tbuckley/cabot-search huggingface dataset:
Paul Epstein, MD, MACP (20 November 1940–12 March 2009): A Good and Honorable Man
Journal: Annals of Internal Medicine (2009)

In Memoriam2 June 2009Paul Epstein, MD, MACP (20 November 1940–12 March 2009): A Good and Honorable ManThe EditorsThe EditorsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-11-200906020-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Our friend Paul Epstein died in March of this year. Two years earlier, in good health and in his full powers, he had suffered a stroke. He was making a gradual recovery when the other shoe dropped. This man we loved bore the burdens of pancreatic cancer for a year before leaving us at age 68.Paul began at Annals of Internal Medicine as an Associate Editor in 1977 and retired in 2007 after spending 10 years as a Deputy Editor. That's 30 years of service to Annals and its readers.Paul was a cheerful man. Like all physicians, he ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 2 June 2009Volume 150, Issue 11Page: 815KeywordsPancreatic cancerPrevention, policy, and public healthPulmonary diseasesSafety studiesStroke ePublished: 2 June 2009 Issue Published: 2 June 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Narcotics Anonymous
Authors: None Anonymous
Journal: JAMA (1985)

<h3>To the Editor.—</h3> As a recovering physician addict, I don't believe that I can concur with Dr Khantzian's<sup>1</sup>statement that "physicians consistently respond favorably [to supervised treatment and advocacy]," for my experience during four years of recovery has been that physicians are the most stubborn of the stubborn, with relapses and deceptions commonplace. What really moved me to write, however, was the kindness and positive step of referring to the organization, Narcotics Anonymous (NA). Very few national publications even mention NA as a source of experience in recovering from drug addiction. I was fortunate to have been introduced to NA during residential treatment for my addiction over four years ago, and it has been my comfortable home ever since. I did not have a positive drug history for alcohol abuse, found NA full of serious, down-to-earth people, and related forcefully to the experiences that NA brought to bear. Further
IL-10–producing and naturally occurring CD4+ Tregs: limiting collateral damage
Authors: Anne O’Garra, Pedro L. Vieira, Paulo Vieira, Anne E. Goldfeld
Journal: Journal of Clinical Investigation (2004)

Effective immune responses against pathogens are sometimes accompanied by strong inflammatory reactions. To minimize damage to self, the activation of the immune system also triggers anti-inflammatory circuits. Both inflammatory and anti-inflammatory reactions are normal components of the same immune response, which coordinately fight infections while preventing immune pathology. IL-10 is an important suppressive cytokine, produced by a large number of immune cells in addition to the antigen-driven IL-10–producing regulatory and the naturally occurring suppressor CD4+ T cells, which is a key player in anti-inflammatory immune responses. However, additional mechanisms have evolved to ensure that pathogen eradication is achieved with minimum damage to the host. Here we discuss those mechanisms that operate to regulate effector immune responses.
UNGUAL UNCERTAINTIES
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SportsMedUpdate
Authors: Martin P Schwellnus
Journal: British Journal of Sports Medicine (2010)

1. Lee SY, 2. McKeon P, 3. Hertel J . Phys Ther Sport 2009;10:12–18. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] ### Background Among many treatment options for plantar fascial injury, foot orthoses are included—the efficacy of orthoses in reducing pain and improving function for this condition has been investigated. ### Research question/s Do foot orthoses improve self-reported pain and function in patients with plantar fasciitis? ### Methodology Experimental procedure: This meta-analysis was conducted after identifying six studies that met the inclusion criteria (only randomised controlled trials or prospective cohort studies, subjects with plantar fasciitis at recruitment, self-reported pain and/or function were assessed, data included reporting of means, SD and sample sizes). Efficacy on pain and function was compared against night splint use, and over three periods (>6 weeks, 6–12 weeks and >12 weeks). Measures of outcome: % improvement in pain and function. ### Main finding/s ### Conclusion/s In a meta analysis of six studies, foot … [1]: {openurl}?query=rft.stitle%253DPhys%2BTher%2BSport%26rft.aulast%253DLee%26rft.auinit1%253DS.%2BY.%26rft.volume%253D10%26rft.issue%253D1%26rft.spage%253D12%26rft.epage%253D18%26rft.atitle%253DDoes%2Bthe%2Buse%2Bof%2Borthoses%2Bimprove%2Bself-reported%2Bpain%2Band%2Bfunction%2Bmeasures%2Bin%2Bpatients%2Bwith%2Bplantar%2Bfasciitis%253F%2BA%2Bmeta-analysis.%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.ptsp.2008.09.002%26rft_id%253Dinfo%253Apmid%252F19218074%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1016/j.ptsp.2008.09.002&link_type=DOI [3]: /lookup/external-ref?access_num=19218074&link_type=MED&atom=%2Fbjsports%2F44%2F6%2F471.atom [4]: /lookup/external-ref?access_num=000264248600004&link_type=ISI
Unintentional Carbon Monoxide Poisonings in Residential Settings—Connecticut, November 1993-March 1994
Journal: JAMA (1995)

Carbon monoxide (CO) gas is an environmental hazard, and unintentional CO poisonings have occurred in multiple settings, including residences, motor vehicles, and workplaces. In 1993, exposure to CO produced by a malfunctioning natural gas furnace in a Suffield, Connecticut, home resulted in the deaths of three children and hospitalization of four other family members. Publicity resulting from this and other CO poisoning incidents prompted concern that gas furnaces have been a primary cause of residential CO poisonings in Connecticut. To determine the sources of residential CO poisonings in Connecticut, the Connecticut Department of Public Health (CDPH) surveyed persons with cases of CO poisoning during November 1993-March 1994. This report presents the survey findings.
Treatment of pericardial effusion with local corticosteroid injections
Authors: Z. J. Twardowski
Journal: JAMA (1984)

<h3>In Reply.—</h3> I am grateful to Dr Twardowski for calling to my attention his report of intrapericardial injections of corticosteroids as a treatment for uremic pericarditis, which no doubt led others later to try to perfect and popularize this method. However, he is not correct when he states that "local steroids were always used in conjunction with drainage." In the references we cited for treatment of tamponade caused by rheumatoid pericarditis, the patients were treated with aspiration and instillation of deposteroids alone, without prolonged drainage. We are also aware of a report of similar management to avoid prolonged drainage or pericardectomy in tamponade from other causes.<sup>1</sup>Those authors concluded, "We feel that hemodynamically significant uremic pericardial effusions should be treated first by pericardiocentesis and intrapericardial instillation of triamcinolone hexacetomide. We would reserve pericardiectomy for those cases in which loculations prevent adequate aspiration of the effusion or in which tamponade
Table of Contents
Authors: James Field, Andrew Miller, John Fain, George Bray, Myriam Fornage, George Papanicolaou, Cora Lewis, Eric Boerwinkle, David Siscovick, Vincent De Meijer, Hau Le, Jonathan Meisel, M Akhavan, Amy Pan, Vânia Nosé, Mark Puder
Journal: Metabolism (2010)
PWE-001 Bile acids modulate Golgi structure in gastrointestinal cancer via a PKC\η\PKD-dependent pathway
Authors: A Byrne, E Foran, R Shamra, J O Sullivan, D O Donoghue, D Kelleher, A Long
Journal: Gut (2010)

<h3>Introduction</h3> Deoxycholic acid (DCA) is a bile acid implicated in pathogenesis of colon cancer as (i) it activates pathways associated with tumorigenesis, particularly the protein kinase C (PKC) pathway (ii) it is pro-tumorigenic in rodent models of colon cancer and (iii) elevated serum and faecal levels are found in patients with colorectal cancer. Ursodeoxycholic acid (UDCA) is currently used clinically to treat biliary disease. Studies have demonstrated a chemopreventative effect in rat models of colon cancer and retrospective analyses of clinical trials have demonstrated chemopreventative effects in development of colon cancer. Bile acids are known to modulate the activation of a number of PKC isoforms (α, β, δ and ε). In this study we investigated the effects of bile acids on subcellular localisation and activity of Protein Kinase Cη (PKCη) and its downstream effects on Golgi structure in gastrointestinal cell lines and colorectal tissue. <h3>Methods</h3> Subcellular localisation and activity of PKCη and PKD was assessed by immunofluorescence and Western Blot analysis, respectively. Golgi were visualised by immunofluorescence and Golgi fragmentation was quantified by high content screening using the Incell-1000 and GE-software analysis. The effect of DCA on secretory mechanisms in the cell was assessed using a Gaussian luciferase reporter assay. Since UDCA has anti-inflammatory properties, the involvement of the glucocorticoid receptor (GR) in UDCA signalling was assessed using pharmacological inhibition and an siRNA approach. Tissue microarrays were utilised to assess Golgi structure in normal, ulcerative colitis (UC) and colon cancer tissue. <h3>Results</h3> Analysis of Golgi architecture showed significant increases in Golgi fragmentation in UC and colorectal cancer tissue (p&lt;0.0005 vs normal) suggesting that Golgi fragmentation may be an important mechanism in disease. We hypothesised that this could be mediated through bile acid exposure. Exposure of HCT116 colon cancer cells to DCA caused phosphorylation of PKCη and PKD and fragmentation of the Golgi. Furthermore DCA exposure decreased secretion of Gaussian luciferase by HCT116 cells (p&lt;0.001 vs control). Pre-treatment of cells with UDCA or dexamethasone, inhibited DCA-induced PKCη/ PKD phosphorylation and Golgi fragmentation. Inhibition of the GR abrogated UDCA effects on DCA-induced Golgi fragmentation. <h3>Conclusion</h3> DCA disrupted the structure and function of the Golgi, an organelle critical for normal cell homeostasis whereas UDCA could attenuate these effects. This study identified novel mechanisms of bile acid signalling which may play a role in the pathogenesis of benign and malignant gastrointestinal disease.
Nutmeg Intoxication
Authors: Robert B. Payne
Journal: New England Journal of Medicine (1963)

WITH the geometric multiplication of drugs available for use in the 1960's and with the corresponding increase in side effects, toxicity and complications, it is refreshing to report anew a toxic state attributable to a common household spice — nutmeg — used since the Middle Ages. Nutmegs were introduced into Europe by the Arabs in the middle of the twelfth century,1 and poisoning with this spice was probably documented as early as 1576.2 Nutmegs are the dried seed kernels of a tall evergreen tree, Myristica fragrans, indigenous to the Molucca Islands of the South Pacific, and now widely cultivated on . . .
CARDIAC ARRHYTHMIAS
Authors: T. East
Journal: BMJ (1953)

The illustrations were all specially prepared and were based on photographs of actual dissections of the cadaver, so that the " final drawing is in every case a faithful representation of the anatomical findings encountered at swrgery."This must have entailed an enormous amount of work, and the authors are to be congratulated on the successful result.But a word of caution must be sounded.Every senior surgeon knows, and the junior surgeon will soon learn, that in many if not in most instances the parts seen at operation are seriously altered by disease or trauma, and the normal appearances depicted in this book will appear distorted and sometimes almost unrecognizable.Moreover, in dealing with malignant turnours one may have to discard all set incisions in order to cut clear of the growth.The pictures here will no doubt help many a novice and may give many a useful suggestion to the experienced surgeon.It would be a good plan if at least some of the main exposures could have been printed in colour, though no doubt that would have added greatly to the expense.
Cardiovascular effects of octreotide in patients with hepatic cirrhosis
Authors: P MCCORMICK
Journal: Hepatology (1995)

Octreotide is thought to reduce splanchnic and variceal blood flow with minimal effects on the systemic circulation in cirrhotic patients with portal hypertension. However, we noticed significant bradycardia in some patients immediately after administration of bolus doses of octreotide. Therefore, we investigated the effect of intravenous octreotide on systemic hemodynamics in 59 patients with cirrhosis. In two double-blind, placebo-controlled protocols, 32 patients received a 25-μg bolus and 20 patients received an infusion of 50-μg/hr of octreotide/placebo. Immediately after the bolus dose of octreotide was administered, there were significant reductions in pulse rate (77 ± 3 vs. 65 ± 3 beats per minute, P < 0.01) and cardiac output (9.2 ± 0.8 vs. 7.9 ± 0.8 L/min; P < 0.01) and significant increases in mean arterial pressure (81 ± 3 vs. 87 ± 3 mm Hg; P < 0.05), mean pulmonary artery pressure (9.1 ± 1.0 vs. 16.6 ± 1.5 mm Hg; P < 0.01), right atrial pressure (3.8 ± 0.8 vs. 6.6 ± 1.0 mm Hg; P < 0.01), right ventricular pressure (7.1 ± 0.6 vs. 12.5 ± 1.3 mm Hg; P < 0.01), pulmonary capillary wedge pressure (4.8 ± 0.8 vs. 11.2 ± 1.4 mm Hg; P < 0.01), systemic vascular resistance, and pulmonary vascular resistance. Thirty minutes after the start of the infusion, there were significant increases in mean right atrial pressure, right ventricular pressure, pulmonary artery pressure, and pulmonary capillary wedge pressure. This study suggests that intravenous octreotide has significant effects on the systemic circulation in patients with cirrhosis and that these effects appear to be more marked after administration of bolus doses.
Individualized care, as well as intensive care, may reduce morbidity among premature infants
Authors: J. W. Zylke
Journal: JAMA (1990)

A NEONATAL intensive care unit is nothing like a womb. But perhaps it should be. Some investigators wonder if the stress of such a noisy, bright environment is contributing to the morbidity of premature infants. Great strides have been made over the last decade in improving survival of low—birth-weight infants. For those infants who weigh 750 to 999 g, survival has increased from 50% to 82%; for those infants who weigh 500 to 750 g, survival has increased from 11% to 36%. And, with the recent licensing of surfactant, it is likely that these figures will continue to improve. <h3>What Price Survival?</h3> This good news is offset in part by concern about the health of the survivors. Studies of older "ex-premies" suggest that they have motor deficits, learning disorders, and behavioral and attention problems. In one study by Mary Bozynski, MD, a neonatologist at the University of Michigan, Ann Arbor,
THE TREATMENT OF MUSCULAR DYSTROPHY WITH GLYCINE
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NIH collaboration with French AIDS vaccine researcher put on hold pending investigation
Authors: C. Marwick
Journal: JAMA (1991)

ASSERTIONS by a<i>Chicago Tribune</i>reporter, John Crewdson, have led the National Institutes of Health (NIH) to call a halt to collaboration with a French investigator, Daniel Zagury, MD, Pierre and Marie Curie University of Paris. Crewdson asserts that regulatory requirements for protection of human research subjects were violated (by not obtaining proper approval for clinical studies of a candidate who participates in acquired immunodeficiency syndrome [AIDS] vaccine research). Since the NIH's Office for Protection From Research Risks' investigation is still under way and not expected to be finished before next month, there is no official comment from the Bethesda, Md, campus (<i>JAMA</i>. 1991;265:2309-2311). Besides his recent reports and others on AIDS research, Crewdson is the author of a lengthy series of articles, published in the<i>Chicago Tribune</i>in November 1989, that dealt with AIDS research and the controversies surrounding it. The Paris-based national French newspaper<i>Le Monde</i>("The World")
Experimental Pharmacology as a Basis for Therapeutics: A Text-Book for Students and Physicians.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impact on health perception, quality of life and labor productivity of antiviral treatment for hepatitis C in patients without significant fibrosis
Authors: Matias Estevez, Jose Miguel Rosales Zabal, Francisco Luis Bellido Muñoz, Marta Casado, Maria Angeles Lopez Garrido, Carmen Molina Villalba, Carolina Molina Maldonado, Cristina Viñolo-Ubiña, Francisco Javier Gallego Rojo
Journal: Journal of Hepatology (2020)
Tropicamide: Comparative Mydriatic Effects
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal