tbuckley/cabot-search huggingface dataset:
Summary of Conclusions of the Commission on Research
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neoadjuvant rectal cancer (RC) score to predict survival: Potential surrogate endpoint for early phase trials.
Authors: Greg Yothers, Thomas J. George, Nicholas J. Petrelli, Michael J. O'Connell, Robert W. Beart, Carmen Joseph Allegra, Mark S. Roh, Samia H. Lopa, Linda H. Colangelo, Saima Sharif, Norman Wolmark
Journal: Journal of Clinical Oncology (2014)

3533 Background: Valentini, et al. (J Clin Oncol 29: 2011, 3163-72) developed nomograms for predicting overall survival (OS) based on clinical factors available after neoadjuvant therapy (tx). Pathologic T-stage (pT), N-stage (pN), and clinical T (cT) were the most important independent predictors of OS. We developed a neoadjuvant RC score (NAR score) using pN and downstaging of T (cT – pT) based on relative weights suggested by the nomograms. NSABP's R-04 trial presents an opportunity for independent validation of the NAR score. Methods: Pts with clinical stage II/III RC undergoing preoperative RT (4,500cGy in 25 fractions over 5 wks + boost of 540-1080cGy in 3-6 daily fractions) were randomized to one of four regimens in a 2x2 design: CVI 5-FU (225mg/m2 5 days/wk), with or without oxaliplatin (Ox) (50mg/m2 /wk x 5) or oral capecitabine (825 mg/m2 BID 5 days/wk), with or without Ox. The NAR score is computed as [5 pN – 3 (cT – pT) + 12]2 / 9.61 where: cT in {1, 2, 3, 4}, pT in {0, 1, 2, 3, 4}, and pN in {0, 1, 2}. The NAR score takes values from 0 to 100; higher scores indicate poorer prognosis. Analyses based on the score should be stratified by cT. NAR score is compared to pathologic complete response (ypCR) by Akaike's information criterion (AIC) to determine the better predictor of OS. Results: 1,479 pts had data for the NAR score and follow-up for OS. Continuous NAR score was significantly associated with OS (HR/unit 1.04 95% CI 1.03-1.05, p<0.0001). Pts were grouped into low, intermediate, and high risk of death categories based on tertiles of the NAR score. Categories were significantly associated with OS (p<0.0001) with 5yr OS values of 92, 89, and 68%, respectively. ypCR was also significantly associated with OS (HR 0.37 95% CI 0.24-0.58, p<0.0001). Continuous NAR score had a much lower AIC (2902.49) than ypCR (2987.08) suggesting stronger association with OS. Conclusions: The NAR score has been validated as a predictor of OS after neoadjuvant tx for RC. AIC of the continuous NAR score suggests it is a better predictor of OS than dichotomous ypCR. NAR score could be used in place of ypCR as a surrogate endpoint for OS in early phase neoadjuvant rectal trials. Support:U10-CA-12027, U10-CA-37377, U10-CA-69651, U-10-CA-69974; Sanofi; Roche. Clinical trial information: NCT00058474.
NEW (TYPE) FACES OF '65
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SYNOVIAL FLUID
Journal: JAMA (1931)

Methods of scientific precision, which are applied with some success in the diagnosis, prognosis and treatment of many conditions, seem to be almost wholly lacking in the joint diseases. Any data, therefore, that offer possibilities of increased accuracy in any particular should be viewed with critical favor. The synovial fluid appears the most promising available tissue for physical, chemical or biologic study. Forkner<sup>1</sup>has recently examined the literature on this subject and classified the data that have been obtained. It is noteworthy that there is only one reference to observations on the physical and chemical properties of normal synovial fluid. In this the<i>p</i>H is recorded as from 8.2 to 8.4, but Forkner remarks that the extensive work on the<i>p</i>H of pathologic fluids indicates that this result is too high. The report of Seeliger<sup>2</sup>gives the specific gravity as 1.040, total solids as 4.41 per
Irradiation Leukemogenesis
Authors: John S. Lawrence
Journal: JAMA (1964)

Although there is no longer any question about the ability of irradiation to produce leukemia, there remains considerable confusion as to how much danger exists from exposure to irradiation in the normal course of our lives. The general public has much fear of irradiation for diagnostic and therapeutic purposes; some physicians share this fear, while others tend to disregard it. Many persons are concerned about the dangers incurred from irradiation due to fallout associated with detonation of atomic bombs, others have no fear of this type of irradiation exposure, and some are in a state of confusion about it. Still again, the question of a threshold for irradiation is debatable and subject to various interpretations. I hope to clarify a few of these problems. <h3>Review of Incriminating Evidence</h3> While irradiation has been strongly suspected as one possible cause for leukemia, since the report by Von Jagie et al<sup>1</sup>
In ICU and OR, computers lead the way
Authors: D. Seitman
Journal: JAMA (1983)

Anesthesiology and critical care medicine are two fields that rely heavily on sophisticated machinery in their daily operations. Such technology was discussed extensively at the recent Fourth Annual IEEE Engineering in Medicine and Biology Society Conference in Philadelphia. In one presentation, Robert Sclabassi, MD, PhD, associate professor of neurosurgery, and John Vries, MD, associate professor of neurosurgery, both at the University of Pittsburgh School of Medicine, described a microprocessor (DEC LSI 11/2)-based monitoring system for the neurosurgical intensive care unit (ICU). Monitoring devices are attached in the usual manner to keep track of the ECG, arterial pressure, average perfusion pressure, and average respiratory rate each minute. The computer is programmed to alert the staff when a patient's physiological profile suggests an expanding intracranial lesion. All data, measured and computed, are stored in the computer's memory and can be displayed in graphic and in tabular form on a Tektronix terminal screen
Letter: Prisoner Research
Authors: Louis Lasagna
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The recent "Commentary" by Dr. George Bach-y-Rita deserves a response. Dr. Bach-y-Rita has admirable concerns about the deficiencies in our penal system, and one must admire his desire to improve the lot of those incarcerated by society. I believe, however, that he has unwisely combined his desire to achieve change in prisons with an attack on all prison research, even that which is ethical and defensible. I do not accept his judgment that only those who are in "contact with the free world" can make valid decisions about the degree of risk in participation in an experiment. If Dr. Bach-y-Rita were to visit prison research facilities such as the one in Jackson, Mich, I think he would be reassured about the ability of conscientious investigators, with the aid of advisory "watchdog" bodies, to present information about participation in research that is quite adequate. My own experience with
Cancer and Culture
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
This St Patrick's Day finds no lack of controversy at Irish Medical Journal
Authors: J. F. Henahan
Journal: JAMA (1989)

THE<i>IRISH MEDICAL JOURNAL (IMJ)</i>died in December 1987 and, by most accounts, it was not a pleasant death. The reasons for its sudden and traumatic demise—and recent resurrection—are many and conflicting, depending on the source. Death for the medical monthly came after a distinguished and uninterrupted 50 years of publication. It had gained the reputation both inside and outside the Republic of Ireland as the authentic scientific and medical forum for the country's physicians. What actually killed the journal was a vote taken in October 1987 at the annual meeting in Kilkenny of the Irish Medical Organization (IMO). The IMO, which publishes the journal, is a physician's trade union dedicated to ensuring the professional and economic status of its members. The organization's treasurer delivered a report that indicated that the journal was deeply in the red and that its future looked bleak. Although only a small minority of the
Abstract 15259: Genetically Engineered eNOS Dimer Destabilization Impairs Blood Pressure Reducing Activity of eNOS in Mice
Authors: Tatsiana Suvorava, Stephanie Pick, Georg Kojda
Journal: Circulation (2015)

Endothelial dysfunction and oxidative stress are associated with hypertension but whether endothelial superoxide plays a role in the early development of essential hypertension remains uncertain. In this study we investigated whether eNOS-derived endothelial oxidative stress is involved in the regulation of blood pressure (BP). Normal bovine eNOS (eNOS-Tg) or a novel dimer-destabilized eNOS-mutant harboring a partially disrupted zinc-finger (C101A-eNOS-Tg) was introduced in C57BL/6 mice using the endothelium-specific tie-2 promoter. Mice were monitored for aortic endothelium-dependent relaxation, systolic BP, levels of superoxide and several post-translational protein modifications indicating activity and/or increased vascular oxidative stress. Some groups of mice underwent voluntary exercise training or treatment with SOD mimetic Tempol (1mM). C101A-eNOS-Tg (aorta, skeletal muscle, left ventricular myocardium and lung) showed significantly increased superoxide generation, protein- and eNOS-tyrosine-nitration, eNOS-S-glutathionylation, eNOS1176/79 phosphorylation and Thr172-AMP kinase (AMPKα) phosphorylation as compared to eNOS-Tg and wildtype (WT)-controls. The localization of eNOS-Tg was restricted to endothelium as evidenced by immunohistochemical staining for eNOS and an endothelial-specific marker CD31. Exercise training increased phosphorylation of eNOS and AMPKα in WT while these physiologic adaptations were absent in C101A-eNOS-Tg. Aortic endothelium-dependent relaxation was similar in all strains. In striking contrast, C101A-eNOS-Tg displayed normal BP despite higher levels of eNOS, while eNOS-Tg showed significant hypotension. Tempol completely reversed the occurring protein modifications and significantly reduced BP in C101A-eNOS-Tg but not in WT. We observed that oxidative stress generated by endothelial-specific expression of genetically destabilized C101A- eNOS selectively prevents BP reducing activity of vascular eNOS, while having no effect on aortic endothelial dependent relaxation. Our data suggest that oxidative stress generated by eNOS dimer destabilization contributes to the regulation of blood pressure.
Early Days of the Presbyterian Hospital in the City of New York.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fresh Eyes
Authors: Susan A Glod
Journal: Annals of Internal Medicine (2010)

On Being a Doctor17 August 2010Fresh EyesSusan A. Glod, MDSusan A. Glod, MDFrom Penn State Milton S. Hershey Medical Center, Hershey, PA 17033-0850.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-4-201008170-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The 4:30 p.m. page is hardly a welcome sound to any consultant. The prognosis is especially bleak when you are the palliative care physician on call. I tapped out the familiar extension to the neurology intensive care unit and listened to the story on the other end of the line. After a few sentences, I brightened. I had met this patient the previous month, when I was working as the internal medicine consultant and was already familiar with his case, as well as with his family. I might be able to finish the consult in an hour and still make ... Author, Article, and Disclosure InformationAffiliations: From Penn State Milton S. Hershey Medical Center, Hershey, PA 17033-0850.Corresponding Author: Susan A. Glod, MD, Division of General Internal Medicine, Penn State Milton S. Hershey Medical Center, Mail Code H106, 500 University Drive, PO Box 850, Hershey, PA 17033-0850; e-mail, [email protected]psu.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUsability testing in the hospital 17 August 2010Volume 153, Issue 4Page: 272KeywordsEmotionsEpileptic seizuresFatigueLesionsLung and intrathoracic tumorsNeurologyPalliative careStatus epilepticusVentilatorsVision ePublished: 17 August 2010 Issue Published: 17 August 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Registration of Foreign Physicians
Authors: D. Nathan
Journal: JAMA (1910)

<h3>To the Editor:—</h3> To elucidate further the matter of "Registration of Foreign Physicians," I beg leave to comment on the remarks of the writers of the letters inThe Journal, September 3 and 10. Dr. Honeij is right; I am a Canadian, but again he is wrong, I have no friends who wish to register in the United States in the near future or at any other time. If I did have, I should not need to apologize for them, as I am sure that they would acquit themselves honorably. He is also wrong when he says that I do injustice to American physicians. I reiterate my letter of August 27, and as I spoke truthfully, wherein lieth the injustice? I am sure that the American physician (and not every practitioner is a physician) would rightly resent being classed among the ill-trained aspirants for license to practice in Canada or
TYPHUS FEVER: A STUDY OF DISEASE AND ITS MARTYRS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Effect of a Nitric Oxide Synthase Inhibitor on the Modulation of Airway Responsiveness in Rats
Authors: Johan C. Kips, Romain A. Lefebvre, Renaat A. Peleman, Guy F. Joos, Romain A. Pauwels
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

The possible role of nitric oxide (NO) in the regulation of airway tone remains to be fully explored. In the present study we examined the effect of NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of NO synthase, on airway responsiveness in rats. The effect of L-NAME on endotoxin (lipopolysaccharide; LPS)-induced changes in airway responsiveness was also evaluated. L-NAME (1 mg/kg given intravenously) caused a 33.3 ± 6.9% increase in blood pressure, but did not influence baseline airway tone or the provocative dose of carbachol causing a 50% increase in pulmonary resistance (Rl) (PDR50l). Exposure of F344 rats to LPS induced a transient increase in airway responsiveness at 90 min after exposure, followed by a significant hyporesponsiveness between 9 and 12 h after exposure. L-NAME (1 mg/kg intravenously) did not influence the increase in responsiveness but inhibited the LPS-induced hyporesponsiveness; in LPS-exposed, L-NAME-treated animals, the PD50Rl for carbachol was 3.0 ± 0.1, versus 4.8 ± 0.3 µg/kg in the LPS-exposed, placebo-pretreated group (p < 0.05). The effect of L-NAME was abolished by pretreatment with L-arginine but not with D-arginine. L-NAME did not influence the LPS-induced increase of neutrophils in bronchoalveolar lavage fluid (BALF). These results suggest that in rats, constitutive NO synthesis does not contribute either to basal airway tone or to the basal degree of airway responsiveness, but that inducible NO synthesis mediates endotoxin-induced hyporesponsiveness.
Book Review The Action of Muscles (Including Muscle Rest and Muscle Re-Education) . By Sir Colin Mackenzie, M.D., R.F.C.S., F.R.S. (Edin.), Professor of Comparative Anatomy and Director of the Australian Institute of Anatomy, Camberra, etc. Second Edition with 100 illustrations. Paul B. Hoeber, Inc., New York, 1930. Price $3.50.
Journal: New England Journal of Medicine (1930)