tbuckley/cabot-search huggingface dataset:
Leptin in Relation to Hypertension: The Role of Obesity in the Insulin Resistance Atherosclerosis Study (IRAS)
Authors: Sharon M Smith, Elizabeth J Mayer-Davis
Journal: Circulation (2001)

P53 Background: Leptin, a protein secreted by adipose tissue, has actions that may affect blood pressure via energy balance, insulin sensitivity and/ or the central nervous system. Purpose: The purpose of this abstract is to evaluate the association between leptin level and blood pressure in the multi-center, tri-ethnic Insulin Resistance Atherosclerosis Study (IRAS) population. Methods: IRAS participants (n=1507) were age 40-69 years; 56% female; mean body mass index (BMI)= 29 kg/m2; and 39% hypertensive. Main exposure: multi species leptin radioimmunoassay was used to quantify leptin concentrations (Linco Research Inc., St. Louis, MO; range 0-122.19ng/ml). Main outcome: Main outcome was hypertension (Yes/No), defined as a systolic &gt;=140mm Hg and/ or a diastolic reading of &gt;=90mm Hg or taking antihypertensive medication. Analysis: Logistic regression was used to analyze the relationship between leptin and hypertension, while adjusting for age, dietary fat, gender, activity, ethnicity and clinic. Final models evaluated the role of obesity. Results: The proportion of individuals that were hypertensive by quartile was 28%, 40%, 40% and 49%, respectively. The odds of being hypertensive was 1.60 (p=0.0001) times higher for every 16ng/ml (1 SD) change in leptin after adjusting for age, gender, dietary fat, ethnicity and clinic site, and energy expended (n=1507). The role of BMI (leptin*BMI) was considered, resulting in a reduction of leptin’s effect on hypertension (p=0.02 for the interaction term). The overall odds ratio for being hypertensive per 16ng/ml (1 SD) change was 1.80 (p=0.04) with an attenuation of the effect as BMI increased (estimated OR for BMI of 22, 27 and 32 was 1.23, 1.14, and 1.05 respectively). Analysis were repeated excluding those with diabetes (n=999) and results were essentially unchanged. Conclusion: Increased leptin is associated with increased occurrence of hypertension and its effect is attenuated by increasing BMI. Future work is necessary to confirm and explain these results.
Patent ductus arteriosus in a 72-year-old woman. Successful corrective surgery
Authors: T. R. Hornsten
Journal: JAMA (1967)

UNCOMPLICATED patent ductus arteriosus is usually considered to be a disease of the young. Nevertheless, several cases have been described citing the existence of this defect in elderly persons.<sup>1-5</sup>These individuals are occasionally asymptomatic.<sup>2</sup>Congestive heart failure in the elderly patient with a patent ductus arteriosus is usually treated medically, and surgical correction is withheld. Because of the rarity of surgical correction of patent ductus arteriosus in the elderly, we are reporting the following case of a 72-year-old woman with congestive heart failure successfully treated by division and suture of a patent ductus arteriosus. To our knowledge this patient is one of the oldest who has been so treated. <h3>Report of a Case</h3> A 72-year-old white woman was first seen by one of us (H.K.H.) on May 13, 1965. Her chief complaint was shortness of breath. The patient had been told at 4 years of age that she
Specialists or generalists. On whom should we base the American health care system?
Authors: R. A. Rosenblatt
Journal: JAMA (1992)

One of the enduring debates in American medical policy is whether the United States should build its medical care system on a foundation of medical generalists or rely instead on more narrowly defined specialists.<sup>1,2</sup>For the most part, we have taken the latter road.<sup>3</sup>Despite 21 years of federal programs designed to increase the production of primary care physicians, most physicians select specialty careers, a trend that has accelerated with declining match rates in primary care fields in recent years.<sup>4</sup> Although the debate has been both loud and long, the evidence available to resolve this issue rationally has been somewhat meager and frequently flawed. It is very difficult to determine exactly what physicians do, much less how much it costs or how profound its impact. Answering these questions is difficult, methodologically treacherous, and enormously expensive. Unlike a population of laboratory animals, physicians are reluctant and often fractious
Diagnosis and Management of Hereditary Hemochromatosis
Authors: L. Valberg
Journal: Annual Review of Medicine (1985)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More
Forkhead Box Protein 3 (FoxP3) Demethylation Is Associated with Tolerance Induction in Peanut-Induced Intestinal Allergy
Authors: Meiqin Wang, Ivana Yang, Elizabeth J. Davidson, Anthony Joetham, Jordan K. Abbott, Brian P. O'Connor, Erwin W. Gelfand
Journal: Journal of Allergy and Clinical Immunology (2016)
Direct-acting antivirals improve treatment outcomes in patients with chronic hepatitis C-related hepatocellular carcinoma treated with transarterial chemoembolization: a nationwide, multi-center, retrospective cohort study
Authors: Hye Kyung Hyun, Eun Ju Cho, Soo Young Park, Young Mi Hong, Soon Sun Kim, Hwi Young Kim, Nae-Yun Heo, Jung Gil Park, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Jeonghoon Lee, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon, Won Young Tak, Young Oh Kweon, Ki Tae yoon, Mong Cho, Jae Youn Cheong, Seung Ha Park, Hye Yeon Chon, Ho Soo Chun, Jae Seung Lee, Hye Won LEE, Seung Up Kim
Journal: Journal of Hepatology (2020)
Transforming growth factor β<sub>2</sub>induced pleurodesis is not inhibited by corticosteroids
Authors: Y C G Lee, C J Devin, L R Teixeira, J T Rogers, P J Thompson, K B Lane, R W Light
Journal: Thorax (2001)

BACKGROUND Talc and tetracyclines induce pleurodesis by directly injuring the pleura. The injury results in intense inflammation which subsequently leads to fibrosis. Corticosteroids can inhibit talc pleurodesis by reducing the inflammatory process. We hypothesised that transforming growth factor β 2 (TGFβ 2 ), a fibrogenic cytokine with immunomodulatory functions, could induce effective pleurodesis without generating significant pleural inflammation and therefore remain effective despite co-administration of corticosteroids. METHODS Thirty rabbits were divided into two groups. Rabbits in the steroid group received weekly intramuscular injections of triamcinolone diacetate (0.8 mg/kg). Ten rabbits in each group were given 5.0 μg TGFβ 2 intrapleurally via a chest tube while the remaining five received 1.7 μg TGFβ 2 . Pleurodesis was graded macroscopically after 14 days from 1 (none) to 8 (&gt;50% symphysis). RESULTS TGFβ 2 produced excellent pleurodesis at both 5.0 μg and 1.7 μg doses. The pleural effusions produced after the injection were low in all inflammatory markers. No significant differences were seen between the steroid group and controls in macroscopic pleurodesis scores (7.2 (1.3) v 7.1 (1.2)), levels of inflammatory markers in the pleural fluids (leucocyte 1107 (387)/mm 3 v 1376 (581)/mm 3 ; protein 3.1 (0.3) mg/dl v 2.9 (0.3) mg/dl, and LDH 478 (232) IU/l v 502 (123) IU/l), and the degree of microscopic pleural fibrosis and pleural inflammation. CONCLUSIONS TGFβ 2 can induce effective pleurodesis and remains effective in the presence of high dose parenteral corticosteroids.
HCV therapeutics
Authors: Jerzy Jaroszewicz -Speaking, Anna Parfieniuk-Kowerda, Mag- Dalena Widerska, Magdalena Rogalska-Plonska, Tadeusz Lapinski, Ke Ma, Junshuai Wang, Meifang Han, Wei Guo, Jiaquan Huang, Daofeng Yang, Xiping Zhao, Jianxin Song, Deying Tian, Junying Qi, Yuancheng Huang, Qin Ning, Marisa Montes, Mark Nelson, Marie Girard, Joe Sasadeusz, Andrzej Horban, Beatriz Grinsztejn, Natalia Zakharova, Karolin Falconer, Inge Dierynck, Donghan Luo, Yi-Wen Ma, James Witek, Mark Sulkowski, David Thomas, Ashwin Balagopal, Abraham Kandathil, Johnanathan Wood, Fuat Kurbanov, Jeffrey Quinn, Justin Richer, Yvonne Higgins, Lois Eldred, Zhiping Li
Journal: Hepatology (2013)

log10 IU/mL, P=0.003) compared to patients with normal ALT but fluctuating HBV-DNA.Conclusions.Low serum IL-10 and HBsAg seem to be associated with long-term immune control of persistent HBV.Single measurement of IL-10 and HBsAg (<1000 IU/mL) may indicate stable low replicative carrier phase.On the other hand patients with high IL-10 (>0.9 pg/mL) and normal ALT will most likely reactivate HBV replication.
Localization of alpha2-macroglobulin protein and messenger RNA in rat liver fibrosis: Evidence for the synthesis of alpha2-macroglobulin within Schistosoma mansoni egg granulomas
Authors: A Tiggelman
Journal: Hepatology (1996)

alpha2-Macroglobulin (alpha2M) in the rat is a strong-reacting acute-phase protein with potent protease-inhibiting and cytokine-binding properties. Production of alpha2M is ascribed mainly to liver parenchymal cells. In the present study, we investigated, by means of immunohistochemistry and in situ hybridization, whether fibrosis in the rat liver induced by Schistosoma mansoni eggs leads to local production of alpha2M. alpha2M protein and messenger RNA (mRNA) in the unaffected liver tissue, as well as serum values of alpha2M, were comparable in control rats and egg-injected rats, at 1, 3, and 8 weeks after injection of the eggs. alpha2M was homogeneously distributed across the liver lobule. In contrast, at the sites of the granulomas, a strong increase in alpha2M was observed. alpha2M mRNA was expressed by granuloma cells, but not by the surrounding liver parenchymal cells. Within the granulomas, alpha2M protein was present in numerous spindle-shaped cells and was diffusely distributed in the extra-cellular matrix. Using double-staining techniques, a subpopulation of the alpha2M-positive cells in the granulomas appeared to be desmin-positive, suggesting a myofibroblast origin. In addition, parenchymal cells directly surrounding the granulomas contained alpha2M protein in approximately 50% of the granulomas 1 week after injection of the eggs. In situ hybridization on consecutive sections revealed that these parenchymal cells showed only background activity of alpha2M mRNA, suggesting uptake of alpha2M-protein by these parenchymal cells and previous activation of alpha2M by proteases within the granuloma. The significance of the present study is that alpha2M is produced locally at sites of inflammation and liver fibrosis, without measurable increase of serum levels of alpha2M. Unexpectedly, alpha2M present at the sites of the granulomas is not produced by the liver parenchymal cells, but rather by granuloma cells. (Hepatology 1996 May;23(5):1260-7)
Pembrolizumab Monotherapy for NSCLC Extends Survival
Journal: Cancer Discovery (2018)

The PD-1 inhibitor pembrolizumab may be a better first-line treatment than chemotherapy for many patients with advanced non-small cell lung cancer: In a phase III trial, patients with PD-L1 expression of 1% or higher treated with the drug had better overall survival, a longer duration of response, and fewer side effects than patients who received chemotherapy alone.
Valve Calcification and Patients With Bicuspid Aortic Valves—Reply
Authors: Samuel Siu
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMA Physician's Recognition Award— A Successful Start and an Important Future
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ETIOLOGY OF MALARIA.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Food Factor in Disease. Being an Investigation Into the Humoral Causation, Meaning, Mechanism, and Rational Treatment, Preventive and Curative of the Paroxysmal Neuroses, etc., and Other Degeneration.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Consanguineous Marriage
Authors: A. W. Bourne
Journal: BMJ (1963)

MEDICBJOURNA1947, but the mass at the transverse colon was much larger than before and a biopsy only was taken, which showed the presence of anaplastic adenocarcinoma.The patient made a good recovery and was discharged home on December 20, 1947.She attended my follow-up clinic for some years and I last saw her about 10 years ago."On October 2, 1963, the patient was admitted to New Cross Hospital in a con- fused senile state associated with hyperten- sion, blood-pressure 220/130, and severe bronchopneumonia from which she died on October 7.At necropsy there was an encysted empyema between the middle and lower lobes of the right lung, the lower lobe showing bronchopneumonia.The left lung was congested.The heart weighed 430 g. and the coronary arteries were atheromatous.The gastro-intesti nal tract showed no evidence of growth.The omentum and mesentery appeared normal.No glands were present.Sections were examined from post- mortem tissues and no evidence of carcinoma was demonstrated.We are grateful for the co-operation of
American Journal of Proctology, New York
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Residues Glu2181-Val2243 Contain a Major Determinant of the Inhibitory Epitope in the C2 Domain of Human Factor VIII
Authors: John F. Healey, Rachel T. Barrow, Hiba M. Tamim, Ira M. Lubin, Midori Shima, Dorothea Scandella, Pete Lollar
Journal: Blood (1998)
Liver disease in pediatric patients with cystic fibrosis is associated with glutathione S-transferase P1 polymorphism
Authors: A Henrion-Caude
Journal: Hepatology (2002)

Liver disease in patients with cystic fibrosis (CF) is inconstant and has not yet been clearly related to any specific risk factor. While the expression of cystic fibrosis transmembrane conductance regulator (CFTR) is restricted to the biliary epithelium in the liver, recent findings indicate that CFTR modulates reduced glutathione (GSH) transport and that CFTR dysfunction creates an imbalance in the antioxidant defense. Among liver detoxifying enzymes, the glutathione S-transferases (GSTs) play a key role in the protection against oxidative stress. Because oxidative injury contributes to the development of liver disease, we hypothesized that 2 members of the GST superfamily, GSTM1 and GSTP1, which are expressed in the biliary epithelium, could influence the hepatic status in patients with CF. The potential impact of GSTM1 and GSTP1 gene polymorphisms was assessed in 106 children with CF (mean age, 11.5 years). Based on polymerase chain reaction/restriction fragment length polymorphism analysis, we found that the frequency of GSTP1-Ile105/Ile105 genotype was significantly higher in patients with CF with liver disease than in those without (P < .03). Among the youngest patients, aged 6 years, GSTP1-Ile105/Ile105 genotype was associated with a 8-fold increase in the risk of liver disease compared with other GSTP1 genotypes (P = .002). No association between the GSTM1 genotype and liver status was documented. In conclusion, GSTP1-Ile105-encoding allele contributes to hepatic dysfunction in CF. Identification of this polymorphism may have prognostic value and prompt early treatment in patients with CF with an increased risk of liver disease. (HEPATOLOGY 2002;36:913-917.)
Reliability and validity of American Medical Association's guide to ratings of permanent impairment
Authors: D. S. Gloss
Journal: JAMA (1982)

We examined the American Medical Association's<i>Guides to the Evaluation of Permanent Impairment</i>rating schedule to determine whether this guide provided a reliable and valid assessment of hand impairment. A sample of 118 patients with permanent hand impairment was assessed using the guide. In addition, each patient underwent tests of finger dexterity, hand strength, hand-eye coordination, and the rate of manipulation. The reliability, based on the correlation between the two raters, was 0.75. For the injured hand, psychomotor test scores were highly correlated with the rating of permanent impairment in all cases. These differences were statistically significant for approximately two thirds of the cases. The guide's ratings showed both substantial reliability and accuracy with the various tests of hand function. (<i>JAMA</i>1982;248:2292-2296)
July, 1978, Vol. 61, No. 1
Journal: JNCI Journal of the National Cancer Institute (1979)

July, 1978, Vol. 61, No. 1 Get access JNCI: Journal of the National Cancer Institute, Volume 62, Issue 4, April 1979, Page 1117, https://doi.org/10.1093/jnci/62.4.1117 Published: 01 April 1979
Clinical laboratory manifestations of exposure to dioxin in children. A six-year study of the effects of an environmental disaster near Seveso, Italy
Authors: P. Mocarelli
Journal: JAMA (1986)

Following a major environmental accident near Seveso, Italy, on July 10, 1976, we attempted to determine if the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) released into the atmosphere had any effect on the liver function and lipid metabolism of exposed children. From July 1976 to June 1982, we analyzed the results of more than 4500 laboratory tests (alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, alkaline phosphatase, cholesterol, and triglycerides in plasma and δ-aminolevulinic acid in urine) in a population of about 1500 children aged 6 to 10 years at the moment of the accident. The children exposed to the highest concentration of TCDD showed alterations in serum γ-glutamyltransferase and alanine aminotransferase activity compared with the control group. These differences were restricted to values inside limits set from the lower end of the normal range to slightly above it. The observed abnormalities were slight and disappeared with time. (<i>JAMA</i>1986;256:2687-2695)