tbuckley/cabot-search huggingface dataset:
Anatomy Lesson
Authors: B Cucchiara
Journal: Annals of Internal Medicine (2000)

Ad Libitum5 December 2000Anatomy LessonBrett Cucchiara, MDBrett Cucchiara, MDPhiladelphia, PA 19104 (Cucchiara)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-11-200012050-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This nameless body, this discarded skin,This box of bones, this broken block of clay,These few remains of a long lifetime's end; You once were young—but youth soon fades away,You once were old—not even age can stay.Upon this very stone you may have treadOne day long ago, hand in hand with lifeAs I do now; Upon this very bed,You may yet lie in dream's disturbing strife,As I present you with my nervous knife.No lofty view from rare ... Author, Article, and Disclosure InformationAffiliations: Philadelphia, PA 19104 (Cucchiara)Corresponding Author: Brett Cucchiara, MD, Department of Neurology, University of Pennsylvania Medical Center, 3 West Gates Building, 3400 West Spruce Street, Philadelphia, PA 19104. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 December 2000Volume 133, Issue 11Page: 914KeywordsAdolescentsBone fractureDustFatsNeurologySmellTouch ePublished: 5 December 2000 Issue Published: 5 December 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Importance of the Dosing Procedure in the Radiotriolein Test for Steatorrhea
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reduction of bacteriuria and pyuria using cranberry juice
Authors: L. M. Katz
Journal: JAMA (1994)

<h3>To the Editor.</h3> —While it is attractive in these high-tech times to embrace low-tech approaches to disease prevention and control, Dr Avorn and colleagues<sup>1</sup>have not made their case for cranberry juice. From data in Table 1 of the article (page 753), it is apparent that their randomization and/or blinding scheme failed and that the two groups were not comparable with regard to previous UTI (Table). Analysis of the history of UTI for the prior 6-month and 12-month periods demonstrates a significant excess in the placebo group during both periods (<i>P</i>=.004, odds ratio [OR]=4.39, 95% confidence interval 1.55 to 12.43, using the approximation of Woolf, and<i>P</i>=.03, OR=2.50, 95% confidence interval 1.15 to 5.42, using the approximation of Woolf, respectively [Fisher's exact test]), suggesting the placebo group was more likely at baseline to experience UTI or bacteriuria/pyuria than the treatment group.
Erratum: Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis
Authors: George F Mells, James A B Floyd, Katherine I Morley, Heather J Cordell, Christopher S Franklin, So-Youn Shin, Michael A Heneghan, James M Neuberger, Peter T Donaldson, Darren B Day, Samantha J Ducker, Agnes W Muriithi, Elizabeth F Wheater, Christopher J Hammond, Muhammad F Dawwas, David E Jones, Leena Peltonen, Graeme J Alexander, Richard N Sandford, Carl A Anderson
Journal: Nature Genetics (2011)
Acellular and whole-cell pertussis vaccines in Japan. Report of a visit by US scientists
Authors: G. R. Noble
Journal: JAMA (1987)

Since the introduction of acellular pertussis vaccines in Japan late in 1981, more than 20 million doses have been administered, mostly to children 2 years of age and older. Clinical studies indicate that mild local and febrile reactions are less frequent after administration of acellular pertussis vaccines than after whole-cell vaccines. Serious adverse events with sequelae occurred in 2-year-old children at approximately the same low rate during the period 1975 through August 1981, when whole-cell vaccines were used, and during August 1981 through 1984, when acellular vaccines were used exclusively. Five household contact studies have yielded vaccine efficacy estimates ranging from 78% to 92% in children 1 year of age or older. In addition, there has been a continuing decrease in reported pertussis incidence from the epidemic peak in 1979. Additional data on the safety and efficacy of acellular pertussis vaccines administered to infants would be useful in consideration of acellular pertussis vaccine licensure in the United States. (<i>JAMA</i>1987;257:1351-1356)
TREATMENT OF INOPERABLE MALIGNANT DISEASE.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CREATIN AND MUSCLE TONUS IN MAN
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Carcinogenesis across the placenta.
Journal: BMJ (1973)

lapsed cusp) of the circumflex coronary artery in the atrioventricular groove needs confirmation.A "contraction ring" dividing the left ventricle into two halves, a pressure gradient between the two, and a disturbance of contractility in the posteroinferior wall have been described,20 tbut they also fail to convince as an explanation of the E.C.G. unless ectopic beats, hypertrophic cardiomyopathy, over-empty- ing of the left ventricle in mitral regurgitation, and pressure artefacts due to trapping of the catheter tip have all been excluded.And so the syndrome still clings to some of its secrets.
Eradicating Legionella from hospital water
Authors: J. E. Stout
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The report by the Centers for Disease Control and Prevention (CDC) on transmission of nosocomial legionnaires disease<sup>1</sup>documents failure to eradicate<i>Legionella</i>organisms from the water distribution systems of 2 hospitals despite the use of hyperchlorination, thermal disinfection, and/ or metal ionization. The efficacy of these decontamination methods can be compromised by a variety of factors. The duration of thermal decontamination (160°F/71°C at the tap) used in hospital Y was only 5 minutes. The original report on the use of this method specified a 30-minute flush at the tap.<sup>2</sup>Thus, failure to maintain the elevated temperature for a sufficient period undoubtedly contributed to this failure to eradicate<i>Legionella</i>. In fact, when one California hospital applied thermal eradication with a flush time of 5 minutes, as recommended by the CDC, distal site colonization by<i>Legionella</i>organisms was unaffected. When the process was repeated using a 30-minute flush
Professor Huxley
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Researchers look forward to sea granting gifts
Authors: M. F. Goldsmith
Journal: JAMA (1996)

"ALL THAT WE DO," wrote Richard Wilbur, "is touched with ocean, yet we remain on the shore of what we know." Scientists searching the sea for new drugs to treat human diseases seem to take the poet's words as a given and a challenge. More than 120 drugs developed from the traditional source, soil microorganisms, are used today to treat infectious diseases, cancer, and other ills. But a dramatic decline in discoveries based on soil microorganisms—more than 95% of new "drug leads" derived from them today turn out to be already known antibiotics—and increasing resistance to existing drugs, has led enterprising investigators to search the waters of the earth for medically useful microbes. "Marine microorganisms are, by comparison [with soil organisms], poorly known biologically," observes William Fenical, PhD, professor of oceanography at Scripps Institution of Oceanography's Center for Marine Biotechnology and Medicine at the University of California, San Diego, in
VITAMIN SUPPLEMENTATION AND NEURAL TUBE DEFECTS
Authors: E.G. Knox, Irvin Emanuel, R.W. Smithells, M.J. Seller, R. Harris, D.W. Fielding, C.J. Schorah, N.C. Nevin, S. Sheppard, A.P. Read, S. Walker, J. Wild, Monica Holmes-Siedle
Journal: The Lancet (1983)
Effect of Copper and Zinc Status on Susceptibility to Cadmium Intoxication
Authors: I. Bremner, J. K. Campbell
Journal: Environmental Health Perspectives (1978)

The effects of dietary cadmium on copper and zinc metabolism in animals are described. Emphasis is given to situations involving chronic exposure to low levels of cadmium, to the identification of population groups most at risk, and to the protective effect of dietary supplementation with copper and zinc. The mechanism of the interaction between the metals and the involvement of metallothionein are discussed.
Erectile Dysfunction
Authors: Ridwan Shabsigh, Aristotelis G. Anastasiadis
Journal: Annual Review of Medicine (2003)

Erectile dysfunction (ED) is a highly prevalent and often undertreated condition. It may be a symptom of underlying, chronic illness and can have a negative impact on quality of life, psychosocial health, and relationships. The aging of the population, as well as the introduction of new treatment options, such as sildenafil, has led to increased public awareness of this disorder. New oral therapeutic agents are on the horizon. This article provides an overview of the physiology of erection, the pathophysiology of ED, and modern patient evaluation. Management options, including traditional therapeutic approaches as well as the new generation of oral agents, are also presented.
Management of breast cancer: radical mastectomy. In rebuttal to Dr. Crile
Authors: T. J. Anglem
Journal: JAMA (1974)

THE rejection of Dr. Crile's policies by most informed surgeons is not a consequence of uncertainty as to his precise meaning about local excision or "partial mastectomy." It is rather a consequence of wide recognition of the extensive and easily demonstrable bias introduced by favorable case selection for the simple procedures that characterize his reports. This has been amply demonstrated in our article. There are, however, some points in Crile's article that merit further discussion and rebuttal. Crile asks, "Is there increased risk in partial mastectomy?" He answers the question by citing a retrospective, randomized, matched-pair study that as originally reported consisted of two groups of 53 patients: one group was treated by partial mastectomy and the other by total mastectomy. The ten-year survival rate for the partial mastectomy patients was a meager 34.4%. The data for the total mastectomy patients are not given, but it is stated that
Abbreviations
Authors: Malcolm R. Lewis
Journal: JAMA (1976)

<h3>To the Editor.—</h3> Initials used to designate terms in clinical medicine are convenient, but often confusing, to wit: a certain patient after a parietal cell vagotomy done for a duodenal ulcer, had a drop in blood pressure with a normal packed cell volume. His central venous pressure was normal, but the situation was soon complicated by a run of ventricular premature contractions. The question arose that, with a normal PCV and CVP after a PCV, why the VPCs?
Special Article
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase I study of LY573636-sodium, an acylsulfonamide anti-cancer compound with a novel mechanism of action, administered as 24-hour continuous infusion in patients with advanced solid tumors
Authors: C. A. Slapak, P. M. LoRusso, D. Mendelson, A. K. Sykes, D. P. De Alwis, M. M. Wagner, R. L. Ilaria, M. S. Gordon
Journal: Journal of Clinical Oncology (2007)

2542 Background: LY573636 -sodium (hereafter referred to as LY573636 ) is a novel anti-cancer compound that induces apoptosis by a mitochondrial-mediated mechanism. Methods: A phase I study was conducted to determine the maximum tolerated dose and pharmacokinetic (PK) profile of LY573636 administered as a 24-hour continuous intravenous (IV) infusion every 28 days. Results: 26 patients (pts) were enrolled on study, 12 males and 14 females, with a median age of 57 (range: 41–74). LY573636 was dose-escalated using a flat dosing-based schema. No dose limiting toxicity (DLT) was observed until the 2,000 mg cohort, when 1 pt developed CTCAE grade 3 hyperbilirubinemia. PK analysis revealed that LY573636 had a low total plasma clearance (CL = 0.02L/hr) and a terminal elimination half-life of approximately 340 hours due to high-albumin binding (∼99%). One additional pt in the 2,000 mg flat dose cohort developed grade 4 thrombocytopenia in cycle 2, possibly due to the accumulation of albumin-bound drug. Based on these PK and clinical data, the dosing strategy was revised to a flat loading/maintenance dose regimen of 2,500 mg/1,750 mg every 28 days by 24-hour continuous IV infusion. Thirteen pts were treated at this dose level, with 1 pt experiencing a DLT of grade 4 leukopenia. Overall, 8/26 pts had stable disease (SD) after 2 or more cycles, with 2 pts still on study. Five pts received ≥ 4 cycles (SD ≥ 4 mos), including heavily pre-treated pts with ovarian cancer, soft tissue sarcoma, and uterine cancer. Conclusions: LY573636 is a novel anti-cancer compound with a unique mechanism of action. The most common DLT was BM suppression. Because of the long half-life of LY573636 , and the encouraging findings of a separate IV bolus phase 1 study, an IV bolus-based regimen will be taken forward into phase 2 study. No significant financial relationships to disclose.
The Human Lung Mast Cell
Authors: Stephen I. Wasserman
Journal: Environmental Health Perspectives (1984)

Mast cells are present in human lung tissue, pulmonary epithelium, and free in the bronchial lumen. By virtue of their location and their possession of specific receptors for IgE and complement fragments, these cells are sentinel cells in host defense. The preformed granular mediators and newly generated lipid mediators liberated upon activation of mast cells by a variety of secretagogues supply potent vasoactive-spasmogenic mediators, chemotactic factors, active enzymes, and proteoglycans to the local environment. These factors acting together induce an immediate response manifest as edema, smooth muscle constriction, mucus production, and cough. Later these mediators and those provided from plasma and leukocytes generate a tissue infiltrate of inflammatory cells and more prolonged vasoactive-bronchospastic responses. Acute and prolonged responses may be homeostatic and provide for defense of the host, but if excessive in degree or duration may provide a chronic inflammatory substrate upon which such disorders as asthma and pulmonary fibrosis may ensue.
CORRECTION
Journal: American Journal of Psychiatry (2017)

regarding each individual's pattern of consumption that may not be true for every individual.Nevertheless, we ran a new analysis on the cohort used in the study (1).Table 1 presents the distribution of methylphenidate dispensed in the different groups according to the mean dose of methylphenidate per pill dispensed in milligrams and the immediate release, slow release, or combination thereof.There were no discernible differences between the monotherapy group and the group that also received a mood stabilizer.We agree with Dr. Ketter and Dr. Dell'Osso that more details are needed in the extent to which stimulants and antidepressants can be safely used, not only regarding dose, medication combinations, and bipolar disorder subtypes, but also regarding interindividual variation in the form of genetic or environmental factors.
Keil's Medical, Pharmaceutical and Dental Register=Directory, with special medical, pharmaceutic and dental departments containing detailed information of colleges, hospitals, asylums, societies, with street lists, etc., for Pennsylvania, New York, New Jersey, Maryland, Delaware and District of Columbia.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal