tbuckley/cabot-search huggingface dataset:
Dominant neoantigen verification in hepatocellular carcinoma by a single-plasmid system coexpressing patient HLA and antigen
Authors: Pu Chen, Dongbo Chen, Dechao Bu, Jie Gao, Wanying Qin, Kangjian Deng, Liying Ren, Shaoping She, Wentao Xu, Yao Yang, Xingwang Xie, Weijia Liao, Hongsong Chen
Journal: Journal for ImmunoTherapy of Cancer (2023)

Background Previous studies confirmed that most neoantigens predicted by algorithms do not work in clinical practice, and experimental validations remain indispensable for confirming immunogenic neoantigens. In this study, we identified the potential neoantigens with tetramer staining, and established the Co-HA system, a single-plasmid system coexpressing patient human leukocyte antigen (HLA) and antigen, to detect the immunogenicity of neoantigens and verify new dominant hepatocellular carcinoma (HCC) neoantigens. Methods First, we enrolled 14 patients with HCC for next-generation sequencing for variation calling and predicting potential neoantigens. Then, the Co-HA system was established. To test the feasibility of the system, we constructed target cells coexpressing HLA-A*11:01 and the reported KRAS G12D neoantigen as well as specific T-cell receptor (TCR)-T cells. The specific cytotoxicity generated by this neoantigen was shown using the Co-HA system. Moreover, potential HCC-dominant neoantigens were screened out by tetramer staining and validated by the Co-HA system using methods including flow cytometry, enzyme-linked immunospot assay and ELISA. Finally, antitumor test in mouse mode and TCR sequencing were performed to further evaluate the dominant neoantigen. Results First, 2875 somatic mutations in 14 patients with HCC were identified. The main base substitutions were C&gt;T/G&gt;A transitions, and the main mutational signatures were 4, 1 and 16. The high-frequency mutated genes included HMCN1 , TTN and TP53 . Then, 541 potential neoantigens were predicted. Importantly, 19 of the 23 potential neoantigens in tumor tissues also existed in portal vein tumor thrombi. Moreover, 37 predicted neoantigens restricted by HLA-A*11:01, HLA-A*24:02 or HLA-A*02:01 were performed by tetramer staining to screen out potential HCC-dominant neoantigens. HLA-A*24:02-restricted epitope 5'-FYAFSCYYDL-3' and HLA-A*02:01-restricted epitope 5'-WVWCMSPTI-3' demonstrated strong immunogenicity in HCC, as verified by the Co-HA system. Finally, the antitumor efficacy of 5'-FYAFSCYYDL-3'-specific T cells was verified in the B-NDG- B2m tm1 Fcrn tm1(mB2m) mouse and their specific TCRs were successfully identified. Conclusion We found the dominant neoantigens with high immunogenicity in HCC, which were verified with the Co-HA system.
Accent on Communication
Authors: Pedro A. Poma
Journal: JAMA (1985)

With all patients, good communication is important and requires translation from medical "lingo" to clear language the patient understands. Communication becomes even more complicated when dealing with patients for whom English is not the native language. However, just as we have a responsibility to try to communicate with young children, or with adults who are deaf or who have a speech impediment, we also have the responsibility to try to communicate with persons who do not speak English. All persons under the stress of illness need sympathy and warmth. Even when one masters English as a second language, the native tongue remains the language of intimacy and closeness. Although speaking English may be considered more professional, its use with a person for whom English is a second language makes the exchange more detached, sterile, and cold. During stress or exhaustion, while waking up and falling asleep, and when dying, one
Rochalimaea Infections
Authors: Lucy S. Tompkins
Journal: JAMA (1994)

<i>Rochalimaea</i>are gram-negative bacteria that are recently discovered agents of new clinical syndromes, including bacillary angiomatosis (BA) and bacillary peliosis hepatis, and two well-known diseases, cat scratch disease (CSD) and trench fever. Trench fever, first described as an epidemic infection in World War I, was attributed to louse-borne<i>Rochalimaea quintana</i>infections, which were thought to be quite rare in the United States.<i>Rochalimaea henselae</i>is a newly described member of the genus,<sup>1</sup>very closely related to<i>R quintana</i>, and was first shown to be a causative agent of BA,<sup>2</sup>peliosis hepatis,<sup>3,4</sup>and a febrile bacteremia syndrome<sup>5</sup>in 1990. Recent studies have also demonstrated that<i>R quintana</i>infection can also produce BA in patients who have tested positive for the human immunodeficiency virus.<sup>6</sup><i>Rochalimaea henselae</i>may also cause a syndrome resembling trench fever in immunocompetent individuals exposed to tick bites,<sup>7</sup>and a few patients without
Gun Violence Affects More Than Half of US Adults
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FDA Approves Vilobelimab for Emergency Use in Hospitalized Adults
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Guideline Update
Authors: Nigel S. Key, Alok A. Khorana, Nicole M. Kuderer, Kari Bohlke, Agnes Y.Y. Lee, Juan I. Arcelus, Sandra L. Wong, Edward P. Balaban, Christopher R. Flowers, Leigh E. Gates, Ajay K. Kakkar, Margaret A. Tempero, Shilpi Gupta, Gary H. Lyman, Anna Falanga
Journal: Journal of Clinical Oncology (2023)

To conduct an update of the ASCO venous thromboembolism (VTE) guideline.After publication of potentially practice-changing clinical trials, identified through ASCO's signals approach to updating, an updated systematic review was performed for two guideline questions: perioperative thromboprophylaxis and treatment of VTE. PubMed and the Cochrane Library were searched for randomized controlled trials (RCTs) published between November 1, 2018, and June 6, 2022.Five RCTs provided information that contributed to changes to the 2019 recommendations. Two RCTs addressed direct factor Xa inhibitors (either rivaroxaban or apixaban) for extended thromboprophylaxis after surgery. Each of these postoperative trials had important limitations but suggested that these two oral anticoagulants are safe and effective in the settings studied. An additional three RCTs addressed apixaban in the setting of VTE treatment. Apixaban was effective in reducing the risk of recurrent VTE, with a low risk of major bleeding.Apixaban and rivaroxaban were added as options for extended pharmacologic thromboprophylaxis after cancer surgery, with a weak strength of recommendation. Apixaban was also added as an option for the treatment of VTE, with high quality of evidence and a strong recommendation.Additional information is available at www.asco.org/supportive-care-guidelines.
Beverage consumption and mortality among adults with type 2 diabetes: prospective cohort study
Authors: Le Ma, Yang Hu, Derrick J Alperet, Gang Liu, Vasanti Malik, JoAnn E Manson, Eric B Rimm, Frank B Hu, Qi Sun
Journal: BMJ (2023)

To investigate the intake of specific types of beverages in relation to mortality and cardiovascular disease (CVD) outcomes among adults with type 2 diabetes.
Management of Anxiety and Depression in Adult Survivors of Cancer: ASCO Guideline Update
Authors: Barbara L. Andersen, Christina Lacchetti, Kimlin Ashing, Jonathan S. Berek, Barry S. Berman, Sage Bolte, Don S. Dizon, Barbara Given, Larissa Nekhlyudov, William Pirl, Annette L. Stanton, Julia H. Rowland
Journal: Journal of Clinical Oncology (2023)

To update the American Society of Clinical Oncology guideline on the management of anxiety and depression in adult cancer survivors.A multidisciplinary expert panel convened to update the guideline. A systematic review of evidence published from 2013-2021 was conducted.The evidence base consisted of 17 systematic reviews ± meta analyses (nine for psychosocial interventions, four for physical exercise, three for mindfulness-based stress reduction [MBSR], and one for pharmacologic interventions), and an additional 44 randomized controlled trials. Psychological, educational, and psychosocial interventions led to improvements in depression and anxiety. Evidence for pharmacologic management of depression and anxiety in cancer survivors was inconsistent. The lack of inclusion of survivors from minoritized groups was noted and identified as an important consideration to provide high-quality care for ethnic minority populations.It is recommended to use a stepped-care model, that is, provide the most effective and least resource-intensive intervention based on symptom severity. All oncology patients should be offered education regarding depression and anxiety. For patients with moderate symptoms of depression, clinicians should offer cognitive behavior therapy (CBT), behavioral activation (BA), MBSR, structured physical activity, or empirically supported psychosocial interventions. For patients with moderate symptoms of anxiety, clinicians should offer CBT, BA, structured physical activity, acceptance and commitment therapy, or psychosocial interventions. For patients with severe symptoms of depression or anxiety, clinicians should offer cognitive therapy, BA, CBT, MBSR, or interpersonal therapy. Treating clinicians may offer a pharmacologic regimen for depression or anxiety for patients who do not have access to first-line treatment, prefer pharmacotherapy, have previously responded well to pharmacotherapy, or have not improved following first-line psychological or behavioral management.Additional information is available at www.asco.org/survivorship-guidelines.
Rescue of glutaric aciduria type I in mice by liver-directed therapies
Authors: Mercedes Barzi, Collin G. Johnson, Tong Chen, Ramona M. Rodriguiz, Madeline Hemmingsen, Trevor J. Gonzalez, Alan Rosales, James Beasley, Cheryl K. Peck, Yunhan Ma, Ashlee R. Stiles, Timothy C. Wood, Raquel Maeso-Diaz, Anna Mae Diehl, Sarah P. Young, Jeffrey I. Everitt, William C. Wetsel, William R. Lagor, Beatrice Bissig-Choisat, Aravind Asokan, Areeg El-Gharbawy, Karl-Dimiter Bissig
Journal: Science Translational Medicine (2023)

Glutaric aciduria type I (GA-1) is an inborn error of metabolism with a severe neurological phenotype caused by the deficiency of glutaryl-coenzyme A dehydrogenase (GCDH), the last enzyme of lysine catabolism. Current literature suggests that toxic catabolites in the brain are produced locally and do not cross the blood-brain barrier. In a series of experiments using knockout mice of the lysine catabolic pathway and liver cell transplantation, we uncovered that toxic GA-1 catabolites in the brain originated from the liver. Moreover, the characteristic brain and lethal phenotype of the GA-1 mouse model was rescued by two different liver-directed gene therapy approaches: Using an adeno-associated virus, we replaced the defective Gcdh gene or we prevented flux through the lysine degradation pathway by CRISPR deletion of the aminoadipate-semialdehyde synthase (Aass) gene. Our findings question the current pathophysiological understanding of GA-1 and reveal a targeted therapy for this devastating disorder.
Study: No More Than 6 Teaspoons of Added Sugar per Day
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rule Tackles Medicare Advantage Marketing, Prior Authorization
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
How Parents’ Views Are Tied to Children’s COVID-19 Vaccination
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Generalized Pustular Psoriasis Physician Global Assessment (GPPGA) score: online assessment and validation study of a specific measure of GPP disease activity
Authors: A David Burden, Hervé Bachelez, Siew Eng Choon, Slaheddine Marrakchi, Tsen-Fang Tsai, Hamida Turki, Akimichi Morita, Mark G Lebwohl, Robert Bissonnette, Min Zheng, Milan J Anadkat, Alexander A Navarini, Ming Tang, Christian Thoma, Kristina Callis Duffin
Journal: British Journal of Dermatology (2023)

Generalized pustular psoriasis (GPP), a rare and potentially life-threatening neutrophilic skin disease, is characterized by recurrent flares of pustulation on nonacral skin with associated erythema, crusting and scaling. There are no agreed or validated measurements for assessing GPP severity or symptom improvement; clinically validated endpoints that incorporate key manifestations of GPP, and are meaningful and reliable for the evaluation of treatment response, are needed.
RSV Infection Might Be Resuming Prepandemic Patterns
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early surgery for sciatica
Authors: Annina B Schmid, Lucy Dove, Lucy Ridgway, Christine Price
Journal: BMJ (2023)

International guidelines for sciatica recommend a stepped care approach starting with conservative management (ie, physiotherapy and medication), escalating to steroid injections, then surgery when non-surgical treatment has failed or when major radicular weakness is present. 1 Unfortunately, evidence on the effectiveness of both non-surgical 2 -5 and surgical options is uncertain.In a linked paper, 6 Liu and colleagues (doi:10.1136/bmj
Exposure to Cotton Dust and Respiratory Disease
Authors: Siegfried Heyden
Journal: JAMA (1980)

GENERAL agreement exists that some persons experience an acute respiratory reaction when exposed to cotton dust. Symptoms range from coughing and wheezing to shortness of breath and chest tightness and can occur and subside intermittently. Thus, the variability of symptoms among susceptible persons appears characteristic of the condition called byssinosis. It is further recognized that a certain number of workers will experience bronchitis when continually exposed to substantial cotton dust levels over a long period. There is, however, a vast difference of opinion regarding the production of chronic obstructive lung disease to cotton dust. Many experts question whether a disabling disease develops from long-term cotton dust inhalation and do not accept a cause-and-effect relationship between cotton dust and chronic obstructive lung disease. They base their opinion on several studies, some of which will be discussed here. A group<sup>1</sup>from Duke University made two particularly striking observations that have received
John Wolcot, MD (1738-1819)
Authors: William B. Ober
Journal: JAMA (1969)

Alexandert the "life of L a Wit is a warfare upon earth." Few better examples could be found to illustrate Pope's semiautobiographical remark than the life of John Wolcot (1738-1819), who started his professional life as a physician, had a brief inglorious fling at being a clergyman, returned to the practice of medicine, and finally abandoned it for the life of a satirist. He wrote under the pseudonym of Peter Pindar, and his satires on art, literature, and politics dominated English satire from 1782, much as James Gillray's caricatures were preeminent during the same period. The true goal of satire, according to Dryden, is "the amendment of Vices by correction," or as Defoe phrased it, "The end of satyr is reformation." Satire, or at least social protest, was not new to English poetry; literary historians can trace its presence back before Chaucer, but it remained for Donne, Marston, and Hall
Successful Reconstitution of Human Hematopoiesis in the SCID-hu Mouse by Genetically Modified, Highly Enriched Progenitors Isolated From Fetal Liver
Authors: Laurent Humeau, Christian Chabannon, Meri T. Firpo, Patrice Mannoni, Claude Bagnis, Maria-Grazia Roncarolo, Reiko Namikawa
Journal: Blood (1997)