tbuckley/cabot-search huggingface dataset:
Normal ECG in Patients With Severe Coronary Artery Disease
Authors: Andrew J. Doorey
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sickle Cell Trait and Sudden Death in Athletes
Authors: Karen K. Kerle
Journal: JAMA (1996)

<h3>To the Editor.</h3> —In their timely study on sudden death in athletes, Dr Maron and colleagues<sup>1</sup>highlight hypertrophic cardiomyopathy as the major cause of sudden death in athletes younger than 35 years. However, we are concerned that the association between sudden death and sickle cell trait<sup>2</sup>has not been adequately addressed in this article. The authors briefly mention 1 case of sudden death due to sickle cell trait. However, it is unclear how many of the 58 other black athletes in the series were sickle trait positive and how many were tested for the presence of hemoglobin AS. Because the association between sickle cell trait and sudden death is not widely appreciated, sickle cell trait may have been overlooked as an etiologic factor in the sudden death of several of these athletes. The prevalence of sickle cell trait is known to be 8% in the black population.<sup>3</sup>
The Influence of Growth on Congenital and Acquired Deformities.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physiology and Biochemistry in Modern Medicine.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Brucellosis (Undulant Fever); Clinical and Subclinical.
Journal: Annals of Internal Medicine (1942)

1 and more effective preparations without any critical discussion to indicate relative values.The physician without spe- cial training or experience could well be led astray.An extensive bibliography is given at the end of each chapter, but unfortunately a few errors are apparent.The discussion on antithyroid substainces is principally on thiouracil.Very little space is given to propylthiouracil which is now acknowledged to be considerably safer and more effective and is much more generally used.The data that are given seem to have been added as an afterthought.The recent work on ACTH and Compound E in arthritis and other diseases is not mentioned.In general, the book is interesting reading for an endo- crinologist and would be an addition to the library of anyone particularly interested in this field.Its value to the prac- ticing physician without training and experience in endo- crinology is doubtful.
Water-Soluble, Dextran-Linked Retinal: Preparation, Vitamin?-Like Activity in Rats, and Effects on Melanoma Cells&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1980)

A new, water-soluble, polymer-linked form of retinal was synthesized and tested for its ability to support the growth of vitamin?-deficient noninbred Holtzman rats and to inhibit the proliferation of melanoma cells in culture. Retinal was conjugated to the hydrazide of carboxymethyldextran in the presence of α-and β-cyclodextrins. The aqueous solutions of the product contained between 200 and 1,000 μg retinal/ml as opposed to the low water solubility (<0.01 μg/ml) of retinal itself. The retinal-dextran complex, although barely resorbed from the gastrointestinal tract, supported the growth of rats fed a vitamin A-deficient diet when administered ip at 2.3 μ mol of retinal equivalent/kg body weight. Retinal and the retinal-dextran complex exhibited differential cytotoxicity toward S91 melanoma cells and caused cell lysis at 10 and 500 μ? (retinal residue), respectively. At noncytotoxic doses both free retinal and its dextran-linked derivative reduced the cell proliferation rate in a time- and dose-dependent fashion with median inhibitory doses of 1 and 4 μ? (retinal residue), respectively. These data demonstrated that the water-soluble retinal-dextran complex retained certain biologic activities of retinal and was less cytotoxic.
Abstract 1355: Determining Wavefront Size during Ventricular Fibrillation: Optical Mapping Study from Human Langendorff Hearts
Authors: Stephane Masse, John Asta, Elias Sevaptsidis, Robert Cusimano, Terry Yau, Heather Ross, Vivek Rao, Rajesh Dhopeshwarkar, Kumar Nanthakumar
Journal: Circulation (2007)

Background: We had recently established a model for the study of VF in humans using an optical mapping technique in Langendorff perfused human hearts. The optical mapping technique allows for the unequivocal evaluation of wavefront identification, the origin of wavefronts and their directional spread. Objective: The objective of this study was to measure wavefront sizes from different regions during human VF to determine the minimal spatial resolution required to study human VF in-vitro. Methods: The hearts were explanted from seven cardiomyopathic patients who underwent transplantation. The hearts were Langendorff perfused with Tyrode’s solution (95%O 2 +5%CO 2 ) and the potentiometric dye (0.2 mg Di-4-ANEPPS dissolved in 20mg of perfusate) was injected as a bolus into the coronary circulation. The imaged region was physically immobilized to minimize motion. The fluorescence was excited at 530 nm with a HL 150 W halogen lamp, the emission signal was longpass filtered at 610 nm and recorded with a CCD and CMOS camera (MiCAM02, Ultima, BrainVision Inc., Japan). The spatial resolution depending on the mapping window was 0.65–0.85 mm and the temporal resolution was 1 kHz. The heart was paced at a cycle length of 600 ms and the VF was induced by briefly touching the heart with the two poles of a 9V battery. The changes in dye signal were recorded over 1887 ms and analyzed using BV-analyzer software (BrainVision Inc, Japan). Wavefronts were identified using high-pass filter (0.01 Hz) on the fluorescence data. Recordings were performed at 4 sites: LV Septum (LVS), Right Ventricle Endocardium (RV), Left Ventricle Endocardium (LVendo) and Left Ventricle Epicardium (LVepi). Results: 16 episodes of VF were recorded and a total of 54 wavefronts were identified. Average wavefront size was 23.6 mm. By region, the average wavefront sizes were: LVS = 26.3 mm; RV = 22.4 mm; LVendo = 29.7 mm; LVepi = 19.3 mm. Conclusion: These results show that different regions on the human ventricle during VF show different wavefront size suggesting that propensity for wavebreak maybe spatially differentially distributed. To study human VF with multi-electrode mapping tools using inter-electrode spacing of less than 1–2 cm should provide sufficient resolution.
The diverse nature of cancer cells: one reason therapy can fail
Authors: Catherine Macek
Journal: JAMA (1982)

Although many cancer researchers believe that a cancer arises from a single aberrant cell, the same cancer may contain a diverse population of cells when it reaches a clinically detectable size. Recently, the implications of this heterogeneity for causes and treatment of primary cancers and metastases were discussed at a Bristol-Myers Symposium on Cancer Research held at The Johns Hopkins Oncology Center, Baltimore. "It is becoming apparent that tumor cells which look alike when stained and viewed under the microscope do not necessarily behave alike in the body," said Albert H. Owens, Jr, MD, head of the center and symposium director. "For example, some may metastasize while others won't; some may divide, others not; some may be sensitive to drugs, others resistant." According to Stephen B. Baylin, MD, associate professor of oncology and medicine at Johns Hopkins, it is possible to correlate the prognosis of patients having medullary thyroid cancer
A Graphic Guide to Elementary Surgery.
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A difficult case: Management of metastatic melanoma during pregnancy Commentary: Pregnancy should not have affected treatment for melanoma Commentary: Self interest is not the sole legitimate basis for making decisions Commentary: Management of the patient
Authors: S R D Johnston, K Broadley, G Henson, C Fisher, M Henk, M E Gore, R. Hammond, C. Weijer, S R D Johnston, K Broadley, G Henson, C Fisher, M Henk, M E Gore
Journal: BMJ (1998)
The Case for Using Industrial Quality Management Science in Health Care Organizations
Authors: Glenn Laffel
Journal: JAMA (1989)

In an effort to provide health care of optimal quality, providers traditionally assess or measure performance and then assure that it conforms to standards. In cases where performance fails to conform, providers attempt to modify or improve physician behavior. The analytic scope of this traditional paradigm may not be broad enough to allow modern health care organizations to provide optimal care. At a theoretical and practical level, many conceptual limitations inherent in the traditional approach are addressed in modern industrial quality science. A fundamental principle of industrial quality control is the recognition, analysis, and elimination of variation. Based on rigorous analysis of variation in outcomes and processes, industrial quality experts have developed principles and techniques for quality improvement. Health care organizations may well make important advances in the quality of care and service through the application of these principles and techniques. (<i>JAMA</i>. 1989;262:2869-2873)
Injuries of the Wrist: A Radiological Study.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Объективизация тревожно-депрессивных расстройств и обоснование назначения их коррекции у больных гастроэнтерологического профиля
Authors: S.V. Kosinskaya
Journal: GASTROENTEROLOGY (2013)

Статья посвящена проблеме тревожно-депрессивных расстройств у больных со стойкой гастроэнтерологической симптоматикой. По шкале HADS средний уровень тревоги у обследованных пациентов составил (11,20 ± 3,03), что соответствует клинически выраженной категории, а по шкале депрессии (9,20 ± 3,61) — субклинической. Персональную высокую тревожность имели 62,5 %, а реактивную высокую тревожность — 65,6 % больных. Объективизация тревожно-депрессивных расстройств позволяет обоснованно подходить к выбору терапии.
Clinical Diagnosis of Moles vs Melanoma
Authors: Robert A. Swerlick
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serosurveys for West Nile Virus Infection—New York and Connecticut Counties, 2000
Journal: JAMA (2001)

In 2000, 21 persons were reported with acute illness attributed to West Nile virus (WNV) infection; 19 were hospitalized with encephalitis or meningitis. Of the 21, 10 resided in the Staten Island borough (Richmond County) of New York City. Other ill persons resided in nine other counties--Kings (Brooklyn), New York (Manhattan), and Queens counties in New York; Hudson, Passaic, Monmouth, Morris, and Bergen counties in New Jersey; and Fairfield County in Connecticut. Because ill persons represent only a fraction of the persons who are infected, many more persons probably were infected in 2000. To determine the prevalence of recently acquired WNV infection and associated risk factors for infection, random household cluster serosurveys were conducted in Staten Island and portions of Fairfield County, Connecticut, and Suffolk County, New York, during October-November 2000. All three areas had intense WNV epizootics as determined by avian mortality and mosquito surveillance systems. This report summarizes the preliminary results of this survey and indicates that in areas with intense epizootic WNV activity, asymptomatic or mildly symptomatic human infections can occur.
Highlights of This Issue
Journal: Clinical Cancer Research (2010)

Aerodigestive tract cancer (e.g., carcinomas of lung and esophagus) is one of the most common malignancies in the world. Here, Sato and colleagues identify the cancer-testis antigen WD repeat and HMG-box DNA-binding protein 1 (WDHD1) as a prognostic biomarker for lung and esophageal cancer. Further, they show that WDHD1 is phosphorylated by AKT1 kinase, providing evidence for a possible role of WDHD1 in carcinogenesis. The results here suggest that selective inhibition of WDHD1 expression and/or targeting the enzymatic interaction between AKT1 and WDHD1 could be a promising therapeutic strategy for treatment of aerodigestive tract cancer.Alterations inDNA methylation are common in colorectal carcinogenesis. To comprehensively study DNAmethylation epigenotypes in colorectal cancer, Yagi and colleagues performed genome-wide analyses ofDNA methylation and expression and identified newmethylationmarkers. Clustering of clinical colorectal cancer samples showed three distinctmethylation epigenotypes: high-methylation, intermediatemethylation, and low-methylation. The authors found that the high-methylation epigenotype correlated stronglywith BRAF-mutation status and that the intermediatemethylation epigenotype correlated strongly with KRAS-mutation status. Further, the intermediate-methylation epigenotypewith KRAS-mutation status correlatedwithworse prognosis. Themarkers developed heremay have clinical applicability in predicting survival of patientswith colorectal cancer.Etoposide is widely used for treatment of different malignant neoplasms, but its use is also associated with serious adverse reactions, including leukopenia, thrombocytopenia, and gastrointestinal toxicity. Using a mouse model, Lagas and colleagues show here that the multidrug transporters P-glycoprotein, ABCC2, and ABCC3 determine the pharmacokinetics of etoposide. Therefore, mutations affecting the expression and/or function of these transporters could result in increased toxicity. However, they also show that P-glycoprotein, ABCC2, and ABCC3 have substantially overlapping functions in the elimination of etoposide, suggesting that patients may be relatively protected from toxicity when just one of these transporters shows reduced expression or function.The secondary T790M mutation in EGFR is the most frequent cause of acquired resistance to reversible EGFR tyrosine kinase inhibitors (EGFR-TKI) in lung cancer and irreversible EGFRTKIs are potentially useful to overcome resistance to reversible EGFR-TKIs. Here, Yamada and colleagues investigated the development of resistance to irreversible EGFR-TKIs in lung cancer. They show that hepatocyte growth factor (HGF) could reduce susceptibility to an irreversible EGFRTKI in lung cancer cells with the secondary T790M mutation in EGFR. Further, they found that inhibitors of HGF-MET could restore sensitivity to the irreversible EGFR-TKI. These findings provide insight into the involvement of HGF-MET-mediated signaling in acquired resistance to irreversible EGFR-TKIs in lung cancer.
Graft-Versus-Host Reaction Modified by &lt;italic&gt;In Vitro&lt;/italic&gt; Preincubation of Marrow With Subcellular Antigen
Authors: Delta E. Uphoff, Laurence R. Draper
Journal: JNCI Journal of the National Cancer Institute (1971)

The graft-versus-host reaction induced by inoculation of AKR marrow into lethally irradiated (AKR × CBA)F1 and (CBA × AKR)F1 hybrid recipients was prevented by the in vitro preincubation of AKR marrow with stromata of CBA erythrocytes for 35 minutes at 26°C. This subcellular antigen was as effective as, or more effective than, fresh preparations of intact erythrocytes. This validated the assumption that the critical factor in the incubation procedure was contact with tissue antigens rather than transfer to the recipient of viable stem cell contaminants in the erythrocyte preparation.
Antigenic Characterization of Heterozygous Mouse Lymphomas After Immunoselection &lt;italic&gt;In Vivo&lt;/italic&gt;&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Bjaring, Bertil, Klein, George
Journal: JNCI Journal of the National Cancer Institute (1968)

Journal Article Antigenic Characterization of Heterozygous Mouse Lymphomas After Immunoselection In Vivo Get access Bertil Bjaring, Bertil Bjaring Department of Tumor Biology, Karolinska Institutet, Stockholm, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar George Klein George Klein Department of Tumor Biology, Karolinska Institutet, Stockholm, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 41, Issue 6, December 1968, Pages 1411–1429, https://doi.org/10.1093/jnci/41.6.1411 Published: 01 December 1968 Article history Received: 26 July 1968 Accepted: 03 September 1968 Published: 01 December 1968