tbuckley/cabot-search huggingface dataset:
When Images Speak, Listen
Authors: David O. Williams
Journal: New England Journal of Medicine (2023)

Although revascularization with percutaneous coronary intervention (PCI) was initially reserved for patients with simple coronary artery disease, PCI has now become the norm for patients with acute or chronic coronary artery disease who have complex coronary-artery anatomy or are at high risk for coronary-artery bypass surgery. Advances in the design of guiding catheters, coronary guide wires and balloons, and stents; in techniques to perform PCI; and in the effectiveness of procedure-related anticoagulant and antiplatelet medications have improved clinical outcomes. These advances have led to high procedural success rates with low incidences of serious complications.1 Intravascular imaging, an established catheterization laboratory . . .
Does the understanding of signalling pathways pave the way to therapies for keratinization disorders?
Authors: Hans C Hennies
Journal: British Journal of Dermatology (2023)

Journal Article Corrected proof Does the understanding of signalling pathways pave the way to therapies for keratinization disorders? Get access Hans C Hennies Hans C Hennies Department of Biological and Geographical Sciences, University of Huddersfield, Huddersfield, UK Correspondence: Hans C. Hennies. Email: h.c.hennies@hud.ac.uk https://orcid.org/0000-0001-7210-2389 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, ljad139, https://doi.org/10.1093/bjd/ljad139 Published: 03 May 2023 Article history Received: 20 April 2023 Accepted: 26 April 2023 Published: 03 May 2023 Corrected and typeset: 14 June 2023
Comment on ‘Plasma metabolomics study in screening and differential diagnosis of multiple primary lung cancer’
Authors: Tianzheng Fang, Xianqiao Wu, Chengwei Zhou
Journal: International Journal of Surgery (2023)

Department of Thoracic Surgery, The First Affiliated Hospital of Ningbo University, Zhejiang, 315020, China Running Title: Plasma metabolomics and multiple primary lung cancer. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Thoracic Surgery, The First Affiliated Hospital of Ningbo University, Zhejiang, 315020, China. E-mail address: [email protected] (C. Zhou). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Zuranolone for the Treatment of Adults With Major Depressive Disorder: A Randomized, Placebo‐Controlled Phase 3 Trial
Authors: Anita H. Clayton, Robert Lasser, Sagar V. Parikh, Dan V. Iosifescu, JungAh Jung, Mona Kotecha, Fiona Forrestal, Jeffrey Jonas, Stephen J. Kanes, James Doherty
Journal: American Journal of Psychiatry (2023)

This study assessed the efficacy and safety of a 14-day treatment course of once-daily zuranolone 50 mg, an investigational oral positive allosteric modulator of the γ-aminobutyric acid type A (GABA
Deep learning radio-clinical signature for predicting neoadjuvant chemotherapy response and prognosis from pretreatment CT images of locally advanced gastric cancer patients
Authors: Can Hu, Wujie Chen, Feng Li, Yanqiang Zhang, Pengfei Yu, Litao Yang, Ling Huang, Jiancheng Sun, Shangqi Chen, Chengwei Shi, Yuanshui Sun, Zaisheng Ye, Li Yuan, Jiahui Chen, Qin Wei, Jingli Xu, Handong Xu, Yahan Tong, Zhehan Bao, Chencui Huang, Yiming Li, Yian Du, Zhiyuan Xu, Xiangdong Cheng
Journal: International Journal of Surgery (2023)

Early noninvasive screening of patients who would benefit from neoadjuvant chemotherapy (NCT) is essential for personalized treatment of locally advanced gastric cancer (LAGC). The aim of this study was to identify radio-clinical signatures from pretreatment oversampled computed tomography (CT) images to predict the response to NCT and prognosis of LAGC patients.LAGC patients were retrospectively recruited from six hospitals from January 2008 to December 2021. An SE-ResNet50-based chemotherapy response prediction system was developed from pretreatment CT images preprocessed with an imaging oversampling method (i.e. DeepSMOTE). Then, the deep learning (DL) signature and clinic-based features were fed into the deep learning radio-clinical signature (DLCS). The predictive performance of the model was evaluated based on discrimination, calibration, and clinical usefulness. An additional model was built to predict overall survival (OS) and explore the survival benefit of the proposed DL signature and clinicopathological characteristics.A total of 1060 LAGC patients were recruited from six hospitals; the training cohort (TC) and internal validation cohort (IVC) patients were randomly selected from center I. An external validation cohort (EVC) of 265 patients from five other centers was also included. The DLCS exhibited excellent performance in predicting the response to NCT in the IVC [area under the curve (AUC), 0.86] and EVC (AUC, 0.82), with good calibration in all cohorts ( P >0.05). Moreover, the DLCS model outperformed the clinical model ( P <0.05). Additionally, we found that the DL signature could serve as an independent factor for prognosis [hazard ratio (HR), 0.828, P =0.004]. The concordance index (C-index), integrated area under the time-dependent ROC curve (iAUC), and integrated Brier score (IBS) for the OS model were 0.64, 1.24, and 0.71 in the test set.The authors proposed a DLCS model that combined imaging features with clinical risk factors to accurately predict tumor response and identify the risk of OS in LAGC patients prior to NCT, which can then be used to guide personalized treatment plans with the help of computerized tumor-level characterization.
Clinical evaluation of the first semi-active total knee arthroplasty assisting robot made in China: a retrospective propensity score-matched cohort study
Authors: Pengfei Yang, Rui He, Kai Lei, Liming Liu, Liu Yang, Lin Guo
Journal: International Journal of Surgery (2023)

The precision of overall alignment and knee morphotype after robot-assisted total knee arthroplasty has been fully confirmed. This study aims to conduct a clinical evaluation of the first China-made semi-active total knee arthroplasty assisting robot.After a 1 : 2 propensity score matching, that is, a matched cohort study, patients were matched to the robot group (52 cases) and the conventional group (104 cases). The robot group received osteotomy according to preoperative planning, while the conventional group adopted preoperative planning based on the full-length radiograph and received conventional osteotomy. Perioperative clinical indicators, such as operation time, tourniquet time, hospitalization days, intraoperative bleeding, and hemoglobin level of the two groups were recorded; radiological indicators of postoperative prosthesis position, including hip-knee-ankle angle, frontal femoral component angle, frontal tibial component angle, lateral femoral component angle, and lateral tibial component angle were also recorded; deviations and outliers of the radiological indicators were calculated.Compared with the conventional group, the operation time and tourniquet time of the robot group were longer, and the postoperative hemoglobin level decreased less, the differences were statistically significant; the lateral tibial component angle of the conventional group was 80.9°±3.6°, which was smaller than 86.7 °±2.3° of the robot group, the difference was statistically significant ( P <0.001); except for lateral femoral component angle, the absolute deviations of the radiological indicators in the robot group were significantly smaller than that in the conventional group ( P ≤0.001); the outliers of the radiological indicators in the robot group were significantly smaller than that in the conventional group with a statistical difference ( P <0.05).Compared with the conventional group, the operation time of the robot group was relatively longer, but the perioperation blood loss was less. The robot group could better control the posterior inclination of the tibial prosthesis, and the absolute deviations and outliers of the prosthesis position were relatively smaller. There was no difference in short-term clinical score between the two groups.
Ownership Data Now Available for Hospice and Home Health Agencies
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Responses to commentary on ‘Efficacy and safety of neoadjuvant immunotherapy in surgically resectable esophageal cancer: a systematic review and meta-analysis’ (Int J Surg 2022;106:106929)
Authors: Zhaoyang Wang, Yuanyong Wang, Yingtong Feng, Xiaolong Yan
Journal: International Journal of Surgery (2023)

aDepartment of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, 1 Xinsi Road, Xi'an 710038, China bDepartment of Cardiothoracic Surgery, the Affiliated Huaihai Hospital of Xuzhou Medical University / the 71th Group Army Hospital of PLA, 236 Tongshan Road, Xuzhou, 221004, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. *Corresponding Author. Address: Department of Thoracic Surgery, Tangdu Hospital, Air Force Medical University,1 Xinsi Road, Qiaoba, Shaanxi 710038, Xi'an, China. E-mail address: [email protected] (X. Yan). Supplemental Digital Content is available for this article. Direct URL citations are provided in the HTML and PDF versions of this article on the journal's website, www.journal-surgery.net. Published online ■ ■ This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.http://creativecommons.org/licenses/by-nc-sa/4.0/
Methods, Complications, and Outcomes in a Randomized Clinical Trial of Electroacupuncture After Colorectal Cancer Surgery
Authors: Chien-Ming Yen, Tieh-Cheng Fu, Ching-Mao Chang
Journal: JAMA Surgery (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Efficacy of Roflumilast Foam, 0.3%, in Patients With Seborrheic Dermatitis
Authors: Matthew J. Zirwas, Zoe D. Draelos, Janet DuBois, Leon H. Kircik, Angela Y. Moore, Linda Stein Gold, Javier Alonso-Llamazares, Michael Bukhalo, Suzanne Bruce, Kimmie Eads, Lawrence J. Green, Scott T. Guenthner, Laura K. Ferris, Seth B. Forman, Steven E. Kempers, Edward Lain, Charles W. Lynde, David M. Pariser, Darryl P. Toth, Paul S. Yamauchi, Robert C. Higham, David Krupa, Patrick Burnett, David R. Berk
Journal: JAMA Dermatology (2023)

Current topical treatment options for seborrheic dermatitis are limited by efficacy and/or safety.To assess safety and efficacy of roflumilast foam, 0.3%, in adult patients with seborrheic dermatitis affecting the scalp, face, and/or trunk.This multicenter (24 sites in the US and Canada) phase 2a, parallel group, double-blind, vehicle-controlled clinical trial was conducted between November 12, 2019, and August 21, 2020. Participants were adult (aged ≥18 years) patients with a clinical diagnosis of seborrheic dermatitis for a 3-month or longer duration and Investigator Global Assessment (IGA) score of 3 or greater (at least moderate), affecting 20% or less body surface area, including scalp, face, trunk, and/or intertriginous areas. Data analysis was performed from September to October 2020.Once-daily roflumilast foam, 0.3% (n = 154), or vehicle foam (n = 72) for 8 weeks.The main outcome was IGA success, defined as achievement of IGA score of clear or almost clear plus 2-grade improvement from baseline, at week 8. Secondary outcomes included IGA success at weeks 2 and 4; achievement of erythema score of 0 or 1 plus 2-grade improvement from baseline at weeks 2, 4, and 8; achievement of scaling score of 0 or 1 plus 2-grade improvement from baseline at weeks 2, 4, and 8; change in Worst Itch Numeric Rating Scale (WI-NRS) score from baseline; and WI-NRS success, defined as achievement of 4-point or greater WI-NRS score improvement in patients with baseline WI-NRS score of 4 or greater. Safety and tolerability were also assessed.A total of 226 patients (mean [SD] age, 44.9 [16.8] years; 116 men, 110 women) were randomized to roflumilast foam (n = 154) or vehicle foam (n = 72). At week 8, 104 (73.8%) roflumilast-treated patients achieved IGA success compared with 27 (40.9%) in the vehicle group (P < .001). Roflumilast-treated patients had statistically significantly higher rates of IGA success vs vehicle at week 2, the first time point assessed. Mean (SD) reductions (improvements) on the WI-NRS at week 8 were 59.3% (52.5%) vs 36.6% (42.2%) in the roflumilast and vehicle groups, respectively (P < .001). Roflumilast was well tolerated, with the rate of adverse events similar to that of the vehicle foam.The results from this phase 2a randomized clinical trial of once-daily roflumilast foam, 0.3%, demonstrated favorable efficacy, safety, and local tolerability in the treatment of erythema, scaling, and itch caused by seborrheic dermatitis, supporting further investigation as a nonsteroidal topical treatment.ClinicalTrials.gov Identifier: NCT04091646.
Levels of Arsenic, Cadmium, and Mercury in Urine of Indigenous People Living Close to Oil Extraction Areas in the Peruvian Amazon
Authors: Cristina O’Callaghan-Gordo, Jaime Rosales, Pilar Lizárraga, Frederica Barclay, Tami Okamoto, Diana M. Papoulias, Ana Espinosa, Martí Orta-Martinez, Manolis Kogevinas, John Astete
Journal: Environmental Health Perspectives (2023)
Reappraisal of Idiopathic CD4 Lymphocytopenia at 30 Years
Authors: Andrea Lisco, Ana M. Ortega-Villa, Harry Mystakelis, Megan V. Anderson, Allyson Mateja, Elizabeth Laidlaw, Maura Manion, Gregg Roby, Jeanette Higgins, Safia Kuriakose, Magdalena A. Walkiewicz, Morgan Similuk, Jennifer W. Leiding, Alexandra F. Freeman, Virginia Sheikh, Irini Sereti
Journal: New England Journal of Medicine (2023)

Idiopathic CD4 lymphocytopenia (ICL) is a clinical syndrome that is defined by CD4 lymphopenia of less than 300 cells per cubic millimeter in the absence of any primary or acquired cause of immunodeficiency. Some 30 years after its original identification, ICL has remained a disease of obscure cause, with limited evidence with respect to its prognosis or management, despite diagnostic and therapeutic innovations. We evaluated the clinical, genetic, immunologic, and prognostic characteristics of 108 patients who were enrolled during an 11-year period. We performed whole-exome and targeted gene sequencing to identify genetic causes of lymphopenia. We also performed longitudinal linear mixed-model analyses of T-cell count trajectories and evaluated predictors of clinical events, the response to immunization against coronavirus disease 2019 (Covid-19), and mortality. After the exclusion of patients with genetic and acquired causes of CD4 lymphopenia, the study population included 91 patients with ICL during 374 person-years of follow-up. The median CD4+ T-cell count among the patients was 80 cells per cubic millimeter. The most prevalent opportunistic infections were diseases related to human papillomavirus (in 29%), cryptococcosis (in 24%), molluscum contagiosum (in 9%), and nontuberculous mycobacterial diseases (in 5%). A reduced CD4 count (<100 cells per cubic millimeter), as compared with a CD4 count of 101 to 300 cells, was associated with a higher risk of opportunistic infection (odds ratio, 5.3; 95% confidence interval [CI], 2.8 to 10.7) and invasive cancer (odds ratio, 2.1; 95% CI, 1.1 to 4.3) and a lower risk of autoimmunity (odds ratio, 0.5; 95% CI, 0.2 to 0.9). The risk of death was similar to that in the age- and sex-adjusted general population, but the prevalence of cancer was higher. Among the study patients, ICL continued to be associated with increased susceptibility to viral, encapsulated fungal, and mycobacterial diseases, as well as with a reduced response to novel antigens and an increased risk of cancer. (Funded by the National Institute of Allergy and Infectious Diseases and the National Cancer Institute; ClinicalTrials.gov number, NCT00867269.)
A Rare Subset of Primary Tumor Cells with Concomitant Hyperactivation of Extracellular Matrix Remodeling and dsRNA-IFN1 Signaling Metastasizes in Breast Cancer
Authors: Niccolò Roda, Andrea Cossa, Roman Hillje, Andrea Tirelli, Federica Ruscitto, Stefano Cheloni, Chiara Priami, Alberto Dalmasso, Valentina Gambino, Giada Blandano, Andrea Polazzi, Paolo Falvo, Elena Gatti, Luca Mazzarella, Lucilla Luzi, Enrica Migliaccio, Pier Giuseppe Pelicci
Journal: Cancer Research (2023)

Abstract Metastatic breast cancer has a poor prognosis and is largely considered incurable. A better understanding of the molecular determinants of breast cancer metastasis could facilitate development of improved prevention and treatment strategies. We used lentiviral barcoding coupled to single-cell RNA sequencing to trace clonal and transcriptional evolution during breast cancer metastasis and showed that metastases derive from rare prometastatic clones that are underrepresented in primary tumors. Both low clonal fitness and high metastatic potential were independent of clonal origin. Differential expression and classification analyses revealed that the prometastatic phenotype was acquired by rare cells characterized by the concomitant hyperactivation of extracellular matrix remodeling and dsRNA-IFN signaling pathways. Notably, genetic silencing of key genes in these pathways (KCNQ1OT1 or IFI6, respectively) significantly impaired migration in vitro and metastasis in vivo, with marginal effects on cell proliferation and tumor growth. Gene expression signatures derived from the identified prometastatic genes predict metastatic progression in patients with breast cancer, independently of known prognostic factors. This study elucidates previously unknown mechanisms of breast cancer metastasis and provides prognostic predictors and therapeutic targets for metastasis prevention. Significance: Transcriptional lineage tracing coupled with single-cell transcriptomics defined the transcriptional programs underlying metastatic progression in breast cancer, identifying prognostic signatures and prevention strategies.
A Critical Role for ERO1α in Arterial Thrombosis and Ischemic Stroke
Authors: Vishwanath Jha, Bei Xiong, Tripti Kumari, Gavriel Brown, Jinzhi Wang, Kyungho Kim, Jingu Lee, Nathan Asquith, John Gallagher, Lillian Asherman, Taylor Lambert, Yanyan Bai, Xiaoping Du, Jeong-Ki Min, Rajan Sah, Ali Javaheri, Babak Razani, Jin-Moo Lee, Joseph E. Italiano, Jaehyung Cho
Journal: Circulation Research (2023)

Platelet adhesion and aggregation play a crucial role in arterial thrombosis and ischemic stroke. Here, we identify platelet ERO1α (endoplasmic reticulum oxidoreductase 1α) as a novel regulator of Ca
A comment on hemihepatic versus total hepatic inflow occlusion for laparoscopic hepatectomy: a randomized controlled trial
Authors: Chang Diao, Xiaoping Wei
Journal: International Journal of Surgery (2023)

aDepartment of general surgery, the first affiliated hospital of Kunming Medical University, Kunming, Yunnan, China bDepartment of HPB surgery, the second affiliated hospital of Kunming Medical University, Kunming, Yunnan, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of HPB surgery The second affiliated hospital of Kunming Medical University 374 Burma Road, Kunming, Yunnan,China, 650101, Fax:86 87165351281, Phone: 86 13888990023. E-mail address: [email protected] (X. Wei). This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-nc-sa/4.0/
Buried dermal interrupted or vertical mattress suture: which is the best for dermal layer suturing of surgical skin wounds?
Authors: Suman Patra, Thoyiib Paramal Karat, Maninder Kaur
Journal: British Journal of Dermatology (2023)

Dermatosurgery being a field involving personal approaches in dealing with various problems has wide differences in choice of suture, suturing methods while closing a wound in different groups. It is therefore important to know pros and cons of various suturing techniques for one of the most important suture for wound closure i.e subcuticular dermal sutures.