tbuckley/cabot-search huggingface dataset:
Short course vs conventional antibiotic therapy after successful biliary drainage in patients with moderate to severe acute cholangitis: Non-inferiority randomized trial
Authors: S. Deshidi, J. Shah, V. Gautam, V. Jearth, A. K. Singh, H. S. Mandavdhare, V. Sharma, S. Irrinki, Y. Sakaray, R. Gupta, S. Rana, U. Dutta
Journal: Endoscopy (2023)

Aims Duration of antibiotic after successful biliary drainage in patients with acute cholangitis has not been prospectively evaluated. We conducted randomized, non-inferiority trial to compare short and conventional duration of antibiotic in patients with moderate to severe cholangitis.
EUS-directed transgastric EUS-guided radiofrequency ablation of a neuroendocrine tumor in the head of the pancreas in a patient with Roux-en-Y gastric bypass anatomy
Authors: K.D. C. Pham, R. Havre
Journal: Endoscopy (2023)

Abstract Text A 70-old lady was operated on with Roux-en-Y gastric bypass for weight loss and developed gradually severe hypoglycemia. On the CT scan, a 14 mm lesion was found at the head of the pancreas, and the biochemical workup indicated an insulinoma. To reach the lesion, a temporary EUS-guided gastro-gastrostomy was created with a LAMS to connect the gastric remnant to the diverted stomach. EUS-FNB was performed, confirming a neuroendocrine tumor. Thereafter, we performed a EUS-guided RFA of the tumor. Immediately, the serum blood sugar increased. After two days of observation, the LAMS was removed. At three months, the blood sugar level was normal. The tumor has also shrunken.
Endoscopic necrosectomy of extensive WON with solid debris using OTSG: Once you dig it, you've got to clean it
Authors: F. Pereira Correia, M. L. Figueiredo, M. A. Rafael, S. Bragança, G. Alexandrino, J. C. Branco, L. Carvalho Lourenço, D. Horta
Journal: Endoscopy (2023)

Walled-Off Necrosis (WON) are peripancreatic collections with variable amount of liquid and solid content. After transgastric drainage, collections with a large amount of solid content often require necrosectomies to optimize the cleaning of the necrotic cavity. Until recently, there were no specific devices for these procedures. We present a case demonstrating the use of over-the-scope grasper (OTSG) in the necrosectomy of a WON with a great content of solid debris. The OTSG demonstrated the ability to optimize endoscopic necrosectomy, making this procedure more effective and faster.
Risk factors for submucosal fibrosis during per-oral endoscopic myotomy: a prospective study
Authors: Z. Nabi, J. Basha, I. Pradev, S. Darishetty, D. N. Reddy
Journal: Endoscopy (2023)

Aims Submucosal fibrosis (SMF) is the most important reason for technical failure during POEM. Prediction of SMF may be crucial to improve technical outcomes with POEM. In this study we aim to evaluate the predictors for SMF in cases with achalasia cardia.
Performance of prognostic risk scores in urgent upper gastrointestinal hemorrhage
Authors: I. Iborra, M. Fortuny, E. Vayreda, A. Calm, L. Gutierrez-Rios, L. Gonzalez-Gonzalez, E. Castillo, N. Caballero, J. Colan-Hernandez, H. Uchima, V. Moreno De Vega, E. Domènech
Journal: Endoscopy (2023)

Aims To evaluate the performance of Glasgow-Blatchford score (GBS), pre-endoscopic (pRS) and complete Rockall score (RS) and Canuka score (CS) to predict readmission, mortality and safe discharge (SD).
Endoscopic treatment of anastomotic stenosis in a patient with pancreas divisum and marsupialization for gastro-duodenal duplication
Authors: M. Gesualdo, S. Dibitetto, M. Sacco, A. Mauriello, F. Castellano, F. Fimiano, M. T. Staiano, E. Dall'Amico, M. Bruno, C. G. De Angelis
Journal: Endoscopy (2023)

Abstract Text A 28 years-old-woman underwent surgical marsupialization at 3 months for gastro-duodenal duplication. She was asymptomatic until a few months ago, when she had two episodes of acute pancreatitis. In MRI pancreas divisum was discovered. In endoscopic view a stenotic anastomosis was found. The surgical solution was duodeno-cephalo-pancreatectomy. Consequently, a first 10x10 mm LAMS and a second one 20x10 mm were applied to dilate the anastomosis. One month later, the cystic cavity was reduced and the duct of Santorini was visible in extraductal ultrasound view. LAMS was removed due to the patient’s clinical well-being. Ten months later, the anastomosis was wide. The patient is now asymptomatic.
Precancerous and cancerous conditions and H. pylori infection in patients undergoing gastroscopy for 1st degree relative for gastric cancer: a cross-sectional study
Authors: I. Ligato, L. Dottori, E. Dilaghi, C. Sbarigia, E. Pilozzi, B. Annibale, E. Lahner, G. Esposito
Journal: Endoscopy (2023)

Aims Gastric cancer (GC) is the fourth cause of death for neoplasia. To reduce GC mortality, a strategy is to diagnose preneoplastic conditions (PNC) in patients with risk factors. Since in first degree relatives (FDR) was found an up to 2.5 times increased risk for GC, recent guidelines suggest only an esophagogastroduodenoscopy (EGDS) screening in patients who have a FDR for GC. If PNC are diagnosed, Euopean guidelines MAPS II, suggest repeating EGDS shortening the interval.The aim is to determine the prevalence of PNC and GC inpatients undergoing EGDS for FDR for GC.
Proactive role of direct peroral cholecystoscopy following endoscopic ultrasound-guided gallbladder drainage with lumen-apposing metal stents – Do we really need permanently indwelling stents?
Authors: R. Kunda, N. Messaoudi, S. M. Chan, A. Y. Teoh
Journal: Endoscopy (2023)

Aims EUS-GBD with LAMS is by convention reserved for non-surgical candidates with acute cholecystitis. Stents are permanently indwelling, despite they are not designed that way. It may lead to various short- and long-term adverse events. A proactive approach with direct peroral cholecystoscopy (DPOCS) and complete stone clearance may allow removal of LAMS and avoid the need for permanent EUS-GBD.
EUS-Directed trans-Gastric Endoscopic Retrograde Cholangiopancreatography (EDGE) in twice surgically-altered anatomy: Roux-en-Y Gastric Bypass after Sleeve Gastrectomy
Authors: G. Vanella, G. Dell'Anna, P. Arcidiacono
Journal: Endoscopy (2023)

Abstract Text A 30-year-old female, with former Sleeve Gastrectomy converted to Roux-en-Y Gastric Bypass, was admitted for symptomatic choledocholithiasis, and candidate to EUS-directed Trans-Gastric ERCP. With this anatomy, the antrum remnant gets smaller and dislocated towards the liver. From deep post-anastomotic jejunum, the pancreatico-duodenal region was identified and followed backwards towards a small antrum remnant, which was distended by needle injection and connected through a 20mm LAMS. After 2 weeks, a through-the-LAMS ERCP was performed. After 2 months a through the-LAMS diagnostic EUS confirmed stones clearance and the stent was removed.
Feasibility and safety of a newly developed Two-in-one covered and uncovered metal stent for inoperable malignant distal biliary obstruction
Authors: M. J. Yang, J. H. Kim
Journal: Endoscopy (2023)

Aims Endoscopic placement of a self-expandable metal stent is the principal method for palliation of inoperable malignant distal biliary obstruction. In the current study, we aimed to evaluate the efficacy and safety of a newly developed double stent which is made of a combination of inner silicone-covered stent and outer bare metal stent (Two-in-one stent) in patients with inoperable malignant distal biliary obstruction.
Contrast enhanced endoscopic ultrasound FNA versus standard FNA in diagnosis of biliary duct tumors
Authors: R. I. Orzan, C. Pojoga, C. Hagiu, O. Mosteanu, I. Rusu, V. Rednic, N. Al Hajjar, R. Agoston, A. Seicean
Journal: Endoscopy (2023)

Aims Contrast enhanced endoscopic ultrasound (CH-EUS) is superior to standard endoscopic ultrasound (EUS) for T staging of biliary duct tumors (BDT) but its role in guiding EUS-fine needle aspiration (EUS-FNA) is unknown. We compared the diagnostic performance of CH-EUS-fine needle aspiration (CH-EUS-FNA) and standard EUS-FNA in BTD and aimed to determine the factors influencing the results.
Analysis of Health-related Quality of Life (HLQOL) among Patients with Stomach Cancer Based on EuroQOL-5 Dimension: A Korean national population-based cross-sectional survey (KHNANES 2007-2020)
Authors: H. J. Jeon, S. C. Hyuk, S. K. Eun, K. Bora, T. J. Yoon, J. C. Hoon
Journal: Endoscopy (2023)

Aims This study investigated the comparison with HLQoL of gastric cancer patients and the factors affecting HLQoL and provided relevant information for adequate support.
Metabolic syndrome is independent risk for colonic adenoma – Detection of colonic polyps in India (DoCPI)
Authors: N. Jagtap, A. Singh, P. Inavolu, Z. Nabi, R. Kalapala, M. Ramchandani, S. Lakhtakia, S. F. Memon, M. Tandan, A. Sekaran, P. Sharma, G. V. Rao, D. N. Reddy
Journal: Endoscopy (2023)

Aims There is limited data on prevalence and risk factors of colonic adenoma from Indian Subcontinent. In the current study, we aimed to evaluate the prevalence and risk factors of colonic adenoma in large prospective cohort.
Artificial intelligence-assisted small bowel capsule endoscopy reading in patients with suspected small bowel bleeding
Authors: S. Piccirelli, C. Hassan, E. Toth, B. Gonzalez, M. Keuchel, M. McAlindon, A. Finta, A. Rosztoczy, X. Dray, D. Salvi, M. E. Riccioni, R. Benamouzig, A. Chattree, J. C. Saurin, A. Humphries, E. Despott, A. Murino, G. Wurm Johansson, A. Giordano, P. Baltes, R. Sidhu, M. Szalai, K. Helle, A. Nemeth, T. Nowak, R. Lin, G. Costamagna, C. Spada
Journal: Endoscopy (2023)

Aims Capsule endoscopy (CE) reading is time consuming, and readers are required to maintain attention to not miss significant findings. Deep neural networks (DNNs) can recognize relevant findings, possibly exceeding human performances, reducing the reading time of CE. Primary aim of this study was to assess the non-inferiority of Artificial intelligence (AI)-assisted vs standard reading for the detection of potentiallly bleeding lesions at per-patient analysis. Secondary aim was to compare the mean reading time in the two modalities.
Performance and outcome of laparoscopic cholecystectomy after endoscopic ultrasound-guided gallbladder drainage with lumen-apposing metal stents – expanding indications of interventional endoscopic ultrasound
Authors: R. Kunda, N. Messaoudi, S. M. Chan, A. Y. Teoh
Journal: Endoscopy (2023)

Aims EUS-GBD with LAMS is by convention limited to patients with acute cholecystitis who are not candidates for surgery. The concept is explored as bridging towards cholecystectomy following resolution of inflammation.
Endoscopic Zenker's diverticulotomy: fewer recurrences due to Z-POEM?
Authors: L. Welsch, M. Mewes, A. Genthner, S. Kangalli, E. Leventi, F. Straulino, A. Eickhoff
Journal: Endoscopy (2023)

Aims Endoscopic diverticulotomy is nowadays the standard procedure for the treatment of symptomatic Zenker's diverticulum. With Z-POEM (peroral endoscopic myotomy), a new technique is now available that may reduce recurrences. Z-POEM has been used at our center since 2021. We retrospectively evaluated data regarding effectiveness and complication rate compared to conventional diverticulotomy. [1]
Endoscopic ultrasound guided hepaticogastrostomy versus percutaneous transhepatic biliary drainage for malignant hilar obstruction: an international multicenter comparative study
Authors: J. Samanta, Z. Nabi, P. Gkolfakis, S. F. Crinò, P. Gupta, J. Dhar, D. Carpentier, M. Benedetto, D. Chiari, F. Antonio, J. Candi, A. Ruzzenente, S. Chandan, B. P. Mohan, V. Gupta, S. Lakhtakia, J. Deviere, D. N. Reddy
Journal: Endoscopy (2023)

Aims Dedicated comparison between the conventional percutaneous transhepatic biliary drainage (PTBD) and the recent endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) for the complex disease anatomy of malignant hilar obstruction (MHO) is lacking and hence this study was planned.
Impact of the COVID – 19 Pandemic on Endoscopic Ultrasound and Radiology Liver Cytopathology Caseload and Diagnostic Accuracy
Authors: K. Dunleavy, R. Graham, M. Olave, M. Levy, E. Rajan, F. Gleeson
Journal: Endoscopy (2023)

Aims In January 2020, the CDC confirmed the first US case of COVID-19 impacting availability of cytopathology services and rapid on-site evaluation (ROSE). Centers reported 76% reduction in lab volume and 150% increase of "suspicious" specimens. At a single US academic center, we sought to determine the impact of the pandemic on our endoscopic ultrasound (EUS) and radiology liver cytopathology specimen volume and diagnostic accuracy.
Prospective validation of a cleanliness scoring system for the upper digestive tract – the visual study
Authors: M. Romańczyk, B. Ostrowski, M. Lesińska, P. Wieszczy-Szczepanik, K. M. Pawlak, K. Kurek, E. Wrońska, K. Kozłowska-Petriczko, M. Waluga, T. Romańczyk, P. Wosiewicz, M. Bugajski, M. Hartleb, M. F. Kamiński, P. Sharma
Journal: Endoscopy (2023)

Aims No widely accepted cleanliness score has been validated for esophagogastroduodenoscopy (EGD) so far. The aim of our study was to assess the relationship between the presence of UGI lesions and a recently created polprep upper-gastrointestinal cleanliness scale (PUCS)1.
A second FIT after a first weak positive one as a useful strategy to reduce colonoscopy load in CRC screening
Authors: C. Borao Laguna, N. Saura Blasco, G. Hijos Mallada, R. Velamazan Sandalinas, A. Lanas Arbeloa, C. Sostres Homedes
Journal: Endoscopy (2023)

Aims The aim is to explore whether in those patients with a first FIT with a low positive determination (≤ 35 µg/Hb/g), a negative second FIT (≤ 20 µg/Hb/g) is associated with a low probability of CRC or those lessions that require endoscopic follow-up, according to ESGE 2020.
Impact of the COVID-19 pandemic on colorectal surveillance in Lynch syndrome – a nationwide study
Authors: E. van Liere, N. De Boer, E. Parsan, M. Van Leerdam, D. Ramsoekh
Journal: Endoscopy (2023)

Aims The COVID-19 pandemic triggered substantial disruptions to health-care, including endoscopy practice. We aimed to quantify the impact of two years COVID-19 on nationwide endoscopic surveillance in Lynch syndrome.
Endoscopic LAMS placement for benign distal colonic obstruction due to complete rectal stricture in a patient with chronic ischemic colitis
Authors: A. Lisotti, D. Trama, S. Guglielmo, R. Linguerri, I. Bacchilega, M. Masetti, P. Fusaroli
Journal: Endoscopy (2023)

Abstract Text To describe LAMS placement in a poor surgical candidate with ischemic colitis and rectal stricture. An 87-year-old patient, refusing any kind of surgery, presented with tenderness and vomit. A tight (2-3 mm) short circumferential stricture was found, with severe dilation of proximal limbs. We deployed a 20x10 mm LAMS (Hot-Axios) under endoscopic and fluoroscopic control and dilated the stent up to 18 mm with a CRE balloon. Finally, a therapeutic gastroscope could easily pass through the LAMS. Obstruction resolved and the patient was discharged 2 days later. Endoscopic LAMS deployment is a valid and effective alternative to endoscopic dilation or SEMS placement, reducing the risk of stent migration.
Diagnostic yield of gastric biopsies of the incisura angularis in patients with gastric intestinal metaplasia in a low incidence gastric cancer region
Authors: F. E. Marijnissen, J.K. F. Pluimers, L. G. Capelle, I. L. Holster, P.J. F. De Jonge, E. J. Kuipers, M. Doukas, M.C. W. Spaander
Journal: Endoscopy (2023)

Aims Patients with gastric intestinal metaplasia (GIM) can be stratified into non-extended and extended GIM. In patients with extended GIM surveillance is recommended based on a higher risk of neoplastic progression. The updated Sydney protocol is the most widely accepted biopsy system to identify extended GIM, and includes, besides biopsies of the corpus and antrum also biopsies of the incisura angularis (IA). However, data on the added value of additional biopsies of the IA in patients with premalignant gastric lesions is scarce. Our aim is to evaluate the yield and added value of the updated Sydney protocol in a low incidence gastric cancer region.
Lumen apposing metal stents for the treatment of pancreatic and peri-pancreatic fluid collection and bleeding risk: a propensity matched study
Authors: D. Paduano, B. Mangiavillano, A. Facciorusso, F. Auriemma, V. M. Jorge, K.D. C. Pham, J. H. Moon, S. F. Crinò, F. Calabrese, G. Aragona, A. Ventra, C. Barbera, S. Lakhtakia, P. Arcidiacono, G. Vannella, G. Valerii, T. Song, A. Y. Teoh, A. Repici, A. Larghi
Journal: Endoscopy (2023)

Aims Endoscopic ultrasound (EUS)-guided drainage with luminal apposing metal stent (LAMS) has become the treatment of choice of symptomatic pancreatic fluid collections (PFCs). Recent studies reported a not negligible bleeding risk after Axios stent placement. Spaxus stent has blunt extremity and a softer design. Our aim was to compare the risk of bleeding between the two stents. (▶[Table 1] [2] [3] [4] [5] [6] [7] [8] [8]).
Propofol-based sedation managed by gastroenterologist versus deep sedation during endoscopic procedures in low anesthesiological risk patients (ASA I-II): a propensity score-matched comparison in a single tertiary center
Authors: F. V. Mandarino, P. Biamonte, N. Salmeri, A. Barchi, L. Massimino, F. Azzolini, L. Fanti, E. Viale, D. Esposito, M. Agostoni, S. Danese
Journal: Endoscopy (2023)

Aims Our aim was to analyze safety outcomes between non-anesthesiologist-administered-propofol (NAAPS) sedation and anesthesiologist-assisted deep sedation (DS) during endoscopic procedures for low-risk patients
Endoscopic magnetic compression anastomosis to treat a complete iatrogenic stenosis of the hypopharynx
Authors: P. Mascagni, I. Boskoski, V. Bove, T. Schepis, V. Perri, G. Costamagna, A. Tringali
Journal: Endoscopy (2023)

Abstract Text A 72-years-old male presented with a complete hypopharyngeal stenosis following laryngeal cancer surgery and radiotherapy. Balloon dilatations and endoscopic ultrasound-guided recanalization failed, so a magnetic compression anastomosis was attempted. A magnetic ring was placed at the distal side of the stenosis through the gastrostomy site while another magnetic ring was inserted through the mouth. The procedure was successfully completed, the patient was discharged after 24 hours, magnets were expelled after 11 days, and, following regular balloon dilations, was able to eat after 3 months. This is the first report of endoscopic magnetic compression anastomosis to treat a complete hypopharyngeal stenosis in adults.
English National Root-Cause Analysis of Post-Colonoscopy Colorectal Cancers
Authors: N. Burr, D. Beaton, N. Trudgill, E. Morris, R. Valori
Journal: Endoscopy (2023)

Aims To create a process for identifying post-colonoscopy colorectal cancers (PCCRCs), introduce a review template to identify the most plausible explanation for the PCCRC, and use the evidence captured to inform recommendations to reduce rates
Is there a relationship between ERCP outcomes and ERCP volume per center and endoscopist? A systematic review and meta-analysis
Authors: S. Campos, A. Papaefthymiou, T. Florou, F. Antonio, M. Arvanitakis, J. Deviere, P. Gkolfakis
Journal: Endoscopy (2023)

Aims Center/endoscopists' volume might have a relation with ERCP outcomes, as in other fields of endoscopy and in surgery. An effort to assess this relationship is important to improve practices. This study aimed to evaluate the association between ERCP outcomes and volume per endoscopist and center, through a systematic review and meta-analysis.
Assessment of independent predictors for high-grade dysplasia or adenocarcinoma and the long-term mortality in patients with mucinous pancreatic cystic lesions
Authors: S. Wesali, A. Molinaro, B. Lindkvist, P. Hedenström, R. Sadik
Journal: Endoscopy (2023)

Aims The aims of this prospective study were to identify independent risk factors for the presence of high-grade dysplasia (HGD) or adenocarcinoma in mucinous pancreatic cystic lesions (PCLs) and to assess the mortality of this heterogenous group of patients.
The same factors impact differently on time to death in patients with acute non variceal upper gastrointestinal bleeding: a prospective cohort study
Authors: C. Bucci, C. Marmo, M. Soncini, M. E. Riccioni, R. Marmo
Journal: Endoscopy (2023)

Aims 30-day mortality is the accepted definition to relate the death risk to the bleeding event in cirrhotic patients[CB1]. Still, death can be due to bleeding or non-bleed-related factors, such as worsening comorbidities. Identifying such factors is helpful for the patient's management. We aimed to verify if the elements involved in the death risk were the same from admission to 30 days.
Residual malignant cells are present on endoscopic instruments and/or working channel in almost half of the cases after endoscopic biopsies for cancer or ESD
Authors: P. Leclercq, O. Plomteux, S. Vansteenberge, J. Radermacher, N. Bletard, J. Jacques, R. E. Pouw, R. Bisschops
Journal: Endoscopy (2023)

Aims ESGE suggests obtaining possible non-neoplastic biopsies before suspected malignant lesions to prevent the intraluminal spread of malignant disease. We looked for residual malignant cells in the endoscope working channel (EWC), and on the biopsy forceps or knife, after biopsies (Bx) of colorectal cancer (CRC) or endoscopic submucosal dissection (ESD) for early neoplasia.
Infective endocarditis as possible complication of endoscopic stricture dilation in Crohn's disease
Authors: A. Gonçalves, M. Silva, S. Barbeiro, H. Vasconcelos
Journal: Endoscopy (2023)

Methods The authors present a case present a case of an infective endocarditis following a dilation of a Crohn-related intestinal stricture [1] [2] [3].
Comparison of Diagnostic Performances in Endoscopic Ultrasound-guided Liver Biopsy using Different Techniques
Authors: C. M. Cho, D. W. Lee, G. C. Kim, A. N. Seo, H. I. Bae
Journal: Endoscopy (2023)

Aims Endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) for hepatic solid lesions has emerged as a safe technique to diagnosis. However, the optimal FNB techniques have not been evaluated. Our study aimed to compare the diagnostic yield and specimen adequacy of EUS-FNB in hepatic solid lesions using different FNB techniques ([Table 1]).
Motorized Spiral Enteroscopy: preliminary results of a multicenter prospective experience in real life clinical setting
Authors: A. Mussetto, C. Casadei, M. Trebbi, D. Salvi, F. Fornaroli, A. Michielan, G. De Pretis, G. L. De' Angelis, C. Spada
Journal: Endoscopy (2023)

Aims The motorized spiral enteroscopy (MSE) is the latest advancement in enteroscopy;however, real-life data on efficacy and safety are scarce.
Early versus delayed resumption of anticoagulation after endoscopic hemostasis in upper gastrointestinal bleeding: a propensity-score analysis
Authors: L. H. Lau, M. Dai, C. L. Guo, X. Xiao, B. Y. Ip, S. C. Ng, G. L. Wong, F. K. Chan
Journal: Endoscopy (2023)

Aims There were limited data on optimal timing of anticoagulant resumption after upper gastrointestinal bleeding (UGIB) and endoscopic hemostasis. We aimed to evaluate the rebleeding and thrombotic risks in early or delayed anticoagulant resumption.
Combination of ERCP and EUS-guided intrahepatic biliary drainage with gallbladder (modified-CERES) in malignant hilar obstruction
Authors: M. Puigcerver-Mas, C. F. Consiglieri, A. Garcia-Sumalla, D. Luna-Rodriguez, S. Maisterra, S. Quintana-Carbó, J. B. Gornals
Journal: Endoscopy (2023)

Abstract Text Introduction: A 85-year-old male with jaundice and cholangitis due to unresectable hilar cholangiocarcinoma (Klatskin,IV). A CERES with retrograde biliary drainage (ERCP) combined with a transmural endosonography (EUS) intrahepatic and gallbladder drainage is proposed [1].
Device assisted endoscopic full thickness resection in colorectum: a systematic review and meta-analysis
Authors: J. Dhar, Z. Nabi, J. Samanta, D. N. Reddy
Journal: Endoscopy (2023)

Aims Endoscopic full thickness resection (EFTR) is emerging as an effective modality for mucosal and submucosal lesions in colorectum. In this systematic review and meta-analysis, we aimed to analyze the success and safety of device-assisted EFTR in colorectum.