tbuckley/cabot-search huggingface dataset:
Breaking satellite silence: human satellite II RNA expression in ovarian cancer
Authors: Shridar Ganesan
Journal: Journal of Clinical Investigation (2022)

Multiple cancer types demonstrate abnormal expression of repetitive RNA sequences as a form of epigenetic instability. There is growing interest in understanding the role of repetitive RNAs in cancer pathogenesis and immunogenicity and in their potential role as diagnostic or therapeutic biomarkers. In this issue of the JCI, Porter and colleagues report on satellite RNA in a subset of ovarian cancers. The authors found that high expression of human satellite (HSAT) repeats - but not other families of repeats - was associated with an immunosuppressive phenotype in ovarian cancer cell lines and tumor samples. Further induction of HSAT RNA levels in vitro, surprisingly, leads to innate immune activation, suggesting a potential therapeutic strategy. This work highlights the expanding role of repetitive RNAs in tumor biology and the need to better define specific classes of repetitive elements expressed in cancer - as well as their role in tumorigenesis, tumor immunity, and the host response to cancer.
Long noncoding RNA BLACAT2 promotes bladder cancer–associated lymphangiogenesis and lymphatic metastasis
Authors: Wang He, Guangzheng Zhong, Ning Jiang, Bo Wang, Xinxiang Fan, Changhao Chen, Xu Chen, Jian Huang, Tianxin Lin
Journal: Journal of Clinical Investigation (2022)

The authors recently became aware of errors in Figure 9, B and C. In Figure 9B, the area indicated as magnified in the inset box was incorrect for the Vector/shControl/Anti-luciferase IHC image.In addition, Figure 9C contained an incorrect image for the Vector/shControl/ Intratumoral sample.The corrected figure panels are shown below.The authors regret the errors.
Aged glomeruli: a link between PD-1 and podocytes
Authors: Samuel Mon-Wei Yu, John Cijiang He
Journal: Journal of Clinical Investigation (2022)

Understanding the loss of kidney function resulting from kidney aging has become an emerging research focus that will facilitate the future development of antisenolytic treatments. In this issue of the JCI, Pippin et al. first identified PD-1 upregulation in the aged mouse podocyte via unbiased RNA-seq analysis. Overexpression of PD-1 in immortalized mouse podocytes induced cell death and a senescence-associated secretory phenotype, suggesting the pathological role of PD-1 upregulation in aged podocytes. Blocking PD-1 signaling via a neutralizing anti-PD-1 antibody reversed the aged phenotype in the aged mice and ameliorated proteinuria in an experimental focal segmental glomerulosclerosis (FSGS) mouse model. These findings highlight the role of PD-1 signaling in kidney aging and its therapeutic potential for human clinical trials.
Supercharged chimeric antigen receptor T cells in solid tumors
Authors: Ayush Pant, Christopher M. Jackson
Journal: Journal of Clinical Investigation (2022)

Chimeric antigen receptor (CAR) T cells have demonstrated success in treating select hematological malignancies, but their activity in solid tumors has been comparably modest. Challenges specific to treating solid tumors include trafficking and distribution throughout the tumor site, overcoming the immunosuppressive tumor microenvironment (TME), and identifying antigenic targets that are widely expressed and indispensable to tumor biology. In this issue of the JCI, Tian et al. describe the use of bicistronic CAR T cells that target multiple antigens expressed in neuroblastoma to overcome antigenic heterogeneity. Combining this approach with interventions that enhance T cell trafficking and prevent acquired dysfunction in the TME may lead to a long-awaited breakthrough in the clinical implementation of CAR T cells for the treatment of solid tumors.
Radical or Expectant Therapy of Acute Cholecystitis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE MEDICAL AND SURGICAL HISTORY OF THE WAR OF THE REBELLION.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nutrition and Food Chemistry.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An esterase-responsive ibuprofen nano-micelle pre-modified embryo derived nucleus pulposus progenitor cells promote the regeneration of intervertebral disc degeneration
Authors: Kai-shun Xia, Dong-dong Li, Cheng-gui Wang, Li-wei Ying, Jing-kai Wang, Biao Yang, Jia-wei Shu, Xian-peng Huang, Yu-ang Zhang, Chao Yu, Xiao-peng Zhou, Fang-cai Li, Nigel K.H. Slater, Jian-bin Tang, Qi-xin Chen, Cheng-zhen Liang
Journal: Bioactive Materials (2022)

Stem cell-based transplantation is a promising therapeutic approach for intervertebral disc degeneration (IDD). Current limitations of stem cells include with their insufficient cell source, poor proliferation capacity, low nucleus pulposus (NP)-specific differentiation potential, and inability to avoid pyroptosis caused by the acidic IDD microenvironment after transplantation. To address these challenges, embryo-derived long-term expandable nucleus pulposus progenitor cells (NPPCs) and esterase-responsive ibuprofen nano-micelles (PEG-PIB) were prepared for synergistic transplantation. In this study, we propose a biomaterial pre-modification cell strategy; the PEG-PIB were endocytosed to pre-modify the NPPCs with adaptability in harsh IDD microenvironment through inhibiting pyroptosis. The results indicated that the PEG-PIB pre-modified NPPCs exhibited inhibition of pyroptosis in vitro; their further synergistic transplantation yielded effective functional recovery, histological regeneration, and inhibition of pyroptosis during IDD regeneration. Herein, we offer a novel biomaterial pre-modification cell strategy for synergistic transplantation with promising therapeutic effects in IDD regeneration.
The Principles of Hygiene. A Practical Manual for Students, Physicians, and Health-Officers.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetic Testing for Susceptibility to Adult-Onset Cancer
Authors: Gail Geller
Journal: JAMA (1997)

<h3>Objective.</h3> —To provide guidance on informed consent to clinicians offering cancer susceptibility testing. <h3>Participants.</h3> —The Task Force on Informed Consent is part of the Cancer Genetics Studies Consortium (CGSC), whose members were recipients of National Institutes of Health grants to assess the implications of cancer susceptibility testing. The 10 task force members represent a range of relevant backgrounds, including various medical specialties, social science, genetic counseling, and consumer advocacy. <h3>Evidence.</h3> —The CGSC held 3 public meetings from 1994 to 1996. At its first meeting, the task force jointly established a list of topics. The cochairs (G.G. and J.R.B) then developed an outline and assigned each topic to an appropriate writer and reviewer. Writers summarized the literature on their topics and drafted recommendations, which were then revised by the reviewers. The cochairs compiled and edited the entire manuscript. All members were involved in writing this report. <h3>Consensus Process.</h3> —The first draft was distributed to task force members, after which a meeting was held to discuss its content and organization. Consensus was reached by voting. A subsequent draft was presented to the entire CGSC at its third meeting, and comments were incorporated. <h3>Conclusions.</h3> —The task force recommends that informed consent for cancer susceptibility testing be an ongoing process of education and counseling in which (1) providers elicit participant, family, and community values and disclose their own, (2) decision making is shared, (3) the style of information disclosure is individualized, and (4) specific content areas are discussed.
GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting and -activating properties of human salivary histatin 1
Authors: Dandan Ma, Wei Sun, Cuicui Fu, Kamran Nazmi, Enno C I Veerman, Richard T Jaspers, Jan G M Bolscher, Floris J Bikker, Gang Wu
Journal: International Journal of Oral Science (2022)

Abstract Human salivary histatin 1 (Hst1) exhibits a series of cell-activating properties, such as promoting cell spreading, migration, and metabolic activity. We recently have shown that fluorescently labeled Hst1 (F-Hst1) targets and activates mitochondria, presenting an important molecular mechanism. However, its regulating signaling pathways remain to be elucidated. We investigated the influence of specific inhibitors of G protein-coupled receptors (GPCR), endocytosis pathways, extracellular signal-regulated kinases 1/2 (ERK1/2) signaling, p38 signaling, mitochondrial respiration and Na+/K+-ATPase activity on the uptake, mitochondria-targeting and -activating properties of F-Hst1. We performed a siRNA knockdown (KD) to assess the effect of Sigma-2 receptor (S2R) /Transmembrane Protein 97 (TMEM97)—a recently identified target protein of Hst1. We also adopted live cell imaging to monitor the whole intracellular trafficking process of F-Hst1. Our results showed that the inhibition of cellular respiration hindered the internalization of F-Hst1. The inhibitors of GPCR, ERK1/2, phagocytosis, and clathrin-mediated endocytosis (CME) as well as siRNA KD of S2R/TMEM97 significantly reduced the uptake, which was accompanied by the nullification of the promoting effect of F-Hst1 on cell metabolic activity. Only the inhibitor of CME and KD of S2R/TMEM97 significantly compromised the mitochondria-targeting of Hst1. We further showed the intracellular trafficking and targeting process of F-Hst1, in which early endosome plays an important role. Overall, phagocytosis, CME, GPCR, ERK signaling, and S2R/TMEM97 are involved in the internalization of Hst1, while only CME and S2R/TMEM97 are critical for its subcellular targeting. The inhibition of either internalization or mitochondria-targeting of Hst1 could significantly compromise its mitochondria-activating property.
ESMO Expert Consensus Statements on Cancer Survivorship: promoting high-quality survivorship care and research in Europe
Authors: I. Vaz-Luis, M. Masiero, G. Cavaletti, A. Cervantes, R.T. Chlebowski, G. Curigliano, E. Felip, A.R. Ferreira, P.A. Ganz, J. Hegarty, J. Jeon, C. Johansen, F. Joly, K. Jordan, B. Koczwara, P. Lagergren, M. Lambertini, D. Lenihan, H. Linardou, C. Loprinzi, A.H. Partridge, S. Rauh, K. Steindorf, W. van der Graaf, L. van de Poll-Franse, G. Pentheroudakis, S. Peters, G. Pravettoni
Journal: Annals of Oncology (2022)
Associations of serum sclerostin levels with body composition, pulmonary function, and exacerbations in COPD patients
Authors: C.A. Amado, M. García-Unzueta, J. Agüero, P. Martín-Audera, P. Fueyo, B.A. Lavín, A.R. Guerra, P. Muñoz, S. Tello, A. Berja, C. Casanova
Journal: Pulmonology (2022)

In COPD, the bronchial epithelium shows a pathologically activated Wnt pathway. Sclerostin (SOST) is a secreted glycoprotein that is associated with bone metabolism and blocks the Wnt pathway. We hypothesized that low sclerostin levels might be associated with lung function and COPD exacerbations in patients.
A national advanced training program for laparoscopic radical gastrectomy has a positive impact on surgical trainees: A before and after study (ATP-LRG-1)
Authors: Zu-Kai Wang, Jian-Xian Lin, Jiao-Bao Huang, Jun Lu, Ze-Ning Huang, Jian-Wei Xie, Jia-Bin Wang, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ju-Li Lin, Hua-Long Zheng, Ping Li, Chao-Hui Zheng, Chang-Ming Huang
Journal: International Journal of Surgery (2022)
Effectiveness of a remote simulation training in mechanical ventilation among trainees
Authors: M. Ippolito, B. Simone, S. Safadi, E. Spinuzza, T. Catania, G. Ingoglia, M. Milazzo, S.M. Raineri, A. Giarratano, C. Gregoretti, A. Cortegiani
Journal: Pulmonology (2022)
First two cases of Monkeypox virus infection in travellers returned from UAE to India, July 2022
Authors: Pragya D Yadav, Aravind Reghukumar, Rima R Sahay, Sudeep K, Anita M Shete, Aruna Raman, Pramod Vk, Priya Abraham, Reshma Benson, Sarin Sm, Sreelekshmy Mohandas, Deepak Y Patil, Abhinendra Kumar, Nivedita Gupta, Anuja Elizabeth George, Neetu Vijay, Anuja U, Manjusree Suresh, Ramiz Raja A, Gajanan N Sapkal, Manasi Ravindranath, Sreenath Sreenivasan, Preethi James, Shaj Mk
Journal: Journal of Infection (2022)
Safety and efficacy of prophylactic levetiracetam for prevention of epileptic seizures in the acute phase of intracerebral haemorrhage (PEACH): a randomised, double-blind, placebo-controlled, phase 3 trial
Authors: Laure Peter-Derex, Frédéric Philippeau, Pierre Garnier, Nathalie André-Obadia, Sébastien Boulogne, Hélène Catenoix, Philippe Convers, Laure Mazzola, Michel Gouttard, Maud Esteban, Julia Fontaine, Laura Mechtouff, Elodie Ong, Tae-Hee Cho, Norbert Nighoghossian, Nathalie Perreton, Anne Termoz, Julie Haesebaert, Anne-Marie Schott, Muriel Rabilloud, Christine Pivot, Carole Dhelens, Andrea Filip, Yves Berthezène, Sylvain Rheims, Florent Boutitie, Laurent Derex
Journal: The Lancet Neurology (2022)
Incremental prognostic value of acute serum biomarkers for functional outcome after traumatic brain injury (CENTER-TBI): an observational cohort study
Authors: Isabel R A Retel Helmrich, Endre Czeiter, Krisztina Amrein, András Büki, Hester F Lingsma, David K Menon, Stefania Mondello, Ewout W Steyerberg, Nicole von Steinbüchel, Kevin K W Wang, Lindsay Wilson, Haiyan Xu, Zhihui Yang, David van Klaveren, Andrew I R Maas
Journal: The Lancet Neurology (2022)
A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs
Authors: Bram Bogaert, Félix Sauvage, Roberta Guagliardo, Cristina Muntean, Van Phuc Nguyen, Eline Pottie, Mike Wels, An-Katrien Minnaert, Riet De Rycke, Qiangbing Yang, Dan Peer, Niek Sanders, Katrien Remaut, Yannis M. Paulus, Christophe Stove, Stefaan C. De Smedt, Koen Raemdonck
Journal: Journal of Controlled Release (2022)
Prognostic value of day-of-injury plasma GFAP and UCH-L1 concentrations for predicting functional recovery after traumatic brain injury in patients from the US TRACK-TBI cohort: an observational cohort study
Authors: Frederick K Korley, Sonia Jain, Xiaoying Sun, Ava M Puccio, John K Yue, Raquel C Gardner, Kevin K W Wang, David O Okonkwo, Esther L Yuh, Pratik Mukherjee, Lindsay D Nelson, Sabrina R Taylor, Amy J Markowitz, Ramon Diaz-Arrastia, Geoffrey T Manley
Journal: The Lancet Neurology (2022)

The prognostic value of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) as day-of-injury predictors of functional outcome after traumatic brain injury is not well understood. GFAP is a protein found in glial cells and UCH-L1 is found in neurons, and these biomarkers have been cleared to aid in decision making regarding whether brain CT should be performed after traumatic brain injury. We aimed to quantify their prognostic accuracy and investigate whether these biomarkers contribute novel prognostic information to existing clinical models.
Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells
Authors: Doumet Georges Helou, Christine Quach, Marshall Fung, Jacob D. Painter, Benjamin P. Hurrell, Yong-Hwee Eddie Loh, Emily Howard, Pedram Shafiei-Jahani, Pejman Soroosh, Arlene H. Sharpe, Omid Akbari
Journal: Journal of Allergy and Clinical Immunology (2022)
Desmoplastic melanoma treated with wide local excision or Mohs micrographic surgery: Rates of positive margins, local recurrence, and repeat surgeries
Authors: Nina A. Ran, Shannon T. Nugent, Surya A. Veerabagu, Emily Y. Chu, Mitul B. Modi, Joseph F. Sobanko, Jeremy R. Etzkorn, Thuzar M. Shin, Harold W. Higgins, Cerrene N. Giordano, Stacy L. McMurray, Joanna L. Walker, Carolyn M. Stull, Christopher J. Miller
Journal: Journal of the American Academy of Dermatology (2022)
Effects of DDT on Amyloid Precursor Protein Levels and Amyloid Beta Pathology: Mechanistic Links to Alzheimer’s Disease Risk
Authors: Aseel Eid, Isha Mhatre-Winters, Ferass M. Sammoura, Melissa K. Edler, Richard von Stein, Muhammad M. Hossain, Yoonhee Han, Miriam Lisci, Kristina Carney, Mary Konsolaki, Ronald P. Hart, Joan W. Bennett, Jason R. Richardson
Journal: Environmental Health Perspectives (2022)

Background: The interaction of aging-related, genetic, and environmental factors is thought to contribute to the etiology of late-onset, sporadic Alzheimer’s disease (AD). We previously reported that serum levels of p,p′-dichlorodiphenyldichloroethylene (DDE), a long-lasting metabolite of the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT), were significantly elevated in patients with AD and associated with the risk of AD diagnosis. However, the mechanism by which DDT may contribute to AD pathogenesis is unknown. Objectives: This study sought to assess effects of DDT exposure on the amyloid pathway in multiple in vitro and in&nbsp;vivo models. Methods: Cultured cells (SH-SY5Y and primary neurons), transgenic flies overexpressing amyloid beta (Aβ), and C57BL/6J and 3xTG-AD mice were treated with DDT to assess impacts on the amyloid pathway. Real time quantitative polymerase chain reaction, multiplex assay, western immunoblotting and immunohistochemical methods were used to assess the effects of DDT on amyloid precursor protein (APP) and other contributors to amyloid processing and deposition. Results: Exposure to DDT revealed significantly higher APP mRNA and protein levels in immortalized and primary neurons, as well as in wild-type and AD-models. This was accompanied by higher levels of secreted Aβ in SH-SY5Y cells, an effect abolished by the sodium channel antagonist tetrodotoxin. Transgenic flies and 3xTG-AD mice had more Aβ pathology following DDT exposure. Furthermore, loss of the synaptic markers synaptophysin and PSD95 were observed in the cortex of the brains of 3xTG-AD mice. Discussion: Sporadic Alzheimer’s disease risk involves contributions from genetic and environmental factors. Here, we used multiple model systems, including primary neurons, transgenic flies, and mice to demonstrate the effects of DDT on APP and its pathological product Aβ. These data, combined with our previous epidemiological findings, provide a mechanistic framework by which DDT exposure may contribute to increased risk of AD by impacting the amyloid pathway. https://doi.org/10.1289/EHP10576
Regenerative medicine: postnatal approaches
Authors: Paul Kwong Hang Tam, Kenneth Kak Yuen Wong, Anthony Atala, Giovanni Giuseppe Giobbe, Claire Booth, Peter J Gruber, Mimmi Monone, Shahin Rafii, Thomas A Rando, Joseph Vacanti, Carly D Comer, Nicola Elvassore, Tracy Grikscheit, Paolo de Coppi
Journal: The Lancet Child & Adolescent Health (2022)