tbuckley/cabot-search huggingface dataset:
Changing Ratio of Breast Cancer Incidence Rates With Age of Black Females Compared With White Females in the United States&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Gregory E. Gray, Brian E. Henderson
 4, Malcolm C. Pike
Journal: JNCI Journal of the National Cancer Institute (1980)

Age-standardized breast cancer rates were approximately 30% lower in U.S. black women compared to white women. This observation concealed the fact that black women under age 40 years had a higher incidence of breast cancer than did white women, whereas white women over 40 years had a higher incidence. The known risk factors for breast cancer development (early age at menarche, late age at first full-term delivery, and a late age of menopause) differed in black and white populations, which might explain this difference in breast cancer incidence between blacks and whites at different ages.
Adverse Effects of Niacin In Emergent Psychosis
Authors: A. Hoffer
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Drs. Heninger and Bowers (<b>204</b>:1010, 1968) make a series of false assertions inexcusable in the year 1968. The most flagrant is their statement: "Even though the claims of successful niacin therapy in schizophrenia have not received independent support..." On the contrary, there has been a good deal of support. At least half a dozen private psychiatric hospitals have used the mega vitamin B<sub>3</sub>approach for up to ten years and the number of psychiatrists using it in their practice is growing quickly (<i>J Schizo</i><b>2</b>:3, 1967). A critic may maintain all these investigators were naive or foolish or deluded or had an extraordinary placebo effect upon their patients but he can not truthfully say there has been no independent support. Drs. Heninger and Bowers obviously do not demand double-blind experiments since they make sweeping claims based upon two cases in which treatment or self-treatment
Studies of Japanese Migrants. I. Mortality From Cancer and Other Diseases Among Japanese in the United States
Authors: William Haenszel, Minoru Kurihara
Journal: JNCI Journal of the National Cancer Institute (1968)

Cancer mortality among U.S. Japanese for 1959–1962, emphasizing contrasts of Issei-Nisei experience, is reviewed and compared with earlier findings. Japanese migrant experience concerning displacements in cancer risk appears generally consistent with that of other groups migrating to the United States. Stomach cancer mortality rates among Issei and Nisei are more closely aligned to the high rates in Japan than to the low rates in the United States. On the other hand, mortality rates for cancer of the colon among Japanese (particularly males) have risen almost to equal the higher risks prevailing for U.S. whites. An atypical feature of Japanese migrant experience was the persistence among Issei and Nisei females of the low breast-cancer risks characteristic of Japan, with no apparent tendency to rise to the host population level. Mortality from all causes was low among U.S. Japanese—approximately 30% lower than for whites. This can be traced to the change from high mortality from cerebrovascular accidents in Japan to low mortality in the United States, which more than offsets an increase in deaths from arteriosclerotic heart disease.
Promotion of Smooth Surface Tumorigenicity by Phorbol Myristate Acetate in Balb/3T3 Cells and Balb/3T3 T Proadipocytes&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn3"&gt;3&lt;/xref&gt;
Authors: Robert E. Scott, Charles W. Boone
Journal: JNCI Journal of the National Cancer Institute (1981)

In vitro exposure of Balb/3T3 cells to phorbol and phorbol myristate acetate significantly increased their tumorigenic potential when implanted sc on smooth surface plates into syngeneic mice. This finding supports the hypothesis that many so-called normal cell lines may actually represent initiated cells that can be induced to become tumorigenic following exposure to promoting agents. Since the tumorigenic potential of many tissues in vivo is inversely proportional to the state of differentiation of the stem cell populations undergoing transformation, we assayed the relative tumorigenicity of Balb/3T3 T proadipocytes, which can differentiate in culture, and Balb/3T3 cells, which cannot differentiate in culture. The effects of tumor-promoting agents on these cells were also tested. Plate-implanted Balb/3T3 T proadipocytes were markedly less tumorigenic than Balb/3T3 cells, and Balb/3T3 T proadipocytes were not sensitive to the promotional effects of phorbol myristate acetate.
Possible Scientific Fraud Questions Prompt Debate Over Which Federal Office(s) Should Investigate
Authors: Charles Marwick
Journal: JAMA (1991)

THE ARTICLE was published more than 5 years ago (Weaver D. et al.<i>Cell</i>. 1986;45:247-259). The 6 authors of the report (on the effect of foreign gene transplantation on the murine immune system) included one of the most prominent and, it is generally agreed, most talented biomedical researchers in the United States, Nobel laureate David Baltimore, PhD. Baltimore's name is listed fifth among the authors, following those of David Weaver, PhD (apparently responsible for molecular data in the article, for expression at the RNA level of the transgene, and for sequencing of DNA from the hybridomas); Moema H. Reis, PhD, and Christopher Albanese, PhD (who apparently made immunology contributions); and Frank Costantini, PhD. At the time the report was published, Baltimore—who now is president of Rockefeller University, New York, NY—was director of the Whitehead Institute for Biomedical Research at the Massachusetts Institute of Technology (MIT) in Cambridge. The work reported
Splenectomy, Steroids, and Dextran 70 in Thrombotic Thrombocytopenic Purpura
Authors: Janet Cuttner
Journal: JAMA (1974)

Splenectomy was performed on six patients with thrombotic thrombocytopenic purpura as soon as the diagnosis was established. This procedure was followed by therapy with corticosteroids and dextran 70. Five of six patients are alive four months to four years after diagnosis. Since other means of therapy have resulted, at best, in 31 long-term survivors in more than 300 patients, we believe splenectomy, concomitant therapy with dextran 70 for two weeks, and corticosteroids in gradually decreasing doses for several months show great promise.
Reporting adverse drug reactions
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Value of Plasma α-1-Acid Glycoprotein Assay in the Detection of Human Colorectal Cancer: Comparison with Carcinoembryonic Antigen&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Clement Y-T. Chu, M.D., Lilian T-Y. Lai, M.S., Hari P. Pokala, M.D.
Journal: JNCI Journal of the National Cancer Institute (1982)

Plasma specimens assessed for carcinoembryonic antigen (CEA) in the clinical laboratory for the detection of colorectal cancer were simultaneously assayed in our laboratory for α-1-acid glycoprotein (α1AG), by means of a solid-phase enzyme-linked immunosorbent assay we developed. In 28 patients with colorectal cancer of Dukes A, B, and C classes, elevated levels of α1AG were seen in 12 and of CEA in 8. In 44 patients with distant metastasis (Dukes D lesions), elevated plasma levels of α1AG were seen in 29 and of CEA in 34. No statistical differences in the detection rate were found among these markers in these 2 groups of patients. In 33 cases of non-neoplastic disease involving the large bowel, elevated plasma levels of α1AG were seen in 6, and elevated CEA levels were seen in 7. There was no statistical difference of false positive rates among these two markers. Elevated plasma levels of either CEA or α1AG were found in 57 cases of colorectal cancer. This preliminary study suggests that the sensitivity of the plasma α1AG assay is similar to that of the CEA assay in the detection of colorectal cancer. The combination of these two assays increases the detection rate of colorectal cancer significantly.
Сложный вопрос гепатологии — вирусный гепатит и беременность
Authors: O.N. Vlasova
Journal: GASTROENTEROLOGY (2013)

В статье представлены современные данные относительно особенностей течения хронического вирусного гепатита у беременных. Описана стратегия ведения женщин в этот период, схема обследования. Рассмотрены основные риски инфицирования ребенка, осложнения течения беременности, профилактика заражения новорожденных и их скрининг.
Hepatic Changes After Jejunoileal Bypass
Authors: A. Thomas Marubbio
Journal: JAMA (1982)

<h3>To the Editor.—</h3> In regard to the letter from Carl M. Sutherland et al (1982; 248:171) entitled "Hepatic Toxicity From Adjuvant Chemotherapy After Small-Bowel Bypass," it has been known for some time<sup>1</sup>that morbid obesity is associated with an increase in collagen found in the liver, especially in the central areas pericellularly and in the space of Disse by electron microscopy. After jejunoileal bypass, this fibrosis is severely increased and develops into micronodular cirrhosis in some persons. Most of the time, this micro-nodular cirrhosis is asymptomatic and is found primarily on biopsy. Most patients who have had liver failure secondary to the jejunoileal bypass do so within the first year after surgery, which is unrelated to development of cirrhosis. Thereafter, the patients seem to do well. It is not surprising that if this "silent" micro-nodular cirrhosis is an established event, treatment with hepatotoxic agents several years after the jejunoileal
Problems of Psychoanalytic Technique
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transesophageal Echocardiography
Authors: K Groundstroem
Journal: New England Journal of Medicine (1995)

The Council on Scientific Affairs of the California Medical Association presents the following inventory of items of progress in anesthesiology. Each item, in the judgment of a panel of knowledgeable physicians, has recently become reasonably firmly established, both as to scientific fact and important clinical significance. The items are presented in simple epitome, and an authoritative reference, both to the item itself and to the subject as a whole, is generally given for those who may be unfamiliar with a particular item. The purpose is to assist busy practitioners, students, researchers, and scholars to stay abreast of these items of progress in anesthesiology, that have recently achieved a substantial degree of authoritative acceptance, whether in their own field of special interest or another. The items of progress listed below were selected by the Advisory Panel to the Section on Anesthesiology of the California Medical Association, and the summaries were prepared under its direction.
Choice of Steroid For Treatment of Drug Hypersensitivity
Authors: R. Brian Smith
Journal: JAMA (1972)

<h3>To the Editor.—</h3> The recent article entitled "Sudden Appearance of Cardiac Arrhythmias" by Schmidt et al<sup>1</sup>brought to our attention that one of the preservatives in dexamethasone (Decadron) is methylparaben. Methyl and propyl parabens are used extensively as preservatives in local anesthetics and parenteral penicillin preparations. These drugs can cause hypersensitivity reactions. Paraben allergies have already been cited as a cause of intractable dermatitis by Schorr.<sup>2</sup>A possible cross-sensitivity between the parabens, which are derivatives of parahydroxybenzoic acid, and structurally related procaine has been postulated by deJong.<sup>3</sup> This raises the question of choice of steroid preparation that should be used for the treatment of hypersensitivity reactions. Many injectable preparations of steroids contain parabens and it would seem advisable to select one that does not. If a hypersensitivity reaction is due to a preservative, then addition of more of this preservative with a steroid would be inappropriate. Perhaps
Electrocardiographic Artifacts Caused by Defective Marker Circuitry
Authors: William C. James
Journal: JAMA (1982)

<h3>To the Editor.—</h3> Interpretation of ECG is complicated by a variety of artifacts caused by disturbances such as broken lead wires (1972;220:1130; 1973;223:439) and transposed lead wires (1979;242:617), muscle tremors, seizures and hiccups,<sup>1,2</sup>arteriovenous fistula (1979;241:2380), intravenous infusion devices,<sup>3,4</sup>malfunction of an electric watch (1974;228:26), and a pacemaker pulse-width controller.<sup>5</sup>Reported here is an artifact resembling an intermittent atrial flutter caused by defective marker circuitry of an ECG machine. <h3>Report of a Case.—</h3> A 48-year-old man experienced the onset of chest pain while playing tennis and was brought to the emergency room of the Maui Memorial Hospital. An ECG was obtained, and the physician on duty reviewed the strip before mounting the lead samples onto an ECG form. Although there was no evidence of ischemia or infarction, the physician observed what appeared to be P waves in rapid irregular bursts (Figure) and arranged admission to the coronary care
Cystic Disease of the Renal Medulla in the Elderly
Authors: Robert S. Swenson
Journal: JAMA (1974)

A 68-year-old woman with uremia and "renal salt wasting" improved greatly with sodium repletion. Several family members had died of renal failure. Multiple, bilateral corticomedullary cysts were seen on high-dose excretory urography with nephrotomography. A 67-year-old brother with normal urinalysis and creatinine clearance values also showed corticomedullary cysts on excretory urography. Despite long-term sodium supplementation, uremia progressed inexorably and death occurred 3 1/4 years after clinical onset of disease. Cystic disease of the renal medulla was confirmed at time of autopsy. The triad of a positive family history, renal salt wasting, and progressive chronic uremia strongly suggests the diagnosis of cystic disease of the renal medulla, irrespective of the age of the patient. (<i>JAMA</i>228:1401-1404, 1974)
Officers and Committees
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prophylaxis of Postoperative Deep Venous Thrombosis
Authors: P. Wille-Jørgensen
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The results of a multicenter trial of dihydroergotamine-heparin in the prophylaxis of postoperative deep vein thrombosis<sup>1</sup>concluded that a combination of dihydroergotamine mesylate, 0.5 mg, and heparin sodium, 5,000 IU, given subcutaneously twice daily, is superior to low-dose heparin alone. The criterion for deep vein thrombosis was a positive radiofibrinogen uptake test (RFUT) finding. We have reported the results of a randomized trial, based on 181 patients who underwent major abdominal surgery, comparing dihydroergotamine-heparin<i>v</i>heparin as prophylaxis for deep vein thrombosis.<sup>2</sup>We employed the RFUT as a screening procedure. Patients with a positive RFUT finding were subjected to ascending phlebography. The criterion for deep vein thrombosis was an abnormal phlebogram. There were two false-positive results for RFUTs in the patient group receiving dihydroergotamine-heparin and 11 false-positive results in the group given heparin only. Abnormal results of the RFUT were significantly more frequent in the heparin
Responses of Canine Lymphocytes to Allogeneic and Autologous Islets of Langerhans in Mixed Cell Cultures
Authors: Alexander Rabinovitch, Laphalle Fuller, Daniel Mintz, Walter Severyn, Jack Noel, Cathy Flaa, George Kyriakides, Joshua Miller
Journal: Journal of Clinical Investigation (1981)

Because successful allotransplantation of islets of Langerhans isolated by collagenase digestion has been difficult in many animal species, we asked whether isolated islet preparations might have tissue specific determinants conferring amplified immunogenicity in vitro. Lymphocyte proliferative responses ([3H]thymidine uptake) were studied in beagle dogs in mixed culture combinations of lymphocyte vs. lymphocyte (MLC) and lymphocyte vs. islet (MLIC). In five MLC responder and five nonresponder pairs, peripheral blood lymphocytes of dogs A and B were used as responding cells, and dog B x-irradiated lymphocytes (Bx), x-irradiated (or nonirradiated) islets (BI), or hepatic cells (BH) were used as stimulating cells in primary and secondary reactions. For the secondary reactions, A + Bx, A + BI, or B + BI were incubated for 9 d (A′B, A′BI, B′BI, respectively) before addition of new stimulating cells.
Karyotypic Differences Between Primary Cultures and Cell Lines From Tumors With the Human T-Cell Leukemia Virus&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Peter C. Nowell, Janet B. Finan, Jeffrey W. Clark, Prem S. Sarin, Robert C. Gallo
Journal: JNCI Journal of the National Cancer Institute (1984)

Chromosome abnormalities were studied in primary cultures and in established T-cell lines from patients with human T-cell leukemia virus (HTLV)-positive leukemia or lymphoma. The present findings, and data from other laboratories, indicated that primary cultures of the HTLV-positive neoplastic cells nearly always showed a chromosomally abnormal clone, whereas most established cell lines had an apparently normal karyotype. These differences included circumstances in which the same blood specimen was used for both types of culture or in which separate specimens were obtained within a short time span. These observations indicated that many cell lines from HTLV-positive leukemia or lymphoma may be derived from nonneoplastic T-cells that were transformed in vitro by the leukemia virus; human T-cells newly infected with HTLV were suggested to have an in vitro growth advantage over the HTLV-infected tumor cells.
Evidence for the Antigenicity of Papillomas Induced by 3-Methylcholanthrene&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Lappé, Marc A.
Journal: JNCI Journal of the National Cancer Institute (1968)

Journal Article Evidence for the Antigenicity of Papillomas Induced by 3-Methylcholanthrene Get access Marc A. Lappé Marc A. Lappé The Institute for Cancer Research, Philadelphia, Pennsylvania 19111 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 40, Issue 4, April 1968, Pages 823–846, https://doi.org/10.1093/jnci/40.4.823 Published: 01 April 1968 Article history Received: 14 September 1967 Accepted: 21 November 1967 Published: 01 April 1968
Rarity of Transient Focal Cerebral Ischemia in Cardiac Dysrhythmia
Authors: Robert L. Reed
Journal: JAMA (1973)

Transient focal cerebral ischemic attacks are rare in patients who have episodes of cardiac dysrhythmias of the type associated with significant reduction in cardiac output. Of 290 patients who received pacemakers for disturbances of cardiac rhythm or conduction, only four had focal neurologic symptoms or signs, and only two (1%) had focal cerebral symptoms that could be related to a specific episode of cardiac dysfunction. The vast majority of the 290 patients had symptoms of general cerebral ischemia, primarily syncope.
Mutagenic Activity of Nitrosourea Antitumor Agents&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN4"&gt;4&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1980)

Journal Article Mutagenic Activity of Nitrosourea Antitumor Agents Get access B. Robert Franza, Jr., B. Robert Franza, Jr. Search for other works by this author on: Oxford Academic PubMed Google Scholar Nicole S. Oeschger, Nicole S. Oeschger Search for other works by this author on: Oxford Academic PubMed Google Scholar Max P. Oeschger, Max P. Oeschger Search for other works by this author on: Oxford Academic PubMed Google Scholar Philip S. Schein Philip S. Schein 8 8Address reprint requests to Dr. Schein. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 65, Issue 1, July 1980, Pages 149–154, https://doi.org/10.1093/jnci/65.1.149 Published: 01 July 1980 Article history Received: 03 August 1979 Revision received: 12 February 1980 Accepted: 19 February 1980 Published: 01 July 1980