tbuckley/cabot-search huggingface dataset:
Marked underestimation of liver fat content as measured by magnetic resonance versus histology—a systematic review and meta-analysis
Authors: Sami Qadri, Kimmo Porthan, Anne Juuti, Anne Penttilä, Juhani Dabek, Tiina E. Lehtimäki, Wenla Seppänen, Johanna Arola, Perttu Arkkila, Hannele Yki-Järvinen
Journal: Journal of Hepatology (2022)
Proportion of time and degree to which liver biochemistries are out-of-range predicts time to first occurrence of negative hepatic outcomes in people with primary biliary cholangitis
Authors: Timothy Ritter, Christina Hanson, Christopher C. Fernandes, Joanna MacEwan, Xin Zhao, Craig Parzynski, Erik Ness, Gail Cawkwell, Darren Wheeler, Tracy Mayne
Journal: Journal of Hepatology (2022)
The genomic landscape of IDH1 mutant intrahepatic cholangiocarcinoma: a multicentre comprehensive analysis
Authors: Margherita Rimini, Teresa Mercade Macarulla, Valentina Burgio, Sara Lonardi, Monica Niger, Mario Scartozzi, Ilario Raposelli, Giuseppe Aprile, Francesca Ratti, Federica Pedica, Helena Verdaguer, Floriana Nappo, Federico Nichetti, Eleonora Lai, Martina Valgiusti, Alessandro Cappetta, Carles Fabregat, Matteo Fassan, Filippo De Braud, Marco Puzzoni, Giovanni Luca Frassineti, Francesca Simionato, Francesco De Cobelli, Luca Aldrighetti, Lorenzo Fornaro, Stefano Cascinu, Andrea Casadei Gardini
Journal: Journal of Hepatology (2022)
A model to predict drinking population at-risk of liver disease in France: a tool for decision-making public health policies
Authors: Claire Delacôte, Line Carolle Ntandja Wandji, Alexandre Louvet, Pierre Bauvin, Guillaume Lassailly, Massih Ningarhari, Sebastien Dharancy, Philippe Mathurin, Sylvie Deuffic-Burban
Journal: Journal of Hepatology (2022)
Gluco-regulatory disturbances in primary biliary cholangitis and non-alcoholic fatty liver disease compared with healthy individuals
Authors: Anne-Sofie Houlberg Jensen, Henriette Ytting, Josephine Grandt, Andreas Møller, Mikkel Werge, Elias Rashu, Liv Hetland, Mira Thing, Anders Junker, Lise Hobolth, Christian Mortensen, Flemming Bendtsen, Flemming Tofteng, Mogens Vyberg, Reza Serizawa, Lise Lotte Gluud, Nicolai J Wewer Albrechtsen
Journal: Journal of Hepatology (2022)
Novel endosomal trafficking adaptor for the regulation of NAFLD to NASH progression
Authors: Karsten Motzler, Karsten Nalbach, Revathi Sekar, Ana Alfaro, Martin Hrabe de Angelis, Matthias Blüher, Michael Roden, Stephan Herzig, Natalie Krahmer, Christian Behrends, Anja Zeigerer
Journal: Journal of Hepatology (2022)
Multi-target engagement effect of a novel long-acting Glucagon/ GIP/GLP-1 triple agonist, HM15211, in animal model of NASH/ fibrosis
Authors: Jong Suk Lee, Jung Kuk Kim, Seonmyeong Lee, Yohan Kim, Jaehyuk Choi, Hyunjoo Kwon, Eun Jin Park, Sung Min Bae, Sang Hyun Lee, In Young Choi
Journal: Journal of Hepatology (2022)
High tolerance of hepatitis E virus towards alcohol-based disinfectants
Authors: Patrick Behrendt, Martina Friesland, Jan-Erik Wissmann, Volker Kinast, Yannick Stahl, Dimas Praditya, Lucas Hueffner, Pia Maria Nörenberg, Birgit Bremer, Benjamin Maasoumy, Jochen Steinmann, Britta Becker, Dajana Paulmann, Florian H.H Brill, Joerg Steinmann, Rainer Ulrich, Yannick Brueggemann, Heiner Wedemeyer, Daniel Todt, Eike Steinmann
Journal: Journal of Hepatology (2022)
Development and validation of the gender-equity model for liver allocation (GEMA) to prioritize liver transplant candidates
Authors: Manuel Rodríguez-Perálvarez, Antonio M. Gómez-Orellana, Avik Majumdar, Geoff McCaughan, Paul Gow, David Guijo-Rubio, César Hervás, Michael Bailey, Emmanuel Tsochatzis
Journal: Journal of Hepatology (2022)
Clinical utility of non-ceruloplasmin copper determined by copper speciation for monitoring Wilson disease therapy: comparative data analysis with 24-hour urinary copper excretion from the CHELATE trial
Authors: Michael Schilsky, Aurelia Poujois, Massimo Giovanni Zuin, Peter Ott, Karl Heinz Weiss, David Cassiman, Aftab Ala, Anna Czlonkowska, Nicolas Dubois, Naseem Amin, C.Oma Kamlin
Journal: Journal of Hepatology (2022)
High prevalence of multi-organ steatosis and fibroinflammation, identified by multi-parametric magnetic resonance imaging, in people with type 2 diabetes
Authors: Nicole Eichert, Karyna Gibbons, Azlinda Hamid, Vashist Deelchand, Jinny Woolgar, Rob Suriano, Helena Thomaides-Brears, Rajarshi Banerjee, Graham Kemp, Sarah Ali, Gaya Thanabalasingham, Daniel Cuthbertson
Journal: Journal of Hepatology (2022)
CD4 T cell immunity to HEV-infection is characterized by sustained capsid-specific responses that correlate with neutralizing antibodies
Authors: Benedikt Csernalabics, Stefan Marinescu, Lars Maurer, Katharina Wild, Katharina Zoldan, Marcus Panning, Philipp Reuken, Tony Bruns, Christoph Neumann-Haefelin, Bertram Bengsch, Maike Hofmann, Robert Thimme, Viet Loan Dao Thi, Tobias Böttler
Journal: Journal of Hepatology (2022)
Favorable lipid and pruritus profile of liver-distributed farnesoid X receptor agonist TERN-101 at clinically efficacious doses in non-alcoholic steatohepatitis phase 2a LIFT study
Authors: Kris Kowdley, Eric Lawitz, Rohit Loomba, Erin Quirk, Daria Crittenden, Diana Chung, Tonya Marmon
Journal: Journal of Hepatology (2022)
Low subcutaneous adipose tissue is associated with mortality independently from portal hypertension in patients with cirrhosis
Authors: Xun Zhao, Balqis Alabdulkarim, Dana Kablawi, Marc Deschenes, Philip Wong, Tianyan Chen, Benjamin Rehany, Mohamed Abu-Nada, David Valenti, Ali Bessissow, Giada Sebastiani, Amine Benmassaoud
Journal: Journal of Hepatology (2022)
Second harmonic generation microscopy can quantify and subclassify early stages of NASH fibrosis progression: data from a screen-failure cohort of a NASH phase 2 study
Authors: Dominique Brees, Dean Tai, Clifford Brass, Nikolai Naoumov, Elaine Chng, Yayun Ren, Andreas Sailer, Douglas Applegate, Jossy George Kochuparampil, Juergen Loeffler, Li Chen, Miljen Martic, Zachary Goodman, Marcos Pedrosa, Quentin Anstee
Journal: Journal of Hepatology (2022)
Ectopic fat deposition in the liver and pancreas and the presence of excess visceral adipose tissue significantly increase hospitalisation risk following COVID-19
Authors: Tom Waddell, Adriana Roca-Fernandez, John McGonigle, Arun Jandor, Valentina Carapella, Helena Thomaides-Brears, Andrea Dennis, John Michael Brady, Rajarshi Banerjee
Journal: Journal of Hepatology (2022)
ADAPT, a score incorporating PRO-C3, for the early detection of liver fibrosis in a large population-based study
Authors: Ann T. Ma, Guillem Pera, Martina Perez, Mette Juul Nielsen, Morten Karsdal, Diana Leeming, Carmen Expósito, Alba Martínez-Escudé, Isabel Graupera, Maja Thiele, Aleksander Krag, Núria Fabrellas, Llorenç Caballeria, Pere Ginès
Journal: Journal of Hepatology (2022)
Predicting prognosis in large cohort of decompensated cirrhosis of liver (DCLD)- a machine learning (ML) approach
Authors: Ashok Choudhury, Vinod Arora, Kajali Mishra, Harshvardhan Tevethia, Vishal Kaushik, Babita Prasad, Manoj Kumar, Shiv Kumar Sarin
Journal: Journal of Hepatology (2022)
PMEPA1: an oncogene in hepatocellular carcinoma linked to TGF-beta signaling
Authors: Carmen Andreu-Oller, Marta Piqué-Gili, Marina Barcena-Varela, Roser Pinyol, Roger Esteban-Fabró, Judit Peix, Katherine E. Lindblad, Miguel Torres-Martín, Daniela Sia, Amaia Lujambio, Josep M. Llovet
Journal: Journal of Hepatology (2022)
EphB2 is a novel signaling receptor in non-alcoholic steatohepatitis liver fibrosis
Authors: Patrice Mimche, Severin Donald Kamdem, Erika Egal, Quinian Johanson, Tuan Pham, Kimberley Evason, Sihem Boudina, Michael Ortiz, Francis Sprouse, Chinthaka Mahesh Udamulle Gedara, Karina Cortez, Mahmoud Ahmed, Hesham Sadek, Mark Henkemeyer
Journal: Journal of Hepatology (2022)
Distribution of patients by guideline-defined disease phase and/ or grey zones in B-Clear, an international multicentre clinical trial
Authors: Seng Gee Lim, Cristina Pojoga, Harry Janssen, Michio Imamura, Ewa Janczewska, Robert Plesniak, Keiji Tsuji, Corneliu Petru Popescu, Diana Petrova, Adrian Gadano, Alexander Wong, Tarik Asselah, Hyung Joon Yim, Jeong Heo, Man-Fung Yuen, Gheorghe Diaconescu, Giuliano Rizzardini, Jennifer Cremer, Robert Elston, Stuart Kendrick, Geoff Quinn, Fiona Campbell, Melanie Paff, Dickens Theodore
Journal: Journal of Hepatology (2022)
Targeting the liver circadian clock by REV-ERB-alpha activation improves liver fibrosis by circadian gating of TGF-beta signaling
Authors: Mayssa Dachraoui, Frank Jühling, Natascha Roehlen, Emilie Crouchet, Romain Martin, Nicolas Brignon, Laurent Mailly, Antonio Saviano, Sarah Durand, Catherine Schuster, Emanuele Felli, Patrick Pessaux, Joachim Lupberger, Atish Mukherji, Thomas Baumert
Journal: Journal of Hepatology (2022)
Training, validation and testing of a multiscale three-dimensional deep learning algorithm in accurately diagnosing hepatocellular carcinoma on computed tomography
Authors: Wai-Kay Seto, Keith Wan Hang Chiu, Wenming Cao, Gilbert Lui, Jian Zhou, Ho Ming Cheng, Juan Wu, Xinping Shen, Lung Yi Loey Mak, Jinhua Huang, Wai Keung Li, Man-Fung Yuen, Philip Yu
Journal: Journal of Hepatology (2022)
Over-responsiveness of the IL-6/STAT3 pathway in inflammatory CD4+ T cells of patients with primary sclerosing cholangitis
Authors: Leona Dold, Leonie Frank, Philipp Lutz, Tobias Weismüller, Dominik Kaczmarek, Vittorio Branchi, Marieta Toma, Christian Strassburg, Ulrich Spengler, Bettina Langhans
Journal: Journal of Hepatology (2022)
Genetic ablation of miR-22 fosters hepatic carcinogenesis in mice
Authors: Monika Gjorgjieva, Cyril Sobolewski, Anne-Sophie Ay, Daniel Abegg, Marta Sousa, Flavien Berthou, Margot Fournier, Christine Maeder, Xavier Montet, Alexander Adibekian, Michelangelo Foti
Journal: Journal of Hepatology (2022)
Il-1beta Signal Inhibition in acute alcoholic hepatitis: a multicentre, randomised, double-blind, placebo-controlled phase 2 trial of canakinumab therapy (ISAIAH)
Authors: Nikhil Vergis, Vishal C. Patel, Karolina Bogdanowicz, Justyna Czyzewska-Khan, Rosemary Keshinro, Francesca Fiorentino, Emily Day, Paul Middleton, Stephen Atkinson, Mary Cross, Daphne Babalis, Neil Foster, Alberto Quaglia, Josephine Lloyd, Robert D. Goldin, William Rosenberg, Richard Parker, Paul Richardson, Steven Masson, Gavin Whitehouse, Cyril Sieberhagen, David Patch, Ashwin Dhanda, Emma Lord, Ewan Forrest, Nikolai Naoumov, Mark Thursz
Journal: Journal of Hepatology (2022)
Requests for drug-drug interaction data on direct-acting antivirals and enzyme inducing anti-epileptic agents: an overview of the HEP Interaction checker database of the University of Liverpool
Authors: David Burger, David Back, Jasmine Martin, Daryl Hodge, Minou Van Seyen, Justin Chiong, Alison Boyle, Fiona Marra
Journal: Journal of Hepatology (2022)
3D human NASH model as a screening-based discovery approach for selecting and prioritizing drug candidates
Authors: Radina Kostadinova, Simon Ströbel, Jana Rupp, Katia Fiaschetti, Agnieszka Pajak, Katarzyna Sanchez, Mathieu Petitjean, Li Chen, Manuela Bieri, Armin Wolf, Sue Grepper, Francisco Verdeguer
Journal: Journal of Hepatology (2022)
Non-invasive fibrosis scores as prognostic biomarkers of liver events, cardiovascular events and all-cause mortality in people with obesity and/or type 2 diabetes in the UK: a longitudinal cohort study
Authors: Quentin Anstee, Tina Landsvig Berentzen, Louise Nitze, Maximilian Jara, Mette Kjaer, Kamal Kant Mangla, Jens M. Tarp, Kamlesh Khunti
Journal: Journal of Hepatology (2022)
Survival benefit-based priority of liver transplantation in HBV-related acute-on-chronic liver failure
Authors: Peng Li, Xi Liang, Jinjin Luo, Jiaqi Li, Jiaojiao Xin, Jing Jiang, Dongyan Shi, Yingyan Lu, Hozeifa Mohamed Hassan, Qian Zhou, Shaorui Hao, Huafeng Zhang, Tianzhou Wu, Tan Li, Heng Yao, Keke Ren, Beibei Guo, Xingping Zhou, Jiaxian Chen, Lulu He, Hui Yang, Wen Hu, Shiwen Ma, Bingqi Li, Shaoli You, Shaojie Xin, Yu Chen, Jun Li
Journal: Journal of Hepatology (2022)
Reduced neutralization efficacy against SARS-CoV-2 Omicron variant after third boost of mRNA BNT162 vaccine among liver transplant recipients
Authors: Yana Davidov, Victoria Indenbaum, Michal Mandelboim, Keren Asraf, Tal Gonen, Keren Tsaraf, Oranit Cohen-Ezra, Mariya Likhter, Gil Ben Yaacov, Ital Nemet, Limor Kliker, Orna Mor, Ram Doolman, Carmit Cohen, Arnon Afek, Yitshak Kreiss, Gili Regev, Yaniv Lustig, Ziv Ben Ari
Journal: Journal of Hepatology (2022)
CD8+ T cell acquisition of the LPS receptor within the hepatic stroma shapes anti-viral/anti-tumour potential
Authors: Laura J. Pallett, Mariana Diniz, Leo Swadling, Jessica Skelton, Alexander Maini, Jessica Davies, Stephanie Kucykowicz, Nathalie Schmidt, Oliver E. Amin, Upkar Gill, Alice Burton, Jenifer Sanchez, Giuseppe Fusai, Sabela Lens, Sofía Pérez-del-Pulgar, Patrick Kennedy, Brian R. Davidson, Muzlifah Haniffa, Derek Gilroy, Marcus Dorner, Anna Schurich, Mala Maini
Journal: Journal of Hepatology (2022)
Peformance of fibrometer-derived biomarker panels for assessment of fibrosis stage in NAFLD: NIMBLE stage 1 and the NASH CRN collaborative Study
Authors: Rohit Loomba, Sudha Shankar, Katherine Yates, Clayton Dehn, James Bolognese, Brent Tetri, Kris Kowdley, Raj Vuppalanchi, Cynthia Guy, James Tonascia, Anthony Samir, Claude Sirlin, Sarah Sherlock, Kathryn Fowler, Helen Heymann, Tania Kamphaus, Roberto Calle, Arun Sanyal
Journal: Journal of Hepatology (2022)
Serum soluble program cell death-1 is predictive of hepatocellular carcinoma in untreated chronic hepatitis B patients
Authors: Rachel Wen-Juei Jeng, Yu-Ju Chu, Mei-Hung Pan, Hui-Han Hu, Wun-Sheng Luo, Chien-Yu Su, Chen-Tse Chiang, Chin-Lan Jen, Sheng-Nan Lu, Li-Yu Wang, Chien-Jen Chen, Hwai-I Yang
Journal: Journal of Hepatology (2022)
Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results form a genome-wide case-control study
Authors: Stephan Buch, Hamish Innes, Philipp Lutz, Hans Dieter Nischalke, Jacob Nattermann, Jens U. Marquardt, Janett Fischer, Karl Heinz Weiss, Jonas Rosendahl, Astrid Marot, Marcin Krawczyk, Markus Casper, Frank Lammert, Florian Eyer, Arndt Vogel, Silke Marhenke, Johann von Felden, Rohini Sharma, Stephen Atkinson, Andrew McQuillin, Clemens Schafmayer, Christian Strassburg, Heidi Altmann, Stefan Sulk, Veera Raghavan Thangapandi, Mario Brosch, Carolin Lackner, Rudolf E. Stauber, Ali Canbay, Alexander Link, Thomas Reiberger, Mattias Mandorfer, Georg Semmler, Bernhard Scheiner, Christian Datz, Stefano Romeo, Stefano Ginanni Corradini, Luca Valenti, Sascha Müller, Marsha Morgan, Jean-Francois Dufour, Jonel Trebicka, Thomas Berg, Pierre Deltenre, Sebastian Mueller, Jochen Hampe, Felix Stickel
Journal: Journal of Hepatology (2022)
Plasma metabolomics and machine learning characterizes metabolite signature capable of segregating patients with poor outcome in pediatric cirrhosis
Authors: Babu Mathew, Gaurav Tripathi, Vipul Gautam, Akhilesh Saini, Manisha Yadav, Nupur Sharma, Vasundhra Bindal, Bikrant Bihari Lal, Vikrant Sood, Rajeev Khanna, Jaswinder Maras, Seema Alam
Journal: Journal of Hepatology (2022)
Efficacy and safety of ALXN1840 versus standard of care in Wilson disease: primary results from an ongoing phase 3, randomized, controlled, rater-blinded trial
Authors: Karl Heinz Weiss, Michael Schilsky, Anna Czlonkowska, Fred Askari, Aftab Ala, Peter Ferenci, Peter Ott, Dzhamal Abdurakhmanov, Ferenc Szalay, Piotr Socha, Norikazu Shimizu, Jeff Bronstein, Danny Bega, Sihoun Hahn, Eugene Swenson, Yi Chen, Aurelia Poujois
Journal: Journal of Hepatology (2022)
Long-term outcomes associated with task-shifting of HCV treatment by non-specialist providers: five year follow-up from the ASCEND cohort
Authors: Sarah Mollenkopf, Elana Rosenthal, Gebeyehu Teferi, Rachel Silk, Nivya George, Henry Masur, Shyamasundaran Kottilil, Sarah Kattakuzhy
Journal: Journal of Hepatology (2022)
Antibody response to gut microbiome bacteria in human alcoholic liver disease
Authors: Antonella Putignano, Shilpee Sharma, Anaïs Thiriard, Dalila Lakhloufi, Yiwei Jiang, Anne Botteaux, Eric Trépo, Delphine Degré, Christophe Moreno, Thierry Gustot, Arnaud Marchant
Journal: Journal of Hepatology (2022)
Immune responses before and after liver transplantation: a cohort study of the induced immune response
Authors: Dina Leth Møller, Annemette Hald, Andreas Dehlbæk Knudsen, Ranya Houmami, Nicoline Stender Arentoft, Jens D. Lundgren, Allan Rasmussen, Sisse Rye Ostrowski, Susanne Dam Nielsen
Journal: Journal of Hepatology (2022)
Role of Monocyte chemoattractant protein-induced protein 1 in liver fibrosis and activation of hepatic stellate cells
Authors: Natalia Pydyn, Anna Ferenc, Justyna Kadłuczka, Piotr Major, Edyta Kus, Tomasz Hutsch, Andrzej Budzyński, Jolanta Jura, Jerzy Kotlinowski
Journal: Journal of Hepatology (2022)
Analysis of quality of life, hepatic biochemical markers, and sleep in patients with progressive familial intrahepatic cholestasis who had a pruritus response with odevixibat treatment
Authors: Girish Gupte, Richard J. Thompson, Lorenzo D’Antiga, Tassos Grammatikopoulos, Emmanuel Gonzalès, Florence Lacaille, Alain Lachaux, Bertrand Roquelaure, Ulrich Baumann, Elke Lainka, Ekkehard Sturm, Eyal Shteyer, Piotr Czubkowski, Reha Artan, Buket Dalgic, Hasan Ozen, Kathleen M. Loomes, Jennifer M. Vittorio, Saul J. Karpen, Patrick McKiernan, Cara L. Mack, Angelo Di Giorgio, Qifeng Yu, Lise Kjems, Patrick Horn
Journal: Journal of Hepatology (2022)
SIRT5 rs12216101 T &gt; G variant is associated with mitochondrial dysfunction and disease severity in patients with NAFLD
Authors: Federico Salomone, Rosaria Maria Pipitone, Francesco Malvestiti, Paola Dongiovanni, Miriam Longo, Angela Maria Amorini, Alfio Distefano, Giovanni Li Volti, Giuseppe Lazzarino, Ester Ciociola, Grazia Pennisi, Rossana Porcasi, Daniela Cabibi, Antonio Craxi, Anna Ludovica Fracanzani, Luca Valenti, Salvatore Petta, Stefania Grimaudo
Journal: Journal of Hepatology (2022)
Multicenter prospective study for the use of shortened pre-emptive therapy with Glecaprevir/Pibrentasvir (G/P) and Ezetimibe in hepatitis C (HCV) seronegative non-liver solid organ transplant recipients of HCV viremic grafts
Authors: Bashar Aqel, Surakit Pungpapong, Adyr Moss, Rolland Dickson
Journal: Journal of Hepatology (2022)
Fatty acids directly limit mucosal-associated invariant T cell effector function in non-alcoholic fatty liver disease
Authors: Sebastian Deschler, Percy A. Knolle, Katrin Böttcher, Ulrike Bauer, Marc Ringelhan, Jan Boettcher, Lukas Ramsauer, Alexandra Georgieva, Fabian Geisler, Roland M. Schmid, Junika Pohl
Journal: Journal of Hepatology (2022)
Efficacy of avapritinib versus best available therapy in the treatment of advanced systemic mastocytosis
Authors: Andreas Reiter, Jason Gotlib, Iván Álvarez-Twose, Deepti H. Radia, Johannes Lübke, Priyanka J. Bobbili, Aolin Wang, Chelsea Norregaard, Saša Dimitrijevic, Erin Sullivan, Melinda Louie-Gao, Juliana Schwaab, Ilene A. Galinsky, Cecelia Perkins, Wolfgang R. Sperr, Priya Sriskandarajah, Andi Chin, Selvam R. Sendhil, Mei Sheng Duh, Peter Valent, Daniel J. DeAngelo
Journal: Leukemia (2022)

Abstract Advanced systemic mastocytosis (AdvSM) is a rare myeloid neoplasm associated with poor overall survival (OS). This study (NCT04695431) compared clinical outcomes between patients with AdvSM treated with avapritinib in the Phase 1 EXPLORER (NCT0256198) and Phase 2 PATHFINDER (NCT03580655) trials ( N = 176) and patients treated with best available therapy (BAT; N = 141). A multi-center, observational, retrospective chart review study was conducted at six study sites (four European, two American) to collect data from patients with AdvSM who received BAT; these data were pooled with data from EXPLORER and PATHFINDER. Comparisons between outcomes of OS, duration of treatment (DOT), and maximum reduction in serum tryptase were conducted between the treatment cohorts, with adjustment for key covariates. The results indicated that the avapritinib cohort had significantly better survival (adjusted hazard ratio (HR) (95% confidence interval (CI)): 0.48 (0.29, 0.79); p = 0.004) and significantly longer DOT (HR: 0.36 (0.26, 0.51); p &lt; 0.001) compared to the BAT cohort. Additionally, the mean difference in percentage maximum reduction in serum tryptase levels was 60.3% greater in the avapritinib cohort (95% CI: −72.8, −47.9; p &lt; 0.001). With no randomized controlled trials comparing avapritinib to BAT, these data offer crucial insights into the improved efficacy of avapritinib for the treatment of AdvSM.
A novel non-invasive index for the prediction of liver fibrosis in chronic hepatitis B patients with concurrent nonalcoholic fatty liver disease
Authors: Jian Wang, Jiacheng Liu, Yiguang Li, Li Zhu, Minxin Mao, Weimao Ding, Yuanwang Qiu, Chuanwu Zhu, Jie Li, Rui Huang, Chao Wu
Journal: Journal of Hepatology (2022)
Loss of solute carrier family 38 member 4 (SLC38A4) as a driver for the pathogenesis of severe alcoholic hepatitis
Authors: Nchimunya Nelisa Tebeka, Stephen Atkinson, Luke D. Tyson, Josepmaria Argemi, Adam Syanda, Ramon Bataller, Tamir Rashid, Mark Thursz
Journal: Journal of Hepatology (2022)
The First 5 Years of Uterus Transplant in the US
Authors: Liza Johannesson, Elliott Richards, Vikrant Reddy, Jessica Walter, Kim Olthoff, Cristiano Quintini, Andreas Tzakis, Nawar Latif, Paige Porrett, Kathleen O’Neill, Giuliano Testa
Journal: JAMA Surgery (2022)

Uterus transplant is a viable surgical treatment for women affected by absolute uterine-factor infertility, which affects 1 in 500 women.To review transplant and birth outcomes of uterus transplant recipients in the US since the first case in 2016.In this cohort study, 5 years of uterus transplant outcome data were collected from the 3 centers performing uterus transplants in the US: Baylor University Medical Center, Dallas, Texas; Cleveland Clinic, Cleveland, Ohio; and University of Pennsylvania, Philadelphia. A total of 33 women with absolute uterine-factor infertility who underwent uterus transplant between February 2016 and September 2021 were included.Graft survival, live birth, and neonatal outcome.Of the 33 included uterus transplant recipients, 2 (6%) were Asian, 1 (3%) was Black, 1 (3%) was South Asian, and 29 (88%) were White; the mean (SD) age was 31 (4.7) years; and the mean (SD) body mass index (calculated as weight in kilograms divided by height in meters squared) was 24 (3.6). Most uterus transplant recipients (31 of 33 [94%]) had a congenitally absent uterus (Mayer-Rokitansky-Küster-Hauser syndrome), and 21 of 33 (64%) received organs from living donors. Mean (range) follow-up was 36 (1-67) months. There was no donor or recipient mortality. One-year graft survival was 74% (23 of 31 recipients). Through October 2021, 19 of 33 recipients (58%) had delivered 21 live-born children. Among recipients with a viable graft at 1 year, the proportion with a live-born child was 83% (19 of 23). The median (range) gestational age at birth of neonates was 36 weeks 6 days (30 weeks, 1 day to 38 weeks), and the median (range) birth weight was 2860 (1310-3940) g (median [range], 58th [6th-98th] percentile). No congenital malformations were detected.Uterus transplant is a surgical therapy that enables women with uterine-factor infertility to successfully gestate and deliver children. Aggregate data from US centers demonstrate safety for the recipient, living donor, and child. These data may be used to counsel women with uterine-factor infertility on treatment options.