PB2131: CLINICAL CHARACTERISTICS AND TREATMENTS OUTCOMES OF PRIMARY GASTROINTESTINAL LYMPHOMA:RETROSPECTIVE SINGLE CENTER STUDY FROM MOROCCO
Authors: E. Nora, E. mahtat, S. jennan, H. elmaaroufi, K. doghmi
Journal: HemaSphere (2022)

Background: Primary gastrointestinal lymphoma represents non-Hodgkin’s lymphoma(NHL) is the most common extra-nodal lymphoma. Aims: The aim of this work is to collect all of primary gastric lymphomas, in order to specify the characteristics epidemiological, clinical, paraclinical and therapeutic strategies. Methods: This is a descriptive retrospective study conducted in the clinical hematology department at the RABAT military hospital over a period of 20 years (2001 – 2021), We included all patients with primary digestive NHL (LPTD) with histological evidence Results: Our study focused on 74 cases of primary digestive NHL, an average of 3.7 cases/year, with a male predominance of 69% (sex ratio: 2.2) whose average age was 56 years with extremities of 15 at 80 years old. Performance status (PS) at diagnosis was between 0 and 1 in 64%.The functional symptomatology was dominated by abdominal pain; essentially gastric seat (86%) followed by transit disorders (28.5%) and digestive hemorrhage (27%). clinical examination found epigastric tenderness in 34% and tumor syndrome in 24%.General signs were present in 40%. The stomach was the predominant localization for LPTD (67.5%), followed by the colon (11%), the small intestine (7%) and the esophagus (3%) and finally the rectum and the liver (2.5%).).biological investigations found a microcytic hypochromic anemia in 54% of cases and a disturbance of the liver assessment in 11% of cases. The endoscopic appearance was an ulcero-budding process in 59.5% of cases, gastric infiltration (9.5%) and a large folds or polyploid mass (7%). Aggressive lymphoma was dominant in 80% of which large B-cell lymphoma presented the predominant histological form (67.5%), followed by marginal zone lymphoma (21.5%), Burkitt’s lymphoma (5.5%), mantle (7%), and 2 cases of T-cell lymphoma. The Hp status was determined in all patients, it was positive in 35% of cases. Extension assessment: it was localized forms (IE, II1E) in 50% of cases and disseminated forms (Ii2E to IV) in 47.5% of cases. 11% of patients were complicated by stenosis and/or occlusion.Therapeutically: Treatment based on immuno-chemotherapy with RCHOP (Rituximab- Cyclophosphamide- Doxorubicin- Oncovin- Prednisone) was the most used in first line (73% of cases), with an eradication treatment of Hp in 74% of cases, 10 patients required intensification by autograft, 21patients Were operated, and radiotherapy was indicated only in 2 patients for decompressive purposes. Treatment-related toxicity was mainly infectious (39%) and hematological (24%). At the end of our study, 63.5% of cases were in complete remission after 1st line treatment, 38% of patients died (75% by toxicity and 20% by progression), and 2 patients are undergoing treatment. Overall survival after median follow-up of 35 months was 124 months Summary/Conclusion: Primary digestive NHL is a rare lymphoma with a poor prognosis. epidemiological and clinical characteristics of our series are similar to those described in the literature