tbuckley/cabot-search huggingface dataset:
Correction
Journal: BMJ (1954)

BRrr L ANY QUESTIONS?~~~~~~~~~~~~MEOnICAL-JOLINA (Chr.prodigiosum) in the mouth, and studying the fate of the bacteria so deposited by subsequent quantitative cul- ture.Silver is itself bactericidal, and a rapid fall in the numbers of bacteria recoverable was observed in comparison with their behaviour when similarly deposited on a glass slide.Moreover, the wiping of a smooth surface with a fine linen fabric mechanically removes anything deposited on it with a-high degree of efficiency, and reduc- tions in bacterial counts of 90% were observed to result from this process alone.From these and other experi- ments the authors were satisfied that the risk involved is very small, and it is said that in fact no instance of the transmission of infection by this means has ever been sub- stantiated.Their least satisfactory evidence concerns Myco.tuberculosis.Experiments with this species were not quanti- tative, and were concerned only with survival on the sur- face of the chalice without wiping, but all guinea-pig tests up to 40 minutes after contamination were positive.
ON RETROPERITONEAL AND PERIRENAL LIPOMA.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the Centers for Disease Control and Prevention. Adult blood lead epidemiology and surveillance--United States, third quarter, 1993
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heterogeneous expression of CD5, CD10, and CD23 in Waldenstrom's macroglobulinemia
Authors: T. Cafarella, R. Manning, Z. Hunter, A. R. Branagan, O. Tournilhac, D. D. Santos, D. M. Dorfman, S. P. Treon
Journal: Journal of Clinical Oncology (2004)

6730 Background: Waldenstrom's macroglobulinemia (WM) is a B-cell malignancy, recently established by a consensus panel to be represented by the underlying WHO/REAL pathological diagnosis of IgM secreting lymphoplasmacytic lymphoma (Semin Oncology 30:110, 2003). The expression of CD5, CD10, and CD23 in WM remains controversial, and confusion with other B-cell malignancies has often resulted. Methods: We examined the expression of CD5 (L17F12 mAb), CD10 (J5 mAb), and CD23 (EBVCS-5 mAb) by multicolor flow cytometry on bone marrow lymphoplasmacytic lymphoma cells (CD19+, LC restricted) taken from patients with a consensus panel defined diagnosis of WM, and correlated these findings with important clinical and laboratory features at presentation. Results: Antigen expression was as follows: CD5 (10.7%; N=103); CD10 (10.1%; N=89); and CD23 (20%; N=60). No significant differences in age, serum IgM, serum viscosity, and beta 2 microglobulin levels, as well as complete blood counts were observed in patients with and without expression of CD5, CD10, or CD23 at the time of initial presentation. However, increased bone marrow (BM) involvement by tumor cells was observed among patients expressing CD10 (55% vs. 30%; p=0.01), who also displayed more pronounced IgG (505 vs. 661 mg/dL; p=0.01) and IgA (40 vs. 59 mg/dL; p=0.0001) hypoglobulinemia. A trend for greater BM involvement (40% vs. 20%; p=0.11), as well as more pronounced IgA hypoglobulinemia (32 vs. 55 mg/dL; p=0.01) was also observed among patients with CD23+ disease. Patients with CD10, but not CD5, or CD23 expression also had a higher incidence of familial disease, defined as having a first degree relative with WM or a closely related B-cell disorder (55.5% vs. 25%; p=0.10). Conclusions: These data suggest that CD5, CD10, and CD23 are commonly expressed antigens in WM, and their presence should not exclude the diagnosis of WM. Moreover, expression of CD10 or CD23 may have important clinical implications, and define a subset of WM. No significant financial relationships to disclose.
World Congress of Gastroenterology, Digestive Endoscopy, and Colo-Proctology
Journal: JNCI Journal of the National Cancer Institute (1982)

Journal Article World Congress of Gastroenterology, Digestive Endoscopy, and Colo-Proctology Get access JNCI: Journal of the National Cancer Institute, Volume 68, Issue 3, March 1982, Page 535, https://doi.org/10.1093/jnci/68.3.535-f Published: 01 March 1982
The Treatment of Injuries of the Head and Spine
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review The Diagnosis and Treatment of Pulmonary Tuberculosis . By John B. Hawes, 2nd., M.D.; and Moses J. Stone, M.D. Second edition. With a foreword by Richard C. Cabot, M.D. 8°, cloth, 260 pp., with 75 illustrations. Philadelphia: Lea and Febiger, 1940. $2.75.
Journal: New England Journal of Medicine (1941)
Ethics committees and decisions to limit care. The experience at the Massachusetts General Hospital
Authors: T. A. Brennan
Journal: JAMA (1988)

Decisions to limit care for terminally ill patients present a number of ethical and legal issues. For the past 13 years, the Optimum Care Committee (OCC) of the Massachusetts General Hospital, Boston, has provided advice for physicians faced with such issues. I have reviewed the experience of the committee with the 73 cases on which it provided consultation from 1974 through 1986. In addition, I have compared these cases with those of all 113 patients at the Massachusetts General Hospital who were accorded do-not-resuscitate status without OCC input during a three-month period and found that the two groups differed significantly on a number of clinical variables. I have also found that the OCC cases fall into six categories, each of which presents different ethical and legal issues. In addition, the use of the OCC within the hospital is increasing especially with regard to certain categories of cases. The committee has dealt with controversial issues in a consistent and ethically forthright manner, but legal and moral questions remain. More discussion of the role of ethics committees in withdrawal-of-care cases is needed. (<i>JAMA</i>1988;260:803-807)
Repair of traumatic rupture of the aortic arch
Authors: J. C. Kiser
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Traumatic rupture of the thoracic aorta has interested surgeons for many years. The mechanism and the methods of treatment have been widely discussed. The most common site of injury is at, or just distal to, the left subclavian artery. Traumatic rupture of the transverse portion of the arch is unusual. With reliable and safe techniques of extracorporeal circulation, the treatment of this injury depends largely upon early and precise diagnosis. Perhaps as many as 80% of these patients die immediately.<sup>1</sup>However, of those surviving the initial insult, the salvage rate by currently available techniques should be substantial. <h3>Report of a Case:—</h3> A 23-year-old man was seen in the emergency room at 3:37 PM, June 7, 1967, after having been pinned between two trucks in a gravel pit two hours earlier. Initial examination revealed only a contusion over the mid sternum and the right side of the
Children in women's refuges have unmet health needs
Journal: BMJ (2001)

Evidence on health effects of housing improvements is scarce Despite strong observational evidence linking housing and health, it is still not known if housing improvements can improve health.Thomson et al (p 187) conducted a systematic review of studies of housing interventions on health.Although many of the studies found that health improved after the interventions, the studies were small and often did not adjust for potential confounding factors.
Cutting medical care costs. Primum non nocere
Authors: R. J. Blendon
Journal: JAMA (1983)

A serious slowdown in the nation's economy has led to widespread agreement that the rate of escalation of medical care costs must be slowed. In responding to the pressures to cut costs, physicians need to be guided by the basic tenet of medicine: first do no harm. In recent years, this nation has made extraordinary progress in improving health and longevity. A recent study suggestively links reductions in mortality to increased expenditures for health. Thus, physicians should watch closely how the nation reduces medical care expenses. We suggest a series of yardsticks that might track the effects of the nation's cost-cutting efforts on personal health. Keeping a careful eye on where people receive care, how frequently they see a physician, trends in mortality, and the adequacy or timeliness of care could help us keep our sights set on the continuing improvement of the health of Americans. (<i>JAMA</i>1983;250:1880-1885)
Book Review The Surgery of Pain . By René Leriche, M.D. (Lyon), LL.D. (Glas.), F.R.C.S. Eng. (hon. causa), and so forth. Translated and edited by Archibald Young. 8°, cloth, 512 pp., with 18 illustrations. Baltimore: Williams &amp; Wilkins Company, 1939. $6.50.
Journal: New England Journal of Medicine (1940)
Eosinophilia-Myalgia Syndrome or Fibromyalgia With Eosinophilia?-Reply
Authors: Mary L. Kamb
Journal: JAMA (1993)

<h3>In Reply.</h3> —Drs Hudson, Daniels, and Horwitz suggest that the CDC surveillance definition allowed misclassification of patients with other myalgia causing illnesses (such as fibromyalgia) as having EMS, thus overestimating the magnitude of the 1989 epidemic. Misclassification is possible with any surveillance definition.<sup>1</sup>However, the criteria for EMS surveillance are quite rigorous, requiring eosinophil counts greater than 1.0×10<sup>9</sup>/L in addition to incapacitating myalgia.<sup>2</sup>Although severe myalgia occurs in many conditions, an eosinophil count greater than 1.0×10<sup>9</sup>/L is unusual. We believe the strict surveillance definition minimized overreporting, and has probably led to substantial underreporting of EMS. The logistics of public health surveillance typically do not allow extensive medical record review by public health officials.<sup>1</sup>However, we agree that more specific, analytic investigations of tryptophan use and EMS should include careful evaluation for preexisting conditions involving myalgia and eosinophilia. In the 1990 investigation in South
Benzodiazepine drug use and adverse respiratory outcomes among older adults with COPD
Authors: Nicholas T. Vozoris, Anne L. Stephenson
Journal: European Respiratory Journal (2015)

We thank R. Katyal for his comments on our study as he raises some interesting points. Although there are some other physiology studies showing no association between benzodiazepine receipt and negative respiratory effects among individuals with chronic obstructive pulmonary disease (COPD) [1, 2], physiology studies are limited in their ability to provide information on the true clinical impact of benzodiazepines in the COPD population. This is because they generally include small numbers of participants, administration of only a single benzodiazepine dose, short follow-up and do not examine for clinically meaningful respiratory outcomes. In contrast, our study [3] included a large population-based sample, real-world benzodiazepine doses and durations, a longer follow-up period, and important and relevant clinical respiratory outcomes. Benzodiazepines, regardless of half-life, are associated with adverse respiratory outcomes across COPD severity <http://ow.ly/DgoFp>
Toward a 21st-Century Health Care System: The Devil Is in the Details
Authors: Philip Cohen
Journal: Annals of Internal Medicine (2009)

Letters1 September 2009Toward a 21st-Century Health Care System: The Devil Is in the DetailsPhilip Cohen, PA-C, AASPhilip Cohen, PA-C, AASFrom Sterling, VA 20165.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-5-200909010-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I found few specific actions proposed in the article by Arrow and colleagues (1). Everyone agrees that identifying good practices and cost-effective tests and treatments is desirable; eliminating waste and moderating greed is a noble aspiration. Universal access to basic preventive and emergency care is the only rational choice. As usual, the devil is in the details. Nobody wants to be left holding the bag for an expensive, out-of-control health care system. Therefore, first and foremost, we need to agree on an equitable way to pay for services in which everybody is a stakeholder.I propose a ...Reference1. Arrow K, Auerbach A, Bertko J, Brownlee S, Casalino LP, Cooper J, et al. Toward a 21st-century health care system: recommendations for health care reform. Ann Intern Med. 2009;150:493-5. [PMID: 19258550] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Sterling, VA 20165.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoToward a 21st-Century Health Care System: Recommendations for Health Care Reform Kenneth Arrow , Alan Auerbach , John Bertko , Shannon Brownlee , Lawrence P. Casalino , Jim Cooper , Francis J. Crosson , Alain Enthoven , Elizabeth Falcone , Robert C. Feldman , Victor R. Fuchs , Alan M. Garber , Marthe R. Gold , Dana Goldman , Gillian K. Hadfield , Mark A. Hall , Ralph I. Horwitz , Michael Hooven , Peter D. Jacobson , Timothy Stoltzfus Jost , Lawrence J. Kotlikoff , Jonathan Levin , Sharon Levine , Richard Levy , Karen Linscott , Harold S. Luft , Robert Mashal , Daniel McFadden , David Mechanic , David Meltzer , Joseph P. Newhouse , Roger G. Noll , Jan B. Pietzsch , Philip Pizzo , Robert D. Reischauer , Sara Rosenbaum , William Sage , Leonard D. Schaeffer , Edward Sheen , B. Michael Silber , Jonathan Skinner , Stephen M. Shortell , Samuel O. Thier , Sean Tunis , Lucien Wulsin Jr. , Paul Yock , Gabi Bin Nun , Stirling Bryan , Osnat Luxenburg , and Wynand P.M.M. van de Ven Toward a 21st-Century Health Care System: The Devil Is in the Details Lester Mayers Toward a 21st-Century Health Care System: The Devil Is in the Details Robert M. Hansen Toward a 21st-Century Health Care System: The Devil Is in the Details Umesh Gidwani Metrics 1 September 2009Volume 151, Issue 5Page: 366-367KeywordsConflicts of interestHealth careHealth insuranceMedicarePreventive medicine ePublished: 1 September 2009 Issue Published: 1 September 2009 CopyrightCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
07.02 Genetic signatures in rheumatoid arthritis: changes upon anti-tnf therapy and association with response to biological treatment
Authors: Attila Hamar, Szilárd Poliska, Edit Végh, Anita Pusztai, Andrea Váncsa, Szilvia Szamosi, Mária Csumita, Gábor Zahuczky, Gabriella Szűcs, Sándor Szántó, László Nagy, Zoltán Szekanecz
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Genetic signatures may be involved in the pathogenesis of rheumatoid arthritis (RA) and ankylosing spondylitis (AS). In addition, such genetic patterns may change overtime upon treatment with anti-TNF biologics. With respect to pharmacogenomics, pre-treatment genomics may predict response or non-response to biological therapy. <h3>Objectives</h3> In the present study, we wished to determine gene expression changes due to anti-TNF therapy. Furthermore, we wished to study associations between baseline genetic signature and response to TNF blockade. <h3>Patients and methods</h3> Altogether 23 RA and 17 AS patients were recruited for the study. Among RA patients, 10 received certolizumab pegol (CZP), and 13 etanercept (ETN). All AS patients were treated with ETN. Gene expression analysis using Affymetrix microarray and PrimeView array was performed at baseline and after 2 weeks of treatment. EULAR response criteria were used to differentiate responders (R) from non-responders (NR) after 12 weeks of treatment using GeneSpring software. Principal Component Analysis (PCA) was also performed. Changes in gene expression patterns were also determined between baseline and 2 weeks. <h3>Results</h3> In the CZP-treated RA group, 4 patients were R and 6 were NR. Altogether 453 genes showed significantly differential expression between N and NR. In the RA-ETN group, 10 patients were R, and 3 were NR. Here, 836 genes exerted differential expression. When a CZP- and ETN-treated patients, were pooled, 165 genes separated R from NR. In the AS population, 14 patients were R and 3 were NR. 177 genes differentiated between R and NR. When changes in gene expression patterns from baseline to week 2 were determined, in the RA-CZP, RA-ETN, RA-all and AS groups 370, 79, 24 and 76 genes showed significant changes in expression. <h3>Conclusions</h3> Using microarray, genetic signatures may differentiate RA patients responding or not responding to anti-TNF therapy. Furthermore, a large set of genes show differential expression before versus 2 weeks after biologic treatment.
Recovery is quicker after laparoscopic hernia repair---but there is a cost
Journal: BMJ (1998)

Recovery is quicker after laparoscopic hernia repair-but there is a cost Repair of inguinal hernias is one of the most common surgical procedures.Surgeons are increasingly using a preformed synthetic mesh to cover the inguinal defect.On p 103 Wellwood et al evaluate the costs and outcomes (both clinical and patient based) of open and laparoscopic mesh repair in a randomised controlled trial of 400 patients.Patients undergoing laparoscopic hernia repair recovered faster and experienced less pain than patients who underwent standard open mesh repair.The laparoscopic procedure, however, was more costly.
HEPATIC VEIN REACTIONS IN CIRCULATORY CORRELATIONS AS EXEMPLIFIED BY EFFECTS OF DIGITALIS AND OTHER DRUGS
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Three-Dimensional Structure of p21 in the Active Conformation and Analysis of an Oncogenic Mutant
Authors: Fred Wittinghofer, Ute Krengel, Jacob John, Wolfgang Kabsch, Emil F. Pai
Journal: Environmental Health Perspectives (1991)

The three-dimensional structure of the active guanosine triphosphate (GTP)-analogue-containing complex of the H-ras-encoded p21 has been determined. It was necessary to correct the topology of p21 as published earlier. The structure analysis shows all of the interactions between protein and GTP and how the important cofactor Mg2+ is bound. From the oncogenic mutants of p21 crystallized, a Gly12 to Arg mutation has been analyzed in detail. It shows that the overall structure of the mutant is not perturbed and that the side chain of Arg12 is coming close to the gamma-phosphate for an interaction.