The Biological Properties of Etiocholanolone
Authors: SHELDON M. WOLFF
Journal: Annals of Internal Medicine (1967)

Clinical Staff Conference1 December 1967The Biological Properties of EtiocholanoloneCombined Clinical Staff Conference at the National Institutes of HealthSHELDON M. WOLFF, M.D., F.A.C.P., HARRY R. KIMBALL, M.D., SEYMOUR PERRY, M.D., F.A.C.P., RICHARD ROOT, M.D., ATTALLAH KAPPAS, M.D., F.A.C.P.SHELDON M. WOLFF, M.D., F.A.C.P.Search for more papers by this author, HARRY R. KIMBALL, M.D.Search for more papers by this author, SEYMOUR PERRY, M.D., F.A.C.P.Search for more papers by this author, RICHARD ROOT, M.D.Search for more papers by this author, ATTALLAH KAPPAS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-6-1268 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. Sheldon M. Wolff: In 1956 Dr. Attallah Kappas and Hellman, Fukushima, and Gallagher (1) first reported that the steroid metabolite etiocholanolone caused fever when it was administered to man. Subsequent work by the same investigators and others has substantiated the pyrogenic properties of etiocholanolone (2) and other 5 beta-H C19, C21, and C24steroids (3). These observations are especially noteworthy since they describe biologic activity possessed by a class of compounds previously thought to be physiologically inert and since they represent the first discovery of pyrogenic substances of endogenous origin in man. Interest in etiocholanolone was heightened considerably by...References1. KAPPASHELLMANFUKUSHIMAGALLAGHER ALDKTF: The pyrogenic effect of etiocholanolone (3α-hydroxyetiocholane-17-one). J. Clin. Endocr. 16: 948, 1956. Google Scholar2. SEGALOFFBOWERSGORDONSCHLOSSERMURISON ACYDLJVPJ: Hormonal therapy in cancer of the breast. XII. 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