tbuckley/cabot-search huggingface dataset:
Abstract 5149: A novel regulatory circuit involving STIM1 and HIF-1 mediates hypoxia-driven hepatocarcinogenesis
Authors: Yongsheng Li
Journal: Cancer Research (2016)

Abstract Hypoxia and intracellular Ca2+ transient are fundamental traits of cancer. Signaling cascades initiated or regulated by HIF-1 is essential for hypoxic responses. Stromalinteraction molecule 1 (STIM1) is well known as a Ca2+ sensor on endoplasmic reticulum (ER) that mediates SOCE activation and promotes tumor invasion and migration. However, there was no general consensus about the relationship between HIF-1 and STIM1. Also, the significance of STIM1, as well as the Ca2+ mobilization route in cancer cells during hypoxia remains unknown. Our results show that STIM1 correlates with elevated hypoxia-inducible factor-1 alpha (HIF-1α) in hypoxic hepatocarcinoma cells (HCC) and is upregulated during hepatocarcinoma growth. HIF-1 directly transcripts STIM1 and contributes to store-operated Ca2+ entry (SOCE), while STIM1-mediated SOCE is also required for HIF-1 accumulation in hypoxic HCC, via activating Ca2+/calmodulin-dependent protein kinase II and p300. Administration of YC-1, a HIF-1 inhibitor, or knockdown of HIF1A significantly diminishes hypoxia-enhanced STIM1 and suppresses tumorigenesis. Moreover, ectopic expression of STIM1 or HIF-1α partially reverses the impaired growth of the tumor treated with YC-1. These results suggest a mutual dependency and regulation of STIM1 and HIF-1 in controlling Ca2+ mobilization and hypoxic tumor growth, and highlight a potential target for early hypoxia-related intervention. Citation Format: Yongsheng Li. A novel regulatory circuit involving STIM1 and HIF-1 mediates hypoxia-driven hepatocarcinogenesis. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 5149.
Membership Dues and Subscriptions.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Social class at birth may affect outcome in schizophrenia
Journal: BMJ (2001)

Oral iron can improve motor and language development in preschool children Oral iron supplementation improves motor and language development in iron deficient preschool children.Iron deficiency anaemia is associated with defects in child development.Stoltzfus et al (p 1389) looked at the effects of iron supplementation, anthelmintic treatment, or both in preschool children in Zanzibar, where anaemia and geohelminth infections were prevalent.Iron supplementation in children with serious iron deficiency conferred important benefits to their motor and language development, even in communities where malaria is endemic and is a major cause of anaemia.
Adducted proteins for identification of endogenous electrophiles
Authors: M Törnqvist, A Kautiainen
Journal: Environmental Health Perspectives (1993)

Chemically reactive compounds in tissues can be monitored through their products of reaction with biomacromolecules.For the purpose of in vivo dose monitoring, hemoglobin (Hb) has been preferred to DNA because of its well-defined life span and more facile chemical identification ofadducts.Through the N-alkyl Edman method, adducts to the N-terminals (valines) of the globin chains are measured mam spectrometrically with high sensitivity.In studies of low molecular weight adducts from occupational exposures or tobacco smoke, background levels were found in nonexposed control persons.In some cases the origin of these adducts could be determined.For instance, the 2-hydroxyethyl adduct has been shown to originate from ethylene oxide, a metabolite of endogenously produced ethene.The measured level, about 20 pmole/g globin, agrees well with the ethylene oxide dose calculated from expired ethene.Animal studies indicate contributions from the intestinal flora and dietary factors.An average background level of about 200 pmole/g globin of methylvaline has been observed in unexposed humans.From reaction-kinetic studies of S-adenosylmethionine (SAM), it has been shown that the background mainly originates from SAM.In twin studies, a genetic influence on the level has been shown.Further- more, a contribution from tobacco smoking to the level was demonstrated in these studies.Certain aldehydes, e.g., malonaldehyde, have been shown to be related to dietary factors and lipid peroxidation.These studies show the usefulness of the method in a search for reactive compounds in the body, with the ultinate goal of assessing the total genotoxic load. N-Alkylvalines N-(2-Hydroxyethyl)valineMeasurement.N-(2-Hydroxyethyl)valine (HOEtVal) has been extensively studied with the N-alkyl Edman method, ethylene oxide being used as a model carcinogen during method develop-
Sp1 binding activity increases in activated ito cells*1
Authors: R RIPPE
Journal: Hepatology (1995)

Ito cells are the primary cell type in the liver responsible for increased type I collagen production observed during fibrogenesis. After a fibrogenic stimulus, Ito cells change from their normal quiescent state to an activated state. In this study, we examined the expression of the α1(I) collagen gene in Ito cells that were freshly isolated from normal rat liver (quiescent) and Ito cells that were activated by culture on plastic. Northern blots showed that α1(I) collagen messenger RNA levels were low in freshly isolated Ito cells and Ito cells cultured on plastic for up to 4 days, but were induced after 7 days in culture. To determine the location of important transcriptional regulatory elements within the 5′-flanking region of the α1(I) collagen gene, transient transfections using various portions of the αl(I) collagen gene promoter linked to the luciferase gene were performed in cultured Ito cells. As in fibroblast cells, only 220 base pairs (bp) of immediate 5′-flanking sequence of the collagen α1(I) gene was necessary for efficient expression of the reporter gene. Deoxyribonuclease I footprinting analysis and mobility shift assays showed dramatic differences in the DNA binding proteins that interact with the 220 base pair promoter region of the α1(I) collagen gene between freshly isolated and activated Ito cells. Sp1 binding activity was greatly increased in activated Ito cells, as was binding activity for CCAAT binding factor (CBF), a transcription factor previously shown to interact with the α2(I) collagen gene promoter. The increased Sp1 binding activity to the α1(I) collagen gene promoter involves a posttranscriptional event, as shown by Northern and Western blots. Therefore, we show that activated Ito cells have a different pattern of transcription factor binding activity interacting with the α1(I) collagen gene promoter compared with quiescent Ito cells, including increased Sp1 binding activity, and that this may contribute to the increase in α1(I) collagen gene expression during fibrosis.
Die Ohrenheilkunde der Gegenwart und ihre Grenzgebiete.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tetanus mimicking psychophysiologic reaction. Occurrence after dental extraction
Authors: C. R. Treadway
Journal: JAMA (1967)

THE FOLLOWING CASE is presented for three reasons. First, the wound of dental extraction is a relatively rare and usually unconsidered portal of entry for the tetanus organism. Graves in 1930 reported three cases of tetanus after dental extraction.<sup>1</sup>Three years later Appleton was able to find only three additional cases reported in the literature and attributed the infection to inadequate sterilization of dental instruments.<sup>2</sup>Griswold and Herring in 1949 described a patient with tetanus following dental extraction who was initially thought to be hysterical.<sup>3</sup>Shershin and Katz in 1964 reported an additional case and gave references to two other case reports in the world literature.<sup>4</sup> Second, the symptoms of the patient's tetanus infection accurately mimicked in exaggerated form symptoms which had long been present on presumably a psychophysiologic basis. Thus, diagnosis of tetanus was delayed. Third, as part of a survey project the patient's ankle
Systemic transforming growth factor‐beta in patients with bone marrow fibrosis—pathophysiological implications
Authors: Pranela Rameshwar, Victor T. Chang, Usha F. Thacker, Pedro Gascón
Journal: American Journal of Hematology (1998)

Idiopathic myelofibrosis (IMF) and secondary myelofibrosis (MF) are characterized by bone marrow (BM) fibrosis, neoangiogenesis, and increased extracellular matrix (ECM) proteins. These characteristics may be partially attributed to transforming growth factor beta (TGF-β), a cytokine produced by monocytes. In myelofibrosis, monocytes are increased and activated with concomitant up-regulation of intracytoplasmic TGF-β. We have therefore determined systemic TGF-β in patients with either BM fibrosis: IMF, n = 18; MF, n = 16; or without BM fibrosis: hematologic disorders with normal platelets (n = 31); high platelets (n = 9); or normal controls (n = 27). Compared with nonfibrosis sera, there was significant TGF-β elevation in BM fibrosis sera (P < 0.0001). Most (>80%) of the TGF-β is active and belongs to the −β1 isoform. In situ hybridization and immunohistochemical analyses in BM biopsy sections showed a marked increase in TGF-β1 only in patients with fibrosis. Moreover, TGF-β protein was detected mainly in myelomonocytic-like predominant areas. To determine if another functionally similar cytokine, basic fibroblast growth factor (bFGF), may be important to BM fibrosis, we quantitated sera levels and found elevation in 57% compared with 100% elevation for TGF-β. The data indicate that irrespective of etiology, systemic TGF-β is elevated in patients with BM fibrosis. TGF-β likely plays an important role in the development of BM fibrosis. The study also provides a significant parameter for early therapeutic intervention in BM fibrosis. Am. J. Hematol. 59:133–142, 1998. © 1998 Wiley-Liss, Inc.
Inherited primary peripheral neuropathies. Molecular genetics and clinical implications of CMT1A and HNPP
Authors: J. R. Lupski
Journal: JAMA (1993)

CHARCOT-MARIE-TOOTH disease type 1A (CMT1A) and hereditary neuropathy with liability to pressure palsies (HNPP) are autosomal dominant, inherited primary demyelinating peripheral neuropathies that appear to result from reciprocal DNA duplication/deletion, respectively, of a 1.5-megabase (Mb) pair region on chromosome 17p. While inherited DNA rearrangements are present in most CMT1A and HNPP patients, new mutation duplication or deletion can be responsible for sporadic cases of CMT1A or HNPP. This critical 1.5-Mb region is likely to contain multiple genes, but a dosage effect of one gene that encodes a myelin protein of the peripheral nerve (<i>PMP22</i>) appears to play a critical role in the disease phenotype. Moreover,<i>PMP22</i>point mutations associated with CMT1A have been identified in patients who do not have the<i>CMT1A</i>duplication. The recent elucidation of the molecular mechanisms for CMT1A and HNPP has important clinical implications for the diagnosis, prognosis, genetic counseling, and rational approaches to therapy for
Highlights
Journal: JAMA (2016)

Evolocumab and Coronary Disease in Statin-Treated Patients 2373Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors produce incremental lowering of low-density lipoprotein cholesterol in statin-treated patients.In a randomized placebo-controlled clinical trial that enrolled 968 patients with angiographic coronary disease treated with statins, Nicholls and colleagues assessed the eff ect of PCSK9 inhibition with evolocumab-added to statin therapy-on progression of coronary atherosclerosis.The authors report that compared with statin therapy alone, evolocumab combined with statin therapy resulted in a greater decrease in percent atheroma volume. CME jamanetworkcme.com County-Level Trends in Mortality for Major Causes of Death 2385In analyses of US vital statistics data representing more than 80 million deaths from 1980 through 2014, Dwyer-Lindgren and colleagues assessed county-level patterns in mortality rates for 21 major causes of death.The authors found large between-county disparities for all 21 causes of death.Geographic regions with elevated mortality rates diff ered among causes.For most causes of death, both increases and decreases in county-level mortality rates were observed from 1980 through 2014.In an Editorial, Clark and Williams discuss the limitations and potential contributions of small area modeling approaches to inform priorities and design strategies to address geographic health disparities.
Blood Lead and Blood Pressure: Some Implications for the Situation in the Netherlands
Authors: Wim L. A. M. de Kort, Wim C. M. Zwennis
Journal: Environmental Health Perspectives (1988)

Studies performed earlier have shown a positive relation between blood lead (a parameter for lead body burden) and blood pressure, whereas such a relation between urine cadmium (a parameter for cadmium body burden) and blood pressure could not be shown. Median (i.e., 50th percentile, P50) blood levels in the general population in the Netherlands are in the range of 80 to 150 micrograms/L. Persons occupationally exposed to lead show median blood lead levels that may exceed 400 micrograms/L. To study causality, a prospective study among lead workers is desired.
Legionnaires' Disease Associated With Cooling Towers—Massachusetts, Michigan, and Rhode Island, 1993
Journal: JAMA (1994)

From July through October 1993, outbreaks of Legionnaires' disease (LD) were reported from communities in Massachusetts and Rhode Island and from a state prison in Michigan. Cooling towers (CTs) were identified as the source of all three outbreaks. This report summarizes investigations by state and local health officials and CDC and efforts to control these outbreaks.
Thyroid nodularity in children
Authors: M. L. Rallison
Journal: JAMA (1975)

Of 5,179 school children surveyed in Utah, Nevada, and Arizona for thyroid abnormalities because of possible exposure to radiation from fallout, nodularity of the thyroid was found in 93 (1.8%). In 34, the nodularity represented lobulation associated with adolescent goiter, and in 31, thyroiditis. Two malignant neoplasms were found. In a normal childhood population in which nodularity is incidentally discovered on physical examination, the risk of nodularity being malignant is approximately 2%. Factors that favor exploration of thyroid nodules in children are discreteness, growth of the mass, singleness, and absence of other thyroid disease. (<i>JAMA</i>233:1069-1072, 1975)
Catheter ablation improved quality of life more than drug therapy at 1 y in symptomatic atrial fibrillation
Authors: Gaetano Santulli
Journal: Annals of Internal Medicine (2019)

Source Citation Blomström-Lundqvist C, Gizurarson S, Schwieler J, et al. Effect of catheter ablation vs antiarrhythmic medication on quality of life in patients with atrial fibrillation: the CAPTAF randomized clinical trial. JAMA. 2019;321:1059-68. 30874754
Correction: ABC of Alcohol: Help: Referral
Journal: BMJ (1982)

Cimetidine, although effective in relieving dyspeptic symptoms, may not protect against perforation.'We report on two patients with perforated peptic ulcers who were treated with cimetidine for duodenal ulceration.Caution must be exercised while con- tinuing treatment with non-steroidal anti-inflammatory drugs for rheumatic disorders.
UNIFORM STATE LEGISLATION.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Patients with alcoholic hepatitis present strong Th1 cellular immune responses to alcohol dehydrogenase related to impairment of the PD-1/PD-L1 pathway due to high circulating levels of soluble PD-1
Authors: Laura Blackmore, Brandon Turner, Xiaohong Huang, Munther Hussain, Debbie L. Shawcross, Yun MA
Journal: Journal of Hepatology (2020)
APPROVED RESIDENCIES AND FELLOWSHIPS
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mesenteric Arteritis in Systemic Lupus Erythematosus
Authors: Jerry C. Phillips
Journal: JAMA (1968)

Mesenteric arteriography was performed in a patient who had systemic lupus erythematosus with active intestinal bleeding. The arteriogram demonstrated not only the site of the bleeding, but also diffuse irregularities of the small intestinal arteries. This diffuse irregularity of small vessels correlates well with the pathologic description of diffuse mesenteric arteritis characteristically occurring in this disease entity. Mesenteric arteriography is suggested as the initial diagnostic procedure in patients with collagen disease and who exhibit active, lower-intestinal bleeding.
Ivosidenib Deemed Safe, Effective in AML
Journal: Cancer Discovery (2018)

A phase I study suggests that ivosidenib can induce remission in patients with relapsed or refractory acute myeloid leukemia characterized by IDH1 mutations. The drug spurred complete remission or complete remission with partial hematologic recovery in 30.4% of patients. The most common side effects of at least grade 3 were prolonged QT interval and IDH differentiation syndrome.