tbuckley/cabot-search huggingface dataset:
POS0991-HPR ADHERENCE TO THE MEDITERRANEAN DIET IS ASSOCIATED WITH A REDUCED DAS-28 INDEX AMONG PATIENTS WITH RHEUMATOID ARTHRITIS
Authors: B. Alawadhi, A. Alsaber, I. Shatawan, A. Al-Herz, P. Setiya, K. Saleh, A. Al-Awadhi, W. Al-Kandari, E. Hasan, K. Mokaddem, A. Ghanem, Y. Bartella, M. Hussain, N. Alhadhood, Y. Ali, E. Nahar, A. Aldei, A. Alenizi, S. H. M. Hayat, F. Abutiban
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> The Mediterranean diet (MedDiet) has been shown to have protective effects against the development and activity of Rheumatoid Arthritis (RA). It is hypothesized that changes in lifestyle which include diet may lead to the reduction of RA activity and progression. Dietary manipulations are commonly used to minimize RA symptoms by lowering inflammation. <h3>Objectives</h3> The aim of the present study was to assess the adherence of adult patients with RA from Kuwait to the MedDiet and its association with RA activity. <h3>Methods</h3> Adult patients who satisfied the American College of Rheumatology (ACR) classification criteria for RA from major hospitals in Kuwait were evaluated. A cross-sectional study conducted on 187 RA patients aged (35-82) years. DAS-28 scores were obtained in those patients. A validated 14-item Questionnaire (paper-based or web-based) given to the patients to measure adherence to MedDiet. Multivariate and univariate statistical techniques were utilized to analyze data. Statistical comparison and correlation were made in terms of MedDiet levels and RA disease activity by multivariant logistic regression. <h3>Results</h3> A total of 187 patients were included (median age 54 years; 140 males) with a median DAS-28 of 2.616. Out of 187 RA patients, 103 (55.1%) had lower MedDiet scores (MedDiet ≤ 5). Based on the logistic regression function, we found that The multivariable-adjusted odds ratio of RA patients with high adherence to the MedDiet (MedDiet ≥ 6) had lower DAS-28 scores (OR 5.34, 95% CI 1.176 - 24.230, P-value = 0.030) and improved lipid profiles compared to patients with low adherence. <h3>Conclusion</h3> Higher adherence to the MedDiet among Kuwaiti adults with RA may lead to improved DAS-28 scores. Lifestyle and dietary manipulations may be one of the non-pharmacological methods to control RA activity scores. <h3>Acknowledgements</h3> I would like to acknowledge Kuwait Registry for Rheumatic Diseases (KRRD), for providing us the needed data. <h3>Disclosure of Interests</h3> None Declared.
AB0619 PREDICTORS FOR FUTURE DEVELOPMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS IN KOREAN SJÖGREN’S SYNDROME PATIENTS
Authors: B. W. Lee, E. J. Kwon, Y. Park, J. J. Lee, S. H. Park, S. K. Kwok
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Sjögren's syndrome (SS) can occur alone or in combination with other autoimmune diseases. Systemic lupus erythematosus (SLE) is the most common autoimmune disease associated with SS. The prognosis of SS is generally better than that of SLE. However, the onset of SLE in these patients may be one of the factors that increase mortality. <h3>Objectives</h3> This study determined the impact of demographic factors, clinical manifestations, disease activity, and serological tests at baseline on future SLE development in Sjögren's syndrome (SS) patients. <h3>Methods</h3> This retrospective study assessed 1,082 SS patients without other autoimmune diseases at baseline who visited our hospital between January 2012 and March 2021. We analyzed demographic features, extra-glandular manifestations (EGMs), clinical indices, and laboratory values at baseline between the two groups divided per future SLE development (SS/SLE group vs. SS group). The probability and predictors of SLE development in SS patients were estimated using the Kaplan–Meier method and Cox proportional hazards models. <h3>Results</h3> The median follow-up duration was 1083.5 days. Forty-nine patients (4.5%) developed SLE that met the 2012 Systemic Lupus International Collaborating Clinics or 2019 EULAR/ACR classification criteria. The baseline EULAR SS disease activity index (ESSDAI) score was significantly higher in the SS/SLE group (<i>p</i>&lt;0.001). The SS/SLE group had more lymphadenopathy and renal involvement (<i>p</i>=0.015 and <i>p</i>=0.017, respectively). Shorter SS disease duration (&lt;3 years) (hazard ratio [HR]=2.61, <i>p</i>=0.012), high ESSDAI (HR=3.04, <i>p</i>=0.024), leukopenia (HR=2.20, <i>p</i>=0.017), hypocomplementemia (HR=17.40, <i>p</i>&lt;0.0001), and positive for anti-dsDNA (HR=19.93, <i>p</i>&lt;0.0001), anti-ribonucleoprotein (RNP) (HR=2.96, <i>p</i>=0.025), and anti-ribosomal P (HR=2.74, <i>p</i>=0.048) at baseline were SLE development predictors in SS patients. <h3>Conclusion</h3> Shorter disease duration and higher disease activity of SS at baseline may be risk factors for future SLE development. Serologic predictors of SLE development are hypocomplementemia, leukopenia, and positivity for anti-dsDNA, anti-RNP, and anti-ribosomal P antibodies. If the above factors are observed, close monitoring will be necessary during the follow-up period, considering the possibility of future SLE development. <h3>References</h3> [1]Lazarus MN and Isenberg DA. Development of additional autoimmune diseases in a population of patients with primary Sjogren's syndrome. <i>Ann Rheum Dis</i>. 2005; 64: 1062-4. [2]Pasoto SG, Adriano de Oliveira Martins V and Bonfa E. Sjogren's syndrome and systemic lupus erythematosus: links and risks. <i>Open Access Rheumatol</i>. 2019; 11: 33-45 <h3>Acknowledgements</h3> No acknowledgements to declare. <h3>Disclosure of Interests</h3> None Declared.
AB1511 HIGHER VASCULAR INVOLVEMENT IN BEHÇET’S DISEASE AMONG KURDISH ETHNICITY: DATA FROM A SINGLE CENTER AT INTERSECTION OF SILK ROAD IN EASTERN TURKEY
Authors: E. Oguz, M. Bektaş
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Behçet's disease (BD) is a chronic inflammatory multi-systemic disease that affect skin-mucosa, joints, eye and blood vessels. BD has some clinical differences in terms of disease manifestations and prognosis among Silk Road countries as well as various ethnicities. <h3>Objectives</h3> In this study, we aimed to evaluate the clinical features and course regarding cluster analysis of BD in Kurdish patients in Van provience, Eastern Turkey at the intersection of the silk road. <h3>Methods</h3> This retrospective observational study was carried out in a tertiarry reference center in Van province, East of Turkey. Patients data was obtained from their charts. All patients were asked about their ethnicity and patients with other ethnicities rather than Kurdish were also excluded from the study. Seven disease manifestations were included to the cluster analysis as follows; mucocutaneus findings (recurrent oral ulcer [ROU], genital ulcer [GU], pseudofolliculitis, erythema nodosum (EN)-like lesions, musculoskeletal (MSK) involvement (arthritis and spondylitis), gastrointestinal (GIS) involvement, vascular involvement (venous and/or artery), parenchymal central nervous system (CNS) involvement. <h3>Results</h3> We included 444 patients (of 59.2 % male) to the study. Mean±standard deviation (SD) of the patients was 35.8±10.2 years and median (Interquartile range [IQR]) disease duration was 12 [12]. Mean±SD age at initial symptom and age of diagnosis were 19.4±7 and 26.4±8.2, respectively. Fulfillment of ISG and ICBD criteria were 91.6 % and 96 %, respectively. Family history of Behçet disease and ROU were 35.4 % and 70.2 %, respectively. In cluster analysis, four clusters were observed as follow; 132 patients (31.2 %) in vascular (C1), 66 patients (15.6 %) in eye (C2), 60 patients (14.2 %) in musculoskelethal (C3) and 165 patients (39 %) in mucocutaneus (C4) clusters. Male gender (OR: 6.5, 95 % Confidence interval [CI]: 2-21.4), superficial thrombophlebitis (OR: 4.7, 95 % CI: 1.9-11.4) and uveitis (OR: 3.6, 95 % CI: 1.3-9.9) were associated with vascular involvement in multivariate analysis. <h3>Conclusion</h3> Among Kurdish patients with BD four disease clusters were observed. Parenchymal lung and CNS involvement were associated with vascular cluster. One third of patients had vascular involvement among Kurdish patients with BD which was quite higher compared to patients with Turkish ethnicity [1]. <h3>Reference</h3> [1]Tascilar K et al. Vascular involvement in Behçet's syndrome. PMID: 24907156. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
POS1010 MACROPHAGE EXTRACELLULAR TRAPS PROMOTE FIBROBLAST-LIKE SYNOVIOCYTES PROLIFERATION AND PROINFLAMMATORY CYTOKINE IN RHEUMATOID ARTHRITIS
Authors: W. Weng, Y. Jiang, S. Zhong, Y. Liang, Y. Pan
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Macrophage Extracellular Traps (METs) play an important role in the promotion of tissue injury, inflammation progression and autoimmune diseases. <h3>Objectives</h3> This study aims to investigate the effects of METs on the proliferation and expression of proinflammatory cytokines in fibroblast-like synoviocytes (FLS) in patients with rheumatoid arthritis (RA). <h3>Methods</h3> Synovial tissues of RA patients and traumatic controls undergoing joint replacement in our hospital were collected, and FLS of RA patients were cultured in vitro. Peripheral blood mononuclear cells (PBMC) were isolated from RA patients and differentiated into macrophages by M-CSF. The macrophages were co-cultured with serum of RA patients and healthy controls. SYTOX green, which stained the DNA released from cells and was a common method for detecting ETs, was added to observe the formation of METs. The expressions of CD68 and CitH3 in synovium were detected by immunofluorescence. METs were isolated and purified from THP-1 derived macrophages and co-incubated with FLS. The RNA expressions of proinflammatory cytokines TNF-a and IL-1β of RA-FLSs were detected by qPCR. The proliferation ability of RA-FLSs was detected by CCK-8 assay. <h3>Results</h3> We found the enrichment of macrophages labeled with CD68 and CitH3 in RA synovial tissues but not in traumatic controls. Immunofluorescence co-localization assay displayed that most CitH3 were distributed around CD68, suggesting that macrophages may be the main source of ETs (Figure 1A). PBMC induced macrophages co-incubated with serum from RA patients showed the formation of strip-like METs, while no obvious METs were observed with serum from healthy controls (Figure 1B). Purified METs were isolated and co-incubated with RA-FLSs for 48h. TNF-a and IL-1β were significantly overexpressed, and the proliferation of RA-FLSs was promoted (Figure 1C-D). <h3>Conclusion</h3> METs were detected in RA synovium but not in traumatic controls. The autoantibodies or inflammatory cytokines presented in the serum or RA patients may be associated with the increased METs formation in RA. In vitro experiments, METs could promote the proliferation and proinflammatory cytokines expression of RA-FLSs, suggesting that clearing or blocking the formation of METs may be a new therapeutic target for RA. <h3>Acknowledgements</h3> This work was supported by the Scientific and Technological Planning Project of Guangzhou City [202102020150], Guangdong Provincial Basic and Applied Basic Research Fund Project [2021A1515111172], National Natural Science Foundation of China Youth Fund [82201998], Third Affiliated Hospital of Sun Yat-Sen University Cultivating Special Fund Project for the National Natural Science Foundation of China [2022GZRPYQN01] and National Natural Science Foundation of China [82271849]. <h3>Disclosure of Interests</h3> None Declared.
AB0637 THE CLINICAL CHARACTERISTICS OF KOREAN PRIMARY SJÖGREN’S SYNDROME (pSS) PATIENTS WITH POSITIVE ANTI-DOUBLE-STRANDED DNA (ANTI-dsDNA) ANTIBODY BY THE FARR METHOD
Authors: E. J. Kwon, B. W. Lee, Y. Park, J. J. Lee, S. H. Park, S. K. Kwok
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Anti-Ro/SSA antibody is considered to play a crucial role in distinguishing the clinical features of pSS. However, the association of anti-dsDNA antibody on the characteristics and prognosis of pSS is not well known. <h3>Objectives</h3> We aimed to clarify the clinical characteristics of pSS patients presenting with positive anti-dsDNA antibody. <h3>Methods</h3> This retrospective study assessed 1255 pSS patients, fulfilling the classification criteria proposed by the American–European Consensus Group in 2002 or American College of Rheumatology/European League Against Rheumatism (EULAR) in 2016, who regularly visited Seoul St. Mary's Hospital between 2013 and 2021. Patients with other autoimmune diseases including SLE were excluded from this study. Of the total 1255 patients, 174 were in the anti-dsDNA antibody positive group (measured by using Farr assay, cut-off = 7 IU/ml) and 1081 were in the negative group. Data were compared between the two groups, including demographic features, extra-glandular manifestations (EGMs), clinical indices, and laboratory values at baseline. <h3>Results</h3> Patients in the anti-dsDNA (+) pSS group were younger (<i>p</i> = 0.015), and had higher proportion of positive finding in ocular staining score (OSS) by Sjögren's International Collaborative Clinical Alliance (SICCA) method (OSS ≥ 5) and minor salivary gland biopsy (Focus score ≥ 1) (<i>p</i> = 0.021 and <i>p</i> = 0.040, respectively). Among the EGMs, more frequent lymphadenopathy, lymphoma, pulmonary, cutaneous, renal, and CNS involvement were observed at baseline in the anti-dsDNA (+) pSS group. Total EULAR Sjögren's syndrome disease activity index (ESSDAI) scores were also higher in the anti-dsDNA (+) pSS group (median value [IQR]: 5.9 [5.1-6.7] vs 3.7 [3.4-3.9], <i>p</i> = 0.001). More frequency of leukopenia (<i>p</i> = 0.001), anemia (p = 0.001), rheumatoid factor positivity (p &lt; 0.001), anti-Ro/SSA antibody positivity (<i>p</i> &lt; 0.001), low C3 (<i>p</i> =0.024), low C4 (p=0.003) and hypergammaglobulinemia (<i>p</i> &lt; 0.001) were found in the laboratory data in the anti-dsDNA (+) pSS group. <h3>Conclusion</h3> Korean pSS patients with positive anti-dsDNA antibody by Farr method showed distinct clinical characteristics at baseline including higher disease activity of SS, frequent several types of EGMs, and difference of laboratory data. Close monitoring for development of above clinical features in anti-dsDNA positive pSS patients is necessary. <h3>Reference</h3> [1]Goules AV, Tzioufas AG. Primary Sjögren's syndrome: clinical phenotypes, outcome and the development of biomarkers. <i>Immunol Res</i>. 2017;65(1):331-344. <h3>Acknowledgements</h3> No acknowledgments to declare. <h3>Disclosure of Interests</h3> None Declared.
AB0731 CUTANEOUS AND ARTICULAR MANIFESTATIONS OF BEHÇET’S DISEASE
Authors: Y. Abid, R. Amri, H. Tounsi, S. Wafa, I. Chaabane, Z. Alaya
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Behçet's disease is a chronic inflammatory disease evolving by relapses whose etiopathogeny remains poorly elucidated. It is characterized by polymorphism and a clinical heterogeneity associating oral and genital aphthosis with systemic manifestations, notably cutaneous and articular. <h3>Objectives</h3> The aim of this study is to describe the epidemiological and clinical aspects of the articular and cutaneous-mucosal manifestations during Behçet's disease. <h3>Methods</h3> This was a monocentric, retrospective, and descriptive study. It was conducted over a period of 30 years and included all patients with Behcet's disease followed at the internal medicine department and meeting the international criteria for Behcet's disease. <h3>Results</h3> We collected 98 patients. A male predominance was observed (sex ratio of 2.5) with an average age of onset of the disease of 31 years. Familial forms were observed in 5.1%. Oral aphthosis was constant. The different localizations were on the inner side of the lip in 17 cases (68%), the inner side of the cheek in six cases (24%), the tongue in two cases (8%), and the gums in one case (4%). Genital aphthosis was found in 81 cases. Other manifestations were pseudofolliculitis (61 cases), erythema nodosum (7 cases), cutaneous aphthosis (4 cases), acneiform lesions (2 cases), cutaneous vasculitis (2 cases), and erythema multiforme (1 case). The pathergy test was performed in 30 cases. It was positive in 23 cases (76%). Joint involvement was present in 47 patients. The average age of diagnosis of joint involvement was 34 years. The mean time to diagnosis was 25 months. The involvement was peripheral in the majority of cases (95.7%), with the predominant site being the knees (67%). It was in the form of inflammatory arthralgias in 45 patients, associated with arthritis in 14 cases. Other manifestations were: low back pain (2 cases), sacroiliitis (1 case), bone erosion involving the hand (1 case), and popliteal cyst (1 case). <h3>Conclusion</h3> In Behçet's disease, the clinical manifestations are very polymorphic. Its polymorphic and non-specific clinical presentation can be a source of confusion with other pathologies. Cutaneous and articular manifestations are the most frequent. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1528 APPLICATION OF BONE MARROW EDEMA SCORING SYSTEM DERIVED ARTIFICIAL INTELLIGENCE IN RAPID RADIOGRAPHIC PROGRESSION RESCUE STUDY
Authors: K. Katayama, T. Okubo, K. Yujiro, T. Sato, T. Kawahata, K. Tanaka, S. Abe, H. Ito, K. Mori
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> We demonstrated new bone marrow edema (BME) scoring system in X-ray (specificity 90%, sensitivity 65-70%) using deep learning with artificial intelligence (AI) reflects MRI BME in previous EULAR meeting[1]. <h3>Objectives</h3> In this study, to ascertain whether BME score in this system by X-ray film might reflect MRI BME in Biologics therapy, we retrospectively applied this system to the rapid. radiographic progression rescue study previously reported[2]. <h3>Methods</h3> RA patients inadequate response with MTX who have extensive BME in single or bilateral wrist joints and DAS28-ESR&gt;3.2 were treated by enhanced group, of conventional synthetic (cs) DMARDs (26 patients) or by biologics (23 patients). X-ray film. of two groups after 3-6 months treatment applied to BME scoringsystem (cut off:0.4) and compared with MRI BME. <h3>Results</h3> J-PEG file of hand Xray film were uploaded to new BME scoring system(Figure 1). BME score are expressed as Positive or Negative and index [0-1]. In biologics group, number of BME score positive rate reduced from 65.3% to 15.3% after treatment in MRI BME improvement group and reduced 78.5% to 57.1% in MRI BME unchanged group(Table 1). In csDMARDs enhanced group, number of BME score positive rate reduced from 75% to 25% after treatment in MRI BME improvement group and reduced 59.7% to 53.1% in MRI BME unchanged group. In both groups, false negative (N: Figure 1, white color back) patients were observed. <h3>Conclusion</h3> AI-derived bone marrow edema score may reflect bone marrow edema in MRI in biologics treatment and may help early recognition of biologics efficacy during treatment. <h3>References</h3> [1]Katayama. K, ARD meeting supple AB 1335,2022 [2]Katayama. K, ARD meeting FRI 0124, 2018 <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
POS1262 ULTRASONOGRPHIC EVALUATION OF SALIVARY GLANDS IN PATIENTS WITH SYSTEMIC SCLEROSIS
Authors: A. Hafez, A. Moshrif, H. Aly, R. Abdelnoor, M. A. Mortada, R. Elkholi
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Although dry mouth is a common symptom in systemic sclerosis (SSc), there is a lack of studies evaluating the salivary glands in this heterogenous systemic disease. <h3>Objectives</h3> To study the ultrasonographic changes of salivary glands in patients with systemic sclerosis and to correlate these changes with disease activity markers, clinical data and autoantibodies. <h3>Methods</h3> Forty-seven SSc patients and forty-three healthy age and sex matched controls were studied. Duration of illness, sicca symptoms, Schirmer's test, joint symptoms, internal organ evaluation including interstial lung disease, pulmonary artery hypertension, Raynaud's phenomenon, digital pitting scars and the modified Rodnan total skin score. Laboratory investigations included acute phase reactants, antinuclear antibody, Anti-Ro-60/SSA, anti-La/SSB, anti-Topoisomerase 1 (anti–topo I) and anticentromere (ACA). Salivary glands were evaluated by ultrasound according to the most recent guidelines. <h3>Results</h3> The mean age of patients was 39.6±10.8 years with a mean disease duration of 5.1±4.3 years. Sicca symptoms were obvious among patients with SSc with significant difference compared to controls. pathological changes ≥2 was seen in 31 (66%) of the involved patients. The anti-topo 1 was seen to be significantly correlated with Doppler signals in the salivary glands (p=0.049) while the ACA and anti Ro were not found to be significant with any of the glandular pathology. Anti La was significantly correlated with pathological changes of the salivary glands (p=0.023). also, a significant correlation of anti-La and pathological changes in the submandibular and total gland score (p=0.03 and 0.045 respectively). <h3>Conclusion</h3> Ultrasonographic changes of the salivary glands are quite frequent in patients with SSc. The abnormalities are found correlating with the disease related autoantibodies especially anti La and anti topoisomerase antibodies. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.