tbuckley/cabot-search huggingface dataset:
Embolization of a solitary kidney. Successful embolectomy after nine days
Authors: M. J. Sullivan
Journal: JAMA (1972)

In a patient who had undergone right nephrectomy for renal carcinoma 20 years earlier, anuria developed following left renal artery embolism. Nine days later, renal artery embolectomy was successfully performed. This represents the longest reported anuric interval between the onset of symptoms and successful treatment. Intraoperative, intra-arterial instillation of human fibrinolysin seemed to facilitate the removal of thrombotic material from the distal renal artery branches. Renal artery occlusion is reversible, at least occasionally, after prolonged nonfunction.
Circumcision-Reply
Authors: C. Henry Kempe
Journal: JAMA (1982)

<h3>In Reply.—</h3> I am sorry that I did not keep my answer short. Personally, I believe in circumcision for reasons stated by the writers. I wanted to make a point, obviously not well, that customs—medical, social, or religious—that are acceptable by one culture may not be acceptable to another.<sup>1</sup>
Diagnosis of gonorrhea in male patients by culture of uncentrifuged first-voided urine
Authors: W. C. Feng
Journal: JAMA (1977)

THE VAST majority of gonococcal infections in men are localized in the uniquely accessible male urethra, where the disease usually manifests itself as an acute or chronic urethritis with recognizable symptoms and signs. The urethral site of these infections offers an unusually favorable opportunity for a simple method of collecting laboratory specimens, because the urethra can easily be washed out by the patient himself with a small amount of his own readily available urine. The report by Moore et al<sup>1</sup>in 1973 is apparently the only major study in the past 20 years on the use of urine for diagnosis of gonorrhea in the male. Riggs,<sup>2</sup>in a short letter to the editors ofThe Journalin 1975, recommended the use of a few drops of urine passed on a swab which is used as a culture sample. With the exception of Riggs' brief note, all previous studies
Macroregenerative nodules in a series of adult cirrhotic liver explants: Issues of classification and nomenclature*1
Authors: P HYTIROGLOU
Journal: Hepatology (1995)

Macroregenerative nodules (MRNs), probably representing a pathway for human hepatocarcinogenesis, are generally classified into type I MRNs (or ordinary adenomatous hyperplasia) and type II MRNs (or atypical adenomatous hyperplasia), on the basis of imprecise definitions of cytological and architectural atypia. It is currently believed that type II MRNs are probably true precursors of hepatocellular carcinoma (HCC), whereas type I lesions may simply represent large regenerative nodules. A series of 155 consecutive adult cirrhotic liver explants were examined for evidence of MRNs, HCC, and liver cell dysplasia (LCD) of large and small cell types, and their appearance, in terms of proposed classification schemes, was reviewed. There was evidence indicating that the presence of either type of MRN was associated with an increased incidence of HCC (all MRNs, P < .00019; type I MRNs, P < .067; type II MRNs, P < .012) compared with cirrhotic livers without MRNs. A subset of younger patients with a large (uncountable) number of MRNs in their livers, who did not show any increased incidence of carcinoma, was identified. Excluding these cases from statistical analysis, all associations were strengthened, implying either that malignant progression had not had time to occur in this younger population or that these nodules were simply large regenerative nodules without malignant potential. MRNs from these livers were histologically indistinguishable from MRNs occurring in more limited numbers, although atypical changes other than large cell type LCD were less frequent. No independent association between LCD of large cell type and HCC was found in the entire series. Deleting this feature from the criteria for cytological atypia resulted in a stronger association of both types of MRNs with HCC (redefined type II MRNs/HCC, P < .0001; redefined type I MRNs/HCC, P < .0306). Some of the type II MRNs remaining after exclusion of large cell type LCD showed "borderline" changes insufficient for a diagnosis of HCC, but most type II MRNs (82%) contained expansile "nodule-in-nodule" growth patterns. The conclusions of this report are that (1) histological examination of type I MRNs is insufficient in many cases to distinguish large regenerative nodules from neoplastic ones; (2) LCD of large cell type should not be used as a criterion for terming an MRN atypical; and (3) expansile "nodule-in-nodule" formation in MRNs should be considered to represent evidence of architectural atypia.
Induction of Monooxygenation in Rainbow Trout by Polybrominated Biphenyls: A Comparative Study
Authors: Clifford R. Elcombe, John J. Lech
Journal: Environmental Health Perspectives (1978)

Two commercial polychlorinated biphenyl mixtures (Aroclor 1254 and Aroclor 1242) and one polybrominated biphenyl mixture (FireMaster BP-6) were examined for their abilities to induce hepatic microsomal monooxygenation in rainbow trout (Salmo gairdneri). Pretreatment of rainbow trout with Aroclors 1254 and 1242 (150 mg/kg IP) resulted in an approximate 10-fold induction of arylhydrocarbon (benzo[a]pyrene) hydroxylation, ethoxycoumarin-O-deethylation and ethoxyresorufin-O-deethylation within 7 days after injection. These enzyme activities remained elevated above control values for at least 2-3 weeks. Administration of FireMaster BP-6 (150 mg/kg IP) also resulted in an induction of several monooxygenase activities. Arylhydrocarbon (benzo[a]pyrene) hydroxylation, ethoxycoumarin-O-deethylation and ethoxyresorufin-O-deethylation were increased by 6-, 3,- and 25-fold, respectively. Only the latter two activities remained elevated two weeks post-injection. Ethylmorphine-N-demethylation was unaffected by the polyhalogenated biphenyls. Significant increases in P-450 hemoprotein were not observed after pretreatment with any of the polyhalogenated biphenyls studied.
THE BALTIMORE MEETING.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase III trial of personalized chemotherapy based on serum tumor marker decline in poor-prognosis germ-cell tumors: Results of GETUG 13.
Authors: Karim Fizazi, Lance C. Pagliaro, Aude Flechon, Jozef Mardiak, Lionnel Geoffrois, Pierre Kerbrat, Christine Chevreau, Remy Delva, Frederic Rolland, Christine Theodore, Guilhem Roubaud, Gwenaelle Gravis, Jean-Christophe Eymard, Jean-pierre Malhaire, Claude Linassier, Muriel Habibian, Florence Journeau, Christopher Logothetis, Stephane Culine, Agnes Laplanche
Journal: Journal of Clinical Oncology (2013)

LBA4500 Background: Poor-prognosis GCT (IGCCCG, J Clin Oncol 1997) remains a challenge with no improvement in the 50% survival demonstrated in phase III trials for 25 years. Day 21 serum tumor marker decline rate identified a subgroup of patients (pts) with a better outcome (J Clin Oncol 2004, 22: 3868-76). The hypothesis we tested in this study is that treatment allocation based on early tumor marker decline will improve the progression-free survival (PFS). Methods: Pts with IGCCCG poor-prognosis GCT were treated with a first cycle of BEP. AFP and hCG were assessed at day 18–21: 1) Pts with a favorable decline continued BEP for a total of 4 courses (Fav-BEP); 2) Pts with an unfavorable decline were randomized to receive either BEP (Unfav-BEP) or a dose-dense regimen (Unfav-dose-dense), consisting of paclitaxel-BEP plus day-10 oxaliplatin x 2 cycles, followed by 2 cycles of cisplatin, ifosfamide, and continuous infusion bleomycin (depending on lung function) + G-CSF. The primary endpoint was PFS (hypothesis: 20% difference, type 1 error: 5%, power 80%, 196 randomized pts needed). Results: 263 pts were enrolled and 254 were evaluable at day 21 (6 early deaths, 3 withdrawals): 51 pts (20%) had favorable tumor marker decline and 203 had unfavorable decline (randomized: 105 Unfav-dose-dense arm, 98 Unfav-BEP). The prognostic value of early tumor marker decline (Fav-BEP vs Unfav-BEP) was confirmed: 70% vs 48% for 3-year PFS (p=0.01), and 84% vs 65% for overall survival (OS) (p=0.02). The 3-year PFS was 59% in the Unfav-dose-dense arm vs 48% in the Unfav-BEP arm (p=0.05; HR: 0.66 [0.44-1.00]). 3-year OS was 73% and 65%, respectively. More ≥ grade 2 neurotoxicity (21% vs 4%) and more hematotoxicity occurred in the dose-dense arm, with no excess febrile neutropenia (17% each arm) or toxic deaths (1 each arm). Salvage high-dose chemotherapy + stem-cell transplant were required in 6% in the Unfav-dose-dense arm and 16% in the Unfav-BEP arm (p=0.01). Conclusions: An algorithm of individualized treatment intensification determined by the rate of early tumor marker decline reduces the risk of progression or death in men with poor-prognosis GCT. Clinical trial information: NCT00104676.
NCI Monographs No. 8 Smokeless Tobacco Use in the United States
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article NCI Monographs No. 8 Smokeless Tobacco Use in the United States Get access JNCI: Journal of the National Cancer Institute, Volume 81, Issue 17, 6 September 1989, Page 1342, https://doi.org/10.1093/jnci/81.17.1342 Published: 06 September 1989
Wipe test for the detection of indoor allergens
Authors: R. Polzius, T. Wuske, J. Mahn
Journal: Allergy (2002)

Background: The determination of house dust mite and cat allergens is a prerequisite for qualified assessment of exposure risk indoors. We describe the validation of integrated wipe tests comprising a porous sampling pin for the collection of settled house dust and an immunochemical test set-up for specific analysis of dust associated allergens. Methods: Wipe tests comprised an immunochromatographic test system and a porous sampling pin for collecting dust by manually wiping a surface. Two different wipe tests were developed with specificity to cat allergen (Fel d 1) and to dust mite allergen (Der p 2/f 2). One-hundred and fifty on-site determinations for each of the allergens in 50 different households completed the field study to validate the analytical system. Reference analysis was based on collection of dust with a vacuum cleaner and analysis of dust associated allergens by ELISA. Results: The wipe tests were found to produce semiquantitative results (class 0–3) on-site within 10 min of analysis time. For dust mite (cat) allergen the median of class 0–3 was 119 (263), 812 (844), 2708 (5670) and 8000 (56 800) ng/g dust, respectively. With respect to cut-off levels for dust mite (cat) allergens the clinical sensitivity was 62% (79%) and the clinical specificity was 94% (92%). Conclusions: The wipe tests proved to be a reliable tool for indoor allergen exposure screening, suitable for use even by untrained persons. This may have an impact on compliance with allergen avoidance measures.
115 RANDOMIZED CONTROLLED TRIAL COMPARING EFFECTS OF SEDATION FOR UPPER GASTROINTESTINAL ENDOSCOPY WITH PROPOFOL VERSUS MIDAZOLAM ON PSYCHOMETRIC TESTS AND CRITICAL FLICKER FREQUENCY IN CIRRHOTICS
Authors: A. Agrawal, B.C. Sharma, P. Sharma, R. Uppal, S.K. Sarin
Journal: Journal of Hepatology (2012)
The Role Of Glutamate Neurotoxicity In Hypoxic-Ischemic Neuronal Death
Authors: D. Choi
Journal: Annual Review of Neuroscience (1990)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
The “six-and-twelve” score in a prospective cohort of patients with hepatocellular carcinoma treated with trans-arterial chemoembolization following a fixed schedule
Authors: Marco Sanduzzi Zamparelli, Marta Burrel, Anna Darnell, Víctor Sapena, Marta Barrufet, Patricia Bermudez, Alejandro Sotomayot, Neus Llarch, Gemma Iserte, Ernest Belmonte, Alejandro Forner, Jordi Rimola, Carmen Ayuso, Jordi Bruix, María Reig
Journal: Journal of Hepatology (2020)
Hyponatremic Encephalopathy After Endometrial Ablation-Reply
Authors: J. Carlos Ayus
Journal: JAMA (1994)

<h3>In Reply.</h3> —Dr Lyon points out that during endometrial ablation, a discrepancy between intake and output would be reflected by a weight gain. This appears to be an excellent way to monitor fluid balance in such patients. Dr Mangar recommends careful monitoring of the patient undergoing hysteroscopy, including frequent measurements of serum electrolyte levels and the quantity of irrigating fluid used. Such a cautious approach should contribute toward prevention of the syndrome that we described. Dr O'Connor recommends use of an ethanol-containing irrigation fluid, combined with end-tidal breath analysis for ethanol levels. This apparently has been successful during TURP. An increased breath alcohol level in expired air would alert the physician that an excess of fluid had been reabsorbed. This could be an excellent way to monitor such patients, if the required technology were widely available. Dr Corson, alarmingly, suggests vasopressin administration to patients undergoing endometrial ablation. Many of the
BUCHAREST
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ocular Therapeutics: For Physicians and Students.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sex-Linked Hydrocephalus: Report of Two Families, with Chromosomal Study of Two Cases
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
International medical education. Common elements in divergent systems
Authors: C. A. Carlson
Journal: JAMA (1991)

An assortment of medical education systems currently operate throughout the world, reflecting variations in populations, histories, societal and cultural traditions, political systems, and stages of economic development. Despite their many differences, common elements can be identified in many of these systems. A geographic maldistribution of physicians, insufficient funding for education, an imbalance between specialization and general practice, and inadequate mechanisms to evaluate medical competence are serious concerns in many countries today. On the positive side, there is a shared focus on community-based educational initiatives, provision of education through ambulatory care settings, and a trend toward integrated, problem-based educational strategies. To gain more comprehensive information about current approaches to medical education, the American Medical Association conducted the 1990 International Survey of Medical Education. <h3>SURVEY METHOD AND PURPOSE</h3> The survey, which consisted of 31 multiple-part questions, was designed to identify similarities and differences among the numerous medical education systems. It was mailed
Abortion
Authors: James H. Ford
Journal: JAMA (1974)

<h3>To the Editor.—</h3> I would like to add another case history to Dr. Hussey's "Cause of Death" (229:75, 1974). A 20-year-old Texas woman was flown to Los Angeles in 1972 by a planned-parenthood affiliate for a saline abortion; two days later she died. The coroner's report signed her out as death due to gangrene of the right ovary. The coroner's inquest jury found that there was evidence of negligence in postabortion care, and called her death accidental. The<i>true</i>cause of death was<i>legal abortion</i>. The point I'm trying to make is that liberal abortion enthusiasts have, for years, been trying to sell the public (and the profession) the idea that illegal abortion has been the cause of a high mortality and that legalizing abortion can and does reduce that high mortality significantly. Their chief evidence (other than anecdotal reports, and grossly self-serving, gratuitous assertions) for such a thesis is
BRITISH DISPATCH
Authors: V Wright
Journal: Annals of the Rheumatic Diseases (1990)

Bugs, bones, and bioengineering have occupied British rheumatologists in the past year, along with treatment initiatives, advanced radiology, and educational strategies. CausationAt a symposium in Rochdale on 'Milestones and millstones in rheumatic diseases' Denman sug- gested that antibodies are largely irrelevant, immune complexes are probably trivial, and advanced microbiological techniques should enable us to identify the initiating organisms of certain rheumatic disorders.The glycosylation defect, reported by Roitt and his colleagues at the Middlesex Hospital, excited enough interest for the British Society of Rheumatology to give it a separate session at its scientific meeting in April.One of the few silver linings to the cloud of HIV infection is the clues to the pathogenesis of seronegative polyarthritis and psoriasis, which may come from data gathered in London and in New York.