POS1082 CHARACTERISTICS OF PSORIATIC ARTHRITIS (PSA) PATIENTS WITH ENTHESITIS. DATA FROM RUSSIAN PSA REGISTRY (RU-PSART).
Authors: E. Loginova, T. Korotaeva, E. Gubar, Y. Korsakova, S. Glukhova, E. Nasonov, V. Sorotskaya, I. Patrikeeva, P. Shesternya, I. Shchendrigin
Journal: Annals of the Rheumatic Diseases (2022)

Background Psoriatic arthritis (PsA) is a disease with multidomain clinical presentation such as arthritis, enthesitis, dactylitis, spondylitis and psoriasis (PsO). [1]. Enthesitis is a key clinical feature of PsA with significant impact on function, quality of life and choice of treatment [2]. There are limited real-world studies on the characteristics of patients (pts) with PsA and enthesitits. Objectives To compare clinical characteristics of PsA pts with and without enthesitis. Methods 603 pts (M/F=278/326) with PsA according to CASPAR criteria were examined. Data was collected from 6 rheumatology clinics of the Russian Federation. Pts’ mean age 46.6±12.5 years (yrs.), PsA duration 9.7±7.1 yrs, PsO duration 20.45±13.0 yrs. Median (Me) DAPSA 25.5 [15.2; 41.8], body mass index (BMI) 27.5 [24.3; 31.2]. At baseline (BL) PsA activity by tender/swelling joint count (TJC)/68, (SJC)/66, enthesitis by LEI and plantar fascia, BSA (%), PASI, HAQ, DAPSA were evaluated. DAPSA&gt;28 indicate high disease activity (HDA). The one-factor model of logistic regression was used to identify a group of features that are associated with presence of enthesitis. M±SD, Me [Q25; Q75], Min-Max, %, t-test, Peаrson-χ 2 , Manna-Whitney tests, ORs with 95% CI were performed. All p&lt;0.05, were considered to indicate statistical significance. Results Enthesitis was found in 295 out of 603 pts (49%). Comparative analysis in both groups with and without enthesitis and one-factor model of logistic regression showed the following features at BL were associated with enthesitis: TJC&gt;5 (p=0.001), SJC&gt;3 (p=0.001), dactylitis (p=0.001), high disease activity by DAPSA (p=0.001), HAQ≥0.5 (p=0.001), BSA&gt;10% (p=0.001), nail PsO (p=0.003), CRP&gt;10 mg/l (p=0.018), BMI&gt;30 kg/m 2 (p=0.02). Pts with enthesitis had significantly more often depression (p=0.026), metabolic syndrome (p=0.047), fatty hepatosis (p=0.017), OR analysis with CI 95% for all parameters are shown on Figure 1. Figure 1. Factors associated with enthesitis in PsA pts. Conclusion In real clinical practice enthesitis was found in half of PsA pts. Enthesitis are associated with more severe peripheral arthritis, dactylitis, skin and nail PsO, higher PsA activity by DAPSA, worse quality of life and more likely to have depression, metabolic syndrome and fatty hepatosis. This should be considered for optimizing disease management strategy. References [1]Ogdie A, et al. J Rheumatol. 2021;48(5):698-706; doi:10.3899/jrheum.200371. [2]Mease PJ, et al . J Rheumatol. 2021;48(3):367–75; doi:10.3899/jrheum.191117. Acknowledgements The RU-PsART study group Disclosure of Interests Elena Loginova Speakers bureau: Janssen, Tatiana Korotaeva Speakers bureau: Pfizer, Novartis, MSD, AbbVie, Janssen, JSC BIOCAD, UCB, Lilly and Novartis-Sandoz, Consultant of: Pfizer, Novartis, MSD, AbbVie, Janssen, JSC BIOCAD, UCB, Lilly and Novartis-Sandoz, ELENA GUBAR: None declared, Yulia Korsakova Speakers bureau: Novartis, Svetlana Glukhova: None declared, Evgeny Nasonov: None declared, Valentina Sorotskaya: None declared, Irina Patrikeeva: None declared, Pavel Shesternya: None declared, Ivan Shchendrigin: None declared