tbuckley/cabot-search huggingface dataset:
Abstract 5270: A potential role of branched chain amino acid metabolism in breast cancer cell invasiveness
Authors: Maxwell B. Colonna, Arthur S. Edison, Shaying Zhao
Journal: Cancer Research (2019)

Abstract Carcinomas have two broadly distinct modes of invasion: collective and individual. Collective invasion is characterized as groups of cells that migrate while retaining cell-cell contacts. Individual invasion occurs through mechanisms such as the acquiring of mesenchymal-like features by cancer cells. While these different modes of invasion have been well studied at the genomic and transcriptional levels, their metabolic alterations remain much less understood. To address this deficiency, we performed untargeted NMR metabolomics, in conjunction with RNA-seq, on two variants of MCF7, a widely used breast cancer cell line. We report herein several findings. First, the two MCF7 variants, one parental (referred to as MCF-7 hereafter) and another having undergone many passages (referred to as Augusta hereafter), differ morphologically, with MCF-7 being more epithelial and Augusta being more mesenchymal-like. Importantly, fibroblast co-culture experiments indicate that MCF-7 cells resemble collective invasion, while Augusta cells resemble individual invasion. Furthermore, both scratch-assay and gene set enrichment analysis of RNA-seq data indicate that Augusta cells are more invasive. Second, our NMR metabolomics analysis reveals that branched chain amino acids (BCAAs) represent a significant metabolic difference between MCF-7 and Augusta cells. Partial least squares discriminant analysis of the metabolomics data identified BCAAs as essential distinguishing features between the two cell lines. Specifically, compared to MCF-7 cells, BCAAs are significantly depleted inside Augusta cells, consistent with the upregulation of several key BCAA degradation genes. We hypothesize that Augusta cells can more efficiently utilize BCAAs, and are performing 13C-labeled BCAA flux analysis to test this hypothesis. Previous studies have shown that an aberrantly expressed BCAA metabolism gene sustains growth and enhances invasiveness of breast cancer cells. However, increased catabolism of BCAAs has not been reported in literature on this subject. Our simple cell line model allows for a deeper molecular understanding of BCAA metabolism in breast cancer cell invasion. Citation Format: Maxwell B. Colonna, Arthur S. Edison, Shaying Zhao. A potential role of branched chain amino acid metabolism in breast cancer cell invasiveness [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5270.
X-Ray Seminar Number 15
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Burning feet.
Journal: BMJ (1972)

differing circumstances.Having designed the machine and watched it in motion for five years the working party now feels that it can be steered effectively into the new relationships which will arise when the N.H.S. is reorganized in 1974.At the same time Sir George Godber and his col- leagues wish to withdraw from the scene in favour of a new team.They deserve the thanks of all Health Service staff for their several efforts to find a flexible administrative struc- ture-linking medicine and management-in which the energies and ideas of hospital doctors can be harnessed to make the best use of our limited N.H.S. resources.
MANIFESTATIONS OF ANOXEMIA
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Local delivery of low-dose docetaxel, a novel and potent anti microtubular agent, reduces neointimal hyperplasia in a balloon-injured rabbit iliac artery model Satoshi Yasuda, Teruo Noguchi, Masahiro Gohda, Takashi Arai, Nobumasa Tsutsui, Yasuhide Nakayama, Takehisa Mastuda, Hiroshi Nonogi. National Cardiovascular Center, Suita, Osaka, Japan, Tokai Medical Products, Aichi, Japan
Journal: Journal of the American College of Cardiology (2001)
Tinea faciei simulating other dermatoses
Authors: L. Shapiro
Journal: JAMA (1971)

<i>In four cases of tinea faciei due to</i>Trichophyton mentagrophytes<i>each patient's dermatosis was clinically deceptive, and had masqueraded under diagnoses such as lupus erythematosus or contact dermatitis for periods of up to five months. A greater awareness of the possibility of unusual forms of facial ringworm should increase the number of cases in which it is correctly diagnosed</i>.
Cutaneous infection due to Mycobacterium kansasii
Authors: J. D. Maberry
Journal: JAMA (1965)

IN THE RECENT literature the atypical or unclassified mycobacteria have become more apparent. Pulmonary infections due to these organisms have been recognized which simulated tuberculosis. More recently, cutaneous lesions have been reported. This report was prompted by the observation of a primary cutaneous infection of some 22 years' duration caused by<i>Mycobacterium kansasii</i>. No similar cases due to this organism were found in a review of the literature. <h3>Report of a Case</h3> The patient is a 42-year-old white man, a rice farmer from the south Texas Gulf Coast. At the age of 11, while roller-skating on a concrete sidewalk, he sustained a 3inch laceration of the right knee which healed uneventfully. He frequently swam in the public swimming pool, but remembered no trauma related to this. He first developed a verrucose growth on his right knee in 1943, at the age of 21, while in military service. There had been
Author's reply
Authors: G S Panayi
Journal: Annals of the Rheumatic Diseases (1995)

Effect of gold treatment on cytokine expression in synoviumA recent paper in this journal described the effect of intramuscular gold treatment on cytokine expression in synovial membranes from patients with rheumatoid arthritis.1In that paper, the authors described changes in synovial membrane expression of interleukins (IL) IL-1a, IL-1,, IL-6, and tumour necrosis factor a in patients who had received intra- muscular gold treatment.However, the authors failed to mention that some of the results had been published in another journal by a similar group of authors.2Neither paper is cross referenced in the other, and it is not clear from these two papers whether the authors are reporting the same set of results in two different papers.In one paper,2 the authors described a significant failure rate with blind needle biopsy of the synovial membrane, which is particularly a problem with studies involving sequential biopsying as was performed in these two studies.Our experience is similar with this technique and we have now changed to performing all synovial biopsying under direct vision through a needle arthroscope under local anaesthesia.However, despite the fact that the two patient groups appear to be similar, if not identical, in these two papers, one paper states that only seven of 18 patients recruited in the study gave three satisfactory sequential synovial biopsy specimens,2 while the other paper implies, though does not clearly state, that satisfactory synovial biopsy specimens were obtained in all 10 patients for all time points (0, 2, and 12 weeks).1This suggests either that the authors' biopsying technique or success rate has changed dramatically during the period between preparation of the two papers, or that additional patients were obtained to 'make up the numbers'.Could the authors please confirm whether:(1) The patient groups studied in these two papers are, in fact, identical.(2) The same results for IL-1,B have been published in two different papers in two different journals.(3) All the patients reported in one paper' provide adequate synovial biopsy specimens for all three time points and, if so, how was this possible in view of the results and discussion in the other paper from the same group.
THE NEW YORK STATE MEDICAL ASSOCIATION.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum to: Transcriptome and proteome mapping in the sheep atria reveal molecular features of atrial fibrillation progression
Authors: Alba Alvarez-Franco, Raquel Rouco, Rafael J Ramirez, Guadalupe Guerrero-Serna, Maria Tiana, Sara Cogliati, Kuljeet Kaur, Mohammed Saeed, Ricardo Magni, Jose Antonio Enriquez, Fatima Sanchez-Cabo, José Jalife, Miguel Manzanares
Journal: Cardiovascular Research (2021)
Non-irritating skin test concentrations for ceftazidime and aztreonam in patients with a documented beta-lactam allergy
Authors: Marie-Line Van Der Poorten, Margo Hagendorens, Athina Van Gasse, Margaretha Faber, Leander De Puysseleyr, Jessy Elst, Antonino Romano, Didier Ebo, Vito Sabato
Journal: Journal of Allergy and Clinical Immunology (2021)
QUANTITATIVE DETERMINATION OF COCAIN AND ATROPIN ABSORPTION BY AQUEOUS HUMOR
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Academic Excellence
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2214: COUP-TFII suppresses NFκB activation in endocrine-resistant breast cancer cells
Authors: Lacey M. Litchfield, Carolyn M. Klinge
Journal: Cancer Research (2012)

Abstract COUP-TFII is an orphan nuclear receptor that can function as either a transcriptional activator or repressor. We have previously shown that COUP-TFII expression is reduced in tamoxifen-resistant LCC9 breast cancer cells and that overexpression of COUP-TFII restored the ability of tamoxifen to inhibit cell proliferation. An increase in NFκB activity and p65/RELA level has been reported in endocrine-resistant breast cancer cells. Because NFκB activation results in increased expression of anti-apoptotic and pro-proliferative genes, increased NFκB signaling promotes the survival of cancer cells. The goal of the current study was to further elucidate the mechanism by which COUP-TFII enables cells to maintain endocrine sensitivity and to determine if COUP-TFII modulates NFκB activity in tamoxifen-resistance. To examine whether COUP-TFII can suppress NFκB activity, MCF-7 (tamoxifen-sensitive, TAM-S) and LCC9 (tamoxifen-resistant, TAM-R) breast cancer cells were transfected with a NFκB luciferase reporter and treated with TNFα to activate NFκB. Cotransfection with COUP-TFII reduced NFκB activity in both TAM-S and TAM-R cell lines. Knockdown of COUP-TFII with siRNA led to an increase in p65 expression; conversely, COUP-TFII overexpression led to a suppression of p65 expression. COUP-TFII overexpression also reduced TNFα-induced endogenous NFκB target gene expression. Preliminary data also suggests that suppression of NFκB activation by COUP-TFII leads to a reduction in cell viability in MCF-7 and LCC9 cells in response to tamoxifen and TNFα treatment. This indicates a novel role for COUP-TFII in suppression of NFκB activity which may explain the ability of COUP-TFII to promote tamoxifen-sensitivity. COUP-TFII may be both a useful biomarker to predict tamoxifen-sensitivity as well as a target to restore endocrine sensitivity to resistant cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2214. doi:1538-7445.AM2012-2214
OP0166 Sustained Development of Cardiovascular Disease in Rheumatoid Arthritis Despite Cardioprotective Treatment: The 10-Year Prospective Carre-Study
Authors: A. M. Van Sijl, I. A. van den Oever, M. J. Peters, V. V. van Halm, A. E. Voskuyl, Y. M. Smulders, M. T. Nurmohamed
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic inflammatory joint disease which is associated with an increased cardiovascular (CV) risk. It is still unknown to what extent this is due to CV risk factors or the underlying inflammatory process in RA. With the advent of effective anti-inflammatory and cardioprotective treatment, this risk might be mitigated or even reduced. <h3>Objectives</h3> The present study compared changes in CV risk factors, RA-related factors and medication use over time in RA-patients who did and did not develop CV disease during follow-up. <h3>Methods</h3> Starting from 2000-2001, 10-year incidence rate of CV disease, CV risk factors, RA-related factors and medication use were assessed in a prospective cohort of 353 RA patients at baseline, at 3-years and at 10-years of follow-up. Associations between the changes in RA related factors and development of CV disease were assessed using generalized estimating equation (GEE) analyses, while changes in all variables were assessed with general linear models (GLM). <h3>Results</h3> After 10 years, there were 58 CV events over 2361 patient years of follow-up, incidence rate (IR) of 25.3/1.000 patientyears. This was similar to the IR at 3-years of follow-up: 22.8/1.000 patientyears. GLM analyses showed that use of antihypertensives, statins, TNF inhibitors and general CV risk increased significantly over time in the entire population, while RA related factors improved significantly (see enclosed figure). GEE analyses showed that increased use of TNF inhibitors was positively associated with less incident CV disease. <h3>Image/graph</h3> <h3>Conclusions</h3> The risk of incident CV disease persists in patients with RA despite the advent of effective anti-inflammatory therapies and increased use of cardioprotective medication in recent years. Patients who used TNF inhibitors and, more indirectly, had a reduction in inflammation or disease activity, were less at risk of developing a CV disease. General CV risk and use of cardioprotective medications did not attenuate this association. <h3>Disclosure of Interest</h3> None Declared
Thyroglobulin and calcitonin in patients with nontoxic goiter
Authors: G. A. Levine
Journal: JAMA (1978)

THE SERUM thyroglobulin (Tg) concentration is elevated in some patients with differentiated thyroid carcinoma.<sup>1</sup>Plasma calcitonin (CT) measurement is a specific screening test for medullary carcinoma of the thyroid.<sup>2</sup>The purpose of our study was to assess the clinical value of measuring plasma thyroglobulin and calcitonin levels in the evaluation of nontoxic goiter. <h3>Patients and Methods</h3> Patients with goiter who attended the endocrine clinics of the Wadsworth Veterans Administration Hospital or the University of California, Los Angeles, Hospital had blood samples drawn during routine visits. All patients had been examined for goiter by standard techniques, including thyroid function tests, antithyroid antibodies, and radioiodine thyroid scans. Thyroid size was estimated by palpation, and nodules were measured with a plastic ruler. In patients with single nodules discovered by palpation, the thyroid size was estimated by adding the mass of the nodule to that of the normal gland, which was assumed
THE NEED OF AN ANATOMIC LAW IN TEXAS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NOTICE
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal