tbuckley/cabot-search huggingface dataset:
Demonstration of Multiple Phenotypic Diversity in a Murine Melanoma of Recent Origin&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN4"&gt;4&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1981)

The purpose of these studies was to examine whether the metastatic heterogeneity that is frequently found in serially transplanted neoplasms could be observed in a murine melanoma of recent origin. The primary K-1735 melanoma that arose in an inbred C3H/HeN murine mammary tumor virusnegative (C3H−) mouse was transplanted once into an immunosuppressed recipient and then established in culture. Cells from the fifth in vitro passage were used to produce clones. The parent K-1735 and 22 cloned lines were tumorigenic in syngeneic and outbred N:NIH(S) nude mice. Metastatic properties were assessed by observing the ability of the cells to produce pulmonary and extrapulmonary lesions after they were injected iv into 6-week-old C3H− mice. The number of metastases produced, their relative size, and pigmentation varied dramatically among the clones. Only 2 of 22 clones were indistinguishable from the parent tumor. Most of the nonmetastatic (but tumorigenic clones) were also nonmetastatic in 3-week-old nude mice, which suggests that the absence of metastasis formation was not merely due to their immunologic rejection by the normal C3H− mouse. Control subcloning experiments demonstrated that the procedure of cloning in vitro was not responsible for the variability among the clones. The clones did not differ in their karyotype or cell size, but they did differ in their growth rate in vitro. These phenotypes, however, did not correlate with metastatic propensity. In conclusion, the K-1735, a murine melanoma of most recent origin, is heterogeneous and contains subpopulations of cells with diverse biologic behavior.
Nurses in a Crossfire
Authors: D. Bonta Hiscoe
Journal: JAMA (1970)

The Lansing (Mich) Visiting Nurse Association (VNA) and its Coordinated Home Care Program have been examined, with particular attention paid to the nurse's position and problems within the medical community. It is apparent that these nurses are already functioning as a special type of physician's assistant. Many problems are unresolved, but their role offers important opportunity for increased service in the future.
A Textbook of Gynaecological Surgery
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Carotid Bruit or Carotid Stenosis: What Is the Significance?
Authors: Christopher K. Zarins
Journal: JAMA (1981)

The carotid bruit has long been recognized as an indicator of possible atherosclerotic disease at the carotid bifurcation and possible stroke. While there is no disagreement that patients with cerebrovascular symptoms need prompt examination and treatment, the clinical implication of an asymptomatic carotid bruit is unclear. Does the bruit indicate a significant carotid artery stenosis? Are such patients at increased risk for stroke? More precisely, what is the risk of stroke or death without antecedent transient neurological symptoms that might prompt diagnosis and treatment? Reports in the literature dealing with the clinical course of patients with asymptomatic carotid disease have provided conflicting information. The risk of stroke has been reported to be as high as 19% in patients with asymptomatic carotid bruits<sup>1</sup>and as low as 2% in patients with angiographically proved stenosis followed up to 12 years.<sup>2</sup>The debate continues in the articles by Busuttil et al (p
The second phase of priority setting Goodbye to the simple solutions: the second phase of priority setting in health care Fairness as a problem of love and the heart: a clinician's perspective on priority setting Israel's basic basket of health services: the importance of being explicitly implicit
Authors: S. Holm, J. E Sabin, D. Chinitz, C. Shalev, N. Galai, A. Israeli
Journal: BMJ (1998)

# The second phase of priority setting {#article-title-2} Editorial by Klein This article was presented at the second international conference on priorities in health care in London on 8-10 October 1998 This week sees the second international conference on priorities in health care in London. To mark the occasion we are publishing three of the papers that will be presented at the conference. Each illustrates, in a different way, how thinking about priority setting in health care has developed over the past few years. No longer is the search for a rational set of decision making rules thought adequate: the process is seen to be more complex. # Goodbye to the simple solutions: the second phase of priority setting in health care {#article-title-3} A picture of a famous statue of a small angry boy in Frognerparken in Oslo adorns the cover of the second Norwegian report on priority setting in health care, published in 1997 (figure).1 It is not evident what has made him angry, but maybe he is a youthful politician who is angry because yet another report has claimed that questions about priorities have no easy solutions and somebody dares to speak the word rationing. Or he may be a junior healthcare economist stamping his foot because the QALY has been maligned yet again. Or he may be a citizen unable to understand that an affluent society cannot give sufficient health care to all those in need. All these reactions could easily be caused by the Norwegian report1—and by the report from the Danish Council of Ethics in late 19962 and several less official interventions in the Scandinavian debates about priority setting in health care in the late 1990s. Crying Boy by Gustav Vigeland, 1926-33 These debates are characterised by mounting disenchantment with simple solutions to the problems and by a shift in emphasis from the product of priority setting to the process of priority setting. In this … Correspondence to: Dr Chinitz
Noncontraceptive Estrogen Use and the Occurrence of Ovarian Cancer&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1982)

Female residents of six counties in Washington and Utah in whom ovarian cancer was diagnosed during 1975–79 were interviewed concerning prior use of noncontraceptive estrogens. Interviews with a random sample of women drawn from these counties were obtained for comparison. Taken as a whole, women with epithelial ovarian tumors reported estrogen use for 1 year or more somewhat more often than did controls [relative risk (RR) = 1.3, 95% confidence interval (Cl) =0.9-1.8]. The pro-portion of women who had used estrogens varied according to the histology of their tumor; notably, of 17 women with endometrioid tumors, 12 had used estrogens (RR=3.1, 95% CI = 1.0-9.8). The excess risk of endometrioid carcinoma related to estrogen use was not further increased when these hormones were taken for long durations, in high doses, or proximate to the time of diagnosis. Neither was there any evidence of increased risk from estrogen use in the small group of women with clear cell tumors, a histologic tumor type believed to be closely related to endometrioid carcinoma. Thus the observed association between menopausal estrogen use and the occurrence of ovarian endometrioid tumors should be interpreted cautiously until the results of additional studies are available.
Preventive Medicine and Hygiene.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial Board and Contents
Authors: Paul Craze, Susanne Brink, Paige Shaklee, Margriet Ten Napel, Ria Otten, Patrick Scheffmann, Göran Arnqvist, Spencer Barrett, Michael Bell, Brendan Bohannan, Ragan Callaway, Stephen Carpenter, James Clark, Paul Dayton, Rodolfo Dirzo, Andrew Dobson, Michael Donoghue, Douglas Irwin, Yoh Iwasa, Stephen Jackson, Christian Köner, William Laurance, Georgina Mace, Robert May, Harold Mooney, Craig Moritz, Randolph Nesse, Sarah Otto, Svante Pääbo, Linda Partridge, David Penny, Andrew Read, Daven Presgraves, Benjamin Sheldon, Christine Simon, Boris Worm
Journal: Trends in Ecology & Evolution (2018)
Fellowships, Grants, Awards
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Fellowships, Grants, Awards Get access JNCI: Journal of the National Cancer Institute, Volume 84, Issue 13, 1 July 1992, Pages 1050–1051, https://doi.org/10.1093/jnci/84.13.1050 Published: 01 July 1992
Jerome Cornfield 1912–1979
Journal: JNCI Journal of the National Cancer Institute (1980)

Journal Article Jerome Cornfield 1912–1979 Get access Marvin Schneiderman, Ph.D., Marvin Schneiderman, Ph.D. National Cancer InstituteBethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Samuel Greenhouse, Ph.D. Samuel Greenhouse, Ph.D. George Washington UniversityWashington, D.C. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 65, Issue 1, July 1980, Pages 1–2, https://doi.org/10.1093/jnci/65.1.1 Published: 01 July 1980
Ultraviolet radiation, melanocytic naevi and their dose-response relationship
Authors: T.D. NGUYEN, V. SISKIND, L. GREEN, C. FROST, A. GREEN
Journal: British Journal of Dermatology (1997)

Melanocytic naevi on the face and neck of 110 Brisbane secondary school students aged 16–17 years were mapped according to specified regions to investigate the dose-response relationship between ultraviolet (UV) radiation and melanocytic naevi. Highest naevus density occurred in regions receiving a mean UV dose of 0.2–0.4 relative to the vertex while densities were low in minimally and maximally exposed regions. This pattern of naevus distribution was unaffected by sex or phenotypic features such as skin colour or degree of freckling. These findings suggest that there is a narrow dose range over which UV radiation can effectively promote the proliferation of melanocytes. A comparison of the regional distribution of naevi on the face and neck with that of solar keratoses appearing over 1 year on the heads of residents of a neighbouring town has shown them to differ significantly. This study may shed some light on the unknown, yet expectedly complex, relation of UV radiation to melanocytic naevi.
Chromosomes of L-M Mouse Cells and Variants&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1966)

Journal Article Chromosomes of L-M Mouse Cells and Variants Get access Richard E. Giles, Richard E. Giles Department of Microbiology, The University of Michigan, Ann Arbor, Michigan 48104 Search for other works by this author on: Oxford Academic PubMed Google Scholar Donald J. Merchant, Donald J. Merchant Department of Microbiology, The University of Michigan, Ann Arbor, Michigan 48104 Search for other works by this author on: Oxford Academic PubMed Google Scholar Ellen Masselink Ellen Masselink Department of Microbiology, The University of Michigan, Ann Arbor, Michigan 48104 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 37, Issue 5, November 1966, Pages 663–676, https://doi.org/10.1093/jnci/37.5.663 Published: 01 November 1966 Article history Received: 11 April 1966 Published: 01 November 1966
Continuous Venous Catheterization in Children
Authors: Arno R. Hohn
Journal: JAMA (1966)

PEDIATRICIANS usually pride themselves on being able to administer fluids and medications by the intravenous route. By and large their success has merited the respect of medical colleagues. However, usually the patient must be immobilized for such therapy, and in order to avoid phlebitis, the site of venipuncture must be rotated every few days when prolonged treatment is necessary. It is in instances requiring long-term intravenous therapy that such management becomes difficult. Available veins are soon used up and the patient becomes uncomfortable and uncooperative. In this communication, the use of a simple method of intravenous therapy in eight children for two to six weeks is reported, wherein complete immobilization was not necessary and only a single puncture was needed. <h3>Materials and Method</h3> Special thin-walled, Teflon, 19- to 17-gauge catheters (a modification of the cannula described by Eisenberg<sup>1</sup>), 50 cm in length (Fig 1), were threaded percutaneously into the
Reproductive Characteristics of Mexican-American, Mainland Puerto Rican, and Cuban-American Women
Authors: Christine A. Stroup-Benham
Journal: JAMA (1991)

Data from the Hispanic Health and Nutrition Examination Survey were used to investigate reproductive characteristics of Hispanic females aged 15 to 45 years. Mexican-American and Puerto Rican women reported approximately 1.9 and 1.7 live births each, respectively, whereas Cuban-American women reported 1.1. Mexican-American women were more likely to be using oral contraceptives and were more likely to have had a hysterectomy or an oophorectomy than were Cubans and Puerto Ricans. The largest percentage of tubal ligations were found among Puerto Rican women. Mexican women who had been pregnant in the previous 12 months were more likely than their Puerto Rican and Cuban-American counterparts to be breastfeeding. Further research is needed to investigate the decision processes and/or cultural variations that may be responsible for these differences in reproductive traits across national origin groups. (<i>JAMA</i>. 1991;265:222-226)
Bronchobiliary Fistula
Authors: PETER W. BLUE, H JAMES VERSTEEG, FRANK N. COLE, JOHN E. LEWIS, NASSER GHAED
Journal: Clinical Nuclear Medicine (1983)

BLUE, PETER W. M.D., LTC, MC, USA; VERSTEEG, H JAMES M.D., COL, MC, USAF; COLE, FRANK N. M.D., CPT, MC, USA; LEWIS, JOHN E. M.D., CPT, MC, USA; GHAED, NASSER M.D., COL, MC, USA Author Information
Uretric Obstruction in Gardener's Syndrome
Authors: R Batstone, S Sharma, H Bickerstaff, R Persad, P Doyle
Journal: Journal of the Royal Society of Medicine (1996)

Desmoid tumours in Gardener's syndrome are a rare cause of ureteric obstruction. We report two cases of ureteric obstruction caused by desmoids, in a mother and daughter.
Diagnostic Study of Suspected Hydrocephalus
Authors: Robert L. McLaurin
Journal: JAMA (1969)

An approach to the study of an infant with macrocrania is outlined. It is noted that intracranial pathologic processes other than hydrocephalus may cause cranial enlargement, and the diagnostic approach permits this differential diagnosis. If hydrocephalus is present, the diagnostic study then permits evaluation of the location of spinal fluid obstruction and the severity of deformity and damage of the neural tissue. It must be emphasized, however, that no plan can be rigid for such evaluation, and the investigator must exercise clinical judgment in the planning and execution of the various steps in the diagnostic examination.
Highlights of the 1987 EDUCATION ISSUE
Authors: Anne E. Crowley
Journal: JAMA (1987)

The first EDUCATION ISSUE of<i>JAMA</i>, published on Sept 21, 1901, contained an article entitled "Medical Education," which editorialized on several topics, one of which was "Changes in Our Medical Schools Necessary to Meet Modern Conditions." In this 87th EDUCATION ISSUE ofTHE JOURNAL, the editorial by Drs Martini and Schwarz calls attention to several changes in the environment of medical education that present challenges to the current system. They call for innovative responses to these challenges to make medical education more responsive to the health care needs of the population and to the changing system of medical care provision. <h3>Medical School Enrollment</h3> The number of applicants to US schools accredited by the Liaison Committee on Medical Education (LCME) for the 1986-1987 year decreased by 1570 individuals. Of the 31323 applicants, 17092 students were accepted by at least one school for enrollment in fall 1986. The number of first-time enrolled
Two New Reports Help Put Nation's No. 1 Killer Disease Challenges Into Perspective for 1993
Authors: Phil Gunby
Journal: JAMA (1993)

AMERICAN HEART Association officials have just issued their 1993<i>Facts</i>and<i>Statistics</i>booklets about heart disease and stroke. But they clearly are looking beyond this year and perhaps beyond this decade. Noting that people who may not appear to be at high risk "account for the vast majority of sudden death victims in absolute numbers, perhaps 80% of the deaths per year," these booklets set a goal of identifying such potential victims. If research can meet this challenge, it is predicted confidently, "it will be possible to devise broader strategies to prevent sudden cardiac arrest." As it is, the association told science reporters at a Monterey, Calif, seminar last week: "About half of all deaths from heart disease are sudden and unexpected, regardless of the underlying disease. Thus, 50% of all deaths due to atherosclerosis of the coronary arteries are sudden, as are 50% of deaths due to degeneration of
Acyclovir Treatment of Herpes Zoster Infections
Authors: Fredric T. Serota
Journal: JAMA (1982)

Three patients in whom herpes zoster infections developed following bone marrow transplantation were treated with acyclovir. The patients experienced pain relief within 24 hours of starting treatment. The progression of their skin lesions halted within 1, 2, and 4 days of therapy, respectively, and healed completely within two weeks of therapy. Pharmacokinetic studies indicated that acyclovir plasma concentration-time profiles approximated biexponential equations. The drug half-lives were 3.91, 3.83, and 3.40 hours, respectively. Acyclovir was not myelotoxic and may be helpful in aborting varicella-zoster virus infections in bone marrow transplant recipients. (<i>JAMA</i>1982;247:2132-2135)
A Formula for Calculating the Dosages of Drugs in Emergencies
Authors: W. G. Byerly, G. Melnick, J. A. Barone
Journal: JAMA (1987)

<h3>To the Editor.—</h3> After reviewing the recent American Heart Association (AHA) Standards and Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiac Care,<sup>1</sup>we would like to comment on a potential problem in the recommendations for preparation of isoproterenol, epinephrine, and norepinephrine infusions for use in pediatric resuscitation. The formula given to calculate the amount of drug needed to prepare an infusion is 0.6 times the body weight (in kilograms) equals the milligrams of drug added to the diluent tomake 100 mL. For this dilution, 1 mL/h will deliver 0.1 μg/kg/min.<sup>1(p2967)</sup>There are two problems with this formula that make it impractical for emergency settings. The first problem involves the number of drug ampules needed to prepare the infusions and the second concerns the volume of drug that must be used to prepare the infusions. The pediatric population is defined as children from 1 month to 15 years of
The Management of High-Risk Pregnancy
Authors: Jack W. Pearson
Journal: JAMA (1974)

ANY practicing obstetrician should have a schema for the identification and management of his high-risk pregnancy population. The science of obstetrics has progressed so rapidly in the last two decades that it has become increasingly difficult for the average practitioner to keep up with advances, much less to incorporate them into his practice. In many instances, it may serve the patient best if she is referred to a perinatologist or a regional center that is better prepared to manage all of the ramifications of a truly complicated pregnancy. Not infrequently, however, geography or a patient's circumstances may demand the services of the nonspecialist. The high-risk pregnancy candidate may be identified either on her initial visit or during her prenatal course. In the first instance, the need for caution may be recognized on the basis of past history. A poor past obstetric performance that may have required a cesarean section for
Interactions Between Viral and Genetic Factors in the Origin of Mammary Tumors in Mice&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;
Authors: Bentvelzen, P., Daams, J. H., Hageman, Philomena, Calafat, Jero, Timmermans, A.
Journal: JNCI Journal of the National Cancer Institute (1972)

Journal Article Interactions Between Viral and Genetic Factors in the Origin of Mammary Tumors in Mice Get access P. Bentvelzen, P. Bentvelzen 2Radiobiological Institute TNO. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. H. Daams, J. H. Daams 3Antoni van Leeuwenhoekhuis. Search for other works by this author on: Oxford Academic PubMed Google Scholar Philomena Hageman, Philomena Hageman 3Antoni van Leeuwenhoekhuis. Search for other works by this author on: Oxford Academic PubMed Google Scholar Jero Calafat, Jero Calafat 3Antoni van Leeuwenhoekhuis. Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Timmermans A. Timmermans 3Antoni van Leeuwenhoekhuis. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 48, Issue 4, April 1972, Pages 1089–1094, https://doi.org/10.1093/jnci/48.4.1089 Published: 01 April 1972