Thrombopoietin Is a Platelet Growth Factor That May Lessen the Need for Platelet Transfusions after Chemotherapy for Cancer
Journal: Annals of Internal Medicine (2000)

Summaries for Patients7 March 2000Thrombopoietin Is a Platelet Growth Factor That May Lessen the Need for Platelet Transfusions after Chemotherapy for CancerSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-5-200003070-00029 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Platelets are tiny cells produced in the bone marrow and released into the bloodstream, where they help the blood to clot. The risk for bleeding is therefore increased in patients with low platelet counts. Many cancer chemotherapies interfere with platelet production; a low platelet count (thrombocytopenia) is therefore a common side effect of chemotherapy. Platelet transfusions are used to treat dangerously low platelet counts. Unfortunately, such transfusions can result in transfusion reactions or infection; they are also quite expensive. Moreover, some patients stop responding to platelet transfusions after ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Recombinant Human Thrombopoietin Attenuates Carboplatin-Induced Severe Thrombocytopenia and the Need for Platelet Transfusions in Patients with Gynecologic Cancer.”. It is in the 7 March 2000 issue of Annals of Internal Medicine (volume 132, pages 364-368). The authors are S. Vadhan-Raj, C.F. Verschraegen, C. Bueso-Ramos, H.E. Broxmeyer, A.P. Kudelka, R.S. Freedman, C.L. Edwards, D. Gershenson, D. Jones, M. Ashby, and J.J. Kavanagh.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoRecombinant Human Thrombopoietin Attenuates Carboplatin-Induced Severe Thrombocytopenia and the Need for Platelet Transfusions in Patients with Gynecologic Cancer Saroj Vadhan-Raj , Claire F. Verschraegen , Carlos Bueso-Ramos , Hal E. Broxmeyer , Andrzej P. Kudelka , Ralph S. Freedman , Creighton L. Edwards , David Gershenson , Dennie Jones , Mark Ashby , and John J. Kavanagh Metrics 7 March 2000Volume 132, Issue 5Page: 364KeywordsBone marrowCancer chemotherapyChemotherapyGrowth factorsGynecologic cancersHemorrhageOvarian cancerPlateletsThrombosisUterus ePublished: 15 August 2000 Issue Published: 7 March 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...