tbuckley/cabot-search huggingface dataset:
Psychopharmacology
Authors: Samuel Friedman
Journal: JAMA (1969)

In a scant 15 years psychopharmacology has come of age; this book confers upon it the mantle of maturity. A welcome relief from psychiatric cant and theory, it summarizes in magnificent scope our scientific knowledge of drugs currently available in psychiatric therapeutics. In some 450 double-columned pages, the history, chemical composition, physiological-pharmacological action, and clinical investigation of every pertinent drug have been superbly reviewed. In certain areas the experience of individual investigators may differ somewhat from some opinions expressed in this extensive presentation. For example, I have not found that the desmethylated compounds of imipramine or amitriptyline act more rapidly than their parent drugs. Nor have I been able definitely to correlate the ultimate response to the antidepressant drugs with their therapeutic action during the first week of administration, since their effect during that early period is usually quite negligible. My experience negates the use of these compounds in personality
THE TECHNIC OF PERCUSSION.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WHO recommendations on the composition of the 2015/16 influenza virus vaccines in the northern hemisphere
Authors: None Eurosurveillance editorial team
Journal: Eurosurveillance (2015)

Preview this article: WHO recommendations on the composition of the 2015/16 influenza virus vaccines in the northern hemisphere, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/20/9/art21048-en-1.gif
Systemic Mycoses
Authors: Thomas P. Kugelman
Journal: JAMA (1969)

This excellent symposium on diverse aspects of the deep or systemic mycoses is the product of a meeting by a group of the world's foremost mycologists in Ibadan, Nigeria, in March 1967. The 13 papers, grouped under general headings of pathology, clinical aspects, epidemiology, and therapy, include detailed discussions by the participants which follow each paper and conclude each section of the book. Although occasionally too long and tedious, the discussions will reward the patient reader with his share of "pearls." Mycoses prevalent in Africa, appropriately enough, receive special emphasis. No comparable source on the clinical and laboratory findings in African histoplasmosis is readily accessible elsewhere. The papers on mycetoma and phycomycosis also merit attention. This reader found three of the general review articles most rewarding: one on diagnostic serology and immunology by H. P. R. Seeliger; another on transmission, ecology, and epidemiology by L. Ajello; and, finally, one on
Surgery of the Musculoskeletal System
Authors: Irwin M. Siegel
Journal: JAMA (1991)

Have you ever noticed how some books seem to have a life of their own? With time, they grow, they age, and they even put on weight. Such is the case with<i>Surgery of the Musculoskeletal System</i>(first reviewed in<i>JAMA</i>[1984;252:1351-1352]), which in its second edition, at five volumes (5214 + pages), has almost reached critical mass. It could almost be<i>ein Deutsches Handbuch</i>, an oxymoron if ever there was one, as it is not per se a book and could never be held in one's hand. However, this seems the trend; other members of the genre have been planted rather than pruned in their later editings.<i>Campbell's Operative Orthopaedics</i>(CV Mosby Co, 1989), the parent of the species, matured to four volumes (3250 pages) in its seventh edition. Only the young<i>Chapman's Operative Orthopaedics</i>, (reviewed in<i>JAMA</i>[1989;261:1650]) is no fatter (still three volumes, 2293 pages) the second time
Forecasted State-Specific Estimates of Self-Reported Asthma Prevalence-- United States, 1998
Journal: JAMA (1999)

Asthma is a chronic inflammatory disorder of the lungs characterized by episodic and reversible symptoms of airflow obstruction. During 1993-1994, an estimated 13.7 million persons in the United States reported having asthma, and from 1980 to 1994 the prevalence of self-reported asthma in the United States increased 75%. Despite this increase, surveillance data are limited for asthma at the state and local levels. To estimate the 1998 prevalence rate of asthma for each state, CDC analyzed national self-reported asthma prevalence data from 1995. This report summarizes the results of the analyses, which project that approximately 17 million persons in the United States have asthma.
Neuro-ophthalmology
Journal: BMJ (1945)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Neuro-ophthalmology Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Effects of Dexfenfluramine on Hypoxic Pulmonary Vasoconstriction and Embolic Pulmonary Hypertension in Dogs
Authors: Robert Naeije, Pierre Wauthy, Marco Maggiorini, Marc Leeman, Marion Delcroix
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

There has been suggestion of a possible relationship between the intake of the appetite suppressant dexfenfluramine and the development of primary pulmonary hypertension. We investigated the pulmonary vascular effects of acute intravenous dexfenfluramine in pentobarbital-anesthetized dogs ventilated in hyperoxia (fraction of inspired oxygen, FiO2, 0.4) and either challenged with a FiO2 of 0.1 to induce hypoxic pulmonary hypertension (n = 20) or given autologous blood clots to induce embolic pulmonary hypertension (n = 6). Pulmonary vascular tone was evaluated by multipoint (mean pulmonary artery pressure [Ppa] - pulmonary artery occluded pressure [Ppao])/cardiac output () plots. Hypoxia increased Ppa - Ppao over the entire range of studied, from 1.5 to 4.0 L/min/m2, in 12 dogs (responders) and had no significant effect on (Ppa - Ppao)/ plots in 8 other dogs (nonresponders). Dexfenfluramine did not affect (Ppa - Ppao)/ plots in 6 responders but shifted (Ppa - Ppao)/ plots to higher pressures in hypoxia in 6 nonresponders (p < 0.001). Dexfenfluramine had no effect on (Ppa - Ppao)/ plots in the 6 dogs with embolic pulmonary hypertension. Because dexfenfluramine has serotoninergic properties, we compared the effects of ketanserin, a serotonin (5-hydroxytryptamine, 5-HT) S2 receptor antagonist, on naturally present versus dexfenfluramine-restored hypoxic pulmonary vasoconstriction. Ketanserin did not affect hyperoxic or hypoxic pulmonary vascular tone, neither in 6 responders nor in 2 nonresponders with dexfenfluramine-restored hypoxic vasoconstriction. We conclude that dexfenfluramine restores hypoxic pulmonary vasoconstriction in dogs with weak or absent hypoxic pressor response and that this effect is unlikely to be mediated by activation of 5-HT S2 receptors.
Abstract 799: Aberrant mitochondrial protein involvement through early PDAC initiation and progression using multiplexed DNA-PAINT and correlative histology
Authors: Matthew J. Rames, Fehmi Civitci, Ting Zheng, Josiah Wagner, Jason Link, Xiaolin Nan
Journal: Cancer Research (2019)

Abstract Prior to pancreatic ductal adenocarcinoma (PDAC), pancreatic acini cells change their morphology through pancreatic intraepithelial neoplasia (PanIN) stages, becoming increasingly dysplastic as stroma and tissue hypoxia increase. This increasing hypoxia forms a cancer promoting microenvironment, wherein we propose metabolic changes trigger aberrant mitochondrial networks form healthy tissue. We developed tissue superresolution imaging to directly quantify structural mitochondrial response through patient histology, whereby DNA-PAINT can provide super-resolution detail decoupled from photo bleaching to visualize mitochondria through tissue layers. Expanding from preliminary data, target mitochondrial dynamics proteins’ organization will also be correlated to PanIN stages. Introduction: Early oncogene involvement in PDAC progression links to metabolic and mitochondrial regulatory changes. Typically nutrient deprivation and hypoxia trigger cell death from increased reactive oxygen species production and organelle damage which trigger apoptosis, yet these prolonged effects can be cancer promoting when less severe. Mitochondrial dynamics and proteins related to mitochondrial fission and fusion can reduce apoptotic signaling, enhance aerobic glycolysis, and increase ROS to allow cancer progression. Materials and Methods: Adapting from previous proof of concept, mitochondria (TOM20) within formalin-fixed paraffin embedded (FFPE) tissue sections were imaged with stochastic optical reconstruction microscopy (STORM). In brief: cadaver healthy pancreas FFPE tissue samples underwent deparafinization, antigen retrieval, indirect immuno-labeling with AlexaFluor647, TIRF illumination with a 60x objective was used for data collection, whereby data processing was conducted using the open-source FIJI and custom MATLAB software. Results and Discussion: Preliminary data shows proof of principle that both STORM and DNA-PAINT can be correlated to histological staining of human pancreas. Conclusions: Superresolution imaging reveals ultrastructural details of mitochondria in FFPE patient samples not resolved via conventional fluorescence imaging. Through quantitative feature analysis, we would be able to correlate aberrant mitochondria structure and abundance to PDAC progression. Acknowledgements: Funding provided by the Cancer Early Detection Advanced Research (CEDAR) Center of OHSU Knight Cancer Institute. Citation Format: Matthew J. Rames, Fehmi Civitci, Ting Zheng, Josiah Wagner, Jason Link, Xiaolin Nan. Aberrant mitochondrial protein involvement through early PDAC initiation and progression using multiplexed DNA-PAINT and correlative histology [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 799.
THE GASTRIC JUICE IN BRIGHT'S DISEASE.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CME Hiatus: July Through December 2002
Authors: Suzanne Fletcher, Graham Colditz
Journal: JAMA (2002)

In Reply: We agree with Dr Cooper that the results of the WHI do not necessarily apply to women experiencing early natural menopause because the study included only women aged 50 to 79 years.However, the evidence regarding her suggestion that women undergoing early natural menopause may be at increased risk of cardiovascular disease is not clear.As Cooper points out, one study found an association between early age at menopause and increased risk for cardiovascular mortality. 1A later report from the Nurses' Health Study (and involving 1 of us, G.A.C.) found that this association was confined to current smokers; there was no increased cardiovascular risk among women who experienced early natural menopause but never smoked. 2 The association Cooper writes of therefore may be due to residual confounding by smoking, a behavior well known to be associated with both increased cardiovascular risk and early menopause and a behavior amenable to treatment.
Pheochromocytoma
Authors: Thep Himathongkam
Journal: JAMA (1974)

PHEOCHROMOCYTOMA is a rare catecholamine-secreting tumor usually of the adrenal medulla, but occasionally it arises in other neural crest-derived tissues. The clinical presentation is episodic or persistent hypertension associated with flushing, sweating, and tachycardia or cardiac arrhythmias. An acute hypertensive episode may be precipitated by exercise, ingestion of tyramine-containing compounds, external pressure on the tumor, anesthesia, monoamine oxidase inhibitor drugs, or surgery. The diagnosis can be confirmed by elevated urine levels of vanillylmandelic acid, metanephrines, and catecholamines.<sup>1,2</sup> <h3>Therapy</h3> The only definitive treatment of pheochromocytoma is surgical removal of the tumor. Therefore, the following discussion on therapy will emphasize the treatment of an<i>acute hypertensive episode</i>along with the medical management of the patient prior to and during surgery. <h3>Reduction of Blood Pressure During Acute Hypertensive Episode.—</h3> When a hypertensive patient is suspected of having a pheochromocytoma, the patient should be confined to bed, with the head elevated at a
A new biological marker for depression?
Authors: E. R. Gonzalez
Journal: JAMA (1983)

The standard for diagnosis of depression in the United States is the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (DSM-III). To ascertain which DSM criteria patients meet and to assess their symptoms, psychiatrists often rely on psychodiagnostic instruments such as the Beck Depression Inventory, the Zung Self-Rating Depression Scale, the Hamilton Depression Rating Scale, and the Schedule for Affective Disorders and Schizophrenia. Unfortunately, clinicians cannot yet base diagnoses on the results of objectively assessed physiological abnormalities (other than superficially observable phenomena, such as anorexia, psychomotor retardation, and early morning waking in some types of depression). Hence the quest for definitive biological "marker systems" continues. Perhaps the best-known system at present is the dexamethasone suppression test. On this assay, exogenous dexamethasone administration fails to suppress endogenous cortisol secretion in many different disease states, including some depressions. Another is the urinary assay for the major norepinephrine metabolite, 3-methoxy-4-hydroxyphenylglycol. Others
Section 37.—Syphilitic Arthritis
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Automatic Writing--A Correction
Journal: BMJ (1894)

a paragraph in the Pal Matt Gazette: "A Sane Man confined in a Madhouse."In it was alleged that a pauper, after some apparently rough usage in a work- house, was removed to Cane Hill Asylum.The person was carefully examined on admission by a resident plhysician, and was reported by him to be sane.Dr. Moody then went closely into the case, and formed the same opinion; not only so, but he revisited tlle patient hlimself at a later hour of the same evening, and confirmed his opinion of the patient's sanity.Dr. Moody, llowever very properly gave the poor
General Subcellular Effects of Lead, Mercury, Cadmium, and Arsenic
Authors: Bruce A. Fowler
Journal: Environmental Health Perspectives (1978)

This working paper summarizes the known ultrastructural and biochemical effects of lead, mercury, cadmium, and arsenic on subcellular organelle systems following in vivo administration. Documented metal-induced alterations in nuclear, mitochondrial, microsomal, and lysosomal functions are discussed in relation to their potential impact on cellular responses to other environmental agents. Each of the above elements has been found to interfere with normal cellular replication and genetic processes. Mitochondrial swelling and depression of respiratory function are discussed in relation to known metal-specific perturbations of mitochondrial heme biosynthetic pathway enzymes. Inhibition of microsomal enzyme activities and protein synthesis by lead and mercury is compared to the apparent absence of such effects following arsenic or cadmium exposure. Lysosomal uptake of all the metals is documented, but biochemical alterations in these structures have been reported for only mercury and cadmium. It is concluded that these toxic metals are capable of interacting with, and biochemically altering major cellular systems at dose levels below those required to produce signs of overt metal toxicity. The impact of these effects on cellular response to other metals and xenobiotics in complex exposure situations is presently unknown, and further research is urgently needed in this area.
COEDUCATION.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Neurology (2014)

Relapsing-Remitting MS After 24 Natalizumab Doses 954Clerico and colleagues evaluate the effect of therapeutic choices on the mean annualized relapse rate and on magnetic resonance imaging multiple sclerosis (MS) activity after 24 doses of natalizumab in patients with relapsing-remitting MS.The TY-STOP study recruited at 8 Italian MS centers 124 adult patients who demonstrated no clinical or magnetic resonance imaging MS activity after 24 doses of natalizumab.They report class III evidence of an increased risk of MS activity resumption after natalizumab discontinuation.
Learning about alcoholism: a "must' for physicians
Authors: P. Gunby
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acta Tuberc et Pneumol Scand, Copenhagen
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal