Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis
Authors: Ferenc E Mózes, Jenny A Lee, Yasaman Vali, Osama Alzoubi, Katharina Staufer, Michael Trauner, Rafael Paternostro, Rudolf E Stauber, Adriaan G Holleboom, Anne-Marieke van Dijk, Anne Linde Mak, Jérôme Boursier, Marc de Saint Loup, Toshihide Shima, Elisabetta Bugianesi, Silvia Gaia, Angelo Armandi, None Shalimar, Monica Lupșor-Platon, Vincent Wai-Sun Wong, Guanlin Li, Grace Lai-Hung Wong, Jeremy Cobbold, Thomas Karlas, Johannes Wiegand, Giada Sebastiani, Emmanuel Tsochatzis, Antonio Liguori, Masato Yoneda, Atsushi Nakajima, Hannes Hagström, Camilla Akbari, Masashi Hirooka, Wah-Kheong Chan, Sanjiv Mahadeva, Ruveena Rajaram, Ming-Hua Zheng, Jacob George, Mohammed Eslam, Salvatore Petta, Grazia Pennisi, Mauro Viganò, Sofia Ridolfo, Guruprasad Padur Aithal, Naaventhan Palaniyappan, Dae Ho Lee, Mattias Ekstedt, Patrik Nasr, Christophe Cassinotto, Victor de Lédinghen, Annalisa Berzigotti, Yuly P Mendoza, Mazen Noureddin, Emily Truong, Céline Fournier-Poizat, Andreas Geier, Miljen Martic, Theresa Tuthill, Quentin M Anstee, Stephen A Harrison, Patrick M Bossuyt, Michael Pavlides, Quentin M Anstee, Ann K Daly, Olivier Govaere, Simon Cockell, Dina Tiniakos, Pierre Bedossa, Alastair Burt, Fiona Oakley, Heather J Cordell, Christopher P Day, Kristy Wonders, Paolo Missier, Matthew McTeer, Luke Vale, Yemi Oluboyede, Matt Breckons, Patrick M Bossuyt, Hadi Zafarmand, Yasaman Vali, Jenny Lee, Max Nieuwdorp, Adriaan G Holleboom, Joanne Verheij, Vlad Ratziu, Karine Clément, Rafael Patino-Navarrete, Raluca Pais, Valerie Paradis, Detlef Schuppan, Jörn M Schattenberg, Rambabu Surabattula, Sudha Myneni, Beate K Straub, Toni Vidal-Puig, Michele Vacca, Sergio Rodrigues-Cuenca, Mike Allison, Ioannis Kamzolas, Evangelia Petsalaki, Mark Campbell, Chris J Lelliott, Susan Davies, Matej Orešič, Tuulia Hyötyläinen, Aiden McGlinchey, Jose M Mato, Óscar Millet, Jean-François Dufour, Annalisa Berzigotti, Mojgan Masoodi, Michael Pavlides, Stephen Harrison, Stefan Neubauer, Jeremy Cobbold, Ferenc Mozes, Salma Akhtar, Seliat Olodo-Atitebi, Rajarshi Banerjee, Matt Kelly, Elizabeth Shumbayawonda, Andrea Dennis, Anneli Andersson, Ioan Wigley, Manuel Romero-Gómez, Emilio Gómez-González, Javier Ampuero, Javier Castell, Rocío Gallego-Durán, Isabel Fernández, Rocío Montero-Vallejo, Morten Karsdal, Daniel Guldager Kring Rasmussen, Diana Julie Leeming, Antonia Sinisi, Kishwar Musa, Estelle Sandt, Manuela Tonini, Elisabetta Bugianesi, Chiara Rosso, Angelo Armandi, Fabio Marra, Amalia Gastaldelli, Gianluca Svegliati, Jérôme Boursier, Sven Francque, Luisa Vonghia, Ann Driessen, Mattias Ekstedt, Stergios Kechagias, Hannele Yki-Järvinen, Kimmo Porthan, Johanna Arola, Saskia van Mil, George Papatheodoridis, Helena Cortez-Pinto, Cecilia M P Rodrigues, Luca Valenti, Serena Pelusi, Salvatore Petta, Grazia Pennisi, Luca Miele, Andreas Geier, Christian Trautwein, Johanna Reißing, Guruprasad P Aithal, Susan Francis, Naaventhan Palaniyappan, Christopher Bradley, Paul Hockings, Moritz Schneider, Philip Newsome, Stefan Hübscher, David Wenn, Christian Rosenquist, Aldo Trylesinski, Rebeca Mayo, Cristina Alonso, Kevin Duffin, James W Perfield, Yu Chen, Carla Yunis, Theresa Tuthill, Magdalena Alicia Harrington, Melissa Miller, Yan Chen, Euan James McLeod, Trenton Ross, Barbara Bernardo, Corinna Schölch, Judith Ertle, Ramy Younes, Anouk Oldenburger, Harvey Coxson, Rachel Ostroff, Leigh Alexander, Hannah Biegel, Mette Skalshøi Kjær, Lea Mørch Harder, Peter Davidsen, Jens Ellegaard, Maria-Magdalena Balp, Clifford Brass, Lori Jennings, Miljen Martic, Jürgen Löffler, Douglas Applegate, Sudha Shankar, Richard Torstenson, Daniel Lindén, Céline Fournier-Poizat, Anne Llorca, Michael Kalutkiewicz, Kay Pepin, Richard Ehman, Gerald Horan, Gideon Ho, Dean Tai, Elaine Chng, Scott D Patterson, Andrew Billin, Lynda Doward, James Twiss, Paresh Thakker, Zoltan Derdak, Henrik Landgren, Carolin Lackner, Annette Gouw, Prodromos Hytiroglou
Journal: The Lancet. Gastroenterology & hepatology (2023)

Histologically assessed liver fibrosis stage has prognostic significance in patients with non-alcoholic fatty liver disease (NAFLD) and is accepted as a surrogate endpoint in clinical trials for non-cirrhotic NAFLD. Our aim was to compare the prognostic performance of non-invasive tests with liver histology in patients with NAFLD.