tbuckley/cabot-search huggingface dataset:
A 50-year-old woman with spinal stenosis
Authors: D. Mazanec
Journal: JAMA (1996)

<h3>To the Editor.</h3> —We read with interest the discussion of spinal stenosis by Dr Garfin in Clinical Crossroads.<sup>1</sup>Indeed, symptomatic spinal stenosis is an increasingly recognized clinical problem, particularly in elderly patients. Nonoperative treatment options are of considerable interest because, as noted by Garfin, successful long-term surgical outcomes are seen in only 70% and reoperation may be required in 10% to 20% of patients. Though the nonoperative literature is sparse and largely uncontrolled, additional nonsurgical therapeutic options not discussed in the article deserve mention. Exercise-oriented physical therapy based on the McKenzie approach has recently been studied in an open, short-term, uncontrolled trial of patients with symptomatic lumbar canal stenosis.<sup>2</sup>At 12 weeks' follow-up, improvement in at least 1 outcome variable—pain score, Roland functional disability score, walking distance, or standing time—was noted in 58% of the patients. Thirty-three percent of the patients noted improvement in at least 2 variables.
Apoptosis of myocardial cell is associated with the abnormal signal-averaged ECG in patients with idiopathic dilated cardiomyopathy
Authors: T. Yamada, M. Fukunami, T. Shimonagata, K. Kumagai, S. Sanada, H. Ogita, Y. Asano, N. Hoki
Journal: Journal of the American College of Cardiology (1998)
Childhood energy intake and adult mortality from cancer: the Boyd Orr cohort study
Journal: BMJ (1998)

Objective: To examine the relation between energy intake in childhood and adult mortality from cancer.Study design: Cohort study.Setting: 16 rural and urban centres in England and Scotland.Subjects: 3834 people who took part in Lord Boyd Orr's Carnegie survey of family diet and health in prewar Britain between 1937 and 1939 who were followed up with the NHS central register.Standardised methods were used to measure household dietary intake during a one week period.Main outcome measures: Cancer mortality.Results: Significant associations between childhood energy intake and cancer mortality were seen when the confounding effects of social variables were taken into account in proportional hazards models (relative hazard for all cancer mortality 1.15 (95% confidence interval 1.06 to 1.24), P = 0.001, for every MJ increase in adult equivalent daily intake in fully adjusted models).This effect was essentially limited to cancers not related to smoking (relative hazard 1.20; 1.07 to 1.34; P = 0.001), with similar effects seen in men and women. Conclusion:This positive association between childhood energy intake and later cancer is consistent with animal evidence linking energy restriction with reduced incidence of cancer and the association between height and human cancer, implying that higher levels of energy intake in childhood increase the risk of later development of cancer.This evidence for long term effects of early diet confirm the importance of optimal nutrition in childhood and suggest that the unfavourable trends seen in the incidence of some cancers may have their origins in early life.
TREATMENT OF DYSMENORRHOEA
Authors: A. E. S. Clow
Journal: BMJ (1931)

In primate retina, “red-green” color-coding is initiated when signals originating in long (L) and middle (M) wavelength-sensitive cone photoreceptors interact antagonistically. The center-surround receptive field of “midget” ganglion cells provides the neural substrate for L versus M cone-opponent interaction, but the underlying circuitry remains unsettled, centering around the longstanding question of whether specialized cone wiring is present. To address this question, we measured the strength, sign, and spatial tuning of L and M cone input to midget receptive fields in the peripheral retina of macaque primates of either sex. Consistent with previous work, cone opponency arose when one of the cone types showed a stronger connection to the receptive field center than to the surround. We implemented a difference-of-Gaussians spatial receptive-field model, incorporating known biology of the midget circuit, to test whether the physiological responses we observed in real cells could be captured entirely by anatomical nonselectivity. When this model sampled nonselectively from a realistic cone mosaic, it accurately reproduced key features of cone-opponent receptive-field structure, and predicted both the variability and strength of cone opponency across the retina. The model introduced here is consistent with abundant anatomical evidence for nonselective wiring, explains both local and global properties of the midget population, and supports a role in their multiplexing of spatial and color information. It provides a neural basis for human chromatic sensitivity across the visual field, as well as the maintenance of normal color vision despite significant variability in the relative number of L and M cones across individuals. <b>SIGNIFICANCE STATEMENT</b> Red-green color vision is a hallmark of the human and non-human primate that starts in the retina with the presence of long (L)-- and middle (M)--wavelength sensitive cone photoreceptor types. Understanding the underlying retinal mechanism for color opponency has focused on the broad question of whether this characteristic can emerge from nonselective wiring, or whether complex cone type--specific wiring must be invoked. We provide experimental and modeling support for the hypothesis that non-selective connectivity is sufficient to produce the range of red-green color opponency observed in midget ganglion cells across the retina. Our nonselective model reproduces the diversity of physiological responses of midget cells, while also accounting for systematic changes in color sensitivity across the visual field.
Abstract 5063: Cardiovascular Effects of Transdermal Testosterone in Postmenopausal Women
Authors: C Vitale, P Collins, G Marazzi, G Caminiti, I Lodhi, C A Rodenberg, G M Rosano
Journal: Circulation (2008)

Testosterone Transdermal Patch (TTP) has been developed for the treatment of postmeno-pausal women (PMW) with hypoactive sexual desire disorder (HSDD). Since the cardiovascular (CV) effects of testosterone in women are still unclear we conducted a pooled analysis of the large phase III clinical program to evaluate the efficacy and safety of 300 μg/day TTP, alone or in association with hormone replacement therapy (HRT), versus placebo in surgical or natural PMW. Design &amp; Methods: A total of 2795 women aged between 26 –70 years (mean age 52(SD=6.8) years) were included in 5 phase III randomized, double-blind, placebo-controlled clinical trials (treatment duration range 24 – 52 weeks) as part of the TTP Clinical program. 4 studies included PMW (natural and surgical, two each respectively) receiving HRT while 1 study was conducted without HRT, in either surgical or natural PMW. Women with known CV disorders were excluded from the studies. Changes from baseline in standard metabolic and CV risk factors were compared. The incidence of stroke, myocardial infarction (MI) and venous thromboembolism (VTE) alone or as a composite CV endpoint was assessed. Results: The 2795 PMW were randomized to receive either placebo (n=1297) or TTP (n=1498). Baseline mean BMI was 27 kg/m2 (SD=5.3 kg/m2) and 56% were naturally menopausal. The demographic and baseline parameters were similar among the treatment groups. No significant changes in CV risk factors (Total Cholesterol, Triglycerides, Insulin, Glucose, Systolic and Diastolic Blood Pressure) were detected during the study period, apart from a blunting of the increases in HDL-C by TTP at 24 and 52 weeks (Placebo 52-week mean change 2.59 mg/dl vs. TTP 52-week mean change 1.20 mg/dl, p&lt;0.005) and of the decrease in LDL-C by TTP at 24 (p&lt;0.05), but not at 52 weeks. During the double-blind (24 weeks), placebo-controlled period of the combined studies, 4 major CV events (2 MIs and 2 strokes) were reported in placebo patients and 3 (2 MIs and 1 stroke) in those receiving TTP. One VTE occurred in a patient receiving TTP and HRT. Conclusion: TTP therapy in these clinical trials did not adversely affect CV risk profile and did not change the risk of major CV events in these surgical and naturally PMW with or without concomitant HRT.
Use of blood in elective surgery
Authors: D. P. Sarma
Journal: JAMA (1980)

A retrospective study of blood-ordering practices and blood use for elective surgical procedures at the Veterans Administration Medical Center of New Orleans shows a cross match-to-transfusion ratio of 4.29. To reduce this ratio, a guideline for ABO-Rh type and antibody screen (type and screen) is implemented. This avoids routine cross matching for those surgical procedures where blood is seldom transfused. (<i>JAMA</i>243:1536-1538, 1980)
Magnetic Resonance Imaging (MRI) Detection of Iron Overload In Patients with Myelodysplastic Syndrome (MDS),
Authors: Fabio P S Santos, Claudia Bley, Ricardo Helman, Guilherme Fleury Perini, Leandro de Padua Silva, Isabel Bello, Carolina Kassab, Breno Pannia Esposito, Murilo Sergio S. Ribeiro, Cesar Higa Nomura, Fernando Uliana Kay, Ronaldo Hueb Baroni, Elvira RP Velloso, Nelson Hamerschlak
Journal: Blood (2011)
Aspiration of metallic mercury. A 22-year follow-up
Authors: V. J. Dzau
Journal: JAMA (1977)

Rupture of the mercury-filled bag of an intestinal tube resulted in aspiration of metallic mercury 22 years ago in the patient reported. Immediate respiratory distress was treated with vigorous suctioning and postural drainage. Follow-up chest roentgenograms persistently showed radiopaque particles in the lungs. Signs and symptoms of chronic respiratory disease have since developed in the patient. Postmortem findings from the lungs included globules of metallic mercury surrounded by extensive fibrosis and granuloma formation, which we believe to be the result of local irritative effects of mercury. (<i>JAMA</i>238:1531-1532, 1977)
ABREAST OF THE TIMES
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antihypertensive Chlorothiazide Analogue Devoid of Diuretic Activity
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OUR MEDICAL COLLEGES.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of the Pyrogen Test in Chronic Pyelonephritis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HEPATIC TOXEMIA AS A LATE EFFECT OF CHLOROFORM.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Variation in office-based quality. A claims-based profile of care provided to Medicare patients with diabetes
Authors: J. P. Weiner
Journal: JAMA (1995)

<h3>Objectives.</h3> —To demonstrate that claims data "profiling" can be used as an on-going method to support ambulatory care quality improvement; to measure the quality of office-based care provided to elderly patients with diabetes in three states; and to identify factors associated with better attainment of quality standards. <h3>Study Design.</h3> —A cross-sectional study based on a 100% sample of the Medicare claims (Part B and Part A) submitted between July 1, 1990, and June 30,1991. <h3>Setting.</h3> —All primary care practices (both solo and group) actively seeing Medicare patients with diabetes in Alabama, Iowa, and Maryland (n=2980). <h3>Patients.</h3> —All elderly (≥65 years) Medicare patients seen by the study physicians and assigned a diagnosis of diabetes (n=97 388) by any office-based physician during the year. <h3>Main Outcome Measures.</h3> —The proportion of patients with diabetes receiving the following procedures (from any provider) at least once during the study period: hemoglobin A<sub>1C</sub>measurement, ophthalmologic examination, total cholesterol measurement, and blood glucose measurement. We considered the first three services to be optimally recommended and blood glucose measurement to be of limited use. <h3>Results.</h3> —Based on analyses of services provided in the ambulatory setting, we found that 84% of diabetics did not appear to receive the recommended hemoglobin A<sub>1C</sub>measurement, 54% did not see an ophthalmologist, and 45% received no cholesterol screening. Practice patterns varied considerably across the three states (up to 2.38-fold), even after adjusting for patient case mix and physician characteristics. Patients of general practitioners were less likely to meet recommended quality criteria than patients of internists or family practitioners. Patients receiving care from rural practitioners were less likely to receive services, either recommended or not, than those in urban locations. <h3>Conclusions.</h3> —Elderly patients with diabetes do not appear to be receiving optimal care. This study underscores the value of practice guideline development and dissemination in the ambulatory arena. This study provides substantial evidence that existing administrative claims data can be used to support ambulatory quality improvement activities. (<i>JAMA</i>. 1995;273:1503-1508)
Acute and follow-up results of percutaneous trans-mitral commissurotomy in 352 patients of Juvenile mitral stenosis Dhiraj Gupta, Vinay K. Bahl, Gautam Sharma, Shyam S Kothari, Anita Saxena, Rajnish Juneja, Kewal C Goswami, Kewal K Talwar, Subhash C Manchanda. All India Institute of Medical Sciences, New Delhi, India
Journal: Journal of the American College of Cardiology (2001)
A large mesenteric cyst complicating pregnancy
Authors: J. M. Dunn
Journal: JAMA (1967)

MESENTERIC CYSTS are rare. Since the initial description in 1507, approximately 600 cases have been reported.<sup>1,2</sup>To my knowledge, only recently has the first mesenteric cyst associated with pregnancy been recorded<sup>2</sup>; the following case is the second. <h3>Report of a Case</h3> A 22-year-old white woman (para 3 [one pair of monozygotic twins], abortions 0, gravida 4), who had a normal obstetrical history beginning with her first pregnancy at age 15, complained of amenorrhea of three months' duration and occasional episodes of colicky abdominal pain. The uterus was soft and twice normal size; there was some distention of the upper part of the abdomen but no palpable mass. After being informed of the current pregnancy, the patient tried without success to produce an abortion by taking an unidentified drug, and did not return to the prenatal clinic at the scheduled time. During the 16th week of gestation she took
Did Akhenaten Have the Antley–Bixler Syndrome?
Authors: Irwin M. Braverman
Journal: Annals of Internal Medicine (2009)

Letters15 December 2009Did Akhenaten Have the Antley–Bixler Syndrome?Irwin M. Braverman, MD and Philip A. Mackowiak, MD, MBAIrwin M. Braverman, MDFrom Yale University School of Medicine, New Haven, CT 06520-8059; and Veterans Affairs Medical Center, Baltimore, MD 21201. and Philip A. Mackowiak, MD, MBAFrom Yale University School of Medicine, New Haven, CT 06520-8059; and Veterans Affairs Medical Center, Baltimore, MD 21201.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-12-200912150-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Our analysis of Akhenaten's kindred revealed 2 abnormalities: craniosynostosis and gynecomastia. These were best explained by 2 genetic disorders: sagittal craniosynostosis and the aromatase syndrome producing excessive estrogen. The Antley–Bixler syndrome (1) was brought to our attention as a possible explanation for our findings. However, the type of cranial deformity in ABS is very different from that found in Akhenaten's kindred, and infertility was not a problem for Akhenaten. However, the gene for the aromatase syndrome regulates a portion of the P450 enzyme system, and the gene for POR deficiency also regulates a portion of the P450 enzyme ...Reference1. Flück CE, Tajima T, Pandey AV, Arlt W, Okuhara K, Verge CF, et al. Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome. Nat Genet. 2004;36:228-30. [PMID: 14758361] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Irwin M. Braverman, MD; Philip A. Mackowiak, MD, MBAAffiliations: From Yale University School of Medicine, New Haven, CT 06520-8059; and Veterans Affairs Medical Center, Baltimore, MD 21201.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAkhenaten and the Strange Physiques of Egypt's 18th Dynasty Irwin M. Braverman , Donald B. Redford , and Philip A. Mackowiak Did Akhenaten Have the Antley–Bixler Syndrome? Walter L. Miller Metrics Cited byImpact of type 2 diabetes and microvascular complications on mortality and cardiovascular outcomes in a multiethnic Asian populationIncreased Circulating Visfatin Is Associated With Progression of Kidney Disease in Non-Diabetic Hypertensive Patients 15 December 2009Volume 151, Issue 12Page: 892KeywordsConflicts of interestDNAEnzymesEstrogensGenetic diseasesGenomicsInfertilityPrevalence odds ratioSteroidogenesis ePublished: 15 December 2009 Issue Published: 15 December 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...