tbuckley/cabot-search huggingface dataset:
The pathology of hepatitis C as a function of mode of transmission: Blood transfusion vs. intravenous drug use
Authors: S Gordon
Journal: Hepatology (1993)

We reviewed the clinical records of 140 consecutively evaluated patients with chronic hepatitis C infection. One hundred twenty-four patients (89%) contracted infection through blood transfusion or intravenous drug use. The liver biopsy specimens of 83 patients (43 blood transfusion cases and 40 intravenous drug abuse cases) were examined without knowledge of the mode of disease transmission. The mean histological activity index score was significantly higher in the blood transfusion group (10.2 ± 4.2) than in the intravenous drug use group (6.9 ± 4.5) (p = 0.001). The transfusion group had more periportal bridging necrosis (p = 0.0015) and fibrosis (p = 0.0016) than did the intravenous drug use group, whereas significant differences between lobular degeneration and portal inflammation were not achieved across the two groups. The distribution of final biopsy interpretations also differed significantly between the two groups (p < 0.001), with chronic active hepatitis more frequent in the transfusion group. Moreover, lymphoid aggregates and bile duct damage were more common in patients with chronic hepatitis due to blood transfusion. Multivariate analysis showed that the mode of viral transmission was the most powerful predictor of histological activity index score when tested against patient gender, duration of disease or age at biopsy. One year after completion of this study, 9 of 70 transfused patients and 1 of 54 intravenous drug users had died of liver disease or are awaiting liver transplantation at this writing (p = 0.03). We conclude that transfusion-acquired hepatitis C is associated with more aggressive histological inflammatory activity than hepatitis resulting from intravenous drug use. We postulate that the severity of the initial pathological lesion predicts histological disease activity. (HEPATOLOGY 1993;18:1338–1343.)
Abstract 4216: The microbiota associated to cervical and anal HPV infections in a Hispanic population
Authors: Frances Vázquez-Sánchez, Gilmary Ortiz, Ana P. Ortiz, Filipa Godoy-Vitorino
Journal: Cancer Research (2019)

Abstract Anogenital human papillomavirus (HPV) are the world’s most commonly diagnosed sexually transmitted infections and high-risk types are linked to dysplasia. Susceptibility to HPV infections is related to the microbial communities of these genital surfaces, which are interfaces between the host and environment. Microbes are a predicted cause of malignancies, revealing a tremendous potential of microbiome-related processes for cancer prevention and diagnostics. The cervix and anus share a susceptible transformation zone, characterized by a metaplastic epithelial site. In fact, in women, anal and cervical squamous intraepithelial lesions tend to occur concurrently, an observation that could be explained by the fact that anal and cervical HPV infections are strongly correlated. We hypothesized that bacterial communities may differ in the anus and cervix and may reveal populations associated to HPV infections in these two body sites. To test this hypothesis we characterized the microbiota of a cross-sectional population-based sample of Puerto Rican women (self-sampled) from the San Juan metropolitan (n=300 samples) and related them to anogenital HPV infections (HPV typing performed by PCR). The microbiota of resident cervical and anal bacterial communities was performed through sequencing of the 16S ribosomal RNA V4 region with the Illumina platform. Data was analyzed at first with QIIta, using the SILVA database as taxonomic reference, and community analyses were performed in QIIME and R. Significant differences in community structure (betadiversity) were found between cervical and anal communities (p-value = 0.001), but not according to HPV (p-value = 0.212) in any of the body sites. Indeed, overall anal communities were dominated by OTUs within Prevotella, Bacteroides and Clostridiales, while cervical samples were dominated by Lactobacillus and Bifidobacteraceae (Gardnerella). Despite the common core communities at each body site, cervical samples of HPV positive patients revealed an enrichment of Ureaplasma and Prevotella while Peptinophilus was associated with anal HPV infections. Although more analyses are needed, our data suggests cervical and anal bacteria are associated to HPV infections which could pave the way to the development of early detection methods or novel probiotics for in women living in Puerto Rico. Citation Format: Frances Vázquez-Sánchez, Gilmary Ortiz, Ana P. Ortiz, Filipa Godoy-Vitorino. The microbiota associated to cervical and anal HPV infections in a Hispanic population [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4216.
Methadyl acetate vs methadone. A double-blind study in heroin users
Authors: J. H. Jaffe
Journal: JAMA (1972)

Thirty-four long-term heroin addicts were treated with either methadone hydrochloride or methadyl acetate (<i>dl</i>-methadyl acetate, acetylmethadol) under double-blind conditions over 15 weeks. These drugs were not found to be significantly different with regard to acceptability to patients, reduction of illicit drug use, increase in legitimate employment, reduction of criminal activity, frequency of clinic attendance, and medical safety. These results suggest that the advantages of methadyl acetate, namely reduction in the frequency of clinic visits and the possibility of more effective control over administration and illegal redistribution, are not outweighed by any problems detectable under the conditions of the present study. However, in spite of these potential advantages, the unusual pharmacological actions of methadyl acetate could represent potential hazards.
Postpartum Hypothyroidism
Authors: DANIEL C. POSTELLON
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 March 1978Postpartum HypothyroidismDANIEL C. POSTELLON, M.D.DANIEL C. POSTELLON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-3-431_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I wish to suggest an alternate or contributing mechanism for the transient postpartum hypothyroidism described by Amino and co-workers in the August 1977 issue (Ann Intern Med 87:155-159, 1977). Sack, Amado, and Lunenfeld have described the changes in secretion of thyroxine in breast milk (1). The amount secreted after the first postpartum week was substantial, estimated at about one half of the daily adult production rate. The concentration of thyroxine varied from patient to patient and from day to day but gradually decreased with decreasing milk production.I assume that most of the patients with postpartum hypothyroidism...Reference1. SACKAMADOLUNENFELD JOB: Thyroxine concentration in human milk. J Clin Endocrinol Metab 45:171,1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Children's Hospital of Pittsburgh Pittsburgh, PA 15213 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1978Volume 88, Issue 3Page: 431-432KeywordsAttentionBreast milkHypothyroidismMilkThyroxine Issue Published: 1 March 1978 PDF DownloadLoading ...
Swept Away: Use of General Medical and Mental Health Services Among Veterans Displaced By Hurricane Katrina
Authors: Benjamin G. Druss, Kathy L. Henderson, Robert A. Rosenheck
Journal: American Journal of Psychiatry (2007)

Objective: This study examined national patterns of outpatient service use by veterans from regions affected by Hurricane Katrina. Methods Analyses tracked use of general medical and mental/substance use services in September and October through December 2005 in New Orleans and Biloxi-Gulfport compared to a cohort receiving care during the same months in the previous 2 years. Results: In adjusted models, veterans from New Orleans and Biloxi-Gulfport were, respectively, 73% and 41% less likely in September 2005 to use any outpatient services as were cohorts from 2003–2004. Particularly in New Orleans, the relative decline in service use was substantially greater for specialty mental health and substance use services than for general medical services. Conclusions: Although many veterans were able to obtain care after Hurricane Katrina, there was a substantial disruption in delivery of Veterans Administration services, with disproportionate declines in mental health and substance use care.
SECRETIONS ELABORATED BY THE DIENCEPHALON
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
What's new this month in BMJ Journals
Authors: Harvey Marcovitch
Journal: BMJ (2004)

Patients with irritable bowel syndrome were tested for immunoglobulin G (IgG) antibodies to 29 food antigens and then randomly assigned to a test or sham diet. Investigators and patients were blinded; symptoms were reassessed after 12 weeks. Participants who excluded foods identified by the ELISA test for IgG were more likely to improve—the number needed to treat was 2.5. A previous study had found a number needed to treat of 17 for three months' treatment with tegaserod. Gut2004;53: 1459–64. [OpenUrl][1][Abstract/FREE Full Text][2] A high intake of sulphur and sulphate was associated with relapse in 183 patients with ulcerative colitis who were followed prospectively for 12 months. Comparison of the diets of the 96 who relapsed and the … [1]: {openurl}?query=rft.jtitle%253DGut%26rft.stitle%253DGut%26rft.issn%253D0017-5749%26rft.aulast%253DAtkinson%26rft.auinit1%253DW%26rft.volume%253D53%26rft.issue%253D10%26rft.spage%253D1459%26rft.epage%253D1464%26rft.atitle%253DFood%2Belimination%2Bbased%2Bon%2BIgG%2Bantibodies%2Bin%2Birritable%2Bbowel%2Bsyndrome%253A%2Ba%2Brandomised%2Bcontrolled%2Btrial%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fgut.2003.037697%26rft_id%253Dinfo%253Apmid%252F15361495%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=gutjnl&resid=53/10/1459&atom=%2Fbmj%2F329%2F7471%2F880.atom
Hyperparathyroidism and medullary sponge kidney. A chance relationship?
Authors: D. H. Gremillion
Journal: JAMA (1977)

PATIENTS with medullary sponge kidney frequently have nephrocalcinosis, nephrolithiasis, and hypercalciuria. The cause of the augmented calcium excretion is unknown. Because of these frequent associations, there has been no impelling reason to seek other causes to explain these manifestations. Recent case reports<sup>1,2</sup>emphasize the presumably chance occurrence of hyperparathyroidism with medullary sponge kidney. The true incidence of this association is unknown. Morris<sup>3</sup>has recently suggested that hyperparathyroidism is capable of inducing a renal lesion urographically indistinguishable from medullary sponge kidney. This implies that the morbidity from medullary sponge kidney might be diminished if hyperparathyroidism could be detected and surgically treated. This report describes the fourth reported case with coexisting hyperparathyroidism and medullary sponge kidney and complements previous observations of this unusual association. <h3>Report of a Case</h3> A 38-year-old woman had passed stones or gravel at monthly intervals for about 18 years. She was found to have unexplained hypercalciuria
APACE WITH PACEMAKERS
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of Chlorhexidine in the Peritoneal Cavity
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SEA BURIAL.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Carbohydrate-deficient transferrin (CDT) evaluation in the insurance industry . Speciality Laboratories, Inc., Santa Monica, CA 90404-3900; ?LabOne, Overland Park, KS 66215; ?STC Diagnostics, Bethlehem, POA 18018-1799
Journal: Hepatology (1995)

Chronic graft-vs-host disease (GVHD) has certain similarities with autoimmune diseases and is associated with the development of various autoantibodies in some patients. In this study, we analyzed the occurrence of autoantibodies in 63 patients surviving longer than 3 months after an allogeneic haematopoietic stem cell transplantation (HSCT), with the aim of detecting a possible association between occurrence of autoantibodies and development of chronic GVHD and immune recovery after HSCT.The patients were screened every 3 months for the occurrence of the following autoantibodies: anti-nuclear (ANA), anti-mitochondrial (AMA), anti–smooth muscle (ASMA), anti-cardiolipin (ACLA), anti-liver-kidney microsomal (LKM), anti-DNA, anti-neutrophil cytoplasmatic (ANCA), and anti-thyroid antibodies. Peripheral blood immunophenotyping with anti-CD3, CD4, CD8, CD19, CD20, CD16, and CD56 antibodies was evaluated at the same intervals.Autoantibodies were not found in 18 patients (29%), at least in one screening in 29 patients (46%), and in all screenings in 16 patients (25%). ANA were found in 41 patients (65%), AMA in 4 (6%), ASMA in 4 (6%), ANCA in 7 (11%), ACLA in 1 (2%), anti-thyroid antibodies in 3 (5%), and anti-DNA in 2 (3%). More than one antibody occurred in 16/63 (25%) positive patients. ANA was significantly more frequent in patients with chronic GVHD and, among these, in those with the extensive form. The nucleolar pattern of immunofluorescence of ANA but not its titer was correlated with the extension of chronic GVHD. Patients who developed autoantibodies had higher CD20+ cell blood counts than negative patients in the third month (p = 0.006), ninth month (p = 0.061), and twelfth month (p = 0.043).We conclude that patients with chronic GVHD, particularly those with an extensive involvement, were likely to develop autoantibodies and have a faster B-cell recovery, suggesting a role of B cells in the pathogenesis of chronic GVHD.
Sprigs Not Springs
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Walking
Authors: Yehuda Shoenfeld
Journal: JAMA (1980)

This study examined the efficiency of walking with a backpack load as a method for improving physical fitness. Forty-four subjects (average age, 18.8 years) marched at a speed of 5 km/hr for 30 minutes a day, five days a week. Thirty-two subjects walked for 3 weeks with a 3-kg backpack load; 6 subjects marched for 4 weeks with the same load; 6 subjects marched for 3 weeks with a 3-kg load, and with a 6-kg load during the fourth week. A statistically significant increase in aerobic work capacity (Vo<sub>2max</sub>) was observed in all three groups, but was most pronounced in the last group. (<i>JAMA</i>243:2062-2063, 1980)
Autologous Transplantation of Bone Marrow Cells Improves Damaged Heart Function
Authors: Shinji Tomita, Ren-Ke Li, Richard D. Weisel, Donald A. G. Mickle, Eung-Joong Kim, Tetsuro Sakai, Zhi-Qiang Jia
Journal: Circulation (1999)

Background —Autologous bone marrow cells (BMCs) transplanted into ventricular scar tissue may differentiate into cardiomyocytes and restore myocardial function. This study evaluated cardiomyogenic differentiation of BMCs, their survival in myocardial scar tissue, and the effect of the implanted cells on heart function. Methods and Results —In vitro studies: BMCs from adult rats were cultured in cell culture medium (control) and medium with 5-azacytidine (5-aza, 10 μmol/L), TGFβ1 (10ng/mL), or insulin (1 nmol/L) (n=6, each group). Only BMCs cultured with 5-aza formed myotubules which stained positively for troponin I and myosin heavy chain. In vivo studies: a cryoinjury-derived scar was formed in the left ventricular free wall. At 3 weeks after injury, fresh BMCs (n=9), cultured BMCs (n=9), 5-aza–induced BMCs (n=12), and medium (control, n=12) were autologously transplanted into the scar. Heart function was measured at 8 weeks after myocardial injury. Cardiac-like muscle cells which stained positively for myosin heavy chain and troponin I were observed in the scar tissue of the 3 groups of BMC transplanted hearts. Only the 5-aza–treated BMC transplanted hearts had systolic and developed pressures which were higher ( P &lt;0.05) than that of the control hearts. All transplanted BMCs induced angiogenesis in the scar. Conclusions —Transplantation of BMCs induced angiogenesis. BMCs cultured with 5-aza differentiated into cardiac-like muscle cells in culture and in vivo in ventricular scar tissue and improved myocardial function.
Drug Disposal
Authors: Bridget M. Kuehn
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal