tbuckley/cabot-search huggingface dataset:
Promising new treatments for cytomegalovirus retinitis
Authors: M. A. Polis
Journal: JAMA (1995)

THE SURVIVAL of patients infected with the human immunodeficiency virus (HIV) has improved over the past decade due to the use of antiretroviral therapy and better management of acquired immunodeficiency syndrome (AIDS)—related opportunistic infections. Some opportunistic infections are declining in incidence due to the use of effective chemoprophylaxis. From the period 1985 to 1987 to the period 1991 to 1992, for example, the incidence of<i>Pneumocystis carinii</i>pneumonia (PCP) as an AIDS-defining illness in the United States declined from 60.9% to 42.5% (written communication, Jonathan Kaplan, MD, Centers for Disease Control and Prevention, Atlanta, Ga, March 1995). However, as patients live longer with very low CD4 counts, it is not surprising that the incidence of other opportunistic infections has increased. Over the same time intervals, the incidence of cytomegalovirus (CMV) retinitis has increased from 2.8% of AIDS-defining illnesses to 5.9%.<sup>1</sup><i>Pneumocystis carinii</i>prophylaxis has been responsible for much of
Pediatric Neuroradiology
Authors: B.S. Epstein
Journal: JAMA (1973)

This volume correlates the neuroradiologic and neurosurgical experiences of Dr. Raimondi, and is based on his personal experience with 4,500 newborn, infant, and juvenile patients. The first chapter, devoted to normal neuroradiologic anatomy, emphasizes the practical aspects of the relationship of structure to disease as the surgeon sees it. This is followed by a relatively brief section on trauma, particularly hematomas and brain injuries. The section on hydrocephalus is extensive, covering 200 pages, and reflects the author's vast experience with this common disorder. The chapter on tumors, 181 pages long, is particularly interesting in the approach that location of a tumor and not its histology determines its neuroradiologic characteristics. The remainder of the volume provides sections on vascular disease, and infectious diseases of the brain and its covering. Angiographic and pneumoencephalographic examinations are used to supplement each other, and are described together rather than in separate sections. The use of
Temozolomide for the treatment of recurrent glioma: Results of a compassionate use program in Belgium
Authors: B. Neyns, E. Everaert, E. Joosens, T. Strauven, F. Branle, J. Menten
Journal: Journal of Clinical Oncology (2004)

1541 Background: Temozolomide (TMZ) is an oral alkylating agent that has demonstrated objective activity and an acceptable toxicity profile for the treatment of recurrent high-grade gliomas in phase II trials. Only limited information is available on the activity and toxicity of TMZ when prescribed outside a clinical trial. Methods: We conducted a retrospective study to evaluate the activity and safety of TMZ that was prescribed for the treatment of recurrent glioma in the context of a compassionate use program in Belgium. Data were obtained on 117 adult patients (from 5 hospitals) who received TMZ as first or second line chemotherapy. The recommended starting dose of TMZ was 200 mg/m2 x5d q28d for chemonaïve patients and 150 mg/m2 x5d q28d for pretreated patients. Results: Toxicity was generally mild although grade 3/4 toxicity was observed in 22 % of patients. Thrombocytopenia was the most frequent encountered toxicity (grade 3/4 in 17% of patients) and its occurrence was correlated with a starting dose of 200 mg/m2/d. The overall RR (CR + PR) was 29% and 34 % of patients achieved a SD. The median PFS was 104 days (95% CI 85–123) and the median OS was 215 days (95% CI 161–269). In multivariate analysis a “deep localization” of the glioma (as opposed to a cortico-subcortical localization) and the preceding history of a low-grade glioma were identified as independent prognostic variables with regard to TTP & OS. Administration of TMZ as first line chemotherapy was an independent prognostic variable for TTP only. Absence of disease progression at the end of TMZ cycle 3 was significantly correlated with a superior overall survival (landmark analysis, P<0.0001). Conclusions: This retrospective study indicates that the reported activity and toxicity profile of TMZ for the treatment of patients with recurrent glioma is reproducible outside the setting of a prospective clinical trial. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Schering-Plough (Benelux)
Assessing clinical instability at discharge. The clinician's responsibility
Authors: R. H. Brook
Journal: JAMA (1992)

A great deal of attention has been given to what should be hospital policies when a patient is admitted to the hospital. Who should see the patient? At what time after admission? What should constitute an admission history and physical? Very little attention, however, has been paid to determining when it is safe to send a patient home from the hospital. In addition, precious few randomized trials have been performed that use clinical criteria to compare outcomes following discharge for those people who had the "customary" length of stay vs a "medically correct" length of stay.<sup>1,2</sup> A little over a year ago, we wrote a series of articles<sup>3-10</sup>about the impact of diagnosis related group (DRG)—based prospective payment on quality of care for Medicare patients hospitalized with one of five conditions: congestive heart failure, acute myocardial infarction, pneumonia, cerebrovascular accident, and hip fracture. Our data source was a
Enterococcal Endocarditis
Authors: Stanford Wessler
Journal: JAMA (1968)

Dr. Richard Miller*: A 65-year-old white man entered Jewish Hospital on May 19, 1967, with chief complaints of fever, chills, and malaise. He had had a suprapubic prostatectomy on Feb 3, and had required 3 units of blood postoperatively. He was discharged one month later with an hematocrit reading of 30%. Fever and chills occurred in late February, again in March, and one week prior to admission. At the time of the third episode the patient had an oral temperature of 103 F (39.4 C). He was treated with chloramphenicol, but continued to have fever and chills. There was no past history of heart disease, heart murmur, or rheumatic fever. There appeared to be a well-documented allergy to penicillin. Physical examination on admission showed a regular pulse rate of 88 beats per minute, an oral temperature of 100 F (37.8 C), and a blood pressure of 116/68 mm Hg. A
Occupationally Acquired Infections in Health Care Workers: Part II
Authors: Kent A. Sepkowitz
Journal: Annals of Internal Medicine (1996)

Background: Health care workers are at occupational risk for a vast array of infections that cause substantial illness and occasional deaths. Despite this, few studies have examined the incidence, prevalence, or exposure-associated rates of infection or have considered infection-specific interventions recommended to maintain worker safety. Objective: To characterize the type and frequency of infections, the recommended interventions, and the costs of protecting health care workers. Part II of this two-part review focuses on infections caused by bloodborne organisms, organisms spread through the oral-fecal route, and organisms spread through direct contact. It also reviews established interventions for controlling transmission. Data Sources: A MEDLINE search and examination of infectious disease and infection control journals. Data Selection: All English-language articles and meeting abstracts published from January 1983 to February 1996 related to occupationally acquired infections among health care workers were reviewed. Outbreak- and non-outbreak-associated incidence and prevalence rates were derived, as were costs to prevent, control, and treat infections in health care workers. Data Synthesis: Occupational transmission to health care workers was identified for numerous diseases, including infections caused by bloodborne organisms (human immunodeficiency virus, hepatitis B virus, hepatitis C virus, Ebola virus), organisms spread through the oral-fecal route (salmonella, hepatitis A virus), and organisms spread through direct contact (herpes simplex virus, Sarcoptes scabiei). Most outbreak-associated attack rates range from 15% to 40%. Occupational transmission is usually associated with violation of one or more of three basic principles of infection control: handwashing, vaccination of health care workers, and prompt placement of infectious patients into appropriate isolation. Conclusions: The risk for occupationally acquired infections is an unavoidable part of daily patient care. Occupationally acquired infections cause substantial illness and occasional deaths among health care workers. Further studies are needed to enhance compliance with established infection control approaches. As health care is being reformed, the risk for and costs of occupationally acquired infection must be considered.
Random Thoughts.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EEG Findings in Creutzfeldt-Jakob Disease
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevalence and Effects of Mood Disorders on Work Performance in a Nationally Representative Sample of U.S. Workers
Authors: Ronald Kessler
Journal: American Journal of Psychiatry (2006)

Objective: Research on the workplace costs of mood disorders has focused largely on major depressive episodes. Bipolar disorder has been overlooked both because of the failure to distinguish between major depressive disorder and bipolar disorder and by the failure to evaluate the workplace costs of mania/hypomania. Method: The National Comorbidity Survey Replication assessed major depressive disorder and bipolar disorder with the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI) and work impairment with the WHO Health and Work Performance Questionnaire. A regression analysis of major depressive disorder and bipolar disorder predicting Health and Work Performance Questionnaire scores among 3,378 workers was used to estimate the workplace costs of mood disorders. Results: A total of 1.1% of the workers met CIDI criteria for 12-month bipolar disorder (I or II), and 6.4% meet criteria for 12-month major depressive disorder. Bipolar disorder was associated with 65.5 and major depressive disorder with 27.2 lost workdays per ill worker per year. Subgroup analysis showed that the higher work loss associated with bipolar disorder than with major depressive disorder was due to more severe and persistent depressive episodes in those with bipolar disorder than in those with major depressive disorder rather than to stronger effects of mania/hypomania than depression. Conclusions: Employer interest in workplace costs of mood disorders should be broadened beyond major depressive disorder to include bipolar disorder. Effectiveness trials are needed to study the return on employer investment of coordinated programs for workplace screening and treatment of bipolar disorder and major depressive disorder.
Pregnant jogger: what a record!
Authors: M. Korcok
Journal: JAMA (1981)

Maternity jogging clothes are not yet standard issue in most sports stores, but if more women copy one 36-year-old mother who continued her 6.4 km (4 mile) per day running program right up to the day before bearing her seventh child—and then walked the distance on the day of the birth—there may soon be a whole new line of designer togs on the market. The mother, whose case was reported at the annual meeting of the American College of Sports Medicine (ACSM) in Bal Harbour, Fla, was one of a group of pregnant women being tested for aerobic fitness by a team from the Human Performance Research Laboratory and the College of Nursing's division of midwifery at the University of Utah, Salt Lake City. Originally, the program included only pregnant women for whom swimming exercises were prescribed during their last trimester. The intent was to measure any physiological changes occurring
From the NIH: Human wart virus found in many papillomas
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
How can i get a visa to China?
Authors: E. G. Dimond
Journal: JAMA (1975)

THERE evidently lurks in the soul of every American an intense yearning to see China. Beginning in the fall of 1971 down to the time in which I write, a week does not pass without my receiving a letter, phone call, or personal query, in varying styles, the essence of which is "How can I get a visa to China?" The variations on the theme are many. Many are straightforward travel enthusiasts who have been everywhere and are accustomed to the habit that an American tourist is surely welcome everywhere, and now want to add China to their travel list. Other queries fall into the category of "I was there in 1941 and I cannot believe that the flies, beggars, famine, etc, have stopped. I want to go look again." Still others have varied reasons: "I collect porcelains and..." "I have to give a report for my book club about
HELPING THOSE WHO NEED HELP
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMA-RPS Launches Workforce Planning Reform Campaign
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Combination of the Hypercvad Regimen with Dasatinib in Patients with Relapsed Philadelphia Chromosome (Ph) Positive Acute Lymphoblastic Leukemia (ALL) or Lymphoid Blast Phase of Chronic Myeloid Leukemia (CML-LB)
Authors: Theresa Liu-Dumlao, Susan O'Brien, Jorge E. Cortes, Deborah A. Thomas, Stefan Faderl, Elias Jabbour, Charles Koller, Rebecca Garris, Partow Kebriaei, Richard Champlin, Gautam Borthakur, Alessandra Ferrajoli, Hagop M. Kantarjian, Farhad Ravandi
Journal: Blood (2011)
The PARSC trial, a prospective study for the assessment of recurrence risk in stage II colon cancer (CC) patients using ColoPrint.
Authors: R. Salazar, J. Marshall, L. Stork-Sloots, I. Simon, M. Lutke Holzik, J. Tabernero, J. J. Van Der Hoeven, F. Bibeau, R. Rosenberg
Journal: Journal of Clinical Oncology (2010)

TPS199 Background: Clinical trials have not yet shown if adjuvant chemotherapy is justified for stage II CC patients of whom 25% are at risk of recurrence. An 18-gene expression profile, ColoPrint, has been developed for identifying CC cancer patients more likely to develop recurrent disease and who would be candidates for adjuvant chemotherapy. The gene signature has been validated in independent cohorts of 440 CC patients. In one study (Glas et al, ASCO 2009), the profile classified 67% of the stage II patients (n=135) as low-risk. The HR for distant metastasis free survival (DMFS) was 3.27 (p=0.015) with a 5-year DMFS rate of 91% (95%CI 84-98) for low-risk and 72% (95%CI 58-88) for high-risk patients. Moreover, the profile stratified patients independent of ASCO clinical risk factors. Methods: A prospective trial, PARSC (Prospective study for the Assessment of Recurrence risk in Stage II CC patients using ColoPrint) has been initiated. The main objectives are: 1) Determine risk assessment by ColoPrint profile versus clinical parameters based on local protocol and ASCO high-risk recommendations in stage II patients. 2) Establish proportion of
SCARLATINAL INFECTIOUSNESS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal