tbuckley/cabot-search huggingface dataset:
OC-012 Cytokine RNA profiles from Crohn's disease-derived,<i>E coli</i>-laden macrophages isolated by laser capture microdissection (1 cm)
Authors: N Rayment, B N Hudspith, T Elliott, J Brostoff, J Sanderson
Journal: Gut (2010)

<h3>Introduction</h3> Intestinal macrophages are important in the regulation of gut homeostasis. We and others have reported the persistence of strains of <i>E coli</i> in lamina propria macrophages in patients with Crohn9s disease (CD). Studies of CD associated <i>E coli</i> show only low grade pathogenicity in keeping with hypothesis that there is a primary macrophage defect enabling bacterial persistence rather than a property of the <i>E coli</i> themselves. In a previous study we have successfully optimised the conditions necessary to extract RNA from laser dissected macrophages isolated from mucosal biopsies. This methodology has permitted the accurate identification and analysis of macrophages among a heterogeneous population of cells found within the lamina propria. <h3>Methods</h3> Snap frozen mucosal biopsies were taken at routine colonoscopy from patients with CD (n=25) and controls (n=10) with normal mucosa. In addition, paired biopsy samples were taken from CD patients (n=6) from affected and unaffected areas. Using LCM combined with immuno-histochemistry (IHC), CD-68 positive macrophages containing clusters of <i>E coli</i> and those free of bacteria were identified, captured and total RNA extracted. qRT-PCR was then used to measure the expression of markers of macrophage activation (CD163, iNOS, COX-2) and cytokines (IL-1β, IL-6, IL-8, GM-CSF and TNF α). <h3>Results</h3> A significant reduction in the expression of TNFα (p=0.001), IL-1b (p=0.01), IL-8 (p=0.004), GM-CSF (p=0.001), iNOS (p=0.001) and Cox-2 (p=0.0027) was seen when comparing CD macrophages laden with bacteria to unladen macrophages and controls. Expression of IL-6 was also reduced in laden macrophages but did not reach significance (p=0.49). Expression of CD163 was significantly increased in <i>E coli</i> laden macrophages (p=0.001) compared to unladen macrophages and controls. Laden and unladen macrophages isolated from affected and unaffected areas in the same patient had cytokine profiles which appeared to reflect the presence/absence of <i>E coli</i> and were therefore independent of inflammatory status. <h3>Conclusion</h3> In patients with CD, we have shown altered expression of cytokines in <i>E coli</i> containing macrophages compared to those free of bacteria and to healthy controls. <i>E coli</i> persistence appears mainly to lead to reduced pro-inflammatory cytokine expression. The downstream effects of this in terms of chronic inflammation require further evaluation.
Parallel 37: Hepatitis C: Pre‐Approval Clinical Studies II
Authors: Fulya Gunsar, Ilker Turan, Galip Ersoz, Zeki Karasu, Omer Ozutemiz, Eric Lawitz, Fred Poordad, Robert Hyland, Lin Liu, Hadas Dvory, Phillip Pang, Diana Brainard, Julio Gutierrez, Julio Guti- Errez, Paul Kwo, Michael Bennett, Stanley Wang, Hugo Vargas, David Wyles, J Overcash, Peter Ruane, Benedict Maliakkal, Asma Siddique, Bal Bhandari, Ran Liu, Chih-Wei Lin, Teresa Ng, Federico Mensa, Jens Kort, Daniela Sia, Andrew Harrington, Zhongyang Zhang, Genis Camprecios, Sara Toffanin, Agrin Moeini, M Fiel, Ke Hao, Monica Higuera, Oriana Miltiadous, Laia Cabellos, Helena Cornella, Yujin Hoshida, Sander Florman, Myron Schwartz, Josep Llovet
Journal: Hepatology (2015)

Three hundred forty-one patients were on lamivudine, 60 were on adefovir, 188 were on entecavir, 467 were on tenofovir, and 32 were on combination therapies.ROC analysis for the predictive values of HCC scores showed that AUROC values were 0.804 for CU-HCC, 0.809 for REACH-B and 0.882 for GAG-HCC.These values were similar in patients without therapy and with entecavir and tenofovir therapies as in the literature.The most predictive GAG-HCC score had sensitivity of 97.3% and negative predictive value of 99.9%.Conclusion: In this large cohort of Caucasian HBV patients, all of these scores had good predictive values for HCC development both in patients on treatment and in patients who did not receive antiviral treatment.
Military medicine has NATO role in Balkans
Authors: P. Gunby
Journal: JAMA (1996)

MILITARY MEDICAL support is available to the approximately 20 000 US Implementation Force ground troops who are spreading out along North Atlantic Treat Organization peacekeeping corridors in the former Yugoslavia. A US Army medical brigade already stationed in Europe is playing a key role. Other medical resources include the US Navy's shipboard hospital beds and the US Air Force's aeromedical evacuation system. As the US troops began to deploy, President Clinton said there "could be incidents with people [associated with various factions of the civil war] who still have not given up their hatred." The White House added that poor roads, severe weather, and millions of still-undetected land mines add to the hazards. While US troops are moving into the northeastern Bosnia area around Tuzla, the 74th Medical Group—Provisional from Wright-Patterson Air Force Base near Dayton, Ohio, has turned over United Nations (UN) hospital facilities at Zagreb, Croatia, to military
The role of radiation therapy in endometrial cancer
Authors: J. F. Wilson
Journal: JAMA (1980)

RECENT emergence of adenocarcinoma of the uterine corpus as the most common invasive gynecologic malignant neoplasm in the United States is attributable to several concurrent factors. Earlier detection of carcinomas of the uterine cervix, still in noninvasive stages, through widespread cytologic screening, is chief among these, but it also may be attributed to an absolute increase in the incidence of endometrial cancer noted during the past decade.<sup>1</sup>Despite observations that these neoplasms may be undergoing transition to greater virulency, more than three fourths of patients continue to present with an early clinical stage of disease. Good results in treating these stages have been reported often but are not sufficiently satisfactory to justify the often complacent attitude of some therapists. In our aging population, with its reduced parity levels, and potential exposure to known or suspected carcinogens, it is essential to optimize available therapy. The challenge presented by this increasingly
Lymphangitis after tuberculin tests
Authors: J B Morrison
Journal: BMJ (1984)

Lymphangitis after tuberculin testsLymphangitis after tuberculin testing has rarely been reported.I report 12 such reactions seen during 1979-83, five after Mantoux and seven after Heaf tests.I had not seen any in the previous 39 years. CommentHigham and Jayson showed that 79°" of patients with rheumatoid arthritis or back pain used self prescribed analgesics.2Although there is
Correction
Journal: BMJ (1960)

ANY QUESTIONS? is important.'The early popularity of this operation has faded, and it should be undertaken only after full investigation and when other remedies have failed.Psychotherapy may be, combined with any physical method or used alone.As a rule obsessional patients are intelligent, but they can be extremely obstinate; they plead for help, but resist treatment to an astonishing extent.This is part of the disorder, and does not imply an overdose of original sin.Hypnosis is almost useless, and analysis of the passive type is disappointing.Provided the co-operation of the patient can be gained, relief may be obtained if the analyst is prepared to take an active part in the analysis, and in particular to give attention to the " time factor" in the symptomatology': the fear of the future; the urge to make time stand still; and in the background the fear of death.So far as age is considered, a man aged 44 would be acceptable for any form of treatment.
Prognosis and Relationship of Histologic Features to Clinical Stage
Authors: Robert J. Lukes
Journal: JAMA (1972)

The significance of the wide spectrum of histologic findings observed in Hodgkin's disease was an enigma until recently, accounting for its unique and somewhat uncertain position in the scheme of malignant neoplasms. Paragranuloma and sarcoma, the histologic types reported by Jackson and Parker,<sup>11</sup>was considered well established as prognostically signficant in a small proportion of cases,<sup>12</sup>but clinical staging appeared to provide a more reliable general basis for prognosis and determination of therapy. Investigation in the past decade has focused attention on a defective immunologic system as a result of the demonstrated inability of the host to develop delayed hypersensitivity and delay in homograft rejection. Recently, we have been able to shed some light on the histologic types through a new approach relating the histologic features to manifestations of the host reaction.<sup>12-14</sup>The relationship between histologic findings and the clinical stages of Hodgkin's disease emphasizes the significance
Effect of Acetophenetidin Free from Aceto-4-Chloranilid on the Lifespan of Erythrocytes in Phenacetin-Eaters
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
REAC/TS Handles 'Hot' Topics
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial Board
Authors: Treasa Creavin, Sara Cullinan, Ellie Carr, Suado Nur, Lara Crow, Mat Mccutcheon, Philip Patenall, Neill Sharp, K Anderson, New York, Usa Borst, C Epstein, San Francisco, Usa Fink, W Gehring, Switzerland Guarente, H Horvitz, E Koonin, E Meyerowitz, S Moreno, D Sherratt, J Smith, M Takeichi, Japan Kobe, Martin Oti, Martijn Huynen, Han Brunner, Jennifer Hay, Sankar Subramanian, Craig Millar, Elmira Mohandesan, David Lambert, Itay Tirosh, Naama Barkai, Amanda Larracuente, Timothy Sackton, Anthony Greenberg, Alex Wong, Nadia Singh, David Sturgill, Yu Zhang, Brian Oliver, Andrew Clark, Charalambos Kyriacou, Alexandre Peixoto, Federica Sandrelli, Rodolfo Costa, Eran Tauber, Elaine Mardis, Mihai Pop, Steven Salzberg, Mildred Cho, Pardis Sabeti, Sarah Tishkoff, Jan Kammenga, Patrick Phillips, Mario De Bono, Agnieszka Doroszuk, Marc Cruts, Christine Van Broeckhoven, Gabino Sanchez-Perez, Alex Mira, Gábor Nyirö, Lejla Pasic, Francisco Rodriguez-Valera, Micrornas Flex Their Muscles, Eva Van Rooij, Ning Liu, Eric Olson, Susan Keall
Journal: Trends in Genetics (2008)
Clinical value of serum immunoreactive trypsin concentration.
Authors: W S Ruddell, C J Mitchell, I Hamilton, J P Leek, J Kelleher
Journal: BMJ (1981)

The clinical value of estimation of serum concentrations of immunoreactive trypsin was evaluated by studying 46 healthy controls, 23 controls in hospital, 44 patients with chronic pancreatic disease, and 184 patients with non-pancreatic conditions in which pancreatic disease commonly enters into the differential diagnosis. Serum trypsin concentration had a log normal distribution in the controls, and the calculated normal range was considerably wider than that previously reported. The concentration was abnormal in only 13 out of 27 patients with chronic pancreatitis and was extremely variable in patients with pancreatic cancer. Abnormal results occurred in 11% of the patients with non-pancreatic disease. Eighteen patients had a subnormal trypsin concentration, of whom six did not have pancreatic disease and 12 had either chronic pancreatitis or pancreatic cancer. There was no correlation between serum trypsin concentration and mean tryptic activity as measured by the Lundh test. Of 11 patients with pancreatic steatorrhoea, only seven had subnormal trypsin concentrations. There results suggest that the serum concentrations of immunoreactive trypsin has a low specificity and sensitivity for pancreatic disease and does no reflect the degree exocrine insufficiency in patients with proved chronic pancreatitis.
European Perspectives
Authors: Peter Schwartz, Robert Krakoff, Peter Libby, Marc Pfeffer
Journal: Circulation (2009)

of medicine, the Brigham and Women's Hospital, was, "You beautifully illustrated through your personal research how carefully conducted basic and clinical studies can improve our mechanistic understanding of the pathogenesis of arrhythmias predisposing to sudden death.In the best definition of translational research, you have shown how these new insights provided the underpinnings for you to develop the hypothesis and design clinically directed rigorous investigations that have led to a better understanding and treatment of cardiovascular diseases."Even before the term "translational research" had entered the medical lexicon, Professor Schwartz was a master at identifying problems in patients, moving quickly to the laboratory to carry out fundamental studies that might provide solutions, and then testing these solutions in a clinical setting."The downside of my story," Professor Schwartz says, "is the old rule that a man's success is paid by his family.My wife and my kids had to deal with a husband and a father too often absent because even when at home I tend to work most of the evenings.I know that this is wrong but the truth is that I cannot help it-I keep thinking about my research problems.I am afraid that I am addicted to it: some people smoke marijuana, others tobacco, I smoke research.It's easier to stop than to slow down.I love the competition and this is not a 9 to 5 job.It's Luisella's miracle that we have preserved a wonderfully united and happy family."
Prostate-specific membrane antigen antibody–drug conjugate (PSMA ADC): A phase I trial in taxane-refractory prostate cancer.
Authors: D. P. Petrylak, P. W. Kantoff, R. C. Frank, N. D. Shore, Y. Rotshteyn, R. J. Israel, W. C. Olson, T. Ramakrishna, S. Morris
Journal: Journal of Clinical Oncology (2011)

4650 Background: PSMA type II transmembrane glycoprotein is expressed predominantly on the surface of prostate cancer cells. PSMA ADC, a fully humanized antibody to PSMA linked to the potent antitubulin agent monomethyl auristatin E (MMAE), binds PSMA and internalizes within prostate cancer cells where cleavage and release of free MMAE occur, causing cell cycle arrest and apoptosis. We report results from an ongoing phase I dose escalation study of PSMA ADC in subjects with taxane-refractory metastatic castration-resistant prostate cancer (mCRPC) after failure of a taxane-containing regimen. Methods: Key eligibility requirements included age ≥18 years and ECOG status of 0 or 1. PSMA ADC is administered by IV infusion Q3 weeks for up to 4 cycles. Adverse events, pharmacokinetics, prostate specific antigen (PSA) levels, circulating tumor cells (CTC), clinical disease progression, and immunogenic response are assessed. Serum PSMA ADC is measured by an enzyme-linked immunosorbent assay (ELISA) method, and free MMAE is measured by liquid chromatography/mass spectrometry/mass spectrometry (LC/MS/MS) method.Dosing cohorts were initiated at 0.4 mg/kg and has been completed in the 1.8mg/kg. Results: The demographics of 21 subjects enrolled were similar. Treatment has been generally well tolerated. Reversible changes in liver function tests and hematological parameters were observed at the highest doses. One subject at 1.8 mg/kg had an SAE of pancreatitis that resulted in death. Evidence for antitumor effects, as reflected by declines in PSA, CTC and/or bone pain, has been observed in four of twelve subjects treated at 1.6 or 1.8 mg/kg. Dose proportional increases in serum concentrations of PSMA ADC have been observed. No significant accumulation of PSMA ADC and/or free MMAE nor immunogenicity have been observed. An MTD has not been reached and dosing at 2.0 mg/kg is ongoing. Conclusions: In this first-in-man evaluation, PSMA ADC appears to be generally well tolerated, and has antitumor activity, as reflected by declines in PSA, CTC and bone pain. Ongoing enrollment will contribute to the establishment of an MTD and assessment of potential clinical utility of PSMA ADC for the treatment of mCRPC.
In Reply
Authors: Carlos Fernandez-del Castillo, Cristina R. Ferrone, Andrew L. Warshaw
Journal: Journal of Clinical Oncology (2006)

We agree with Dr Halm that an isolated measurement of CA19-9 concentration has limited value in the treatment decision of individual patients, and that there is a very broad range in the concentrations of this serum marker.It is because of the skewed distribution of the CA19-9 values that median, rather than mean, is routinely utilized in studies involving this marker.We in fact do state the range and quartiles of the values in the results section, and levels of nearly 19,000 were found in one of our patients.In addition to confirming previous studies that have correlated CA19-9 concentrations with tumor stage and survival, our study 1 shows by multivariate Cox model that a decrease in CA19-9 after resection, and an absolute value of less than 200 U/mL, are both independent prognostic factors predicting increased survival.The power of these two variables was as strong as T stage and absence of lymph node metastases.It is for this reason that we propose that postoperative CA19-9 values may be useful to stratify pancreatic cancer patients for adjuvant trials.
Manuscripts Approved for JNCI, October 10 to November 10, 1962
Journal: JNCI Journal of the National Cancer Institute (1962)

Manuscripts Approved for JNCI, October 10 to November 10, 1962 Get access JNCI: Journal of the National Cancer Institute, Volume 29, Issue 6, December 1962, Pages 1199–1200, https://doi.org/10.1093/jnci/29.6.1199-a Published: 01 December 1962
LETTER FROM NEW YORK
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IMPURE ICE.
Journal: JAMA (1891)

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MALPRACTICE.—DR. PARKER VINDICATED.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal