tbuckley/cabot-search huggingface dataset:
Immunologic Aspects of Renal Disease
Authors: Julian L. Ambrus
Journal: JAMA (1997)

The kidney can become involved in immune-mediated diseases through 3 mechanisms. It can be the primary target of antibody-mediated injury. Goodpasture syndrome, with antibodies directed at the glomerular basement membrane, is an example of this type. The kidney can be injured by immune complexes that are trapped in the kidney and cause local inflammation. Examples include systemic lupus erythematosus and IgA nephropathies. Finally, the kidney can be injured by immune responses initiated in other organs. In Wegener granulomatosis, inflammation begins in the airway but results in glomerulonephritis. Currently available therapies lack efficacy and specificity. New therapies based on pathophysiology are being developed in animal models.
Counseling and Antibody Testing to Prevent HIV Infection
Authors: Barbara A. DeBuono
Journal: JAMA (1989)

<h3>To the Editor. —</h3> Routine serological screening for human immunodeficiency virus (HIV) infection has been recommended for patients attending sexually transmitted disease (STD) clinics.<sup>1-3</sup>Blinded serological testing of STD clinics' clients can serve as an accurate assessment of seroprevalence in this well-defined population.<sup>3,4</sup> <h3>Study.—</h3> In anonymous and blinded screening of 1025 consecutive patients attending Rhode Island state-supported clinics for STDs between January 14 and May 20, 1988, we found an HIV seroprevalence rate of 3.1%. The clinic serves an urban population. Two thirds of the study population were men and one third were women. Of the 32 HIV-seropositive clients, 29 (91%) were men and only 3 (9%) were women. Seroprevalence in men was higher than that in women, 4% vs 1%. The age distribution of HIV-positive clients (median age, 32 years) was older than that of the study population (median age, 27 years). The median age of HIV-positive
Injury Caused by 'Break Dancing'
Authors: Philip J. Goscienski
Journal: JAMA (1984)

<h3>To the Editor.—</h3> The current dance fad known as "break dancing" is characterized by spinning and tumbling movements supported by the arms, spinning toplike on the back, and forming a bridge supported by the head and heels. The surmise that "breaking" is likely to result in occasional injury is a correct one. We have seen what appears to be a specific injury related to break dancing and note several other injuries that have been treated by local practitioners. <h3>Report of a Case.—</h3> An 11-year-old boy complained of pain in the midback. His mother observed swelling in the area, and he was taken to a practitioner in Mexico, who aspirated blood from the mass. The patient was then brought to the University of California, San Diego, Medical Center. Physical examination results were normal except for swelling of the area between and adjacent to the dorsal spine of T-10 to L-1 measuring
French-English Medical Dictionary.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Opioid Receptors and Endogenous Opioids in Diverse Human and Animal Cancers&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Ian S. Zagon, Patricia J. McLaughlin, Steven R. Goodman, Randy E. Rhodes
Journal: JNCI Journal of the National Cancer Institute (1987)

Receptor binding studies demonstrated specific high-affinity, saturable binding of a number of opioid ligands to a wide variety of neural and nonneural human and animal tumors. Radioimmunoassays revealed the presence of β-endorphin and methionine-enkephalin in these tumors. Both methionine- and leucine-enkephalin were detected in tumor tissue by immunocyto-chemistry, with immunoreactivity related to the cortical cytoplasm of tumor cells, but not to cell nuclei. Endogenous opioids and receptors were found in benign and malignant tumors representative of ectodermal, mesodermal, and endodermal origin. Receptors and endogenous opioid peptides were present in tumors from many different species, including those transplanted into nude mice. These results suggest that opioid receptors and endogenous opioids are fundamental features of human and animal cancers.
Systemic Administration of Human Leukocyte Interferon to Melanoma Patients. I. Effects on Natural Killer Function and Cell Populations&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;, &lt;xref ref-type="fn" rid="fn3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1982)

Natural killer (NK) cytotoxicity was assessed against K562 targets in 14 melanoma patients who received daily im doses of human leukocyte interferon (IFN) for 42 consecutive days. The most common pattern of NK activity was a decline from pretreatment levels 1 day after initiation of treatment, followed by increasing cytotoxicity with peak activity at day 7 and a subsequent gradual decline to pretreatment levels during the remaining weeks of treatment. This pattern was particularly apparent in patients who received 3 × 106 or 9 × 106 U IFN/day, while patients who received 1 × 106 U IFN/day tended to lack the decline at day 1 and maintained the elevated NK activity past day 7. Changes in NK activity could not be related to changes in absolute lymphocyte counts; to proportions of cells bearing membrane receptors for sheep red blood cells, of cells bearing membrane receptors for erythrocyte-antibody-complement, or of cells bearing FCγ receptor; or to clinical response to IFN.
Sexual Practices and Risk of Infection by the Human Immunodeficiency Virus
Authors: Warren Winkelstein
Journal: JAMA (1987)

The San Francisco Men's Health Study is a prospective study of the epidemiology and natural history of the acquired immunodeficiency syndrome in a cohort of 1034 single men, 25 to 54 years of age, recruited by multistage probability sampling. At entry, June 1984 through January 1985, the seropositivity rate for human immunodeficiency virus (HIV) infection among homosexual/bisexual study participants was 48.5%. No heterosexual participants were HIV seropositive. Among homosexual/bisexual men reporting no male sexual partners in the two years before entry into the study, seropositivity was 17.6%. For those reporting more than 50 partners, seropositivity was 70.8%. Only receptive anal/genital contact had a significantly elevated risk of HIV infection. Douching was the only ancillary sexual practice that contributed significantly to risk of infection. (<i>JAMA</i>1987;257:321-325)
Annual Review of Biochemistry
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Awards, Appointments, Announcements
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Awards, Appointments, Announcements Get access JNCI: Journal of the National Cancer Institute, Volume 83, Issue 20, 16 October 1991, Pages 1447–1448, https://doi.org/10.1093/jnci/83.20.1447 Published: 16 October 1991
When Doctors are Patients
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Glaucoma detection in Florida
Authors: J. E. Frydman
Journal: JAMA (1966)

A permanent glaucoma screening program is being carried out in four Florida counties. In this program, screening is done five days a week throughout the year. Of the 67,193 persons screened as of December 1965, 870 unknown cases of glaucoma and 115 cases of borderline glaucoma were diagnosed, amounting to an overall incidence of 1.4% and 0.2% respectively. The largest percentage of diagnosed glaucoma was in the 55 to 74 age groups. The incidence of glaucoma in Negroes was twice as high as in white persons, and the incidence in persons with a positive family history amounted to 6.4%. Among the advantages in a permanent screening program are early detection of glaucoma and possible prevention of the blindness which can result from it.
Formes chirurgicales de la tuberculose intestinale
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Textbook of Surgical Treatment Including Operative Surgery.
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ASSOCIATION OF AMERICAN MEDICAL COLLEGES.
Authors: F C Zapffe
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Introduction to Physiological Chemistry
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute Intoxication With Methylchloroform
Authors: Richard D. Stewart
Journal: JAMA (1966)

Methylchloroform (1,1,1-trichloroethane) is a widely used solvent substitute for carbon tetrachloride. Excessive absorption of methylchloroform through the gastrointestinal tract or lung produces central nervous system (CNS) depression proportional to the amount absorbed. Ingestion is followed by vomiting and diarrhea. Mild liver and kidney dysfunction may occur transiently following recovery from CNS depression. The diagnosis of exposure is established by specifically identifying the solvent in the expired breath. Serial breath analyses allow the estimation of the total amount absorbed. The treatment is supportive to combat the effects of CNS depression. The principles of diagnosis and treatment are illustrated by the case of a man, aged 47, who accidentally ingested one ounce of methylchloroform.
No-Tobacco Day Targets Workplace as UN World Health Campaign Moves Into Fifth Year
Authors: Phil Gunby
Journal: JAMA (1992)

SUNDAY is the fifth World No-Tobacco Day. The sponsoring World Health Organization says this year's theme is "Tobacco-free Workplaces." The World Health Organization is an autonomous unit within the United Nations system with headquarters in Geneva, Switzerland. Hiroshi Nakajima, MD, PhD, the organization's director-general who is committed to major international reductions in tobacco use, has made recent appearances in the United States including at the John Hopkins University School of Hygiene and Public Health's 75th anniversary program in Baltimore, Md, late last month. He says that the World Health Organization already is appealing to public officials and "to the civic sense of individuals" to halt the use of tobacco. Now, he says, "on May 31, we're turning to workers and employers." So, apparently, is at least one tobacco company. It's reported that Philip Morris Inc is sponsoring 15 country music concerts this year, 10 of which are to be on
Inflammatory Bowel Disease Posters
Authors: L.M. Edmond, J.H. Cummings
Journal: Gut (2001)

Conclusions:In-patients with diarrhoea usually have a noninfectious cause for their condition.In the most of these, the cause is iatrogenic.When the cause is enteric infection, by far the commonest cause is C. diYcile (not routinely tested for), with all other pathogens (routinely tested for) being very uncommon.All in-patients with hospital-acquired diarrhoea should be tested for Clostridium diYcile infection routinely.
The Platelet, the Patient, and Periprocedural Infarction During Percutaneous Transluminal Coronary Angioplasty
Authors: David L. Fischman
Journal: JAMA (1997)

It is estimated that in 1997,1 million percutaneous coronary interventions will be performed worldwide. This dramatic growth in nonsurgical coronary revascularization has primarily occurred because of the development of innovative techniques and catheters, including coronary stents. Despite this growth and the improved success rates for these procedures, acute ischemic complications following balloon angioplasty remain an important problem associated with significant morbidity and mortality.<sup>1,2</sup>In addition, postprocedure elevation of cardiac enzymes has been associated with an increased incidence of late adverse cardiac events even when successful revascularization is achieved.<sup>3</sup>Kong et al<sup>4</sup>recently reported a more than 2-fold increase in late cardiac mortality (mean duration &gt;3.5 years) in patients with a mild elevation (1.5 × upper limit of normal) in the creatine kinase enzyme following balloon angioplasty. In this study, creatine kinase elevation predicted an increased risk of late mortality, which was independent of clinical variables, severity of
Postcoital Antimicrobial Prophylaxis for Recurrent Urinary Tract Infection
Authors: Ann Stapleton
Journal: JAMA (1990)

We conducted a randomized, double-blind, placebo-controlled study to determine the efficacy of postcoital antibiotic prophylaxis in healthy young women prone to recurrent urinary tract infections. Sixteen patients were randomized to receive postcoital administration of a combination product of trimethoprim and sulfamethoxazole, while 11 received postcoital placebo. The treatment groups were similar with respect to age, parity, diaphragm use, history of lifetime urinary tract infections, frequency of intercourse, and number of lifetime sexual partners. In over 6 months of observation, postcoital administration of trimethoprimsulfamethoxazole was highly effective in preventing recurrent urinary tract infections. Nine of 11 patients who took the placebo developed urinary tract infections (infection rate, 3.6 per patient-year), compared with only two of 16 patients who received postcoital trimethoprim-sulfamethoxazole (infection rate, 0.3 per patient-year). Postcoital administration of trimethoprim-sulfamethoxazole was effective in patients with both low (two or fewer times per week) and high (three or more times per week) intercourse frequencies. Side effects were few and compliance was excellent. We conclude that postcoital trimethoprim-sulfamethoxazole is a safe, effective, and inexpensive approach to management of recurrent urinary tract infections in young women. (<i>JAMA</i>. 1990;264:703-706)
Precursor Lesions in Familial Melanoma
Authors: Ronald R. Reimer
Journal: JAMA (1978)

In seven consecutive melanoma-prone families, pigmented lesions with distinctive clinical and histologic characteristics occurred in 18 of 20 melanoma patients (90%) and 24 of 43 first-degree relatives (56%). Recognition of these lesions led to the detection of early-stage melanoma in six family members. This syndrome appears to represent an autosomal dominant trait and may serve as a cutaneous marker to identify persons at high risk for melanoma. (<i>JAMA</i>239:744-746, 1978)