POS0521 MORTALITY RATE OF GOUT PATIENTS HAS BEEN INCREASED IN KOREA
Authors: K. W. Moon
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Many epidemiologic studies support an association between gout and increased premature mortality. However, there has been no study on mortality and cause of death in Korean patients with gout with large scale data. Therefore, we intended to investigate the risk of death, the change of mortality rate over time, and main cause of death in Korean patient with gout with the national insurance database. <h3>Objectives</h3> The purpose of this study is to assess the mortality rate, trends of mortality rate over time, and cause of death of gout patients in Korea. <h3>Methods</h3> Using Korean National Health Insurance Service data, we conducted a cohort study on gout patients. Gout patients were defined as those aged ≥ 20 years who were diagnosed as gout between 2002 and 2014, and control patients were matched with gout patients (1:1 ratio) after frequency matching for age, sex and index year. Primary outcome was all-cause mortality and observation period was between 2007 and 2015. Covariates were age, sex and comorbidities (hypertension, diabetes, chronic renal failure, ischemic heart disease, cerebrovascular disease and cancer). We calculated standardized mortality rate (SMR), and hazard ratio (HR) in Cox regression, adjusting potential confounders. <h3>Results</h3> This study included 18,406 gout patients and an equal number of matched controls. Baseline characteristics of gout and control patients are displayed in Table 1. Total 1,926 deaths occurred, and SMR of gout patients showed increasing tendency from 2007 to 2015 (Figure 1). The most common cause of death in Korean gout patients was chronic renal failure. Multivariate Cox regression analysis showed that gout patients showed increased risks of all-cause mortality (HR 1.182, 95% CI 1.098-1.274) after adjusting age, sex, and comorbidities. <h3>Conclusion</h3> Gout patients were associated with higher risk of all-cause mortality. The mortality rate of gout patients showed increasing tendency between 2007 and 2015, and most common cause of death was chronic renal failure. <h3>References</h3> [1]Weisman A, Tomlinson GA, Lipscombe LL, Perkins BA, Hawker GA. Association between allopurinol and cardiovascular outcomes and all-cause mortality in diabetes: A retrospective, population-based cohort study. Diabetes Obes Metab. 2019;21(6):1322-9. [2]Cohen SD, Kimmel PL, Neff R, Agodoa L, Abbott KC. Association of incident gout and mortality in dialysis patients. J Am Soc Nephrol. 2008;19(11):2204-10. [3]Vargas-Santos AB, Neogi T, da Rocha Castelar-Pinheiro G, Kapetanovic MC, Turkiewicz A. Cause-Specific Mortality in Gout: Novel Findings of Elevated Risk of Non-Cardiovascular-Related Deaths. Arthritis Rheumatol. 2019;71(11):1935-42. [4]Kiadaliri A, Moreno-Betancur M, Turkiewicz A, Englund M. Educational inequalities in all-cause and cause-specific mortality among people with gout: a register-based matched cohort study in southern Sweden. Int J Equity Health. 2019;18(1):164. [5]Kuo CF, Luo SF. Gout: Risk of premature death in gout unchanged for years. Nat Rev Rheumatol. 2017;13(4):200-1. [6]Keller SF, Rai SK, Lu N, Oza A, Jorge AM, Zhang Y, et al. Statin use and mortality in gout: A general population-based cohort study. Semin Arthritis Rheum. 2018;48(3):449-55. [7]Fisher MC, Rai SK, Lu N, Zhang Y, Choi HK. The unclosing premature mortality gap in gout: a general population-based study. Ann Rheum Dis. 2017;76(7):1289-94. [8]Yen FS, Hsu CC, Li HL, Wei JC, Hwu CM. Urate-lowering therapy may mitigate the risks of hospitalized stroke and mortality in patients with gout. PLoS One. 2020;15(6):e0234909. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.