tbuckley/cabot-search huggingface dataset:
Abstract 2122: Head-to-head Comparison Between Tissue Doppler Imaging And Velocity Encoded Magnetic Resonance Imaging For The Measurement Of Myocardial Velocities And The Assessment Of Left Ventricular Dyssynchrony And Diastolic Function.
Authors: Nina Ajmone Marsan, Jos Westenberg, Claudia Ypenburg, Eduard R Holman, Ernst E van der Wall, Martin J Schalij, Jos Roelandt, Jeroen J Bax
Journal: Circulation (2007)

Aim of the study. To compare echocardiographic tissue Doppler imaging (TDI) and velocity encoded (VE) magnetic resonance imaging (MRI) for the measurement of myocardial velocities and the assessment of left ventricular (LV) dyssynchrony and diastolic function. Methods. Ten healthy volounteers (5 men, 31±5 yrs) and 25 heart failure (HF) pts (17 men, 58±11 yrs) underwent both cardiac MRI and TDI. Longitudinal myocardial peak systolic (PSV) and diastolic (PDV) velocities and time to PSV (Ts) and to PDV (Td) were measured at basal and mid level of LV septum and lateral wall. To quantify LV dyssynchrony, delay in Ts between basal septum and lateral wall was calculated (SLD) and pts were categorized in 3 groups according to the extent of LV dyssynchrony by TDI: minimal (SLD&lt;30 ms), intermediate (30 – 60 ms) and extensive (&gt;60 ms) LV dyssynchrony. As a measure of LV diastolic function, the ratio of transmitral E wave velocity and mitral annulus septal early velocity (E/E′) was also calculated and pts were classified in 3 groups: normal LV diastolic function (E/E′ &lt;8), abnormal LV diastolic function (E/E′= 8 –15) and severe LV diastolic dysfunction (E/E′&gt;15). Results. PSV measured with VE-MRI showed excellent correlation with PSV measured with TDI (r=0.94, P&lt;0.001) in both normals and HF pts and Bland-Altman analysis revealed a small bias (MRI-TDI) of 1±1 cm/s (P&lt; 0.001) between both techniques. A strong correlation was also observed between Ts measured with TDI and VE-MRI (r=0.97, P&lt;0.001) without significant bias. Excellent agreement between TDI and VE-MRI was found for LV dyssynchrony classification with a weighted κ=0.96. e′ and A′ PDV measured with VE-MRI correlated very well with PDV measured with TDI (r=0.95, P&lt;0.001) with a small bias of 0.4±1 cm/s (P&lt;0.001) between the 2 techniques. Excellent agreement between TDI and VE-MRI was also observed in classifying LV diastolic function with a weighted k=0.91. A very good correlation has been observed also for Td of E′(r=0.96, P&lt;0.001) and Td of A′ (r=0.88, P&lt;0.001) measured with both techniques. Conclusions. TDI and VE-MRI can be used interchangeably to measure LV myocardial systolic and diastolic velocities and excellent agreement exists between the 2 techniques for LV dyssynchrony and diastolic function classification.
Giving up on medicine:...well taken
Journal: BMJ (1993)

doing, it is relatively well paid (just compare your pay cheque with that of a non-clinical scientist).And what about when the children grow up?If she has the choice she should not give up the right to individuality, which is the right to be seen by society as a person in her own right and not simply as someone's mother or wife.I think that many of the writer's problems are philosophical in that she has realised her powerlessness in the face of disease and poverty.But she must not allow the fact that she is only one in six billion to depress her: it is the human condition.Nor should she sink into cynicism.There is a job to be done, and she can work to the good of society, in addition to earning a good salary.My message is: remember, women have struggled for centuries to have lives of their own and to be defined in terms of their own achieve- ments, not someone else's.Go and see your postgraduate dean, and anyone else you can think of, for some career advice.
Lectures to General Practitioners on the Diseases of the Stomach and Intestines. With an Account of Their Relations to Other Diseases and of the Most Recent Methods Applicable to the Diagnosis and Treatment of Them in General; also "The Gastrointestinal Clinic," in which All Such Diseases are Separately Considered.
Journal: JAMA (1904)

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Homologous Transplantation of Canine Lungs
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Confidence intervals and sample sizes.
Journal: BMJ (1991)

60 Multisvstem failure following aortobifemoral grafts for peripheral vascular disease 2 F 53 Chronic rhcumatic aortic and mitral valve disease; acute renal failure due to vasculitic-type glomerulonephritis 3 MN1 74 Panlobularemphvsemaandpostmortem ecvidece of l-antitrvpsin deficiency
The British Medical Association and its Journal.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Strychnine Poisoning
Authors: J. D. P. Graham
Journal: BMJ (1956)

<h3>Abstract</h3> Although the mitogen-activated protein kinases (MAPK) pathway is hyperactive in head and neck cancer (HNC), inhibition of MEK1/2 in HNC patients has not shown clinically meaningful activity. Using pre-clinical HNC models, we demonstrated that treatment with the MEK1/2 blocker trametinib delays HNC initiation and progression by reducing tumor cell proliferation and enhancing the anti-tumor immunity of CD8<sup>+</sup> T cells. Further activation of CD8<sup>+</sup> T cells by supplementation with anti-programmed death-1 (αPD-1) antibody eliminated tumors and induced an immune memory in the cured mice. Mechanistically, an early response to trametinib treatment sensitized tumors to αPD-1-supplementation by attenuating the expression of tumor-derived colony-stimulating factor-1 (CSF-1), which reduced the abundance of two CSF-1R<sup>+</sup>CD11c<sup>+</sup> myeloid-derived suppressor cell (MDSC) populations in the tumor microenvironment (TME). In contrast, prolonged treatment with trametinib abolished the anti-tumor activity of αPD-1, because tumor cells undergoing the epithelial to mesenchymal transition (EMT) in response to trametinib restored CSF-1 expression and re-created an immune-suppressive TME. These findings provide the rationale for testing the trametinib/αPD-1 combination in HNC and highlight the importance of sensitizing tumors to immunotherapies by using targeted therapies to interfere with the host-tumor interaction.
Health Bills Pending in Congress
Authors: Franz Goldmann
Journal: New England Journal of Medicine (1946)

ON November 19, 1945, President Truman sent a message to Congress requesting legislation for adoption of a national health program. In it, he stated: "We should resolve now that the health of this Nation is a national concern; that financial barriers in the way of attaining health should be removed; that the health of all its citizens deserves the help of all the Nation."To meet present problems the President1 recommended the adoption by Congress of "a comprehensive and modern health program for the Nation, consisting of five major parts, each of which contributes to all the others." The proposals . . .
BACTERIA AND THE TELEPHONE
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Letting Go
Authors: Max Burger
Journal: JAMA (1990)

Richard Lark was 50 years old and huge. Perhaps 350 pounds. Our scales would not register over 300. "I've lost over 50 pounds," he began stoically. "My asthma is flaring again," he wheezed, "and my sugar is out of control." He pulled up his pants leg, and his daughter unwrapped an area of redness with an ulcer at its center on the lower border of the tibia. "I've been trying to keep it clean," she said, "but it just won't heal, and I'm afraid it's going to break down even further." She was a student nurse and was taking excellent care of him. His blood pressure was well controlled. His heart failure was stable. She checked the dosages of his heart, blood pressure, asthma, depression, and eye medications. She gave him his insulin. Every day she cleansed the ulcer on his leg, took his blood pressure, and read his blood
Asthma variability
Authors: D.A. Stempel
Journal: European Respiratory Journal (2003)

Efficacy of acupuncture in asthmaTo the Editor:I read with interest the recent meta-analysis by MARTIN et al. [1], finding little evidence for an effect of acupuncture as a treatment for asthma, but was not surprised by the result.I spent my 6-week medical student elective in 1988 at the ("Western"-style medicine) Guangzhou Institute of Respiratory Diseases, Guangzhou, China.As part of the elective I reviewed, with the help of the clinic doctors, any treatments currently being used by 58 of 66 asthmatic patients attending the weekly respiratory clinic.While all except a first-time patient were taking Western treatments prescribed at the clinic, 50 (86%) had seen a traditional Chinese medical doctor for their asthma and 32 (55%) were currently using Chinese herbs.Lists of herbs being used were provided by 17 patients and 15 of these included ma huang (herba ephedra), the plant from which ephedrine was first isolated.However, only 18 (31%) patients had ever tried acupuncture for their asthma, five of whom volunteered that acupuncture had little effect.Four of the patients had had acupuncture on one of the san fu tian, the three hottest days of the year according to the lunar calendar, to reinforce the body9s yang to protect against winter asthma in the yin time of year.I was also told that in some areas, injection with dead tubercle into acupuncture points was used as a treatment for patients with intrinsic asthma.This is interesting in view of the recent discussion relating to the role of bacilli Calmette-Gue ´rin vaccination and mycobacteria in relation to allergic disease development [2].Asthmatic patients choosing to attend a Western-style hospital may have been a selected group not responding to acupuncture.However, doctors at the Guangzhou Traditional Chinese Medical College, which I also visited during my elective, held the opinion that acupuncture was not the treatment of choice for asthma as it was not particularly effective.MARTIN et al.[1] conclude from their meta-analysis that a full-scale randomised clinical trial is needed, but my experiences lead me to suggest that some prior qualitative work with Chinese medical practitioners treating asthmatic patients is needed to define the parameters of such a study, if one is in fact needed.
Resident Forum
Authors: Sandy Robertson
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spread of pertussis by hospital staff
Authors: T. L. Kurt
Journal: JAMA (1972)

Two separate outbreaks of pertussis occurred within a three-month period on the pediatric units at the University of Colorado Medical Center. Secondary cases developed among adult members of the hospital staff, as well as among pediatric patients. While most adults were only mildly ill, two adults were seriously incapacitated. Pertussis agglutination titers were performed on sera from 341 adults. Results emphasize the susceptibility of adults to pertussis, and suggest that exposure to pertussis is high among pediatric house officers, medical students, and pediatric nurses as compared to the general population. In individual cases, difficulty may be experienced making a firm diagnosis of pertussis with available techniques. This contributed to the late identification of the outbreak, and emphasizes the need for improved reporting systems in hospitals.
Cancer gene therapy using a survivin mutant adenovirus
Authors: Mehdi Mesri, Nathan R. Wall, Jia Li, Richard W. Kim, Dario C. Altieri
Journal: Journal of Clinical Investigation (2001)

We have constructed a replication-deficient adenovirus encoding a nonphosphorylatable Thr34→Ala mutant of the apoptosis inhibitor survivin (pAd-T34A) to target tumor cell viability in vitro and in vivo. Infection with pAd-T34A caused spontaneous apoptosis in cell lines of breast, cervical, prostate, lung, and colorectal cancer. In contrast, pAd-T34A did not affect cell viability of proliferating normal human cells, including fibroblasts, endothelium, or smooth muscle cells. Infection of tumor cells with pAd-T34A resulted in cytochrome c release from mitochondria, cleavage of approximately 46-kDa upstream caspase-9, processing of caspase-3 to the active subunits of approximately 17 and 19 kDa, and increased caspase-3 catalytic activity. When compared with chemotherapeutic regimens, pAd-T34A was as effective as taxol and considerably more effective than adriamycin in induction of tumor cell apoptosis and enhanced taxol-induced cell death. In three xenograft breast cancer models in immunodeficient mice, pAd-T34A suppressed de novo tumor formation, inhibited by approximately 40% the growth of established tumors, and reduced intraperitoneal tumor dissemination. Tumors injected with pAd-T34A exhibited loss of proliferating cells and massive apoptosis by in situ internucleosomal DNA fragmentation. These data suggest that adenoviral targeting of the survivin pathway may provide a novel approach for selective cancer gene therapy.
Estrogen trial for patients with endometrial cancer
Authors: A. A. Skolnick
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 814: Involvement of unique endosomes in the Mieap-induced vacuoles formation during Mieap-mediated cancer cell death
Authors: Naoki Ikari, Yasuyuki Nakamura, Hirofumi Arakawa
Journal: Cancer Research (2019)

Abstract Background: Mitochondria-eating protein (Mieap), a p53-inducible protein is known to have tumor suppressive functions by repairing or degrading unhealthy mitochondria. When Mieap degrades mitochondria, Mieap-induced vacuoles (MIVs) are formed to eat mitochondria, which subsequently induce iron-dependent cell death. Previously, we elucidated that the MIVs contain lysosomal proteins and degraded mitochondria, suggesting the MIVs represent non-canonical mitophagy. However, the process of MIV formation is still unclear. Methods: The process of MIV formation was visualized by high spatial and temporal resolution confocal live cell imaging with the EGFP-tagged Mieap protein (EGFP-Mieap) that was ectopically expressed in A549 cells. To interpret the imaging data, we performed the Mieap-interactome analysis, and consulted the list of proteins immunoprecipitated by anti-Mieap antibody. Further, we investigated the mechanism for MIV formation using various deletion-mutant forms of EGFP-Mieap. Results: The enforced expression of EGFP-Mieap generated characteristic endosomes whose membrane contained Mieap. The unique endosomes showed directed movement toward clusters of mitochondria, where MIVs were generated, and enlarged by eating mitochondria and fusing to each other. When we reviewed the list of Mieap-interacting proteins considering the directed movement, alpha tubulins were found to be included. The endosomes consisting of C-terminus deficient Mieap showed nondirected movement and accumulated at the edge of the cells. Conclusions: Besides lysosomes and mitochondria, MIVs are derived from the Mieap-related endosomes via the endocytosis/pinocytosis. Possibly, the interaction between the C-terminus region of Mieap and alpha tubulins is critical for the endosome delivery to the mitochondria in MIV formation. Citation Format: Naoki Ikari, Yasuyuki Nakamura, Hirofumi Arakawa. Involvement of unique endosomes in the Mieap-induced vacuoles formation during Mieap-mediated cancer cell death [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 814.
PRAGTIGAL NOTES.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errata
Authors: J Hainsworth, R Herbst, T Mok, S Leong, X Liu, Y Ichinose, V Sriuranpong, C Liam, Y Chen, E Duffield, Y Rukazenkov, M Fukuoka, Astrazeneca Roche, ; Pfizer, Eli Lilly, ; Leong, ; Liu, Y Liam, Astrazeneca Chen, M Reck, J Von Pawel, P Zatlouka, R Ramlau, V Gorbounova, V Hirsh, N Leighl, J Mezger, V Archer, C Manegold 10
Journal: Journal of Thoracic Oncology (2008)