tbuckley/cabot-search huggingface dataset:
POS0166 POLYARTICULAR JIA HAS A DISTINCT CO-INHIBITOR RECEPTOR PROFILE AMONG OTHER JIA SUBTYPES
Authors: E. Sag, Z. Balik, S. Sener, U. Kaya Akca, S. Demir, M. Kasap-Cuceoglu, E. Atalay, S. Bocutcu, T. Vural, Y. Bilginer, B. Deleuran, S. Özen
Journal: Annals of the Rheumatic Diseases (2022)

Background Juvenile idiopathic arthritis (JIA) is the most common inflammatory joint disease in children, driven by continuous T-cell activation.[1] T cell activation is counter-balanced by signals generated by co-inhibitory receptors (co-IRs) such CTLA-4, PD-1, LAG-3, and TIM-3.[2] Objectives We aimed to identify the role of co-IRs in the pathogenesis of different subtypes of JIA. Methods In total, we included 107 patients with oligoarticular JIA (n=67), polyarticular JIA (n=12), enthesitis related arthritis (n=17), systemic JIA (n=11) and healthy controls (HC, n=10). We collected plasma samples from the patients during the active phase of their disease. We measured the soluble plasma levels of co-IRs by commercial pre-defined cytometric bead array kits and their cellular expression by flow cytometry in blood mononuclear cells. We compared the plasma levels and cellular expressions of different coIRs within different JIA subgroups. Results IL-2 levels were lower than HC in all JIA subgroups. The polyarticular JIA group distinguished from the four different JIA subgroups, by having different co-IR pattern. In this specific subgroup, CTLA4, PD-1 and 4-1BB levels were higher than other groups. Polyarticular JIA is the more chronic and severe form of JIA, especially when compared to oligoarticular JIA. (Figure 1). Figure 1. We investigated the correlations between disease activity markers and plasma co-IRs. Plasma TIM3 levels correlated with erythrocyte sedimentation rate, C-reactive proteins and JADAS in the polyarticular JIA group. In oligoarticular JIA group, JADASs correlated with plasma PD-1 levels, C-reactive protein with PD-L1 plasma levels. Erythrocyte sedimentation rates correlated with IL-2, CD86, PD-L1 and PD-1 plasma levels. There was no correlation between disease activity markers and co-IRs levels in the systemic JIA group and enthesitis related arthritis group. Finally, we analysed the cellular surface expression of different co-IRs on the PBMCs of different JIA subtypes. Similar to plasma levels, both the percentage and the MFI (mean fluorescence intensity) of CTLA4 expression was higher in polyarticular JIA subgroup. Conclusion This is the first report studying the effects of different co-IRs in different subtypes of JIA. Polyarticular JIA patients had a different coIR profile, having more CTLA-4, PD-1 and 4-1BB in their plasma than the other subtypes of JIA References [1]Wedderburn, L.R., et al., Int Immunol, 2001. 13 (12): p. 1541-50. [2]Wherry, E.J. and M. Kurachi, Nat Rev Immunol, 2015. 15 (8): p. 486-99. Acknowledgements This work was supported by a research grant from FOREUM Foundation for Research in Rheumatology Disclosure of Interests None declared
New and Nonofficial Remedies
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Studies With Human Papilloma Virus Modeled After Known Papovavirus Systems&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1972)

Human papilloma virus should be a valuable model virus for the study of potential human oncogenic viruses. Studies based on known papovavirus systems and aimed at devising a susceptible tissue culture system are described. Specific antiserum was prepared in rabbits. About 109 papilloma virus particles/ml were needed to fix complement in the presence of the rabbit antibody. No virus hemagglutinin was detected. A variety of species of host cells, under various temperatures and nutrient supplementation, were surveyed for susceptibility to virus replication or transformation. All these attempts were negative. Similar experiments with papilloma virus DNA in the presence of diethylaminoethyl-dextran were also negative. However, the incorporation of radioactive precursor into DNA synthesized in cultures of human kidney cells was increased in the presence of virus particles. Representatives of major virus groups were used to detect a helper virus capable of complementing the growth of papilloma virus. Doubly infected cultures were monitored for papilloma virus antigen or particle formation. Various properties of each helper virus were analyzed for alterations attributable to papilloma virus. No helper or interfering interactions between papilloma virus and the heterologous viruses were detected. Papillomas were not produced in scarified weanling hamsters. No papilloma virus-induced antigens were noted in inoculated hamster cells based on in vivo transplantation rejection tests or antibody response.
Cause of Death in Very Old People
Authors: Robert R. Kohn
Journal: JAMA (1982)

According to the<i>Vital Statistics</i>, white women have a modal life span of 85 to 90 years, with most individuals dying at around the same age from either ischemic heart disease, cerebrovascular disease, pneumonia, or accidents, or at earlier ages from malignant neoplasms. White men die earlier than women, and nonwhite populations contain two or more subpopulations that die earlier than white populations. Major causes of death listed in<i>Vital Statistics</i>show similar patterns in the aged for all populations. A review of autopsy findings in 200 persons older than 85 years yielded a very different pattern. No acceptable cause of death, other than complications of the aging syndrome, was identified in at least 30% of the cases.<i>Vital Statistics</i>for the aged is misleading because diagnoses are not definitive. Physicians accept causes of death in the aged that would not be acceptable in younger persons, and the role of aging processes themselves as cause of death are not appreciated. Aging is characterized by a universal progressive decline in physiological function to the point where life cannot be maintained in the face of otherwise trivial tissue injury. It is proposed that senescence be viewed as a disease and be accepted as a cause of death. (<i>JAMA</i>1982;247:2793-2797)
Arteriosclerosis: A Survey of the Problem.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sensitivity of Leukemia Cell Lines to Cytotoxic Alkyl-Lysophospholipids in Relation to &lt;italic&gt;O&lt;/italic&gt;-Alkyl Cleavage Enzyme Activities
Authors: Clemens Unger, Hansjörg Eibl, Duck J. Kim, Edward A. Fleer, Jochen Kötting, Hans-H. Bartsch, Gerd A. Nagel, Klaus Pfizenmaier
Journal: JNCI Journal of the National Cancer Institute (1987)

The human leukemia cell lines K562, HL60, and Raji and the mouse leukemia cell line L1210 showed a differential susceptibility to the action of the alkyl-lysophospholipid (ALP) 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3). After 48 hours, the 50% growth-inhibition doses (ID50) of ET-18-OCH3 were found to be 0.78 μg/ml (HL60), 1.53 μg/ml (Raji), 4.41 μg/ml (K562), and 5.05 μg/ml (L1210), as determined by [3H]thymidine incorporation. At the same time, cell viability was determined by trypan blue exclusion and revealed median lethal doses (LD50) of 3.5 μg/ml (HL60), 15 μg/ml (Raji), 24 μg/ml (L1210), and 38 μg/ml (K562). Since O-alkyl cleavage enzyme previously was suggested as being important in the detoxification of cytotoxic ALPs, the enzyme activity was compared with the susceptibility to ET-18-OCH3 in the distinct cell lines. In comparison to an approximate sevenfold to elevenfold (ID50 and LD50, respectively) difference in the susceptibility of the above leukemia cell lines to ET-18-OCH3, no significant difference in the specific activities (0.13–0.21 nmol/min/mg) of the O-alkyl cleavage enzyme was found in the above leukemia cell lines. Therefore, the differential sensitivity of the cell lines investigated cannot be explained by differences in O-alkyl cleavage enzyme activity. Experiments with radiolabeled ET-18-OCH3 in Raji cells suggest, rather, a critical role for phospholipases C and/or D in ALP metabolism.
Urinary symptoms in general practice
Authors: M. Emslie
Journal: BMJ (1969)

The following summer, during the routine examination of school " leavers," a girl aged 15 years was seen with a rash of typical distribution thought to be scabies.She was asked, largely by chance, if there were any starlings' nests at her home, and she replied that the loft was full of them.A visit to the house confirmed that this was so, the birds having gained access to the loft through a missing tile in the roof.The loft communicated directly with the girl's bedroom by an open ventilator in the ceiling.Nesting material was collected, and the presence of Dermanyssus gallinae again confirmed.Similar measures to the loft and bedroom coincided with early and complete recovery of the patient.Though not perhaps common, it is of some importance to identify these creatures cor- rectly, since infestation may recur despite treatment, as it did in two of our patients, if nesting material is not destroyed.Spontaneous recovery, however, should normally occur if the source of the mites is removed.-We are, etc.,
Superior Vena Cava Syndrome due to Non—Small-cell Lung Cancer
Authors: Marc L. Citron
Journal: JAMA (1983)

Three patients with superior vena cava syndrome due to non-small-cell lung cancer were treated with chemotherapy alone. Symptomatic relief began within three days of treatment and substantial resolution of the syndrome occurred in all three patients. One patient had complete remission of tumor and the other two had more than a 50% tumor reduction within the first month of therapy. These are the first case reports indicating that combination chemotherapy may be effective as initial management of the superior vena cava syndrome due to non—small-cell lung cancer. (<i>JAMA</i>1983;250:71-72)
Editorial Board and Contents
Authors: Andrew Clark, Katja Brose, Fred Kop, Ria Otten, Patrick Scheffmann, Silvia Arber, Anders Björklund, Sweden Lund, Sarah Paul Bolam, Barry Dickson, Chris Doe, Craig Garner, Yukiko Goda, Kenneth Harris, Nancy Ip, Maria Karayiorgou, Robert Malenka, Mark Mattson, Freda Miller, Canada Richard, G Morris, Maiken Nedergaard, Eric Nestler, New York, Hitoshi Sakano, Greg Stuart, Marc Tessier-Lavigne
Journal: Trends in Neurosciences (2015)
Visual Loss Following Intranasal Corticosteroid Injection
Authors: Karla J. Johns
Journal: JAMA (1989)

Visual loss from embolization of the ocular circulation is a rare but devastating complication of injections into the cutaneous and mucocutaneous tissues of the face, scalp, and nasopharynx.<sup>1,2</sup>The mechanism seems to be inadvertent intra-arterial injection into the branches of the ethmoidal arteries, with retrograde flow into the ophthalmic artery. Even though the visual symptoms are transient in most cases, permanent visual loss has been reported.<sup>3,4</sup> A 37-year-old woman was treated with methylprednisolone acetate injections of the nasal turbinate for chronic allergic rhinitis. A few minutes after the injection, she became dizzy and described a sensation of seeing bright lights in the left eye, with blurring of vision. Examination revealed a best corrected visual acuity of 20/30 in the affected left eye, with 20/20 in the right eye. A paracentral scotoma was present on Amsler grid testing. Results of examination of the pupil and inspection of the anterior
Assessment and Screening of Older People: Needs Assessment for Older People
Authors: Irene J Higginson, Christina Victor
Journal: Journal of the Royal Society of Medicine (1994)

Assessments of need carried out so far have concentrated on single diseases or interventions rather than care groups or on people who have multiple pathologies. We therefore began a needs assessment for older people in a central London health authority. The health district--then called Parkside--covered 25 square miles in north London and had a resident population of 432,600 people, of which 7% were aged 75 years and over and 2% were aged 85 years and over. Estimates of the number of people with different disabilities and diseases were calculated using data from the General Household Survey, the office of Population Census Survey (OPCS) Disability Survey or other national or reliable surveys. Although the majority of older people were well--indicating a need for health promotion and disease prevention--we estimated the number of disabled older people in the district was in excess of 25,000, with the most common types of disability being those concerned with locomotion, hearing and personal care. Using data from the OPCS survey we were able to estimate there were 7328 people aged 75 years and over who were in the OPCS top five severity rating, which would mean that they probably required services. For mental health we estimated there would be approximately 6000 older people suffering from clinically significant depression, 6000 older people suffering from anxiety, and between 2740 and 4441 suffering moderate to severe dementia. A next step is to match an assessment of the prevalence of disease and disability, with an estimate of that being served locally.
Naloxone in Ethanol Intoxication
Authors: A.A.-B. BADAWY
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 May 1983Naloxone in Ethanol IntoxicationA.A.-B. BADAWY, M.D., M. EVANS, M.D.A.A.-B. BADAWY, M.D.Search for more papers by this author, M. EVANS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-5-672_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: An article (1) and a recent letter (2) have emphasized both the usefulness of naloxone in the treatment of acute alcohol intoxication and our poor understanding of how this opiate-receptor antagonist acts. One possible mechanism of action of naloxone is that of pharmacokinetic antagonism of acute alcohol intoxication. This is based on our findings (3) that intraperitoneal administration to rats of naloxone hydrochloride (1 mg/kg body weight) 1.5 hours after a similar injection of ethanol (2 g/kg body weight) causes, within 30 minutes, a decrease in blood ethanol concentration from 133 to 92 mg/ dL, and a...References1. LYONANTHONY LJ. Reversal of alcoholic coma by naloxone. Ann Inter Med. 1982;96:464-5. LinkGoogle Scholar2. GUERINFRIEDBERG JG. Naloxone and ethanol intoxication. Ann Intern Med. 1982;97:932. LinkGoogle Scholar3. BADAWYEVANS AM. The mechanism of the antagonism by naloxone of acute alcohol intoxication. Br J Pharmacol. 1981;74:514-6. CrossrefMedlineGoogle Scholar4. ALKANANOBLE RE. Amethystic agents—reversal of acute ethanol intoxication in humans. In: MAJCHROWICZ E, NOBLE EP, eds. Biochemistry and Pharmacology of Ethanol. New York: Plenum Press; 1979:349-74. CrossrefGoogle Scholar5. BADAWYEVANSPUNJANI AMN. Reversal by naloxone of the effects of chronic administration of drugs of dependence on rat liver and brain tryptophan metabolism. Br J Pharmacol. 1981;74:489-94. CrossrefMedlineGoogle Scholar6. BADAWYMORGAN AC. Tryptophan and tryptophan pyrrolase in haem regulation—the role of lipolysis and direct displacement of serum-protein-bound tryptophan in the opposite effects of administration of endotoxin, morphine, palmitate, salicylate and theophylline on rat liver 5-aminolaevulinate synthase activity and the haem saturation of tryptophan pyrrolase. Biochem J. 1982;206:451-60. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Whitchurch Hospital Cardiff CF4 7XB, Wales United Kingdom PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGastric emptying in the acutely inebriated patientAlcohol and Opiate DependenceAdvances in Clinical ToxicologyNaloxane and Alcohol IntoxicationJ. DUCOBU, M.D.Does naloxone always act as an opiate antagonist? 1 May 1983Volume 98, Issue 5_Part_1Page: 672-672KeywordsAlcoholismAttentionBloodBody weightEthanolIntoxicationPharmacokinetics Issue Published: 1 May 1983 PDF DownloadLoading ...
The Nasopharyngeal Culture in Acute Otitis Media
Authors: Richard Schwartz
Journal: JAMA (1979)

Simultaneous cultures of the nasopharynx and middle ear exudate (obtained by tympanocentesis) were obtained from 225 children (mean age, 34 months; median age, 41 months) with suppurative otitis media. A 72% prediction rate for middle ear pathogens was obtained by examining the nasopharyngeal cultures after the strict observance of two essential prerequisites: (1) the nasopharyngeal culture was immediately plated on appropriate solid agar and (2) a semiquantitative method for bacterial enumeration was employed in the reading of the nasopharyngeal culture plates. The technique was most valuable where 2+ (greater than 25% up to 50% of total number of colonies was a single pathogen) or greater of a single pathogen was recovered from the nasopharynx. In only one instance, the semiquantitative nasopharyngeal culture incorrectly predicted the middle ear pathogen if one was recovered. Quantitative nasopharyngeal cultures were particularly useful in predicting the presence of ampicillin-resistant<i>Haemophilus influenzae</i>and group A streptococci as causative agents in otitis media. (<i>JAMA</i>241:2170-2173, 1979)
Calcitonin Assay May Help Identify Burn Patients at Risk for Respiratory Distress
Authors: Andrew Skolnick
Journal: JAMA (1990)

AN ASSAY, which may provide a method for identifying burn patients who are at risk of developing respiratory distress syndrome, was described at the 72nd Annual Meeting of the Endocrine Society in Atlanta, Ga. The need for such a predictive capability is underscored by Kenneth L. Becker, MD, director of endocrinology at the Veterans Administration Center and at the George Washington University School of Medicine, Washington,
Gastrostomy and growth in dystrophic epidermolysis bullosa
Authors: L. HAYNES, D.J. ATHERTON, N. ADE-AJAYI, R. WHEELER, E.M. KIELY
Journal: British Journal of Dermatology (1996)

Journal Article Gastrostomy and growth in dystrophic epidermolysis bullosa Get access L. HAYNES, L. HAYNES Departments of Dermatology L.Haynes. Search for other works by this author on: Oxford Academic Google Scholar D.J. ATHERTON, D.J. ATHERTON Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar N. ADE‐AJAYI, N. ADE‐AJAYI Surgery Great Ormond Street Hospital for Children NHS Trust, London WC1N 3JH, U.K. Search for other works by this author on: Oxford Academic Google Scholar R. WHEELER, R. WHEELER Surgery Great Ormond Street Hospital for Children NHS Trust, London WC1N 3JH, U.K. Search for other works by this author on: Oxford Academic Google Scholar E.M. KIELY E.M. KIELY Surgery Great Ormond Street Hospital for Children NHS Trust, London WC1N 3JH, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 134, Issue 5, 1 May 1996, Pages 872–879, https://doi.org/10.1046/j.1365-2133.1996.120855.x Published: 01 May 1996 Article history Accepted: 06 September 1995 Published: 01 May 1996
Endoscopy International Open – recently published
Journal: Endoscopy (2017)

Comment on: Efficacy and safety of novel digital single-operator peroral cholangioscopy-guided laser lithotripsy for complicated biliary stones Endosc Int Open 2017; 05(01): E54-E58DOI: 10.1055/s-0042-118701 Comment on: Evaluation of the severity of ulcerative colitis using endoscopic dual red imaging targeting deep vesselsEndosc Int Open 2017; 05(01): E76-E82DOI: 10.1055/s-0042-119393 Comment on: Endoscopic treatment of leak at the tip of the “J” ileal pouchEndosc Int Open 2017; 05(01): E64-E66DOI: 10.1055/s-0042-121664
Rapid Resolution of Pulmonary Thromboemboli in Man
Authors: Herbert L. Fred
Journal: JAMA (1966)

Experimentally induced pulmonary thromboemboli in animals may undergo rapid, spontaneous resolution.<sup>1-5</sup>Little information is available, however, concerning the early fate of pulmonary thromboemboli in man. Sautter et al<sup>6</sup>described two patients with massive pulmonary thromboembolism in whom selective angiograms showed disappearance of the occlusive lesions within 25 and 128 days. Simon and Sasahara,<sup>7</sup>using the same technique, observed regression of filling defects in lobar arteries within eight weeks in one patient and complete clearing of multiple segmental obstructions within six weeks in another. Sabiston and Wagner,<sup>8</sup>using the method of radioisotope scanning in a patient with recurrent pulmonary thromboemboli, noted significant improvement in blood flow to the upper part of the right lung two months after the initial scan. In the study reported here, selective pulmonary arteriograms were performed serially to define more precisely the natural history of acute pulmonary thromboembolism in man. <h3>Material and Methods</h3>