POS0525 WORSENING BURDEN OF GOUT AMONG ASIAN AMERICAN ADULTS – GENERAL POPULATION-BASED STUDY (2011-2018)
Authors: C. Yokose, N. Mccormick, N. Lu, S. Tanikella, K. Lin, A. Joshi, L. Raffield, E. Warner, T. Merriman, J. Hsu, K. Saag, Y. Zhang, H. Choi
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Asian Americans are the fastest-growing racial/ethnic group in the US. Gout disparities in Black Americans have been explained by socio-clinical factors; however, no data are available among Asians living in Western countries, despite their disproportionately worsening metabolic health. <h3>Objectives</h3> To determine the prevalence of gout and serum urate concentrations according to race/ethnicity and the potential impact of social determinants of health and clinical factors. <h3>Methods</h3> Using data from the latest NHANES cycles (2011-2018) in which Asian race data were collected, we determined the prevalence of gout and serum urate concentrations according to race/ethnicity and the potential impact of social determinants of health and clinical factors. We sought to replicate the Asian-White differences in the UK Biobank. <h3>Results</h3> Gout now affects 12.1 million Americans, with its prevalence increasing from 3.6% (95% CI, 2.8, 4.5) in 2011-2012 to 5.1% (4.2, 5.9) in 2017-2018 (p-trend=0.03); this trend nullified after excluding Asians (p-trend, 0.11) or after age adjustment (p-trend, 0.06). During the same period, age- and sex-adjusted prevalence among Asian Americans doubled from 3.3% to 6.6% (p-trend=0.007) to exceed all other racial/ethnic groups in 2017-2018 (<b>Figure 1</b>), with age- and sex-adjusted odds ratio (OR; Asian vs. White) of 1.61 (1.03, 2.51) and socio-clinical-factor-adjusted multivariable OR of 2.62 (1.59, 4.33) (<b>Table 1</b>). The latest gout prevalence among Americans ≥65 years was 10.0% among Whites and 14.8% among Asians (including 23.6% of Asian men). Serum urate concentrations also increased between 2011-2018 among Asian Americans (p-trend=0.009). The Asian-White disparity was also present in the UK Biobank (<b>Table 1</b>). <h3>Conclusion</h3> Gout now affects &gt;12 million US adults due to an aging population and rising prevalence among Asian Americans, which surpassed all other racial/ethnic groups in 2017-2018. This Asian-White disparity does not appear to be driven by socio-clinical factors. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> Chio Yokose: None declared, Natalie McCormick: None declared, Na Lu: None declared, Sruthi Tanikella: None declared, Kehuan Lin: None declared, Amit Joshi Employee of: Employed by Regeneron Pharmaceuticals, Laura Raffield: None declared, Erica Warner: None declared, Tony Merriman: None declared, John Hsu: None declared, Kenneth Saag Consultant of: Consulting fees from Abbvie, Amgen, Arthrosi, Atom Bioscience, Bayer, CSSL Behring, Daiichi Sankyo, Gilead, Horizon, Inflamzone, LG, Mallinckrodt, Radius, Roche/Genentech, SOBI, Shanton, and Takeda., Grant/research support from: Research support from Amgen, Takeda, Horizon, Mallinckrodt, SOBI, and Radius., Yuqing Zhang: None declared, Hyon Choi Consultant of: Ironwood, Selecta, Horizon, Takeda, Kowa, and Vaxart, Grant/research support from: Research support from Ironwood and Horizon.