tbuckley/cabot-search huggingface dataset:
A Rare Cause of Quincke's Triad
Authors: Elia Armellini, Francesca Besana, Flavio Metelli
Journal: Clinical Gastroenterology and Hepatology (2023)

A 48-year-old patient was referred for anemia, jaundice, and right upper-quadrant pain, 5 months after a thorough evaluation for anemia resulting from obscure gastrointestinal bleeding. Abdominal imaging at admission showed a mass in the gallbladder, and endoscopic ultrasound confirmed the presence of a polyp-like lesion with a vascular stalk and clots within the gallbladder. During endoscopic ultrasound, hemobilia was visible (Figures A, B, and C, and Video 1). Laparoscopic cholecystectomy was performed with resolution of symptoms and the final diagnosis was gallbladder melanoma (Figure D). The patient had no history of melanoma and a search for an alternative primary site was unrevealing. Adjuvant treatment with nivolumab was initiated. Primary gallbladder and biliary tract melanoma is extremely rare, with only 37 and 14 cases reported in the literature, respectively. Most cases are caused by metastatic disease. No record of melanoma, the presence of a solitary lesion with a polypoid shape, and histologic examination showing junctional activity all indicate a primary tumor. Gallbladder melanoma most commonly is asymptomatic, but symptoms may occur including abdominal pain, nausea and vomiting, anemia, hemobilia, obstructive jaundice, and acute cholecystitis. Hemobilia associated with jaundice and right upper-quadrant pain, known as Quincke's triad, is an uncommon clinical manifestation, with only a handful of reported cases. eyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiJmMTA0YmQ4ZDFmZTA1MjcyZDMwYmU2MDliZmEyMTg1NyIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNzAzMjY4NDA1fQ.bbrGxCioHz6UNzPkj229dcAXqLsQIkFRxyvqdVFR2jJDTI6QL0WHBuvlzkfM_WRaOcSUk9poyg7uT-Z91i9uFnCAxl5jqW13-1_5YWJhRcixAW3kiGVtsAf4DMZi-DHBqD1NH6dP6f1GP6CT7FV2hPGLkyDDsn5Js8GoZSQ_7ddjyBcLmSShcC2xIeFdn1wwPdL7SRGIDNObG6gosCWm2o12Dbos0eMJYjZtXL9voAQGrDytya-D4EwD4UsyP4h3QNUc6U7uP4rGR_k0Vdc9QlRVxgrTk0r8tQYuirs4o8lDNkUB0DNbJEAtdfU7TbZ1651TzDoes72uI6GZMV-H1A Download .mp4 (19.58 MB) Help with .mp4 files Video
Potent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode
Authors: Xiaolin Wen, Naveenchandra Suryadevara, Nurgun Kose, Jing Liu, Xiaoyan Zhan, Laura S. Handal, Lauren E. Williamson, Andrew Trivette, Robert H. Carnahan, Theodore S. Jardetzky, James E. Crowe
Journal: Cell Host & Microbe (2023)
Ketolysis drives CD8+ T cell effector function through effects on histone acetylation
Authors: Katarzyna M. Luda, Joseph Longo, Susan M. Kitchen-Goosen, Lauren R. Duimstra, Eric H. Ma, McLane J. Watson, Brandon M. Oswald, Zhen Fu, Zachary Madaj, Ariana Kupai, Bradley M. Dickson, Lisa M. DeCamp, Michael S. Dahabieh, Shelby E. Compton, Robert Teis, Irem Kaymak, Kin H. Lau, Daniel P. Kelly, Patrycja Puchalska, Kelsey S. Williams, Connie M. Krawczyk, Dominique Lévesque, François-Michel Boisvert, Ryan D. Sheldon, Scott B. Rothbart, Peter A. Crawford, Russell G. Jones
Journal: Immunity (2023)

Environmental nutrient availability influences T cell metabolism, impacting T cell function and shaping immune outcomes. Here, we identified ketone bodies (KBs)-including β-hydroxybutyrate (βOHB) and acetoacetate (AcAc)-as essential fuels supporting CD8
Play and tickling responses map to the lateral columns of the rat periaqueductal gray
Authors: Natalie Gloveli, Jean Simonnet, Wei Tang, Miguel Concha-Miranda, Eduard Maier, Anton Dvorzhak, Dietmar Schmitz, Michael Brecht
Journal: Neuron (2023)

The persistence of play after decortication points to a subcortical mechanism of play control. We found that global blockade of the rat periaqueductal gray with either muscimol or lidocaine interfered with ticklishness and play. We recorded vocalizations and neural activity from the periaqueductal gray of young, playful rats during interspecific touch, play, and tickling. Rats vocalized weakly to touch and more strongly to play and tickling. Periaqueductal gray units showed diverse but strong modulation to tickling and play. Hierarchical clustering based on neuronal responses to play and tickling revealed functional clusters mapping to different periaqueductal gray columns. Specifically, we observed play-neutral/tickling-inhibited and tickling/play-neutral units in dorsolateral and dorsomedial periaqueductal gray columns. In contrast, strongly play/tickling-excited units mapped to the lateral columns and were suppressed by anxiogenic conditions. Optogenetic inactivation of lateral periaqueductal columns disrupted ticklishness and play. We conclude that the lateral periaqueductal gray columns are decisive for play and laughter.
The microbiome of the neovagina: a systematic review and comparison of surgical techniques
Authors: Jenna R. Stoehr, Civanni Moss, Hamidian Jahromi A
Journal: International Journal of Transgender Health (2023)

: Vaginoplasty is performed to create a neovagina for transgender individuals who seek surgical transition or for cisgender individuals with congenital or acquired absence of a vagina (or "cisvagina"). The current knowledge of the bacterial microenvironment of the neovagina is limited. The objective of this study was to conduct a systematic review of current knowledge regarding the microbiome of the neovagina in transgender women.
A contemporary review of clade-specific virological differences in monkeypox viruses
Authors: Tochi Okwor, Placide K. Mbala, David H. Evans, Jason Kindrachuk
Journal: Clinical Microbiology and Infection (2023)

Monkeypox virus (MPXV) is an emerging zoonotic virus that has had on-going public health impacts in endemic regions of Central and West Africa for over a half-century. Historically, the MPXV clade endemic in regions of Central Africa is associated with higher morbidity and mortality as compared with the clade endemic in West Africa.Here, we review the virological characteristics of MPXV and discuss potential relationships between virulence factors and clade- (and subclade-) specific differences in virulence and transmission patterns.Targeted search was conducted in PubMed using ((monkeypox virus) OR (Orthopoxvirus)) AND (zoonosis)) OR ((monkeypox) OR (human mpox).Forty-seven references were considered that included three publicly available data reports and/or press releases, one book chapter, and 44 published manuscripts.Although zoonosis has been historically linked to emergence events in humans, epidemiological analyses of more recent outbreaks have identified increasing frequencies of human-to-human transmission. Furthermore, viral transmission during the 2022 global human mpox outbreak, caused by a recently identified MPXV subclade, has relied exclusively on human-to-human contact with no known zoonotic link.
Challenges and opportunities for incentivising antibiotic research and development in Europe
Authors: Michael Anderson, Dimitra Panteli, Robin van Kessel, Gunnar Ljungqvist, Francesca Colombo, Elias Mossialos
Journal: The Lancet Regional Health - Europe (2023)

Antimicrobial, and particularly antibiotic resistance are one of the world's biggest challenges today, and urgent action is needed to reinvigorate the antibiotic development pipeline. To inform policy discussions during and after the 2023 Swedish Presidency of the Council of the European Union, we critically appraise incentive options recently proposed by the European Commission, and member states, and consider what has been achieved over the last two decades in relation to antibiotic research and development. While several new antibiotics have achieved regulatory approval in recent years, almost none have innovative characteristics such as new chemical classes or novel mechanisms of action. We consider four incentive options to incentivise research and development of new antibiotics, including subscription payments, market entry rewards, transferable exclusivity extensions, and milestone payments. While each option has advantages and drawbacks, a combination of incentives may be required and continued investment is needed by the EU in push incentives, such as direct funding and grants, to incentivise drug discovery and preclinical stages of development. The EU must also coordinate with international initiatives and support access to new and pre-existing antibiotics in LMICs through platforms such as the WHO, and G7 and G20 group of countries.
Thermophobic Trehalose Glycopolymers as Smart C‐Type Lectin Receptor Vaccine Adjuvants (Adv. Healthcare Mater. 19/2023)
Authors: Aaron T. Hendricksen, Shahrzad Ezzatpour, Anunay J. Pulukuri, Austin T. Ryan, Tatum J. Flanagan, William Frantz, David W. Buchholz, Victoria Ortega, Isaac A. Monreal, Julie M. Sahler, Amy E. Nielsen, Hector C. Aguilar, Rock J. Mancini
Journal: Advanced Healthcare Materials (2023)

Thermoresponsive Polymers Adjuvant additives enhance the efficacy of many vaccines, however, their use must be judiciously tailored because adjuvants also cause inflammatory side effects such as pyrexia. In article 2202918, Rock J. Mancini and co-workers create thermophobic vaccine adjuvants that attenuate activity at increased temperatures correlating to that experienced during mild pyrexia. These thermophobic adjuvants remain effective in vivo where they improve the efficacy of a model Influenza vaccine resulting in enhanced neutralizing antibodies and memory T-cells as well as reduced morbidity upon viral re-challenge. Overall, this technology presents a new way to create adjuvants that enhance vaccine efficacy while simultaneously limiting inflammatory side effects.
Human anti-N1 monoclonal antibodies elicited by pandemic H1N1 virus infection broadly inhibit HxN1 viruses in vitro and in vivo
Authors: Lena Hansen, Meagan McMahon, Hannah L. Turner, Xueyong Zhu, Jackson S. Turner, Gabriel Ozorowski, Daniel Stadlbauer, Juha Vahokoski, Aaron J. Schmitz, Amena A. Rizk, Wafaa B. Alsoussi, Shirin Strohmeier, Wenli Yu, José Alberto Choreño-Parra, Luis Jiménez-Alvarez, Alfredo Cruz-Lagunas, Joaquín Zúñiga, Philip A. Mudd, Rebecca J. Cox, Ian A. Wilson, Andrew B. Ward, Ali H. Ellebedy, Florian Krammer
Journal: Immunity (2023)
Bioprinting of Stem Cell Spheroids Followed by Post‐Printing Chondrogenic Differentiation for Cartilage Tissue Engineering (Adv. Healthcare Mater. 19/2023)
Authors: Monize Caiado Decarli, Adrián Seijas‐Gamardo, Francis L. C. Morgan, Paul Wieringa, Matthew B. Baker, Jorge Vicente L. Silva, Ângela Maria Moraes, Lorenzo Moroni, Carlos Mota
Journal: Advanced Healthcare Materials (2023)

Bioprinting In article 2203021 by Carlos Mota and co-workers, a polysaccharide-based hydrogel and human mesenchymal stromal cell spheroids are combined to obtain a bioink. Using the spheroid-based bioink, contructs were bioprinted and successfully differentiated post-bioprinting to obtain cartilagelike tissues.
Electrical Stimulation Promotes the Vascularization and Functionalization of an Engineered Biomimetic Human Cardiac Tissue (Adv. Healthcare Mater. 19/2023)
Authors: Bingchuan Lu, Min Ye, Jingjing Xia, Zhenrui Zhang, Zhuo Xiong, Ting Zhang
Journal: Advanced Healthcare Materials (2023)

Biomimetic Cardiac Tissue The formation of multiscale vascular networks is essential for the in vitro construction of largescale biomimetic cardiac tissues/organs. In article 2300607, Zhuo Xiong, Ting Zhang, and co-workers demonstrate that electrical stimulation promotes vascularization and cardiomyocytes functionalization in engineered cardiac tissue (ECT), which has important application potential in the fabrication of vascularized ECTs and its clinical transplantation. Thus, this cover displays an electrical field generated by a pair of parallel electrodes. In the electrical field are symmetrically lined myocardium fibers that interweave with blood vessels. The formation of multi-scale blood vessels and higher maturity in the biofabricated cardiac tissue/organs is hoped to be accomplished.
Single-cell profiling of prurigo nodularis demonstrates immune-stromal crosstalk driving profibrotic responses and reversal with nemolizumab
Authors: Feiyang Ma, Mehrnaz Gharaee-Kermani, Lam C. Tsoi, Olesya Plazyo, Prasad Chaskar, Paul Harms, Matthew T. Patrick, Xianying Xing, Grace Hile, Christophe Piketty, Anne Lazzari, Wouter Van Delm, Emanual Maverakis, Mio Nakamura, Robert L. Modlin, J. Michelle Kahlenberg, Allison C. Billi, Valerie Julia, Jayendra Kumar Krishnaswamy, Johann E. Gudjonsson
Journal: Journal of Allergy and Clinical Immunology (2023)

Prurigo nodularis (PN) is a chronic neuroimmune skin disease characterized by bilaterally distributed pruritic hyperkeratotic nodules on extremities and trunk. Neuroimmune dysregulation and chronic scratching are believed to both induce and maintain the characteristic lesions.
In‐Depth Occlusion of Dentinal Tubules and Rapid Remineralization of Demineralized Dentin Induced by Polyelectrolyte‐Calcium Complexes (Adv. Healthcare Mater. 19/2023)
Authors: Zihuai Zhou, Jiachen Li, Zhe Wang, Hongli Zhang, Yiru Wang, Dongni Shen, Zhifang Wu, Minjuan Shen, Haihua Pan, Qi Wang, Ruikang Tang, Matthias Hannig, Baiping Fu
Journal: Advanced Healthcare Materials (2023)

Dentin Hypersensitivity In article 2300100, Baiping Fu and co-workers propose an innovative mineralizing desensitizer based on the polyelectrolyte-calcium complexes pre-precursor (PCCP) process. After a brief application, PCCP mineralizing desensitizer achieves in-depth occlusion of exposed dentinal tubules over 200 µm and rapid remineralization of demineralized dentin matrix via a pH-dependent electrostatic attraction. It might shed light on a promising dentin desensitizing strategy for dentin hypersensitivity management.
Does Urologist-level Utilization of Active Surveillance for Low-risk Prostate Cancer Correspond with Utilization of Active Surveillance for Small Renal Masses?
Authors: Michael Wang, Sophie Wittenberg, Michael L. Cher, Monica Van Til, Stephanie Ferrante, Mahin Mirza, Anna Johnson, Alice Semerjian, Arvin George, Craig Rogers, Samantha Wilder, Richard Sarle, Khurshid R. Ghani, Brian Lane, Kevin B. Ginsburg
Journal: European Urology (2023)
The global effect of digital health technologies on health workers’ competencies and health workplace: an umbrella review of systematic reviews and lexical-based and sentence-based meta-analysis
Authors: Israel Júnior Borges do Nascimento, Hebatullah Mohamed Abdulazeem, Lenny Thinagaran Vasanthan, Edson Zangiacomi Martinez, Miriane Lucindo Zucoloto, Lasse Østengaard, Natasha Azzopardi-Muscat, Tomas Zapata, David Novillo-Ortiz
Journal: The Lancet Digital Health (2023)

Systematic reviews have quantified the effectiveness, feasibility, acceptability, and cost-effectiveness of digital health technologies (DHTs) used by health-care workers. We aimed to collate available evidence on technologies' effect on health-care workers' competencies and performance. We searched the Cochrane Database of Systematic Reviews, Embase, MEDLINE, Epistemonikos, and Scopus for reviews published from database inception to March 1, 2023. Studies assessing the effects of DHTs on the organisational, socioeconomic, clinical, and epidemiological levels within the workplace, and on health-care workers' performance parameters, were included. Data were extracted and clustered into 25 domains using vote counting based on the direction of effect. The relative frequency of occurrence (RFO) of each domain was estimated using R software. AMSTAR-2 tool was used to appraise the quality of reporting, and the Confidence in the Evidence from Reviews of Qualitative research approach developed by Grading of Recommendations Assessment, Development and Evaluation was used to analyse the certainty of evidence among included studies. The 12 794 screened reviews generated 132 eligible records for assessment. Top-ranked RFO identifiers showed associations of DHT with the enhancement of health-care workers' performance (10·9% [95% CI 5·3–22·5]), improvement of clinical practice and management (9·8% [3·9–24·2]), and improvement of care delivery and access to care (9·2% [4·1–20·9]). Our overview found that DHTs positively influence the daily practice of health-care workers in various medical specialties. However, poor reporting in crucial domains is widely prevalent in reviews of DHT, hindering our findings' generalisability and interpretation. Likewise, most of the included reviews reported substantially more data from high-income countries. Improving the reporting of future studies and focusing on low-income and middle-income countries might elucidate and answer current knowledge gaps.
Ultrasound identification of hepatic echinococcosis using a deep convolutional neural network model in China: a retrospective, large-scale, multicentre, diagnostic accuracy study
Authors: Yongfeng Yang, Yangdan Cairang, Tian'an Jiang, Jianhua Zhou, Li Zhang, Baowen Qi, Shumei Ma, Lina Tang, Dong Xu, Lingdai Bu, Rui Bu, Xiang Jing, Hui Wang, Zubang Zhou, Cheng Zhao, Baoming Luo, Liwen Liu, Jianqin Guo, Yuzhen Nima, Guoyong Hua, Zengcheng Wa, Yuying Zhang, Guoyi Zhou, Wen Jiang, Changcheng Wang, Yang De, Xiaoling Yu, Zhigang Cheng, Zhiyu Han, Fangyi Liu, Jianping Dou, Hui Feng, Chong Wu, Ruifang Wang, Jie Hu, Qi Yang, Yanchun Luo, Jiapeng Wu, Haining Fan, Ping Liang, Jie Yu
Journal: The Lancet Digital Health (2023)
Yeast phagocytosis by eosinophils: a case of disseminated histoplasmosis diagnosed in a peripheral blood smear
Authors: Javier Camuña Correa, María Paniagua García, Concepción Prats-Martín, María José Gómez-Gómez, Rosario M Morales-Camacho, Jose Antonio Farah Gamarra, María J Buitrago, Eusebio Martín-Chacón
Journal: The Lancet Infectious Diseases (2023)
Dendritic cell type 3 arises from Ly6C+ monocyte-dendritic cell progenitors
Authors: Zhaoyuan Liu, Haiting Wang, Ziyi Li, Regine J. Dress, Yiwen Zhu, Shuangyan Zhang, Donatella De Feo, Wan Ting Kong, Peiliang Cai, Amanda Shin, Cécile Piot, Jiangyan Yu, Yaqi Gu, Mingnan Zhang, Caixia Gao, Lei Chen, Honglin Wang, Mathias Vétillard, Pierre Guermonprez, Immanuel Kwok, Lai Guan Ng, Svetoslav Chakarov, Andreas Schlitzer, Burkhard Becher, Charles-Antoine Dutertre, Bing Su, Florent Ginhoux
Journal: Immunity (2023)
Associations of Habitual Calcium Supplementation With Risk of Cardiovascular Disease and Mortality in Individuals With and Without Diabetes
Authors: Zixin Qiu, Qi Lu, Zhenzhen Wan, Tingting Geng, Rui Li, Kai Zhu, Lin Li, Xue Chen, An Pan, JoAnn E. Manson, Gang Liu
Journal: Diabetes Care (2023)

OBJECTIVE To prospectively examine the associations of habitual calcium supplementation with cardiovascular disease (CVD) events and mortality in individuals with and without diabetes. RESEARCH DESIGN AND METHODS The main analysis included 434,374 participants from the UK Biobank. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% CIs. Interactions of calcium supplement use with diabetes status were tested on multiplicative and additive scales. RESULTS Over a median follow-up of 8.1 and 11.2 years, 26,374 incident CVD events and 20,526 deaths were documented, respectively. After multivariable adjustment, habitual calcium supplementation was significantly associated with higher risks of CVD incidence (HR 1.34; 95% CI 1.14, 1.57), CVD mortality (HR 1.67; 95% CI 1.19, 2.33), and all-cause mortality (HR 1.44; 95% CI 1.20, 1.72) in participants with diabetes, whereas no significant association was observed in participants without diabetes (HR 0.97 [95% CI 0.92, 1.03] for CVD incidence; HR 1.05 [95% CI 0.90, 1.23] for CVD mortality; HR 1.02 [95% CI 0.96, 1.09] for all-cause mortality). Significant multiplicative and additive interactions were found between habitual calcium supplementation and diabetes status on risks of CVD events and mortality (all Pinteraction &amp;lt; 0.05). In contrast, no significant interactions were observed between dietary or serum calcium and diabetes status. CONCLUSIONS Habitual use of calcium supplements was significantly associated with higher risk of CVD events and mortality in people with diabetes but not in people without diabetes. Further studies are needed to balance potentially adverse effects of calcium supplement against likely benefits, particularly among patients with diabetes.
Incidence and outcomes of acute kidney injury including hepatorenal syndrome in hospitalized patients with cirrhosis in the US
Authors: Kavish R. Patidar, Justin M. Belcher, Kevin R. Regner, Shelsea A. St. Hillien, Douglas A. Simonetto, Sumeet K. Asrani, Javier A. Neyra, Pratima Sharma, Juan Carlos Q. Velez, Hani Wadei, Mitra K. Nadim, Raymond T. Chung, Ritu Seethapathy, Xavier Vela Parada, Tianqi Ouyang, Nneka N. Ufere, Jevon E. Robinson, Paige McLean Diaz, Robert M. Wilechansky, Eric M. Przybyszewski, Thomas N. Smith, Arzina Aziz Ali, Eric S. Orman, Philipp Schulz, Salaah M. Siddiqui, Rehma Shabbir, Lucas J. Liu, Augusto Cama-Olivares, Alexander H. Flannery, Megan L. Baker, Deepthi Gunasekaran, Adeline Aswine, Rafik Issa, Jay Li, Shreya Verma, Dustin Chalmers, Vipin Varghese, Walter Lam, Muner Mohamed, Rosemary Kovacic, Anna Gaddy, Rose Mary Attieh, Pedro Cortes, Sahar Semnani, Lin Wang, Saro Khemichian, Andrew S. Allegretti
Journal: Journal of Hepatology (2023)
Antibacterial conductive self-healing hydrogel wound dressing with dual dynamic bonds promotes infected wound healing
Authors: Lipeng Qiao, Yongping Liang, Jueying Chen, Ying Huang, Saeed A. Alsareii, Abdulrahman Manaa Alamri, Farid A. Harraz, Baolin Guo
Journal: Bioactive Materials (2023)

In clinical applications, there is a lack of wound dressings that combine efficient resistance to drug-resistant bacteria with good self-healing properties. In this study, a series of adhesive self-healing conductive antibacterial hydrogel dressings based on oxidized sodium alginate-grafted dopamine/carboxymethyl chitosan/Fe3+ (OSD/CMC/Fe hydrogel)/polydopamine-encapsulated poly(thiophene-3-acetic acid) (OSD/CMC/Fe/PA hydrogel) were prepared for the repair of infected wound. The Schiff base and Fe3+ coordination bonds of the hydrogel structure are dynamic bonds that can be repaired automatically after the hydrogel network is disrupted. Macroscopically, the hydrogel exhibits self-healing properties, allowing the hydrogel dressing to adapt to complex wound surfaces. The OSD/CMC/Fe/PA hydrogel showed good conductivity and photothermal antibacterial properties under near-infrared (NIR) light irradiation. In addition, the hydrogels exhibit tunable rheological properties, suitable mechanical properties, antioxidant properties, tissue adhesion properties and hemostatic properties. Furthermore, all hydrogel dressings improved wound healing in the infected full-thickness defect skin wound repair test in mice. The wound size repaired by OSD/CMC/Fe/PA3 hydrogel + NIR was much smaller (12%) than the control group treated with Tegaderm™ film after 14 days. In conclusion, the hydrogels have high antibacterial efficiency, suitable conductivity, great self-healing properties, good biocompatibility, hemostasis and antioxidant properties, making them promising candidates for wound healing dressings for the treatment of infected skin wounds.