tbuckley/cabot-search huggingface dataset:
Abstract 3607: Plasma ω-3 polyunsaturated fatty acids associated with reduced risk of heart failure among women: the Atherosclerosis Risk In Communities (ARIC) Study
Authors: Kazumasa Yamagishi, Jennifer A Nettleton, Aaron R Folsom
Journal: Circulation (2007)

BACKGROUND A previous prospective study showed that dietary intakes of fish or ω-3 polyunsaturated fatty acids (PUFA) were associated with reduced risk of heart failure (HF), but no study has examined the association between plasma ω-3 PUFA and HF. Our a priori hypothesis was that plasma ω-3 PUFA would be inversely associated with incident HF. METHODS We included 3,592 white participants from the Minneapolis field center of the ARIC Study, aged 45– 64 at baseline (1987– 89), initially free of coronary heart disease, stroke and HF. Fractions of plasma cholesterol ester (CE) and phospholipid (PL) ω-3 PUFA of marine origin (eicosapentaenoic acid [EPA], ω-3 docosapentaenoic acid [DPA] and docosahexaenoic acid [DHA]) were measured by gas-liquid chromatography. The subjects were followed through 2003, and incident HF was defined by a hospital discharge or death including a HF ICD code. The hazard ratio and 95% confidence interval (HR [95%CI]) for HF was calculated according to quintiles of CE and PL fractions of ω-3 PUFA. RESULTS During the 14.3-year follow-up, we identified 197 cases of CHF (110 for men and 87 for women). After adjustment for age and potential risk factors (smoking, pack-years, alcohol consumption, body mass index, systolic blood pressure, antihypertensive medication use, plasma total cholesterol, diabetes and total energy intake), the incidence of HF for women was associated inversely and linearly with ω-3 PUFA in the PL fraction (HR for highest quintile vs lowest quintile was 0.27 [0.12– 0.63], p for trend &lt;0.001). There was a similar tendency for the CE fraction for women (HR=0.45 [0.20 –1.03], p for trend =0.08). No associations were observed for men (interaction for gender p=0.04 for PL fraction). CONCLUSIONS We found a significant inverse association between plasma ω-3 PUFA and incident HF among women, consistent with a prior study using a food frequency questionnaire. Contrary to our hypothesis, however, no such association was observed for men.
Abstract P409: Both Body Mass Index and Waist Circumference are Adversely Associated with Exposure to Trans-fatty Acids in Persons with Type 2 Diabetes
Authors: Dawn Schwenke, John Foreyt, Edgar Miller, Rebecca Reeves, Mara Vitolins, I Oxidative Stress Subgroup of Look AHEAD
Journal: Circulation (2013)

Trans-fatty acids (TFA) increase cardiovascular disease risk and have been associated with the cardiovascular risk factors body mass index (BMI) and waist circumference (waist) in persons without diabetes. Whether TFA are associated with BMI and waist in persons with type 2 diabetes is unknown. We investigated the association between TFA exposure as indicated by plasma concentrations of 18-carbon TFA and BMI and waist. We studied persons randomized into Look AHEAD at two clinics (Baltimore, n=81; Houston, n=151) who participated in a substudy assessing physical activity and an ancillary study of oxidative stress and completed the Look AHEAD Food Frequency Questionnaire (LAFFQ). Look AHEAD is a multi-center controlled trial of lifestyle intervention for weight loss in overweight or obese adults (aged 45-76) with type 2 diabetes. Representation of women (57%) and minorities (18.1% black, 8.2% Hispanic, 3.9 % other race/ethnicity) was similar to Look AHEAD. Before intervention, weight, height, and waist were measured, BMI was calculated, nutrients were estimated from LAFFQ, and physical activity was determined by accelerometry. TFA, saturated (SFA) and cis-monounsaturated (c-MFA) fatty acids were measured before intervention in plasma collected between December 2002 and April 2004. TFA intake in subjects was high (median 2.4% of energy, interquartile range 1.9%, 3.0%). In models adjusted for age, sex, race/ethnicity, clinic, sampling time, physical activity, and plasma total fatty acid concentration, BMI (p=0.0004) and waist (p=0.0018) varied according to plasma TFA concentration. For lowest, middle, and highest tertiles of plasma TFA, BMI was (mean+SE) 33.0+0.9, 36.9+0.9, and 36.6+0.9 kg/m 2 , respectively, while waist was 108.4+1.9, 115.8+1.9, and 114.8+2.0 cm, respectively. These associations were not attenuated by sequential adjustment for plasma SFA and c-MFA concentrations and for dietary variables including TFA, total fat, SFA, oleic acid, protein and total calories. These results extend findings concerning TFA exposure and BMI and waist circumference to persons with type 2 diabetes and are consistent with the notion that reducing TFA exposure may reduce cardiovascular risk in persons with type 2 diabetes.
ACRODYNIA
Authors: J. B. BILDERBACK
Journal: JAMA (1925)

It is questionable whether the disease that American writers are calling acrodynia is the same as the one which occurred in epidemic form in France in the year 1827, and within two years had attacked between forty and fifty thousand people. The term acrodynia (derived from two Greek words, meaning extremity and pain) was first given by Chardon in 1830 to this epidemic disease. Acrodynia, or epidemic erythema, is a disease largely affecting adults and is characterized by an erythematous dermatitis especially affecting the palms and soles and followed by pigmentation. It is also followed by vomiting and diarrhea and frequently by cramps and spasms of the muscles, sometimes by paralysis of the legs and general anasarca. It generally runs a course of from two to four weeks, and recurrent attacks are not uncommon. Recently, Petren,<sup>1</sup>in Sweden, pointed out the great probability of the famous acrodynia epidemic having
Highlights
Journal: JAMA Internal Medicine (2020)

Sugar-Sweetened Beverages Ban and Employee Health 9In this before-and-after study and additional randomized trial, Epel and colleagues evaluated whether a workplace ban on sugar-sweetened beverage sales was associated with sugarsweetened beverage intake and cardiometabolic health among employees and whether a brief motivational intervention provided added benefits to the sales ban.The employer in the trial stopped selling sugar-sweetened beverages in all workplace venues, and half of the participants were randomized to receive a brief motivational intervention.Participants reported consuming fewer sugar-sweetened beverages after the ban as well as a reduction in waist circumference and sagittal diameter but no change in body mass index or insulin sensitivity.Those randomized to receive a brief motivational intervention reported greater improvements.
ANKYLOSTOMIASIS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predicting survival in fulminant hepatic failure using serum gc protein concentrations
Authors: William M. Lee, Robert M. Galbraith, Graeme H. Watt, Robin D. Hughes, Donald D. McIntire, Brenda J. Hoffman, Roger Williams
Journal: Hepatology (1995)

Plasma Gc protein sequesters actin released into the circulation after massive hepatocyte necrosis, but is greatly depleted in the process. In fulminant hepatic failure (FHF), Gc is present in serum both as a complex with actin and as unbound protein, the latter becoming completely exhausted in those patients with the most severe FHF. In the present study, 47 consecutive patients with FHF, 39 of whom were the result of acetaminophen (AC) overdose, were evaluated to determine whether measurement of Gc protein levels could be used to predict survival. Using serum samples obtained shortly after admission as well as later samples, levels for total Gc protein, percentage of Gc complexed with actin, and calculated unbound Gc remaining in serum were compared for survivors and those who died of their illness. The most marked changes were present in unbound Gc levels in nonsurvivors, the mean of which for follow-up samples was 10% of normal mean values, as compared with 23% of normal mean values in those who survived ( P &lt;.01). Using a cutoff value for unbound Gc protein of ±34 μg/mL to predict survival, outcome was correctly predicted in 32 of 47 (68%) patients using early samples, and in 24 of 27 (89%) patients using later sera. No differences were observed between values and/or outcome in AC and non-AC cases. Measurement of Gc protein level correctly predicted all patients dying of hepatic failure. This single measurement compares favorably with multifactorial predictive models, such as the King's College model, and might be a useful test for patients being considered for transplantation. (Hepathology 1995;21:101-105).
Signs
Authors: Rae Varcoe
Journal: Annals of Internal Medicine (2005)

Ad Libitum3 May 2005SignsRae Varcoe, MA, MB, ChB, FRACP, FRCPARae Varcoe, MA, MB, ChB, FRACP, FRCPAFrom Auckland Hospital, Auckland 1, New Zealand.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-9-200505030-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Rae Varcoe of Auckland, New Zealand, is the winner of Annals of Internal Medicine's 2004 Poetry Prize. The poet actually took both first and second places for her poems “Signs” and “Ode to My Right Hand,” respectively. “Signs” was published in the 5 October 2004 issue of Annals (vol. 141, no. 7) and is reprinted here. Annals extends thanks to the contest judges, Daniel Bosch, John Stone, and Abigail Zugar. Daniel Bosch's latest book of poetry is Crucible, published by Handsel Books. John Stone's latest book of poetry is Music From Apartment 8: New and Selected Poems, published by Louisiana ... Author, Article, and Disclosure InformationAffiliations: From Auckland Hospital, Auckland 1, New Zealand.Current Author Address: Rae Varcoe, MA, MB, ChB, FRACP, FRCPA, Auckland Hospital, Park Road, Private Bag 92024, Auckland 1, New Zealand. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 May 2005Volume 142, Issue 9Page: 792 ePublished: 3 May 2005 Issue Published: 3 May 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Misplaced Line
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE FORTIETH ANNUAL MEETING OF THE AMERICAN MEDICAL ASSOCIATION.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ASSOCIATION OF THE MILITARY SURGEONS OF THE UNITED STATES.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
UICC Advanced Course on Clinical Cancer Chemotherapy
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article UICC Advanced Course on Clinical Cancer Chemotherapy Get access JNCI: Journal of the National Cancer Institute, Volume 70, Issue 4, April 1983, Page 787, https://doi.org/10.1093/jnci/70.4.787 Published: 01 April 1983
1245 TOXIC LIPIDS STORED BY KUPFFER CELLS CORRELATES WITH THEIR PRO-INFLAMMATORY PHENOTYPE AT AN EARLY STAGE OF STEATOHEPATITIS
Authors: A. Leroux, V. Godié, F. Cailleux, S. Naveau, S. Prévot, S. Makhzami, G. Perlemuter, A.M. Cassard-Doulcier
Journal: Journal of Hepatology (2012)
PWE-132 Enhanced expression of secretory phospholipase A2 and cryptdins in small intestinal paneth cells following<i>Trichinella spiralis</i>infection
Authors: W S Wan Shahida, R J Morgan-Walsh, Y R Mahida
Journal: Gut (2012)

<h3>Introduction</h3> <i>T spiralis</i> infection leads to a T cell-dependent enteropathy characterised by villus atrophy, crypt hyperplasia and an increase in Paneth and goblet cells. Paneth cells express a number of antimicrobial peptides and proteins. Our aim was to investigate changes in the expression of cationic antimicrobial peptides and proteins that are normally expressed by Paneth cells. <h3>Methods</h3> Small intestinal epithelial cells were isolated from control mice and those infected with <i>T spiralis</i>. Concentrated cell extracts (in acetic acid) were studied by acid urea-polyacrylamide gel electrophoresis (AU-PAGE) and Western blot analysis. Samples with similar protein concentrations were used to assess antimicrobial activity against <i>Escherichia coli</i>, after 5 h of incubation at 37°C, using the following equation: antimicrobial activity = [(OD620 of control solution−OD620 of sample)/OD620 of control solution] ×100. <h3>Results</h3> The establishment of infection with the nematode was confirmed by the presence of worms in the small intestinal lumen, changes in mucosal architecture and increase in Paneth and goblet cell numbers. In contrast to controls, AU-PAGE analysis of Paneth cell-containing small intestinal epithelial cell extracts from <i>T spiralis</i>-infected mice showed two prominent bands. AU-PAGE-Western blot and amino acid sequence analyses identified one of these bands to be secretory phospholipase A2. Sequences for cryptdins were detected in the second prominent band. Acid extracts of epithelial cells isolated from <i>T spiralis</i>-infected mice showed significantly greater antimicrobial activity, compared to those from control mice [mean 54.7 (SEM 8.7)% vs 7.3 (3.5)%; p=0.001]. <h3>Conclusion</h3> Following <i>T spiralis</i> infection, there was an increase in small intestinal epithelial expression of secretory phospholipase A2 and cryptdins. Enhanced production of these Paneth cell-derived peptides is likely to mediate greater antimicrobial activity against luminal bacteria in <i>T spiralis</i>-infected small intestine. <h3>Competing interests</h3> None declared.
Medicolegal Application of Human Blood Grouping
Authors: Reuben Ottenberg
Journal: JAMA (1983)

Since 1907, when I did the first transfusion recorded in which tests for blood compatibility were made,<sup>1</sup>I have performed many thousand blood group tests. Occasionally I have had to correct my own errors as well as those of others. Experience with successive generations of hospital interns has taught me that, in spite of the simplicity of the test, most beginners will make mistakes in grouping unless specifically taught about certain sources of error. The subject is particularly important at present because: (1) Blood transfusion is being increasingly used; (2) the group test will probably be employed in the near future in medicolegal work, and (3) Buchanan's recent articles<sup>2</sup>denying the correctness of all the preceding work on the heredity of the blood groups make it necessary for some other person to do an extensive piece of investigation. <h3>WHAT IS THE BEST TECHNIC?</h3> A number of different methods
Will screening individuals at high risk of cardiovascular events deliver large benefits? Yes
Authors: R. Jackson, S. Wells, A. Rodgers
Journal: BMJ (2008)

The Department of Health is planning to identify and treat all adults over 40 at high risk of a cardiovascular event. <b>Rod Jackson and colleagues</b> argue that a well targeted programme will save many lives, but <b>Simon Capewell</b> (doi: 10.1136/bmj.a1395) thinks whole population approaches would be more cost effective
<i>A Case of Fracture of the Twelfth Dorsal Vertebra, followed by Injury to the Spinal and Sympathetic Nerve-Supply of the Bowel in the Region of the Ileo-Cœcal Valve; Intestinal Hœmorrhage and Death on the Seventh Day</i>. By J. T. Eskridge, M. D., Denver, Colorado. Reprinted from the<i>Medical News,</i>October 10, 1891
Authors: J. M. M.
Journal: American Journal of Psychiatry (1892)
Abstracts for the Second International Symposium on Central Nervous System Germ Cell Tumors
Authors: S Asgharzadeh, I Gonzalez-Gomez, Y Tu, F Gilles, M Krieger, J Finlay, Maria Castro, Gwendalyn King, James Curtin, Marianela Candolfi, Chunyan Liu, Kurt Kroeger, Mariana Puntel, Weidong Xiong, Pedro Lowenstein, C Lau, R Palmer, N Foster, I Roberts, K D'andrea, K Nathanson, J Nicholson, N Coleman, D Schneider, S Zahn, K Alemazkour, S Sievers, A Schuster, G Calaminus, U Göbel, E Perlman, D Keene, E Bouffet, J Brossard, A Carret, B Crooks, C Fryer, C Mpofu, A Moghrabi, I Odame, D Strouther, S Zelcer, R Silva, Hospitalario Oncopediatrico, Roha Argentino, Kaleidos Fundacion, E Schvartzman, M Scopinaro, D Alderete, P Reichel, V Welsh, M Matus, B Diez, Roha -C Buenos, J Allen, J Siffert, L Velasquez, B Donahue, S Sands, M Wharam, C Kretschmar
Journal: Neuro-Oncology (2005)

The purpose of this study is to further characterize the immunophenotype of CNS germinomas with emphasis on the expression of CD117 (c-kit) in relation to possible mutations of the c-kit gene.Biopsy material from 20 CNS germinoma cases was studied immunohistochemically.In 10 cases, archived frozen tumor tissue was available for c-kit proto-oncogene mutation analysis.DNA extracted from regions with Ͼ80% tumor density underwent whole genome amplifi cation prior to mutation analysis.In one additional case, mutation analysis was performed on paraffi n-embedded tissue.Forward and reverse sequencing were performed on c-kit's exons 9, 11, 13, and 17.The neuroanatomical distribution of tumors is as follows: 10 pineal, six suprasellar, two thalamic, one basal ganglia, and one in the posterior third ventricle.There were 15 males and fi ve females, with an age average of 13.25 years and an age range of 7 to 17 years.The immunohistochemical profi le revealed strong positive staining for PLAP and CD117 in 100% of cases.The latter was always diffuse and stronger than PLAP.This difference was more accentuated in tissue frozen for intraoperative consultation and subsequently fi xed in formalin and processed routinely.HCG showed a weak diffuse cytoplasmic staining with few scattered strongly stained cells.AFP, CEA, and CD30 were consistently negative.Staining for vimentin and keratin reveal few scattered cells showing focal cytoplasmic staining.Molecular analysis for c-kit mutations showed 1/11 tumors with exon 17 (N822Y) mutation.This mutation represents gain-of-function mutation.We conclude that CD117 is a reliable immunohistochemical marker for germinomas.No relation between immunophenotype and mutations analysis was identifi ed.The 9% c-kit mutation rate in our study is consistent with previous reports of low frequency of c-kit mutations in germinomas.
Hemodynamic monitoring in patients with acute myocardial infarction
Authors: J. S. Forrester
Journal: JAMA (1973)

Although treatment of many commonly encountered disorders has changed in the past decade, none has evolved more dramatically than that of acute myocardial infarction. Ten years ago, a new era began with arrhythmia monitoring in coronary care units. In the past few years, another has been entered with the development of methods for more precisely monitoring cardiac function during acute infarction. Hemodynamic monitoring in critically ill patients employs a specially designed double-lumen catheter that can be advanced at the bedside via a peripheral vein to the pulmonary artery without the use of fluoroscopy. Pulmonary artery pressure is monitored through the major lumen that leads to the tip. The minor lumen leads to an inflatable balloon proximal to the catheter tip, which serves to guide the catheter in the direction of blood flow through the right ventricle into the pulmonary artery. Since the balloon can be placed in a position so