tbuckley/cabot-search huggingface dataset:
Abstract 15836: Blood Pressure Control and Subclinical Left Ventricular Dysfunction in Treated Hypertensive Subjects
Authors: Fusako Sera, Zhezhen Jin, Cesare Russo, Edward S Lee, Joseph E Schwartz, Tatjana Rundek, Mitchell S Elkind, Shunichi Homma, Ralph L Sacco, Marco R Di Tullio
Journal: Circulation (2014)

Background: Blood pressure (BP) control in hypertensive patients is crucial to reducing the risk of future cardiovascular events and heart failure. Left ventricular (LV) global longitudinal strain (GLS) can detect early subclinical cardiac dysfunction, even when LV ejection fraction (EF) is normal, and is an important prognostic indicator. It is not known whether poor BP control is associated with subclinical dysfunction by GLS, and whether ambulatory BP (ABP) is superior to office BP measurements in this regard. Methods: Two-dimensional speckle tracking echocardiography and 24-hour ABP monitoring were performed in 394 treated hypertensive subjects (mean age 72 ± 9 years; 63% women) with LVEF ≥50% from the Cardiovascular Abnormalities and Brain Lesions (CABL) study. Uncontrolled office BP was defined as systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg; uncontrolled ABP as mean 24-hour systolic BP ≥130 mmHg and/or diastolic BP ≥80 mmHg. Abnormal GLS was defined as a value above the 95% percentile of healthy normotensive subjects from the CABL cohort. Results: Office BP was uncontrolled in 188 subjects (47.7%), and ABP in 162 (41.1%). Agreement between these two categorization was low [kappa = 0.16, 95% confidence interval (CI), 0.06-0.26; concordant classification in only 58.4% of subjects]. Subjects with uncontrolled ABP showed significantly worse GLS compared to those with controlled ABP (-16.3 ± 3.0% vs -17.7 ± 2.9%, p&lt;0.0001), whereas GLS was not significantly different between those with uncontrolled vs controlled office BP (-16.8 ± 3.1% vs -17.4 ± 3.0%, p=0.07). After adjustment for pertinent covariates (age, sex, race-ethnicity, body mass index, diabetes mellitus, coronary artery disease and LV mass index), uncontrolled ABP was associated with a higher risk of abnormal GLS (odds ratio = 2.32; 95% CI, 1.33-4.03; p=0.003), while uncontrolled office BP was not (odds ratio = 1.30; 95% CI, 0.76-2.22; p=0.35). Conclusions: Uncontrolled 24-hour ABP is strongly associated with LV subclinical dysfunction in hypertensive subjects with normal LVEF. Assessing BP control with ABP monitoring may refine the risk stratification of treated hypertensive patients for early LV dysfunction.
Abstracts for Society of Nuclear Medicine and Molecular Imaging, Greater New York and New England Chapters, 30th Annual Northeast Regional Scientific Meeting, Stamford CT
Journal: Clinical Nuclear Medicine (2017)

Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Current IssuePrevious IssuesPublished Online First Collections ACNM MeetingsCMECommunication in OrganizationCOVID-19Feedback and RewardsFrom the American College of Nuclear MedicineHighly Cited and Frequently Read ArticlesPlanning and Conducting Meetings EffectivelyQuality and Safety in Health CareRecruitment of New PhysiciansTips for Giving a Memorable PresentationTips for LeadersTips for Physicians in Getting the Right Job ACNM ArticlesACNM Website For Authors Submit a ManuscriptInformation for AuthorsLanguage Editing ServicesAuthor Permissions Journal Info About the JournalEditorial BoardAdvertisingOpen AccessSubscription ServicesReprintsRights and Permissions All Articles Images Videos Podcasts Blogs Advanced Search
Low-Dose Interferon-α in Chronic Myeloid Leukemia
Authors: Jill R. Schofield
Journal: Annals of Internal Medicine (1995)

Letters1 May 1995Low-Dose Interferon-α in Chronic Myeloid LeukemiaJill R. Schofield and William A. RobinsonJill R. SchofieldUniversity of Texas M.D. Anderson Cancer Center, Houston, TX 77030. University of Colorado Health Sciences Center, Denver, CO 80262.Search for more papers by this author and William A. RobinsonUniversity of Texas M.D. Anderson Cancer Center, Houston, TX 77030. University of Colorado Health Sciences Center, Denver, CO 80262.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-9-199505010-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank Drs. Talpaz and Kantarjian for their comments and questions about our recent article on low-dose interferon-α therapy for chronic myeloid leukemia [1]. The unpublished results they cite are better than their previously published data [2, 3] and those of other groups that used similar interferon-α dosing schedules [1]. This includes the most recently published reports of randomized trials by the Italian Cooperative Study Group on Chronic Myeloid Leukemia [4] and by the German Chronic Myeloid Leukemia Group [5]. We are uncertain whether the data cited in their letter are from their original report or from an ...References1. Schofield JR, Robinson WA, Murphy JR, Rovira DK. Low doses of interferon-α are as effective as higher doses in inducing remissions and prolonging survival in chronic myeloid leukemia. Ann Intern Med. 1994; 121:736-44. Google Scholar2. Talpaz M, Kantarjian HM, McCredie K, Keating MJ, Trujillo J, Gutterman J. Clinical investigation of human α interferon in chronic myelogenous leukemia. Blood. 1987; 69:1280-8. Google Scholar3. Talpaz M, Kantarjian HM, Kurzrock R, Trujillo JM, Gutterman JU. Interferon α produces sustained cytogenetic responses in chronic myelogenous leukemia. Ann Intern Med. 1991; 114:532-8. Google Scholar4. The Italian Cooperative Study Group on Chronic Myeloid Leukemia. Interferon α-2A as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia. N Engl J Med. 1994; 330:820-5. Google Scholar5. Hehlmann R, Heimpel H, Hasford J, Kolb HJ, Pralle H, Hossfeld DK, et al. Randomized comparison of interferon α with busulfan and hydroxyurea in chronic myeloid leukemia. Blood. 1994; 84:4064-77. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Texas M.D. Anderson Cancer Center, Houston, TX 77030. University of Colorado Health Sciences Center, Denver, CO 80262. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1995Volume 122, Issue 9Page: 728-729KeywordsChronic myeloid leukemiaCytogeneticsPopulation statisticsRandomized trialsToxicity Issue Published: 1 May 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Causes of, therapies for insomnia, other sleep problems under study
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Influenza: Recommendations for Immunization
Journal: Annals of Internal Medicine (1969)

Diagnosis and Treatment1 September 1969Influenza: Recommendations for ImmunizationU. S. PUBLIC HEALTH SERVICE ADVISORY COMMITTEE ON IMMUNIZATION PRACTICESU. S. PUBLIC HEALTH SERVICE ADVISORY COMMITTEE ON IMMUNIZATION PRACTICESSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-3-617 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe Nationwide epidemic of A2 influenza in the United States in the fall and winter of 1968-1969 showed the impact of a major antigenic change in the prevalent influenza viruses. The Hong Kong strain responsible for the epidemic was the most distinctive variant among A2 influenza viruses identified since initial appearance of the A2 subtype in 1957. The 1968-1969 epidemic highlighted again the problems that are encountered in rapidly developing and producing sufficient quantities of vaccine incorporating a new antigen.Forty-four states reported widespread outbreaks of Hong Kong strain influenza; in six, involvement was less extensive. In all nine geographic... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byComparative Study of Treatment and Performance in Membrane Bioreactor and Sequencing Batch Reactor for Hospital Wastewater in Smart CitiesFluoroaromatic Compounds 1 September 1969Volume 71, Issue 3Page: 617-618KeywordsAntigensFallsInfluenza virusesVaccines ePublished: 1 December 2008 Issue Published: 1 September 1969 PDF downloadLoading ...
Enhancing Professionalism
Authors: Sarena D. Seifer
Journal: Annals of Internal Medicine (1994)

Letters15 October 1994Enhancing ProfessionalismSarena D. Seifer, MD, Edward H. O'Neil, PhD, MPA, and Sunita Mutha, MDSarena D. Seifer, MDSearch for more papers by this author, Edward H. O'Neil, PhD, MPASearch for more papers by this author, and Sunita Mutha, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-8-199410150-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We agree that physicians should embody the values, attitudes, and behaviors that compose Dr. Reynolds' definition of professionalism [1] but question the reliance on historical anecdotes to guide us toward these goals. Doing so risks ignoring the negative aspects of professionalism (for example, elitism and paternalism) [2], misrepresenting the past, and creating unrealistic expectations of today's physicians. In the past, physicians may have viewed medicine as a “calling,” but portraying this as the ideal devalues the personal and professional well-being of individual physicians. Although historical traditions can be instructive, medicine and society are better served by focusing ...References1. Reynolds PP. Reaffirming professionalism through the education community. Ann Intern Med. 1994; 120:609-14. Google Scholar2. Starr P. The Social Transformation of American Medicine. New York: Basic Books; 1982. Google Scholar3. Advisory Panel on Strategic Positioning for Health Care Reform. Academic medicine: the cornerstone of the American health care system. Acad Med. 1993; 68:709-12. Google Scholar4. O'Neil EH. Health Professions Education for the Future: Schools in Service to the Nation. San Francisco: Pew Health Professions Commission; 1993. Google Scholar5. Pew Health Professions Commission. Commission Policy Papers. San Francisco: Pew Health Professions Commission; 1994. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1994Volume 121, Issue 8Page: 625-626KeywordsBehaviorHealth careMedical educationMotivation Issue Published: 15 October 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
New Books
Authors: Howard Frumkin, Lawrence Frank, Richard Jackson, Kenneth Olden
Journal: Environmental Health Perspectives (2005)

The press has devoted considerable recent attention to the built environment and its impact on human health and the quality of life.This interest is fueled largely by the obesity epidemic now pervasive in the United States.In fact, the built environment has become a focus for debate about how to control obesity and related health care costs.The National Institute of Environmental Health Sciences defines the built environment as the buildings, spaces, and products created or modified to accommodate modern human society: residential housing, schools, workplaces, parks, roads, walking and biking trails, and commercial centers.Urban Sprawl and Public Health, a timely publication by highly qualified authors, is another wake-up call about public policy decisions with respect to land use, transportation, and community design that adversely affect our health, civic involvement, and quality of life.Its thesis is that the designs of buildings and communities inhibit physical activity and social interactions and promote sedentary lifestyles and environmental pollution or degradation.The authors provide solutionoriented information to professionals, public officials, business and community leaders, and others who are concerned about protecting the environment and human health.They describe sprawl as the way land is used, the way people travel, and the way cities expand over large geographic areas.Such expansion increases distance between places of interest, makes walking and biking impractical, and increases reliance on automobiles for transportation.Although sprawl appears chaotic, the authors point out that it is well orchestrated and supported by public policy through cheap land, favorable tax codes, zoning regulations,
Poems.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Old Virginia Doctor.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Calcific periarthritis and hemodialysis
Authors: K. S. Mirahmadi
Journal: JAMA (1973)

Nine patients developed an acute, aseptic, periarthritic inflammation associated with soft tissue calcification during treatment with maintenance hemodialysis. Neither crystals of uric acid nor calcium pyrophosphate dihydrate were identified in the joint or tissue fluid. Probably, calcium hydroxyapatite deposits were responsible for the inflammation. The acute attacks were treated with phenylbutazone with generally good clinical response. Recurrent attacks of periarthritis can often be prevented by maintaining normal levels of serum phosphorus with sufficient quantities of phosphate-binding antiacids and greater frequency of adequate dialysis.
Geschlechtskrankheiten.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contents
Authors: Young Hwang, Min Kim, Dai Kim, Younhea Jung, Hae-Young Park, Chan Park, Robert Weinreb, Scassellati Sforzolini, Jason Vittitow, Jeffrey Liebmann, Georgios Kontadakis, Vardhaman Kankariya, Konstantinos Tsoulnaras, Aristofanis Pallikaris, Argyro Plaka, George Kymionis, Nicole Carnt, Dana Robaei, Stephanie Watson, Darwin Minassian, John Dart, Karen Schaal, Philip Rosenfeld, Giovanni Gregori, Zohar Yehoshua, William Feuer, Frank Holz, Pravin Dugel, Georges Weissgerber, Robin Hamilton, Rufino Frcophth, Francesco Bandello, Michael Larsen, Andreas Weichselberger, Andreas Wenzel, Anne Schmidt, Dominik Escher, Laura Sararols, Eric Souied, Anna Zarubina, David Neely, Mark Clark, Carrie Huisingh, Brian Samuels, Yuhua Zhang, Gerald Mcgwin, Cynthia Owsley, Christine Curcio, Claudia Auw-Haedrich, Katarzyna Danielewicz, Pia Mendoza, Thomas Reinhard, Hans Grossniklaus
Journal: Ophthalmology (2016)
When risk factors have little meaning.
Journal: BMJ (1989)

gradually becoming more independent.She spends a lot of time playing alone at home, but increasingly I hear her laughing and playing with her friends.And what of myself?Having spent a lifetime helping others in both physical and spiritual needs, I found I was now the one in need, experiencing the shock and pain of sudden bereavement.It was hard to cope, comfort, and advise and give of myself while having such deep needs of my own.This conflict was worse when one by one people who were themselves bereaved were directed to me for help.
A community-wide streptococcal control project. The Natrona County Primary Prevention Program, Casper, Wyo
Authors: B. Phibbs
Journal: JAMA (1970)

A unique, legally enforced, mass-culture program for detection and treatment of streptococcal pharyngitis has been in effect in Natrona County, Wyoming, since 1954. To evaluate the impact of such a program on the streptococcal milieu, the Streptococcal Disease Section, Ecological Investigations Division, Public Health Service, studied a randomized sample of the children under surveillance. The study revealed an extremely low total streptococcal isolation rate (1.8%), as well as antibody levels consistent with a low level of streptococcal infection. The percentage of students with group A antibody was half that of comparable groups in the region; type-specific antibody titers against six streptococcal types revealed values significantly lower than in uncontrolled schoolchild groups in the Rocky Mountain region. The control measures appear to have altered the streptococcal milieu in a favorable manner.
HEMOCHROMATOSIS
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allergy
Authors: Paul P. VanArsdel
Journal: JAMA (1979)

<h3>Immunoglobulin E</h3> The most important advance in the field of allergy occurred a little more than a decade ago with the identification of a new immunoglobulin class, IgE.<sup>1</sup>Until that time the only method for detecting antibodies in the sera of persons with allergies such as hayfever was by sensitizing nonallergic skin with such sera and then testing the passively sensitized skin with the suspected allergens. The serum concentration of IgE is usually so low (200 ng/mL in adults) that conventional methods usually fail to detect it. Thus, it was necessary to develop a highly sensitive radioimmunoassay method. Specific IgE antibodies to a variety of allergens can also be measured by the radioallergosorbent test (RAST). Diagnostic allergy skin testing, if properly done, should correlate well with the results of the RAST; indeed, the latter is the benchmark for testing the reliability of different skin-testing methods and for standardizing test