tbuckley/cabot-search huggingface dataset:
Recombinant allergens
Authors: R. Valenta, S. Vrtala, S. Laffer, S. Spitzauer, D. Kraft
Journal: Allergy (1998)

A great variety of recombinant plant, mite, mold, mammal, and insect allergens have been expressed in heterologous hosts (e.g., Escherichia coli), their cDNA being used as a template. The number of biologically active recombinant allergens available for experimental, diagnostic, and therapeutic purposes is increasing tremendously. Recombinant allergens have proven to be valuable tools to investigate T‐cell and B‐cell recognition of allergens as well as to study mechanisms of specific IgE regulation. The immunologic equivalence of many relevant recombinant allergens with their natural counterparts has been demonstrated, and the three‐dimensional structures of several recombinant allergens have been described recently. As a result of extensive cross‐reactivities among the relevant allergens, it appears that the number of epitopes needed for diagnosis and specific immunotherapy is less diverse than originally anticipated and might be soon covered by recombinant molecules. Recombinant allergens have been used for successful in vitro, as well as in vivo, allergy diagnosis, and work is in progress to produce recombinant allergen derivatives with reduced anaphylactic potential to improve current forms of immunotherapy.
Letter: Leukopenia after postmastectomy irradiation
Authors: D. L. Wishart
Journal: JAMA (1976)

<h3>To the Editor.—</h3> It occurs to me it would have been instructive to match the patients in Drs Lewis and Paterson's study with a similar population not receiving postmastectomy radiotherapy. Are we certain that the surgical procedures and whatever other attendant routines are carried out at Rochester General Hospital do not produce a leukopenia? Drs Paterson and Lewis indicate that they plan to continue this study; it seems reasonable that a matched control population should be included.
Transport of Particles of Colloidal Gold within and from Rat Lung after Local Deposition by Alveolar Microinjection
Authors: Graham Patrick, Christine Stirling
Journal: Environmental Health Perspectives (1992)

Because inhalation and intratracheal instillation deposit particles throughout the respiratory tract, these methods of administration give little information on the movement of particles within the lung and no direct information on the clearance kinetics from locally defined sites within alveolar tissue.Approximately 0.05 tsL of "'Au-labeled gold colloid was administered to 32 rats by microinjection into a small volume of subpleural alveoli.Its fate was studied by whole-body counting and serial sacrifice over 15 months.The kinetics of dearance from the subpleural deposition site showed that there was no rapid removal of particles, and the main clearance process was defined by an exponential term with a half- timeaverang583 days.There was a wide variation between individual aninals.The distribution of "%Au at sacriffceshwed that the gold coiloid was nearly all retained within the respiratory tract.The particles were not appreciably redistributed throughout the lung volume, so mostof the material not deared from the lung remained close to the deposition site.At the later times after microinjection, much of the gold coloid was associated with thickened pleura and adjoining septae.
Anticoagulant Therapy
Authors: Robert D. Eastham
Journal: JAMA (1980)

<h3>To the Editor.—</h3> In the report of Szklo et al (242:1261, 1979) and the editorial (242:1291, 1979), the indications for a carefully controlled large multi-institutional, double-blind, randomized study of the long-term effects of anticoagulant therapy during the acute phase of myocardial infarction are discussed. One additional variable not mentioned is the level of anticoagulation. The therapeutic range of the prothrombin ratio used in the United Kingdom (British Comparative Ratio) is 2.0 to 4.0. For many years I have used the activated partial thromboplastin time (APTT) to control long-term warfarin therapy.<sup>1</sup>Using a Coag-a-pet coagulometer, I have recently collected 1,109 paired prothrombin ratios and APTTs during long-term warfarin therapy. The normal untreated APTT mean value is 32±10 s (2 SD). Of 685 results from anticoagulated patients with a prothrombin ratio of 2.0 to 2.9, 33% (226) had APTT results of less than 42 s, while out of 424 results with a prothrombin
Late infection after total hip replacement.
Journal: BMJ (1977)

family doctors and in a few instances by psychiatrists.The most common cause of death was poisoning, which accounted for 57 of those diagnosed as mentally ill.In about half the cases, whether classified as mentally ill or not, the blood alcohol concentration was raised.Overall the findings seem strongly to favour that a sub- stantial number of cases of accidental death are concealed suicides.The investigators were, however, rightly cautious in not pushing their conclusions too far.What they did conclude, and this seems to be indisputable, is that, like undetermined deaths, accidental deaths-especially those due to selfpoisoning, solitary drowning, and falls from a height-should be included in the mortality of mental illness.
CONSECRATIO MEDICI
Authors: HARVEY CUSHING
Journal: JAMA (1926)

There is an old saying that interest does not bind men together: interest separates men; there is only one thing that can effectively bind people, and that is a common devotion. This, a common devotion, more than any other possible influence, serves to overcome the self-depravities and conceits inherent in us which, uncontrolled, represent the chief defect in our natures. Our loyalties, to be sure—loyalty to nation, to a cause, to community, to school, to family, to friend—are somewhat akin, yet there may be something of personal interest, prejudice or defense in these particular reactions which makes them not wholly unselfish. So let us believe, for our present purposes at least, that "devotion" not only implies a higher standard of self-effacement but still carries something of its quondam religious significance. And it is of the doctor's consecration to his task that I wish to speak, the kind of unselfish relation
It Sounds Glamorous, but TV Celebrity Status Offers Physician Little Respite
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nonepidemic incidence of idiopathic facial paralysis. Seasonal distribution of 419 cases in three years
Authors: K. K. Adour
Journal: JAMA (1974)

We have analyzed 419 cases of Bell palsy within three years, with no evidence for an age differential in seasonal occurrence or for epidemicity. Cold weather could not be entirely ruled out in a geographic region of mild climate without wide seasonal variation. Bell palsy is probably not contagious, is randomly distributed among persons of all ages, and is not related to seasonal change.
Rubella Immunization
Authors: Kenneth L. Herrmann
Journal: JAMA (1976)

A long-term comparative field trial of three live, attenuated rubella vaccines (HPV-77 DE-5, HPV-77 DK-12, and Cendehill) was initiated in 1969 on the islands of Kauai and Hawaii in the state of Hawaii. Rubella hemagglutination-inhibition (HI) tests on prevaccination serum specimens from 7,931 children in the two study areas indicated an overall susceptibility to rubella of nearly 70%. The rates of seroconversion of 5,153 seronegative subjects to HPV-77 DE-5, HPV-77 DK-12, and Cendehill vaccine were 97.5%, 99.9%, and 99.8%, respectively. Over the subsequent four-year follow-up period, during which time natural exposure to rubella was minimal, the percent decline of geometric mean titers did not vary substantially among the three vaccine groups and measured about twofold for all three. A total of only 28 vaccinees (0.7%) who seroconverted to one of the vaccines in 1969 lost all measurable antibody by 1974. Measurable antibody persisted in more than 98% of all vaccinees over the four-year period. Reinfection, thought possibly to be an important factor in maintaining titers, did not occur frequently in the study population and could not be related to outbreaks of disease. (<i>JAMA</i>235:2201-2204, 1976)
Impaired elastic properties of the aortic root in patients with bicuspid aortic valve Stefano Nistri, Maria D. Sorbo, Cristina Basso, Gaetano Thiene. Medical Service, Arma dei Carabinieri., Padova, Italy, Dpmt. of Pathology - University of Padua, Padova, Italy
Journal: Journal of the American College of Cardiology (2001)
AIDS dementia may be linked to metabolite of tryptophan
Authors: P. Cotton
Journal: JAMA (1990)

QUINOLINIC ACID is intriguing researchers as a possible cause and marker of neurological damage in human immunodeficiency virus (HIV) disease. It is a neurotoxic convulsant metabolite of tryptophan that is activated by interferon gamma. It is elevated with any infection, from a common rhinovirus to the mysterious lentivirus linked to acquired immunodeficiency syndrome (AIDS). But quinolinic acid remains elevated for extended periods with HIV and increases as much as a 1000-fold over controls in patients with AIDS dementia complex, says Melvyn Heyes, PhD, a visiting scientist in the analytical biochemistry section at the National Institute for Mental Health in suburban Washington, DC (Maryland). It binds to and may down-regulate Nmethyl-D-aspartate receptors, which are involved in normal neurotransmission, neural regeneration, memory, and synaptic plasticity. It can also induce seizures and nerve cell death, says Heyes. "There is a wide spectrum of possible consequences known to occur in AIDS and other infectious
A fatal poisoning from the Oregon rough-skinned newt (Taricha granulosa)
Authors: S. G. Bradley
Journal: JAMA (1981)

CERTAIN newts possess a neurotoxin that can be fatal if ingested. Toxic varities include the<i>Taricha</i>species that are found in Oregon, California, and southern Alaska (Figure). In addition, certain species found on the east coast such as the<i>Notophthalmus</i>species of the Carolinas are toxic, but the toxin is only 1/100th as potent as that found in Taricha.<sup>1</sup> <h3>Report of Cases</h3><h3>Case 1.—</h3> A 29-year-old man drank approximately 150 mL of whiskey at about 11 AM July 9, 1979. At 6 PM he swallowed a 20-cm newt on a dare. Within ten minutes he complained of tingling of the lips. During the next two hours he began complaining of numbness and weakness and stated that he thought he was going to die. He refused to be transported to a hospital and was left alone for 15 minutes and then experienced cardiopulmonary arrest. Resuscitation measures were initiated, but two
Sodium Fluoride and Cell Growth
Authors: C. G. Learoyd
Journal: BMJ (1963)

injected to pregnant rats.No cardiovascular abnormalities were produced, but anoph- thalmia occurred in some of the test foetuses.In addition abnormalities of the central nervous system were produced.The net incidence of malformations in this series was similar to that occurring in my own.In view of the work of Robson and his co-workers,' who have demonstrated abnor- malities in the rodent placenta following the administration of 5H.T., it is tempting to suggest the possibility that microphthalmia and other abnormalities in the derivatives of the neural ectoderm in these animals could be related to anoxia.This possibility is supported by the findings of Brent and Franklin,4 who clamped the uterine vessels for up to three hours on the ninth day of gestation of the rat.On the twenty-first day the abnormalities observed were microphthalmia, renal aplasia and agenesis, anen- cephaly, and hydrocephalus.
Errors in Figure
Journal: JAMA Network Open (2020)

Qu Tian, PhD, MS; Susan M. Resnick, PhD; Michelle M. Mielke, PhD; Kristine Yaffe, MD; Lenore J. Launer, PhD; Palmi V. Jonsson, MD; Giulia Grande, MD; Anna-Karin Welmer, PhD; Erika J. Laukka, PhD; Stefania Bandinelli, MD; Antonio Cherubini, MD, PhD; Caterina Rosano, MD; Stephen B. Kritchevsky, PhD; Eleanor M. Simonsick, PhD; Stephanie A. Studenski, MD; Luigi Ferrucci, MD, PhD
Abstract 11277: Comparison Among Drug-Eluting Balloon, Drug-Eluting Stent, and Plain Balloon Angioplasty for Treatment of In-Stent Restenosis: A Network Meta-Analysis of 11 Randomized Controlled Trials
Authors: Jonghanne Park, Joo Myung Lee, Jeehoon Kang, Ki-Hyun Jeon, Ji-hyun Jung, Sang Eun Lee, Jung-Kyu Han, Hack-Lyoung Kim, Han-Mo Yang, Kyung Woo Park, Hyun-Jae Kang, Bon-Kwon Koo, Hyo-Soo Kim
Journal: Circulation (2014)

Objective: The optimal treatment option for in-stent restenosis (ISR) is not established. We performed a Bayesian network meta-analysis comparing the efficacy and safety of drug-eluting balloon (DEB), drug-eluting stent (DES) or plain old balloon angioplasty (POBA) for treatment of ISR. Design: Systemic review and Bayesian network meta-analysis using random-effects model. The primary outcome was target lesion revascularization (TLR). The secondary outcomes were myocardial infarction (MI), all-cause mortality or major adverse cardiovascular events (MACE). The pairwise posterior median odds ratio (OR) with 95% credible interval (CrI) was the effect measure. Data Sources: PubMed, EMBASE, BioMed Central, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, conference proceedings through February 2014. Eligibility Criteria for Selecting Studies: Randomized controlled trials (RCTs) comparing DEB, DES, or POBA for treatment of ISR. Results: This analysis included 2,059 patients from 11 RCTs. The risk of TLR was markedly lower in patients treated with DEB (OR 0.22, 95% CrI 0.10-0.42) or DES (OR 0.24, 95% CrI 0.11-0.47) than in those treated with POBA. The risk of TLR (OR 0.92, 95% CrI 0.43-1.90) was similar between DEB and DES. The risk of MI or all-cause mortality was lowest in the DEB group compared with DES or POBA, which did not meet statistical significance. The risk of MACE was significantly lower in DEB (OR 0.24, 95% CrI 0.12-0.39) or DES (OR 0.28, 95% CrI 0.14-0.53) than in POBA, but it was similar between DEB and DES group (OR 0.84, 95% CrI 0.45-1.50). The probability to be ranked as the best treatment were 59.9% (DEB), 40.1% (DES), and 0.1% (POBA) in terms of TLR, whereas, 63.0% (DEB), 35.3% (POBA), and 1.7% (DES) in terms of MI. Conclusions: DEB or DES was markedly better than POBA in preventing TLR, but not for MI or mortality in treatment of ISR. DEB resulted in less MI than DES without statistical significance.
Department of Public Health.
Authors: Warren E. Anderson
Journal: JAMA (1897)

Pensacola, Ala., Nov. 24, 1897. Hon. Frank S. Gardner, Secretary New York Board of Trade and Transportation, New York City. <h3>Dear Sir:</h3> —In response to your inquiry concerning the efficiency of the Marine-Hospital Service in the conduct of Federal health affairs, I forwarded you some days ago copies of theJournal of the American Medical Association, the<i>Florida Times Union</i>and<i>Citizen</i>and<i>New Orleans Times Democrat</i>, as I was not able to reply immediately on account of certain professional engagements. I desire now to answer your queries briefly, but by the presentation of such facts only as may not be successfully controverted, and which are detailed without malice toward any one, or animus of a personal character whatever. The first objection to be urged against such control of our health affairs by this service or branch of the Federal Government, is one relating to its organic construction. You are
Hepatology Highlights
Authors: Joseph F. Pisa, Robert S. Brown, Petra Hirsova, Robert E. Schwartz, Tejasav S. Sehrawat, Nicholas W. Russo, Enis Kostallari, Zaid H. Tafesh, Brett Fortune, Hirsh D. Trivedi, Daryl T.Y. Lau, Angel Morales‐Santiago, Joel Wedd, Samuel C. Buchl, Jessica L. Maiers
Journal: Hepatology (2020)

Pisa, Joseph F.; Brown, Robert S. Jr.1; Hirsova, Petra2; Schwartz, Robert E.1; Sehrawat, Tejasav S.2; Russo, Nicholas W.; Kostallari, Enis2; Tafesh, Zaid H.†; Fortune, Brett1; Trivedi, Hirsh D.‡; Lau, Daryl T.Y.3; Morales‐Santiago, Angel§; Wedd, Joel4; Buchl, Samuel C.2; Maiers, Jessica L.2 Author Information
VITAMIN A AND DISEASE
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Laparoscopic cholecystectomy. A remarkable development
Authors: B. M. Wolfe
Journal: JAMA (1991)

Several remarkable developments have occurred over the last 2 years in the management of symptomatic gallstones. A fundamentally different technique for the conduct of cholecystectomy was developed, described, and popularized by surgeons in both France and the United States.<sup>1,2</sup>The technique is described briefly by Miller-Catchpole<sup>3</sup>in this issue ofThe Journaland involves the use of a laparoscope and instrument insertion through trocars, thereby avoiding the traditional incision. Advantages attributed to laparoscopic cholecystectomy compared with the traditional or open cholecystectomy include diminished postoperative pain, shorter hospitalization and associated cost, more rapid recovery and return to full activity, and a superior cosmetic result. Initial reports on the laparoscopic procedure were followed by an unprecedented (at least for biliary tract surgeons) rush by surgeons to learn the new technique, advertisements and/or promotions by both the manufacturers of the required equipment and health care providers, and consumer demand for the
Measuring quality of life near the end of life
Authors: N. R. Zweibel
Journal: JAMA (1988)

Danis and colleagues<sup>1</sup>have chosen to examine an important question in medical ethics—to what extent should quality-of-life judgments be applied in decision making for incompetent patients when no advance directives exist? Few studies in this field have attempted to empirically assess the validity of decision making for incompetent patients. Fewer still have examined "informed treatment preferences" by asking patients who have already experienced a particular intervention to project what they think their future treatment preferences for this intervention might be. For these reasons, the study by Danis et al is a noteworthy contribution to the literature. One question that can be raised about this research, however, concerns the way in which its authors measured quality of life and the implications of this measurement strategy for interpretation of the findings related to this variable. The authors obtained data on willingness to repeat intensive care and on perceived quality of life (among
Role of Polyclonal Cell Activation in the Initiation of Immune Complex-Mediated Pulmonary Injury Following Antigen Inhalation
Authors: Bruce J. Shenker, Thomas N. Mann, William F. Willoughby
Journal: Environmental Health Perspectives (1980)

The lung, by virtue of its anatomic situation, provides environmental antigens with unique access to host lymphoid tissues. In order to better understand the biologic consequences of antigen inhalation, we developed in animal model in which soluble proteins are administered in aerosol form to rabbits. By labeling these proteins with fluorochrome dyes or radioactive isotopes, the uptake, distribution, and fate of such proteins can be demonstrated both morphologically and quantitatively. Prompt host-antibody responses can be demonstrated to inhaled antigen, but not to comparable amounts of ingested antigen. Repeated administrations of antigen aerosol to immune animals produced little injury; in contrast, administration of aerosols containing phytohemagglutinin or cancanavalin A (Con A), plant lectins which activate leucocytes in a polyclonal fashion, induced a diffuse interstitial pneumonitis. When immune animals inhaled antigen plus Con A, devastating pulmonary necrosis was induced, in association with localized deposits of immune complexes containing antigen, antibody and complement. Such necrotic injury healed by scarring within 4 weeks. The necrotizing injury could be prevented by either decomplementation with cobra venom factor, or through inhibition of leucocyte responsiveness to Con A by administration of cholera toxin, a cAMP agonist. These studies indicate that antigen inhalation may serve as an important means of establishing
Chorea in childhood systemic lupus erythematosus
Authors: M. I. Weintraub
Journal: JAMA (1977)

<h3>To the Editor.—</h3> Awareness that neurological manifestations other than seizures and psychosis can occur as the initial aspect of childhood systemic lupus erythematosus (SLE) has not been sufficiently emphasized,<sup>1</sup>although they were not observed in the excellent study of Coleman and co-workers (<b>237</b>:1095-1100, 1977). The following case of acute chorea is instructive because it adds further to the clinical spectrum of childhood SLE. <h3>Report of a Case.—</h3> Sudden choreiform movements of the hands, mouth, tongue, and feet developed in a previously healthy 13-year-old girl. These progressed over a three-week period and were associated with slurred speech and a tendency to fall. The patient had a low grade fever, and laboratory tests confirmed the diagnosis of SLE with strongly positive antinuclear antibody, reduced complement, anemia, elevated sedimentation rate, leukopenia, and proteinuria. She was treated with haloperidol (Haldol) and corticosteroids, which resulted in clinical recovery from chorea. A computerized axial