tbuckley/cabot-search huggingface dataset:
Maternal Depression, Prenatal SSRI Exposure, and Brain Trajectories in Childhood
Authors: Ardesheer Talati
Journal: JAMA Psychiatry (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Brain Networks and Adolescent Alcohol Use
Authors: Sarah W. Yip, Sarah D. Lichenstein, Qinghao Liang, Bader Chaarani, Alecia Dager, Godfrey Pearlson, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane H. Fröhner, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Hugh Garavan
Journal: JAMA Psychiatry (2023)

Alcohol misuse in adolescence is a leading cause of disability and mortality in youth and is associated with higher risk for alcohol use disorder. Brain mechanisms underlying risk of alcohol misuse may inform prevention and intervention efforts.
On Skinner's pendulum: A framework for assessing s-frame hope
Authors: Cait Lamberton
Journal: Behavioral and Brain Sciences (2023)

Abstract Unsatisfied with the effects of behavioral economics’ i-frame, “technology of behavior,” Chater &amp; Loewenstein call for a pendulum swing back to the s-frame, suggesting that such an approach offers a more hopeful path toward societal well-being. In this commentary, I offer a framework to think about this pendulum swing, as well as the scope – and limits – of this hope.
Optimizing behavior change through integration of individual- and system-level intervention approaches
Authors: Martin S Hagger, Kyra Hamilton
Journal: Behavioral and Brain Sciences (2023)

We contend that individual-level ("i-frame") intervention strategies can be appropriately integrated with system-level ("s-frame") strategies to optimize population-level behavior change. We outline instances of effective "i-frame" interventions, and how coordinated, integrated, well-resourced interventions that encompass components at both levels, and has organizational and user-group support, may optimize sustained behavior change intervention efforts, and allay practices that undermine "s-frame" components.
Phase 3 Trial of Concizumab in Hemophilia with Inhibitors
Authors: Tadashi Matsushita, Amy Shapiro, Aby Abraham, Pantep Angchaisuksiri, Giancarlo Castaman, Katarina Cepo, Roseline d’Oiron, Melissa Frei-Jones, Ai-Sim Goh, Jesper Haaning, Sanja Hald Jacobsen, Johnny Mahlangu, Mary Mathias, Keiji Nogami, Josephine Skovgaard Rasmussen, Oleksandra Stasyshyn, Huyen Tran, Kateryna Vilchevska, Laura Villarreal Martinez, Jerzy Windyga, Chur Woo You, Nadezhda Zozulya, Bulent Zulfikar, Victor Jiménez-Yuste
Journal: New England Journal of Medicine (2023)

Concizumab is an anti-tissue factor pathway inhibitor monoclonal antibody designed to achieve hemostasis in all hemophilia types, with subcutaneous administration. A previous trial of concizumab (explorer4) established proof of concept in patients with hemophilia A or B with inhibitors.We conducted the explorer7 trial to assess the safety and efficacy of concizumab in patients with hemophilia A or B with inhibitors. Patients were randomly assigned in a 1:2 ratio to receive no prophylaxis for at least 24 weeks (group 1) or concizumab prophylaxis for at least 32 weeks (group 2) or were nonrandomly assigned to receive concizumab prophylaxis for at least 24 weeks (groups 3 and 4). After a treatment pause due to nonfatal thromboembolic events in three patients receiving concizumab, including one from the explorer7 trial, concizumab therapy was restarted with a loading dose of 1.0 mg per kilogram of body weight, followed by 0.2 mg per kilogram daily (potentially adjusted on the basis of concizumab plasma concentration as measured at week 4). The primary end-point analysis compared treated spontaneous and traumatic bleeding episodes in group 1 and group 2. Safety, patient-reported outcomes, and pharmacokinetics and pharmacodynamics were also assessed.Of 133 enrolled patients, 19 were randomly assigned to group 1 and 33 to group 2; the remaining 81 were assigned to groups 3 and 4. The estimated mean annualized bleeding rate in group 1 was 11.8 episodes (95% confidence interval [CI], 7.0 to 19.9), as compared with 1.7 episodes (95% CI, 1.0 to 2.9) in group 2 (rate ratio, 0.14 [95% CI, 0.07 to 0.29]; P<0.001). The overall median annualized bleeding rate for patients receiving concizumab (groups 2, 3, and 4) was 0 episodes. No thromboembolic events were reported after concizumab therapy was restarted. The plasma concentrations of concizumab remained stable over time.Among patients with hemophilia A or B with inhibitors, the annualized bleeding rate was lower with concizumab prophylaxis than with no prophylaxis. (Funded by Novo Nordisk; explorer7 ClinicalTrials.gov number, NCT04083781.).
Severe COVID-19 Linked to Enduring Immune System Changes
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Case 27-2023: A 53-Year-Old Woman with Celiac Disease and Upper Gastrointestinal Bleeding
Authors: Nikroo Hashemi, Emily W. Lopes, Ranjodh S. Dhami, Angela E. Lin, Jinesa Moodley
Journal: New England Journal of Medicine (2023)

A 53-year-old woman with celiac disease was admitted with diarrhea and hemorrhagic shock. Imaging was notable for a retroperitoneal mass and horseshoe kidney. A diagnosis was made.
i-Frame interventions enhance s-frame interventions
Authors: Jiaying Zhao, Frances S. Chen
Journal: Behavioral and Brain Sciences (2023)

Abstract We argue that i-frame interventions can and do increase support for systemic reforms, and s-frame interventions should be pursued in parallel to address key societal issues. Without accompanying i-frame interventions, s-frame interventions can fail. We offer an operant conditioning framework to generate positive spillover effects. Behavioral scientists should develop i-frame interventions that enhance, rather than compete with, s-frame interventions.
Prenatal Antidepressant Exposure and Offspring Brain Morphologic Trajectory
Authors: Dogukan Koc, Henning Tiemeier, Bruno H. Stricker, Ryan L. Muetzel, Manon Hillegers, Hanan El Marroun
Journal: JAMA Psychiatry (2023)

Clinical decision-making on antidepressant treatment during pregnancy, particularly selective serotonin reuptake inhibitors (SSRIs), is challenging, as both prenatal SSRI exposure and maternal depressive symptoms may be associated with negative outcomes in offspring.
The real cause of our complicity: The preoccupation with human weakness
Authors: Ralph Hertwig
Journal: Behavioral and Brain Sciences (2023)

Abstract Chater &amp; Loewenstein offer an incisive criticism of how behavioral sciences and public policy have become complicit with corporations in blaming public health and societal problems on individual weaknesses, thus deflecting support away from systemic reforms. However, their analysis stops short of holding the field to account in one important respect: its preoccupation with human irrationality and weakness.
Using effective psychological techniques to subvert a US sociopolitical context
Authors: Ilana J Mermelstein, Stephanie D Preston
Journal: Behavioral and Brain Sciences (2023)

Abstract Chater &amp; Loewenstein argue for a shift in focus from individual- to structural-level approaches to societal ills. This is valid and important but overlooks the barriers inherent in the current US partisan context. Psychology can be applied to help people of mixed allyship join together, to effectively and quickly force institutions and corporations to accept structural change.
Preventing Heat-Related Illness among Outdoor Workers — Opportunities for Clinicians and Policymakers
Authors: Rosemary K. Sokas, Emily Senay
Journal: New England Journal of Medicine (2023)

Interview with Rosemary Sokas on the risk of heat-related illness among U.S. workers as temperatures increase. (14:18)Download Efforts to implement heat-safety protections for workers are falling short. Given these gaps, clinicians can help support their patients who may be at risk for heat-related illness.
Deep Brain Stimulation May Improve Function Years After Stroke
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Details on Ethical Review and Data Collection Added to Methods Section
Journal: JAMA Network Open (2023)

Sara Benitez Majano, PhD; Georgios Lyratzopoulos, MD; Niek J. de Wit, PhD; Becky White, MPhil; Bernard Rachet, PhD; Charles Helsper, PhD; Juliet Usher-Smith, PhD; Cristina Renzi, PhD
Geospatial Assessment of Racial/Ethnic Composition, Social Vulnerability, and Lead Water Service Lines in New York City
Authors: Anne E. Nigra, Wil Lieberman-Cribbin, Benjamín C. Bostick, Steven N. Chillrud, Daniel Carrión
Journal: Environmental Health Perspectives (2023)

Background: The state of New York expects to receive $115 million in 2022 alone from the U.S. Infrastructure Investment and Jobs Act to support the replacement of lead water service lines. Objectives: Our objective was to determine the number and proportion of potential lead water service lines across New York City (NYC) and to evaluate the association between census tract–level racial/ethnic composition, housing vulnerability, and child lead exposure vulnerability with service line type (Potential Lead, Unknown) for n=2,083 NYC tracts. Methods: We conducted a descriptive analysis assessing water service line material recorded in the NYC Department of Environmental Protection’s Lead Service Line Location Coordinates database. We used conditional autoregressive Bayesian Poisson models to assess the relative risk [RR; median posterior estimates, and 95% credible interval (CrI)] of service line type per 20% higher proportion of residents in a given racial/ethnic group and per higher housing vulnerability and child lead exposure vulnerability index scores corresponding to the interquartile range. We also evaluated the associations in flexible natural cubic spline models. Results: Out of 854,672 residential service line records, 136,891 (16.0%) were Potential Lead, and 227,443 (26.6%) were Unknown. In fully adjusted models, higher proportions of Hispanic/Latino residents and higher child lead exposure vulnerability were associated with Potential Lead service lines in flexible spline models and linear models [RR=1.15 (95% CrI: 1.11, 1.21) and RR=1.11 (95% CrI: 1.02, 1.20), respectively]. Associations were modified by borough; Potential Lead service lines were associated with higher proportions of non-Hispanic White and non-Hispanic Asian residents in the Bronx and Manhattan, and with higher proportions of non-Hispanic Black residents in Queens. Discussion: NYC has a high number of Potential Lead and Unknown water service lines. Communities with a high proportion of Hispanic/Latino residents and those with children who are already highly vulnerable to lead exposures from numerous sources are disproportionately impacted by Potential Lead service lines. These findings can inform equitable service line replacement across New York state and NYC. https://doi.org/10.1289/EHP12276
Timing of Primary Surgery for Cleft Palate
Authors: Carrol Gamble, Christina Persson, Elisabeth Willadsen, Liz Albery, Helene Soegaard Andersen, Melissa Zattoni Antoneli, Malin Appelqvist, Ragnhild Aukner, Pia Bodling, Melanie Bowden, Karin Brunnegård, Gillian Cairns, Samantha Calladine, Linsay Campbell, Jill Clayton-Smith, Rachael Cooper, Elizabeth Conroy, Ahmed El-Angbawi, Berit Kildegaard Emborg, Josefin Enfält Wikman, Beth Fitzpatrick, Ana Paula Fukushiro, Cristina Guedes de Azevedo Bento Gonçalves, Christina Havstam, Anne Katherine Hvistendahl, Line Dahl Jorgensen, Kristina Klinto, Marit Berntsen Kvinnsland, Catriona Larham, Jorunn Lemvik, Louise Leturgie, Eva Liljerehn, Natalie Lodge, Anette Lohmander, Siobhan McMahon, Felicity Mehendale, Haline Coracine Miguel, Marianne Moe, Joan Bogh Nielsen, Jill Nyberg, Nina-Helen Pedersen, Ginette Phippen, Silvia Helena Alvarez Piazentin-Penna, Kathryn Patrick, Lindsay Pliskin, Lucy Rigby, Gunvor Semb, Lucy Southby, Maria Sporre, Ann-Sofie Björkman Taleman, Jorid Tangstad, Inge Elly Kiemle Trindade, Imogen Underwood, Stephanie van Eeden, Liisi Raud Westberg, Paula Ruth Williamson, Renata Paciello Yamashita, Kevin Munro, Tanya Walsh, William Shaw
Journal: New England Journal of Medicine (2023)

Among infants with isolated cleft palate, whether primary surgery at 6 months of age is more beneficial than surgery at 12 months of age with respect to speech outcomes, hearing outcomes, dentofacial development, and safety is unknown.
Poly-γ-glutamic acid nanoparticles as adjuvant and antigen carrier system for cancer vaccination
Authors: Vahideh Mohammadzadeh, Niloufar Rahiman, Horacio Cabral, Sabina Quader, Mohammad Reza Zirak, Mohammad Ehsan Taghavizadeh Yazdi, Mahmoud Reza Jaafari, Seyedeh Hoda Alavizadeh
Journal: Journal of Controlled Release (2023)
Surgeon Sex and Long-Term Postoperative Outcomes Among Patients Undergoing Common Surgeries
Authors: Christopher J. D. Wallis, Angela Jerath, Khatereh Aminoltejari, Kirusanthy Kaneshwaran, Arghavan Salles, Natalie Coburn, Frances C. Wright, Lesley Gotlib Conn, Zachary Klaassen, Amy N. Luckenbaugh, Sanjana Ranganathan, Carlos Riveros, Colin McCartney, Kathleen Armstrong, Barbara Bass, Allan S. Detsky, Raj Satkunasivam
Journal: JAMA Surgery (2023)

Sex- and gender-based differences in a surgeon's medical practice and communication may be factors in patients' perioperative outcomes. Patients treated by female surgeons have improved 30-day outcomes. However, whether these outcomes persist over longer follow-up has not been assessed.
Proteomic Atlas of Atherosclerosis: The Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes, and Outcomes
Authors: Konstantinos Theofilatos, Stefan Stojkovic, Maria Hasman, Sander W. van der Laan, Ferheen Baig, Javier Barallobre-Barreiro, Lukas Emanuel Schmidt, Siqi Yin, Xiaoke Yin, Sean Burnap, Bhawana Singh, Jude Popham, Olesya Harkot, Stephanie Kampf, Maja Carina Nackenhorst, Andreas Strassl, Christian Loewe, Svitlana Demyanets, Christoph Neumayer, Martin Bilban, Christian Hengstenberg, Kurt Huber, Gerard Pasterkamp, Johann Wojta, Manuel Mayr
Journal: Circulation Research (2023)

Using proteomics, we aimed to reveal molecular types of human atherosclerotic lesions and study their associations with histology, imaging, and cardiovascular outcomes.
A Functional Connectome-Based Neural Signature for Individualized Prediction of Antipsychotic Response in First-Episode Psychosis
Authors: Hengyi Cao, Todd Lencz, Juan A. Gallego, Jose M. Rubio, Majnu John, Anita D. Barber, Michael L. Birnbaum, Delbert G. Robinson, Anil K. Malhotra
Journal: American Journal of Psychiatry (2023)

Identification of robust biomarkers that predict individualized response to antipsychotic treatment at the early stage of psychotic disorders remains a challenge in precision psychiatry. The aim of this study was to investigate whether any functional connectome-based neural traits could serve as such a biomarker.
Diagnosis of an intraductal papillary neoplasm of the bile duct with fibrovascular stalks using detective flow imaging
Authors: Shunsuke Omoto, Mamoru Takenaka, Tomohiro Fukunaga, Ayana Okamoto, Yoriaki Komeda, Seok Jeong, Masatoshi Kudo
Journal: Endoscopy (2023)

Intraductal papillary neoplasm of the bile duct (IPNB) is a type of epithelial tumor characterized by papillary proliferation within the bile duct. It is defined histologically as a papillary or villous neoplasm covering the delicate fibrovascular stalks within the bile ducts [1] [2]; however, imaging of the fibrovascular stalks has not previously been reported in IPNB. Recent studies have reported on the usefulness of detective flow imaging (DFI) during endoscopic ultrasound (EUS) for the detailed evaluation of vessels in pancreaticobiliary disease, without the use of contrast agents [3] [4] [5]. Herein, we describe the usefulness of DFI in identifying the fibrovascular stalks in IPNB.
Pancreatic sphincterotomy allows removal of a fractured stone basket trapped in the pancreatic duct after lithotripsy
Authors: Yan Chen, Li Yang, Ting Yang, Cui Liu, Jie Chen
Journal: Endoscopy (2023)

A 57-year-old woman presented with recurrent epigastric pain. Computed tomography of the abdomen revealed a 26-mm pancreatic stone obstructing the main pancreatic duct (MPD) in the body portion ([Fig. 1]). We performed three sessions of extracorporeal shockwave lithotripsy (ESWL) using a third-generation lithotripter (Delta Compact II; Dornier MedTech, Weßling, Germany). Up to 5000 shocks were delivered per therapeutic session on a scale of 1 to 6, with a frequency of 120 shocks/min. Endoscopic retrograde cholangiopancreatography (ERCP) was routinely performed to remove the pancreatolith after ESWL to avoid steinstrasse. After sphincterotomy, we attempted to remove the pancreatolith with an eight-wire basket (MB5-2X4-8; Wilson-Cook Medical Inc., Bloomington, Indiana, USA); however, the basket became trapped by the calculi near the pancreatic orifice at the papilla ([Fig. 2]). The first solution we thought of was mechanical lithotripsy, and as we feared, the wires broke near the handle of the lithotripter ([Fig. 3 a, b]). Attempted reduction of the calculi with forceps and re-cannulating the MPD both failed. We employed a DualKnife (KD-650U, Olympus Corporation, Tokyo, Japan) to extend the sphincterotomy by approximately 3 mm. With the exposure of the trapped pancreatolith, forceps removed part of the calculi at the papilla. A guidewire was then successfully passed through the fractured basket and pancreatolith complex, and the impacted complex was retrieved with a balloon (AMH-RBT; Anrei Medical, Hangzhou, China). Following this, the fractured basket was also successfully removed by forceps ([Video 1]). The fragmented pancreatolith was also successfully removed by balloon and the patient was discharged uneventfully.
Silk Acid as an Implantable Biomaterial for Tissue Regeneration
Authors: Ziyang Sun, Ruochuan Huang, Hao Lyu, Xin Yu, Wenzhao Wang, Jinghang Li, Xingyu Lu, Chengchen Guo
Journal: Advanced Healthcare Materials (2023)

Abstract Silk fibroin derived from the domesticated silkworm Bombyx mori is a protein‐based biopolymer with low immunogenicity, intrinsic biodegradability, and tunable mechanical properties, showing great potential in biomedical applications. Using chemical modification to alter the primary structure of silk fibroin enables the expanded generation of new silk‐based biomaterials. Inspired by the molecular structure of hyaluronic acid, which is enriched in carboxyl groups, an efficient method with scaling‐up potential to achieve controlled carboxylation of silk fibroin to prepare silk acid (SA) is reported, and the biological properties of SA are further studied. The SA materials show tunable hydrophilicity and enzymatic degradation properties at different carboxylation degrees (CDs). Subcutaneous implantation in mice for up to 1 month reveals that the SA materials with a high CD present enhanced degradation while causing a mild foreign‐body response, including a low inflammatory response and reduced fibrotic encapsulation. Immunofluorescence analysis further indicates that the SA materials show pro‐angiogenesis properties and promote M2‐type macrophage polarization to facilitate tissue regeneration. This implies great promise for SA materials as a new implantable biomaterial for tissue regeneration.
Association of GLP-1 Receptor Agonists with Chronic Obstructive Pulmonary Disease Exacerbations among Patients with Type 2 Diabetes
Authors: Dinah Foer, Zachary H. Strasser, Jing Cui, Katherine N. Cahill, Joshua A. Boyce, Shawn N. Murphy, Elizabeth W. Karlson
Journal: American Journal of Respiratory and Critical Care Medicine (2023)

Patients with chronic obstructive pulmonary disease (COPD) and type 2 diabetes (T2D) have worse clinical outcomes compared with patients without metabolic dysregulation. GLP-1 (glucagon-like peptide 1) receptor agonists (GLP-1RAs) reduce asthma exacerbation risk and improve FVC in patients with COPD.