AB0699 IS AUTONOMIC DYSFUNCTION MORE COMMON IN PATIENTS WITH PRIMARY SJÖGREN’S SYNDROME WITH FIBROMYALGIA THAN IN PATIENTS WITHOUT FIBROMYALGIA?
Authors: D. Karatas, N. Erdik, G. Yavuzbilge, S. B. Acikgoz, S. M. Türk, C. Arslantürk Güneysu, Z. Öztürk, E. Gönüllü
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Primary Sjögren's syndrome (pSS) is an autoimmune disease that primarily affects the exocrine glands, but other organs, including the nervous system, may also be affected [1]. Many studies provide evidence of autonomic dysfunction in pSS [2,3]. Although the etiology of fibromyalgia (FM) is not fully understood, data suggest that FM may be caused by autonomic nervous system dysfunction [4]. <h3>Objectives</h3> In this study, we aimed to reveal the incidence of autonomic dysfunction in patients with pSS compared to those without fibromyalgia. <h3>Methods</h3> In this cross-sectional study, 64 patients who admitted to our Sakarya University Faculty of Medicine rheumatology outpatient clinic between November 2021 and August 2022 and were followed up with the diagnosis of pSS were included. The patients were divided into two groups 35 (54.7%) with fibromyalgia and 29 (45.3%) without fibromyalgia. Patients were evaluated with the Composite Autonomic Symptom Score-31 (COMPASS-31), which consists of 6 subsections including autonomic dysfunction, orthostatic, vasomotor, secretomotor, gastrointestinal, bladder and pupillomotor functions. Mann-Whitney U test and Chi-square test were used to compare the groups. <h3>Results</h3> The mean age of the patients was 53.8±11.3 years. There was no difference between the groups regarding sex and age (p = 0.586 and p = 0.580, respectively). The median disease duration (IQR) was 4(5) years. The mean total COMPASS-31 score was significantly higher in patients with fibromyalgia than in those without fibromyalgia (0.014). Among its subgroups, secretory dysfunction was significantly higher in patients with fibromyalgia (p=0.001). Vasomotor dysfunction is more common in patients with FM (p=0.016) (Table 1). <h3>Conclusion</h3> In our study, patients with pSS with fibromyalgia had a higher COMPASS-31 score than those without FM, and especially the secretory dysfunction score was higher. Since both diseases can cause autonomic dysfunction separately, it seems reasonable to have a high total COMPASS-31 score in patients with both. In addition, vasomotor dysfunction is more common in patients with FM. <h3>References</h3> [1]Bowman S, Hamburger J, Price E, Rauz S. Oxford Textbook of Rheumatology. Sjögren's Syndrome—Clinical Features. Oxford, UK: Oxford University Press; (2018). [Google Scholar] [2]Newton JL, Frith J, Powell D, Hackett K, Wilton K, Bowman S, et al.. Autonomic Symptoms are Common and Are Associated With Overall Symptom Burden and Disease Activity in Primary Sjogren's Syndrome. Ann Rheum Dis (2012) 71(12):1973–9. 10.1136/annrheumdis-2011-201009 [3]Koh JH, Kwok S-K, Lee J, Park S-H. Autonomic Dysfunction in Primary Sjogren's Syndrome: A Prospective Cohort Analysis of 154 Korean Patients. Korean J Intern Med (2017) 32(1):165–73. 10.3904/kjim.2015.219 [4]da Cunha Ribeiro RP, Roschel H, Artioli GG, Dassouki T, Perandini LA, Calich AL, de Sá Pinto AL, Lima FR, Bonfá E, Gualano B. Cardiac autonomic impairment and chronotropic incompetence in fibromyalgia. Arthritis Res Ther. 2011;13:R190. doi: 10.1186/ar3519. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.