tbuckley/cabot-search huggingface dataset:
Diagnosis of Schistosomiasis
Authors: Bernard Zilberg
Journal: JAMA (1985)

<h3>To the Editor.—</h3> In the article entitled "Acute Schistosomiasis Among Americans Rafting the Omo River, Ethiopia" Istre et al<sup>1</sup>describe very clearly the features and natural course of "Katayama syndrome." They state that this stage occurs with<i>Schistosoma mansoni and Schistosoma japonicum</i>infections. This syndrome has also been described in<i>Schistosoma haematobium</i>infections.<sup>2-4</sup> This stage of the disease is usually considered to run a benign course, but more serious and varied manifestations may be present. Cardiac and cerebral complications have been described,<sup>2,3</sup>as well as features of the Henoch-Schönlein syndrome.<sup>3</sup>As the risk of schistosomiasis may now have to be seriously considered for visitors and American residents who have traveled abroad, it is well to note that examination of rectal mucosal biopsy specimens often leads to earlier diagnosis than stool and urine studies. This method of diagnosis is also very reliable in<i>S haematobium</i>, and, in
THE SERUM PROPHYLAXIS OF MEASLES
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Alcohol on Hypoxia
Authors: Joe L. Nettles
Journal: JAMA (1965)

In an effort to determine the effects of alcohol upon the time of useful consciousness of a subject when he is suddenly subjected to hypoxic conditions, ten normal subjects were taken to an atmosphere simulating 25,000 feet (288 mm Hg) in an altitude chamber. After their oxygen masks were removed, they performed various tasks requiring mental and physical coordination until definite hypoxic symptoms were manifested. Later, these same subjects were submitted to identical conditions after the administration of 0.5 cc of 100-proof whiskey per pound of body weight. Blood alcohol levels were determined upon the completion of experiment. A comparison of results demonstrated a 38% reduction in the time of useful consciousness under such hypoxic conditions. In the age of pressurized aircraft subject to rapid decompression, this 38% reduction may easily spell the difference between life and death.
Strahlenbehandlung bei Kinderkrankheiten.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cardiac Output of Man in Health and Disease.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psychosomatic Medicine: Its Principles and Applications.
Journal: Annals of Internal Medicine (1951)

subject.The book is of value to the urologist as well as to the general practitioner and would well repay considerable study.While non-gonorrheal urethritis is a rare disease and is frequently mistakenly diagnosed and difficult to treat, it is a condition that responds readily to correct therapy.Harkness' work will make a valuable and satisfying addition to the library of anyone who is occasionally called on to diagnose urethritis of any origin.
Highlights of This Issue
Journal: Clinical Cancer Research (2015)

Dysregulation of Notch signaling promotes cancer growth through several mechanisms, including the maintenance of tumorigenic cells and functional tumor vasculature. Yen and colleagues report the development and characterization of a dual antagonist antibody that inhibits both Notch2 and Notch3 (OMP-59R5, tarextumab). OMP-59R5 inhibited tumor growth, decreased cancer stem cell frequency, and modulated the function of tumor vasculature in a variety of patient-derived xenografts. In pancreatic cancer, efficacy was associated with higher levels of Notch3 expression, providing a potential biomarker for patient selection. Tarextumab is currently advancing in Phase 2 clinical testing for treatment of pancreatic and small cell lung cancers.The microRNA miR-27a directly regulates dihydropyrimidine dehydrogenase (DPD), the key enzyme in fluoropyrimidine catabolism. To investigate if miR-27a may influence toxicity risk in fluoropyrimidine-based chemotherapy, Amstutz and colleagues assessed the association of genetic polymorphisms in MIR27A with early-onset fluoropyrimidine toxicity. The common MIR27A variant rs895819—previously shown to affect miR-27a levels—was strongly associated with severe early-onset toxicity in patients also carrying risk variants in the DPD gene. This suggests that miR-27a and polymorphisms affecting its expression may serve as novel, complementary markers for further patient risk stratification in DPD risk variant carriers to improve the specificity of genetic testing.Chemotherapy targets rapidly proliferating cells, thus sparing slowly-dividing hypoxic cells that can contribute to repopulation in between courses of treatment. Hypoxia-activated prodrugs (TH-302) selectively kill hypoxic cells and may inhibit tumor repopulation and, in combination with chemotherapy, may increase tumor control. Saggar and colleagues investigated changes in reoxygenation within the tumor microenvironment by administrating two sequential markers of hypoxia following treatment with doxorubicin/docetaxel +/− TH-302. It was found that (i) chemotherapy induces reoxygenation of previously hypoxic cells and leads to tumour repopulation, and (ii) TH-302 reduces this effect. This supports the potential of TH-302 to increase therapeutic effects of chemotherapy.EGFR blockade with the antibody cetuximab is effective in patients with wt-RAS metastatic colorectal cancer (CRC). Unfortunately, responses are transient and patients invariably develop acquired resistance. Arena and colleagues analyzed the genetic profile of clinical samples and preclinical models of acquired resistance to cetuximab. They identified five novel point mutations in the EGFR ectodomain, which confer resistance to cetuximab in CRC patients and cells. Functional analysis of cellular models revealed that a subset of the EGFR mutations retains sensitivity to panitumumab. This knowledge is being incorporated in clinical trials aimed at overcoming acquired resistance to cetuximab in colorectal cancer patients.
Upper-Body Fat Distribution and Endometrial Cancer Risk
Authors: David V. Schapira
Journal: JAMA (1991)

<h3>Study Objective.</h3> —To determine if body fat distribution affected endometrial cancer risk. <h3>Design.</h3> —Case-control study. <h3>Setting.</h3> —This study was carried out at the H. Lee Moffitt Cancer Center at the University of South Florida, Tampa, where all patients in the case group received their diagnoses and histological confirmations. <h3>Patients.</h3> —Forty consecutive women newly diagnosed with endometrial cancer and 40 controls matched for age and Quetelet index. <h3>Main Outcome Measures.</h3> —Anthropometric measurements were taken for the abdomen, thigh, suprailiac, subscapular, biceps, and triceps skin fold thicknesses; waist and hip circumferences, weight, and height. Relative risks for endometrial cancer were calculated according to these anthropometric measurements. <h3>Results.</h3> —Case patients with endometrial cancer had significantly greater waist-to-hip circumference ratios (<i>P</i>&lt;.001), abdomen-to-thigh skin fold ratios (<i>P</i>&lt;.01), and suprailiac-to-thigh skin fold ratios (<i>P</i>=.02) compared with control subjects matched for age and Quetelet index. The relative risk for endometrial cancer increased with an increasing waist-to-hip circumference ratio (≤1.14 = 1.0; &gt;1.14 = 15.0), with an increasing abdomen-to-thigh skin fold ratio (≤0.82= 1.0; &gt;0.82 = 5.0), and with an increasing suprailiac to-thigh skin fold thickness ratio (≤0.67 = 1.0; &gt;0.67 = 3.50). <h3>Conclusion.</h3> — Upper-body fat localization is a significant risk factor for endometrial cancer in women matched for age and Quetelet index. (<i>JAMA</i>. 1991;266:1808-1811)
Migrating Docs: Studying Physician Practice Location
Authors: Thomas R. Konrad
Journal: JAMA (1995)

<h3>To the Editor.</h3> —By highlighting the issue of physician migration and linking it to graduate medical education (GME), Dr Seifer and colleagues<sup>1</sup>have contributed to the recognition that we now have a national market for medical education and physician services. They suggest that states with medical training institutions having national reputations do not necessarily distribute their products nationally, while states that try to deploy local trainees to their own hinterlands often lose them to other states. However, their finding that "[o]verall, 51% of physicians are practicing in the state in which they obtained their graduate medical education" may understate the true nature, extent, and meaning of geographic mobility over the life span of physicians and may overlook some of the downstream policy implications. We have recently examined physician migration into and out of rural counties in the 48 contiguous states from 1987 to 1990, using annual address changes from
Highlights of This Issue
Journal: Clinical Cancer Research (2014)

NSCLC with mutations in the EGF receptor often develop resistance to first-line targeted therapy.The mucin 1 C-terminal (MUC1-C) oncoprotein associates with EGFR and is aberrantly overexpressed in NSCLC.Here in NSCLC cells harboring EGFR mutations, unanticipated findings demonstrate that targeting MUC1-C with stable silencing, expression of a DN mutant, or treatment the MUC1 inhibitor (GO-203) results in downregulation of EGFR signaling and inhibition of growth, clonogenic survival, and tumorigenicity.Of therapeutic relevance, GO-203 and the irreversible EGFR inhibitor afatinib were found to be more effective in combination in inhibiting survival of EGFR mutant NSCLC cells than either agent alone.These findings highlight the novelty of MUC1-C in driving activation of mutant EGFR signaling in NSCLC cells.
Socioeconomic Status, Sunlight Exposure, and Risk of Malignant Melanoma: The Western Canada Melanoma Study&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: Richard P. Gallagher, J. Mark Elwood, William J. Threlfall, John J. Spinelli, Shirley Fincham, Gerry B. Hill
Journal: JNCI Journal of the National Cancer Institute (1987)

In a study of 261 male melanoma patients and age-and sex-matched controls, a strong positive univariate association between socioeconomic status, as determined by usual occupation, and risk of melanoma was detected. This association, however, was substantially explained by host constitutional factors and occupational, recreational, and vacation sunlight exposure. The study demonstrated an increased risk of melanoma in draftsmen and surveyors and a reduced risk of melanoma in construction workers and individuals employed in the finance, insurance, and real estate industry even after control for the effect of host factors and sunlight exposure.
The Common Diseases of the Skin. A Handbook for Students and Medical Practitioners.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Guilt of Streptococcus proved
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CLINICAL HISTORY OF THE CASE OF PRESIDENT JAMES ABRAM GARFIELD.
Authors: ROBERT REYBURN
Journal: JAMA (1894)

(<i>Continued from page 502</i>.) IV. August 8, 6a.m.He had five ounces of koumiss. At 8a.m.seven ounces of koumiss. At 8:40a.m.he took five ounces of claret. August 8, 8:30a.m.Temperature 98.4; pulse 94; respirations 18. August 8, 12 M. Temperature 100.2; pulse 104; respirations 20. August 8, 7p.m.Temperature 101.2; pulse 108; respirations 19. The President's wound was dressed at 8a.m.and it being evidently necessary to make a more free opening in the wound to facilitate the escape of pus, he was etherized this morning, and the operation performed. Dr. Reyburn administered the ether, and it acted very quickly and pleasantly. The incision was extended downwards and forwards, and a I counter-opening was made into the track of the bullet below the margin of the twelfth rib; this was done by Dr. Agnew. Two drainage tubes were then inserted. The President
Dermatitis herpetiformis.
Authors: N. Levine Prof. Dr., C. C. Levine
Journal: BMJ (1971)

The state of our understanding of the pathogenesis of DH relies on the integration of several key characteristics: (1) a high frequency of the HLA antigens HLA-B8, HLA-DR3, and HLA-DQw2, (2) an associated GSE, (3) the resolution of both the skin lesions and gut abnormalities in response to a gluten-free diet, and (4) the presence of granular deposits of IgA in normal and perilesional skin. The role of the HLA class II antigens expressed in patients with DH most likely relates to the afferent or initiating arm of the immune system. The association of the HLA-A1, -B8, -DR3, -DQw2 haplotype with Sjogren's syndrome, chronic hepatitis, Graves' disease, and other presumably immunologically mediated diseases, as well as the evidence that some normal HLA-B8, -DR3 individuals have an abnormal in vitro lymphocyte response to wheat protein and mitogens and have abnormal Fc-IgG receptor-mediated functions, suggests that this HLA haplotype or genes linked closely to it may confer a generalized state of immune susceptibility on its carrier, the exact phenotypic expression of which depends on other genetic or environmental determinants. It also is clear, from the association of DH with GSE and the ability to control the cutaneous manifestations of DH with a gluten-free diet, that the gut disease is a critical factor in the pathogenesis of DH. Several pathogenetic theories about the origin of the cutaneous IgA deposits in DH have been proposed, one of which states that the IgA is produced in the gut mucosa as a response to a dietary antigen or gut epithelial antigen and then cross-reacts with the skin of patients with DH. A second hypothesis is that the IgA produced in the gut binds to an antigen and is deposited in skin as an antigen-antibody complex. Finally, it could be that the gut mucosal abnormality simply allows an unknown antigen access to the central immune system where an IgA antibody is produced that binds to skin. The failure to detect circulating IgA anti-basement membrane zone antibodies in patients with DH suggests that either the structures to which the IgA binds are not present in normal skin without DH, that IgA cannot bind to these structures in vitro, or that the circulating IgA is too scant for detection with conventional methods. Finally, it must be considered that the IgA deposited in DH skin may bind as a result of non-antigen-antibody interactions that cannot be duplicated in vitro.(ABSTRACT TRUNCATED AT 400 WORDS)
The Principles and Practice of Bandaging.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pancreatic pseudocyst in the left hepatic lobe: A report of two cases
Authors: Kunjo Okuda, Shujiro Sugita, Etsuo Tsukada, Yoichi Sakuma, Keishi Ohkubo
Journal: Hepatology (1991)

The ultrasound and computed tomographic imaging features in a rare pancreatic pseudocyst of the liver are described in two patients. The pseudocysts occurred in the left lobe in both cases, one after a traumatic injury and the other after alcoholic pancreatitis. The possible topographical sequences with which pancreatic secretions entered the left hepatic lobe to form a cyst are discussed. (Hepatology 1991;13:359-363).
Serial Carcinoembryonic Antigen Assays
Authors: Jeffrey J. Sorokin
Journal: JAMA (1974)

A prospective study of 102 patients who had undergone potentially curative operations for colorectal cancer was undertaken to correlate serial carcinoembryonic antigen (CEA) levels with the clinical course. When included in this study, patients selected had no detectable metastatic or recurrent disease. Twelve patients developed sustained elevations in their CEA levels greater than 2.5 ng/ml. Six of these had progressively rising CEA titers, and all developed subsequently recurrent cancer; rising CEA levels were observed 0 to 29 months before cancer recurrence was clinically detected. The six with "stable" elevations and six with transient elevations developed no clinically detectable cancer. Eighty-four patients with CEA levels consistently under 2.5 ng/ml had no evidence of recurrent neoplasms. Two developed second primaries. Serial CEA assays postoperatively help detect recurrent colon cancer in asymptomatic patients. (<i>JAMA</i>228:49-53, 1974)