tbuckley/cabot-search huggingface dataset:
Cigarette Smoking Among Adults--United States, 1997
Journal: JAMA (1999)

One of the national health objectives for 2010 is to reduce the prevalence of cigarette smoking among adults from 24% in 1998 to < or = 12% (objective 27.1a). To assess progress toward this objective, CDC analyzed self-reported data from the 1999 National Health Interview Survey (NHIS) about cigarette smoking among U.S. adults. This report summarizes the findings of this analysis, which indicate that, in 1999, approximately 23.5% of adults were current smokers, representing a modest decline in prevalence since 1993. If states were to invest resources consistent with CDC recommendations and implement proven interventions, the decline in cigarette smoking could be accelerated.
Вікові особливості вмісту окремих про- та протизапальних цитокінів у крові хворих на цироз печінки невірусної етіології
Authors: V.P. Prysyazhnyuk
Journal: GASTROENTEROLOGY (2014)

Вивчено вікові особливості вмісту фактора некрозу пухлин α, інтерлейкіну-4 та трансформуючого фактора росту β1 у крові у хворих на цироз печінки та їх взаємозв’язки з біохімічними маркерами ушкодження печінки. Виявлено, що у хворих на цироз печінки невірусного походження суттєвих змін зазнає цитокінова система, що проявляється в збільшенні концентрації фактора некрозу пухлин-α і трансформуючого фактора росту β1 у плазмі крові порівняно з практично здоровими людьми та віковим зростанням рівня зазначених цитокінів. Уміст інтерлейкіну-4 в крові пацієнтів із цирозом печінки був знижений порівняно з контрольними показниками, вікових особливостей концентрації цитокіну в крові не виявили. Встановлені кореляційні зв’язки між умістом прозапальних цитокінів та біохімічними маркерами цитолітичного, холестатичного та мезенхімально-запального синдромів вказують на вагому роль цитокінової ланки імунної системи в розвитку та прогресуванні цирозу печінки.
Nasal Cavity Neoplasia in F344/N Rats and (C57BL/6 × C3H)F&lt;sub&gt;1&lt;/sub&gt; Mice Inhaling Propylene Oxide for up to Two Years&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Renne, R. A., Giddens, W. E., Boorman, G. A., Kovatch, R., Haseman, J. E., Clarke, W. J.
Journal: JNCI Journal of the National Cancer Institute (1986)

Journal Article Nasal Cavity Neoplasia in F344/N Rats and (C57BL/6 × C3H)F1 Mice Inhaling Propylene Oxide for up to Two Years Get access R. A. Renne, R. A. Renne Search for other works by this author on: Oxford Academic PubMed Google Scholar W. E. Giddens, W. E. Giddens Search for other works by this author on: Oxford Academic PubMed Google Scholar G. A. Boorman, G. A. Boorman Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Kovatch, R. Kovatch Search for other works by this author on: Oxford Academic PubMed Google Scholar J. E. Haseman, J. E. Haseman Search for other works by this author on: Oxford Academic PubMed Google Scholar W. J. Clarke W. J. Clarke Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 77, Issue 2, August 1986, Pages 573–582, https://doi.org/10.1093/jnci/77.2.573 Published: 01 August 1986 Article history Received: 06 January 1986 Accepted: 23 April 1986 Published: 01 August 1986
Placing the Pacing Wires
Authors: W. G. Fuqua
Journal: JAMA (1972)

<h3>To the Editor.—</h3> As our coronary care unit of seven beds is located on a different floor from the x-ray department, it was quite difficult and potentially hazardous to transport our coronary care patients to the x-ray department for the placement of pacing wires. To avoid this, we passed several pace wires with the use of intra-atrial electrocardiographic monitoring. While this worked well for a fair number of cases, because of artifact and because of patients who had atrial fibrillation, many times this was not successful either. During the past four years, on 42 occasions, the pace wire has been passed by us without either of the two above-mentioned methods, but by a procedure that I term "fishing." This procedure is characterized by putting the pace wire into the basilic vein, preferably with a cut-down method, then turning the pace voltage to 5 to 7 mv, thereby watching the muscle
Ice Cream in the Diet of Insulin-Dependent Diabetic Patients
Authors: David M. Nathan
Journal: JAMA (1984)

We investigated the effect of ice cream ingestion on blood glucose control in conventionally treated and intensively treated insulin-dependent (type I) diabetic patients. After the ingestion of 100 g of ice cream, plasma glucose excursions as measured by the peak increment (90± 30 mg/dL) and area under the curve (166±59 mg/dL X hour) were modest and not significantly different between the subgroups of intensively treated and conventionally treated diabetics. A small dose (3 to 5 units) of rapid-acting insulin given 30 minutes before ingestion of ice cream reduced the modest plasma glucose excursion. A modest amount of ice cream may be included in weight-maintaining diets of insulin-dependent diabetics. Small doses of rapid-acting insulin prevent any adverse effect of the ice cream on blood glucose control. (<i>JAMA</i>1984;251:2825-2827)
Risk of Cross-Infection Through Shared Diabetic Devices
Authors: Peter Shalit
Journal: JAMA (1990)

<h3>To the Editor.—</h3> A recent incident has made us aware of inadequate patient instructions accompanying diabetic devices. A 43-year-old woman positive (by enzyme-linked immunosorbent assay and Western blot testing) for human immunodeficiency virus indicated to us that since 1981 she has screened several friends and relatives for diabetes by performing finger-stick blood glucose determinations on them. She routinely uses a single disposable lancet to draw blood from several individuals, including herself, in rapid succession without disinfecting the lancet. Four such individuals have been tested and are negative for human immunodeficiency virus. After finding that the labeling of the lancets and holder used by our patient had no warning against sharing used instruments, we surveyed the major local pharmacy chains to evaluate labeling of diabetic devices. Of five brands of lancets, six lancet holders, and three brands of insulin syringes, only one brand of lancet and two holders warned against use
Handbuch der mikroskopischen Anatomie des Menschen.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Further Characterization of the WI-L1 and WI-L2 Lymphoblastoid Lines
Authors: Jay A. Levy, Donald N. Buell, Charlotte Creech, Yashar Hirshaut, Herriette Silverberg
Journal: JNCI Journal of the National Cancer Institute (1971)

The WI-L1 and WI-L2 lymphoblastoid lines are further characterized. WI-L1 originally harbored the Epstein-Barr (EB) virus, which, however, disappeared after 6 months in culture. No other virus infection could be detected in any of the cell lines. Antibodies to EB virus were demonstrated in both cell line donors and in the entire family of the WI-L2 donor, which suggests that EB virus may have been a factor in the easy establishment of the cell lines. A subline of cells from WI-L1 with a unique #1 chromosome marker has been established. Both WI-L1 and WI-L2 cell lines have a significant production of immunoglobulins.
Expression and regulation of G1 cell-cycle inhibitors (p16INK4A , p15INK4B, p18 INK4C, p19INK4D ) in human acute myeloid leukemia and normal myeloid cells
Authors: J Schwaller, Th Pabst, HP Koeffler, G Niklaus, P Loetscher, MF Fey, A Tobler
Journal: Leukemia (1997)
A Text-Book of Pathology: An Introduction to Medicine
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of Anchorage in the Expression of Tumorigenicity of Untransformed Mouse Cell Lines&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn3"&gt;3&lt;/xref&gt;
Authors: Robert S. Wells, Evelyn W. Campbell, Douglas E. Swartzendruber, Lawrence M. Holland, Paul M. Kraemer
 7
Journal: JNCI Journal of the National Cancer Institute (1982)

Cultured mouse cells were tested for tumorigenicity in nude mice with both a conventional assay (injection of cell suspensions) and a new test involving implantation of cells grown on gelatin sponges. Sublines of Balb/3T3 cells, obtained from different sources, varied in their tumorigenic potential with either assay. One subline (A) formed distinctive precancerous nodules only in the sponge assay; these nodules often became progressive after a latent period of 3–4 months. However, suspensions of cells of this subline also caused tumors after a similar latent period, but no nodular phase preceded tumor formation. Another subline of Balb/3T3 (M) has failed to form tumors in either assay. The Balb/3T3 sublines did not differ in in vitro properties, such as low saturation density, failure to grow in methylcellulose, and monolayer morphology. A second experimental approach involved tests on nude BALB/c mouse-embryo fibroblasts at various passage levels. The cells were passaged from primary culture, through crisis, to heteroploid, established cell lines. Tumorigenicity was demonstrable earlier in the sponge assay, at which time in vitro parameters putatively associated with malignant behavior were unchanged. Possible relationships with the in vivo phenomenon of solid-surface sarcomagenesis are discussed.
Cellular infiltrate of jejunal biopsies in adult coeliac disease in relation to gluten withdrawal
Authors: G. K. T. Holmes, P. Asquith, P. L. Stokes, W. T. Cooke
Journal: Gut (1974)

A comparison has been made of inflammatory cell counts in the lamina propria and epithelium of jejunal biopsies in 11 patients with adult coeliac disease with those found in 12 control subjects. In the coeliac patients, there were significant increases in the numbers of total cells, plasma cells, and intraepithelial lymphocytes, but a significant reduction in lamina propria lymphocytes. Following clinical improvement on a strict gluten-free diet, significant changes in cell counts occurred, but with the exception of lymphocytes in the lamina propria, the counts were still abnormal. Analysis of five patients in whom the biopsy improved to near normal morphology and of six in whom there was no such improvement showed that significant falls in plasma cells and rises in lymphocytes in the lamina propria could occur without improvement in other morphological appearances. These results seem relevant to the problem of diagnosing coeliac disease in patients who, on gluten withdrawal, show an unequivocal clinical response, but no gross morphological improvement in the jejunal biopsy. On the basis of the observed changes in cell counts, there seems little justification in questioning the diagnosis of coeliac disease in such patients.
The Human Problems of an Industrial Civilization
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recurrent Thyrotoxicosis after Subtotal Thyroidectomy
Authors: A. J. Hedley, I. P. Ross, J. S. Beck, D. Donald, F. Albert-Recht, W. Michie, J. Crooks
Journal: BMJ (1971)

A study of patients with recurrent thyrotoxicosis after subtotal thyroidectomy has shown that the operation has a profound effect on the natural history of Graves9s disease. It is followed by pronounced changes in the immunological features of the disease, with a fall in the prevalence of serum thyroid autoantibodies, including the long-acting thyroid stimulator. Thyroid suppression returns to normal in 70% of patients. The treatment produces two populations of patients. In the larger group there is a permanent remission of the disease process. In the smaller group the disease process persists and, consequently, recurrent hyperthyroidism may develop. The mechanism of the change in the larger group of patients probably has an immunological basis.
Antagonism of the Antihypertensive Action of Guanethidine Sulfate by Desipramine Hydrochloride
Authors: Jerry R. Mitchell
Journal: JAMA (1967)

In five studies, the antihypertensive effect of guanethidine sulfate was significantly reversed by two antidepressants, desipramine hydrochloride and protriptyline hydrochloride. This reversal was not immediate, requiring many hours before maximum antagonism was seen. After discontinuation of desipramine, an average of five days was required for the antihypertensive action of guanethidine to reappear. Three similar studies demonstrated that the antihypertensive action of bethanidine sulfate, a guanethidine-related drug, was reversed by desipramine also. The reversal of bethanidine was more rapid than with guanethidine, with almost maximum antagonism appearing within four hours, while the delay in the reappearance of bethanidine's antihypertensive action was similar to that seen with guanethidine. A blockade by the antidepressants of the uptake of the antihypertensives to their active site within the sympathetic neuron is suggested as a mechanism for the antagonism.
Expanding the Emergency Department
Authors: J. Cuthbert Owens
Journal: JAMA (1968)

It is agreed that, if one individual requests emergency care from an emergency department, it can accept such a patient and provide good medical care with its normal personnel and facilities. The department can probably handle five emergencies at once. However, if there are ten injured patients, offduty employees must be called in and the medical staff must be augmented. If the number of injured increases to 50, additional supplies must be obtained, additional space must be assigned for initial triage and immediate care, current hospital patients must be evacuated, all off-duty personnel must be called in, and all physicians, regardless of their field of practice, must participate. As the number of patients increases, more and more ancillary workers must be activated, but the objective should remain the same, to give every patient early, adequate, and definitive care. Finally, however, a point is reached when this objective is no longer
The ISOLDE trial
Authors: B. J Lipworth, D. Jeffries, G. K Crompton
Journal: BMJ (2000)

Investigating allegations of research misconduct Worst outcome of Griffiths report would be that research becomes increasingly difficultEditor-The Griffiths report contained a critique of two specific research projects and proposals on the regulation of research generally.Hey and Chalmers express no view on these proposals. 1However, the accompanying editorial by Smith agrees with the report's main recommendations on the need for better research governance in the NHS without citing supporting evidence.The Griffiths report made three main recommendations which could inhibit clinical research.Firstly, concern about consent for research at times of stress.Most intensive care research requires consent at times of stress and if the researchers waited this research would be impossible.The financial cost of the suggested consent from a third party would inhibit research.Secondly, the inquiry stated that brain damage could not be reliably assessed at a short period of follow up and was critical that follow up was determined by the amount of funding available.To place a requirement that all research in children involves long term follow up studies would abolish much research.The resources required are not addressed.Thirdly, trusts should ensure that arrangements are in place for active monitoring of the progress of research.There is no indication that new funding will be available for this.Furthermore, "research involving vulnerable groups should be subject to an even greater degree of independent supervision than clinical research in general."Not for the first time will there be the paradox of well-meaning discrimination against children.This has been the case for trials of new drugs, in which the perceived obstacles deter research in children. 2 The Department of Health's draft research governance "to protect participants, improve quality and stop research fraud" gives no evidence of the magnitude of these problems and does not discuss the resource implications of implementation. 3"There are already powerful incentives to adhere to many of the principles" in the framework, including the law, duty of care, and high professional standards of researchers.No evidence is quoted to assess how often these safeguards fail.Unreferenced "recent enquiries into adverse incidents relating to research" are inadequate justification.Patients must be protected from inappropriate research, and informed consent must be obtained.However, extrapolating from the Griffiths report to clinical research throughout the United Kingdom must be thought through.Currently, 40% of drugs prescribed for children are not licensed, 4 partly because of the existing deterrents to research in children.More hurdles are likely to inhibit research further, 5 and ultimately it is children particularly who will suffer.
Current Medical Literature
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fellowships, Grants, Awards
Journal: JNCI Journal of the National Cancer Institute (1992)

Fellowships, Grants, Awards Get access JNCI: Journal of the National Cancer Institute, Volume 84, Issue 14, 15 July 1992, Pages 1131–1132, https://doi.org/10.1093/jnci/84.14.1131 Published: 15 July 1992
Advertisements for donepezil
Authors: T. Greenhalgh, K. Stein, R. Milne, L. Best, H Boothby, S M N Zaidi, V Seth, S Khalaf, H Jameel, S Mahomed, A. Yassiri, P Hooper, A M Whitehead, R. W Jones, J. B Mann, S. A Saunders
Journal: BMJ (1997)