tbuckley/cabot-search huggingface dataset:
Human Physiology
Journal: JAMA (1952)

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ARTIFICIAL PRODUCTION OF NORMAL LARVAE FROM THE UNFERTILIZED EGGS OF THE SEA URCHIN.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coronary disease and competitiveness.
Journal: BMJ (1969)

PointersPropranolol in Hypertension: Clinical trial shows its potency is similar to other commonly used hypotensive drugs.Advantages are absence of postural and exercise hypotension and good control of supine blood pressure (p. 7).Salicylate Poisoning: Report of successful management of 10 adults with sodium bicarbonate and acetazolamide (p.16).Case treated by forced alkaline diuresis (p.35).Leader at p. 3. Bone Metastases: Strontium-85 scanning found to be useful adjunct in differential diagnosis of malignant and other lesions of bone (p.19).Post-thyroidectomy Hypoparathyroidism: Post- partum hypercalcaemia reported, persisting for several months (p.23).Chronic Heart Block: Results of conservative treatment with oral long-acting isoprenaline.One-, two-, and three-year survival rates were respectively 76%, 64%, and 57%.About half required pacing (p.26).Asymptomatic Urinary Infections: In women attending a gynaecological outpatient depart- ment.High proportion had radiological abnormalities (p.29).Salbutamol in Asthma: Unlike other broncho- dilators this new drug has little effect on cardio- vascular system (p.31).Cigarette and Cigar Smoke: Cause proliferation of goblet cells in bronchial tree of the rat (p.33).Coronary Artery Disease: Management dis- cussed in "Medicine Today" article (p. 38).Leader at this page on aetiological role of " competitiveness."Vitamin A: In Today's Drugs (p.38).
JAMA 100 Years Ago
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erythrocyte Sedimentation in Anaemia
Authors: R. Terry
Journal: BMJ (1952)

OBJECTIVE: Evaluation of a complex and variable disease such as rheumatoid arthritis (RA) poses a challenge particularly over the medium to long term. A practical framework to evaluate clinically relevant outcomes over the long term is the "5D" approach of Fries, described in 1980. We describe the 20 year outcome in 52 survivors of a 123 patient cohort in terms of change in discomfort, disability, drug side effects, dollar costs, and deaths. METHODS: We studied 123 patients with RA allocated to their first disease modifying antirheumatic drug (DMARD) between 1977 and 1979. All were under the overall care of one physician over the 20 years and were maintained where possible taking a single DMARD. Baseline demographic variables, the Ritchie Articular Index (RAI), Lee functional index, and erythrocyte sedimentation rate (ESR) were initially recorded. The extent to which the demographic and disease variables contributed to need for joint replacement surgery was assessed. Therapies for comorbidity were also documented. RESULTS: At cohort inception mean age was 50 years, RAI was 35, and median disease duration 5.5 years. F:M ratio was 90:33; 96% of patients were positive for rheumatoid factor (RF). Initial median ESR was 55 mm/h. At 20 years, 9 patients (7% of original cohort, 14% of survivors) were lost to followup and 62 (50%) had died. In the 52 survivors RAI, a surrogate for disability, showed a significant improvement (p &lt; 0.0001), but disability measured by Lee functional index showed a deterioration (p = 0.018); 50% underwent joint replacement surgery. Initial ESR and mean ESR over the first 10 years of followup were significantly higher in those who required surgery. Nonsteroidal antiinflammatory drug (NSAID) use declined, but at least 2 deaths and 4 renal deaths that may have been related to therapy were attributed to NSAID use. No unexpected DMARD toxicity or mortality occurred. Concomitant therapy for comorbidity, in particular for cardiovascular disease, osteoporosis, and gastrointestinal disease, increased: more than 60% were on these therapies at 20 year followup. CONCLUSION: Strategies to improve the outcome of RA in all dimensions should include: earlier referral for expert assessment; avoidance of NSAID gastrointestinal and nephrotoxicity; a more intensive effort to identify effective management of comorbidity and those likely to have a poor outcome. Such patients require sustained, intensive therapy to minimize later disability.
Evaluation of a new mumps vaccine. Mumps virus vaccine, live, attenuated (Mumpsvax)
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contents
Authors: Joan Cordona, R Esteban, S Zeuzem, R Demasi, A Baldini, B Coate, D Luo, J Mrus, J Witek, H Innes, D Goldberg, G Dusheiko, P Hayes, P Mills, J Dillon, E Aspinall, S Barclay, S Hutchinson, C.-H Chen, C.-L Lin, T.-H Hu, C.-H Hung, P.-L Tseng, J.-H Wang, J.-Y Chang, S.-N Lu, R.-N Chien, C.-M Lee, P Schwabl, B Payer, J Grahovac, S Klein, T Horvatits, M Mitterhauser, J Stift, Y Boucher, J Trebicka, M Trauner, B Angermayr, V Fuhrmann, T Reiberger, M Peck-Radosavljevic, I Eickmeier, D Seidel, J Gru ¨n, K Derkow, S Lehnardt, A Ku, A Hamann, E Schott, F Durand, S Buyse, C Francoz, C Laoue, O Bruno, J Belghiti, R Moreau, V Vilgrain, D Valla, A Colecchia, A Colli, G Casazza, D Mandolesi, R Schiumerini, L Reggiani, G Marasco, M Taddia, A Lisotti, G Mazzella, A Di Biase, R Golfieri, M Pinzani, D Festi, A Vitale, A Cucchetti, G Qiao, M Cescon, J Li, R Morales, A Frigo, Y Xia, F Tuci, F Shen, U Cillo, A Pinna
Journal: Journal of Hepatology (2014)
Educational Programs in US Medical Schools
Authors: Harry S. Jonas
Journal: JAMA (1991)

Historical review of the medical education issues of<i>JAMA</i>, first published in 1901, allows us to identify decades of intense change interspersed with periods of relative stability. The 1960s was a decade of rapid growth and expansion in response to a then national priority— increasing the number of physicians in the United States. The number of medical schools grew from 86 in the 1960-1961 academic year to 103 in 1970-1971, and the entering class size increased from 8298 to 11 348. This growth continued during the 1970s, and by the 1980-1981 academic year there were 126 medical schools and 17204 entering students. To support this explosive growth, various liaison committees responsible for the accreditation of medical education were redesigned. Also associated with the expansion of medical education during the late 1960s and early 1970s was an intense burst of curricular innovation. By 1980, the growth phase was flattening, and governmental
<i>Erratum</i>: Vol. 65, No. 10
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

In the report, "Human Rabies - Missouri, 2014," on page 255, the second sentence of the first full paragraph should read as follows: "The rabies variant associated with this bat species occasionally infects other bats (e.g., Tadarida braziliensis [Mexican free-tailed bat]) as well as cats, foxes, and other species."
Spinal subdural hematoma: a possible hazard of lumbar puncture in an alcoholic
Authors: D. Dunn
Journal: JAMA (1979)

A RARE, but serious, complication of lumbar puncture is the production of a spinal subdural hematoma with resulting damage to the cord and roots. The importance of thrombocytopenia, usually associated with malignancy, in the formation of these hematomas was emphasized in a recent review in which it was present in nine of 12 patients.<sup>1</sup>Alcoholism, a common problem, can cause thrombocytopenia,<sup>2</sup>and in a chronic alcoholic can be an unsuspected hazard of lumbar puncture, as in the patient described in this report. <h3>Report of a Case</h3> A severely debilitated, 37-year-old female alcoholic was admitted to the hospital because of fever, heart murmur, tetany, and tremulousness. No history or clinical evidence of a blood dyscrasia was noted. The prothrombin time and the partial thromboplastin time were normal. After admission, she had a cardiac arrest but was successfully resuscitated. She was lethargic and disoriented, and because of the possibility of
Thank You, &lt;emph type="ital"&gt;JAMA&lt;/emph&gt; Peer Reviewers and Authors
Authors: Phil B. Fontanarosa
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HEREDITARY TRANSFORMATION IN FICTION.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Polycyclic Aromatic Hydrocarbon Metabolites in Urine as Biomarkers of Exposure and Effect
Authors: Paul Strickland, Daehee Kang, Pornchai Sithisarankul
Journal: Environmental Health Perspectives (1996)

Humans are exposed to polycyclic aromatic hydrocarbons (PAHs) from various occupational, environmental, medicinal, and dietary sources.PAH metabolites in human urine can be used as biomarkers of internal dose to assess recent exposure to PAHs.PAH metabolites that have been detected in human urine include 1-hydroxypyrene (1-OHP), 1-hydroxypyrene-O-glucuronide (1 -OHP-gluc), 3-hydroxybenzo[alpyrene, 7,8,9,1 0-tetrahydroxy-7,8,9, 1 0-tetrahydrobenzo[alpyrene, and a number of other hydroxylated PAHs.The most widely used of these is l-OHP-gluc, the major form of 1-OHP in human urine, by virtue of its relatively high concentration and prevalence in urine and its ease of measurement.This metabolite of pyrene can be measured as 1-OHP after deconjugation of the glucuronide with P-glucuronidase or directly as 1-OHP-gluc without deconjugation.Elevated levels of 1-OHP or 1-OHP-gluc have been demonstrated in smokers (versus nonsmokers), in patients receiving coal tar treatment (versus pretreatment), after workshifts in road pavers (versus before shifts or versus controls), after shifts in coke oven work- ers (versus before shift), and in subjects ingesting charbroiled meat (versus preingestion).More importantly, this metabolite is found (at low levels) in most human urine, even in persons without apparent occupational or smoking exposure.Although measurement of these metabolites is useful in assessing recent exposure to PAHs, their value as predictive markers of biological effect or health outcomes has not been rigorously tested and at present can only be inferred by association.
Access to Health Care
Authors: Cosimo N. Storniolo
Journal: Annals of Internal Medicine (1993)

Letters1 February 1993Access to Health CareCosimo N. Storniolo, MDCosimo N. Storniolo, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-3-199302010-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:“What kind of insurance does she have?” asked the orthopedist's office secretary. The question was both forthright and expected. “Does it matter?” I queried, as I struggled to get my patient a necessary consultation. But I knew the reality that Medicaid and uninsured patients go to clinics, not private offices to see residents (like myself). They wait in large, impersonal rooms for their name to be bellowed through the door or over a loudspeaker. Their referral delay is 2 to 3 months, not 2 to 3 weeks. When they have an acute problem, they may be put ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1993Volume 118, Issue 3Page: 232-235KeywordsDrugsElderlyHealth careHealth insuranceLiver transplantationPopulation statisticsSurgery ePublished: 15 August 2000 Issue Published: 1 February 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
An in vivo assessment of factor VIII concentrates
Authors: G. Rock
Journal: JAMA (1985)

Replacement therapy for patients with hemophilia A requires that a specific dose of factor VIII be administered. Generally, these calculations involve the use of the manufacturer's stated dose in an equation. We have assessed factor VIII concentrates by in vitro techniques and found a considerable discrepancy (35%) between the stated and the measured contents. Confirmation of this discrepancy was obtained by in vivo assessment where posttransfusion recoveries corresponded to the measured rather than the stated contents of the vial. The half-disappearance time ranged from five to eight hours. The data suggest that constant monitoring of factor VIII preparations is necessary to ensure optimal treatment of patients with hemophilia A and help to explain the recent efforts by the Office of Biologics to achieve standardization. (<i>JAMA</i>1985;254:777-780)
Preventive Effect of β-Adrenoceptor Blockade on Glucocorticoid-Induced Memory Retrieval Deficits
Authors: Dominique de Quervain
Journal: American Journal of Psychiatry (2007)

Objective: Elevated glucocorticoid levels impair retrieval of emotional information, and animal studies indicate that this effect depends on concurrent emotional arousal-induced increases in noradrenergic transmission within the brain. The authors investigated whether the β-adrenoceptor antagonist propranolol blocks glucocorticoid-induced memory retrieval impairments in human subjects. Method: In a double-blind, placebo-controlled study, 42 healthy volunteers were presented a set of words with variable emotionality and asked to learn them for recall. A day later, cortisone (25 mg), propranolol (40 mg), or both drugs were administered orally 1 hour before a free-recall test. Results: Cortisone selectively impaired the recall of emotionally arousing words by 42%. This impairment was blocked by the concurrent administration of propranolol. Propranolol alone did not affect recall of either emotional or neutral words. Conclusions: A pharmacological blockade of β-adrenoceptors prevents glucocorticoid-induced memory retrieval deficits in human subjects. This finding may have important implications for the treatment of memory deficits in hypercortisolemic states, such as stress and depression.
Drug-related superinfection in hospitalized patients
Authors: A. M. Walker
Journal: JAMA (1979)

In a series of 14,077 hospitalized medical patients receiving antibiotics, superinfection developed in 95 (0.7%) during drug therapy. The majority were yeast and fungal infections, and serious infections occurred with a frequency of less than one per 1,000 patients treated. Concurrent immunosuppression and impaired renal function increased the risk of new infections. (<i>JAMA</i>242:1273-1275, 1979)
Correction to: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance
Authors: Tao Zhang, Rong Qu, Shingpan Chan, Mengzhen Lai, Linjiang Tong, Fang Feng, Hongyu Chen, Tingting Song, Peiran Song, Gang Bai, Yingqiang Liu, Yanan Wang, Yan Li, Yi Su, Yanyan Shen, Yiming Sun, Yi Chen, Meiyu Geng, Ke Ding, Jian Ding, Hua Xie
Journal: Molecular Cancer (2021)
Herbal medicine Sho-saiko-to (TJ-9) prevent liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient l-amino acid-defined diet
Authors: Isao Sakaida, Yasuhiro Matsumura, Shinta Akiyama, Koji Hayashi, Atsushi Ishige, Kiwamu Okita
Journal: Journal of Hepatology (1998)
Progress Toward Poliomyelitis Eradication—Pakistan and Afghanistan, January 2005–May 2006
Journal: JAMA (2006)

As of March 2006, wild poliovirus (WPV) remained indigenous in four countries: Afghanistan, India, Nigeria, and Pakistan. Since 2005, WPV-endemic countries in Asia have intensified their polio eradication measures through use of type 1 monovalent oral polio vaccine (mOPV1) and implementation of innovative social mobilization, communication, and vaccine-delivery strategies. This report describes polio eradication strategies in Afghanistan and Pakistan during January 2005-May 2006.
Ischemia-reperfusion attenuates upregulation of flk-1 in myocardial infarction Christian Zellner, Phuljhuri Chakraborti, Richard E. Sievers, Kanu Chatterjee, William Grossman, Randall J. Lee. University of California, San Francisco, San Francisco, CA
Journal: Journal of the American College of Cardiology (2001)
Effects of L-asparaginase in acute myelocytic leukemia
Authors: T. Ohnuma
Journal: JAMA (1969)

A man with acute myelocytic leukemia was induced into complete remission after a single injection of L-asparaginase 1,000 international units/kg body weight. Nausea, vomiting, fever, weight loss, muscle wasting, hepatic impairment, pancreatitis, hypoinsulinemia, hyperglycemia, fibrinogenopenia, hypocholesterolemia, malabsorption syndrome, and acute brain dysfunctional syndrome developed. These phenomena of L-asparaginase toxicity can be interpreted as induced asparagine deficiency. A "rescue" infusion of L-asparagine was attempted. After relapse eight months later, the patient again attained remission from L-asparaginase.