tbuckley/cabot-search huggingface dataset:
PWE-078 A Prospective Controlled Pilot Study of Fecal Microbiota Transplantation for Chronic Refractory Pouchitis
Authors: J Landy, H O Al-Hassi, E R Mann, S T Peake, S D McLaughlin, Z L Perry-Woodford, P J Ciclitira, J Nicholls, S K Clark, S C Knight, A L Hart
Journal: Gut (2013)

<h3>Introduction</h3> Faecal microbiota transplantation (FMT) is an effective therapy for <i>Clostridium difficile</i> and possibly inflammatory bowel diseases (IBD). Published data of FMT for inflammatory bowel diseases are reported in case series and case reports. To our knowledge, there are no controlled studies of FMT for IBD. We aimed to conduct a prospective study of FMT for chronic refractory pouchitis. <h3>Methods</h3> Patients with clinically, endoscopically and histologically confirmed chronic refractory pouchitis; with a pouch disease activity index (PDAI) &gt; 7 were included. Donors were screened by clinical history and serology for HAV, HBV, HCV, HEV, Treponema, HIV, HTLV I/II and stool for M, C+S, C. difficile toxin and parasites. Fresh donor stool was collected within six hours of nasogasric administration of FMT. Stool samples were also collected from patients for analysis of coliform sensitivities before and 4 weeks after FMT. PDAI and Cleveland global quality of life score (CGQoL ) were recorded prior to FMT and four weeks after FMT. <h3>Results</h3> Eight patients with chronic refractory pouchitis who had undergone restorative proctocolectomy for ulcerative colitis underwent FMT. Three patients had ESBL resistant coliforms on stool analysis prior toFMT. Two of these patients demonstrated a change to ciprofloxacin sensitive coliform following FMT. The mean PDAI prior to FMT was 12. The mean CGQoL was 0.45. At 4 weeks following FMT, no patient had achieved a clinical remission (mean PDAI 11). No improvement in CGQoL was seen (mean 0.44). <h3>Conclusion</h3> FMT via nasogastric administration was not effective in achieving clinical remission for chronic refractory pouchitis at 4 weeks after FMT. However, in two patients with ESBL resistant coliform, ciprofloxacin sensitivity was regained following FMT and these patients have subsequently been maintained on ciprofloxacin. This suggests FMT may alter the pouch microbiota. Further molecular microbiological analysis is being undertaken to determine the effect FMT had on these patients’ microbiota. In addition, further studies of FMT are required to assess the effect of different methods of FMT that may be more efficacious for this group of patients. <h3>Disclosure of Interest</h3> None Declared.
Otolaryngology–Head and Neck Surgery
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transactions of the Medical Association of the State of Alabama.
Journal: JAMA (1897)

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Fine Particulate Matter and Polycyclic Aromatic Hydrocarbon Concentration Patterns in Roxbury, Massachusetts: A Community-Based GIS Analysis
Authors: Jonathan I. Levy, E. Andres Houseman, John D. Spengler, Penn Loh, Louise Ryan
Journal: Environmental Health Perspectives (2001)

Given an elevated prevalence of respiratory disease and density of pollution sources, residents of Roxbury, Massachusetts, have been interested in better understanding their exposures to air pollution. To determine whether local transportation sources contribute significantly to exposures, we conducted a community-based pilot investigation to measure concentrations of fine particulate matter (particulate matter < 2.5 microm; PM(2.5)) and particle-bound polycyclic aromatic hydrocarbons (PAHs) in Roxbury in the summer of 1999. Community members carried portable monitors on the streets in a 1-mile radius around a large bus terminal to create a geographic information system (GIS) map of concentrations and gathered data on site characteristics that could predict ambient concentrations. Both PM(2.5) and PAH concentrations were greater during morning rush hours and on weekdays. In linear mixed-effects regressions controlling for temporal autocorrelation, PAH concentrations were significantly higher with closer proximity to the bus terminal (p < 0.05), and both pollutants were elevated, but not statistically significantly so, on bus routes. Regressions on a subset of measurements for which detailed site characteristics were gathered showed higher concentrations of both pollutants on roads reported to have heavy bus traffic. Although a more comprehensive monitoring protocol would be needed to develop robust predictive functions for air pollution, our study demonstrates that pollution patterns in an urban area can be characterized with limited monitoring equipment and that university-community partnerships can yield relevant exposure information.
Racial Disparity in Breastfeeding
Journal: JAMA (2014)

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Recognition of mental distress and diagnosis of mental disorder in primary care
Authors: S. F. Jencks
Journal: JAMA (1985)

Data from the National Ambulatory Medical Care Survey show that the majority of psychotropic drugs and "psychotherapy/therapeutic listening" provided to adults in office-based primary care are given in visits during which no diagnosis of mental disorder is recorded. This finding is not explained either by a general tendency of surveyed physicians to record drug treatment without an appropriate diagnosis or by management of specific nonmental disorders with mental treatments. Patients who receive treatment without diagnosis tend to be older, established patients with established diagnoses who see the physician for a shorter visit and are more likely to have a follow-up appointment. The data do not provide evidence as to whether mental treatment without mental diagnosis results from inadequacies in the current diagnostic system, inadequacies of physician knowledge and skills, or other factors. Further clarification of this issue will require new research models. (<i>JAMA</i>1985;253:1903-1907)
Coccidioidomycosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Surgery (2019)

Laparoscopic Gastrectomy After Neoadjuvant Chemotherapy 1093The safety and efficacy of laparoscopic gastrectomy after neoadjuvant chemotherapy remain unclear.Li and colleagues conducted a randomized clinical trial of 96 patients receiving neoadjuvant chemotherapy for locally advanced gastric cancer at Peking University Cancer Hospital and Institute in Beijing, China.Results suggest that patients may benefit from laparoscopic gastrectomy, in that they had lower postoperative complication rates and better adjuvant chemotherapy tolerance.
Human Protozoology.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coronary Disease Among United States Soldiers Killed in Action in Korea
Authors: William F. Enos, Robert H. Holmes, James Beyer
Journal: JAMA (1986)

The purpose of this paper is to describe and analyze the gross lesions found in the coronary arteries of United States soldiers killed in action in Korea. The histology will be discussed in detail in a subsequent paper as will such pertinent data as race, body build, and personal habits. <h3>MATERIAL</h3> Recently 300 autopsies were performed on United States battle casualties in Korea. Most of these soldiers were killed in action or suffered accidental death in front line areas. The coronary arteries were carefully dissected in all cases. No case in which there was known clinical evidence of coronary disease was included in this series. The average age in 200 cases was 22.1 years. The ages in the first 98 cases were not recorded except that the oldest patient was 33. In the entire series, the youngest recorded age was 18 and the oldest 48. <h3>FINDINGS</h3> In 77.3% of the
RESPIRATORY ANAPHYLAXIS
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Drugs causing weight gain.
Journal: BMJ (1974)

suggested that the British Diabetic Association criteria11 are applicable to pregnant women.Criteria for the intravenous test during pregnancy have been published by F. A. Silverstone and colleagues.'2The case for screening in pregnancy rests not only on the chance of discovering gestational diabetes but also on that of finding chemical or overt diabetes.Only a postpartum test can confirm that the diabetes is gestational.Apart from any risk in the current pregnancy, gestational diabetes means that the woman has a greater risk ofdeveloping permanent diabetes, and it is an indication for an early glucose tolerance test in subsequent pregnancies.
The Dueling Diagnoses of Darwin
Authors: A. G. Gordon
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Drs Barloon and Noyes<sup>1</sup>excluded Meniere disease in Darwin in the alleged absence of aural fullness, tinnitus, or hearing loss. However, there is overwhelming evidence for subclinical Meniere disease with a very plausible cause: acoustic trauma. Before 1861 Meniere disease was "gastric vertigo" (Charcot<sup>2</sup>) or "suppressed gout,"<sup>3</sup>Darwin's 1848 diagnosis.<sup>4</sup> Perceived pressure in the head or ear is often ignored by patients and physicians.<sup>2,5</sup>For example, Van Gogh<sup>2</sup>had "the profound feeling at times that his mind was a turbid pool" and "a feeling of emptiness or fatigue in the head." Hughlings-Jackson<sup>3</sup>reported that after firing 2 shots at a bird, a fit young surgeon had chronic Meniere symptoms<sup>3</sup>"with a full heavy dull feeling in my head, and it seems to deaden my intellect, and render me powerless for consecutive thought." Darwin<sup>4</sup>wrote, "I have now been six days with
Low Back Pain
Authors: John L. Wright
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erythropoietin (EPO) has no direct effect on tumor growth or angiogenesis in animal models
Authors: M. E. Hardee, J. P. Kirkpatrick, S. Snyder, S. Shan, Z. Vujaskovic, Z. N. Rabbani, M. W. Dewhirst, K. L. Blackwell
Journal: Journal of Clinical Oncology (2004)

9530
Error in Figure Data
Journal: JAMA Cardiology (2018)

Jawad H. Butt, MD; Ying Xian, MD, PhD; Eric D. Peterson, MD, MPH; Peter Skov Olsen, MD, DMSc; Rasmus Rørth, MD; Anna Gundlund, MD; Jonas B. Olesen, MD, PhD; Gunnar H. Gislason, MD, PhD; Christian Torp-Pedersen, MD, DMSc; Lars Køber, MD, DMSc; Emil L. Fosbøl, MD, PhD
NEWS FROM GERMANY
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tumor-infiltrating lymphocytes (TILs) density as prognostic determinant in stage II colorectal cancer
Authors: C.L.o. Nigro, A. Comino, D. Vivenza, C. Granetto, M. Ferrero, L. Lattanzio, C. Varamo, V. Ricci, M.C. Merlano
Journal: Annals of Oncology (2016)
Troubled Children
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A3.6 Comparative Analysis of the Therapeutic Potential of Inducible Treg Cell PopulAtions in Experimental Model of Arthritis
Authors: Julie Quentin, Delphine Martire, Anne-Laure Mausset-Bonnefont, Hélène Asnagli, Nathalie Belmonte, Arnaud Foussat, Christian Jorgensen, Rita Vincente, Pascale Louis-Plence
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background and Objectives</h3> Adoptive cell transfer of Treg cells is a promising approach to restore tolerance in autoimmune disease. However the various type of Tregs, their doses of injection and their in vivo-suppressive mechanism need to be precisely define to clearly establish which Tregs will be able to dampen efficiently the immune response in the various settings. In our study, we compared the therapeutic potential of IL10-secreting Tregs: Tr1 and CD49b-induced Tregs and CD25<sup>+</sup>FoxP<sup>+</sup> Tregs. These two Treg populations share several phenotypic markers as well as immunosuppressive properties. In the present study we perform adoptive cell transfer experiments of the various inducible Treg cells in order to compare their impact on the immune response. <h3>Materials and Methods</h3> CD49b Treg cells were generated in naive mice following repetitive injections of immature dendritic cells (DC). Cell sorting experiments were realised to obtain 98% pure CD49b T cells and CD25<sup>+</sup> cells. Collagen type II (bCII) specific Tr1 clones were obtained from TCR transgenic mice and expanded in vitro. Selected clones showed in vitro antigen specificity, Tr1 cytokine profile and IL10- and TGFβ-dependent suppressive activity. Several doses of CD49b or Tr1 cells were injected i.v. at day 28 in established collagen-induced arthritis. Clinical signs of arthritis were scored, as well as the in vivo impact on the proliferation of Teffector cells and the maturation of DC. <h3>Results</h3> We defined for both Treg cell populations the most efficient dose in curative settings experiments. One single dose of 3 × 10<sup>6</sup> or 1 × 10<sup>6</sup> of Tr1 cell administration could reduce the incidence and severity of CIA. Interestingly, higher dose of 10M of Tr1 cells did not improve the disease. In the same manner, the dose of 10<sup>5</sup> CD4CD49b<sup>+</sup> cells reverse clinical symptom with a lack of efficacy of higher doses. We demonstrated following injection of Treg cells a clear impact on the proliferation of the effector cells in vivo. <h3>Conclusions</h3> Our results suggest that even if the Treg cells present some similarities, we need to precisely define the dose and type of Treg that will be efficient in each experimental setting. We provide also a comparative analysis of the in vivo mechanism responsible of the protection of the various subtypes of Treg cells.