tbuckley/cabot-search huggingface dataset:
Efficacy and Safety of Daratumumab Plus Bortezomib and Dexamethasone in Newly Diagnosed Patients with Mayo 2004 Stage 3 Light-Chain Amyloidosis: A Prospective Phase 2 Study
Authors: Ya-Juan Gao, Kaini Shen, Long Chang, Jun Feng, Yueying Mao, Lu Zhang, Xinxin Cao, Daobin Zhou, Jian Li
Journal: Blood (2022)
Bayesian Inference for Optimization of Interim Analysis in Clinical Trials By Incorporation of Historical Data: Reanalysis of the HOVON AML 132 Clinical Trial
Authors: Niek Van Der Maas, Kazem Nasserinejad, Thomas Pabst, Johan A. Maertens, Dimitri A. Breems, Markus G Manz, Jacqueline Cloos, Gert J. Ossenkoppele, Yngvar Floisand, Patrycja Gradowska, Bob Lowenberg, Gerwin A. Huls, Douwe Postmus, Francesco Pignatti, Jan J. Cornelissen, Jurjen Versluis
Journal: Blood (2022)
Interferon-alpha2 Treatment Reduces Circulating Neutrophil Extracellular Trap Levels in Myeloproliferative Neoplasms
Authors: Laura Massarenti, Trine A. Knudsen, Christian Enevold, Vibe Skov, Lasse Kjær, Morten Kranker Larsen, Claus Henrik Nielsen, Hans Carl Hasselbalch
Journal: Blood (2022)
Life Satisfaction and Quality of Life in AML Long-Term Survivors: Primary Results of the AMLCG-Survivorship Study
Authors: Eva Telzerow, Dennis Görlich, Maria Cristina Sauerland, Anna Sophia Moret, Maja Rothenberg-Thurley, Simon M. Krauss, Friederike H.A. Mumm, Susanne Amler, Wolfgang E. Berdel, Bernhard J. Wörmann, Utz Krug, Jan Braess, Pia Heußner, Wolfgang Hiddemann, Karsten Spiekermann, Klaus H. Metzeler
Journal: Blood (2022)
Teclistamab Population Pharmacokinetics and Exposure-Response Relationship Support 1.5 Mg/Kg Dose Regimen in Relapsed/Refractory Multiple Myeloma
Authors: Xin Miao, Liviawati S. Wu, Shun Xin Wang Lin, Yan Xu, Yang Chen, Yuki Iwaki, Rachel Kobos, Tara Stephenson, Kristy Kemmerer, Clarissa M. Uhlar, Arnob Banerjee, Jenna D. Goldberg, Danielle Trancucci, Raluca Verona, Lixia Pei, Yaming Su, Daniele Ouellet, Alfred L. Garfall, Amrita Y. Krishnan, Saad Usmani, Suzette Girgis, Honghui Zhou
Journal: Blood (2022)
Risk of Infections Associated with the Use of Bispecific Antibodies in Multiple Myeloma: A Pooled Analysis
Authors: Farah Mazahreh, Liyan Mazahreh, Carolina Schinke, Sharmilan Thanendrarajan, Maurizio Zangari, John D Shaughnessy, Fenghuang Zhan, Frits van Rhee, Samer Al Hadidi
Journal: Blood (2022)
Modakafusp Alfa (TAK-573), a Novel CD38-Targeting Attenuated Interferon-Alpha Immunocytokine, Kills MM Cells Via NK Cell Activation
Authors: Wassilis S.C. Bruins, Rosa Rentenaar, Sabrina Collins, James F. Sampson, Niels WCJ Van De Donk, Sonja Zweegman, Tuna Mutis
Journal: Blood (2022)
Acute Pulmonary Embolism and Cancer: Clinical Features, Management and Short-Term Course. Findings from the COPE Study
Authors: Cecilia Becattini, Ludovica Anna Cimini, Giorgio Bassanelli, Aldo P Maggioni, Fulvio Pomero, Ilaria Lobascio, Daniela P Pomata, Maria P Ruggeri, Beniamino Zalunardo, Anna Novelli, Giancarlo Agnelli, Lucio Gonzini, Michele M Gulizia
Journal: Blood (2022)
Safety and Pharmacokinetics of Subcutaneous Blinatumomab (SC blinatumomab) for the Treatment of Adults with Relapsed or Refractory B Cell Precursor Acute Lymphoblastic Leukemia (R/R B-ALL); Results from a Phase 1b Study
Authors: Pilar Martínez Sánchez, Gerhard Zugmaier, Paul Gordon, Elias Jabbour, José J. Rifón Roca, Stefan Schwartz, Erika Borlenghi, Francoise Huguet, Jesús María Hernández-Rivas, Federico Lussana, Céline Berthon, Priti Kadu, Hansen Wong, Ana Markovic, Yuliya Katlinskaya, Alessandro Rambaldi
Journal: Blood (2022)
Low Incidence of Fungal Infections after Chimeric Antigen Receptor T-Cell Therapy for Non-Hodgkin Lymphoma in an Endemic Region for Coccidioidomycosis
Authors: Charles Gaulin, Matthew Ulrickson, Muhammad Husnain, Madiha Iqbal, Paschalis Vergidis, Allison C. Rosenthal, Hemant S. Murthy, Carolyn Mead-Harvey, Yucai Wang, Januario E. Castro, Jeanne M. Palmer, Jose F. Leis, Patrick B. Johnston, Janis E. Blair, Mohamed A. Kharfan-Dabaja, Yi Lin, Javier Munoz
Journal: Blood (2022)
Novel Evidence That Pineal Gland Hormone Melatonin Inhibits Migration of Hematopoietic Stem/Progenitor Cells (HSPCs) By Inhibiting Nlrp3 Inflammasome and Upregulating Heme Oxygenase-1 (HO-1) - Implications to Understand Better Diurnal Trafficking of HSPCs and Anti-Inflammatory Effects of Melatonin
Authors: Ahmed Abdelbaset-Ismail, Arjun Thapa, Janina Ratajczak, Magda Kucia, Mariusz Z Ratajczak
Journal: Blood (2022)
Low-Dose Radiation Therapy with Nivolumab in Patients with Relapsed/Refractory Hodgkin Lymphoma: Results of the Phase II Radvax Trial
Authors: Michael J. LaRiviere, Tina Vaziri, Michael Farwell, Amit Maity, Ima Paydar, Stephen J. Schuster, Sunita Dwivedy Nasta, Elise A. Chong, Daniel J. Landsburg, John P. Plastaras, Jakub Svoboda
Journal: Blood (2022)
BRD9 Is Essential for Ribosome Biogenesis and the Survival of Multiple Myeloma Cells
Authors: Keiji Kurata, Mehmet K. Samur, Priscilla Liow, Kenneth Wen, Leona Yamamoto, Jiye Liu, Eugenio Morelli, Annamaria Gulla, Yu-Tzu Tai, Jun Qi, Teru Hideshima, Kenneth C. Anderson
Journal: Blood (2022)
External Validation Shows That Baseline PET Radiomics Outperform the IPI Risk Score for Prediction of Outcome in DLBCL
Authors: Jakoba J Eertink, Gerben JC Zwezerijnen, Martijn W Heymans, Simone Pieplenbosch, Sanne E Wiegers, Ulrich Dührsen, Andreas Hüttmann, Lars Kurch, Christine Hanoun, Pieternella Lugtenburg, Sally F Barrington, George Mikhaeel, Luca Ceriani, Emanuele Zucca, Sandor Czibor, Tamás Györke, Martine E.D. Chamuleau, Otto S Hoekstra, Henrica C.W de Vet, Ronald Boellaard, Josée M. Zijlstra
Journal: Blood (2022)
The Multi-Kinases Inhibitor ARQ531 Enhanches Anti-MM Activity of Imids By Dual Deregulation of MAP- and Cyclin-Dependent Kinases Activities
Authors: Debora Soncini, Pamela Becherini, Elisa Gelli, Claudia Martinuzzi, Fabio Guolo, Antonino Neri, Antonia Cagnetta, Roberto Massimo Lemoli, Michele Cea
Journal: Blood (2022)
Post-Allograft Romidepsin Maintenance Mitigates Relapse Risk and Stimulates the Graft-Versus-Malignancy Effect through Enhanced NK-Cell Cytotoxicity in Patients with Aggressive T-Cell Malignancies in a Phase I/II Trial
Authors: Chitra Hosing, Eric McLaughlin, Zachary Braunstein, Benigno C Valdez, Lai Wei, Uday R Popat, Borje S Andersson, Sumithira Vasu, Karilyn T. Larkin, Samantha Jaglowski, Sam Penza, Ayman Saad, Hannah Choe, Sarah A Wall, Alex Cash, Robin Nakkula, Richard E Champlin, Marcos J.G. de Lima, Dean Anthony Lee, Jonathan E Brammer
Journal: Blood (2022)
Autologous Stem Cell Transplant in 2nd Line DLBCL in 2022, Still the Standard of Care ? a Monocentric Experience
Authors: Aude Collignon, Benjamin Bouchacourt, Patrick Sfumato, Gabriel Brisou, Jean Marc Schiano de Collela, Luca Inchiappa, Boris Calmels, Claude Lemarié, Tibaulth Reichert, Samia Harbi, Raynier Devillier, Anne Calleja, Thomas Pagliardini, Guillaume Morel, Angela Granata, Norbert Vey, Reda Bouabdallah, Didier Blaise, Christian Chabannon, Robin Noel, Catalina Montes De Oca
Journal: Blood (2022)
Prospective and Retrospective Observational Study in Adult and Pediatric Patients with <i>GATA2</i> Variants (GATA2 Deficiency)
Authors: Samuele Roncareggi, Katia Girardi, Francesca Fioredda, Francesca Conti, Erika Borlenghi, Concetta Micalizzi, Gaia Mancuso, Fabiola Guerra, Emilia Cirillo, Antonio Marzollo, Piero Farruggia, Daniela Onofrillo, Riccardo Masetti, Raffaele Badolato, Luca Arcuri, Tiziana Angela Coliva, Francesca Vendemini, Claudio Pignata, Sonia Bonanomi, Andrea Biondi, Francesco Saettini
Journal: Blood (2022)
Daratumumab (Dara), Cyclophosphamide, Thalidomide and Dexamethasone for Transplant Eligible Newly Diagnosed Multiple Myeloma (TE NDMM) Patients: Response Rate Impacts on PFS
Authors: Edvan De Queiroz Crusoe, Joanna Leal, Juliana Andrade Santos, Herbert Henrique de Melo Santos, Allan de souza Santos, Larissa Ferreira Lucas, Alessandro de M. Almeida, Marcos Chaves, Daniela Dourado Dutra, Vania T.M. Hungria, Marco Aurelio Salvino, Maria da Gloria B. Arruda
Journal: Blood (2022)
Real-World Outcomes for Patients with Relapsed or Refractory (R/R) Aggressive B-Cell Non-Hodgkin's Lymphoma (aBNHL) Treated with Commercial Tisagenlecleucel: Subgroup Analyses from the Center for International Blood and Marrow Transplant Research (CIBMTR) Registry
Authors: Daniel J. Landsburg, Matthew Frigault, Michael Heim, Stephen Ronan Foley, Brian T. Hill, Christine M. Ho, Caron A. Jacobson, Samantha Jaglowski, Frederick L. Locke, Ron Ram, Peter A. Riedell, Gunjan L. Shah, Leslie L. Popplewell, Ranjan Tiwari, Stephen Lim, Marta Majdan, Aisha Masood, Marcelo C Pasquini, Cameron J. Turtle
Journal: Blood (2022)
Targeting Leukemic Stem Cells in Acute Myeloid Leukemia Using a CpG-Linked Anti-Mir-126 Oligonucleotide
Authors: Lucy Y Ghoda, Ebtesam Nafie, Elizabeth Bloom-Saldana, Patrick T. Fueger, Timothy Synold, James Simpson, Piotr Swiderski, Kokilah Muthaiyah, Bin Zhang, Marcin Kortylewski, Steven Vonderfecht, Le Xuan Truong Nguyen, Jianying Zhang, Joycelynne Palmer, Guido Marcucci
Journal: Blood (2022)
Impact of Qualified Dedicated APL Leukemia Specialist and Simplified Treatment Algorithm on Early Deaths in APL, a Monocenter Experience
Authors: Michal Jakub Kubiak, Anand P. Jillella, Danielle Bradshaw, Natasha M. Savage, Locke J. Bryan, Ravindra Kolhe, Vamsi K. Kota
Journal: Blood (2022)
Survival Outcomes for Patients in the QUAZAR AML-001 Trial Who Received Subsequent Therapy for Acute Myeloid Leukemia (AML) after Discontinuing Oral Azacitidine or Placebo
Authors: Farhad Ravandi, Pau Montesinos, Michael Pfeilstöcker, Cristina Papayannidis, Hervé Dombret, Yinzhi Lai, Erica Petrlik, Thomas Prebet, Hartmut Döhner
Journal: Blood (2022)
Population Pharmacokinetic Model Identifies an Optimal Fludarabine Exposure for Improved Outcomes after CD19-Directed CAR T Cell Therapy for Aggressive B-NHL: Analysis from the Cell Therapy Consortium
Authors: Michael Scordo, Jessica R. Flynn, Sean M. Devlin, Mithat Gonen, Allison Parascondola, Ana Alarcon Tomas, Roni Shouval, Jamie Brower, David L. Porter, Stephen J. Schuster, Veronika Bachanova, Joseph E. Maakaron, Richard T. Maziarz, Loretta J. Nastoupil, Joseph P. McGuirk, Olalekan O. Oluwole, Andrew Ip, Lori A. Leslie, Michael R. Bishop, Peter A. Riedell, Miguel-Angel Perales
Journal: Blood (2022)
Prospective Assessment of Motor Neurotoxicity and Sarcopenia in CD30+ Lymphoma Patients Treated with Brentuximab Vedotin. Single Center Multidisciplinary Unit Experience
Authors: Domingo Domenech Eva, Marta Bellver, German Ferrer, Eva Gonzalez Barca, Itziar Carro, Ana C Oliveira, Patricia Lopez, Gabriela Sanz-Linares, Carmen Aguilera, Montserrat Alemany, Inmaculada Peiro, Anna Sureda, Roser Velasco
Journal: Blood (2022)
A Retrospective Comparison of the Side Effect Prevalence and Severity of Multiple Myeloma Triplet Vs Quadruplet Induction Therapy
Authors: Nathan W. Sweeney, Emily W. Ballard, Eduardo Franco Hernandez, Andrea Isabel Robles Espinoza, Andrea Jimena Cuevas Vicencio, Patricia Alejandra Flores Pérez, Thomas H. Molina, Jennifer M. Ahlstrom, Jay R. Hydren
Journal: Blood (2022)
Increased Hemoglobin Affinity for Oxygen with GBT021601 Reduces Pulmonary Hypertension and Lung Vascular Inflammation in a Murine Model of Sickle Cell Disease
Authors: Kobina Dufu, Donna Oksenberg, Brian E Cathers, Carlos J Munoz, Cynthia R Muller, Pedro Pedro Cabrales
Journal: Blood (2022)
Haploidentical Donor Transplantation with Posttransplantation Cyclophosphamide in Myelodysplastic/Myeloproliferative Neoplasms: A Multi-Institutional Collaboration of 14 Centers
Authors: Tania Jain, Hua-Ling Tsai, Hany Elmariah, Pankit Vachhani, Theodoros Karantanos, Sarah A Wall, Lukasz P. Gondek, Asad Bashey, Alla Keyzner, Michael R. Grunwald, Sameem Abedin, Kalyan VG Nadiminti, Madiha Iqbal, Aaron T. Gerds, Auro Viswabandya, Shannon R McCurdy, MHD Monzr M. Al Malki, Ravi Varadhan, Haris Ali, Vikas Gupta, Richard J. Jones, Salman Otoukesh
Journal: Blood (2022)
The Outcome of Cytotoxic-T-Lymphocytes and Brentuximab on Post Transplant Lymphoproliferative Disorder: A Systematic Review and Meta-Analysis
Authors: Razwana Khanam, Zinath Roksana, Aleena Naeem, Rameesha Mehreen, Mohammad Ebad Ur Rehman, Zunairah Shah, Kiran Kuriakose, Saman Bahram, Faiz Anwer
Journal: Blood (2022)
Prognostic Factors in Children with Acute Myeloid Leukemia Receiving the First Hematopoietic Stem Cell Transplantation in Second Remission
Authors: Hisashi Ishida, Shin-ichi Tsujimoto, Daisuke Hasegawa, Hirotoshi Sakaguchi, Shohei Yamamoto, Masakatsu Yanagimachi, Katsuyoshi Koh, Akihiro Watanabe, Asahito Hama, Yuko Cho, Kenichiro Watanabe, Maiko Noguchi, Masanobu Takeuchi, Junko Takita, Kana Washio, Yoshiko Hashii, Ken Tabuchi, Moeko Hino, Yoshiko Atsuta, Yasuhiro Okamoto
Journal: Blood (2022)
A Single Next Generation Sequencing Assay for Detection of Driver Mutations, Translocations and Copy Number Alterations in Patients with Multiple Myeloma
Authors: Cecilia Bonolo De Campos, James B Smadbeck, Mariano Arribas, Neeraj Sharma, Gregory J Ahmann, Shaji K Kumar, A. Keith Stewart, Rafael Fonseca, P. Leif Bergsagel, Yan Asmann, Linda B. Baughn, Esteban Braggio
Journal: Blood (2022)
Differential Erythrocyte Phosphatidylserine Exposure Is Associated with Variations in Clinical and Haemostatic Parameters: A Study Involving E-β and β Thalassemia Compared to Normal Population
Authors: Rajib De, Rabindra Kumar Jena, Rishu Vidhatri, Tuphan Kanti Dolai, Shuvra Neel Baul
Journal: Blood (2022)
Genome-Wide CRISPR-Cas9 Screen Identifies KDM6A As a Modulator of Daratumumab Sensitivity in Multiple Myeloma
Authors: Jiye Liu, Lijie Xing, Teru Hideshima, Keiji Kurata, Mehmet K. Samur, Eugenio Morelli, Kenneth Wen, Nikhil C Munshi, Kenneth C. Anderson
Journal: Blood (2022)
Specific Nucleotide Substitutions and Stressors Erode Highly Conserved Genomic Regions in Acute Myelogenous Leukemia
Authors: Nikhil Patel, Gustavo Rivero, Martha P. Mims, Purnima Sravanti Teegavarapu, Gianfranco Bittar, Diana De Oliviera
Journal: Blood (2022)
Improved Survival of Patients with Primary Plasma Cell Leukemia with VRD or Daratumumab-Based Quadruplets: A Multicenter Study By the Greek Myeloma Study Group
Authors: Eirini Katodritou, Efstathios Kastritis, Dimitra Dalampira, Sosana Delimpasi, Emmanouil Spanoudakis, Vassiliki Labropoulou, Ioannis Ntanasis-Stathopoulos, Annita Ioanna Gkioka, Nikolaos Giannakoulas, Nikolaos Kanellias, Aggeliki Sevastoudi, Evridiki Michali, Maria Papathanasiou, Maria Kotsopoulou, Anastasia Sioni, Theodora Triantafyllou, Mavra Papadatou, Ioannis V Kostopoulos, Evgenia Verrou, Meletios-Athanasios Dimopoulos, Evangelos Terpos
Journal: Blood (2022)
Sars-Cov-2 Vaccination Response Monitoring in Lymphoma and Multiple Myeloma Patients Following Standard Versus High-Dose Chemotherapy and Autologous Stem Cell Transplantation
Authors: Uros Markovic, Giulio Antonio Milone, Daniela Carco, Valeria Iachelli, Nunziatina Laura Parrinello, Paola Scire, Gabriella Amato, Federica Galbo, Giuseppe Milone, Emanuele Martorana, Gaetano Moschetti
Journal: Blood (2022)
Recurrent Copy Number Alterations Contribute to a Unique Genetic Landscape in Relapsed-Refractory DLBCL
Authors: Christopher K Rushton, Ryan N Rys, Elizabeth Chavez, Laura K Hilton, Miguel Alcaide, Kostiantyn Dreval, Matthew Cheung, Manuela Cruz, Krysta M. Coyle, Barbara Meissner, Susana Ben-Neriah, Neil R. Michaud, Scott Daigle, Jordan Davidson, Jasper Wong, Annette E. Hay, Michael D. Jain, Lois E. Shepherd, Marco A. Marra, John Kuruvilla, Michael Crump, Koren Kathleen Mann, Sarit Assouline, Christian Steidl, David W. Scott, Nathalie A. Johnson, Ryan D. Morin
Journal: Blood (2022)
Genetic Variation and Survival Analysis of Childhood AML By C-Huanan AML 2015 Protocol in China:Multicenter Clinical Study in 546 Cases
Authors: Xiaoqin Feng, Chunfu Li, Jian Li, Mincui Zheng, Sixi Liu, Lihua Yang, Hua Jiang, Honggui Xu, Hong Wen, Xiangling He
Journal: Blood (2022)
Sub-Cutaneous Administration of Rituximab Triggers a Pro-Phagocytic Phenotype of Monocytic Compartment in Low-Tumor Burden Follicular Lymphoma Patients Included in the Flirt Clinical Trial, a Lysa Study
Authors: Mikael Roussel, Cedric Menard, Delphine Rossille, Julien Saint-Vanne, Joelle Dulong, Emmanuel Bachy, Herve Tilly, Delphine Pranger, Franck Morschhauser, Luc Xerri, Guillaume Cartron, Karin Tarte
Journal: Blood (2022)
Complement Drives Acute Chest Syndrome in a Model of Sickle Cell Disease
Authors: Satheesh Chonat, Jayre A Jones, Seema R Patel, Patricia E Zerra, Lauren A Jeffers, Ryan Philip Jajosky, Connie M. Arthur, Michael Koval, Clinton H. Joiner, David R. Archer, Sean R. Stowell
Journal: Blood (2022)
Final Results from UKALL60+ (NCT01616238), a UK National Cancer Research Institute Trial for Older People with <i>De Novo</i> Acute Lymphoblastic Leukaemia
Authors: Bela Patel Wrench, Amy A. Kirkwood, Krisztina Zuborne Alapi, Laura Clifton-Hadley, SooWah Lee, David I. Marks, Anthony V. Moorman, Nicholas J. Morley, Pip Patrick, Zaynab Rana, Clare J. Rowntree, John A. Snowden, Adele K. Fielding
Journal: Blood (2022)
Proteomic Analysis Identifies Epigenetic Modifiers and Potential Negative Regulators of Leukemogenesis KMD6A and SETDB1 to be Induced Post <i>In Vivo</i> Decitabine Exposure in Pediatric AML
Authors: Jatinder K. Lamba, Xueyuan Cao, Huiyun Wu, Hiroto Inaba, Raul C. Ribeiro, Junmin Peng, Tanja A. Gruber, Jeffrey E. Rubnitz, Stanley B. Pounds
Journal: Blood (2022)
GBT021601 Prevents Microvascular Dysfunction and Improves Hypoxia-Reoxygenation-Induced Vaso-Occlusion in a Murine Model of Sickle Cell Disease
Authors: Kobina Dufu, Donna Oksenberg, Brian E Cathers, Carlos J Munoz, Cynthia R Muller, Pedro Pedro Cabrales
Journal: Blood (2022)
Ultrasensitive Circulating Tumor DNA (ctDNA) Dynamics after Autologous CD30.CAR-T Cell Therapy for Relapsed or Refractory (r/r) Classical Hodgkin Lymphoma (CHARIOT Trial)
Authors: David M. Kurtz, Sairah Ahmed, Cheuk Ka Tong, Matthew Mei, Cliff Ding, Ian W. Flinn, Peter A. Riedell, Gregory J. Hogan, Andre Schultz, Jacob J. Chabon, Helen E. Heslop, Aung Myo, Ash A. Alizadeh, Ivan D. Horak
Journal: Blood (2022)
Novel Sheep Model of Sickle Cell Disease Reproduces Human Clinical and Laboratory Parameters
Authors: Caroline E. Kuczynski, Iuri V. Perisse, Misha Regouski, Elmira Alipour, Cecily LaPradd, Ying Liu, Michael W. Beaty, Daniel B. Kim-Shapiro, Anthony Atala, Irina Polejaeva, Christopher D. Porada, M. Graca Almeida-Porada
Journal: Blood (2022)
Zanubrutinib Plus Rituximab for the Treatment of Elderly Unfit Patients with Previously Untreated Diffuse Large-B Cell Lymphoma
Authors: Jiefei Bai, Jiangtao Li, Ru Feng, Long Qian, Jingjing Yin, Shuai Zhang, Ting Wang, Yazi Yang, Chunli Zhang, Jian Li, Hui Liu
Journal: Blood (2022)
Lisocabtagene Maraleucel (liso-cel) Versus Standard of Care (SOC) with Salvage Chemotherapy Followed By Autologous Stem Cell Transplantation (ASCT) As Second-Line (2L) Treatment in Patients with Relapsed or Refractory Large B-Cell Lymphoma (LBCL): Primary Analysis of the Randomized, Phase 3 Transform Study
Authors: Jeremy S. Abramson, Scott R. Solomon, Jon E. Arnason, Patrick B. Johnston, Bertram Glass, Veronika Bachanova, Sami Ibrahimi, Stephan Mielke, Pim Mutsaers, Francisco Hernandez-Ilizaliturri, Koji Izutsu, Franck Morschhauser, Matthew A. Lunning, Alessandro Crotta, Sandrine Montheard, Alessandro Previtali, Manali Kamdar
Journal: Blood (2022)
Neutrophil membrane-camouflaged nanoparticles alleviate inflammation and promote angiogenesis in ischemic myocardial injury
Authors: Dongjian Han, Fuhang Wang, Zhentao Qiao, Bo Wang, Yi Zhang, Qingjiao Jiang, Miaomiao Liu, Yuansong Zhuang, Quanxu An, Yan Bai, Jiahong Shangguan, Jinying Zhang, Gaofeng Liang, Deliang Shen
Journal: Bioactive Materials (2022)

Acute myocardial infarction (AMI) induces a sterile inflammatory response, leading to cardiomyocyte damage and adverse cardiac remodeling. Interleukin-5 (IL-5) plays an essential role in developing eosinophils (EOS), which are beneficial for the resolution of inflammation. Furthermore, the proangiogenic properties of IL-5 also contribute to tissue healing following injury. Therefore, targeted delivery of IL-5 is an innovative therapeutic approach for treating AMI. It has been shown that conventional IL-5 delivery can result in undesirable adverse effects and potential drug overdose. In this study, we successfully synthesized a biomimetic IL-5 nanoparticle by camouflaging the IL-5 nanoparticle in a neutrophilic membrane. The administration of neutrophil membrane-camouflaged nanoparticles (NM-NPIL-5) in the in vivo model showed that these nanoparticles promoted EOS accumulation and angiogenesis in the infarcted myocardium, thereby limiting adverse cardiac remodeling after AMI. Our results also demonstrated that the NM-NPIL-5 could serve as neutrophil "decoys" to adsorb and neutralize the elevated neutrophil-related cytokines in the injured heart by inheriting multiple receptors from their "parent" neutrophils. Finally, the targeted delivery of NM-NPIL-5 protected the cardiomyocytes from excessive inflammatory-induced apoptosis and maintained cardiac function. Our findings provided a promising cardiac detoxification agent for acute cardiac injury.
Quantitative MRI Identifies Heterogeneous Bone Marrow Treatment Responses in a Mouse Model of Myelofibrosis
Authors: Tanner H Robison, Manisha Solipuram, Winston Y Lee, Kathryn Luker, Kristen M. Pettit, Moshe Talpaz, Dariya Malyarenko, Thomas Chenevert, Brian Ross, Gary Luker
Journal: Blood (2022)
Real-World Results of Autologous Stem Cell Transplantation in Newly Diagnosed Patients with Multiple Myeloma: A Multi-Institutional Report from the Canadian Myeloma Research Group (CMRG) Database
Authors: Julie Cote, Richard Leblanc, Michael P. Chu, Arleigh McCurdy, Esther Masih-Khan, Moustafa Kardjadj, Victor H Jimenez-Zepeda, Kevin Song, Martha L Louzada, Hira S Mian, Darrell White, Michael Sebag, Anthony Reiman, Julie Stakiw, Rami Kotb, Debra Bergstrom, Muhammad Aslam, Rayan Kaedbey, Christopher P. Venner, Engin Gul, Donna E. Reece
Journal: Blood (2022)
Effective and Safe Immune Checkpoint Blockade Induces Complete Responses in Murine PTCL Model of ALCL
Authors: Linda Gräßel, Teresa Poggio, Geoffroy Andrieux, Irene Gonzalez-Menendez, Stefanie Kreutmair, Cornelius Miething, Federico Bonofiglio, Ivonne Aidee Montes Mojarro, Marie Follo, Dietmar Pfeifer, Falko Fend, Leticia Quintanilla-Martinez, Robert Zeiser, Suzanne Turner, Melanie Börries, Justus Duyster, Anna Lena Illert
Journal: Blood (2022)
Treatment Patterns and Characteristics Among Patients with Myelodysplastic Syndromes Initiating Oral Decitabine and Cedazuridine or Intravenous/Subcutaneous Hypomethylating Agents in a Real-World Setting
Authors: Amer M. Zeidan, Victoria Divino, Mitch DeKoven, Elizabeth Wang, Justin Chen, Tehseen Salimi, Robert S. Epstein
Journal: Blood (2022)
Phase II Study of Pembrolizumab and Fractionated External Beam Radiotherapy in Patients with Relapsed and Refractory Large B-Cell Lymphoma
Authors: Chelsea C. Pinnix, Bouthaina S. Dabaja, Jillian R. Gunther, Penny Fang, Susan Wu, Sairah Ahmed, Raphael E Steiner, Ranjit Nair, Paolo Strati, Jason Westin, Luis Fayad, Swami P. Iyer, Maria Alma Rodriguez, Hun Ju Lee, Felipe Samaniego, Dai Chihara, Preetesh Jain, Lei Feng, Christopher R. Flowers, Sattva S. Neelapu, Loretta J. Nastoupil
Journal: Blood (2022)
A Closer Look at Changes in Hemoglobin Levels in Patients with Non-Transfusion Dependent β-Thalassemia Treated with Luspatercept: Post Hoc Analysis of the Phase 2 BEYOND Trial
Authors: Khaled M. Musallam, Ali T. Taher, John B. Porter, Antonis Kattamis, Mrudula B. Glassberg, Luciana Bueno, Jeevan K. Shetty, Frederik Lersch, Barbara Rosettani, Maria Domenica Domenica Cappellini
Journal: Blood (2022)
The Pre-Existing T Cell Landscape Is Associated with Response to High Dose Melphalan and Autologous Stem Cell Transplant in Multiple Myeloma
Authors: Mohammad Issam Abu Zaid, Parvathi Sudha, Travis S Johnson, Vivek S. Chopra, Cedric E. Dos Santos, Michael Nixon, Attaya Suvannasankha, Sherif S Farag, Kelvin P. Lee, Rafat Abonour, Brian A. Walker
Journal: Blood (2022)
Circulating RAS/RAF and DNA-Repair Gene Mutations Associates with High-Risk/Treatment Resistance in Primary Refractory Multiple Myeloma
Authors: Sridurga Mithraprabhu, John Reynolds, Rose Turner, Hang Quach, Noemi Horvath, Ian H Kerridge, Flora Yuen, Tiffany Khong, Brian G.M. Durie, Andrew Spencer
Journal: Blood (2022)