tbuckley/cabot-search huggingface dataset:
Prognostic Prediction of Genotype vs Phenotype in Genetic Cardiomyopathies
Authors: Alessia Paldino, Matteo Dal Ferro, Davide Stolfo, Ilaria Gandin, Kristen Medo, Sharon Graw, Marta Gigli, Giulia Gagno, Denise Zaffalon, Matteo Castrichini, Marco Masè, Antonio Cannatà, Francesca Brun, Garrett Storm, Giovanni Maria Severini, Stefania Lenarduzzi, Giorgia Girotto, Paolo Gasparini, Francesca Bortolotti, Mauro Giacca, Serena Zacchigna, Marco Merlo, Matthew R.G. Taylor, Luisa Mestroni, Gianfranco Sinagra
Journal: Journal of the American College of Cardiology (2022)

Diverse genetic backgrounds often lead to phenotypic heterogeneity in cardiomyopathies (CMPs). Previous genotype-phenotype studies have primarily focused on the analysis of a single phenotype, and the diagnostic and prognostic features of the CMP genotype across different phenotypic expressions remain poorly understood.We sought to define differences in outcome prediction when stratifying patients based on phenotype at presentation compared with genotype in a large cohort of patients with CMPs and positive genetic testing.Dilated cardiomyopathy (DCM), arrhythmogenic right ventricular cardiomyopathy, left-dominant arrhythmogenic cardiomyopathy, and biventricular arrhythmogenic cardiomyopathy were examined in this study. A total of 281 patients (80% DCM) with pathogenic or likely pathogenic variants were included. The primary and secondary outcomes were: 1) all-cause mortality (D)/heart transplant (HT); 2) sudden cardiac death/major ventricular arrhythmias (SCD/MVA); and 3) heart failure-related death (DHF)/HT/left ventricular assist device implantation (LVAD).Survival analysis revealed that SCD/MVA events occurred more frequently in patients without a DCM phenotype and in carriers of DSP, PKP2, LMNA, and FLNC variants. However, after adjustment for age and sex, genotype-based classification, but not phenotype-based classification, was predictive of SCD/MVA. LMNA showed the worst trends in terms of D/HT and DHF/HT/LVAD.Genotypes were associated with significant phenotypic heterogeneity in genetic cardiomyopathies. Nevertheless, in our study, genotypic-based classification showed higher precision in predicting the outcome of patients with CMP than phenotype-based classification. These findings add to our current understanding of inherited CMPs and contribute to the risk stratification of patients with positive genetic testing.
Monoclonal Antibodies for Treatment of SARS-CoV-2 Infection During Pregnancy
Authors: Erin K. McCreary, Lara Lemon, Christina Megli, Amber Oakes, Christopher W. Seymour, Rich Beigi, Maribeth McLaughlin, Hyagriv Simhan, Harold Wiesenfeld, Scarlet Lau, Michael Haley, Sandy Trizzino, Ashley Steiner, Lauren Wiser, Michelle Adam, Tina Borneman, David T. Huang, Richard J. Wadas, Russell Meyers, J. Ryan Bariola, Mark Schmidhofer, Graham Snyder, Donald M. Yealy, Derek C. Angus, Tami Minnier, Judith A. Shovel, Debbie Albin, Oscar C. Marroquin, Kevin Collins, Adam King, Kevin E. Kip, Mary Kay Wisniewski, Colleen Sullivan, Meredith Axe, William Garrard, Stephanie Montgomery, Ghady Haidar, Paula L. Kip, Rachel L. Zapf, Sharen Ziska, Jessica Shirley, Rebecca Medva
Journal: Annals of Internal Medicine (2022)

Monoclonal antibody (mAb) treatment decreases hospitalization and death in high-risk outpatients with mild to moderate COVID-19. However, no studies have evaluated adverse events and effectiveness of mAbs in pregnant persons compared with no mAb treatment.
Coronary Calcium Scoring Improves Risk Prediction in Patients With Suspected Obstructive Coronary Artery Disease
Authors: Simon Winther, Samuel E. Schmidt, Borek Foldyna, Thomas Mayrhofer, Laust D. Rasmussen, Jonathan N. Dahl, Udo Hoffmann, Pamela S. Douglas, Juhani Knuuti, Morten Bøttcher
Journal: Journal of the American College of Cardiology (2022)
lost monarchs
Authors: D.A. Frater
Journal: Annals of Internal Medicine (2022)

Ad LibitumNovember 2022lost monarchsD.A. Frater, MDD.A. Frater, MDE. Barrow Medical Group Dallas, TexasSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M21-4559 Audio Reading - “lost monarchs” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “lost monarchs” by D.A. Frater, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail this fall I sat in quiet wake abovean unclean creek that lured me once from classto stand barefoot like a beakless heronstalking crayfish without fear in its thenclear waters of glass before I was stoppedstood tall by the sight of them Monarchs hundredsfluttering like autumn leaves who've shedtheir sinewy tethers to help us recallnature's unsurpassing beauty to mindan unseen path to their wintering wherenow in the fading clutch of memoryjust a few still find the unquiettrees whose whispers warned of a timewhen the air would be dead and nonewould recall its passing Author, Article, and Disclosure InformationAuthors: D.A. Frater, MDAffiliations: E. Barrow Medical Group Dallas, TexasCorresponding Author: D.A. Frater, MD, E. Barrow Medical Group, 8230 Walnut Hill Lane, Suite 620, Dallas, TX 75231; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “lost monarchs” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “lost monarchs” by D.A. Frater, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics November 2022Volume 175, Issue 11Page: 1616 ePublished: 15 November 2022 Issue Published: November 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Limbic
Authors: Ian P. Wicks
Journal: Annals of Internal Medicine (2022)

Ad LibitumNovember 2022LimbicIan P. Wicks, MB BS, PhDIan P. Wicks, MB BS, PhDWalter & Eliza Hall Institute Melbourne, Victoria, AustraliaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M21-4160 Audio Reading - “Limbic” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Limbic” by Ian P. Wicks, MB BS, PhD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Men make their own history, but they do not make it as they please …— Karl Marx, “The Eighteenth Brumaire of Louis Bonaparte”The smooth sulci and gyri look elegant, imperialbut if we trace that cerebral topographydownward, to the base of the brain,we find a startling collectionof inquilines, gathered togetherin a limbic zone,like barbarians at the gate.Take the amygdalae,almond-shaped nucleihidden, like reptilian eyes,watching for the ancient battlesover food and sex and territory.Or the hippocampus,shaped like a seahorse,beguiling the breast-like mamillary bodiesinto sustaining memory.And the thalami, submerged denizenschanneling a whole world of perception.gifting what ... Author, Article, and Disclosure InformationAuthors: Ian P. Wicks, MB BS, PhDAffiliations: Walter & Eliza Hall Institute Melbourne, Victoria, AustraliaCorresponding Author: Ian P. Wicks, MB BS, PhD; e-mail, [email protected]edu.au. PreviousarticleNextarticle Advertisement Audio Reading - “Limbic” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Limbic” by Ian P. Wicks, MB BS, PhD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics November 2022Volume 175, Issue 11Page: 1621 ePublished: 15 November 2022 Issue Published: November 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Gender and Racial/Ethnic Disparities in Award Distribution by Major Cardiovascular Societies From 2000 to 2021
Authors: Kinza Iqbal, Ashish Kumar, Sawai Singh Rathore, Eisha Farid, Ali Ishaque, Hadiya Afzal, Maha Zahid, Purvi Parwani, Erin D. Michos, Martha Gulati
Journal: Journal of the American College of Cardiology (2022)
A Dubious Discharge
Authors: Paul L. Bernstein
Journal: Annals of Internal Medicine (2022)

On Being a DoctorNovember 2022A Dubious DischargePaul L. Bernstein, MDPaul L. Bernstein, MDYale University, New Haven, ConnecticutSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M22-2108 Audio Reading - “A Dubious Discharge” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “A Dubious Discharge” by Paul L. Bernstein Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “We want to talk to you about next steps,” the anxious intern explained as the team formed a semicircle around Mr. Chubb on morning rounds. The patient was seated. The intern was not. The intern's rumpled scrubs pulled in all the wrong places. Mr. Chubb, hands folded in his lap, unclasped and opened them, thumbs out in a sign of acceptance. A slow nod of his head invited the intern to continue.While we listened, I replayed the days of his admission. He was admitted through the ICU and step-down unit; his alcohol binge in the midst of winter had ... Author, Article, and Disclosure InformationAuthors: Paul L. Bernstein, MDAffiliations: Yale University, New Haven, ConnecticutCorresponding Author: Paul L. Bernstein, MD; e-mail, paul.[email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “A Dubious Discharge” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “A Dubious Discharge” by Paul L. Bernstein Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics November 2022Volume 175, Issue 11Page: 1614 ePublished: 15 November 2022 Issue Published: November 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
How Do Implicit Bias and Stereotype Threat Affect Mental Health Care for a Student of Color?
Authors: Chukwuemeka N. Uwakaneme
Journal: Annals of Internal Medicine (2022)

On Being a PatientNovember 2022How Do Implicit Bias and Stereotype Threat Affect Mental Health Care for a Student of Color?Chukwuemeka N. Uwakaneme, BAChukwuemeka N. Uwakaneme, BAVirginia Tech Carilion School of Medicine, Roanoke, VirginiaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M22-0934 Audio Reading - “How Do Implicit Bias and Stereotype Threat Affect Mental Health Care for a Student of Color?” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “How Do Implicit Bias and Stereotype Threat Affect Mental Health Care for a Student of Color?” by Chukwuemeka N. Uwakaneme, BA Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The other day, I was listening to a popular storytelling and journalism podcast called This American Life, which bases its episodes on themes. This episode's theme dealt with people being on television when they didn't necessarily want to be.In the episode, a television crew for the show Cops is filming a traffic stop. The police officer approaches two silent teenagers and asks to search their car. They agree immediately, although you can't really hear them. The officer finds what he believes to be crack cocaine in the back seat and does what they call a Narcotics Identification Kit test. ... Author, Article, and Disclosure InformationAuthors: Chukwuemeka N. Uwakaneme, BAAffiliations: Virginia Tech Carilion School of Medicine, Roanoke, VirginiaCorresponding Author: Chukwuemeka N. Uwakaneme, BA, 2 Riverside Circle, Roanoke, VA, 24016; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “How Do Implicit Bias and Stereotype Threat Affect Mental Health Care for a Student of Color?” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “How Do Implicit Bias and Stereotype Threat Affect Mental Health Care for a Student of Color?” by Chukwuemeka N. Uwakaneme, BA Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics November 2022Volume 175, Issue 11Page: 1619-1620 ePublished: 15 November 2022 Issue Published: November 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Total Ankle Replacement Versus Arthrodesis for End-Stage Ankle Osteoarthritis
Authors: Andrew J. Goldberg, Kashfia Chowdhury, Ekaterina Bordea, Iva Hauptmannova, James Blackstone, Deirdre Brooking, Elizabeth L. Deane, Stephen Bendall, Andrew Bing, Chris Blundell, Sunil Dhar, Andrew Molloy, Steve Milner, Mike Karski, Steve Hepple, Malik Siddique, David T. Loveday, Viren Mishra, Paul Cooke, Paul Halliwell, David Townshend, Simon S. Skene, Caroline J. Doré
Journal: Annals of Internal Medicine (2022)

Background: End-stage ankle osteoarthritis causes severe pain and disability. There are no randomized trials comparing the 2 main surgical treatments: total ankle replacement (TAR) and ankle fusion (AF). Objective: To determine which treatment is superior in terms of clinical scores and adverse events. Design: A multicenter, parallel-group, open-label randomized trial. (ISRCTN registry number: 60672307) Setting: 17 National Health Service trusts across the United Kingdom. Patients: Patients with end-stage ankle osteoarthritis, aged 50 to 85 years, and suitable for either procedure. Intervention: Patients were randomly assigned to TAR or AF surgical treatment. Measurements: The primary outcome was change in Manchester–Oxford Foot Questionnaire walking/standing (MOXFQ-W/S) domain scores between baseline and 52 weeks after surgery. No blinding was possible. Results: Between 6 March 2015 and 10 January 2019, a total of 303 patients were randomly assigned; mean age was 68 years, and 71% were men. Twenty-one patients withdrew before surgery, and 281 clinical scores were analyzed. At 52 weeks, the mean MOXFQ-W/S scores improved for both groups. The adjusted difference in the change in MOXFQ-W/S scores from baseline was −5.6 (95% CI, −12.5 to 1.4), showing that TAR improved more than AF, but the difference was not considered clinically or statistically significant. The number of adverse events was similar between groups (109 vs. 104), but there were more wound healing issues in the TAR group and more thromboembolic events and nonunion in the AF group. The symptomatic nonunion rate for AF was 7%. A post hoc analysis suggested superiority of fixed-bearing TAR over AF (−11.1 [CI, −19.3 to −2.9]). Limitation: Only 52-week data; pragmatic design creates heterogeneity of implants and surgical techniques. Conclusion: Both TAR and AF improve MOXFQ-W/S and had similar clinical scores and number of harms. Total ankle replacement had greater wound healing complications and nerve injuries, whereas AF had greater thromboembolism and nonunion, with a symptomatic nonunion rate of 7%. Primary Funding Source: National Institute for Health and Care Research Heath Technology Assessment Programme.
Changes in Health Care Spending, Use, and Clinical Outcomes After Nonfatal Firearm Injuries Among Survivors and Family Members
Authors: Alan R. Ertle
Journal: Annals of Internal Medicine (2022)

LettersNovember 2022Changes in Health Care Spending, Use, and Clinical Outcomes After Nonfatal Firearm Injuries Among Survivors and Family MembersAlan R. Ertle, MD, MPH, MBAAlan R. Ertle, MD, MPH, MBAEmeritus Enterprises, Klamath Falls, OregonSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L22-0266 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR: I read Song and colleagues' article (1) with interest. It is not surprising that medical costs, psychiatric disorders, substance use disorders, and pain increase after someone survives a nonfatal firearm injury. The same would probably occur in survivors of automobile crash, sporting, and workplace injuries. However, the extent to which the costs and other issues associated with these injuries increase compared with firearm injuries is unclear. Approximately 1.5 million automobile crashes with survivors with injuries take place each year in the United States. If the cost increases for these survivors were the same as for survivors of ...References1. Song Z, Zubizarreta JR, Giuriato M, et al. Changes in health care spending, use, and clinical outcomes after nonfatal firearm injuries among survivors and family members. A cohort study. Ann Intern Med. 2022;175:795-803. [PMID: 35377713] doi:10.7326/M21-2812 LinkGoogle Scholar2. National Highway Traffic Safety Administration. Traffic safety facts annual report tables. 2022. Accessed at https://cdan.nhtsa.gov/tsftables/tsfar.htm# on 4 April 2022. Google Scholar Author, Article, and Disclosure InformationAffiliations: Emeritus Enterprises, Klamath Falls, OregonDisclosures: Authors have reported no disclosures of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L22-0266. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoChanges in Health Care Spending, Use, and Clinical Outcomes After Nonfatal Firearm Injuries Among Survivors and Family Members Zirui Song , José R. Zubizarreta , Mia Giuriato , Erica Paulos , and Katherine A. Koh Metrics November 2022Volume 175, Issue 11Page: W145KeywordsConflicts of interestFirearm injuriesHealth careHealth care policyMorbidityPsychiatry and mental healthSurvival analysis ePublished: 15 November 2022 Issue Published: November 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Late in the Afternoon
Authors: Richard Scott Morehead
Journal: Annals of Internal Medicine (2022)

On Being a DoctorNovember 2022Late in the AfternoonRichard Scott Morehead, MDRichard Scott Morehead, MDWest Virginia University—Charleston Division and Charleston Area Medical Center, Charleston, West VirginiaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M22-1264 Audio Reading - “Late in the Afternoon” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Late in the Afternoon” by Richard Scott Morehead, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail With fondness I recall that as a young boy, my grandfather took me fishing. Early Saturday mornings he would lash cane poles to his car and drive us to the freshwater canals bordering the Florida Everglades, where we used worms to catch panfish. It was better than Christmas morning. Forever etched in my mind is his image: an active, older man in dark suit clothes showing me how to read water, bait a hook, and interpret the cork bobber. I now recognize that his goal was my success, and his intent was no different on Sunday mornings when he stood ... Author, Article, and Disclosure InformationAuthors: Richard Scott Morehead, MDAffiliations: West Virginia University—Charleston Division and Charleston Area Medical Center, Charleston, West VirginiaCorresponding Author: Richard Scott Morehead, MD, 1 Wildacre Road, Charleston, WV 25314; e-mail, [email protected]wvu.edu. PreviousarticleNextarticle Advertisement Audio Reading - “Late in the Afternoon” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Late in the Afternoon” by Richard Scott Morehead, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics November 2022Volume 175, Issue 11Page: 1615-1616 ePublished: 15 November 2022 Issue Published: November 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...