tbuckley/cabot-search huggingface dataset:
IN-HOSPITAL OUTCOMES OF LEFT CARDIAC SYMPATHETIC DENERVATION VS. IMPLANTABLE CARDIAC DEFIBRILLATOR IN THE MANAGEMENT OF LONG QT SYNDROME
Authors: Mohamed Raafat, Rezwan Munshi, Adnan Khan, Abdalla Raafat, Madison Lannom, Noor Subah, Omar Yacob, Tarec Elajami
Journal: Journal of the American College of Cardiology (2023)
IMPACT OF ATRIAL FIBRILLATION ON OUTCOMES IN PATIENTS HOSPITALIZED WITH NON-TRAUMATIC INTRACEREBRAL HEMORRHAGE: INSIGHTS FROM THE NATIONWIDE INPATIENT SAMPLE
Authors: Sahith Reddy Thotamgari, Akhilesh Babbili, Prabandh Reddy Buchhanolla, Harsh Patel, Samarthkumar Thakkar, Huzefa Bhopalwala, Nakeya Dewaswala, Jonathan Graff-Radford, Abhishek Deshmukh, Christopher DeSimone
Journal: Journal of the American College of Cardiology (2023)
VEIN OF MARSHALL ETHANOL INFUSION FOR ADJUNCTIVE ABLATION OF ATRIAL FIBRILLATION: SINGLE CENTER EXPERIENCE AND PROCEDURAL LEARNING CURVE
Authors: Jameson G. Wilbur, Sapan Bhuta, Piotr Horbal, Mahmoud Abdel-Rasoul, Natee Sirinvaravong, Jose Sleiman, John Lee, Grant Wallace, Emile G. Daoud, Ralph S. Augostini, Raul Weiss, Steven Jack Kalbfleisch, Salvatore Savona, Mahmoud Houmsse, John D. Hummel, Toshimasa Okabe, Muhammad Rizwan Afzal
Journal: Journal of the American College of Cardiology (2023)
THE IMPACT OF LATE PULMONIC VALVE REPLACEMENT ON VENTRICULAR ARRHYTHMIAS ASSOCIATED WITH TETRALOGY OF FALLOT (TOF) IN ADULTS
Authors: Yaser Khalid, Neethi Dasu, Kirti Dasu, Sanath Shetty, Rafail Beshai, Avuthu Sindhupavani, Christopher Chhoun
Journal: Journal of the American College of Cardiology (2023)
COMPARATIVE EFFECTIVENESS OF RADIOFREQUENCY ABLATION CATHETERS IN THE TREATMENT OF ATRIAL FIBRILLATION: A SYSTEMATIC REVIEW AND NETWORK METANALYSIS
Authors: Mahmoud Alsaiqali, Mohammed Mhanna, Harshith P. Chandrakumar, Ahmad Jallad, Adam S Budzikowski
Journal: Journal of the American College of Cardiology (2023)
PATIENT REPORTED OUTCOMES OF CATHETER ABLATION FOR ATRIAL FIBRILLATION IN PATIENTS WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION
Authors: Lorenzo Braghieri, Medhat Farwati, Walid I. Saliba, Osamah Badwan, AMR FARWATI, Rehan Karmali, Maan Fares, Venu Menon, Hiroshi Nakagawa, Oussama M. Wazni, Ayman Ali Hussein
Journal: Journal of the American College of Cardiology (2023)
PERSISTENCE OF REDUCED DOSE DOACS AND WARFARIN: A MULTINATIONAL COHORT STUDY OF INDIVIDUALS WITH INCIDENT AF
Authors: Peter Br⊘nnum Nielsen, Flemming Skj⊘th, Alexander Rieem Dun, Mathias Lilja, Iffat Rahman, Torben Bjerregaard Larsen, Mette S⊘gaard, Sigrun Halvorsen, Erik Lundström, Craig I. Coleman, Thomas Fast, Marcela Rivera
Journal: Journal of the American College of Cardiology (2023)
ASSOCIATION BETWEEN MINERALOCORTICOID RECEPTOR ANTAGONISTS AND ATRIAL FIBRILLATION: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Authors: Thalys Sampaio Rodrigues, Levindo Jose Garcia Quarto, Savio Nogueira, Anoop Ninan Koshy, Louise Burrell, H.M. Omar Farouque, Han S. Lim
Journal: Journal of the American College of Cardiology (2023)
IMPACT OF DEPRESSION ON IN HOSPITAL OUTCOMES IN PATIENTS ADMITTED FOR SUPRA VENTRICULAR TACHYCARDIA.
Authors: Abdulkareem Opeoluwa Lukan, Rukayat Otulana, Omofolarin Babayale, RICHARD ORJI, Habib Olatunji Alagbo, Benjamin Eromosele, Nelson Okoh, Tagbo Nduka, Akinkunmi Odutola
Journal: Journal of the American College of Cardiology (2023)
ADVERSE EVENTS IN TOTAL ARTIFICIAL HEART FOR END-STAGE HEART FAILURE: INSIGHT FROM THE FOOD AND DRUG ADMINISTRATION MANUFACTURER AND USER FACILITY DEVICE EXPERIENCE (MAUDE)
Authors: Min Choon Tan, Yong Hao Yeo, Jian Liang Tan, Hee Kong Fong, Bryan E-Xin Tan, Kwan S. Lee, Justin Zon-Ern Lee
Journal: Journal of the American College of Cardiology (2023)
IMPACT OF SHOCK-REDUCTION IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR PROGRAMMING ON ICD SHOCKS AND MORTALITY: REAL-WORLD INSIGHTS FROM THE CERTITUDE REGISTRY
Authors: Sebastian Beyer, Camden Harrell, Steven Mullane, James Edmund Ip, George Thomas, Christopher F. Liu, Steven M. Markowitz, Bruce B. Lerman, Jim W. Cheung
Journal: Journal of the American College of Cardiology (2023)
FULMINANT MYOCARDITIS IN PATIENTS SUPPORTED WITH EXTRACORPOREAL MEMBRANE OXYGENATION: A SYSTEMATIC REVIEW AND META-ANALYSIS OF OUTCOMES AND PROGNOSTIC FACTORS
Authors: Sameh Samir Elawady, Yomna E. Dean, Ahson Afzal, Naila Iqbal, Muluken Zeleke Megiso, Sriharsha Koduru, Mohamed Doma, Adham Galal, Mahmoud Hossameldin Elbahaey, Ahmed Magdi Youssef Ali, Dina Ismail, Basant Katamesh, Helmy Badr, Yasser Etman, Hani Aiash
Journal: Journal of the American College of Cardiology (2023)
GENDER DISPARITIES IN THE OUTCOME OF CARDIOGENIC SHOCK. A SYSTEMATIC REVIEW AND META-ANALYSIS.
Authors: Mostafa Reda Mostafa, Mohamed Eid, Waiel Abusnina, Mohamed Abuelazm, Abdul Rhman Hassan, Basant Katamesh, Abdelrahman Mahmoud, Ahmad Al-Abdouh, Sarath Lal Mannumbeth Renjithlal, Omar Tayseer Al Ali, Ahmed Salah Ahmed Aboeata
Journal: Journal of the American College of Cardiology (2023)
THE EFFECT OF MAVACAMTEN TREATMENT FOR SYMPTOMATIC, OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY IN PATIENTS WITH OR WITHOUT HYPERTENSION: ANALYSIS OF THE EXPLORER-HCM TRIAL
Authors: Andrew Wang, John A. Spertus, Daniel M. Wojdyla, Theodore P. Abraham, Ester Kim Nilles, Anjali Tiku Owens, Sara Saberi, Sharon Cresci, Amy Sehnert, Neal K. Lakdawala
Journal: Journal of the American College of Cardiology (2023)
REPERFUSION WITH 24 C COOLING IN A PORCINE MODEL OF EXTRACORPOREAL CARDIOPULMONARY RESUSCITATION
Authors: Marinos Kosmopoulos, Alexandra Marquez, Jason Alan Bartos, Alejandra Gutierrez Bernal, Adamantios Tsangaris, Tomaz Goslar, Rajat Kalra, Tamas Alexy, Andrea M. Elliott, Marie Steiner, Davis Seelig, Demetris Yannopoulos
Journal: Journal of the American College of Cardiology (2023)
ASSOCIATION OF NEIGHBORHOOD-LEVEL MATERIAL DEPRIVATION WITH ADVERSE OUTCOMES AND PROCESSES OF CARE AMONG PATIENTS WITH HEART FAILURE IN A SINGLE-PAYER HEALTHCARE SYSTEM: A POPULATION-BASED COHORT STUDY
Authors: Andrew Dorovenis, David Bobrowski, Husam Mohamed Abdel-Qadir, Candace D. McNaughton, Rea Alonzo, Jiming Fang, Peter Austin, Jacob A. Udell, Cynthia Jackevicius, David Andrew Alter, Rajan Sacha Bhatia, Clare Atzema, Andrew C.T. Ha, Sharon Johnston, Irfan Dhalla, Moira Kapral, Harlan M. Krumholz, Harindra Wijeysundera, Dennis T. Ko, Karen Tu, Heather Joan Ross, Michael Schull, Douglas Lee
Journal: Journal of the American College of Cardiology (2023)
BRIDGING THE GAP: EARLY PRIMARY CARE FOLLOW-UP IS NOT ASSOCIATED WITH REDUCED 30-DAY READMISSION RATES FOR ACUTE DECOMPENSATED HEART FAILURE
Authors: Nishant Jain, Talha Anwar, Nimai Patel, Emma G. Albert-Stone, Anthony Dils, Thomas Cascino, Matthew Konerman, Todd M. Koelling, Adam Stein, Elizabeth Spranger, Lauren Heidemann
Journal: Journal of the American College of Cardiology (2023)
COMPARISON OF COST BETWEEN PERCUTANEOUS VASCULAR CLOSURE COMPARED TO MANUAL COMPRESSION IN ATRIAL FIBRILLATION ABLATION: SECONDARY ANALYSIS OF A RANDOMIZED CLINICAL TRIAL.
Authors: Rand Ibrahim, Evan Blank, Neal K. Bhatia, Anand D. Shah, Stacy Westerman, David B. De Lurgio, Christine Tompkins, Anshul M. Patel, Angel R. Leon, Faisal M. Merchant, Mikhael Faris El Chami, Michael Shane Lloyd, Soroosh Kiani
Journal: Journal of the American College of Cardiology (2023)
CLINICAL IMPACT OF FORWARD-SOLUTION ECG MAPPING ON PROCEDURE DURATION AND FLUOROSCOPY USE DURING CATHETER ABLATION PROCEDURES
Authors: Avinash Toomu, Frederick T. Han, Gordon Ho, Sutton R. Fox, Kevin Sung, Kurt S. Hoffmayer, Jonathan Chong Hsu, Farshad Raissi Shabari, Gregory K. Feld, David E. Krummen
Journal: Journal of the American College of Cardiology (2023)
IVABRADINE AS SALVAGE THERAPY FOR ATRIAL FIBRILLATION WITH RAPID VENTRICULAR RATE
Authors: Abdullah Yesilyaprak, Jahanavi Ramakrishna, Hussein Tahanulqiwa, Kevser Akyuz, Tripti Nagar, Ashwin Kumar, Nishit Arvind Choksi, Vesna Tegeltija
Journal: Journal of the American College of Cardiology (2023)
CARDIAC MAGNETIC RESONANCE IMAGING TO STUDY THE RELATION BETWEEN LEFT ATRIAL FIBROSIS AND LEFT ATRIAL APPENDAGE FIBROSIS IN ATRIAL FIBRILLATION PATIENTS.
Authors: Luuk Hopman, Irene M. Frenaij, Jose Alonso Solis-Lemus, Sulayman El Mathari, Pranav Bhagirath, Steven Niederer, Marc Gotte
Journal: Journal of the American College of Cardiology (2023)
PREVALENCE OF DISEASE-ASSOCIATED CARDIOMYOPATHY GENE VARIANTS IN ETHNIC MINORITIES WITH ATRIAL FIBRILLATION
Authors: Michael C. Hill, Brandon Chalazan, David Tofovic, Yining Chen, Anish Shah, Miles Barney, Annette Diaz, Sreenivas Konda, Dawood Darbar
Journal: Journal of the American College of Cardiology (2023)
THE EFFECTS OF EMPAGLIFLOZIN AND ORAL KETONE ESTER ON CARDIAC FUNCTION, STRUCTURE, AND METABOLISM IN HEART FAILURE WITH PRESERVED EJECTION FRACTION
Authors: Salva Yurista, William Jiang, Robert Eder, Shi Chen, Feiyang Liu, Jonah Weigand-Whittier, David Guarin Bedoya, Yi-Fen Yen, Christopher Nguyen
Journal: Journal of the American College of Cardiology (2023)
WHO ARE WE MISSING? REPORTING OF TRANSGENDER AND GENDER EXPANSIVE POPULATIONS IN CLINICAL TRIALS
Authors: Eli Rice, Roy Lan, Julio Nunes, Rushil Shah, Melvin R. Echols, Mitchell Lunn, Lin Bryant, Eldrin F. Lewis, Christopher Awad, Muhammed Y. Idris, Kira Clark, Vyjeyanthi Periyakoil, Erin Rose Cruz, Jonathan Chen, Cati Brown-Johnson, Latha P. Palaniappan, Paul J. Wang
Journal: Journal of the American College of Cardiology (2023)
VALUE OF GENOTYPING AND SCAR-PHENOTYPING FOR VT ABLATION PROCEDURESIN PATIENTS WITH NONISCHEMIC LEFT VENTRICULAR CARDIOMYOPATHIES
Authors: Michael Ghannam, Boldizsar Kovacs, Jackson J. Liang, Emmeline N. Mocorro-Ma, Anil K. Attili, Adam Helms, Rakesh Latchamsetty, Krit Jongnarangsin, Fred Morady, Frank M. Bogun
Journal: Journal of the American College of Cardiology (2023)
LONG-TERM SAFETY AND EFFICACY OF MAVACAMTEN IN PATIENTS (PTS) WITH SYMPTOMATIC OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY (HCM): UPDATED RESULTS FROM THE PIONEER-OLE STUDY
Authors: Ahmad Masri, Steven J. Lester, John Stendahl, Sheila M. Hegde, Amy Sehnert, Ganesh Balaratnam, Shawna Fox, Andrew Wang
Journal: Journal of the American College of Cardiology (2023)
EARLY VERSUS DELAYED CONDUCTION DISEASES POST ALCOHOL SEPTAL ABLATION IN HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY PATIENTS
Authors: Mahmoud Ali, Michael Barkett, Jacob Morgan, Viviana Zlochiver, Lynn Erickson, James Adefisoye, M. Fuad Jan, Suhail Q. Allaqaband, Tanvir K. Bajwa, Arshad Jahangir, A. Jamil Tajik
Journal: Journal of the American College of Cardiology (2023)
COMPARISON OF INTRACARDIAC ECHOCARDIOGRAPHY WITH TRANSESOPHAGEAL ECHOCARDIOGRAPHY FOR LEFT ATRIAL APPENDAGE OCCLUSION: AN UPDATED SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Satyam Krishan, Laila Hashim, Laraib Javed, Janeth Gomez-Perez, Mohamad Khattab, Jehanzeb Khan, Rohaan Muhammad, Jalal Gondal, John Walker Sacco, Canisia Tatah, Shazmah Shahrukh, Fiza Farrukh, Shari Clifton, Bilal Munir, Christopher DeSimone, Abhishek Deshmukh, Zain Ul Abideen Asad
Journal: Journal of the American College of Cardiology (2023)
OBSTRUCTIVE SLEEP APNEA PORTENDS STROKE IN YOUNG INDIVIDUALS WITHOUT ATRIAL FIBRILLATION: A LARGE REGISTRY STUDY
Authors: Brototo Deb, Sunil Vasireddi, Neal K. Bhatia, AJ Rogers, Paul Clopton, Tina Baykaner, Prasanth Ganesan, Ruibin Feng, Zahra Azizi, Sanjiv M. Narayan
Journal: Journal of the American College of Cardiology (2023)
ASSOCIATION OF DEVICE DETECTED ATRIAL AND VENTRICULAR TACHYARRHYTHMIA WITH ADVERSE EVENTS IN PATIENTS WITH AN IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR
Authors: Hassan Abbas, Arwa Younis, Ilan Goldenberg, Scott McNitt, Mehmet K. Aktas, Amole Ojo
Journal: Journal of the American College of Cardiology (2023)
INCIDENCE AND PREDICTORS OF NEW ONSET CARDIOMYOPATHY IN HOSPITALIZED COVID19 PATIENTS UNDERGOING ECHOCARDIOGRAPHY
Authors: Sachin Kumar, Bindesh Ghimire, Raunak M. Nair, Sarah Rikabi, Mohannad Seif, Grant W. Reed, Umesh Khot, Gautam Vinod Shah
Journal: Journal of the American College of Cardiology (2023)
IMPACT OF COMBINED IABP AND PULMONARY ARTERY CATHETER USE IN ACUTE MYOCARDIAL INFARCTION-CARDIOGENIC SHOCK A REAL-WORLD STUDY
Authors: Jorge A. Ortega-Hernández, Hector Gonzalez-Pacheco, Jose Omar Arenas, Rodrigo Gopar-Nieto, Diego Araiza Garaygordobil, Daniel Manzur Sandoval, Salvador Mendoza Garcia, Miguel Angel Espidio Coello, Oscar Arturo Lozano Cruz, Alexandra Arias-Mendoza
Journal: Journal of the American College of Cardiology (2023)
ELECTRIC CARDIOVERSION VS PHARMACOLOGICAL THEN ELECTRIC CARDIOVERSION FOR NEW ONSET ATRIAL FIBRILLATION: A META-ANALYSIS
Authors: Paritosh Prasai, Dhan Shrestha, Eltaib Saad, Angkawipa Trongtorsak, Aarya Adhikari, Suman Gaire, Pabitra Adhikari, Amrit Devkota, Prakash Raj Oli, Jurgen Shtembari, Yub Raj Sedhai, Muhammad Sikander Akbar
Journal: Journal of the American College of Cardiology (2023)
TEMPORAL CHANGES IN VARIOUS ECHOCARDIOGRAPHIC PARAMETERS FOLLOWING SURGICAL MYECTOMY IN SEVERELY SYMPTOMATIC OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY: RESULTS FROM THE PROSPECTIVE SPIRIT-HCM STUDY
Authors: Milind Y. Desai, Natalie Szpakowski, Albree Tower-Rader, Amgad G. Mentias, Barbara A. Bittel, Agostina M. Fava, Maran Thamilarasan, Bo Xu, Nicholas G. Smedira
Journal: Journal of the American College of Cardiology (2023)
VENTRICULAR TACHYCARDIA PREDICTS ATRIAL FIBRILLATION RECURRENCE POST ABLATION: A PROPENSITY SCORE-MATCHED ANALYSIS OF A LARGE PROSPECTIVE STUDY
Authors: Zahra Azizi, Brototo Deb, Ruibin Feng, Prasanth Ganesan, AJ Rogers, Hui Ju Chang, Paul Clopton, Sanjiv M. Narayan
Journal: Journal of the American College of Cardiology (2023)
COMPARATIVE EFFECTIVENESS AND SAFETY OUTCOMES OF REDUCED DOSE DOACS VS WARFARIN: A MULTINATIONAL COHORT STUDY OF INDIVIDUALS WITH AF
Authors: Peter Br⊘nnum Nielsen, Flemming Skj⊘th, Alexander Rieem Dun, Mathias Lilja, Iffat Rahman, Torben Bjerregaard Larsen, Mette S⊘gaard, Sigrun Halvorsen, Erik Lundström, Craig I. Coleman, Thomas Fast, Marcela Rivera
Journal: Journal of the American College of Cardiology (2023)
MISSENSE GENETIC VARIATION OF ICAM1 AND INCIDENT HEART FAILURE: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS
Authors: Ravi B. Patel, Pedro Giro, Jonathan Cunningham, Laura Rasmussen-Torvik, Suzette J. Bielinski, Nicholas Larson, Laura Anne Colangelo, David R. Jacobs, Myron Gross, Alex Reiner, Donald M. Lloyd-Jones, Xiuqing Guo, Kent Taylor, Muthiah Vaduganathan, Wendy S. Post, Alain Bertoni, Christie M. Ballantyne, Amil M. Shah, Brian Claggett, Eric Boerwinkle, Bing Yu, Scott D. Solomon, Sanjiv Jayendra Shah
Journal: Journal of the American College of Cardiology (2023)
THE EFFECT OF MAVACAMTEN TREATMENT FOR SYMPTOMATIC, OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY IN PATIENTS OF OLDER AGE AND LONGER DURATION OF DIAGNOSIS: ANALYSIS OF THE EXPLORER-HCM TRIAL
Authors: Andrew Wang, Neal K. Lakdawala, Theodore P. Abraham, Ester Kim Nilles, Daniel M. Wojdyla, Anjali Tiku Owens, Richard G. Bach, Sara Saberi, Amy Sehnert, Sharon Cresci
Journal: Journal of the American College of Cardiology (2023)
EDG-002, A NOVEL TARGETED SARCOMERE REGULATOR PRESERVES INTRINSIC MYOSIN-MOTOR FUNCTION, BLUNTS HYPERCONTRACTILITY AND ELIMINATES LVOT OBSTRUCTION IN CATS WITH HYPERTROPHIC CARDIOMYOPATHY: IN VITRO AND IN VIVO EVIDENCE
Authors: Joanna Kaplan, Sarah Lehman, Mike Duvall, Molly Madden, Jessica Tolley, Natalie Hawryluk, Stephen Schlachter, Victor Rivas, Carina Jauregui, Amanda Crofton, Samantha Harris, Joshua Aaron Stern, Carlos L. del Rio, Alan Russell, Marc Evanchik
Journal: Journal of the American College of Cardiology (2023)
CANNABIDIOL THERAPY FOR CHRONIC HEART FAILURE PREVENTS CARDIAC PATHOLOGICAL REMODELING IN A NON-ISCHEMIC CARDIOMYOPATHY MURINE MODEL
Authors: Omar Lozano, Gerardo García-Rivas, Martin Ramos, Christian Silva Platas, Judith Bernal-Ramirez, Eduardo Vázquez-Garza, Guillermo Torre-Amione
Journal: Journal of the American College of Cardiology (2023)
DIFFERENCES IN HEART FAILURE-RELATED CARDIOGENIC SHOCK BETWEEN ISCHEMIC AND NONISCHEMIC CARDIOMYOPATHY: DATA FROM THE CRITICAL CARE CARDIOLOGY TRIALS NETWORK
Authors: Jason Feinman, Matthew Ian Tomey, Gregory Serrao, Noah Moss, Maria Ronquillo, Miguel Martillo, Michael G. Palazzolo, Sean Van Diepen, Jason Neil Katz, Erin Ann Bohula, David Berg, David A. Morrow, Umesh K. Gidwani, Evan Leibner
Journal: Journal of the American College of Cardiology (2023)
HYPOCHLOREMIA ON ADMISSION AND MORTALITY RISK IN PATIENTS WITH ACUTE DECOMPENSATED HEART FAILURE: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Thanat Chaikijurajai, Pitchaya Worapongsatitaya, Jakrin Kewcharoen, Ben Ponvilawan, Nipith Charoenngam, Pornthira Mutirangura, Atharva K. Dhole, Tesfatsiyon Ergando, Patompong Ungprasert
Journal: Journal of the American College of Cardiology (2023)
THE MODIFIED RAJAN'S HEART FAILURE (R-HF) RISK SCORE PREDICTS ALL-CAUSE MORTALITY IN PATIENTS HOSPITALIZED FOR HEART FAILURE WITH REDUCED EJECTION FRACTION: A RETROSPECTIVE COHORT STUDY
Authors: Rajesh Rajan, Mohammad A. Al Jarallah, Jeremy Hui, Gary Tse, Jeffrey Shi Kai Chan, Danish Iltaf Satti, Raja H. Al Dashti, Govindan Vijayaraghavan
Journal: Journal of the American College of Cardiology (2023)
OUTCOMES OF ADVANCED ATRIOVENTRICULAR BLOCK IN COVID-19 BY VACCINATION STATUS
Authors: Karina Auristela Gonzalez Carta, Ivan Mendoza, Elirub De Lourdes Mi Rojas Gimon, Igor Morr, Chamia Benchetrit, Susana Blanco, Yolimar Meza, Jose Torres Viera, Elias Jesus Urbaez Martinez, Heliodoro Rodriguez, Francisco Lopez-Jimenez, Carmen Militza Terzic, Ivan J. Mendoza Mujica
Journal: Journal of the American College of Cardiology (2023)
LOW VOLTAGE AREA GUIDED SUBSTRATE MODIFICATION IN PERSISTENT ATRIAL FIBRILLATION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Abdelmoniem Moustafa, Omar Kahaly, Ahmed Elzanaty, Chandramohan Meenakshisundaram, Saima Karim, Bernard Abi-Saleh, Ehab Ahmed Eltahawy, Paul Chacko
Journal: Journal of the American College of Cardiology (2023)
INTERLEUKIN-1β INDUCES CARDIAC DYSFUNCTION ASSOCIATED WITH INCREASED EXPRESSION OF PHOSPHOINOSITIDE-3 KINASEγ IN CARDIOMYOCYTES
Authors: Pratyush Narayan, Benjamin W. Van Tassell, Eleonora Mezzaroma, Nadia Martinez Naya, Antonio Abbate, stefano toldo
Journal: Journal of the American College of Cardiology (2023)
THE EFFECTS OF SGLT2 INHIBITION IN PATIENTS HOSPITALIZED WITH ACUTE HEART FAILURE
Authors: Jesus Diaz Acevedo, Jonathan Hu, Anson Yoong-Chee Lee, Kelly Watanabe, Jason Seto, Adela Castro, Mahsheed Khajavi, Jesus Pino Moreno
Journal: Journal of the American College of Cardiology (2023)
COMPLICATIONS ASSOCIATED WITH LEAD EXTRACTION IN DEVICE RELATED INFECTIONS: ANALYSIS OF THE NATIONAL INPATIENT SAMPLE 2016-2019
Authors: Mouna Kodali, Ramtej Atluri, Sami Shoura, Ufuk Vardar, Meghana Vallabhaneni, Sreeram Yalamanchili
Journal: Journal of the American College of Cardiology (2023)
A SYSTEMATIC REVIEW AND META-ANALYSIS OF RHYTHM- VS RATE- CONTROL STRATEGIES IN ATRIAL FIBRILLATION
Authors: Stefanos Zafeiropoulos, Ioannis Doundoulakis, Alexandra Bekiaridou, Ioannis Farmakis, Kristie M. Coleman, George Giannakoulas, Stavros Zanos, Stavros E. Mountantonakis, Stavros Stavrakis
Journal: Journal of the American College of Cardiology (2023)
REDUCTION OF ABNORMAL FDG UPTAKE ON PET/CT IS A PREDICTOR OF ALL-CAUSE MORTALITY IN PATIENTS WITH CARDIAC SARCOIDOSIS
Authors: Toshitaka Okabe, Takeru Nabeta, Yoshihisa Naruse, Tatsunori Taniguchi, Takeshi Kitai, Kenji Yoshioka, Hidekazu Tanaka, Takahiro Okumura, Yuichi Baba, Yuya Matsue
Journal: Journal of the American College of Cardiology (2023)
Obituary—Pieter Van Vlierberghe (1980–2022)
Authors: Malgorzata Dawidowska, Agnieszka Dzikiewicz-Krawczyk, Natalia Rozwadowska, Panagiotis Ntziachristos, Joost Kluiver, Anke van den Berg, Reiner Siebert, Maciej Giefing
Journal: Leukemia (2023)
Identification of specific susceptibility loci for the early-onset colorectal cancer
Authors: Haoxue Wang, Yimin Cai, Meng Jin, Chao Qun Huang, Caibo Ning, Siyuan Niu, Linyun Fan, Bin Li, Ming Zhang, Zequn Lu, Xuesi Dong, Zilin Luo, Rong Zhong, Heng Li, Ying Zhu, Xiaoping Miao, Xiaojun Yang, Jiang Chang, Ni Li, Jianbo Tian
Journal: Genome Medicine (2023)

Abstract Background The incidence of early-onset colorectal cancer (EOCRC; patients &lt; 50 years old) has been rising rapidly, whereas the EOCRC genetic susceptibility remains incompletely investigated. Here, we aimed to systematically identify specific susceptible genetic variants for EOCRC. Methods Two parallel GWASs were conducted in 17,789 CRC cases (including 1490 EOCRC cases) and 19,951 healthy controls. A polygenic risk score (PRS) model was built based on identified EOCRC-specific susceptibility variants by using the UK Biobank cohort. We also interpreted the potential biological mechanisms of the prioritized risk variant. Results We identified 49 independent susceptibility loci that were significantly associated with the susceptibility to EOCRC and the diagnosed age of CRC (both P &lt; 5.0×10 −4 ), replicating 3 previous CRC GWAS loci. There are 88 assigned susceptibility genes involved in chromatin assembly and DNA replication pathways, mainly associating with precancerous polyps. Additionally, we assessed the genetic effect of the identified variants by developing a PRS model. Compared to the individuals in the low genetic risk group, the individuals in the high genetic risk group have increased EOCRC risk, and these results were replicated in the UKB cohort with a 1.63-fold risk (95% CI: 1.32–2.02, P = 7.67×10 −6 ). The addition of the identified EOCRC risk loci significantly increased the prediction accuracy of the PRS model, compared to the PRS model derived from the previous GWAS-identified loci. Mechanistically, we also elucidated that rs12794623 may contribute to the early stage of CRC carcinogenesis via allele-specific regulating the expression of POLA2 . Conclusions These findings will broaden the understanding of the etiology of EOCRC and may facilitate the early screening and individualized prevention. Graphical Abstract
Ionizable polymeric nanocarriers for the codelivery of bi-adjuvant and neoantigens in combination tumor immunotherapy
Authors: Ting Su, Xiang Liu, Shuibin Lin, Furong Cheng, Guizhi Zhu
Journal: Bioactive Materials (2023)

Ionizable lipid nanocarriers have made historical contribution to COVID-19 mRNA vaccines. Here, we report ionizable polymeric nanoparticles that co-deliver bi-adjuvant and neoantigen peptides for cancer immunotherapy in combination with immune checkpoint blockade (ICB). Current cancer ICB benefits only a small subset of patients, largely due to a lack of pre-existing target cells and checkpoint targets for ICB, tumor antigenic heterogeneity, and tumor immunosuppression. Therapeutic vaccines hold the potential to enhance ICB therapeutic efficacy by expanding antitumor cell repertoires, upregulating immune checkpoint levels and hence sensitizing ICB, and reducing tumor immunosuppression. Chemically defined peptide vaccines are attractive, but their current therapeutic efficacy has been limited due to 1) poor vaccine delivery to immunomodulatory lymph nodes (LNs) and antigen (Ag)-presenting cells (APCs), 2) poor immunostimulant adjuvant efficacy with restricted target cell subsets in humans, 3) limited adjuvant/Ag codelivery to enhance Ag immunogenicity, and 4) limited ability to overcome tumor antigenic heterogeneity. Here, we developed nanovaccines (NVs) using pH-responsive polymeric micellular nanoparticles (NPs) for the codelivery of bi-adjuvant [Toll-like receptor (TLR) 7/8 agonist R848 and TLR9 agonist CpG] and peptide neoantigens (neoAgs) to draining LNs for efficient Ag presentation in a broad range of APC subsets. These NVs potentiated the immunogenicity of peptide Ags and elicits robust antitumor T cell responses with memory, and remodeled the tumor immune milium with reduced tumor immunosuppression. As a result, NVs significantly enhanced ICB therapeutic efficacy for murine colorectal tumors and orthotopic glioblastoma multiforme (GBM). These results suggest marked potential of bi-adjuvant/neoAg-codelivering NVs for combination cancer immunotherapy.