tbuckley/cabot-search huggingface dataset:
The Jamaica ginger paralysis
Authors: J. P. Morgan
Journal: JAMA (1982)

AN EPIDEMIC of partial paralysis ultimately affecting 50,000 Americans became manifest in February 1930.<sup>1</sup>Although this initial and most important phase of the epidemic ended by July 1930, a new group of people were poisoned in January 1931 under circumstances as bizarre as those a year earlier.<sup>2</sup>I plan to review briefly the 50-year-old event, and the marking of that anniversary may be reason enough to command attention. However, I have two other goals. The toxin that caused the illness will not go away, and the most recent epidemic occurred in 1978. Additionally, in my first report of the "Jake Walk Blues,"3 I was unable to describe or identify the real culprits who provoked the massive poisoning. In the past few months, I was led to, and have now read, some 1,200 pages detailing the investigation of the adulterated Jamaica ginger extract written by the field staff of
Incorporated Environment
Journal: JAMA (1970)

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The Etiology of Syphilis
Journal: JAMA (2014)

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Lipid Research Clinics Program-Reply
Authors: Basil M. Rifkind
Journal: JAMA (1984)

<h3>In Reply.—</h3> Clearly, the LRC-CPPT did not measure all factors that may be related to subsequent occurrence of CHD end points. No baseline assessment of coronary-prone behavior was done. While considerable data on family history and the presence of CHD manifestations were collected, we did not attempt to determine which men had monogenic FH or to quantify the degree of atherosclerosis in each man's coronary arteries. Even if every conceivable measurement of every known risk factor had been performed—a very impractical proposition—one would still be limited by current levels of understanding and technology and could not guarantee equality of treatment groups with respect to as yet undiscovered risk factors.<i>The practical solution to this conundrum, which is used in nearly all large clinical trials, is randomization</i>. The random assignment of more than 3,800 men to the two LRC-CPPT treatment groups, which resulted in their near equality with respect to 83
HOUSE OF DELEGATES ADOPTS POLICIES ON SICKNESS CARE
Journal: JAMA (1935)

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Pathogenesis of Human Urinary Bladder Cancer
Authors: George T. Bryan
Journal: Environmental Health Perspectives (1983)

The pathogenesis of bladder cancer is being analyzed at several levels of biological organization, i.e., population groups, individual whole animal, tissue, cell, molecule, etc. Each of these levels provides opportunities for mechanistic studies. Yet the integration of these several levels into a cohesive fabric is incomplete. From a clinical point of view, the following seem of importance to human bladder cancer pathogenesis. The initiation, promotion, and progression of bladder cancer involves several factors acting concurrently or sequentially. These factors appear to be naturally occurring or synthetically created chemicals present in the external environment. Human exposures to these agents may begin in utero, and varying, dynamic qualitative and quantitative exposure patterns continue through developmental and adult life. Apparent latent periods of development of clinical bladder cancer may be as short as one, or as long as 50 years or more. Individuals may exhibit differential susceptibility to vesical carcinogens, perhaps through phenotypic differences in quantitative biotransformation routes. Differences in bladder epithelial cell susceptibilities probably also occur, as well as varying local tissue and generalized resistance to neoplasia formation. Older individuals do not appear to be more resistant to bladder carcinogenesis. A number of animal model systems have been developed for the study of the in vivo, cellular, and molecular pathogenesis of bladder cancer. These models replicate many of the known salient features of human bladder cancer. Through use of appropriate whole animal models in conjunction with investigations of human and animal bladder cells and tissues in culture, controlled mechanistic and quantitative studies of bladder cancer pathogenesis should rapidly develop.
Inhibition of Platelet Glycoprotein IIb/IIIa with Eptifibatide in Patients with Acute Coronary Syndromes
Authors: The PURSUIT Trial Investigators
Journal: New England Journal of Medicine (1998)

Aggregation of platelets is the pathophysiologic basis of the acute coronary syndromes. Eptifibatide, a synthetic cyclic heptapeptide, is a selective high-affinity inhibitor of the platelet glycoprotein IIb/IIIa receptor, which is involved in platelet aggregation. We tested the hypothesis that inhibition of platelet aggregation with eptifibatide would have an incremental benefit beyond that of heparin and aspirin in reducing the frequency of adverse outcomes in patients with acute coronary syndromes who did not have persistent ST-segment elevation.
THE OUTDOOR TREATMENT OF TUBERCULOSIS.*
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The oath of the healer
Authors: L. Weinstein
Journal: JAMA (1991)

<h3>To the Editor. —</h3> The essence of my plan is to allow those practicing physicians and surgeons who wish to do so to deduct from their personal federal income tax returns their usual (or even discounted) charges for care provided to the Medicaid and uninsured population. Federal and state Medicaid outlays in 1989 exceeded $71 billion (<i>New York Times</i>. November 4, 1990:1, 14). If physician-allocated payments are 20% of that total, then approximately $14 billion is being spent through Medicaid. There are 570 000 practicing physicians and surgeons in the United States; if each who elected to participate provided $100 000 in "free care" and their federal deductions were discounted to 75% of charges, then $75 000 per physician per year might be deducted. Assuming the top marginal tax bracket for each one, this would result in approximately $23 000 in reduced taxes. Multiplied nationwide, a $13 billion reduction in
Changes in prostate cancer detection rate of fusion versus systematic biopsy over time: A single center experience.
Authors: Brian P. Calio, Abhinav Sidana, Dordaneh Sugano, Amit L Jain, Mahir Maruf, Maria J Merino, Baris Turkbey, Peter L. Choyke, Bradford J. Wood, Peter A. Pinto
Journal: Journal of Clinical Oncology (2017)
Unquiet rest.
Journal: BMJ (1972)

Unquiet RestAs man's numbers have grown, so his peace and quiet have diminished.Though wealthier, he finds he has destroyed wildlife, scenic beauty, and solitude.The jet aircraft brought convenience to a privileged few but many people who have to live near airports prefer the older and quieter turboprops.Heavier lorries and more powerful planes can find support in economic statistics but it is less easy to quantify the damage they do to the quality of life.A recent study, however, has done this for some ill-effects of aircraft noise.
Correction
Journal: Circulation (1967)

In the article on "Pressure-Flow Studies in Man During the Valsalva Maneuver with Observations on the Mechanical Properties of the Ascending Aorta" by Joseph C. Greenfield, Jr., Ronnie L. Cox, Rafael R. Hernandez, Corinna Thomas and Fred W. Schoonmaker (April CIRCULATION 35: 653-661, 1967), formula #1 on page 654 should read: [See Equation in PDF File]
Reproductive mortality.
Authors: V Beral
Journal: BMJ (1979)

The transfer from traditional to modern methods of contraception in recent decades has been accompanied by a transfer of deaths from complications of pregnancy to deaths from complications of the modern contraceptive methods. In 1975, for example, it is estimated that there were more deaths at ages 25-44 years in England and Wales from adverse effects of oral contraceptive use than from all complications of pregnancy, delivery, and the puerperium combined. Thus maternal mortality is no longer an adequate indicator of the deaths associated with reproduction in the community. An alternative measure, the reproductive mortality rate should be used, which includes deaths from complications of contraceptive use as well as those from complications of pregnancy or abortion. The reproductive mortality rate in England and Wales seems to have declined continuously since 1950 for women aged 25-34. But after 1960 it increased for women aged 35-44, because of the higher mortality associated with oral contraceptive use in this age group.
Oncology Research Program
Authors: Ajay Gopal, Paul Martin
Journal: Journal of the National Comprehensive Cancer Network (2016)

The goal of the Highlights of the NCCN Oncology Research Program (ORP) is to provide readers with more information on the ORP, including studies currently accruing patients.For more information on specific trials, including patient selection criteria, please use the contact information listed with each study.For more information on the NCCN ORP, including a complete detailing of the clinical studies currently underway at NCCN Member Institutions, please access the NCCN ORP pages at NCCN.org/clinical_trials/ clinicians.asp.
Miscellanea Medica
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: L. F Mckay, M A Eastwood, G. Brydon
Journal: Gut (1985)

Dryland wheat (<i>Triticum aestivum</i> L.) is the principal crop grown on 3.35 million ha (8.28 million ac) of the semiarid Inland Pacific Northwest of the United States. In areas with less than 300 mm (12 in) of annual precipitation, challenges for wheat production are similar to those found in the Mediterranean region and Australia. Successful crop production depends on adequate precipitation capture and storage and weed control, which prove problematic under no-tillage (NT), the most effective soil conservation practice. Sweep-tillage (ST) is proposed as an equally effective conservation system, with local conventional wisdom saying that it produces higher yields than NT systems. A study established in 2006 and concluded in 2018 evaluated the performance of NT and ST winter wheat–summer fallow production systems. The null hypothesis for this research assumed no statistically significant differences in any of the soil and plant characteristics measured between NT and ST treatments. Sixteen 0.04 ha (0.10 ac) plots were established in a randomized complete block design, with two rotation entry points for a total of four treatment plots per year replicated in four blocks. Data were analyzed using a generalized linear mixed model. The NT system produced significantly higher crop yields and higher precipitation use efficiencies than the ST system (NT 3.38 ± 0.33, ST 2.66 ± 0.27 Mg ha<sup>–1</sup> [NT 50 ± 5, ST 40 ± 4 bu ac<sup>–1</sup>]). Infiltration rates were higher and soil temperatures were lower in the NT system. The higher yields and lower soil temperatures in the NT system were unexpected and contrary to previous research conducted in this region.
Water
Authors: Michael Wynn
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Digest of Comments on the Pharmacopeia of the United States of America (Eighth Decennial Revision) and on the National Formulary (Third Edition).
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Live influenza virus vaccines.
Journal: BMJ (1974)

specific indicator of epithelial cell damage but may enhance the diarrhoea, which may be particularly important in children, who tolerate lactase deficiency badly.Thirdly, the effects of a virus on intestinal function can be measured.Absorption of xylose, fat, and lactose may be decreased during the acute phase of the disease and may be prolonged well into the con- valescent stage.Occasionally standard absorption tests are depressed in the absence of clinical illness.4Xylose absorption tests could theoretically be abnormal as a result of gastric stasis, which may be profound, but absorption has been shown to be impaired even after intraduodenal administration of the sugar.' 9 Finally, faecal leucocyte excretion is not increased in viral enteritis, which is a simple way of distinguishing it from diarrhoea due to bacterial infection or ulcerative colitis.4 22 Possibly jejunal biopsy and simple absorption tests are better markers of the presence of disease than are clinical symptoms.However, a comparison of these methods with screening for faecal virus particles will be interesting.For the moment, the general practitioner can be reassured that a disease which he regularly diagnoses actually exists.
The 1935 Year Book of Neurology, Psychiatry and Endocrinology. Edited by<i>Hans H. Reese, M. D., Harry A. Paskind, M. D., and Elmer L. Sevringhaus, M. D.</i>(Chicago: The Year Book Publishers, 1936.)
Authors: C. B. F.
Journal: American Journal of Psychiatry (1936)
Cholesterol and coronary heart disease: a perspective
Authors: S. H. Rahimtoola
Journal: JAMA (1985)

In this issue ofTHE JOURNALis the statement of the National Institutes of Health Consensus Development Conference on lowering blood cholesterol<sup>1</sup>; their recommendations are reasonable and can be supported. However, it is important at this point to review certain related issues. There is no doubt that elevated blood cholesterol levels and other "high-risk" factors, such as cigarette smoking, high blood pressure, obesity, physical inactivity, male sex, stressful lifestyle, and strong family history, are associated with an increased risk of development of coronary artery disease. However, even if all the recognized risk factors were eliminated except for the male sex, coronary atherosclerosis and death from coronary artery disease will<i>not</i>disappear. Therefore, it needs to be recognized that we do<i>not</i>yet know the cause(s) of coronary atherosclerosis<sup>2</sup>and there is a need for continued research to discover the cause(s) and specific treatment of coronary atherosclerosis. The recent interest,
Smoking and coronary heart disease in women
Authors: C. H. Hennekens
Journal: JAMA (1985)

The average lifespan of Americans is currently at a record high, having increased 3.8 years overall from 1970 to 1983.<sup>1</sup>The life expectancy of women, however, is still markedly higher than that of men. At 1983 US death rates, women can expect to live 78.3 years, while the corresponding figure for men is 71 years. The favorable survival experience of women has been due, in part, to their lower rates of lung cancer, the chief cause of cancer deaths, and of coronary heart disease (CHD), the leading cause of all US deaths. In contrast to this encouraging news is the fact that, at present, cigarette smoking is known to be responsible for 85% to 90% of the approximately 120,000 annual lung cancer deaths expected this year in the United States (plus several tens of thousands of other cancer deaths),<sup>2</sup>as well as perhaps 20% or more of all