AB0551 CUTANEOUS LUPUS AREA AND SEVERITY INDEX(CLASI) CORRELATES WITH SELF-IMAGE SCORE BUT NOT QUALITY OF LIFE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: N. H. Malepati, D. Maikap, P. Padhan, R. Misra, S. Cr, S. Ahmed
Journal: Annals of the Rheumatic Diseases (2022)

Background Systemic lupus erythematosus (SLE) has multi-system involvement including skin. We explored how skin involvement influenced with the quality of life of patients with SLE. Objectives To correlate the domains of SLE QoL with skin involvement and total lupus disease activity. Methods A cross-sectional survey of patients with SLE was carried out to assess Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) and SLE-QoL. Lupus disease activity and damage were quantified using Mex-SLEDAI (Mexican SLE Disease Activity Index) and SLICC (Systemic Lupus International Collaborating Clinics) Damage Index respectively. Data is expressed as median (IQR). Results In the cohort of 35 patients with SLE, with an age of 26(IQR:17-32) years and including eight (22.8%) males, the CLASI score was 5.5(IQR:3-11.5) with an activity score of 3(1-5) and a chronicity score of 1(0-4). The disease duration was 4years (IQR: 2-3) while SLE-QoL was 73(62-86). Overall, most of the patients had active disease at inclusion with a mex-SLEDAI of 8(6.5-11.5). SLICC was 1(0-4). The correlation matrix of different domains of the SLE-QoL with CLASI, and Mex-SLEDAI is presented in Table 1. Correlation with SLICC was not analysed since it was zero in the majority of participants. Multivariate analyses were not done since there was lack of association on univariate analysis. Table 1. Correlations between different domains of the SLE(Systemic Lupus Erythematosus) -QoL(Quality of Life) with CLASI (Cutaneous Lupus Area and Severity Index) and Mexican SLE-DAI(SLE Disease Activity Index). SLE-QoL Domains Physical functioning Physical activity Symptoms Treatment Mood Selfimage Total CLASI Activity .028 -.062 .242 .103 .113 .252 .102 (p=0.87) (p=0.73) (p=0.16) (p=0.56) (p=0.52) (p=0.15) (p=0.56) CLASI Damage .125 .010 .257 .239 .233 .446** .243 (p=0.47) (p=0.95) (p=0.13) (p=0.17) (p=0.18) (p=0.007) (p=0.16) CLASI total .047 -.062 .448* .331 .332 .315 .281 (p=0.80) (p=0.75) (p=0.013) (p=0.07) (p=0.07) (p=0.09 (p=0.13) Mexican SLEDAI SCORE .001 .130 .390* .251 .115 .197 .200 (p=0.99) (p=0.47) (p=0.025) (p=0.16) (p=0.52) (p=0.27) (p=0.27) Conclusion In this cohort of patients with active SLE, the SLE-QoL did not correlate with either the overall disease activity score nor the skin specific score. Only the Self-image domain correlated with the skin score. This implies that in active disease, the skin involvement may have only a minor effect on the quality of life. References [1]Klein R, Moghadam-Kia S, LoMonico J, Okawa J, Coley C, Taylor L, Troxel AB, Werth VP. Development of the CLASI as a tool to measure disease severity and responsiveness to therapy in cutaneous lupus erythematosus. Archives of dermatology. 2011 Feb 1;147(2):203-8. [2]Leong KP, Kong KO, Thong BY, Koh ET, Lian TY, Teh CL, Cheng YK, Chng HH, Badsha H, Law WG, Lau TC. Development and preliminary validation of a systemic lupus erythematosus-specific quality-of-life instrument (SLEQOL). Rheumatology. 2005 Oct 1;44(10):1267-76. Disclosure of Interests None declared