tbuckley/cabot-search huggingface dataset:
Fortschritte der Naturwissenschaftlichen Forschung.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Decrease in Hydroxyproline Excretion in a Patient With Marfan's Syndrome After Methandrostenolone Therapy
Authors: Charles R. Jones
Journal: JAMA (1969)

Long-term methandrostenolone therapy was associated with a markedly lowered hydroxyproline excretion and increased physical well-being in a 36-year-old patient with Marfan's syndrome. It is suggested that the anabolic steroid favorably affected collagen metabolism in this patient.
The Cardiac Pathology of Sudden, Unexplained Nocturnal Death in Southeast Asian Refugees
Authors: Robert H. Kirschner
Journal: JAMA (1986)

Sudden death during sleep has occurred among previously healthy Southeast Asian male refugees, but routine autopsies have not determined the cause of death in any of these cases. We report the first systematic attempt to define the cardiac abnormalities associated with this syndrome. Among 18 hearts examined, 14 showed slight to significant cardiomegaly, characteristic of increased cardiac work load. The reasons for the cardiomegaly remain unexplained. Conduction system anomalies were present in all but one heart. These included persistent fetal dispersion of the atrioventricular node and/or bundle of His, present in 14 hearts; accessory conduction fiber connections, found in 13 cases; and congenital heart block, observed in one case. These abnormalities were associated with variations in the structure of the cardiac base, suggesting a common aberrant developmental process. Although the functional significance of these findings has not been established, the conduction system anomalies may be the substrate for sleep-related cardiac arrhythmias and sudden death. (<i>JAMA</i>1986;256:2700-2705)
One Aspirin Can't Prevent a Stroke but Can Prevent a Major Vascular Event
Authors: Malcolm O. Perry
Journal: JAMA (1987)

<h3>To the Editor.—</h3> On page 2134 of the MEDICAL NEWS &amp; PERSPECTIVES section of the April 24, 1987, issue of<i>JAMA</i>, the title describing the results of the United Kingdom Transient Ischemic Attack/Aspirin Trial<sup>1</sup>is in error. It states that aspirin prevented stroke, but the difference in the incidence of cerebral infarction among the patients receiving a placebo and those receiving aspirin was not statistically significant. A difference in outcome could be found only when other major vascular events (myocardial infarction and sudden death from unknown causes) were also considered. The risk of cerebral infarction was not significantly reduced by the administration of aspirin, a finding similar to the findings in some other studies.<sup>2</sup>Thus, the title is incorrect and misleading. Furthermore, if one fourth of the patients were women, then more than 600 women were enrolled in the study after having experienced a transient ischemic attack or
On Blowing One's Mind (19th-Century Style)
Authors: L. R. C. Agnew
Journal: JAMA (1968)

A few years ago I chanced upon a curious little book with the engaging, albeit long-winded, title of<i>The Chemical Experimentalist; or, an attempt to allure by Experiment, and guide by Reasoning, the enquirer after Rational Amusement and Useful Knowledge, Towards the cultivation of the simple and sublime Science—Chemistry</i>. This work is a remarkable hodge-podge of chemical experiments that one can perform at home, hints on cleaning silver and dying cloth, and even a section on the Philosophy of Nature wherein the author solemnly declares, inter alia, "that comets are male planets, and that their tails are their generative organs." That a comet might possess a phallus and could thus presumably indulge in venery on a celestial scale is an intriguing enough notion, but to my mind the most entertaining item in the<i>Chemical Experimentalist</i>is the apparently serious suggestion that nitrous oxide could replace alcohol as a social stimulant.
Conflict of Interest Dilemmas in Biomedical Research
Authors: Michael D. Witt
Journal: JAMA (1994)

BIOMEDICAL researchers in medical centers, universities, and other nonprofit research institutions routinely collaborate with for-profit companies on research. These academic-industry collaborations have generated lifesaving new products, as well as profits for the companies and the researchers. Because of the beneficial effect of biomedical technology transfers on the United States' competitiveness and public health, Congress has made a national priority of bringing academia and industry together.<sup>1,2</sup>However, the industry-academia collaborations have their costs. They create conflicts between the researcher's (and possibly the institution's) academic interests and financial interests. These conflicts of interest threaten the objectivity of science, the integrity of scientists and institutions, and the safety of medical products. At the present time, federal employees working in federal laboratories are constrained by numerous conflict of interest restrictions.<sup>3,4</sup>Researchers outside the federal government, however, are subject to minimal restrictions, even if they receive federal funds. This article examines the existing
Authors and Editors in the Seventh Decade
Authors: Alfred Soffer
Journal: JAMA (1966)

The increase in the number of publications from departmental and interdepartmental teams of investigators within academic centers represents a striking trend in medical literature in this century. Is this phenomenon an editorial vagary or is it related to fundamental changes in medical practice and clinical investigation? Transformations in medical communication can be understood only in the context of dramatic sociological changes which have occurred in this country in the past 60 years. Subdivision of practitioners into numerous specialties became feasible as an agrarian society became an urban-centered civilization and large numbers of physicians gravitated to metropolitan areas. The recent explosion of medical knowledge gave further impetus to specialization, for it became more difficult for the individual to master the burgeoning technical contributions. More and more, practice became a team effort, and the increasing number of clinics testifies to the desire for clinicians to band together to provide comprehensive service. Charles
Text-Book of Physiological and Pathological Chemistry.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
International Public Health
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Animal Parasites and Human Disease.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physician Response to Fee Changes
Authors: Paul B. Ginsburg
Journal: JAMA (1993)

THE PHYSICIAN Payment Review Commission, Washington, DC, has a long-standing interest in measuring physicians' response to changes in payment rates (called "behavioral offset"). A summary of our recent empirical work on this subject is included in the commission's 1993 report to Congress.<sup>1</sup> In this issue, Escarce<sup>2</sup>analyzes Medicare claims before and after the overvalued procedure fee reductions specified in the Omnibus Budget Reconciliation Act of 1987 (OBRA 87). He purports to show that the OBRA 87 cuts generated no net behavioral offset. See also p 2513. We disagree with Escarce's conclusion: we believe the Medicare data provide good evidence of a behavioral offset. We frame herein the policy issue, identify the important methodological differences between Escarce's analysis and our own, and summarize findings from our own studies of the OBRA 87 fee reductions and subsequent policy-driven changes in Medicare fees. The issue of the behavioral offset gained broad
Technetium-99m White Blood Cell Imaging
Authors: BARRY H. GUZE, RANDALL A. HAWKINS, CAROL S. MARCUS
Journal: Clinical Nuclear Medicine (1989)

The authors report a case of sickle cell anemia associated osteomyelitis where the Tc-99m white blood cell imaging was negative, and bone imaging showed increased uptake in the region in question. The reasons for the possible false-negative image are discussed.
Buchanan's "Manual of Anatomy."
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rest/Stress Intradermal Lymphoscintigraphy for the Functional Imaging of the Lymphatic System
Authors: Girolamo Tartaglione, Francesco Pio Ieria, Giuseppe Visconti, Roberto Bartoletti, Giulio Tarantino, Daniele Aloisi, Stefano Gentileschi, Marzia Salgarello
Journal: Clinical Nuclear Medicine (2022)

Purpose Lymphoscintigraphy is the criterion-standard method for diagnosing lymphedema, and there is no universally standardized imaging modality. In our center, we use a new approach: rest/stress intradermal lymphoscintigraphy. Methods We tested 231 consecutive patients with suspected lymphedema. All patients were studied after a complex physical therapy program to reduce edema. Two doses of 99m Tc-nanocolloid were injected intradermally. Two static planar scans were taken at rest following tracer injection. Next, patients performed an isotonic muscular exercise for 2 minutes followed by postexercise scans. Subsequently, a prolonged exercise was performed for 30 to 40 minutes, after which delayed scans were taken. Abnormal patterns were distinguished into minor or major findings, according to severity. Results We identified superficial lymphatic vessels and regional lymph nodes in approximately 80% of limbs. Deep vessels were visualized in 26% of limbs. Minor findings were reported in 22.7% of limbs examined, whereas major findings were reported in 53.2% of limbs. Conclusion We observed major findings including lymph stagnation, extravasation, or dermal backflow in a significantly higher percentage of limbs with secondary lymphedema than in primary. We also observed the deep lymphatic pathways in a significantly higher percentage of limbs with primary lymphedema. Intradermal radiotracer injection, combined with isotonic muscular exercise, may offer a better and faster imaging of lymphatic pathways, evaluating the effects of muscular exercise on lymphatic drainage. Based on the in-depth information of the lymphatic pathways provided by rest/stress intradermal lymphoscintigraphy, microsurgeons can obtain important functional information to perform supermicrosurgical lymphatic-venous anastomosis or vascularized lymph node transfer.
Selected Articles from This Issue
Journal: Clinical Cancer Research (2022)

Highlights| October 03 2022 Selected Articles from This Issue Author & Article Information Online ISSN: 1557-3265 Print ISSN: 1078-0432 ©2022 American Association for Cancer Research2022American Association for Cancer Research Clin Cancer Res (2022) 28 (19): 4159. https://doi.org/10.1158/1078-0432.CCR-28-19-HI Related Content A commentary has been published: Clinical, Pathologic, and Molecular Prognostic Factors in Patients with Early-Stage EGFR-Mutant NSCLC A commentary has been published: Detection of Occult Recurrence Using Circulating Tumor Tissue Modified Viral HPV DNA among Patients Treated for HPV-Driven Oropharyngeal Carcinoma A commentary has been published: Microsatellite Instability–High Endometrial Cancers with MLH1 Promoter Hypermethylation Have Distinct Molecular and Clinical Profiles View more A commentary has been published: OLIG2 Is a Determinant for the Relapse of MYC-Amplified Medulloblastoma View less Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record October 3 2022 Citation Selected Articles from This Issue. Clin Cancer Res 1 October 2022; 28 (19): 4159. https://doi.org/10.1158/1078-0432.CCR-28-19-HI Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Patients with MYC-amplified medulloblastoma (MB) have poor prognosis and frequently develop recurrence; thus new therapeutic approaches to prevent recurrence are needed. Here, Xu and colleagues demonstrate that OLIG2-expressing tumor cells are highly enriched in therapy resistant and recurrent MYC-amplified MB and high levels of OLIG2 correlated with poor prognosis. Genetic or pharmacological inhibition of OLIG2 in combination with radiotherapy significantly suppressed the progression of OLIG2-high tumors in patient-derived xenograft mouse models, indicating that OLIG2 represents a novel therapeutic target in high-risk MB. CT-179 is a highly potent and selective small molecule OLIG2 inhibitor. The study provides evidence for CT-179 to potentially act as an adjunctive therapy for patients with high-risk MB as well as other types of pediatric brain tumors where OLIG2 is highly expressed. Thus patients with these cancers may also benefit from CT-179 treatment. Cell-free tumor tissue modified viral (TTMV)-HPV DNA is a unique biomarker, present... You do not currently have access to this content.
Diabetes management in chronic kidney disease: a consensus report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO)
Authors: Ian H. de Boer, Kamlesh Khunti, Tami Sadusky, Katherine R. Tuttle, Joshua J. Neumiller, Connie M. Rhee, Sylvia E. Rosas, Peter Rossing, George Bakris
Journal: Kidney International (2022)
Role of the faecal immunochemical test in patients with risk-stratified suspected colorectal cancer symptoms: A systematic review and meta-analysis to inform the ACPGBI/BSG guidelines
Authors: Richard Booth, Rachel Carten, Nigel D'Souza, Marie Westwood, Jos Kleijnen, Muti Abulafi
Journal: The Lancet Regional Health - Europe (2022)

The UK National Institute for Health and Care Excellence (NICE), recommended in 2017 the use of the faecal immunochemical test (FIT) to guide investigations in patients presenting with NICE-defined low-risk symptoms suspicious for colorectal cancer (CRC). At that time, NICE did not recommend FIT use for high-risk symptoms. This is the first systematic review to evaluate the diagnostic accuracy of FIT in NICE-defined high and low-risk symptoms and was designed to inform the joint ACPGBI/BSG guidelines.
Neoplastic Diseases in Simians&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1968)

Journal Article Neoplastic Diseases in Simians Get access Marion Valerio, Marion Valerio Bionetics Research Laboratories, Inc., Falls Church, Virginia 22046 Search for other works by this author on: Oxford Academic PubMed Google Scholar J. C. Landon, J. C. Landon Bionetics Research Laboratories, Inc., Falls Church, Virginia 22046 Search for other works by this author on: Oxford Academic PubMed Google Scholar J. R. M. Innes J. R. M. Innes Bionetics Research Laboratories, Inc., Falls Church, Virginia 22046 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 40, Issue 4, April 1968, Pages 751–756, https://doi.org/10.1093/jnci/40.4.751 Published: 01 April 1968 Article history Received: 29 August 1967 Accepted: 07 November 1967 Published: 01 April 1968
Therapeutic Effect of Combination Antiretroviral Therapy on Cytomegalovirus Retinitis
Authors: Scott M. Whitcup
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Cytomegalovirus (CMV) retinitis is the most common intraocular infection in patients with acquired immunodeficiency syndrome (AIDS) and tends to occur after CD4<sup>+</sup>cell counts decrease to less than 0.10X 10<sup>9</sup>/L.<sup>1</sup>Although anti-CMV therapy with ganciclovir, foscarnet sodium, or cidofovir initially leads to inactivation of the retinitis in the majority of patients, the disease later progresses in most patients despite continued therapy due to inadequate control of the replicating virus. Without therapy, the median time to detection of progression of CMV retinitis is approximately 2 to 3 weeks<sup>2,3</sup>; resolution of active retinitis without anti-CMV therapy rarely if ever occurs in immunosuppressed patients. Two recent studies have shown that treatment with highly active combination antiretroviral therapy, consisting of nucleoside analogs and protease inhibitors, has led to decreased human immunodeficiency virus (HIV) loads and increased CD4<sup>+</sup>cell counts.<sup>4,5</sup>We present 4 patients with AIDS and
Hazards of Drug Dependency Among Physicians
Authors: Ralph B. Little
Journal: JAMA (1971)

The need to distort reality by resorting to drug dependency may occur in the physician just as it does among others who are unable to resolve their problems constructively. In addition, physicians have an increased hazard because of the availability of drugs and the tendency to self-medication. Other considerations include lack of knowledge of the predrug dependency state, a false sense of immunity, and a failure to recognize that any drug may lead to drug dependency when regularly used.
Finding Our Way on a Path to the Future
Authors: Charles L. Hudson
Journal: JAMA (1966)

It is with the deepest gratitude that I accept the high honor which you have entrusted to me. I am proud to be privileged to put on the mantle of leadership, worn in the past by so many distinguished physicians. I look forward to meeting the responsibilities and challenges that devolve upon all of us at this, for us, dramatic time in the history of medicine. I shall carry the title of President of this Association with understandable pleasure for the next year, and to the best of my ability shall discharge the obligations and responsibilities inherent in this honored position. Yet, I am not so naïve—or so presumptuous— as to believe that the future of medicine in America lies exclusively in my hands, nor that it lies entirely in those of other officers, or of members of boards and councils and of delegates to the legally constituted legislatures of
Awards, Appointments, Announcements
Journal: JNCI Journal of the National Cancer Institute (1989)

Awards, Appointments, Announcements Get access JNCI: Journal of the National Cancer Institute, Volume 81, Issue 19, 4 October 1989, Pages 1448–1449, https://doi.org/10.1093/jnci/81.19.1448 Published: 04 October 1989