tbuckley/cabot-search huggingface dataset:
Exploring Discordance Between Patients and Clinicians—Understanding Perceived Disease Severity
Authors: John S. Barbieri, Karen MacDonald
Journal: JAMA Dermatology (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Toward the Next Generation of Neural Iontronic Interfaces
Authors: Csaba Forró, Simon Musall, Viviana Rincón Montes, John Linkhorst, Peter Walter, Matthias Wessling, Andreas Offenhäusser, Sven Ingebrandt, Yvonne Weber, Angelika Lampert, Francesca Santoro
Journal: Advanced Healthcare Materials (2023)

Neural interfaces are evolving at a rapid pace owing to advances in material science and fabrication, reduced cost of scalable complementary metal oxide semiconductor (CMOS) technologies, and highly interdisciplinary teams of researchers and engineers that span a large range from basic to applied and clinical sciences. This study outlines currently established technologies, defined as instruments and biological study systems that are routinely used in neuroscientific research. After identifying the shortcomings of current technologies, such as a lack of biocompatibility, topological optimization, low bandwidth, and lack of transparency, it maps out promising directions along which progress should be made to achieve the next generation of symbiotic and intelligent neural interfaces. Lastly, it proposes novel applications that can be achieved by these developments, ranging from the understanding and reproduction of synaptic learning to live-long multimodal measurements to monitor and treat various neuronal disorders.
A framework for assessing interactions for risk stratification models: the example of ovarian cancer
Authors: Minh Tung Phung, Alice W Lee, Karen McLean, Hoda Anton-Culver, Elisa V Bandera, Michael E Carney, Jenny Chang-Claude, Daniel W Cramer, Jennifer Anne Doherty, Renee T Fortner, Marc T Goodman, Holly R Harris, Allan Jensen, Francesmary Modugno, Kirsten B Moysich, Paul D P Pharoah, Bo Qin, Kathryn L Terry, Linda J Titus, Penelope M Webb, Anna H Wu, Nur Zeinomar, Argyrios Ziogas, Andrew Berchuck, Kathleen R Cho, Gillian E Hanley, Rafael Meza, Bhramar Mukherjee, Malcolm C Pike, Celeste Leigh Pearce, Britton Trabert
Journal: JNCI Journal of the National Cancer Institute (2023)

Abstract Generally, risk stratification models for cancer use effect estimates from risk/protective factor analyses that have not assessed potential interactions between these exposures. We have developed a 4-criterion framework for assessing interactions that includes statistical, qualitative, biological, and practical approaches. We present the application of this framework in an ovarian cancer setting because this is an important step in developing more accurate risk stratification models. Using data from 9 case-control studies in the Ovarian Cancer Association Consortium, we conducted a comprehensive analysis of interactions among 15 unequivocal risk and protective factors for ovarian cancer (including 14 non-genetic factors and a 36-variant polygenic score) with age and menopausal status. Pairwise interactions between the risk/protective factors were also assessed. We found that menopausal status modifies the association among endometriosis, first-degree family history of ovarian cancer, breastfeeding, and depot-medroxyprogesterone acetate use and disease risk, highlighting the importance of understanding multiplicative interactions when developing risk prediction models.
Prevalence of Atopic Diseases Among Sexually Diverse Adults in the US
Authors: Katelyn J. Rypka, Abel Woldu, Markus D. Boos, Sheilagh M. Maguiness, Matthew D. Mansh
Journal: JAMA Dermatology (2023)

This cross-sectional study assesses the prevalence of asthma, allergic rhinitis, or atopic dermatitis among sexually diverse adults compared with heterosexual adults in the US.
CTLA-4 Pathway Is Instrumental in Giant Cell Arteritis
Authors: Paul Régnier, Alexandre Le Joncour, Anna Maciejewski-Duval, Guillaume Darrasse-Jèze, Charles Dolladille, Wouter C. Meijers, Lisa Bastarache, Pierre Fouret, Patrick Bruneval, Floriane Arbaretaz, Célia Sayetta, Ana Márquez, Michelle Rosenzwajg, David Klatzmann, Patrice Cacoub, Javid J. Moslehi, Joe-Elie Salem, David Saadoun
Journal: Circulation Research (2023)

Giant cell arteritis (GCA) causes severe inflammation of the aorta and its branches and is characterized by intense effector T-cell infiltration. The roles that immune checkpoints play in the pathogenesis of GCA are still unclear. Our aim was to study the immune checkpoint interplay in GCA.First, we used VigiBase, the World Health Organization international pharmacovigilance database, to evaluate the relationship between GCA occurrence and immune checkpoint inhibitors treatments. We then further dissected the role of immune checkpoint inhibitors in the pathogenesis of GCA, using immunohistochemistry, immunofluorescence, transcriptomics, and flow cytometry on peripheral blood mononuclear cells and aortic tissues of GCA patients and appropriated controls.Using VigiBase, we identified GCA as a significant immune-related adverse event associated with anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein-4) but not anti-PD-1 (anti-programmed death-1) nor anti-PD-L1 (anti-programmed death-ligand 1) treatment. We further dissected a critical role for the CTLA-4 pathway in GCA by identification of the dysregulation of CTLA-4-derived gene pathways and proteins in CD4+ (cluster of differentiation 4) T cells (and specifically regulatory T cells) present in blood and aorta of GCA patients versus controls. While regulatory T cells were less abundant and activated/suppressive in blood and aorta of GCA versus controls, they still specifically upregulated CTLA-4. Activated and proliferating CTLA-4+ Ki-67+ regulatory T cells from GCA were more sensitive to anti-CTLA-4 (ipilimumab)-mediated in vitro depletion versus controls.We highlighted the instrumental role of CTLA-4 immune checkpoint in GCA, which provides a strong rationale for targeting this pathway.
Error in Figure
Journal: JAMA Dermatology (2023)

Álvaro Gómez-Tomás, MD; Jan Nico Bouwes Bavinck, MD, PhD; Roel Genders, MD, PhD; Carlos González-Cruz, MD; Estella de Jong, MD; Sarah Arron, MD, PhD; Vicente García-Patos, MD, PhD; Carla Ferrándiz-Pulido, MD, PhD
Association Between Syncope Trigger Type and Risk of Subsequent Life-Threatening Events in Patients With Long QT Syndrome
Authors: Arwa Younis, J. Martijn Bos, Wojciech Zareba, Mehmet K. Aktas, Arthur A. M. Wilde, Chadi Tabaja, Christopher Bodurian, Kathryn E. Tobert, Scott McNitt, Bronislava Polonsky, Wataru Shimizu, Michael J. Ackerman, Ilan Goldenberg
Journal: JAMA Cardiology (2023)

Syncope is the most powerful predictor for subsequent life-threatening events (LTEs) in patients with congenital long QT syndrome (LQTS). Whether distinct syncope triggers are associated with differential subsequent risk of LTEs is unknown.
Clinical and Pathological Spectrum of Prurigo Pigmentosa in Central European Individuals
Authors: Carina Michor-Tscharre, Lorenzo D’Alì, Carlo Cota, Regina Fink-Puches, Lorenzo Cerroni
Journal: JAMA Dermatology (2023)

Based on early studies, prurigo pigmentosa (PP) was considered a rare inflammatory dermatosis affecting primarily Asian individuals. However, several case reports subsequently showed that the disease is not restricted to those of Asian origin. Large studies on PP in central European individuals, on the other hand, are missing.
Complications and treatment errors related to regenerative periodontal surgery
Authors: Karin Jepsen, Anton Sculean, Søren Jepsen
Journal: Periodontology 2000 (2023)

Abstract Regenerative periodontal surgical procedures are an important component in the treatment of advanced periodontitis. They aim to improve the long‐term prognosis of teeth that are periodontally compromised by the presence of intrabony and/or furcation defects, resulting biologically in formation of root cementum, periodontal ligament, and alveolar bone and evidenced clinically by reduction of deep pockets to maintainable probing depths and/or improvements of vertical and horizontal furcation depth. Over the last 25 years, substantial clinical evidence has been accumulated to support the value of regenerative procedures in periodontally compromised dentitions. However, treatment success requires close attention to certain factors on the level of the patient, the tooth/defect, and the operator. Ignoring these factors in case selection, treatment planning, and treatment execution will increase the risk of complications that may jeopardize clinical success and may even be considered as treatment errors. Based on the currently available evidence from clinical practice guidelines, treatment algorithms, and on expert opinion, the present article provides an overview on the main factors, which influence the outcomes of regenerative periodontal surgery and gives recommendations on how to prevent complications and treatment errors.
Understanding Discordant Perceptions of Disease Severity Between Physicians and Patients With Eczema and Psoriasis Using Structural Equation Modeling
Authors: Valencia Long, Zhaojin Chen, Ruochen Du, Yiong Huak Chan, Yik Weng Yew, Hazel H. Oon, Steven Thng, Nur Qasrina Binte Iskandar Lim, Chris Tan, Nisha Suyien Chandran, Jose M. Valderas, Phillip Phan, Ellie Choi
Journal: JAMA Dermatology (2023)

Patients and physicians often have differing opinions on the patient's disease severity. This phenomenon, termed discordant severity grading (DSG), hinders the patient-physician relationship and is a source of frustration.
Improved long‐term survival with tafamidis treatment in patients with transthyretin amyloid cardiomyopathy and severe heart failure symptoms
Authors: Perry Elliott, Balarama Gundapaneni, Marla B. Sultan, Monica Ines, Pablo Garcia‐Pavia
Journal: European Journal of Heart Failure (2023)

The value of disease-modifying therapies (such as tafamidis) in patients with transthyretin amyloid cardiomyopathy (ATTR-CM) and severe heart failure symptoms has been debated. This study assessed long-term all-cause survival in patients with New York Heart Association (NYHA) class III symptoms in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT) long-term extension (LTE) study.At the baseline of ATTR-ACT, 55/176 (31.3%) patients receiving tafamidis 80 mg and 63/177 (35.6%) receiving placebo had NYHA class III symptoms. After 30 months of treatment, patients could join an ongoing LTE study to receive open-label tafamidis. In an interim analysis of the LTE study (August 2021), all-cause mortality was lower among patients with NYHA class III symptoms who received continuous tafamidis in ATTR-ACT and the LTE study (hazard ratio 0.64; 95% confidence interval 0.41-0.99; median follow-up: 60 months), as compared with those who received placebo in ATTR-ACT and tafamidis in the LTE study (median follow-up: 56 months). Similar findings were observed in patients with NYHA class I/II symptoms at baseline (0.50; 0.35-0.73; tafamidis 80 mg n = 121; placebo n = 114; median follow-up of 61 and 60 months, respectively).We observed reduced all-cause mortality with continuous tafamidis treatment compared with delayed tafamidis treatment (placebo then tafamidis) in patients with NYHA class III symptoms at baseline over a median follow-up of ∼5 years. These findings demonstrate the value of tafamidis treatment in patients with ATTR-CM and severe heart failure symptoms, and emphasize the importance of early treatment.ClinicalTrials.gov NCT01994889 and NCT02791230.
CDC: RSV Vaccine Recommended for Older People
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Subcortical Brain Alterations in Carriers of Genomic Copy Number Variants
Authors: Kuldeep Kumar, Claudia Modenato, Clara Moreau, Christopher R.K. Ching, Annabelle Harvey, Sandra Martin-Brevet, Guillaume Huguet, Martineau Jean-Louis, Elise Douard, Charles-Olivier Martin, Nadine Younis, Petra Tamer, Anne M. Maillard, Borja Rodriguez-Herreros, Aurélie Pain, Leila Kushan, Dmitry Isaev, Kathryn Alpert, Anjani Ragothaman, Jessica A. Turner, Lei Wang, Tiffany C. Ho, Lianne Schmaal, Ana I. Silva, Marianne B.M. van den Bree, David E.J. Linden, Michael J. Owen, Jeremy Hall, Sarah Lippé, Guillaume Dumas, Bogdan Draganski, Boris A. Gutman, Ida E. Sønderby, Ole A. Andreassen, Laura M. Schultz, Laura Almasy, David C. Glahn, Carrie E. Bearden, Paul M. Thompson, Sébastien Jacquemont
Journal: American Journal of Psychiatry (2023)

Copy number variants (CNVs) are well-known genetic pleiotropic risk factors for multiple neurodevelopmental and psychiatric disorders (NPDs), including autism (ASD) and schizophrenia. Little is known about how different CNVs conferring risk for the same condition may affect subcortical brain structures and how these alterations relate to the level of disease risk conferred by CNVs. To fill this gap, the authors investigated gross volume, vertex-level thickness, and surface maps of subcortical structures in 11 CNVs and six NPDs.
Serial N-Terminal Pro–B-Type Natriuretic Peptide Measurements in the Population Without Clinical Heart Failure—Reply
Authors: Mahmoud Al Rifai, Xiaoming Jia, Vijay Nambi
Journal: JAMA Cardiology (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
miR-32-5p induces hepatic steatosis and hyperlipidemia by triggering de novo lipogenesis
Authors: Ya-Di Wang, Liang-Liang Wu, Yun-Ni Mai, Kai Wang, Yi Tang, Qi-Yu Wang, Jiao-Yang Li, Li-Yan Jiang, Zhe-Zhen Liao, Can Hu, Yuan-Yuan Wang, Jing-Jing Liu, Jiang-Hua Liu, Xin-Hua Xiao
Journal: Metabolism (2023)
Renal Replacement Therapy in a World of Constraints: Lessons from the COVID-19 Pandemic
Authors: Stephane Gaudry, Khalil Chaïbi, Didier Dreyfuss
Journal: American Journal of Respiratory and Critical Care Medicine (2023)

"Renal Replacement Therapy in a World of Constraints: Lessons from the COVID-19 Pandemic." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
BRAF–MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas
Authors: Priscilla K. Brastianos, Erin Twohy, Susan Geyer, Elizabeth R. Gerstner, Timothy J. Kaufmann, Shervin Tabrizi, Brian Kabat, Julia Thierauf, Michael W. Ruff, Daniela A. Bota, David A. Reardon, Adam L. Cohen, Macarena I. De La Fuente, Glenn J. Lesser, Jian Campian, Pankaj K. Agarwalla, Priya Kumthekar, Bhupinder Mann, Shivangi Vora, Michael Knopp, A. John Iafrate, William T. Curry, Daniel P. Cahill, Helen A. Shih, Paul D. Brown, Sandro Santagata, Fred G. Barker, Evanthia Galanis
Journal: New England Journal of Medicine (2023)

Craniopharyngiomas, primary brain tumors of the pituitary-hypothalamic axis, can cause clinically significant sequelae. Treatment with the use of surgery, radiation, or both is often associated with substantial morbidity related to vision loss, neuroendocrine dysfunction, and memory loss. Genotyping has shown that more than 90% of papillary craniopharyngiomas carry
Platelet Rich Plasma Loaded Multifunctional Hydrogel Accelerates Diabetic Wound Healing via Regulating the Continuously Abnormal Microenvironments
Authors: Kui Xu, Sijie Deng, Yabin Zhu, Wei Yang, Weizhen Chen, Liang Huang, Chi Zhang, Ming Li, Lijiao Ao, Yibo Jiang, Xiangyu Wang, Qiqing Zhang
Journal: Advanced Healthcare Materials (2023)

Continuous oxidative stress and cellular dysfunction caused by hyperglycemia are distinguishing features of diabetic wounds. It has been a great challenge to develop a smart dressing that can accelerate diabetic wound healing through regulating abnormal microenvironments. In this study, a platelet rich plasma (PRP) loaded multifunctional hydrogel with reactive oxygen species (ROS) and glucose dual-responsive property is reported. It can be conveniently prepared with PRP, dopamine (DA) grafted alginate (Alg-DA), and 6-aminobenzo[c][1,2]oxaborol-1(3H)-ol (ABO) conjugated hyaluronic acid (HA-ABO) through ionic crosslinks, hydrogen-bond interactions, and boronate ester bonds. The hydrogel possesses injectability, moldability, tissue adhesion, self-healing, low hemolysis, and hemostasis performances. Its excellent antioxidant property can create a low oxidative stress microenvironment for other biological events. Under an oxidative stress and/or hyperglycemia state, the hydrogel can degrade at an accelerated rate to release a variety of cytokines derived from activated blood platelets. The result is a series of positive changes that are favorable for diabetic wound healing, including fast anti-inflammation, activated macrophage polarization toward M2 phenotype, promoted migration and proliferation of fibroblasts, as well as expedited angiogenesis. This work provides an efficient strategy for chronic diabetic wound management and offers an alternative for developing a new-type PRP-based bioactive wound dressing.
A Novel Strategy to Improve Tumor Targeting of Hydrophilic Drugs and Nanoparticles for Imaging Guided Synergetic Therapy
Authors: Taoxia Liu, Chang Guo, Suying Xu, Gaofei Hu, Leyu Wang
Journal: Advanced Healthcare Materials (2023)

The fast renal clearance of hydrophilic small molecular anticancer drugs and ultrasmall nanoparticles (NPs) results in the low utilization rate and certain side effects, thus improving the tumor targeting is highly desired but faces great challenges. A novel and general β-cyclodextrin (CD) aggregation-induced assembly strategy to fabricate doxorubicin (DOX) and CD-coated NPs (such as Au) co-encapsulated pH-responsive nanocomposites (NCs) is proposed. By adding DOX×HCl and reducing pH in a reversed microemulsion system, hydrophilic CD-coated AuNPs rapidly assemble into large NCs. Then in situ polymerization of dopamine and sequentially coordinating with Cu2+ on the surface of NCs provide extra weak acid responsiveness, chemodynamic therapy (CDT), and improved biocompatibility as well as stability. The subsequent tumor microenvironment responsive dissociation notably improves their passive tumor targeting, bioavailability, imaging, and therapeutic capabilities, as well as facilitates their internalization by tumor cells and metabolic clearance, thereby reducing side effects. The combination of polymerized dopamine and assembled AuNPs reinforces photothermal capability, thus further boosting CDT through thermally amplifying Cu-catalyzed Fenton-like reaction. Both in vitro and in vivo studies confirm the desirable outcomes of these NCs as photoacoustic imaging guided trimodal (thermally enhanced CDT, photothermal therapy, and chemotherapy) synergistic tumor treatment agents with minimal systemic toxicity.
Prospective Analysis of Immunosuppressive Therapy in Cardiac Sarcoidosis With Fluorodeoxyglucose Myocardial Accumulation
Authors: Ryota Morimoto, Kazumasa Unno, Naotoshi Fujita, Yasuhiro Sakuragi, Takuya Nishimoto, Masato Yamashita, Tasuku Kuwayama, Hiroaki Hiraiwa, Toru Kondo, Yachiyo Kuwatsuka, Takahiro Okumura, Satoru Ohshima, Hiroshi Takahashi, Masahiko Ando, Hideki Ishii, Katsuhiko Kato, Toyoaki Murohara
Journal: JACC. Cardiovascular imaging (2023)
Precision Oncology for Papillary Craniopharyngioma
Authors: Jaishri O. Blakeley, Kevin Shannon
Journal: New England Journal of Medicine (2023)

Papillary craniopharyngiomas are ultra-rare tumors of the central nervous system (CNS), with fewer than 600 new cases per year in the United States. These tumors most commonly occur in children 5 to 14 years of age and adults older than 50 years of age. They grow from embryonic cells near the stalk of the pituitary gland.1 Because of this anatomic location abutting the optic nerve, pituitary gland, and third ventricle, complete surgical excision is rarely feasible. Radiation therapy is similarly associated with short- and long-term complications and variable efficacy. Thus, although papillary craniopharyngiomas are histologically benign, the natural history of . . .
Beneficial Effects of Ketone Ester in Patients With Cardiogenic Shock
Authors: Kristoffer Berg-Hansen, Kristian Hylleberg Christensen, Nigopan Gopalasingam, Roni Nielsen, Hans Eiskjær, Niels Møller, Thomas Birkelund, Steffen Christensen, Henrik Wiggers
Journal: JACC Heart Failure (2023)