tbuckley/cabot-search huggingface dataset:
AB0020 The Role of Epigenetics in Determining the Clinical Response To Methotrexate for the Treatment of Rheumatoid Arthritis
Authors: S. Cregan, K. Creevey, T. McGarry, C. Orr, D.J. Veale, U. Fearon, A.G. Wilson
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Rheumatoid Arthritis (RA) is a chronic inflammatory autoimmune disease, affecting around 1% of the population, causing significant ill health, disability and increased mortality. The precise etiology of RA is not known, but both genetic and environmental influences play a role. Methotrexate (MTX) is the most commonly used disease modifying anti-rheumatic drug in the management of RA, however its mechanism of action has not been extensively studied. <h3>Objectives</h3> The aim of this study is to determine the functional effect of MTX in the RA joint. <h3>Methods</h3> Primary RA synovial fibroblasts (RASFC) were isolated from synovial biopsies obtained from patients undergoing arthroscopic examination. RASFC were cultured in the presence or absence of MTX (10-100uM) and cell migration, invasion, cytoskeletal rearrangement, viability, proliferation and pro-inflammatory cytokine expression were assessed by wound repair assays, transwell matrigel™ invasion chambers, F-actin immunofluorescent staining, MTT/ Crystal violet cell growth assay and ELISA respectively. In parallel, CD14+monocytes were isolated from peripheral blood mononuclear cells from RA patients both pre- and 12 weeks post-MTX therapy (n=5) and global methylation was assessed by a 5-methylcytosine DNA ELISA kit. <h3>Results</h3> MTX (10-100uM) inhibited RASFC repopulation of the wound margins in comparison to vehicle control where migration across the wound was clearly evident (p&lt;0.05). In parallel, MTX significantly decreased RASFC invasion (p&lt;0.05) and altered cytoskeletal dynamics through inhibition of lamellopodia and filopodia formation, which are indicative of cell movement. Importantly, we determined that the effect of MTX on RASFC migration and invasion were independent of both cell viability and proliferation. Finally preliminary results demonstrated altered DNA methylation in CD14+ monocytes from RA patients at 3 months post MTX treatment. <h3>Conclusions</h3> MTX inhibits RASFC migration, invasion and cytoskeletal re-arrangement, mechanisms which are critically involved in the pathogenesis of RA. Further preliminary data suggests that the effect of MTX on pro-inflammatory mechanisms in RA, maybe be mediated through alterations in epigenome. <h3>Disclosure of Interest</h3> S. Cregan: None declared, K. Creevey: None declared, T. McGarry: None declared, C. Orr: None declared, D. Veale Grant/research support from: Abbvie, MSD, Pfizer, Roche, Consultant for: Pfizer, Roche, Speakers bureau: Abbott, MSD, Pfizer, Roche, U. Fearon: None declared, A. Wilson: None declared
Current Diagnosis
Authors: Harold Nachimson
Journal: JAMA (1985)

Good books, like good families, seem to produce good progeny, and so it is with this youngest in a long line of excellent works. Previous editions of the monumental and massive<i>Current Diagnosis</i>were in the expert and diligent care of Howard Conn and Rex Conn. Rex Conn, after the unfortunate death of Howard Conn, is doing a perfectly admirable job of carrying on as principal editor. A special mention is made of Howard Conn's contribution, and I think this book serves well as a fitting monument to the foundation he laid in the previous six editions. The book is a classic, as its predecessors have been, with 1,364 pages full of vital, up-to-date, and knife's edge material in medical diagnosis. The limitation of the book is deliberate in that the intention of the editor and contributors is primarily to have a diagnostic reference text enabling specialists and generalists alike
Letter: Hyperthyroidism after use of contrast medium.
Authors: A Frankland, Raouf Abdel-Maguid
Journal: BMJ (1975)

Adrenaline in the treatment of anaphylaxis SIR,-We would agree with Dr L M McEwen's observations (13 September.p 649) that prophylactic steroid cover is un- likely to be of any help in the treatment of anaphylaxis, but we cannot possibly agree with his statement that "when faced with profound anaphylactic collapse most doctors give adrenaline intravenously, using 0 5 ml of 1/1000 solution, diluted if possible, given slowly."We consider the risks of intravenous adrenaline are so great that no general prac- titioner should ever give it in this way.Besides the very severe subjective symptoms that will arise, the more serious effects of cerebral haemorrhage and cardiac arrhythmias preclude its use intravenously except in exceptional circumstances, when it must be adequately diluted.'
L'intoxication par les somniferes (intoxication barbiturique)
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dermatologic Therapy
Authors: John Godwin Downing
Journal: New England Journal of Medicine (1950)

PROGRESS in the therapy of cutaneous diseases during the last few years has been tremendous. Dermatologists observing the reactions on the skin have been able to keep other physicians informed regarding the useful as well as the undesirable reactions of new drugs. They have demonstrated that sensitization to these agents affects not only the skin but also important organs of the body. This subject is of vital significance. Few physicians realize the disability, economic loss and suffering that result from sensitization to a drug, varying from the usual two-week period of incapacitation to permanent disability, or even death. Therefore, this . . .
Reflux dyspareunia.
Authors: A J Kirk
Journal: Thorax (1986)

In a prospective study of 100 women with known gastro-oesophageal reflux 77% suffered to some extent from symptoms resulting from it during sexual intercourse (called here "reflux dyspareunia").A simple treatment plan of explanation and conservative measures was used, and this produced improvement in 61 of the 77 patients.
Mechanism of cell and tissue damage produced by immune reactions; IInd International symposium on immunopathology, Brook Lodge (Michigan, USA) 1961.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LITERATURE REFERENCES.
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
StatBite: Global Survey: Women Living With Metastatic Breast Cancer and Clinical Trial Participation
Journal: JNCI Journal of the National Cancer Institute (2009)

As part of an effort to better assess the unmet needs of women living with metastatic breast cancer (MSC), researchers conducted a psychosocial oncology survey of 950 women among nine countries on clinical trial participation.According to the study, most women living with MSC had not participated in a clinical trial: 56% of those women reported that they were never invited to consider a trial and 30% said they had not been recommended one by their healthcare provider.In contrast, 77% of women who did participate in a clinical trial cited encouragement from their healthcare provider as a reason for participation.Findings from this BRIDGE (Bridging Gaps, Expanding Research) study were presented at the American Association for Cancer Research meeting in April."The BRIDGE survey shows that knowledge is power when it comes to clinical trials," said Lesley Fallowfield, of the Cancer Research UK Psychosocial Oncology Group, University of Sussex, in a news release."Physician influence is a primary factor driving participation, but patients can only take an active role if they are aware of all their treatment options and are encouraged to enquire about treatments available within a clinical trial."
Reply:
Authors: Richard A. Del Rio, Anthony B. Post, Mendel E. Singer
Journal: Hepatology (2007)

We thank the alert readers for pointing out an error in a citation in our recent article.1 The cost of darbepoetin alpha used in our analysis is not the average wholesale price. Although it has no bearing on our results, we apologize for any confusion created by this error. In practice, the price paid for darbepoetin alpha is far less than the average wholesale price. In a 2005 study of 46 independent dialysis facilities, the average price paid before discounts and rebates was $3.14/μg, and the average net acquisition cost was $2.59/μg, that is, 17.5% lower.2 The figure we used, $2.78/μg, is 7.5% above the average price paid after discounts and rebates. We believe this is a reasonably conservative estimate of the actual cost to facilities and is a much fairer and more relevant representation than the $5.13/μg average wholesale price. Our primary analysis and sensitivity analyses were based on darbepoetin alpha. Our inclusion of epoetin alpha was a form of sensitivity analysis, and use of its average wholesale price represented an upper bound on the cost of using hematologic growth factors. Our baseline analysis, depending on the genotype, produced an incremental cost-effectiveness ratio of $34,000 to $35,000 per quality-adjusted life year (QALY) on the basis of $2.78/μg, and our upper bound resulted in an incremental cost-effectiveness ratio of $61,000 to $64,000 per QALY on the basis of $5.13/μg. Although we believe that most facilities will be able to acquire darbepoetin alpha at a cost comparable to our baseline analysis, the beauty of sensitivity analysis is that an individual facility can, on the basis of the cost that it pays, interpolate to estimate the incremental cost-effectiveness ratio for itself. Richard A. Del Rio* , Anthony B. Post* , Mendel E. Singer* , * Division of Gastroenterology and Hepatology, University Hospitals of Cleveland, Cleveland, OH, Case School of Medicine, Case Western Reserve University, Cleveland, OH.
Kohl: A Lead-Hazardous Eye Makeup from the Third World to the First World
Authors: Carol Parry, Joseph Eaton
Journal: Environmental Health Perspectives (1991)

Kohl is a widely used traditional come.It is mainy worn arownd the eyes in Asia, Africa, and the Middle East.It may be a pervasive source of lead poisnn in thoe areas and among individuals fm those ars who have im- migrated to d d naos Sam of kohl were pIn Memcco, Mauri_ania, Gret Britain, and the United States.Some of these samples oriat from P stan, India, and Saudi Ara .Kohl is widely beled to consst of antimony, but analsis onstly r d only trace mou of anty.Nine of the twenty-tw samples tested contained less thlan Q6% lead; however, seven samples had lead lves in excess of 50%.The remainder ranged from 3.31 to 37.3%.ThIrd-world-manufactured kohls were u ed in the United States and Bitain, A.that this hazard is no longer confind to the third world.Those kobbls that contained kad were sold in violation of laws on lead in cosmetics in both of these nations.Third-word phins and health care workers appear to be unaware of possible lead uptake from unspected trad ly used items.Physicians in developed natiom with patients from Asia, the Middle East, and North Africa need to bctor in the possbility of past or present lead intake from unor- thodox sources such as kohl.
Electrical Treatment.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Choice
Authors: H.J. Van Peenen
Journal: Annals of Internal Medicine (1998)

Ad Libitum1 July 1998ChoiceH.J. Van PeenenH.J. Van PeenenPonca City, OK 74604-2513.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-1-199807010-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The authors [1] write that intheir study of converters three young menwere not infected by an accidentor casual carelessness. All three,knowing well how it would be,deliberately and with informed consent,chose to yield themselves to HIV.Can we believe the choice they made?We who pray for nothing else, but praythat we not die that way, that we evadenot only HIV, but every pain,the prostate's bone-wrack or the breast's,dementia's death in life, paralysis,even the so-called “minor” agonyof lungs too scarred to breathe?already of that doomed fraternity.... References1. Schacker T, Collier AC, Hughes J, Shea T, Corey L. Clinical and epidemiologic features of primary HIV infection. Ann Intern Med. 1995; 125:257-69. Google Scholar Author, Article, and Disclosure InformationAffiliations: Ponca City, OK 74604-2513.Corresponding Author: H.J. Van Peenen, 1414 East Hartford, Unit #9, Ponca City, OK 74604-2513. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1998Volume 129, Issue 1Page: 69KeywordsDementiaHIVLungsParalysisPlague ePublished: 15 August 2000 Issue Published: 1 July 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Archives of Physical Medicine, Chicago
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis
Authors: G. P. Chrousos
Journal: JAMA (1992)

<h3>Objective.</h3> —This article defines stress and related concepts and reviews their historical development. The notion of a stress system as the effector of the stress syndrome is suggested, and its physiologic and pathophysiologic manifestations are described. A new perspective on human disease states associated with dysregulation of the stress system is provided. <h3>Data Sources.</h3> —Published original articles from human and animal studies and selected reviews. Literature was surveyed utilizing MEDLINE and the<i>Index Medicus</i>. <h3>Study Selection.</h3> —Original articles from the basic science and human literature consisted entirely of controlled studies based on verified methodologies and, with the exception of the most recent studies, replicated by more than one laboratory. Many of the basic science and clinical studies had been conducted in our own laboratories and clinical research units. Reviews cited were written by acknowledged leaders in the fields of neurobiology, endocrinology, and behavior. <h3>Data Extraction.</h3> —Independent extraction and cross-referencing by the authors. <h3>Data Synthesis.</h3> —Stress and related concepts can be traced as far back as written science and medicine. The stress system coordinates the generalized stress response, which takes place when a stressor of any kind exceeds a threshold. The main components of the stress system are the corticotropin-releasing hormone and locus ceruleus-norepinephrine/autonomic systems and their peripheral effectors, the pituitary-adrenal axis, and the limbs of the autonomic system. Activation of the stress system leads to behavioral and peripheral changes that improve the ability of the organism to adjust homeostasis and increase its chances for survival. There has been an exponential increase in knowledge regarding the interactions among the components of the stress system and between the stress system and other brain elements involved in the regulation of emotion, cognitive function, and behavior, as well as with the axes responsible for reproduction, growth, and immunity. This new knowledge has allowed association of stress system dysfunction, characterized by sustained hyperactivity and/or hypoactivity, to various pathophysiologic states that cut across the traditional boundaries of medical disciplines. These include a range of psychiatric, endocrine, and inflammatory disorders and/or susceptibility to such disorders. <h3>Conclusions.</h3> —We hope that knowledge from apparently disparate fields of science and medicine integrated into a working theoretical framework will allow generation and testing of new hypotheses on the pathophysiology and diagnosis of, and therapy for, a variety of human illnesses reflecting systematic alterations in the principal effectors of the generalized stress response. We predict that pharmacologic agents capable of altering the central apparatus that governs the stress response will be useful in the treatment of many of these illnesses. (<i>JAMA</i>. 1992;267:1244-1252)
THE RÔLE OF STASIS IN INTESTINAL CONDITIONS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal