tbuckley/cabot-search huggingface dataset:
A DEGREE FOR LONDON STUDENTS
Journal: BMJ (1903)

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Arzneimittel-Forschung, Aulendorf
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparing the Quality of Diabetes Care by Generalists and Specialists
Journal: Annals of Internal Medicine (2002)

Summaries for Patients15 January 2002Comparing the Quality of Diabetes Care by Generalists and SpecialistsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-2-200201150-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Comparisons of the quality of care that different types of doctors (for example, primary care doctors and specialists) provide for chronic illnesses, such as diabetes, must be done carefully. First, different types of patients may tend to see different types of doctors. For example, older patients or patients with multiple health problems may seek care from primary care doctors, who will care for all of their problems, instead of from endocrinologists, who would care only for the diabetes. In addition, not all doctors in a specialty practice alike. ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Profiling Care Provided by Different Groups of Physicians: Effects of Patient Case-Mix (Bias) and Physician-Level Clustering on Quality Assessment Results.” It is in the 1 January 2002 issue of Annals of Internal Medicine (volume 136, pages 111-121). The authors are S Greenfield, SH Kaplan, R Kahn, J Ninomiya, and JL Griffith.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoProfiling Care Provided by Different Groups of Physicians: Effects of Patient Case-Mix (Bias) and Physician-Level Clustering on Quality Assessment Results Sheldon Greenfield , Sherrie H. Kaplan , Richard Kahn , John Ninomiya , and John L. Griffith Metrics Cited byQuality of Care in Patients with DiabetesRhoda H. Cobin, MD and Helena W. Rodbard, MDQuality of Care in Patients with DiabetesThe Editors 15 January 2002Volume 136, Issue 2Page: I-42KeywordsBlood pressureCholesterolHealth careHealth care qualityHealth care quality assessmentHealth information technologyHemoglobinProteinsRenal diseasesUrine ePublished: 15 January 2002 Issue Published: 15 January 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
From the Alcohol, Drug Abuse, and Mental Health Administration —
Authors: Donald Ian Macdonald
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ex vivo pharmacologic modulation of basophil histamine release in asthmatic patients
Authors: B. Lebel, B. Arnoux, P. Chanez, Y.-H. Bougeard, J. P. Daures, J. Bousquet, A. M. Campbell
Journal: Allergy (1996)

Histamine is one of a range of mediators which play an important role in asthma, and the “releasability” of basophils has been shown to be upregulated in this disease. In vitro, β2-agonists and to a lesser extent corticosteroids have been shown to reduce histamine release. The ex vivo effects of salmeterol and inhaled corticosteroids on histamine release were studied in 78 asthmatic patients with variable disease severity and 20 control subjects. Spontaneous and anti-IgE-induced histamine release was measured in all subjects. Fifteen patients were not receiving any form of treatment, 42 were treated with inhaled corticosteroids, and 21 received inhaled corticosteroids and salmeterol. Seven patients treated with inhaled corticosteroids and seven patients treated with inhaled corticosteroids and salmeterol were tested twice to assess the effect of salmeterol on histamine release. Nine patients treated with inhaled corticosteroids were tested before and after 1 month of salmeterol treatment to determine the possible inhibition by salmeterol. Patients who were treated with inhaled corticosteroids and salmeterol showed significantly lower levels of spontaneous histamine release (median: 2.5%) than untreated (5.2%) and inhaled corticosteroids-treated asthmatics (3.4%). No tachyphylaxis to salmeterol was observed when patients were tested twice at a 3-month interval. This study suggests that salmeterol may have an additive anti-inflammatory effect with inhaled corticosteroids, although this hypothesis must be tested by further studies involving cells obtained by bronchoalveolar lavage and studies with bronchial biopsies.
Abstract B2-25: DNA methylation-dependent transcription regulatory networks elucidate dynamics of transcription regulatory circuitry in cancers
Authors: Yu Liu, Yang Liu, Zhengtao Xiao, Xuerui Yang
Journal: Cancer Research (2015)

Abstract Context-dependent DNA methylation plays a critical role in regulating gene transcription, thereby serving as an important epigenetic marker or regulator in many biological activities such as pluripotency, development, and complex diseases such as cancer. However, previously in most of the de novo reconstructions of cancer type-specific transcription regulatory networks (TRN), DNA methylation has rarely been taken into account as a significant factor in regulating transcription factor activity and controlling gene expression. The present study was set to systematically assess the involvement of DNA methylation in transcription regulatory circuitry in cancer. We took advantages of the multi-dimensional profiling data of DNA methylations and gene expressions in tumor samples of different cancers in The Cancer Genome Atlas (TCGA) consortium, and developed an integrative analysis pipeline based on conditional mutual information theory, to quantify the cooperative regulatory effects of CpG site methylations and transcription factors on gene expressions, in a genome-wide scale. Our analysis showed that DNA methylation and transcription factors indeed control gene expressions often in duet. To map the interplay between these two major defining factors of gene expression, DNA Methylation-dependent Transcription Regulatory Network (MeTRN), the first of its kind, was assembled for each of 19 major cancer types in TCGA. MeTRN provides a comprehensive view specifically on DNA methylation-dependent transcription events in each cancer type, and has been largely validated by public ChIP-seq and DNaseI-seq data. Comparison of these networks across cancer types showed that context-specificity of transcriptional circuits can be largely attributed to the context-dependent nature of DNA methylation patterns. Therefore, by assembling the cooperative effects of transcription factors and DNA methylations on gene transcription, MeTRN recapitulates an epigenetic scheme that implements dynamics of transcription regulatory circuitry across cancers via context-dependent DNA methylation marks. Supported by extensive cross-validations and experimental evidence, this epigenetically marked and dynamic transcription regulatory circuitry serves as a new basis for further mechanistic studies of gene expression dysregulations in cancers. Citation Format: Yu Liu, Yang Liu, Zhengtao Xiao, Xuerui Yang. DNA methylation-dependent transcription regulatory networks elucidate dynamics of transcription regulatory circuitry in cancers. [abstract]. In: Proceedings of the AACR Special Conference on Computational and Systems Biology of Cancer; Feb 8-11 2015; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(22 Suppl 2):Abstract nr B2-25.
Removal of the Ovaries, etc., in Public Institutions for the Insane.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diving Medicine
Authors: Alfred A. Bove
Journal: American Journal of Respiratory and Critical Care Medicine (2014)

Exposure to the undersea environment has unique effects on normal physiology and can result in unique disorders that require an understanding of the effects of pressure and inert gas supersaturation on organ function and knowledge of the appropriate therapies, which can include recompression in a hyperbaric chamber. The effects of Boyle's law result in changes in volume of gas-containing spaces when exposed to the increased pressure underwater. These effects can cause middle ear and sinus injury and lung barotrauma due to lung overexpansion during ascent from depth. Disorders related to diving have unique presentations, and an understanding of the high-pressure environment is needed to properly diagnose and manage these disorders. Breathing compressed air underwater results in increased dissolved inert gas in tissues and organs. On ascent after a diving exposure, the dissolved gas can achieve a supersaturated state and can form gas bubbles in blood and tissues, with resulting tissue and organ damage. Decompression sickness can involve the musculoskeletal system, skin, inner ear, brain, and spinal cord, with characteristic signs and symptoms. Usual therapy is recompression in a hyperbaric chamber following well-established protocols. Many recreational diving candidates seek medical clearance for diving, and healthcare providers must be knowledgeable of the environmental exposure and its effects on physiologic function to properly assess individuals for fitness to dive. This review provides a basis for understanding the diving environment and its accompanying disorders and provides a basis for assessment of fitness for diving.
Abstract 1068: Socs3 deficiency in myeloid cells promotes prostate tumor development
Authors: Hao Yu, Hongwei Qin
Journal: Cancer Research (2014)

Abstract Suppressor Of Cytokine Signaling (SOCS) proteins are negative regulators of the JAK/STAT pathway, and have been implicated as functioning as tumor suppressors, particularly SOCS3. We have previously demonstrated that specific deletion of SOCS3 in myeloid cells leads to heightened activation of STAT3 and downstream STAT3 target gene expression. STAT3 activation has been strongly implicated in contributing to prostate cancer progression and metastasis. STAT3 signaling in myeloid cells has been demonstrated to attenuate anti-tumor immunity. Thus, we evaluated the impact of SOCS3 deletion in myeloid cells in a murine prostate tumor model. We demonstrate that prostate tumor growth is significantly enhanced in myeloid-specific SOCS3-deficient mice, which correlates with elevated levels of Myeloid Derived Suppressor Cells (MDSC) in both the spleen and tumor microenvironment, and less CD8+ T-cell infiltration in tumors. Furthermore, SOCS3-deficient bone-marrow-derived mononuclear cells exhibit heightened STAT3 activation and are preferentially differentiate into MDSC phenotype. Importantly, we identify granulocyte-colony stimulating factor (G-CSF) as a critical factor secreted by the prostate tumor microenvironment that promotes development of Gr-1+CD11b+ cells via a STAT3-depentent pathway. Abrogation of tumor-derived G-CSF reduced the proliferation and accumulation of Gr-1+CD11b+ cells and inhibited prostate tumor growth. Therefore, the tumor-derived cytokine, G-CSF, is a prospective candidate upstream of the STAT3/SOCS3 pathway in MDSC differentiation from the bone marrow. These findings highlight the critical function of SOCS3 as a negative regulator of MDSC development and function, which may contribute to tumor suppressor attributer of SOCS3. Citation Format: Hao Yu, Hongwei Qin. Socs3 deficiency in myeloid cells promotes prostate tumor development. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1068. doi:10.1158/1538-7445.AM2014-1068
Low Rate of HIV Viral Suppression
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Authors' reply
Authors: M Thomas, I D Pavord
Journal: Thorax (2009)

Role of breathing exercises in hyperventilating subjectsThomas and colleagues reported breathing training leading to improvements in asthmaspecific health status and other patientcentred measures. 1These included Asthma Quality of Life Questionnaire (AQLQ) scores, Hospital Anxiety and Depression (HAD) anxiety, HAD depression, Nijmegen scores and Asthma Control Questionnaire (ACQ) scores.The significant improvement in all the above stated scores except the last one at 6 months after the intervention could be due to a few inherent biases.This was discussed in our weekly journal club.First, most of the population studied were hyperventilating subjects, as evidenced by the mean Nijmegen scores in both groups of .23.Breathing training might therefore have helped these hyperventilating subjects.Second, as stated in the article, most subjects with chronic disease would like to try alternative forms of treatment. 2If this ''alternative form'' was mentioned during the invitation to take part in the study (which is not stated in the article), then all the subjects could have been self-motivated, which is not representative of the general population and hence the results cannot be generalised.Last, the subjects who underwent breathing training were encouraged to do the breathing exercises throughout the 6-month period whereas the control group had three sessions of asthma education with no such ongoing ''controlling effect''.A significant improvement in forced expiratory volume in 1 s and a significant fall in exhaled nitric oxide 1 month after the intervention in the control group shows the beneficial effect of patient education.Hence, effective pharmacotherapy with asthma education continues to be the core of asthma treatment.The role of breathing training is possibly present in subjects who have a tendency to hyperventilate, which need not be due just to asthma but to any cause.
A Diabetes Survey: Report of a Working Party Appointed by the College of General Practitioners
Authors: J Malins, M Fitzgerald, R Gaddie, K Cross, Miss Wall, A Allen, Amy Allen, D Crombie, L Gathergood, C Green, R Morgan, A Pearce, L Pike, R Pinsent, G Thorpe
Journal: BMJ (1962)

Much information is available on the incidence of glycosuria in selected populations-derived, for instance, from recruits to the armed Forces, those volunteering to have urine tests during " diabetes weeks," and women during pregnancy-but the great difficulty of ensuring a complete survey on any large and representative sample of a whole population has resulted in a shortage of information in this broader field.Wilkerson and Krall (1947) in Oxford, Massachusetts; Kenny et al. ( 1951) and Kenny and Chute (1953) in Canada; Schliack and Weuffen (1960) in East Germany; Redhead (1960) and Walker and Kerridge (1961) in Great Britain have conducted surveys in which an attempt was made to ensure complete cover of a representative sample of the population.Actually, the proportions of the population surveyed ranged from 54 to 81% only (Table I).Redhead used a constructed sample of his own practice.TABLE I.-Resiults of Previoius Diabetes Surveys Wilkerson and Kral (1947)
Intravenous Hyperalimentation
Authors: David V. Habif
Journal: JAMA (1973)

This book collects the papers and discussions presented at a conference held Nov 30, 1970, at the Brooke Army Medical Center, San Antonio, Tex. The majority of the talks dealt with foodstuff and energy metabolism in normal, malnourished, and traumatized states. Most of the data discussed had already been recorded in greater depth in the literature, but the essential facts were presented nicely. A thorough knowledge of the metabolism of carbohydrate, fat, and protein in various states of nutrition and trauma serves as a background for understanding the value and limitations of intravenous hyperalimentation. During the past five years, intravenous nutrition with large amounts of dextrose and protein hydrolysate or amino acids has been used extensively in the United States. We still lack precise indications for its use; we have not as yet been able to avoid or successfully treat all of the technical septic and metabolic complications; we do
Erratum: Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation
Authors: M.P. Schön, T. Krahn, M. Schön, M.-L. Rodriguez, H. Antonicek, J.E. Schultz, R.J. Ludwig, T.M. Zollner, E. Bischoff, K.-D. Bremm, M. Schramm, K. Henninger, R. Kaufmann, H.P.M. Gollnick, C.M. Parker, W.-H. Boehncke
Journal: Nature Medicine (2002)
Abstract 293: MicroRNA-532 Protects the Heart in Acute Myocardial Infarction by Repressing a Positive Regulator of Endothelial-to-mesenchymal Transition, Prss23
Authors: Ahmed S Bayoumi, Jian-Peng Teoh, Il-man Kim
Journal: Circulation Research (2017)

Aims: Acute myocardial infarction (MI) leads to cardiac remodeling and development of heart failure. Insufficient myocardial capillary density after MI is considered a critical determinant of this process. MicroRNAs (miRs), negative regulators of gene expression, have emerged as important players in MI. We previously showed that miR-532-5p (miR-532) is upregulated by the β-arrestin-biased β-adrenergic receptor antagonist (β-blocker) carvedilol, which activates protective pathways in the heart independent of G protein-mediated second messenger signaling (Figure A-C). Here, we hypothesize that β2-adrenergic receptor/β-arrestin-responsive miR-532 confers cardioprotection against MI. Methods and Results: Using cultured cardiac endothelial cell (CEC) and in vivo approaches, we show that CECs lacking miR-532 exhibit increased transition to a fibroblast-like phenotype via endothelial-to-mesenchymal transition (EndMT). We also demonstrate that knockdown of miR-532 in mice causes abnormalities in cardiac structure and function as well as reduces CEC proliferation and cardiac vascularization after MI. Mechanistically, cardioprotection elicited by miR-532 is in part attributed to repression of a positive regulator of maladaptive EndMT, prss23 (a vascular protease serine 23) in CECs (Figure D). Lastly, cardiac expression of miR-532 and prss23 is inversely correlated during MI. Conclusions: In conclusion, these findings reveal a pivotal role for miR-532-prss23 axis in regulating CEC function after MI, and this novel axis could be suitable for therapeutic intervention in ischemic heart disease.