tbuckley/cabot-search huggingface dataset:
Georg Büchner
Authors: Heinrich G. Brugsch
Journal: New England Journal of Medicine (1956)

ON February 19, 1837, Georg Büchner, physician, scientist, political refugee and poet, died in Zurich of typhoid fever. He was then only twenty-three years and four months old, but his remarkable poetical talent had already been recognized in his drama, Danton's Death, published in 1835, and became even more apparent when two plays, Leonce and Lena and Woyzeck, were published posthumously. His most recent biographer, Knight, states that Büchner showed "more unmistakable signs of genius than any other writer in the German language, Goethe excepted." In addition Büchner was a remarkable man who, still a medical student, was recognized as . . .
Ethnic disparities in the risk of hepatitis C virus-related diabetes in a large population-based cohort in Canada
Authors: Dahn Jeong, Stanley Wong, Mohammad Ehsanul Karim, Mawuena Binka, Zahid Butt, Younathan Abdia, Prince Adu, James Wilton, Amanda Yu, Maria Alvarez, Dr. Margo Pearce, Sofia Bartlett, Mel Krajden, Naveed Janjua
Journal: Journal of Hepatology (2020)
Environmental Epidemiologic Investigations in the Styrene-Butadiene Rubber Production Industry
Authors: Richard A. Lemen, Theodore J. Meinhardt, Michael S. Crandall, John M. Fajen, David P. Brown
Journal: Environmental Health Perspectives (1990)

A review of the literature and an update that is in progress of a previous retrospective cohort mortality study of the styrene-1,3-butadiene industry are discussed. The follow-up has now been extended from April 1, 1976, through December 31, 1981, for plant B and December 31, 1982, for plant A. The person-years at risk of death have gone from 34,187 to 43,341 in plant A and from 19,742 to 26,314 in plant B. Among the death certificates received to date, observed deaths have increased in both plants, with increases in cancers of the trachea, bronchus and lung and in lymphosarcomas, reticulosarcomas, and cancers of the overall lymphatic and hematopoietic system.
Final Proof
Authors: Daniel Bosch
Journal: Annals of Internal Medicine (2012)

Ad Libitum19 June 2012Final ProofDaniel BoschDaniel BoschFrom Cambridge, MA 02139.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-12-201206190-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Capital W whoseiron filings fallinto my sinkquestion markline breakCapital W whosetooth-colored sputumclimbs commaline breakCapital S slowrung by rungcomma down towardthe sinuous trapquestion markline breakCapital W whosespackled irishides its blackhumor with a patchquestion markstanza breakCapital W whosebowl has shrunkto the sizeof a thimblequestion markline breakCapital W whosespray splattersplaster andporcelain commaline breakCapital A andwhose fingerstremble like adowser apostrophes branchline breakCapital Wwhen heurges capital Kkronos tofuck himselfquestion markstanza breakCapital Tthat hairand this beardwere oncegolden full stopline breakCapital Tthese lipscomma partedcomma likea premonitionellipsisline breakCapital Wwomen metwith candorthis gazefull stopstanza breakthetis apostrophe... Author, Article, and Disclosure InformationAuthors: Daniel BoschAffiliations: From Cambridge, MA 02139.Current Author Address: Daniel Bosch, 154 Auburn Street, 2w, Cambridge, MA 02139. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 19 June 2012Volume 156, Issue 12 Page: 900 Keywords Falls Sputum ePublished: 19 June 2012 Issue Published: 19 June 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Surgeon-Lieutenant-Colonel Horace Parr Yeld
Authors: Arthur Helme
Journal: BMJ (1913)

a reputation among his brethren for strai htness and fearlessness of action.When the.Manchester (Central) Division was formed some twelve years ago he was appointed its first Representative in Representative Meetings, a post he held with great distinction to him- .selfand satisfaction to his brother members till his 'death.It is remarkable that year after year a Division wlhich consists largely of consultants should have renewed their confidence in a general practitioner as their Representative.When his lhealth failed two or three years ago no one would hear of his place being filled up by another, and Dr. T.
THE DISEASE OF INEBRIETY.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening for Prostate Cancer: U.S. Preventive Services Task Force Recommendation Statement
Journal: Annals of Internal Medicine (2008)

Description: Update of the 2002 U.S. Preventive Services Task Force (USPSTF) recommendation statement about screening for prostate cancer. Methods: The USPSTF evaluated randomized, controlled trials of the benefits of prostate cancer screening; cohort and cross-sectional studies of the psychological harms of false-positive prostate-specific antigen test results; and evidence on the natural history of prostate-specific antigen–detected prostate cancer to address previously identified gaps in the evidence from the 2002 USPSTF recommendation. Recommendations: Current evidence is insufficient to assess the balance of benefits and harms of screening for prostate cancer in men younger than age 75 years (I statement). Do not screen for prostate cancer in men age 75 years or older (Grade D recommendation).
Isolation and Culture of Pulmonary Endothelial Cells
Authors: Una S. Ryan
Journal: Environmental Health Perspectives (1984)

Methods for isolation, identification and culture of pulmonary endothelial cells are now routine. In the past, methods of isolation have used proteolytic enzymes to detach cells; thereafter, traditional methods for cell passaging have used trypsin/EDTA mixtures. Cells isolated and passaged using proteolytic enzymes have been useful in establishing the field and in verifying certain endothelial properties. However, there is a growing awareness of the role of endothelial cells in processing vasoactive substances, in responding to hormones and other agonists and in cell-cell interactions with other cell types of the vascular wall, with blood cells and with cellular products. Consequently, a new requirement has arisen for cells in vitro that maintain the differentiated properties of their counterparts in vivo. The deleterious effects of trypsin and other proteolytic enzymes commonly used in cell culture on surface structures of endothelial cells such as enzymes, receptors and junctional proteins, as well as on extracellular layers such as the glycocalyx or "endothelial fuzz," have led to the development of methods that avoid use of proteolytic enzymes at both the isolation step and during subsequent subculture. This chapter describes traditional methods for isolating pulmonary endothelial cells but emphasizes newer approaches using mechanical harvest and scale-up using microcarriers. The new methods allow maintenance of long-term, large-scale cultures of cells that retain the full complement of surface properties and that maintain the cobblestone monolayer morphology and differentiated functional properties. Methods for identification of isolated cells are therefore also considered as methods for validation of cultures during their in vitro lifespan.
Risankizumab 对斑块状银屑病的疗效是否优于苏金单抗?
Journal: British Journal of Dermatology (2021)

斑块状银屑病是一种常见的炎症性疾病, 会导致皮肤上出现凸起的鳞状斑块 (斑片) 。免疫系统异常可能是导致银屑病的重要原因。Risankizumab 和苏金单抗是注射到患者皮下以治疗免疫系统不同部分的生物药物。这两种药物均已在美国和欧盟获得批准, 用于治疗中度至重度斑块状银屑病。
Propranolol After Myocardial Infarction-Reply
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On improving the public health
Authors: C. D. Aring
Journal: JAMA (1978)

PERHAPS the most promising potential for improving the public health resides in what people can be motivated to do for themselves. To assist patients to become more mature requires some tempering of medical omnipotence. The process resembles somewhat the rearing of children, where their eventual maturity depends mainly on the quality of parenting. The traditional role of the physician as teacher requires nurture if it is to be expected that patients will thrive and grow. This was the course embarked on by Thomas Jefferson when he established the study of medicine at the University of Virginia, where one of the goals was that every Virginian learn the care of his own health. For Jefferson, man certainly was not defined by his illness. A free man with growth potential in all areas was considered by him bound to live as constructively as he could under any and all circumstances, including illness
J Thoracic &amp; Cardiovascular Surgery, St. Louis
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Zur Kenntnis der Hirnveränderungen bei der normalen Altersinvolution
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
&lt;TITLE&gt;Depression&lt;/TITLE&gt;
Journal: JAMA (2000)

is a public service of JAMA.The information and recommendations appearing on this page are appropriate in most instances, but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA and the AMA suggest that you consult your physician.This page may be reproduced noncommercially by physicians and other health care professionals to share with patients.Any other reproduction is subject to AMA approval.
Plasma levels of asymmetric dimethylarginine are not increased in patients with coronary artery disease and hyperhomocysteinemia Torfi F. Jonasson, Thomas Hedner, Bj�rn Hultberg, Hans �hlin. Dept. of Cardiology University Hospital, Lund, Sweden, Dept. of Clinical Pharmacology University Hospital of Sahlgren, Gothenburg, Sweden
Journal: Journal of the American College of Cardiology (2001)
From the Alcohol, Drug Abuse, and Mental Health Administration
Authors: F. K. Goodwin
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pheochromocytoma of the urinary bladder
Authors: J. E. Lathem
Journal: JAMA (1966)

TWELVE previous cases of pheochromocytoma of the urinary bladder have been reported in English medical literature to our knowledge.<sup>1-10</sup>In most instances it has been mistaken for carcinoma of the bladder and a correct preoperative diagnosis has been unusual. The mortality of surgical procedures on undiagnosed pheochromocytomas in any location may reach 45%. With proper preparation and control during surgery, the mortality may be reduced to as low as 13%.<sup>11</sup> Most pheochromocytomas of the urinary bladder present many of the signs and symptoms of more common bladder tumors (Table 1). A history of headaches, especially when associated with voiding, and either sustained or intermittent hypertension are clues which must be thoroughly and completely evaluated before the possibility of pheochromocytoma can be excluded. The present case demonstrates that the clinical characteristics assume much greater importance when the lesion is located in the bladder than when the tumor is
Abstract 1051: Dianhydrogalactitol (VAL-083) reduces glioblastoma tumor growth upon bevacizumab-induced hypoxia, <i>in vivo</i>
Authors: Anna Golebiewska, Anais Oudin, Anne Steino, Simone P. Niclou, Jeffrey Bacha, Dennis M. Brown
Journal: Cancer Research (2019)

Abstract Background: Standard-of-care for glioblastoma (GBM) includes surgery, radiation and temozolomide (TMZ). Nearly all tumors recur and 5-year survival is less than 3%. Unmethylated promoter status for O6-methylguanine-DNA-methyltransferase (MGMT) is a validated biomarker for TMZ-resistance. Second-line treatment with bevacizumab has not only failed to improve survival, but has also been shown to induce intratumor hypoxia, which is implicated in increased chemoresistance. VAL-083 is a bi-functional DNA-targeting agent that readily crosses the blood-brain barrier and accumulates in brain tumor tissue. VAL-083 induces DNA double-strand breaks at N7-guanine and cancer cell-death in GBM cancer stem cells (CSCs) and non-CSCs, independent of MGMT. We have previously shown that bevacizumab treatment upregulates expression of glucose transporters GLUT-1/GLUT-3 on GBM cells. We hypothesized that, based on its unique monosaccharide backbone structure, VAL-083 may benefit from bevacizumab-induced GLUT transporter upregulation leading to enhanced VAL-083 uptake and anti-tumor activity. Methods: To investigate the in vivo anti-tumor effect of VAL-083+bevacizumab, we used a orthotopic patient-derived xenograft GBM model. All mice carried MGMT-unmethylated, temozolomide-resistant recurrent T16 GBM tumors as detected by MRI 35 days post-implantation. Mice were grouped into control, bevacizumab, VAL-083, and VAL-083+bevacizmab. Tumor progression was measured by MRI on days 49 and 56, and tumor growth rate was calculated for the entire study (day 35 vs. 56) and for the last 7 days (day 49 vs. 56). Results: Tumors were significantly smaller in VAL-083-treated mice both compared to control (-83%, p&amp;lt;0.001) and compared to bevacizumab-treated (-75%, p&amp;lt;0.001) mice. Additionally, analysis of tumor growth in-time showed significantly reduced tumor growth rate for VAL-083+bevacizumab compared to VAL-083 alone (p&amp;lt;0.01). Conclusions: These results show strong in vivo anti-tumor efficacy of VAL-083 against MGMT-unmethylated, TMZ-resistant recurrent GBM. This effect was further augmented in combination with bevacizumab, providing rationale of clinical investigation of VAL-083 in combination with bevacizumab in the treatment of GBM. Citation Format: Anna Golebiewska, Anais Oudin, Anne Steino, Simone P. Niclou, Jeffrey Bacha, Dennis M. Brown. Dianhydrogalactitol (VAL-083) reduces glioblastoma tumor growth upon bevacizumab-induced hypoxia, in vivo [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1051.
A MODEL HEALTH PUBLICATION.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Whole-Body Circulatory Autoregulation and Hypertension
Authors: THOMAS G. COLEMAN, HARRIS J. GRANGER, ARTHUR C. GUYTON
Journal: Circulation Research (1971)

A possible cause of elevated arterial pressure involves the interrelationship between autoregulation of blood flow and control of arterial blood pressure. An autoregulatory response could theoretically result in an elevated arterial pressure and an elevated peripheral resistance with normal or nearly normal cardiac output. Several experimental studies support this theory. Autoregulation of blood flow has been observed in a number of the body's tissues, and the summated effect, whole-body autoregulation, has been demonstrated in areflex dogs. An increase in cardiac output precedes an increase in total peripheral resistance, and a decrease in cardiac output precedes a decrease in total peripheral resistance. The gain of the system was calculated to be slightly greater than three. This same hemodynamic pattern, that is, an increase in cardiac output preceding an increase in resistance, has been observed at the onset of hypertension. We have observed increases in cardiac output at the beginning of salt-induced hypertension in dogs and at the beginning of hypertension secondary to fluid volume expansion in anephric patients, while other investigators have observed this hemodynamic pattern in a number of instances, including labile hypertension, perinephritis hypertension, and Goldblatt hypertension. The increased cardiac output can be caused by several factors, although in many instances the cause appears to be fluid retention. A hemodynamic response suggesting the involvement of whole-body autoregulation, that is, a decrease in cardiac output precedes a decrease in peripheral resistance, has been observed in the reversal of hypertension. Dehydrating overhydrated (and hypertensive) anephric patients and unclipping the renal artery in Goldblatt hypertension elicits this pattern, as well as administration of diuretics or several other antihypertensive drugs to hypertensives. Theoretically, the role of the kidney in hypertension is either to initiate the autoregulatory response by causing fluid retention or to allow the autoregulatory response to occur by preventing the loss of fluid in the face of an elevated arterial pressure.
Domiciliary consultations
Authors: A J H. Al-Barazanchi
Journal: BMJ (1988)

Domiciliary consultationsAs the domiciliary consultation service is specifically for patients who are unfit to attend hospital it is hardly surprising that Drs John Fry and Gerald Sandler found the highest rates of consultation in geriatric medicine (30 July, p 337).Some geriatric units have, however, abandoned domiciliary visits altogether, regarding them as a barrier to ad-
A Novel Epstein-Barr Virus-Like Virus, HVMNE, in aMacaca Nemestrina With Mycosis Fungoides
Authors: E.D. Rivadeneira, M.G. Ferrari, R.F. Jarrett, A.A. Armstrong, P. Markham, T. Birkebak, S. Takemoto, C. Johnson-Delaney, J. Pecon-Slattery, E.A. Clark, G. Franchini
Journal: Blood (1999)