tbuckley/cabot-search huggingface dataset:
A Surgeon's Guide to Local Anæsthesia: A Manual of Shockless Surgery
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Arterial Anticancer Drug Infusion Therapy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The value of dynamic hepatic scintigraphy and serum aminoterminal propeptide of type III procollagen for early detection of methotrexate-induced hepatic damage in psoriasis patients
Authors: R. J. VANDOOREN-GREEBE, A. L. A. KUIJPERS, W. C. A. M. BUIJS, P. H. M. KNIEST, F. H. M. CORSTENS, F. M. NAGENGASTS, Th. BOO, J. L. WILLEMS, P. DULLER, P. C. M. KERKHOF
Journal: British Journal of Dermatology (1996)

Oral m ethotrexate (MTX) is a highly effective drug for the treatment of severe psoriasis.A limitation of this treatm ent is its potential hepatotoxicity.In the present prospective study the value of dynamic hepatic scintigraphy (DHS) and serum am inoterm inal propeptide of type III procollagen (PIIINP) were investigated as screening m ethods for early detection of MTX-induced hepatic damage.These relatively non-invasive procedures were compared with the liver biopsy classification, until now the gold standard to assess MTX-induced liver damage.Twenty-five MTX patients were studied.The mean cum ulative MTX dose w as 3-9 g (range 0 -2 -1 1 * 1 g).Tw enty-one patients had a normal liver histology (grade I), three patients had steatosis (grade II), and one patient mild fibrosis (grade IIIA), Seven additional patients w ith non-MTX related hepatic cirrhosis were included as disease controls.DHS show ed a clear-cut separation between the portal contribution of the MTX patients with grade I liver histology, and that of all other patients.A portal contribution larger than 52% was associated w ith a >95% chance of normal liver histology.If this cut-off value had been used to postpone the liver biopsy, this would have resulted in at least a 55% reduction in the number of biopsies in patients with a norm al liver histology.DHS appeared to be very promising as a screening test to differentiate betw een the presence or absence of MTX-induced hepatic damage, but appeared not suitable to grade the severity of hepatic damage.Although a global relationship was demon strated between serum PIIINP concentration and hepatic dam age, single m easurem ents in indivi dual patients were not reliable.The com bination of PIIINP m easurem ents with DHS had only a limited additional value above DHS alone.The present study indicates that DHS has great promise for the detection of early MTX-induced hepatic dam age.Pending further studies, regular liver biopsies remain m andatory for the safe prolonged use of MTX in psoriasis patients.Oral methotrexate (MTX) is a highly effective drug for
Randomized, phase III study of mitomycin/vindesine/cisplatin (MVP) versus weekly irinotecan/carboplatin (IC) or weekly paclitaxel/carboplatin (PC) with concurrent thoracic radiotherapy (TRT) for unresectable stage III non-small cell lung cancer (NSCLC): WJTOG0105
Authors: M. Satouchi, N. Yamamoto, Y. Chiba, S. Kudoh, T. Hida, A. Kubo, T. Seto, Y. Nishimura, K. Nakagawa, M. Fukuoka
Journal: Journal of Clinical Oncology (2009)

7504 Background: Weekly chemotherapy with concurrent TRT displays acceptable toxicities and dependable efficacy. We conducted a randomized phase III trial to assess the efficacy and toxicity of weekly chemotherapy with concurrent TRT against MVP with concurrent TRT via a non-inferiority design. Methods: MVP: mitomycin (8 mg/m 2 on days 1, 29), vindesine (3 mg/m 2 on days 1, 8, 29, 36), and cisplatin (80 mg/m 2 on days 1, 29) with concurrent TRT (60 Gy). Patients (pts) subsequently received 2 courses of consolidation chemotherapy with MVP; IC: weekly irinotecan (20 mg/m 2 )/carboplatin (AUC 2) for 6 weeks and TRT (60 Gy) followed by 2 courses of irinotecan (50 mg/m 2 )/carboplatin (AUC 5); PC: weekly paclitaxel (40 mg/m 2 )/carboplatin (AUC 2) for 6 weeks and TRT (60 Gy) followed by 2 courses of paclitaxel (200 mg/m 2 )/carboplatin (AUC 5). The primary endpoint was overall survival (OS), with secondary endpoints of progression free survival (PFS), response, and toxicity. Results: From Sep 2001 to Sep 2005, 456 pts were randomized. Pretreatment characteristics were well-balanced among 3 arms. Major toxicity incidences: The incidence of G3–4 neutropenia in the MVP, IC, and PC arms was 95.9, 72.1, and 46.9 % (p&lt;0.001). The G3–4 non-hematologic toxicity incidences in terms of fatigue, febrile neutropenia, and gastrointestinal disorder were 13.0, 6.1, and 4.8 % (p&lt;0.001), 37.0, 8.8, and 10.2 % (p&lt;0.001), and 24.0, 8.2, and 9.5% (p&lt;0.001) in the respective arms. The overall response rates were 66.4, 56.5, and 63.3 %, in the MVP, IC and PC arms, respectively. The median survival times were 20.5, 19.8 and 22.0 months and the median PFS (MPFS), 8.2, 8.0 and 9.5 months in MVP, IC and PC. Non-inferiority of the 2 experimental arms compared with MVP was not achieved, though no significant differences in OS and PFS were apparent among treatments. The PC arm displayed the most favorable MST, MPFS, and hematologic/non-hematologic toxicities. Conclusions: Weekly PC with TRT displays similar efficacy and more favorable toxicity profiles compared to MVP with TRT. Weekly PC with TRT warrants use as the reference regimen in forthcoming studies. [Table: see text]
The 1923 Bowman Lecture. Concerning Certain Ocular Aspects of Pituitary Body Disorders, Mainly Exclusive of the Usual Central and Peripheral Hemianopic Field Defects.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOCIAL STATUS OF THE BRITISH MEDICAL PROFESSION.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PROPHYLAXIS OF SYPHILIS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Noninvasive Ventilation
Authors: Nicholas S. Hill
Journal: Annals of Internal Medicine (1994)

Letters15 December 1994Noninvasive VentilationNicholas S. Hill and Thomas MeyerNicholas S. HillSearch for more papers by this author and Thomas MeyerSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-12-199412150-00043 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Confalonieri and colleagues raise the issue of appropriate selection guidelines for the use of noninvasive positive pressure ventilation in patients with acute respiratory failure. They correctly point out that “hemodynamic instability” was not precisely defined in our review, and they report their experience with a series of patients, including some with hypotension, most of whom were successfully treated with noninvasive positive pressure ventilation. Information on the appropriate use of noninvasive positive pressure ventilation in patients with acute respiratory failure is evolving, and it is not possible to delineate precise patient selection criteria because of the lack of well-designed ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1994Volume 121, Issue 12Page: 984-985KeywordsHemodynamicsHypotensionMusclesNoninvasive ventilationParalysisPatientsPositive pressure ventilationRespiratory failureResuscitationSystolic pressure ePublished: 15 August 2000 Issue Published: 15 December 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Diagnosing Vascular Causes of Renal Failure
Authors: J. Gary Abuelo
Journal: Annals of Internal Medicine (1996)

Letters15 July 1996Diagnosing Vascular Causes of Renal FailureJ. Gary Abuelo, MDJ. Gary Abuelo, MDRhode Island Hospital, Providence, RI 02903Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-2-199607150-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Ahrens reports that he has frequently seen patients with generalized atherosclerosis and progressive renal failure whose renal biopsy results show hypertensive nephrosclerosis despite mild or no hypertension. We have also seen such patients, but other cases may be unrecognized because the patients present with gradually worsening azotemia, for which renal biopsy is usually not done. The rapid progression to end-stage renal failure reported by Dr. Ahrens is somewhat surprising but could be explained by a second process, such as cholesterol emboli or renal artery stenosis.Hypertensive or benign arteriolar nephrosclerosis is characterized by hyaline thickening of the ...References1. Heptinstall RH. Hypertension. I: Essential hypertension. In: Heptinstall RH, ed. Pathology of the Kidney. 4th ed. Boston: Little, Brown; 1992:951-1028. Google Scholar2. Kasiske BL. Relationship between vascular disease and age-associated changes in the human kidney. Kidney Int. 1987; 31:1153-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: Rhode Island Hospital, Providence, RI 02903 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 July 1996Volume 125, Issue 2Page: 155KeywordsAtherosclerosisBiopsyCholesterolHypertensionPathogenesisPathologistsRenal arteriesRenal diseasesRenal failureStenosis ePublished: 15 August 2000 Issue Published: 15 July 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
AN AUTOGRAPH HISTORY OF A CASE OF ADDISON'S DISEASE
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PAROXYSMAL TACHYCARDIA.
Authors: JOSEPH M. PATTON
Journal: JAMA (1900)

It is not my purpose to undertake a semeiological discussion of the motor disturbances of the heart, but to ask your indulgence for a few moments' consideration of one of the two alterations of the cardiac rhythm which present definite features with sufficient constancy and regularity to have brought them almost within the category of the recognized diseases of the heart, where they probably belong, yet in which the failure, so far, to define their pathologic entity has relegated them to the class of so-called functional disorders of that organ. A full consideration of the semeiotics of these disorders —tachycardia and bradycardia—would involve a discussion of the innervation of the circulatory apparatus and its relation to rhythmic alterations in the heart's action, which would occupy more time than the limits of this paper will allow, as I simply wish to call your attention to some features of the first named
Leukemia Mutation
Authors: Tracy Hampton
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Boston Medical Library
Authors: Walter G. Phippen
Journal: New England Journal of Medicine (1949)

REPORT OF THE PRESIDENT*At this meeting I complete my term as your president, and it gives me considerable pleasure to present my third annual report on the state of the Library.When I assumed office it did not take much study to realize that the first great need of the Library was more income. The budget did not balance, and we were drawing heavily on our invested funds, both restricted and unrestricted, to pay current bills. Consequently, economy was the rule, and while the Librarian and the Director did extraordinarily well with a very loyal staff, the service was . . .
Transactions of the Medical Society of the State of New York, for the Year 1884.
Journal: JAMA (1885)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3886: Impact of nanosuspension of CZ48, a lactone stabilized camptothecin, on the biliary excretion and enterohepatic recycling of its active moiety, camptothecin
Authors: Diana S-L Chow, Yu Jin Kim, Dong Dong, Xiaohui Li
Journal: Cancer Research (2019)

Abstract The biliary excretions of CZ48, a lactone-stabilized camptothecin (CPT), and CPT were evaluated in bile duct-cannulated SD rats after a single oral administration of CZ48 in two different types of formulations, co-solvent solution (CoS, control, in the mixture of DMSO, PEG 400, and EtOH (2:2:1, v/v/v) at 10 mg/ml) and nanosuspension (NS with stabilizers of TW 80 and F-108, sustained release of CZ48). Enterohepatic recycling was further characterized by collecting bile intermittently or continuously to modulate the recycling system in the rats. The results demonstrated that CZ48 and CPT were secreted into the bile as their parent forms with the dominant secretion of CPT as compared to CZ48. The AUCs0-12h of CPT in bile were 213.45 ± 232.09 and 250.40 ± 134.83 ng/ml*h/[mg/kg] in CoS and NS groups, respectively, which were 18.39 and 34.16 times higher than those of CZ48 (11.61 ± 7.99 ng/ml*h/[mg/kg] in the CoS group and 7.33 ± 2.22 ng/ml*h/[mg/kg] in the NS group). On the contrary, the AUCs0-12h of CZ48 in plasma were 6.10 and 6.80 times higher than those of CPT in CoS and NS groups, respectively. There was no significant impact of NS on the plasma AUCs0-12h and biliary excretions of CZ48 and CPT. Their concentrations in plasma and biliary excretions were sustained for 8 or 12 h post oral dose. Moreover, a pharmacokinetic co-model for CZ48 and CPT in plasma and bile was developed to characterize the biliary secretion and saturable process of enterohepatic recycling of CZ48 and CPT in rats. Citation Format: Diana S-L Chow, Yu Jin Kim, Dong Dong, Xiaohui Li. Impact of nanosuspension of CZ48, a lactone stabilized camptothecin, on the biliary excretion and enterohepatic recycling of its active moiety, camptothecin [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3886.