tbuckley/cabot-search huggingface dataset:
<i>MUC5B</i>, telomere length and longitudinal quantitative interstitial lung changes: the MESA Lung Study
Authors: John S Kim, Ani W Manichaikul, Eric A Hoffman, Pallavi Balte, Michaela R Anderson, Elana J Bernstein, Purnema Madahar, Elizabeth C Oelsner, Steven M Kawut, Artur Wysoczanski, Andrew F Laine, Ayodeji Adegunsoye, Jennie Z Ma, Margaret A Taub, Rasika A Mathias, Stephen S Rich, Jerome I Rotter, Imre Noth, Christine Kim Garcia, R Graham Barr, Anna J Podolanczuk
Journal: Thorax (2022)

Background The MUC5B promoter variant (rs35705950) and telomere length are linked to pulmonary fibrosis and CT-based qualitative assessments of interstitial abnormalities, but their associations with longitudinal quantitative changes of the lung interstitium among community-dwelling adults are unknown. Methods We used data from participants in the Multi-Ethnic Study of Atherosclerosis with high-attenuation areas (HAAs, Examinations 1–6 (2000–2018)) and MUC5B genotype (n=4552) and telomere length (n=4488) assessments. HAA was defined as the per cent of imaged lung with attenuation of −600 to −250 Hounsfield units. We used linear mixed-effects models to examine associations of MUC5B risk allele (T) and telomere length with longitudinal changes in HAAs. Joint models were used to examine associations of longitudinal changes in HAAs with death and interstitial lung disease (ILD). Results The MUC5B risk allele (T) was associated with an absolute change in HAAs of 2.60% (95% CI 0.36% to 4.86%) per 10 years overall. This association was stronger among those with a telomere length below an age-adjusted percentile of 5% (p value for interaction=0.008). A 1% increase in HAAs per year was associated with 7% increase in mortality risk (rate ratio (RR)=1.07, 95% CI 1.02 to 1.12) for overall death and 34% increase in ILD (RR=1.34, 95% CI 1.20 to 1.50). Longer baseline telomere length was cross-sectionally associated with less HAAs from baseline scans, but not with longitudinal changes in HAAs. Conclusions Longitudinal increases in HAAs were associated with the MUC5B risk allele and a higher risk of death and ILD.
Usefulness of a forward-viewing echoendoscope in endoscopic ultrasound-guided recanalization for complete obstruction of the esophagus after chemoradiotherapy for esophageal cancer
Authors: Ikuhiro Kobori, Yasumi Katayama, Fuki Hayakawa, Masaru Kuwada, Yoshinori Gyotoku, Yumi Kusano, Masaya Tamano
Journal: Endoscopy (2022)

Complete obstruction of the esophagus after chemoradiotherapy for esophageal cancer is very rare and extremely difficult to treat. We report a recanalization using the rendezvous technique with endoscopic ultrasound (EUS) using a forward-viewing echoendoscope (TGF-UC260J; Olympus Medical) ([Fig. 1]).
Endoscopic salvage extraction of a fish bone impacted in a liver abscess by extra-anatomic cholangioscopy
Authors: Enrique Pérez-Cuadrado-Robles, Bernard El Khoury, Guillaume Perrod, Hadrien Alric, Gabrielle Martin, Christophe Cellier, Gabriel Rahmi
Journal: Endoscopy (2022)

Fish bones can migrate through the digestive tract to the liver parenchyma [1]. The endoscopic alternatives in these cases are limited and a surgical approach is often required [2].
Pyloric ring section with a papillotomy knife for removing an ingested plastic bag closure penetrating the pyloric ring
Authors: Yoshimasa Kubota, Tesshin Ban, Takaya Nagasaki, Takuya Takahama, Satoshi Tanida, Takashi Joh
Journal: Endoscopy (2022)

The European Society of Gastrointestinal Endoscopy's clinical guideline recommends urgent therapeutic esophagogastroduodenoscopy (EGD) for esophageal blunt foreign bodies (FBs) without complete obstruction. Delayed intervention decreases the likelihood of successful FB removal and increases the risk of complications. However, non-urgent therapeutic EGD using suitable extraction devices is recommended, depending upon the type and location of blunt FBs in the stomach [1]. This article describes an endoscopic pyloric ring section procedure for removing an accidentally ingested blunt FB lodged in the pyloric ring (p-ring) like an earring.
Endoscopic extraction of migrated gastric bypass Fobi ring in patient after gastric bypass
Authors: Jan Kral, Jan Selucka, Filip Dolecek, Katerina Waloszkova, Marek Buzga, Julius Spicak, Evzen Machytka
Journal: Endoscopy (2022)

A 47-year-old patient previously underwent laparoscopic gastric bypass for obesity (body mass index 56.2 kg/m2) followed by gastric bypass Fobi ring (GBFR) placement 5 years later. The patient was referred to the endoscopy unit due to epigastric pain, which eased on intake of proton pump inhibitors or food. Initial gastroscopy examination showed that the GBFR had migrated intragastrically. A second endoscopy was planned to extract the migrated GBFR ([Video 1]).
Endoscopic full-thickness resection of IgG4-related gastric submucosal tumor-like lesion
Authors: Tsukasa Ishida, Yahaya Bensuleiman, Masaru Takimoto, Koki Matsuoka, Takatoshi Nakashima
Journal: Endoscopy (2022)

IgG4-related disease (IgG4-RD) is an immune-mediated disorder in which abundant IgG4-positive plasma cells infiltrate the affected organs. IgG4-RD presenting as a submucosal tumor of the stomach is rare, and preoperative diagnosis is difficult. Herein, we demonstrate endoscopic full-thickness resection (EFTR) of IgG4-RD presenting as a submucosal stomach tumor for the first time.
Management of afferent loop obstruction using multiple single-pigtail plastic stents in a patient with recurrent metastatic pancreatic cancer
Authors: Koichi Soga, Hiroki Mukai, Hiroaki Kitae
Journal: Endoscopy (2022)

Malignant afferent loop obstruction (mALO) is defined as duodenal or jejunal mechanical obstruction at the proximal anastomosis site of a gastrojejunostomy associated with locoregional tumor recurrence. As the general condition of patients with tumor recurrence is poor, accurate and rapid diagnosis and minimally invasive treatment are required [1].
Hemosuccus pancreaticus: an in-motion endoscopic ultrasound view
Authors: Ilaria Tarantino, Giacomo E. M. Rizzo, Dario Ligresti, Agita Jukna, Luigi Maruzzelli, Salvatore Gruttadauria, Mario Traina
Journal: Endoscopy (2022)

A 77-year-old man was transferred to our institution due to gastrointestinal (GI) bleeding of unknown origin. Bleeding had caused permanent melena during the preceding month, with consequent severe anemia (up to 5.3 g/dL hemoglobin) requiring blood transfusion. Because of his cardiovascular comorbidities (cardiopathy, atrial fibrillation, and type II diabetes), the patient was on anticoagulation therapy, which was paused after GI bleeding started. During his previous hospital stay at another institution, the patient underwent computed tomography scan, gastroscopy, colonoscopy, magnetic resonance imaging, magnetic resonance cholangiopancreatography, endoscopic ultrasound (EUS), and red blood cell scintigraphy. Despite these procedures, the site of GI bleeding was not clear, showing only diffuse blood in the duodenum and a suspected hypoechoic pancreatic area on EUS. Laboratory tests were normal, and neoplastic biomarkers were within the normal range.
Diagnostic esophagogastroduodenoscopy performed using a novel sterile single-use disposable endoscope
Authors: Ronja Lagström, Trine Stigaard, Svend Knuhtsen, Mustafa Bulut
Journal: Endoscopy (2022)

Growth of biofilm in the channels of endoscopes is common [1]. Damage to the channels, followed by formation of biofilm, may occur during both endoscopic procedures and the cleaning process. Biofilm is difficult to remove, and microbial contamination increases with the age of the endoscope [2]. The quality of reprocessing of endoscopes is believed to be associated with the contamination rate [3]. These aspects are not relevant for single-use endoscopes.
Endoscopic submucosal dissection of an ileocecal valve laterally spreading tumor using an adaptable magnetic traction system
Authors: Jean Grimaldi, Thomas Lambin, Jérôme Rivory, Louis-Jean Masgnaux, Mathieu Pioche
Journal: Endoscopy (2022)

Traction-assistance is very effective in facilitating endoscopic submucosal dissection (ESD) of superficial colorectal lesions [1], notably in the case of difficult locations such as the ileocecal valve. We have recently developed a multitraction strategy to increase the efficacy of traction for lesions in such locations, using a rubber band to connect the different traction points [2]. A new magnetic traction device (ProdiGI Traction Magnet, Medtronic) has been developed that allows adjustment of the traction strategy during the procedure ([Fig. 1 a, b]; [Video 1]).
Antegrade balloon dilation of the minor duodenal papilla to facilitate serial pancreatic juice aspiration cytology
Authors: Koichiro Mandai, Ryo Shinomiya
Journal: Endoscopy (2022)

Repeated pancreatic juice cytology via a nasopancreatic drainage (NPD) catheter, known as serial pancreatic juice aspiration cytologic examination (SPACE), is reportedly useful for the diagnosis of early-stage pancreatic cancer [1]. When NPD catheter insertion through the major papilla is impossible due to main pancreatic duct (MPD) distortion, insertion through the minor papilla is attempted. Here, we describe antegrade dilation of the minor papilla using a balloon catheter inserted through the major papilla to facilitate minor papilla cannulation and NPD catheter insertion.
How should aerosol generating procedures be defined?
Authors: Jason Chui, David SC Hui, Matthew TV Chan
Journal: BMJ (2022)

How this article was createdWe performed a systematic search of the literature in Medline, Embase, the Cochrane CENTRAL register of controlled trials and the Cochrane Database of systematic reviews from January 2000 to April 2021.We used the search terms "exp Coronavirus/", "exp Coronavirus Infections/", "Severe Acute Respiratory Syndrome/", "(covid or SARS or SARS-CoV or pandemic)*" or "severe acute respiratory syndrome coronavirus" or "SARS-CoV-2" or "COVID-19" or "2019-nCov" or "coronavirus" or "2019 novel coronavirus"* or "wuhan").ti,ab."AND "exp Aerosols/", "exp Personal Protective Equipment/", "exp Particulate Matter/", "Lipid Droplets/", "exp Lipid Droplet Associated Proteins/", "exp Cross Infection/" , or "aerosol*" or "airborne*" or "droplet*" or "transmit*", or "health*" and "work*" and "safe*" or "respiratory therap*" or "airway manag*" or "non-invasive ventilation" or "oxygen device*" or "nasal cannula" or "nebulizer").ti,ab.We screened 4618 articles, and further performed a snowball search from the bibliography of the included articles.
Different methods of traction employed during endoscopic submucosal dissection of early cancers
Authors: Shahila Perveen Aslam, Hein Htet, Katie Siggens, Mohamed Abdelrahim, Pradeep Bhandari
Journal: Endoscopy (2022)

Endoscopic submucosal dissection (ESD) is an accepted technique for en bloc excision of gastrointestinal neoplasia. One of the main challenges during ESD is lack of traction to open the submucosal plane for dissection and to avoid muscle injury.
Expanding rather than closing the wound can rescue the endoscopic procedure when massive bleeding occurs during endoscopic submucosal dissection
Authors: Ming-Ching Yuan, Ching-Tai Lee, Kun-Feng Tsai, Chao-Wen Hsu, Chu-Kuang Chou
Journal: Endoscopy (2022)

Bleeding is a challenging complication during endoscopic submucosal dissection (ESD) [1]. Some bleeding during gastric ESD is hard to control, with a few papers having discussed techniques to control the bleeding [2] [3]. Electrocoagulation and hemoclips are available tools. The idea of expanding the surgical field is common for surgeons; however, the concept of building the working field to get better visualization by expanding the wound is rarely discussed in the field of endoscopic hemostasis.
Underwater endoscopic mucosal resection of colon hemangiomas compatible with the blue rubber bleb nevus syndrome, following endoscopic ultrasonography
Authors: Yuko Shibuya, Masahiro Okada, Munefumi Arita, Yoshikazu Hayashi, Hirotoshi Kawata, Alan Kawarai Lefor, Hironori Yamamoto
Journal: Endoscopy (2022)

Blue rubber bleb nevus syndrome (BRBNS) is a rare congenital disease with venous malformations on the skin and in the gastrointestinal tract. Gastrointestinal venous malformations frequently cause bleeding and/or iron deficiency anemia [1]. Endoscopic approaches such as endoscopic mucosal resection [2], electrocoagulation, sclerotherapy, and ligation [3] have been reported for the treatment of symptomatic gastrointestinal hemangiomas associated with BRBNS. Recently, underwater endoscopic mucosal resection (UEMR) has rapidly been becoming a game-changing technique for endoscopic polyp resection. UEMR is usually simpler, cheaper, and more reliable than other conventional endoscopic resection techniques. When endoscopic ultrasonography (EUS) is performed prior to UEMR, EUS can allow prediction of the safety and reliability of UEMR because lesion characteristics such as depth, blood vessels, and echodensity are evaluated [4]. We illustrate a case in which colon hemangiomas compatible with BRBNS were resected endoscopically using UEMR.
A simple endoscopic treatment for large gastric bezoars: the guidewire and snare method
Authors: Yagang Li, Jiajun Lu, Wei Lei, Yiting Liu, Meidi Liu, Haidong Bao, Jian Gong
Journal: Endoscopy (2022)

Although endoscopic treatment has been widely used for treating gastric bezoars, bezoars with a large diameter are still hard to handle for endoscopists. There have already been reports about applying guidewires in treating bezoars [1] [2]. However, the special instruments needed are not commonly available, which has limited extensive application of endoscopic treatment. In this regard, we established a simple endoscopic treatment for large gastric bezoars by using a guidewire and a snare.
Efficacy of a gel injected using an endoscopic water jet for visualization of active bleeding during esophageal endoscopic submucosal dissection
Authors: Takashi Ueda, Masaya Sano, Hideki Mori, Hidekazu Suzuki
Journal: Endoscopy (2022)

Active bleeding often occurs during esophageal endoscopic submucosal dissection (ESD), making it difficult to identify the bleeding point. During esophageal ESD, bleeding on the left wall of the esophagus is often difficult to visualize because of the difficulty of the patient's changing position. We report a new method using a gel product to secure the visual field of esophageal ESD when hemostasis is difficult.
Successful detection of choledochojejunal and pancreaticojejunal anastomotic strictures using a novel form of texture and color enhancement imaging
Authors: Haruka Toyonaga, Toshifumi Kin, Risa Nakamura, Tatsuya Ishii, Kosuke Iwano, Kuniyuki Takahashi, Akio Katanuma
Journal: Endoscopy (2022)

Although the effectiveness of image-enhanced endoscopy (IEE) has been widely reported in the management of gastrointestinal tract lesions [1], its effectiveness in the pancreaticobiliary region is not yet established. Recently, a novel IEE tool called texture and color enhancement imaging (TXI; Olympus, Tokyo, Japan) has been launched; TXI has two modes: mode 1, which enhances brightness, texture, and color contrast; and mode 2, which enhances brightness and texture [2]. Herein, we report two cases in which we successfully detected the sites of choledochojejunal and pancreaticojejunal anastomotic strictures using TXI ([Video 1]).
Gastric peroral endoscopic myotomy for the resection of a predominantly extraluminal submucosal tumor in the duodenal bulb
Authors: Li Wang, Zu-Qiang Liu, Quan-Lin Li, Ping-Hong Zhou
Journal: Endoscopy (2022)

A 53-year-old man was admitted with a duodenal submucosal tumor ([Fig. 1 a,b]) that had been detected on a regular physical examination. Because the tumor was located on the posterior wall of the duodenal bulb near the pylorus and had predominantly extraluminal growth, it would have been difficult to perform endoscopic full-thickness resection and close the wound. Therefore, we proposed performing a gastric peroral endoscopic myotomy (G-POEM), which allowed the tumor to be removed using the tunnel technique, while maintaining the integrity of the duodenal mucosa ([Video 1]).
The combination needle injection-incision technique using the two-in-one needle-snare device for knife-assisted resection
Authors: Brigita Petrik, Alvaro Martínez-Alcalá, Katarzyna Pawlak, Klaus Mönkemüller
Journal: Endoscopy (2022)

In order to perform advanced resections that require submucosal injection of substances such as endoscopic submucosal dissection (ESD) or hybrid endoscopic submucosal dissection/endoscopic mucosal resection (ESD-EMR), several instruments are required, including an injection needle, incision needle, and dissection knives and/or snaring devices [1] [2] [3] [4] [5]. The present report describes a novel and simple method that involves using a two-in-one device that combines a needle and a snare.
Endoscopic submucosal dissection with a novel traction wire for esophageal cancer in the cervical esophagus
Authors: Kyosuke Tanaka, Koyo Kido, Shoma Sawai, Yohei Ikenoyama, Hiroki Yukimoto, Yasuhiko Hamada, Hayato Nakagawa
Journal: Endoscopy (2022)

Endoscopic submucosal dissection (ESD) for cervical esophageal cancer is challenging owing to unstable endoscopic maneuverability. Various assistive devices have been developed for esophageal ESD. A traction wire (ProdiGI Traction Wire, ERD-TW20; Medtronic, Minneapolis, Minnesota, USA) is a unique traction device consisting of a curved wire loop with a grasping clip [1] [2] [3] [4] [5].
Iatrogenic colonic perforation closure with an over-the-scope clip applied with a gastroscope 4 hours after index colonoscopy
Authors: Pinelopi Nicolaou, Magdalini Velegraki, Despoina Arna, Andrew Psistakis, Emmanouil Bachlitzanakis, Matthaios Flamourakis, Gregorios A. Paspatis
Journal: Endoscopy (2022)

Endoscopic treatment of colonic acute iatrogenic perforations (AIPs) recognized during or shortly after the procedure has been recommended as a first-line approach [1] [2] [3] [4] [5], even for perforations occurring during diagnostic colonoscopies, which are considered larger than those occurring during therapeutic colonoscopies. However, the approximate time frame has not been defined. Experts recommend the marginal time of 4 hours after the colonoscopy. We report the closure of an AIP with an over-the-scope (OTS) clip, mounted on a gastroscope, 4 hours after the endoscopic view of the defect.
Novel technique for treating simple hepatic cysts: endoscopic transgastric hepatic cyst deroofing
Authors: Congying Chen, Ruling Zhang, Rong Wan
Journal: Endoscopy (2022)

Simple hepatic cysts are common benign liver lesions which are usually asymptomatic and discovered incidentally. However, larger lesions may need surgical treatment if patients present with abdominal pain, epigastric fullness, or early satiety [1]. American Society of Gastroenterology clinical practice guidelines recommend that symptomatic simple hepatic cysts may be managed with laparoscopic deroofing rather than aspiration and sclerotherapy [2]. Natural-orifice transluminal endoscopic surgery (NOTES) has been developed as a step towards less invasive procedures [3]. With the development of digestive endoscopy, some researchers have used endoscopic ultrasound-guided fine-needle aspiration or NOTES technology for cystic fluid aspiration. Herein, we report a novel approach to smoothly achieving unroofing of simple hepatic cysts, called endoscopic transgastric hepatic cyst deroofing (ETGHCD).
Cemiplimab plus chemotherapy versus chemotherapy alone in non-small cell lung cancer: a randomized, controlled, double-blind phase 3 trial
Authors: Miranda Gogishvili, Tamar Melkadze, Tamta Makharadze, Davit Giorgadze, Mikhail Dvorkin, Konstantin Penkov, Konstantin Laktionov, Gia Nemsadze, Marina Nechaeva, Irina Rozhkova, Ewa Kalinka, Christian Gessner, Brizio Moreno-Jaime, Rodolfo Passalacqua, Siyu Li, Kristina McGuire, Manika Kaul, Anne Paccaly, Ruben G. W. Quek, Bo Gao, Frank Seebach, David M. Weinreich, George D. Yancopoulos, Israel Lowy, Giuseppe Gullo, Petra Rietschel
Journal: Nature Medicine (2022)

Abstract First-line cemiplimab (anti-programmed cell death-1 (PD-1)) monotherapy has previously shown significant improvement in overall survival (OS) and progression-free survival (PFS) versus chemotherapy in patients with advanced non-small cell lung cancer (aNSCLC) and PD-ligand 1 (PD-L1) expression ≥50%. EMPOWER-Lung 3 ( NCT03409614 ), a double-blind, placebo-controlled, phase 3 study, examined cemiplimab plus platinum-doublet chemotherapy as first-line treatment for aNSCLC, irrespective of PD-L1 expression or histology. In this study, 466 patients with stage III/IV aNSCLC without EGFR , ALK or ROS1 genomic tumor aberrations were randomized (2:1) to receive cemiplimab 350 mg ( n = 312) or placebo ( n = 154) every 3 weeks for up to 108 weeks in combination with four cycles of platinum-doublet chemotherapy (followed by pemetrexed maintenance as indicated). In total, 57.1% (266/466 patients) had non-squamous NSCLC, and 85.2% (397/466 patients) had stage IV disease. The primary endpoint was OS. The trial was stopped early per recommendation of the independent data monitoring committee, based on meeting preset OS efficacy criteria: median OS was 21.9 months (95% confidence interval (CI), 15.5–not evaluable) with cemiplimab plus chemotherapy versus 13.0 months (95% CI, 11.9–16.1) with placebo plus chemotherapy (hazard ratio (HR) = 0.71; 95% CI, 0.53–0.93; P = 0.014). Grade ≥3 adverse events occurred with cemiplimab plus chemotherapy (43.6%, 136/312 patients) and placebo plus chemotherapy (31.4%, 48/153 patients). Cemiplimab is only the second anti-PD-1/PD-L1 agent to show efficacy in aNSCLC as both monotherapy and in combination with chemotherapy for both squamous and non-squamous histologies.
Checkpoint inhibitor immunotherapy diminishes oocyte number and quality in mice
Authors: Amy L. Winship, Lauren R. Alesi, Sneha Sant, Jessica M. Stringer, Aldana Cantavenera, Teharn Hegarty, Carolina Lliberos Requesens, Seng H. Liew, Urooza Sarma, Meaghan J. Griffiths, Nadeen Zerafa, Stephen B. Fox, Emmaline Brown, Franco Caramia, Pirooz Zareie, Nicole L. La Gruta, Kelly-Anne Phillips, Andreas Strasser, Sherene Loi, Karla J. Hutt
Journal: Nature Cancer (2022)
Analyzing cell-type-specific dynamics of metabolism in kidney repair
Authors: Gangqi Wang, Bram Heijs, Sarantos Kostidis, Ahmed Mahfouz, Rosalie G. J. Rietjens, Roel Bijkerk, Angela Koudijs, Loïs A. K. van der Pluijm, Cathelijne W. van den Berg, Sébastien J. Dumas, Peter Carmeliet, Martin Giera, Bernard M. van den Berg, Ton J. Rabelink
Journal: Nature Metabolism (2022)

Abstract A common drawback of metabolic analyses of complex biological samples is the inability to consider cell-to-cell heterogeneity in the context of an organ or tissue. To overcome this limitation, we present an advanced high-spatial-resolution metabolomics approach using matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) combined with isotope tracing. This method allows mapping of cell-type-specific dynamic changes in central carbon metabolism in the context of a complex heterogeneous tissue architecture, such as the kidney. Combined with multiplexed immunofluorescence staining, this method can detect metabolic changes and nutrient partitioning in targeted cell types, as demonstrated in a bilateral renal ischemia–reperfusion injury (bIRI) experimental model. Our approach enables us to identify region-specific metabolic perturbations associated with the lesion and throughout recovery, including unexpected metabolic anomalies in cells with an apparently normal phenotype in the recovery phase. These findings may be relevant to an understanding of the homeostatic capacity of the kidney microenvironment. In sum, this method allows us to achieve resolution at the single-cell level in situ and hence to interpret cell-type-specific metabolic dynamics in the context of structure and metabolism of neighboring cells.