POS1533-HPR COMPARISON OF HAND FUNCTIONS AND FUNCTIONAL STATUS IN PATIENTS WITH LIMITED CUTANEOUS SYSTEMIC SCLEROSIS AND DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS
Authors: E. A. Akatay, D. Bayraktar, E. Otman Akad, O. Ustun, İ. Kurut Aysin, D. C. Saraç, B. Atalay, I. Ramazanoglu, I. Tekin, T. Kurum, S. Gucenmez, M. Ozmen, S. Akar
Journal: Annals of the Rheumatic Diseases (2022)

Background Systemic Sclerosis (SSc) is an autoimmune connective tissue disorder which is characterised by the fibrotic changes in the skin effecting especially fingers and hands. Regarding skin manifestations, SSc is classified into two different subtypes as limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc). Objectives The aim of the present study was to compare hand functions and functional status in patients with lcSSc and dcSSc. Methods Twenty-three patients with lcSSc and thirteen patients with dcSSc were included in the study. Modified Hand Mobility in Scleroderma Test (mHAMIS), modified Rodnan skin score (mRSS), grip and pinch strengths were measured to evaluate hand-related physical characteristics. Duruoz Hand Index, Disability of Arm, Shoulder and Hand Questionnaire (DASH), Health Assessment Questionnaire (HAQ), and Scleroderma Health Assessment Questionnaire (SHAQ) were used as the outcomes. Results While differences were detected in mRSS scores between disease subtypes ( p &lt;0.05), hand functions and functional status were comparable between groups ( p &gt;0.05). Table 1. Comparison of the groups lcSSc Group Median (IQR 25/75) (n= 23) dcSSc Group Median (IQR 25/75) (n=13) p* mHAMIS (score 0-4) 0 (0/1) 0 (0/0) 0.745 mRSS Fingers (score 0-3) 2 (1.5/3) 3 (2/3) 0.100 mRSS Hands (score 0-3) 1 (0.5/2) 2 (2/3) 0.020* mRSS Forearms (score 0-3) 0 (0/1) 2 (1/2) 0.013* mRSS Upper Arms (score 0-3) 0 (0/0) 1 (0/1) 0.003* mRSS Total (0-51) 8 (5/13) 27 (18/29) 0.006* Hand Grip Strength (kg) 19.7 (11.2/24.6) 20.9 (14.4/24.8) 0.649 Tip to Tip Pinch Strength (kg) 3 (2.2/3.9) 3.3 (2.4/2.9) 0.721 Three Jaw Pinch Strength (kg) 2.4 (1.7/3.2) 2.8 (2/3.5) 0.226 Lateral Pinch Strength (kg) 3.8 (3.4/5.1) 4 (3.2/5.3) 0.948 Duruoz Hand Index (score 0-90) 5 (0/17) 6 (0/15) 0.770 DASH (score 30-150) 62 (47/84) 61 (53/77) 0.770 HAQ (score 0-3) 0.3 (0.1/0.9) 0.3 (0.8/0.9) 1.000 SHAQ-Raynaud’s Phenomenon (score 0-3) 0.8 (0/1.4) 1.3 (0.3/1.5) 0.363 SHAQ-Digital Ulcers (score 0-3) 0 (0/0.6) 0.3 (0/1.7) 0.136 SHAQ-Gastrointestinal (score 0-3) 0 (0/1.5) 0.7 (0.1/1.4) 0.466 SHAQ-Pulmonary (score 0-3) 0.5 (0/1.5) 1 (0.2/1.5) 0.534 SHAQ-Patient Global Assessment (score 0-3) 1.1 (0.1/2) 1.4 (0.8/2.2) 0.345 p&lt;0.05, *: Mann-Whitney U test, IQR 25/75: Interquartile range between the 25 th and 75 th percentiles, n: number, mHAMIS: modified Hand Mobility in Scleroderma Test, mRSS: modified Rodnan skin score, DASH: Disability of Arm, Shoulder, and Hand Questionnaire, HAQ: Health Assessment Questionnaire, SHAQ: Scleroderma Health Assessment Questionnaire, lcSSc: limited cutaneous Systemic Sclerosis, dcSSc: diffuse cutaneous Systemic Sclerosis Conclusion According to our results, even though, patients with dcSSc present higher skin thickening compared to patients with lcSSc, hand functions and functional status seem to be similar between SSc subtypes. Disclosure of Interests None declared