tbuckley/cabot-search huggingface dataset:
Crime, Its Cause and Treatment.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Magnetic Resonance Imaging
Authors: D. Sappey-Marinier, A. Briguet
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neurological Dysfunction of the Bladder in Workers Exposed to Dimethylaminopropionitrile
Authors: Kathleen Kreiss
Journal: JAMA (1980)

Neurogenic bladder dysfunction, characterized by hesitancy, need to strain, decreased stream, and increased duration of urination, developed in 104 (63%) of 166 employees working in the manufacture of polyurethane foam. Highest rates of illness (69%) occurred in production workers, and no illness occurred in office or warehouse workers. Onset of the epidemic coincided with introduction of a catalyst, dimethylaminopropionitrile (DMAPN), and monthly case incidence rates increased as DMAPN use increased. Outbreak ceased abruptly when DMAPN use was stopped. Of eight patients who underwent neurourologic testing during recovery, seven lacked either detrusor reflex or normal sensation of bladder filling; seven had a subclinical sensory abnormality; three had prolonged sacral-evoked responses; and two of these three had limb motor neuropathies. Dimethylaminopropionitrile is unique among known neurotoxins in producing urinary symptoms more frequently than limb nerve symptoms. (<i>JAMA</i>243:741-745, 1980)
The Teaching Hospital's Growing Surgical Caseload
Authors: Frank A. Sloan
Journal: JAMA (1985)

A competitive marketplace potentially creates new pressures for teaching hospitals. To assess possible trends in teaching hospitals' case-load, we studied surgical utilization in 1972 and 1981 using two national data sets. The percentage of total patients hospitalized for surgery increased in teaching hospitals between 1972 and 1981. Nonteaching hospitals adopted several new procedures, such as hip arthroplasty. However, increased volume attributable to the spread of procedures to additional hospitals was small when compared with volume increases experienced by hospitals that performed these procedures in 1972. Teaching hospitals' caseloads grew for well-established surgical procedures such as cholecystectomy, delivery, and mastectomy and for newer, high-technology procedures such as hip arthroplasty and coronary artery surgery. Overall surgical case complexity was relatively high in teaching hospitals in 1972, and the disparity with nonteaching hospitals increased during the decade. Distribution of surgical patients by payment source varied appreciably among surgical procedures, but not among hospitals by teaching status. Teaching hospitals were successful in attracting patients from 1972 to 1981; however, several new pressures are emerging that should be watched. (<i>JAMA</i>1985;254:376-382)
A Manual of Diseases of the Nervous System.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Control of Football Injuries.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Clinical Interpretation of Blood Examinations.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nesidioblastosis in Familial Endocrine Adenomatosis
Authors: James E. Vance
Journal: JAMA (1969)

Symptomatic and asymptomatic members of a family with multiple endocrine adenomatosis (MEA) (pancreatic islet, parathyroid, and adrenal cortex) were studied. Of the six subjects studied representing three generations, all had excessive secretion of insulin, three showed excessive plasma glucagon responses to oral administration of dextrose, and four had elevated plasma gastrin levels. This evidence of islet hyperactivity suggests the following: (1) A genetic defect resulted in proliferation of the primordial cell of the islands of Langerhans, a condition termed nesidioblastosis. (2) Neoplastic islet cells have the capacity to secrete insulin, glucagon, and/or gastrinlike peptides. (3) The variable involvement of other endocrine glands in the familial MEA syndrome may be secondary to chronic hypersecretion of one or more of the islet hormones.
Medical Schools in the United States, 2007-2008
Authors: Barbara Barzansky
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Colonic-Cutaneous Fistula
Authors: MARGARET M. LaMANNA, PHILIP S. YUSSEN, JANET A. PARKER
Journal: Clinical Nuclear Medicine (1985)

Radiologic diagnosis of enterocutaneous fistulae has been limited to opacification of the fistulous tract using a water soluble contrast material. The authors present a case of a post-traumatic colonic-cutaneous fistula, demonstrated by a radionuclide methylene blue enema study.
Recovery of Infectious Virus From Adenovirus Type-12 Tumor Cells&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1968)

Journal Article Recovery of Infectious Virus From Adenovirus Type-12 Tumor Cells Get access A. Marti, A. Marti Departments of Pediatrics and Microbiology, University of Miami School of Medicine and Variety Children's Research Foundation, Miami, Florida 33155 Search for other works by this author on: Oxford Academic PubMed Google Scholar J. D. Connor, J. D. Connor Departments of Pediatrics and Microbiology, University of Miami School of Medicine and Variety Children's Research Foundation, Miami, Florida 33155 Search for other works by this author on: Oxford Academic PubMed Google Scholar M. M. Sigel M. M. Sigel Departments of Pediatrics and Microbiology, University of Miami School of Medicine and Variety Children's Research Foundation, Miami, Florida 33155 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 40, Issue 2, February 1968, Pages 243–247, https://doi.org/10.1093/jnci/40.2.243 Published: 01 February 1968 Article history Received: 14 June 1967 Accepted: 27 September 1967 Published: 01 February 1968
The Era of the Patient
Authors: Ronald S. Banner
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Dr Reiser<sup>1</sup>is to be lauded for his scholarly yet lucid and compelling description of "The Era of the Patient." While some may find his suggestions for using a consumer consultant as too radical, I would like to cite yet another use for the consumer consultant. When Reiser describes influencing education through consumer instructors, he refers only to educating medical students. What about continuing education of practitioners? As a general internist, I have been frustrated with the limits of continuing medical education, which generally focuses on diseases and uses patients' pathognomonic symptoms rather than exploring features unique to a particular patient (idiosyncratic features). For example, in internal medicine education, subspecialty teaching predominates, and when the term "general internal medicine" is used in an educational setting, it frequently covers other topics, such as women in medicine, violence, health care reform, preventive medicine, physician-assisted suicide, sexually transmitted diseases,
Highlights from Recent Cancer Literature
Journal: Cancer Research (2017)

Zeb1 Promotes MetastasisCell culture and mouse models of pancreatic adenocarcinoma (PDAC) have implicated the epithelialmesenchymal transition (EMT) in tumor development and progression to metastasis.Prior work suggested EMT was dispensable for PDAC metastasis.Krebs and colleagues now demonstrate that the Zeb1-EMT transcription factor (but not Snail/Twist EMT transcription factors) was required for efficient PDAC development and metastasis.Zeb1 drove progression through transcriptional regulation of genes associated with addiction to mutant Kras and prometastatic proficiency, with Zeb1 deficiency altering cellular plasticity, stemness, and metabolic fitness.These findings suggest that much still needs to be understood before general anti-EMT therapeutic efforts may be used to prevent metastatic progression, as histologic context was a critical determinant for which EMT factor should be targeted for inhibition.(Image courtesy of Wikimedia Commons.)
Laboratory Manual of Biological Chemistry with Supplement
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights of This Issue
Journal: Clinical Cancer Research (2010)

Effective treatments for pancreatic adenocarcinoma that are less invasive and less toxic are needed. In this study, Glazer and colleagues used targeted delivery of gold nanoparticles to treat pancreatic adenocarcinoma cells in vitro and in vivo. They demonstrated that the nanoparticles released heat upon exposure to a noninvasive focused radiofrequency field. Animals treated with the targeted gold nanoparticles and the radiofrequency field suffered no toxicities and did not have evidence of nonmalignant tissue abnormalities, while the malignant cells showed evidence of thermally induced apoptosis and necrosis. This experimental approach has potential for the noninvasive treatment of cancer.IL-6 production is increased in drugresistant ovarian cancer cells and in the serum and ascites of ovarian cancer patients. Siltuximab is a chimeric murine anti-human IL-6 monoclonal antibody that has been studied previously in human cancers. Here, Guo and colleagues found that siltuximab specifically suppressed IL-6-induced Stat3 phosphorylation and Stat3 nuclear translocation in ovarian cancer cells. Treatment with siltuximab significantly decreased Stat3 downstream protein levels, including MCL-1, Bcl-XL and survivin. Siltuximab also increased the cytotoxic effects of paclitaxel in vitro. These results suggest that inhibition of IL-6 signaling may be effective for ovarian cancer treatmentEpithelial-mesenchymal transition (EMT) plays a critical role in cancer progression. Although the Foxo3a transcription factor is known to regulate the expression of cell cycle- and apoptosis-related genes, its role in EMT needs to be explored further. Here, Shiota and colleagues examined Foxo3a expression in urothelial cancer specimens. They found that Foxo3a expression levels were decreased in invasive urothelial cancer and that Foxo3a was an independent prognostic factor. Further, Foxo3a regulated the motility of urothelial cancer cells through the regulation of EMT-associated proteins (Twist1, YB-1 and E-cadherin). These results implicate Foxo3a in cancer progression and the regulation of EMT.Snail, which contributes to epithelialmesenchymal transition (EMT), has been implicated in cancer progression. Here, Kosaka and colleagues investigated the biological significance of Snail in upper urinary tract urothelial carcinoma (UTUC). They observed strong Snail staining in invasive UTUC, and found that Snail was an independent prognostic factor. Further, targeting Snail by siRNA resulted in decreased invasion activity (and an accompanying reduction in mesenchymal markers and matrix metalloproteinases) in urothelial carcinoma cells. These results suggest that Snail-induced EMT represents an attractive target for the treatment of UTUC.
Spontaneous Pneumothorax
Authors: K Paape, W A Fry
Journal: BMJ (1948)

Most cases of spontaneous pneumothorax can be handled either expectantly or by tube thoracostomy with good results. When surgical intervention is required, good results from treatment can be expected with minimal morbidity, a very low recurrence rate, and a mortality rate near zero. The traditional surgical approach has been a transaxillary thoracotomy with bleb resection and apical mechanical pleurodesis. A similar procedure, however, can be performed by VATS and may ultimately replace thoracotomy as the technique of choice.
Rejection of Lethal Ascites Tumors After Subcutaneous Inoculation: A Phenomenon of Antigenic Expression?&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: Apffel, Charles A., Peters, John H.
Journal: JNCI Journal of the National Cancer Institute (1967)

Journal Article Rejection of Lethal Ascites Tumors After Subcutaneous Inoculation: A Phenomenon of Antigenic Expression? Get access Charles A. Apffel, Charles A. Apffel Ira T. Nathanson Research Laboratories, Pondville Hospital, Walpole, Massachusetts 02081, and Harvard University, School of Public Health, Department of Microbiology, Boston, Massachusetts 02115 Search for other works by this author on: Oxford Academic PubMed Google Scholar John H. Peters John H. Peters Ira T. Nathanson Research Laboratories, Pondville Hospital, Walpole, Massachusetts 02081, and Harvard University, School of Public Health, Department of Microbiology, Boston, Massachusetts 02115 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 39, Issue 6, December 1967, Pages 1129–1139, https://doi.org/10.1093/jnci/39.6.1129 Published: 01 December 1967 Article history Received: 13 March 1967 Published: 01 December 1967
Hypereosinophilic Syndrome
Authors: M Koike, T Ishiyama
Journal: New England Journal of Medicine (2003)

Ten HES cases, which satisfied the Chuside criteria are reviewed. We found several types of HES--mild forms, often accompanied by edema, and more severe forms accompanied by vascular, lung and heart disorders. It is not necessary to treat some milder forms while the more severe forms often respond to large dose of prednisolone. Now that the diseases, which share a common hypereosinophilic factor, have been defined and HES is being seen in variants of various diseases, the concept of HES has reached a turning point. The administration of appropriate treatment to the particular individual case appears to be advisable.
The clinical evidence for postbiotics as microbial therapeutics
Authors: Alexis Mosca, Ana Teresa Abreu Y Abreu, Kok Ann Gwee, Gianluca Ianiro, Jan Tack, Thi Viet Ha Nguyen, Colin Hill
Journal: Gut Microbes (2022)

An optimally operating microbiome supports protective, metabolic, and immune functions, but disruptions produce metabolites and toxins which can be involved in many conditions. Probiotics have the potential to manage these. However, their use in vulnerable people is linked to possible safety concerns and maintaining their viability is difficult. Interest in postbiotics is therefore increasing. Postbiotics contain inactivated microbial cells or cell components, thus are more stable and exert similar health benefits to probiotics. To review the evidence for the clinical benefits of postbiotics in highly prevalent conditions and consider future potential areas of benefit. There is growing evidence revealing the diverse clinical benefits of postbiotics in many prevalent conditions. Postbiotics could offer a novel therapeutic approach and may be a safer alternative to probiotics. Establishing interaction mechanisms between postbiotics and commensal microorganisms will improve the understanding of potential clinical benefits and may lead to targeted postbiotic therapy.