tbuckley/cabot-search huggingface dataset:
Phenolsulfonphthalein (PSP) in assessment of renal function
Authors: M. H. Gault
Journal: JAMA (1967)

Since the first report<sup>1</sup>of the rapid excretion of phenolsulfonphthalein (PSP) or phenol red by the kidney, PSP has been used widely to assess renal function, without serious mishap.<sup>2</sup>Use of the intravenous route and earlier measurement of excretion (starting at 15 minutes) have enhanced the value of the test. The mechanism of tubular excretion of PSP has been reviewed.<sup>3</sup>Its maximal excretory rate in man is about 36 mg/min/1.73 sq m; 50% to 60% is extracted by the kidney in one circulation, and clearance averages 400 ml/min.<sup>4</sup>Glomerular filtration is small compared with the amount secreted by active tubular transport. Ordinarily about 2% to 3% is excreted into the bile and limited intestinal absorption occurs.<sup>5</sup>Binding to albumin in vivo appears much less than the 80% suggested by studies in vitro, and some PSP appears to enter cells other than kidney, liver, and intestine.
CONSANGUINEOUS MARRIAGES.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Erratum: </i>Vol. 67, No. 30
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

The first paragraph of text under Immunization Activities on page 833 beginning with the third sentence originally read "Administrative OPV3 coverage (calculated by dividing the number of doses administered by the estimated target population) in 2017 ranged from 100% in the central provinces of Kapitsa and Panjsher to 24% and 9% in the southern provinces of Helmand and Kabul, respectively.The proportion of children aged 6-23 months nationally with NPAFP who never received OPV through routine immunization services or SIAs (i.e., "zero-dose" children) was approximately 1% during 2016-2017.High proportions of zero-dose children were reported in 2017 in Kabul (9%) and Kandahar (4%) provinces in the southern region, Kunar (8%) province in the eastern region, and Paktika (7%) province in the southeastern region."The sentences should have read "Administrative OPV3 coverage (calculated by dividing the number of doses administered by the estimated target population) in 2017 ranged from 100% in the central provinces of Kapisa and Panjsher to 24% and 9% in the southern provinces of Helmand and Zabul, respectively.The proportion of children aged 6-23 months nationally with NPAFP who never received OPV through routine immunization services or SIAs (i.e., "zero-dose" children) was approximately 1% during 2016-2017.High proportions of zero-dose children were reported in 2017 in Zabul (9%) and Kandahar (4%) provinces in the southern region, Kunar (8%) province in the eastern region, and Paktika (7%) province in the southeastern region."
Polarity within beneficence. Additional thoughts on nonaggressive obstetric management
Authors: F. R. Abrams
Journal: JAMA (1989)

CHERVENAK and McCullough<sup>1</sup>continue carefully to climb the slippery slope, searching for secure stopping places between the poles. At one extreme are the evolving-world moral relativists, rallied 'round the flag of quality of life. They are inclined to be consequentialists, concerned with reasonably predictable results of action in the here and now. At the other end are the fixed-world moral absolutists, bearing the banner of sanctity of life. They are inclined to be deontologists, concerned with axioms based on values often but not always established by faith. By one group Chervenak and McCullough will be commended for endorsing a reasoned use of available technology to prognosticate and thereby select the<i>statistically</i>appropriate treatment for a fetus-patient. This technique involves a palatable mixture of high-tech sonography and genetics seasoned with high-touch ethics, including a dollop of autonomy and a dash of beneficence. By the other group
To Whom Thanks are Due.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ERYTHEMA SCARLATINOIDES
Authors: Leon J. Menville
Journal: JAMA (1913)

I wish to report an interesting ease of erythema scarlatinoides. Mary C., aged 10, when 3 months old, was noticed by her mother to have a red rash covering the whole body, except the face, the tongue also being red. In a day or two there was a general desquamation with itching. A diagnosis of scarlet fever was made. The patient has had a yearly recurrence of the condition, which shows itself in the latter part of the spring. I saw the patient for the first time in June, 1913. She was fairly developed and nourished. The heart, lungs and abdomen showed nothing abnormal. The liver was palpable 2 cm. below the costal border in the nipple line. The spleen was not palpable. The tongue was red, but the throat normal. She had a fever with a temperature of 100 F., with head-ache and a chilly feeling. Urine: specific gravity
Diagnosis of herpes simplex encephalitis
Authors: T. A. Parrino
Journal: JAMA (1982)

<h3>In Reply.—</h3> We thank Dr Jick for providing additional information about the criteria for patient selection in the cited studies. These important details were unfortunately omitted from the published methods. We agree that the fundamental principle is to apply the same exclusion criteria equally to both cases and control subjects. We did not assert that all persons with predictably high or low rates of exposure must be included in the study groups, but simply advised that such patients not be<i>unequally</i>excluded from either the case or control group. Equal exclusion of such patients from both groups is one acceptable alternative, but whether such equality was achieved in the cited studies remains uncertain. In the first study,<sup>1</sup>for example, a woman with a recent diagnosis of breast cancer and chronic cardiovascular disease could be included in the case group, whereas a woman hospitalized for abdominal pain would be excluded
Abstract 19710: Comparison of Clinical Outcomes With the Utilization of Monitored vs. General Anesthesia in Patients Undergoing Transcatheter Aortic Valve Replacement
Authors: Sarkis Kiramijyan, Itsik Ben-Dor, Edward Koifman, Marco A Magalhaes, Romain Didier, Ricardo O Escarcega, Nevin C Baker, Smita I Negi, Won Yu Kang, Michael J Lipinski, Sa'ar Minha, Jiaxiang Gai, Rebecca Torguson, Petros Okubagzi, Lowell F Satler, Augusto D Pichard, Ron Waksman
Journal: Circulation (2015)

Introduction: There is no clear consensus in regard to the optimal anesthesia utilization in TAVR. The objective of this study was to contribute to the observational literature in evaluating the impact of monitored anesthesia care (MAC) vs. General Anesthesia (GA) in TAVR. Hypothesis: No difference in short- or long-term mortality in patients undergoing TAVR with MAC vs. GA. Methods: All consecutive patients who underwent transfemoral TAVR from May 2007 through March 2015 at the MedStar Washington Hospital Center had prospectively collected data and were retrospectively analyzed for this study. Furthermore, the cohort was dichotomized into two groups: TAVR under MAC vs. GA as planned method of anesthesia. The primary endpoints included 30-days and 1-year mortality outcomes. The secondary endpoints included: all in-hospital VARC-2 safety outcomes, mean post-procedural hospital and ICU stays, and reasons and rates for intra-procedural conversion of MAC to GA. Results: A total of N=533 consecutive patients (51% male, mean-age 83 years) who underwent TAVR under MAC (n=467) vs. GA (n=66) were evaluated. Significant baseline, procedural and in-hospital outcomes are depicted in the figure. 12% of the MAC patients required conversion to general anesthesia (figure). The MAC group had shorter post-procedural hospital (6 vs. 7.9, p=0.023) and similar ICU (2.4 vs. 2.8, p=0.355) length of stays in days vs. the GA group, respectively. The 30-days and 1-year mortality outcomes were similar between the two groups (figure). Conclusions: TAVR under controlled monitored anesthesia is feasible and safe, and can be performed in the majority of cases, therefore avoiding the need for general anesthesia and resulting in shorter post-procedural hospital stays. Most common cause for conversion of MAC to GA is cardiac instability and hypotension. TAVR procedures should be planned with MAC as the default strategy for anesthesia.
Liability Limits Rejected
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inhibition of Gap Junctional Intercellular Communication in Normal Human Breast Epithelial Cells after Treatment with Pesticides, PCBs, and PBBs, Alone or in Mixtures
Authors: Kyung-Sun Kang, Melinda R. Wilson, Tomonori Hayashi, Chia-Cheng Chang, James E. Trosko
Journal: Environmental Health Perspectives (1996)
Laetrile-induced agranulocytosis
Authors: K. B. Liegner
Journal: JAMA (1981)

PROPONENTS of laetrile claim it is beneficial and safe. Opponents point to the lack of proof of its efficacy, the delay in seeking more effective therapy its use may entail, and the risk of death or illness from cyanide poisoning resulting from its use. We report the case of a patient in whom agranulocytosis developed, apparently due to laetrile. <h3>Report of a Case</h3> On May 10, 1980, a 61-year-old woman who had been treating herself with laetrile for five years was admitted to Greenwich (Conn) Hospital because of sudden onset of rigors with fever (temperature to 39.4 °C). She had had a simple right mastectomy with axillary lymph node dissection for infiltrating ductal carcinoma in 1966. In 1975 a second primary developed and she underwent a left modified radical mastectomy, followed by a course of fluorouracil. She received five doses of 500 mg intravenously during June and July 1975, but
New York Statute of Limitations Amended.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics
Authors: Meyling Cheok, Wenjian Yang, Gianluigi Zaza, Qing Cheng, John C. Panetta, Ching-Hon Pui, James R. Downing, Mary V. Relling, William E. Evans
Journal: Journal of Clinical Investigation (2005)
Prognostic importance of premature beats following myocardial infarction. Experience in the coronary drug project
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Can we afford screening for neural tube defects?
Authors: G Jacob
Journal: BMJ (1985)

ments committees, grant awarding bodies, etc, are more impressed by the quantity than by the quality of published work.Unfortunately, the medical profession can- not seek guidance in proper behaviour from the scientific community, whose morals are questioned because of duplication and fraud.2Among so called pure scientists the ethic of "publish or perish" seems even more revered.Only when it is agreed that scientific communications are intended to further knowledge, rather than careers or egos, will we reach the peak of the present, senseless, exponential
Errors in Figure Labels
Journal: JAMA Internal Medicine (2015)

Population in the United States," published online May 26, 2015, in JAMA Internal Medicine, 1 there was an error in the Figure .The arrow from the box "Rarely, most times, or sometimes" was incorrectly placed.Also, in the first paragraph of the Discussion section, the third sentence should have read "The homebound population included approximately 400 000 people who were completely homebound and approximately 1.6 million people who rarely went out."This article was corrected online.
Update: Cholera—Western Hemisphere, 1992
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tricyclic antidepressants. Prolonged plasma levels after overdose
Authors: D. G. Spiker
Journal: JAMA (1976)

Twenty-four patients hospitalized for overdose of a tricyclic antidepressant were monitored clinically, and serial plasma-drug measurements were taken for up to 144 hours. Six of 24 patients had maximum antidepressant plasma levels ≥ 1,000 ng/ml, and their plasma levels at 96 hours ranged from 170 to 1,280 ng/ml. Patients ingesting substantial tricyclic overdoses may remain medically unstable for days. When high tricyclic levels persist, accurate psychiatric assessment is often impossible. (<i>JAMA</i>236:1711-1712, 1976)
A randomized trial comparing colchicine and ursodeoxycholic acid combination to ursodeoxycholic acid in primary biliary cirrhosis
Authors: R Poupon
Journal: Hepatology (1996)

The efficacy of colchicine combined with ursodeoxycholic acid (UDCA) and UDCA alone in the treatment of patients with nonadvanced primary biliary cirrhosis (PBC) was evaluated in a 2-year controlled study. Seventy-four patients with PBC who had been treated previously with UDCA (at least 8 months) but still had abnormal liver test results, especially elevated alkaline phosphatase activity, were randomized to be administered colchicine (1 mg/d, 5 days per week) (n = 37) or a placebo (n = 37). In addition, the patients were treated with UDCA (13-15 mg · kg-1 · day-1). The patients underwent clinical examination and liver tests every 6 months and upper endoscopy and liver biopsy at entry and at 2 years. Procollagen type III aminoterminal peptide (PIIINP), hyaluronic acid, and sulfobromophthalein (BSP) elimination kinetics were determined at entry and after 2 years. After 2 years of treatment, relative to UDCA, colchicine combined with UDCA did not significantly improve symptoms, laboratory findings (serum bilirubin level, alkaline phosphatase and alanine transaminase [ALT] activities, immunoglobulin [Ig] M level), serum markers of fibrosis, or histological features, except lobular inflammation. Colchicine did tend to slightly reduce the progression of esophageal varices; however, the difference was not significant. BSP elimination kinetics (45-minute retention percentage) was significantly improved when treated with colchicine. During the 2-year study, the only clinical complications were variceal bleeding in one patient administered colchicine and two administered the placebo. Two patients died from nonliver causes. One severe adverse effect (peripheral neuromyopathy) was observed in a colchicine-treated patient. In conclusion, this study suggests that colchicine appears to provide a slight advantage relative to UDCA alone in patients with nonadvanced PBC.
Handbook of Diseases of the Nose, Throat and Ear for Students and Practitioners.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sensitivity, specificity, and predictive value of body surface cultures in a neonatal intensive care unit
Authors: M. E. Evans
Journal: JAMA (1988)

We analyzed 24 584 cultures obtained from 3371 infants during a three-year period to determine how frequently body surface culture isolates matched those obtained subsequently from body fluids. The sensitivity, specificity, and predictive values of surface cultures were calculated daily for the two weeks up to and including the day that a body fluid culture was obtained. Isolates from cultures of material from the ear canal, nasopharynx, axilla, umbilicus, groin, rectum, stomach, and endotracheal tube were rarely the same as those recovered from blood or fluids of the cerebrospinal, joint, pleural, pericardial, and peritoneal spaces. With a frequency of sepsis of 3.3% among patients in our neonatal intensive care unit, the optimum sensitivity, specificity, and positive predictive values of surface cultures were 56%, 82%, and 7.5%, respectively. These values did not improve substantially for any specific times of surface cultures prior to sepsis, for anatomic sites cultured, or for pathogens recovered. We conclude that surface cultures are of limited value in predicting the etiology of sepsis in neonates. (<i>JAMA</i>1988;259:248-252)