tbuckley/cabot-search huggingface dataset:
Erythrocyte fluorescence in relatives of patients with erythropoietic protoporphyria
Authors: K. D. Wuepper
Journal: JAMA (1967)

IN 1953, Kosenow and Treibs<sup>1</sup>described a new inborn error of porphyrin metabolism which Magnus et al<sup>2</sup>later termed erythropoietic protoporphyria (EPP). Porter provided evidence that EPP was due to overproduction of protoporphyrin IX in the bone marrow.<sup>3</sup>Erythrocyte and fecal protoporphyrins and, at times, coproporphyrins are increased, but urinary porphyrins are normal in affected individuals.<sup>1</sup>Erythrocytes<sup>1,4,5</sup>and their precursors<sup>6,7</sup>have been observed to fluoresce in some cases but not in others.<sup>8</sup>A dominant form of inheritance has been suggested by several authors.<sup>6,9-12</sup>Asymptomatic relatives with "latent" EPP have been previously identified by slightly increased red blood cell (RBC) protoporphyrin concentrations.<sup>6,13,14</sup>We now report increased numbers of red-fluorescing erythrocytes with<i>normal</i>RBC protoporphyrin concentrations in four asymptomatic relatives of two patients with EPP. In addition, a sibling of one of the patients was found to have elevated RBC protoporphyrin levels and
Regulation of Thyroid Cell Proliferation by TSH and Other Factors: A Critical Evaluation of in Vitro Models
Authors: T. Kimura
Journal: Endocrine Reviews (2001)

TSH via cAMP, and various growth factors, in cooperation with insulin or IGF-I stimulate cell cycle progression and proliferation in various thyrocyte culture systems, including rat thyroid cell lines (FRTL-5, WRT, PC Cl3) and primary cultures of rat, dog, sheep and human thyroid. The available data on cell signaling cascades, cell cycle kinetics, and cell cycle-regulatory proteins are thoroughly and critically reviewed in these experimental systems. In most FRTL-5 cells, TSH (cAMP) merely acts as a priming/competence factor amplifying PI3K and MAPK pathway activation and DNA synthesis elicited by insulin/IGF-I. In WRT cells, TSH and insulin/IGF-I can independently activate Ras and PI3K pathways and DNA synthesis. In dog thyroid primary cultures, TSH (cAMP) does not activate Ras and PI3K, and cAMP must be continuously elevated by TSH to directly control the progression through G1 phase. This effect is exerted, at least in part, via the cAMP-dependent activation of the required cyclin D3, itself synthesized in response to insulin/IGF-I. This and other discrepancies show that the mechanistic logics of cell cycle stimulation by cAMP profoundly diverge in these different in vitro models of the same cell. Therefore, although these different thyrocyte systems constitute interesting models of the wide diversity of possible mechanisms of cAMP-dependent proliferation in various cell types, extrapolation of in vitro mechanistic data to TSH-dependent goitrogenesis in man can only be accepted in the cases where independent validation is provided.
Carpal tunnel syndrome in patients undergoing maintenance hemodialysis
Authors: V. K. Jain
Journal: JAMA (1979)

Five of 62 maintenance hemodialysis patients were found to have carpal tunnel syndrome, and another five had prolonged distal motor latencies. Contrary to previous reports, there was no relation between carpal tunnel syndrome and the site of vascular access. Synovial biopsy specimens from flexor tendons demonstrated edema without inflammation, suggesting that extracellular fluid volume excess in the presence of flexion and immobility during dialysis may be pathogenetically important. (<i>JAMA</i>242:2868-2869, 1979)
LETTER FROM LONDON.
Authors: None G. O. M.
Journal: JAMA (1890)

(FROM OUR OWN CORRESPONDENT.) Strychnine as a Remedy in Chronic Alcoholism and Dipsomania—Volunteer Nurses for Lepers— Sir Morell Mackenzie on "The Voice"—Amenorrhœa due to Mental Shock and with Mental Depression—A Case of Raynaud's Disease. The most hopelessly addicted to alcoholic beverages would seem to have found a friend in a certain medical man, who has recently contributed an article on alcoholism, in which he describes seven cases of inebriety treated by hypodermic injections of strychnine. He states that in cases of chronic alcoholism and of dipsomania he has found strychnine a very valuable remedy. Not only are attacks cured, but the desire for drink ceases to exist. Even cases of delirium tremens yielded in a large measure to the influences of the method adopted. The treatment, however, would seem to be somewhat tedious, requiring to be carried out systematically and most frequently for long periods of time. In some exceptional
The Essential Psychoses and Their Fundamental Syndromes.
Journal: JAMA (1933)

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SAN FRANCISCO'S PLAGUE.
Journal: JAMA (1900)

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LAW &amp;amp; MEDICINE
Authors: Angela Robbey Holder
Journal: JAMA (1973)

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Biologic Evidence for the Existence of Thresholds in Chemical Carcinogenesis
Authors: Hans L. Falk
Journal: Environmental Health Perspectives (1978)

In a search for evidence for the existence of threshold levels below which chemical carcinogens do not induce cancer, it is essential to consider all aspects of the carcinogenic process.We should not confine our thoughts solely to the generally ac- cepted stages of carcinogenesis: initiation, promo- tion, and progression.Several factors may influence thresholds even before the proximate carcinogen reaches the target tissue.Important is the number of molecules that can react with the target tissue.Apart from the level of exposure, this number depends on several condi- tions.First, not all molecules with carcinogenic potential are equally well absorbed, and the degree of absorption will affect the number available.Sec- ond, not all of the molecules which enter the or- ganism reach the target tissue.For many molecules, metabolic change may produce noncarcinogenic de- rivatives, while others will be activated to the proximate carcinogen.The ultimate number of molecules in this group is dependent upon the metabolic capability of the organism to perform the necessary conversions.This may be a function of the state of enzyme induction or tissue damage.Once in the active state, a large proportion of the carcinogenic molecules may be lost to the car- cinogenic process by interaction with molecules other than DNA, that is, with any molecules that can be alkylated, such as a diversity of small molecules, with macromolecules, such as protein or RNA.While damage may result from these reac- tions, no heritable changes are produced.From the foregoing, it is evident that several pro- cesses which have no relationship to car-
Abstract 15255: Statins Augment Circulating MicroRNA-499-5p Release With Muscle Contraction and Aerobic Exercise
Authors: Pil-Ki Min, Joseph Park, Stephanie Isaacs, Beth A Taylor, Paul D Thompson, Chris Troyanos, Pierre D’Hemecourt, Sophia Dyer, Stephen Y Chan, Aaron L Baggish
Journal: Circulation (2015)

Background: Statins exacerbate exercise-induced skeletal muscle injury. Muscle-specific microRNAs (myomiRs) increase in plasma after prolonged exercise, but the patterns of myomiRs release after statin-associated muscle injury have not been examined. Objectives: We examined the relationships among statin exposure, in vitro and in vivo muscle contraction, and candidate circulating myomiRs expression. Methods: We measured plasma levels of the myomiRs, circulating microRNA-1 (c-miR-1), c-miR-133a, c-miR-206 and c-miR-499-5p, from 28 statin-using and 28 non-statin using runners before (PRE), immediately after (FINISH), and 24 hours after a 42 km footrace (POST-24). We subsequently used contracting mouse C2C12 cultured myotubes with and without statin exposure to compare intracellular and extracellular expression of these molecules. Fold-changes of microRNAs are presented as median [interquartile range]. Results: In marathoners, c-miR-1, c-miR-133a, and c-miR-206 increased at FINISH, returned to baseline at POST-24, and were unaffected by statin use. In contrast, c-miR-499-5p was unchanged at FINISH in both groups, but c-miR-499-5p increased in statin users at the POST-24 time point compared to PRE [2.9 (1.3, 8.6) vs. 1.0 fold change, p &lt;0.001] and to non-statin using runners [2.9 (1.3, 8.6) vs. 1.4 (0.9, 3.2) fold change, p &lt; 0.05]. In cultured C2C12 myotubes, intracellular levels of candidate myomiRs remained stable except for modest declines of miR-1 and miR-206 with isolated myotube contraction (carbachol exposure) or simultaneous statin and myotube contraction. Extracellular miR-1, 133a, and 206 increased with contraction regardless of statin use. In contrast, extracellular miR-499-5p was unaffected by either isolated statin exposure or isolated contraction but increased with contraction + statin [4.8 (1.9, 8.1) vs. 1.0 (0.7, 1.5) fold change, p &lt; 0.05 vs. control]. Conclusions: Statin-potentiated muscle injury during exercise is accompanied by augmented extracellular release of miR-499-5p. c-miR-499-5p may serve as a biomarker of statin-potentiated muscle damage.
Contents
Authors: Andrew Burroughs, J Vierling, S Zeuzem, F Poordad, J.-P Bronowicki, M Manns, B Bacon, R Esteban, S Flamm, P Kwo, L Pedicone, W Deng, F Dutko, M Dinubile, K Koury, F Helmond, J Wahl, S Bruno, D Byrne, C Newcomb, D Carbonari, K Nezamzadeh, M Leidl, Y.-X Herlim, S Yang, J Hennessy, M Kostman, A Leonard, V Localio, Re Lo, N Hayashi, N Izumi, H Kumada, T Okanoue, H Tsubouchi, H Yatsuhashi, M Kato, R Ki, Y Komada, C Seto, S Goto, Z Younossi, M Stepanova, G Dusheiko, C Hezode, H Reesink, O Weiland, F Nader, S Hunt, M Eslam, R Leung, M Romero-Gomez, A Mangia, W Irving, D Sheridan, U Spengler, L Mollison, W Cheng, E Bugianesi, D Mcleod, A Zaitoun, V Attino, D Goeltz, J Nattermann, M Douglas, D Booth, J George, G Ahlenstiel, P Leone, M Tacchio, S Berardi, T Santantonio, M Fasano, S Ferrone, A Vacca, F Dammacco, V Racanelli
Journal: Journal of Hepatology (2014)
Temporal Evolution of Pleural Fibrosis Induced by Intrapleural Minocycline Injection
Authors: Catherine S. H. Sassoon, Richard W. Light, Francisco S. Vargas, Steve E. Gruer, Nai-San Wang
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Minocycline is as effective as tetracycline in inducing pleural fibrosis, but the long-term pleural changes induced by minocycline are unknown. The objective of this study was to evaluate in rabbits the evolution of the pleural changes induced by the intrapleural instillation of minocycline. Under light anesthesia, minocycline at 10 mg/kg in a total volume of 2 ml of bacteriostatic saline solution was injected into the right pleural space of 25 male rabbits. The animals were sacrificed in groups of five at 15 d and 1, 2, 4, and 6 mo. Macroscopic and microscopic examinations of the pleura were performed for evidence of pleural fibrosis and inflammation. Similarly, the underlying lung was also examined for microscopic alveolar fibrosis and inflammation. During the 6-mo observation period there was no significant change in the degree of pleural fibrosis. In contrast, microscopic pleural inflammation, alveolar fibrosis, and alveolar inflammation all decreased significantly over the observation period. In conclusion, intrapleural minocycline injection results in persistent pleural fibrosis at 6 mo. It remains to be determined whether the pleural fibrosis will persist beyond this period.
Correction: The World Health Organization Fetal Growth Charts: A Multinational Longitudinal Study of Ultrasound Biometric Measurements and Estimated Fetal Weight
Authors: Torvid Kiserud, Gilda Piaggio, Guillermo Carroli, Mariana Widmer, José Carvalho, Lisa Neerup Jensen, Daniel Giordano, José Guilherme Cecatti, Hany Abdel Aleem, Sameera A. Talegawkar, Alexandra Benachi, Anke Diemert, Antoinette Tshefu Kitoto, Jadsada Thinkhamrop, Pisake Lumbiganon, Ann Tabor, Alka Kriplani, Rogelio Gonzalez, Kurt Hecher, Mark A. Hanson, A. Metin Gülmezoglu, Lawrence D. Platt
Journal: PLoS Medicine (2017)

[This corrects the article DOI: 10.1371/journal.pmed.1002220.].
Correction: Imatinib mesylate inhibits STAT5 phosphorylation in response to IL-7 and promotes T cell lymphopenia in chronic myelogenous leukemia patients
Authors: S. Thiant, M. M. Moutuou, P. Laflamme, R. Sidi Boumedine, D. M. Leboeuf, L. Busque, J. Roy, M. Guimond
Journal: Blood Cancer Journal (2020)

A correction to this paper has been published and can be accessed via a link at the top of the paper.
Stipulations
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1960)

by study of the blood of the parents), the baby about to be born is unlikely to be affected.The value of giving vitamin K to the mother before term to prevent hypoprothrombinaemia in the newborn and reduce the chance of haemorrhagic disease is still uncertain.The results of Dyggve' are in favour, but those of Sanford2 and Hay' are not.Nevertheless, some still give 5-10 mg.vitamin K orally daily for 3 or 4 weeks before term, and in the present case this might be done if only to reinforce the reassurance offered to the mother.The baby should be given 1 mg.intramuscularly at birth.
Hepatology Highlights
Authors: Neil Kaplowitz
Journal: Hepatology (2003)

Murder in a Dysfunctional FamilyMutations in keratin (K) 8/18 have been associated with cryptogenic cirrhosis.Such mutations make hepatocytes very fragile so that necrosis occurs upon isolation.Knockout of either of these genes renders murine hepatocytes more sensitive to toxic drugs or immune-mediated killing via Fas death receptor.However, patients express mutant, dysfunctional keratins rather than their complete absence.Therefore, Ku et al. examined the susceptibility to apoptosis of transgenic mice overexpressing a keratin with a single point mutation, which causes the mutant keratin 18 (F22 and F50 mice) to act as a dominant negative compared with overexpression of wild-type keratin 18 (TG2 mice).Agonistic anti-Fas caused more rapid and severe liver injury (apoptosis and hemorrhage) (see Fig. ) and mortality in F22 and F50 mice.TNF/actinomycin D-induced liver injury, however, was the same in mice overexpressing mutant or wild-type keratin.The surface expression of Fas was not altered by the mutant keratin.Therefore, the mechanism for the differential, increased susceptibility to Fas but not to TNF-induced apoptosis has not been elucidated.It appears that genetic disturbances in the cytoskeletal keratin associated with cirrhosis are not simply a mechanical problem but may be caused by sensitization to Fas-mediated apoptosis by a mechanism requiring further study.
OXYGEN AND MUSCULAR FITNESS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum for the Research Article: “Long-gap peripheral nerve repair through sustained release of a neurotrophic factor in nonhuman primates” by N. B. Fadia, J. M. Bliley, G. A. DiBernardo, D. J. Crammond, B. K. Schilling, W. N. Sivak, A. M. Spiess, K. M. Washington, M. Waldner, H.-T. Liao, I. B. James, D. M. Minteer, C. Tompkins-Rhoades, A. R. Cottrill, D.-Y. Kim, R. Schweizer, D. A. Bourne, G. E. Panagis, M. Asher Schusterman II, F. M. Egro, I. K. Campwala, T. Simpson, D. J. Weber, T. Gause II…
Journal: Science Translational Medicine (2020)
Occupational Exposure to Environmental Tobacco Smoke: Results of Two Personal Exposure Studies
Authors: Roger A. Jenkins, Richard W. Counts
Journal: Environmental Health Perspectives (1999)

Personal monitoring is a more accurate measure of individual exposure to airborne constituents because it incorporates human activity patterns and collects actual breathing zone samples to which subjects are exposed.Two recent studies conducted by our laboratory offer perspective on occupational exposure to environmental tobacco smoke (ETS) from a personal exposure standpoint.In a study of nearly 1600 workers, levels of ETS were lower than or comparable to those in earlier studies.Limits on smoking in designated areas also acted to reduce overall exposure of workers.In facilities where smoking is permitted, ETS exposures are 10 to 20 times greater than in facilities in which smoking is banned.Service workers were exposed to higher levels of ETS than workers in white-collar occupations.For the narrower occupational category of waiters, waitresses, and bartenders, a second study in one urban location indicated that ETS levels to which wait staff are exposed are not considerably different from those exposure levels of subjects in the larger study who work in environments in which smoking is unrestricted.Bartenders were exposed to higher ETS levels, but there is a distinction between bartenders working in smaller facilities and those working in multiroom restaurant bars, with the former exposed to higher levels of ETS than the latter.In addition, ETS levels encountered by these more highly exposed workers are lower that those estimated by the Occupational Safety and Health Administration.Concomitant area monitoring in the smaller study suggests that area samples can only be used to estimate individual personal exposure to within an order of magnitude or greater.