tbuckley/cabot-search huggingface dataset:
An Epitome of Hydrotherapy for Physicians, Architects and Nurses.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Does the fly matter in trout fishing?
Journal: BMJ (1999)

Intranasal corticosteroids in allergic rhinitis Paper did not include all data on adverse effectsEditor-Weiner et al conclude that "results from [their] systematic review, together with data on safety and cost effectiveness, support the use of intranasal corticosteroids over oral antihistamines as first line treatment for allergic rhinitis." 1 They also state that "intranasal corticosteroids are considered safe [and] studies have failed to show significant effects on serum markers of bone metabolism and short term bone growth," referring to two studies, those by Martinati et al and Wolthers et al.They make no reference to two more recent studies, both of a larger number of subjects over longer periods, which established a significant reduction in paediatric bone growth. 2 3The issue of adverse effects was also addressed in a report by the Committee on Safety of Medicines and Medicines Control Agency, which concluded that intranasal corticosteroids can cause "clinically important systemic adverse effects at licensed doses." 4 The United Kingdom datasheet for Beconase aqueous nasal spray (beclomethasone dipropionate) recognises the potential for children to develop growth retardation at licensed doses and the need to refer patients to paediatric specialists while they are being prescribed intranasal corticosteroids (Allen and Hanburys, Sept 1998).I question the omission of such key data from Weiner et al's systematic review; it may well tip the risk:benefit ratio away from the use of intranasal corticosteroids in children and, hence, affect the validity of the review's conclusions.
Survival in Acute Non-Lymphocytic Leukaemia following Breast Cancer
Authors: S D Kaster, F F Holmes
Journal: Journal of the Royal Society of Medicine (1990)

Acute non-lymphocytic leukaemia (ANLL) occurs with increased frequency in women with previously diagnosed breast cancer. Adjuvant radiotherapy and chemotherapy are related to this increase. We studied the interrelationships among age at breast cancer diagnosis, interval to ANLL diagnosis, and survival in 54 women of whom 11 were from Kansas and 43 were from two other published series. Median age at breast cancer diagnosis was 50.5 years, median interval to ANLL diagnosis was 4.8 years, and median survival after ANLL diagnosis was 2.2 months. Increasing age was associated with a decrease of the interval to ANLL diagnosis just short of statistical significance (P=0.0591). There was no association of survival with either age or the interval to ANLL diagnosis. With an increase in the use of adjuvant therapy in breast cancer there is a need to identify women at greatest risk of subsequently developing ANLL, at present not possible.
Activated protein C and pulmonary embolism
Authors: Ian Roberts, Zahir Amoura, Thomas Papo, Jean-Charles Piette, H. Bounameaux, S. Desmarais, G. Reber, A. Perrier, P. de Moerloose, M. Bazzan, E. Aluffi, A. Vaccarino, P. Schinco, B. Montaruli
Journal: The Lancet (1996)
Prostate Adenocarcinoma in Rats: Induction by 3,2′-Dimethyl-4-aminobiphenyl&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;,&lt;xref ref-type="fn" rid="fn3"&gt;3&lt;/xref&gt;,&lt;xref ref-type="fn" rid="fn4"&gt;4&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1982)

Five experiments designed for various purposes [mainly for the study of colon carcinogenesis in inbred F344 male rats given sc injections of 3,2′-dimethyl-4-aminobiphenyl (DMAB)] were reviewed as to the production and presence of neoplastic lesions of the prostate gland. The overall incidence of prostate proliferative lesions among 293 animals exposed to DMAB was 32% (95 animals). Early in situ carcinomas were present in 66 animals, larger intra-acinar carcinomas in situ in 28, and invasive carcinoma in 1. None of the control animals in these studies exhibited prostate neoplasms. The conclusion, therefore, is that DMAB can induce adenocarcinomas in the rat prostate gland.
Highlights of This Issue
Journal: Clinical Cancer Research (2013)

Jiang and colleagues identify a molecular mechanism that provides the basis for BRAF inhibitor-resistant melanoma cells to evade the immune system via upregulation of the inducible ligand programmed death-1-ligand 1.In addition, a potential molecular means to reverse this through MEK inhibition is described.These findings have implications for therapeutic strategies in the development of targeted combinations as well as combinations of targeted small molecules and immune checkpoint blockade.
Medical preparedness: the Olympic watchwords
Authors: Phil Gunby
Journal: JAMA (1979)

The first radio message came into the Lake Placid (NY) Olympic Medical Operations Center at 9 AM from the ski jump area 1.6 km away. It was bad news. New York National Guard medical personnel at the scene radioed that a competitor had lost her balance while executing a 90-m jump in the Olympic ski competition. She landed head-first in the snow, was unconscious for about two minutes, and now said that she could not move her arms or legs, which felt numb. The examining physician suspected a cervical fracture and requested evacuation by helicopter to the University of Vermont Medical Center in Burlington, about 30 minutes away by air. While Lake Placid Olympic Organizing Committee, National Guard, and Army medical and communications experts were coping with the problem, another radio call crackled through from the base of Whiteface Mountain, 16 km away. A spectator at the alpine
Awards, Appointments, Announcements
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Awards, Appointments, Announcements Get access JNCI: Journal of the National Cancer Institute, Volume 83, Issue 12, 19 June 1991, Pages 824–826, https://doi.org/10.1093/jnci/83.12.824 Published: 19 June 1991
Surgery of the Aged and Debilitated Patient.
Journal: Annals of Internal Medicine (1968)

The subject matter is presented as case histories in the clinico-pathological conference format with the cases grouped in six categories: Congenital Anomalies, Trauma, Infection, Vascular Anomalies, Degenerative Diseases, and Diseases of Unknown Etiology.With a few exceptions, the subject matter is restricted to cases from the Montefiore Hospital and Medical Center.As a result, some clinical syndromes are not included.Although it is not an all inconclusive review of the entire neuroradiology field, it does cover the more important aspects with good clinical and neuropathological correlation.Also included in the discussion of some cases are the indications and contraindications for some of the diagnostic and surgical procedures and therapeutic ap- proaches.It must be recognized by the reader that the views expressed represent opinions and experiences of the authors, all recognized authorities in their respective fields, but are not necessarily always in agreement with other authorities.Of course, this is to be expected and, in fact, makes the book more interesting.Newer diagnostic aids, such as radioisotope scans, echoencephalography, and subtraction techniques were not included, since most of the cases were seen and recorded at a time when these newer diagnostic aids were still in the early development stage and had not been adequately evaluated.All cases have accompanying pertinent radiographic reproductions and many also have gross and microscopic pathological illustrations.Although some of the radio- graphic reproductions are of excellent quality, many are only fair and some are rather poor.At least a moderate degree of prior neuroradiographic knowledge is required for the reader to appreciate many of these illustrations.The bibliography is quite limited, and the index only fair.These deficiencies are inherent in the organizational for- mat, of course.
Viruses and Renal Carcinoma of &lt;italic&gt;Rana pipiens&lt;/italic&gt;. V. Effect of Frog Virus 3 on Developing Frog Embryos and Larvae&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Kenyon Tweedell, Allan Granoff
Journal: JNCI Journal of the National Cancer Institute (1968)

Frog virus 3 was injected into developing Rana pipiens embryos and larvae. Tailbud- and hatching-stage embryos were dead within 15 days after inoculation. The time of death was dose-dependent. Larvae (17–26 mm) were killed by 3 × 106 plaque-forming units, but survived 105 units. Survivors carried through metamorphosis did not develop renal tumors.
Inappropriate Testing for Diarrheal Diseases in the Hospital
Authors: Don L. Siegel
Journal: JAMA (1990)

To assess the degree to which routine stool cultures, ova and parasite examinations, and<i>Clostridium difficile</i>toxin assays may be inappropriately ordered on hospitalized patients, we conducted a retrospective study to determine the relative yield of these tests on specimens collected from outpatients and inpatients as a function of time after admission. During a 3-year period, only 1 of 191 positive stool cultures and none of the 90 ova and parasite examinations with positive results were from the group of patients who had stool specimens submitted after 3 days of hospitalization. Analysis of laboratory work load for a 1-year period showed that specimens from this patient group contributed nearly 50% of the more than 3000 specimens received each year. In contrast, approximately 25% (range, 17% to 33%) of samples, regardless of admission status, were positive for C<i>difficile</i>toxin. Eliminating routine stool cultures and ova and parasite examinations on hospitalized patients would significantly reduce hospital and patient costs without altering patient care. Nationwide, such a policy might achieve a cost savings of $20 to $30 million per year. (<i>JAMA</i>. 1990;263:979-982)
CHLOROQUINE RETINOPATHY
Authors: J R Jacobsen
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of Renal Transplant Function by Iodohippurate Sodium I 131
Authors: M. Donald Blaufox
Journal: JAMA (1967)

Iodohippurate sodium I 131 clearances were used to evaluate renal function in 15 patients after transplantation. The iodohippurate clearance was found to be of prognostic value if performed during the first day after transplantation. In addition, it was helpful in evaluating renal function and detecting renal transplant rejection, especially during the first four weeks following surgery.
Osteomyelitis: Its Pathogenesis, Symptomatology and Treatment
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sodium Bicarbonate Administration During Cardiac Arrest
Authors: Richard L. Bishop
Journal: JAMA (1976)

Arterial pH, Pco<sub>2</sub>, and osmolality were determined serially during cardiac resuscitation in patients and in dogs, with and without administration of sodium bicarbonate. These studies demonstrate that (1) in the absence of preexisting acidosis, severe acidosis can be prevented by adequate ventilation alone; (2) sodium bicarbonate administration results in a significant rise in arterial Pco<sub>2</sub>, which parallels the rise in pH despite adequate ventilation; (3) during prolonged cardiac arrest and resuscitation, there is a rise in arterial osmolality that is accentuated by sodium bicarbonate. These studies suggest that sodium bicarbonate should not be used during resuscitation (1) in the absence of effective hyperventilation or where carbon dioxide removal is inadequate despite adequate ventilation, (2) in repeated doses, without confirmation of substantial acidosis, or (3) when cardiac arrest has been of brief duration and preexisting acidosis is unlikely. These studies also point to the need for a reappraisal of other buffers that do not elevate the arterial Pco<sub>2</sub>. (<i>JAMA</i>235:506-509, 1976)
Incorporating Prevention in Managed Care
Authors: George A. Gellert
Journal: JAMA (1993)

<h3>To the Editor.</h3> —There is much interest in managed care across the United States at present.<sup>1,2</sup>While definitions of managed care vary, many proposals include several common elements, in particular, reorganizing health services to provide more comprehensive coverage and access to care while containing cost. Several jurisdictions are organizing health system authorities that would involve contracts with primary care providers, including physicians, clinics, hospitals, health maintenance organizations, and other providers. Most managed care strategies have been conceptualized and are starting to be operationalized based on largely economic analyses. From a population perspective, managed care should seek to assure improved provision of preventive as well as curative services. This implies assuring that prevention is as valued a clinical activity as the provision of curative medical services. A major problem with the existing health care system is that there is no equity in the remuneration of practitioners engaged in disease prevention
Inhibition of the Activity of Mouse Natural Killer Cells by Urethan&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Eliezar Gorelik, Ronald B. Herberman
Journal: JNCI Journal of the National Cancer Institute (1981)

The effect of the carcinogen urethan on the natural killer (NK) activity of spleen cells from inbred A/J mice was studied. Urethan (1 mg/g) inoculated into 6- to 8-week-old A/J mice produced considerable depression of cytotoxic activity of spleen cells against YAC-1 or RL♂1 tumor cells. This effect was biphasic. Initial depression of NK activity was observed 1 day after urethan treatment, reactivity normalized at 4 days, and then a second, more profound depression was seen around 7–8 days, which presisted for 14–18 days. In contrast, lymphoproliferative responses of spleen cells to mitogens were only transiently depressed after urethan treatment and were in the normal range during the second period of marked depression of NK activity. Urethan appeared to have an even more profound effect on NK activity when given to very young mice (5–17 days old). After one or two injections of urethan, very low splenic NK activity was found 6 and 7 weeks later. The carcinogenic effects of urethan were also more striking in these young recipients, with multiple tumors observed in the lungs at the time of cytotoxicity testing. Inoculation of adult urethan-treated mice with the interferon inducer polyinosinic-polycytidylic acid, boosted NK activity to the same extent as seen with normal mice, which suggested that pre-NK cells are resistant to the effects of urethan. The present data agree with the hypothesis that the ability of a chemical to depress NK cell activity is an important factor in its carcinogenic activity.
Study shows little effect of steroids in spinal injury
Authors: Phil Gunby
Journal: JAMA (1982)

Despite widespread use of steroids to treat spinal cord injuries, high doses of the agents may have negligible effects, at least in the first six weeks. This preliminary report comes from a randomized, collaborative study, supported by the National Institute of Neurological and Communicative Disorders and Stroke (NINCDS), Bethesda, Md, concerning the possible benefits of two different dosage levels of corticosteroids in treating such injuries. However, principal investigator Michael B. Bracken, PhD, points out that the patients involved will be evaluated further at six months and one year after their injuries. Bracken, a senior research associate and lecturer in epidemiology at Yale University School of Medicine, New Haven, Conn, explained the investigation this way at the annual Honolulu meeting of the American Association of Neurological Surgeons: The study involves 330 patients, in all of whom 11 days of intravenous steroid therapy was started in the emergency department. Half received a
Coexistence of psoriasis and an unusual IgG-mediated subepidermal bullous dermatosis: identification of a novel 200-kDa lower lamina lucida target antigen
Authors: K-R. CHEN, S. SHIMIZU, S. MIYAKAWA, A. ISHIKO, H. SHIMIZU, T. HASHIMOTO
Journal: British Journal of Dermatology (1996)

Journal Article Coexistence of psoriasis and an unusual IgG‐mediated subepidermal bullous dermatosis: identification of a novel 200‐kDa lower lamina lucida target antigen Get access K‐R. CHEN, K‐R. CHEN Division of Dermatology, Kawasaki City Hospital 12‐1 Shinkawadoori, Kawasaki‐ku, Kawasaki 210, Japan Search for other works by this author on: Oxford Academic Google Scholar S. SHIMIZU, S. SHIMIZU Division of Dermatology, Kawasaki City Hospital 12‐1 Shinkawadoori, Kawasaki‐ku, Kawasaki 210, Japan Search for other works by this author on: Oxford Academic Google Scholar S. MIYAKAWA, S. MIYAKAWA Division of Dermatology, Kawasaki City Hospital 12‐1 Shinkawadoori, Kawasaki‐ku, Kawasaki 210, Japan Search for other works by this author on: Oxford Academic Google Scholar A. ISHIKO, A. ISHIKO Division of Dermatology, Nippon Kokan Hospital, 1‐2‐1 Kokandoori, Kawasaki‐ku, Kawasaki 210, Japan Search for other works by this author on: Oxford Academic Google Scholar H. SHIMIZU, H. SHIMIZU Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku‐ku, Tokyo 160, Japan Search for other works by this author on: Oxford Academic Google Scholar T. HASHIMOTO T. HASHIMOTO Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku‐ku, Tokyo 160, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 134, Issue 2, 1 February 1996, Pages 340–346, https://doi.org/10.1111/j.1365-2133.1996.tb07625.x Published: 01 February 1996 Article history Accepted: 28 February 1995 Published: 01 February 1996
Strategies to Reduce Cigarette Sales
Authors: Alan Blum
Journal: JAMA (1986)

CIGARETTES are among the highest taxed consumer products. In the United States, one third of receipts from civilian retail cigarette sales goes to federal, state, and local treasuries in the form of excise or sales tax, and in fiscal year 1984, the federal government's share of $10.1 billion in tax revenue was greater than $4.7 billion.<sup>1</sup>Yet in view of the enormous cost of smoking-induced illness (estimated by health economists to be between $39 and $55 billion per year, or a minimum of 10% of the national outlay for health care<sup>2</sup>), it is hard to believe that cigarette taxes are not specifically earmarked for health care, much less to discourage smoking. Indeed, if the recent year-long debate in Congress over whether to retain the 16-cent federal tax is any indication, then there is little doubt that the government sees cigarette taxes solely as a means for deficit reduction.
Continuing education program
Journal: CA A Cancer Journal for Clinicians (2009)

After completing this activity, the learner should be able to:• Identify the physiology of the lymph system, the pathophysiology of lymphedema, and its causes.• Describe stages, severity, and characteristics of cancer treatment-related lymphedema.• Discuss the management of lymphedema.• Identify approaches to the prevention of lymphedema.The ACS designates this educational activity for a maximum of one AMA PRA Category 1 Credit™.Physicians should only claim credit commensurate with the extent of their participation in the activity. An application has been
Awards, Appointments, Announcements
Journal: JNCI Journal of the National Cancer Institute (1993)

Awards, Appointments, Announcements Get access JNCI: Journal of the National Cancer Institute, Volume 85, Issue 17, 1 September 1993, Pages 1375–1376, https://doi.org/10.1093/jnci/85.17.1375-a Published: 01 September 1993