POS0726 HEALTH RELATED QUALITY OF LIFE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: DATA AND POTENTIAL APPLICATIONS OF THE MEXICAN REGISTER OF LUPUS.
Authors: A. L. Hernández-Ledesma, K. J. Nuñez-Reza, A. Y. Tapia-Atilano, V. Flores-Ocampo, J. E. Villarreal del Moral, T. V. Román-López, S. V. Vera del Valle, D. Domínguez-Zúñiga, E. Torres-Valdez, G. Frontana-Vázquez, S. Alcauter, M. E. Rentería, A. E. Ruíz-Contreras, D. Alpizar-Rodriguez, A. Medina-Rivera
Journal: Annals of the Rheumatic Diseases (2022)

Background Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease, characterized by a wide variety of clinical manifestations, as well as continuous relapses and exacerbation of symptoms. This complex panorama complicates an early and proper diagnosis, treatment, and follow-up of the people with SLE and therefore has a significant impact on their health-related quality of life (HRQoL). Although the importance of assessing HRQoL in SLE has become evident in recent years, in Mexico there is no epidemiological surveillance system nor national registry that conveys this information. Objectives To evaluate health related quality of life (HRQoL) in Mexican individuals with SLE using the data from the Mexican Register of Lupus (Lupus RGMX). Methods The Mexican Lupus Registry (Lupus RGMX) is an ongoing online register. This cohort includes sociodemographic and clinical data of Mexican individuals with SLE. In this study we assessed and compared HRQoL in patients with SLE and a matched control group of Mexican individuals without SLE diagnosis. We estimated QoL using the World Health Organization Quality of Life (WHOQOL-bref) and Short Form-36 (SF36) questionnaires. For both WHOQOL-bref and SF36, higher scores mean better HRQoL. Statistical analysis was performed using R 4.1.2 (R Core Team, 2021). Results A total of 631 SLE and 272 control registers were analyzed (Table 1). Significant lower scores on HRQoL were observed on participants with SLE for both SF36 and WHOQOL-bref questionnaires, compared with the matched control group. All score components were lower in SLE individuals. Physical role functioning, bodily pain and general health exhibited the lowest scores among the SF36 factors, whereas physical factor was the lowest for WHOQOL-bref (Table 1). Table 1. SF36 and WHOQOL-bref median scores (25-75 IQR) of SLE participants and controls. Controls SLE p-value (n=272) (n=631) Female sex 211 (77.6%) 596 (94.4%) &lt;0.001 n (%)# Age* 28 (24-35) 35 (28-43) &lt;0.001 SF36 (max 100 points per function ) * Physical functioning 100 (95-100) 65 (45-85) &lt;0.001 Physical role functioning 100 (100-100) 25 (0-100) &lt;0.001 Bodily pain 84 (61-100) 31 (22-52) &lt;0.001 General health 77 (62-100) 35 (20-47) &lt;0.001 Vitality 65 (50-100) 40 (25-55) &lt;0.001 Social functioning 100 (62.5-100) 50 (37.5-75) &lt;0.001 Emotional role functioning 100 (66.7-100) 66.7 (0-100) &lt;0.001 Mental health 76 (60-100) 56 (42-74) &lt;0.001 WHOQOL-bref (max 20 points per function ) * Physical 16.6 (14.8-17.7) 11.4 (9.1-13.1) &lt;0.001 Psychological 15.3 (13.3-19.3) 12.7 (10.7-14.7) &lt;0.001 Social relations 14.7 (12-16) 12 (9.3-14.7) &lt;0.001 Environmental 15.5 (14-17) 13 (11-15) &lt;0.001 # Chi-square test, *U Mann-Whitney test Conclusion In Mexican people with SLE, a significant decrease in HRQoL was detected compared with controls. The implementation of a national register in Mexico (Lupus RGMX) will provide additional psychosocial and clinical information to deepen our knowledge of this disease. References [1]Louthrenoo, W., et al. Arthritis Res Ther 2020; 22, 8. [2]Shi Y, et al. Autoimmun Rev. 2021 Jan;20(1):102691. Acknowledgements ALHL is a doctoral student from Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México (UNAM) and recieved fellowship 790972 from CONACYT (CVU 711015). AMR was supported by CONACYT-FORDECYT-PRONACES grant no [11311], and Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica-Universidad Nacional Autónoma de México (PAPIIT-UNAM) grant nos. IA203021 Disclosure of Interests Ana Laura Hernández-Ledesma: None declared, Karen Julia Nuñez-Reza: None declared, Andrea Yojany Tapia-Atilano: None declared, Víctor Flores-Ocampo: None declared, Juan Ernesto Villarreal del Moral: None declared, Talía V. Román-López: None declared, Sandra Valentina Vera del Valle: None declared, Donaji Domínguez-Zúñiga: None declared, Estefania Torres-Valdez: None declared, Gabriel Frontana-Vázquez: None declared, Sarael Alcauter: None declared, Miguel Enrique Rentería: None declared, Alejandra Evelyn Ruíz-Contreras: None declared, Deshire Alpizar-Rodriguez Consultant of: Scientific advisor GKS, Alejandra Medina-Rivera: None declared