tbuckley/cabot-search huggingface dataset:
Effects of Inhibitors of Glycolysis on Intracellular &lt;italic&gt;p&lt;/italic&gt;H and on Accumulation of Glycolytic Intermediates in the Ehrlich Ascites Tumor Cell&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Doris T. Poole, Thomas C. Butler
Journal: JNCI Journal of the National Cancer Institute (1969)

Ehrlich ascites tumor cells were incubated aerobically in a Krebs-Ringer phosphate buffer. The glycolytic intermediates, glucose-6-phosphate, fructose-6-phosphate, fructose-1,6-diphosphate, dihydroxyacetone phosphate, glyceraldehyde phosphate, and glycerol-1 -phosphate, were measured, and intracellular pH was calculated from the distribution between intracellular and extracellular water of the weak acid, 5,5-dimethyl-2,4-oxazolidinedione. When glucose was added to cells incubated with 0.2 mM iodoacetate, lactate production was completely blocked. Incubation with 40 mM oxamate partially inhibited lactate production. Both these inhibitors caused the accumulation of phosphorylated intermediates, principally dihydroxyacetone phosphate. Intracellular pH fell almost to as great an extent when glucose was added in the presence of these inhibitors as when it was added in their absence. When 2-deoxy-D-arabino-hexose (2-deoxyglucose) was added to the cells, there were accumulation of 2-deoxyglucose-6-phosphate and a fall of intracellular pH. When 2-deoxyglucose was added after incubation with glucosone, there were no phosphorylation of 2-deoxyglucose and no fall of intracellular pH. It is concluded that the accumulation of phosphorylated intermediates accounts for intracellular acidification when lactate production is inhibited.
A High-Tumor-Incidence Subline of the D1 Mouse Mammary Hyperplastic Outgrowth Line: Effect of Carcinogens&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn3"&gt;3&lt;/xref&gt;
Authors: Rhoda L. Ashley, Robert D. Cardiff
 6, Terry S. Pratt, Leslie J. Faulkin
Journal: JNCI Journal of the National Cancer Institute (1982)

Mammary tumorigenesis in some mouse strains is characterized by the appearance of a preneoplastic lesion, the hyperplastic alveolar nodule (HAN). The biology of the HAN has been characterized primarily through the study of stable outgrowth lines of serially transplanted HAN. One outgrowth line, Dl, which was developed and carried in female BALB/c mice, has been described as a low-tumor-incidence line that does not express murine mammary tumor virus (MuMTV) and is susceptible to hormonal, chemical, and viral carcinogens. In this report, a high-tumor-incidence subline of Dl, Dl/UCD, is described. Although Dl/UCD, like Dl, is susceptible to the chemical carcinogen 7,12-dimethylbenz[a]anthracene, an increase in tumor incidence was not observed when Dl/UCD outgrowth was exposed to hormones by means of pituitary isografts. Unlike Dl, Dl/UCD is refractory to the carcinogenic action of MuMTV. Both Dl and the Dl/UCD subline contained the endogenous MuMTV provirus but did not contain exogenous MuMTV provirus sequences. MuMTV antigen was not detected in Dl/UCD outgrowths or tumors. RNA hybridizable to MuMTV complementary DNA was detected in some Dl/UCD outgrowths and tumors but did not appear to correlate with tumorigenesis.
THE SIGNIFICANCE OF URINARY AMMONIA
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Temporomandibular Joint
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Auer Bodies In Mature Neutrophils
Authors: A. Robert Davies
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Auer bodies are rod-shaped inclusions formed from azurophilic granules.<sup>1</sup>These structures have long been recognized in the blast cells of certain patients with leukemia and their presence is considered to be strongly suggestive, if not diagnostic, of acute myeloblastic or monoblastic leukemia.<sup>2-4</sup>Many reports have appeared clarifying the origin,<sup>1</sup>occurrence,<sup>5-8</sup>significance, composition,<sup>9-11</sup>and ultrastructure,<sup>12</sup>of these rods. A review of the literature, however, discloses only two references<sup>9,13</sup>regarding the appearance of Auer bodies in mature polymorphonuclear leukocytes. We have observed these cytoplasmic inclusions not only in the young leukemic cells but in morphologically mature neutrophilic polymorphonuclear leukocytes as well. To our knowledge this curiosity has not been previously photographed. <h3>Report of a Case:—</h3> The patient was a 41-year-old salesman who entered the Veterans Administration Hospital complaining of weakness of six weeks' duration. Physical examination revealed generalized pallor and several ecchymoses
Gc Group Distributions in Patients With Cancer
Journal: JNCI Journal of the National Cancer Institute (1968)

The distribution of the serum group-specific, Gc components in 762 patients with different types of cancer was compared with that in 401 healthy adults. Patients with breast carcinoma and malignant melanoma did not differ from individuals in the normal population, whereas in the remaining cancer patients a significant increase in the frequency of the Gc 2: 2 phenotype was observed. This increase occurred in patients with cancers of different germ-layer origin and involved female rather more than male patients. In certain female cancer patients there were also fewer heterozygotes, with phenotype distributions that were not in agreement with Hardy-Weinberg proportions.
Time-Dependent Changes in Drug Sensitivity Expressed by Mammalian Cells After Exposure to Trypsin<xref ref-type="fn" rid="FN2">2</xref>
Authors: S. C. Barranco, W. E. Bolton, J. K. Novak
Journal: JNCI Journal of the National Cancer Institute (1980)

Immediately after a 5-minute exposure to 0.025% trypsin, Chinese hamster ovary cells treated with anticancer drugs exhibited changes in drug sensitivity. Depending on the drug, cells immediately became more sensitive, less sensitive, or showed no change in sensitivity at all. The deviation from normally expected survival values ranged from fourfold to fifty-fold and varied with time (of drug treatment) after trypsinizatlon. By the 12th hour post trypsinization, the drug survival responses had returned to values obtained with untrypsinized cells.
The Summary or Abstract
Authors: Charles G. Roland
Journal: JAMA (1968)

There is no intrinsic difference between a well-prepared summary and an abstract. Indeed, the<i>Oxford English Dictionary</i>defines<i>abstract as</i>"a summary or epitome of a statement or document," and a<i>summary</i>of a statement is one "containing or comprising the chief points or the sum and substance of a matter." Thus if an editor asks you to prepare a summary, or an abstract, or a synopsis-abstract, you should in each case arrive at the same product. Of course, the abstract and the summary have different uses. Separate publication of abstracts provides a means of rapidly distributing information to large audiences, and this type of publication has become increasingly popular and important in the past 20 years. Although abstracting services often write abstracts, it is probably better to have the author do so himself. During the past decade more and more journals have adopted the practice of publishing a summary
Forcible Administration of Antipsychotic Medication
Authors: Henry R. Arkin
Journal: JAMA (1983)

ONE OF the most controversial issues in psychiatry today is whether involuntarily confined patients in state mental institutions have a right to refuse treatment with powerful antipsychotic drugs. Because of recent court decisions, this is now an immediate concern for psychiatrists and mental institutions. The issue involves a number of legal and medical questions. Should informed consent apply in mental institutions? Must the state provide treatment? Should the state act contrary to the wishes of a patient or guardian when professional opinion disagrees with the patient? May the state forcibly medicate a patient in an emergency? From a medical perspective, antipsychotic drugs, also referred to as psychotropic drugs, are widely accepted and are commonly used in mental institutions. Proponents consider them an effective treatment for psychotic patients. Critics dispute their effectiveness and claim that they are used primarily to control behavior, especially in crowded, understaffed facilities. There is no disagreement
Time for New Head, New Approach at OAM
Authors: Charles Marwick
Journal: JAMA (1994)

WHEN Joseph J. Jacobs, MD, MBA, announced that he was resigning as director of the National Institute of Health's (NIH) Office of Alternative Medicine (OAM) this past summer, his decision was widely viewed as a setback in the effort to evaluate unconventional medical practices. But in another light, it is also an opportunity for the proponents of so-called alternative medicine to take a serious look at the office's program and to lay out a realistic and productive plan to achieve the goals all the parties say they want. Whether this will happen depends on the resolution of a number of disparate opinions about the whole approach to evaluating unconventional therapies, the specific priorities to be selected from a broad variety of treatments, and, perhaps most important, the development of a spirit of trust among the parties involved and a willingness by alternative medicine's sponsors to deal with the realities of
Hand-Foot-and-Mouth Disease
Authors: George D. Miller
Journal: JAMA (1968)

A vesicular exanthem with a characteristic oral-hand-foot pattern has been reported with some frequency in the last few years, and enteroviruses of Coxsackie group A have been implicated. Type A16 is most common, but A5 and A9 have been reported occasionally. The entity associated with type A16 was apparently widespread in the summer and fall of 1966. The course is usually benign but serious complications have been reported in the literature. Although children are most often infected, this series reports only one child out of a total of 11 patients studied. This viral syndrome is not to be confused with "hoof and mouth disease," a rarity in humans and not caused by a coxsackievirus.
Longitudinal analysis of the quality of life (QoL) within a randomized phase III trial: Octreotide versus placebo for the patients having advanced hepato-cellular carcinoma (HCC)
Authors: F. Dumas, J. Barbare, T. Aparicio, O. Bouché, C. Lombard-Bohas, R. Faroux, J. Seitz, J. Raoul, L. Bedenne, F. Bonnetain
Journal: Journal of Clinical Oncology (2009)

e20537 Background: The primary objective of this ancillary study is to longitudinally compare QoL. Secondary objective was to explore definitions of time until definitive deterioration (TUDD) of QoL scores according to minimal clinically important difference cut off (MCID). Methods: Inclusion criteria were age &gt; 18 years, diagnosis of HCC with CLIP 0 - 3 and to be ineligible for curative treatments. Patients (pts) were randomized 1:1 to receive octreotide (30 mg, every 4 weeks for 2 years or until death) or placebo (2 mL NaCl). QoL was evaluated using EORTC QLQ-C30 every 4 weeks up to 24 months. We focused analyses on the following scores: Global Health (GH), Mental Health (EF), Physical Health (PF) and Pain (P). Firstly mean differences of QoL scores between last available measurement and inclusion were compared using Wilcoxon test. Secondly TUDD were estimated using Kaplan Meier, and compared using log-rank tests. They were defined as the time interval between randomization and the first occurrence of a decrease in QLQ-C30 score of ≥ 5 points without any further improvement in QoL score of ≥ 5 points or any further available QoL data. These analyses were repeated using a 10 points MCID, and by including deaths as event. Results: Between July 2002 and October 2003 135 pts in octreotide and 137 pts in placebo arm were included. Mean differences of QoL did not differed between octreotide and placebo arm. Using a 5 points MCID, TUDD of GH score is significantly longer in the placebo group (stratified log rank p= 0.033); median was 2.3 (95% CI: 1.37–3.66) vs 4 months(2.23–5.7). Using a 10 points MCID, TUDD of GH score differed, median time was 2.5 (1.9- 3.73) for the octreotide and 4.7 months (2.73 - 5.8) for the placebo group (stratified log rank p=0.026). Including death as event for a 10 points MCID, median was 2.4 (1.83–3.17) for octreotide and 4.1 months (2.5–5) for placebo group (stratified log rank p=0.012). Conclusions: These results suggest that octreotide could have a negative effect on global QoL. We have investigated QoL analyses modalities using survival techniques dealing with binding drop out missing data and with an easier clinical interpretation of results. No significant financial relationships to disclose.
Polycystic Disease of the Liver
Authors: Stuart Z. Lanson
Journal: JAMA (1971)

Polycystic liver disease usually presents as a benign progressive hepatomegaly, the true characteristic of which is found during surgical exploration or at postmortem examination. Liver function tests, biopsies, and scans are of little value diagnostically. Preoperative use of a percutaneous cystogram is diagnostic and safe, provided parasitic disease has been ruled out. Areas where partial or complete lobectomy might be indicated are delineated preoperatively with hepatic angiography. Surgical peritoneal marsupialization provides effective relief.
Gastric "Time Bomb"
Authors: Robert J. Cihak
Journal: JAMA (1969)

Dr. David A. Kumpe: This young man had been mentally depressed several times, before being admitted with reactive depression to another hospital. He had attempted suicide by swallowing "two double-handfuls" of glucose-test (Clinitest) tablets for urine. About forty minutes later he vomited, and gastric lavage was performed. He then attempted suicide again by jumping from a window, fell three stories and sustained a fracture of the third lumbar vertebral body. Gastric hemorrhage and intestinal ileus ensued which were treated with 1,000 cc whole-blood transfusion and nasogastric suction. Seven days after these suicide attempts, he was transferred to the Massachusetts General Hospital. On auscultation, moist rales were heard at the left lung base. There was moderate tenderness over the midlumbar region of the spine, but the results of physical examination were otherwise unremarkable. Reaction of the guaiac test on the stool was 2+. Temperature was 101.2 F (38.4 C, but vital
The Illness Narratives: Suffering, Healing and the Human Condition.
Journal: Annals of Internal Medicine (1991)

De acordo com o prefácio, no início dos anos 60, quando Arthur Kleinman (médico psiquiatra com treinamento em antropologia) estava no segundo e terceiro anos da escola de Medicina, encontrou vários pacientes, cujas experiências de doença fixaram seu interesse em como a doença afeta a vida das pessoas.Nas duas décadas passadas, o autor interessou-se pelas doenças crônicas, vindo a realizar estudos clínicos e etnográficos sobre a experiência da doença entre pacientes da China e dos EUA.A própria experiência de Kleinman como doente crônico (asmático) e os cuidados recebidos de dois clínicos são abordados neste livro, enriquecendo seu conteúdo.Diferentemente de outros livros escritos pelo mesmo autor -dirigidos sempre a profissionais da área -este foi destinado a pacientes e suas famílias.Assim, o autor quis popularizar a literatura técnica, que deverá ser de valor para aqueles que lidam com doentes crônicos.De fato, o autor sustenta que o estudo da experiência tem algo de fundamental a ensinar-nos acerca da condição humana.Nada concentra tanta experiência e clarifica aspectos centrais da vida como uma doença grave.A doença crônica nos ensina sobre a morte, e o processo de lamentação por perdas é central para a cura.As narrativas de doença nos proporciona informação de como os problemas da vida são criados, controlados, e têm significados.Illness tem significado, e entender como se obtém esse significado é entender algo fundamental acerca da doença, do cuidado e da própria vida.Este livro é clinicamente útil para aprender como interpretar a questão da doença sob o ponto de vista do paciente e de sua família.Além disso, a interpretação das narrativas da experiência da doença é uma tarefa central no trabalho da terapêutica.A medicina moderna, burocrática, e os profissionais que a praticam estão acostumados a tratar o problema da doença como se o paciente só requeresse uma reparação técnica, sem considerar a profundidade dos significados da doença.O livro consta de 16 capítulos, sendo os dois primeiros introdutórios, onde é discutido "significado" da doença.Os seguintes detalham experiências de doenças de pacientes crônicos que foram estudados na pesquisa clínica ou tratados pelo autor.Cada capítulo realça um aspecto diferente dos significados da doença.Nos últimos três capítulos (14 ao 16), Kleinman enfatiza a relação paciente, familiares e pessoal encarregado da terapêutica.O capítulo 16 contém um guia para o cuidado dos doentes crônicos e
Thoracic Actinomycosis
Authors: P Duhra, A Ilchyshyn, R Bell
Journal: Journal of the Royal Society of Medicine (1992)

Thoracic actinomycosis is an rare disease in our medium. This fact, together with the variability of its forms of presentation and the difficulty in isolating its etiologic agent, make its diagnosis, particularly difficult.A series of 8 cases diagnosed in the years 1988, 1989 and 1990 in two centers (Hospital de Bellvitge-Prínceps d'Espanya and Hospital de l'Esperança) is described with evaluation of the clinical and analytical data and the therapy applied.Species were only identified in 3 cases with Actinomyces israelii in two and Actinomyces odontolyticus in the third. The proven association with Mycobacterium tuberculosis, the presence of distant septic metastasis and eosinophilic pleuritis as forms of presentation are of note. Medical treatment was penicillin or derivatives in all the cases except one which was treated with diagnostic/therapeutic segmentectomy.It is concluded that when any subacute involvement of the thoracic and/or pleuropulmonary wall specific cultures should be carried out to discard eventual thoracic actinomycosis.
Influenza Activity-- United States and Worldwide, April-October 2000
Journal: JAMA (2000)

During October 1999-May 2000, influenza A(H3N2), A(H1N1), and B viruses were identified in the Northern Hemisphere. Influenza A(H3N2) predominated, but the number of influenza A(H1N1) viruses increased toward the end of the influenza season in the Northern Hemisphere. Since April, influenza A viruses have predominated in the Southern Hemisphere and tropical regions, but influenza B viruses also have been identified. This report summarizes influenza activity in the United States and worldwide from April 2000 through October 2000.
Functional Endocrinology from Birth through Adolescence.
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lower-Extremity Injuries as Related to the Use of Ski Safety Bindings
Authors: Richard Spademan
Journal: JAMA (1968)

Loss of control and safety-binding failure were found to be the major causes of skiing injuries at Squaw Valley, Calif. Inadequate instruction as manifest by lack of competence, poor judgment, and over-reliance upon the functional capabilities of safety bindings was a greater contributory factor than snow or slope conditions. Consideration of the nature and distribution of injuries sustained in the lower extremity showed that the release characteristics of safety bindings do not compensate for the forces present during a fall condition.
Risks From Polio Vaccination
Authors: Max Bader
Journal: JAMA (1984)

<h3>To the Editor.—</h3> In their response to my letter on polio vaccination during pregnancy, Goodman et al<sup>1</sup>state, "Use of the number of doses distributed gives a measure of the overall risk of vaccine-associated poliomyelitis and gives a prospective OPV [oral polio vaccine] recipient or contact of a recipient the overall odds of becoming a vaccine-associated case." The courts of the state of Washington have held that this statement was inadequate and misleading and, therefore, awarded judgment to the vaccine-associated polio victim against the vaccine manufacturer. Other parties to the litigation settled out of court, in part because that statement on the signed informed consent was regarded as indefensible. The vast majority of OPV recipients are newborns who are slated to receive four doses of OPV (five in past years) by the time they enter school. Consequently, estimation of "one case of paralytic poliomyelitis in recipients or contacts for