tbuckley/cabot-search huggingface dataset:
TCT-149 Does the Involvement of Left Circumflex Coronary Artery Ostium Affect Prognosis in Patients Undergoing Percutaneous Coronary Intervention for Left Main Disease?
Authors: Wojciech Skorupski, Marta Kaluzna-Oleksy, Przemyslaw Mitkowski, Aleksander Araszkiewicz, Malgorzata Pyda, Stefan Grajek, Wlodzimierz Skorupski, Michał Lesiak, Sylwia Iwanczyk, Stanislaw Jankiewicz, Maciej Lesiak, Marek Grygier
Journal: Journal of the American College of Cardiology (2022)
TCT-167 Percutaneous Coronary Intervention With Ultrathin-Strut Biodegradable Versus Thin-Strut Durable Polymer Drug-Eluting Stents of Lesions Requiring Multiple Stents: A Lesion-Level Subgroup Analysis of the Combined BIOSCIENCE and BIOSTEMI Randomized Trials
Authors: Jonas Haener, Miklos Rohla, Juan F. Iglesias, Olivier Muller, Eric Eeckhout, David Kurz, Daniel Weilenmann, Christoph Kaiser, Maxime Tapponnier, Marco Roffi, Dik Heg, Stephan Windecker, Thomas Pilgrim
Journal: Journal of the American College of Cardiology (2022)
TCT-142 Treatment of In-Stent Restenosis With the Use of a Dedicated Super High-Pressure Balloon
Authors: Thomas Seiler, Adrian Attinger-Toller, Giacomo Maria Cioffi, Mehdi Madanchi, Gregorio Tersalvi, Federico Moccetti, Stefan Toggweiler, Richard Kobza, Matthias Bossard, Florim Cuculi
Journal: Journal of the American College of Cardiology (2022)
TCT-151 Dual Antiplatelet Therapy After Percutaneous Coronary Intervention for Left Main Coronary Artery Disease
Authors: Sungsoo Cho, Do-Yoon Kang, Jung-Sun Kim, Duk-Woo Park, In-Soo Kim, Tae Soo Kang, Jung-Min Ahn, Pil Hyung Lee, Soo-Jin Kang, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Yong-Joon Lee, Seung-Jun Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Yangsoo Jang, Myeong-Ki Hong, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2022)
TCT-171 Predicting the Risk of Perforation Requiring Pericardiocentesis in Chronic Total Occlusion Percutaneous Coronary Intervention: The PROGRESS-CTO Pericardiocentesis Score
Authors: Bahadir Simsek, Spyridon Kostantinis, Judit Karacsonyi, Khaldoon Alaswad, Oleg Krestyaninov, Dmitrii Khelimskii, Rhian Davies, Jeremy Rier, Omer Goktekin, Sevket Gorgulu, Ahmed ElGuindy, Raj Chandwaney, Mitul Patel, Dimitri Karmpaliotis, Jaikirshan Khatri, Farouc Jaffer, Paul Poommipanit, Bavana Rangan, Yader Sandoval, Basem Elbarouni, William Nicholson, Stephane Rinfret, Michail Koutouzis, Ioannis Tsiafoutis, Robert Yeh, M. Nicholas Burke, Salman Allana, Olga Mastrodemos, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2022)
TCT-163 A 9-Month Randomized Comparison of Healing of Biolimus and Everolimus Drug-Eluting Stents in Patients With STEMI: Long-Term (5-Years) Clinical Follow-Up
Authors: Martin Jakl, Jan Kanovsky, Radim Spacek, Martin Kvasnak, Michaela Cervinkova, Guilherme Attizzani, Pavel Cervinka
Journal: Journal of the American College of Cardiology (2022)
TCT-137 Contribution of Plaque Composition to the Extent of Plaque Fracture and Dissection Following Drug-Coated Balloon Angioplasty in De Novo Small Vessel Disease: An Interim Report of the TRANSFORM-I Trial
Authors: Kai Ninomiya, Patrick Serruys, Jiayue Huang, Shinichiro Masuda, Daixin Ding, Manish Doshi, Shengxian Tu, Jouke Dijkstra, Roberto Nerla, Carlo di Mario, Luca Testa, Bernardo Cortese, Sandeep Basavarajaiah, Antonio Colombo, Faisal Sharif, Yoshinobu Onuma
Journal: Journal of the American College of Cardiology (2022)
TCT-175 Safety and Complications Associated With the Use of Protamine in Percutaneous Coronary Intervention
Authors: Hussayn Alrayes, Ayman Alsaadi, Ahmad Alkhatib, Dhruvil Patel, Mohammad Alqarqaz, Tiberio Frisoli, Brittany Fuller, Akshay Khandelwal, Gerald Koenig, Brian O’Neill, Pedro Villablanca, Mohammad Zaidan, William O’Neill, Khaldoon Alaswad, Mir Basir
Journal: Journal of the American College of Cardiology (2022)
TCT-161 Evaluation of Effectiveness and Safety of Ultimaster Stent in Routine Clinical Practice; A Multicenter, Prospective, Observational Study
Authors: Seung-Woon Rha, Sang Yeub Lee, Se Yeon Choi, Jae Kyeong Byun, Jinah Cha, Dong Oh Kang, Ji Bak Kim, Eung Ju Kim
Journal: Journal of the American College of Cardiology (2022)
TCT-140 Relationship Between In-Stent Restenosis, Excessive Skin Healing, and Patient’s Immunologic Profile
Authors: Iñigo Lozano, Roi Bangueses, Isabel Rodriguez, Marta Lopez, Raul Rodríguez-Aguilar, Martina Espasandin-Arias, Sara Llames, Javier Rodriguez
Journal: Journal of the American College of Cardiology (2022)
TCT-144 Laminar Flow After Stenting Assured No Early Thrombosis nor Late In-Stent Restenosis: An Angiographic Machine Learning Analysis and Personalized Medicine Approach
Authors: Phuc Vu, Wei Hsu, Miguel Marques Antunes, Thien Pham, Loc Vu, Nghi Tran, Sarthak Aggarwal, Imran Mihas, Saanya Agarwal, Thach Nguyen, Phong Phan
Journal: Journal of the American College of Cardiology (2022)
TCT-154 Comparison of Szabo 2-Stent Technique With T and Protrusion (TAP) and T Stenting Techniques Within Reanimated Swine Hearts: Via Visible Heart® Methodologies
Authors: Stefano Cangemi, Amanda DeVos, Michael Bielecki, Francesco Bianchini, Paul Iaizzo
Journal: Journal of the American College of Cardiology (2022)
TCT-136 Use of Sirolimus-Coated Balloon in De Novo Small-Vessel Coronary Lesions in Acute Coronary Syndrome: Long-Term Follow-Up From a Single-Center Registry
Authors: Maria Zakai, Bhagya Loku Waduge, Waseem Raja, Sampath Athukorala, Richard Watkin, Nitin Kumar, Bethan Freestone, George Pulikal, Sandeep Basavarajaiah
Journal: Journal of the American College of Cardiology (2022)
Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis: a randomised, double-blind, placebo-controlled, phase 3 trial
Authors: Amy S Paller, Eric L Simpson, Elaine C Siegfried, Michael J Cork, Andreas Wollenberg, Peter D Arkwright, Weily Soong, Mercedes E Gonzalez, Lynda C Schneider, Robert Sidbury, Benjamin Lockshin, Steven Meltzer, Zhixiao Wang, Leda P Mannent, Nikhil Amin, Yiping Sun, Elizabeth Laws, Bolanle Akinlade, Myles Dillon, Matthew P Kosloski, Mohamed A Kamal, Ariane Dubost-Brama, Naimish Patel, David M Weinreich, George D Yancopoulos, John T O’Malley, Ashish Bansal, Amber Pepper, Amy S Paller, Benjamin Lockshin, David Cohen, David Pariser, Elaine C Siegfried, Eric L Simpson, Jeffrey Leflein, Jeffrey Weinberg, John Browning, Joyce Teng, Lara Wine Lee, Lawrence Sher, Lucia Diaz, Lynda Schneider, Mercedes E Gonzalez, Ned Rupp, Peck Ong, Robert Cartwright, Robert Sidbury, Weily Soong, Andreas Pinter, Andreas Wollenberg, Christina Schnopp, Michael J Cork, Peter D Arkwright, Anna Korkosz, Dorota Bystrzanowska, Ewa Sygula, Jacek Zdybski, Kamila Padlewska
Journal: The Lancet (2022)
Linzagolix with and without hormonal add-back therapy for the treatment of symptomatic uterine fibroids: two randomised, placebo-controlled, phase 3 trials
Authors: Jacques Donnez, Hugh S Taylor, Elizabeth A Stewart, Linda Bradley, Erica Marsh, David Archer, Ayman Al-Hendy, Felice Petraglia, Nelson Watts, Jean-Pierre Gotteland, Elke Bestel, Paul Terrill, Ernest Loumaye, Andrew Humberstone, Elizabeth Garner
Journal: The Lancet (2022)
The impact of war on the environment and health: implications for readiness, response, and recovery in Ukraine
Authors: Francesca Racioppi, Harry Rutter, Dorit Nitzan, Anja Borojevic, Zhanat Carr, Tanya Jean Grygaski, Dorota Jarosińska, Sinaia Netanyahu, Oliver Schmoll, Karien Stuetzle, Amber Van Den Akker, Hans Henri P Kluge
Journal: The Lancet (2022)
Lung cell entry, cell–cell fusion capacity, and neutralisation sensitivity of omicron sublineage BA.2.75
Authors: Prerna Arora, Inga Nehlmeier, Amy Kempf, Anne Cossmann, Sebastian R Schulz, Alexandra Dopfer-Jablonka, Eva Baier, Björn Tampe, Onnen Moerer, Steffen Dickel, Martin S Winkler, Hans-Martin Jäck, Georg M N Behrens, Stefan Pöhlmann, Markus Hoffmann
Journal: The Lancet Infectious Diseases (2022)
Advanced Robotics to Address the Translational Gap in Tendon Engineering
Authors: Iain L. Sander, Nicole Dvorak, Julie A. Stebbins, Andrew J. Carr, Pierre-Alexis Mouthuy
Journal: Cyborg and Bionic Systems (2022)

Tendon disease is a significant and growing burden to healthcare systems. One strategy to address this challenge is tissue engineering. A widely held view in this field is that mechanical stimulation provided to constructs should replicate the mechanical environment of native tissue as closely as possible. We review recent tendon tissue engineering studies in this article and highlight limitations of conventional uniaxial tensile bioreactors used in current literature. Advanced robotic platforms such as musculoskeletal humanoid robots and soft robotic actuators are promising technologies which may help address translational gaps in tendon tissue engineering. We suggest the proposed benefits of these technologies and identify recent studies which have worked to implement these technologies in tissue engineering. Lastly, key challenges to address in adapting these robotic technologies and proposed future research directions for tendon tissue engineering are discussed.
Efficacy of Biological and Physical Enhancement on Targeted Muscle Reinnervation
Authors: Siyang Zhong, Zijun Zhang, Huan Su, Chenyang Li, Yifeng Lin, Wei Lu, Zhendong Jiang, Lin Yang
Journal: Cyborg and Bionic Systems (2022)

Targeted muscle reinnervation (TMR) is a microsurgical repair technique to reconstruct the anatomical structure between the distal nerve and the muscle stump to provide more myoelectric information to the artificially intelligent prosthesis. Postoperative functional electrical stimulation treatment of the patient’s denervated muscle or proximal nerve stump as well as nerve growth factor injection is effective in promoting nerve regeneration and muscle function recovery. In this experiment, we successfully established a TMR rat model and divided Sprague-Dawley (SD) adult male rats into TMR group, TMR + FES group, and TMR + NGF group according to TMR and whether they received FES treatment or NGF injection after surgery, and the recovery effect of rat neuromuscular function was assessed by analyzing EMG signals. Through the experiments, we confirmed that growth factor supplementation and low-frequency electrical stimulation can effectively promote the regeneration of the transplanted nerve as well as significantly enhance the motor function of the target muscle and have a positive effect on the regeneration of the transplanted nerve.
Derivation and External Validation of a Clinical Model to Predict Heart Failure Onset in Patients With Incident Diabetes
Authors: Louise Y. Sun, Salwa S. Zghebi, Anan Bader Eddeen, Peter P. Liu, Douglas S. Lee, Karen Tu, Sheldon W. Tobe, Evangelos Kontopantelis, Mamas A. Mamas
Journal: Diabetes Care (2022)

Heart failure (HF) often develops in patients with diabetes and is recognized for its role in increased cardiovascular morbidity and mortality in this population. Most existing models predict risk in patients with prevalent rather than incident diabetes and fail to account for sex differences in HF risk factors. We derived sex-specific models in Ontario, Canada to predict HF at diabetes onset and externally validated these models in the U.K.Retrospective cohort study using international population-based data. Our derivation cohort comprised all Ontario residents aged ≥18 years who were diagnosed with diabetes between 2009 and 2018. Our validation cohort comprised U.K. patients aged ≥35 years who were diagnosed with diabetes between 2007 and 2017. Primary outcome was incident HF. Sex-stratified multivariable Fine and Gray subdistribution hazard models were constructed, with death as a competing event.A total of 348,027 Ontarians (45% women) and 54,483 U.K. residents (45% women) were included. At 1, 5, and 9 years, respectively, in the external validation cohort, the C-statistics were 0.81 (95% CI 0.79-0.84), 0.79 (0.77-0.80), and 0.78 (0.76-0.79) for the female-specific model; and 0.78 (0.75-0.80), 0.77 (0.76-0.79), and 0.77 (0.75-0.79) for the male-specific model. The models were well-calibrated. Age, rurality, hypertension duration, hemoglobin, HbA1c, and cardiovascular diseases were common predictors in both sexes. Additionally, mood disorder and alcoholism (heavy drinker) were female-specific predictors, while income and liver disease were male-specific predictors.Our findings highlight the importance of developing sex-specific models and represent an important step toward personalized lifestyle and pharmacologic prevention of future HF development.
Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury
Authors: Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci
Journal: Hepatology (2022)

Drug-induced liver injury (DILI) is a common disorder that involves both direct liver cell toxicity and immune activation. The bile acid receptor, G-protein-coupled bile acid receptor 1 (GPBAR1; Takeda G-protein-coupled receptor 5 [TGR5]), and cysteinyl leukotriene receptor (CYSLTR) 1 are G-protein-coupled receptors activated by bile acids and leukotrienes, exerting opposite effects on cell-to-cell adhesion, inflammation, and immune cell activation. To investigate whether GPBAR1 and CYSLTR1 mutually interact in the development of DILI, we developed an orally active small molecule, CHIN117, that functions as a GPBAR1 agonist and CYSLTR1 antagonist.RNA-sequencing analysis of liver explants showed that acetaminophen (APAP) intoxication positively modulates the leukotriene pathway, CYSLTR1, 5-lipoxygenase, and 5-lipoxygenase activating protein, whereas GPBAR1 gene expression was unchanged. In mice, acute liver injury induced by orally dosing APAP (500 mg/kg) was severely exacerbated by Gpbar1 gene ablation and attenuated by anti-Cysltr1 small interfering RNA pretreatment. Therapeutic dosing of wild-type mice with CHIN117 reversed the liver damage caused by APAP and modulated up to 1300 genes, including 38 chemokines and receptors, that were not shared by dosing mice with a selective GPBAR1 agonist or CYSLTR1 antagonist. Coexpression of the two receptors was detected in liver sinusoidal endothelial cells (LSECs), monocytes, and Kupffer cells, whereas combinatorial modulation of CYSLTR1 and GPBAR1 potently reversed LSEC/monocyte interactions. CHIN117 reversed liver damage and liver fibrosis in mice administered CCl 4 .By genetic and pharmacological approaches, we demonstrated that GPBAR1 and CYSLTR1 mutually interact in the development of DILI. A combinatorial approach designed to activate GPBAR1 while inhibiting CYSLTR1 reverses liver injury in models of DILI.
PD-1/PD-L1 blockade is a potent adjuvant in treatment of Staphylococcus aureus osteomyelitis in mice
Authors: Kaiqun Li, Yuhui Chen, Yihuang Lin, Guangyan Zhang, Jianwen Su, Xiaohu Wu, Caiyu Cheng, Yutian Wang, Bin Yu, Xianrong Zhang
Journal: Molecular Therapy (2022)

There is no effective therapy for implant-associated Staphylococcus aureus osteomyelitis, a devastating complication after orthopedic surgery. An immune-suppressive profile with up-regulated programmed cell death 1/programmed death ligand 1 (PD-1/PD-L1) was identified based on our transcriptional data (GEO: GSE166522) from a mouse model of S. aureus osteomyelitis. PD-1/PD-L1 expression was up-regulated mainly in F4/80
Randomized Phase II Study of Physiologic MRI-Directed Adaptive Radiation Boost in Poor Prognosis Head and Neck Cancer
Authors: Michelle L. Mierzwa, Madhava Aryal, Choonik Lee, Matthew Schipper, Monica VanTil, Krystal Morales, Paul L. Swiecicki, Keith A. Casper, Kelly M. Malloy, Matthew E. Spector, Andrew G. Shuman, Steven B. Chinn, Mark E.P. Prince, Chaz L. Stucken, Andrew J. Rosko, Theodore S. Lawrence, J. Chad Brenner, Benjamin Rosen, Caitlin A. Schonewolf, Jennifer Shah, Avraham Eisbruch, Francis P. Worden, Yue Cao
Journal: Clinical Cancer Research (2022)

Abstract Purpose: We conducted a randomized phase II multicenter clinical trial to test the hypothesis that physiologic MRI-based radiotherapy (RT) dose escalation would improve the outcome of patients with poor prognosis head and neck cancer. Patients and Methods: MRI was acquired at baseline and at RT fraction 10 to create low blood volume/apparent diffusion coefficient maps for RT boost subvolume definition in gross tumor volume. Patients were randomized to receive 70 Gy (standard RT) or 80 Gy to the boost subvolume (RT boost) with concurrent weekly platinum. The primary endpoint was disease-free survival (DFS) with significance defined at a one-sided 0.1 level, and secondary endpoints included locoregional failure (LRF), overall survival (OS), comparison of adverse events and patient reported outcomes (PRO). Results: Among 81 randomized patients, neither the primary endpoint of DFS (HR = 0.849, P = 0.31) nor OS (HR = 1.19, P = 0.66) was significantly improved in the RT boost arm. However, the incidence of LRF was significantly improved with the addition of the RT boost (HR = 0.43, P = 0.047). Two-year estimates [90% confidence interval (CI)] of the cumulative incidence of LRF were 40% (27%–53%) in the standard RT arm and 18% (10%–31%) in the RT boost arm. Two-year estimates (90% CI) for DFS were 48% (34%–60%) in the standard RT arm and 57% (43%–69%) in the RT boost arm. There were no significant differences in toxicity or longitudinal differences seen in EORTC QLQ30/HN35 subscales between treatment arms in linear mixed-effects models. Conclusions: Physiologic MRI-based RT boost decreased LRF without a significant increase in grade 3+ toxicity or longitudinal PRO differences, but did not significantly improve DFS or OS. Additional improvements in systemic therapy are likely necessary to realize improvements in DFS and OS.
Proteomic and functional characterization of intra-tumor heterogeneity in human endometrial cancer
Authors: M. Fairuz B. Jamaluddin, Yi-An Ko, Arnab Ghosh, Shafiq M. Syed, Yvette Ius, Rachel O’Sullivan, Jacob K. Netherton, Mark A. Baker, Pravin Nahar, Kenneth Jaaback, Pradeep S. Tanwar
Journal: Cell Reports Medicine (2022)

Endometrial cancer is one of the most frequently diagnosed gynecological cancers worldwide, and its prevalence has increased by more than 50% over the last two decades. Despite the understanding of the major signaling pathways driving the growth and metastasis of endometrial cancer, clinical trials targeting these signals have reported poor outcomes. The heterogeneous nature of endometrial cancer is suspected to be one of the key reasons for the failure of targeted therapies. In this study, we perform a sequential window acquisition of all theoretical fragment ion spectra (SWATH)-based comparative proteomic analysis of 63 tumor biopsies collected from 20 patients and define differences in protein signature in multiple regions of the same tumor. We develop organoids from multiple biopsies collected from the same tumor and show that organoids capture heterogeneity in endometrial cancer growth. Overall, using quantitative proteomics and patient-derived organoids, we define the heterogeneous nature of endometrial cancer within a patient's tumor.
Autoantibodies as Predictors for Clinical Outcome and Toxicity for Immunotherapy
Authors: Jessica C. Hassel, Jason J. Luke
Journal: Clinical Cancer Research (2022)

Summary Peripheral blood autoantibody signatures might be useful biomarkers of immunotherapy outcome. Signatures predicting melanoma recurrence and toxicity during adjuvant immunotherapy were recently presented. Whether autoantibodies are bystanders or have a pathophysiologic role is unknown, and further efforts are needed to investigate potential mechanisms and determine causation. See related article by Johannet et al., p. 4121
<i>QuickStats:</i> Percentage of Total Deaths, by Age and Hispanic Origin and Race*<sup>,</sup><sup>†</sup> — United States, 2020
Authors: Jiaquan Xu
Journal: MMWR Morbidity and Mortality Weekly Report (2022)

Significant differences in the age distribution of deaths by race and ethnicity were observed in the United States during 2020.Decedents aged <65 years accounted for 26% of all U.S. deaths, but they accounted for approximately 50% of deaths among AI/AN and NH/OPI persons, 40% of deaths among Black or African American (Black) and Hispanic or Latino (Hispanic) persons, and 20% of deaths among Asian and White persons.Smaller differences were noted among persons aged 65-84 years.Among persons aged ≥85 years, the pattern was reversed, with the percentage of all deaths ranging from approximately 11% among AI/AN and NH/OPI persons to 33% for Asian and White persons.
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1
Authors: Sheng Chen, Wenyu Cui, Zhexu Chi, Qian Xiao, Tianyi Hu, Qizhen Ye, Kaixiang Zhu, Weiwei Yu, Zhen Wang, Chengxuan Yu, Xiang Pan, Siqi Dai, Qi Yang, Jiacheng Jin, Jian Zhang, Mobai Li, Dehang Yang, Qianzhou Yu, Quanquan Wang, Xiafei Yu, Wei Yang, Xue Zhang, Junbin Qian, Kefeng Ding, Di Wang
Journal: Cell Metabolism (2022)
<scp><i>circS100A11</i></scp> enhances M2a macrophage activation and lung inflammation in children with asthma
Authors: Qiuyan Liang, Jinrong Fu, Xiang Wang, Lijuan Liu, Wenfeng Xiao, Yajing Gao, Lan Yang, Hongmiao Yu, Xueru Xie, Zikun Tu, Saihua Huang, Xiao Han, Liling Qian, Yufeng Zhou
Journal: Allergy (2022)

Dysregulation of circRNAs is associated with a variety of human diseases; however, its role in childhood asthma is undefined.The differential expression profiles of circRNAs were analyzed by microarray. The effects and mechanisms by which circRNAs influence macrophage activation were detected by quantitative real-time PCR, RNA immunoprecipitation assay, and chromatin immunoprecipitation assay, among others. The roles of circRNA and its host gene in asthma were tested in a cockroach allergen extract (CRE)-induced murine asthma model.We identified 372 circRNAs that were differentially expressed in PBMCs of children with asthma as compared with healthy controls. A circRNA with unknown function, circS100A11, was dominantly expressed in monocytes and significantly upregulated in children with asthma. circS100A11 facilitated M2a macrophage activation by enhancing translation of its host gene, S100A11, and exacerbated lung inflammation in a CRE-induced murine asthma model with macrophage-specific overexpression of circS100A11. Mechanistically, circS100A11 promoted S100A11 translation by competitively binding to CAPRIN1 to decrease the suppression of CAPRIN1 upon S100A11 translation. Then, S100A11 liberated SP3 from nucleolin and promoted SP3 binding to the STAT6 promoter to enhance STAT6 expression and M2a macrophage activation. Macrophage-specific knockdown of S100A11 could alleviate lung inflammation in a CRE-induced murine asthma model in vivo.circS100A11 and S100A11 promote M2a macrophage activation and lung inflammation in asthma model and may serve as potential therapeutic and diagnostic targets in children with asthma.