tbuckley/cabot-search huggingface dataset:
THE DUTY OF THE PHYSICIAN TO THE STATE.
Journal: JAMA (1901)

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The Dynamics of Living Matter.
Journal: JAMA (1906)

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Traité de physiologie normale et pathologique. Publié sous la direction G.-H. Roger, professeur de physiologie à la Faculté de médecine de Paris, et Léon Binet, professeur agrégé de physiologie à la Faculté de médecine de Paris. Tome XI. Reproduction et croissance.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
'Silent ischemia' challenges diagnostic, treatment skills
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Polyhalogenated Aromatic Compounds on Porphyrin Metabolism
Authors: Robert H. Hill
Journal: Environmental Health Perspectives (1985)

Heme production is a vital metabolic process that occurs in the bone marrow and liver. Porphyrins are unused by-products of this biosynthetic process and normally occur in urine and other body fluids in low concentrations. Various disorders can disrupt the heme biosynthetic process, causing greater quantities of porphyrins in urine. The porphyrias are a group of diseases characterized by excessive porphyrins and other precursors in urine. Porphyrias may be either hereditary or acquired through exposure to certain drugs or chemicals. Porphyria cutanea tarda (PCT) is the disease associated with exposure to polyhalogenated aromatic compounds. The urinary porphyrin pattern is of great value in diagnosing PCT and defining the etiology of the disease. As this liver disease from chemical damage develops, the urinary pattern progressively changes. With the development of a rapid and sensitive high-performance liquid chromatography analysis, urinary porphyrin patterns can be easily monitored. All free porphyrin acids can be quantitatively analyzed in less than 15 min. In our studies of groups exposed to porphyrinogenic chemicals, we have not observed clear differences in the urinary porphyrin patterns of cases when compared with carefully selected controls. In animal studies, however, PCT was clearly associated with polybrominated biphenyl exposure. Future evaluation of the utility of urinary porphyrin patterns as a diagnostic tool will require a cohort that has received a recent, well-documented exposure and a comparable control population. Assay of erythrocyte uroporphyrinogen decarboxylase activity will also be needed to define the form of the PCT.
Azathioprine treatment of immunological renal disease
Authors: D. A. Adams
Journal: JAMA (1967)

Observations over 2 to 14 months in 19 adults with various unrelenting renal diseases considered to have immunological basis suggest that azathioprine (Imuran) combined with high doses of prednisone may have value in treating certain of these disorders. Good results occurred in steroid-resistant or steroid-intolerant nephrotic syndrome, particularly with minimal pathological glomerular changes. In lupus nephritis, the condition of three of four patients improved when steroids alone had been ineffective. In subacute and chronic glomerulonephritis a few patients experienced improvement, but the condition of most was unchanged or worse. Where steroidal side effects were a problem, azathioprine allowed a reduction or discontinuance of steroids, with continuing favorable results. Hematological and gastrointestinal symptoms were the major side effects encountered, and were not severe except in patients with advanced renal failure.
Imported tularaemia.
Authors: J B Wood, K Valteris, R H Hardy, A D Pearson
Journal: BMJ (1976)

Carotid shudder as a sign of ascending aorta dissection A coarse shudder in the carotid arterial pulse is sometimes associated with aortic cusp rupture, but it is not described as a physical sign of dissection of the ascending aorta in standard cardiological text- books.'-4We report its presence in two cases of dissecting aneurysm, in one of which it was of diagnostic value. Case reportsA previously well 28-year-old man was admitted with severe central chest pain to the Royal Devon and Exeter Hospital under the care of Dr D B Shaw. Significantly, his mother had died of a ruptured aorta.He had florid skeletal stigmata of Marfan's syndrome.There were signs of free aortic regurgitation but none, either clinical or electrocardiographic, of left ventricular hyper- trophy, suggesting that the lesion was acute.There was no evidence of myocardial infarction.Chest x-ray examination showed no mediastinal widening, but clearly dissection of the aorta at its root had occurred.The patient was transferred to the Wessex Regional Cardiac Centre, where, in addition to the above findings, a coarse shudder in the carotid arterial pulse was noted.Angiography showed the dissection and severe aortic regurgitation, and a free moving edge of torn media and intima was seen as a linear shadow within the ascending aorta.At operation (Mr J M Monro) the ascend- ing aorta was replaced by a Dacron prosthesis and the aortic valve by a Bjork Shiley prosthetic valve.Postoperative recovery was uneventful.In the second case, seen only two days after the first, the patient, a 51-year- old man, had attended outpatients with mild angina three years previously.His physical signs were therefore documented.The day before admission he had had transient central chest pain.This recurred more severely the next morning.By admission to the Wessex Regional Cardiac Centre with a pro- visional diagnosis of myocardial infarction, despite a normal electrocardio- gram, he was hypotensive but there were no abnormal signs in the heart and, in particular, no evidence of aortic regurgitation.A coarse shudder was felt in the carotid pulse, however, and, remarkably, it varied in intensity.Although the mediastinal width in an x-ray film taken by a-portable machine was within normal limits, the diagnosis of dissection seemed likely, and, with the experience of the first patient freshly in mind, the carotid shudder suggested that it was the ascending aorta.Since the aortic valve was not affected conservative measures were adopted, but next day signs of severe aortic regurgitation appeared.Angiography confirmed dissection of the
Reasons for decrease in sexual activity among homosexual men with HIV infection
Authors: J. E. Kaplan
Journal: JAMA (1988)

<h3>In Reply.—</h3> Drs Kell and Techman treat methadone maintenance patients in a private clinic with substantial involvement by physicians, who see the patients at least once per week and personally dispense medication. We applaud this degree of physician involvement and we agree that approaches using psychotherapy and self-help, as exemplified by Alcoholics Anonymous,<sup>1</sup>can be useful for individual methadone maintenance patients. Nevertheless, we believe that our article on the treatment of stable, long-term methadone maintenance patients by hospital-based physicians, has been misinterpreted. First, we disagree that dispensing a 28-day supply of take-home medication to patients who have demonstrated years of responsible behavior is a liability. Diversion of methadone for resale is extremely unlikely because our patients take a dose of methadone in the physician's office to ensure tolerance. Also, few incidents of lost medication have occurred, and our patients all have legitimate sources of income. Second, the description of
Abdominal pain in diabetic metabolic decompensation. Clinical significance
Authors: I. W. Campbell
Journal: JAMA (1975)

Severe abdominal pain and tenderness occurred in 46 of 211 episodes of severe diabetic metabolic decompensation. No association was found between abdominal pain and the degree of dehydration or the initial blood glucose level. In 17 instances, the abdominal pain could be attributed to the precipitating cause of the metabolic decompensation. The episodes of unexplained pain all occurred in insulin-dependent patients less than 40 years of age; of these, only three had a plasma bicarbonate level &gt;10 mEq/liter, and in two patients, additional factors could account for the relative lack of ketoacidosis. Abdominal pain occurring in patients more than 40 years old, irrespective of the plasma bicarbonate level, and in patients of any age with a plasma bicarbonate level in excess of 10 mEq/liter, almost invariably indicates a specific underlying cause. (<i>JAMA</i>233:166-168, 1975)
A Handbook for Senior Nurses and Midwives.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Obstetrics and gynecology
Authors: A. C. Wentz
Journal: JAMA (1994)

Contraceptive development has taken a new direction in the face of the acquired immunodeficiency syndrome epidemic, the high incidence of teenage pregnancy, and the need for acceptable, female-controlled family planning methods. Sexually transmitted diseases (STDs) are a particular problem, as women suffer most of their consequences, including pelvic inflammatory disease, infertility, and tubal pregnancy. Heterosexual transmission of human immunodeficiency virus (HIV) accounts for the alarming increase in its incidence in reproductive-age women. Thus, new contraceptive strategies must be sought. Needed is a safe, female-controlled method that would be effective in preventing both pregnancy and the transmission of STDs, including HIV. The female condom is a welcome addition, but its contraceptive and STD prevention efficacy need further study. There is an 11% to 15% rate of accidental pregnancy at 6 months for women who use the the female condom (similar to rates for other barrier contraceptive methods for women); however, rates
Council On Occupational Health
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CORRECTION
Journal: Annals of the Rheumatic Diseases (2005)

Words were omitted from the legend of fig 2 of this article.The correct legend is:''Improvement of inflammatory spinal lesions in a patient with AS in the T 1 /Gd-DTPA MRI sequence before (A) and after (B) treatment with etanercept.The hyperintensity of the signal in the vertebra is no longer detectable after 6 weeks of treatment with etanercept.''Similarly, the legend on the first Contents page of this issue of the Annals referring to the figure on the front cover should be:'''Spinal lesions in a patient with ankylosing spondylitis before (A) and after (B) etanercept''.
OS9.3 Clinical, molecular and radiomic profile of gliomas with FGFR3-TACC3 fusion
Authors: A Picca, A Alentorn, E Saragoussi, F Bielle, F Ducray, C Villa, Y Schmitt, J Lerond, J Leclerc, A Lasorella, A Iavarone, K Mokhtari, J Savatovsky, M Sanson, A Di Stefano
Journal: Neuro-Oncology (2019)

Abstract PURPOSE Actionable oncogenic fusion FGFR3-TACC3 (F3T3) is found in 3% of gliomas. Our goal was to characterize the clinical, radiological and molecular features of patients with F3T3-positive glioma. PATIENTS AND METHODS Overall, we screened 1112 gliomas by RT-PCR (861 WHO grade IV, 140 grade III and 111 grade II) and identified 50 F3T3-positive cases. We performed a radiological and radiomic case control study. RESULTS F3T3 fusion was exclusively found in IDH wild-type gliomas. F3T3 was mutually exclusive with the EGFR amplification (0/38 versus 143/336 of F3T3-negative cases, P=0.01), whereas it was associated with CDK4 amplification (7/33 versus 22/321 of F3T3-negative cases, P=0.04) and MDM2 amplification (6/33 versus 15/354 of F3T3-negative cases, P=0.03). F3T3-positive gliomas showed a longer overall survival than F3T3-negative gliomas (median OS 40.1 and 20.0 months, P=0.02), particularly in the grade IV subgroup (40.1 versus 19.0 months, P=0.006). Multivariate analysis showed that F3T3 fusion is an independent predictor of favorable outcome for glioblastoma patients. F3T-positive gliomas were associated with involvement in non-eloquent areas (r=0.31 P=0.007), cortico-subcortical regions and insula involvement (adjusted p&lt;0.001), poorly defined enhancing margins (r=0.48 P&lt;0.001), poorly defined non-enhancing margins (r=0.61 P&lt;0.001), and higher proportion of edema (r=0.43 P&lt;0.001). Radiomics analysis correctly classified F3T3-positive glioma with an AUC of 0.82. We compared different Cox proportional hazards models using Harrel’s C-Index. Although radiomics alone obtained a high C-Index (0.75, SD 0.04), the model combining clinical, genetic and radiomic data showed the highest C-index (0.81, SD 0.04). CONCLUSION Gliomas harboring F3T3 gene fusions show specific molecular features, distinct radiological and radiomic features and a less aggressive clinical evolution.
Aspirin for Prevention of Stroke and Cardiovascular Events Among Patients With Peripheral Artery Disease—Reply
Authors: John M. Kittelson
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis
Authors: Franck Oury, Mathieu Ferron, Wang Huizhen, Cyrille Confavreux, Lin Xu, Julie Lacombe, Prashanth Srinivas, Alexandre Chamouni, Francesca Lugani, Herve Lejeune, T. Rajendra Kumar, Ingrid Plotton, Gerard Karsenty
Journal: Journal of Clinical Investigation (2014)

In the original article, the substitution mutation in GPRC6A at F464Y was erroneously described as located in one of the transmembrane domains of GPRC6A; however, the F464Y mutation is located in the long N-terminal region of GPRC6A (1-594AA).This error affected portions of the text in the Abstract, Introduction, Results, and Discussion.The corrected sentences appear below. Abstract (page 2421):To determine the importance of osteocalcin in humans, we analyzed a cohort of patients with primary testicular failure and identified 2 individuals harboring the same heterozygous missense variant of GPRC6A, which prevented the receptor from localizing to the cell membrane.
Immunosuppressive therapy using antithymocyte globulin, cyclosporine, and danazol with or without human granulocyte colony-stimulating factor in children with acquired aplastic anemia
Authors: Seiji Kojima, Shigeyoshi Hibi, Yoshiyuki Kosaka, Masuji Yamamoto, Masahiro Tsuchida, Hideo Mugishima, Kanji Sugita, Hiromasa Yabe, Akira Ohara, Ichiro Tsukimoto
Journal: Blood (2000)
Cover sheet for index
Authors: Jeffrey Bernhard, Thomas Cropley, Karen Wiss, Andrew Blauvelt, Ponciano Cruz, Jane Grant-Kels, Nathaniel Jellinek, Timothy Johnson, Ann Arbor, Alexandra Kimball, Marta Petersen, Martin Weinstock, Michael Bigby, Jean Bolognia, New Haven, Luis Diaz, Chapel Hill, Mark Lebwohl, New York, Donald Miech, Wisconsin Ginat, W Mirowski, Scott Norton, Maryland Olsen, Carolina Orringer, Amy Paller, J Smith, Richard Dobson
Journal: Journal of the American Academy of Dermatology (2006)
THE ANTISCORBUTIC POTENCY OF CERTAIN FOODS
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal