AB0802 PREVALENCE OF NONALCOHOLIC FATTY LIVER DISEASE IN RHEUMATOID ARTHRITIS, AXIAL SPONDYLOARTHRITIS, AND PSORIATIC ARTHRITIS.
Authors: M. Pavía Pascual, S. Pérez, L. Rodriguez, B. Ruiz Antorán, O. Rusinovich, N. de la Torre Rubio, M. Machattou, P. Navarro Palomo, J. Campos Esteban, M. Fernandez Castro, H. Godoy, C. Barbadillo Mateos, C. Merino Argumánez, M. Espinosa, B. Garcia-Magallon, J. L. Calleja Panero, J. L. Andréu Sánchez, J. Sanz
Journal: Annals of the Rheumatic Diseases (2022)

Background Non-alcoholic fatty liver disease (NAFLD), the most common cause of liver disease, has a prevalence of about 25% in the general population. It increases mortality and comorbidity in patients with immune-mediated inflammatory diseases. Objectives The main objective is to estimate the prevalence of NAFLD in three of the most common rheumatologic pathologies: rheumatoid arthritis (RA), axial spondyloarthritis (SpA-ax) and psoriatic arthritis (PsA). As a secondary objective, the possibility of finding associated risk factors in this group of subjects that may imply a higher risk of developing NAFLD is proposed. Methods We conducted a prospective single center observational study which included patients diagnosed with RA, EspA-ax, and PsA attended in the Rheumatology department of a tertiary hospital from January to April 2021. Anthropometric parameters, history related to cardiovascular risk factors and disease activity at the time of the visit were collected. Additionally, blood tests and transitional elastography were performed in all patients and the presence of NAFLD was assessed by the fatty liver index (FLI) scale. Different variables were considered to study their association with NAFLD. Results 90 patients were included: 28 diagnosed with RA, 36 with EspA-ax and 26 with PAs. 41.1% were male (age range: 27-79 years). Patients with previous liver disease were excluded from the study. 22 (27.2%) patients had NAFLD measured by FLI ≥ 60. No significant differences in prevalence of hepatic steatosis were found between the 3 groups, although values were higher in patients with PsA. The variables that were significantly associated with the development of NAFLD in our cohort were: body mass index (BMI), abdominal perimeter, blood glucose level, HOMA-IR (Homeostatic Model Assessment for Insulin Resistance), HDL, TG, GGT, ferritin and uric acid levels. The rest of the variables studied did not show statistically significant differences (Table 1). Table 1. NO STEATOSIS (FLI&lt;60)n=59 STEATOSIS (FLI&gt;60)n=22 Mean Standard deviation Mean Standard deviation p BMI 24,52 3,00 30,29 2,77 &lt; 0,001 Abdominal perimeter 86,34 10,01 106,82 8,55 &lt; 0,001 Age 52,93 12,87 57,59 8,24 0,1185 Glucose 78,64 8,37 90,64 19,69 0,0002 Insulin 8,83 10,12 12,40 6,66 0,1302 HOMA 1,75 2,02 2,76 1,70 0,0500 HbA1c 5,35 0,45 5,69 0,64 0,0096 Total cholesterol 190,98 29,46 201,41 38,53 0,1977 HDL 64,88 17,66 55,59 11,55 0,0249 LDL 110,44 28,45 120,00 36,21 0,2163 TG 81,12 32,42 128,50 55,52 &lt; 0,001 GPT 25,83 30,73 37,18 19,82 0,1116 GOT 27,20 23,49 26,82 10,69 0,9413 GGT 20,80 17,66 49,95 38,46 &lt; 0,001 Creatinin 0,75 0,19 0,84 0,18 0,0583 Uric acid 4,78 1,30 5,91 1,14 0,0007 Ferritina 121,75 111,30 208,00 140,17 0,0050 PCR 2,89 4,55 2,67 2,33 0,8307 Conclusion Hepatic steatosis was present in 27.2% of patients vs 25% estimated prevalence in the general population. Identification of risk factors involved would allow better control of the comorbidities associated with NAFLD. The fact that the prevalence found in our sample population is so close to that of the general population, may be related to a good inflammatory control of the underlying disease. Further prospective studies with larger sample sizes are needed to find additional predictive factors for the development of NAFLD in this group of diseases. References [1]Bedogni, G., Bellentani, S., Miglioli, L., Masutti, F., Passalacqua, M., Castiglione, A. y Tiribelli, C. (2006). The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population . BMC Gastroenterology , 6: 33. [2]Brenner, C., Galluzzi, L., Kepp, O. y Kroemer, G. (2013). Decoding cell death signals in liver inflammation . Journal of Hepatology , 59(3): 583-594. [3]Byrne, C.D. y Targher, G. (2015). NAFLD: a multisystem disease . Journal of Hepatology , 62(1 Suppl): 47 [4]Miele, L., Vallone, S., Cefalo, C., La Torre, G., Di Stasi, C., Vecchio, F.M., et al. (2009). Prevalence, characteristics and severity of non-alcoholic fatty liver disease in patients with chronic plaque psoriasis . Journal of Hepatology , 51(4): 778-786. Disclosure of Interests None declared