tbuckley/cabot-search huggingface dataset:
Cerebrospinal Fluid Levels of 2′-Deoxycoformycin After Systemic Administration in Monkeysl&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1982)

Journal Article Cerebrospinal Fluid Levels of 2′-Deoxycoformycin After Systemic Administration in Monkeysl Get access Julie Blatt, Julie Blatt Search for other works by this author on: Oxford Academic PubMed Google Scholar Peter M. Venner, Peter M. Venner Search for other works by this author on: Oxford Academic PubMed Google Scholar Riccardo Riccardi, Riccardo Riccardi Search for other works by this author on: Oxford Academic PubMed Google Scholar Lawrence F. Cohen, Lawrence F. Cohen Search for other works by this author on: Oxford Academic PubMed Google Scholar Diamon Gangji, Diamon Gangji Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert I. Glazer, Robert I. Glazer Search for other works by this author on: Oxford Academic PubMed Google Scholar David G. Poplack David G. Poplack Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 68, Issue 3, March 1982, Pages 391–393, https://doi.org/10.1093/jnci/68.3.391 Published: 01 March 1982 Article history Received: 22 April 1981 Accepted: 22 October 1981 Published: 01 March 1982
Use and Abuse of Benzodiazepines
Authors: James H. Woods
Journal: JAMA (1988)

THE WIDESPREAD use of benzodiazepines has been a source of concern and debate, due in large part to the traditional association of "mood-altering" or sedating drugs with problems of abuse and dependence. Such problems have indeed been reported with the benzodiazepines, and the view has emerged that abuse and dependence might account for a substantial proportion of benzodiazepine use. On the other hand, many investigators<sup>1-5</sup>have found that most use of benzodiazepines is appropriate to the prevalence of the medical and psychiatric conditions for which they are deemed effective. Physicians prescribing these drugs are faced with the need to weigh the potential risk to their patients against the drugs' demonstrated benefit in the treatment of anxiety and insomnia. We have recently conducted a comprehensive review of the extensive experimental, clinical, and epidemiologic literature pertinent to the use and abuse of benzodiazepines.<sup>6</sup>Our review indicates that these two predominant
Current Medical Literature
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Priapism and Painless Hematuria In Hemoglobin C Trait
Authors: Mason G. Robertson
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Sickle cell disease (homozygous SS disease) is well known as a cause of priapism. Heterozygous sickle cell trait is well known to be associated with painless hematuria. It is perhaps of more than passing interest that we have seen two patients with hemoglobin C trait, one suffering from priapism, the other suffering from intermittent painless hematuria. The first patient was a 49-year-old muscular, healthy appearing black man, who, in March of 1967, awakened one morning with priapism. He was admitted by T. S. Su, MD, urologist, to Memorial Medical Center of Chatham County, and underwent a cavanocaval shunt. A subsequent medical evaluation revealed that the patient suffered from essential hypertension, but had no other significant abnormalities. A starch gel hemoglobin electrophoresis showed hemoglobin A value of 70% and hemoglobin C value of 30%. Our laboratory had reported a positive sickle cell preparation, and Dr. Robert M. Bookchin
Highlights of This Issue
Journal: Clinical Cancer Research (2010)

The serine/threonine kinase GSK-β is a positive regulator of human cancer cell survival and proliferation. To explore the role of GSK-β in bladder cancer, Naito and colleagues determined the subcellular localization of GSK-β and evaluated the effect of GSK-3 inhibition. Nuclear accumulation of GSK-β was strongly associated with high-grade tumors, metastasis, and lower survival rates in bladder cancer patients. Further, inhibition of GSK-β suppressed proliferation and survival of bladder cancer cells. These results identify nuclear accumulation of GSK-β as a novel prognostic marker in bladder cancer, and suggest GSK-β as a potential therapeutic target in urothelial carcinoma.Prognostic and chemotherapy predictive biomarkers are needed for melanoma. In this study, Jewell and colleagues performed gene expression profiling of formalin-fixed primary melanoma tumors. They found that DNA repair genes, predominantly involved in double-strand break repair, were over-expressed in tumors from patients with reduced relapsefree survival, and in tumors with higher mitotic rate. Analysis of a subset of patients treated with chemotherapy (predominantly dacarbazine) revealed that DNA repair genes were over-expressed in tumors from patients unresponsive to chemotherapy. These findings highlight the importance of upregulation of DNA repair processes during melanoma progression and indicate a potential role in chemoresistance.Carr and colleagues performed a phase II trial of continuous dosing of sunitinib in patients with advanced thyroid cancer to determine disease response and toxicity. Also, an exploratory analysis of FDG-PET imaging after seven days of therapy was performed to determine if disease response could be predicted. Of 33 patients, 10 had partial responses and 16 had stable disease. Patients with RECIST response and stable disease had a significant decline in average SUVs compared to patients with progressive disease. These results suggest that FDG-PET imaging may help identify patients unlikely to respond to tyrosine kinase inhibitor therapy.Clinically useful predictors of response to specific chemotherapy regimens in breast cancer are needed. Tabchy and colleagues tested a 30- gene predictor of pathologic complete response to neoadjuvant paclitaxel and fluorouracil, doxorubicin, cyclophosphamide (T/FAC) chemotherapy from fine-needle biopsies of breast cancers in a prospective randomized trial. The authors found that the 30-gene predictor could identify patients with greater than average sensitivity to T/FAC chemotherapy but not to FAC treatment. To improve their clinical utility, second generation genomic predictors should be developed separately for different molecular subsets of breast cancers.
Acute Infectious Diseases: A Handbook for Practitioners and Students
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lymphadenectomy for Testicular Tumors
Authors: William L. Caldwell
Journal: JAMA (1971)

<h3>To the Editor.—</h3> The recent paper on retroperitoneal lymphadenectomy for testicular tumors by Walsh et al (<b>217</b>:309, 1971) reported excellent results which undoubtedly represent maximal survival rates possible from this procedure, since it is done by individuals with considerable experience and expertise. Several aspects of the report could stand clarification. First, the number of patients explored and found non-resectable is not stated; such patients should clearly be included as failures of the technique. In an earlier report from Walter Reed Army Hospital by Patton and Mallis, 31 of 162 patients were found to have nonresectable disease in the retroperitoneal space. Surely, the UCLA experience must include some patients with nonresectable disease. Only a fourth of the patients (16) received postoperative irradiation. How these 16 patients were selected from the 35 patients with involved lymph nodes at the time of adencetomy is not stated. In the absence of this information
A Great Leap Backward in the Treatment of Carcinoma of the Breast
Authors: C. D. Haagensen
Journal: JAMA (1973)

In 1863 Sir James Paget, one of the foremost surgeons of his time and an authority on the treatment of breast cancer, wrote, "I am not aware of a single clear instance of the recovery, that is, as that the patient should live more than ten years free of disease...." Paget, like other surgeons of his time, treated breast cancer by the local removal of the primary breast tumor, together with a limited margin of the surrounding breast tissue. But the generation of surgeons following Paget—Charles H. Moore in London, Richard von Volkmann in Halle, and Samuel W. Gross in Philadelphia—had the vision and the courage to attack the disease more vigorously, removing the entire breast, the pectoral fascia, and the axillary lymph nodes. Occasional long-term survival was achieved, but local recurrence developed in 65%. Then in 1882, Halsted began performing the first true radical mastectomy, which included sacrifice of
Highlights from Recent Cancer Literature
Journal: Cancer Research (2011)

Cooperation between Casein Kinase Ia and p53The Wnt signaling pathway is mutationally activated in colorectal cancer, resulting in stabilization of b-catenin, which subsequently translocates to the nucleus and activates a cancer-promoting transcriptional program.At baseline, b-catenin is part of a cytoplasmic destruction complex, with proteins including APC, Axin, and casein kinase Ia (CKIa) contributing to its steady-state degradation.Although much is known about APC and Axin, the role of CKIa in this destruction complex remains poorly understood.Elyada and colleagues generated mice deleted for CKI, resulting in an embryonic lethal phenotype.In floxed mice with deletion limited to intestinal epithelium instead, stabilization of b-catenin and activation of Wnt signaling were achieved without development of gastrointestinal tumors.Because loss of p53 is known to contribute to Wnt-driven tumors, the authors went on to generate mice deleted for both genes.Subsequent loss of p53 led to frank gastrointestinal cancers, associated with both extensive proliferation and invasion.The authors identified a p53-suppressed invasion signature, consisting of genes regulating enterocyte polarity, adhesion, tissue remodeling, and motility.CKIa therefore initiates degradation of b-catenin, while p53 blocks extensive proliferation and invasion.Thus, CKIa and p53 cooperate in safeguarding against colorectal cancer.
Meningoencephalitis Due to Pathogenic Free-Living Amoebae
Authors: Joseph H. Callicott
Journal: JAMA (1968)

During a four-month summer period, 390 cerebrospinalfluid specimens from 357 patients were studied for the presence of a free-living amoebae.<i>Naegleria gruberi</i>was cultured from one patient with lethal meningoencephalitis.<i>Acanthamoeba astronyxis</i>was cultured from another patient with nonlethal meningitis. The latter represents, to our knowledge, the first case of nonlethal meningitis caused by the free-living amoebae. Fresh water was implicated again as a possible epidemiologic source. In any purulent meningitis in which bacteria cannot be demonstrated, amoebae should be looked for in the cerebrospinal fluid.
Endoscopy International Open – recently published
Journal: Endoscopy (2015)

See also: Proton radiotherapy dose perturbations caused by esophageal stents of varying material composition are negligible in an experimental modelEndosc Int Open 2015; 03(01): E46-E50DOI: 10.1055/s-0034-1390709 See also: 25-gauge histology needle versus 22-gauge cytology needle in endoscopic ultrasonography-guided sampling of pancreatic lesions and lymphadenopathyEndosc Int Open 2015; 03(01): E63-E68DOI: 10.1055/s-0034-1390889 See also: Efficacy of short period, low dose oral prednisolone for the prevention of stricture after circumferential endoscopic submucosal dissection (ESD) for esophageal cancerEndosc Int Open 2015; 03(02): E113-E117DOI: 10.1055/s-0034-1390797
Effect of Probiotics in Allergic Diseases
Journal: Allergy (2013)

Introduction: Familial Mediterranean Fever (FMF) is an autosomal recessive single-gene disorder that causes recurrent attacks of fever and inflammation of serosal membranes, leading to a marked acute phase response in immune cells.Aim: This descriptive study was carried out to determine the prevalence of familial Mediterranean fever, one of the single gene diseases, in Kastamonu province.Material and Methods: The population of the study consisted of 600 patients who were followed up with the diagnosis of Familial Mediterranean Fever registered in Kastamonu State Hospital as a result of a retrospective examination, and the sample consisted of 110 patients who met the inclusion criteria and accepted to participate in the study.Data were collected between January 2018 and March 2019.Results: It was found that 60.9% of
Highlights of This Issue
Journal: Clinical Cancer Research (2012)

Malignant peripheral nerve sheath tumors (MPNST) are therapy-resistant aggressive sarcomas that are frequently found in patients with neurofibromatosis. Using a combined gene expression database of mouse and human neurofibromas and MPNSTs and a Bayesian factor regression model analysis driven by a Ras-induced gene expression signature, Patel and colleagues identified overexpression and amplification of Aurora kinases in MPNSTs. The functional significance of Aurora kinase overexpression in MPNST was verified in vitro and in vivo with Aurora kinase short hairpin RNAs and compounds that inhibit Aurora kinase. Thus, transcriptome analyses, coupled with preclinical testing, identified candidates for molecular-targeted therapeutics, and blocking Aurora kinases may be a viable treatment platform for MPNST.Despite new therapeutics being tried in the clinic, multiple myeloma still remains incurable. To explore oncolytic viruses as therapeutic agents for multiple myeloma, Thirukkumaran and colleagues tested reovirus multiple myeloma oncolysis in vitro, ex vivo, and in vivo and observed its effects on human hematopoietic stem cell repopulation/differentiation in a murine model. Reovirus showed significant oncolytic activity as monotherapy against the majority of multiple myeloma cell lines, including bortezomib-resistant cell lines, ex vivo tumor, and in vivo disseminated disease and did not affect the hematopoietic stem cell compartment. This study highlights the potential for reovirus as a novel therapy for multiple myeloma.Aberrant Notch signaling is implicated in breast cancer disease progression. PF-03084014 is a small-molecule γ-secretase inhibitor that blocks pan-Notch signaling. Zhang and colleagues characterized the diverse biologic properties of PF-03084014 and evaluated the biomarkers in a panel of breast xenograft models. PF-03084014 showed significant antitumor efficacy in a subset of tested models through a pleiotropic mechanism. The Notch pathway target gene expressions were correlated with the antitumor efficacy of PF-03084014 and can potentially serve as biomarkers for both proof of mechanism and patient enrichment. This work provides guidance for the clinical investigation of PF-03084014 therapy in breast cancer patients.Paclitaxel-induced sensory peripheral neuropathy can be dose limiting and may affect a patient's quality of life. To identify biomarkers for the prediction of paclitaxel-induced peripheral neuropathy, Baldwin and colleagues performed a genome-wide association study of women receiving single-agent paclitaxel as adjuvant therapy for breast cancer. Several novel genetic loci were associated with the onset and severity of peripheral neuropathy, including a common variant in FGD4, a causal gene for the congenital peripheral neuropathy Charcot-Marie-Tooth disease. These genetic markers show promise as predictors of increased risk of paclitaxel-induced sensory neuropathy and may guide the selection and use of this important chemotherapy drug.
Surf's Up for Health Fraud Investigators
Authors: Andrew A. Skolnick
Journal: JAMA (1997)

ON NOVEMBER 5, the Federal Trade Commission (FTC) announced the results of the North American Health Claims Surf Day. In just a few hours of surfing the Internet on September 29 and 30, representatives of government agencies, health care organizations, and consumer protection groups from Canada, Mexico, and the United States netted more than 400 World Wide Web sites and numerous Usenet newsgroups that contain promotions of health products or services with dubious claims, the FTC reported. The purpose of FTC's Health Claims Surf Day was to identify potentially false or deceptive advertising claims for products or services purported to help cure, treat, or prevent 6 diseases: AIDS, arthritis, cancer, diabetes, heart disease, and multiple sclerosis. "In the few hours we surfed the Internet, we found numerous Web sites promoting a wide variety of unproven 'cures' for arthritis," said Doyt Conn, MD, senior vice president, medical affairs, for the Arthritis
Serums, Vaccines and Toxins in Treatment and Diagnosis.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COUNCIL ON FOODS AND NUTRITION
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Risk Factors in Head and Neck Cancer
Authors: John Decker, Jerome C. Goldstein
Journal: New England Journal of Medicine (1982)

THE National Cancer Institute estimates that 51,000 new cases of head and neck cancer will occur in 1982 and will result in 16,000 deaths. These cases will include 26,600 cancers of the buccal cavity and oropharynx (9150 deaths), 10,700 cancers of the larynx (3700 deaths), 9900 thyroid cancers (1050 deaths), and 3800 cancers of the nose, paranasal sinuses, nasopharynx, and cervical esophagus (2100 deaths). As a group, these tumors account for about 5 per cent of all cancers in the United States. In other parts of the world, the percentages are higher. For example, head and neck cancers in Bombay, . . .
Increased Detections and Severe Neonatal Disease Associated With Coxsackievirus B1 Infection—United States, 2007
Journal: JAMA (2008)

Enteroviruses generally cause mild disease; however, neonates are at higher risk for severe illness because of the immaturity of their immune systems. Neonatal systemic enterovirus disease, characterized by multiorgan involvement, is among the most serious, potentially fatal conditions associated with enterovirus infection. Typical clinical presentations include encephalomyocarditis (characteristic of group B coxsackieviruses) and hemorrhage-hepatitis syndrome (typical of echovirus 11). To describe the severity of neonatal illness associated with coxsackievirus B1 (CVB1) infection, CDC analyzed case reports and preliminary data from the National Enterovirus Surveillance System (NESS) for 2007. This report describes the results of that analysis, which indicated that, in 2007, CVB1 for the first time was the predominant enterovirus in the United States, accounting for 113 (25%) of 444 enterovirus infections with known serotypes. In addition, phylogenetic analysis of the 2007 CVB1 strains suggested that the cases resulted from widespread circulation of a single genetic lineage. Health-care providers and public health departments should be vigilant to the possibility of neonatal disease caused by CVB1. Testing for enteroviruses in clinically compatible cases and reporting of identified enteroviruses to NESS should be encouraged.