tbuckley/cabot-search huggingface dataset:
JAMA 75 YEARS AGO
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Access Provided by Korea University Medical Library JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account
Evaluation of the role of second TUR for transurethral resection of bladder tumor in one piece (TURBO).
Authors: H. Ikeda, M. Nomura, T. Shou, K. Ishikawa, E. Kashiwagi, T. Dejima, H. Sanefuji, K. Okumura
Journal: Journal of Clinical Oncology (2011)

e15009 Background: Since transurethral resection of bladder tumor in one piece (TURBO) was reported in the Journal of Urology in 2000 by Ukai, some urologists carried out TURBO. We analyzed treatment results of TURBO in our hospital and examined the value of this procedure, especially for the pathological findings, recurrence and necessity of second TUR for TURBO. Methods: A total of 14 patients with bladder tumors carried out TURBO under spinal anesthesia, in some cases blocking the obtulater nerve, from April 2006 to June 2009 in our hospital. All cases were followed for over 1 year. The procedure is 1. point marking; 2. circular incision; 3. level incision; and 4. specimen retrieval using a needle electrode in accordance with the Ukai's method. We investigated pathological findings (margin situation), operation time, complications and recurrence. Results: It is possible to diagnose the precise pathlogical findings by TURBO. We judged the width and depth ew in sequential section. There were no complications during and after the operation. Operation time of TURBO (35-170 min) was longer than TUR-BT. Urethral catheter holding period and hospitalization period after TURBO was the same as TUR-BT. TURBO is a relatively safe procedure even for beginners. 5 cases had a recurrence in 13 cases. 2 cases had a recurrence in under 1 year, but the locations were other places. One case had a same place recurrence after 13 months. There were no cases of same place recurrence in under 1 year among margin-negative cases. Therfore we judged that ew-negative cases had no residual cancers. Conclusions: TURBO is a safe and useful procedure that provides precise pathological findings with minimal complications. Second TUR is not necessary for TURBO. TURBO has a possibility to be gold standard of the treatment for non-muscle invasive bladder cancer.
Primary type V hyperlipoproteinemia in childhood
Authors: D. Yeshurun
Journal: JAMA (1977)

Metabolic studies of a 9-year-old girl with primary type V hyperlipoproteinemia demonstrated normal glucose tolerance, plasma insulin and glucagon responses to stimuli, and serum uric acid level. Fasting plasma triglyceride levels rapidly increased when the patient received a diet containing 40% of the total calories as fat and rapidly decreased on a 10% fat diet. Hepatic and nonhepatic lipase activities in postheparin plasma were normal, thus excluding type I hyperlipoproteinemia. Because of the potential complication of acute pancreatitis in this disorder, early diagnosis and prompt institution of diet therapy is important. (<i>JAMA</i>238:2518-2520, 1977)
THE NUTRITION OF BACTERIA
Journal: JAMA (1918)

There is an enlightening frankness in the presidential address of Professor Rettger<sup>1</sup>of Yale University, before the American Society of Bacteriologists, wherein it is stated that "we are as yet in the dark regarding the real food requirements of bacteria." The widespread preaching that these lowly organisms are the scavengers that utilize practically all sorts of organic matter as food gives little indication of the rapidly growing evidence of the specific peculiarities of bacterial nutrition—of the suggestion that "the problem of dietetics in bacteriology is as real as in animal physiology." Rettger reminds us once more that the processes involved in the pancreatic digestion of protein are in a large measure reproduced by the proteolytic enzymes of organisms of the<i>Bacillus subtilis</i>and<i>Proteus vulgaris</i>types, certainly by the organisms of putrefaction. A new interpretation may be brought to the well known fact that bacterial enzymes are able to
Mortality in cases of asbestosis diagnosed by a pneumoconiosis medical panel.
Authors: J Cotes
Journal: Thorax (1987)

Mortality in cases of asbestosis diagnosed by a pneumoconiosis medical panel SIR,-The statement by Dr II Coutts and colleagues that mortality in men with asbestosis is unrelated to profusion of small opacities (February 1987;42:111-6) merits further dis- cussion.There should not have been any association in men who died of non-pulmonary conditions.For smokers who died of lung cancer some association might have been ex- pected; it was possibly weak because even mild diffuse fibrosis constitutes a material additional risk.'For men dying of respiratory insufficiency there would have been a relationship if in most instances death was due to the paren- chymal effects of asbestos.That this was not the case suggests the pleural effects were possibly of greater prognostic significance.The authors refer only to parenchymal effects and to the whole group.It would be of interest to know for the sub- group of patients with respiratory failure if the mortality was related to the combined parenchymal and pleural abnormal- ities or to the latter alone.Pleural disease can seriously im- pair lung function.23
Urokinase Study
Authors: J. G. Sharnoff
Journal: JAMA (1968)

<h3>To the Editor:—</h3> I read with great interest the news item, "National Urokinase Study Underway," (<b>205</b>, Aug 12, 1968, adv p 21). Death from pulmonary embolism has long been an often unexpected and greatly dreaded unnecessary loss of life, particularly for hospitalized patients, especially for the immobilized medical patient, but most especially for the surgical patient postoperatively and those dying of sudden cardiopulmonary arrest in the operative period.<sup>1</sup>Any new modality which may save life is a welcome addition to medical progress. This projected study from the National Heart Institute holds hope for a very small number of all thromboembolic deaths. As G. De Takats once stated so aptly, pulmonary thromboembolism causes death so rapidly in over 90% of individuals that they are "found suddenly dead in bed," offering no time to help. But not all individuals die after the first episode of pulmonary thromboembolism. Quite a few survive without
Severe Hepatotoxicity of Telithromycin
Authors: Kimberly D. Clay
Journal: Annals of Internal Medicine (2006)

Letters19 September 2006Severe Hepatotoxicity of TelithromycinKimberly D. Clay, MD, MPHKimberly D. Clay, MD, MPHFrom the Carolinas Medical Center, Charlotte, North Carolina.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-145-6-200609190-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE: In case 1, the patient started to notice dark urine on day 2 of treatment with telithromycin. When his wife noted continued symptoms on day 3, the patient decided to stop taking the medication. It was a week later, when the patient presented to his physician, that the laboratory tests were performed and abnormalities were noted.With respect to case 3, I would say that the levels of acetaminophen, salicylate, and ethylene glycol were negative, which was expected based on the history given by the patient.Kimberly D. Clay, MD, MPHCarolinas Medical CenterCharlotte, NC 28203 Author, Article, and Disclosure InformationAffiliations: From the Carolinas Medical Center, Charlotte, North Carolina.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBrief Communication: Severe Hepatotoxicity of Telithromycin: Three Case Reports and Literature Review Kimberly D. Clay , John S. Hanson , Scott D. Pope , Richard W. Rissmiller , Preston P. Purdum III , and Peter M. Banks Severe Hepatotoxicity of Telithromycin Joseph S. Bertino Metrics Cited ByControlled Trial of a 5-Day Course of Telithromycin versus Doxycycline for Treatment of Mild to Moderate Scrub TyphusCurrent awareness: Pharmacoepidemiology and drug safety 19 September 2006Volume 145, Issue 6Page: 472KeywordsConflicts of interestEthyleneLaboratory testsSalicylatesUrine ePublished: 19 September 2006 Issue Published: 19 September 2006 CopyrightCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Of Tomorrow
Authors: F. J. L. Blasingame
Journal: JAMA (1964)

THE PAST IS SPENT, and we have but fragments of it in memory and history. The future is not with us—always ahead. We possess only the vital, vivid present—the now, this moment as it passes. But we should have vision and anticipate our tomorrow. Of such are our dreams, and why not dream? Medicine has a rich past, enjoys a vigorous present, and can play a great role in tomorrow. As man cleans the cobwebs of confusion, fear, and ignorance from his mind, a sense of value of health is coming upon the scene in human affairs. Health speaks a universal language: individually to each of us and collectively to all of us. Within the short span of lives of most of us, we have witnessed a great burst of knowledge that has given power to medicine, transformed its character, and expanded its mission and its meaning. The capacity to
Practical Zoology for Medical and Junior Students.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"HAIR FOOD"
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Medical Society
Authors: John P. Ahearn
Journal: New England Journal of Medicine (1957)

COMMITTEE ON MATERNAL WELFARECardiovascular and Renal Disease, with Premature Separation of the PlacentaA thirty-six-year-old gravida 4, para 3, died eight hours after admission to the hospital for increasing cyanosis and dyspnea.Hypertension had been discovered during the first pregnancy thirteen years earlier, when the blood pressure was 170 systolic, 110 diastolic, but she had no other complications and was delivered of a 3.2-kg. (7-pound) infant. The second pregnancy was terminated by cesarean section during the ninth month, because of a rise in blood pressure to 225 systolic. There was no edema or albuminuria. In the third pregnancy four . . .
Dangerous Bronchitis
Authors: E. K. Westlake
Journal: BMJ (1955)

The importance of bronchitis as a cause of morbidity and mortality needs no emphasis: in England and Wales in 1950 590,000 spells of incapacity from work and 28,000 deaths were attributed to this cause.With few exceptions,* acute bronchitis becomes a serious illness only in patients with pre-existing impairment of respiratory function-those with chronic bronchitis, emphysema, pulmonary fibrosis, severe chest wall deformity, or heart disease.In such subjects an exacerbation of bronchitis may precipitate acute respiratory failure with generalized impairment of the ventilation of the lung alveoli.Carbon dioxide accumu- lates in underventilated alveoli, with a consequent fall in oxygen tension.The blood leaving such alveoli is not fully oxygenated and has a high carbon-dioxide tension which causes a shift of blood pH toward the acid side.This triad of carbon-dioxide retention, anoxaemia, and acidaemia-which may be demonstrated by arterfal blood analysis-characterizes respiratory failure.Pathogenesis of Respiratory Failure How does respiratory failure arise during acute chest infections ?A complete answer would require a lengthy digression into the realms of respiratory physiology, but, in brief, there are two principal causes.(1) Impaired Sensitivity of the Respiratory Centre.-Respiratory infection may initiate a vicious circle: pulmonary infecti6n--arterial anoxaemia-->anoxic damage to the medullary respiratory centre->diminished drive to the respiratory muscles -> alveolar hypoventilation .--carbon-dioxide retention--further increase in arterial anoxaemia.This sequence of events is particularly apt to occur in the chronic bronchitic or emphysematous subject who-even when free from respiratory infection-is chronically anoxic and shows a diminished respiratory response to inhalation of carbon dioxide.Treatment is based on oxygen therapy, which prevents further damage to the respiratory centre, together with the use of respiratory stimulants.(2) Increased Metabolism and Reduced Ventilatory Capacity.-Increase in metabolic rate may be due, in part, to fever, but more specifically to the greater energy
Magnetic Fields and Cancer
Authors: Thomas L. Jones
Journal: Environmental Health Perspectives (1993)

LetterOpen AccessMagnetic fields and cancer.is a letter which has replyResponse: Potential Bias in Denver Childhood Cancer Study T L Jones T L Jones Search for more papers by this author Published:1 October 1993https://doi.org/10.1289/ehp.93101368AboutSectionsPDF ToolsDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InReddit "Magnetic fields and cancer.." Environmental Health Perspectives, 101(5), pp. 368–370FiguresReferencesRelatedDetailsRelated articlesResponse: Potential Bias in Denver Childhood Cancer Study1 October 1993Environmental Health Perspectives Vol. 101, No. 5 October 1993Metrics About Article Metrics Publication History Originally published1 October 1993Published in print1 October 1993 Financial disclosuresPDF download License information EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted. Note to readers with disabilities EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact [email protected]. Our staff will work with you to assess and meet your accessibility needs within 3 working days.
Language Class
Authors: Richard Donze
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
249. cAMP and EPAC Signaling Functionally Replace OCT4 During Induced Pluripotent Stem Cell Reprogramming
Authors: Maroof M. Adil, Ashley L. Fritz, Sunnie R. Mao, David V. Schaffer
Journal: Molecular Therapy (2015)

The advent of induced pluripotent stem cells – generated via the ectopic overexpression of reprogramming factors such as OCT4, SOX2, KLF4, and C-MYC (OSKM) in a differentiated cell type – has enabled groundbreaking research efforts in regenerative medicine, disease modeling, and drug discovery. While initial studies have focused on the roles of nuclear factors, increasing evidence highlights the importance of signal transduction during reprogramming. Because signaling pathways offer numerous targets for pharmacological and genetic intervention, identifying new roles for signaling pathways in reprogramming can lead to the development of new reagents and approaches for both reprogramming and stem cell biology. By utilizing a quantitative, medium-throughput screen to initially identify signaling pathways that could potentially replace individual transcription factors during reprogramming, we initially found that several pathways – such as Notch, Smoothened, and cAMP signaling – were capable of generating alkaline phosphatase positive colonies in the absence of OCT4, the most stringently required Yamanaka factor. Furthermore, we found that activating cAMP signaling with forskolin (FK) along with the addition of GSK3β and MEK inhibitors (CHIR99021 and PD 0325901, or 2i) could replace OCT4 at relatively high efficiency, as determined by the percentage of OCT4-postitive colonies formed from cells infected with reprogramming factors (Figure 1). Additionally, investigation of downstream cAMP signaling effectors indicated that EPAC signaling pathway rather than PKA is necessary and sufficient for OCT4 replacement. We further show that a downstream effector of EPAC signaling, RAP1, is necessary during both four-factor reprogramming and OCT4 replacement. Moreover, a small molecule cAMP analog that specifically activates the EPAC pathway, 8-pCPT-2'-O-Me-cAMP, replaces OCT4 in reprogramming and generates induced pluripotent stem cells which can form the three germ layers following embryoid body differentiation in vitro and teratomas in immunodeficient mice. cAMP signaling may reduce barriers to reprogramming by contributing to downstream epithelial gene expression, decreasing mesenchymal gene expression, and increasing proliferation. Ultimately, these results elucidate mechanisms that could lead to new reprogramming methodologies and advance our understanding of stem cell biology. Moreover, the screening methodology presented here may be useful to study the importance of signaling pathways within mammalian cell biology, including pluripotency reprogramming, direct lineage reprogramming, and/or differentiation.
Oncology
Authors: Eugene M. McKelvey
Journal: JAMA (1982)

Important strides have been made in clinical oncology by identifying the basic principles underlying successful therapy and applying them more broadly. With this effort has come the realization that different malignant diseases may have their own special requirements for diagnosis and staging, the evaluation of patient prognosis, the development of optimal therapy, and the appraisal of long-term sequelae. During the past year, established methodology has been refined and new innovative approaches developed in each of these areas. <h3>Cancer Diagnosis and Staging</h3> A number of radiological procedures of established value now are generally available. Each has its own specific advantage. Computed tomography (CT) has more than justified the expense involved and is particularly valuable in evaluating brain, head and neck, gastric, and endometrial cancer, and tumors in certain pathological categories, such as liposarcomas.<sup>1</sup>In addition, more attention is now being given to the use of CT attenuation values and dynamic
The Computer and the Clinical Decision Process
Authors: MERVIN ROSENBERG, BERNARD C. GLUECK, CHARLES F. STROEBEL
Journal: American Journal of Psychiatry (1967)

Short-term results with the use of automated nursing notes at the Institute of Living indicate that there are significant gains in the day-to-day care of patients. Longterm benefits can be anticipated from the comparison and evaluation of data over time so that better observational techniques can be developed, more plausible inferences made, and treatment hypotheses refined.