POS0851 FREQUENCY OF METABOLIC SYNDROME AND ITS RELATIONSHIP WITH DISEASE CHARACTERISTICS IN PATIENTS WITH SYSTEMIC SCLEROSIS
Authors: Ü. Özmen, E. Er Gülbezer, B. Barutçuoğlu, F. Yargucu
Journal: Annals of the Rheumatic Diseases (2022)

Background Although the frequency of metabolic syndrome (MetS) has been found to increase in many rheumatological diseases such as rheumatoid arthritis, systemic lupus erythematosus, few studies have been conducted on the frequency of MetS in systemic sclerosis (SSc), and the results are inconsistent. Objectives In our study, we aimed to investigate the frequency of MetS in patients with SSc and its relationship with disease characteristics including organ involvement. Methods In a cross-sectional, single-center study, 76 patients who applied to our outpatient clinic between July and September 2021 were included in the study. MetS diagnoses were determined according to anthropometric measurements, lipid parameters, blood pressures, and NCEP ATP 3 criteria, and its relationship with SSc end-organ involvement and disease characteristics was examined. Results MetS was detected in 37 (48.7%) of 76 patients. Systolic and diastolic blood pressure, waist circumference, height, body mass index, LDL, triglyceride, and fasting blood glucose mean were found to be statistically significantly higher in patients with MetS (p&lt;0.05). In addition, HDL was found to be significantly lower in patients with MetS diagnosis than in patients without MetS (p&lt;0.05). While no significant relationship was found between MetS and SSc end-organ involvement, SSc disease activities (RAI, SCTC-DI), disease duration, a significant statistical relationship was found between MetS and modified Rodnan skin score (mRSS). It was found that patients with MetS had lower mRSS (p:0.019). According to ROC analysis, the mRSS cut-off point that predicting the presence of MetS was mRSS ≤11 (specificity: 84%, sensitivity: 45.95%, AUC: 0.656, p: 0.014). No statistically significant correlation was found in the comparison with MetS risk factors for mRSS ≤11. Conclusion In our study, the frequency of MetS in patients with SSc was found to be lower than in the same age group in Turkey MetS prevalence studies. The frequency of Mets in our study is thought to be due to age and gender dominance rather than SSc itself. Although mRSS was found to be significantly lower in patients with MetS, its sensitivity to predict MetS was found to be low. MetS is less common in patients with high mRSS; It is thought that cachexia due to inflammation, loss of appetite, and malnutrition due to GI involvement may have been effective. References [1]Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Circulation. 2005;112(17):2735–52. [2]Metabolic syndrome, autoimmunity and rheumatic diseases. Pharmacol Res.2018;133:277–88. [3]Frequency of Metabolic Syndrome in Female Patients with Systemic Sclerosis: A Preliminary Report. Jrd. 2012;19(5):262–9. [4]Metabolic syndrome and adipokine levels in systemic lupus erythematosus and systemic sclerosis. Clin Rheumatol. 2021 Oct;40(10):4253-4258 [5]Prevalence of metabolic syndrome and insulin resistance in system sclerosis. Rev Med Inst Mex Seguro Soc. 2015;53(4):476–83. [6]Serum adipokines levels in patients with systemic sclerosis: A meta-analysis. Mod Rheumatol. 2017;27(2):298–305. Disclosure of Interests None declared