tbuckley/cabot-search huggingface dataset:
Intracerebral Transplantation Into Rhesus Monkeys of Cell Cultures (NCLP-6) Derived From a Chemically Induced Primate Hepatocarcinoma&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1967)

Twenty-four rhesus monkeys (Macaca mulatta), varying in age from 1 day to approximately 4 years, were inoculated intracerebrally with cells from culture line NCLP-6 derived From a hepatocarcinoma induced in a rhesus monkey by N-nitrosodiethylamine. In 15 of the 24 monkeys, the brains showed no evidence of tumor growth. Five of the monkeys (4 newborns and 1 juvenile monkey 5 months old at the time of inoculation) showed progressive growth of the tumor to the time of death. The remaining 4 monkeys (1 newborn, 1 juvenile, and 2 monkeys 2-3 years of age at inoculation) showed evidence of tumor growth followed by necrosis, regression, and calcification of the transplant. In the monkeys inoculated as newborns, the incidence of positive transplants was higher, the latent period was shorter, and the tumors were larger than in the older monkeys. The histologic characteristics of the intracerebral transplants are described and illustrated. The actively growing tumors in the brain retained many of the morphologic features of the hepatocarcinoma from which the cell cultures were derived.
From the Food and Drug Administration
Authors: S. L. Nightingale
Journal: JAMA (1993)

The FDA has approved a supplemental new drug application for dronabinol for anorexia associated with weight loss in patients with acquired immunodeficiency syndrome (AIDS). The new indication is based on clinical studies involving patients with AIDS, in which the appetite-stimulation effect of dronabinol was sustained for up to 5 months. Dronabinol is manufactured by Unimed Inc, of Buffalo Grove, Ill, under the trade name Marinol. The drug is distributed by Roxane Laboratories Inc of Columbus, Ohio. Dronabinol is chemically synthesized Δ<sup>9</sup>-tetrahydrocannabinol, the principal active ingredient in marijuana. Dronabinol was approved initially in 1985 as an antiemetic for treatment of nausea and vomiting associated with cancer chemotherapy (<i>JAMA</i>. 1986;256:817). In January 1991, dronabinol was granted Orphan Drug status for appetite stimulation in patients with AIDS-related weight loss. Orphan Drug status entitles a sponsor to financial incentives for developing drug products for diseases or conditions affecting fewer than 200 000
Awards, Appointments, Announcements
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Awards, Appointments, Announcements Get access JNCI: Journal of the National Cancer Institute, Volume 86, Issue 9, 4 May 1994, Pages 667–668, https://doi.org/10.1093/jnci/86.9.667 Published: 04 May 1994
Highlights of This Issue
Journal: Clinical Cancer Research (2011)

Pancreatic cancers are resistant to most chemotherapeutic agents, and novel treatments are needed.Du and colleagues assessed the activity of an antimesothelin immunotoxin on pancreatic cancer cells and found that these cells are resistant to immunotoxin due to low levels of the proapoptotic protein Bak.Combining TRAIL or an anti-TRAIL receptor 2 antibody with immunotoxin caused synergistic cell death and reduced tumor volume in a xenograft mouse model.These data demonstrate that cancer cells with low BAK are resistant to immunotoxin treatment, and that combining immunotoxin with TRAIL or a TRAIL agonist antibody is an effective way to overcome such resistance.
Highlights of This Issue
Journal: Clinical Cancer Research (2014)

There exists uncertainty regarding optimal therapy combinations with inhibitors of vascular endothelial growth factor (VEGF) and its receptor (VEGFR). We assessed whether chemotherapy synergizes with VEGF/VEGFR (VEGF/R) inhibitors in a database of 1,498 patients with advanced solid malignancies treated on phase I protocols, 741 with VEGF/R inhibitors. Our analysis identified a synergistic interaction between concomitant chemotherapy and VEGF/R inhibitor use in producing clinical benefit on trial (defined as objective response or stable disease lasting at least 6 months). Specifically, we identified the antimetabolite chemotherapy class to exhibit the highest degree of synergy.Reolysin, the infusible form of reovirus, selectively enters malignant cells and is associated with clinical response when combined with chemotherapy. Sborov and colleagues present the first evidence of its use in hematologic malignancies and showed that the agent was well tolerated and associated with no dose-limiting toxicities in patients with relapsed multiple myeloma. Reovirus selectively entered myeloma cells, but only minimal viral replication and apoptosis was evident, suggesting that viral proliferation is necessary to induce clinically relevant antitumor activity. Further investigation will be necessary to elucidate the mechanisms of viral-mediated antitumor activity and identification of effective combination therapeutic strategies.Activation of the MET/HGF pathway has been associated with a range of tumor biology and has been shown to result in worse outcomes for patients. MET can be stimulated by HGF-dependent mechanisms or by HGF-independent mechanisms such as gene amplification, mutations, or transcriptional upregulation. Liu and colleagues describe the discovery and preclinical characterization of a bivalent MET antibody, LY2875358, which inhibits both HGF-dependent and HGF-independent MET activation but lacks functional agonist activity. The potent antitumor activity described by the authors supports the ongoing clinical evaluation of LY2875358 in patients with MET-activated tumors.AMACR promotes the β-oxidation of branched-chain fatty acids and is frequently overexpressed in common carcinomas, mostly through transactivation. Li and colleagues performed genomic profiling of myxofibrosarcomas and validated amplification of AMACR at 5p13.3 in 20% of myxofibrosarcomas that exhibited mRNA and protein overexpression with negative prognostic impact. In vitro and in vivo functional assays demonstrated that the oncogenic function of AMACR was linked to upregulated cyclin D1 and cyclin T2, hence promoting cell proliferation. Ebselen oxide, a nonsubstrate-based inhibitor of AMACR, enabled selective susceptibility in AMACR-expressing myxofibrosarcomas through induction of cellular apoptosis and proteasome-mediated degradation of AMACR protein.
Update: Influenza Activity—United States, 1995-96 Season
Journal: JAMA (1996)

In collaboration with the World Health Organization (WHO), its collaborating laboratories, and state and local health departments, CDC conducts surveillance to monitor influenza activity and to detect antigenic changes in the circulating strains of influenza viruses. This report summarizes influenza surveillance in the United States from September 28, 1997, through March 7, 1998, and presents reports of outbreaks in long-term care facilities (LTCFs) in three states and at a military base. The findings indicate that this season has been dominated by influenza A(H3N2) viruses and characterized by a sustained elevation in pneumonia and influenza (P&I)-related deaths.
Phantom Gallbladder
Authors: B AROSE, W W SHREEVE, R S BAIM, H L ATKINS
Journal: Clinical Nuclear Medicine (1987)

Nonvisualization of the gallbladder is the primary finding in cholescintigraphy for acute cholecystitis. Recent investigators have described a useful secondary finding of increased pericholecystic hepatic activity (PCHA). A case of acute cholecystitis is presented in which the PCHA was round in configuration and appeared in the first 5 minutes of the study. This may be a source of diagnostic error if it is interpreted as visualization of the normal gallbladder. Appearance of the PCHA has not been previously described before 30 minutes. This case of early appearance raises the possibility that hyperemia may play a role as the cause in some forms of the PCHA. The phantom gallbladder was correctly identified as PCHA by observing the peak of activity of the PCHA occurring before the appearance of intrahepatic biliary radicals.
Radioimmunoassay Detection of Hepatitis Type B Antigen
Authors: Gino L. Giorgini
Journal: JAMA (1972)

Of 161 recipients who received blood transfusions at the Providence, RI, Veteran's Administration Hospital, seven (4.3%) developed biochemical and/or histological evidence of viral hepatitis. Hepatitis type B antigen (HBAg) appeared in the sera from five of these patients during the course of their disease. One of these patients had received a unit of blood containing HBAg detected by counterimmunoelectrophoresis (CIE). The other four patients with HBAg-positive serum had received blood presumably negative for HBAg by CIE. However, subsequent studies using a sensitive double-antibody radioimmunoassay (RIA-DA) procedure revealed HBAg in ten of the 91 units administered to these four patients in which type B viral hepatitis had developed. Thus, donor blood negative for HBAg by the currently recommended CIE method may contain low HBAg concentrations detectable by RIA-DA which, when administered to recipients, can result in viral hepatitis type B.
Combination Heparin Plus Cortisone Treatment of Two Transplanted Tumors in C3H/He Mice
Authors: Penhaligon, Miranda, Camplejohn, Richard S.
Journal: JNCI Journal of the National Cancer Institute (1985)

Journal Article Combination Heparin Plus Cortisone Treatment of Two Transplanted Tumors in C3H/He Mice Get access Miranda Penhaligon, Miranda Penhaligon Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard S. Camplejohn Richard S. Camplejohn Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 74, Issue 4, April 1985, Pages 869–873, https://doi.org/10.1093/jnci/74.4.869 Published: 01 April 1985 Article history Received: 28 June 1984 Accepted: 21 November 1984 Published: 01 April 1985
Cancer Incidence in Humans: Relationship to Plasma Lipids and Relative Weight&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1982)

Surveillance was done on cancers in subjects in rural Iowa for 6 years after they participated in a cardiovascular risk factor-screening program. Among 5,565 men and women 20–94 years old at screening, 131 persons were identified as having cancers. Each cancer patient was matched to a control without cancer, and differences in antecedent plasma cholesterol and triglyceride levels and relative weight were sought. Mean relative weight at screening was lower among cancer patients of both sexes than among controls. Plasma cholesterol levels were lower among male patients and higher among female patients than among controls, with the differences more prominent for those less than 60 years old at screening. In males, the lower cholesterol levels occurred only in those with neoplasms developing within 24 months of screening. The higher cholesterol levels among female patients with cancers limited to gonadal hormone-related sites were not time-dependent. Triglyceride levels were not significantly different between cancer patients and controls in any analytic group, but triglyceride levels did closely parallel cholesterol alterations. A minimum of 1% of the cohort had diagnosed cancers before the screening program.
From the Congressional Office of Technology Assessment
Authors: D. R. Liskowsky
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Essentials of Experimental Physiology; for the Use of Students.
Journal: JAMA (1898)

made use of three different types : a small type employed in describing apparatus or the method of carrying out an experiment ; a medium type forming the main body of the text ; and a heavy type used in the accounts of the more fundamental experiments which are fitted for elementary classes.It seemed better to mark off these elementary experiments in this way rather than to separate the book into an elementary and an advanced course.,The number of elementary experiments given is only small, and a detailed list of them will be found on p. xiv.
Уміст вільних амінокислот сироватки крові у хворих із хронічним панкреатитом
Authors: V.I. Rusyn, Ye.S. Sirchak, N.Yu. Kurchak
Journal: GASTROENTEROLOGY (2013)

Наведено результати обстеження 48 хворих на хронічний панкреатит. Установлено дисбаланс вмісту вільних амінокислот сироватки крові із переважним зменшенням рівнів метіоніну (до (0,63 ± 0,10) мг%), триптофану (до (0,74 ± 0,15) мг%), лейцину та ізолейцину (до (0,41 ± 0,06) мг%). Амінокислотний дисбаланс у хворих із хронічним панкреатитом спричинює розвиток виражених клінічних проявів зовнішньосекреторної недостатності підшлункової залози.
1995 Homer W. Smith Award Lecture. Characterization of basolateral mTAL Cl- channels.
Authors: T E Andreoli
Journal: Journal of the American Society of Nephrology (1996)

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Ultrarare Coding Variants and Cognitive Function in Schizophrenia—Unraveling the Enduring Mysteries of Neuropsychiatric Genetics
Authors: David L. Braff, Tim B. Bigdeli
Journal: JAMA Psychiatry (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Awards, Appointments, Announcements
Journal: JNCI Journal of the National Cancer Institute (1992)

Awards, Appointments, Announcements Get access JNCI: Journal of the National Cancer Institute, Volume 84, Issue 18, 16 September 1992, Pages 1399–1401, https://doi.org/10.1093/jnci/84.18.1399 Published: 16 September 1992
Manual of Clinical Chemistry.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physician Recognition of the Signs and Symptoms of Secondary Syphilis
Authors: Thomas A. Chapel
Journal: JAMA (1981)

Thirty-four patients with secondary syphilis, seen in a public clinic for sexually transmitted diseases, had been examined previously by 36 community physicians. Secondary syphilis was the primary diagnosis by 14 (39.9%) of the 36 physicians and was included in the differential diagnosis by five others (13.9%). Twelve (33.3%) had not considered syphilis but did obtain a routine serological test that eventually led to the correct diagnosis. Five other physicians (13.9%) failed to include syphilis in the diagnosis and did not order serological tests. (<i>JAMA</i>1981;246:250-251)
Coronary Artery Surgery
Authors: Alan T. Marty
Journal: JAMA (1978)

Some descriptive simplifications— like the concept that patients with coronary disease have either single-, double-, or triple-vessel involvement—plainly distort reality. Nature, it seems, has created "coronary arteries as variable as fingerprints." This gap between conceptualization and reality raises an important question. How can we intelligently select patients for coronary surgery if each individual does not accurately fit into the categories we have so far defined and analyzed? To lift one corner of the verbal veil that has hid the answer, the authors start by altering our perception of coronary disease distribution. After discarding the standard diagram of coronary arteries (in favor of a handdrawn sketch of each patient's peculiar anatomy and pattern of disease), the authors present fascinating detail on all phases of bypass surgery: the clinical indications; angiography and its interpretation; preoperative education, evaluation, and preparation; informed consent; anesthetic and operative techniques; and postoperative management. Throughout, the discussion achieves
Reactive Oxygen Species: Their Relation to Pneumoconiosis and Carcinogenesis
Authors: Val Vallyathan, Xianglin Shi, Vincent Castranova
Journal: Environmental Health Perspectives (1998)

Occupational exposures to mineral particles cause pneumoconiosis and other diseases, including cancer.Recent studies have suggested that reactive oxygen species (ROS) may play a key role in the mechanisms of disease initiation and progression following exposure to these particles.ROS- induced primary stimuli result in the increased secretion of proinflammatory cytokines and other mediators, promoting events that appear to be important in the progression of cell injury and pulmonary disease.We have provided evidence supporting the hypothesis that inhalation of insoluble particles such as asbestos, agricultural dusts, coal, crystalline silica, and inorganic dust can be involved in facilitating multiple pathways for persistent generation of ROS, which may lead to a continuum of inflammation leading to progression of disease.This article briefly summarizes some of the recent findings from our laboratories with emphasis on the molecular events by which ROS are involved in promoting pneumoconiosis and carcinogenesis.
Place of Abdominoperineal Excision in Rectal Cancer
Authors: J Christiansen
Journal: Journal of the Royal Society of Medicine (1988)

In an attempt to elucidate if and when there is a place for abdominoperineal excision in rectal cancer, we have evaluated survival, risk of local recurrence and functional results of alternative procedures. There seems to be no difference in survival rate after intended curative surgery for rectal cancer between rectal excision and sphincter-saving resection. This is also true with respect to risk of local recurrence, except in patients with poorly differentiated Dukes' C tumours, where the risk of significant distal intramural spread is increased. Functional results are satisfactory after low anterior resection with colorectal anastomosis, whereas colo-anal anastomosis is followed by less satisfactory results especially in elderly patients. In these patients rectal excision with a permanent colostomy is probably preferable.
A Public Health Intervention Model for Work-Site Health Promotion
Authors: Steven N. Blair
Journal: JAMA (1986)

We need effective ways of getting adults to exercise if we are to meet the Surgeon General's 1990 health goals for the nation. This study reports a comprehensive effort to evaluate the sustained effect of a public health intervention model to achieve these health goals. Employees at four companies (N=2,600) were exposed to a health promotion program, while employees at three comparison companies (N=1,700) were offered an annual health screen. Daily energy expenditure in vigorous activity increased 104% among employees at companies offering the health promotion program, compared with a 33% increase among employees at comparison companies. Changes in exercise habits were corroborated by estimates of maximal oxygen uptake. Exercise and physical fitness improvements were distributed throughout the work force. Meaningful population changes in exercise and physical fitness can be produced at the work site and are of a magnitude that makes it possible to meet the 1990 goals for exercise and physical fitness. (<i>JAMA</i>1986;255:921-926)