tbuckley/cabot-search huggingface dataset:
Abstract 266: Phosphodiesterase 9A Deficiency Does Not Attenuate Chronic-hypoxic Pulmonary Hypertension
Authors: Todd M Kolb, Laura Johnston, Haarika Srinath, Mahendra Damarla, David A Kass, Paul M Hassoun
Journal: Circulation Research (2017)

Background: Phosphodiesterase (PDE) inhibition is a cornerstone of therapy for pulmonary arterial hypertension. A novel role for PDE9A in natriuretic peptide-mediated left ventricular cyclic guanosine monophosphate (cGMP) signaling and remodeling has recently been described. Since cGMP-signaling can promote vaso-relaxation and prevent vascular smooth muscle cell proliferation and cardiac myocyte hypertrophy, we hypothesized that PDE9A deficiency would attenuate right ventricular (RV) and pulmonary vascular remodeling during chronic RV pressure overload. Methods: Chronic-hypoxic pulmonary hypertension (CH-PH) was induced in mice lacking PDE9A expression ( Pde9a -/- ) and wild-type littermates ( Pde9a +/+ ) by exposure to normobaric hypoxia (FiO2 = 10%) for 3 weeks. RV systolic pressures were measured to quantify PH, and RV hypertrophy was quantified as the ratio of RV free wall mass to LV/septal mass (RV/LV+S). Heart, lung, and serum were flash frozen for biochemical analyses. Results: In wild-type mice, exposure to chronic hypoxia resulted in significant increases in RV pressure (30 ± 2.4 vs. 20 ± 3.2 mm Hg; P = 0.0006) and RV hypertrophy (0.34 ± 0.04 vs. 0.25 ± 0.02; P &lt; 0.0001). Serum ANP levels were increased 5-fold with CH-PH ( P = &lt;0.0001), associated with a 72% reduction in lung Npr3 receptor expression (responsible for ANP clearance; P &lt; 0.0001) but no increase in RV Nppa expression. After 3 weeks of CH-PH, tissue levels of cGMP were not increased in lung (993 ± 502 pg/mg vs. 667 ± 210 pg/mg; P = 0.27) or RV (47 ± 18 pg/mg vs. 49 ± 13 pg/mg; P = 0.88) homogenates. Accordingly, serine-239 phosphorylation of vasodilatory-stimulated phosphoprotein (VASP; a surrogate for protein kinase G activation) was not increased by CH-PH in lung or RV. Expression of Pde9a RNA was not increased by CH-PH in lung or RV. Pde9a -/- mice did not have attenuated CH-PH induced increases in RVH ( P = 0.27, 2-way ANOVA) or RVSP ( P = 0.23, 2-way ANOVA) when compared to Pde9a +/+ mice. In both Pde9a -/- and Pde9a +/+ mice, CH-PH was associated with significant increases in lung PDE5A expression. Conclusions: In a murine model of chronic RV pressure overload, PDE9A deficiency does not attenuate RV remodeling or PH, despite robust increases in circulating natriuretic peptide levels.
THE ITHACA TYPHOID EPIDEMIC.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical medicine is not dead, but is living in Baltimore...
Authors: E. J. H.
Journal: Annals of Internal Medicine (1969)

The Literature of Medicine1 June 1969Clinical medicine is not dead, but is living in Baltimore...E. J. H.E. J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-6-1283 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFrom time to time, some medical publisher treats me to a couple of martinis. Nothing is free, I wait for the question. After the pleasantries, it comes. "What kind of textbook of medicine is needed today?" Which is a genteel translation of, "How can I strike it big?" His question is not rhetorical. Nor is the answer obvious; if it were, he would be wasting three dollars on one martini for him and two for me.Any answer, on the textbook of internal medicine or any other medical discipline, for tomorrow or five years from now would be little more...* STRASSMANTAYLORSCOLES HDDDJ: A new concept for a core medical curriculum. J. Med. Educ. 44: 170, 1968. LEE P. V.: Some problems of curricular innovation. J. Amer. Geriat. Soc. 17: 254, 1969. Google Scholar* WYNGAARDEN JB: Current problems of undergraduate medical curricula. Arthritis Rheum. 11 (part 2): 235, 1968. CrossrefGoogle Scholar* The teaching of the basic medical sciences. WHO Chron. 23: 37, 1969. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1969Volume 70, Issue 6Page: 1283-1287 ePublished: 1 December 2008 Issue Published: 1 June 1969 PDF downloadLoading ...
Medical Pests
Authors: Jack R. Harnes
Journal: JAMA (1976)

RECENTLY, a group exchanged our personal experiences with zealots intent on converting us to their religions. We understood their motivation and admired their devotion to their church and its tenets. Nevertheless, we agreed that when such individuals persisted in conversion attempts in the face of polite but firm disinterest, they became pests. Later, I read that some physicians were proposing that doctors who smoke cigarettes should lose their hospital privileges and perhaps their licenses to practice medicine. I realized then that physician proselytizers, like religious proselytizers, were pests. Like the religious zealot, the medical zealot refuses to admit that others are aware of his or her beliefs. The zealot also refuses to admit that others may have weighed the pros and cons of conversion and have decided to risk damnation by continuing their sinful ways. Smoking, lack of exercise, and high-fat diets are the major targets of our current medical
Alcoholic women in medicine: still homeless
Authors: E. M. Steindler
Journal: JAMA (1987)

Alcoholism and other drug dependencies in women have been coming out into the open, coterminous with women leaving the home and entering the work force. Part of what is now recognized as being a major drug addiction problem in women has been there all along—it was simply hidden behind residential walls. Much of it is new, however, and apparently linked to the stresses and pressures of changing roles, the competing demands of occupational pursuits and raising children, the breakdown of the nuclear family, and other social and economic phenomena.<sup>1,2</sup> We are just at the threshold of being able to understand the influence of such factors on the inception and manifestation of alcoholism, yet one piece of information that has already emerged is that alcoholism expresses itself differently in women and in men.<sup>3</sup>For instance, more women than men use sedative drugs in addition to alcohol. Women tend to
Editorial: Outpatient treatment of haemorrhoids.
Journal: BMJ (1975)

The estrogenic potency of combined oral contraceptives (OC) is discussed. A dose of 30-50 mcg estrogen was recommended once it was learned that the incidence of thromboembolic disease was related to the estrogen content of OCs. The synthetic progestogens in OCs are usually nortestosterone derivatives, many of which are partly metabolized to estrogen when taken orally. It is difficult, however, to determine whether pills with lowered estrogenicity will reduce the incidence of thromboembolic disorders. Norethynodrel has a purely additive effect on the estrogenicity of estrogens, norgestrel is antagonistic, while norethindrone and ethynodiol diacetate have less estrogenic action at high doses and more action at low doses. It is doubtful that the standard measure for estrogenicity in the mouse uterus is applicable to the association of thromboembolic disease and OC use. The only way to resolve the question is by a more complete epidemiological analysis, which requires greater cooperation in the reporting of thrombotic incidents.
Reply
Authors: Burton Combes, Scott S. Emerson
Journal: Hepatology (2006)

We do not feel that further studies of methotrexate in PBC need be precluded by the results of the PUMPS trial.1 Our only request is that any future trials be adequately controlled, contain a sufficient number of patients, and be aimed at demonstrating an effect on hard endpoints of the disease such as preventing complications; the need for transplantation; or delaying time to death. In lieu of this, the quality of life should be improved by treatment. We are not surprised that a uniform response to one therapy is not observed in PBC. Clearly, the effects of many polymorphisms are being observed in both the pathogenesis and the response to tissue injury in many diseases, and this undoubtedly applies to PBC as well. In their recent review of PBC,2 Drs. Kaplan and Gershwin proposed an untested form of therapy, i.e., the addition of colchicine to ursodiol, if 1 year of therapy with the latter was deemed inadequate; then the addition of methotrexate after an additional year if the previously combined therapy was inadequate. An adequate response was said to consist of resolution of pruritus, a decrease in serum alkaline phosphatase activity to less than 50% above normal, and improvement in liver histological findings. Yet, to date, none of these latter responses, individually or collectively, has served as an adequate surrogate for the hard endpoints of prevention of complications of liver disease, of preventing the need for liver transplantation, for prolongation of survival free of liver transplantation, or for improving the quality of life. Burton Combes M.D.*, Scott S. Emerson M.D., Ph.D. , * The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, The University of Washington School of Public Health and Community Medicine, Seattle, WA
Esophageal Cysts
Authors: Gerard Desforges, John W. Strieder
Journal: New England Journal of Medicine (1960)

ESOPHAGEAL cysts form a group of rare and interesting mediastinal tumors.1 There can be no doubt that this type of cyst is closely related embryologically to those called bronchogenic, gastric or enteric cysts of the mediastinum. It seems probable that they form as the result of the pinching off of accessory buds from the primitive foregut or from the tracheobronchial branches, and thus might better be termed "primitive foregut cysts." Those within the esophageal wall form a distinct clinical group in that the symptomatology is quite different from those in other areas.Although they may be asymptomatic, the possibilities inherent . . .
Registration
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Natural history of 610 adults with asymptomatic hemodynamically significant aortic stenosis over prolonged follow-up Patricia A. Pellikka, Rick A. Nishimura, Kent R. Bailey, Marion E. Barnes, Youseff F. Malouf, E. Marcony Juracan, Daniel Tiede, Tanya Taylor, A. Jamil Tajik. Mayo Clinic, Rochester, MN
Journal: Journal of the American College of Cardiology (2001)
MADRID
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BATEMAN—LITERARY EXECUTOR OF WILLAN
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metabolic alkalosis after massive blood transfusion. Correction by hemodialysis
Authors: C. G. Barcenas
Journal: JAMA (1976)

METABOLIC alkalosis is commonly observed after major surgery. It is usually due to loss of acid by gastric suction and increased bicarbonate regeneration by the kidneys.<sup>1</sup> We report a case in which the administration of large amounts of blood provided an exogenous load of bicarbonate precursors that worsened a preexisting alkalosis. The latter was promptly corrected by hemodialysis. <h3>Report of a Case</h3> A 48-year-old man maintained on hemodialysis since 1969 was admitted to the hospital on June 12, 1975, with the acute onset of bleeding in the upper portion of the gastrointestinal tract that was shown, on endoscopic examination, to originate from a duodenal ulcer. He received antacids and 9 units of leukocyte-poor packed red blood cells (RBCs) during the following week because of intermittent bleeding. On the 12th day, he underwent vagotomy, pyloroplasty and oversewing of a bleeding duodenal ulcer. One week later, a gastrostomy was done after
SOFTWARE
Authors: Alan S. Kaplan
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Induced Fertility
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MARRIAGE AMONG DEAF.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OCULAR PEMPHIGUS.
Authors: R. E. CHURCH, I. B. SNEDDON
Journal: British Journal of Dermatology (1953)

Journal Article OCULAR PEMPHIGUS. Get access R. E. CHURCH, M.A., M.B., M.R.C.P.Ed., R. E. CHURCH, M.A., M.B., M.R.C.P.Ed. Senior Registrar Rupert Hallam Department of Dermatology, The Royal Infirmary, Sheffield Search for other works by this author on: Oxford Academic Google Scholar I. B. SNEDDON, M.B., Ch.B., M.R.C.P. I. B. SNEDDON, M.B., Ch.B., M.R.C.P. Consultant Dermatologist Rupert Hallam Department of Dermatology, The Royal Infirmary, Sheffield Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 65, Issue 7-8, 1 July 1953, Pages 235–245, https://doi.org/10.1111/j.1365-2133.1953.tb13745.x Published: 01 July 1953
Recurrent tetanus.
Authors: R. D. Montgomery
Journal: BMJ (1968)

course disfiguring and leaves her with a permanent vaccination scar on her face.Ballet dancers who have to be lifted by male partners do not like to be vaccinated on the shoulder because of the visibility of the scar and the dressing, but also complain bitterly of burst vaccination blisters on the thigh.Where indeed can such ballet dancers be vaccinated ?-I am, etc., Slough, Bucks.N. C. HYPHER.Meniscectomy and Degenerative Change SIR,_-Mr.J. P. Jackson (1 June, p. 525) suggests that the damage to the articular cartilage in a knee joint occurs as a result of removing a meniscus, and appears to ignore the fact that the articular cartilage is damaged by the trauma which produced the tear in the meniscus.
BOOK REVIEWS
Authors: WYNDHAM H. WILSON
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article BOOK REVIEWS Get access Colony-Stimulating Factors: Molecular and Cellular Biology, Immunology Series, Volume 49 . T. Michael Dexter , John M. Garland , Nydia G. Testa , eds. New York : Marcel Dekker, Inc. , 1990 , 475 pp. $135. WYNDHAM H. WILSON WYNDHAM H. WILSON Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 12, 20 June 1990, Pages 1064–1065, https://doi.org/10.1093/jnci/82.12.1064-a Published: 20 June 1990
Age-Related Macular Degeneration
Authors: Rama D. Jager, William F. Mieler, Joan W. Miller
Journal: New England Journal of Medicine (2008)

Age-related macular degeneration is the leading cause of irreversible blindness in people 50 years of age or older in the developed world. This article reviews the clinical and histopathological features of age-related macular degeneration and its genetics and epidemiology and discusses current management options and research advances.
Quality assurance and the clinical laboratory
Authors: E. T. Wong
Journal: JAMA (1988)

The fundamental role of the laboratory is to provide information to help answer questions about the diagnosis of illness and the care of patients. The Joint Commission on Accreditation of Healthcare Organizations (JCAHO) requires that clinical laboratories participate in hospitalwide quality-assurance programs to monitor and evaluate the appropriateness of medical laboratory services and to correct problems that are identified and deal with clinical situations that require improvement.<sup>1</sup>Quality-control programs now in place in clinical laboratories address only the integrity of the process that produces laboratory test results, not whether those tests benefit patient care. See also p 2549. In response to the new standard, it has been suggested that laboratories gather a plethora of statistics (so-called<i>quality indicators</i>).<sup>2</sup>Such indicators may identify trends in laboratory operations but tell little about how those laboratory services relate to patient care. Unless it is interpreted and used to improve patient care,