In This Issue
Journal: Cancer Discovery (2022)

In This Issue| November 02 2022 In This Issue Author & Article Information Online ISSN: 2159-8290 Print ISSN: 2159-8274 ©2022 American Association for Cancer Research2022American Association for Cancer Research Cancer Discov (2022) 12 (11): 2483–2485. https://doi.org/10.1158/2159-8290.CD-12-11-ITI Related Content A commentary has been published: Developmental Deconvolution for Classification of Cancer Origin A commentary has been published: Proteogenomic Markers of Chemotherapy Resistance and Response in Triple-Negative Breast Cancer A commentary has been published: Genetic Ancestry Correlates with Somatic Differences in a Real-World Clinical Cancer Sequencing Cohort View more A commentary has been published: Spatial Positioning and Matrix Programs of Cancer-Associated Fibroblasts Promote T-cell Exclusion in Human Lung Tumors A commentary has been published: The Single-Cell Immunogenomic Landscape of B and Plasma Cells in Early-Stage Lung Adenocarcinoma A commentary has been published: African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent A commentary has been published: AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer A commentary has been published: Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia A commentary has been published: Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia View less Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record November 2 2022 Citation In This Issue. Cancer Discov 1 November 2022; 12 (11): 2483–2485. https://doi.org/10.1158/2159-8290.CD-12-11-ITI Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search The incidence and mortality of triple-negative breast cancer (TNBC) are significantly higher in women of sub-Saharan African descent, with previous evaluations of racial differences being heavily reliant on self-reported race in U.S. populations. Martini and colleagues performed RNA sequencing of an international cohort of African Americans and West and East Africans, resulting in the identification of 613 genes associated with African ancestry and >2,000 genes connected to regional African ancestry. Differences in normal breast tissue were observed in a portion of African-associated genes, and distinct immunologic patterns in patients of African descent were detected. Together, these results may explain differential clinical outcomes between race groups. See article, p. 2530. Genetic ancestry is an important biological determinant of cancer health disparities. Arora and colleagues show that, although typically inferred using genome-wide markers, genetic ancestry can be reliably inferred from clinical cancer gene panel sequencing data, in which a pan-cancer cohort... You do not currently have access to this content.