tbuckley/cabot-search huggingface dataset:
Bleeding and thrombotic events in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study
Authors: Alexandre Mansour, Erwan Flecher, Matthieu Schmidt, Bertrand Rozec, Isabelle Gouin-Thibault, Maxime Esvan, Claire Fougerou, Bruno Levy, Alizée Porto, James T. Ross, Marylou Para, Sabrina Manganiello, Guillaume Lebreton, André Vincentelli, Nicolas Nesseler, Marc Pierrot, Sidney Chocron, Guillaume Flicoteaux, Philippe Mauriat, Alexandre Ouattara, Hadrien Roze, Olivier Huet, Marc-Olivier Fischer, Claire Alessandri, Raphel Bellaïche, Ophélie Constant, Quentin de Roux, André Ly, Arnaud Meffert, Jean-Claude Merle, Nicolas Mongardon, Lucile Picard, Elena Skripkina, Thierry Folliguet, Antonio Fiore, Nicolas D’ostrevy, Marie-Catherine Morgan, Pierre-Grégoire Guinot, Maxime Nguyen, Lucie Gaide-Chevronnay, Nicolas Terzi, Gwenhaël Colin, Olivier Fabre, Arash Astaneh, Justin Issard, Elie Fadel, Dominique Fabre, Antoine Girault, Julien Guihaire, Iolande Ion, Jean Baptiste Menager, Delphine Mitilian, Olaf Mercier, François Stephan, Jacques Thes, Jerôme Jouan, Thibault Duburcq, Valentin Loobuyck, Mouhammed Moussa, Agnes Mugnier, Natacha Rousse, Olivier Desebbe, Jean-Luc Fellahi, Roland Henaine, Matteo Pozzi, Jean-Christophe Richard, Zakaria Riad, Christophe Guervilly, Sami Hraiech, Laurent Papazian, Matthias Castanier, Charles Chanavaz, Cyril Cadoz, Sebastien Gette, Guillaume Louis, Erick Portocarrero, Philippe Gaudard, Kais Brini, Nicolas Bischoff, Antoine Kimmoun, Mathieu Mattei, Pierre Perez, Alexandre Bourdiol, Yannick Hourmant, Pierre-Joachim Mahé, Pierre Jaquet, Brice Lortat-Jacob, Pierre Mordant, Patrick Nataf, Juliette Patrier, Sophie Provenchère, Morgan Roué, Romain Sonneville, Alexy Tran-Dinh, Paul-Henri Wicky, Charles Al Zreibi, Bernard Cholley, Yannis Guyonvarch, Sophie Hamada, Anatole Harrois, Jordi Matiello, Thomas Kerforne, Corentin Lacroix, Nicolas Brechot, Alain Combes, Juliette Chommeloux, Jean Michel Constantin, Cosimo D’alessandro, Pierre Demondion, Alexandre Demoule, Martin Dres, Guillaume Fadel, Muriel Fartoukh, Guillaume Hekimian, Charles Juvin, Pascal Leprince, David Levy, Charles Edouard Luyt, Marc Pineton De Chambrun, Thibaut Schoell, Pierre Fillâtre, Nicolas Massart, Roxane Nicolas, Maud Jonas, Charles Vidal, Nicolas Allou, Salvatore Muccio, Dario Di Perna, Vito-Giovanni Ruggieri, Bruno Mourvillier, Amedeo Anselmi, Karl Bounader, Yoann Launey, Thomas Lebouvier, Alessandro Parasido, Florian Reizine, Philippe Seguin, Emmanuel Besnier, Dorothée Carpentier, Thomas Clavier, Pierre-Emmanuel Falcoz, Anne Olland, Marion Villard, Fanny Bounes, François Labaste, Vincent Minville, Antoine Guillon, Yannick Fedun
Journal: Intensive Care Medicine (2022)
Incidental Murmur in a Preadolescent Boy
Authors: Jordan L. W. Lam, Sara Saleh, Cormac O. Maher
Journal: JAMA Cardiology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Immune landscape after allo-HSCT: TIGIT- and CD161-expressing CD4 T cells are associated with subsequent leukemia relapse
Authors: Viviane Gournay, Nicolas Vallet, Vivien Peux, Kristi Vera, Jennifer Bordenave, Marion Lambert, Aurélien Corneau, David Michonneau, Régis Peffault de Latour, Sophie Caillat-Zucman, Gérard Socié, Mathieu F. Chevalier
Journal: Blood (2022)
Description and Outcomes of an Innovative Concurrent Hospice-Dialysis Program
Authors: Natalie C. Ernecoff, Alexandra E. Bursic, Erica M. Motter, Keith Lagnese, Robert Taylor, Jane O. Schell
Journal: Journal of the American Society of Nephrology (2022)

Compared with the general Medicare population, patients with ESKD have worse quality metrics for end-of-life care, including a higher percentage experiencing hospitalizations and in-hospital deaths and a lower percentage referred to hospice. We developed a Concurrent Hospice and Dialysis Program in which patients may receive palliative dialysis alongside hospice services. The Program aims to improve access to quality end-of-life care and, ultimately, improve the experiences of patients, caregivers, and clinicians.
Reply to J. Zhang et al
Authors: Miranda P. Steenbeek, Majke H.D. van Bommel, Johan Bulten, Rosella P.M.G. Hermens, Joanna IntHout, Joanne A. de Hullu
Journal: Journal of Clinical Oncology (2022)

The first point regards the history of breast cancer among women with serous tubal intraepithelial carcinoma (STIC) at risk-reducing salpingo-oophorectomy, and specifically the number of women with breast cancer among the women who developed peritoneal carcinomatosis (PC) during follow-up.The breast cancer history was known for 60 of the 115 patients with STIC and 944 of the 3,006 patients without STIC, and of these patients, respectively, 43.3% and 39.3% had a history of breast cancer.Among the women with STIC who developed PC during follow-up (n 5 15), a total of three (20.0%)had a history of breast cancer, six (40.0%) did not have had breast cancer, and for six (40.0%), the history of breast cancer was unknown.In the group of women without STIC who developed PC (n 5 12), these numbers were, respectively, one (8.3%),three (25.0%),and eight (66.7%).Thus, in the current data, there seems not be a clear association between a history of breast cancer and the risk of PC.However, the current data are too limited to draw definite conclusions.
Covid-19: Parts of England see hospital admissions more than double in two weeks
Authors: Emma Wilkinson
Journal: BMJ (2022)

<i>Background/Aim: Pancreatic stellate cells (PSC) play a critical role in pancreatic fibrosis and the apparent diffusion coefficient (ADC) value based on the diffusion-weighted image (DWI) from magnetic resonance imaging (MRI) may be a predictor of tissue fibrosis. This study aimed to evaluate the pancreas texture from both histopathological and radiological viewpoints and to investigate the effect of pancreas texture on occurrence of postoperative pancreatic fistula (PF). Patients and Methods: We divided 40 patients into soft-pancreas group and hard-pancreas group, according to the histopathological evaluation of pancreatic fibrosis. We compared ADC values and occurrences of PF between the two groups. Results: Histopathological measurement lengths of interlobular and intralobular fibrosis increased significantly with the progression of fibrosis grade and PSC stage, while PSC stage correlated significantly with fibrosis grade (r=0.868, p&lt;0.001). PF was detected in 14 out of 40 patients, including grade A in 7 patients and grade B/C in 7 patients, but there were no operative deaths. Pancreas texture (soft/hard), determined based on the combination of fibrosis grade and PSC stage, was 16/10 (no PF) and 14/0 (grade A/B/C PF) and the difference in the incidence was significant (p=0.022). Though ADC value was significantly lower in the hard-compared to the soft-pancreas group (1.48±0.42 vs. 1.73±0.27×10<sup>−3</sup> mm<sup>2</sup>/sec; p=0.033), there was no significant difference in ADC value between no PF versus grade A/B/C PF group. Conclusion: Histopathological evaluation of pancreas texture correlated negatively with ADC values and is critical to predict the occurrence of PF.</i>
mRNA vaccine development for cholangiocarcinoma: a precise pipeline
Authors: Tian-Yu Tang, Xing Huang, Gang Zhang, Ming-Hao Lu, Ting-Bo Liang
Journal: Military Medical Research (2022)

Abstract Cholangiocarcinoma (CHOL) is one of the most aggressive tumors worldwide and cannot be effectively treated by conventional and novel treatments, including immune checkpoint blockade therapy. The mRNA vaccine-based immunotherapeutic strategy has attracted much attention for various diseases, however, its application in CHOL is limited due to the thoughtlessness in the integration of vaccine design and patient selection. A recent study established an integrated path for identifying potent CHOL antigens for mRNA vaccine development and a precise stratification for identifying CHOL patients who can benefit from the mRNA vaccines. In spite of a promising prospect, further investigations should identify immunogenic antigens and onco-immunological characteristics of CHOL to guide the clinical application of CHOL mRNA vaccines in the future.
Management and outcome of native joint septic arthritis: a nationwide survey in French rheumatology departments, 2016–2017
Authors: Pauline Richebé, Guillaume Coiffier, Pascal Guggenbuhl, Denis Mulleman, Marion Couderc, Emanuelle Dernis, Valentine Deprez, Carine Salliot, Saik urien, Rachel Brault, Adeline Ruyssen-Witrand, Emmanuel Hoppe, Emmanuel Chatelus, Christian hubert roux, Sebastien Ottaviani, Marie Baufrere, Alexia Michaut, Loic Pauvele, Christelle Darrieutort-Laffite, Daniel Wendling, Pascal Coquerelle, Géraldine Bart, Elisabeth Gervais, Vincent Goeb, Marc Ardizzone, Edouard Pertuiset, Sophie Derolez, Jean Marc Ziza, René-Marc Flipo, Sophie Godot, Raphaele Seror
Journal: Annals of the Rheumatic Diseases (2022)

To describe current management and outcome of native joint septic arthritis (NJSA) in French rheumatology departments.
Evolutionary History of Sexual Differentiation Mechanism in Insects
Authors: Yasuhiko Chikami, Miki Okuno, Atsushi Toyoda, Takehiko Itoh, Teruyuki Niimi
Journal: Molecular Biology and Evolution (2022)

Alternative splicing underpins functional diversity in proteins and the complexity and diversity of eukaryotes. An example is the doublesex gene, the key transcriptional factor in arthropod sexual differentiation. doublesex is controlled by sex-specific splicing and promotes both male and female differentiation in holometabolan insects, whereas in hemimetabolan species, doublesex has sex-specific isoforms but is not required for female differentiation. How doublesex evolved to be essential for female development remains largely unknown. Here, we investigate ancestral states of doublesex using Thermobia domestica belonging to Zygentoma, the sister group of Pterygota, that is, winged insects. We find that, in T. domestica, doublesex expresses sex-specific isoforms but is only necessary for male differentiation of sexual morphology. This result supports the hypothesis that doublesex initially promoted male differentiation during insect evolution. However, T. domestica doublesex has a short female-specific region and upregulates the expression of vitellogenin homologs in females, suggesting that doublesex may already play some role in female morphogenesis of the common ancestor of Pterygota. Reconstruction of the ancestral sequence and prediction of protein structures show that the female-specific isoform of doublesex has an extended C-terminal disordered region in holometabolan insects but not in nonholometabolan species. We propose that doublesex acquired its function in female morphogenesis through a change in the protein motif structure rather than the emergence of the female-specific exon.
Integrating digital pathology and mathematical modelling to predict spatial biomarker dynamics in cancer immunotherapy
Authors: L. G. Hutchinson, O. Grimm
Journal: npj Digital Medicine (2022)

Abstract In oncology clinical trials, on-treatment biopsy samples are taken to confirm the mode of action of new molecules, among other reasons. Yet, the time point of sample collection is typically scheduled according to 'Expert Best Guess'. We have developed an approach integrating digital pathology and mathematical modelling to provide clinical teams with quantitative information to support this decision. Using digitised biopsies from an ongoing clinical trial as the input to an agent-based mathematical model, we have quantitatively optimised and validated the model demonstrating that it accurately recapitulates observed biopsy samples. Furthermore, the validated model can be used to predict the dynamics of simulated biopsies, with applications from protocol design for phase 1–2 studies to the conception of combination therapies, to personalised healthcare.
Serving the community: the returning GP
Authors: Adrian O’Dowd
Journal: BMJ (2022)

This study was undertaken to determine the role of aquaporin 2 (AQP2) in the impaired urinary concentrating capacity observed in patients who underwent pyeloplasty because of congenital unilateral hydronephrosis as a result of pyeloureteral junction disease. Twelve children (mean age, 8 ± 2 mo) were examined in the study. From day 1 to day 5 after surgery, the urine was collected separately from pyelostomy draining only from the postobstructed kidney and from the bladder catheter draining mostly from the contralateral kidney used as internal control. After pyeloplasty, the postobstructed kidney was characterized by a reduced urinary excretion of AQP2 (∼54%) associated with polyuria that persisted from day 1 to day 5 (433 ± 58 <i>versus</i> 310 ± 74 ml/24 h at day 1; 326 ± 44 <i>versus</i> 227 ± 26 ml/24 h at day 5). In parallel, urine osmolality from the postobstructed kidney was significantly reduced compared with the contralateral kidney (111 ± 12 <i>versus</i> 206 ± 49 at day 1; 136 ± 24 <i>versus</i> 235 ± 65 mOsm/kg at day 5). Creatinine clearance from the postobstructed kidney was not significantly different compared with the contralateral kidney throughout the 4 d after surgery. However, on day 5, creatinine clearance from the postobstructed kidney became significantly lower. Prostaglandin E2 in the urine from postobstructed kidneys was found to be twofold higher than in the contralateral samples (26.0 ± 6.7 <i>versus</i> 13.5 ± 2.5 at day 5). It is concluded that (<i>1</i>) the selective downregulation of AQP2 in postobstructed kidney may account for the higher excretion of hypotonic urine, and (2) the local increase in prostaglandin E2 synthesis in postobstructed kidney may be involved in AQP2 downregulation and in maintaining a GFR similar to that of the contralateral kidney.
Drug company asks FDA to approve over-the-counter contraceptive pill
Authors: Janice Hopkins Tanne
Journal: BMJ (2022)

<h3>Objective:</h3> To develop a comprehensive conceptual framework of tobacco industry tactics in four countries in South East Asia for the purpose of: (1) generating consensus on key areas of importance and feasibility for regional and cross country tobacco industry monitoring and surveillance; (2) developing measures to track and monitor the effects of the tobacco industry and to design counterstrategies; and (3) building capacity to improve tobacco control planning in the participating countries. <h3>Design:</h3> A structured conceptualisation methodology known as concept mapping was used. The process included brainstorming, sorting and rating of statements describing industry activities. Statistical analyses used multidimensional scaling and cluster analysis. Interpretation of the maps was participatory, using regional tobacco control researchers, practitioners, and policy makers during a face to face meeting. <h3>Participants:</h3> 31 participants in this study come from the four countries represented in the project along with six people from the Johns Hopkins Blomberg School of Public Health. <h3>Conclusions:</h3> The map shows eight clusters of industry activities within the four countries. These were arranged into four general sectors: economics, politics, public relations and deception. For project design purposes, the map indicates areas of importance and feasibility for monitoring tobacco industry activities and serves as a basis for an initial discussion about action planning. Furthermore, the development of the map used a consensus building process across different stakeholders or stakeholder agencies and is critical when developing regional, cross border strategies for tracking and surveillance.
Combining single-cell tracking and omics improves blood stem cell fate regulator identification
Authors: A. Wehling, D. Loeffler, Y. Zhang, T. Kull, C. Donato, B. Szczerba, G. Camargo Ortega, M. Lee, A. Moor, B. Göttgens, N. Aceto, T. Schroeder
Journal: Blood (2022)

Molecular programs initiating cell fate divergence (CFD) are difficult to identify. Current approaches usually compare cells long after CFD initiation, therefore missing molecular changes at its start. Ideally, single cells that differ in their CFD molecular program but are otherwise identical are compared early in CFD. This is possible in diverging sister cells, which were identical until their mother's division and thus differ mainly in CFD properties. In asymmetrically dividing cells, divergent daughter fates are prospectively committed during division, and diverging sisters can thus be identified at the start of CFD. Using asymmetrically dividing blood stem cells, we developed a pipeline (ie, trackSeq) for imaging, tracking, isolating, and transcriptome sequencing of single cells. Their identities, kinship, and histories are maintained throughout, massively improving molecular noise filtering and candidate identification. In addition to many identified blood stem CFD regulators, we offer here this pipeline for use in CFDs other than asymmetric division.
Faecal immunochemical testing (FIT) in patients with signs or symptoms of suspected colorectal cancer (CRC): a joint guideline from the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of Gastroenterology (BSG)
Authors: Kevin J Monahan, Michael M Davies, Muti Abulafi, Ayan Banerjea, Brian D Nicholson, Ramesh Arasaradnam, Neil Barker, Sally Benton, Richard Booth, David Burling, Rachel Victoria Carten, Nigel D'Souza, James Edward East, Jos Kleijnen, Michael Machesney, Maria Pettman, Jenny Pipe, Lance Saker, Linda Sharp, James Stephenson, Robert JC Steele
Journal: Gut (2022)

Faecal immunochemical testing (FIT) has a high sensitivity for the detection of colorectal cancer (CRC). In a symptomatic population FIT may identify those patients who require colorectal investigation with the highest priority. FIT offers considerable advantages over the use of symptoms alone, as an objective measure of risk with a vastly superior positive predictive value for CRC, while conversely identifying a truly low risk cohort of patients. The aim of this guideline was to provide a clear strategy for the use of FIT in the diagnostic pathway of people with signs or symptoms of a suspected diagnosis of CRC. The guideline was jointly developed by the Association of Coloproctology of Great Britain and Ireland/British Society of Gastroenterology, specifically by a 21-member multidisciplinary guideline development group (GDG). A systematic review of 13 535 publications was undertaken to develop 23 evidence and expert opinion-based recommendations for the triage of people with symptoms of a suspected CRC diagnosis in primary care. In order to achieve consensus among a broad group of key stakeholders, we completed an extended Delphi of the GDG, and also 61 other individuals across the UK and Ireland, including by members of the public, charities and primary and secondary care. Seventeen research recommendations were also prioritised to inform clinical management.
Fall in colonoscopy completion rates is short lived after a break in performing colonoscopy: a study of how the COVID-19-impacted period affected colonoscopy performance
Authors: David F. W. Tai, Mo Thoufeeq
Journal: Endoscopy (2022)

During the first COVID-19 outbreak, UK endoscopy activity fell to 12 % during the COVID-impacted period between March and June 2020 [1]. Consequently, the majority of endoscopists had a simultaneous hiatus in colonoscopy activity, which may have affected performance measures. In this study, the effect of the 3-month COVID-impacted period on key performance indicators of colonoscopists was assessed.
Carbonic Anhydrase Inhibitors: A New Dawn for the Treatment of Obstructive Sleep Apnea
Authors: Riken Chen, Huizhao Liao, Xiaojuan Chen, Chaoyu Wang, Huiyu Wu, Zhenzhen Zheng, Jianmin Lu, Junyan Lin, Zijie Huang, Jiangpeng Lin, Nanshan Zhong, Nuofu Zhang
Journal: American Journal of Respiratory and Critical Care Medicine (2022)
The Myanmar health crisis engulfing India’s under-resourced border state
Authors: Makepeace Sitlhou, Ninglun Hanghal
Journal: BMJ (2022)

Mizoram, one of the poorest states in India, is bordered by Myanmar on three sides, and the flood of refugees it has welcomed since the 2021 coup have its healthcare system on its knees. <b>Makepeace Sitlhou</b> and <b>Ninglun Hanghal</b> report
Intensive Multimodality Therapy for Extraocular Retinoblastoma: A Children's Oncology Group Trial (ARET0321)
Authors: Ira J. Dunkel, Jin Piao, Guillermo L. Chantada, Anuradha Banerjee, Sherif Abouelnaga, Jeffrey C. Buchsbaum, Thomas E. Merchant, Meaghan M. Granger, Rima F. Jubran, Joanna L. Weinstein, Lauren Saguilig, David H. Abramson, Mark D. Krailo, Carlos Rodriguez-Galindo, Murali M. Chintagumpala
Journal: Journal of Clinical Oncology (2022)

Metastatic retinoblastoma has a poor prognosis when treated with conventional chemotherapy and radiation therapy (RT). Intensified therapy may improve the outcome.A prospective, international trial enrolled patients with extraocular retinoblastoma. Patients with stage II or III (locoregional) retinoblastoma received four cycles of chemotherapy, followed by involved field RT (45 Gy). Patients with stage IVa or IVb (metastatic or trilateral) retinoblastoma also received four cycles of chemotherapy and those with ≥ partial response then received one cycle of high-dose carboplatin, thiotepa, and etoposide with autologous hematopoietic stem-cell support. Patients with stage IVa or IVb with residual tumor postchemotherapy received RT. The proportion of patients who achieved event-free survival would be reported and compared with historical controls separately for each of the three groups of patients.Fifty-seven eligible patients were included in the analyses. Event-free survival at 1 year was 88.1% (90% CI, 66.6 to 96.2) for stage II-III, 82.6% (90% CI, 61.0 to 92.9) for stage IVa, and 28.3% (90% CI, 12.7 to 46.2) for stage IVb/trilateral. Toxicity was significant as expected and included two therapy-related deaths.Intensive multimodality therapy is highly effective for patients with regional extraocular retinoblastoma and stage IVa metastatic retinoblastoma. Although the study met its aim for stage IVb, more effective therapy is still required for patients with CNS involvement (ClinicalTrials.gov identifier: NCT00554788).