tbuckley/cabot-search huggingface dataset:
A Manual of Medical Treatment or Clinical Therapeutics.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blockade by polyphloretin phosphate of the prostaglandin E1-induced human cutaneous reaction
Authors: JØRGEN SØNDERGAARD, HANS PAULLI JØRGENSEN
Journal: British Journal of Dermatology (2006)

The effect of polyphloretin phosphate (PPP) on the human cutaneous reaction induced by prostaglandin E1 (PGE1) has been studied in thirty subjects. Pre-treatment of the skin with three intradermal injections of 1oo μg PPP reduced by 37% the magnitude of the erythema induced by intradermal injection of 1 μg PGE1. The PGE1induced weal, which is probably mainly due to PGE1-induced endogenous histamine release, was not reduced. The specific nature of the PG-blocking activity of PPP was supported, since PPP did not block the erythema and weal induced by intradermal injection of histamine and bradykinin. Intravenous injection of 100 mg PPP did not reduce the erythema due to intradermal injection of PGE1 probably because of too low tissue concentration of PPP.
A Cluster of Young Patients With Burkitt's Lymphoma and Nasopharyngeal Carcinoma in Central Texas
Authors: Leslie P. Boss
Journal: JAMA (1985)

During a five-month period in 1982, diagnoses were made of Burkitt's lymphoma in three children and nasopharyngeal carcinoma in three teenagers who were residents of a small geographic area of central Texas. The observed number of these two Epstein-Barr virus-related cancers was significantly greater than the number expected in young patients based on Surveillance, Epidemiology, and End Results incidence rates. No epidemiologic associations were found linking any of the patients. Environmental studies including serological assays to determine a specific viral etiology were unrevealing. A search for new agents and the preservation of materials for future studies should continue to be a high priority in the evaluation of cancer clusters. (<i>JAMA</i>1985;253:2843-2846)
Measles Antibody Titers in Multiple Sclerosis Patients, Siblings, and Controls
Authors: Thomas E. Henson
Journal: JAMA (1970)

Measles titers were studied among multiple sclerosis (MS) patients and carefully selected controls. The controls consisted of siblings born within three years of the patient, and lifelong friends who were brought up in the same community and attended the same schools as the patient. In addition, serum from the spouses of MS patients was tested. Our results confirm other reports that MS patients have slightly higher titers to measles antigens than unrelated controls. Siblings, however, had titers as high as those encountered among MS patients, suggesting that the elevation was a familial phenomenon. Women had higher measles titers than men among patients and controls indicating that sex was an independent variable in analysis of measles antibody levels.
Blood Transfusions and Mortality Among Critically Ill Patients—Reply
Authors: Jean-Louis Vincent
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Altered Immunity and Cancer Risk: A Review of the Problem and Analysis of the Cancer Mortality Experience of Leprosy Patients
Authors: Arthur Oleinick, M.D., M.P.H.
Journal: JNCI Journal of the National Cancer Institute (1969)

An analysis of the cancer mortality experience of 848 white and Negro leprosy patients admitted to the U.S. Public Health Service Hospital at Carville, Louisiana, was undertaken. With a person-years-at-risk analysis and age, sex, race, and calendar-specific U.S. cancer mortality rates, 19.7 cancer deaths were expected and 21 were observed. Two cases of leukemia/lymphoma were observed when 1.7 were expected. The results of this study provide no support for the hypotheses that defects of cellular immunity play an important role in the pathogenesis of human malignancies or that chronic intense stimulation of the lymphoreticular system predisposes that system to malignant transformation.
Diagnosis of Extrahepatic Portal Vein Obstruction
Authors: Ruben Pochaczevsky
Journal: JAMA (1972)

<h3>To the Editor.—</h3> In a recent article by Yale and Crummy entitled "Splenic Vein Thrombosis and Bleeding Esophageal Varices," the value of splenoportography and transarterial portography was emphasized in the preoperative evaluation of patients with bleeding gastroesophageal varices to allow identification of extrahepatic or segmental portal hypertension.<sup>1</sup>The authors correctly pointed out that the proper treatment of patients with extrahepatic portal obstruction should include splenectomy. In their excellent article, however, the authors did not mention another angiographic study, umbilical vein portography. The following case report is abstracted from previous papers.<sup>2,3</sup> <h3>Report of a Case.—</h3> A 58-year-old man was admitted because of massive hematemesis and melena. Marked splenomegaly was present, but the liver was not enlarged. Aside from leukocytosis, laboratory values, including liver-function tests, were within normal limits. An x-ray film series of the upper-gastrointestinal tract disclosed large esophageal, gastric, and duodenal bulb varices. A duodenal ulcer was suspected.
History
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intrauterine Infections.
Authors: Akos Jakobovits
Journal: Annals of Internal Medicine (1973)

A broad variety of microorganisms are capable of causing fetal infections. Among viral agents prominent are the human cytomegaly virus (HCMV), herpes simplex virus (HSV), human immundeficiency virus (HIV), varicella, herpes zooster, rubella, parvovirus B19, measles and the hepatitis B and C viruses. Protozoa such as toxoplasma and spirocheta pallida, causing congenital syphilis are equally important. Bacterial infections are responsible for in uterus aquired listeriosis, tuberculosis, and group B streptococcus infections. Fungi including candida albicans complete the circle of infections pathogens. Infectious microrganisms may reach the fetus through the placenta are may ascend through the birth canal. The quoted pathological agents threaten the health and life of the fetus directly by the biological derangements they cause and also by inducing abortion or premature birth. The clinical manifestations include retarded growth, central nervous system damage and skin lesions. The invariable therapeutic measures vary but in general, are limited value in cases of in utero acquired infections.
The Future of the Department of Veterans Affairs
Authors: David W. Moskowitz
Journal: JAMA (1995)

<h3>To the Editor.</h3> —The recent article by Drs Fisher and Welsh<sup>1</sup>and the Editorial by Dr Pittman<sup>2</sup>illustrate that the future of the Department of Veterans Affairs (VA) is no less than the future of academic medicine. The future of both relies on solving the health care crisis, which itself is due to the following three main problems: escalating costs, lack of preventive health care for 40 million uninsured Americans, and the impending bankruptcy of academic medical centers.<sup>3</sup> The VA's future is grim because of both demographic and financial considerations. The VA will soon lose its major patient base for the past 50 years—World War II and Korean War veterans now in their 60s and older. Even if the VA could lure more veterans and their families away from the private health care sector, it still faces the impossible task of competing with private health maintenance organizations
The Poor Quality of Early Evaluations of MRI
Authors: John L. Doppman
Journal: JAMA (1988)

<h3>To the Editor.—</h3> The article by Cooper et al<sup>1</sup>and the accompanying editorial by Dr Sheps<sup>2</sup>in the June 10 issue of<i>JAMA</i>point out important deficiencies in research methods in the early clinical magnetic resonance imaging (MRI) literature (1980 to 1984). Clearly, these criticisms are valid. Only with blinded performance and interpretation of examination can MRI be truly assessed. However, we disagree with the implication that sensitivity, specificity, and receiver-operating characteristic analysis provide a uniquely proper and complete format for the evaluation of radiographic results and that their underutilization by the radiology community implies ignorance about or lack of concern for proper analysis. At the crux of the problem is a lack of appreciation by the authors of the unique nature and complexity of anatomic/spatial information and the importance of anatomic diagnosis. The 2×2 table and receiver-operating characteristic analysis incompletely assess the capacity of images to detect,
OPTICAL CLASSIFICATION OF NEOPLASTIC COLORECTAL POLYPS – A COMPUTER ASSISTED APPROACH (THE COACH STUDY)
Authors: P Klare, J Renner, B Haller, Y Saint-Hill-Febles, D Mateus, T Ponchon, C Schlag, A Poszler, RM Schmid, S Delius, F Navarro-Avila
Journal: Endoscopy (2018)

Clinical data suggest that quality of optical diagnoses of colorectal polyps differ markedly among endoscopists. Therefore new technologies are wanted in order to assist endoscopists in their decisions on optical polyp characterization. The aim of this study was to develop a computer program being able to differentiate neoplastic from non-neoplastic polyps using unmagnified endoscopic pictures.
Routine Growth and Differentiation on Primary Retinoblastoma Cells in Culture&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Emil Bogenmann, Corey Mark
Journal: JNCI Journal of the National Cancer Institute (1983)

The lack of systems permitting the routine growth of primary retinoblastomas has been a hindrance in the study of basic properties of these neoplastic cells. Therefore, a new culture system has been developed in which all retinoblastomas, regardless of their origin (primary eye tumor and/or its metastasis, subcutaneous and/or intraocular xenograft from the nude mouse), showed consistent growth. Each tumor could be grown for an unflmited number of culture passages with the use of rat smooth muscle cell multilayers as a biologic substrate and human serum as a culture medium supplement. Several of the tumor lines were continuously grown for longer than 1 year. Labeling with [3H]thymidine for 16 hours demonstrated that between 15 and 40% of the retinoblastoma cells were labeled, depending on the individual neoplasm. Retinoblastomas were organized into clumps of cells that adhered to the smooth muscle cells. The tumor cells maintained a round morphology, and cell spreading was observed in only a few cases. Cultured retinoblastomas consistently showed spontaneous formation of well-differentiated Flexner-Wintersteiner rosettes if these structures were present in the primary eye tumor of the patient. Thus the culture system consistently permitted the growth of retinoblastomas and their photoreceptor cell differentiation.
Endoscopy International Open – recently published
Journal: Endoscopy (2017)

Comment on: Comparison of the diagnostic ability of blue laser imaging magnification versus pit pattern analysis for colorectal polypsEndosc Int Open 2017; 05(04): E224-E231DOI: 10.1055/s-0043-102400 Comment on: International multicenter comparative trial of endoscopic ultrasonography-guided gastroenterostomy versus surgical gastrojejunostomy for the treatment of malignant gastric outlet obstructionEndosc Int Open 2017; 05(04): E275-E281DOI: 10.1055/s-0043-101695 Comment on: Clinical usefulness of magnifying endoscopy for non-ampullary duodenal tumorsEndosc Int Open 2017; 05(04): E297-E302DOI: 10.1055/s-0043-103681
Malaria: Submerged Awareness
Authors: Kristopher N. Hartwig
Journal: JAMA (1996)

<h3>To the Editor.</h3> —Having worked between 1988 and 1995 in rural Tanzania, I appreciated seeing an article in<i>JAMA</i>regarding the ongoing problems of malaria. However, I would raise some questions regarding the observations made by Dr Olliaro and colleagues.<sup>1</sup> First, has malaria ever "submerged"? Have morbidity and mortality on a worldwide basis really improved since the introduction of chloroquine, or since the World Health Organization Malaria Eradication Campaign of 1957? I would suggest not. Rather, our consciousness of malaria has submerged due to (1) the heretofore ease of treatment and (2) the acquired immunodefiency syndrome epidemic superseding interest and funding in areas previously known for malaria research and control. Further, the 1993 tally of 805 300 deaths attributed to malaria<sup>2</sup>(mostly children) can in no way begin to measure the morbidity—particularly in holoendemic regions—of nearly constant exposure to the parasites. Many deaths due to pneumonia and diarrheal
Most antiarthritic agents injure Gl mucosa
Authors: William Golden
Journal: JAMA (1980)

Most anti-inflammatory agents used in the treatment of arthritis can cause erosions in duodenal as well as gastric mucosa. According to a recent study reported by Frank L. Lanza, MD, Houston, at the American College of Gastroenterology meeting in Anaheim, Calif, only enteric-coated aspirin caused minimal damage to the linings of both the stomach and the duodenum. Buffered aspirin did not afford any greater protection than regular aspirin. The observations were based on a study of 40 healthy volunteers between the ages of 21 and 45 years with no prior history of gastrointestinal disease, bleeding disorders, or drug intolerance. All subjects underwent endoscopic visualization of their gastric and duodenal mucosa at the start of the study. They then received one of the following medications at the highest dosage recommended for daily use: aspirin, buffered aspirin, enteric-coated aspirin, a nonsteroidal anti-inflammatory agent (ibuprofen, tolmentin sodium, naproxen, or indomethacin), or a placebo.
IMMUNIZATION AGAINST POLIOMYELITIS
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Essentials of health economics
Authors: P. V Scott
Journal: BMJ (1982)

epidemiological studies.In view of the systematic interlaboratory difference of 0-2 cm it would be wise for each laboratory to derive their own normal data as a reference standard.Finally, the value of the technique in clinical medicine will remain unclear until the exact origin of the echoes has been identified.It is thus important that more fundamental research is undertaken to resolve this uncertainty.
BALB/c Mice Fed Milk or Beef Protein: Differences in Response to 1,2-Dimethylhydrazine Carcinogenesis&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Robert L. Nutter
 6, Daila S. Gridley, James D. Kettering, A. Gordon Goude, James M. Slater
Journal: JNCI Journal of the National Cancer Institute (1983)

The development of 1.2-dimethylhydrazine (DMH)-induced colon tumors and immune responses were investigated in male BALB/c mice fed six different equicaloric diets. Milk or beef at a low (11%) or high (33%) level supplied the dietary protein. and com oil (primarily) at a low (5%) or high (30%) level supplied the fat. Eleven weekly injections of DMH (at 20 mg/kg mouse) or saline were administered. At 59 weeks of age. the milk-fed mice had a significantly higher (P≤.05) colon tumor incidence than the beef-fed mice. 67 and 16%. respectively. Tumor volume and colon weight in the milk-fed mice were also significantly greater. Low natural killer cell activity against [125I]5- iodo-2′-deoxyuridine-labeled colon tumor celis and high serum blocking of antitumor cell activity were observed in the milk-fed mice. These mice also exhibited higher T -lymphocyte cytotoxicity against colon tumor cells. These results differ from those of our previous studies and those of numerous epidemiologic investigations.
Stimulation of naïve B cells with a fusion protein consisting of <scp>FlaA</scp> and Bet v 1 induces regulatory B cells ex vivo
Authors: Alexandra Goretzki, Yen‐Ju Lin, Clara Meier, Britta Dorn, Sonja Wolfheimer, Annette Jamin, Maike Schott, Andrea Wangorsch, Stefan Vieths, Thilo Jakob, Stephan Scheurer, Stefan Schülke
Journal: Allergy (2022)

Abstract Background The experimental fusion protein rFlaA:Betv1 was shown to efficiently suppress allergen‐specific sensitization in mice. However, the detailed mechanism of rFlaA:Betv1‐mediated immune modulation is not fully understood. In this study, we investigated the effect of rFlaA:Betv1 on naïve murine B cells. Methods Immune modulating capacity of rFlaA:Betv1 was screened in IL‐10 reporter mice. B cells were isolated from spleens of naïve C57Bl/6, TLR5 −/− , or MyD88 −/− mice, stimulated with rFlaA:Betv1 and controls, and monitored for the expression of the regulatory B cell markers CD1d, CD24, CD38, and surface IgM by flow cytometry. Secreted cytokines, antibodies, and reactivity of the induced antibodies were investigated by ELISA and intracellular flow cytometry. Suppressive capacity of rFlaA:Betv1‐stimulated B cells was tested in mDC:CD4 + T cell:B cell triple cultures. Results Upon in vivo application of rFlaA:Betv1 into IL‐10‐GFP reporter mice, CD19 + B cells were shown to produce anti‐inflammatory IL‐10, suggesting B cells to contribute to the immune‐modulatory properties of rFlaA:Betv1. rFlaA:Betv1‐induced IL‐10 secretion was confirmed in human B cells isolated from buffy coats. In vitro stimulation of naïve murine B cells with rFlaA:Betv1 resulted in an mTOR‐ and MyD88‐dependent production of IL‐10 and rFlaA:Betv1 induced Bet v 1‐reactive IgG production, which was not observed for IgA. rFlaA:Betv1‐stimulated B cells formed a CD19 + CD24 + CD1d + IgM + CD38 + Breg subpopulation capable of suppressing Bet v 1‐induced TH2 cytokine secretion in vitro. Conclusion rFlaA:Betv1 can act as a thymus‐independent B cell antigen, stimulating the mTOR‐ and MyD88‐dependent differentiation of B cells displaying a regulatory phenotype, IL‐10 secretion, antigen‐binding antibody production, and a suppressive capacity in vitro.
'Electronic hearing' draws mixed reviews
Authors: Barbara Burke
Journal: JAMA (1982)

An electronic hearing system has enabled more than 50 people who were classified as totally deaf to understand some speech, according to its inventor, French surgeon Claude-Henri Chouard, MD, a professor at the University of Paris medical school. The method involves implantation of 12 electrodes in the inner ear to stimulate the auditory nerve. It has been used for both congenital and acquired deafness, and the first patients, operated on more than five years ago, continue to have some hearing capacity. Based on results so far, Chouard estimates that this system could give some understanding of speech to 80% to 90% of those who are totally deaf and could enable 60% to understand speech reasonably well, although not as well as people with normal hearing. In the United States, an estimated 200,000 to 300,000 persons are totally deaf. However, one American researcher calls Chouard's technique "quite controversial," and Michel Portmann,