tbuckley/cabot-search huggingface dataset:
Orthotopic liver transplantation for incurable alveolar echinococcosis of the liver: Report of 17 cases
Authors: S Bresson-Hadni
Journal: Hepatology (1991)

Between 1986 and 1989, orthotopic liver transplantations were performed in our unit for 17 patients with incurable alveolar echinococcosis. Ten patients had hilar involvement (group I), and seven patients had posterior localization (five of them had chronic Budd-Chiari syndrome) (group II). The delay between diagnosis and the orthotopic liver transplantation was more than 48 mo in group Ia (six patients), less than 24 mo in group Ib (four patients) and less than 48 mo in group II. Previous operations were more common in group Ia than in group Ib and II. Five patients have died–four in group I and one in group II. The actuarial survival rate at 15 mo was 75%. Early reoperations were frequent (69%), mainly caused by rebleeding. Bacterial and fungal infections occurred only in group Ia (four cases) and group II (three cases). In eight patients (palliative group), residual foci of infected nonhepatic tissue occurred after surgery. The titer of specific antibodies decreased during the first 3 mo in all the patients but one. In patients with radical liver transplantation, the complete disappearance of specific antibodies occurred within 2 yr in four cases. In the remaining five patients, specific antibodies remained detectable, but no evidence of recurrence has been obtained up to now. In the palliative group, a peak of specific IgM occurred at 3 mo; an increase of specific IgG was observed later. The growth of residual parasitic foci was relatively slow, and all these patients remained asymptomatic with a mean follow-up of 19 mo. We conclude that orthotopic liver transplantation is feasible in incurable alveolar echinococcosis and could be proposed without delay to patients with parasitic Budd-Chiari syndrome or complicated secondary biliary cirrhosis. In the other cases, the best time to perform an orthotopic liver transplantation is more difficult to determine. Nevertheless, in the perspective of an orthotopic liver transplantation, the management of these patients has to change, and repetitive laparotomies for palliative surgical procedures have to be replaced by interventional radiology. (HEPATOLOGY 1991;13:1061–1070.)
Index of the Periodical Dental Literature. Published in the English Language, Including Sixty-Five Publications in England, Scotland, Canada, Australia, New Zealand and the United States, for the Five Years, 1911-1915.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metastasis-associated PRL-3 induces EGFR activation and addiction in cancer cells
Authors: Abdul Qader Omer Al-aidaroos, Hiu Fung Yuen, Ke Guo, Shu Dong Zhang, Tae-Hoon Chung, Wee Joo Chng, Qi Zeng
Journal: Journal of Clinical Investigation (2013)

In Figure 7, C and D, the term AG-1478
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1964)

COMMITTEE ON MATERNAL WELFARELupus ErythematosusA twenty-five-year-old Chinese-American gravida 4, para 0, was admitted at twenty weeks of pregnancy after painful contractions for seven days and vaginal passage of tissue for two days.Five years earlier the patient was treated with cortisone for lupus erythematosus disseminatus following an episode of fever, arthralgia, pneumonitis, pleural effusion and a butterfly facial rash. An L.E.-cell test was positive, and there was proteinuria, with a hematocrit of 25 mm. A mild exacerbation the next year did not require admission. There was recurrent blanching of the fingers when she was subjected to cold and . . .
Retraction: Hyaluronan Activation of the Nlrp3 Inflammasome Contributes to the Development of Airway Hyperresponsiveness
Authors: John W. Hollingsworth
Journal: Environmental Health Perspectives (2015)

The authors request retraction of "Hyaluronan Activation of the Nlrp3 Inflammasome Contributes to the Development of Airway Hyperresponsiveness." Due to concerns about the initial data from the animal physiology laboratory at Duke, the authors re-exported source data from the Flexivent machine and compared these data with raw data originally received from the animal pulmonary physiology laboratory.Results from these initial comparisons suggested potential inconsistencies in the data.Therefore, the authors proceeded to replicate experiments of animal airway physiology presented in Figure 2A.These replicate experiments failed to validate the originally reported role of Nlrp3, ASC, and caspase 1 in airway hyperresponsiveness after exposure to ozone.These observed inconsistencies significantly impact the overall conclusions of the manuscript.Therefore,
Critical limits for urgent clinician notification at US medical centers
Authors: G. J. Kost
Journal: JAMA (1990)

A national survey determined critical limits used by trauma and medical centers in the United States. Mean low and high critical limits for the most frequently listed tests were the following values: glucose, 2.6 and 26.9 mmol/L; potassium, 2.8 and 6.2 mmol/L; calcium, 1.65 and 3.22 mmol/L; sodium, 120 and 158 mmol/L; hematocrit, 0.18 and 0.61; hemoglobin, 66 and 199 g/L; platelets, 37 × 10<sup>9</sup>/L and 910×10<sup>9</sup>/L; and white blood cell count, 2.0×10<sup>9</sup>/L and 37.0×10<sup>9</sup>/L. The high critical limit for prothrombin time was 27 seconds. Critical limits for Pco<sub>2</sub>were 19 and 67 mm Hg; and for<sub>p</sub>H, 7.21 and 7.59. The low critical limit for Po<sub>2</sub>was 43 mm Hg; no high critical limit was listed. The noncritical span for free calcium was 0.80 mmol/L. Important qualitative critical results included the presence of blasts on the blood smear, a Gram's stain or culture from blood or cerebrospinal fluid with positive results, and an elevated white blood cell count in the cerebrospinal fluid. A product of 15 years of collective medical judgment, these data should help physicians improve the quality and efficiency of acute patient care. (<i>JAMA</i>. 1990;263:704-707)
Allergen and Endotoxin Exposure, Infection, and Breastfeeding in Early Life, and Recurrent Wheezing in Children: 48-month Follow-up of a Cohort Study
Authors: V.E.V. Rullo, L.K. Arruda, V. Valente, A.S. Zampolo, M.R. Cardoso, F.J. Nóbrega, C.S.K. La Scala, L.C.L. Oliveira, C.K. Naspitz, D. Solé
Journal: Journal of Allergy and Clinical Immunology (2009)
Thrombolytic Therapy
Authors: D Collen, D C Stump, H K Gold
Journal: Annual Review of Medicine (1988)

Thrombolytic agents are plasminogen activators that convert plasminogen, the inactive proenzyme of the fibrinolytic system in blood, to the proteolytic enzyme plasmin. Plasmin in turn dissolves the fibrin of a blood clot, but may also degrade normal components of the hemostatic system and predispose to bleeding. The first-generation thrombolytic agents, streptokinase and urokinase, are only moderately efficacious, and their administration is associated with extensive systemic fibrinogen breakdown. In three major clinical trials in patients with acute myocardial infarction, early intravenous streptokinase significantly reduced in-hospital mortality. Tissue-type plasminogen activator (t-PA) is a more effective and fibrin-specific coronary arterial thrombolytic agent than streptokinase, but its impact on mortality remains to be established. Single-chain urokinase-type plasminogen activator (scu-PA, pro-urokinase) is more fibrin specific than urokinase but has only reached the stage of early clinical investigation. The acylated plasminogen streptokinase activator complex (Apsac) has a profile of thrombolytic efficacy and fibrin specificity that is probably very similar to that of streptokinase, but it can be administered as a single bolus injection. New trends toward further improved efficacy and fibrin specificity of thrombolytic therapy include the use of combinations of synergistic thrombolytic agents, mutants of t-PA or scu-PA, chimeric t-PA/scu-PA molecules, or antibody-targeted thrombolytic agents.
The Snags
Authors: Judith Skillman
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BLOOD-LETTING.
Authors: GEORGE HAMILTON
Journal: JAMA (1883)

In theJournal Of the American Medical Associationfor September 22d, is an article entitled “Good Remedies out of Fashion,” by Dr. C. T. Hare, President of the Metropolitan Counties Branch of the British Medical Association, in relation to emetics and blood-letting. In regard to the utility of emetics in the cases adduced there are probably very many who coincide with the opinions of Dr. Hare, while, in reference to the propriety of bleeding in the congestive conditions alluded to, and others of a similar nature, a vast majority of practitioners, including nearly all the younger, would, perhaps, withhold their assent. The signs of the times, however, seem to indicate that a beneficial change of opinion upon this subject is about to occur; and the writer cannot but express his gratification that another distinguished authority has added his testimony in favor of a practice that, abused as it may have
"SCIENTIFIC WORK MISREPRESENTED AND COMMERCIALIZED."
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Resuscitation after myocardial infarction. A clinical appraisal
Authors: E. Corday
Journal: JAMA (1967)

Cardiac arrest is considered to have occurred when the heart is unable to provide sufficient output to sustain life. Essentially, therefore, cardiac arrest results from ventricular asystole, ventricular fibrillation, or downward displacement of the pacemaker with ineffectual ventricular systole. Each mechanism of arrest requires accurate diagnosis because each necessitates a specific treatment. Positive diagnosis can only be made from an electrocardiographic signal. The specific treatment of ventricular asystole or standstill is electrical pacemaking, of ventricular fibrillation the treatment is electrical defibrillation, while there is no means yet available specifically to reverse the lack of ventricular function due to a downward displacement of the pacemaker. When prompt specific and supportive therapy is utilized, the outlook in ventricular asystole and ventricular fibrillation is relatively favorable, while in downward displacement of the pacemaker, it is poor. <h3>Why Resuscitation?</h3> Until recently, to resuscitate or not has been the source of considerable controversy. Some physicians
Electricity: What It Is and How It Acts.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1704: Predicting survival and improving treatment for uterine serous carcinoma patients using USC78, a genomic risk score
Authors: Lynn K. Tran, Emily K. Myers, David P. Mysona, Paul M. Tran, Wonsok Lee, John J. Wallbillich, Daniel Kleven, Sharad Ghamande, Jin-Xiong She
Journal: Cancer Research (2019)

Abstract Uterine serous carcinoma (USC) is a rare but particularly invasive histological subtype of uterine cancer, the most common gynecologic malignancy in developed countries. Though previous studies with small sample sizes have been conducted to identify transcriptomic and proteomic biomarkers for USC, none have resulted in a clinical assay for patient risk stratification. I have discovered a panel of 78 genes highly upregulated in poor prognosis patients from The Cancer Genome Atlas (TCGA) USC dataset. To create a composite score for our biomarker panel, I applied a machine learning algorithm (elastic net regression) to the TCGA USC gene expression data set to generate a model which outputs a linear predictor score (USC78) based on individual patients’ expression of the 78 genes from our signature. I then quantified gene expression from formalin-fixed paraffin embedded (FFPE) tumor tissue in our cohort of Augusta University (AU) patients and calculated their USC78 score to demonstrate the ability of this model to separate good and poor survival prognosis in a single-center, retrospective validation study. In both TCGA and AU, higher USC78 scores are associated with worse overall survival. This score is also able to risk stratify serous ovarian carcinoma patients in the TCGA data set, suggesting that USC78 may be an important prognosis prediction tool in serous gynecological cancers. Additionally, network analysis of these genes reveals increased TGF-B signaling correlates with the poor-prognosis USC78-high tumor expression profile. TGF-B inhibition has demonstrated chemosensitization effects in primary USC tumor cell lines. I aim to use USC78 to better understand the biological mechanisms behind poor survival prognosis in USC patients and identify potential therapeutic targets for USC. One such target is TGF-B inhibition, and further knockdown, overexpression, and inhibitor studies will be conducted to test whether TGF-B inhibition can improve USC patient prognosis. Citation Format: Lynn K. Tran, Emily K. Myers, David P. Mysona, Paul M. Tran, Wonsok Lee, John J. Wallbillich, Daniel Kleven, Sharad Ghamande, Jin-Xiong She. Predicting survival and improving treatment for uterine serous carcinoma patients using USC78, a genomic risk score [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1704.
Warnings Issued on Nonsedating Antihistamines Terfenadine and Astemizole
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Happy Birthday, Endoscopy!
Journal: Endoscopy (2018)

This year – 2019 – is a very special one for Endoscopy: our journal is half a century old! Founded in 1969, Endoscopy was one of the first journals dedicated exclusively to this – back then – relatively new technique and its various instruments. As such, the journal started with a rather large focus – any type of “endoscope” in any kind of medical field was deemed suitable. Thus the first years saw papers on procedures now no longer associated with the journal, such as bronchoscopy, hysteroscopy, retroperitoneoscopy, ureteroscopy – to name but a few – as well as papers concerning the GI tract. Another feature that seems unusual from today’s perspective was the fact that the journal accepted and published articles in French, German, and English – underlining, however, the early international orientation of Endoscopy, before English finally became the lingua franca of modern scientific publishing.
Syphilis in General Practice with Special Reference to the Tropics.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase 2 Study of the All-Oral Combination of Ixazomib Plus Cyclophosphamide and Low-Dose Dexamethasone (ICd) in Patients (Pts) with Relapsed/Refractory Multiple Myeloma (RRMM)
Authors: Shaji Kumar, Norbert Grzasko, Sosana Delimpasi, Wieslaw W Jędrzejczak, Sebastian Grosicki, Marie-Christine Kyrtsonis, Andrew Spencer, Neeraj Gupta, Zhaoyang Teng, Catriona Byrne, Richard Labotka, Meletios A Dimopoulos
Journal: Blood (2016)
National Cancer Institute Monograph 30, May 1969 “Human Tumor Cell Kinetics”
Journal: JNCI Journal of the National Cancer Institute (1969)

National Cancer Institute Monograph 30, May 1969 “Human Tumor Cell Kinetics” Get access JNCI: Journal of the National Cancer Institute, Volume 42, Issue 5, May 1969, Page 880, https://doi.org/10.1093/jnci/42.5.880 Published: 01 May 1969
Unique vascular skin lesions associated with human immunodeficiency virus
Authors: E. H. Knobler
Journal: JAMA (1988)

We report four patients with antibodies to human immunodeficiency virus and/or acquired immunodeficiency syndrome who were noted to have unique vascular lesions that clinically resembled Kaposi's sarcoma or pyogenic granulomas. The lesions were asymptomatic erythematous-violaceous papules and nodules. They erupted over several weeks, without predilection for a specific cutaneous site. Most lesions resolved spontaneously. Histologically these lesions revealed a proliferation of vascular spaces lined by plump, cuboidal endothelial cells embedded in an edematous stroma with an inflammatory infiltrate. It is unclear if these lesions represent Kaposi's sarcoma or pyogenic granulomas or if they are distinct neoplasms associated with human immunodeficiency virus. (<i>JAMA</i>1988;260:524-527)