tbuckley/cabot-search huggingface dataset:
DNA Damage and Nuclear Morphological Changes in Cardiac Hypertrophy Are Mediated by SNRK Through Actin Depolymerization
Authors: Paulina J. Stanczyk, Yuki Tatekoshi, Jason S. Shapiro, Krithika Nayudu, Yihan Chen, Zachary Zilber, Matthew Schipma, Adam De Jesus, Amir Mahmoodzadeh, Ashley Akrami, Hsiang-Chun Chang, Hossein Ardehali
Journal: Circulation (2023)

Proper nuclear organization is critical for cardiomyocyte function, because global structural remodeling of nuclear morphology and chromatin structure underpins the development and progression of cardiovascular disease. Previous reports have implicated a role for DNA damage in cardiac hypertrophy; however, the mechanism for this process is not well delineated. AMPK (AMP-activated protein kinase) family of proteins regulates metabolism and DNA damage response (DDR). Here, we examine whether a member of this family, SNRK (SNF1-related kinase), which plays a role in cardiac metabolism, is also involved in hypertrophic remodeling through changes in DDR and structural properties of the nucleus.
Housing Mobility Intervention for Childhood Asthma
Authors: Shen Ko, Nin-Chieh Hsu
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparative efficacy on outcomes of C-CABG, OPCAB, and ONBEAT in coronary heart disease: a systematic review and network meta-analysis of randomized controlled trials
Authors: Lin Zhu, Dongjie Li, Xu Zhang, Sitong Wan, Yuyong Liu, HongJia Zhang, Junjie Luo, Yongting Luo, Peng An, Wenjian Jiang
Journal: International Journal of Surgery (2023)

Coronary artery bypass grafting (CABG) remains the gold standard for the treatment of multivessel and left main coronary heart disease. However, the current evidence about the optimal surgical revascularization strategy is inconsistent and is not sufficient to allow for definite conclusions. Thus, this topic needs to be extensively discussed.
Comparison of safety and effectiveness between robotic and laparoscopic major hepatectomy: a systematic review and meta-analysis
Authors: Benliang Mao, Shanfei Zhu, Dan Li, Junhao Xiao, Bailin Wang, Yong Yan
Journal: International Journal of Surgery (2023)

Robotic platform has been increasingly applied in major hepatectomy. However, the role or advantage of robotic approach comparing with laparoscopic approach in major hepatectomy remains controversial. This meta-analysis compares perioperative outcomes of robotic major hepatectomy (RMH) to laparoscopic major hepatectomy (LMH) for hepatic neoplasms.
Deep learning using computed tomography to identify high-risk patients for acute small bowel obstruction: development and validation of a prediction model : a retrospective cohort study
Authors: Seungmin Oh, Jongbin Ryu, Ho-Jung Shin, Jeong Ho Song, Sang-Yong Son, Hoon Hur, Sang-Uk Han
Journal: International Journal of Surgery (2023)

Objective: To build a novel classifier using an optimized 3D-convolutional neural network for predicting high-grade small bowel obstruction (SBO). Summary Background Data: Acute SBO (ASBO) is one of the most common acute abdominal diseases requiring urgent surgery. While AI and abdominal CT have been used to determine surgical treatment, differentiating normal cases, high-grade small bowel obstruction (HGSBO) requiring emergency surgery, and low-grade SBO or paralytic ileus (LGSBO) is difficult. Methods: A deep learning classifier was used to predict high-risk ASBO patients using CT images at a tertiary hospital. Images from three groups of subjects (normal, nonsurgical, and surgical) were extracted; the dataset used in the study included 578 cases from 250 normal subjects, with 209 HGSBO and 119 LGSBO patients; over 38,000 CT images were used. Data were analyzed from June 1, 2022, to February 5, 2023. The classification performance was assessed based on accuracy, sensitivity, specificity, and area under the receiver operating characteristic curve. Results: After 5-fold cross-validation, the WideResNet classifier using dual-branch architecture (DBA) with depth retention pooling (DRP) achieved an accuracy of 72.6%, an area under receiver operating characteristic of 0.90, a sensitivity of 72.6%, a specificity of 86.3%, a positive predictive value of 74.1%, and a negative predictive value of 86.6% on all the test sets. Conclusions: These results show the satisfactory performance of the deep learning classifier in predicting HGSBO compared to the previous machine learning model. The novel 3D classifier with DBA and DRP based on AI algorithms could be a reliable screening and decision-support tool for high-risk patients with SBO.
Care Ecosystem Collaborative Model and Health Care Costs in Medicare Beneficiaries With Dementia
Authors: Elan L. Guterman, Rachel E. Kiekhofer, Andrew J. Wood, I. Elaine Allen, James G. Kahn, Sarah Dulaney, Jennifer J. Merrilees, Kirby Lee, Winston Chiong, Stephen J. Bonasera, Tamara L. Braley, Lauren J. Hunt, Krista L. Harrison, Bruce L. Miller, Katherine L. Possin
Journal: JAMA Internal Medicine (2023)

Collaborative dementia care programs are effective in addressing the needs of patients with dementia and their caregivers. However, attempts to consider effects on health care spending have been limited, leaving a critical gap in the conversation around value-based dementia care.
Long-term outcomes of microsurgery and stereotactic radiosurgery as the first-line treatment for arteriovenous malformations: a propensity score-matched analysis using nationwide multicenter prospective registry data
Authors: Heze Han, Dezhi Gao, Li Ma, Ruinan Li, Zhipeng Li, Haibin Zhang, Kexin Yuan, Ke Wang, Yukun Zhang, Yang Zhao, Weitao Jin, Hengwei Jin, Xiangyu Meng, Debin Yan, Runting Li, Fa Lin, Qiang Hao, Hao Wang, Xun Ye, Shuai Kang, Jun Pu, Zhiyong Shi, Xiaofeng Chao, Zhengfeng Lin, Junlin Lu, Youxiang Li, Yuanli Zhao, Shibin Sun, Yu Chen, Xiaolin Chen, Shuo Wang
Journal: International Journal of Surgery (2023)

Background: This study aimed to compare the risk and benefit profile of microsurgery (MS) and stereotactic radiosurgery (SRS) as the first-line treatment for unruptured and ruptured arteriovenous malformations (AVMs). Materials and Methods: We included AVMs underwent MS or SRS as the first-line treatment from a nationwide prospective multicenter registry in *BLINDED*. We used propensity score-matched methods to balance baseline characteristics between MS and SRS groups. The primary outcomes were long-term hemorrhagic stroke or death, and the secondary outcomes were long-term obliteration and neurological outcomes. Subgroup analyses and sensitivity analyses with different study designs were performed to confirm the stability of our findings. Results: Of 4286 consecutive AVMs in the registry from 2011.08 to 2021.12, 1604 patients were eligible. After matching, 244 unruptured and 442 ruptured AVMs remained for the final analysis. The mean follow-up duration was 7.0 years in the unruptured group and 6.1 years in the ruptured group. In the comparison of primary outcomes, SRS was associated with a higher risk of hemorrhagic stroke or death both in the unruptured and ruptured AVMs (unruptured: hazard ratio [HR] 4.06, 95%confidence interval [CI] 1.15-14.41; ruptured: HR 4.19, 95%CI 1.58-11.15). In terms of the secondary outcomes, SRS was also observed to have a significant disadvantage in long-term obliteration (unruptured: odds ratio [OR] 0.01, 95%CI 0.00-0.04; ruptured: OR 0.09, 95%CI 0.05-0.15). However, it should be noted that SRS may have advantages in preventing neurofunctional decline (unruptured: OR 0.56, 95%CI 0.27-1.14; ruptured: OR 0.41, 95%CI 0.23-0.76). Results of subgroup analyses and sensitivity analyses were consistent in trend but with slightly varied powers. Conclusions: This clinical practice-based real-world study comprehensively compared MS and SRS for AVMs with long-term outcomes. MS is more effective in preventing future hemorrhage or death and achieving obliteration, while the risk of neurofunctional decline should not be ignored.
Laparoscopic natural orifice specimen extraction (NOSE) colectomy versus conventional laparoscopic colorectal resection in patients with rectal endometriosis: a randomized, controlled trial
Authors: Noémi Dobó, Gabriella Márki, Gernot Hudelist, Noémi Csibi, Réka Brubel, Nándor Ács, Attila Bokor
Journal: International Journal of Surgery (2023)

Background: The conventional laparoscopic approach for the surgical management of deep endometriosis (DE) infiltrating the rectum appears to ensure improved digestive functional outcomes. The natural orifice specimen extraction (NOSE) technique for the treatment of colorectal DE can significantly accelerate postoperative recovery; however, data on gastrointestinal function following conventional laparoscopic segmental bowel resection (CLR) compared with NOSE-colectomy (NC) for DE are sparse. Materials and methods: Between September 30, 2019, and December 31, 2020, a randomized, open-label, two-arm, parallel-group controlled trial with women aged 18–45 years was conducted at University Hospital. 91 patients were randomized to CLR or NC, with DE infiltrating at least the muscular layer, at least 50% of the circumference of the bowel, up to 15 cm from the anal verge, exhibiting pain and bowel symptoms and/or infertility. The primary endpoint was bowel function, represented by Low Anterior Resection Syndrome (LARS). Secondary parameters included the Endometriosis Health Profile 30 (EHP30), Gastrointestinal Quality of Life Index (GIQLI), Visual Analog Scale (VAS) scores preoperatively and at set times (one and six months, one year) following surgery. Results: No significant differences were observed in the postoperative LARS scores, VAS, EHP30, and GIQLI between the NC and CLR groups. LARS scores did not reveal significant differences 12 months postoperatively compared to the preoperative values in both groups (CLR-group P =0.93 versus NC-group, P =0.87). GIQLI scores were significantly improved 12 months after the operation compared with baseline values in the CLR-group ( P =0.002) and NC-group ( P =0.001). Pain symptoms and quality of life scores significantly improved 12 months postoperatively in both groups. Conclusions: NC is a feasible surgical approach for treating patients with rectal DE. Our study did not show a statistically significant difference between CLR and NC techniques in mid-term digestive and pain outcomes.
Buprenorphine Dose and Time to Discontinuation Among Patients With Opioid Use Disorder in the Era of Fentanyl
Authors: Laura C. Chambers, Benjamin D. Hallowell, Andrew R. Zullo, Taylor J. Paiva, Justin Berk, Rachel Gaither, Aidan J. Hampson, Francesca L. Beaudoin, Rachel S. Wightman
Journal: JAMA Network Open (2023)

Buprenorphine treatment for opioid use disorder (OUD) has more than doubled since 2009. However, current US Food and Drug Administration buprenorphine dosing guidelines are based on studies among people using heroin, prior to the emergence of fentanyl in the illicit drug supply. To estimate the association between buprenorphine dose and time to treatment discontinuation during a period of widespread fentanyl availability. This retrospective cohort study used statewide Rhode Island Prescription Drug Monitoring Program data. Participants were Rhode Island residents initiating buprenorphine treatment for OUD between October 1, 2016, and September 30, 2020. Data analysis was performed from December 9, 2022, to August 10, 2023. Daily dose of buprenorphine (16 mg and 24 mg) defined starting on the day of initiation based on total quantity and days' supply dispensed. Patients were censored on any dose change. Buprenorphine treatment discontinuation in the 180 days following initiation, defined as a gap in treatment of more than 27 days based on prescription fill dates and days' supply. Kaplan-Meier and Cox regression survival analyses were conducted to estimate the association between buprenorphine dose and time to treatment discontinuation, controlling for potential informative censoring and measured potential confounders. Among 6499 patients initiating buprenorphine treatment for OUD, most were aged 25 to 44 years (57%; n = 3682), were male (61%; n = 3950), and had private (47%; n = 3025) or Medicaid (33%; n = 2153) insurance. More than half of patients were prescribed a daily dose of interest at initiation (16 mg: 50%; n = 3264; 24 mg: 10%; n = 668). In Kaplan-Meier analyses, 58% of patients discontinued buprenorphine treatment within 180 days (16 mg: 59% vs 24 mg: 53%; log-rank test P = .005). In Cox regression analyses, patients prescribed a dose of 16 mg had a greater risk of treatment discontinuation than those prescribed 24 mg (adjusted hazard ratio, 1.20; 95% CI, 1.06-1.37). In this cohort study of patients initiating buprenorphine treatment from 2016 to 2020, patients prescribed a 24 mg dose of buprenorphine remained in treatment longer than those prescribed 16 mg. The value of higher buprenorphine doses than currently recommended needs to be considered for improving retention in treatment.
Comparison of Hospital Online Price and Telephone Price for Shoppable Services
Authors: Merina Thomas, James Flaherty, Jiefei Wang, Morgan Henderson, Vivian Ho, Mark Cuban, Peter Cram
Journal: JAMA Internal Medicine (2023)

US hospitals are required to publicly post their prices for specified shoppable services online. However, the extent to which a hospital's prices posted online correlate with the prices they give to a telephone caller is unknown.
The promising horizon of deep learning and artificial intelligence in flap monitoring
Authors: Linjian Liu, Ya Zhang, Xiangjun Xiao, Ruijie Xie
Journal: International Journal of Surgery (2023)

aHengyang Medical school, University of South China Hengyang 421002, China bDepartment of Gland Surgery, The Affiliated Nanhua Hospital, Hengyang Medical school, University of South China Hengyang 421002, China cDepartment of Hand&Foot Surgery, The Affiliated Nanhua Hospital, Hengyang Medical school, University of South China Hengyang 421002, China dDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany The data underlying this article will be shared by the corresponding author on reasonable request. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany, Phone number: +86 15616839074. E-mail address: [email protected] (R. Xie). *Corresponding author. Address: Department of Hand&Foot Surgery, The Affiliated Nanhua Hospital, Hengyang Medical school, University of South China Hengyang 421002, China. E-mail address: [email protected] (X. Xiao). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
Censorship of the Patient-Physician Relationship—Reply
Authors: Nadia N. Sawicki
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The clinical utility and costs of whole-genome sequencing to detect cancer susceptibility variants—a multi-site prospective cohort study
Authors: Aimee L. Davidson, Uwe Dressel, Sarah Norris, Daffodil M. Canson, Dylan M. Glubb, Cristina Fortuno, Georgina E. Hollway, Michael T. Parsons, Miranda E. Vidgen, Oliver Holmes, Lambros T. Koufariotis, Vanessa Lakis, Conrad Leonard, Scott Wood, Qinying Xu, Amy E. McCart Reed, Hilda A. Pickett, Mohammad K. Al-Shinnag, Rachel L. Austin, Jo Burke, Elisa J. Cops, Cassandra B. Nichols, Annabel Goodwin, Marion T. Harris, Megan J. Higgins, Emilia L. Ip, Catherine Kiraly-Borri, Chiyan Lau, Julia L. Mansour, Michael W. Millward, Melissa J. Monnik, Nicholas S. Pachter, Abiramy Ragunathan, Rachel D. Susman, Sharron L. Townshend, Alison H. Trainer, Simon L. Troth, Katherine M. Tucker, Mathew J. Wallis, Maie Walsh, Rachel A. Williams, Ingrid M. Winship, Felicity Newell, Emma Tudini, John V. Pearson, Nicola K. Poplawski, Helen G. Mar Fan, Paul A. James, Amanda B. Spurdle, Nicola Waddell, Robyn L. Ward
Journal: Genome Medicine (2023)

Many families and individuals do not meet criteria for a known hereditary cancer syndrome but display unusual clusters of cancers. These families may carry pathogenic variants in cancer predisposition genes and be at higher risk for developing cancer.This multi-centre prospective study recruited 195 cancer-affected participants suspected to have a hereditary cancer syndrome for whom previous clinical targeted genetic testing was either not informative or not available. To identify pathogenic disease-causing variants explaining participant presentation, germline whole-genome sequencing (WGS) and a comprehensive cancer virtual gene panel analysis were undertaken.Pathogenic variants consistent with the presenting cancer(s) were identified in 5.1% (10/195) of participants and pathogenic variants considered secondary findings with potential risk management implications were identified in another 9.7% (19/195) of participants. Health economic analysis estimated the marginal cost per case with an actionable variant was significantly lower for upfront WGS with virtual panel ($8744AUD) compared to standard testing followed by WGS ($24,894AUD). Financial analysis suggests that national adoption of diagnostic WGS testing would require a ninefold increase in government annual expenditure compared to conventional testing.These findings make a case for replacing conventional testing with WGS to deliver clinically important benefits for cancer patients and families. The uptake of such an approach will depend on the perspectives of different payers on affordability.
Chronic Medication Burden After Cardiac Surgery for Pediatric Medicaid Beneficiaries
Authors: Joyce L. Woo, Katherine A. Nash, Kacie Dragan, Sarah Crook, Matthew Neidell, Stephen Cook, Edward L. Hannan, Marshall Jacobs, Andrew B. Goldstone, Christopher J. Petit, Robert Vincent, Kathleen Walsh-Spoonhower, Ralph Mosca, T.K. Susheel Kumar, Neil Devejian, Steven A. Kamenir, George M. Alfieris, Michael F. Swartz, David Meyer, Erin A. Paul, Jane W. Newburger, John Billings, Matthew M. Davis, Brett R. Anderson
Journal: Journal of the American College of Cardiology (2023)
Impaired Renal Function and Major Cardiovascular Events in Young Adults
Authors: Junayd Hussain, Haris Imsirovic, Mark Canney, Edward G. Clark, Meghan J. Elliott, Pietro Ravani, Peter Tanuseputro, Ayub Akbari, Gregory L. Hundemer, Tim Ramsay, Navdeep Tangri, Greg A. Knoll, Manish M. Sood
Journal: Journal of the American College of Cardiology (2023)
Patient safety incidents in endoscopy: a human factors analysis of nonprocedural significant harm incidents from the National Reporting and Learning System (NRLS)
Authors: Srivathsan Ravindran, Manmeet Matharoo, Matthew David Rutter, Hutan Ashrafian, Ara Darzi, Chris Healey, Siwan Thomas-Gibson
Journal: Endoscopy (2023)

Abstract Background Despite advances in understanding and reducing the risk of endoscopic procedures, there is little consideration of the safety of the wider endoscopy service. Patient safety incidents (PSIs) still occur. We sought to identify nonprocedural PSIs (nPSIs) and their causative factors from a human factors perspective and generate ideas for safety improvement. Methods Endoscopy-specific PSI reports were extracted from the National Reporting and Learning System (NRLS). A retrospective, cross-sectional human factors analysis of data was performed. Two independent researchers coded data using a hybrid thematic analysis approach. The Human Factors Analysis and Classification System (HFACS) was used to code contributory factors. Analysis informed creation of driver diagrams and key recommendations for safety improvement in endoscopy. Results From 2017 to 2019, 1181 endoscopy-specific PSIs of significant harm were reported across England and Wales, with 539 (45.6%) being nPSIs. Five categories accounted for over 80% of all incidents, with “follow-up and surveillance” being the largest (23.4% of all nPSIs). From the free-text incident reports, 487 human factors codes were identified. Decision-based errors were the most common act prior to PSI occurrence. Other frequent preconditions to incidents were focused on environmental factors, particularly overwhelmed resources, patient factors, and ineffective team communication. Lack of staffing, standard operating procedures, effective systems, and clinical pathways were also contributory. Seven key recommendations for improving safety have been made in response to our findings. Conclusions This was the first national-level human factors analysis of endoscopy-specific PSIs. This work will inform safety improvement strategies and should empower individual services to review their approach to safety.