tbuckley/cabot-search huggingface dataset:
Challenges to Forming Physician Unions
Authors: Carol A. Westbrook
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The future of food allergy: Challenging existing paradigms of clinical practice
Authors: Aikaterini Anagnostou, Jay Lieberman, Matthew Greenhawt, Douglas Paul Mack, Alexandra F. Santos, Carina Venter, David Stukus, Paul J. Turner, Helen A. Brough
Journal: Allergy (2023)

The field of food allergy has seen tremendous change over the past 5-10 years with seminal studies redefining our approach to prevention and management and novel testing modalities in the horizon. Early introduction of allergenic foods is now recommended, challenging the previous paradigm of restrictive avoidance. The management of food allergy has shifted from a passive avoidance approach to active interventions that aim to provide protection from accidental exposures, decrease allergic reaction severity and improve the quality of life of food-allergic patients and their families. Additionally, novel diagnostic tools are making their way into clinical practice with the goal to reduce the need for food challenges and assist physicians in the-often complex-diagnostic process. With all the new developments and available choices for diagnosis, prevention and therapy, shared decision-making has become a key part of medical consultation, enabling patients to make the right choice for them, based on their values and preferences. Communication with patients has also become more complex over time, as patients are seeking advice online and through social media, but the information found online may be outdated, incorrect, or lacking in context. The role of the allergist has evolved to embrace all the above exciting developments and provide patients with the optimal care that fits their needs. In this review, we discuss recent developments as well as the evolution of the field of food allergy in the next decade.
Challenges to Forming Physician Unions—Reply
Authors: Barak D. Richman, Kevin A. Schulman
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Arsenic exposure and pruritus: Evidence from observational, interventional, and mendelian randomization studies
Authors: Xiaoyan Huang, Yi Xiao, Danrong Jing, Yuzhou Huang, Songchun Yang, Zhijun Huang, Guoping Yang, Yanying Duan, Meian He, Juan Su, Mingliang Chen, Xiang Chen, Minxue Shen
Journal: Allergy (2023)

Pruritus is identified as an adverse drug reaction to arsenic trioxide, but the association of arsenic exposure with pruritus has not been investigated.A cross-sectional study was conducted in Shimen, China. A Mendelian randomization analysis was conducted to confirm the causal relationship between genetically predicted percentages of monomethylated arsenic (MMA%) and dimethylated arsenic (DMA%) in urine with chronic pruritus in UK Biobank. A case-control study was then conducted to determine the biomarker for pruritus. Arsenite-treated mice were used to confirm the biomarker, and von Frey test was used to induce scratching bouts. Last, a randomized, double-blind, placebo-controlled trial was conducted to test the efficacy of naloxone in arsenic-exposed patients with pruritus in Shimen.Hair arsenic (μg/g) showed a dose-response relationship with the intensity of itch in 1079 participants, with odds ratios (OR) of 1.11 for moderate-to-severe itch (p = 0.012). The Mendelian randomization analysis confirmed the causal relationship, with ORs of 1.043 for MMA% (p = 0.029) and 0.904 for DMA% (p = 0.077) above versus under median. Serum β-endorphin was identified as a significant biomarker for the intensity of itch (p < 0.001). Consistently, treatment with arsenite upregulated the level of β-endorphin (p = 0.002) and induced scratching bouts (p < 0.001) in mice. The randomized controlled trial in 126 participants showed that treatment with sublingual naloxone significantly relieved the intensity of itch in arsenic-exposed participants in 2 weeks (β = -0.98, p = 0.04).Arsenic exposure is associated with pruritus, and β-endorphin serves as a biomarker of pruritus. Naloxone relieves pruritus in patients with arseniasis.
Selective IgA2 deficiency in a patient with small intestinal Crohn’s disease
Authors: Pablo Canales-Herrerias, Yolanda Garcia-Carmona, Joan Shang, Hadar Meringer, Debra S. Yee, Lin Radigan, Sofija Buta, Gustavo Martinez-Delgado, Michael Tankelevich, Drew Helmus, Marla Dubinsky, Annelie Everts-van der Mind, Thierry Dervieux, Dusan Bogunovic, Jean-Frederic Colombel, Jason M. Brenchley, Jeremiah Faith, Charlotte Cunningham-Rundles, Andrea Cerutti, Saurabh Mehandru
Journal: Journal of Clinical Investigation (2023)

Selective IgA 2 deficiency in a patient with small intestinal Crohn's disease
The role of <i>Drosophila</i> microbiota in gut homeostasis and immunity
Authors: Ghada Tafesh-Edwards, Ioannis Eleftherianos
Journal: Gut Microbes (2023)

The gut epithelia of virtually all animals harbor complex microbial communities that play an important role in maintaining immune and cellular homeostasis. Gut microbiota have evolutionarily adapted to the host gut environment, serving as key regulators of intestinal stem cells to promote a healthy gut barrier and modulate epithelial self-renewal. Disruption of these populations has been associated with inflammatory disorders or cancerous lesions of the intestine. However, the molecular mechanisms controlling gut-microbe interactions are only partially understood due to the high diversity and biologically dynamic nature of these microorganisms. This article reviews the current knowledge on Drosophila gut microbiota and its role in signaling pathways that are crucial for the induction of distinct homeostatic and immune responses. Thanks to the genetic tractability of Drosophila and its cultivable and simple microbiota, this association model offers new efficient tools for investigating the crosstalk between a host and its microbiota while providing a framework for a better understanding of the ecological and evolutionary roles of the microbiome.
Realising the right to health for all people—UHC is the umbrella to deliver health for all
Authors: Maria Fernanda Espinosa, Vytenis Povilas Andriukaitis, Ilona Kickbusch, Sania Nishtar, Emilia Saiz, Keizo Takemi, Gabriela Cuevas Barron, Justin Koonin, Akihito Watabe
Journal: The Lancet Global Health (2023)
REFINE-Lung implements a novel multi-arm randomised trial design to address possible immunotherapy overtreatment
Authors: Ehsan Ghorani, Matteo Quartagno, Fiona Blackhall, Duncan C Gilbert, Mary O'Brien, Christian Ottensmeier, Elena Pizzo, James Spicer, Alex Williams, Philip Badman, Mahesh K B Parmar, Michael J Seckl
Journal: The Lancet Oncology (2023)
Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER): a multicentre, open-label, phase 2 study
Authors: John H Strickler, Andrea Cercek, Salvatore Siena, Thierry André, Kimmie Ng, Eric Van Cutsem, Christina Wu, Andrew S Paulson, Joleen M Hubbard, Andrew L Coveler, Christos Fountzilas, Adel Kardosh, Pashtoon M Kasi, Heinz-Josef Lenz, Kristen K Ciombor, Elena Elez, David L Bajor, Chiara Cremolini, Federico Sanchez, Michael Stecher, Wentao Feng, Tanios S Bekaii-Saab, Eric Van Cutsem, Marc Peeters, Marc Van den Evnde, Thierry André, Christophe Borg, Matthieu Sarabi, Francois Ghiringhelli, Benoist Chibaudel, Salvatore Siena, Chiara Cremolini, Maria G. Zampino, Elena Elez, Susana R. Keranen, Ramon Salazar, Pilar Alfonso, John H. Strickler, Andrea Cercek, Kimmie Ng, Christina Wu, Andrew S. Paulson, Joleen M. Hubbard, Andrew L. Coveler, Christos Fountzilas, Adel Kardosh, Pashtoon M. Kasi, Heinz-Josef Lenz, Kristen K. Ciombor, David L. Bajor, Tanios S. Bekaii-Saab, Olumide Gbolahan, Patrick Boland, Daniel Berg, Federico Sanchez, Timothy Goggins, Anwar Saeed, Howard Burris, Johanna Bendell, Darryl Outlaw, Isaac Tafur, Ardaman Shergill, Daniel Catenacci, Jun Gong, Ignacio Garrido-Laguna, Gene Finley, Benjamin Weinberg, Anthony Shields, Philip Philip, Anita Turk, Anthony Nguyen, Fadi Braiteh, Vijay Patel, William Harwin, Ian Anderson, Ajay Kundra, Christopher Chen, James Ford, Madappa Kundranda, Danny Nguyen, Suresh Ratnam, Donald Richards, Sujatha Nallapareddy, Sridhar Beeram, Scott McKenney, Spencer Shao
Journal: The Lancet Oncology (2023)
Dysregulated Gln-Glu-α-ketoglutarate axis impairs maternal decidualization and increases the risk of recurrent spontaneous miscarriage
Authors: Linchen Tang, Xiang-Hong Xu, Sha Xu, Zeying Liu, Qizhi He, Wenxuan Li, Jiaxue Sun, Wen Shuai, Jingwen Mao, Jian-Yuan Zhao, Liping Jin
Journal: Cell Reports Medicine (2023)

Recurrent spontaneous miscarriage (RSM) affects 1%–2% of fertile women worldwide and poses a risk of future pregnancy complications. Increasing evidence has indicated that defective endometrial stromal decidualization is a potential cause of RSM. Here, we perform liquid chromatography with mass spectrometry (LC-MS)-based metabolite profiling in human endometrial stromal cells (ESCs) and differentiated ESCs (DESCs) and find that accumulated α-ketoglutarate (αKG) derived from activated glutaminolysis contributes to maternal decidualization. Contrarily, ESCs obtained from patients with RSM show glutaminolysis blockade and aberrant decidualization. We further find that enhanced Gln-Glu-αKG flux decreases histone methylation and supports ATP production during decidualization. In vivo, feeding mice a Glu-free diet leads to a reduction of αKG, impaired decidualization, and an increase of fetal loss rate. Isotopic tracing approaches demonstrate Gln-dependent oxidative metabolism as a prevalent direction during decidualization. Our results demonstrate an essential prerequisite of Gln-Glu-αKG flux to regulate maternal decidualization, suggesting αKG supplementation as a putative strategy to rectify deficient decidualization in patients with RSM.
Capabilities and Stakeholders – Two Ways of Enriching the Ethical Debate on Artificial Womb Technology
Authors: André Krom, Angret de Boer, Rosa Geurtzen, Martine C. de Vries
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Email-facilitated qualitative interviews with traumatic brain injury survivors: A new and accessible method Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.
Ethical Aspects of Machine Listening in Healthcare
Authors: Austin M. Stroud, Joel E. Pacyna, Richard R. Sharp
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image size ACKNOWLEDGMENTThe authors thank Journey L. Wise and Jeremiah J. Stout for their help in developing the concept for this editorial and for their feedback on an earlier draft.Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.
The Ethical and Legal Status of ‘Fetonates’ Or ‘Gestatelings’
Authors: Elizabeth Chloe Romanis
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Ethics Considerations Regarding Artificial Womb Technology for the Fetonate Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.
The Dilemmas of Artificial Wombs: Conventional Ethics and Science Fiction
Authors: John D. Lantos, Annie Janvier
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Ethics Considerations Regarding Artificial Womb Technology for the Fetonate Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.
Feminist Concerns About Artificial Womb Technology
Authors: Tamara Kayali Browne, Evie Kendal, Tiia Sudenkaarne
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Ethics Considerations Regarding Artificial Womb Technology for the Fetonate Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.
Differences in Degree-not-Kind-of Responsibility within Conversational Artificial Intelligence
Authors: Kathryn Huber
Journal: The American Journal of Bioethics (2023)

"Differences in Degree-not-Kind-of Responsibility within Conversational Artificial Intelligence." The American Journal of Bioethics, 23(5), pp. 31–32This article refers to:Conversational Artificial Intelligence in Psychotherapy: A New Therapeutic Tool or Agent? Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.
Toward a Broader Conception of Equity in Artificial Womb Technology
Authors: Laura L. Kimberly, Gwendolyn P. Quinn
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Ethics Considerations Regarding Artificial Womb Technology for the Fetonate Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.
The Actionless Agent: An Account of Human-CAI Relationships
Authors: Charles E. Binkley, Bryan Pilkington
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Conversational Artificial Intelligence in Psychotherapy: A New Therapeutic Tool or Agent? Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.
Therapeutic Artificial Intelligence: Does Agential Status Matter?
Authors: Meghan E. Hurley, Benjamin H. Lang, Jared N. Smith
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Conversational Artificial Intelligence in Psychotherapy: A New Therapeutic Tool or Agent? DISCLOSURE STATEMENTNo potential conflict of interest was reported by the author(s).Additional informationFundingThis project was supported from the Agency for Healthcare Research and Quality by grant number R01HS027784. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Agency for Healthcare Research and Quality.
The Postphenomenological Impact of Conversational Artificial Intelligence on Autonomy and Psychological Integrity
Authors: Jordan Joseph Wadden
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Conversational Artificial Intelligence in Psychotherapy: A New Therapeutic Tool or Agent? Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.
Beyond a Medicalized View of Reproduction: Recentering Pregnant People in the Ethics of Ectogenesis
Authors: Nina Roesner
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Ethics Considerations Regarding Artificial Womb Technology for the Fetonate DISCLOSURE STATEMENTThe views expressed are the author?s own and do not represent the position or policy of the National Institutes of Health, the Department of Health and Human Services, or the U.S. government.Additional informationFundingThis work was supported by the National Institutes of Health Intramural Research Program.
Therapists or Replicants? Ethical, Legal, and Social Considerations for Using ChatGPT in Therapy
Authors: Benjamin Amram, Uri Klempner, Shira Shturman, Dov Greenbaum
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Conversational Artificial Intelligence in Psychotherapy: A New Therapeutic Tool or Agent? Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.
Beyond the Domains: What Would be the Fundamental Ethical Questions in the Development of the Artificial Womb
Authors: Montserrat Esquerda, David Lorenzo, Margarita Bofarull
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Ethics Considerations Regarding Artificial Womb Technology for the Fetonate Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.
Thinking Inside the Bag: Patient Selection, Framing the Ethical Discourse, and the Importance of Terminology in Artificial Womb Technology
Authors: Mark R. Mercurio, Kelly M. Werner
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Ethics Considerations Regarding Artificial Womb Technology for the Fetonate Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.
No Substitute: The False Promise of Artificial Womb Technology as an Alternative to Abortion
Authors: Benjamin Patterson Brown, Katie Watson
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Ethics Considerations Regarding Artificial Womb Technology for the Fetonate DISCLOSURE STATEMENTNo potential conflict of interest was reported by the author(s).Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.
Conversational Artificial Intelligence and Distortions of the Psychotherapeutic Frame: Issues of Boundaries, Responsibility, and Industry Interests
Authors: Meghana Kasturi Vagwala, Rachel Asher
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Conversational Artificial Intelligence in Psychotherapy: A New Therapeutic Tool or Agent? Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.
Is the Algorithm Good in a Bad World, or Has It Learned to be Bad? The Ethical Challenges of “Locked” Versus “Continuously Learning” and “Autonomous” Versus “Assistive” AI Tools in Healthcare
Authors: Alaa Youssef, Michael Abramoff, Danton Char
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Conversational Artificial Intelligence in Psychotherapy: A New Therapeutic Tool or Agent? Additional informationFundingFunding for this commentary was provided by Stanford Human-Centered Artificial Intelligence Seed Grant.
Artificial Womb Technology and the Restructuring of Gestational Boundaries
Authors: Richard B Gibson, Lisa Campo-Engelstein
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Ethics Considerations Regarding Artificial Womb Technology for the Fetonate Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.
Staying Curious With Conversational AI in Psychotherapy
Authors: Michael Holohan, Alena Buyx, Amelia Fiske
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Conversational Artificial Intelligence in Psychotherapy: A New Therapeutic Tool or Agent? Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.
Why We Should Understand Conversational AI as a Tool
Authors: Marlies N. van Lingen, Noor A. A. Giesbertz, J. Peter van Tintelen, Karin R. Jongsma
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Conversational Artificial Intelligence in Psychotherapy: A New Therapeutic Tool or Agent? Additional informationFundingFunding was provided by Grant number 104021006 (ZonMW) 2019B012 (Hartstichting).
Conversational Artificial Intelligence and the Potential for Epistemic Injustice
Authors: Michiel De Proost, Giorgia Pozzi
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Conversational Artificial Intelligence in Psychotherapy: A New Therapeutic Tool or Agent? Additional informationFundingMichiel de Proost?s contribution to this work was supported by the H2020 European Research Council (grant number 949841). Giorgia Pozzi's contribution to this work was supported by the European Commission through the H2020-INFRAIA-2018-2020/H2020-INFRAIA-2019-1 European project "SoBigData++: European Integrated Infrastructure for Social Mining and Big Data Analytics" (Grant Agreement 871042). The funders had no role in developing the research and writing the manuscript.
Conversational Artificial Intelligence—Patient Alliance Turing Test and the Search for Authenticity
Authors: Oren Asman, Amir Tal, Yechiel Michael Barilan
Journal: The American Journal of Bioethics (2023)

Click to increase image sizeClick to decrease image sizeThis article refers to:Conversational Artificial Intelligence in Psychotherapy: A New Therapeutic Tool or Agent? Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.