tbuckley/cabot-search huggingface dataset:
Drug survival of metformin in patients with hidradenitis suppurativa
Authors: Marina Senent-Valero, Alicia Matijasevich, Noelia Jara-Rico, Francisca Sivera, José C Pascual
Journal: British Journal of Dermatology (2023)

Despite there being published studies on the survival of oral retinoids and biological drugs in people with hidradenitis suppurativa (HS), there is little scientific evidence on the use of metformin in this setting. We conducted a single-centre, retrospective cohort study in Spain, between January 2015 and December 2021 to determine the drug survival of metformin at 12 months in people with HS in a real-world setting. We concluded that drug survival of metformin is relatively long: half the patients were still on the drug after 1 year of treatment and one in five patients were still on the drug after 2 years.
Assessment of treatment response on facial vitiligo, a step forward. But what about the neck?
Authors: Viktoria Eleftheriadou, Julien Seneschal
Journal: British Journal of Dermatology (2023)

Journal Article Corrected proof Assessment of treatment response on facial vitiligo, a step forward. But what about the neck? Get access Viktoria Eleftheriadou, Viktoria Eleftheriadou Conceptualization, Visualization, Writing - original draft, Writing - review & editing Department of Dermatology, New Cross Hospital, Royal Wolverhampton NHS Trust, Wolverhampton, UK Correspondence: Viktoria Eleftheriadou. Email: viktoria.eleftheriadou@nhs.net Search for other works by this author on: Oxford Academic Google Scholar Julien Seneschal Julien Seneschal Conceptualization, Visualization, Writing - original draft, Writing - review & editing Department of Dermatology, Hôpital Saint-André, CHU de Bordeaux, Bordeaux, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, ljad366, https://doi.org/10.1093/bjd/ljad366 Published: 26 September 2023 Article history Received: 18 September 2023 Accepted: 20 September 2023 Published: 26 September 2023 Corrected and typeset: 02 November 2023
Genital and Perigenital “W”-Shaped Telangiectasias in Women With Limited Cutaneous Systemic Sclerosis
Authors: Nicole Dib, Camille Isnard, Luc Mouthon, Nicolas Dupin
Journal: JAMA Dermatology (2023)

This case report describes 3 patients with limited cutaneous systemic sclerosis who were found to have telangiectasias affecting the vulva and the inguinal folds.
Case 30-2023: A 50-Year-Old Woman with Confusion
Authors: Amulya Nagarur, Theodore T. Pierce, Andrew Z. Fenves, Elan R. Witkowski, Nina B. Gold
Journal: New England Journal of Medicine (2023)

A 50-year-old woman with a history of Roux-en-Y gastric bypass presented with confusion. She had anasarca and an albumin level of 1.9 g per deciliter (reference range, 3.3 to 5.0). A diagnosis was made.
4.5 Billion People Lack Coverage for Essential Health Services
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reappraisal of optimal reconstruction after distal gastrectomy – a study based on the KLASS-07 database
Authors: Shin-Hoo Park, Hoon Hur, Jong-Hyun Park, Chang-Min Lee, Young-Gil Son, Mi Ran Jung, Han Hong Lee, Sun-Hwi Hwang, Moon-Soo Lee, Sang Hyuk Seo, In Ho Jeong, Myoung Won Son, Chang Hyun Kim, Moon-Won Yoo, Sung Jin Oh, Seong Ho Hwang, Sung Il Choi, Hyuk Soon Choi, Bo-Ra Keum, Kyung Sook Yang, Sungsoo Park
Journal: International Journal of Surgery (2023)

This study aimed to compare the incidence of bile reflux, quality of life (QoL), and nutritional status among Billroth II (BII), Billroth II with Braun anastomosis (BII-B), and Roux-en-Y (RY) reconstruction after laparoscopic distal gastrectomy (LDG).
Multiple Itchy Erythematous Papules and Plaques Localized to 1 Shin
Authors: Yi-Han Chang, Chao-Kai Hsu, Wei-Ting Tu
Journal: JAMA Dermatology (2023)

A woman in her 30s presented with progressive, multiple itchy erythematous to violaceous papules and plaques with milia and a few erosions with partially detached epidermis localized to the left shin. What is your diagnosis?
Electrical impedance spectroscopy detects skin barrier dysfunction in childhood atopic dermatitis
Authors: Mari Sasaki, Mathilda Sundberg, Remo Frei, Ruth Ferstl, Kristina N. Heye, Erik P. Willems, Cezmi A. Akdis, Roger Lauener, Caroline Roduit
Journal: Allergy (2023)

Abstract Background Skin barrier dysfunction is associated with the development of atopic dermatitis (AD), however methods to assess skin barrier function are limited. We investigated the use of electrical impedance spectroscopy (EIS) to detect skin barrier dysfunction in children with AD of the CARE (Childhood AlleRgy, nutrition, and Environment) cohort. Methods EIS measurements taken at multiple time points from 4 months to 3‐year‐old children, who developed AD ( n = 66) and those who did not ( n = 49) were investigated. Using only the EIS measurement and the AD status, we developed a machine learning algorithm that produces a score (EIS/AD score) which reflects the probability that a given measurement is from a child with active AD. We investigated the diagnostic ability of this score and its association with clinical characteristics and age. Results Based on the EIS/AD score, the EIS algorithm was able to clearly discriminate between healthy skin and clinically unaffected skin of children with active AD (area under the curve 0.92, 95% CI 0.85–0.99). It was also able to detect a difference between healthy skin and AD skin when the child did not have active AD. There was no clear association between the EIS/AD score and the severity of AD or sensitisation to the tested allergens. The performance of the algorithm was not affected by age. Conclusions This study shows that EIS can detect skin barrier dysfunction and differentiate skin of children with AD from healthy skin and suggests that EIS may have the ability to predict future AD development.
One-Year Association of Drug Possession Law Change With Fatal Drug Overdose in Oregon and Washington
Authors: Spruha Joshi, Bianca D. Rivera, Magdalena Cerdá, Gery P. Guy, Andrea Strahan, Haven Wheelock, Corey S. Davis
Journal: JAMA Psychiatry (2023)

Importance Two states modified laws to remove or substantially reduce criminal penalties for any drug possession. The hypothesis was that removing criminal penalties for drug possession may reduce fatal drug overdoses due to reduced incarceration and increased calls for help at the scene of an overdose. Objective To evaluate whether decriminalization of drug possession in Oregon and Washington was associated with changes in either direction in fatal drug overdose rates. Design, Setting, and Participants This cohort study used a synthetic control method approach to examine whether there were changes in drug possession laws and fatal drug overdose rates in Oregon and Washington in the postpolicy period (February 1, 2021, to March 31, 2022, in Oregon and March 1, 2021, to March 31, 2022, in Washington). A counterfactual comparison group (synthetic controls) was created for Oregon and Washington, using 48 states and the District of Columbia, that did not implement similar policies during the study period (January 1, 2018, to March 31, 2022). For 2018-2021, final multiple cause-of-death data from the National Vital Statistics System (NVSS) were used. For 2022, provisional NVSS data were used. Drug overdose deaths were identified using International Statistical Classification of Diseases and Related Health Problems, 10th Revision underlying cause-of-death codes X40-X44, X60-X64, X85, and Y10-Y14. Exposures In Oregon, Measure 110 went into effect on February 1, 2021. In Washington, the Washington Supreme Court decision in State v Blake occurred on February 25, 2021. Main Outcome Monthly fatal drug overdose rates. Results Following the implementation of Measure 110, absolute monthly rate differences between Oregon and its synthetic control were not statistically significant (probability = 0.26). The average rate difference post Measure 110 was 0.268 fatal drug overdoses per 100 000 state population. Following the implementation of the policy change in Washington, the absolute monthly rate differences between Washington and synthetic Washington were not statistically significant (probability = 0.06). The average rate difference post Blake was 0.112 fatal drug overdoses per 100 000 state population. Conclusions and Relevance This study found no evidence of an association between legal changes that removed or substantially reduced criminal penalties for drug possession in Oregon and Washington and fatal drug overdose rates. Additional research could examine potential other outcomes as well as longer-term associations with fatal drug overdose overall and across racial and ethnic groups.
Most People With GERD Don’t Have Increased Esophageal Cancer Risk
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgical Instant Replay—A National Video-Based Performance Assessment Toolbox
Authors: Steven Yule, Joseph A. Dearani, Carla Pugh
Journal: JAMA Surgery (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Correction: Influence of socio-economic status on functional recovery after ARDS caused by SARS-CoV-2: the multicentre, observational RECOVIDS study
Authors: Pierre-Louis Declercq, Isabelle Fournel, Matthieu Demeyere, Anissa Berraies, Eléa Ksiazek, Martine Nyunga, Cédric Daubin, Alexandre Ampere, Bertrand Sauneuf, Julio Badie, Agathe Delbove, Saad Nseir, Elise Artaud-Macari, Vanessa Bironneau, Michel Ramakers, Julien Maizel, Arnaud-Felix Miailhe, Béatrice Lacombe, Nicolas Delberghe, Walid Oulehri, Hugues Georges, Xavier Tchenio, Caroline Clarot, Elise Redureau, Gaël Bourdin, Laura Federici, Mélanie Adda, David Schnell, Mehdi Bousta, Charlotte Salmon-Gandonnière, Thierry Vanderlinden, Gaëtan Plantefeve, David Delacour, Cyrille Delpierre, Gurvan Le Bouar, Nicholas Sedillot, Gaëtan Beduneau, Antoine Rivière, Nicolas Meunier-Beillard, Stéphanie Gélinotte, Jean-Philippe Rigaud, Marie Labruyère, Marjolaine Georges, Christine Binquet, Jean-Pierre Quenot, Mélody De Jesus, Sébastien Normant, Jean-Nicolas Dacher, Thomas Stoup, Christophe Vinsonneau, Anne Dewatine, Pierre Cuchet, Delphine Rots, Julien Calus, Gabriel Le Moel, Pierre Kalfon, Gaëtan Badre, Jean-François Roy, Damien Roux, Jean-Damien Ricard, Marie Marcq, Thomas Georges, Caroline Pouplet, Laurie Lagache, Nicolas Masson, Matthieu Devos, Raphaël Favory, Sébastien Preau, Alexandre Gaudet, Pierre Bouju, Lidia Nichita, Pascal Maignan, Laurence Labourot, Francesco Molinari, Laurence Thirard, Charlotte Larrat, Fernando Berdaguer, Meltem Karakaya Akgun, Yannick Fedun, Thiphaine Guy, Marie Gousseff, Déborah Boyer, Tristan Bonnevie, Elsa Demarest, Sami Hraiech, Aude Sylvestre, Céline Sanz, Anne Veinstein
Journal: Intensive Care Medicine (2023)
Systematic Review Finds the Most Effective Smoking Cessation Aids
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluating the Liability of Antidepressants to Induce Mania in Children and Adolescents With Depression
Authors: Krista F. Huybrechts, Mark Olfson
Journal: JAMA Psychiatry (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Creation of a decellularized vaginal matrix from healthy human vaginal tissue for potential vagina reconstruction: experimental studies
Authors: Jayson Sueters, Fangxin Xiao, Jan-Paul Roovers, Mark-Bram Bouman, Freek Groenman, Huub Maas, Judith Huirne, Theo Smit
Journal: International Journal of Surgery (2023)

Background: When a disorder causes absence of a healthy, full-size vagina, various neovaginal creation methods are available. Sometimes dilation or stretching of the vaginal cavity is sufficient, but intestinal or dermal flap tissue is generally required. However, different inherent tissue properties cause complications. Therefore, a lost body part should be replaced with a similar material. The use of organ-specific acellular vaginal tissue carries great potential, as its similar architecture and matrix composition make it suitable for vaginal regeneration. Methods: We developed an optimized protocol for decellularization of healthy, human vaginal tissue. Resected colpectomy tissue from 12 healthy transgender patients was used. Successful decellularization was confirmed by applying acellular criteria from in vivo remodeling-reports. Suitability as tissue-mimicking scaffold for vaginal reconstruction was determined by visible structural features, biocompatibility during stretching and presence of visible collagen, elastin, laminin and fibronectin. Results: Histological examination confirmed the preservation of structural features and minimal cellular residue was seen during fluorescence microscopy, DNA and RNA quantification and fragment-length examination. Biomechanical testing showed decreased peak load (55%, P &lt;0.05), strain at rupture (23%, P &lt;0.01) and ultimate tensile stress (55%, P &lt;0.05) after decellularization, while the elastic modulus (68%) did not decrease significantly. Fluorescence microscopy revealed preserved Fibronectin-I/II/III and Laminin-I/II, while Collagen-I and Ficolin-2B were decreased but mostly retained. Conclusions: The absence of cellular residue, moderately altered biomechanical extracellular matrix (ECM) properties and mostly preserved structural proteins, appear to make our decellularized human vaginal matrix a suitable tissue-mimicking scaffold for vagina transplantation when tissue survival through vascularization and innervation are accomplished in the future.
Prospective cohort study of parathyroid function and quality of life after total thyroidectomy for thyroid cancer: robotic surgery vs. open surgery
Authors: Xiangquan Qin, Jia Luo, Jing Ma, Xiaozheng Cao, Jinjin Zhao, Jun Jiang, Yi Zhang, Lingjuan Zeng, Linjun Fan
Journal: International Journal of Surgery (2023)

Objective: To compare robot-assisted thyroidectomy (RT) and open thyroidectomy (OT) through a prospective cohort study focusing on the rate of postoperative hypoparathyroidism, efficacy, and quality of life (QoL). Summary Background Data: Hypoparathyroidism is a frequent complication after thyroidectomy. Reducing the risk of hypoparathyroidism after total thyroidectomy is a crucial and difficult task for thyroid surgeons. Methods: We prospectively enrolled 306 patients with papillary thyroid carcinoma(PTC) into an RT group and OT group. The former used “super-meticulous” capsular dissection (SMCD) and the latter used traditional meticulous capsular dissection. Patients were evaluated by scales [Short Form (SF)-36, Visual Impairment Scale (VIS), Swallowing Impairment Scale (SIS), Neck Impairment Scale (NIS), Scar questionnaire (SCAR-Q)]. Results: The rates of transient hypoparathyroidism, permanent hypoparathyroidism, and transient hypocalcemia after surgery in the OT group and RT group were significantly different ( P &lt;0.001). SIS and VIS scores in the two groups were significantly different ( P &lt;0.001). SF-36 showed significant differences ( P &lt;0.001) in the subsections of “physiological function”, “body pain”, “general health”, “vitality”, “social function”, “role emotional”, and “mental health” between the two groups. SCAR-Q showed that the length and appearance of scars showed significant differences between the two groups. Conclusions: Robot-assisted thyroidectomy with Super-meticulous capsular dissection can protect parathyroid function and improve postoperative QoL, and could be a new option for robot-assisted surgery against thyroid cancer.
A commentary on ‘Surgeons’ mental distress and risks after severe complications following radical gastrectomy in China: a nationwide cross-sectional questionnaire’
Authors: Siyu Tan, Xiaotian Wu, Chenyu Wang, Shengbing Zhao
Journal: International Journal of Surgery (2023)

aThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, 730000, People's Republic of China bThe Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, 730000, People's Republic of China cThe Fifth Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu Province, 730000, People's Republic of China No data was generated during the writing of this study. Siyu Tan, Xiaotian Wu These authors contributed equally to this work. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding Author. Address: The Fifth Department of General Surgery, The First Hospital of Lanzhou University, No.1 Road, Chengguan District, Lanzhou City, Gansu Province, PR China 730000. E-mail address: [email protected] (S. Zhao). This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-nc-sa/4.0/
Transition to Schizophrenia Spectrum Disorder Following Emergency Department Visits Due to Substance Use With and Without Psychosis
Authors: Daniel T. Myran, Lyndsay D. Harrison, Michael Pugliese, Marco Solmi, Kelly K. Anderson, Jess G. Fiedorowicz, Christopher M. Perlman, Colleen Webber, Yaron Finkelstein, Peter Tanuseputro
Journal: JAMA Psychiatry (2023)

Episodes of substance-induced psychosis are associated with increased risk of developing a schizophrenia spectrum disorder. However, there are limited data on the transition risk for substance use without psychosis.