Safety, Immunogenicity, and Efficacy of the NVX-CoV2373 COVID-19 Vaccine in Adolescents
Authors: Germán Áñez, Lisa M. Dunkle, Cynthia L. Gay, Karen L. Kotloff, Jeffrey M. Adelglass, Brandon Essink, James D. Campbell, Shane Cloney-Clark, Mingzhu Zhu, Joyce S. Plested, Pavitra Roychoudhury, Alexander L. Greninger, Nita Patel, Alice McGarry, Wayne Woo, Iksung Cho, Gregory M. Glenn, Filip Dubovsky, James Andersen, Szheckera Fearon, Rosa Negron, Amy Medina, Colleen Figueroa, Courtney Smith, Bruce Rankin, John M. Hill, Steven Shinn, Vivek Rajasekhar, Marshall Nash, Ashraf Affan, Armando Acevedo, Alina Monteagudo Can, Hector Rodriguez, Israel Zagales, Christine Prieto, Lizz Hernandez Diaz, Max Hale, Patrick Farr, Liesel French, Teresa Goldsmith, James Warmack, Bailey Murphy, Robyn Hartvickson, Brooke Dunlavy, Richard Glover, Amber Grant, Troy Holderman, Stacy Slechta, Terry Poling, Terry Klein, Thomas Klein, Tracy Klein, Sarah Pinkham, Shannen Lassiter, Imad Jandali, Maryam Belavilas, David Daniels, Katie Leonard, Abigail Vetter, Toni Rich, Samir Arora, Grazia Cannon, Sridhar Guduri, Alandra Lingel, Veronica Moore, Sarah Wilcox, Richard Gorman, Gary Horwith, Robin Mason, Laurence Chu, Michelle Listz, Lamar Box, Cindy Duran, Isaiah Knight, Katherine Davis, William Seger, John Villegas, Ben Seger, Virginia Loudermilk, Ruth Reyes, Anthony Kim, Wendy C Daly, Rebecca Becherer, Denver Cornett, Karen Dick, Kimberly Downs, Pamela Hall, Donald M. Brandon, William B. Davis, Daniel T. Lawler, Cindy Stevens, Karl Walter, Michelle Rios, Howard Schwartz, Nelia Sanchez-Crespo, Thelma Beltron, Jennifer Schwartz, Patricia Balebona, Beatriz Rivera, Barbara Garcia, Christine B. Turley, Andrew McWilliams, Tiffany Esinhart, Natasha Montoya, Shamika Huskey, Leena Paul, Michael E. Dever, Mitul Shah, Michael Delgado, Tameika Scott Scott, Patricia Brown, Americo Padilla, Lisa S. Usdan, Lora J. McGill, Valerie K. Arnold, Carolyn Scatamacchia, Codi Anthony, Robyn Presley, Stephan Sharp, Michael Caldwell, Linda Schipani, Allison Ulrich, Wendy Tidwell, Stacy Lynn Cox, Michael Levin, Julia Gass, Marcy Kulic, Eduardo Rodriguez, Jessica Corea, Sierra Dansbee, John Delgado, Jaleh Ostovar, Audrey Kuehl, Sarah Smiley, Danuel Hamlin, Ben Taucher, Cayce Tangeman, Yvonne Davis, Vanessa Armetta, Mary Love, David Summers, J. Bruce Etheridge, Teresita Salazar, Femina David, Filipinas Vitug, Amiel Guevarra, Noemi Ramirez, Ronald Ackerman, Jamie Ackerman, Florida Aristy, Lawrence Corey, Kathleen M Neuzil, Huub G Gelderblom, Nzeera Ketter, Carrie Sopher, Vicki E. Miller, Amy Starr, Sonia Guerrero, Madiha Baig, Maryam Jamil, Husain Motiwala, Khozema Palanpurwala, Monica Murry, Amy Starr, MD, Starr, Meghan Tonti, Rebecca Wischnewsky, Earl Martin, Yogesh K. Paliwal, Amit Paliwal, Sarah Gordon, Krystle Edwards, Cynthia Montano-Pereira, Michael Campos, George H. Freeman, Esther Laverne Harmon, Marshall A. Cross, Kacie Sales, Catherine Q. Gular, Joseph Ley, Amanda Donoho, Kimberley Hunt, Donald Lewis, Stephanie Tipton, Emily Whitaker, Jeffry Jacqmein, Maggie Bowers, Dawn Robison, Victoria Mosteller, Janet Garvey, Carlos Fierro, Mary Easley, Amy Thompson, MD, Thompson, Heather Barker, Mazen Zari, Karol Moore, Daniel Finn, Lindsay Blackman, Stanley Block, Christal Denton, Martha Osborn, Robert Smith, Carl P. Griffin, William Schnitz, Raymond Cornelison, Linda Lopez, Kim Hamilton, Kim Calloway, David B. Musante, William P. Silver, Linda R. Belhorn, Nicholas A. Viens, David Dellaero, Elizabeth Wilkers, Robert Jeanfreau, Nicki Johnson, Estafania Bazan, Davilyn Roys, Steven Darden, Susan Jeanfreau, Paul G. Matherne, Amy Caldwell, Jessica Stahl, Nicole Guttierrez, Cassandra Beeks, Frank Eder, Ryan Little, Susan Owen, Heather Shaw, John Tarbox, Victoia Engler, Roni Gray, Fritz Raiser, Christine Wilson, Tiffany Nemecek, Hannah Harrington, Charles Harper, Torie Johnson, Chelsie Nutsch, Sally Eppenbach, Wendell Lewis, Katlyn Mace, Brannon C Perilloux, Christopher Dedon, Lori Cook, Zedlitz Zedlitz, Vasavi Srinivasan, Paige Melner, Joanna Sextor, Jessica Long, Francis Palumbo, Devon Myers, Caroline Vleck, Peter Warfield, Tatiana Beresnev, Maryam Jahromi, Mary A. Marovich, Julia Hutter, Martha Nason, Mark Leibowitz, Fernanda Morales, Mike Delgado, Rosario Sanchez, Norma Vega, Gary Albert, Erin Coston, Chinar Desai, Haoua Dunbar, Mark Eickhoff, Renee Entzminger-Sneed, Jenina Garcia, Margaret Kautz, Angela Lee, Maggie Lewis, Patrick Newingham, Patty Price-Abbott, Patty Reed, Kimberly Cerenze Short, Diana Vegas, Bethanie Wilkinson, Katherine Smith, David L. Fried, Lynne A. Haughey, Ariana C. Stanton, Monica Freeman, Jacqueline DiFazio, Courtney Langlois, Rosario Retino, Alexis Deniz, Wendy Paiva, Leonel Pajarillaga, Lisa Pyio, Lendy Torres, Paul Wisman, Carlos Armengol, Gemia Bouber, Peggy Bressler, Alaina Brown, Candyce Dorsey, Bernard Grunstra, Amy Dye, Dye, Shelby Gilmer Olds, Joshua Bullen, Miranda Roark, Jennie Eller, Elizabeth Barranco-Santana, Jessica Rodriguez, Rafael Mendoza, Karen Ruperto, Odette Olivieri, Enrique Ocaña, Bryce Palchick, Nathan Bennett, Sarah Sobrosky, Michael Gates, Suzanne Klutch, Jessica Martier, Marilou Cruz, Hoang-Chuing Vu, Janet Serrano, Valerie Martinez, Marc Cruz, Teresa S. Sligh, Parul Desai, Vincent Huynh, Carlos Lopez, Erika Mendoza, Waseem Chughtai, Anuja Sathe, Pamela Fox, Matthew G. Davis, Jennifer Foley, Shelly Kane, Cassidy Glod, Marissa Wuilliez, Abigail Purcell, Shelly Senders, Ashley Jeffrey, Christopher Fackelmann, Nicholas Jezerinc, Caitlin Fillioe, Timothy Hudec, Charles Fogarty, Nicole Crockford, Jami Jones, Connie Mccauley, Sherry Yeisley, Alison Fogarty, Douglas Logan, Bruce C. Gebhardt, Padma N. Mangu, Debra Beck Schroeck, Rajesh Kumar Davit, Gayle D. Hennekes, Larkin Tyler Wadsworth, Horacio Marafioti, Lyly Dang, Lauren Clement, Jennifer Berry, Adebayo Akinsola, Gabriela Baetista, Baba Arimah, Sheree Dover, Leslie Hernandez, Susan Herrera, Kenneth Etokhana, Nathaniel De La Cruz, Xavier Fajardo, Veronica Galaviz, Meranda Ruiz, Tony Diaz, Veronica Garcia-Fragoso, Maria Gabriela Becerra, Cecilia Mckeown, Lisa Holloway, Stacey Montero, Tracy Kowalsi, Stuart H. Cohen, Monica Ruiz, Dean M. Boswell, Elizabeth E. Robison, Trina L. Reynolds, Sonja Neumeister, Thomas B. Campbell, Suzanne Fiorillo, Rebecca Pitotti, Victoria Riedel Anderson, Jose Castillo Mancilla, Nga Le, Milagritos Tapia, Kathleen Neuzil, Andrea Berry, E. Adrienne Hammershaimb, Rosa MacBryde, Diana F Florescu, Richard Starlin, David Kline, Andrea Zimmer, Anum Abbas, Natasha Wilson, Erin Hoffman, Carolina Pastrana Medina, Susan Pedersen, Mandy Tipton, Alison Burbank, Michelle Hernandez, Peyton Thompson, Zachary Willis, Joseph Eron, Robert W. Coombs, Erin A. Goecker, Yunda Huang, Youyi Fong, Robert J. Buynak, Angella Webb, Rena Rivas, Stephanie Andree, Rachel McNeal, Megan Smith, Julie Kasarjian, Judith Kirstein, Krista Foster, Nicole Abels, Brandy Lopez, Crystle Rajania, Margaret Rhee, Gabrielle Jones, Alanna Billups, Jane Boggan, Denise Roadman, Celeste Blazy, Marian E. Shaw, Mark A. Turner, Cory J. Huffine, Esther S. Huffine, Raymond Coon, Jacqueline Hanson, Michael Waters, Karla Zepeda, Scott Overcash, Jordan Coslet, Dalia Tovar, Kia Lee, Mark Koch, Norma Escamilla, Lydia Luna, Erin Mcleod, Kathryn Dykes, Julie A. Ake, Michael Husseman, Janes Fennell, Jennifer Gilsoul, Robert Hoki, Ashley MacDonald, Mia Lobato, Peter Silas, Cody Hawkes, Jennifer Cooper, Jennifer Nelson, Jerica Twitchell, Kenneth Steil, Mildred DeJesus, LaShonda Gilbert, Carey Goldsmith, Maria Gustilo, Jaimi Jones, Mark McKenzie, Teresa Deese, Mitsi Earwood, Vickie Leathers, Diane Sproles, Obadias Marques
Journal: JAMA Network Open (2023)

Greater than 20% of cases and 0.4% of deaths from COVID-19 occur in children. Following demonstration of the safety and efficacy of the adjuvanted, recombinant spike protein vaccine NVX-CoV2373 in adults, the PREVENT-19 trial immediately expanded to adolescents.