Effects of intubation timing in patients with COVID-19 throughout the four waves of the pandemic: a matched analysis
Authors: Jordi Riera, Enric Barbeta, Adrián Tormos, Ricard Mellado-Artigas, Adrián Ceccato, Anna Motos, Laia Fernández-Barat, Ricard Ferrer, Darío García-Gasulla, Oscar Peñuelas, José Ángel Lorente, Rosario Menéndez, Oriol Roca, Andrea Palomeque, Carlos Ferrando, Jordi Solé-Violán, Mariana Novo, María Victoria Boado, Luis Tamayo, Ángel Estella, Cristóbal Galban, Josep Trenado, Arturo Huerta, Ana Loza, Luciano Aguilera, José Luís García Garmendia, Carme Barberà, Víctor Gumucio, Lorenzo Socias, Nieves Franco, Luis Jorge Valdivia, Pablo Vidal, Víctor Sagredo, Ángela Leonor Ruiz-García, Ignacio Martínez Varela, Juan López, Juan Carlos Pozo, Maite Nieto, José M. Gómez, Aaron Blandino, Manuel Valledor, Elena Bustamante-Munguira, Ángel Sánchez-Miralles, Yhivian Peñasco, José Barberán, Alejandro Ubeda, Rosario Amaya-Villar, María Cruz Martín, Ruth Jorge, Jesús Caballero, Judith Marin, José Manuel Añón, Fernando Suárez Sipmann, Guillermo M. Albaiceta, Álvaro Castellanos-Ortega, Berta Adell-Serrano, Mercedes Catalán, Amalia Martínez de la Gándara, Pilar Ricart, Cristina Carbajales, Alejandro Rodríguez, Emili Díaz, Mari C. de la Torre, Elena Gallego, Luisa Cantón-Bulnes, Nieves Carbonell, Jessica González, David de Gonzalo-Calvo, Ferran Barbé, Antoni Torres
Journal: European Respiratory Journal (2022)

The primary aim of our study was to investigate the association between intubation timing and hospital mortality in critically ill patients with coronavirus disease 2019 (COVID-19)-associated respiratory failure. We also analysed both the impact of such timing throughout the first four pandemic waves and the influence of prior noninvasive respiratory support on outcomes.This is a secondary analysis of a multicentre, observational and prospective cohort study that included all consecutive patients undergoing invasive mechanical ventilation due to COVID-19 from across 58 Spanish intensive care units (ICUs) participating in the CIBERESUCICOVID project. The study period was between 29 February 2020 and 31 August 2021. Early intubation was defined as that occurring within the first 24 h of ICU admission. Propensity score matching was used to achieve a balance across baseline variables between the early intubation cohort and those patients who were intubated after the first 24 h of ICU admission. Differences in outcomes between early and delayed intubation were also assessed. We performed sensitivity analyses to consider a different time-point (48 h from ICU admission) for early and delayed intubation.Of the 2725 patients who received invasive mechanical ventilation, a total of 614 matched patients were included in the analysis (307 for each group). In the unmatched population, there were no differences in mortality between the early and delayed groups. After propensity score matching, patients with delayed intubation presented higher hospital mortality (27.3% versus 37.1%; p=0.01), ICU mortality (25.7% versus 36.1%; p=0.007) and 90-day mortality (30.9% versus 40.2%; p=0.02) compared with the early intubation group. Very similar findings were observed when we used a 48-h time-point for early or delayed intubation. The use of early intubation decreased after the first wave of the pandemic (72%, 49%, 46% and 45% in the first, second, third and fourth waves, respectively; first versus second, third and fourth waves p<0.001). In both the main and sensitivity analyses, hospital mortality was lower in patients receiving high-flow nasal cannula (HFNC) (n=294) who were intubated earlier. The subgroup of patients undergoing noninvasive ventilation (n=214) before intubation showed higher mortality when delayed intubation was set as that occurring after 48 h from ICU admission, but not when after 24 h.In patients with COVID-19 requiring invasive mechanical ventilation, delayed intubation was associated with a higher risk of hospital mortality. The use of early intubation significantly decreased throughout the course of the pandemic. Benefits of such an approach occurred more notably in patients who had received HFNC.