tbuckley/cabot-search huggingface dataset:
Letters
Authors: Jennifer R. Hartmark-Hill
Journal: Annals of Internal Medicine (2015)

Letters17 November 2015LettersJennifer R. Hartmark-Hill, MDJennifer R. Hartmark-Hill, MDFrom University of Arizona College of Medicine—Phoenix, Phoenix, Arizona.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5167 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Carolla's essay (1) on the importance of physician-written letters to patients' families touched my heart and inspired reflection. Narratives of clinicians taking the time to contemplate and show value for patients in the form of a letter are notable. One example is a letter written to the family of a woman with breast cancer that was picked up by CBS and other national syndicates after the woman's son posted it online. It went viral (2). The positive public reaction, in addition to the private reactions of families who receive similar letters, shows the effect that a few ...References1. Carolla RL. On being a doctor. Letters. Ann Intern Med. 2015;163:66. [PMID: 26148283] LinkGoogle Scholar2. CBS News. Letter from emergency room doctor goes viral. 16 February 2013. Accessed at www.cbsnews.com/news/letter-from-emergency-room-doctor-goes-viral on 9 July 2015. Google Scholar3. Epstein RM, Krasner MS. Physician resilience: what it means, why it matters, and how to promote it [Editorial]. Acad Med. 2013;88:301-3. [PMID: 23442430] CrossrefMedlineGoogle Scholar4. Bolton GE. Reflective Practice: Writing and Professional Development. London: Sage; 2014. Google Scholar Author, Article, and Disclosure InformationAuthors: Jennifer R. Hartmark-Hill, MDAffiliations: From University of Arizona College of Medicine—Phoenix, Phoenix, Arizona.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L15-0451. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLetters Robert L. Carolla Metrics 17 November 2015Volume 163, Issue 10Page: 806KeywordsBreast cancerDisclosureHealth careHeart ePublished: 17 November 2015 Issue Published: 17 November 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
PWE-076 Elastic scattering spectroscopy is highly accurate for the detection of high-grade dysplasia and DNA ploidy arising in Barrett's oesophagus using a red enhanced spectrometer
Authors: J M Dunn, Y Jiao, M Austwick, C A Mosse, D Oukrif, S Thorpe, M R Novelli, M B Banks, S G Bown, L B Lovat
Journal: Gut (2010)

<h3>Introduction</h3> Elastic scattering spectroscopy (ESS) is an emerging optical diagnostic technique which detects cellular abnormalities in vivo. In patients undergoing endoscopic surveillance for Barrett9s oesophagus (BE), we have demonstrated ESS is able to detect high-grade dysplasia (HGD) and DNA ploidy, both associated with significant increase in 5-year cancer risk (59% and 28%, respectively). The spectrometer used had a wavelength range of 350–800 nm, where there is significant haemoglobin absorption. We hypothesise that a red enhanced spectrometer, more sensitive in the range 450 nm–1000 nm, would detect more scattering data and may improve detection rates. The aim of this in vivo study was to assess the influence of the spectral range of the spectrometer on accuracy of diagnosis. <h3>Methods</h3> Spectral data for each spectrometer were collected at matched sites in vivo. A biopsy of the site was then taken from each site and histopathology reviewed. DNA ploidy was then assessed by image cytometric DNA analysis (ICDA) on these biopsies as previously described. A diagnostic algorithm of best fit was generated by principle component and linear discriminant analysis on the histology and DNA ploidy data. <h3>Results</h3> 49 patients were enrolled in the study, with 217 sites analysed. ESS using a red enhanced spectra was able to distinguish squamous and columnar tissue with comparable accuracy to a standard spectrometer (91% sensitivity and 91% specificity). When comparing HGD vs non-dysplastic tissue, there was also little difference between the two spectrometers. Sensitivity with the red enhanced spectrometer was 84%, with specificity of 83%, respectively. The standard spectrometer sensitivity was 86% and specificity of 83%. When combining aneuploidy+HGD vs normal columnar tissue, however, the red spectrometer was more accurate with sensitivity 90% and specificity 80%. The standard spectrometer sensitivity was 90% but specificity was 74%. <h3>Conclusion</h3> These data demonstrate ESS is highly accurate for the detection of BE and associated HGD and molecular abnormalities in vivo, whichever spectrometer is used. The red enhanced spectrometer is somewhat more accurate for the detection of DNA ploidy abnormalities than a standard spectrometer. We intend to test this spectrometer in a prospective equivalence study, comparing ESS with targeted detection of HGD and aneuploidy vs surveillance with quadrantic biopsy.
Making Amends: Ecological Restoration in the United States
Authors: John Tibbetts
Journal: Environmental Health Perspectives (2000)

Restoring an ecosystem to its preindustrial state can be very difficult or impossible. The great majority of restoration projects put a high priority on the biological requirements of endangered species, often drawing ecologists into volatile political controversies over the rights of humans versus those of wildlife. Meanwhile, resource managers struggle to gain enough information about historical ecosystems to reconstruct them successfully. There are often difficult judgment calls when scientists try to redesign a system that has been degraded over many generations, and it's often confusing to decide which period of history to restore an ecosystem to. In addition, modern industrialized society continues to place extensive demands upon already-stressed, degraded ecosystems. Restoration projects in the Florida Everglades, Pacific Northwest riverine systems, and forests in the Southeast illustrate the challenges associated with ecological restoration.
Immtav, a novel immunotherapy approach to eliminate hepatitis B virus
Authors: Ruth Martinez Hague, Dominic Hine, Joannah Fergusson, Zoë Wallace, Amanda Woon, Daniel Kay, Jose Donoso, Marcin Dembek, Mary Connolly, Richard Suckling, Sara Crespillo Torreno, Wilawan Bunjobpol, Andrew Knox, Sarah Leonard, Bethany Turner, Katrin Wiederhold, Mala Maini, Stephen Megit, Lucy Dorrell
Journal: Journal of Hepatology (2020)
Ecotoxicity in the Reconquista River, Province of Buenos Aires, Argentina: A Preliminary Study
Authors: Jorge Herkovits, Cristina Silvia Perez-Coll, Francisco Damian Herkovits
Journal: Environmental Health Perspectives (1996)

The Reconquista River in Argentina i considered a cri al' river basin due to environ- mental degradtioWith itvlly of L547 u. them ateinre tan3 mion inh.0 tants and 12,000 industries.Using early-life-stage~~~~~~~~~~~.ests wit .fm.. ru.. emryos.(thmost e of the nat )w dermined th water qualit at si sapling sons river, theoxicitywas er than the alloable level of wole dstnal effluent toxicity rcm- miended U.S. EPA.In a tiuaystrem, rry MoMa, te waer wa aout) times more ...P~~~~~~~~~~~~~~~~~..
Building medical bridges— cardiology from AMA to Zagreb
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Co-administration of PF-05221304 and PF-06865571 delivers robust whole liver fat reduction and mitigation of acetyl-coa carboxilase inhibitor induced hypertriglyceridemia in patients with NAFLD
Authors: Roberto Calle, Sudeepta Aggarwal, Jessica Mancuso, Arthur Bergman, Veena Somayaji, Trenton Ross, William Esler
Journal: Journal of Hepatology (2020)
Drug Duo Disappoints in Colorectal Cancer
Journal: Cancer Discovery (2018)

A phase III study determined that the combination of atezolizumab and cobimetinib wasn't more effective than standard therapy in patients with inoperable, locally advanced or metastatic colorectal cancer. The overall survival for patients treated with the combination was 8.9 months, versus 8.5 months for standard-of-care regorafenib. Further, only 2.7% of patients responded to the drug duo, versus 2.2% for regorafenib.
STRONGYLOIDES INTESTINALIS IN THE UNITED STATES.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Social Work Therapy and Psychiatric Psychotherapy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sudden and unexpected deaths in young adults. An epidemiological study
Authors: L. Kuller
Journal: JAMA (1966)

An epidemiological study of sudden and unexpected death was conducted in Baltimore city during 1964 and 1965. Of the 322 nontraumatic deaths reviewed, 101 (31.4%) were sudden and unexpected. Sudden, unexpected deaths were more common in Negroes and men. Alcoholism and fatty liver was the leading cause of sudden, unexpected death, accounting for 27.7% of the sudden deaths, while 21.8% were due to arteriosclerotic heart disease.
Therapeutic serum concentrations of human alpha-1 antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes*1
Authors: M KAY
Journal: Hepatology (1995)

Alpha-1-antitrypsin is a relatively common genetic deficiency that results in early emphysema. The liver as the natural source of most alpha-1-antitrypsin synthesis was the target organ selected for gene replacement therapy studies. Previous work used recombinant retroviral vectors that encode the human alpha-1-antitrypsin cDNA for ex vivo and direct in vivo transduction of hepatocytes in dogs and rodents. This approach led to low levels of the human protein in the serum of recipients. In this study, recombinant adenoviral vectors that express the human alpha-1-antitrypsin cDNA under the transcriptional control of the phosphoglycerate kinase (PGK) or RSV-LTR promoters have been constructed and used for the direct transduction of mouse hepatocytes in vivo. The animals transduced with the recombinant adenoviral vectors had therapeutic serum levels of human alpha-1-antitrypsin of up to 700 μg/mL. Thus, adenovirus-mediated gene transfer of the hAAT cDNA into the liver was able to produce therapeutic serum concentrations of protein.
A multiphasic study of lower-extremity amputees
Authors: K. H. Kohn
Journal: JAMA (1967)

Sixty-five lower-extremity amputees were selected for prosthetic training. Fifty-eight completed the program, which was modified to include use of a training pylon and to permit electrocardiographic monitoring. All patients were rated four times in four areas: cardiac functional capacity, peripheral vascular status of the remaining leg, functional ability achieved, and several psychological aspects. All patients improved in physical functioning with a prosthesis regardless of cardiac disease, peripheral vascular disease of the remaining leg, osteoarthritis, or low intellectual ability. Long delay, even 12 months or more, from amputation to prosthesis did not adversely influence gain in function. Geriatric amputees can achieve independent living outside of custodial care institutions if given properly modified prosthesis and prosthetic training.
Clinical sense, social sense, common sense
Authors: D. L. Wilbur
Journal: JAMA (1969)

As I address this House of Delegates for the last time as President of the Association, let me express my great pride in the medical profession and the American Medical Association. I am grateful to hundreds of members of the Association and to its staff who during the past year have so ably and effectively pushed toward its goals and have helped me so much. I am indeed grateful. It is not my purpose to review the accomplishments and the disappointments since June 1968. Instead, I would like to discuss some thoughtful and practical considerations of the road ahead, particularly as medicine relates to society and to government. Medicine is really in its infancy! Medicine in human service has almost unlimited possibilities. As it becomes increasingly scientifically based—as it surely will in the years ahead—we and our successors will see fantastic developments, many of them unpredictable. One can predict that
Correction: Low Levels of Her2/neu Expressed by Ewing's Family Tumor Cell Lines Can Redirect Cytokine-Induced Killer Cells
Journal: Clinical Cancer Research (2015)

In this article (Clin Cancer Res 2005;11:4561–70), which was published in the June 15, 2005, issue of Clinical Cancer Research (1), one of the authors' names was misprinted. The corrected name should read as follows: "Mobin Karimi." The publisher regrets this error.
Crack Cocaine Abuse: An Epidemic with Many Public Health Consequences
Authors: J. W. Cornish
Journal: Annual Review of Public Health (1996)

In the mid-1980s a new, smokable form of cocaine, called crack, was introduced in the United States. Soon thereafter, it became apparent that crack cocaine abuse was a serious and important public health concern. Over the past several years, crack cocaine use has increasingly been associated with a myriad of immediate and long-term adverse effects. Duing this same period, crack cocaine use has progressively moved away from experimentation and recreational use to chronic and compulsive drug use.
Doctors: still disorganised but still trusted
Authors: Richard Smith, Gaby Shockley, Jane Smith, Annabel Ferriman, Judy Jones, Kamran Abbasi, Alison Tonks General, Trish Groves, Sandra Goldbeck-Wood, Tessa Richards, Sharon Davies, Trevor Jackson, Rhona Macdonald, Andrew Woodward, John Gary, Bryan Standing, Susan Minns, Marita Batten Picture, Jan Croot, Abi Berger, Margaret Cooter, Jackie Annis, Greg Cotton, Liz Payne, Miriam Pinchuk, Barbara Squire, Julia Thompson, Tony Delamothe, Christopher Martyn, Marcus Müllner, Roger Robinson, Tony Smith, Ron Davis, Jennifer Leaning, Rajendra Kale, John Roberts, Gwen Adshead, James Barrett, Nick Booth, Nicky Britten, Peter Cantillon, Teifion Davies, Robin Ferner, Ian Forgacs, Trisha Greenhalgh, Marcia Hall, Iona Heath, Richard Hobbs, Linda Hutchinson, David Jewell, Kevin Jones, Duncan Keeley, Tim Lancaster, Ben Lloyd, Diana Lockwood, Azeem Majeed, Michael O'brien, John Rees, Nicholas Steel, Sheila Teasdale, Tom Treasure, Chris Van Weel, John Williams, Diana Wood, Jeremy Wyatt, Doug Altman, Mike Campbell, Tim Cole, Jon Deeks, Stephen Evans, Hazel Inskip, Julie Morris, Gordon Murray, Jackie Connor, Andy Josephides, Bernadette Kearney Display, Catherine Harding-Wiltshire, Simon Walker, Alan Walker, Nick Gray, Sheila Rowe, David Evans, Jeremy Anderson, Mary Australia, Lisa Baker, Donald Bero, Nicholas Berwick, Luis-Gabriel Christakis, Michael Cuervo, Paul Dixon, Roger Australia, Peter Goss, Tony Denmark, Yuan Grabham, China Gu, Canada Haynes, Georgia Kirtava, Cindy Austria, Hong Lam, Leonard Kong, Israel Lebovici, Michel Liberati, France Lievre, Daniel Mulrow, Gretchen Purcell, Lois Quam, Paula Rochon, Canada Sepulveda, Rosalind Smyth, Fiona Stanley, Paul Stewart, Tessa Torres-Edejer, Susumu Wakai, Hugh Japan
Journal: BMJ (2001)
Missing Panels in Figure 1
Authors: Steven Narod, Vasily Giannakeas, Victoria Sopik
Journal: JAMA Oncology (2020)

Steven T. Bird, PhD, PharmD, MS; Fang Tian, PhD, MHS, MPH; Natasha Flowers, BA; Donna Przepiorka, MD, PhD; Rongrong Wang, MPH; Tae-Hyun Jung, PhD; Zebulin Kessler, BS; Corinne Woods, RPh, MPH; Bo Kim, BA; Barry W. Miller, MS, CRNP; Michael Wernecke, BA; Clara Kim, PhD; Stephen McKean, PhD; Kate Gelperin, MD, MPH; Thomas E. MaCurdy, PhD; Jeffrey A. Kelman, MD; David J. Graham, MD, MPH
The effect of the National Rural Health Mission on health services and outcomes for childbirth in India: a retrospective analysis of survey data
Authors: Amit M Prasad, Salima Bhatia, Ritu Agrawal
Journal: The Lancet Global Health (2013)

BackgroundPublic health in India is the responsibility of provincial governments. In 2005, the Indian Government launched the National Rural Health Mission (NRHM) to focus on bottom-up planning and flexible funding to address the local needs. We assessed the effect of interventions introduced under the NRHM on childbirth health services and outcomes in states with poor health indicators.MethodsWe extracted data for infant mortality rate and total fertility rate from sample registration surveys done in 2001, 2005, and 2011. We also extracted data for institutional deliveries and availability of infrastructure and human resources from the National Family Health Survey III (2005–06), the Annual Health Survey (2010–11), and Rural Health Statistics (2012). We assessed changes in these data before and after the introduction of the NRHM in eight Empowered Action Group states—ie, states with poor health indicators.FindingsMedian infant mortality rate fell by 14·6% in 2001–06, compared with 20·9% in 2006–11. Likewise, median total fertility rate fell by 10·3% in 2001–06 compared with 14·3% in 2006–11 (appendix). Although the availability of public health facilities changed little (78 305 in 2005, 81 058 in 2012), the availability of nursing staff increased from 10 633 in 2005, to 16 079 in 2012. The availability of auxiliary nurse midwives also rose, from 50 837 in 2005, to 66 001 in 2012. The proportion of institutional deliveries increased from 23% in 2005–06, to 49% in 2010–11.InterpretationThe NRHM provides a model to efficiently provide health care to people in low-resource settings.FundingNone.
Comparison of DNA Adducts from Exposure to Complex Mixtures in Various Human Tissues and Experimental Systems
Authors: Joellen Lewtas, Judy Mumford, Richard B. Everson, Barbara Hulka, Tim Wilcosky, Walter Kozumbo, Claudia Thompson, Michael George, Lubomir Dobias, Radim Sram, Xueming Li, Jane Gallagher
Journal: Environmental Health Perspectives (1993)

DNA adducts derived from complex mixtures of polycyclic aromatic compounds emitted from tobacco smoke are compared to industrial pollution sources (e.g., coke ovens and aluminum smelters), smoky coal burning, and urban air pollution. Exposures to coke oven emissions and smoky coal, both potent rodent skin tumor initiators and lung carcinogens in humans, result in high levels of DNA adducts compared to tobacco smoke in the in vitro calf thymus DNA model system, in cultured lymphocytes, and in the mouse skin assay. Using tobacco smoke as a model in human studies, we have compared relative DNA adduct levels detected in blood lymphocytes, placental tissue, bronchoalveolar lung lavage cells, sperm, and autopsy tissues of smokers and nonsmokers. Adduct levels in DNA isolated from smokers were highest in human heart and lung tissue with smaller but detectable differences in placental tissue and lung lavage cells. Comparison of the DNA adduct levels resulting from human exposure to different complex mixtures shows that emissions from coke ovens, aluminum smelters, and smoky coal result in higher DNA adduct levels than tobacco smoke exposure. These studies suggest that humans exposed to complex combustion mixtures will have higher DNA adduct levels in target cells (e.g., lung) as compared to nontarget cells (e.g., lymphocytes) and that the adduct levels will be dependent on the genotoxic and DNA adduct-forming potency of the mixture.
Contents
Authors: Saki Akou, Katsuhide Yamadera, Hisashi Fukuyama, Fumi Gomi, Siddharth Nath, Carl Shen, Alex Koziarz, Laura Banfield, Behnam Nowrouzi-Kia, Mark Fava, William Hodge, Benjamin Xu, David Friedman, Paul Foster, Yuzhen Jiang, Anmol Pardeshi, Beatriz Munoz, Mingguang He, Bobeck Modjtahedi, Jun Wu, Tiffany Luong, Nainesh Gandhi, Fen Fen Li, Yuzhou Zhang, Xiujuan Zhang, Benjamin Hon, Kei Yip, Shu Tang, Ka Kam, Alvin Young, Jia Li, Clement Tham, Chi Pang, Jason Dphil, Edin Yam, Gerard Barry, Yinxi Yu, Gui-Shuang Ying, Lauren Tomlinson, Juliann Lajoie, Marilyn Fisher, Gil Binenbaum, Naoya Nezu, Yoshihiko Usui, Akira Saito, Hiroyuki Shimizu, Masaki Asakage, Naoyuki Yamakawa, Kinya Tsubota, Yoshihiro Wakabayashi, Akitomo Narimatsu, Kazuhiko Umazume, Katsuhiko Maruyama, Masahiro Sugimoto, Masahiko Kuroda, Hiroshi Goto
Journal: Ophthalmology (2021)