tbuckley/cabot-search huggingface dataset:
Erratum
Authors: Matthias Möhner, Michal Kulich, Vladimír ˇer ˇicha, Robert ˇer ˇicha, David Shore, Dale Sandler, Jens Bonde, Kiros Berhane, Rebecca Sokol, Roberto Ronchetti, Howard Hu, Martha María Téllez-Rojo, Héctor Lamadrid-Figueroa, Adriana Mercado-García, Mauricio Hernández-Avila, David Bellinger, Donald Smith, Adrienne Ettinger, Joel Schwartz, Lourdes Schnaas
Journal: Environmental Health Perspectives (2007)

Risk of Lymphohematopoietic Malignancies in Uranium MinersR ˇer ˇicha et al. (2006) analyzed data from Czech uranium miners with respect to incidence of malignancies of the lymphohematopoietic system.Their results, however, do not correspond with those of two recent studies on German uranium miners (Kreuzer et al. 2004; Möhner et al. 2006).R ˇer ˇicha et al. ( 2006) used a casecohort design, in which the subcohort was stratified by attained age and duration of employment.Stratification by age is a standard approach in case-cohort studies to optimize data ascertainment in the subcohort.However, stratification by duration of employment is problematic, because in occupational epidemiology it should be assumed that the duration of employment is highly correlated with cumulative exposure.Therefore, this kind of stratification contradicts the general demand for a random selection of controls with respect to exposure under study.Comparing the ratios of sampling fractions (< 12 months vs. ≥ 12 months duration of employment) between age groups results in a heterogeneous picture (Table 1).It is not uncommon in occupational cohort studies to include only subjects with a duration of employment of at least a certain number of months into the cohort.An analysis of only those miners with an employment duration of at least 12 months would be in line not only with the standard methodology but also with earlier published results of the authors (R ˇer ˇicha et al. 1998).Hence, the authors should have at least explained their reasoning for including the remaining miners in a second set of strata.In addition, they should have presented separate results for both duration strata to validate the result of the combined analysis.Given the above-mentioned assumption concerning the relationship between duration of employment and cumulative exposure, I calculated crude incidence rate ratios using data from Table 1 of R ˇer ˇicha et al. (2006).The age-specific odds ratios cover a wide range (0.29-7.16), and a corresponding test yields only borderline homogeneity.Consequently, completeness of matching with the cancer registry needs to be discussed.According to the study design, the time period between last exposure and begin of follow-up can span up to 27 years; therefore, the healthy-worker survivor effect could be an important issue in this study (R ˇer ˇicha et al. 2006).In light of the discussion on the magnitude of the latency period for leukemia, more detailed results would be useful to get an impression on, for example, the effect of the year of last exposure.
Abstracts
Journal: Annals of the Rheumatic Diseases (1967)

This preliminary but carefully conducted and controlled study from Emory University, Georgia, found little difference between 21 rheumatic fever subjects on sulfa- diazine prophylaxis and a similar number of matched controls in respect of the oral flora (alpha streotococci, coagulase-positive staphylococci, Neisseria, yeast, lacto- bacilli, fusiform bacilli, and spirilla) after 6 months, except for a significantly increased number of alpha streptococci in the prophylactic group.Antibiotic sensitivity was not studied but is to be investigated.
The Search and Destroy Strategy Prevents Spread and Long-term Carriage of MRSA; Results from Follow-up Screening of a Large ST22 (E-MRSA 15) Outbreak in Denmark
Authors: S. BÃ¶cher, R.L. Skov, M.A. Knudsen, L. Guardabassi, K. MÃ¸lbak, P. Schouenborg, M. SÃ¸rum, H. Westh
Journal: Clinical Microbiology and Infection (2009)
SPECIAL NOTICES.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulse pressure and risk of cardiovascular events among persons with isolated systolic hypertension Viola Vaccarino, Alan K. Berger, Jerome Abramson, Henry R. Black, John F. Setaro, Janice A. Davey, Harlan M. Krumholz. Yale University School of Medicine, New Haven, CT, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL
Journal: Journal of the American College of Cardiology (2001)
Results of a phase I trial of BAY 43–9006 in combination with doxorubicin in patients with refractory solid tumors
Authors: H. Richly, P. Kupsch, K. Passarge, M. Grubert, R. A. Hilger, C. G. Haase, B. Schwartz, M. E. Scheulen, S. Seeber, D. Strumberg
Journal: Journal of Clinical Oncology (2004)

3049
Treatment of Fractures and Dislocations, 1950–1960
Authors: Henry Banks, Thomas B. Quigley
Journal: New England Journal of Medicine (1960)

Dislocations and Fracture Dislocations of the HipThese severe injuries have been occurring more often in recent years.140 , 141 Posterior dislocations are still more common than those anterior or obturator in position. The treatment of uncomplicated dislocations has changed little, but all should be aware of the importance of very early reduction and the danger of avascular necrosis from delayed reduction and vigorous manipulation. A dislocated hip is a surgical emergency and must be reduced as swiftly and gently as the medical status of the patient will permit. Open reduction is much to be preferred to rough, repeated manipulation.Dislocations of . . .
That Was The Week That Was
Authors: J. R. E.
Journal: Annals of Internal Medicine (1968)

Editorials1 May 1968That Was The Week That WasJ. R. E.J. R. E.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1128 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe first week in April 1968 has passed into history, and along with it the first joint meeting of the American College of Physicians and the Royal College of Physicians of London. Perhaps it is not totally inappropriate to recall this week under the title of a now defunct program of political satire—for if ever there was a week thatwasin the political sense, it was that week. Even as the first joint function of the two Colleges was taking place on Sunday evening—the "family" dinner for the ACP officials, their ladies, and their British guests—the President of the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1128-1130 Issue Published: 1 May 1968 PDF DownloadLoading ...
The Homeless Mentally III
Authors: H. Richard Lamb
Journal: JAMA (1986)

The homeless mentally ill have become one of the greatest problems of present-day society. The American Psychiatric Association's Task Force on the Homeless Mentally III concluded that this is not the result of deinstitutionalization per se but of the way it has been carried out; homelessness among the chronically and severely mentally ill is symptomatic of the grave problems facing them generally in this country. Thus, the problem will not be solved until the basic underlying problems are addressed and a comprehensive and integrated system of care for the chronically mentally ill is established. Specific recommendations of the Task Force include an ample range of graded, supervised community housing; comprehensive and accessible psychiatric care and rehabilitation; the availability of general medical assessment and care, crisis services, and a dependable source of income; a system of case management in which one mental health worker is responsible for each patient; changes in commitment laws to make them more responsive to clinical needs; coordination between the various community resources; and ongoing asylum and sanctuary for that small proportion who require it. (<i>JAMA</i>1986;256:498-501)
Treatment of Strokes
Authors: Thomas R. Browne, David C. Poskanzer
Journal: New England Journal of Medicine (1969)

Cerebral EmbolismThe frequency of cerebral embolism is probably much greater than that cited in the literature. There is an increasing awareness of the frequency of embolic infarction as a cause of stroke, as measured on neuropathological examination by the presence of hemorrhagic infarction, and by the temporal course of the stroke without premonitory warning. Embolic strokes are said to account for approximately 3 to 8 per cent of the total of cerebrovascular accidents.Eighty per cent of recognized cerebral emboli are associated with mitral stenosis, myocardial infarction and atrial fibrillation.85 Twenty per cent of patients with complications of untreated . . .
Cardiovascular Disease and Death in Older Adults with Small Aneurysm in the Abdominal Aorta
Journal: Annals of Internal Medicine (2001)

Summaries for Patients6 February 2001Cardiovascular Disease and Death in Older Adults with Small Aneurysm in the Abdominal AortaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-3-200102060-00004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?The aorta, a large artery in the chest and the abdomen, is the main channel for carrying blood from the heart to the rest of the body. Abdominal aortic aneurysms are bulges that occur in weakened sections of the abdominal aorta. Aneurysms are more common in people with high blood pressure. Large aneurysms can burst, which often causes death. For this reason, it is generally recommended that patients with abdominal aortic aneurysms larger than about 2 inches across (5 cm) undergo an operation to replace the weakened section ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Cardiovascular Disease and Mortality in Older Adults with Small Abdominal Aortic Aneurysms Detected by Ultrasonography: The Cardiovascular Health Study.” It is in the 6 February 2001 issue of Annals of Internal Medicine (volume 134, pages 182-190). The authors are AB Newman, AM Arnold, GL Burke, DH O'Leary, and TA Manolio.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCardiovascular Disease and Mortality in Older Adults with Small Abdominal Aortic Aneurysms Detected by Ultrasonography: The Cardiovascular Health Study Anne B. Newman , Alice M. Arnold , Gregory L. Burke , Daniel H. O'Leary , and Teri A. Manolio Metrics 6 February 2001Volume 134, Issue 3Page: I-75KeywordsAbdominal aortic aneurysmAneurysmsAortaCardiovascular disease riskCardiovascular diseasesMedical risk factorsMyocardial infarctionPrimary hypertensionSurgeryUltrasound imaging ePublished: 6 February 2001 Issue Published: 6 February 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Book Reviews
Authors: Laura Michelacci, Giovanni A. Fava, Silvana Grandi, Luciano Bovicelli, Camillo Orlandi, Giancarlo Trombini, K. Engel, B. Wilfarth, Manuel Valdés, Josep Treserra, Lluisa Garcıa, Joan de Pablo, Tomás de Flores, Akira Ikemi, Sayuri Tomita, Yoshiaki Hayashida, Michael Bagby, Graeme J. Taylor, James D.A. Parker, Geir Nielsen, Karin Barth, Brit Haver, Odd E. Havik, Ester Mølstad, Henrik Rogge, Marit Skåtun, Jean Bovet, Edmond Gilliéron, Jacques Spagnoli, Denise Meylan
Journal: Psychotherapy and Psychosomatics (1988)
Small-bowel endoscopy
Authors: M. Pennazio
Journal: Endoscopy (2008)

Small-bowel endoscopy remains a particularly attractive subject for clinical research and debate. A total of 111 scientific contributions on this topic were presented at this year’s Digestive Diseases Week, 58 of which concerned capsule endoscopy and 53 flexible enteroscopy, the latter mainly balloon-assisted. Alongside various reports concerning technical aspects, new methods of enteroscopy and the clinical application of new capsules were also described.
Abstract 3800: HDAC8 regulates plasticity and escape from therapy in BRAF mutant melanoma
Authors: Michael Emmons, Fernanda Flores, John Koomen, Edward Seto, Jane Messina, Eric Lau, Jonathan Licht, Keiran Smalley
Journal: Cancer Research (2019)

Abstract Melanoma cells are highly plastic and have the ability to switch to a dedifferentiated, invasive phenotype in response to multiple stimuli. We here show that exposure to melanoma cell lines and patient specimens to multiple stresses including BRAF-MEK inhibitor therapy, hypoxia and UV-irradiation leads to an increase in HDAC8 expression/activity, and in turn, the adoption of a drug-resistant, invasive phenotype. Systems level analyses using mass spectrometry-based phosphoproteomics and RNA-Seq demonstrated HDAC8 to be involved in pathways that regulated cell cycle entry, ribosome function, RNA binding, regulation of the cytoskeleton and MAPK pathway signaling. Introduction of HDAC8 into drug-naïve melanoma cells conveyed resistance in vitro and in in vivo xenograft models. The HDAC8-mediated BRAF inhibitor resistance was mediated through upstream receptor tyrosine kinase (RTK) activation, Ras/CRAF/MEK/ERK signaling and the suppression of apoptosis through increased stabilization of Mcl-1 and the inhibition of pro-apoptotic BIM. Among the multiple RTKs increased by HDAC8, EGFR emerged as a direct transcriptional target, and it was found that EGFR inhibition could overcome HDAC8-mediated tolerance to BRAF inhibition. Although it is known that HDACs primarily function at the histone level, they can also regulate signaling through the modulation of cytoplasmic protein acteylation. In line with this, we observed that HDAC8 introduction decreased the acetylation of c-JUN, leading to an increase in its transcriptional activity and the enrichment for an AP-1 gene signature. Mutation of putative acetylation sites in c-JUN (K268R, K271R, K273R) reduced the transcriptional activation of c-JUN in melanoma cells and conveyed resistance to BRAF inhibition through increased MAPK pathway activity. In vivo xenograft studies confirmed the key role of HDAC8 in therapeutic adaptation, with either a pan-HDAC inhibitor (panobinostat) or an HDAC8 inhibitor (PCI-34051) enhancing the durability of response to BRAF inhibitor therapy. We have thus identified HDAC8 as a key driver of phenotype switching in melanoma that regulates the responses to multiple cellular stresses and conveys resistance to BRAF inhibition. Our studies demonstrate that isoform-specific HDAC8 inhibitors could be an excellent strategy to limit the adaptation of melanoma cells to multiple stresses and therapeutic interventions, including the BRAF-MEK inhibitor combination. Citation Format: Michael Emmons, Fernanda Flores, John Koomen, Edward Seto, Jane Messina, Eric Lau, Jonathan Licht, Keiran Smalley. HDAC8 regulates plasticity and escape from therapy in BRAF mutant melanoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3800.
Iatrogenic collapse.
Journal: BMJ (1979)

Certain trends are noticeable.Induction for purely social or medical convenience is recognised to be bad practice and is probably less used now than it was five years ago.Obstetricians are more aware of the need to pay careful attention to the gestational age and so avoid the embarrassment and the dangers of an unexpected premature delivery.Interest is passing increasingly to non-invasive techniques, which are more comfortable for the patients and less likely to bring complications.Finally, there is no agreement about an acceptable rate of induction, but McNay et al 8 are very likely right when they suggest that the optimum induction rate will vary from area to area depending on local medical and obstetric problems.
The Early Pattern of Conjugated Dienes in Liver and Lung after Endotoxin Exposure
Authors: Neil C. Clements, Michael P. Habib
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

If lipid peroxidation (LP) contributes to organ dysfunction in sepsis rather than simply reflecting established injury, it should occur soon after the onset of the septic insult, and it may not progress uniformly in all organs. We assessed whether LP occurs within 90 min after onset of continuous intravenous endotoxin (E. coli 055:B5) infusion in rats, using second-derivative spectroscopy to semiquantitatively assess conjugated dienes (CD) in lung, liver, and plasma phospholipids. Measurements were also made after 90-min infusions with saline or 1 mM H2O2. Both the quantity and spectrophotometric patterns of CD differed between the three groups. Compared with saline controls, lung lipid CD increased after both H2O2 and endotoxin. Venous plasma CD were elevated only after H2O2, while arterial plasma and liver lipid CD were not different between the three groups. Exhaled ethane (an indicator of peroxidation of omega-3 fatty acids) did not differ between groups. Wet-to-dry lung weights were significantly increased after endotoxin compared with that after saline controls. Our results indicate that tissue-specific LP occurs within 90 min of endotoxin or H2O2 intravenous infusion.
NETHERLANDS
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neurodevelopment After In Utero Exposure to Phenytoin and Carbamazepine
Authors: Joseph S. Jeret
Journal: JAMA (1994)

<h3>To the Editor.</h3> —The study by Dr Scolnik and colleagues<sup>1</sup>has two important flaws. The authors acknowledge that "even when not exposed to medications, infants of mothers with epilepsy have higher rates of malformations than those in the general population." They then compare 36 patients taking carbamazepine, of whom only 30 (83%) were epileptic, with 34 patients taking phenytoin, of whom 33 (97%) were epileptic (χ<sup>2</sup>=3.7, P=.05). The epileptics receiving phenytoin are inherently more likely to bear malformed children. In addition, the mean maternal dose of phenytoin was 5.9 mg/kg per day and for carbamazepine 8.9 mg/kg per day. For a 60-kg woman, that translates to a daily dose of 354 mg of phenytoin and 534 mg of carbamazepine. The<i>Physicians' Desk Reference</i><sup>2</sup>lists the average adult maintenance doses for phenytoin as 300 to 400 mg per day and for carbamazepine as 800 to 1200 mg
Hib Vaccine Efficacy Trials Continue; Data Needed About Use in Younger Children
Authors: Charles Marwick
Journal: JAMA (1989)

PREVENTING<i>Haemophilus influenzae</i>type b by vaccination in the very young is going to have to wait a bit. Although several new conjugate vaccines have been licensed for use in children 18 months of age and older (<i>JAMA</i>. 1989;261:1152-1153), it appears that additional data from ongoing trials will be needed before these and similar vaccines can be licensed for use in children younger than 18 months. Several trials are in progress in the United States among infant populations to study the efficacy of newer, more potent versions of<i>H influenzae</i>vaccines that may be successful in protecting children as young as 2 months of age. Children less than 18 months old appear to be the most susceptible to this disease, with about two thirds of cases occurring in this age group. An estimated 20 000 cases of<i>H influenzae</i>occur in the United States each year, with 12 000 cases
Selected New Books
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal