tbuckley/cabot-search huggingface dataset:
Clinicopathological Cases
Journal: British Journal of Dermatology (2012)

British Journal of DermatologyVolume 167, Issue s1 p. 13-20 Free Access Clinicopathological Cases First published: 03 July 2012 https://doi.org/10.1111/j.1365-2133.2012.10937.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume167, Issues1Special Issue: Abstracts for the British Association of Dermatologists 92nd Annual Meeting. Birmingham, U.K. 3-5 July 2012.July 2012Pages 13-20 RelatedInformation
OP11 Are simple non-invasive scoring systems for fibrosis reliable in patients with NAFLD and normal ALT levels?
Authors: S. McPherson, Q. Anstee, E. Henderson, A. Burt, C. Day
Journal: Gut (2011)

<h3>Introduction</h3> With a quarter of the UK population estimated to have some degree of NAFLD, there is a need for a robust and economical population based screen to identify individuals with advanced fibrosis. It is recognised that many patients with NAFLD have normal-range ALT levels. Non-invasive scoring systems may exclude advanced disease without the need for liver biopsy, however reliability of these tests in this population has not been determined. <h3>Aim</h3> To assess performance of several simple non-invasive tests for fibrosis in patients with biopsy-proven NAFLD and normal ALT levels. <h3>Method</h3> Patients who were reviewed in the Freeman Hospital fatty liver clinic between 1999 and 2009 were included. Liver biopsies were assessed using the Kleiner score. The AST/ALT ratio, BARD, FIB-4 and NAFLD fibrosis scores were calculated from blood tests taken within 6 months of liver biopsy. <h3>Results</h3> 305 patients were included (70 with normal ALT [ALT &lt;30 IU/l for females and ALT &lt;45 IU/l for males] and 235 with raised ALT). 24% of subjects with normal ALT and 17% with raised ALT had advanced fibrosis (Kleiner stage 3–4). Patients with normal ALT were significantly younger (p=0.004) and had lower BMI (p=0.03) than those with raised ALT. The area under ROC curve (AUROC), sensitivity, specificity, positive and negative predictive values for a diagnosis of advanced fibrosis using each score is shown in Abstract OP11 table 1. In addition, the proportion of patients with a score below the cut-off who would avoid liver biopsy is displayed. The specificity of the AST/ALT ratio, BARD and NAFLD fibrosis scores for advanced fibrosis was low in patients with normal ALT, which would result in a high proportion of patients with mild disease having a liver biopsy. FIB-4 score performed best overall. <h3>Conclusion</h3> The FIB-4 score performed well in patients with normal or raised ALT, reliably excluding advanced fibrosis and reducing the need for liver biopsy. Therefore, the FIB-4 score may be an appropriate tool for use in primary care to triage patients with NAFLD who need referral for further assessment. Further validation in a general practice cohort is underway.
Magnetic Microcapsule Exploration in the Gastrointestinal Cavity of the Origins of Colorectal Cancer-Associated DNA-Damaging Agents in the Human Diet
Authors: Ian O'Neill, Sheila Bingham, Anne Ellul, Brigitte Incaurgarat
Journal: Environmental Health Perspectives (1993)

Magnetically recoverable, semipermieable mirocapsules have been devised forcovalent entrapment ofreactive substances in the intestinal cavity to biomonitor potentially DNA-damagingagents and the effects ofetiologically important components ofthe human diet.These miarocapsules have been shown to trap fivetypes ofagents in wvo, nanely, carcinogen electrophiles, nitrosating agents, mutagens/carcinogens having a planar molecular structure, and as-yet unidentified endogenous cross- linking agents and precursors of reactive osygen species.Substantial alterations in both total metabolites and types of metabolites trapped from [14Cjbenzo(a)pyrene were found to be caused by increasing (within the human intake range) the dietary levels of beef protein and dietary fiber.The system thus responds to a variety of potentially critical agents and in a manner consistent with epidemiologically important dietary modulators for colorectal carcinogenesis.Wrk toward recognizing entrapped endogenous agents has also begun.
Risk stratification and the effects of early tips among patients with Child-Pugh B cirrhosis and acute variceal bleeding
Authors: Yong Lv, Zhengyu Wang, Kai Li, Wei Bai, Chuangye He, Xulong Yuan, Tainlei Yu, Jing Niu, Luo Zuo, Zhiping Yan, Xuan Zhu, Jianbo Zhao, Hui Xue, Zaibo Jiang, Yuzheng Zhuge, Chunqing Zhang, Junhui Sun, Pengxu Ding, Weixin Ren, Yingchun Li, Kewei Zhang, Wengang Guo, Qiuhe Wang, Bohan Luo, Xiaomei Li, Na Han, Ying Zhu, Zhanxin Yin, Daiming Fan, Guohong Han
Journal: Journal of Hepatology (2020)
Osteogenic sarcoma. Prognosis related to epiphyseal closure
Authors: J. S. Nosanchuk
Journal: JAMA (1969)

Eighty-five patients with osteogenic sarcoma were treated at the University of Michigan Medical Center between 1933 and 1963. Of these, eight women and five men survived five or more years. Significantly more women survived than men, and no male less than 24 years of age survived four years. When survival data were analyzed in terms of epiphyseal closure in the involved bone, no male with a lesion adjacent to an open epiphysis survived four years, whereas four females with similar lesions survived from 5 to 34 years. Survival was not influenced by site of lesion, tumor size, delay in diagnosis or treatment, or histologic type of tumor.
Medicine keeps pace as military moves from 'Garrison' to 'expeditionary'
Authors: P. Gunby
Journal: JAMA (1991)

MILITARY PHYSICIANS from now on may be serving in a US Air Force, Army, or Navy/Marine Corps that is more "expeditionary" than "garrison." As was demonstrated dramatically during the Desert Storm and Just Cause (Panama, 1989) operations, the US military probably no longer needs to keep large forces permanently in place overseas because it can deploy "fast and far" to trouble spots where its presence is deemed to be necessary. Still, US military physicians will have many of the same duties—caring for the troops, their families, and (in some way) for at least some military retirees. And, as a result of Desert Storm, this mix of full-time and reserve military physicians is the most experienced (in terms of combat deployment) in the nation's history. (A physician who in the late 1960s and early 1970s, while serving in the Nixon and Ford administrations, played an important role in developing this "total
Cocaine deaths reported for century or more
Authors: T. Randall
Journal: JAMA (1992)

THE COCAINE craze that swung through Europe and the United States during the turn of the century has come full circle in recent decades. It is uglier and deadlier this time around. Yet to those who study medical history, it is strangely familiar, a repetition of the past that holds few surprises. "We are seeing today a lot of problems that were seen 100 years ago. Medical, political, and social, they are repeating," says Steven Karch, MD, research director of the Trauma Center at the University Medical Center of Southern Nevada, Las Vegas. Karch, a cardiac researcher, became interested in cocaine cardiotoxicity because it appears to be mediated by the same hormonal mechanisms involved in severe stress and resuscitation. He has also written on the history of cocaine toxicity (<i>Hum Pathol</i>. 1989;20:1037-1039), and last December spoke at the Third National Conference on Death and Injury Investigation in Wichita, Kan. "Contrary
Missing Names of Co–Senior Authors
Authors: Vinay Prasad
Journal: JAMA Oncology (2018)

Janet E. Murphy, MD, MPH; Jennifer Y. Wo, MD; David P. Ryan, MD; Wenqing Jiang, MS; Beow Y. Yeap, ScD; Lorraine C. Drapek, NP, PhD; Lawrence S. Blaszkowsky, MD; Eunice L. Kwak, MD, PhD; Jill N. Allen, MD; Jeffrey W. Clark, MD; Jason E. Faris, MD; Andrew X. Zhu, MD, PhD; Lipika Goyal, MD, MPhil; Keith D. Lillemoe, MD; Thomas F. DeLaney, MD; Carlos Fernández-del Castillo, MD; Cristina R. Ferrone, MD; Theodore S. Hong, MD
Obituaries
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Umbilical Vessel Angiocardiography in the Newborn
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Postpartum Thyroiditis and Autoimmune Thyroiditis in Women of Childbearing Age: Recent Insights and Consequences for Antenatal and Postnatal Care
Authors: A. F. Muller
Journal: Endocrine Reviews (2001)

Postpartum thyroiditis is a syndrome of transient or permanent thyroid dysfunction occurring in the first year after delivery and based on an autoimmune inflammation of the thyroid. The prevalence ranges from 5–7%. We discuss the role of antibodies (especially thyroid peroxidase antibodies), complement, activated T cells, and apoptosis in the outbreak of postpartum thyroiditis. Postpartum thyroiditis is conceptualized as an acute phase of autoimmune thyroid destruction in the context of an existing and ongoing process of thyroid autosensitization. From pregnancy an enhanced state of immune tolerance ensues. A rebound reaction to this pregnancy-associated immune suppression after delivery explains the aggravation of autoimmune syndromes in the puerperal period, e.g., the occurrence of clinically overt postpartum thyroiditis. Low thyroid reserve due to autoimmune thyroiditis is increasingly recognized as a serious health problem. 1) Thyroid autoimmunity increases the probability of spontaneous fetal loss. 2) Thyroid failure due to autoimmune thyroiditis—often mild and subclinical—can lead to permanent and significant impairment in neuropsychological performance of the offspring. 3) Evidence is emerging that as women age subclinical hypothyroidism—as a sequel of postpartum thyroiditis—predisposes them to cardiovascular disease. Hence, postpartum thyroiditis is no longer considered a mild and transient disorder. Screening is considered.
Granulocyte-macrophage colony-stimulating factor/interleukin-3 fusion protein (pIXY 321) enhances high-dose Ara-C-induced programmed cell death or apoptosis in human myeloid leukemia cells
Authors: K Bhalla, C Tang, AM Ibrado, S Grant, E Tourkina, C Holladay, M Hughes, ME Mahoney, Y Huang
Journal: Blood (1992)
Screening and prevention of nutritional anemia during infancy. A prospective study of food fortification
Authors: R. B. Berg
Journal: JAMA (1978)

No important differences in hemoglobin and hematocrit values occurred among subgroups of a cohort of 295 healthy, mature infants who were fed various dietary regimens of iron-fortified products, including cereal, whole milk, and corn syrup. Among all infants between the ages of 4 and 27 months, the incidence of hematocrit readings and hemoglobin levels below 30% and 10 g/dl, respectively, was 0.6%, and below 33% and 11 g/dl, respectively, was 3.2%. Because of the low incidence of nutritional anemia after age 4 months, initial screening should be done at 1 to 4 months of age, and selectively thereafter. A formula of evaporated milk and corn syrup plus iron-fortified cereal during early months, then whole milk and a more diversified diet including continued use of iron-fortified cereal during later months of infancy, provides a nutritionally sound and economical diet with sufficient iron. (<i>JAMA</i>240:1362-1365, 1978)
Contemporary Neurology
Authors: William H. Olson
Journal: JAMA (1985)

This 641-page book has 60 contributors, almost all of whom have posts in Great Britain. The first 122 pages are symptom-oriented chapters with headings such as "Headache," "Dizziness," "Facial Pain," "Coma," and "Loss of Memory." The remaining chapters are grouped under the titles "Management of Epilepsy," "Involuntary Movements," "Nerve and Muscle," "Multiple Sclerosis," "Infections," "Cerebrovascular Disease," "Trauma," "Intracranial Pressure," "Vertebral Column," and "Procedures." Each chapter is followed by a group of references, and each chapter has one or more tables, which serve for emphasis of the printed material and quick reference. The black-and-white illustrations are either photographs or simple drawings. As is usual in many books with multiple authors, the quality of the individual chapters varies. Many of the newer developments in neurology, such as intracranial-pressure monitoring, vascular surgery for the stroke syndrome, and the use of serum blood levels in the management of epilepsy, are discussed. Neurosurgical procedures for
The use and implications of do not resuscitate orders in intensive care units
Authors: J. E. Zimmerman
Journal: JAMA (1986)

To describe current "do not resuscitate" (DNR) order writing practices, we studied 7,265 intensive care unit (ICU) admissions at 13 hospitals. All of the ICUs used DNR orders and 39% of all in-unit deaths were preceded by them. Patients with DNR orders were often elderly and in severely failing health. They were more severely ill than other patients in ICUs, and often had multiple organ failure. Most patients with DNR orders (94%) died in the hospital, and 86% died or were discharged from the ICU three days after a DNR order. The frequency of DNR orders ranged from 0.4% to 13.5%, and the mean interval from ICU admission to DNR order was from 5.4 to 24 days. These variations could not be explained by differences in patient characteristics, and may reflect varying physician attitudes. Do not resuscitate orders are now an accepted practice in ICUs and their use follows basic ethical and scientific guidelines. The brief interval between writing a DNR order and death or ICU discharge suggests that they often represent a decision point for placing broader limits on therapy. (<i>JAMA</i>1986;255:351-356)
What Do Women Want? Comfy Shoes—Sometimes
Authors: S. W. Balkin
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Dr Paulshock's<sup>1</sup>review of Howard Levy's book on Chinese footbinding ends with, "Chinese women of all social classes have liberated feet." Although freed from footbinding, women's feet have not been liberated from fashion shoes that cause widespread deformity. Two hundred years ago, the Dutch physician Petrus Camper (1722-1789), in discussing the absurdities of shoe fashion, wrote, "We bestow reasonable compassion upon the fate of Chinese women who dislocate their feet in obedience to the dictates of a barbarous custom, and yet we ourselves have submitted complacently for ages to torture no less cruel."<sup>2</sup>Today it still applies as women electively damage their feet with ill-fitting and ill-designed shoes. In age groups over 65 years, women outnumber men in chronic foot disorders, with double the number of ingrown toenails, 3.5 times as many corns and calluses, and 13 times more bunions.<sup>3</sup>Women's fashion shoes induce
Ankylosing Spondylitis
Authors: John J. Calabro, Bertram A. Maltz
Journal: New England Journal of Medicine (1970)

CONSIDERABLE progress in early diagnosis and treatment of ankylosing spondylitis (Marie—Strümpell disease) comes from the recent acceptance and classification1 of this systemic disease as an entity apart from rheumatoid arthritis. Major clinical differences2 3 4 5 are listed in Table 1.As yet, etiologic studies have contributed little to the understanding of ankylosing spondylitis.6 Heredity, trauma, psychologic stress and nonspecific urogenital infections have all been suggested as possible causes. The frequent association between ankylosing spondylitis and ulcerative colitis,7 , 8 regional enteritis9 and psoriasis10 remains unexplained, as does the occasional link to Reiter's syndrome11 and juvenile rheumatoid arthritis.12 , 13 Natural HistoryEarly Disease and Modes of Onset . . .
Incidence of Air Pollution Bronchitis in Military Personnel in Japan
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical utility of hepatitis B surface antigen quantitation in patients with chronic hepatitis B: A review
Authors: Yun-Fan Liaw
Journal: Hepatology (2011)

This clinically relevant review focuses on recent findings concerning hepatitis B surface antigen (HBsAg) quantitation in untreated patients and treated patients with chronic hepatitis B. Recent studies and emerging data have shown that both HBsAg and hepatitis B virus (HBV) DNA levels decline during the natural course of a chronic HBV infection; they are lowest in the inactive phase, which is also characterized by the highest HBsAg/HBV DNA ratio. It has been demonstrated that the combined use of HBsAg and HBV DNA levels might help in the identification of true inactive carriers with high accuracy. Retrospective analyses of HBsAg levels in patients undergoing therapy have suggested a role for HBsAg quantitation in monitoring the response to therapy. In comparison with nucleos(t)ide analogues (NAs), interferon-based therapy results in greater overall declines in serum HBsAg levels. A rapid on-treatment decline in HBsAg levels appears to be predictive of a sustained response. With the aid of HBsAg quantitation, it appears that we can anticipate an individualized approach to tailoring the treatment duration. The proposal of early stopping rules for patients not responding to pegylated interferon (according to a lack of any HBsAg decline) represents a step toward a response-guided approach. The development of stopping rules for patients treated with NAs is desirable for reducing the need for lifelong therapy. However, before stopping rules for antiviral therapy can be applied, we need to learn more about the kinetics of HBsAg declines during the natural history of the infection and as a response to therapy so that we can better define the best timing, the relevant HBsAg cutoff levels, and the best ways to apply these rules in clinical practice. (HEPATOLOGY 2011;)
Strength enough
Authors: Fred Charatan
Journal: BMJ (2005)

Where appropriate we adjusted for personal characteristics and events at the time of injury.The small number of neck injuries, however, precluded control for more than a few covariates.As 13 of the participants with neck injuries who required evacuation by ambulance were in discordant matched sets, we did not consider further adjustment beyond that provided by the matching.Recall on the day of injury of a participant with head injuries was confined to a specific event for the case crossover analysis, 7 whereas recall on the previous outing may have been less accurate.If cases had over-reported previous helmet use then the protective effect of helmets would have been overestimated, but we found a consistent helmet effect between the matched case-control and case crossover analyses. Comparison with previous researchTo our knowledge only one other case-control study has been carried out to determine whether helmets protect skiers and snowboarders against head injuries. 3Those investigators evaluated combined head, face, and neck injuries in participants aged less than 13 years.After adjustment for activity, helmets were associated with a 43% reduction in the risk of head, face, and neck injuries, and no serious neck injury occurred in those using helmets.Our estimates for all age groups confirm the protective effect of helmets on head injuries found by this previous study. 3Although other investigators have examined the relation between helmet use and risk of neck injury in skiers and snowboarders, unlike us they did not examine this in isolation or did not report an effect estimate. 3