Antacids
Authors: WILLIAM J. MARTIN
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 July 1981AntacidsWILLIAM J. MARTIN, PHARM. D., CHARLES W. LLOYD, PHARM. D.WILLIAM J. MARTIN, PHARM. D.Search for more papers by this author, CHARLES W. LLOYD, PHARM. D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-1-118 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest Drs. Drake and Hollander's article on antacid neutralizing capacity and cost effectiveness (1). They ascertained the neutralizing capacity of 1 mL of a wide range of antacids using Fordtran's method and calculated the volume of each antacid needed to neutralize 140 meq of a 0.1-N HCL solution. This article leaves the reader, however, with the impression that 140 meq of acid-neutralizing capacity must be achieved for effective treatment of uncomplicated peptic ulcer disease.Recommendations by Littman and Pine (2), Myhill and Piper (3), and others suggest that the antacid dose be enough to...References1. DRAKEHOLLANDER DD. Neutralizing capacity and cost effectiveness of antacids. Ann Intern Med. 1981;94:215-7. LinkGoogle Scholar2. LITTMANPINE AB. Antacids and anticholinergic drugs. Ann Intern Med. 1975;82:544-51. LinkGoogle Scholar3. MYHILLPIPER JD. Antacid therapy of peptic ulcer: Part I: A mathematical definition of an adequate dose. Gut. 1964;5:581-9. CrossrefMedlineGoogle Scholar4. STURDEVANTWALSH RJ. Duodenal ulcer. In: SLEISENGER MH, FORDTRAN JS, (eds). Gastrointestinal Disease. 2nd ed. Philadelphia: W. B. Saunders; 1978:854. Google Scholar5. PETERSONSTURDEVANTFRANKL WRH. Healing of duodenal ulcer with an antacid regimen. N Engl J Med. 1977;297:341-5. CrossrefMedlineGoogle Scholar1. PETERSONSTURDEVANTFRANKL WRH. Healing of duodenal ulcer with an antacid regimen. N Engl J Med. 1977;297:341-5. CrossrefMedlineGoogle Scholar1. DRAKEHOLLANDER DD. Neutralizing capacity and cost effectiveness of antacids. Ann Intern Med. 1981;94:215-7. LinkGoogle Scholar2. FORDTRANMORAWSKIRICHARDSON JSC. In vivo and in vitro evaluation of liquid antacids. N Engl J Med. 1973;288:923-8. CrossrefMedlineGoogle Scholar3. Antacid monograph. Fed Register. 1974;39 (4 June):19862. Google Scholar1. FORDTRANMORAWSKIRICHARDSON JSC. In vivo and in vitro evaluation of liquid antacids. N Engl J Med. 1973;288:923-8. CrossrefMedlineGoogle Scholar1. DRAKEHOLLANDER DD. Neutralizing capacity and cost effectiveness of antacids. Ann Intern Med. 1981;94:215-17. LinkGoogle Scholar2. DUTROAMERSON MA. Comparison of liquid antacids. N Engl J Med. 1980;302:967. CrossrefMedlineGoogle Scholar3. HARVEY S. Gastric antacids and digestants. In: GILMAN AG, GOODMAN LS, GILMAN A, eds. The Pharmacologic Basis of Therapeutics. New York: MacMillan; 1980:991. Google Scholar4. . Antacid products for over-the-counter human use. In: Code of Federal Regulations. Title 21, Part 331. Washington, D.C.: Food and Drug Administration; 1979:152-7. Google Scholar5. FORDTRANMORAWSKIRICHARDSON JSC. In vivo and in vitro evaluation of liquid antacids. N Engl J Med. 1973;288:923-8. CrossrefMedlineGoogle Scholar1. DRAKEHOLLANDER DD. Neutralizing capacity and cost effectiveness of antacids. Ann Intern Med. 1981;94:215-7. LinkGoogle Scholar2. KASTRUPBOYD EJ, eds., Facts and Comparisons. St. Louis: Facts and Comparisons, Inc.; 1963. Google Scholar3. FORDTRANMORAWSKIRICHARDSON JSC. In vivo and in vitro evaluation of liquid antacids. N Engl J Med. 1973;288:923-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Houston College of Pharmacy Houston, TX 77030 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1981Volume 95, Issue 1Page: 118-120KeywordsHydrochloric acidPeptic ulcers Issue Published: 1 July 1981 PDF DownloadLoading ...