tbuckley/cabot-search huggingface dataset:
The Medical Applications of the Short Wave Current.
Journal: Annals of Internal Medicine (1939)

AAINMDCLASCAONOUNL[u.13 its predecessors in the series, is based almost entirely on cases from the author 's own long experience in the prac- tice of surgery, and covers all of the conditions that the average surgeon i liable to encounter.As the author states in his introduction, no attempt has been made to include very rare conditions of which he has not had personal experience.The many illustrations and their excellent repro- duction are a valuable part of the text.The illustra- tions are all originaL Considering the technical difficul- ties of photography of, the moist buecal cavity, the author and his photographer, Mr. Barlow, are to be com- plimented on their achievements.The surgeon will find this book of practical aid in the recognition of the common surgical conditions
Future Perspectives in Physical Medicine and Rehabilitation
Authors: Leonard D. Policoff
Journal: JAMA (1966)

The specialty of physical medicine and rehabilitation has almost reached its majority, a 20-year period having elapsed since the founding of its qualifying specialty board. Despite the time lapse and a productive literature, an abysmal ignorance of the true capabilities, viewpoints, and techniques of the practitioners of this specialty and of the specialty itself continues to be widespread. The family physician, the specialist, and the academician seem to share equally a lack of understanding of the specialty of physical medicine and rehabilitation. For this, there would appear to exist a variety of reasons. Perhaps the most significant one is that of psychological orientation. <h3>Attitudes and Approach.—</h3> Physical medicine, and particularly that component of this specialty designated as rehabilitation, has boldly run contrary to the mainstream of medical attitudes as they exist today. This type of approach never makes for popularity. The physician in practice today, the academician teaching in the
Medical schools in the United States
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatorenal reflex regulating kidney function
Authors: Florian Lang, Edda Tschernko, Eva Schulze, Irina Öttl, Markus Ritter, Harald Völkl, Christian Hallbrucker, Dieter Häussinger
Journal: Hepatology (1991)

In anesthetized male rats, infusion of glutamine (2 μmol/min) into the superior mesenteric vein at a rate known to induce liver cell swelling leads to marked decreases in renal glomerular filtration rate, renal para-aminohippurate clearance and urinary flow rate. Glutamine infused at identical rates into the jugular vein does not elicit any of these effects. The effect of glutamine is mimicked by serine but not by glutamate. Spinal transection, renal denervation or section of the vagal hepatic nerves abolishes the effect of mesenteric venous glutamine infusion. Mesenteric application of glucagon (1 ng/min) or of both glutamine and glucagon enhances glomerular filtration rate and urinary flow rate. Infusion of 1 ng/min glucagon through the jugular vein does not significantly alter glomerular filtration rate or urinary flow rate. The data disclose a powerful liver-borne mechanism regulating kidney function that is mediated by the hepatorenal innervation. (Hepatology 1991;14:590-594.)
HLA and Disease: A Comprehensive Review.
Journal: Annals of Internal Medicine (1980)

This volume presents abstracts of the literature published during the first 10 years of realistic research into human viral hepatitis.Unfortunately, the abstracts have not been arranged chronologically, and this, taken together with the lack of an author index, means that finding a particular abstract can be difficult.This volume is of outstanding value to those working in the hepatitis field, and it is only to be re- gretted that more attention was not paid to the convenience of the user.
Infant Mortality Statistics
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Guide to Diseases of the Nose and Throat and Their Treatment.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Differential Tumor Immunogenicity of DBA/2 Mouse Lymphoma L1210 and Its Sublines. III. Control of Host Resistance to Drug-Resistant L1210 Sublines by &lt;italic&gt;H&lt;/italic&gt;-&lt;italic&gt;2&lt;/italic&gt;-Linked and Non-&lt;italic&gt;H&lt;/italic&gt;-&lt;italic&gt;2&lt;/italic&gt;-Linked Genes&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1983)

The effects of the host's genetic composition on the host's resistance to the DBA/2 L1210 lymphoma and three drugresistant L1210 sublines (which show an increased expression of tumor-associated antigens) were investigated. Histocompatible F, mice between DBA/2 and other mouse strains were given injections ip of graded numbers of these tumor cells. and a marked difference in the resistance of the host to tumor growth was demonstrated. The resistant hybrid mice showed markedly higher resistance to the L1210 sublines than to the L1210 parent lymphoma cells. Experiments with F1 mice between DBA/2 (H-22) and certain congeneic intra-H-2 recombinant strains showed that the H-2b/d heterozygosity at the H-2K+/-A regions and additional non-H-2 genetic factor(s) confer the resistance to the F1 mice. The resistance was abolished by treating host animals with injections of silica. an antimacrophage agent. or rabbit anti-mouse thymocyte serum. These results suggest that the resistance is immunologic and that the genetically controlled host resistance may be directed to surface changes related to the increased expression of tumor-associated antigens.
Identification of Elements of Urinary Sediment With Phase-Contrast Microscopy
Authors: Lita Brody
Journal: JAMA (1968)

Phase-contrast microscopy is now available for the routine study of urinary sediment. This technical development, first described by Zernike,<sup>1</sup>is easy to use, saves time, and allows us to recognize cells, casts, and other dejecta in the urine with a new order of precision and accuracy. Using bright-field microscopy, with or without stains, it takes a trained, interested nephrologist at least ten minutes to methodically scan the urinary sediment.<sup>2</sup>Less well-trained and less exacting physicians may spend less time at the microscope but usually they rely on junior technicians to report what they see. The physician's lack of confidence in his diagnostic ability is due to the optical limitations of bright-field microscopy, as we shall see. Because he cannot readily identify cells or casts with precision, he has a feeling that looking at the urinary sediment is a pointless exercise of little value to the patient and is
Hepatic Function in Acute Myocardial Infarction
Authors: Gopal Das
Journal: JAMA (1974)

Hepatic function was evaluated in 17 patients with acute myocardial infarction by measuring sulfobromophthalein retention, serum glutamic pyruvic transaminase level, lactic dehydrogenase (LDH ) hepatic isoenzyme, serum bilirubin value, and urinary urobilinogen excretion. Statistically significant alterations in the hepatic function were observed during the acute stage of the infarct as compared to the period following recovery. Hemodynamic changes in patients with acute myocardial infarction may play an important role in the genesis of altered hepatic function. (<i>JAMA</i>230:1558-1560, 1974)
Highlights from Recent Cancer Literature
Journal: Cancer Research (2015)

ATRX Mutations in Pheochromocytomas and ParagangliomasVery little is known about the somatic genomic changes leading to tumorigenesis and malignant progression in pheochromocytomas (PCC) and paragangliomas (PGL).Using whole-exome sequencing, Fishbein and colleagues identified somatic ATRX mutations in 12.6% of PCC/PGL tumors.ATRX is a member of the SWI/SNF family of chromatin remodelers and is known to play a role in human disease.Cancers with somatic ATRX mutations often have alternative lengthening of telomeres (ALT) as a mechanism of preventing senescence.In this study, the majority of samples with ATRX mutations showed ALT, albeit in a sample set underpowered to correlate ATRX function with outcome.The association between ATRX and other epigenetic alterations in both PCC/PGL and other human cancers where ATRX is mutated is an emergent area of investigation that may lend insight into epigenetic regulation and alternative therapeutic strategies.(Image by Alec Wilson, Hampton-in-Arden, UK, courtesy of Wikimedia Commons.)
Modification by Acetylcholine of the Response of Rat Mesenteric Arteries to Sympathetic Stimulation
Authors: KAFAIT U. MALIK, GEORGE M. LING
Journal: Circulation Research (1969)

The aim of this study was to determine the effect of varying concentrations of acetylcholine on the vasoconstriction of the perfused mesenteric arteries of the rat caused by stimulation of their sympathetic postganglionic nerves. Perfusion was carried out with a peristaltic pump, and the constriction caused by stimulation was measured by the rise of pressure in the cannula tied in the artery. Two effects were found. At rates of stimulation between 2 and 8/sec, acetylcholine added to the perfusion fluid in very low concentrations (50 pg/ml) caused an increase in the vasoconstriction. An increase was also caused by adding a concentration of 2 ng/ml for 15 seconds. If, however, this or a greater concentration was added for a longer time, it had the opposite effect and the vasoconstriction was greatly reduced or blocked. This reduction or block was not due in the main to a reduction or block of the vasoconstrictor action of norepinephrine. Block of response to stimulation was also produced by guanethidine. The block produced by acetylcholine resembled the block produced by guanethidine in two respects. The block was removed by raising the calcium concentration, and it was also removed by adding d -amphetamine to the perfusion fluid. The block produced by a given concentration of acetylcholine was abolished by a much higher concentration of atropine or hyoscine.
Letter: Nucleus hospitals.
Authors: A J Chapman
Journal: BMJ (1976)

intervertebral joint space widens.Hence intermittent or pulsating traction acts merely on muscles, evoking the stretch reflex but not the suction that determines the effect on the pro- trusion.The absolute contraindication to traction is acute lumbago.2Though pain and signs cease while the pull is maintained, the slightest diminution in tension causes such agonising twinges that it takes several hours to get the patient off the couch, and some aggravation
Neural Tube Defect Surveillance and Folic Acid Intervention--Texas-Mexico Border, 1993-1998
Journal: JAMA (2000)

Neural tube defects (NTDs) are common and serious malformations that originate early in pregnancy. In the United States, approximately 4000 pregnancies each year are affected by the two most common NTDs (spina bifida and anencephaly). In 1992, the Texas Department of Health (TDH), with support from a CDC cooperative agreement, implemented the Texas Neural Tube Defect Project (TNTDP), a program of NTD surveillance and risk-reduction activities in the 14 counties that border Mexico. The project was initiated in response to an anencephaly cluster identified during 1990-1991 in Brownsville (Cameron County), Texas (1). Whether the high anencephaly rate (19.7 per 10,000 live births) was unique to Cameron County or was characteristic of the entire border was unknown. This report summarizes NTD surveillance rates for the 14 Texas-Mexico border counties for 1993-1998 and presents preliminary results of TNTDP efforts to prevent the recurrence of NTDs by providing folic acid to high-risk women. Findings indicate that the baseline rate along the border is high (13.4 per 10,000 live births) and largely reflects the rate among Hispanics (13.8). Although a longer period is needed to obtain definitive results, folic acid appears to be effective for reducing the risk for NTD recurrence in Hispanics.
Is Micropapular Sarcoidosis Tuberculosis?
Authors: Hilary A Ridgway, Terence J Ryan
Journal: Journal of the Royal Society of Medicine (1981)

Three cases of micropapular sarcoidosis are reported. Two of the cases have a history of tuberculosis and all three cases have atypical patterns of Kveim and Mantoux reactivity. The similarities between this form of sarcoidosis and lichen scrofulosorum or lichenoid tuberculid are observed and the evidence is presented for a tuberculoid aetiology in certain forms of sarcoidosis.
POS0217 ALL-CAUSE AND CAUSE SPECIFIC MORTALITY AMONG PATIENTS WITH BEHCET’S DISEASE VERSUS GENERAL POPULATION
Authors: A. Shin, S. R. Choi, Y. J. Ha, Y. J. Lee, E. B. Lee, E. H. Kang
Journal: Annals of the Rheumatic Diseases (2022)

Background Behcet’s disease (BD) is a systemic vasculitis with multiorgan involvement. Objectives To compare the risk of all-cause and cause specific mortality among patients with BD compared to general population Methods Using the 2002-2017 Korea National Health Insurance database, we conducted a cohort study among BD patients compared to general population matched on age and sex at a 1:5 ratio. The primary outcome was death of any cause, and the secondary outcomes were cause-specific mortality for top 5 causes of death. Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs), comparing BD patients versus general population. Results The PS-matched study cohort (mean age 42.1 years; 32.0% male) included 32288 BD patients and 161440 controls. During a mean follow-up of 9.6 years, 2214 deaths occurred. The HR [95%] for all-cause mortality was 10.6 [9.6-11.6]. The Top 5 causes of death derived from malignancy, cardiovascular disease, infection, respiratory disease, and injury: the HR [95%] for mortality from these causes were 8.5 [7.2-10.1], 10.8 [8.6-13.6], 14.6 [8.1-26.3], 12.0 [8.5-17.0], and 8.0 [5.0-13.0], respectively. Conclusion This population-based cohort study warns exceptionally heavy burden of the disease showing approximately 10 times higher mortality of BD patients compared to general population. In line with this, risk of cause specific mortality was also significantly higher among the BD patients, for 5 top causes of death. Disclosure of Interests None declared
Papular clear cell hyperplasia of the eccrine duct in a diabetic
Authors: S. SIGNORETTI, G. ANNESSI, S. OCCHIUTO, P. RUATTI, T. FARAGGIANA
Journal: British Journal of Dermatology (1996)

We report a patient with a widespread papular disorder characterized by extensive clear cell hyperplasia of the secretory portion of the eccrine units. A 46‐year‐old woman had a long history of diffuse papules which gave the skin a ‘goose‐flesh’ appearance. She had severe diabetes. Histological examination of a papule showed marked clear cell hyperplasia that involved the secretory duct of all eccrine units present in the specimen sparing the secretory coil. The clear cells were periodic acid‐Schiff (PAS) positive and Alcian blue negative. Ultrastructural study confirmed that the clear cells contained abundant intracytoplasmatic glycogen. We suggest that the diabetic condition may be important in promoting the accumulation of glycogen in the eccrine ducts. Our patient represents a peculiar disorder of the eccrine units that, on the basis of clinicopathological features, we have termed papular clear cell hyperplasia of the eccrine duct
The Role of Physician-Owned Insurance Companies in the Detection and Deterrence of Negligence
Authors: William B. Schwartz
Journal: JAMA (1989)

This study presents evidence that physician-owned insurance companies and their physician members play an important role in the detection and deterrence of negligent behavior. A survey of physician-owned companies indicates that 94% involve their physicians in one or more aspects of the underwriting process. About 60% involve their members in assessing the competence of physicians who have been sued and in advising the underwriters on decisions concerning both continued insurability and the conditions of insurance. During 1985, a total of 0.66% of the physicians in physician-owned companies had their insurance terminated or were forced to give up their coverage because of negligence-prone behavior. An additional 0.7% of active policyholders were subject to restrictions on practice or other medical sanctions and 1.8% to surcharges and deductibles. Thus, disciplinary actions were in place against 3.2% of insured physicians whose performance was viewed as in some way substandard. The findings indicate that the physician-owned companies are effective agents in identifying negligence-prone behavior, and suggest that these companies also play an important role in deterring substandard performance. (<i>JAMA</i>. 1989;262:1342-1346)
The Dangerous Age in Men: A Treatise on the Prostate Gland
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Kinetics of Stem Cell Depletion and Proliferation: Effects of Vinblastine and Vincristine in Normal and Irradiated Mice
Authors: Willie W. Smith, Shirley M. Wilson, Sallie S. Fred
Journal: JNCI Journal of the National Cancer Institute (1968)

Vinblastine (VLB) caused a depression followed by an overcorrection in colony-forming units (CFU) of mice, as assayed by transplantation of spleen and marrow cells into irradiated recipients. Two days after VLB injection the femur showed a greater loss in nucleated cells than in CFU, resulting in a threefold increase in CFU concentration. The fraction of CFU recovered from the recipient spleen was 0.08 in these mice, compared to 0.20 for controls. On the basis of this lower transplantation fraction, the concentration of colony-forming cells in the femur is estimated to be 2/100 nucleated cells. Mice irradiated 2 days after an injection of VLB or vincristine showed a marked increase in endogenous splenic colonies and an early proliferative recovery of CFU. With VLB and 400 rads, exponential growth of femoral CFU began immediately, with no dip or lag phase apparent. This could not be attributed to an increased number of CFU at the time of irradiation or to a decreased radiation sensitivity. The effect was not seen in untreated mice given 200 rads, where the survival fraction was 7 times that for 400 rads. The CFU recovery pattern in mice pretreated with VLB appears therefore to result from a qualitative effect on the cells, which promotes early resumption of cell division after irradiation.
The Oregon Health Plan: To Cover All Diagnostic Visits
Authors: Richard C. Wopat
Journal: JAMA (1992)

<h3>To the Editor.</h3> —This letter is written in response to a previous letter to the editor from Dr Witten<sup>1</sup>and a response from Dr Eddy<sup>2</sup>published in the February 26, 1992, issue ofThe Journal. Both Witten's letter and Eddy's response indicate a lack of understanding of this aspect of the proposed Oregon Health Plan. Witten asks, "Are the patients expected to screen their visits to the physician according to whether or not the diagnosis is covered by Medicaid?" The proposed Oregon Health Plan covers all diagnostic visits. It was our philosophy that the decision as to whether treatment should be covered could not be made until the diagnosis was known; therefore, diagnostic visits and evaluations would be covered. In the examples that Witten and Eddy cited—diaper rash, pharyngitis, and superficial wounds—the patient could be seen by the doctor and a diagnosis could be made. That diagnostic visit