tbuckley/cabot-search huggingface dataset:
Correction:<i>Tislelizumab in Chinese patients with advanced solid tumors: an open-label, non-comparative, phase 1/2 study</i>
Authors: Yu-Pei Chen, Ya-Qin Wang, Yan-Ping Mao, Ying-Qing Li, Shuo-Yu Xu, Xiao-Min Li, Qing-Mei He, Shi-Wei He, Xiao-Jing Yang, Yuan Lei, Yin Zhao, Jing-Ping Yun, Yingqin Li
Journal: Journal for ImmunoTherapy of Cancer (2020)
Abstract 3471: Ambient particulate air pollution and ectopy - The Environmental Epidemiology of Arrhythmogenesis in WHI (EEAWHI), 1999–2004
Authors: Duanping Liao, Eric A Whitsel, Yinkang Duan, Hung-Mo Lin, Miguel Quibrera, Richard L Smith, Donna J Peuquet, Ronald J Prineas, Zhu-Ming Zhang, Garnet Anderson
Journal: Circulation (2007)

We investigated relationships between exposures to ambient particles (PM) < 2.5 μm (PM2.5) or <10 μm (PM10) in diameter and ventricular or supraventricular ectopy as detected by a resting, standard...
THE GROWING NECESSITY OF COLLEGE TRAINING PREPARATORY TO MEDICAL STUDY.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Utility of anticoagulation in portal venous thrombosis before and after liver transplant
Authors: Patricia Abellan Alfocea, Eva Julissa Ortega Suazo, Flor Nogueras López, María Dolores Espinosa Aguilar, Mercedes Angeles Gonzalez Sanchez, Ana Gila Medina, Eduardo Redondo, Maria Angeles Lopez Garrido
Journal: Journal of Hepatology (2020)
The Pitfalls of Deducing Ethics From Behavioral Economics: Why the Association of American Medical Colleges Is Wrong About Pharmaceutical Detailing
Authors: Thomas S. Huddle
Journal: The American Journal of Bioethics (2010)

The Association of American Medical Colleges (AAMC) is urging academic medical centers to ban pharmaceutical detailing. This policy followed from a consideration of behavioral and neuroeconomics research. I argue that this research did not warrant the conclusions drawn from it. Pharmaceutical detailing carries risks of cognitive error for physicians, as do other forms of information exchange. Physicians may overcome such risks; those determined to do so may ethically engage in pharmaceutical detailing. Whether or not they should do so is a prudential judgment about which reasonable people may disagree. The AAMC's ethical condemnation of detailing is unwarranted and will subvert efforts to maintain a realm of physician discretion in clinical work that is increasingly threatened in our present practice environment.
The AMA and the Armed Forces Medical Services
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Safety of Therapeutic Products Used for Hemophilia Patients
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Second Childhood
Authors: Arnold Wagner
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Complete resolution of pure red cell aplasia in a patient with chronic lymphocytic leukemia following antithymocyte globulin therapy
Authors: C A Radosevich, L I Gordon, S C Weil, R J Marder, S T Rosen
Journal: JAMA (1988)

Pure red cell aplasia has been reported to be associated with chronic lymphocytic leukemia. It has been proposed that this complication may be a result of T-cell populations that suppress erythropoiesis. It has been postulated that antithymocyte globulin might reverse this abnormality by eliminating the population of suppressor T cells responsible for this inhibition. We treated a 74-year-old man who had B-cell chronic lymphocytic leukemia and pure red cell aplasia that was refractory to cytotoxic and corticosteroid therapy with equine antithymocyte globulin and methylprednisolone sodium succinate. This therapy resulted in a durable complete remission of both the chronic lymphocytic leukemia and the pure red cell aplasia and was associated with normalization of helper/suppressor T-cell ratios in the bone marrow. Antithymocyte globulin should be investigated further as a therapeutic modality for patients with pure red cell aplasia associated with chronic lymphocytic leukemia.
Enterovirus Surveillance—United States, 2000-2001
Journal: JAMA (2002)

Enteroviruses are common viruses associated with diverse clinical syndromes, ranging from minor febrile illness to severe, potentially fatal conditions (e.g., aseptic meningitis, encephalitis, paralysis, myocarditis, and neonatal enteroviral sepsis). A total of 68 enterovirus serotypes are recognized, including 65 nonpolio enteroviruses. Individual serotypes have different temporal patterns of circulation and can be associated with different clinical manifestations. This report describes trends in reported enterovirus infections in the United States during 2002-2004, including widespread circulation of two serotypes, echovirus 9 and echovirus 30, commonly associated with aseptic meningitis outbreaks. Monitoring circulating enteroviruses helped identify these two serotypes as primary causes of aseptic meningitis outbreaks in 2003. Increased state laboratory participation and timely reporting by all laboratories to CDC would further increase the public health utility of enterovirus surveillance.
AUSTRALIA
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
VIENNA
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Decreasing Liver Biopsy Complications
Authors: Guadalupe Garcia-Tsao
Journal: Annals of Internal Medicine (1993)

Letters1 September 1993Decreasing Liver Biopsy ComplicationsGuadalupe Garcia-Tsao, MD, James L. Boyer, MD, and Peter McPhedren, MDGuadalupe Garcia-Tsao, MDSearch for more papers by this author, James L. Boyer, MDSearch for more papers by this author, and Peter McPhedren, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-5-199309010-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Kovacs and colleagues object to prebiopsy hemostasis screening using prothrombin time increment-over-control and Ivy bleeding time as safety measures. They emphasize the importance of bleeding history and suggest that the prothrombin time INR be substituted for the prothrombin time increment.We agree that a history taken from an alert, responsive patient, including medication history (especially regarding aspirin and nonsteroidal anti-inflammatory drugs [NSAIDs]) is probably more important than any laboratory test for preoperative or pre-procedure hemostasis. All our patients are specifically instructed not to take aspirin or NSAIDs for at least 10 days before prebiopsy blood tests and the ...References1. Suchman AL, Griner PF. Diagnostic uses of the activated partial thromboplastin time and prothrombin time. Ann Intern Med. 1986; 104; 810-16. Google Scholar2. Rodgers RP, Levin J. A critical reappraisal of the bleeding time. Semin Thromb Hemost. 1990; 16:1-20. Google Scholar3. Johnston Y, McPhedran P, Weissman L, Anderson G. Interpretation of prolonged bleeding times: extended survey (Abstract). Clin Res. 1986; 34:369A. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1993Volume 119, Issue 5Page: 436-437KeywordsAspirinBiopsyHemorrhageHemostasisInternational normalized ratioLaboratory testsLiverNSAIDsProthrombin timeSurgery Issue Published: 1 September 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Somatostatin Inhibition of Gonadotropin-Releasing Hormone Neurons in Female and Male Mice
Authors: Janardhan P. Bhattarai, Attila Kaszás, Seon Ah Park, Hua Yin, Soo Joung Park, Allan E. Herbison, Seong Kyu Han, István M. Ábrahám
Journal: Endocrine Reviews (2010)

Previous studies indicate that somatostatin regulates gonadotropin secretion. We investigated here whether somatostatin has direct effects on GnRH neurons in the adult male and female mice. Dual-labeling immunofluorescence experiments revealed the presence of somatostatin-immunoreactive fibers adjacent to GnRH neurons, and three-dimensional confocal reconstructions demonstrated apparent somatostatin fiber appositions with 50–60% of GnRH neurons located throughout the brain in both male and female mice. Perforated patch-clamp recordings from GnRH-green fluorescent protein neurons revealed that approximately 70% of GnRH neurons responded in a dose-dependent manner to 10–300 nm somatostatin with an acute membrane hyperpolarization and cessation of firing. This effect persisted in the presence of tetrodotoxin and amino acid receptor antagonists, indicating a direct postsynaptic site of action on the GnRH neuron. The identity of the somatostatin receptors underlying this action was assessed using GnRH neuron single-cell RT-PCR. Of the somatostatin receptor subtypes, the sstr2 transcript was the most prevalent and detected in both males and females. The expression of sstr2 by GnRH neurons was confirmed in the sstr2 knockout/LacZ knock-in mouse line. Electrophysiological studies demonstrated that the sstr2-selective agonist seglitide exerted acute hyperpolarizing actions on GnRH neurons identical to those of somatostatin. Together, these studies reveal somatostatin, acting through sstr2, to be one of the most potent inhibitors of electrical excitability of male and female GnRH neurons identified thus far.
A randomized trial of a family physician intervention for smoking cessation
Authors: D. M. Wilson
Journal: JAMA (1988)

We assessed the impact of three conditions on one-year smoking cessation rates. Physicians in 70 community general practices were randomly allocated by practice to one of three groups: In the usual care group, smoking patients were to receive the care they normally would receive. In the gum only group, physicians were asked to speak to patients about smoking cessation and offer nicotine gum. In the gum plus group, physicians were trained in the experimental intervention. This intervention involved advice to stop smoking, the setting of a quit date, the offer of nicotine gum, and four follow-up visits. Smoking cessation was measured by self-report after one year and validated using saliva cotinine measures. Using a criterion of at least three months of abstinence, 8.8% of the patients of the trained physicians had stopped smoking at the one-year follow-up compared with 4.4% and 6.1% of the patients in the usual care and gum only groups, respectively. (<i>JAMA</i>1988;260:1570-1574)
METABOLISM DURING THE REPRODUCTIVE CYCLE
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Internal Medicine (2013)

Long-Acting Bronchodilators in COPD 1175Long-acting inhaled ß-agonists and anticholinergics, first-line medications for chronic obstructive pulmonary disease (COPD), have both been associated with adverse cardiovascular events.When choosing between the two, patients and physicians would benefit from knowing which has the least cardiovascular risk.Gershon and coauthors conducted a retrospective cohort study of older patients with COPD who were new users of one of these medications to compare their risks of cardiovascular hospitalizations and emergency department visits.They found that new use of long-acting ß-agonists and long-acting anticholinergics were associated with similar increased risk of cardiovascular events.A commentary by Woodruff follows.Invited Commentary 1184 Cardiac Arrest Incidence and Survival 1186To investigate whether hospitals with high case survival rates are effective at preventing cardiac arrest, Chen and colleagues examined a large national registry using multivariable hierarchical regression.They found that hospitals with exceptional rates of survival for inhospital cardiac arrest are also better at preventing cardiac arrests, even after adjusting for patient case mix.This relationship was partially mediated by measured hospital attributes.
Abstract C47: Acetaminophen enhances the chemotherapeutic effect of cisplatin and paclitaxel on human ovarian carcinoma cells in vitro
Authors: Yingjen Jeffrey Wu, Alexander J. Neuwelt, Leslie L. Muldoon, Edward A. Neuwelt
Journal: Cancer Research (2011)

Abstract Chemoresistance is commonly found in treating cancer patients. Acetaminophen enhances the cytotoxicity of cisplatin in human liver cancer cells by depleting glutathione and increasing production of toxic metabolites in vitro. The objective of this study was to investigate potential molecular mechanisms for chemoenhancement in nonhepatic cells. Human ovarian carcinoma SKOV3 cells were treated with cisplatin or paclitaxel with or without acetaminophen in vitro. Cellular mitochondrial membrane potential and reactive oxygen species concentration was measured by using JC-1 and DHR123 stain, respectively. Cellular platinum level was analyzed using ICP-MS. Apoptosis and signaling pathways were examined by immunoblotting and immunohistochemical analyses. A 2-h incubation with acetaminophen (10 mM) decreased cellular glutathione levels and increased mitochondrial membrane potential without affecting reactive oxygen species. Overnight acetaminophen treatment increased reactive oxygen species and enhanced both cisplatin- and paclitaxel-induced apoptosis. In contrast, the combination of acetaminophen with cisplatin but not paclitaxel blocked nuclear translocation of nrf2, a transcription factor that has been implicated in regulation of the antioxidant response. Pretreatment with acetaminophen for 2 h did not affect cellular platinum uptake when compared to cisplatin alone. Regardless of different oxidative stress pathways involved between cisplatin and paclitaxel, the addition of acetaminophen enhanced the cytotoxic effects of both chemotherapeutic drugs in human ovarian carcinoma cells. Our results suggested that acetaminophen could be used as a chemoenhancing adjuvant for conventional chemotherapy drugs in treating ovarian and other malignancies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the Second AACR International Conference on Frontiers in Basic Cancer Research; 2011 Sep 14-18; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2011;71(18 Suppl):Abstract nr C47.
Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease*1, *2
Authors: J GEORGE
Journal: Hepatology (1995)

To determine whether cytochrome P450 proteins were differentially altered in severe chronic liver diseases, we examined 50 livers removed at liver transplantation from patients with end-stage cirrhosis, including 18 with and 32 without cholestasis, and compared the results with 21 histologically normal livers. NADPH-cytochrome c reductase activities were unaltered in microsomes from cirrhotic livers. Total cytochrome P450 content was significantly reduced. The catalytic activities of four xenobiotic-metabolizing P450s and the level of the corresponding proteins were differentially altered. Thus, P450 3A-supported testosterone 6β-hydroxylase activity and 3A protein appeared to be reduced, but only in the subgroup without cholestasis was this change significant. In contrast, 2E1 and the related N,N-dimethylnitrosamine N-demethylase activity were clearly reduced in livers from patients with cholestatic forms of cirrhosis but appeared not to be changed in other cirrhotic livers. Similarly, P450 2C protein was reduced only in patients with severe chronic cholestasis. Finally, P450 1A2 and 1A2-supported ethoxyresorufin O-deethylase activity were significantly reduced in hepatic microsomes from patients with both types of advanced liver disease. In summary, these data demonstrate that cytochrome P450 proteins are selectively altered in severe chronic liver disease, some being profoundly decreased, others less so or not at all. Our results also suggest that there may be different patterns of altered hepatic P450 expression according to the presence or absence of cholestasis in patients with cirrhosis severe enough to require transplantation.