tbuckley/cabot-search huggingface dataset:
Fulminant hyperthermia during anesthesia and surgery
Authors: C. R. Stephen
Journal: JAMA (1967)

Rapid, progressive hyperpyrexia is becoming a cause for concern. It occurred in 12 patients, ten of whom failed to survive the acute episode. Conventional anesthetic drugs, including thiopental sodium, succinylcholine chloride, nitrous oxide, and halothane, were employed in most of the patients. No specific signs or symptoms heralded the onset of the hyperthermia. Usually the first observation was that the skin of the patient felt very hot; cardiovascular collapse developed shortly thereafter. At the moment, the primary treatment is prophylactic: continual monitoring of body temperature will detect beginning increases in body heat and permit efforts to reverse the situation before it becomes irreversible. When the syndrome develops, drastic measures must be instituted at once to reduce body temperature, provide high concentrations of oxygen with hyperventilation, and combat metabolic acidosis.
Saturated Fatty Acids in Vegetable Oils
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CELLULAR PATHOLOGY IN THE PAST AND IN THE FUTURE.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tamoxifen rechallenge.
Authors: P Pronzato, A Ardizzoni, R Lionetto, P F Conte, R Rosso
Journal: Journal of Clinical Oncology (1988)

AbstractApril 01, 1988 Share on Tamoxifen rechallenge.Authors: P Pronzato, A Ardizzoni, R Lionetto, P F Conte, and R RossoAuthors Info & AffiliationsPublication: Journal of Clinical OncologyVolume 6, Number 4https://doi.org/10.1200/JCO.1988.6.4.751 Get Access
Have quality improvement efforts decreased mortality rates following cardiac surgery?
Authors: E. D. Huff
Journal: JAMA (1997)

<h3>To the Editor.</h3> —In reporting no apparent difference between declining coronary artery bypass graft (CABG) surgery mortality rate trends in Massachusetts and in New York and northern New England, Dr Ghali and colleagues<sup>1</sup>have identified something that could be characterized as embarrassing or, at least, surprising. What makes their conclusions difficult to interpret is the absence of information about what did or did not systematically happen during the periods studied. It is apparent from the titles and content of the article by Ghali et al,<sup>1</sup>the accompanying Editorial by Dr Jencks,<sup>2</sup>and an earlier Editorial by Berwick<sup>3</sup>that these authors have assumed that concerted quality improvement efforts took place during the periods surveilled. That the distinctive improvement efforts of any locale constituted any sort of systematic or stable and sustained intervention for any interim period studied is not apparent after reading the source articles.<sup>4,5</sup>How
Moving Pieces
Authors: Lana R Elpert
Journal: Annals of Internal Medicine (2013)

On Being a Doctor19 March 2013Moving PiecesLana R. Elpert, MDLana R. Elpert, MDFrom Johns Hopkins Bayview Medical Center, Baltimore, Maryland.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-6-201303190-00012 Audio Reading - “Moving Pieces” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Moving Pieces," by L.R. Elpert. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail There are in every illness many days when the doctor can do nothing but wait.—Rainer Maria RilkeIt was raining the morning that I met Mr. F. He looked out the window, and in a tone dripping with frustration he announced that it was his 32nd day in the hospital. He did not seem proud of this particular achievement.At 80 years old, he had just been diagnosed with bladder cancer. A single dose of chemotherapy had unfortunately caused him to go into renal failure that required the initiation of hemodialysis. However, because the nephrologists were still hesitant to declare ... Author, Article, and Disclosure InformationAffiliations: From Johns Hopkins Bayview Medical Center, Baltimore, Maryland.Corresponding Author: Lana R. Elpert, MD, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Moving Pieces” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Moving Pieces," by L.R. Elpert. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 19 March 2013Volume 158, Issue 6Page: 495-496KeywordsAlcoholicsBladder cancerCardiovascular therapyChemotherapyGamesHeart diseasesHospitalizationsMemoryRenal diseasesRenal failure ePublished: 19 March 2013 Issue Published: 19 March 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Germany scores own goal on measles
Authors: None The Lancet Infectious Diseases
Journal: The Lancet Infectious Diseases (2006)

Now that the football World Cup is in full swing in Germany, the safety of visitors to the country might be expected to be among the highest of national priorities. Nevertheless, with eight national teams from the Americas competing in the tournament plus their accompanying supporters, the Pan American Health Organization (PAHO) has taken the extraordinary step of issuing a health advisory notice to travellers to the World Cup.
Das Denken und seine krankhaften Störungen.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Environmental Factors and Diseases of the Pancreas
Authors: Daniel S. Longnecker
Journal: Environmental Health Perspectives (1977)

The five major diseases of the pancreas together make a significant contribution to morbidity and mortality among the people of the United States. These diseases are diabetes, cystic fibrosis, acute and chronic pancreatitis, and carcinoma of the exocrine pancreas. Four of these diseases can be modeled in laboratory animals by acute or chronic administration of chemical poisons or carcinogens. Human pancreatic diseases attributed to the effect of chemical agents including alcohol and drugs include many cases of chronic pancreatitis and some cases of acute pancreatitis. The cause is not known in many cases of human pancreatitis, including interstitial, acute, and chronic clinical forms. Epidemiologic studies suggest that the increasing incidence of carcinoma of the exocrine pancreas in the United States may reflect chemical carcinogenesis. On the basis of experimental observations, we know that pancreatic islet cells can be damaged directly by toxic chemicals, and that islet cell tumors can be chemically induced. Thus, there is adequate background data to conclude that several pancreatic diseases of obscure etiology may be due in part to hitherto unidentified toxic effects of chemical agents encountered in personal or general environments.
Red blood cell mass and plasma volume changes in manned space flight
Authors: C. L. Fischer
Journal: JAMA (1967)

Plasma volume, red blood cell mass, and erythrocyte survival determinations were performed for the Gemini astronauts before and after Gemini orbital flights IV, V, and VII. Plasma volume decreases similar to those seen after bed rest and water immersion were found in Gemini IV and V. While each of these flights was affected by different stresses and the data accumulated are not as complete or extensive as desired, the results suggest that the plasma volume changes associated with the shorter flights may have been compensated for in the longer Gemini VII flight. These preliminary studies showed decreases in the survival of erythrocytes and red blood cell mass (both studied with sodium chromate Cr 51) in Gemini V and VII. No compensation for the RBC mass decrease was found even in the longer flight. Data obtained indicate decreased RBC mass is a result of mild hemolysis of unknown cause.
Contaminants and sea ducks in Alaska and the circumpolar region.
Authors: C J Henny, D D Rudis, T J Roffe, E Robinson-Wilson
Journal: Environmental Health Perspectives (1995)

We review nesting sea duck population declines in Alaska during recent decades and explore the possibility that contaminants may be implicated. Aerial surveys of the surf scoter (Melanitta perspicillata), white-winged scoter (M. fusca), black scoter (M. nigra), oldsqaw (Clangula hyemalis), spectacled eider (Somateria fischeri), and Steller's eider (Polysticta stellei) show long-term breeding population declines, especially the latter three species. The spectacled eider was recently classified threatened under the Endangered Species Act. In addition, three other diving ducks, which commonly winter in coastal areas, have declined from unknown causes. Large die-offs of all three species of scoters during molt, a period of high energy demand, were documented in August 1990, 1991, and 1992 at coastal reefs in southeastern Alaska. There was no evidence of infectious diseases in those scoters. The die-offs may or may not be associated with the long-term declines. Many scoters had elevated renal concentrations of cadmium (high of 375 micrograms/g dry weight [dw]). Effects of cadmium in sea ducks are not well understood. Selenium concentrations in livers of nesting white-winged scoters were high; however, the eggs they laid contained less selenium than expected based on relationships for freshwater bird species. Histological evaluation found a high prevalence of hepatocellular vacuolation (49%), a degenerative change frequently associated with sublethal toxic insult. Cadmium and selenium mean liver concentrations were generally higher in those birds with more severe vacuolation; however, relationships were not statistically significant. We do not know if sea duck population declines are related to metals or other contaminants.
Book Review Motivation and Visual Factors . By Irving E. Bender, A.M., Ph.D., Henry A. Imus, A.M., John W. M. Rothney, Ed.M., Ed.D., Camilla Kemple and Mary R. England. 8°, cloth, 369 pp. Hanover, New Hampshire: Dartmouth College Publications, 1942. $4.00.
Journal: New England Journal of Medicine (1943)
An epidemiologic study of contraception and preeclampsia
Authors: H. S. Klonoff-Cohen
Journal: JAMA (1989)

The primary hypothesis of this study was that contraceptive methods that prevent exposure to sperm and seminal fluid (condoms, diaphragms, spermicides, withdrawal) are associated with an increased risk of developing preeclampsia during the subsequent pregnancy. A case-control study was conducted comparing the contraceptive and reproductive histories of 110 primiparous women with preeclampsia with 115 pregnant women without preeclampsia, aged 15 to 35 years, who gave birth at North Carolina Memorial Hospital, Chapel Hill, between 1984 and 1987. Controls were frequency matched to cases by age, race, and distance from the hospital. Unconditional logistic regression analysis indicated a 2.37-fold (95% confidence interval, 1.01 to 5.58) increased risk of preeclampsia for users of contraceptives that prevent exposure to sperm. A dose-response gradient was observed, with increasing risk of preeclampsia for those with fewer episodes of sperm exposure. These results were supportive of the hypothesis that birth control methods that prevent sperm exposure may play a role in the etiology of preeclampsia. (<i>JAMA</i>. 1989;262:3143-3147)
Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease
Authors: O. V. Nikolskaia
Journal: Journal of Clinical Investigation (2006)

In this study we investigated why bloodstream forms of Trypanosoma brucei gambiense cross human brain microvascular endothelial cells (BMECs), a human blood-brain barrier (BBB) model system, at much greater efficiency than do T. b. brucei. After noting that T. b. gambiense displayed higher levels of cathepsin L–like cysteine proteases, we investigated whether these enzymes contribute to parasite crossing. First, we found that T. b. gambiense crossing of human BMECs was abrogated by N-methylpiperazine-urea-Phe-homopheylalanine-vinylsulfone-benzene (K11777), an irreversible inhibitor of cathepsin L–like cysteine proteases. Affinity labeling and immunochemical studies characterized brucipain as the K11777-sensitive cysteine protease expressed at higher levels by T. b. gambiense. K11777-treated T. b. gambiense failed to elicit calcium fluxes in BMECs, suggesting that generation of activation signals for the BBB is critically dependant on brucipain activity. Strikingly, crossing of T. b. brucei across the BBB was enhanced upon incubation with brucipain-rich supernatants derived from T. b. gambiense. The effects of the conditioned medium, which correlated with ability to evoke calcium fluxes, were canceled by K11777, but not by the cathepsin B inhibitor CA074. Collectively, these in vitro studies implicate brucipain as a critical driver of T. b. gambiense transendothelial migration of the human BBB.
The use of prisoners for medical research
Authors: R. E. Hodges
Journal: JAMA (1967)

The moral and ethical implications and the practical operating code we have developed in Iowa were described by one of us in a University of London lecture on July 14, 1967. The basic principles do not differ from those set forth in an address to the Central Society for Clinical Research in Chicago in 1951.<sup>1</sup>Since this aspect of our interest has been dealt with elsewhere, we will confine our comments to the practical aspects of using prisoners from custodial institutions in Iowa in our clinical research. In the last analysis, the introduction of any new form of diagnosis or treatment, any new drug or medicine, is an experiment. There must be a first. Our problem, therefore, is to determine to what degree experimentation on human subjects is permissible and what should be the strict lines of control and consent. In recent months and years, books have been written,
Death Rates by Occupation Based on Data of the U. S. Census Bureau, 1930
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BENJAMIN TRAVERS (1783-1858) OPHTHALMIC SURGEON
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Use of ACTH and Cortisone in Dermatology
Authors: John G. Downing
Journal: New England Journal of Medicine (1952)

DermatomyositisIn this disease the response to therapy, according to Bunim,56 depends on how far the changes have progressed. Some of them, — cellular infiltration, edema and induration, — are reversible. Others,—fibrinoid alteration and sclerosis of collagen, severe induration and atrophy of the skin and replacement of fat and muscle by fibrous connective tissue, — are irreversible. In the single case reported by Bunim, the response to ACTH was fairly good. The skin lesions improved and the patient's dysphagia decreased, but the muscle weakness and electrocardiographic changes persisted.O'Leary and his group37 treated 3 patients with dermatomyositis, acute in 1 . . .
MEMBRANOUS ANGINA DUE TO OTHER MICRO-ORGANISMS THAN DIPHTHERIA BACILLI.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Distinct features of the portalhypertensive syndrome in patients with advanced chronic liver disease due to non-alcoholic steatohepatitis
Authors: Rafael Paternostro, Wilhelmus Kwanten, Jeannette Becker, Benedikt Hofer, Vera Panagl, Helena Schiffke, Luisa Vonghia, Thomas Vanwolleghem, Ali Bagdadi, Benedikt Simbrunner, Georg Semmler, Philipp Schwabl, Bernhard Scheiner, Theresa Bucsics, David JM Bauer, Ernst Eigenbauer, Michael Trauner, Mattias Mandorfer, Sven Francque, Thomas Reiberger
Journal: Journal of Hepatology (2020)