AB0634 BASELINE CLINICAL – EPIDEMIOLOGICAL CHARACTERISTICS OF THE PATIENTS IN THE IMMex COHORT
Authors: F. M. Bravo Rojas, M. Ocampo Torres, A. Ramirez Pérez, M. Vázquez Zaragoza, R. Catana Hernández, A. Martínez Badajoz, J. Hernandez Rivera
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease with a wide clinical and evolutionary spectrum. The correct classification and study of the behavior of this type of population helps to constantly improve the approach and prognosis of patients with this disease. <h3>Objectives</h3> Describe the clinical and epidemiological characteristics of patients with SLE included in a cohort in Mexico. <h3>Methods</h3> Retrospective descriptive observational study based on the clinical-epidemiological historical review on the day of inclusion in the LUPUS-IMMex registry. Normality tests were applied, the frequencies and percentages were calculated for the categorical variables and the means with their standard deviation or medians with interquartile range (IQR) for the continuous variables depending on their distribution. A comparison of compliance with diagnostic scores was made according to three classification criteria (ACR 1997, SLICC 2012 and EULAR 2019) according to the manifestations of each patient at the time of incorporation into the cohort. <h3>Results</h3> 121 patients with a diagnosis of SLE according to the 2019 EULAR (European League Against Rheumatism) criteria were included, a review of records from the period 2006 to 2022 was carried out. They were 33 years old (IQR 26–41), 81% were female, 87.6% came from the metropolitan area, 49.1% with a basic educational level. Median age at diagnosis 28 years (IQR 23-37). The time of evolution of the disease until admission to the registry was 3 years (IQR 1-5). 17.48% reported a family history of autoimmune diseases and 27.86% presented concomitant allergies to some drug. The patients underwent a comparison of the classification criteria at the first medical care contact, where it was found that 81.81% met the lupus criteria according to ACR, 94.21% by SLICC and 100% by EULAR. Regarding clinical manifestations, the presence of joint alterations was the most frequent, being present in 61.48% of the patients at the time of diagnosis, followed by mucocutaneous manifestations in 57.38%, hematological manifestations in 49.18%, renal manifestations in 45.90%, fever in 24.59%, serous in 21.31% and lastly neuropsychiatric manifestations in 4.92%. The presence of hypocomplementemia was the most frequent data (72.12%) followed by SLE-specific antibodies and finally antiphospholipid antibodies. <h3>Conclusion</h3> Patients with SLE at our center have both clinical and epidemiological characteristics like those reported by other cohorts. Renal involvement is greater compared to European cohorts but less than that reported in Asian cohorts. The correct and adequate classification of each patient is fundamental to improve the prognosis and correct diagnosis. Although the availability of data in our environment is limited, it is necessary to continue with the constant obtaining of information regarding the subject to be able to be on a par with international cohorts. <h3>Reference</h3> [1]Rúa-Figueroa I, et al. National registry of patients with systemic lupus erythematosus of the Spanish Society of Rheumatology: objectives and methodology. Rheumatol Clinic. 2014 Jan;10(1):17–24. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.