tbuckley/cabot-search huggingface dataset:
DNA Alkylation and Tumor Induction in Regenerating Rat Liver After Cell Cycle-Related Continuous &lt;italic&gt;N&lt;/italic&gt;-Nitrosodimethylamine Infusion&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Hartmut M. Rabes, Rosi Kerler, Roland Wilhelm
Journal: JNCI Journal of the National Cancer Institute (1983)

Synchronized regenerating rat liver after partial hepatectomy was used to study cell cycle-related DNA base alkylation and liver carcinogenesis. A continuous iv infusion of [14C]N-nitrosodimethylamine (DMN) at a dose of 0.5 mg/kg/hour was given to inbred male Wistar Af/Han rats over a period of 8 hours either during the G1 phase, hydroxyurea-synchronized DNA synthesis, or the G2+M-phase of regenerating liver or to untreated rats (G0-phase liver-carcinogen dose, 1.5 mg/kg/hour). Two hours after the end of the infusion, the amount of 7-methylguanine was highest in the G0-phase liver, with a decrease in the G1 phase, the S-phase, and the G2+M-phase. After continuous DMN exposure, the O6-methylguanine:7-methylguanine ratio was lower in the S-phase and G2+M-phase livers than in the G0-phase and G1-phase livers, indicating an increased 06-methylguanine repair during DNA synthesis and the G2+M-phase. Liver tumors in rats treated by continuous DMN infusion either during the G0 phase or the S-phase developed only after carcinogen exposure during DNA synthesis.
Cervical screening: what is the point?
Authors: Peter Sasieni, KarinJ. Denton, W.P. Soutter, Jeffrey Robertson, Bertha Woodend, Doreen Campbell, LeopoldG. Koss, P.P. Anthony, T.J. Clarke, Peter McCartney, A.E. Raffle, E.F.D. Mackenzie, B. Alden
Journal: The Lancet (1995)
Aspirin's Role in Prevention Now Official
Authors: Charles Marwick
Journal: JAMA (1997)

ASPIRIN is about to get broader official recognition as a useful agent in the prevention of heart attack and stroke. But it will be no news to those physicians who have been prescribing aspirin for their patients at risk of cardiovascular disease. Meeting jointly, 2 Food and Drug Administration (FDA) advisory committees, Cardio-Renal Drugs and Nonprescription Drugs, have recommended to the FDA commissioner that he approve the use of aspirin as a preventive measure in patients who are at high risk for cardiovascular disease but do not have a history of a myocardial infarction (MI) or have stable angina. Aspirin is currently recommended to reduce the risk of death or a nonfatal MI only in patients with a previous history of MI or in those with unstable angina. "When it's approved, it will be a major addition to the claims structure for aspirin. There are a lot of people with
Ergebnisse der Enzymforschung.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human Blood Coagulation and Its Disorders
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radiology's Stepchild—the Colon
Authors: Frank Edmondson
Journal: JAMA (1971)

The examination is technically unsatisfactory due to retained fecal material but no gross abnormalities are visible within the colon. A small intraluminal lesion cannot be excluded. This paraphrased reading is placed on x-ray film reports every day, and the subject patients are probably told that the colon is normal. In most cases, the colon is normal— but only due to the laws of statistics which apply to survey examinations. What, alas, if the unfortunate patient harbors a small carcinoma or polyp in a redundant, fecal-filled colon? The startling fact must now be faced that 15% of carcinomas of the colon are flatly missed on the initial barium enema examination, according to Dr. Grant Saunders of Winnepeg, Manitoba. He reported on reasons for delay in diagnosing colon carcinoma at the Radiologic Society of North America in Chicago in December 1970. One of the major reasons for delay in diagnosis was that
The Treatment of Paget's Disease of Bone
Authors: John Haddad
Journal: JAMA (1969)

Dr. David Hirschfeld, Junior Assistant Resident in Medicine, Jewish Hospital of St. Louis; and Assistant in Medicine, Washington University School of Medicine: A 62-year-old white woman was referred to this hospital in October 1968 for evaluation of Paget's disease, which was initially diagnosed by x-ray film in 1961 during intravenous pyelographic studies. The patient remained asymptomatic until 1963 when pain in the left side of the pelvis and left upper leg was noted. These symptoms have persisted with variable intensity to the present time. In 1967 the patient was subsequently seen at another institution and on two occasions received intravenously administered radioactive phosphorus therapy (sodium phosphate P32) for the complaints. In each instance, the administration of the isotope was apparently associated with symptomatic improvement of the bone pain. The patient denied any history of bone fracture or renal calculi. Physical examination revealed a middle-aged woman in no acute distress. Pulse
Physician's Management of the Psychological Aspects of Rape
Authors: Catherine A. Martin
Journal: JAMA (1983)

RAPE IS reported to be the fastestgrowing violent crime,<sup>1</sup>and it is estimated that one of six women will be raped in her lifetime.<sup>2</sup>Because of the increasing frequency of rape and accompanying severe emotional and physical trauma, the physician should be able to be sensitive to the psychological needs of the rape victim. This article discusses the psychological sequelae of rape and provides guidelines on how to lessen the psychological trauma, so that the rape victim will be able to better cope with this devastating experience. <h3>Post-traumatic Stress Disorder</h3> Many rape victims may suffer from a post-traumatic stress disorder. This is defined in the third edition of the<i>Diagnostic and Statistical Manual of Mental Disorders (DSM-III)</i><sup>3</sup>as the development of characteristic symptoms after the experiencing of a psychologically traumatic event or events outside the range of human experience usually considered to be normal. The characteristic symptoms
Health surveillance of preschool children.
Authors: A F Colver, H Steiner
Journal: BMJ (1986)

Discussions with every general practice, health visitor, and clinical medical officer in Northumberland Health Authority led to agreement about the content of preschool health surveillance, the ages at which it should be done, and referral pathways after a failed screening test. Each primary health care team now undertakes to do a basic minimum set of screening tests, and each team decides who in the team will do each test. The screening system agreed on should enable time to become available for the equally important aspects of surveillance--namely, developmental guidance, health education, and assessment and follow up of problems. The discussions also led to agreement about how the health authority should evaluate the effect of the surveillance programme on the health of children.
Testing for AIDS: more problems with predictive values
Authors: R. S. Wallis
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights of This Issue
Journal: Clinical Cancer Research (2013)

Tivantinib (ARQ197), a staurosporine derivative that binds to the dephosphorylated MET kinase in vitro, is being tested clinically as a highly selective Met inhibitor. The recent failure of a phase III trial in lung cancer and a phase II trial in colon cancer could raise concerns about the validity of MET as a therapeutic target. However, Basilico and colleagues provide evidence that tivantinib is not a MET inhibitor but an antimitotic agent that promotes microtubule stabilization and kills tumor cells independently of MET. This notion has a relevant impact on the interpretation of clinical results, on the design of future clinical trials, and on the selection of patients receiving tivantinib treatment.Stromal interactions that sustain chronic inflammation and predispose to cancer are poorly understood. Khan and colleagues used a potent inhibitor of phosphoinositide 3-kinase (PI3K) that is currently in clinical use in combination with ex vivo assays and animal modeling to elucidate the contribution of stromal PI3K activity to the recruitment of inflammatory cells and predisposition to cancer. They found that in contrast with mouse models of colitis, in which PI3K activity is mostly in the epithelial cells, human colitis and colitis-associated cancer recruit PI3K-active proinflammatory cells in the stroma and are the target for PI3K inhibitors in prevention and therapy of inflammation-induced colon cancer.miR-29b has a putative tumor suppressor activity. High miR-29b expression has been associated with better outcomes in patients with acute myeloid leukemia (AML), hence the hypothesis that therapeutic increase of miR-29b is beneficial. Huang and colleagues developed a novel targeting nanoparticle-based system to deliver synthetic miR-29b to AML blasts. The treatment downregulated known AMLassociated miR-29b targets, including the receptor tyrosine kinases FLT3 and KIT, which are frequently mutated and aberrantly active in AML. The treatment resulted in antileukemic activity, sensitization effects to the hypomethylating agent decitabine, and improved survival in a murine AML model. These preclinical results support development of miR-29b replacement therapy as a novel therapeutic approach in AML.Genetic missense variants present a considerable problem in diagnosing Lynch syndrome, one of the most common hereditary cancer predispositions. Most of them occur so infrequently that it is unclear if they are causative or casual bystanders. Hinrichsen and colleagues established an assay that determines MLH1 variant pathogenicity based on its expression level. This was achieved by identifying clinically wellcharacterized variants that serve as controls. A threshold distinguishes clinically neutral from pathogenic expression defects. These findings provide the chance to facilitate proper targeting of cancer prevention in affected families.
Final Exit and the Risk of Suicide
Authors: Phillip B. Chappell
Journal: JAMA (1992)

<h3>To the Editor.</h3> —Critics of the controversial book<i>Final Exit</i><sup>1</sup>have cautioned that it may encourage and facilitate suicide among individuals with treatable psychiatric disorders.<i>2,3</i>Even among the infirm elderly and those with serious medical disorders, suicide is often secondary to potentially remediable psychological factors rather than intractable pain or inexorable death.<sup>3,4</sup>With its lurid examples, explicit instructions, and vigorous advocacy for suicide,<i>Final Exit</i>may have an especially pernicious effect on adolescents, who, with their high rates of attempted and completed suicide, appear susceptible to imitative influences and cultural factors that glorify or destigmatize suicide.<sup>5</sup>The following case report illustrates the potential dangers of facilitating adolescent suicidality. Two 14-year-old girls, A and B, were referred by their school principal for emergency psychiatric assessment after each accused the other of being suicidal. Girl A had recently purchased<i>Final Exit</i>, brought it to school, and gave it
Highlights from Recent Cancer Literature
Journal: Cancer Research (2016)

Than an RTK Inhibitor?Cetuximab, a chimeric monoclonal antibody against EGFR, is used for treatment of colorectal carcinoma.Pozzi and colleagues investigate how immunogenic tumor cell death contributes to cetuximab's efficacy.In colorectal carcinoma lines, cetuximab induced endoplasmic reticulum (ER) stress, with increased phosphorylation of EIF2a and translocation of ER proteins to the cell surface.Through an Fc receptor-independent process, cetuximab, but not chemotherapy, increased phagocytosis of tumor cells by monocyte-derived dendritic cells.In vivo, cetuximab induced phagocytosis of tumor cells, leading to a protective antitumor CD8-T cell response.Cetuximabinduced apoptosis and phagocytosis was not uniform across cell lines.Their studies also suggest that activated BRAF or MEK may resolve ER stress by activating the unfolded protein response and promoting splicing of XBP1.Thus, the efficacy of cetuximab may be improved in some patients by inhibition of the BRAF-MEK pathway or of XBP1 splicing.(Image courtesy of Wikimedia Commons.)
The Clinical Use of Fluid and Electrolyte.
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Textbook of Medical Treatment
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Meeting Abstracts: Introduction
Authors: S Jowett, C Seal, J Barton, M Welfare, S Bartram, R Francis, N Thompson, A Sinha, J Nightingale, K West, J Berlanga-Acosta, R Playford, N Croft, E Kelly, K Bannerjee, K Dryhurst, I Sanderson, D Meister, M Aldhous, J Bode, A Shand, W Johnson, S Given, S Ghosh, K Leiper, J Woolner, M Mullan, T Parker, M Van Der Vleit, S Fear, J Rhodes, J Hunter
Journal: Gut (2001)

Background: Several tools exist to assess disease activity in patients with UC.The Simple Clinical Colitis Activity Index (SCCAI; Walmsley RS et al.Gut 1998;43:29-32) is a validated symptom based index (score 0-19) which has a good correlation with more complicated disease activity indices.However the score which defines a relapse has not been determined.Aims: To determine a) the validity of the SCCAI when self-administered, b) the score that defines a relapse c) the correlation with existing disease activity indices.Method: UC patients routinely attending hospital completed a 6 point questionnaire, the same questionnaire was later administered by the attendant physician who was blinded to the scoring process.As no gold standard for defining relapse exists the attendant physician made a global assessment of relapse/ remission status using the available clinical, laboratory & endoscopic evidence.Results: Scores were obtained for 74 presentations; age range 16-79 years, 51% male, 34% relapse rate.The mean patient score was 4.1 (range 0-14) & mean physician score 3.7 (0-14).There was excellent correlation between the scores obtained by the patient & physician (mean diVerence of 0.38, 95% CI 0.10-0.65).The self-administered SCCAI correlated well with a more complicated symptom & laboratory based activity index (Seo M et al.Am J Gastroenterol 1992;87:971-6) (r=0.77,p<0.01).The receiver-operator curve demonstrates the performance of the SCCAI scores in determining relapse.A score of 5 or more defines relapse with 92% sensitivity, 91% specificity, 85% positive predictive value & 89% negative predictive value. Conclusions:The SCCAI is a simple tool that can be accurately self administered, correlates well with a more complicated disease activity index, & can be used to define relapse of UC with high specificity & sensitivity.
Atlas of Peripheral Nerve Injuries.
Journal: Annals of Internal Medicine (1950)

This book is an unusual monograph on the interpretation of pain.The authors believe that the presence of tenderness, and its distribution, whether local or segmental, is of great aid in diagnosis and therapy.Their premises are that the combination of segmental pain and tenderness are usually due to factors which irritate roots, ganglia or trunks of the spinal sensory nerves, rather than to painful impulses orig- inating in diseased viscera.In other words, pain and seg- mental tenderness of skin in most instances appears to them to be of somatic rather than of visceral origin.As in many theses, sometimes the implications go beyond the demonstration of the proof.However, the book has much to offer.In Chapter II, for example, the desirability of improvement of posture is emphasized and the way to accom- plish it is pointed out.In Chapter IX it is brought out that pronounced pain and tenderness of the abdomen, as a car- dinal symptoin, is not caused by adhesions unless other symptoms are also present.In chapters III and VIII the authors return again and again to their main thesis, that persistent segmental pain is the result of lesions in or affect- ing the spinal nerves.In Chapter VIII, too, are developed arguments against the Head-McKenzie theory of visceral sensory reflex pain and the reliability of Murphy's sign.The last portion of the book is given to the technique of inijection for neuralgia.The photographs and diagrams are
Persistent Hyperparathyroidism Caused by Incomplete Parathyroid Resection and a Hyperfunctioning Parathyroid Autograft
Authors: Allen M. Spiegel
Journal: JAMA (1983)

A case of familial primary hyperparathyroidism occurred in which persistent hypercalcemia was caused by hyperplastic parathyroid tissue left in the neck and mediastinum after initial surgery and by a hyperfunctioning parathyroid autograft in the forearm. Successful therapy required parathyroid localization and resection of tissue from the neck, mediastinum, and forearm. Parathyroid tissue should be autotransplanted at the time of initial surgery only when total parathyroidectomy is judged likely to have been achieved. (<i>JAMA</i>1983;250:1896-1898)
Great Teachers of Surgery in the Past.
Journal: Annals of Internal Medicine (1969)

Reviews 1323 surprising inclusions.Several drawings are in- accurate, and too small and fussy.Greater integration in the text would have avoided omissions of clinically important biomechanical studies of the trunk, as yet undescribed in any textbook.Salutary criticism from nonspecialists makes for brevity and clarity, but pruning is for experts.Collaboration of both throughout the next edition would make for better balance and an even more coherent synthesis.Good plates, type, paper and binding make for easy reading.The index is useful.The addition of more references to original papers and brief reviews would encourage students to explore the literature.