tbuckley/cabot-search huggingface dataset:
Protein Structure Prediction: Challenges, Advances, and the Shift of Research Paradigms
Authors: Bin Huang, Lupeng Kong, Chao Wang, Fusong Ju, Qi Zhang, Jianwei Zhu, Tiansu Gong, Haicang Zhang, Chungong Yu, Wei-Mou Zheng, Dongbo Bu
Journal: Genomics Proteomics & Bioinformatics (2023)

Abstract Protein structure prediction is an interdisciplinary research topic that has attracted researchers from multiple fields, including biochemistry, medicine, physics, mathematics, and computer science. These researchers adopt various research paradigms to attack the same structure prediction problem: biochemists and physicists attempt to reveal the principles governing protein folding; mathematicians, especially statisticians, usually start from assuming a probability distribution of protein structures given a target sequence and then find the most likely structure, while computer scientists formulate protein structure prediction as an optimization problem — finding the structural conformation with the lowest energy or minimizing the difference between predicted structure and native structure. These research paradigms fall into the two statistical modeling cultures proposed by Leo Breiman, namely, data modeling and algorithmic modeling. Recently, we have also witnessed the great success of deep learning in protein structure prediction. In this review, we present a survey of the efforts for protein structure prediction. We compare the research paradigms adopted by researchers from different fields, with an emphasis on the shift of research paradigms in the era of deep learning. In short, the algorithmic modeling techniques, especially deep neural networks, have considerably improved the accuracy of protein structure prediction; however, theories interpreting the neural networks and knowledge on protein folding are still highly desired.
Biochemical Assessment of Pheochromocytoma and Paraganglioma
Authors: Graeme Eisenhofer, Christina Pamporaki, Jacques W M Lenders
Journal: Endocrine Reviews (2023)

Abstract Pheochromocytoma and paraganglioma (PPGL) require prompt consideration and efficient diagnosis and treatment to minimize associated morbidity and mortality. Once considered, appropriate biochemical testing is key to diagnosis. Advances in understanding catecholamine metabolism have clarified why measurements of the O-methylated catecholamine metabolites rather than the catecholamines themselves are important for effective diagnosis. These metabolites, normetanephrine and metanephrine, produced respectively from norepinephrine and epinephrine, can be measured in plasma or urine, with choice according to available methods or presentation of patients. For patients with signs and symptoms of catecholamine excess, either test will invariably establish the diagnosis, whereas the plasma test provides higher sensitivity than urinary metanephrines for patients screened due to an incidentaloma or genetic predisposition, particularly for small tumors or in patients with an asymptomatic presentation. Additional measurements of plasma methoxytyramine can be important for some tumors, such as paragangliomas, and for surveillance of patients at risk of metastatic disease. Avoidance of false-positive test results is best achieved by plasma measurements with appropriate reference intervals and preanalytical precautions, including sampling blood in the fully supine position. Follow-up of positive results, including optimization of preanalytics for repeat tests or whether to proceed directly to anatomic imaging or confirmatory clonidine tests, depends on the test results, which can also suggest likely size, adrenal vs extra-adrenal location, underlying biology, or even metastatic involvement of a suspected tumor. Modern biochemical testing now makes diagnosis of PPGL relatively simple. Integration of artificial intelligence into the process should make it possible to fine-tune these advances.
Recombinant polio–rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial
Authors: Eric M Thompson, Daniel Landi, Michael C Brown, Henry S Friedman, Roger McLendon, James E Herndon, Evan Buckley, Dani P Bolognesi, Eric Lipp, Kristin Schroeder, Oren J Becher, Allan H Friedman, Zachary McKay, Ashley Walter, Stevie Threatt, Denise Jaggers, Annick Desjardins, Matthias Gromeier, Darell D Bigner, David M Ashley
Journal: The Lancet Child & Adolescent Health (2023)
Clinical outcomes of uninterrupted embryo culture with or without time-lapse-based embryo selection versus interrupted standard culture (SelecTIMO): a three-armed, multicentre, double-blind, randomised controlled trial
Authors: D C Kieslinger, C G Vergouw, L Ramos, B Arends, M H J M Curfs, E Slappendel, E H Kostelijk, M H E C Pieters, D Consten, M O Verhoeven, D E Besselink, F Broekmans, B J Cohlen, J M J Smeenk, S Mastenbroek, C H de Koning, Y M van Kasteren, E Moll, J van Disseldorp, E A Brinkhuis, E A M Kuijper, W M van Baal, H G I van Weering, P J Q van der Linden, M H Gerards, P M Bossuyt, M van Wely, C B Lambalk
Journal: The Lancet (2023)
Tecovirimat concentrations and viral suppression in seminal fluid from patients with mpox
Authors: Massimo Tempestilli, Annalisa Mondi, Giulia Matusali, Davide Mariotti, Carmela Pinnetti, Alessia Beccacece, Eleonora Cimini, Valentina Mazzotta, Fabrizio Carletti, Paolo Faccendini, Fabrizio Maggi, Enrico Girardi, Emanuele Nicastri, Francesco Vaia, Andrea Antinori
Journal: The Lancet Infectious Diseases (2023)
Magnifying endoscopy with narrow-band imaging and salvage endoscopic submucosal dissection of a locally advanced rectal adenocarcinoma after neoadjuvant chemoradiotherapy
Authors: Weiguang Li, Xiaoyan Chen, Qukai Liu, Aihua Qian
Journal: Endoscopy (2023)

A 61-year-old man underwent colonoscopy because of bloody stools. Colonoscopy showed an elevated lesion of 25 × 15 mm about 3 cm from the anus ([Fig. 1 a]). Histological examination of the biopsy indicated that this was an adenocarcinoma. Endoscopic ultrasound (EUS) showed that the lesion was involving the muscularis propria. Computed tomography (CT) and rectal magnetic resonance imaging (MRI) resulted in a staging classification of T2N0M0.
Endoscopic submucosal dissection of an atypical rectal submucosal lesion: a rare case of a large digestive angiodyplasia of exclusive submucosal presentation
Authors: Jean Grimaldi, Louis-Jean Masgnaux, Timothée Wallenhorst, Valérie Hervieu, Jérémie Jacques, Jérôme Rivory, Mathieu Pioche
Journal: Endoscopy (2023)

We report here the case of a 37-year-old patient without comorbidities referred to our unit for endoscopic submucosal dissection (ESD) resection of a submucosal lesion of the lower rectum. The lesion measured 40 × 30 mm and did not present any mucosal abnormality ([Fig. 1], [Fig. 2]). An echo-endoscopy was performed prior to resection, showing an atypical anechogenic duct within the lesion ([Fig. 3]) without clear blood flow on Doppler analysis, which initially led to the suspicion of an ectopic gland or a fistulated rectal gland.
Novel resection technique for large flat colorectal tumors: Clip-line-assisted underwater endoscopic mucosal resection
Authors: Emi Kwon Ohmura, Tatsuma Nomura, Hiroto Suzuki, Keiichi Ito
Journal: Endoscopy (2023)

Underwater endoscopic mucosal resection (U-EMR) enables the resection of large colorectal tumors without local injection [1]. Endoscopic submucosal dissection (ESD) is often used for lesions larger than 20 mm. Historically, the rate of en bloc resection with U-EMR is lower than that with ESD [2]. We have devised clip-line-assisted U-EMR (CLU-EMR) for the resection of large tumors in the duodenum [3]. Herein, we present the successful resection of a large, flat 40-mm colorectal tumor using CLU-EMR.
Laser ablation under intraductal cholangioscopic guidance for cholangiocarcinoma
Authors: Mingxing Xia, Xianrong Hu, Ting Zhang, Jinbing Sun, Cui Chen, Bing Hu
Journal: Endoscopy (2023)

An 82-year-old man was admitted for progressively worsening jaundice. Magnetic resonance cholangiopancreatography (MRCP) showed a stenosis of 2 cm in length in the common bile duct, with dilatation of the biliary system above ([Fig. 1]). Endoscopic retrograde cholangiopancreatography (ERCP)-guided cytologic brushing confirmed adenocarcinoma. The patient refused surgery owing to his age and significant co-morbidities. Another ERCP with intraductal cholangioscopic (SpyGlass) observation was arranged. Some mucosal erosions and nodular hyperplasia were found endoscopically ([Fig. 2]). A circumferential irradiation fiber was introduced through the channel of the endoscope ([Fig. 3]) and connected to a laser system (Leonardo, 1470 nm and 980 nm dual wavelength; CeramOpteec GmbH of Biolitec AG, Bonn, Germany). Continuous ablation was carried out until all visualized tumors had been burned to a whitish and necrotic appearance, producing a wider lumen ([Fig. 4]), before a metal stent was placed ([Fig. 5]). The patient recovered unremarkably and was discharged 5 days later ([Video 1]).
A rare pancreatic tumor mimicking chronic calcified pancreatitis
Authors: Mingxing Xia, Bing Hu
Journal: Endoscopy (2023)

A 48-year-old woman was admitted for severe upper abdominal pain, with impressive dilation and multiple high-density stones in the main pancreatic duct (PD). The patient was diagnosed with "chronic pancreatitis" and a therapeutic endoscopic retrograde cholangiopancreatography (ERCP) was planned.
Successful re-intervention using endoscopic ultrasound-guided drainage via an endoscopic tapered sheath for recurrent walled-off necrosis with fibrosis
Authors: Hirotsugu Maruyama, Akira Higashimori, Natsumi Maeda, Yuki Ishikawa-Kakiya, Masafumi Yamamura, Kojiro Tanoue, Yasuhiro Fujiwara
Journal: Endoscopy (2023)

Patients with disconnected pancreatic duct syndrome recur with pancreatic fluid collection in 17–38 % of cases after transmural stent removal [1] [2]. Symptomatic patients require endoscopic re-intervention; however, an approach via the same puncture route is often complicated by fibrosis caused by previous treatment. Long-term placement of a plastic stent is recommended for endoscopic ultrasound-guided drainage of a recurrent walled-off necrosis (WON). However, commonly used pigtail stents are difficult to pass through a fistula even post-dilation, especially in fibrotic cases. Lumen-apposing metal stents can be easily employed in such cases, albeit with an increased risk of serious adverse events in long-term placements [3] [4]. We report a successful re-intervention using endoscopic ultrasound-guided drainage via an endoscopic tapered sheath (EndoSheather; Piolax, Inc., Kanagawa, Japan) ([Fig. 1]) for a recurrent WON with fibrosis.
Endoscopic ultrasound-guided stent-in-stent bridging for a late buried gastroenteric lumen-apposing metal stent
Authors: Beatriz Burgueño-Gomez, Carlos Chavarría, Esteban Fuentes-Valenzuela, Ramón Sánchez-Ocaña, Carlos de la Serna-Higuera, Manuel Perez-Miranda
Journal: Endoscopy (2023)

Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) stent dysfunction is uncommon and most often caused by food impaction [1]. We report the use of EUS-guided stent-in-stent bridging to treat a buried gastroenteric lumen-apposing metal stent (LAMS).
Novel hemostatic option using self-assembling peptide gel for endoscopic necrosectomy-related bleeding
Authors: Takehiko Koga, Yusuke Ishida, Naoaki Tsuchiya, Takanori Kitaguchi, Takashi Kurogi, Yasuharu Shimoji, Fumihito Hirai
Journal: Endoscopy (2023)

Bleeding is the most common complication during direct endoscopic necrosectomy (DEN) for walled-off pancreatic necrosis (WON) [1]. However, there is no consensus on the optimal hemostatic method for DEN-related bleeding. Here, we demonstrate endoscopic hemostasis using PuraStat (3D-Matrix Europe SAS, France), a novel self-assembling peptide hemostatic gel for DEN-related bleeding ([Video 1]).
En bloc resection by polypectomy with over-the-scope clip for a neuroendocrine tumor located in a duodenal bulb pocket
Authors: Mai Watanabe, Kouichi Nonaka, Yoshitsugu Misumi
Journal: Endoscopy (2023)

Neuroendocrine tumors (NETs) are located primarily in the submucosal layer and require careful resection. Conventional endoscopic mucosal resection (EMR) has a risk of positive deep resection margins. En bloc resection is more feasible in endoscopic submucosal dissection (ESD); however, in the duodenum, there is a heightened risk of intraoperative or delayed perforation owing to the thin duodenal wall and effects of inflowing bile and pancreatic juices [1]. The use of an over-the-scope (OTS) clip during polypectomy can greatly reduce the perforation risk [2] and is reportedly safe for duodenal NETs [3]. However, its use during polypectomy to resect NETs located in the pocket of a duodenal ulcer scar has not been reported. We report the use of this method for the safe, rapid, en bloc resection of such tumors located in the anterior wall of the duodenal bulb ([Fig. 1], [Fig. 2], [Video 1]).
Distinct trajectories distinguish antigen-specific T cells in peanut-allergic individuals undergoing oral immunotherapy
Authors: Justine Calise, Hannah DeBerg, Nahir Garabatos, Sugandhika Khosa, Veronique Bajzik, Lorena Botero Calderon, Kelly Aldridge, Mario Rosasco, Brian C. Ferslew, Tong Zhu, Ronald Smulders, Lisa M. Wheatley, Tanya M. Laidlaw, Tielin Qin, Gurunadh R. Chichili, Daniel C. Adelman, Mary Farrington, David Robinson, David Jeong, Stacie M. Jones, Srinath Sanda, David Larson, William W. Kwok, Carolyn Baloh, Gerald T. Nepom, Erik Wambre, Edwin H. Kim, Kari C. Nadeau, Anna Nowak-Wegrzyn, Robert A. Wood, Hugh A. Sampson, Amy M. Scurlock, Sharon Chinthrajah, Julie Wang, Robert D. Pesek, Sayantani B. Sindher, Mike Kulis, Jacqueline Johnson, Katharine Spain, Denise C. Babineau, Hyunsook Chin, Joy Laurienzo-Panza, None Rachel Yan, David Larson, None Tielin Qin, Don Whitehouse, Michelle L. Sever, Srinath Sanda, Marshall Plaut, Lisa M. Wheatley, A. Wesley Burks, Gina Marchesini, Kavitha Gilroy, Sylvia Posso, Sabrina Skiba, Thien-Son Nguyen, Adam Wojno, Tuan Nguyen, Vivian Gersuk, Quynh-Anh Nguyen, Jessica Garber, Kimberly O’Brien, Brandon Larson, C. Cousens-Jacobs, Alex Hu
Journal: Journal of Allergy and Clinical Immunology (2023)
Emergence of meropenem and levofloxacin resistance in Burkholderia pseudomallei in Taiwan
Authors: Pin-Han Wu, Chih-Hao Chen, Wen-Hsin Hsih, Chia-Huei Chou, Chih-Yu Chi, Mao-Wang Ho, Yu-Tzu Lin, Hsiu-Hsien Lin, Kun-Hao Tseng, Po-Ren Hsueh
Journal: Journal of Infection (2023)
Trastuzumab Deruxtecan for Human Epidermal Growth Factor Receptor 2–Expressing Advanced or Recurrent Uterine Carcinosarcoma (NCCH1615): The STATICE Trial
Authors: Tadaaki Nishikawa, Kosei Hasegawa, Koji Matsumoto, Masahiko Mori, Yasuyuki Hirashima, Kazuhiro Takehara, Kazuya Ariyoshi, Tomoyasu Kato, Shigehiro Yagishita, Akinobu Hamada, Mamiko Kawasaki, Satoshi Kawashima, Sawako Tomatsuri, Yukari Nagasaka, Hiroshi Yoshida, Ryunosuke Machida, Akihiro Hirakawa, Kenichi Nakamura, Kan Yonemori
Journal: Journal of Clinical Oncology (2023)

PURPOSE To investigate the efficacy and safety of trastuzumab deruxtecan, an antibody-drug conjugate targeting human epidermal growth factor receptor 2 (HER2) with a topoisomerase I inhibitor payload, in patients with uterine carcinosarcoma (UCS) expressing HER2. PATIENTS AND METHODS Patients with recurrent UCS with HER2 immunohistochemistry scores ≥1+ previously treated with chemotherapy were included. Patients were assigned to the HER2-high (immunohistochemistry score ≥2+; n = 22) or low (immunohistochemistry score of 1+; n = 10) groups for primary and exploratory analyses, respectively. Trastuzumab deruxtecan 6.4 or 5.4 mg/kg was administered intravenously once every 3 weeks until unacceptable toxicity or disease progression. Dose modification was based on the updated recommended phase II dose for breast cancer to be 5.4 mg/kg. The primary end point was the objective response rate by central review in the HER2-high group. Secondary end points included the overall response rate (ORR) in the HER2-high group by investigator assessment, ORR in the HER2-low group, progression-free survival (PFS), overall survival (OS), and safety. RESULTS The ORR by central review in the HER2-high and HER2-low groups were 54.5% (95% CI, 32.2 to 75.6) and 70.0% (95% CI, 34.8 to 93.3) and those by investigator assessments were 68.2% and 60.0%, respectively. The median PFS and OS in the HER2-high and HER2-low groups were 6.2 and 13.3 months and 6.7 months and not reached, respectively. Grade ≥ 3 adverse events occurred in 20 patients (61%). Grades 1-2 and 3 pneumonitis/interstitial lung disease occurred in eight (24%) and one (3%) patient, respectively. CONCLUSION Trastuzumab deruxtecan has efficacy in patients with UCS, regardless of HER2 status. The safety profile was generally consistent with that previously reported. Toxicities were manageable with appropriate monitoring and treatment.
Randomized Double-Blind Placebo-Controlled Study of Olanzapine for Chemotherapy-Related Anorexia in Patients With Locally Advanced or Metastatic Gastric, Hepatopancreaticobiliary, and Lung Cancer
Authors: Lakshmi Sandhya, Nirmala Devi Sreenivasan, Luxitaa Goenka, Biswajit Dubashi, Smita Kayal, Manikandan Solaiappan, Ramkumar Govindarajalou, Harichandrakumar KT, Prasanth Ganesan
Journal: Journal of Clinical Oncology (2023)

PURPOSE Anorexia occurs in 30%-80% of patients with advanced malignancies, which may be worsened with chemotherapy. This trial assessed the efficacy of olanzapine in stimulating appetite and improving weight gain in patients receiving chemotherapy. METHODS Adults (≥18 years) with untreated, locally advanced, or metastatic gastric, hepatopancreaticobiliary (HPB), and lung cancers were randomly assigned (double-blind) to receive olanzapine (2.5 mg once a day for 12 weeks) or placebo along with chemotherapy. Both groups received standard nutritional assessment and dietary advice. The primary outcomes were the proportion of patients with weight gain &gt; 5% and the improvement in appetite (assessed by the visual analog scale [VAS] and the Functional Assessment of Chronic Illness Therapy system of Quality-of-Life questionnaires Anorexia Cachexia subscale [FAACT ACS]). Secondary end points were change in nutritional status, quality of life (QOL), and chemotherapy toxicity. RESULTS We enrolled 124 patients (olanzapine, 63 and placebo, 61) with a median age of 55 years (18-78 years), of whom 112 (olanzapine, 58 and placebo, 54) were analyzable. The majority (n = 99, 80%) had metastatic cancer (gastric [n = 68, 55%] &gt; lung [n = 43, 35%] &gt; HPB [n = 13, 10%]). The olanzapine arm had a greater proportion of patients with a weight gain of &gt; 5% (35 of 58 [60%] v 5 of 54 [9%], P &lt; .001) and improvement in appetite by VAS (25 of 58 [43%] v 7 of 54 [13%], P &lt; .001) and by FAACT ACS (scores ≥37:13 of 58 [22%] v 2 of 54 [4%], P = .004). Patients on olanzapine had better QOL, nutritional status, and lesser chemotoxicity. Side effects attributable to olanzapine were minimal. CONCLUSION Low-dose, daily olanzapine is a simple, inexpensive, well-tolerated intervention that significantly improves appetite and weight gain in newly diagnosed patients on chemotherapy.
Impact on alcohol selection and online purchasing of changing the proportion of available non-alcoholic versus alcoholic drinks: A randomised controlled trial
Authors: Natasha Clarke, Anna K. M. Blackwell, Jennifer Ferrar, Katie De-Loyde, Mark A. Pilling, Marcus R. Munafò, Theresa M. Marteau, Gareth J. Hollands
Journal: PLoS Medicine (2023)

Increasing the availability of non-alcoholic options is a promising population-level intervention to reduce alcohol consumption, currently unassessed in naturalistic settings. This study in an online retail context aimed to estimate the impact of increasing the proportion of non-alcoholic (relative to alcoholic) drinks, on selection and purchasing of alcohol.
Astrocytes: integrators of arousal state and sensory context
Authors: Rune Nguyen Rasmussen, Antonis Asiminas, Eva Maria Meier Carlsen, Celia Kjaerby, Nathan Anthony Smith
Journal: Trends in Neurosciences (2023)

The integration of external information with the internal state of the body is central to the survival of virtually every multicellular organism. However, a complete picture of the mechanisms that govern this process is lacking. In this opinion article, we synthesize evidence demonstrating that astrocytes sense the momentary arousal state - through neuromodulator release - as well as the sensory inputs - through local synaptic activity - and respond to them with changes in calcium (Ca
Structured Mobilization for Critically Ill Patients: A Pragmatic Cluster-randomized Trial
Authors: William D. Schweickert, Julianne Jablonski, Brian Bayes, Marzana Chowdhury, Casey Whitman, Jenny Tian, Bryan Blette, Teresa Tran, Scott D. Halpern
Journal: American Journal of Respiratory and Critical Care Medicine (2023)

Rationale: Small trials and professional recommendations support mobilization interventions to improve recovery among critically ill patients, but their real-world effectiveness is unknown. Objective: To evaluate a low-cost, multifaceted mobilization intervention. Methods: We conducted a stepped-wedge cluster-randomized trial across 12 ICUs with diverse case mixes. The primary and secondary samples included patients mechanically ventilated for ⩾48 hours who were ambulatory before admission, and all patients with ICU stays ⩾48 hours, respectively. The mobilization intervention included 1) designation and posting of daily mobilization goals; 2) interprofessional closed-loop communication coordinated by each ICU's facilitator; and 3) performance feedback. Measurements and Main Results: From March 4, 2019 through March 15, 2020, 848 and 1,069 patients were enrolled in the usual care and intervention phases in the primary sample, respectively. The intervention did not increase the primary outcome, patient's maximal Intensive Care Mobility Scale (range, 0-10) score within 48 hours before ICU discharge (estimated mean difference, 0.16; 95% confidence interval, -0.31 to 0.63; P = 0.51). More patients in the intervention (37.2%) than usual care (30.7%) groups achieved the prespecified secondary outcome of ability to stand before ICU discharge (odds ratio, 1.48; 95% confidence interval, 1.02 to 2.15; P = 0.04). Similar results were observed among the 7,115 patients in the secondary sample. The percentage of days on which patients received physical therapy mediated 90.1% of the intervention effect on standing. ICU mortality (31.5% vs. 29.0%), falls (0.7% vs. 0.4%), and unplanned extubations (2.0% vs. 1.8%) were similar between groups (all P > 0.3). Conclusions: A low-cost, multifaceted mobilization intervention did not improve overall mobility but improved patients' odds of standing and was safe. Clinical trial registered with www.clinicaltrials.gov (NCT03863470).
Correction: Development and validation of a model for predicting incident type 2 diabetes using quantitative clinical data and a Bayesian logistic model: A nationwide cohort and modeling study
Authors: Lua Wilkinson, Nengjun Yi, Tapan Mehta, Suzanne Judd, W. Timothy Garvey
Journal: PLoS Medicine (2023)

[This corrects the article DOI: 10.1371/journal.pmed.1003232.].
Measurable Residual Disease and Fusion Partner Independently Predict Survival and Relapse Risk in Childhood <i>KMT2A</i>-Rearranged Acute Myeloid Leukemia: A Study by the International Berlin-Frankfurt-Münster Study Group
Authors: Romy E. van Weelderen, Kim Klein, Christine J. Harrison, Yilin Jiang, Jonas Abrahamsson, Nira Arad-Cohen, Emmanuelle Bart-Delabesse, Barbara Buldini, Barbara De Moerloose, Michael N. Dworzak, Sarah Elitzur, José M. Fernández Navarro, Robert B. Gerbing, Bianca F. Goemans, Hester A. de Groot-Kruseman, Erin Guest, Shau-Yin Ha, Henrik Hasle, Charikleia Kelaidi, Hélène Lapillonne, Guy Leverger, Franco Locatelli, Riccardo Masetti, Takako Miyamura, Ulrika Norén-Nyström, Sophia Polychronopoulou, Mareike Rasche, Jeffrey E. Rubnitz, Jan Stary, Anne Tierens, Daisuke Tomizawa, C. Michel Zwaan, Gertjan J.L. Kaspers
Journal: Journal of Clinical Oncology (2023)

A previous study by the International Berlin-Frankfurt-Münster Study Group (I-BFM-SG) on childhood