lists the percentages of the usual "mark-up" prices for various antimicrobial drugs dispensed last year by the hospital pharmacy. Antimicrobial usage increased despite admonition of numerous authorities for restraint in a therapy because of a rising incidence of iatrogenic sequels and of resistant microbes. Penicillin, still prescribed most often, was far exceeded in cost by cephalothin sodium and ampicillin sodium (Table). More ampicillin than cephalothin was dispensed, but the cost of cephalothin, which has no particular advantage over other agents,<sup>2</sup>was more than threefold
East-West efforts key into leprosy research
Authors: Victoria Schauf
Journal: JAMA (1984)

Leprosy, or Hansen's disease, is still a major health problem in the Orient. Efforts to control and eradicate this ancient disease began centuries ago with isolation programs. Substantial progress came in the 1940s and 1950s with the development of specific treatment regimens using sulfones, particularly dapsone. Nonetheless, experts estimate there are as many as 15 million leprosy patients worldwide. Even in the United States, the small number of reported cases is increasing owing to importations from developing countries (see accompanying story, page 18). The failure to eradicate leprosy is not readily explained. The disease, however, is most prevalent in countries with limited medical resources. Additionally, as many as 5% of patients infected with the etiologic agent,<i>Mycobacterium leprae</i>, now do not respond to dapsone therapy because of primary or secondary resistance. Hence, a vigorous international effort in prevention, detection, and treatment of leprosy is under way. The World Health Organization,
Disseminated Herpes Simplex With Encephalitis in a Neonate
Authors: Bruce Golden
Journal: JAMA (1969)

A premature baby had neonatal disseminated herpes simplex. Idoxuridine therapy was started when the infant was 12 days old and it was given intravenously for five days in a dose of 100 mg/kg/day. Clinical recurrence of the herpetic infection developed 20 days after the initial therapeutic course, and a second course of idoxuridine was successful in eradicating the virus.
Clinical Laboratory Technic for Nurses.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Skin Cancer in Immunosuppressed Patients
Authors: John C. Maize
Journal: JAMA (1977)

The development of malignant neoplasms in renal transplant recipients is a problem of considerable practical importance as well as biological interest. There is not, however, a simple, acrossthe-board increase in the incidence of all types of neoplasms, as would be expected if this was due solely to the suppression of host defense mechanisms against carcinomas. Skin cancers (39%) and lymphomas (27%) account for approximately two thirds of all cases recorded in the Denver Transplant Tumor Registry.<sup>1</sup>One explanation that has been offered for the increased incidence of lymphomas is that chronic antigenic stimulation of the host lymphoreticular system by the grafted tissue, which bears "nonself" histocompatibility antigens, may lead to the emergence of a neoplastic clone of lymphoid cells.<sup>2</sup>This would not account for the problem of cutaneous carcinomas. Here are other explanations for the increased incidence of neoplasms<sup>3-5</sup>: (1) immunosuppressive therapy impairs the "surveillance" function of