tbuckley/cabot-search huggingface dataset:
Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer: final 10-year analysis of the open-label, single-arm, phase 2 APT trial
Authors: Sara M Tolaney, Paolo Tarantino, Noah Graham, Nabihah Tayob, Laia Parè, Guillermo Villacampa, Chau T Dang, Denise A Yardley, Beverly Moy, P Kelly Marcom, Kathy S Albain, Hope S Rugo, Matthew J Ellis, Iuliana Shapira, Antonio C Wolff, Lisa A Carey, Romualdo Barroso-Sousa, Patricia Villagrasa, Michelle DeMeo, Molly DiLullo, Jorge Gomez Tejeda Zanudo, Jakob Weiss, Nikhil Wagle, Ann H Partridge, Adrienne G Waks, Clifford A Hudis, Ian E Krop, Harold J Burstein, Aleix Prat, Eric P Winer
Journal: The Lancet Oncology (2023)
Metastases-directed stereotactic body radiotherapy in combination with targeted therapy or immunotherapy: systematic review and consensus recommendations by the EORTC–ESTRO OligoCare consortium
Authors: Stephanie G C Kroeze, Matea Pavic, Karin Stellamans, Yolande Lievens, Carlotta Becherini, Marta Scorsetti, Filippo Alongi, Umberto Ricardi, Barbara Alicja Jereczek-Fossa, Paulien Westhoff, Jasna But-Hadzic, Joachim Widder, Xavier Geets, Samuel Bral, Maarten Lambrecht, Charlotte Billiet, Igor Sirak, Sara Ramella, Ivaldi Giovanni Battista, Sergi Benavente, Almudena Zapatero, Fabiola Romero, Thomas Zilli, Kaouthar Khanfir, Hossein Hemmatazad, Berardino de Bari, Desiree N Klass, Shaukat Adnan, Heike Peulen, Juan Salinas Ramos, Michiel Strijbos, Sanjay Popat, Piet Ost, Matthias Guckenberger
Journal: The Lancet Oncology (2023)
Response-adapted omission of radiotherapy in children and adolescents with early-stage classical Hodgkin lymphoma and an adequate response to vincristine, etoposide, prednisone, and doxorubicin (EuroNet-PHL-C1): a titration study
Authors: Christine Mauz-Körholz, Judith Landman-Parker, Ana Fernández-Teijeiro, Andishe Attarbaschi, Walentyna Balwierz, Jörg M Bartelt, Auke Beishuizen, Sabah Boudjemaa, Michaela Cepelova, Francesco Ceppi, Alexander Claviez, Stephen Daw, Karin Dieckmann, Alexander Fosså, Stefan Gattenlöhner, Thomas Georgi, Lisa L Hjalgrim, Andrea Hraskova, Jonas Karlén, Lars Kurch, Thierry Leblanc, Georg Mann, Francoise Montravers, Jane Pears, Tanja Pelz, Vladan Rajić, Alan D Ramsay, Dietrich Stoevesandt, Anne Uyttebroeck, Dirk Vordermark, Dieter Körholz, Dirk Hasenclever, William H Wallace, Regine Kluge
Journal: The Lancet Oncology (2023)
Patient selection for urgent endoscopic retrograde cholangio-pancreatography by endoscopic ultrasound in predicted severe acute biliary pancreatitis (APEC-2): a multicentre prospective study
Authors: Nora D Hallensleben, Pauline M C Stassen, Nicolien J Schepers, Marc G Besselink, Marie-Paule G F Anten, Olaf J Bakker, Thomas L Bollen, David W da Costa, Sven M van Dijk, Hendrik M van Dullemen, Marcel G W Dijkgraaf, Brechje van Eijck, Casper H J van Eijck, Willemien Erkelens, Nicole S Erler, Paul Fockens, Erwin-Jan M van Geenen, Janneke van Grinsven, Wouter L Hazen, Robbert A Hollemans, Jeanin E van Hooft, Jeroen M Jansen, Frank J G M Kubben, Sjoerd D Kuiken, Alexander C Poen, Rutger Quispel, Rogier J de Ridder, Tessa E H Römkens, Erik J Schoon, Matthijs P Schwartz, Tom C J Seerden, Xavier J N M Smeets, B W Marcel Spanier, Adriaan C I T L Tan, Willem J Thijs, Robin Timmer, Devica S Umans, Niels G Venneman, Robert C Verdonk, Frank P Vleggaar, Wim van de Vrie, Roy L J van Wanrooij, Ben J Witteman, Hjalmar C van Santvoort, Stefan A W Bouwense, Marco J Bruno
Journal: Gut (2023)

Routine urgent endoscopic retrograde cholangiopancreatography (ERCP) with endoscopic biliary sphincterotomy (ES) does not improve outcome in patients with predicted severe acute biliary pancreatitis. Improved patient selection for ERCP by means of endoscopic ultrasonography (EUS) for stone/sludge detection may challenge these findings.
Diagnosis and management of complications from the treatment of primary central nervous system tumors in adults
Authors: Michael Weller, Emilie Le Rhun, Martin Van den Bent, Susan M Chang, Timothy F Cloughesy, Roland Goldbrunner, Yong-Kil Hong, Rakesh Jalali, Michael D Jenkinson, Giuseppe Minniti, Motoo Nagane, Evangelia Razis, Patrick Roth, Roberta Rudà, Ghazaleh Tabatabai, Patrick Y Wen, Susan C Short, Matthias Preusser
Journal: Neuro-Oncology (2023)

Abstract Central nervous system (CNS) tumor patients commonly undergo multimodality treatment in the course of their disease. Adverse effects and complications from these interventions have not been systematically studied, but pose significant challenges in clinical practice and impact function and quality of life, especially in the management of long-term brain tumor survivors. Here, the European Association of Neuro-Oncology (EANO) has developed recommendations to prevent, diagnose, and manage adverse effects and complications in the adult primary brain CNS tumor (except lymphomas) patient population with a specific focus on surgery, radiotherapy, and pharmacotherapy. Specifically, we also provide recommendations for dose adaptations, interruptions, and reexposure for pharmacotherapy that may serve as a reference for the management of standard of care in clinical trials. We also summarize which interventions are unnecessary, inactive or contraindicated. This consensus paper should serve as a reference for the conduct of standard therapy within and outside of clinical trials.
T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control
Authors: Maria M. Steele, Abhinav Jaiswal, Ines Delclaux, Ian D. Dryg, Dhaarini Murugan, Julia Femel, Sunny Son, Haley du Bois, Cameron Hill, Sancy A. Leachman, Young H. Chang, Lisa M. Coussens, Niroshana Anandasabapathy, Amanda W. Lund
Journal: Nature Immunology (2023)
The artificial sweetener erythritol and cardiovascular event risk
Authors: Marco Witkowski, Ina Nemet, Hassan Alamri, Jennifer Wilcox, Nilaksh Gupta, Nisreen Nimer, Arash Haghikia, Xinmin S. Li, Yuping Wu, Prasenjit Prasad Saha, Ilja Demuth, Maximilian König, Elisabeth Steinhagen-Thiessen, Tomas Cajka, Oliver Fiehn, Ulf Landmesser, W. H. Wilson Tang, Stanley L. Hazen
Journal: Nature Medicine (2023)
Multiomic analysis of homologous recombination-deficient end-stage high-grade serous ovarian cancer
Authors: Nikki L. Burdett, Madelynne O. Willis, Kathryn Alsop, Allison L. Hunt, Ahwan Pandey, Phineas T. Hamilton, Tamara Abulez, Xuan Liu, Therese Hoang, Stuart Craig, Sian Fereday, Joy Hendley, Dale W. Garsed, Katy Milne, Shreena Kalaria, Ashley Marshall, Brian L. Hood, Katlin N. Wilson, Kelly A. Conrads, Kathleen I. Pishas, Sumitra Ananda, Clare L. Scott, Yoland Antill, Orla McNally, Linda Mileshkin, Anne Hamilton, George Au-Yeung, Lisa Devereux, Heather Thorne, Andrea Bild, Nicholas W. Bateman, G. Larry Maxwell, Jeffrey T. Chang, Thomas P. Conrads, Brad H. Nelson, David D. L. Bowtell, Elizabeth L. Christie
Journal: Nature Genetics (2023)
Distinct dynamics of antigen-specific induction and differentiation of different CD11c+Tbet+ B-cell subsets
Authors: Juulke Steuten, Amélie V. Bos, Lisan H. Kuijper, Mathieu Claireaux, Wouter Olijhoek, George Elias, Mariel C. Duurland, Tineke Jorritsma, Casper Marsman, Alberta G.A. Paul, Juan J. Garcia Vallejo, Marit J. van Gils, Luuk Wieske, Taco W. Kuijpers, Filip Eftimov, S. Marieke van Ham, Anja ten Brinke
Journal: Journal of Allergy and Clinical Immunology (2023)

CD11c
Intranasal immunization with outer membrane vesicles (OMV) protects against airway colonization and systemic infection with Acinetobacter baumannii
Authors: Sophie L. Higham, Stephen Baker, Katie E. Flight, Aishwarya Krishna, Paul Kellam, Stephen T. Reece, John S. Tregoning
Journal: Journal of Infection (2023)

The multidrug-resistant bacteria Acinetobacter baumannii is a major cause of hospital-associated infection; a vaccine could significantly reduce this burden. The aim was to develop a clinically relevant model of A. baumannii respiratory tract infection and to test the impact of different immunization routes on protective immunity provided by an outer membrane vesicle (OMV) vaccine.BALB/c mice were intranasally challenged with isolates of oxa23-positive global clone GC2 A. baumannii from the lungs of patients with ventilator-associated pneumonia. Mice were immunized with OMVs by the intramuscular, subcutaneous or intranasal routes; protection was determined by measuring local and systemic bacterial load.Infection with A. baumannii clinical isolates led to a more disseminated infection than the prototype A. baumannii strain ATCC17978; with bacteria detectable in upper and lower airways and the spleen. Intramuscular immunization induced an antibody response but did not protect against bacterial infection. However, intranasal immunization significantly reduced airway colonization and prevented systemic bacterial dissemination.Use of clinically relevant isolates of A. baumannii provides stringent model for vaccine development. Intranasal immunization with OMVs was an effective route for providing protection, demonstrating that local immunity is important in preventing A. baumannii infection.
Association of Comprehensive Menthol Flavor Ban With Current Cigarette Smoking in Massachusetts From 2017 to 2021
Authors: Samuel Asare, Anuja Majmundar, Zheng Xue, Ahmedin Jemal, Nigar Nargis
Journal: JAMA Internal Medicine (2023)

This cross-sectional study compares self-reported smoking by adults before vs after prohibition of menthol-flavored cigarettes.
This Could Mean a True Tetrafascicular Intraventricular Block
Authors: Kjell Nikus, Juan Manzzardo, Andrés Ricardo Pérez-Riera
Journal: JAMA Internal Medicine (2023)

To the Editor We read with interest the case report by Dr Scheffer and colleagues.1 However, we find it necessary to make some comments about the report, including the interpretation of the electrocardiogram (ECG) findings.
Effect of an Intranasal Corticosteroid on Quality of Life and Local Microbiome in Young Children With Chronic Rhinosinusitis
Authors: Marta Latek, Piotr Łacwik, Katarzyna Molińska, Andrzej Błauż, Jakub Lach, Błażej Rychlik, Dominik Strapagiel, Joanna Majak, Joanna Molińska, Dorota Czech, Michał Seweryn, Piotr Kuna, Cezary Pałczyński, Paweł Majak
Journal: JAMA Pediatrics (2023)

Intranasal corticosteroids (INCs) remain the first-line treatment of chronic rhinosinusitis (CRS) in both adults and children, despite the lack of evidence regarding their efficacy in the pediatric population. Similarly, their effect on the sinonasal microbiome has not been well documented.
Assessment of US Federal Funding of Incarceration-Related Research, 1985 to 2022
Authors: Samantha J. Boch, Aaron W. Murnan, Jordan F. Pollard, Nichole L. Nidey, Rose Y. Hardy, Iheoma U. Iruka
Journal: JAMA Network Open (2023)

The US leads the world in the raw number of incarcerated persons as well as the rate of incarceration, with detrimental effects on individual-, family-, community-, and population-level health; as such, federal research has a critical role in documenting and addressing the health-related impacts of the US criminal legal system. How often incarceration-related research is funded at the National Institutes of Health (NIH), National Science Foundation (NSF), and US Department of Justice (DOJ) levels has a direct association with the public attention given to mass incarceration as well as the efficacy of strategies to mitigate negative effects and poor health related to incarceration.To understand how many incarceration-related projects have been funded at the NIH, NSF, and DOJ.This cross-sectional study used public historical project archives to search for relevant incarceration-related keywords (eg, incarceration, prison, parole) since January 1, 1985 (NIH and NSF), and since January 1, 2008 (DOJ). Quotations and Boolean operator logic were used. All searches and counts were conducted and double verified by 2 coauthors between December 12 and 17, 2022.Number and prevalence of funded projects related to incarceration and prison keywords.The term incarceration resulted in 3540 of 3 234 159 total project awards (0.11%) and prisoner-related terms resulted in 11 455 total project awards (0.35%) across the 3 federal agencies since 1985. Nearly a tenth of all projects funded at NIH since 1985 related to education (256 584 [9.62%]) compared with only 3373 projects (0.13%) that related to criminal legal or criminal justice or correctional system and 18 projects (0.0007%) that related to incarcerated parents. Only 1857 (0.07%) of all NIH-funded projects have been funded related to racism since 1985.This cross-sectional study found that a very low number of projects about incarceration have historically been funded at the NIH, DOJ, and NSF. These findings reflect a dearth of federally funded studies investigating the effects of mass incarceration or intervention strategies to mitigate adverse effects. Given the consequences of the criminal legal system, it is undoubtedly time for researchers, and our nation, to invest more resources into studying whether this system should be maintained, the intergenerational effects of mass incarceration, and strategies to best mitigate its impact on public health.
Time to End <i>Community Acquired</i> as an Adjectival Diagnosis for Pneumonia—Reply
Authors: Qinyuan Li, Yaolong Chen, Zhengxiu Luo
Journal: JAMA Pediatrics (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Time to End <i>Community Acquired</i> as an Adjectival Diagnosis for Pneumonia
Authors: Miles M. Weinberger
Journal: JAMA Pediatrics (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Association of Cardiovascular Health With Life Expectancy Free of Cardiovascular Disease, Diabetes, Cancer, and Dementia in UK Adults
Authors: Xuan Wang, Hao Ma, Xiang Li, Yoriko Heianza, JoAnn E. Manson, Oscar H. Franco, Lu Qi
Journal: JAMA Internal Medicine (2023)

The average life expectancy has increased substantially in the past few decades in most industrialized countries; however, not all of the increased life expectancy is being spent in optimal health, especially among individuals with low socioeconomic status.
This Could Mean a True Tetrafascicular Intraventricular Block—Reply
Authors: Matheus Kiszka Scheffer, Mariana Fuziy Nogueira De Marchi
Journal: JAMA Internal Medicine (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Integrating Alcohol-Related Prevention and Treatment Into Primary Care
Authors: Amy K. Lee, Jennifer F. Bobb, Julie E. Richards, Carol E. Achtmeyer, Evette Ludman, Malia Oliver, Ryan M. Caldeiro, Rebecca Parrish, Paula M. Lozano, Gwen T. Lapham, Emily C. Williams, Joseph E. Glass, Katharine A. Bradley
Journal: JAMA Internal Medicine (2023)

Unhealthy alcohol use is common and affects morbidity and mortality but is often neglected in medical settings, despite guidelines for both prevention and treatment.
Predicting the Survival of Patients With Cancer From Their Initial Oncology Consultation Document Using Natural Language Processing
Authors: John-Jose Nunez, Bonnie Leung, Cheryl Ho, Alan T. Bates, Raymond T. Ng
Journal: JAMA Network Open (2023)

Predicting short- and long-term survival of patients with cancer may improve their care. Prior predictive models either use data with limited availability or predict the outcome of only 1 type of cancer.To investigate whether natural language processing can predict survival of patients with general cancer from a patient's initial oncologist consultation document.This retrospective prognostic study used data from 47 625 of 59 800 patients who started cancer care at any of the 6 BC Cancer sites located in the province of British Columbia between April 1, 2011, and December 31, 2016. Mortality data were updated until April 6, 2022, and data were analyzed from update until September 30, 2022. All patients with a medical or radiation oncologist consultation document generated within 180 days of diagnosis were included; patients seen for multiple cancers were excluded.Initial oncologist consultation documents were analyzed using traditional and neural language models.The primary outcome was the performance of the predictive models, including balanced accuracy and receiver operating characteristics area under the curve (AUC). The secondary outcome was investigating what words the models used.Of the 47 625 patients in the sample, 25 428 (53.4%) were female and 22 197 (46.6%) were male, with a mean (SD) age of 64.9 (13.7) years. A total of 41 447 patients (87.0%) survived 6 months, 31 143 (65.4%) survived 36 months, and 27 880 (58.5%) survived 60 months, calculated from their initial oncologist consultation. The best models achieved a balanced accuracy of 0.856 (AUC, 0.928) for predicting 6-month survival, 0.842 (AUC, 0.918) for 36-month survival, and 0.837 (AUC, 0.918) for 60-month survival, on a holdout test set. Differences in what words were important for predicting 6- vs 60-month survival were found.These findings suggest that models performed comparably with or better than previous models predicting cancer survival and that they may be able to predict survival using readily available data without focusing on 1 cancer type.
Association of Hospice Profit Status With Family Caregivers’ Reported Care Experiences
Authors: Rebecca Anhang Price, Layla Parast, Marc N. Elliott, Anagha A. Tolpadi, Melissa A. Bradley, Danielle Schlang, Joan M. Teno
Journal: JAMA Internal Medicine (2023)

Expansive growth in the US hospice market has been driven almost exclusively by an increase in for-profit hospices. Prior research found that, in contrast to not-for-profit hospices, for-profit hospices focus on delivering care to patients in nursing homes, provide fewer nursing visits, and use less skilled staff. However, prior studies have not reported on the associations of these differences in care patterns with hospice care quality. Patient- and family-centeredness is a core element of hospice care quality that is measured through surveys of care experiences.
Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma
Authors: Tingting Liu, Juan Wang, Hongbo Yang, Qiushi Jin, Xiaotao Wang, Yihao Fu, Yu Luan, Qixuan Wang, Mark W. Youngblood, Xinyan Lu, Lucia Casadei, Raphael Pollock, Feng Yue
Journal: Cancer Research (2023)

Comprehensive profiling of the enhancer landscape and 3D genome structure in liposarcoma identifies extensive enhancer-oncogene coamplification and enhancer hijacking events, deepening the understanding of how oncogenes are regulated in cancer.