POS1542-HPR QUALITY OF LIFE AND PHYSICAL FUNCTIONING OF PATIENTS WITH JUVENILE IDIOPATHIC ARTHRITIS FAST TRANSLATE ICON TRANSLATE FAST TRANSLATE ICON TRANSLATE
Authors: L. Bohmat, N. Shevchenko, A. Fadieieva, V. Nikonova
Journal: Annals of the Rheumatic Diseases (2022)

Background Quality of life (QoL) due to World Health Organization (WHO) is an individual’s perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns. QoL can be decreased during chronic illnesses, including juvenile idiopathic arthritis (JIA). This severe chronic disease of childhood afflicts both joints and body`s system inducing various comorbid conditions, among which eye damage (uveitis) is the most common 1 . Considering the fact of involved joints it was set up that physical functioning (PF) shows the lowest values in some studies, which is associated with joint damage, activity, and duration of the disease 2 . Objectives To establish the overall level of QoL and physical functioning in patients with JIA, considering the subtype of the disease, duration and the therapy complex. Methods The study involved 118 patients with JIA, among which 47 had polyarticular subtype, 43 had oligoarticular one, 28 were with uveitis-associated (JIA-u) subtype. The investigation included 77 girls and 41 boys in age from 2 till 18 years old. The therapy by methotrexate was provided in 112 patients, among them 30 had MTX with immunobiological therapy (29 adalimumab, 1 – tocilizumab), 6 – sulfasalazine. The disease duration due to disease subtype in polyarthritis was (49,2±6,7), oligoarthritis – (35,4±4,2), JIA-u – (76,8±10,2) months. Disease activity was assessed using the JADAS27 questionnaire, functional state (FS) according to CHAQ and QoL according to PedsQLTM 4.0 Generic Core Scales. Results It was found that high JIA activity was observed in 31 (26.2%) patients, equally often in all subgroups of children. FS did not show a significant decrease either in the whole group or in each of the arthritis subgroups. The overall indicator of QoL in children with JIA was reduced in the whole group (71.2±1.4 and 72.9±1.4 per week and month). There was no significant difference between the QoL indicators of boys and girls. The polyarticular subtype showed the lowest results in QoL and PF, especially in children in the first year of the disease. They also turned out to be worse in children with JIA-u with the disease from one to three years (QoL – 63,3±2,6*; PF – 66,6±3,9) The highest level of the physical component of QoL was observed in children with oligoarthritis older than 14 years (84,9±4,7) and in children under 8 years of age in the JIA-u group (96,8±1,8). There was no significant effect on the physical indicators of QoL of the start treatment timing. (р≤0,05). Finally, the strong correlation was determined between QoL and PF (r=-0,842; р≤0,05). Conclusion A decrease in QOL and its physical component is typical for children with different types of JIA (oligoarticular, polyarticular, and JIA-y). It has been established that children with polyarticular subtype of arthritis have the greatest decrease in QoL and physical functioning. References [1]Sen E, Ramanan A. Juvenile idiopathic arthritis-associated uveitis. Best Practice &amp; Research Clinical Rheumatology. 2017;31(4):517-534. DOI: 10.1016/j.berh.2018.01.002 [2]McDonald J, Cassedy A, Altaye M, Andringa J, Cooper A, Drews-Botsch C et al. Comprehensive assessment of quality of life, functioning and mental health in children with juvenile idiopathic arthritis and non-infectious uveitis. Arthritis Care &amp; Research. 2021. DOI: 10.1002/acr.24551 Disclosure of Interests None declared