tbuckley/cabot-search huggingface dataset:
Impact of endobiliary radiofrequency ablation on survival of patients with advanced extrahepatic cholangiocarcinoma under systemic chemotherapy
Authors: Christian Möhring, Maria Angeles Gonzalez-Carmona, Robert Mahn, Taotao Zhou, Alexandra Bartels, Farsaneh Sadeghlar, Maximilian Bolch, Annabelle Vogt, Dominik Kaczmarek, Dominik Heling, Leona Dold, Jacob Nattermann, Vittorio Branchi, Hanno Matthaei, Steffen Manekeller, Jörg Kalff, Christian Strassburg, Raphael Mohr, Tobias Weismüller
Journal: Journal of Hepatology (2022)
Mixed HCC-CCA originates from hepatic progenitor cells, is dependent on IL6 singling and is ablated by senolytic agents
Authors: Nofar Rosenberg, Matthias Van Haele, Maria Garcia Beccaria, Mirian Fernández-Vaquero, Danijela Heide, Neta Barashi, Amnon Peled, Yuval Nevo, Shrona Elgavish, Dirk Schmist-Arras, Hanan Edler, Alina Simerzin, Michal Shoshkes-Carmel, Klaus Kaestner, Hilla Giladi, Stefan Rose-John, Tania Roskams, Mathias Heikenwälder, Eithan Galun
Journal: Journal of Hepatology (2022)
Predictive immune biomarkers to safely discontinue nucleos (t)ide analogue treatment in HBeAg negative chronic hepatitis B (NUC-B study)
Authors: Sandra Phillips, Sameer Mistry, Nicola Harris, Celia Moore, Gareth Hahn, Michelle Rosario, Camilla Carr-Smith, Maria Cortes Carrillo, Lavanya Elangovan, Kosh Agarwal, James Hand, Chris Sivell, Patrick Kennedy, Susan Congreave, Mathew Barnes, Stephen Ryder, Mariam Habib, Mark Thursz, Shilpa Chokshi
Journal: Journal of Hepatology (2022)
Early Nivolumab addition to Regorafenib in patients with hepatocellular carcinoma progressing under 1st line therapy (GOING trial). Interim analysis and safety profile
Authors: Marco Sanduzzi Zamparelli, Ana M Matilla, Jose Luis Lledó, Sergio Muñoz Martinez, Maria Varela, Mercedes Iñarrairaegui, Christie Perelló, Beatriz Minguez, Neus Llarch, Laura Marquez Perez, Antonio Guerrero, Gemma Iserte, Andrés Castano-Garcia, Laura Carrión, Jordi Rimola, Maria Ángeles García-Criado, Gema Domenech, Loreto Boix, Jordi Bruix, María Reig
Journal: Journal of Hepatology (2022)
Measurement of protease activity using novel plasma biosensors can accurately detect hepatocellular carcinoma
Authors: Tram Tran, Ben Holmes, Chris Gulka, Anatoly Myaskovsky, Andrea Shepard, Mackenzie Rowe, Sophie Cazanave, Fayçal Touti, Alejandro Balbin, Wendy Winckler
Journal: Journal of Hepatology (2022)
Reprogramming necroptosis limits immune responses and prevents liver cancer development
Authors: Mihael Vucur, Ahmed Ghallab, Anne Schneider, Jakob Kather, Olivier Govaere, Augusto Villanueva, Achim Weber, Thomas Longerich, Frank Tacke, Christoph Roderburg, Johannes Bode, Fabian Geisler, Ulf Neumann, Jan G. Hengstler, Mathias Heikenwälder, Tom Lüdde
Journal: Journal of Hepatology (2022)
Safety and effectiveness of vaccines agains SARS-COV-2 in patients with liver cancer. VacHep registry: response analysis 4 weeks after the second dose.
Authors: Elena Diago Sempere, Ana Matilla, Carlos Rodríguez, Christie Perelló, Beatriz Minguez, Maria Varela, Juan José Urquijo, Javier Ampuero, Janire Prieto, Laura Márquez Pérez, Javier Crespo, María Bermúdez, Ana Maria Piedra Cerezal, Moises Diago, Belén Ruiz Antoran, José Luis Calleja Panero
Journal: Journal of Hepatology (2022)
Effectiveness of COVID-19 viral vector vaccine Ad.26.COV2.S vaccine and comparison with mRNA vaccines in patients with cirrhosis
Authors: Binu John, Akash Doshi, Yangyang Deng, Natalie Mansour, A.Sidne Barritt, Andrew Moon, George Ioannou, Paul Martin, Hann-Hsiang Chao, Tamar H Taddei, David Kaplan, Bassam Dahman
Journal: Journal of Hepatology (2022)
Post-treatment elevated gamma-glutamyl transferase is the best predictor for future outcomes in HCV patients achieving sustained virological response-data from the german hepatitis C-registry (DHC-R)
Authors: Stefan Mauss, Hartwig Klinker, Klaus Boeker, Uta Merle, Ralph Link, Peter Buggisch, Dietrich Hüppe, Markus Cornberg, Christoph Sarrazin, Heiner Wedemeyer, Thomas Berg, Frank Tacke, German Hepatitis C-Registry
Journal: Journal of Hepatology (2022)
Peroxisome proliferator activated receptor gamma regulates patatin-like phospholipase domain-containing protein 3 in adipocytes in vitro and in vivo in a mouse model of non-alcoholic steatohepatitis
Authors: Emmanuel Dauda Dixon, Thierry Claudel, Alexander D Nardo, Veronika Mlitz, Claudia Fuchs, Michael Trauner
Journal: Journal of Hepatology (2022)
No detectable resistance to bulevirtide in participants with chronic hepatitis D (CHD) through 24 weeks of treatment
Authors: Julius Hollnberger, Yang Liu, Ross Martin, Savrina Manhas, Thomas Aeschbacher, Silvia Chang, Simin Xu, Bin Han, Tahmineh Yazdi, Lindsey May, Dong Han, Katrin Schöneweis, John F. Flaherty, Vithika Suri, Dmitry Manuilov, Roberto Mateo, Evguenia S Svarovskaia, Hongmei Mo, Stephan Urban
Journal: Journal of Hepatology (2022)
Ductular bilirubinostasis is a diagnostic biomarker for acute-on-chronic liver failure: results from a well-defined cohort of patients with alcoholic steatohepatitis
Authors: Annelotte Broekhoven, Tessa Ostyn, Lukas Van Melkebeke, H.W. Verspaget, Schalk van der Merwe, Jef Verbeek, Minneke Coenraad, Tania Roskams, Frederik Nevens
Journal: Journal of Hepatology (2022)
The number of public health policies reduces the burden and mortality of alcohol-associated liver disease worldwide: a call for action
Authors: Luis Antonio Diaz, Eduardo Fuentes, Francisco Idalsoaga, Jorge Arnold, Gustavo Ayares, Macarena Cannistra, Danae Vio, Andrea Márquez, Oscar Corsi, Alejandro Villalón, Carolina Ramirez, María Paz Medel, Catterina Ferreccio, Mariana Lazo, Juan Pablo Roblero, Anand Kulkarni, Won Kim, Mayur Brahmania, Alexandre Louvet, Elliot Tapper, Winston Dunn, Douglas Simonetto, Vijay Shah, Patrick S. Kamath, Ashwani Singal, Ramon Bataller, Marco Arrese, Juan Pablo Arab
Journal: Journal of Hepatology (2022)
New scoring system using MRI with AST for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis
Authors: Kento Imajo, Yusuke Saigusa, Takashi Kobayashi, Koki Nagai, Shinya Nishida, Nobuyoshi Kawamura, Michihiro Iwaki, Yasushi Honda, Takaomi Kessoku, Yuji Ogawa, Hiroyuki Kirikoshi, Satoshi Yasuda, Hidenori Toyoda, Hideki Hayashi, Hiroyoshi Doi, Shigehiro Kokubu, Daisuke Utsunomiya, Hirokazu Takahashi, Shinichi Aishima, Satoru Saito, Masato Yoneda, Atsushi Nakajima
Journal: Journal of Hepatology (2022)
N-terminal propeptide of type III collagen (PRO-C3) based risk for liver fibrosis predict cardiovascular events in non-alcoholic fatty liver disease
Authors: Francesco Baratta, Giulia Tozzi, Daniele Pastori, Alessandra Colantoni, Nicholas Cocomello, Stefano Cecchi, Mattia Coronati, Francesco Angelico, Maria Del Ben
Journal: Journal of Hepatology (2022)
Effect of liver stiffness on hepatocellular carcinoma phenotype in a biometric 3D model
Authors: Carlemi Calitz, Jaafar Khaled, Jenny Rosenquist, Maria Kopsida, Oliver Degerstedt, Hans Lennernas, Mårten Fryknäs, Ayan Samanta, Femke Heindryckx
Journal: Journal of Hepatology (2022)
Transarterial radioembolisation in non resectable hepatocellular carcinoma in curative strategies: a single centre experience
Authors: Helene Regnault, Clara Perrin, Giuliana Amaddeo, Sebastien Mulé, Hicham Kobeiter, Edouard Reizine, Emmanuel Itti, Christophe Duvoux, Alexis Laurent, Vincent Leroy, Raffaele Brustia, Daniele Sommacale, Françoise Roudot-Thoraval, Lerman Lionel, Alain Luciani, Julien Calderaro, Julia Chalaye, Vania Tacher, Athena Galletto
Journal: Journal of Hepatology (2022)
Diagnostic performance of AGILE 3+ score for identification of advanced fibrosis and prediction of liver-related events in patients with non-alcoholic fatty liver disease
Authors: Grazia Pennisi, Ciro Celsa, Marco Enea, Alessandra Pandolfo, Michela Antonucci, Carlo Ciccioli, Giuseppe Infantino, Claudia La Mantia, Stefanie Parisi, Adele Tulone, Vito Di Marco, Antonio Craxi, Calogero Camma, Salvatore Petta
Journal: Journal of Hepatology (2022)
Extracorporeal membrane oxygenation, a valuable life-saving treatment in liver transplanted patients
Authors: Benjamin Buchard, Sophie-Caroline Sacleux, Samir Jaber, François Stéphan, Alain Combes, Elise Lemaître, Marc Boudon, Audrey Coilly, Faouzi Saliba, Didier Samuel, Armand Abergel, Philippe Ichai
Journal: Journal of Hepatology (2022)
Mathematical modeling of HDV RNA kinetics suggests high peginterferon Lambda efficacy in blocking viral production: insights from the LIMT-1 study
Authors: E Fabian Cardozo-Ojeda, Sarah Duehren, Saeed Sadiq Hamid, Yoav Lurie, Edward J Gane, Anat Nevo-Shor, David Yardeni, Scott Cotler, Ingrid Choong, Jeffrey Glenn, Harel Dahari, Ohad Etzion
Journal: Journal of Hepatology (2022)
Liver-related mortality among people with hepatitis B and C: a validation study using linked healthcare administrative datasets
Authors: Syed Hassan Bin Usman Shah, Maryam Alavi, Behzad Hajarizadeh, Gail Matthews, Marianne Martinello, Mark Danta, Janaki Amin, Matthew Law, Jacob George, Hamish Innes, Gregory Dore
Journal: Journal of Hepatology (2022)
MRCP+TM-derived biliary metrics are associated with disease severity and clinical outcomes in patients with primary sclerosing cholangitis
Authors: Nora Cazzagon, Sanaa El Mouhadi, Quentin Vanderbecq, Carlos Ferreira, Sara Lemoinne, Christophe Corpechot, Olivier Chazouillères, Lionel Arrivè
Journal: Journal of Hepatology (2022)
Ptpn1 deletion protects oval vells against lipoapotosis by favoring lipid droplet formation and dynamics
Authors: Pilar Valdecantos, Ines Barahona, Silvia Calero, Ruben Grillo-Risco, Laura Pereira, Carmen Soler, Lara LaIglesia, M. Jesús Moreno-Aliaga, Laura Herrero, Dolors Serra, Carmelo Garcia-Monzon, Águeda González, Jesus Balsinde, Francisco García-García, Angela Martinez Valverde
Journal: Journal of Hepatology (2022)
Thrombospondin 1: an emerging key-role in the acute-on-chronic liver failure pathogenesis
Authors: Hozeifa Mohamed Hassan, Xi Liang, Jiaojiao Xin, Dongyan Shi, Keke Ren, Qi Chen, Jiang Li, Peng Li, Hui Yang, Jinjin Luo, Jing Jiang, Jun Li
Journal: Journal of Hepatology (2022)
Clinical features of exacerbation of portal vein thrombosis after discontinuation of anticoagulants
Authors: Takayuki Kondo, Kisako Fujiwara, Sae Yumita, Takamasa Ishino, Keita Ogawa, Miyuki Nakagawa, Hidemi Unozawa, Terunao Iwanaga, Takafumi Sakuma, Naoto Fujita, Keisuke Koroki, Hiroaki Kanzaki, Kazufumi Kobayashi, Soichiro Kiyono, Masato Nakamura, Naoya Kanogawa, Tomoko Saito, Sadahisa Ogasawara, Shingo Nakamoto, Tetsuhiro Chiba, Jun Kato, Naoya Kato
Journal: Journal of Hepatology (2022)
A high-throughput viral integration sequencing method reveals that mitochondrial DNA is frequently targeted by HBV integration
Authors: Domenico Giosa, Daniele Lombardo, Cristina Musolino, Valeria Chines, Giuseppina Raffa, Deborah D’aliberti, Francesca Casuscelli di Tocco, Carlo Saitta, Riccardo Aiese Cigliano, Orazio Romeo, Angela Alibrandi, Giuseppe Navarra, Giovanni Raimondo, Teresa Pollicino
Journal: Journal of Hepatology (2022)
Potential role of soluble triggering receptor expressed on myeloid cells 2 in risk stratification of patients with hepatocellular carcinoma
Authors: Francesca Baorda, Federico Ceruti, Antonio Acquaviva, Giulia Francesca Manfredi, Davide Di Benedetto, Michela Emma Burlone, Rosalba Minisini, Mattia Bellan, Cristina Rigamonti, Mario Pirisi
Journal: Journal of Hepatology (2022)
A third dose of the BNT162b2 mRNA vaccine significantly improved immune response among liver transplant recipients
Authors: Yana Davidov, Victoria Indenbaum, Keren Tsaraf, Oranit Cohen-ezra, Mariya Likhter, Gil Ben Yaacov, Rebecca Halperin, Itzchak Levy, Orna Mor, Nancy Agmon-Levin, Arnon Afek, Galia Rahav, Yaniv Lustig, Ziv Ben Ari
Journal: Journal of Hepatology (2022)
Innovative linkage model to re-engage loss-to-follow-up individuals in the national hepatitis C elimination program of Georgia
Authors: Amiran Gamkrelidze, Alexander Turdziladze, Maia Tsreteli, Vladimer Getia, Ana Aslanikashvili, Sophia Surguladze, Irina Tskhomelidze, Shaun Shadaker, Paige A Armstrong
Journal: Journal of Hepatology (2022)
Treatment of chronic hepatitis B in sub-saharan Africa: 5-year results of a pilot program in Ethiopia
Authors: Stian Magnus Staurung Orlien, Hailemichael Desalegn, Hanna Aberra, Eyerusalem Mamo, Benon Amare, Sine Grude, Kristina Hommersand, Nega Berhe, Asgeir Johannessen
Journal: Journal of Hepatology (2022)
Building a case for pancreas and liver targeted intereukin-22 therapy in fatty liver disease
Authors: Haressh Sajiir, Kuan Yau Wong, Alexandra Mueller, Sahar Keshvari, Ran Wang, Percival Wiid, Grant Ramm, Graeme Macdonald, John Prins, Michael McGuckin, Sumaira Hasnain
Journal: Journal of Hepatology (2022)
Hepatocellular carcinoma risks of liver fibrosis changes after viral eradication in chronic hepatitis C patients
Authors: Yen-Chun Liu, Cheng Er Hsu, Ya-Ting Cheng, Chung-Wei Su, Chia-Hung Tai, Yi-Cheng Chen, Wei Teng, Rachel Wen-Juei Jeng, Chun-yen Lin, Rong-Nan Chien, Tai Dar-In, I-Shyan Sheen
Journal: Journal of Hepatology (2022)
Prevalence rates and eligibility for antiviral treatment against hepatitis B in Casamance, Senegal
Authors: Victor Arendt, Mame Aisse Thioubou, Kalilou Diallo, Henri Goedertz, Daouda Diouf, Benjamin Sambou, Chabi Bindia, Ousseynou Cisse, Salimata Camara, Noel Manga, Esther CalvoLassoDelaVeiga, Boubacar Diouf
Journal: Journal of Hepatology (2022)
Expandable constrained 6 mm transjugular intrahepatic portosystemic shunt: an alternative approach for high-risk patients?
Authors: Hannah Schneider, Anja Tiede, Alena Friederike Ehrenbauer, Lena Stockhoff, Johanna Luise Charlotte Lorenz, Heiner Wedemeyer, Richard Taubert, Jan Hinrichs, Benjamin Maasoumy
Journal: Journal of Hepatology (2022)
Hemodynamic, molecular, and histological characterization of a toxic liver fibrosis regression model
Authors: Philipp Königshofer, Ksenia Brusilovskaya, Benedikt Hofer, Benedikt Simbrunner, Oleksandr Petrenko, Hubert Scharnagl, Tatjana Stojakovic, Michael Trauner, Philipp Schwabl, Stefan Günther Kauschke, Larissa Pfisterer, Thomas Reiberger
Journal: Journal of Hepatology (2022)
Sequential algorithm of spleen stiffness measured by a dedicated 100 Hz examination and Baveno VII criteria for clinically significant portal hypertension in compensated cirrhosis
Authors: Ruiling He, Chuan Liu, Li Jie, Jianzhong Ma, Ying Guo, Xiaoqing Guo, Shirong Liu, Bo Gao, Ning Liu, Mingkai Chen, Hongwei Zhou, Tianyu Tang, Yu Shi, Shenghong Ju, Yan Huadong, Xiaolong Qi
Journal: Journal of Hepatology (2022)
Outcomes of pregnancy in patients with autoimmune hepatitis in the Netherlands
Authors: Susan Fischer, Elsemieke de Vries, Ynto de Boer, Adriaan Van der Meer, Robert De Man, Johan Kuyvenhoven, Michael Klemt-Kropp, Tom Gevers, E.T.T.L. Tjwa, Edith Kuiper, Marc A.M.T. Verhagen, Philip W. Friederich, Bart Van Hoek
Journal: Journal of Hepatology (2022)
Hepatocellular carcinoma incidence is reduced in cirrhotic chronic hepatitis B patients with HBsAg seroclearance comparing to those with viral suppression
Authors: Rachel Wen-Juei Jeng, Chien-Hung Chen, Hwai-I Yang, Yi-Cheng Chen, Yen-Chun Liu, Chia-Ying Wu, Rong-Nan Chien, Yun-Fan Liaw
Journal: Journal of Hepatology (2022)
Liver transplantation for hepatocellular carcinoma with extended criteria: performance and applicability of the AFP score after official adoption by the French Organ Sharing Organization ABM: 5-year outcomes
Authors: Christophe Duvoux, Mathilde Petiet Dumont, Georges-Philippe Pageaux, Ephrem Salamé, Jérôme Dumortier, Sylvie Radenne, Sébastien Dharancy, Pauline Houssel-Debry, Philippe Bachellier, Laurence Chiche, Francois Durand, Fabrice Muscari, Jean Gugenheim, Filomena Conti, Jean Hardwigsen, Christian Jacquelinet, Corinne Antoine, Norbert Ngongang, Vincent Leroy, Thomas Decaens, Daniel Cherqui, Nadia Oubaya
Journal: Journal of Hepatology (2022)
Transjugular, intra-hepatic portosystemic shunt (TIPS) in elderly patients: preliminary analysis of a multi center retrospective cohort
Authors: Davide Roccarina, Laura Turco, Claudia Campani, Dario Saltini, Silvia Aspite, Vincenza Calvaruso, Umberto Arena, Marco Senzolo, Fabrizio Fanelli, Cristian Caporali, Stefano Gitto, Michele Citone, Chiara Di Bonaventura, Filippo Schepis, Francesco Vizzutti, Oliviero Riggio, Patrizia Burra, Erica Villa, Calogero Camma, Fabio Marra, Marcello Bianchini
Journal: Journal of Hepatology (2022)
Very late relapses in Hodgkin lymphoma treated with chemotherapy with or without radiotherapy: linear pattern and distinct prognostic factors
Authors: Theodoros P. Vassilakopoulos, Evrydiki Kravvariti, Fotios Panitsas, Maria K. Angelopoulou, Athanasios Liaskas, Flora N. Kontopidou, Xanthoula Yiakoumis, Eleni Variami, Maria N. Dimopoulou, Marina P. Siakantaris, John V. Asimakopoulos, Maria Arapaki, Maria Dimou, Panagiotis Diamantopoulos, Sotirios Sachanas, Chrysovalantou Chatzidimitriou, Marina Belia, Elianna Konstantinou, George Boutsikas, Kyriaki Petevi, Alexandros Kanellopoulos, Styliani Kokoris, Marie-Christine Kyrtsonis, Nora-Athina Viniou, Eleftheria Lakiotaki, Gerasimos Tsourouflis, Penelope Korkolopoulou, Kostas Konstantopoulos, Panayiotis Panayiotidis, Gerassimos A. Pangalis
Journal: Blood Cancer Journal (2022)
Limited value of HBV-RNA levels for the prediction of relapse after discontinuation of nucleos (t)ide analogue therapy in HBe antigen negative chronic hepatitis B patients
Authors: Valerie Ohlendorf, Maximilian Wübbolding, Christoph Hoener zu Siederdissen, Birgit Bremer, Katja Deterding, Heiner Wedemeyer, Markus Cornberg, Benjamin Maasoumy
Journal: Journal of Hepatology (2022)
Outcome predictors of gemcitabine-based or fluoropyrimidine-based chemotherapy for unresectable intrahepatic cholangiocarcinoma
Authors: Chen-Ta Chi, I-Cheng Lee, Ming-Huang Chen, Pei-Chang Lee, Yi-Ping Hung, Ming-Chih Hou, Yee Chao, Yi-Hsiang Huang
Journal: Journal of Hepatology (2022)
HBV screening in west african migrant community and faith-based organizations increases HBV vaccination among this high-risk population in greater Barcelona, Spain
Authors: Camila Picchio, Ariadna Rando-Segura, Emma Fernandez, Nélida López, Silvia Gómez Araujo, Daniel Kwakye Nomah, Omar Diatta, Sergio Rodriguez-Tajes, Sabela Lens, Xavier Forns, Francisco Rodríguez-Frías, Maria Buti, Jeffrey Lazarus
Journal: Journal of Hepatology (2022)
Carvedilol is associated with superior hemodynamic response and rebleeding rates in comparison to propranolol in secondary prophylaxis of variceal bleeding
Authors: Mathias Jachs, Lukas Hartl, Benedikt Simbrunner, David JM Bauer, Rafael Paternostro, Lorenz Balcar, Benedikt Hofer, Nikolaus Pfisterer, Michael Schwarz, Bernhard Scheiner, Albert Stättermayer, Matthias Pinter, Michael Trauner, Mattias Mandorfer, Thomas Reiberger
Journal: Journal of Hepatology (2022)
Liver inflammation activity in autoimmune hepatitis patients with normal ALT and IgG levels
Authors: Chuanwu Zhu, Jiacheng Liu, Jian Wang, Huali Wang, Yilin Liu, Yiguang Li, Li Zhu, Weimao Ding, Yuanwang Qiu, Yongfeng Yang, Jie Li, Rui Huang, Chao Wu
Journal: Journal of Hepatology (2022)
Type 2 diabetes and religious fasting: effects on metabolism and liver steatosis
Authors: Svenja Sydor, Ender Engin, Mustafa Özcürümez, Anja Figge, Josef Pospiech, Andreas Jähnert, Jan Best, Wing-Kin Syn, Ali Canbay, Lars Bechmann, Paul Manka
Journal: Journal of Hepatology (2022)
Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects
Authors: Neil A. Robertson, Eric Latorre-Crespo, Maria Terradas-Terradas, Jorge Lemos-Portela, Alison C. Purcell, Benjamin J. Livesey, Robert F. Hillary, Lee Murphy, Angie Fawkes, Louise MacGillivray, Mhairi Copland, Riccardo E. Marioni, Joseph A. Marsh, Sarah E. Harris, Simon R. Cox, Ian J. Deary, Linus J. Schumacher, Kristina Kirschner, Tamir Chandra
Journal: Nature Medicine (2022)

Clonal hematopoiesis of indeterminate potential (CHIP) increases rapidly in prevalence beyond age 60 and has been associated with increased risk for malignancy, heart disease and ischemic stroke. CHIP is driven by somatic mutations in hematopoietic stem and progenitor cells (HSPCs). Because mutations in HSPCs often drive leukemia, we hypothesized that HSPC fitness substantially contributes to transformation from CHIP to leukemia. HSPC fitness is defined as the proliferative advantage over cells carrying no or only neutral mutations. If mutations in different genes lead to distinct fitness advantages, this could enable patient stratification. We quantified the fitness effects of mutations over 12 years in older age using longitudinal sequencing and developed a filtering method that considers individual mutational context alongside mutation co-occurrence to quantify the growth potential of variants within individuals. We found that gene-specific fitness differences can outweigh inter-individual variation and, therefore, could form the basis for personalized clinical management.
Humoral and cellular immune responses to wild-type and omicron (B.1.1.529) SARS-CoV-2 variants following a fourth COVID-19 vaccination in liver transplant recipients and patients with autoimmune hepatitis
Authors: Stavros Dimitriadis, Georgina Meacham, Sophie Irwin, Victoria Walker, Sam Murray, Zixiang Lim, Thomas Marjot, Jack Satsangi, Eleanor Barnes
Journal: Journal of Hepatology (2022)
Lean non-alcoholic fatty liver disease patients from the global NASH registry
Authors: Zobair Younossi, Yusuf Yılmaz, Ming-Lung Yu, Vincent Wai-Sun Wong, Marlen Castellanos-Fernandez, Vasily Isakov, Ajay Kumar Duseja, Nahum Méndez-Sánchez, Yuichiro Eguchi, Elisabetta Bugianesi, Patrizia Burra, Jacob George, Jian-Gao Fan, George Papatheodoridis, Wah-Kheong Chan, Khalid Alswat, Saeed Sadiq Hamid, Ashwani Singal, Manuel Romero Gomez, Stuart C Gordon, Stuart Roberts, Mohamed El Kassas, Marcelo Kugelmas, Janus Ong, Saleh Alqahtani, Mariam Ziayee, Brian Lam, Issah Younossi, Andrei Racila, Linda Henry, Maria Stepanova
Journal: Journal of Hepatology (2022)
Hepatitis B pre-genomic RNA differentiates HBeAg-negative disease from infection: time to refine disease stages with new biomarkers?
Authors: Bo Wang, Mark Anderson, Natalie Bolton, Christiana Moigboi, James Lok, Gavin Cloherty, Ivana Carey, Geoffrey Dusheiko, Kosh Agarwal
Journal: Journal of Hepatology (2022)
Pregnancy as a unique opportunity to identify NAFLD in women: a prospective assessment
Authors: Tatyana Kushner, Shaelyn O’Hara, Marcia Lange, Carin Carroll, Emma Rosenbluth, Pamela Argiriadi, Rachel Meislin, Joanne Stone, Keith Sigel, Rhoda Sperling, Scott Friedman, Norah Terrault
Journal: Journal of Hepatology (2022)
NanoView EV Chip-based profiling in liver cancer differentiation-HCC from intrahepatic CCA-small EVs vs large EVs
Authors: Bingduo Wang, Tudor Mocan, Sabine K. Urban, Adelina Horhat, Dominik Zölzer, Zeno Sparchez, Alex Shephard, Ben Owen, Arnulf Willms, Ingo G. Schmidt-Wolf, Maria Angeles Gonzalez-Carmona, Christian Strassburg, Veronika Lukacs-Kornek, Miroslaw Kornek
Journal: Journal of Hepatology (2022)
Inclusion of body composition parameters in MELD score leads to optimization of predictive performance in patients with cirrhosis
Authors: Maryam Ebadi, Rhonda J. Rosychuk, Elora Rider, Abha DunichandHoedl, Maryam Motamedrad, Rahima A. Bhanji, Aldo J Montano-Loza
Journal: Journal of Hepatology (2022)
Rethinking the management of chronic hepatitis B in the context of rural sub-saharan Africa: results from a social justice mixed methods study in rural Senegal (the AmBASS-PeCSen study)
Authors: Marion Coste, Cilor Ndong, Aldiouma Diallo, Assane Diouf, Sylvie Boyer, Jennifer Prah
Journal: Journal of Hepatology (2022)
Molecular characterization of metabolic associated fatty liver disease as an immune-mediated inflammatory disease: IMID associated fatty liver disease
Authors: Enrique García-Nieto, Juan Carlos Rodriguez-Duque, Paula Iruzubieta, Agustin García-Blanco, Coral Rivas, María Luisa Cagigal, Javier Rueda-Gotor, Montserrat Rivero, Susana Armesto, Marcos Antonio Gonzalez-Lopez, Carlos Duran-Vian, Anna Esteve Codina, Marta Gut, Jose Pedro Vaqué, Javier Crespo, María Teresa Arias Loste
Journal: Journal of Hepatology (2022)