tbuckley/cabot-search huggingface dataset:
Recommended Guidelines for Relationships Between Voluntary Health Agencies and Governmental Health Programs
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serum, breast milk, and infant antibody after maternal immunisation with pneumococcal vaccine
Authors: N.S Shahid, S.S Hoque, T Begum, M.C Steinhoff, C Thompson, G.R Siber
Journal: The Lancet (1995)

Serum, breast milk, and infant antibody after maternal immunisation with pneumococcal vaccine Summary Pneumococci are a leading cause of severe bacterial disease in infants and children world wide.A possible means of protecting infants in the first few months of life is immunisation of the mother during pregnancy.We prospectively assessed pneumococcal immunisation of pregnant women to determine the amount of pneumococcal antibody transmitted to the infants in serum and milk and the half-life of the passively acquired antibody.Healthy pregnant women in Dhaka, Bangladesh, were randomised to receive pneumococcal or meningococcal vaccine with routine prenatal tetanus immunisation at 30-34 weeks of gestation.Serum and breast milk specimens from the mothers and sera from infants were collected up to 22 weeks of age and assayed for specific serum IgG, IgG1, and IgG2 and for milk IgA antibodies to pneumococcal serotypes 6B and 19F. mothers and 56 infants were followed from birth to five months.Women who received pneumococcal vaccine had geometric mean antibody increases of 2&middot;6 and 3&middot;4 to types 6B and 19F, respectively.The mean infant/maternal antibody ratios were 0&middot;56 and 0&middot;59 (range 0&middot;11-1&middot;46) for these serotypes.Infant cord antibody titres correlated with maternal titres.Infant/maternal IgG ratios correlated with the interval between immunisation and birth and were higher for specific IgG1 than for IgG2.Infants of pneumococcal vaccine recipients had geometric mean antibody concentrations of 6&middot;8 and 7&middot;5 &micro;g/mL to serotypes 6B and 19F in cord blood; in cord blood and in all subsequent serum specimens the concentrations were 2-3 fold higher than in control infants.The median half-life of passive antibody was about 35 days; at five months of age 63-71% of infants of pneumococcal vaccine recipients had antibody concentrations greater than 0&middot;15 &micro;g/mL.Breast milk IgA antibodies for pneumococcal serotype 19F, but not for type 6B, were significantly higher in vaccine recipients up to five months after delivery.If maternal pneumococcal polysaccharide antibodies do not interfere with active immunisation of the infant with new glycoprotein conjugate pneumococcal vaccines, passive-active immunisation of infants can be a feasible strategy for developing regions.
Hospital admission through the emergency department. The obstructed pathway
Authors: C. M. Olson
Journal: JAMA (1991)

In this issue ofThe Journal, Stern et al<sup>1</sup>compare hospital charges and lengths of stay for patients admitted through the emergency department with charges and lengths of stay for patients admitted through other routes to any of five Massachusetts hospitals. Even with adjustments for diagnosis related group, severity of illness, age, and income, patients admitted through the emergency department incurred hospital charges 13% higher and hospital stays 27% longer than other patients.
Association of prostate-specific antigen (PSA) trajectories with risk for metastasis and mortality in non-metastatic castration-resistant prostate cancer (nmCRPC).
Authors: Sophia Li, Zhijie Ding, Jennifer H Lin, Ajay S. Behl, Chris Pericone, Brian Macomson, Neal D. Shore
Journal: Journal of Clinical Oncology (2018)

e17056 Background: Currently there is insufficient guidance for the management of nmCRPC. This study assessed patient risk of developing metastases and death based on their PSA levels over time. Methods: This was a retrospective study using the Optum electronic health record database (1/1/2007 – 4/30/2016) in men ≥18 years. nmCRPC was defined as a PC diagnosis, 2 rising PSA levels ≥1 week apart, testosterone < 50 ng/dL (post-PC diagnosis), and no ICD-9/10 code or therapy indicating metastasis. Patients were required to have ≥1 PSA record per 3-month period for 9 months following nmCRPC diagnosis. Group Based Trajectory Modeling (GBTM) was used to group patients based on similar PSA trends over 9 months. The association of these PSA groups with metastasis/mortality risk was measured using multivariate Cox proportional hazard regression models. An overall trend for metastasis and mortality across the groups was also tested. Results: From a total of 729 patients included, 4 distinct groups were identified: Group 1 (49% of patients), 2 (32%), 3 (14%) and 4 (5%). Group 1 had the lowest PSA (7 ng/mL) at nmCRPC diagnosis and steady PSA during the 9-month follow-up. In contrast, Groups 2, 3 and 4 had higher PSA at nmCRPC diagnosis (17, 61, 513 ng/mL respectively) and rising PSA during follow-up. There was a trend of increasing metastasis and mortality risk (p < 0.001 for both trends) with the higher PSA groups. For metastasis, Hazard Ratios (HRs) and 95% confidence intervals (CIs) were 1.7 (1.3-2.2), 3.5 (2.5-5.0), 1.8 (0.7-4.7) in Groups 2, 3 and 4, respectively, vs. Group 1. For mortality, HRs (95% CIs) were 1.9 (1.4-2.5), 2.6 (1.8-3.7), 4.5 (2.4-8.4) in Groups 2, 3 and 4, respectively, vs. Group 1. Metastasis-free survival (MFS) independently predicted mortality risk. Patients developing metastasis within 1 year had 4.4-fold greater risk for mortality (95% CI = 2.2-8.8) than those who remained MFS at year 3. Conclusions: A large proportion of nmCRPC patients with PSA increases during the follow-up period had significantly increased risk for metastasis and mortality, with MFS predicting mortality risk. Periodic measurement of PSA may better inform management of nmCRPC.
Anatomie des Menschen: Ein Lehrbuch für Studierende und Ärzte. Band II: Eingeweide (einschliesslich periphere Leitungsbahnen I.)
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bone Tumors
Authors: David C. Dahlin
Journal: JAMA (1972)

This book, as the previous editions, is clearly written and the illustrations are generally good. Clinical and radiologic correlations with pathologic observations are stressed throughout, as one would expect, since Jaffe and Lichtenstein, more than any others, pioneered in this all-important approach to the understanding of bone tumors. The author stresses the limitations of needle biopsy as a diagnostic tool. Some criticisms do not disparage the many good qualities of the book. The documentation of chondroblastic sarcoma is not clear enough to convince me that it is a recognizable entity. In the same chapter, atypical chondroblastomas and atypical chondromyxoid fibromas are described. Would it not be less confusing to have the discussions of these lesions in the chapters on chondroblastoma and chondromyxoid fibroma, respectively? Although the author is adamant about separating osteoid osteoma from the generally larger benign osteoblastomas, he illustrates two large or "giant" osteoid osteomas but does not
HEMATOGENOUS STAPHYLOCOCCUS INFECTIONS SECONDARY TO FOCI IN THE SKIN
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Denial in the Medical Interview
Authors: Eve J. Wiseman
Journal: JAMA (1995)

<h3>To the Editor.</h3> —I enjoyed the recent<i>JAMA</i>article entitled "Denial in the Medical Interview."<sup>1</sup>Although recognizing the potential impact of denial, the authors did not discuss how the process of denial has been incorporated into psychiatric and medical nosology. Denial was included as a critical component of the definition and criteria for the diagnosis of alcoholism formulated by the Joint Committee of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine.<sup>2</sup> The American Psychiatric Association, however, did not rely on the concept of denial in developing diagnostic criteria for alcohol dependence. Rounsaville et al<sup>3</sup>recognized that individuals who denied alcohol use would fail to meet criteria from the<i>Diagnostic and Statistical Manual (DSM)</i>,<sup>4</sup>but proposed that the criteria were intended to define the minimum symptoms necessary for diagnosis rather than to guide patient assessment. Thus, paradoxically, nonpsychiatrists assigned more
Protein Abnormalities in Macrophages Bearing Asbestos
Authors: P. Lemkin, L. Lipkin, C. Merril, S. Shifrin
Journal: Environmental Health Perspectives (1980)

Computerized techniques for the evaluation of O'Farrell two-dimensional electrophoretic gels have been applied to proteins derived from asbestos bearing macrophages. Preliminary results indicate definite changes in the protein content of cells depending on fiber phagocytosis.
A Case of a Laboratory Animal Feed with High Estrogenic Activity and Its Impact on <i>in Vivo</i> Responses to Exogenously Administered Estrogens
Journal: Environmental Health Perspectives (1998)

Bisphenol A Diglycidyl Ether as a Potential Metabolic Source of Bisphenol A * Ethylene glycol monobutyl ether-used as a solvent for mineral oils in spray lacquers, vamish removers, and metal cleaners * Glutaraldehyde-used as a disinfectant and sterilizing agent, and in adhesives, electrical products, dental materials, tanning of leathers, and photographic developing * Methyleugenol-used as an insect altrctant and as a maior constituent of clove oil, which is used in spices, perfumes, and favorings * Oxymetholone-used to promote weight gain and in the treatment of debilitafing diseases, serious infections, bums, trauma, and anemia * Triethanolamine-used in the manufacture of surfactants, textiles, waxes, polishes, herbicides, toilet goods, oil emulsions, and pharmaceuticals
Oxygen concentration delivered by Venturi masks with in-line humidification
Authors: W. A. Speir
Journal: JAMA (1971)

Venturi masks (Ventimasks) designed to deliver 24%, 28%, 35%, and 40% oxygen were tested under clinical and laboratory conditions to determine the effect of in-line humidification on the oxygen concentration delivered. Percent oxygen concentration was determined at specific intervals over a 24-hour period, with and without the use of a jet humidifier at the oxygen source. Contrary to the manufacturer's statement, the results of our study indicate that-in-line humidification has no effect on delivered oxygen concentration.
Substance abuse and adolescent suicidal behavior
Authors: F. E. Crumley
Journal: JAMA (1990)

Evidence suggests a significant association between use of psychoactive substances among adolescents and suicidal behavior among adolescents during the past two decades. Accumulating evidence, although not unanimous, supports the hypothesis of psychoactive substance abuse among adolescents as a risk factor for a range of suicidal behavior—ideation, attempted suicide, and completed suicide. With increasing rates of psychoactive substance abuse for the adolescent population during the past 20 years, this appears to be an increasingly important factor. It is not known if the association is causal. Psychoactive substance abuse appears to be associated with a greater frequency and repetitiveness of suicide attempts, more medically lethal attempts, a measured seriousness of intention, and greater suicidal ideation. Additional data support a specific association between alcohol intoxication and suicide by firearms among adolescents. Adolescents who abuse psychoactive substances, particularly those with any type of depressive disorder, appear to be at higher risk for suicidal behavior and may need appropriate psychiatric treatment. (<i>JAMA</i>. 1990;263:3051-3056)
阿达木单抗在斑块型银屑病成人患者中的长期安全性
Authors: C. Leonardi, K. Papp, B. Strober, D. Thaçi, R.B. Warren, S. Tyring, D. Arikan, M. Karunaratne, W.C. Valdecantos
Journal: British Journal of Dermatology (2019)

阿达木单抗是一种用于治疗银屑病的强力药物,专门被设计模拟正常人体分子,因此被归类为一种“生物”药。它通过抑制身体中一种被称为“肿瘤坏死因子 α” (TNF‐α) 的化学“细胞因子”的活动性来减轻炎症。此项来自美国的研究的目的是评估接受阿达木单抗治疗银屑病患者中的长期安全性。作者们调查了来自 3727 名接受此药患者的数据,作为记录了不良事件(AE,指用药时的不良副作用)的 18 项不同临床试验的一部分。总体而言,5,429.7 名患者‐年龄中有 16,536 例 AE(每 100 患者‐年龄有 304.6 例 AE)。患者‐年龄 (PY) 指患者的数量乘以他们被纳入此研究中的时间长度。最常见的 AE 是鼻咽炎(一种常见的喉部主诉)、上呼吸道感染和头痛(分别为 23.7、12.9 和 7.9 例 AE 每 100 PY)。严重感染、结核和机会性感染的发生率分别为 1.8、0.3 和 0.02 例 AE 每 100 PY。不包括非黑色素瘤性皮肤癌 (NMSC) 的恶性肿瘤(癌症)的发生率为 0.8 例 AE 每 100 PY。NMSC 和黑色素瘤的发生率分别为 0.6 和 0.2 例 AE 每 100 PY。作者们得出结论,在这项对接受阿达木单抗治疗的银屑病患者进行的分析中,AE 率保持稳定;相对于较早的研究,没有发现新的安全性信号(如 AE 增多)。
Complications of Methysergide Therapy
Authors: Peter H. Slugg
Journal: JAMA (1970)

Methysergide has been implicated as a causative agent of inflammatory fibrotic processes. A positive direct Coombs' test, associated with a hemolytic anemia, was obtained from a patient who had been receiving methysergide and who also had retroperitoneal fibrosis and mitral insufficiency. It is likely that the valvular disease, retroperitoneal fibrosis, and hemolytic anemia are all part of an autoimmune process induced by methysergide.
Autosensitivity Diseases
Authors: John H. Vaughan, Eugene V. Barnett, John P. Leddy
Journal: New England Journal of Medicine (1966)

Rheumatoid ArthritisMany etiologies have been postulated for rheumatoid arthritis. Perhaps the most popular, year in and year out, has been that the disease is due to some form of infection. Both the pathology and the serology of the disease are consistent with chronic infection, but they are also consistent with any other chronic immunizing process. In the absence of any reproducible demonstration of an infective agent in rheumatoid arthritis, new attention is being given to the possible roles in pathogenesis of the autoantibodies in the disease.Rheumatoid Factors66 These autoantibodies to γG globulin (anti-γG globulins) are a hallmark of . . .
Tamoxifen encouraging for breast cancer
Authors: M. Korcok
Journal: JAMA (1981)

A new report on a Canadian study shows tamoxifen citrate to have considerable promise in the treatment of premenopausal women with breast cancer. But the investigators emphasize that tamoxifen needs more study before it can be considered the "maneuver of choice" for treatment of this group of patients. (This is a reference to a recent editorial in the<i>New England Journal of Medicine</i>[1981;305:575-576] that claimed, partly on the basis of an earlier report on the same Canadian study, that tamoxifen is now "the endocrine maneuver of choice" for premenopausal women with breast cancer.) At present, tamoxifen can be considered another modality in the treatment sequence, said Kathleen I. Pritchard, MD, assistant professor of medicine, University of Toronto Faculty of Medicine. Pritchard made these cautionary remarks in an interview following presentation of the study results to the meeting of the Royal College of Physicians and Surgeons of Canada in Toronto.
A RUBBER STOPPER FOR CONTAINERS USED IN PREPARING BLOOD SERUM FOR INTRASPINAL INJECTIONS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neonatal bladder injury occurring after umbilical artery catheterization by cutdown
Authors: J. M. Kaufman
Journal: JAMA (1983)

Umbilical artery catheterization is a widely used technique for monitoring sick neonates. When it is performed by cutdown, the proximity of peritoneum, urachus, and bladder makes these structures vulnerable to injury. Three neonates experienced bladder perforation that resulted from umbilical artery catheterization by cutdown. The diagnosis was aided by measuring electrolyte levels in the umbilical fluid and was confirmed by cystography. Conservative treatment was successful in one neonate, but two required operative repair of the bladder laceration. (<i>JAMA</i>1983;250:2968-2970)
The epidemiology of bacillary angiomatosis and bacillary peliosis
Authors: J. W. Tappero
Journal: JAMA (1993)

<h3>Objective.</h3> —To determine environmental risk factors for bacillary angiomatosis-bacillary peliosis (BAP), and to confirm infection with<i>Rochalimaea</i>species. <h3>Design.</h3> —Case-control study. <h3>Setting.</h3> —Community and university hospitals and clinics. <h3>Patients.</h3> —Case patients (N=48) had biopsy-confirmed BAP. Controls (N=94) were matched to patients by institution and by human immunodeficiency virus (HIV) serological status. <h3>Main Outcome Measures.</h3> —Clinical information was obtained from medical records. Subjects were queried about environmental exposures. Univariate odds ratios (ORs) with 95% confidence intervals (Cls) were determined. Bivariate analyses were performed on variables associated with disease by univariate analysis. DNA from 22 available case-patient tissues and from 22 control tissues was amplified with the polymerase chain reaction (PCR) using primers designed to detect<i>Rochalimaea</i>species. <h3>Results.</h3> —We identified five HIV-negative, immunocompetent case patients; one HIV-negative, immunodeficient case patient; and 42 HIV-positive case patients. There were no significant differences between case patients and controls by race, sex, age, or risk factors for HIV infection. Owning a cat (OR, 2.8; CI, 1.4 to 5.8) and history of a recent cat lick (OR, 1.95; CI, 1.0 to 3.8), cat scratch (OR, 3.7; CI, 1.7 to 8.0), or cat bite (OR, 3.9; CI, 1.8 to 8.9) were associated with disease in the univariate analysis. In bivariate analyses, only the variables representing traumatic contact with a cat (bite or scratch) remained associated with disease. No other environmental exposure was associated with disease. The PCR amplified a DNA fragment of the size expected for<i>Rochalimaea</i>species in all 22 case-patient tissue specimens. <h3>Conclusions.</h3> —These data suggest that BAP is a new zoonosis associated with both traumatic exposure to cats and infection with<i>Rochalimaea</i>species or a closely related organism. (<i>JAMA</i>. 1993;269:770-775)
Mr Helms
Authors: Joseph E. Hardison
Journal: JAMA (1983)

Mr Helms was a boy's man because he was a boy at heart. He owned several acres of land, a pickup truck, a.22-caliber rifle, a dog, and a fishing pond, and he always had time for me. He was self-made as they say. He didn't have much education, could read, but didn't see the need for reading more than the newspaper or the<i>Almanac</i>. He had china-blue eyes, no teeth, and didn't make a sound when he laughed, even when he laughed hard. He didn't smoke, drink, cuss, or brag, and he was the best shot with a rifle I have ever seen. One day we were fishing in his pond when he broke his line, leaving his cork floating free. He shot, hitting just under the cork, throwing it high in the air and back toward him. After the third shot, it was within easy reach. Another time, he