tbuckley/cabot-search huggingface dataset:
AMA-RPS Resolutions Referred to the Board of Trustees
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Guides to the evaluation of permanent impairment. The hematopoietic system
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myocardial infarction due to postirradiation fibrosis of the coronary arteries. Case of successfully treated Hodgkin's disease with lower esophageal involvement
Authors: M. R. Dollinger
Journal: JAMA (1966)

COMPLICATIONS of radiation therapy, which are more severe and disabling than the primary disease, may develop in patients with Hodgkin's disease. The major disability in a patient who survived for 18 years after diagnosis was due to an extreme degree of postirradiation fibrosis, resulting in elephantiasis of the legs, and coronary artery occlusion and acute myocardial infarction secondary to radiation-induced coronary artery fibrosis. To our knowledge, this latter complication of radiation therapy has not been previously described in detail, only two cases having been briefly discussed by Pearson.<sup>1</sup> <h3>Report of a Case</h3> A diagnosis of Hodgkin's disease was made in this patient at the age of 23 (1943) by biopsy of enlarged right inguinal lymph nodes. Over the next three years, he received radiation therapy to the axillary, cervical, inguinal, and abdominal areas. Elephantiasis and chronic cellulitis of the legs and scrotum developed, which was not improved after a
Nods for Atezolizumab and Nivolumab from FDA
Journal: Cancer Discovery (2016)

The FDA has conditionally approved atezolizumab, the first PD-L1 inhibitor, for metastatic urothelial carcinoma, along with a companion diagnostic, the Ventana PD-L1 (SP142) assay. The agency has also expanded nivolumab's indications to include classical Hodgkin lymphoma, making this PD-1 inhibitor the first to be approved for a hematologic malignancy.
Libri
Authors: J. Foudraine, A. Maeder, Benjamin B. Wolman, J.H. Schultz, N.N. Dracoulides, Harold Kenneth Fink, Pierre-B. Schneider, R. Cheli, F. Giberti, M. Dodero, R. Laforgue, Joost A.M. Meerloo
Journal: Psychotherapy and Psychosomatics (1961)
Renal functional reserve and nitric oxide in patients with compensated liver cirrhosis
Authors: R Woitas
Journal: Hepatology (1997)

To investigate the role of nitric oxide (NO) with respect to kidney function and liver cirrhosis, we evaluated renal function, as well as cyclic guanosine monophosphate (cGMP) and NOx (nitrite/nitrate [NO3− /NO2−]) as indirect markers of NO formation in plasma and urine at rest and during amino acid (aa)-induced glomerular hyperfiltration in patients with Child A liver cirrhosis and portal hypertension (n = 12), and in healthy controls (n = 10). Baseline filtration rate (GFR) and effective renal plasma flow (ERPF) were significantly lower in patients with cirrhosis than in controls (GFR: mean 88 ± SD 16 mL/min vs. 106 ± 15 mL/min, P = .01, ERPF: 477 ± 93 vs. 561 ± 72 mL/min, P = .002). In both groups amino acid (aa) infusion increased GFR, ERPF, as well as cGMP and urinary NOx. Changes in GFR were similar in cirrhotic patients and controls (28.3% ± 14% in cirrhotics and 26% ± 11% in controls), but the degree of aa-induced changes in ERPF was more marked in patients with liver cirrhosis (31.8% ± 17% vs. 18.6% ± 12%, P = .02). Plasma levels of NOx and cGMP were similar in either group at baseline and during aa infusion, whereas NOx and cGMP excretion in cirrhotics was constantly 14% to 24% lower than in the control group. We conclude that patients with compensated liver cirrhosis and portal hypertension already have an impaired kidney function. In addition our data suggest a cirrhosis-related dissociation between ERPF and GFR during aa stimulation. Further studies are warranted to find out whether a local imbalance between vasoconstrictors and vasodilators, e.g., decreased local NO formation, plays a key role for this phenomenon.
Elbow dislocation with radial head fracture
Authors: O. E. Aufranc
Journal: JAMA (1966)

Dr. Joseph L. Shaw: A 48-year-old woman fell on the sidewalk while attempting to avoid being struck by a bicycle. She thinks that she landed directly on the elbow rather than on the hand. She was seen in the emergency ward at the Massaschusetts General Hospital less than an hour following her injury. Results of a physical examination were normal except for the right elbow which was swollen, tender, and deformed. Circulation and sensation in the extremity were intact, but the elbow was obviously dislocated posteriorly. Dr. Aufranc: Dr. Edward Riseborough will discuss the x-ray films and the management of this severe elbow injury. Dr. Edward J. Riseborough: This patient has sustained a posterior dislocation of the elbow joint with fracture of both the coronoid process of the ulna and the lateral margin of the radial head (Fig 1). Fortunately, the coronoid process fracture is small, the fragment measuring about
History, Reproduction
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The "British system" of heroin maintenance
Authors: Thomas J. Kaiser
Journal: JAMA (1973)

<h3>To the Editor.—</h3> In the article discussing the 'British system' of heroin maintenance (223:539, 1973) Dr. Edward Lewis, Jr., presented an appealing statistical basis for the adoption on a limited basis for such a system in the United States. He described a country that apparently has stabilized its addict population, that has no significant crime problem associated with addicts, and that has fewer medical complications secondary to illicit drug use. What is disconcerting is that he contradicted this evidence in four of his five conclusions, returning to the 'wait and see' attitude that has paralyzed rehabilitative attempts. He supported his conclusions by noting differences between Britain and the United States, ignoring completely the more compelling and relevant similarities, such as parallel increase in rates of addiction in the 60s, common use of mainlining as a method of administration, preponderance of addicts in urban areas, and failure of other rehabilitative methods.
A hitchhiker's guide to antisense and nonantisense biochemical pathways
Authors: A Branch
Journal: Hepatology (1996)

Antisense pharmaceutical research has sought to provide drugs that would yield effective therapies for diseases resulting from the production of deleterious proteins. The original concept was straightforward: eliminate production of unwanted proteins, such as oncogenic proteins, by blocking the function of their mRNAs; and block their mRNAs by adding “antisense” nucleic acids that bind them through complementary base pairing. However, it has proven difficult to develop clinically useful antisense strategies. Conventional antisense nucleic acids are large, highly charged, complex molecules that interact with a wide variety of unintended cellular and microbial components, often causing “nonantisense effects.” It is now clear that a broad knowledge of nucleic acid biochemistry will be needed to optimize antisense molecules for use in patients. The efficacy of naturally occurring antisense molecules and the success of antisense agricultural strategies prove that antisense approaches can be powerful and specific. Pharmaceutical antisense research can be expected to yield many valuable products once sufficient information about antisense mechanisms has been gathered and applied. This article explains the biochemical events that give rise to both antisense and nonantisense effects and provides guidelines for designing and evaluating antisense experiments.
Contents
Authors: Alex Ferdi, Vuong Nguyen, Daniel Gore, Bruce Allan, Jos Rozema, Stephanie Watson, Matthew Duggan, Jennifer Rose-Nussbaumer, Charles Lin, Ariana Austin, Paula Labadzinzki, Winston Chamberlain, Moon Lee, Jiangxia Wang, David Friedman, Michael Boland, Carlos De Moraes, Pradeep Ramulu, Andrew Anderson
Journal: Ophthalmology (2019)
Optimizing GH Therapy in Adults and Children
Authors: W. M. Drake
Journal: Endocrine Reviews (2001)

Until the advent of modern neuroradiological imaging techniques in 1989, a diagnosis of GH deficiency in adults carried little significance other than as a marker of hypothalamo-pituitary disease. The relatively recent recognition of a characteristic clinical syndrome associated with failure of spontaneous GH secretion and the potential reversal of many of its features with recombinant human GH has prompted a closer examination of the physiological role of GH after linear growth is complete. The safe clinical practice of GH replacement demands a method of judging overall GH status, but there is no biological marker in adults that is the equivalent of linear growth in a child by which to judge the efficacy of GH replacement. Assessment of optimal GH replacement is made difficult by the apparent diverse actions of GH in health, concern about the avoidance of iatrogenic acromegaly, and the growing realization that an individual's risk of developing certain cancers may, at least in part, be influenced by cumulative exposure to the chief mediator of GH action, IGF-I. As in all areas of clinical practice, strategies and protocols vary between centers, but most physicians experienced in the management of pituitary disease agree that GH is most appropriately begun at low doses, building up slowly to the final maintenance dose. This, in turn, is best determined by a combination of clinical response and measurement of serum IGF-I, avoiding supraphysiological levels of this GH-dependent peptide. Numerous studies have helped define the optimum management of GH replacement during childhood. The recent requirement to measure and monitor GH status in adult life has called into question the appropriateness of simplistic weight- and surface area-based dosing regimens for the management of GH deficiency in childhood, with reliance on linear growth as the sole marker of GH action. It is clear that the monitoring of parameters other than linear growth to help refine GH therapy should now be incorporated into childhood GH treatment protocols. Further research will be required to define the optimal management of the transition from pediatric to adult GH replacement; this transition will only be possible once the benefits of GH in mature adults are defined and accepted by pediatric and adult endocrinologists alike.
AN OBJECT LESSON IN THE ADVANTAGES OF ORGANIZATION.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ERRORS IN OBSERVATION.
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Guidelines for organization of critical care units
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Clinical Screening Tool Identifies Autoimmune Diabetes in Adults
Authors: S. Fourlanos
Journal: Diabetes Care (2006)

OBJECTIVE—Latent autoimmune diabetes in adults (LADA) is defined as adult-onset diabetes with circulating islet antibodies but not requiring insulin therapy initially. Diagnosing LADA has treatment implications because of the high risk of progression to insulin dependency. Currently, there are no recommendations for islet antibody testing in adult-onset diabetes. In this study, we aimed to develop a clinical screening tool to identify adults at high risk of LADA who require islet antibody testing.
Reply
Authors: F.M. Tatnall, H.J. Dodd, I. Sarkany
Journal: British Journal of Dermatology (1986)

Journal Article Reply Get access F.M. Tatnall, F.M. Tatnall Department of Dermatology, Royal Free Hospital, London NW3 2QG, U.K. Search for other works by this author on: Oxford Academic Google Scholar H.J. Dodd, H.J. Dodd Department of Dermatology, Royal Free Hospital, London NW3 2QG, U.K. Search for other works by this author on: Oxford Academic Google Scholar I. Sarkany I. Sarkany Department of Dermatology, Royal Free Hospital, London NW3 2QG, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue 2, 1 August 1986, Pages 250–251, https://doi.org/10.1111/j.1365-2133.1986.tb05729.x Published: 01 August 1986
Liver - basic
Authors: Prostaglandin Rolfhoffmann, Hans-Peter Henninger, Agnes Schulze-Specking, Karl Decker
Journal: Gut (1993)

Interleukin-6 is a multifunctional cytoline involved in a variety of re- gulatory immune responses.It is the principle cytokine responsible for regulation of the acute-phase proteins by the liver.This concept implies coordinated expression of this cytokine, their effector genes and the fine tuning of the specific receptors.In accordance to-the-multifunctiona properties of IL6, low numbers of specific receptors were reported on hepatocytes.However, know- ledge accumulates regarding IL-6 effects on liver target cells, while little is known about possible effector cells.Male Wistar rats (250-300 g) fed ad libitum were used throughout.Kupffer ceLs (KC) were isolated by pronase-collagenase perfusion followed by centrifugal elutriation.Kupffer cells were maintained in primary culture with RPMI 1640 medium containing 30% heat-inactivated newborn-calf serum.After 72 h in culture, they were exposed for 0, 1 h, 2h, 4h, 8h, 16h and 24h to 1OOng/ml LPS (S. minnesota), TNF-a, IL-1i, EFN-y, IL-6, PMA, dexame- thasone, PGE2 and cAMP.Total RNA was subsequently isolated, and IL-6 receptor mRNA expression was determined by semiquantitative PCR.For this purpose high-performance liquid chromatography (HPLC) was used to quantitate PCR products.We found downregulation of 1L-6 receptor mRNA in Kupffer cells.which were stmulated with IL-6, LPS, TNF-a, IL-1B, IFN-y and phorbol ester (PMA).Since we detected increased mRNA levels for IL-6 after LPS and IFN-y stimulation, our results.indicatean autocrine mechanism by which KC downregulate their surface receptors for IL-6.Preliminary results for IL- 18, TNF-a and PMA show a similar tendency.Surprisingly IL-6 receptor mRNA was upregulated after PGE,, cAMP and dexamethasone but was unaffected after PGD2.In the microenvironment of the hepatic sinusoids the Kupffer cells (KC) are as the resident macrophages the most potential source of IL-6 during inflammation.According to this concept, IL-6 gene expression and IL-6 release from KC into the hepatic sinusoids is likely under coordinated control.Our results demonstrate fine tuning of IL-6 receptor mRNA which is very likely important to achieve optimal immune responses.0II/3 313 OII/4 247 PARADOXICAL UP-REGULATION OF CHOLESTEROL 7a-HYDROXYLASE (C7aH) FOLLOWING COMMON BILE DUCT LIGATION (CBDL).Z.R. was maximal 30.2±3.6%(n=3).In sununary, we could demonstrate that the hepatic acute phase protein al-AT reduced in high physiological concentrations the cell growth and proliferation of the hepatic tumor cells HepG2 by interfering with tf mediated iron uptake.S3
Severe hypersensitivity reactions associated with allopurinol
Authors: R. M. Mills
Journal: JAMA (1971)

Two patients developed fever, dermatitis, renal insufficiency, and eosinophilia, three and five weeks after beginning therapy with allopurinol. The clinical, laboratory, and histologic findings were compatible with a severe hypersensitivity reaction. Both patients required long-term corticosteroid therapy (more than six and four months, respectively) to control their symptoms. These observations suggest that hypersensitivity to allopurinol can produce a severe, prolonged, or potentially fatal illness.
Epigenetic basis of monocyte dysfunction in severe alcoholic hepatitis
Authors: Weichselbaum Laura, Azouz Abdulkader, Kinga Smolen, Das Jishnu, Splittgerber Marion, Antonia Lepida, Christophe Moreno, Jonas Schreiber, Sersté Thomas, Trépo Eric, Libert Frederick, Thierry Gustot, Goriely Stanislas
Journal: Journal of Hepatology (2020)