tbuckley/cabot-search huggingface dataset:
Venography
Authors: WILLIAM J. WILLIAMS
Journal: Circulation (1973)

Venographyp ULMONARY embolism is a major cause of morbidity and mortality in patients after surgery, in debilitated patients, and in childbirth.Nearly all pulmonary emboli arise from thro}mbi in the leg veins, and the difficulties in the clinical recognition of venous thrombosis have been empha- sized repeatedly.Clinical evaluation detects less than one half of the cases of venous thrombosis,1' 2 and in one report only 5% of patients with fatal pulmonary emboli had clinical evidence of leg-vein thrombosis.A number of procedures for the diagnosis of this condition have been advocated, of which four have recently received the most attention.These are venography,4-7 radioactive fibrinogen uptake,8 impedance plethysmography,9
Banquet Piece
Authors: M. Therese Southgate
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Small Arterial Homografts: Results of Ten-Year Follow-up
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Values for upper limit of normal should be given for liver enzymes #
Authors: Michael L. Schilsky, William Lee, Frank Wiands
Journal: Hepatology (2009)

We thank Dr. Manesis for his response and query raising the important point of normal ranges for laboratory values and their possible effect on the results of our study.1 The data for liver tests collected from our patients in both the control group and the patient group with Wilson disease were recorded at many different clinical sites at which the upper limits of normal differed. The only normalized value collected by this study was the international normalized ratio. Although we were also initially concerned about this problem, we found that despite the lack of uniformity for laboratory testing ranges or normalization of the test results to controls, the analyzed data showed clear cutoffs on analysis by receiver operated curves for our study groups. With respect to the age differences for laboratory ranges, we agree that the results for the alkaline phosphatase measurements would be the most dramatically affected. However, even with the inclusion of some pediatric patients in the Wilson disease group [four patients; 14 (n = 2), 15, or 17 years old] and none in the controls, only one of the pediatric patients had such a higher alkaline phosphatase value that the ratio of alkaline phosphatase to bilirubin was greater than 1 (it was 3.72); this still permitted a clear cutoff value of <4 in comparison with controls with acute liver failure of other etiologies (see Fig. 2 in Korman et al.1). We did not find differences in the range of laboratory tests or results for this study when the groups were analyzed by sex or age. Therefore, despite all the limitations inherent in using data from multiple laboratory sites and across sex and age, we believe that the results of our study are extremely applicable to our clinical practices. Michael L. Schilsky M.D.*, William Lee M.D.*, Frank Wiands Ph.D.*, * Weill Cornell Medical Center New York, NY.
Two Drugs for Weight Loss
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fifteenth Biannual Report of the Cochrane Haematological Malignancies Group--Focus on Non-Hodgkin's Lymphoma
Authors: M. Rancea, A. Will, P. Borchmann, I. Monsef, A. Engert, N. Skoetz
Journal: JNCI Journal of the National Cancer Institute (2013)

This fifteenth biannual report of the Cochrane Haematological Malignancies Group (CHMG) highlights recently published randomized controlled trials (RCTs) in the field of hemato-oncology, covering the publication period from October 2011 to May 2012. Implications for clinical practice and methodological aspects are the main principles for selecting trials for this report. Studies were identified by electronic search of MEDLINE using a broad search filter that covers all topics in hemato-oncology combined with a highly sensitive search filter for randomized trials ( Cochrane Handbook for Systematic Reviews of Interventions ).
The Effects of Weight Loss on Blood Pressure
Journal: Annals of Internal Medicine (2001)

Summaries for Patients2 January 2001The Effects of Weight Loss on Blood PressureSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-1-200101020-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?High blood pressure (hypertension) puts people at risk for heart attacks and strokes. Being overweight contributes to hypertension. It is well known that overweight persons with hypertension can lower their blood pressure by losing weight. It is not known, however, whether weight loss will lower blood pressure or prevent hypertension in overweight adults whose blood pressure is on the high side of normal to begin with. Normal blood pressures are less than 140/90 mm Hg. The first number is called systolic blood pressure, and the second number is ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Long-Term Weight Loss and Changes in Blood Pressure: Results of the Trials of Hypertension Prevention, Phase II.” It is in the 2 January 2001 issue of Annals of Internal Medicine (volume 134, pages 1-11). The authors are VJ Stevens, E Obarzanek, NR Cook, I-M Lee, LJ Appel, D Smith West, NC Milas, M Mattfeldt-Beman, L Belden, C Bragg, M Millstone, J Raczynski, A Brewer, B Singh, and J Cohen.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLong-Term Weight Loss and Changes in Blood Pressure: Results of the Trials of Hypertension Prevention, Phase II Victor J. Stevens , Eva Obarzanek , Nancy R. Cook , I-Min Lee , Lawrence J. Appel , Delia Smith West , N. Carole Milas , Mildred Mattfeldt-Beman , Lorna Belden , Charlotte Bragg , Marian Millstone , James Raczynski , Amy Brewer , Bali Singh , Jerome Cohen , and Metrics 2 January 2001Volume 134, Issue 1Page: I-65KeywordsBlood pressureGraduate medical educationHypertensionMyocardial infarctionOverweightPatientsPrimary hypertensionStrokeSystolic pressureWeight loss ePublished: 2 January 2001 Issue Published: 2 January 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Posters
Authors: F. Frutos, C. Nuñez, P. Garrido, J. M. Lorenzo, M. Aranda, P. Revuelta, C. Chinea, M. Rico, J. Ibáñez-Nolla, M. A. León-Regidor, R. M. Díaz-Boladeras, F. García-Hernández, M. Nolla-Salas, J. M. Sirvent, A. Torres, M. El-Ebiary, P. Castro, J. de Batlle, J. G. de Velasco, A. Alvarez, A. Bonet, M. L. Thomas, H. A. McLure, N. Soni, A. P. Roberts, B. F. Azadian, S. M. Tibby, I. U. Cheema, S. Cox, W. R. Gransden, I. A. Murdoch, J. Tayoro, A. Legras, P. F. Dequin, E. Hazouard, D. Perrotin, R. Anglès, F. J. de Latorre, A. Ferrer, M. Palomar, M. J. Burgueńo, M. D. Bosque, T. Pont, B. Bermejo, J. L. Melgar, C. Chamorro, M. A. Romera, J. M. Borrallo, R. Ruiz de Luna, N. De la Calle, C. Sousa-Dias, J. A. Paiva, A. Costa Pereira, T. Ribeiro, J. Gomes, E. Carmo, I. Gaspar, I. Simões, E. Monteiro, J. L. Neves, P. Abecasis, F. Álvarez-Lerma, M. A. de la Cal, J. Insausti, P. Olaechea, N. Anđelić, O. Ćosić, M. Risović, K. Todorović, V. Đukić, A. Karamarković, A. Ricart, F. Garrigosa, A. Diaz Prieto, T. Casanovas, P. Rodriguez, F. J. Avila, M. Pujol, X. Ariza, E. Shunko, O. Polishchuk, O. Kostiuk, O. Poluliakh, M. Nys, P. Damas, D. Ledoux, P. De Mol, P. Melin, M. Lamy, D. Ivanović, R. Radonić, V. Gaŝparović, M. Merkler, M. Gjuraŝin, A. van ’t Veen, D. Gommers, J. W. Mouton, J. A. J. W. Kluytmans, B. Lachmann, F. Adnet, R. Bekka, E. Vicaut, F. Lapostolle, V. Giraudeaux, C. Bismuth, F. Baud, S. P. Young, M. A. Haj, L. A. Robbie, G. Adey, A. M. Croll, N. A. Booth, B. Bennett, J. A. Santos, E. Ormaechea, M. Barcons, E. Quintana, G. Rialp, E. Bak, C. Puzo, P. Coll, A. Net, M. Blazková, P. Ŝteparová, H. Nejdlová, L. Jelínková, H. Winkelhoferová, R. Rokyta, M. Matejovic, V. Ŝrámck, I. Novák, L. Blinzler, K. Franz-Kilian, N. Benda, D. Heuser, F. Alvarez Lerma, D. Maladorno, H. Hager, B. Richelo, S. Teller, C. Berkowicz, D. O’Brien, A. Leighton, A. Dougnac, G. Hernandez, D. Angus, M. Ojeda, J. Castro, E. Labarca, L. Castillo, M. Andresen, G. Bugedo, O. Diaz, D. Arriagada, J. Dagnino
Journal: Intensive Care Medicine (1996)
Does 18-fluorodeoxyglucose (FDG) uptake by positron emission tomography/computed tomography (PET/CT) predict survival in advanced pancreatic cancer? A single-institution experience.
Authors: Noman Ashraf, Saqib Razzaque, Jill M. Weber, Mokenge Peter Malafa, Richard D. Kim
Journal: Journal of Clinical Oncology (2012)

351 Background: Pancreatic cancer is associated with a poor prognosis. Histological grade, stage and serum tumor markers are well established prognostic factors for survival. Some studies suggest that 18-fluorodeoxyglucose (FDG) uptake by positron emission tomography/computed tomography (PET/CT) correlates with survival in pancreatic cancer. In this study, we aimed to determine whether standardized uptake value (SUV), a measure of FDG uptake by fusion PET/CT, had prognostic significance in patients with advanced pancreatic cancer. Methods: Using a comprehensive pancreatic cancer database at H. Lee Moffitt Cancer Center, we identified patients who underwent PET/CT scan as initial workup for resection but were found to have advanced disease (stages III and IV) when surgery was attempted. Data from January 2006 to December 2010 was retrospectively analyzed and correlated with the maximum SUV determined by PET/CT. Other prognostic factors including stage, age, gender, serum tumor marker CA 19-9 levels and the use of chemotherapy were also evaluated using multivariate analysis. Results: We identified 41 consecutive patients who were deemed resectable by virtue of staging workup with CT, PET/CT and endoscopic ultrasound (EUS), but found to have locally advanced/metastatic disease intra-operatively. At the time of analysis, there were a total of 30 deaths. Twelve patients had metastatic disease and 29 had stage III pancreatic cancer. SUV uptake ranged from 2.9 to 16.2 with a mean of 6.4. Median overall survival for the 28 patients with SUV less than or equal to the mean (≤ 6.4) was 14 months (95% confidence interval 10 – 25 months) vs. 9.1 months for the 13 patients with SUV &gt; 6.4 (95% confidence interval 4-17 months). This difference was not statistically significant (p=0.178). On multivariate analysis, use of chemotherapy was the only independent predictor of survival. Conclusions: Glucose uptake by PET/CT, reflected by SUV, was not found to be a predictor of survival in patients with advanced pancreatic cancer. The retrospective nature and limited sample size are limitations of our study, however further research is warranted.
Multiple cell cycles occur in rat hepatocytes cultured in the presence of nicotinamide and epidermal growth factor
Authors: T Mitaka
Journal: Hepatology (1991)

Multiple rounds of cell division were induced in primary cultures of rat hepatocytes in serum-free medium containing 10 mmol/L nicotinamide and 10 ng epidermal growth factor/ml. Cells per culture almost doubled between day 1 and day 5. The proliferating cells were predominantly mononucleate. The time course of DNA synthesis in cultured hepatocytes showed that peaks of the incorporation of 3Hthymidine were observed at 60 hr and 82 hr after plating. Labeling indices of the cells indicated that almost half the cells were labeled with 3H-thymidine in the periods 48 to 72 hr and 72 to 96 hr after plating. In addition, about 20% of the hepatocytes in culture initiated a second round of the cell cycle between 48 and 96 hr in culture, as demonstrated by the use of continuous treatments with 3H-thymidine and 5-bromo-2′-deoxyuridine. Furthermore, by day 4 of culture, about 40% and 15% of metaphases resulted from a second and third round of cell division, respectively. The cultured hepatocytes on day 5 stained with albumin immunocytochemically, and the activity of tyrosine aminotransferase was induced by dexamethasone and glucagon on day 3. In addition, electron micrographs revealed that dividing cells not only had many characteristics of liver mitochondria and bile canaliculus-like structures, but many also contained a few large peroxisomes with internal crystalline nucleoids. (HEPATOLOGY 1991;13:21–30).
Cigarette advertising and corporate responsibility
Authors: S. Broder
Journal: JAMA (1992)

In the National Cancer Institute's first Smoking and Tobacco Control monograph released last October,<sup>1</sup>I stated my belief that the new generation of cartoon advertisements promoting Camel and Kool cigarettes would only serve to recruit millions of adolescents to the smoking ranks. With publication of the December 11, 1991, issue of<i>JAMA</i>, in which three independent studies reported a link between such advertisements and youth awareness and use of Camel cigarettes, this concern has proved justified. As an apparent result of the December 11 issue, RJR-Nabisco has gone on the offensive to discredit findings from these studies and, perhaps to confound their critics, has announced an antismoking campaign targeted to youth.<sup>2</sup>Ironically, the newly announced youth campaign also uses cartoons. According to the<i>Wall Street Journal</i>,<sup>3</sup>RJR-Nabisco defended their use of cartoons on the grounds that their own marketing tests revealed that children didn't relate as well
Sign of Double Apex Thrust
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antibodies to tumor growth factors herald new era in chemotherapy
Authors: B. Merz
Journal: JAMA (1988)

TWO CLINICAL TRIALS based on blocking tumor-cell growth factors represent an approach that may transform the face of cancer chemotherapy within the next decade. The phase I studies now under way at the National Cancer Institute, Bethesda, Md, and Memorial Sloan-Kettering Cancer Center, New York City, involve antibodies to growth factors and their receptors. Because these agents intercede in a particular process in a particular type of tumor cell, they have potentially greater specificity and fewer side effects than the tumoricidal agents currently in use. Thus they may make it much easier to spare the patient<i>and</i>spoil the tumor. The first of these agents—a monoclonal antibody to gastrin-releasing peptide (GRP)—has been in phase I clinical trials for 18 months. The antibody, manufactured by Hybritech in San Diego, is raised to bombesin, a regulatory peptide isolated from frog skin. Bombesin is the amphibian analogue of GRP, which stimulates human bronchial
Diseases of the Heart: Their Diagnosis, Prognosis, and Treatment by Modern Methods.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pain Control
Authors: Rudolph H. de Jong
Journal: JAMA (1977)

The June and July 1977 issues of our sister journal,Archives of Surgery, present a worthwhile and readable<i>Symposium on Pain</i>. Dr John Bonica, director of the University of Washington's renowned Pain Clinic, gathered ten authoritative papers that consider pain, particularly chronic pain, from several perspectives. Scientific foundations of the physiology, pathology, and psychology of pain show us how little still we really know about pain and how far we have to go yet. Articles cataloging progress in the management of chronic pain problems range from discussions of drugs and surgery to nerve blocks, acupuncture, electrical stimulation, and biofeedback. Throughout, the psychologic aspects of the patient suffering from long-standing pain are considered in a detached yet humane fashion. Though addressed to physicians in the surgical specialties, this symposium will have much to offer other readers; after all, pain is one of the most common symptoms that brings the patient to
Left bronchial isomerism, normal atrial arrangement and bronchomalacia mimicking asthma: a new syndrome?
Authors: A Bush
Journal: European Respiratory Journal (1999)

Three children who presented with steroid-resistant airflow obstruction are described. They all had bronchomalacia in the setting of a rare visceral arrangement, namely left bronchial isomerism with normal atrial arrangement. Imaging and, in two cases, a normal residual volume in the face of severe airflow obstruction were diagnostic pointers to a nonasthmatic cause of wheeze. Although the association of these abnormalities may be coincidental, together they may constitute a new clinical syndrome.