tbuckley/cabot-search huggingface dataset:
Diseases of the Eye, and Ophthalmology.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A social worker speaks.
Authors: Mr Dewsbery, Mr Blake
Journal: BMJ (1974)

Accidental Tattooing Grazes and cuts due to falls on roads, gravel, or coal may heal with the retention of particles or dirt in the scar and the dermis, resulting in unisightly itattooing.This can be preven- ted if ithe wound is adequately cleaned initially, and it may be necessary to scrub the wound with a scrubbing brush under a general anaesthetic.Once a tattooed wound has healed improvement can only be achieved by excising the scar or by dermabrading the more superficial pigment.
Development of an international core outcome set for peripheral vascular malformations: the OVAMA project
Authors: S.E.R. Horbach, C.M.A.M. van der Horst, F. Blei, C.J.M. van der Vleuten, I. J. Frieden, G.T. Richter, S.T. Tan, T. Muir, A.J. Penington, L.M. Boon, P.I. Spuls
Journal: British Journal of Dermatology (2018)

Peripheral vascular malformations (VMs) are birthmarks or swellings caused by the faulty development of blood vessels in the embryo. Different types are classified according to whether the components are mainly lymph vessels (LMs), veins (VMs) or combined arteries and veins (AVMs). It is hard to assess the various medical and surgical treatments available because there are no agreed methods for measuring the outcome. This international group carried out an on‐line survey of health professionals and patients to decide which factors would be important to record in future clinical trials. First they listed aspects of the condition and its treatment in 36 domains covering 97 specific items. Then they asked 167 doctors and 134 patients and parents of patients to score the domains from 0 (not important) to 4 (crucial). The options were progressively narrowed down over 3 rounds of the survey and a consensus conference. The finally agreed “core outcome set” covered: scan results, doctors’ assessment of problems caused by pressure from the VM, patient or parent's assessments of symptoms, pain and quality of life, and their satisfaction with the treatment, outcome and any adverse effects. Additional specific factors for LMs were infections and lymphatic fluid leakage, for VMs thrombosis and for AVMs heart function and bleeding. Recurrence after treatment and appearance were also recommended for inclusion. This international consensus establishes what factors should be assessed in future trials of treatments for vascular malformations, but further work is required to decide exactly how they should be measured and reported.
Wordy Resolutions
Authors: John Murray
Journal: New England Journal of Medicine (1969)

The beginning of a new year not only marks the apogee of the annual cycle of good intentions but also is the occasion for a backward glance at what was intented but not accomplished. Like others, medical-journal editors engage in such polar surveys, but their panoramas are structured of grand and abstract issues. At least, so one would gather from the current Lancet series, "The Editor Speaks," for in these articles he speaks of communication, of teaching and of the energy of free discussion. Yet everyone knows full well that in the privacy of its cubicle, the blue pencil scratches . . .
Low-density lipoprotein subclass patterns and risk of myocardial infarction
Authors: M. A. Austin
Journal: JAMA (1988)

The association of low-density lipoprotein (LDL) subclass patterns with coronary heart disease was investigated in a case-control study of nonfatal myocardial infarction. Subclasses of LDL were analyzed by gradient gel electrophoresis of plasma samples from 109 cases and 121 controls. The LDL subclass pattern characterized by a preponderance of small, dense LDL particles was significantly associated with a threefold increased risk of myocardial infarction, independent of age, sex, and relative weight. Plasma levels of high-density lipoprotein cholesterol were decreased, and levels of triglyceride, very low—density lipoproteins, and intermediate-density lipoproteins were increased in subjects with this LDL subclass pattern. Multivariate logistic regression analyses showed that both high-density lipoprotein cholesterol and triglyceride levels contributed to the risk associated with the small, dense LDL subclass pattern. Thus, the metabolic trait responsible for this LDL subclass pattern results in a set of interrelated lipoprotein changes that lead to increased risk of coronary heart disease. (<i>JAMA</i>1988;260:1917-1921)
Physician DRGs
Authors: Janet B. Mitchell
Journal: New England Journal of Medicine (1985)

DRG-based reimbursement for inpatient services is an option currently being considered by federal policy makers, but little is known about how physician DRGs might work. We performed simulations of potential impacts, using Medicare claims from four states. Although physician-related inpatient costs associated with surgical DRGs were quite homogeneous, those associated with medical admissions varied dramatically. This suggests that DRG payment could be a lottery, with inequitable losses for some physicians and windfall gains for others. Potential gains and losses were also found to be systematically related to the specialty of the attending physician. General practitioners and ophthalmologists would gain financially on average, whereas medical specialists and some surgical specialists would incur net losses. These differences may be due to the triaging of more seriously ill patients within a given DRG to certain specialists. (N Engl J Med 1985; 313:670–5.)
Family Study of Hysteria
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quality Health Care
Authors: Linda A. Headrick
Journal: JAMA (1995)

Health professionals are reporting progress in the application of improvement principles and methods to clinical care. One year ago we wrote, "Continuous improvement is a reality in clinical medicine.... Examples of improvement in direct patient care finally have emerged in the literature."<sup>1</sup>The pace is increasing. A recent MEDLINE search of the entries "total quality management" combined with "clinical" from 1985 to 1994 revealed 125 English-language citations, with 91 written from 1991 through 1994. A similar search of the entries "continuous quality improvement" combined with "clinical" uncovered 82 articles, all but 15 published after 1991. The most successful efforts combine professional knowledge (such as pathogenesis and therapeutics) with "knowledge for improvement," as described by Batalden and Nolan<sup>2</sup>and elaborated on by Batalden and Stoltz.<sup>3</sup>Knowledge for improvement incorporates an understanding of systems, statistical variation, the psychology of work and change, and the scientific method. We will focus
EVANGELIST D. L. MOODY ON PHYSICIANS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allied Health Education and Accreditation
Authors: Hannah L. Hedrick
Journal: JAMA (1982)

<h3>COOPERATION AMONG THE HEALTH PROFESSIONS</h3> For the past 50 years, the American Medical Association has remained committed to extensive participation in the complex allied health education and accreditation processes. In collaboration with more than 40 medical specialty societies and allied health organizations, the AMA has cooperated in the development of educational standards for 26 allied health professions (Appendix IV, Table 2), for which the Committee on Allied Health Education and Accreditation (CAHEA) accredits more than 3,000 allied health educational programs (Appendix IV, Table 1 and Fig 1A) at almost 1,800 institutions, including hospitals and clinics, junior/community colleges, colleges and universities, and other institutions (Appendix IV, Fig 1B). Central to the development of allied health educational programs are the educational standards, referred to as<i>Essentials</i>. The collaborating organizations cooperate with the AMA in developing and adopting<i>Essentials</i>. In December 1976, the AMA House of Delegates delegated its responsibility for reviewing and
SLOWNESS OF PERCEPTION OF SIGNALS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Author Name
Journal: JAMA Pediatrics (2018)

Alisa Khan, MD, MPH; Maitreya Coffey, MD, FRCPC; Katherine P. Litterer, BA; Jennifer D. Baird, PhD, MSW, RN; Stephannie L. Furtak, BA; Briana M. Garcia, BS; Michele A. Ashland, BA; Sharon Calaman, MD; Nicholas C. Kuzma, MD; Jennifer K. O’Toole, MD, MEd; Aarti Patel, MD, MEd; Glenn Rosenbluth, MD; Lauren A. Destino, MD; Jennifer L. Everhart, MD; Brian P. Good, MB BCh BAO; Jennifer H. Hepps, MD; Anuj K. Dalal, MD; Stuart R. Lipsitz, ScD; Catherine S. Yoon, MS; Katherine R. Zigmont, BSN, RN; Rajendu Srivastava, MD, FRCPC, MPH; Amy J. Starmer, MD, MPH; Theodore C. Sectish, MD; Nancy D. Spector, MD; Daniel C. West, MD; Christopher P. Landrigan, MD, MPH; and the Patient and Family Centered I-PASS Study Group; Brenda K. Allair, BA, MEd; Claire Alminde, MSN, RN; Wilma Alvarado-Little, MA, MSW; Marisa Atsatt, MS; Megan E. Aylor, MD; James F. Bale Jr, MD; Dorene Balmer, PhD; Kevin T. Barton, MD; Carolyn Beck, MD, FRCPC; Zia Bismilla, MD, FRCPC, MEd; Rebecca L. Blankenburg, MD, MPH; Debra Chandler, RN; Amanda Choudhary, MHA; Eileen Christensen, BA; Sally Coghlan-McDonald, JD; F. Sessions Cole, MD; Elizabeth Corless, RN; Sharon Cray, BBA; Roxi Da Silva, MSN, RN; Devesh Dahale, BS, MSc; Benard Dreyer, MD; Amanda S. Growdon, MD; LeAnn Gubler, RN; Amy Guiot, MD, MEd; Roben Harris; Helen Haskell, MA; Irene Kocolas, MD, MS; Elizabeth Kruvand, BS; Michele Marie Lane, RN; Kathleen Langrish, RN, MN; Christy J. W. Ledford, PhD; Kheyandra Lewis, MD; Joseph O. Lopreiato, MD, MPH; Christopher G. Maloney, MD, PhD; Amanda Mangan, RN; Peggy Markle, BA; Fernando Mendoza, MD; Dale Ann Micalizzi, AAS; Vineeta Mittal, MD, MBA; Maria Obermeyer, RN; Katherine A. O’Donnell, MD; Mary Ottolini, MD, MPH; Shilpa J. Patel, MD; Rita Pickler, PhD, RN; Jayne Elizabeth Rogers, MSN, RN, NEA-BC; Lee M. Sanders, MD; Kimberly Sauder, RN; Samir S. Shah, MD, MSCE; Meesha Sharma, MD, MPH; Arabella Simpkin, BMBCh, MMSc; Anupama Subramony, MD, MBA; E. Douglas Thompson Jr, MD; Laura Trueman, RN; Tanner Trujillo, MHA; Michael P. Turmelle, MD; Cindy Warnick, BS; Chelsea Welch, BS; Andrew J. White, MD; Matthew F. Wien, BS; Ariel S. Winn, MD; Stephanie Wintch, RN; Michael Wolf, PhD, MPH; H. Shonna Yin, MD, MS; Clifton E. Yu, MD
The Pathology of Internal Diseases.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Introduction to Statistics
Authors: J. Knowelden
Journal: BMJ (1952)

<h3>Background</h3> People with osteoarthritis (OA) can experience both nociceptive pain, as a result of local joint damage, and pain that is indicative of abnormal central pain processing. Quantitative sensory testing (QST) is psychophysical testing of somatosensory function and can been used to investigate somatosensory abnormalities in people with OA. <h3>Objectives</h3> The aim of this study was to assess the reliability discriminant ability of two different mechanical stimuli for QST measurements, pressure and punctate, in people with knee OA and healthy participants. <h3>Methods</h3> Twenty six knee OA participants and 25 healthy participants were recruited. QST was performed in all participants at three sites on the body (sternum, index knee and anterior tibia). Two mechanical QST modalities (pressure and punctate) were performed. Pressure pain threshold (PPT) was assessed using digital algometry. Punctate QST measurements, {mechanical pain threshold (MPT), mechanical pain sensitivity (MPS) and wind-up ratio (WUR)}, were assessed using pinprick stimulators. The procedures were repeated during a second assessment four weeks later by the same examiner to determine repeatability. All participants completed the Intermittent and Constant Osteoarthritis Pain (ICOAP) questionnaire (Rasch transformed). <h3>Results</h3> The mean age for OA participants was 66 years (standard deviation (SD) (9), (50% female) and for the healthy participants was 58 years (SD 11), (48% female). People with knee OA demonstrated significantly higher values on ICOAP Rasch transformed; Intermittent {mean 7.13 (4.47) and Constant mean 4.40 (4.47)} than healthy participants; Intermittent {mean 1.12 (2.31) and Constant {mean 0.29 (1.03)} (<i>P</i>&lt;0.001). The test-retest reliability of the QST measurements before and after 4 weeks interval expressed as intraclass correlation coefficients (ICCs) are given in Table 1. People with knee OA had significantly lower PPT at knee and tibia than normal controls (Graph). Differences between OA and control groups remained significant after adjustment for age and sex. Whereas there were no significant differences found in any punctate QST measurements between knee OA and healthy participants. <h3>Conclusions</h3> This study demonstrated that PPT is a reliable QST measurement with less variability compared to other mechanical QST measurements assessed. PPT at the tibia, a site distal to the affected joint, is believed to reflect augmented central pain processing. PPT may be a preferred QST modality to investigate altered central pain processing in people with OA. <h3>References</h3> R. Rolke et al. Pain 123 (2006), 231 – 243. A.K. Suokas et al. Osteoarthritis Cartilage 10 (2012), 1075–1085 V. Wylde et al. Osteoarthritis Cartilage 19 (2011), 655–658 M Pigg et al. Pain 148 (2010), 220 – 226. <h3>Disclosure of Interest</h3> None declared
PATH-15. IDENTIFICATION OF SUBSETS OF IDH-MUTANT GLIOBLASTOMAS WITH DISTINCT EPIGENETIC AND COPY NUMBER ALTERATIONS AND STRATIFIED CLINICAL RISKS
Authors: Kay Ka-Wai Li, Hong Chen, Houtan Noushmehr, Ho-Keung Ng
Journal: Neuro-Oncology (2019)

Abstract IDH-mutant glioblastoma is classified by the 2016 CNS WHO as a group with good prognosis. However, the actual number of cases examined in the literature is relatively small. We hypothesize that IDH-mutant glioblastoma is not a uniform group and should be further stratified. We conducted methylation profiles and estimated copy number variations of 57 IDH-mutant glioblastomas. Our results showed that 59.6%, and 40.4% of tumors belonged to G-CIMP-high and G-CIMP-low methylation subgroups, respectively. G-CIMP-low subgroup was associated with significantly worse OS as compared to G-CIMP-high (P=0.005). CDKN2A deletion (42.1%) was the most common gene copy number variation, and was significantly associated with G-CIMP-low subgroup (P=0.004). Other frequent copy number changes included MET (5.3%), CCND2 (19.3%), PDGFRA (14.0%), CDK4 (12.3%), and EGFR (12.3%) amplification. Both CDKN2A deletion (P=0.036) and MET amplification (P&lt; 0.001) were associated with poor OS in IDH-mutant glioblastomas. Combined epigenetic signatures and gene copy number variations separated IDH-mutant glioblastomas into Group 1 (G-CIMP-high), Group 2 (G-CIMP-low without CDKN2A nor MET alterations), and Group 3 (G-CIMP-low with CDKN2A and/or MET alterations). Survival analysis revealed Groups 1 and 2 exhibited a favorable OS (median survival: 619 days (20.6 months), and 655 days (21.8 months), respectively). Group 3 exhibited a significant shorter OS (median survival: 252 days (8.4 months)). Multivariable analysis confirmed the independent prognostic significance of our Groups. IDH-mutant glioblastomas should be stratified for risk with combined epigenetic signature and CDKN2A/MET status and some cases have poor outcome.
Abstract 13709: High-Density Lipoprotein is a Novel Activator of Cardiac Glucose Metabolism in both Healthy and Insulin Resistant Myocardium
Authors: Sarah E Heywood, Darren C Henstridge, Adele L Richart, Karen Alt, Andrew L Carey, Helene L Kammoun, Lea M Delbridge, Christoph E Hagemeyer, Mark A Febbraio, Bronwyn A Kingwell, Andrew L Siebel
Journal: Circulation (2015)

Aims: High-density lipoprotein (HDL) is known to increase skeletal muscle glucose uptake, but whether this action extends to the myocardium and has relevance in the setting of ischemia is unknown. This study aimed to determine the effect of HDL on cardiac glucose metabolism both in vitro and in vivo, including during ischemia/reperfusion injury. Methods and Results: HDL treatment (50μg/mL) increased glucose uptake (147±10%), glycolysis (154±11%) and glucose oxidation (130±6%) in neonatal ventricular cardiomyocytes compared to saline control. HDL rapidly activated the Akt pathway and an Akt inhibitor (Akti 1/2) abolished HDL-mediated glucose uptake, suggesting an Akt-dependent mechanism. To determine the upstream receptor mechanism HDL binding to sphingosine-1-phosphate (S1P) receptors was blocked with either 1uM VPC23019 (S1P1&amp;3 antagonist) or 1uM CAY10444 (S1P3 antagonist). Both similarly inhibited HDL-mediated glucose uptake. S1P is a known activator of the Akt pathway, thus our data suggests the S1P component of HDL increases glucose uptake via S1P3 activation of the Akt pathway. The effect of a single intravenous bolus of reconstituted HDL (CSL-111; 80mg/kg) in chow diet (CD) and high fat diet (HFD) insulin resistant C57Bl6 mice was investigated during an oral glucose tolerance test (OGTT). CSL-111 treatment increased cardiac muscle glucose clearance in both CD (168±16%) and HFD (138±11%) mice compared to saline infusion during the OGTT. To assess whether CSL-111 could increase cardiac glucose uptake in an ischemic setting, a single bolus of CSL-111 (80mg/kg) was given at the beginning of reperfusion in mice following left anterior descending artery (LAD) ligation. CSL-111 trended to increase cardiac glucose uptake ([18F]Fluorodeoxyglucose tracer and PET-CT imaging) by 66% (chow) and 81% (HFD) (treatment effect p=0.07) 1 hour post-reperfusion following LAD surgery. Furthermore, CSL-111 improved long term cardiac functional recovery. Conclusion: These data show that HDL increases glucose uptake and utilisation in the heart suggesting a role for HDL therapies in preserving functional myocardium subsequent to acute coronary ischemic syndromes.