tbuckley/cabot-search huggingface dataset:
Highlights of This Issue
Journal: Clinical Cancer Research (2015)

TCR-gene T-cell therapy has been studied in refractory melanoma and sarcoma patients, and the regimens usually include lymphodepleting preconditioning. Kageyama and colleagues treated 10 MAGE-A4+ recurrent esophageal cancer patients with wild-type TCR-gene transduced T-cell transfer. They show that the transferred T cells persisted long, trafficked to tumor sites, and maintained tumor-specific reactivity and that 3 of 10 patients who had minimal disease long-remained free from disease progression. All the patients did not encounter any serious toxicity. Wild-type TCRs with physiologically high avidity may represent a safe approach in clinical use.The development of novel anticancer agents is central to improving cancer treatment. Lolkema and colleagues present a study exploring a novel selective C-Met inhibitor and report unexpected renal toxicity in humans. Extensive preclinical analysis showed that species-specific metabolism of quinoline ring structures causes the renal toxicity. This integrated clinical and preclinical analysis elucidated the mechanism of toxicity allowing future quinoline ring structure containing drugs to be tested for species specific metabolism.Cell-penetrating peptides represent a promising class of anticancer drugs; however, these agents have had limited applicability because of poor pharmacologic and intracellular delivery properties. Hasegawa and colleagues report that these challenges can be circumvented when targeting the widely overexpressed MUC1-C oncoprotein by encapsulating the GO-203 inhibitor peptide in novel biodegradable PLA-PEG-PPG-PEG tetrablock nanoparticles (NPs). They show that these NPs are highly effective for inhibiting MUC1-C by the sustained intracellular delivery of GO-203 in diverse carcinoma cells growing in vitro and in vivo. This NP-based approach may be functional for the targeting of other intracellular oncoproteins with peptide drugs.Crizotinib showed marked antitumor activity against ROS1-rearranged NSCLC. Despite the efficacy of crizotinib, development of resistance is inevitable. Song and colleagues discerned the mechanisms of crizotinib resistance in ROS1-rearranged NSCLC using samples from two patients and crizotinib-resistant cell lines. ROS1 kinase mutations (G2032R and L2155S), EGFR activation, and epithelial-to-mesenchymal transition were associated with acquired crizotinib resistance. Secondary ROS1-mutant NSCLC cells were sensitive to foretinib. In addition, EGFR/ROS1-activated NSCLC cells were inhibited by irreversible EGFR inhibitors. These might define subsequent treatment strategies in patients with ROS1-rearraged NSCLC who showed acquired resistance to crizotinib.
Spontaneous Bacterial Peritonitis Caused by a Viridans Streptococcus or Neisseria perflava
Authors: Jack D. McCue
Journal: JAMA (1983)

Eight patients had nine episodes of presumed spontaneous bacterial peritonitis (SBP) caused by commensal bacteria that usually inhabit the oropharynx, including<i>Neisseria perflava</i>and the viridans streptococci<i>Streptococcus milleri</i>,<i>Streptococcus mitis</i>, and<i>Streptococcus sanguis</i>. Nonpurulent ascites (ascitic fluid WBC count, &lt;1,000/cu mm) was present in four episodes, possibly caused by either bacterial colonization or early peritonitis; purulent ascites was present in five episodes. None died of their infection, and three episodes remitted without treatment. Poor condition of gums and teeth may play a pathogenic role in SBP caused by these bacteria. (<i>JAMA</i>1983;250:3319-3321)
Oxygenation Status of a Transplantable Tumor During Fractionated Radiation Therapy&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: van Putten, L. M., Kallman, R. F.
Journal: JNCI Journal of the National Cancer Institute (1968)

Journal Article Oxygenation Status of a Transplantable Tumor During Fractionated Radiation Therapy Get access L. M. van Putten, L. M. van Putten Department of Radiology, Stanford University School of Medicine, Palo Alto, California 94304 Search for other works by this author on: Oxford Academic PubMed Google Scholar R. F. Kallman R. F. Kallman Department of Radiology, Stanford University School of Medicine, Palo Alto, California 94304 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 40, Issue 3, March 1968, Pages 441–451, https://doi.org/10.1093/jnci/40.3.441 Published: 01 March 1968 Article history Received: 03 January 1967 Accepted: 20 September 1967 Published: 01 March 1968
Jogging Your Way Through CPR
Authors: Joseph A. Stirt
Journal: JAMA (1983)

<h3>To the Editor.—</h3> The rate of cardiac compression during cardiopulmonary resuscitation (CPR) has been prescribed in published standards.<sup>1</sup>A rescuer working alone is told to compress the chest at a rate of 80 compressions per minute, for a total of 15 compressions, before giving two breaths. When two rescuers are working together, the suggested compression rate is 60 beats per minute. To help the rescuers maintain these rates, they are taught to count aloud. At the more rapid rate, the rescuer enunciates: "1 and 2 and 3...." When two work together, one calls out, "1, 1,000; 2, 1,000; 3, 1,000...." Under the best of circumstances, trained rescuers can accurately keep the proper cadence and compress at rates close to ideal. However, at the site of rescue, this is often not so. We have observed rescuers compressing the chest at almost twice the ideal rate early in resuscitations. If spontaneous
Investor-related academic health center: an 'uncertain courtship'?
Authors: Marsha F. Goldsmith
Journal: JAMA (1985)

Preserving M. more than two millenia of medical tradition in today's competitive health care market-place is the challenge now faced by university-affiliated physicians and hospital administrators. To consider what many find the most expedient approach to the problem, a "Conference on the Investor-Related Academic Health Center and Medical Education" was held recently in Phoenix under the sponsorship of the American Medical Association, American Hospital Association, and Association of American Medical Colleges. The event was organized by the AMA's Section on Medical Schools. Co-chairs of the planning committee were John E. Chapman, MD, dean, Vanderbilt University School of Medicine, Nashville, Tenn, and Stanley S. Bergen, Jr, MD, president, University of Medicine and Dentistry of New Jersey, Newark. The meeting's subtitle, "An Uncertain Courtship," seems to characterize a situation in which poor-but-honest nonprofit teaching hospitals are increasingly finding themselves not only succumbing to the blandishments of wealthy, acquisitive investor-owned health care corporations
Subcutaneous lesions and bacteraemia due to <i>Stenotrophomonas maltophilia</i> in three leukaemic patients with neutropenia
Authors: C. MOSER, V. JØNSSON, K. THOMSEN, J. ALBRECTSEN, M.M. HANSEN, J. PRAG
Journal: British Journal of Dermatology (1997)

Subcutaneous lesions were seen in three of 13 neutropenia patients who had Stenotrophomonas (Xanthomonas) maltophilia bacteraemia. The characteristic clinical presentation resembled leukaemic infiltrates, and were different from deep ulcers or subcutaneous nodules caused by Pseudomonas aeruginosa. The three patients had acute leukaemia and were treated with intensive combination chemotherapy. All had previously been treated with broad-spectrum antibiotics, and each patient recovered after proper combination antibiotic treatment given according to sensitivity testing.
Immunization Status of Children of Employees in a Large Corporation
Authors: Jonathan E. Fielding
Journal: JAMA (1994)

<h3>Objective.</h3> —To assess immunization levels for children of employees of a large corporation. <h3>Design.</h3> —A mail survey of a random sample of employees on the immunization history of one child per family. <h3>Setting.</h3> —US employees of Johnson &amp; Johnson. <h3>Participants.</h3> —1500 employees with children born between 1984 and 1991. <h3>Main Outcome Measures.</h3> —Coverage rates for recommended vaccines at different ages up to 6 years. <h3>Main Results.</h3> —Only 45.2% and 55.3% of the study children at ages 2 and 6 years were current for all recommended immunizations (65.1% and 70.3%, respectively, excluding the<i>Haemophilus influenzae</i>type b vaccine). Using the minimum standard required by many states for school entry, the coverage level at age 6 years was 90.4%. Factors associated with higher immunization rates at age 2 years were the corporate health plan (choices), higher pay level, greater parental formal education, white race, and knowing when to initiate immunization. Lower immunization rates at age 2 years were associated with delayed receipt of the first dose of diphtheria, tetanus, and pertussis vaccine, use of city or county clinics, employee-reported barriers of difficulty leaving work, and provider access problems, but not cost of services. After adjusting for the effects of other variables through logistic regression, race, pay level, and plan choice were no longer significant. Modeling with the remaining variables predicted rates of adequate immunization at age 2 years from 15% to 81%. <h3>Conclusion.</h3> —Even in this relatively affluent group with good insurance (including immunizations), preschool immunization rates did not reach public health goals. Changing modifiable factors, such as knowing when to initiate immunization, enabling parents to leave work more easily, and improving provider access, might improve preschool immunization rates. (<i>JAMA</i>. 1994;271:525-530)
Natural Cytotoxicity in Humans: Susceptibility of Freshly Isolated Tumor Cells To Lysis&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn3"&gt;3&lt;/xref&gt;
Authors: Brent M. Vose, Michael Moore
Journal: JNCI Journal of the National Cancer Institute (1980)

The cytotoxic potential of blood lymphocytes from healthy donors was tested against freshly isolated lung cancer cells and the erythroleukemia K562 cell line in short-term 51Cr release assays conducted at an effector:target ratio of 50:1. Most donors exhibited significant activity against K562 cells. By contrast, fresh tumor cells were refractory, only 6 of 30 showing significant cytotoxicity. The low susceptibility of these tumor cells was confirmed in third-party cold inhibition assays in which they interfered minimally with killing of K562 targets under conditions in which unlabeled K562 cells efficiently blocked cytotoxicity. Cells prepared from normal lung tissue and Raji cells also failed to inhibit killing. Although in comparison to the K562 cell line freshly isolated tumor cells were resistant, their susceptibility may not be so low as to be biologically irrelevant, inasmuch as boosting of natural killing activity by interferon induced levels of cytotoxicity against both types of target cell that were unattainable by unstimulated effectors. Interferon-boosted killers were lytic for “normal” lung cells and the Raji cell line.
Ингибиторы протонной помпы: насколько безопасно длительное применение пантопразола?
Authors: Yu.M. Stepanov, I.Ya. Budzak
Journal: GASTROENTEROLOGY (2013)

В статье рассмотрены подходы к лечению кислотозависимых заболеваний, обозначена ключевая роль ингибиторов протонной помпы. Особо рассматривается вопрос безопасности длительного применения ингибиторов протонной помпы, проанализированы результаты исследований их влияния на состояние гастродуоденальной зоны. Подробно рассмотрены результаты исследования, показавшего безопасность 15-летнего постоянного лечения пантопразолом.
In Vitro Modulation of Cisplatin Cytotoxicity by Sparsomycin Inhibition of Protein Synthesis&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Zbigniew Zylicz, D. J. Theo Wagener, Helga van Rennes, Johannes M. C. Wessels, Eppo van der Kleijn, Willem J. de Grip, Leon A. G. M. van den Broek, Harry C. J. Ottenheijm
Journal: JNCI Journal of the National Cancer Institute (1987)

Inhibition of protein synthesis can alter cellular responsiveness to the classical anticancer drugs. The in vitro response of Chinese hamster ovary (CHO) cells to cisplatin with or without sparsomycin (Sm) was studied with the use of [3H]leucine and [methyl-3H]thymidine incorporation and clonogenic assay. Pretreatment of exponentially growing CHO cells with 1 μg Sm/ml for 3 or 5 hours decreased [3H]leucine incorporation by 20% and resulted in significant resistance to cisplatin (P=.005). Sm in a concentration of 10 μg/ml reduced [3H]leucine and [methyl-3H]-thymidine incorporation after 3 hours by 92 and 84%, respectively, and resulted in potentiation of the cisplatin cytotoxicity (P=.004). This effect was the same in the case of nonproliferating cells (P=.005), while protection due to Sm (1 μg/ml) was seen only during cell proliferation. Simultaneous incubation and postincubation with Sm proved to have much less or no potentiating effect on cisplatin. The mechanisms of both protection and potentiation are still not clear, but our data indicate that Sm is a promising drug for further studies on the modulation of the cancer cell response to classical anticancer drugs.
Painful Swelling Over Right Tibia
Authors: Thomas E. Shea
Journal: JAMA (1967)

Dr. S. Boyd Eaton: A 43-year-old construction worker sustained minor trauma to his right tibia 11 months prior to admission to the hospital. He consulted a physician at that time and was assured that there had been no significant bony injury. Despite this he continued to have slight swelling and mild pain at the site of injury. The pain gradually increased in severity over the ensuing months and he again sought medical attention. Physical examination revealed a small hard mass over the anterior region of the tibia about 5 cm below the tibial tubercle. There were no other significant physical findings and the laboratory values were within normal limits. <h3>Discussion</h3> Dr. Laurence L. Robbins: Dr. Weber, how would you interpret this case? Dr. Alfred L. Weber:There is an obvious lytic lesion in the upper shaft of the right tibia, and there is erosion of the anterior cortex on its
Guide to the Study of Animal Parasites.
Journal: JAMA (1930)

of the lens.Care of Preparations.-In cleaning the cover glasses of pre- pared slides be very careful not to exert pressure as the chances xiv in the following pages were worked out long before the binocular dissecting microscopes were invented.Some simple type of dissecting stand, even if only the tripod with a lens which is focussed by screwing up and down in the metal frame can be provided in any laboratory.Skill in dissection of minute objects under the ordinary compound microscope is readily acquired and even today is an essential equipment of the student of zoology.Moreover, every student of the subject should own and habit- ually use a good magnifier, mounted in a folding pocket case.While the higher-priced lenses are of course preferable, very good GUIDE TO THE STUDY OF ANIMAL PARASITES
Conflict of Interest and the Peer Review Process
Authors: M. Therese Southgate
Journal: JAMA (1987)

As it is generally used, the term<i>conflict of interest</i>applies to public officials and means that there is a clash between one's sworn duty to the public interest and one's private financial interest.<sup>1</sup>In recent years, the term has been extended to apply to investigators who report studies in medical journals,<sup>2</sup>and disclosure of possible financial gain by the authors of such studies is now editorial policy for some journals.<sup>2,3</sup>The Journal, for example, requests that each author of a submitted manuscript "list all affiliations with or financial involvement in any organization or entity with a direct financial interest in the subject matter or materials of the research discussed in the manuscript (eg, employment, consultancies, and stock ownership)."<sup>3</sup>DuringThe Journal's review process, all such disclosures are held in confidence by the editors and do not enter into decisions concerning the merits of the
And a Little Child Shall Lead Them
Authors: Samuel Vee
Journal: JAMA (1969)

<h3>To the Editor:—</h3> In discussing the various reports on plasma uric acid concentrations as they relate to achievement and personality traits, you sorrowfully note in your editorial, "Uric Acid and the Psyche" (<b>208:</b>1180, 1969), that "kindergarten pupils have as yet not been investigated." It may cheer you to know that at present we are conducting comparative studies of serum uric acid levels in our regional nurseries and kindergartens, and that we have already submitted preliminary reports to our local bulletin. Our subjects—all boys ages 3 and 4—were graded according to (1) intelligence, (2) aggressiveness, and (3) competitiveness. Much to our surprise, intelligence as measured by the standard IQ tests, did not correlate significantly with uric acid levels. But a marked positive correlation was found between the latter and aggressiveness, as estimated by the pugnacity index (PI). Little bullies, who excelled in shinkicking and nose-punching, had serum uric acid concentrations
Editorial board and contents
Authors: Peter Keightley, Brian Charlesworth, Kelly Nikolaidou, Kathy Barrett, Qun Pan, Malina Bakowski, Quaid Morris, Wen Zhang, Brendan Frey, Timothy Hughes, Benjamin Blencowe, Eli Eisenberg, Sergey Nemzer, Yaron Kinar, Rotem Sorek, Gideon Rechavi, Erez Levanon, Kenneth Weiss, Galina Glazko, Eugene Koonin, Igor Rogozin, Jason Johnson, Stephen Edwards, Daniel Shoemaker, Eric Schadt, Avril Kennan, Aileen Aherne, Pete Humphries, Peik Haugen, Dawn Simon, Debashish Bhattacharya, Keith Latham Trendsin, Robert Shields, Treasa Creavin, Karl Smart, Manager Moulton, P Borst, H Horvitz, E Meyerowitz, S Moreno, D Sherratt, J Claycomb, T Orr-Weaver, M Schuler, D Green, A Bergemann, F Cole, K Hirschhorn, M Wilkinson, Geraldine Woods
Journal: Trends in Genetics (2005)
RE: MEDICAL LICENSURE
Authors: Rhett McMahon
Journal: JAMA (1967)

The Federation of State Medical Boards of the United States takes pleasure in once again praising the AMA Council on Medical Education for its yearly report on medical licensure. The annual State Board Number is eagerly awaited for its usual comprehensive coverage of the field and the valuable factual and statistical data herein contained. The member boards, as well as the profession at large, are greatly indebted to the Council for this compendium of ready and accurate reference material. The Federation has been in the past, and will continue to be in the future, greatly concerned with the problems of reciprocity and endorsement of medical credentials among the several jurisdictions and will continue to promote the concept of universal endorsement. Such a concept is only possible when levels of examination and licensure in each jurisdiction meet uniformly high standards. These standards are the constant goal of the Federation through the
Current Medical Literature
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Jogging and Foot Problems
Authors: Murray S. Hoffman
Journal: JAMA (1969)

<h3>To the Editor:—</h3> As a cardiologist, my interest in jogging relates to the cardiovascular effects of endurance exercise. Prompted by the letter entitled "Joggers' Heel" by Irwin M. Siegel, MD (<b>206</b>:2899, 1968), I would like to comment on the feet of the joggers. Heel pad discomfort, secondary to a jogging program, can occur, as Dr. Siegel points out. In regard to the comment that patients were advised to change from jogging to sprinting, which involves running on the ball of the foot, sprinting is not entirely innocuous and the syndrome, "sprinter's foot," is as severe as "jogger's heel." My wife and I, as co-chairmen of the Colorado Heart Association Preventive Cardiology-Exercise Committee, have organized a pilot jogging program. We have at least one well-documented case of "march" fracture occurring in a jogger who preferred to sprint, using the ball of his foot rather than a heel-toe gait. Other very
Pappenheimer Bodies and Spuriously Elevated Platelet Counts
Authors: E. C. Wilson, A. A. Geddie, E. P. Orringer, S. A. Stass
Journal: JAMA (1981)

<h3>To the Editor.—</h3> Since the advent of automated instrumentation, spurious platelet counts have become more frequent. There have been previous reports of spuriously elevated platelet counts using electro-optical counters. The causes for these spuriously elevated counts include Howell-Jolly bodies, cytoplasmic fragments, nucleated erythrocytes, leukocytes, Heinz bodies, malarial parasites, and aggregated erythrocyte stroma secondary to surface antibodies or agglutinating paraproteins.<sup>1-4</sup>Pappenheimer bodies' are seen in several diseases, including sideroblastic anemia, hemolytic anemias,and sickle cell disease. They are also seen in splenectomized patients and have been previously reported in one patient as a cause of spurious platelet counts.<sup>5</sup>We report two additional cases in which a spurious platelet count was associated with Pappenheimer bodies, suggesting that it may be a more important cause of spurious platelet counts than previously realized. <h3>Report of Cases.—</h3> Case1.—A 22-year-old man with Hodgkin's disease after a splenectomy had a platelet count of
The American Pocket Medical Dictionary.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal