tbuckley/cabot-search huggingface dataset:
Comparative Carcinogenicity of &lt;italic&gt;N&lt;/italic&gt;-Butyl-&lt;italic&gt;N&lt;/italic&gt;-(3-carboxypropyl)-nitrosamine and &lt;italic&gt;N&lt;/italic&gt;-Butyl-&lt;italic&gt;N&lt;/italic&gt;-(4-hydroxybutyl)nitrosamine for the Urinary Bladder of (C57BL/6 × DBA/2)F&lt;sub&gt;1&lt;/sub&gt; Mice&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Charles C. Irving, William M. Murphy, Douglas S. Daniel
Journal: JNCI Journal of the National Cancer Institute (1984)

The carcinogenicity of N-butyl-N-(3-carboxypropyl)-nitrosamine [CAS: 38252-74-3; 4-(N-butyl-N-nitrosamino)butyric acid] in male and female (C57BL/6 × DBA/2)F1 mice was determined. N-Butyl-N-(3-carboxypropyl)nitrosamine given in the drinking water at a concentration of 3 mM (0.056%) for 13 weeks induced only carcinoma of the urinary bladder in both sexes. At 22–28 weeks, the incidences of bladder cancer in the male and female mice were 100 and 88%, respectively. These bladder tumors were classified histologically according to the frequency (%) of tumor type: pure transitional cell carcinoma, 42%; mixed (transitional cell carcinoma with squamous or glandular differentiation, or both), 28%; squamous cell carcinoma, 27%; and carcinoma in situ, 3%. No significant sex differences were observed. In comparative studies, the incidence of bladder cancer was 100% for both sexes after administration of 3 mM (0.052%) N-butyl-N-(4-hydroxybutyl)nitrosamine [CAS: 3817-11-6; 4-(butylnitroso-amino)-1-butanol] in the drinking water. The frequency of pure transitional cell carcinoma was 47%, which was not significantly different from that observed for the carboxypropyl compound. The frequencies of other types of bladder carcinoma induced by N-butyl-N-(4-hydroxybutyl)nitrosamine were the following: mixed, 8%; squamous cell carcinoma, 42%; and carcinoma in situ, 3%.
Clinical, Epidemiologic, and Pathologic Features of Cytocidal and Oncogenic Herpesviruses in South American Monkeys&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1972)

Clinical, Epidemiologic, and Pathologic Features of Cytocidal and Oncogenic Herpesviruses in South American Monkeys Get access R. D. Hunt, D.V.M., R. D. Hunt, D.V.M. New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 Search for other works by this author on: Oxford Academic PubMed Google Scholar L. V. Meléndez, D.V.M. L. V. Meléndez, D.V.M. New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 49, Issue 1, July 1972, Pages 261–272, https://doi.org/10.1093/jnci/49.1.261 Published: 01 July 1972
Transfer of Delayed Hypersensitivity
Authors: John A. Mohr
Journal: JAMA (1969)

Passive transfer of delayed skin hypersensitivity to purified protein derivative of tuberculin (tuberculin PPD) in five recipients who previously had negative reactions to tuberculin after receiving transfusions of whole blood from donors with known positive reactions has been observed. This reactivity has persisted for eight months, the period of observation. Similar passive transfer was also observed in one patient who received fresh plasma but this patient's skin reactivity disappeared after two months while his leukocytes remained "sensitive" to tuberculin. Passive transfer may occur with a variety of diseases and disease states which involve cell-mediated hypersensitivity. In the evaluation of conversion of tuberculin reactivity, one must consider the possibility of passive transfer by prior whole-blood transfusion.
Punctate palmoplantar keratoderma and malignancy in a four-generation family
Authors: H.P. STEVENS, D.P. KELSKLL, I.M. LEIGH, L.S. OSTLERE, K.D. MACDERMOT, M.H.A. RUSTIN
Journal: British Journal of Dermatology (1996)

We report a large kindred in which a punctate palmoplantar keratoderma (PPK) is associated with malignancy, including Hodgkin's disease, renal, breast, pancreatic and colonic adenocarcinomas. The family was traced through four generations, and over 520 individuals were identified, of whom 49 had punctate PPK. The punctate PPK appeared to be inherited as an autosomal dominant trait with variable penetrance. Ten of the 43 adults (23%) with punctate PPK developed malignancies, and five of these developed before the age of 50. Of the 271 unaffected individuals, six (2%) have developed malignancies, one prior to the age of 50. The association of keratoderma and malignancy is discussed.
Patient Identification In Blood Transfusions
Authors: Alvin M. Ring
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Regarding the LETTER to the Editor "Patient Identification for Laboratory Tests," (<b>218</b>:1572, 1971) which referred to the EDITORIAL, "Laboratory Tests, Misuse and Abuse" (<b>218</b>:90, 1971), the point is made that there should be a place on the transfusion request form on which the individual collecting the specimen for typing and cross-matching certifies that he has checked the order, properly identified the patient, and drawn the specimen from the appropriate patient. In our blood transfusion service, we believe that additional safeguards are necessary to prevent errors of identification, which account for probably 90% of transfusion mistakes.<sup>1</sup> Each patient having blood drawn for crossmatch is banded with a red wrist band into which is inserted a guide bearing his name and a specific transfusion number, which also appears on all forms, specimen tubes, and blood-bag. Prior to administering the blood the physician or his assistant must
Personal Hygiene Applied
Journal: JAMA (1946)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE AMERICAN ACADEMY OF MEDICINE.
Authors: Richard J Dunglison
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Respiratory Insufficiency Following Near-Drowning in Sea Water
Authors: John C. Warden
Journal: JAMA (1967)

After initial resuscitation, severe respiratory insufficiency jeopardized the recovery of a youth who nearly drowned in sea water. Lung compliance decreased to between 20% and 30% of normal for three days, and there was a persistent hypoxia. Marked roentgenographic changes in the lungs resolved almost completely over a three-day period. It is concluded that the respiratory insufficiency was due to a pneumonitis resulting from the aspiration of sea water, and that neither pulmonary edema nor reflex airway closure played a significant role.
Mammographic parenchymal patterns
Authors: John N. Wolfe
Journal: JAMA (1982)

<h3>To the Editor.—</h3> I would like to comment on the article by László Tabar, MD, and Peter B. Dean, MD, on breast parenchymal patterns (BPP) (1982;247:185) and the editorial by Myron Moskowitz, MD (1982;247:210). The material of Tabar and Dean is compared to my work. The patient population is entirely different. There is the usual problem of knowing whether or not investigators are classifying the same. I had the opportunity of reviewing a number of cases from this study and had some difficulty in classifying them, in that the radiographic technique as used in Sweden differs vastly from mine. There is no reference made to this cooperative effort; likely the authors did not have the chance to make correlations. Not to be lost is the fact that the authors do conclude that there is significance to the P2 and DY patterns insofar as risk for carcinoma is concerned. The incident
Study Questions Safety, Economic Benefits of Outpatient Tonsil/ Adenoid Surgery
Authors: Chris Anne Raymond
Journal: JAMA (1986)

"WE'RE ALL becoming cost conscious.... It stands to reason that if patients were to go home two to four hours after surgery, there could be a large savings. But we have to be careful that we don't compromise the patient's health. As our study states, you really should keep them eight hours after surgery, and by that time, there isn't much [cost] difference [involved in] keeping them overnight." Such were the comments of Don E. Gebhart, MD, clinical professor of otolaryngology, Ohio State University College of Medicine, Columbus. He and colleague Jeffrey S. Carithers, MD, resident clinical instructor in otolaryngology at the university, presented evidence to counter current pressure on physicians to discharge tonsilloadenoidectomy (T and A) patients the same day of surgery. Based on an analysis of nearly 3000 T and A procedures, they argue that early discharge may be both hazardous and economically unwarranted. They reported their study
Cleidocranial Dysostosis
Authors: R E Parrella, F Di Gregorio
Journal: JAMA (1963)

Cleidocranial dysostosis is a syndrome defined by some workers as "osteodental" insofar as it presents with variously associated skeletal and dental anomalies. The aetiology, clinical picture and pathological anatomy are analysed, stress being laid on dental anomalies and on dentoskeletal irregularities. Finally, two clinical cases observed in recent years at the University of Bari Odontostomatological Clinic are reported.
Smoking, coal, asbestos, and the lungs
Authors: J M Patrick
Journal: BMJ (1981)

admonished their GP.This provided strong indication of a need for specialists, the acknowledged experts in their technical field, to re-evaluate their approach to patients and by doing so include a more open exploration of the psychosocial issues which cause patients concern.We believe that these findings are most relevant to "dealing with the disadvantaged," who, it would appear, may feel inhibited in their encounters with the medical profession, especially those at consultant level.
Gastroesophageal Reflux
Authors: W Schwizer, M Fried
Journal: New England Journal of Medicine (1971)

Gastroesophageal reflux disease (GERD) is a common, typically chronic recurring disorder. The majority of patients with heartburn and regurgitation have intermittent symptoms for which they do not consult their physicians. The main long-term risk of esophagitis is adenocarcinoma arising from Barrett's metaplasia. There are two principle therapeutic strategies in the treatment of GERD. The use of prokinetic drugs aims at treating the primary motility disorder leading to reflux, whereas acid-suppressive therapy targets at the reduction of gastric acid production to prevent symptoms and complication of GERD. The cornerstone in the treatment of GERD are proton pump inhibitors (PPI). Patients with mild symptoms and rarely relapsing disease may be best treated intermittently. Longterm maintenance acid-suppressive therapy with PPIs is necessary in GERD patients with immediate and severe relapse. At present, eradication of Helicobacter pylori in GERD patients is not recommended. Antireflux surgery is an effective treatment to control gastroesophageal reflux. However, surgery is associated with a low, but still substantial morbidity, a low mortality of up to 0.5% and is only indicated in patients with pharmacological refractory reflux disease.
Osteoporosis and Its Treatment
Authors: Charles H. Chesnut
Journal: New England Journal of Medicine (1992)

Osteoporosis is common among postmenopausal women. Unfortunately, in the past it was frequently regarded by clinicians as a normal part of aging, with little need for therapeutic intervention; during the past decade, however, it has increasingly been perceived as a seriously disabling disease, warranting substantial involvement on the part of investigators, governmental agencies, and the pharmaceutical industry in the development and assessment of potential treatments. Such an involvement seems appropriate and is resulting in an increasing number of treatment options.In this regard, the study by Tilyard et al.1 in this issue of the Journal addresses the potential therapeutic efficacy . . .
Possible Role of Duodenogastric Reflux on the Development of Remnant Gastric Carcinoma Induced by &lt;italic&gt;N&lt;/italic&gt;-Methyl-&lt;italic&gt;N&lt;/italic&gt;′-nitro-&lt;italic&gt;N&lt;/italic&gt;-nitrosoguanidine in Rats
Journal: JNCI Journal of the National Cancer Institute (1984)

The relationship between operative procedures and the incidence of remnant stomach carcinoma was investigated in male Wistar rats orally treated with N-methyl-N′-nitro-N-nitrosoguanidine [(MNNG) CAS: 70-25-7; 1-methyl-3-nitro-1-nitrosoguanidine]. A total of 178 rats was divided into 5 groups: After gastrectomy in which half of the glandular stomach was removed, group 1 received Billroth II reconstruction; group 2 was given short Roux-en-Y reconstruction; group 3 had long Roux-en-Y reconstruction; group 4 received gastrotomy alone; and group 5 consisted of nonoperated control rats. The incidence of gastric adenocarcinoma in MNNG-treated rats was significantly higher in group 1 (38.9%) as compared with that in group 3 (7.1%) and that in group 5 (9.5%). All tumors developed in the gastroenteric anastomotic area. Histologic examination of the gastric mucosa revealed atrophic gastritis and erosion in the gastroenteric anastomotic area, especially in rats with carcinoma. These findings seem to implicate the duodenogastric reflux, especially the reflux of bile acids, in the development of remnant stomach carcinoma in rats.
Minimizing Complications of Bone Marrow Transplantation
Authors: Samuel Vaisrub
Journal: JAMA (1980)

In less than a decade since the Seattle team achieved a successful bone marrow transplantation,<sup>1</sup>this procedure has become an acceptable treatment for leukemia and a preferred treatment for severe aplastic anemia.<sup>2</sup>However, the success of this therapy is lessened by complicating infections and graft-vs-host reactions, with attendant graft rejection and mortality. Even though the donor is a family member with identical human leukocyte antigen, the risk of graft rejection hangs over the patient like the sword of Damocles. To reduce the risk of graft rejection, a conditioning immunosuppressive regimen is scrupulously followed. This usually entails using total-body irradiation, methotrexate for prevention of graft-vs-host reaction, and corticosteroids and antithymocyte globulin when this reaction develops. Despite such regimens the incidence of graft-vs-host disease remains high. Thomas and associates<sup>3</sup>reported the occurrence of this complication in 12 of 19 marrow transplant patients with acute myelogenous leukemia, five of whom
The "Normal" Range
Authors: Lila Elveback
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Dr. Keating met his death in an automobile accident before our paper was published. I have consulted with his colleagues, Dr. Lynwood Smith and others (Sections of Internal Medicine), and Dr. Don Jones and Dr. John McCall (Section of Biochemistry). We would like to make the following points concerning Dr. Gambino's comments. First, it is apparent from our paper that we were not estimating "maximum limits for the normal range" but rather the 2.5 and 97.5 percentage points of the distribution in healthy persons. Next, Dr. Keating's colleagues support his statement concerning the clinical significance of the falsenegative values on serum calcium in the range from 10.1 to 10.3. As reported from here and elsewhere,<sup>1-3</sup>borderline hypercalcemia with symptomatic hyperparathyroidism occurs in a small but significant percentage of patients demonstrated to have the disease. Its recognition depends upon an accurately established normal range using the refined
II. Medical Education: The Early Phases
Authors: Lester S. King
Journal: JAMA (1982)

When the early colonists came from England, the medical men who accompanied them belonged to the lower part of the professional spectrum. They were, for the most part, apothecaries and surgeons, more skilled in practice than in theory. After many decades, however, as life in the colonies became more attractive, better-trained men, often with university education, joined the immigrant ranks. In addition to those who had had some formal medical training in the mother country, the colonial practitioners included lay persons who had acquired a smattering of knowledge and whose ministrations were sought by those with no other recourse. In isolated communities there might be no other than self-appointed healers, whose good faith and intentions we do not doubt, whatever reservations we may have about their competence. From this latter group, there was a transition to the inevitable quacks and frauds. Ministers of the gospel often provided medical assistance, especially
Relationship Between Stimulating Mechanisms of Gastric Secretion in Dogs
Authors: Paul J. Jordan
Journal: JAMA (1967)

Observations by Straaten<sup>1</sup>and Unvas<sup>2</sup>suggested that the cephalic phase of gastric secretion was dependent on a neurohumoral mechanism originating in the antrum. Thein and Schofield<sup>3</sup>later provided critical evidence to support the concept that gastric secretion in response to vagal stimulation was partly due to vagal release of gastrin. Subsequently, it was demonstrated by Olbe<sup>4</sup>and ourselves<sup>5</sup>that antrectomy reduced the secretory response to cephalic stimulation by sham feeding. Olbe<sup>6</sup>further showed that administration of a subthreshold dose of gastrin restored to normal the sham feeding response reduced by antrectomy. That only a small amount of gastrin was required to permit full vagal response of parietal cells was suggested further by our work which estimated that vagally released gastrin approximated 16% of that released by direct chemical stimulation of the antrum.<sup>5</sup> The present experiments were designed to study further potentiation of acid
Bacterial Endocarditis Complicated by Myocardial Infarction in a Pediatric Patient
Authors: Henry M. Feder
Journal: JAMA (1982)

CLINICALLY apparent embolic episodes occur in about 20% of pediatric patients with bacterial endocarditis.<sup>1,2</sup>Emboli most frequently involve the lungs, brain, extremities, spleen, kidneys, and mesenteric vessels.<sup>1-3</sup>Emboli to the coronary arteries resulting in a myocardial infarction, while not uncommon in adults,<sup>4,5</sup>are rare in children<sup>6</sup>and usually result in sudden death.<sup>6-8</sup>The purpose of this report is to draw attention to the fact that myocardial infarction can complicate bacterial endocarditis in children, to discuss the appropriate therapy, and to document the favorable long-term outcome in a patient who survived with conservative therapy. <h3>Report of a Case</h3> A 15-year-old girl was admitted to Hartford Hospital, Hartford, Conn, in November 1978 because of acute onset of abdominal pain. At age 6 years, she had had rheumatic fever characterized by arthritis, erythema marginatum rash, and carditis that resulted in mitral insufficiency. Since then, she has received monthly
INDUSTRIAL LEAD POISONING
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Endocrine Function of Iodine
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal