tbuckley/cabot-search huggingface dataset:
Biological Problems of Death
Journal: JAMA (2018)

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Obituary
Authors: Diane Iselin
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL CRISIS IN CHINA: THE FIELD FOR MEDICINE IN THE ORIENT.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Changes in sulfated proteoglycan production after activation of rat liver macrophages
Authors: J Laskin
Journal: Hepatology (1991)

Production of extracellular matrix proteins — in particular, the proteoglycans-by macrophages is important in many of their functions, including cell-cell recognition, adhesion and phagocytosis. In this study, we characterized changes in sulfated proteoglycan production by hepatic macrophages following in vivo activation with lipopolysaccharide. We found that both resident Kupffer cells and liver macrophages from lipopolysaccharide-treated rats incorporated [35S]sulfate into proteoglycans. Lipopolysaccharide-activated macrophages incorporated two to three times more of the label than did resident Kupffer cells. In addition, although both cell types produced chondroitin sulfate and heparan sulfate, resident Kupffer cells synthesized more chondroitin sulfate whereas lipopolysaccharideactivated cells produced more heparan sulfate. Using specific antibodies and flow cytometry, we also found that hepatic macrophages produced chondroitin-4-sulfate, chondroitin-6-sulfate and chondroitin-O-sulfate. Lipopolysaccharide-activated macrophages contained more chondroitin-4-sulfate and chondroitin-O-sulfate and less heparan sulfate than did resident Kupffer cells. Both tunicamycin and β-D-xylosides, inhibitors of sulfated proteoglycan biosynthesis, were found to block phagocytosis by the cells. Taken together, these results suggest that sulfated proteoglycans are important in activation and functional responsiveness of liver macrophages. (HEPATOLOGY 1991;14:306–312.)
Mesovarian Leiomyomas in the Rat
Authors: C. Gopinath, W. A. Gibson
Journal: Environmental Health Perspectives (1987)

Prolonged treatment with two chemically distinct beta-stimulants, Salbutamol and Terbutaline, resulted in mesovarian leiomyomas in Sprague-Dawley rats. Development of these tumors induced by Salbutamol was prevented by concurrent administration of the beta-blocker Propranolol. Mesovarian leiomyomas induced by Salbutomol did not show any regression or progression during a 44-week postdosing recovery period. This report also gives the first recorded incidence of spontaneous mesovarian leiomyomas in the rat.
Military and Naval Medical Services
Journal: BMJ (1882)

be worked consistently with the advance which has been made in medi- cal science, and with the change of opinion which is taking place re- garding the administration of medical charity. 6.That it is desirable to make more use than is at present made, in the education of medical students, of the materials contained in the numerous hospitals and dis- pensaries nowv administered bv the Poor-law Department and the AMetropolitan Asylums, Board; and that there should be more intimate communication between these and the general hospitals.7.That the operation and constituition of the numerous special hospitals and dis- pensaries demand inqutiry, in order to inform the public as to the ad- vantages and disadvantages of such institutions.8.That it is desirable that an uniform system should be devised and adopted of keeping the bocl;s of accounts and registers of disease in all hospitals."TIIE PLAISTOW HOSPITAL FOR SMALL-POX PATIENTS.TIlE first annud.1 report of this hospital has recently appeared.The institution was opene(l for the reception of patients in Mlay iS8i.Since that date, i2o cases have been admitted.Of these, 5 were sent by the City of Lonidon Union, 6 by the Vestry of Bethnal Green, 8 by the Poplar Union, an(l the remainder from the Poplar district; II2 were (lischarged cured, and S died.The severe and fatal cases occurred amongst the unvaccinated, or those whose marks were slight and un- satisfactory.Of the 37 confluent cases, 8 proved fatal-4 females and 4 males.The hospital is said to be in perfect condition, and the staff fulfil their duties in a .atisfactorymanner. BEDFOIRD PJROVIDENT DISPENSARY.TIlE report of this inistitution for I88i gives so little information, that it is difficult to fornm an estimate of the position of the dispensary.Thus, we are not tokl how many members there are on the books, or how many visits were pai(d by the medical officers.Indeed, the report is occupied much more with the honorary subscribers than it is with the Frovi(lent members.It appears, from the balance sheet, that /571 were (livided among the six medical officers.KENT AND CANTERBURY HOSPITAL.TilE annual meeting of this institution was recently held, and it was shown that the general condition of the hospital was satisfactory.It was suggested, however, that, in future, the medical staff should present an annlial summary of the cases that had passed under their hands, together with such particulars as might have a bearing upon the sanitary condition or expenditure of the hospital.But the most important ques- tion raised at the meeting related to the application of 'Mrs.Goreley's bequest.During the past year, the dividends arising from this source were carried to the general fund; but the opinion of the governors seemed to be that the bequiest should be applied to some specific pur- pose, which would be a permanent improvement to the hospital, such as the erection of a children's ward.
Nonchromosomal Heredity
Authors: Ruth Sager
Journal: New England Journal of Medicine (1964)

SOME applications of the science of genetics to the practice of medicine were clearly stated in 1908 by the English physician, Garrod,1 in his now famous book, Inborn Errors of Metabolism. Garrod had been impressed by the case histories of patients with alcaptonuria, cystinuria and certain other congenital diseases. In his book he proposed that these diseases were each the result of a gene mutation leading to an altered metabolic pathway. He anticipated in an impressive manner the subsequent evidence and thinking that led Beadle and Tatum to propose in 1941 the "one gene one enzyme" hypothesis: that single . . .
Attractive method for battery removal
Authors: G. L. Landry
Journal: JAMA (1986)

<h3>To the Editor.—</h3> We appreciated the article by Kavanagh and Litovitz<sup>1</sup>entitled "Miniature Battery Foreign Bodies in Auditory and Nasal Cavities." We would like to add the use of a magnet to the list of possible battery retrieval methods. Use of a magnet to remove batteries from the stomach has been described,<sup>2</sup>but, to our knowledge, a magnet has not been used for removal of batteries from other orifices. A magnetized screwdriver worked very well in the following case. <h3>Report of a Case.—</h3> A 9-year-old girl awoke with acute otalgia in the left ear immediately after her 5-year-old play-mate inserted a miniature toy watch battery in her ear canal. Her intense pain continued and she was examined in our clinic about 90 minutes after the incident. The battery was lodged mid-way in the canal and efforts to retrieve the battery with alligator forceps were unsuccessful and painful. After
THE NIGHT CAMP FOR TUBERCULOUS PATIENTS.
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Example of prepublication data release: immunoglobulin for concomitant infections
Authors: C. Marwick
Journal: JAMA (1991)

INTRAVENOUS injection of a broad-spectrum immunoglobulin significantly reduces the number of bacterial infections in some children who are infected with the human immunodeficiency virus (HIV). It also significantly increases the time patients are free of infection and reduces the number of hospitalizations. These are the results of a double-blind, placebo-controlled study by the National Institute of Child Health and Human Development, Bethesda, Md. However, despite these findings, there was no effect on mortality. Thirty-one patients died in each of the two groups studied. The treatment is not a cure for pediatric acquired immunodeficiency syndrome (AIDS). The institute's parent, the National Institutes of Health, released the results prior to publication in a scientific journal, says the acting director, William Raub, PhD, in accordance with a proposed new system. (Please see related article on page 949.) "We believe these results have the prospect for an immediate and positive effect on the treatment
Book Review Anatomo-Clinical Diagnostics . By Paul Lecène. II. Female Reproductive System, Part I. (Les Diagnostics Anatomo-Cliniques de P. Lecène. II. Appareil Génital de la Femme. First Part.) By P. Moulonquet and S. Dobkevitch. Paris, Masson et Cie. 1931. Price 75 fr.
Journal: New England Journal of Medicine (1931)
Detection of HTLV-III RNA in lungs of patients with AIDS and pulmonary involvement
Authors: K. J. Chayt
Journal: JAMA (1986)

A majority of pediatric patients and rare adult patients with the acquired immunodeficiency syndrome (AIDS) develop a chronic respiratory disorder referred to as "lymphocytic interstitial pneumonitis" (LIP). Efforts to identify an infectious agent responsible for this process so far have failed. In this study, frozen sections of lungs from patients with AIDS and pulmonary disease were tested by in situ molecular hybridization for the presence of cells infected with human T-cell lymphotropic virus type III (HTLV-III) and expressing viral RNA. In the case of an infant with LIP, a relatively high frequency (0.1 %) of cells in the lung were found to be positive for HTLV-III RNA. This number is the lower limit of total cells infected since the in situ hybridization technique as applied in this study depends on expression of HTLV-III genes, and previous evidence indicates that a proportion of cells infected with HTLV-III may not express viral RNA. Moreover, this degree of infection of the lung is likely limited to LIP, since in ten patients with AIDS and pulmonary diseases other than LIP, only 0% to 0.002% of cells in lung were positive for viral RNA expression. Thus, HTLV-III may play a direct causal role in the development of LIP in infected patients, implicating its involvement in yet another of the diverse clinical diseases associated with this virus. (<i>JAMA</i>1986;256:2356-2359)
Palliative Care
Authors: Keith M. Swetz, Arif H. Kamal
Journal: Annals of Internal Medicine (2018)

Palliative care prioritizes symptom management and quality of life throughout the course of serious illness. Regardless of whether care is inpatient or outpatient, primary or subspecialty, a solid understanding of the basics of effective communication, symptom management, and end-of-life care is crucial. This article reviews these essentials and provides an overview of current evidence to support patient-centered palliative care.
Acute Brain Damage Induced by X-Irradiation With Special Reference to Rate and Recovery Factors
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pseudosarcomatous dermatofibroma
Authors: P.B. THAVABALAN, V.T. RATNAIKE
Journal: British Journal of Dermatology (2006)

A pseudosarcomatous dermatofibroma with marked collagen damage is reported. The multinucleated giant cells and proliferation of very elongated sarcomatous‐like fibroblasts histologically resemble a highly malignant sarcoma.
Gallbladder symptoms and the roentgenographically normal gallbladder
Authors: E. D. Palmer
Journal: JAMA (1974)

AMONG the common abdominal diseases, cholecystitis, acute and chronic, has the reputation as the easiest to recognize on the basis of history and physical examination. Prior to objective studies, the clinician is likely to feel more confident about his working diagnosis of gallbladder disease than that of such problems as gastric or duodenal ulcer, cecal carcinoma, small bowel inflammatory disease, and others. Furthermore, it can be agreed that cholecystography is one of the most reliable of the radiologic diagnostic techniques used for investigation of abdominal complaints. Nevertheless, it is not rare for the clinician to find that the<i>cholecystogram is normal</i>in the patient who, he is certain, has the historical and physical findings that indicate gallbladder disease. <h3>Normal Cholecystogram</h3> When this happens, can the clinician choose his bedside opinion over the radiologist's? Can he decide on cholecystectomy, perhaps assuming cholesterosis or biliary mud or simply some more common gallbladder
Table of Contents
Authors: Mercedes Rigla, Ana Wägner, Montserrat Borrell, José Mateo, Jordi Foncuberta, Alberto De Leiva, Jordi Ordóñez-Llanos, Antonio Pérez, Jörgen Nordenström, Anders Thörne, Wiveca Åberg, Claes Carneheim, Thomas Olivecrona, Franco Fallucca, Maria Dalfrà, Ernesta Sciullo, Michela Masin, Angela Buongiorno, Angela Napoli, Domenico Fedele, Annunziata Lapolla, Melissa Moreira Zanquetta, Monalisa Cabral Nascimento, Rosana Cristina, Tieko Mori, Beatriz D', Agord Schaan, Martin Young, Ubiratan Fabres Machado, Jee-Aee Im, Sang-Hwan Kim, Ji-Won Lee, Jae-Yong Shim, Hye-Ree Lee, Duk-Chul Lee, Dharmendrakumar Patel, Sathanur Srinivasan, Ji-Hua Xu, Wei Chen, Gerald Berenson
Journal: Metabolism (2006)
Authors’ response
Authors: Ian Pavord, Peter G Gibson
Journal: Thorax (2012)

We thank Fleming and Bush for their comments 1 on our editorial 2 .We accept that there is no good evidence of a dose-response relationship against eosinophilic airway inflammation with higher dose inhaled steroids in children with asthma.We also recognise that it might be difficult to justify high dose inhaled corticosteroids, or treatment with regular oral corticosteroids in a child with few symptoms.However, the fact remains the principle of sputum based inflammation monitoring has not been tested by this study, 3 yet the paper is being presented as a test of that process.In this respect, the manuscript is similar to that of Szefler et al 4 where a serious design limitation also prevented optimal assessment of the technique.
Donor transaminase and recipient hepatitis. Impact on blood transfusion services
Authors: H. J. Alter
Journal: JAMA (1981)

To assess the relationship of donor alanine aminotransferase (ALT) level to recipient hepatitis, 283 transfused patients were prospectively followed up after open heart surgery; hepatitis developed in 12.7%, of which 97% was non-A, non-B. The ALT tests on 3,359 donors to these patients indicated that risk of hepatitis was significantly associated with the level of donor ALT; 29% of 52 patients receiving at least 1 unit of blood with an ALT level greater than 53 IU/L had hepatitis develop (20.7 cases per 1,000 units), compared with 9% of 231 recipients of only blood with an ALT level of 53 IU/L or less (7.8 cases per 1,000 units). Calculation of corrected efficacy predicts that, at an exclusion level equivalent to 2.25 SDs above the mean log for normal subjects, ALT testing of donors could prevent 29% of posttransfusion hepatitis at the loss of 1.6% of donor units. (<i>JAMA</i>1981;246:630-634)
JOHN FREKE (1688-1756)— SURGEON AND MAN OF LONDON
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal