tbuckley/cabot-search huggingface dataset:
ARE MITOCHONDRIA IDENTICAL WITH BACTERIA?
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endoscopic ultrasonography
Authors: M. Polkowski
Journal: Endoscopy (2012)

Wiersema et al. first reported results of endoscopic ultrasonograpy-guided celiac plexus neurolysis (EUS-CPN) in 1996 [2]. Since then, this method has been evaluated in only a few observational uncontrolled studies and a handful of randomized controlled trials (RCTs) that focused on technical variations of the procedure but did not include a “no active intervention” arm [3] [4]. Consequently, although the results indicated that EUS-CPN reduces pain and opioid use in patients with pancreatic cancer, definite conclusions about the true effectiveness of this method have been precluded by the absence of comparative studies with conventional (systemic) analgesic therapy [3] [4].
"HOW MUCH IS TOO MUCH? THE TREATMENT OF MILD ASTHMA". P.M. O'BYRNE. EUR RESPIR J 2007; 30: 403 406.
Journal: European Respiratory Journal (2007)

Unfortunately, a section of the text in above paper was reported incorrectly.The sixth sentence in the second paragraph of the section entitled ''Is it worth using regular ICS in mild persistent asthma?''should have read as follows: ''The recent study by PAPI et al.[10] provides an interesting alternative to regular daily ICS, whereby patients use a combination inhaler of ICS and a shortacting b 2 -agonist, as needed.''The author apologises for this error.
Consumer competence and the reform of American health care
Authors: S. J. Reiser
Journal: JAMA (1992)

This report examines the role of the expert in the American health care system, both as provider and administrative policymaker. It shows that the guiding assumption of American health care policy, ie, that the medical system can and should be managed by experts on behalf of consumers and patients, does not hold up to scrutiny. It also demonstrates that the important theme in American history of placing authority and responsibility for action in the hands of the individual has not been sufficiently influential in American health care. Drawing on this theme and creating consumer competence and responsibility in health care choices as the keys to health care reform in the United States are advocated. (<i>JAMA</i>. 1992;267:1511-1515)
Differential activation of transcription factors NF-?B and AP-1 in rat liver macrophages*1, *2, *3
Authors: T TRANTHI
Journal: Hepatology (1995)

Liver macrophages (Kupffer cells) respond to many stimulations with the production of bioactive substances including cytokines, eicosanoids, and inorganic radicals. In this study the activation of transcription factors by substances inducing cytokine gene expression or superoxide formation in rat Kupffer cells was examined. Using primary cultures of rat Kupffer cells the role of NF-κB and activator protein 1 (AP-1) in the expression of the tumor necrosis factor-alpha (TNF-α) gene by lipopolysaccharide (LPS) was investigated. Both transcription factors were strongly activated but with different kinetics. Maximal DNA-binding activity was induced with 50 ng of LPS/mL of medium and persisted for at least 24 hours. At that time, NF-κB- as well as AP-1-DNA complexes decreased their mobilities in native gels. Among the cytokines tested only TNF-α and macrophage colony-stimulating factor (M-CSF) were able to activate NF-κB in Kupffer cells. Phorbol ester and zymosan activated AP-1 but not NF-κB; the treatment of zymosan yielding a modified form of AP-1. Of all substances found to interfere with TNF-α production by Kupffer cells (pyrrolidine dithiocarbamate, dexamethasone, prostaglandin E2, interleukin [IL]-4, IL-10, and transforming growth factor-beta [TGF-β]) only pyrrolidine dithiocarbamate was able to completely inhibit the activation of NF-κB by LPS. Although not abrogating the LPS activation of NF-κB, dexamethasone inhibited that of AP-1. The results indicate a direct participation of NF-κB in the regulation of TNF-α synthesis and a differential effect of LPS on NF-κB and AP-1, respectively.
Applied Physiology.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THU0303 Biological Stress Systems, Adverse Life Events and the Onset of Chronic Multi-Site Musculoskeletal Pain: A Six-Year Cohort Study: Table 1.
Authors: E. Generaal, N. Vogelzangs, G.J. Macfarlane, R. Geenen, E. de Geus, J.H. Smit, B.W. Penninx, J. Dekker
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Dysregulated biological stress systems and adverse life events, both independently and in interaction, have been hypothesized to initiate chronic pain. <h3>Objectives</h3> We examine whether (i) function of biological stress systems, (ii) adverse life events, and (iii) their combination predict the onset of chronic multi-site musculoskeletal pain. <h3>Methods</h3> Subjects (n=2039) of the Netherlands Study of Depression and Anxiety, free from chronic multi-site musculoskeletal pain at baseline, were identified using the Chronic Pain Grade Questionnaire and followed-up for the onset of chronic multi-site musculoskeletal pain over 6 years. Baseline assessment of biological stress systems comprised function of the hypothalamic-pituitary-adrenal (HPA)-axis (1-h cortisol awakening response, evening levels, post-dexamethasone levels), the immune system (IMS; basal and lipopolysaccharide-stimulated inflammation) and the autonomic nervous system (ANS; heart rate, pre-ejection period, standard deviation of the normal-to-normal interval, respiratory sinus arrhythmia). The number of recent adverse life events were assessed at baseline using the List of Threatening Events Questionnaire. <h3>Results</h3> HPA-axis, IMS and ANS functioning was not associated with onset of chronic multi-site musculoskeletal pain, either by itself or in interaction with adverse life events. Adverse life events did predict onset of chronic multi-site musculoskeletal pain. <h3>Conclusions</h3> This longitudinal study<sup>1</sup> could not confirm that dysregulated biological stress systems increase the risk of developing chronic multi-site musculoskeletal pain. Adverse life events were a risk factor for the onset of chronic multi-site musculoskeletal pain, suggesting that psychosocial factors play a role in triggering the development of this condition. <h3>References</h3> Generaal E, Vogelzangs N, MacFarlane GJ, Geenen R, Smit JH, de Geus EJ, Penninx BW, and Dekker J. Biological stress systems, adverse life events and the onset of chronic multi-site musculoskeletal pain: a six-year cohort study. Submitted for publication to Annals of the Rheumatic Diseases, 2014. <h3>Disclosure of Interest</h3> None declared
NUTRITIONAL XEROPHTHALMIA
Authors: J. A. THORSON
Journal: JAMA (1934)

Early Egyptian literature and the teachings of Hippocrates are quoted as prescribing a liver diet for hemeralopia, one of the symptoms of avitaminosis. By recent experiment,<sup>1</sup>this therapy has been proved scientifically correct. In 1857 Livingstone,<sup>2</sup>describing a disorder of the eyes in members of his African party, wrote that the eyes became affected, as in the case of experimental animals fed on pure gluten or starch; yet it was not until fifty-five years later that Hopkins<sup>3</sup>first gave definite proof of the existence of fat-soluble vitamin A. In the following year, 1913, Osborne and Mendel<sup>4</sup>experimentally produced characteristic xerophthalmia and proved that it could be cured, in rats, by the addition of butter fat or cod liver oil to the deficient diet. From this time until 1922, when McCollum and his associates<sup>5</sup>differentiated vitamins A and D, many of the abnormalities reported following clinical
THE ETIOLOGIC RELATION EXISTING BETWEEN CERTAIN NEUROSES AND DIET, AND ITS THERAPEUTIC APPLICATIONS.
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Occupational cancer in Germany
Authors: I Brüske-Hohlfeld
Journal: Environmental Health Perspectives (1999)

As in probably mostly all other European countries, the incidence of occupational cancer in Germany increased steadily after World War II.In 1994 about 1,600 cases of occupational cancer were compensated-more than ever before.More than half of these cases were lung cancer, most caused either by asbestos (n= 545) or by ionizing radiation (n = 306).Other frequent target organs of asbestos were the pleura and the peritoneum with 495 cases of mesotheliomas.Asbestos was the single most important risk factor for occupational cancer, causing more than 1000 deaths per year.All other malignant diseases, such as bladder cancer, leukemia, angiosarcoma of the liver, adenocarcinoma of the nose or nasal sinuses, and skin cancer, were comparatively rare.Although primary exposure to ionizing radiation in uranium ore mining occurred in the 1 950s and attributable lung cancers seem to be on the decline, this is not true for asbestos, where the peak incidence in lung cancer and mesothelioma has not been reached yet.
Stimulatory effect of Pseudomonas aeruginosa on mucin secretion by the respiratory epithelium
Authors: K. B. Adler
Journal: JAMA (1983)

Cell-free filtrates of broth cultures from 11 of 18 strains of<i>Pseudomonas aeruginosa</i>isolated from patients with cystic fibrosis (CF) (or from patients without CF) increased substantially the secretion of mucin by explants of trachea from guinea pigs and human tracheal tissue obtained at autopsy. The effect was not related to the mucoid nature of the isolates, was not destroyed by heating at 90 °C for 30 minutes, and was not dependent on serotype. As<i>P aeruginosa</i>commonly infects the respiratory tracts of persons with CF, elaboration of an extracellular product that stimulates mucin secretion could play a role in the pathogenesis of the disease in the airways. (<i>JAMA</i>1983;249:1615-1617)
Dosage Confused
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diethylstilbestrol therapy gynecomastia
Authors: D. A. Hendrickson
Journal: JAMA (1970)

<h3>To the Editor:—</h3> Gynecomastia may complicate prolonged hormonal therapy for adenocarcinoma of the prostate. Formation of acinar tissue with secretory activity may also arise in the breast of a man, but examples have only rarely been cited. This unusual complication occurred in a patient developing marked breast enlargement concurrent with prolonged diethylstilbestrol (stilbestrol) therapy. <h3>Report of a Case.—</h3> A 62-year-old Negro was hospitalized at Hennepin County General Hospital in February 1969 for lumbosacral back pain attributed to metastatic prostatic carcinoma. Transurethral prostatectomy 13 years previously had revealed adenocarcinoma of the prostate. Following bilateral orchiectomy the patient received 5 mg of diethylstilbestrol daily continuously until December 1968 when bone survey confirmed osteoblastic lesions secondary to metastatic carcinoma throughout the vertebral column, clavicles, calvarium, and long bones of the extremities. Diethylstilbestrol administration was then increased to 15 mg three times daily for ten days and then tapered to 5 mg three times
Leg Swelling after Gene Therapy for Peripheral Vascular Disease
Journal: Annals of Internal Medicine (2000)

Summaries for Patients6 June 2000Leg Swelling after Gene Therapy for Peripheral Vascular DiseaseSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-11-200006060-00035 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Peripheral vascular disease refers to a narrowing of the blood vessels in the extremities, typically the legs and feet, which leads to lack of adequate blood supply. Patients with moderate peripheral vascular disease develop leg and foot pain during activity, a condition called claudication. When the disease is more severe, patients experience pain even without exercise, a condition known as pain at rest. When the disease is most severe, tissues that do not get enough blood can die, and the patient develops sores on the leg or foot ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Lower-Extremity Edema Associated with Gene Transfer of Naked DNA Encoding Vascular Endothelial Growth Factor.” It is in the 6 June 2000 issue of Annals of Internal Medicine (volume 132, pages 880-884). The authors are I. Baumgartner, G. Rauh, A. Pieczek, D. Wuensch, M. Magner, M. Kearney, R. Schainfeld, and J.M. Isner.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. Previousarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLower-Extremity Edema Associated with Gene Transfer of Naked DNA Encoding Vascular Endothelial Growth Factor Iris Baumgartner , Guenter Rauh , Ann Pieczek , Debra Wuensch , Meredith Magner , Marianne Kearney , Robert Schainfeld , and Jeffrey M. Isner Metrics 6 June 2000Volume 132, Issue 11Page: 880KeywordsBlood vesselsDiureticsGene therapyGene transferInflammationMusclesPeripheral vascular diseaseUlcersVascular endothelial growth factorVascular medicine ePublished: 15 August 2000 Issue Published: 6 June 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...
Correction
Journal: BMJ (1955)

ANY QUESTIONS ? BIUTISH(2) Inhabitants of cold climates do exhibit slower pulse rates -than those of hot climates,2 but the differences are only evident under basal conditions: Relationship Between Basal Pulse Rate and Mean Annual Temperature Cold Climates.-N.American Indians, 53 per minute; Mukden (Manchuria), 53 per minute; Miao (China, high altitude), 55 per minute; Peking, 61 per minute.Hot Climates.-Javanese, 67per minute; Hong Kong, 64 per minute; Bengal, 67 per minute; Australia (aborigines), 65 per minute.An athlete is not a good long-distance runner simply because he has an exceptionally slow heart action.More often the converse is true, the slow heart rate being the result of prolonged athletic training.Athletic bradycardia is not confined to runners, but is frequently found in persons subjected to almost any form of strenuous physical conditioning, and is particularly marked in marathon runners and weight-lifters.3Quantitative differences in training, and age differences, also play a part in the retardation of pulse frequency.Long-distance and marathon runners are usually older men with greater athletic experience than sprinters and middle-distance runners.'It is unlikely that the success of Scandinavians in long- distance contests can be explained by " racial" bradycardia, and it is doubtful whether the heart action of Scandinavian runners is any slower than that of well-trained runners of any race.A more likely explanation is that a bigger pro- portion of Scandinavians train specifically for the long- distance events, and have consequently evolved training techniques superior to those of their rivals in countries where long-distance running is less popular.The import- ance to athletic achievement of improved training tech- niques and psychological factors has recently been stressed in this Journal.5 6 and must not be overlooked when trying to assess the value of natural anatomical and physiological advantages.
A CASE OF EPIDEMIC ENCEPHALITIS WITH UNUSUAL FEATURES
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Authors’ reply: Systematic literature analysis and review of targeted preventive measures to limit healthcare-associated infections by meticillin-resistant Staphylococcus aureus
Authors: R Köck, A W Friedrich, collective on behalf of the original author group
Journal: Eurosurveillance (2014)

Preview this article: Authors' reply: Systematic literature analysis and review of targeted preventive measures to limit healthcare-associated infections by meticillin-resistant Staphylococcus aureus, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/19/37/art20902-en-1.gif
Coronary artery spasm.
Journal: BMJ (1979)

Coronary artery spasmAs one controversy is settled in coronary artery disease, another replaces it, for deeper study is apt to show how complex are even apparently simple problems.The mechanism of atheroma is still in debate, and there is no agreement whether in fatal myocardial infarction the thrombus found in the artery precedes and causes the acute ischaemia or is a consequence of it.1 2
FD&amp;C Yellow No. 6:Condensation of the Carcinogenesis Bioassay Technical Report*
Journal: Environmental Health Perspectives (1982)

desserts, sherbets, carbon- ated beverages, candies, cereals, jams, pickles, smoked fish, puddings, medicinals (liquids, tablets, and capsules), toothpastes, hair rinses, and other foods, drugs, and cosmetics.
Gastroscopic Cytology
Authors: S. Witte
Journal: Endoscopy (1970)

The gastroscopic selective collection of cytologic material can be practiced with abrasive and washing methods. Techniques have been developed so that the whole gastric wall can be selectively reached by cytodiagnostic methods. Cytological material of the highest quality can be collected in sufficient quantity. Technical and methodological details must be considered. According to present limited experiences, diagnostic efficiency seems to be very good. A comparison with gastroscopic directed biopsy shows that both methods of microscopic diagnostics complement each other and enhance the likelihood of recognizing a carcinoma of the stomach.