tbuckley/cabot-search huggingface dataset:
Awards, Appointments, Announcements
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Awards, Appointments, Announcements Get access JNCI: Journal of the National Cancer Institute, Volume 86, Issue 12, 15 June 1994, Pages 898–900, https://doi.org/10.1093/jnci/86.12.898 Published: 15 June 1994
Multiphasic Screening: Panacea or Diagnostic Nightmare?
Authors: Alvin M. Ring
Journal: JAMA (1985)

From its inception, multiphasic screening captured the imagination of the medical profession. Glowing articles depicted the vast amounts of unsuspected disease that could be diagnosed early, often in preclinical stages, with dramatic declines in the need for hospitalization and tremendous cost savings. Unfortunately, the early enthusiasm was clearly overstated. Multiphasic screening turned out to be a mixed blessing. Elsewhere in this issue,<sup>1</sup>Donald M. Berwick discusses screening in health fairs, a most appropriate topic at a time of focus on the burgeoning costs of medical care. Berwick states that in 1984, "health fairs across the nation performed 1.5 million measurements of height and weight, 300,000 tests for glaucoma, 200,000 hearing screens, and nearly 20 million blood chemistry tests." Health fairs thus have substantial potential to aid (or hurt) patients and to support (or diminish) physicians' efforts and thereby impact medical costs. In a large sample of participants in health
The General Medical Journal in Clinical Medicine
Authors: Martin Ware
Journal: New England Journal of Medicine (1968)

TO me clinical medicine is the heart of medicine — what it is all about. My guess is that Joe Garland would approve of this sentiment. Beyond all the contributions of medical research, advances in public health and technical achievements of the laboratory lie the health and happiness of the individual patient. Medicine is seen in its essence when a patient goes to his doctor for advice —when they meet together in consultation. All the doctor's training and experience have gone to prepare him for this moment, and a formative element in this preparation will have been his reading of . . .
Measles vaccination as a risk factor for inflammatory bowel disease
Authors: Paddy Farrington, Elizabeth Miller, K.C. Calman, PhilipD. Minor, ThomasT. MacDonald, David Miller, Adrian Renton, Tony Baxter, John Radford, N.P. Thompson, S.M. Montgomery, R.E. Pounder, A.J. Wakefield
Journal: The Lancet (1995)
The Treatment of Cancer in an Aging Population
Authors: Jules E. Harris
Journal: JAMA (1992)

America is aging. The demographic data to support this statement are convincing and compelling.<sup>1</sup>At present, the population aged 55 years and older is over one fifth of the total population. By 2010, one fourth of the total US population (74.1 million persons) is projected to be at least 55 years old; one in seven Americans will be 65 years or older (39.3 million) and the number of persons aged 85 years and older will be 2.4% of the total population (6.8 million). Within the over-65 group, the most rapidly growing subgroup is the "oldest old" (those over 85 years old). Cancer is a disease that affects primarily older persons.<sup>2</sup>As our aging population increases in size, the incidence of cancer will rise. The growing elderly population will show a greater prevalence of cancer. Over half of all cancer is diagnosed in those over the age of 65
The role of 16, 16-dimethyl prostaglandin E2 on the intrahepatic biliary branches in dogs
Authors: Tetsuo Ohta, Takukazu Nagakawa, Yutaka Yoshimitsu, Hiromi Sanada, Luis Fonseca, Itsuo Miyazaki, Tadashi Terada
Journal: Hepatology (1993)

We studied the effects of the oral administration of a stable prostaglandin E2 analog, 16,16-dimethyl prostaglandin E2, on the intrahepatic biliary branches in a canine model. Obstructive cholestasis with a bacterial infection was induced surgically in two liver lobes in healthy mongrel dogs, and 16,16-dimethyl prostaglandin E2 was administered orally. We examined the morphological changes in the intrahepatic biliary branches and quantitatively estimated density of mucus-producing glandular elements in the ductal wall by counting these glands per unit area. Dogs treated with 16,16-dimethyl prostaglandin E2 (group 1) demonstrated fibrous thickening of the ductal wall, moderate infiltration by inflammatory cells and severe adenomatous hyperplasia of the bile duct epithelium, including striking proliferation of the mucous glands. The mean number of these mucous glands per unit area (4 mm 2 ) was 43.0 ± 9.0 (mean ± S.D.; range = 36 to 56). In contrast, in a control group whose members did not receive 16,16-dimethyl prostaglandin E2 (group 2), the mean number of mucous glands per unit area was 19.4 ± 8.0 (range = 10 to 29), significantly lower than that in group 1, although histological examination revealed chronic inflammation in the region of the large bile duct similar to that in group 1. These findings suggest that the increase in the number of mucous glands that typically occur in the setting of bile stasis and biliary infection is enhanced by 16,16-dimethyl prostaglandin E2. (Hepatology 1993;17:1062-1065.)
Massive Early Proteinuria Following Renal Homotransplantation
Authors: George M. Abouna
Journal: JAMA (1973)

Massive proteinuria (more than 40 gm/24 hr) occurred in a young man almost immediately after renal transplantation with an intrafamilial donor. The proteinuria, accompanied by severe hypoalbuminemia and extensive peripheral edema, persisted for several months and then subsided spontaneously. Histological and immunofluorescent examination of renal tissue showed no evidence of rejection or recurrent nephritis. We attribute the proteinuria to an increase in venous pressure within the kidney caused by ligation of one of two large renal veins draining the donor organ. The spontaneous remission is attributed to the development of adequate collateral venous channels, which acted to relieve the venous hypertension. When a renal homograft has two veins of similar size, both must be used for anastomosis.
Satellite and commercial medical clinics. Report of the Board of Trustees: Part II
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgery of the Ambulatory Patient
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Estrogen Profiles of Primiparous and Nulliparous Women in Athens, Greece&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1980)

Urine estrogens of 144 primiparous women and 122 nulliparous women of similar age were measured. The primiparae were at least 6 months post pregnancy. The ratio of the estriol concentration to the sum of the concentrations of estrone and estradiol (the estriol ratio) was higher among primiparous women under 25 years of age than among nulliparou. s women of the same age. The difference was greater in specimens collected in the luteal phase of the menstrual cycle than in those collected in the follicular phase and was statistically significant (P>0.05. one-tailed t-test) only in the luteal phase. The high estriol ratios of the primiparous women did not decline with increasing interval after pregnancy, at least up to 24 months. Among the younger women, significantly lower levels of pregnanediol, suggestive of a higher frequency of anovular menstrual cycles, were also seen in the nulliparous women. The findings were consistent with the hypothesis that the protective effect against breast cancer of a full-term pregnancy at an early age operates either through a change in the pattern of estrogen metabolism induced by the pregnancy or through a change in the frequency of ovular cycles.
Familial Pseudohypoparathyroidism Presenting in Adult Life<sup>1</sup>
Authors: D V Hamilton
Journal: Journal of the Royal Society of Medicine (1980)

Three members of one family who presented in adult life with pseudohypoparathyroidism are reported. The importance of screening members of the family of patients with pseudohypoparathyroidism is stressed. Higher doses of 1α-hydroxycholecalciferol are required than in idiopathic or surgical hypoparathyroidism or in chronic renal failure.
Measles, a Renewed Challenge
Authors: ASHER J. Finkel
Journal: JAMA (1971)

When Rhazes (860-932 AD), a physician living in the Eastern Caliphate in Persia, distinguished measles from smallpox, he provided the first accurate description of an ancient and widespread infectious disease. A relatively mild disease primarily affecting children in developed countries, it can be serious and devastating in less-well-developed lands and can be the cause of serious epidemics among nonimmune adults in isolated populations. Despite its relative mildness in recent years in countries such as the United States, measles is known to have a number of serious complications such as pneumonia, severe bronchitis, and bronchiolitis; otitis media; and encephalitis, mental retardation, behavior changes, and motor disturbances.<sup>1</sup>Rarer complications include purpura, corneal ulceration, pneumomediastinum, and even appendicitis. Before the licensure of an attenuated live virus vaccine in 1963, more than 4 million cases of measles are estimated to have occurred annually in the United States of which 400,000 were reported. At
The use of perichondrial cutaneous grafts to repair defects of the lower third of the nose
Authors: H.M. GLOSTER, D.G. BRODLAND
Journal: British Journal of Dermatology (1997)

The reconstruction of surgical defects on the nasal tip and nasal ala which require both skincoverage and underlying support is often a complex surgical problem. The perichondrial cutaneous graft (PCCG) is a composite graft of skin and perichondrium harvested from the conchal bowl of the ear. It is an excellent alternative to full‐thickness skin grafts and local flaps for reconstructing defects of the lower third of the nose. This composite graft, which is composed of epidermis, dermis, a small amount of subcutaneous tissue, and the underlying perichondrium, yields excellent cosmetic and functional results in a simple, single‐stage, out‐patient procedure. This article describes and illustrates the repair of surgical defects on the nasal tip and nasal ala using the PCCG.
Williams' Obstetrics: A Textbook for the Use of Students and Practitioners
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long term pharmacotherapy of depression
Authors: D. Gamble, J. Thakore, R. Tobiansky, C. Manning, J G. Edwards
Journal: BMJ (1998)

Guidelines for cervical screening await scientific evaluationEditor-In a news item about cervical screening in England 1 Wise refers to a report by the National Audit Office. 2 The office is particularly critical of serious failings in the interpretation of cervical smears in a small number of laboratories.The laboratory at the Hospital of St Cross in Rugby is included among these laboratories.In fact, a massive rescreening exercise at the hospital did not find any serious errors of interpretation, and the original reports were considered to be substantially correct and within the accepted operating limits of the smear test.The National Audit Office and the public assume that any deviation from the national guidelines for reporting rates represents mistakes by the laboratory.It is therefore interesting that, although the results at the hospital in Rugby were outside these guidelines, no serious errors were identified.This raises the question of whether the guidelines are an appropriate measure of laboratory performance.The guidelines themselves have come under considerable criticism in the pathology literature because of the lack of scientific evidence on which they are based. 3 One of their own authors has been particularly outspoken on the subject. 4 Though some of these arguments may seem of academic interest, cytology departments are being forced to close or merge as a result of the guidelines, which await scientific evaluation.Many staff feel threatened by the prescriptive way in which the guidelines have been introduced and applied and by the lack of understanding by the lay public and media of the limitations of the smear test.The incidence of and mortality from cervical cancer in the United Kingdom have shown accelerated falls since the introduction of organised screening (J Patnick, NHS cervical screening programme information sheet, 21 Nov 1996).Of course there is room for improvement, but it is ironic that the publication of various reports designed to improve the service could lead to its eventual collapse through staff leaving the profession.
Awards, Appointments, Announcements
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Awards, Appointments, Announcements Get access JNCI: Journal of the National Cancer Institute, Volume 83, Issue 8, 17 April 1991, Pages 539–540, https://doi.org/10.1093/jnci/83.8.539 Published: 17 April 1991
PDQ (Physician Data Query)
Authors: Howard Hochster
Journal: JNCI Journal of the National Cancer Institute (2015)

NEWS | 7 of 8"We've shied away from the FOLFOXFIRI regimen for most patients because of the additional toxicity," Meropol said.Patients in the TRIBE trial had a median age of 60 years-and those older than 75 years were excluded-whereas the average CRC patient is 72 years.Patients with a good performance status were also overrepresented."My approach is to use more intense treatment when needed and back off when the tumor is controlled," Grothey said.In the United States, a maintenance therapy approach is common with no finite number of chemotherapy treatment cycles."We recognize that cancer is a chronic disease that requires chronic therapy.For colorectal cancer, we can keep patients on therapy longer because we have learned how to dose the available therapies appropriately to both mitigate toxicity and to keep the tumors controlled," Grothey said.According to
Phenacetin Abused
Authors: N. G. Sanerkin
Journal: BMJ (1964)

Leading ArticlesILJoIURNAL 997normal response to glucagon four days after the last dose of tolbutamide.Possibly the usual hypoglycaemic action of the sulphonylureas might be potentiated by leucine9 10 or other unknown factors.The results of tests of adrenal and pituitary function and the sensitivity of the patient to insulin have all been normal.5Oral sulphonylurea compounds are given to large numbers of diabetic patients and for ill-established reasons to a few non-diabetics.It is therefore important to recognize that they may cause profound and protracted hypoglycaemia, especially in view of the risks of hypoglycaemic coma.Once diagnosed, coma must be treated by vigorous and sustained glucose therapy, though it may not always prevent the patient's death.
Consultants' new contract
Authors: W. Westlake
Journal: BMJ (2002)

# Shurely shome mishtake? {#article-title-2} EDITOR—I think that there must be a mistake and I have downloaded the wrong contract from the BMA's website.1 The one I downloaded offers a 4% pay rise in return for a 16% increase in my clinical workload. Further pay rises are at the whim of my managers, to be paid five years in arrears provided that I meet conditions over which I have no control or work unpaid overtime. The contract I downloaded is a licence to enable my managers to order me in for routine surgery and clinics on weekday evenings, Saturdays, and Sundays, for no extra pay, while paying me £1 an hour to be on- call at other times. Could someone please send me the other contract that Peter Hawker and the BMA are hailing as a resounding victory for my colleagues and me2 while I vote no to what is clearly a different contract. 1. 1.↵Consultant contract: framework. Available at: www.bma.org.uk/ap.nsf/Content/__Hub+ccsc+contract (accessed 3 July 2002). 2. 2.↵1. Hargreaves S .Government makes U turn on private practice ban.BMJ2002; 324:1473. (22 June.) [OpenUrl][1][CrossRef][2] # So called victory in private practice obscures real contractual problems {#article-title-4} EDITOR—Reports on the proposed consultant contract have focused too heavily on the concessions obtained over private practice and the headline figure of a 20% pay rise.1 The pitfalls of the contract far outweigh this victory. Firstly, few doctors will immediately, or in the near future, get a 20% rise in pay. Essentially we are being promised a 20% rise staged over 20 years, or 1% a year. For many this rise will be offset in part by loss of domiciliary fees, category 2 work, and the loss of intensity payments. My own pay rise will be 2-3%—hardly a princely sum given I work full time for the NHS. Secondly, the new contract seeks to make evening working up to 10 pm and weekend morning work an acceptable part of the working week, remunerable at standard rate. I find this appalling. Junior doctors have spent years fighting to be … [1]: {openurl}?query=rft_id%253Dinfo%253Adoi%252F10.1136%252Fbmj.324.7352.1473%252Fa%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1136/bmj.324.7352.1473/a&link_type=DOI
Doctor as Patient Advocate
Authors: William S. Hotchkiss
Journal: JAMA (1987)

I come before you tonight with feelings of pride, humility, enthusiasm, resolve, and deep respect. I respect the many outstanding physicians who have led the AMA before me, and each of you for your selfless commitment in working on behalf of the health of the American people. But most of all, I respect the institution of medicine and what it stands for—health, dignity, service, and excellence. For more than 100 years, the AMA has dedicated itself to preserving those fundamental ideals of American medicine, and I'm proud to be a part of that tradition. I like to remind people that the AMA is a caring organization of service to the American people. As physicians, we are not here to do battle with the government for our self-interests, we are not here to become leaders of corporate America, and we are certainly not here to amass wealth; we are here for
Methemoglobinemia From Overdose of Nitroglycerin
Authors: John B. Marshall
Journal: JAMA (1980)

<h3>To the Editor.—</h3> Nitrites and nitrates are well-recognized causes of acquired methemoglobinemia.<sup>1</sup>Nitroglycerin has been reported to cause methemoglobinemia in animals.<sup>2</sup>We report on a patient in whom we believe methemoglobinemia developed from an accidental overdose of nitroglycerin. <h3>Report of a Case.—</h3> An 80-year-old man with a history of angina pectoris was admitted because of chest pain and shortness of breath. During the two days before admission, he had many episodes of chest pain with minimal exertion and at rest. Three hours before admission continuous chest pain began. The patient took one hundred 0.4-mg nitroglycerin tablets during a 36-hour period before admission. His other medications included isosorbide dinitrate, 10 mg sublingually four times a day; nitroglycerin 2% ointment, 5.1 cm (2 in) at bedtime; propranolol hydrochloride, 40 mg four times a day; and furosemide, 40 mg every day. There was no history of cyanosis. Physical examination showed an
SPECIES OF HYMENOLEPIS AS HUMAN PARASITES
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal