tbuckley/cabot-search huggingface dataset:
Best Practices for Sharing Images in Clinical Care, Research, and Education—Protecting Patient Privacy
Authors: Kanade Shinkai, Anna L. Bruckner, June K. Robinson
Journal: JAMA Dermatology (2023)

Dermatologic care, research, and education rely on presenting clinical images, case histories, videos, quotations, and other identifiable information to discuss cases with colleagues.The ethical boundaries of patient privacy and patient-physician trust are tested because traditional patient protection has not evolved in parallel or at the same pace as the rapid expansion of online educational conferences, discussion groups, social media, and even machine learning, which enable the dissemination of identifiable information on a much larger scale as well as for secondary uses. 1 This Editorial explores the current standards for protecting privacy rights of patients and research participants, and highlights gaps in these standards where lapses and common secondary usages of private patient information may occur. 2 We make a call to action to dermatologists to lead the development of a comprehensive, unified informed consent process and best practices that balance patient privacy with sharing identifiable information in clinical care, research, and education.
Effects of Specialist Palliative Care for Patients Undergoing Major Abdominal Surgery for Cancer
Authors: Myrick C. Shinall, Sara F. Martin, Mohana Karlekar, Aimee Hoskins, Ellis Morgan, Amy Kiehl, Patsy Bryant, Onur M. Orun, Rameela Raman, Benjamin F. Tillman, Alexander T. Hawkins, Alaina J. Brown, Christina E. Bailey, Kamran Idrees, Sam S. Chang, Joseph A. Smith, Marcus C. B. Tan, Deepa Magge, David Penson, E. Wesley Ely
Journal: JAMA Surgery (2023)

Specialist palliative care benefits patients undergoing medical treatment of cancer; however, data are lacking on whether patients undergoing surgery for cancer similarly benefit from specialist palliative care.
Robotic vs Open Liver Resection for Hepatocellular Carcinoma
Authors: Jie Huang
Journal: JAMA Surgery (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Robotic vs Open Liver Resection for Hepatocellular Carcinoma—Reply
Authors: Fabrizio Di Benedetto, Paolo Magistri, Stefano Di Sandro
Journal: JAMA Surgery (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Treatment of Netherton Syndrome With Abrocitinib
Authors: Chun-Chan Zheng, Xiao-Xuan Chen, Rui-Tao Zou, Gui-Yue Cai, Rong-Yi Chen
Journal: JAMA Dermatology (2023)

This case report describes a 28-year-old woman with Netherton syndrome who had large erythematous migratory patches with serpiginous double-edged scales on her face, neck, trunk, and extremities.
Efficacy of Integrated Online Mindfulness and Self-compassion Training for Adults With Atopic Dermatitis
Authors: Sanae Kishimoto, Norio Watanabe, Yosuke Yamamoto, Takumi Imai, Rei Aida, Christopher Germer, Risa Tamagawa-Mineoka, Ryosuke Shimizu, Steven Hickman, Yujiro Nakayama, Takafumi Etoh, Ethan Sahker, Martha B. Carnie, Toshi A. Furukawa
Journal: JAMA Dermatology (2023)

Quality of life (QOL) of patients with atopic dermatitis (AD) is reported to be the lowest among skin diseases. To our knowledge, mindfulness and self-compassion training has not been evaluated for adults with AD.
Robotic vs Open Liver Resection for Hepatocellular Carcinoma
Authors: Henghai Yu, Xiaoping Wei
Journal: JAMA Surgery (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Surgical Palliative Care—Who, When, and Why?
Authors: Jason Michael Johanning, Ana Berlin, Pringl Miller
Journal: JAMA Surgery (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
The integrated LIM-peptidase domain of the CSA1-CHS3/DAR4 paired immune receptor detects changes in DA1 peptidase inhibitors in Arabidopsis
Authors: Benguo Gu, Toby Parkes, Fernando Rabanal, Caroline Smith, Fu-Hao Lu, Neil McKenzie, Hui Dong, Detlef Weigel, Jonathan D.G. Jones, Volkan Cevik, Michael W. Bevan
Journal: Cell Host & Microbe (2023)

White blister rust, caused by the oomycete Albugo candida, is a widespread disease of Brassica crops. The Brassica relative Arabidopsis thaliana uses the paired immune receptor complex CSA1-CHS3/DAR4 to resist Albugo infection. The CHS3/DAR4 sensor NLR, which functions together with its partner, the helper NLR CSA1, carries an integrated domain (ID) with homology to DA1 peptidases. Using domain swaps with several DA1 homologs, we show that the LIM-peptidase domain of the family member CHS3/DAR4 functions as an integrated decoy for the family member DAR3, which interacts with and inhibits the peptidase activities of the three closely related peptidases DA1, DAR1, and DAR2. Albugo infection rapidly lowers DAR3 levels and activates DA1 peptidase activity, thereby promoting endoreduplication of host tissues to support pathogen growth. We propose that the paired immune receptor CSA1-CHS3/DAR4 detects the actions of a putative Albugo effector that reduces DAR3 levels, resulting in defense activation.
Closure of Mesenteric Defects During Gastric Bypass Reduces but Does Not Eliminate the Risk of Internal Hernia
Authors: I. Michael Leitman
Journal: JAMA Surgery (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Sustained remission of type 2 diabetes in rodents by centrally administered fibroblast growth factor 4
Authors: Hongbin Sun, Wei Lin, Yu Tang, Hongqing Tu, Ting Chen, Jie Zhou, Dezhong Wang, Qingqing Xu, Jianlou Niu, Wenliya Dong, Sidan Liu, Xinyan Ni, Wen Yang, Yingzheng Zhao, Lei Ying, Jie Zhang, Xiaokun Li, Moosa Mohammadi, Wei L. Shen, Zhifeng Huang
Journal: Cell Metabolism (2023)
PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression
Authors: Qi Zhou, Leijia Li, Feifei Sha, Yiming Lei, Xuan Tian, Lingjun Chen, Yan Chen, Huiling Liu, Yunwei Guo
Journal: Cancer Research (2023)

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has a poor prognosis. Pituitary tumor transforming gene 1 (PTTG1) is highly expressed in HCC, suggesting it could play an important role in hepatocellular carcinogenesis. Here, we evaluated the impact of PTTG1 deficiency on HCC development using a diethylnitrosamine (DEN)-induced HCC mouse model and a hepatitis B virus (HBV) regulatory X protein (HBx)-induced spontaneous HCC mouse model. PTTG1 deficiency significantly suppressed DEN- and HBx-induced hepatocellular carcinogenesis. Mechanistically, PTTG1 promoted asparagine synthetase (ASNS) transcription by binding to its promoter, and asparagine (Asn) levels were correspondingly increased. The elevated levels of Asn subsequently activated the mTOR pathway to facilitate HCC progression. In addition, asparaginase treatment reversed the proliferation induced by PTTG1 overexpression. Furthermore, HBx promoted ASNS and Asn metabolism by upregulating PTTG1 expression. Overall, PTTG1 is involved in the reprogramming of Asn metabolism to promote HCC progression and may serve as a therapeutic and diagnostic target for HCC.PTTG1 is upregulated in hepatocellular carcinoma and increases asparagine production to stimulate mTOR activity and promote tumor progression.
Current perspectives on mesenchymal stromal cell therapy for graft versus host disease
Authors: Nadir Kadri, Sylvie Amu, Ellen Iacobaeus, Erik Boberg, Katarina Le Blanc
Journal: Cellular and Molecular Immunology (2023)

Abstract Graft versus host disease (GvHD) is the clinical condition in which bone marrow-derived mesenchymal stromal cells (MSCs) have been most frequently studied. In this review, we summarize the experience from clinical trials that have paved the way to translation. While MSC-based therapy has shown an exceptional safety profile, identifying potency assays and disease biomarkers that reliably predict the capacity of a specific MSC batch to alleviate GvHD has been difficult. As GvHD diagnosis and staging are based solely on clinical criteria, individual patients recruited in the same clinical trial may have vastly different underlying biology, obscuring trial outcomes and making it difficult to determine the benefit of MSCs in subgroups of patients. An accumulating body of evidence indicates the importance of considering not only the cell product but also patient-specific biomarkers and/or immune characteristics in determining MSC responsiveness. A mode of action where intravascular MSC destruction is followed by monocyte-efferocytosis-mediated skewing of the immune repertoire in a permissive inflammatory environment would both explain why cell engraftment is irrelevant for MSC efficacy and stress the importance of biologic differences between responding and nonresponding patients. We recommend a combined analysis of clinical outcomes and both biomarkers of disease activity and MSC potency assays to identify patients with GvHD who are likely to benefit from MSC therapy.
Beneficial effects of fecal microbiota transplantation in recurrent Clostridioides difficile infection
Authors: Abbas Yadegar, Sepideh Pakpour, Fathima F. Ibrahim, Ali Nabavi-Rad, Laura Cook, Jens Walter, Anna M. Seekatz, Karen Wong, Tanya M. Monaghan, Dina Kao
Journal: Cell Host & Microbe (2023)
CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4+ T cells
Authors: Yuwei Hao, Bahar Miraghazadeh, Rochna Chand, Ainsley R Davies, Chelisa Cardinez, Kristy Kwong, Morgan B Downes, Rebecca A Sweet, Pablo F Cañete, Lloyd J D'Orsogna, David A Fulcher, Sharon Choo, Desmond Yip, Geoffrey Peters, Sonia Yip, Matthew J Witney, Maxim Nekrasov, Zhi-Ping Feng, David C Tscharke, Carola G Vinuesa, Matthew C Cook
Journal: Cellular and Molecular Immunology (2023)

Abstract As chronic antigenic stimulation from infection and autoimmunity is a feature of primary antibody deficiency (PAD), analysis of affected patients could yield insights into T-cell differentiation and explain how environmental exposures modify clinical phenotypes conferred by single-gene defects. CD57 marks dysfunctional T cells that have differentiated after antigenic stimulation. Indeed, while circulating CD57 + CD4 + T cells are normally rare, we found that they are increased in patients with PAD and markedly increased with CTLA4 haploinsufficiency or blockade. We performed single-cell RNA-seq analysis of matched CD57 + CD4 + T cells from blood and tonsil samples. Circulating CD57 + CD4 + T cells (CD4cyt) exhibited a cytotoxic transcriptome similar to that of CD8 + effector cells, could kill B cells, and inhibited B-cell responses. CTLA4 restrained the formation of CD4cyt. While CD57 also marked an abundant subset of follicular helper T cells, which is consistent with their antigen-driven differentiation, this subset had a pre-exhaustion transcriptomic signature marked by TCF7 , TOX , and ID3 expression and constitutive expression of CTLA4 and did not become cytotoxic even after CTLA4 inhibition. Thus, CD57 + CD4 + T-cell cytotoxicity and exhaustion phenotypes are compartmentalised between blood and germinal centers. CTLA4 is a key modifier of CD4 + T-cell cytotoxicity, and the pathological CD4cyt phenotype is accentuated by infection.
Telemedicine and the environment: life cycle environmental emissions from in-person and virtual clinic visits
Authors: Cassandra L. Thiel, Natasha Mehta, Cory Sean Sejo, Lubna Qureshi, Meagan Moyer, Vincent Valentino, Jason Saleh
Journal: npj Digital Medicine (2023)

Abstract Concern over climate change is growing in the healthcare space, and telemedicine has been rapidly expanding since the start of the COVID19 pandemic. Understanding the various sources of environmental emissions from clinic visits—both virtual and in-person—will help create a more sustainable healthcare system. This study uses a Life Cycle Assessment with retrospective clinical data from Stanford Health Care (SHC) in 2019–2021 to determine the environmental emissions associated with in-person and virtual clinic visits. SHC saw 13% increase in clinic visits, but due to the rise in telemedicine services, the Greenhouse Gas emissions (GHGs) from these visits decreased 36% between 2019 and 2021. Telemedicine (phone and video appointments) helped SHC avoid approximately 17,000 metric tons of GHGs in 2021. Some departments, such as psychiatry and cancer achieved greater GHG reductions, as they were able to perform more virtual visits. Telemedicine is an important component for the reduction of GHGs in healthcare systems; however, telemedicine cannot replace every clinic visit and proper triaging and tracking systems should be in place to avoid duplicative care.
Evidence-Based Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis
Authors: Giacomo Emmi, Alessandra Bettiol, Elena Gelain, Ingeborg M. Bajema, Alvise Berti, Stella Burns, Maria C. Cid, Jan W. Cohen Tervaert, Vincent Cottin, Eugenia Durante, Julia U. Holle, Alfred D. Mahr, Marcos Martinez Del Pero, Chiara Marvisi, John Mills, Sergey Moiseev, Frank Moosig, Chetan Mukhtyar, Thomas Neumann, Iacopo Olivotto, Carlo Salvarani, Benjamin Seeliger, Renato A. Sinico, Camille Taillé, Benjamin Terrier, Nils Venhoff, George Bertsias, Loïc Guillevin, David R. W. Jayne, Augusto Vaglio
Journal: Nature Reviews Rheumatology (2023)
A pan-African pathogen genomics data sharing platform to support disease outbreaks
Authors: Alan Christoffels, Gerald Mboowa, Peter van Heusden, Sello Makhubela, George Githinji, Sarah Mwangi, Harris Onywera, Ndodo Nnaemeka, Daniel Gyamfi Amoako, Idowu Olawoye, Amadou Diallo, Placide Mbala-Kingebeni, Samuel O Oyola, Bright Adu, Christopher Mvelase, Pascale Ondoa, Fred Athanasius Dratibi, Abdourahmane Sow, Nicksy Gumede, Sofonias K Tessema, Ahmed Ogwell Ouma, Yenew Kebede Tebeje
Journal: Nature Medicine (2023)
Author Correction: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial
Authors: R Waziry, C P Ryan, D L Corcoran, K M Huffman, M S Kobor, M Kothari, G H Graf, V B Kraus, W E Kraus, D T S Lin, C F Pieper, M E Ramaker, M Bhapkar, S K Das, L Ferrucci, W J Hastings, M Kebbe, D C Parker, S B Racette, I Shalev, B Schilling, D W Belsky
Journal: Nature Aging (2023)
Correction: Starburst amacrine cells, involved in visual motion perception, lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson’s disease patients
Authors: Xavier Sánchez-Sáez, Isabel Ortuño-Lizarán, Carla Sánchez-Castillo, Pedro Lax, Nicolás Cuenca
Journal: Translational Neurodegeneration (2023)

Starburst amacrine cells, involved in visual motion perception, lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson's disease patients.
Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer
Authors: Yueqin Wang, Jingyao Wei, Luyao Feng, Ouwen Li, Lan Huang, Shaoxuan Zhou, Yingjie Xu, Ke An, Yu Zhang, Ruiying Chen, Lulu He, Qiming Wang, Han Wang, Yue Du, Ruijuan Liu, Chunmin Huang, Xiaojian Zhang, Yun-Gui Yang, Quancheng Kan, Xin Tian
Journal: Molecular Cancer (2023)

RNA 5-methylcytosine (m5C) modification plays critical roles in the pathogenesis of various tumors. However, the function and molecular mechanism of RNA m5C modification in tumor drug resistance remain unclear.The correlation between RNA m5C methylation, m5C writer NOP2/Sun RNA methyltransferase family member 2 (NSUN2) and EGFR-TKIs resistance was determined in non-small-cell lung cancer (NSCLC) cell lines and patient samples. The effects of NSUN2 on EGFR-TKIs resistance were investigated by gain- and loss-of-function assays in vitro and in vivo. RNA-sequencing (RNA-seq), RNA bisulfite sequencing (RNA-BisSeq) and m5C methylated RNA immunoprecipitation-qPCR (MeRIP-qPCR) were performed to identify the target gene of NSUN2 involved in EGFR-TKIs resistance. Furthermore, the regulatory mechanism of NSUN2 modulating the target gene expression was investigated by functional rescue and puromycin incorporation assays.RNA m5C hypermethylation and NSUN2 were significantly correlated with intrinsic resistance to EGFR-TKIs. Overexpression of NSUN2 resulted in gefitinib resistance and tumor recurrence, while genetic inhibition of NSUN2 led to tumor regression and overcame intrinsic resistance to gefitinib in vitro and in vivo. Integrated RNA-seq and m5C-BisSeq analyses identified quiescin sulfhydryl oxidase 1 (QSOX1) as a potential target of aberrant m5C modification. NSUN2 methylated QSOX1 coding sequence region, leading to enhanced QSOX1 translation through m5C reader Y-box binding protein 1 (YBX1).Our study reveals a critical function of aberrant RNA m5C modification via the NSUN2-YBX1-QSOX1 axis in mediating intrinsic resistance to gefitinib in EGFR-mutant NSCLC.
Reduced plasma cholesterol in Plasmodium falciparum infection: A meta-analysis
Authors: Yao You, Hua Fan, Shenghui Zhang, Siqi Hu, Jiake Tang, Chen Chen, Wen Wen, Chunyi Wang, Yongran Cheng, Mengyun Zhou, Zhanhui Feng, Tao Tan, Guanming Qi, Wenbin Zhao, Xingwei Zhang, Mingwei Wang, Lili Dai
Journal: Journal of Infection (2023)