tbuckley/cabot-search huggingface dataset:
Use of the Internet for Health Information and Communication
Authors: Joshua Fogel
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SUPPRESSION OF DIPHTHERIA.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Illness and indignity
Authors: T. S. Szasz
Journal: JAMA (1974)

ALL OF us in the health professions share certain fundamental aspirations and goals, among which the most important ones are keeping the healthy person healthy; restoring the sick person to health; and, most generally, safeguarding and prolonging life. That these ends are so overwhelmingly good and noble is what makes their pursuit so gratifying, and those in the health professions so richly honored and rewarded. Life would be simpler than it is if health and longevity were its only, or even its principal, purposes; or, to put it differently, if there were no goals or values that often conflict with their pursuit. One of the values that men and women—and children, too—cherish, and that often conflicts with their pursuit of health at any cost, is dignity. Dignity is, of course, that ineffable and yet obvious quality of human encounters and situations that enriches the participants' self-esteem. For example, in these
Error in Abstract
Authors: Stephanie Winkelbeiner, Philipp Homan, Ramesh Raghavan
Journal: JAMA Psychiatry (2020)

Kristine L. Rae Olmsted, MSPH; Michael Bartoszek, MD; Sean Mulvaney, MD; Brian McLean, MD; Ali Turabi, MD; Ryan Young, MD; Eugene Kim, MD; Russ Vandermaas-Peeler, MS; Jessica Kelley Morgan, PhD; Octav Constantinescu, MD; Shawn Kane, MD; Cuong Nguyen, MD; Shawn Hirsch, MPH; Breda Munoz, PhD; Dennis Wallace, PhD; Julie Croxford, BSN, MPH; James H. Lynch, MD; Ronald White, MD; Bradford B. Walters, MD, PhD
Myocardial ischemia associated with transtracheal aspiration
Authors: J. C. Pitts
Journal: JAMA (1977)

ACCURATE interpretation of cultures of expectorated secretions is frequently impossible because such material contains microorganisms from the mouth and not present in the lower respiratory tract. Numerous studies have documented the value of transtracheal aspiration in identifying pathogens from the lower respiratory tract, and although all have stressed its safety,<sup>1</sup>occasional serious morbidity or even mortality has been noted.<sup>2</sup>We describe a patient in whom myocardial ischemia occurred during transtracheal aspiration and call attention to the importance of adequate oxygenation for patients having this procedure. <h3>Report of a Case</h3> A 52-year-old hypertensive man was readmitted to the hospital 20 days after right pneumonectomy for squamous cell carcinoma because of progressive shortness of breath, five-pillow orthopnea, and paroxysmal nocturnal dyspnea. Rales were present over the left lung base; an S3 gallop was heard, but otherwise there were no signs of heart failure. His electrolyte and BUN levels were within
Handbook for Attendants on the Insane, with an appendix giving the Regulations for the Training and Examination of Candidates for the Certificate of Proficiency in Nursing of the Medico-Psychological Association of Great Britain and Ireland. Fourth Edition.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Obituary
Authors: David M. Mitchell
Journal: British Journal of Dermatology (1978)

Journal Article Obituary Get access David M. Mitchell David M. Mitchell Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 99, Issue 1, 1 July 1978, Page 111, https://doi.org/10.1111/j.1365-2133.1978.tb01969.x Published: 01 July 1978
Special considerations for minority participation in prenatal diagnosis
Authors: R. F. Murray
Journal: JAMA (1980)

Parents who use information from prenatal diagnosis in family planning may be faced with difficult decisions. For a variety of reasons, the communications and decision-making process may be substantially more complex and difficult if the parents are members of a minority group. Unless a number of special considerations are kept in mind when programs of prenatal diagnosis for minorities are developed, such programs may be more harmful than beneficial. (<i>JAMA</i>243:1254-1256, 1980)
How well has Canada contained the costs of doctoring?
Authors: J. S. Hughes
Journal: JAMA (1991)

Canada's provinces have had varying success at containing the costs of physician services through the use of fee schedules and expenditure targets. This article examines the wide variation in the increases in the costs of physician services among Ontario, Quebec, and British Columbia between 1975 and 1987. Cost increases during that time resulted from various combinations of increases in prices (fees) and utilization, stimulated by an increased supply of physicians. Differences among the three provinces resulted from differences in the aggressiveness of fee schedule controls and whether expenditure targets were imposed. Regardless of the degree of expenditure increases, utilization increased steadily in all three provinces and was associated most consistently with growth in the supply of physicians. This was most dramatically illustrated in Quebec, which noted the most rapid rise in physician-to-population ratio. Cost containment may ultimately require constraints on the number of new physicians in addition to controls on fees and utilization. (<i>JAMA</i>. 1991;265:2347-2351)
Afibrinogenemia and Thrombocytopenia in Guinea Pigs Following Injection of Echis Colorata Venom
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Facing the challenge: Novel treatment options for patients with myelodysplastic syndromes
Authors: Anne Sophie Kubasch, Uwe Platzbecker
Journal: HemaSphere (2018)

1Medical Clinic and Policlinic I, University Hospital Carl Gustav Carus, TU Dresden 2National Center for Tumor Diseases (NCT), University Hospital Carl Gustav Carus, TU Dresden 3German Cancer Consortium (DKTK), Dresden 4German Cancer Research Center (DKFZ), Heidelberg, Germany This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
Cadmium uptake and metabolism in cultured cells
Authors: A Glennås, H E Rugstad
Journal: Environmental Health Perspectives (1984)

Cultured cells have been made resistant to otherwise lethal concentrations of the toxic Cd ion, probably by induction of metallothionein (MT) synthesis and binding of Cd to the MT.One human epithelial cell line (HE) and two enzyme-deficient mutants of mouse fibroblasts (Lcells) (Cl 1D and A9) and their Cd-resistant substrains with a high content of MT, have been used to study cellular Cd uptake and metabolism.For cell survival of "wild type" cells, the critical level of intracellular Cd is determined to be around 6 nmole Cd/mg cell protein.Resistant cells can tolerate Cd levels several times above this concentration, if the major part of Cd is bound to MT.The technique of perturbed angular correlation spectroscopy (PAC) has been applied to living Cd-resistant cells.It was shown that > 66% of Cd in the resistant strains was bound to MT, and that MT is apparently freely suspended in the cell cytoplasm.Chelating agents differ in toxicity and Cd-releasing effect on the cells, but apparently remove the non-MT-bound Cd pool.After various periods of Cd omission, either in vitro or in vivo, growing the cells as tumors in athymic nude mice, the stability of Cd resistance in these cells seems to be dependent on the capacity of cells for de novo synthesis of MT shortly after re-exposure to the metal.
Tuberculosis: epidemiology
Authors: K Greveson, C Murray, C Toumpanakis, L Baptista, I Cropley, M Hamilton
Journal: Thorax (2009)

responsible for completing the process.However, little is known about how PCTs follow up and screen new entrants referred from the port of entry.Aims To investigate the processes and methods PCTs use in screening new entrants for TB, and whether this differs between low (incidence ,20/100 000) and high (incidence >20/100 000) TB burden PCTs.Methods An anonymous 20-point questionnaire was administered to all 192 PCTs in the UK asking: which new entrants are followed up, who is screened for latent TB infection (LTBI) and how they are screened for LTBI.Descriptive analyses were undertaken.Categorical responses were compared using a x 2 test with a p value ,0.05 considered significant.Results 177/192 (92.2%)PCTs responded; 76.3% were low-burden PCTs.All 177 PCTs followed up abnormal chest radiographs.However, only 107/177 (60.4%) screened new entrants for LTBI; high-burden PCTs were significantly less likely than low-burden PCTs to screen new entrants for LTBI (OR 0.26, 95% CI 0.12 to 0.54, p,0.0001).Few new entrants had active TB diagnosed (median 0.0%, IQR 0.0-0.5%),but more had LTBI (median 7.85%, IQR 3.95-14.25%).PCTs which screened for LTBI varied in the new entrant subgroups they elected to screen (depending on TB incidence in the originating country), particularly in those aged 16-35 years where low-burden PCTs were significantly more likely to follow NICE guidance on who to screen (p = 0.047).Heterogeneity also existed in the protocols by which new entrants were screened for LTBI (table 1).More low-burden PCTs than highburden PCTs used interferon-gamma release assays in diagnosing LTBI.Overall, 65.7% and 32.4% of PCTs followed NICE guidance on how to screen the ,16 and 16-35 age groups, respectively.Conclusions Considerable heterogeneity, inconsistency and lack of adherence to NICE guidance exist at all levels of the UK new entrant screening process.Current screening practices should therefore be reevaluated in the context of the clinical and health economic evidence base to develop a nationally standardised cost-effective policy. P78
Angiopoietin-2 Plasma Dosage Predicts Time to First Treatment (TTFT) and Overall Survival (OS) in Chronic Lymphocytic Leukemia.
Authors: Rossana Maffei, Silvia Martinelli, Rita Santachiara, Davide Rossi, Gian Matteo Rigolin, Stefania Fiorcari, Marcella Fontana, Valeria Coluccio, Giovanna Leonardi, Patrizia Zucchini, Antonio Cuneo, Valter Gattei, Giovanni Del Poeta, Francesco Forconi, Gianluca Gaidano, Giuseppe Torelli, Roberto Marasca
Journal: Blood (2009)
Vitamin B 12 absorption tests. Their unreliability in postgastrectomy states
Authors: K. Mahmud
Journal: JAMA (1971)

Eighty-two patients who underwent gastrectomy were investigated for vitamin B<sub>12</sub>deficiency 1 to 22 years after surgery. Serum vitamin B<sub>12</sub>levels were found to be abnormally low in 62. Red blood cell (RBC) B<sub>12</sub>levels were determined in 22 patients with decreased serum B<sub>12</sub>levels, and were found to be low in 21, demonstrating a true tissue deficiency of the vitamin. More than two thirds of the patients with subnormal serum B<sub>12</sub>levels had normal absorption by the Schilling and the plasma B<sub>12</sub>absorption methods. It is reasoned that most such patients have difficulty in absorbing the protein-bound food B<sub>12</sub>and not the crystalline B<sub>12</sub>used in various B<sub>12</sub>absorption tests. The latter therefore seem to have very little value in the follow-up of partial gastrectomy. Serum or RBC B<sub>12</sub>determinations are suggested for this purpose, instead.
The 12th Report of the Human Renal Transplant Registry
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: K Teahon
Journal: Gut (1994)

The transient receptor potential ankyrin-1 (TRPA1) channel has emerged as an attractive target for development of analgesic and anti-inflammatory drugs. However, drug discovery efforts targeting TRPA1 have been hampered by differences between human and rodent species. Many compounds have been identified to have antagonist activity at human TRPA1 (hTRPA1), but when tested at rat TRPA1 (rTRPA1) and mouse TRPA1 (mTRPA1), they show reduced potency as antagonists, no effect, or agonist activity. These compounds are excluded from further drug development because they cannot be tested in preclinical studies using conventional rat/mouse models. To broaden our understanding of species-specific differences, we cloned and functionally characterized rhesus monkey TRPA1 (rhTRPA1) and compared its pharmacological profile to hTRPA1, rTRPA1, and mTRPA1 channels. The functional activities of a diverse group of TRPA1 ligands (both reactive and nonreactive) were determined in a fluorescent Ca<sup>2+</sup> influx assay, using transiently transfected human embryonic kidney 293-F cells. 4-Methyl-<i>N</i>-[2,2,2-trichloro-1-(4-nitro-phenylsulfanyl)-ethyl]-benzamide, menthol, and caffeine displayed species-specific differential pharmacology at TRPA1. The pharmacological profile of the rhTRPA1 channel was found to be similar to the hTRPA1 channel. In contrast, the rTRPA1 and mTRPA1 channels closely resembled each other but were pharmacologically distinct from either hTRPA1 or rhTRPA1 channels. Our findings reveal that TRPA1 function differs between primate and rodent species and suggest that rhesus monkey could serve as a surrogate species for humans in preclinical studies.
Swedes insured against adverse drug effects
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BASES FOR EXPERT OPINIONS.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Shared risk factors for falls, incontinence, and functional dependence. Unifying the approach to geriatric syndromes
Authors: M. E. Tinetti
Journal: JAMA (1995)

<h3>Objective.</h3> —To determine whether a set of factors representing impairments in multiple areas could be identified that predisposes to falling, incontinence, and functional dependence. <h3>Design.</h3> —Population-based cohort with a 1-year follow-up. <h3>Setting.</h3> —General community. <h3>Participants.</h3> —A total of 927 New Haven, Conn, residents, aged 72 years and older who completed the baseline and 1-year interviews. <h3>Main Outcome Measures.</h3> —At least one episode of urinary incontinence per week, at least two falls during the follow-up year, and dependence on human help for one or more basic activities of daily living. <h3>Results.</h3> —At 1 year, urinary incontinence was reported by 16%, at least two falls by 10%, and functional dependence by 20% of participants. The four independent predisposing factors for the outcomes of incontinence, falling, and functional dependence included slow timed chair stands (lower extremity impairment), decreased arm strength (upper extremity impairment), decreased vision and hearing (sensory impairment), and either a high anxiety or depression score (affective impairment). There was a significant increase in each of incontinence, falling, and functional dependence as the number of these predisposing factors increased. For example, the proportion of participants experiencing functional dependence doubled (7% to 14% to 28% to 60%) (X<sup>2</sup>=119.8;<i>P</i>&lt;.001) as the number of predisposing factors increased from zero to one to two to at least three. <h3>Conclusions.</h3> —Our findings suggest that predisposition to geriatric syndromes and functional dependence may result when impairments in multiple domains compromise compensatory ability. It may be possible to restore compensatory ability and prevent or delay the onset of several geriatric syndromes and, perhaps, functional dependence by modifying a shared set of predisposing factors. Perhaps it is time to take a more unified approach to the geriatric syndromes and functional dependence. (<i>JAMA</i>. 1995;273:1348-1353)