tbuckley/cabot-search huggingface dataset:
Deadly Sudan virus reemerges in Uganda after 10 years – a potential public health threat in the COVID-19 era: a situational analysis
Authors: Ranjan K. Mohapatra, Lakshmi Venkata Simhachalam Kutikuppala, Venkataramana Kandi, Ashish K. Sarangi, Rudra N. Sahoo, Snehasish Mishra
Journal: International Journal of Surgery (2023)

Mohapatra, Ranjan K. MSc, MPhil, PhD; Kutikuppala, Lakshmi Venkata Simhachalam MBBS; Kandi, Venkataramana PhD; Sarangi, Ashish K. PhD; Sahoo, Rudra N. PhD; Mishra, Snehasish PhD Author Information
Association of severity in the grading of microvascular invasion with long-term oncological prognosis after liver resection for early-stage hepatocellular carcinoma: a multicenter retrospective cohort study from a hepatitis B virus-endemic area
Authors: Xin-Fei Xu, Yong-Kang Diao, Yong-Yi Zeng, Chao Li, Feng-Wei Li, Li-Yang Sun, Han Wu, Kong-Ying Lin, Lan-Qing Yao, Ming-Da Wang, Cheng-Wu Zhang, Wan Yee Lau, Feng Shen, Tian Yang
Journal: International Journal of Surgery (2023)

The presence of microvascular invasion (MVI) is a significant malignant pathological feature related to recurrence and survival after liver resection for hepatocellular carcinoma (HCC). This study aimed to investigate the relationship between the severity in the grading of MVI and long-term oncological outcomes in patients with early-stage HCC.A retrospective study was conducted on a prospectively maintained multicenter database on patients who underwent curative resection for Barcelona Clinic Liver Cancer stage 0/A HCC between 2017 and 2020. Patients were classified into three groups according to the severity in the grading of MVI: M0 (no MVI), M1 (1-5 sites of MVI occurring ≤1 cm away from the tumor), and M2 (>5 sites occurring ≤1 cm and/or any site occurring >1 cm away from the tumor). Recurrence-free survival (RFS) and overall survival (OS) were compared among the groups.Of 388 patients, M0, M1, and M2 of the MVI gradings were present in 223 (57.5%), 118 (30.4%), and 47 (12.1%) patients, respectively. The median OS and RFS in patients with M0, M1, and M2 were 61.1, 52.7, and 27.4 months; and 43.0, 29.1, and 13.1 months (both P <0.001), respectively. Multivariable analyses identified both M1 and M2 to be independent risk factors for OS [hazard ratio (HR): 1.682, P =0.003; and HR: 3.570, P <0.001] and RFS (HR: 1.550, P =0.037; and HR: 2.256, P <0.001).The severity in the grading of MVI was independently associated with recurrence and survival after HCC resection. Patients with the presence of MVI, especially those with a more severe MVI grading (M2), require more stringent recurrence surveillance and/or active adjuvant therapy against recurrence.
Co-authorship group significantly impacts reported arterial blood pressure variations in rodents exposed to intermittent hypoxia: a meta-research study
Authors: Charles Khouri, Bayan El Amine, Claire Arnaud, Elise Belaidi, Quentin Boete, Diane Godin-Ribuot, Patrick Levy, Gilles Faury, Olfa Harki, Jean-Luc Cracowski, Anne Briançon-Marjollet, Jean-Louis Pepin
Journal: Cardiovascular Research (2023)
Spleen-selective co-delivery of mRNA and TLR4 agonist-loaded LNPs for synergistic immunostimulation and Th1 immune responses
Authors: Longze Pan, Lijing Zhang, Wenjing Deng, Jia Lou, Xiaoke Gao, Xiaohan Lou, Yangyang Liu, Xiaohan Yao, Yuqiao Sheng, Yan Yan, Chen Ni, Ming Wang, Chuntao Tian, Fazhan Wang, Zhihai Qin
Journal: Journal of Controlled Release (2023)
The Isolated Humeral Metastasis as the Initial Presentation of Renal Cell Carcinoma Revealed by 18F-FDG PET/CT
Authors: Guozhu Hou, Wenjie Zhang, Rong Zheng
Journal: Clinical Nuclear Medicine (2023)

Abstract Renal cell carcinoma (RCC) with isolated humeral metastasis as the initial presentation is rare. We reported FDG PET/CT findings of isolated humeral metastasis from RCC in a 63-year-old man with right upper arm pain as the initial presentation. The bone scanning in an outside hospital showed that the focus with increased uptake of the right humerus was possibly malignant. FDG PET/CT showed that the right humeral mass had intense activity, and there was an additional FDG lesion in the lower pole of the right kidney. The mass of the right humerus was later confirmed as humeral metastasis from RCC by pathological examination.
An open call for nano-based therapy to address COVID-19 and oncological clinical conditions
Authors: Rasmita Dash, Rudra N. Sahoo, Gurudutta Pattnaik, Ashish K. Sarangi, Venkataramana Kandi, Snehasish Mishra, Sarika Verma, Ranjan K. Mohapatra
Journal: International Journal of Surgery (2023)

Dash, Rasmita M.Pharm; Sahoo, Rudra N. PhD; Pattnaik, Gurudutta PhD; Sarangi, Ashish K. PhD; Kandi, Venkataramana PhD; Mishra, Snehasish PhD; Verma, Sarika PhD; Mohapatra, Ranjan K. PhD Author Information
Co-Clinical Study of [fam-] Trastuzumab Deruxtecan (DS8201a) in Patient-Derived Xenograft Models of Uterine Carcinosarcoma and Its Association with Clinical Efficacy
Authors: Shigehiro Yagishita, Tadaaki Nishikawa, Hiroshi Yoshida, Daisuke Shintani, Sho Sato, Maiko Miwa, Mikiko Suzuki, Masanori Yasuda, Yusuke Ogitani, Takahiro Jikoh, Kan Yonemori, Kosei Hasegawa, Akinobu Hamada
Journal: Clinical Cancer Research (2023)

Abstract Purpose: Uterine carcinosarcoma (UCS), a subtype of endometrial carcinoma, is a rare and aggressive cancer with a poor prognosis. High clinical efficacy of trastuzumab deruxtecan (T-DXd) in HER2-expressing UCS was recently reported in a phase II trial (STATICE trial). We performed a co-clinical study of T-DXd using patient-derived xenograft (PDX) models of participants in the STATICE trial. Experimental Design: Tumor specimens were resected during primary surgery or biopsied at recurrence from patients with UCS and transplanted into immunodeficient mice. Seven UCS-PDXs from six patients were established and HER2, estrogen receptor (ER), and p53 expression in PDX and the original tumor was assessed. Drug efficacy tests were performed using six of the seven PDXs. Of the six UCS-PDXs tested, two were derived from patients enrolled in the STATICE trial. Results: The histopathological characteristics of the six PDXs were well-conserved from the original tumors. HER2 expression was 1+ in all PDXs, and ER and p53 expression was almost similar to that in the original tumors. Remarkable tumor shrinkage after T-DXd administration was observed in four of the six PDXs (67%), comparable with the response rate (70%) of HER2 1+ patients in the STATICE trial. Two patients enrolled in the STATICE trial showed partial response as the best response, and the clinical effect was well-replicated with marked tumor shrinkage. Conclusions: We successfully performed a co-clinical study of T-DXd in HER2-expressing UCS, along with the STATICE trial. Our PDX models can predict clinical efficacy and serve as an effective preclinical evaluation platform.
Signaling Pathways of the Insulin-like Growth Factor Binding Proteins
Authors: Robert C Baxter
Journal: Endocrine Reviews (2023)

The 6 high-affinity insulin-like growth factor binding proteins (IGFBPs) are multifunctional proteins that modulate cell signaling through multiple pathways. Their canonical function at the cellular level is to impede access of insulin-like growth factor (IGF)-1 and IGF-2 to their principal receptor IGF1R, but IGFBPs can also inhibit, or sometimes enhance, IGF1R signaling either through their own post-translational modifications, such as phosphorylation or limited proteolysis, or by their interactions with other regulatory proteins. Beyond the regulation of IGF1R activity, IGFBPs have been shown to modulate cell survival, migration, metabolism, and other functions through mechanisms that do not appear to involve the IGF-IGF1R system. This is achieved by interacting directly or functionally with integrins, transforming growth factor β family receptors, and other cell-surface proteins as well as intracellular ligands that are intermediates in a wide range of pathways. Within the nucleus, IGFBPs can regulate the diverse range of functions of class II nuclear hormone receptors and have roles in both cell senescence and DNA damage repair by the nonhomologous end-joining pathway, thus potentially modifying the efficacy of certain cancer therapeutics. They also modulate some immune functions and may have a role in autoimmune conditions such as rheumatoid arthritis. IGFBPs have been proposed as attractive therapeutic targets, but their ubiquity in the circulation and at the cellular level raises many challenges. By understanding the diversity of regulatory pathways with which IGFBPs interact, there may still be therapeutic opportunities based on modulation of IGFBP-dependent signaling.
Efficacy of smallpox approved tecovirimat (Tpoxx) drug against Monkeypox: current update and futuristic prospects
Authors: Tuyelee Das, Samapika Nandy, Arabinda Ghosh, Deepak Chandran, Anil K. Sharma, Kuldeep Dhama, Abhijit Dey
Journal: International Journal of Surgery (2023)

Das, Tuyelee Msc; Nandy, Samapika Msc; Ghosh, Arabinda PhD; Chandran, Deepak PhD; Sharma, Anil K. PhD; Dhama, Kuldeep PhD; Dey, Abhijit PhD Author Information
The role of cytoreductive nephrectomy in metastatic renal cell carcinoma in the targeted therapy and immunological therapy era: a systematic review and meta-analysis
Authors: Bo Chen, Jinze Li, Yin Huang, Bo Tang, Jinjiang Jiang, Zeyu Chen, Jin Li, Puze Wang, Dehong Cao, Liangren Liu, Qiang Wei
Journal: International Journal of Surgery (2023)

Background: The role of cytoreductive nephrectomy (CN) in metastatic renal cell carcinoma (mRCC) remains controversial. In addition, several unanswered questions regarding the use of CN remain: Can CN provide survival benefits for patients with mRCC? Where do we place CN in the treatment sequence paradigm among patients with mRCC? How do we best stratify patients with mRCC for CN therapy? Materials and Methods: A search strategy was conducted in the PubMed, Embase, and Web of Science databases. Studies were included only in the English language. The risk of bias assessment was made by using ROBINS-I (Risk of Bias in Nonrandomized Studies of Interventions) and RoB 2 (Risk of Bias 2) tools. The expected outcomes were analyzed by meta-analyses with the fixed-effects model or random effects model, including overall survival (OS) and progression-free survival (PFS). The measure of effect was the hazard ratio (HR) with a 95% CI, and sensitivity analysis was conducted to assess the reliability of the final results. Results: A total of 30 studies were included in the qualitative analysis. The HR for OS was 0.55 (95% CI, 0.50–0.61), and PFS was 0.72 (95% CI, 0.66–0.80), favoring CN compared with no CN. The upfront CN plus targeted therapy (TT) group had superior OS (HR, 0.57; 95% CI, 0.51–0.64) compared with the TT alone group. Furthermore, upfront CN plus systemic therapy (ST) was associated with numerically inferior OS compared with ST plus deferred CN in patients with mRCC (HR, 1.31; 95% CI, 0.98–1.74). Finally, the leave-one-out test of sensitivity analysis indicated that the results of this meta-analysis were stable and reliable in the overall HR estimates for these survival outcomes. Conclusions: First, CN was associated with better survival than no CN in patients with mRCC. Second, the combination of upfront CN and TT may lead to superior survival outcomes compared to TT alone in patients with mRCC. Survival outcomes were similar between the upfront CN+ST group and the ST+deferred CN group in patients with mRCC. Exact patient selection based on baseline prognostic factors is needed to promise maximal survival for patients with mRCC.
Electrical Stimulation Promotes the Vascularization and Functionalization of an Engineered Biomimetic Human Cardiac Tissue
Authors: Bingchuan Lu, Min Ye, Jingjing Xia, Zhenrui Zhang, Zhuo Xiong, Ting Zhang
Journal: Advanced Healthcare Materials (2023)

The formation of multiscale vascular networks is essential for the in vitro construction of large-scale biomimetic cardiac tissues/organs. Although a variety of bioprinting processes have been developed to achieve the construction of mesoscale and large-scale blood vessels, the formation of microvascular networks still mainly depends on the self-assembly behavior of endothelial cells (ECs), which is inefficient and demanding without appropriate stimulus. To address this problem, the elongation and connection of endothelial cells in engineered cardiac tissue (ECT) are sought to promote by electrical stimulation (ES) to achieve vascularization. As proof of the concept, bio-inks are composed of GelMA/fibrin hydrogel, human pluripotent stem cells induced cardiomyocytes (iPSC-CM), and human umbilical vein endothelial cells (HUVEC) are used for the bioprinting of ECTs. It is demonstrated that electrical stimulation significantly promotes the elongation, migration, and interconnection of HUVECs in ECT and increases the expression of related genes. Moreover, ES also enhances the secretion of signal factors interacting between CMs and HUVECs. It seems that the HUVECs further strengthen the contractility of cardiac tissue. Taken together, electrical stimulation promotes vascularization and CMs functionalization in ECT, which has important application potential in the fabrication of vascularized ECT and its clinical transplantation.
Rectus sheath block versus local anesthetic infiltration in pediatric laparoscopic inguinal hernia repair: a randomized controlled trial
Authors: Liang Chen, Shuangmei Liu, Yanyan Cao, Lei Yan, Yang Shen
Journal: International Journal of Surgery (2023)

Rectus sheath block (RSB) and local anesthetic infiltration (LAI) are used for postoperative analgesia in pediatric laparoscopic inguinal hernia repair. However, whether the analgesic effect of RSB is superior to LAI remains unclear. The authors hypothesized that RSB would reduce opioid consumption in patients.Patients aged 3-14 years scheduled for laparoscopic inguinal hernia repair were randomly allocated to the RSB, local anesthetic infiltration high concentration (LAIHC), local anesthetic infiltration low concentration (LAILC), or control groups. Preoperatively, they received 0.4 ml/kg of 0.25% ropivacaine (RSB), 0.4 ml/kg of 0.25% ropivacaine (LAILC), or 0.2 ml/kg of 0.5% ropivacaine(LAIHC), and 0.2 ml/kg of normal saline (control). The primary outcome was equivalent morphine consumption.The authors analyzed 136 patients (RSB, 33; LAIHC, 34; LAILC, 35; control, 34). Intraoperative morphine equivalent consumption was lower in the RSB group [0.115 (0.107-0.123)] than in the LAIHC [0.144 (0.137-0.151)], LAILC [0.141 (0.134-0.149)], and control [0.160 (0.151-0.170)] groups ( P <0.001). In the post-anesthesia care unit, morphine equivalent consumption differed between the RSB [0.018 (0.010-0.027)], LAIHC [0.038 (0.028-0.049)], LAILC [0.056 (0.044-0.067)], and control [0.074 (0.063-0.084)] groups ( P <0.001). The rescue morphine equivalent consumption did not differ significantly between the RSB [0.015 (0.007-0.023)] and LAIHC [0.019 (0.010-0.029)] groups, which were lower than that in the control group [0.037 (0.029-0.045)] ( P =0.001).RSB can provide effective analgesia for pediatric laparoscopic inguinal hernia repair, with better effectiveness than that of LAI at the same dose.
A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy
Authors: Amr El Zawily, Frederick S. Vizeacoumar, Renuka Dahiya, Sara L. Banerjee, Kalpana K. Bhanumathy, Hussain Elhasasna, Glinton Hanover, Jessica C. Sharpe, Malkon G. Sanchez, Paul Greidanus, R. Greg Stacey, Kyung-Mee Moon, Ilya Alexandrov, Juha P. Himanen, Dimitar B. Nikolov, Humphrey Fonge, Aaron P. White, Leonard J. Foster, Bingcheng Wang, Behzad M. Toosi, Nicolas Bisson, Tajib A. Mirzabekov, Franco J. Vizeacoumar, Andrew Freywald
Journal: Clinical Cancer Research (2023)

Accumulating analyses of pro-oncogenic molecular mechanisms triggered a rapid development of targeted cancer therapies. Although many of these treatments produce impressive initial responses, eventual resistance onset is practically unavoidable. One of the main approaches for preventing this refractory condition relies on the implementation of combination therapies. This includes dual-specificity reagents that affect both of their targets with a high level of selectivity. Unfortunately, selection of target combinations for these treatments is often confounded by limitations in our understanding of tumor biology. Here, we describe and validate a multipronged unbiased strategy for predicting optimal co-targets for bispecific therapeutics.
Syrian women’s mental health
Authors: Sarya Swed, Mohammed A. Rais, Ahmed Aljabali, Abdelmonem Siddiq, Amro A. El-Sakka, Muhammad M. Patwary, Mohamed Elsayed, Sheikh Shoib
Journal: International Journal of Surgery (2023)

Swed, Sarya MDa; Rais, Mohammed A. MDb; Aljabali, Ahmed MDc,; Siddiq, Abdelmonem MDd; El-Sakka, Amro A. MDe; Patwary, Muhammad M. MDf,g; Elsayed, Mohamed MDh; Shoib, Sheikh MDi Author Information
A LASSO-derived prediction model for assessing the risk of lymph node metastasis in T1 and T2 epithelial ovarian cancer: an international retrospective cohort study
Authors: Jieyu Wang, Shouzhen Chen, Fangfang Zhong, Tingting Zhu, Yuqing Zhao
Journal: International Journal of Surgery (2023)

The necessity of lymphadenectomy remains controversial in patients with early ovarian cancer. This study aimed to estimate the prevalence of lymph node metastasis (LNM) in patients with apparent local epithelial ovarian cancer (EOC) and to develop a risk model for the prediction of LNM in local EOC with machine learning algorithms.A cohort of 4110 patients who underwent lymphadenectomy with apparent local EOC were retrospectively evaluated. In the model development, a least absolute shrinkage and selection operator (LASSO)-derived Cox regression with internal 10-fold cross-validation was used to identify the risk factors of LNM. Clinical performance was assessed using the decision curve analysis, and a nomogram-based analysis was used to identify the risk factors for LNM.The incidence rate of LNM was rare in our cohort, at 7.4% (213/2885) in the primary set and 4.8% (59/1225) in the validation set. After feature selection, 10-fold internal validation, and external validation, our risk model performed well in both the discrimination (area under the curve=0.790 in the primary set and area under the curve=0.752 in the validation set) and the Hosmer-Lemeshow tests (P=0.873 in the primary set and P=0.380 in the validation set). Additionally, decision curve analysis demonstrated the superiority of our model for clinical interventions in daily practice.LNM is rare in patients with local EOC. In our study, which is based on machine learning algorithms, we developed a prediction model to identify patients with local EOC who could benefit from lymphadenectomy.
Patterns and prognostic values of programmed cell death-ligand 1 expression and CD8+ T-cell infiltration in small cell carcinoma of the esophagus: a retrospective analysis of 34 years of National Cancer Center data in China
Authors: Chaoqi Zhang, Guochao Zhang, Liyan Xue, Zhihui Zhang, Qingpeng Zeng, Peng Wu, Lide Wang, Zhaoyang Yang, Bo Zheng, Fengwei Tan, Qi Xue, Shugeng Gao, Nan Sun, Jie He
Journal: International Journal of Surgery (2023)

Background: Small cell carcinoma of the esophagus (SCCE) is an extremely rare and highly aggressive neuroendocrine malignancy with a strikingly poor prognosis. Given the great clinical successes of checkpoint immunotherapies, we explored the expression profile and clinical significance of programmed cell death-ligand 1 (PD-L1) and CD8 + T cell in SCCE for the first time. Materials and methods: Tumor-infiltrating immune cells (TIICs) and tumor cells in postoperative, whole tumor sections from 147 SCCE patients were stained for PD-LI expression. We also evaluated each patient’s Combined Positive Score (CPS). Multiplex immunofluorescence staining (CD3, CD20, CD68, and PD-L1) was introduced to clarify the location of PD-L1. CD8 density was analyzed by digital imaging and analysis of entire slides. Clinical outcomes were tested for correlations with both PD-L1 expression and CD8 density. Results: No patients had PD-L1 expressed in their tumor cells. PD-L1 + expression in TIICs was detected in 65 patients (44.2%) and 42 (28.6%) exhibited CPS positivity. Multiplex immunofluorescence staining demonstrated that most of the PD-L1 was expressed on the CD68 + monocytes/macrophages. PD-L1 expression in the TIICs and CPS was found to be correlated with paraffin block age, tumor length, macroscopic type, T stage, and increased overall survival (OS). Expression of PD-L1 in TIICs showed significantly prolonged relapse-free survival (RFS). Increasing CD8 densities were associated with increased PD-L1 expression ( P trend &lt;0.0001). Multivariate regression confirmed that PD-L1 in TIICs and CD8 states were independent predictors of OS, and CD8 status were found to be independently predictive of RFS. A stratification based on PD-L1 and CD8 status was also significantly associated with both OS and RFS. Conclusion: Expression of PD-L1 was only detected in TIICs from approximately half of the patients with SCCEs. In SCCEs, PD-L1 and CD8 status are novel prognostic biomarkers and may inform the implementation of risk-related therapeutic strategies. SCCEs with higher CD8 infiltration also had higher expression of PD-L1, suggesting the development of resistance against adaptive immunity. These findings support the assertion that PD-L1/programmed cell death 1 inhibitors should be investigated in this rare malignancy.
Breaking Up Isn't Hard to Do: Isolating Cell-free DNA Fragments in Osteosarcoma
Authors: Daniel A. Weiser, Masanori Hayashi, Mark A. Applebaum
Journal: Clinical Cancer Research (2023)

Summary The novel use of blood-based biospecimens from a retrospective cohort of 50 patients with osteosarcoma was recently studied. The potential clinical utility of sorting cell-free DNA by fragment size was defined, with shorter tumor-specific DNA enrichment providing prognostic value and allowing for streamlined molecular profiling of circulating tumor material. See related article by Udomruk et al., p. 2085
Hemolytic anemia and macrothrombocytopenia: A lipid problem?
Authors: Mary Risinger, Phyllis S. Kim, Roberto X. Rodriguez, Monica Narvaez Rivas, Kenneth D. R. Setchell, Wenying Zhang, Theodosia A. Kalfa
Journal: American Journal of Hematology (2023)

Kenneth D. R. Setchell discloses equity in Asklepion Pharmaceuticala and is a consultant to Travere Therapeutics and Mirum Pharmaceuticals. The other authors have no competing financial interests. The data from this study (anonymized results) are available from the corresponding author upon request. Figure S1. Blood smear, complete blood count with red blood cell indices, platelet count and mean platelet volume, and histograms depicting the RBC hemoglobin concentration and cell volume evaluated in an Advia instrument from the patient before (upper panel) and >8 months after treatment with reduced plant sterol and cholesterol diet and ezetimibe (lower panel). Although occasional stomatocytes were observed in the post-treatment blood smear, they were significantly reduced in number compared to the pre-treatment sample. Post-treatment MCV was decreased and the absolute reticulocyte count was normalized. The platelet count increased and the mean platelet volume decreased, although not to normal values. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.