tbuckley/cabot-search huggingface dataset:
Body image and treatment desires at clinical entry in non-binary and genderqueer adults
Authors: Bodi Huisman, Anouk Verveen, Nastasja M. de Graaf, Thomas D. Steensma, Baudewijntje P. C. Kreukels
Journal: International Journal of Transgender Health (2022)

Background: Gender clinics are experiencing an increase in non-binary and/or genderqueer (NBGQ) individuals applying for gender affirming medical treatment (GAMT). GAMT is a well-established approach in reducing body dissatisfaction in binary transgender (BT) people, but knowledge on GAMT in NBGQ people is limited. Previous research shows that NBGQ individuals report different treatment needs compared to BT individuals. In attempting to address this difference, the current study examines the association between identifying as NBGQ, body dissatisfaction and their underlying motives for GAMT. The main research objectives were to describe the desires and motives for GAMT in NBGQ people and to examine how body dissatisfaction and gender identity relate to one's request for GAMT. Methods: Online self-report questionnaires were administered on 850 adults referred to a gender identity clinic (Mdn age = 23.9 years). Gender identity and desires for GAMT were surveyed at clinical entry. Body satisfaction was assessed with the Body Image Scale (BIS). Multiple linear regressions were used to examine whether BIS scores differed between NBGQ and BT individuals. Chi-square post hoc analyses were used to identify differences in treatment desires and motives between BT and NBGQ individuals. Logistic regressions were conducted to study the association between body image, gender identity and treatment desire. Results: Compared to BT persons (n = 729), NBGQ persons (n = 121) reported less body dissatisfaction, primarily with the genital area. NBGQ persons also preferred fewer GAMT interventions. If a procedure was not desired, NBGQ individuals more often motivated this on the basis of their gender identity, while BT individuals more often cited the risks of the procedure as their primary reason. The study confirms the need for more NBGQ specialized care, as they have a distinct experience of their gender incongruence, physical distress and express specific needs in GAMT.
Response to Comment on Lontchi-Yimagou et al. An Atypical Form of Diabetes Among Individuals With Low BMI. Diabetes Care 2022;45:1428–1437
Authors: Eric Lontchi-Yimagou, Shajith Anoop, Mathews Edatharayil Kurian, Kenny Ye, Sylvia Kehlenbrink, Nihal Thomas, Meredith Hawkins
Journal: Diabetes Care (2022)
Response to Comment on Marcoux et al. Varying Impact of Gestational Diabetes Mellitus on Incidence of Childhood Cancers: An Age-Stratified Retrospective Cohort Study. Diabetes Care 2022;45:1177–1183
Authors: Gabriel Côté-Corriveau, Sophie Marcoux, Valérie Leduc, Jessica Healy-Profitós, Nathalie Auger
Journal: Diabetes Care (2022)
Comment on Lontchi-Yimagou et al. An Atypical Form of Diabetes Among Individuals With Low BMI. Diabetes Care 2022;45:1428–1437
Authors: Ranjit Unnikrishnan, Ranjit Mohan Anjana, Satinath Mukhopadhyay, Jothydev Kesavadev, Ambrish Mithal, Shashank Joshi, Banshi Saboo, Nikhil Tandon, Viswanathan Mohan
Journal: Diabetes Care (2022)
Underreporting of Major Cardiac Adverse Events With Immune Checkpoint Inhibitors in Clinical Trials: Importance of Postmarketing Pharmacovigilance Surveys
Authors: Pascale Palassin, Jean-Luc Faillie, Cyrille Coustal, Xavier Quantin, Delphine Topart, François Roubille, Alexandre T.J. Maria
Journal: Journal of Clinical Oncology (2022)

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Listeriosis outbreak caused by contaminated stuffed pork, Andalusia, Spain, July to October 2019
Authors: Nicolás Francisco Fernández-Martínez, Rafael Ruiz-Montero, Eduardo Briones, Elena Baños, Lucía García San Miguel Rodríguez-Alarcón, J Alberto Chaves, Raquel Abad, Carmen Varela, Nicola Lorusso
Journal: Eurosurveillance (2022)

Between 1 July and 26 October 2019 in Andalusia, Spain, a large outbreak with 207 confirmed cases of listeriosis was identified. Confirmed cases had a median age of 44 years (range: 0-94) and 114 were women (55.1%). Most cases (n = 154) had mild gastroenteritis, 141 (68.1%) required hospitalisation and three died; five of 34 pregnant women had a miscarriage. The median incubation period was 1 day (range: 0-30), and was significantly shorter in cases presenting with gastroenteritis compared to those presenting without gastroenteritis (1 day vs. 3 days, respectively, p value < 0.001). Stuffed pork, a ready-to-eat product consumed unheated, from a single producer contaminated with Listeria monocytogenes ST388 was identified as the source of infection. The outbreak strain was identified in 189 human samples and 87 non-human (82 food and 5 environmental) samples. Notification of new cases declined abruptly after control measures were implemented. These included contaminated food recall, protocols for clinical management of suspected cases and for post-exposure prophylaxis in pregnant women and communication campaigns with concise messages to the population through social media. Given that there were 3,059 probable cases, this was the largest L. monocytogenes outbreak ever reported in Europe.
Hematopoietic-specific melanocortin 1 receptor signaling protects against nephrotoxic serum nephritis and mediates the beneficial effect of melanocortin therapy
Authors: Xuejing Guan, Bohan Chen, Deepak K. Malhotra, Amira F. Gohara, Lance D. Dworkin, Rujun Gong
Journal: Kidney International (2022)
Surgical Results of Trabeculectomy among Groups Stratified by Prostaglandin-Associated Periorbitopathy Severity
Authors: Akiko Ishida, Takako Miki, Tomoko Naito, Sho Ichioka, Yuji Takayanagi, Masaki Tanito
Journal: Ophthalmology (2022)

To report the role of prostaglandin-associated periorbitopathy (PAP) severity in the surgical effectiveness of trabeculectomy (LEC).Retrospective observational case series.A total of 139 consecutive eyes of 139 Japanese subjects (74 men, 65 women; mean age ± standard deviation, 65.7 ± 10.6 years) who underwent LEC were included. All had primary open-angle glaucoma (POAG), no history of conjunctival incisional surgery, completed all postoperative visits for 12 months, and information on the PAP severity using the Shimane University PAP Grading System (SU-PAP).Data were collected from a medical chart review at 2 hospitals.Comparison of surgical success rates among groups stratified by SU-PAP grades 0 to 3 by survival curve analysis using the definitions of failure based on surgical intervention other than laser suture lysis (LSL), intraocular pressure (IOP) reduction below 20%, postoperative IOP exceeding 15 mmHg (definition A) or 12 mmHg (definition B), and a postoperative IOP below 6 mmHg.Twelve months postoperatively, the success rates of grades 0, 1, 2, and 3 were 86%, 68%, 40%, and 0%, respectively, for definition A (P < 0.0001, log-rank test) and 86%, 61%, 36%, and 0%, respectively, for definition B (P < 0.0001). Interventions other than LSL (P < 0.0001, Cochran-Armitage trend test), IOP reduction less than 20% (P = 0.010), and IOP exceeding 15 mmHg (P = 0.016) or 12 mmHg (P < 0.0001) were associated with surgical failure; IOP under 6 mmHg was not (P = 0.31). The proportional hazard model for definition A showed that compared with grade 0, grade 2 (risk ratio [RR], 5.82, P = 0.0043) and grade 3 (RR, 12.2, P = 0.0003) were associated with surgical failure. For definition B, grade 1 (RR, 3.53, P = 0.040), grade 2 (RR, 6.65, P = 0.0021), and grade 3 (RR, 12.0, P = 0.0003) were associated with surgical failure. Differences in age, gender, preoperative IOP and medications, refractive error, and simultaneous cataract surgery were not associated with surgical failure in both models.The preoperative presence of severe PAP worsens the 1-year success rate of LEC in patients with POAG. To retain the surgical effectiveness, treating physicians should prevent patients from progressing to severe PAP, an avoidable side effect, by switching or stopping the causative medications.Proprietary or commercial disclosure may be found after the references.
Effectiveness of Microinvasive Glaucoma Surgery in the United States
Authors: Shuang-An Yang, Elizabeth C. Ciociola, William Mitchell, Nathan Hall, Alice C. Lorch, Joan W. Miller, David S. Friedman, Michael V. Boland, Tobias Elze, Nazlee Zebardast, Suzann Pershing, Leslie Hyman, Julia A. Haller, Aaron Y. Lee, None Lee, Flora Lum, Joan W. Miller, Alice Lorch
Journal: Ophthalmology (2022)
MET alterations in NSCLC—Current Perspectives and Future Challenges
Authors: Jordi Remon, Lizza E.L. Hendriks, Giannis Mountzios, Rosario García-Campelo, Stephanie P.L. Saw, Dipesh Uprety, Gonzalo Recondo, Guillermo Villacampa, Martin Reck
Journal: Journal of Thoracic Oncology (2022)
Therapeutic role of ursodeoxycholic acid in colitis-associated cancer via gut microbiota modulation
Authors: Qilang He, Jinjie Wu, Jia Ke, Qiang Zhang, Wanyi Zeng, Zhanhao Luo, Junli Gong, Yuan Chen, Zhen He, Ping Lan
Journal: Molecular Therapy (2022)

Inflammatory bowel disease (IBD) is a predisposing factor for colitis-associated cancer (CAC). The association between bile acids and the gut microbiota has been demonstrated in colon neoplasia; however, the effect of ursodeoxycholic acid (UDCA) on gut microbiota alteration in development of colitis and CAC is unknown. Our analysis of publicly available datasets demonstrated the association of UDCA treatment and accumulation of Akkermansia. UDCA-mediated alleviation of DSS-induced colitis was microbially dependent. UDCA treatment significantly upregulated Akkermansia colonization in a mouse model. Colonization of Akkermansia was associated with enhancement of the mucus layer upon UDCA treatment as well as activation of bile acid receptors in macrophages. UDCA played a role in CAC prevention and treatment in the AOM-DSS and Apc
First-Line Nivolumab Plus Ipilimumab With Chemotherapy Versus Chemotherapy Alone for Metastatic NSCLC in CheckMate 9LA: 3-Year Clinical Update and Outcomes in Patients With Brain Metastases or Select Somatic Mutations
Authors: Luis G. Paz-Ares, Tudor-Eliade Ciuleanu, Manuel Cobo, Jaafar Bennouna, Michael Schenker, Ying Cheng, Oscar Juan-Vidal, Hideaki Mizutani, Alejo Lingua, Felipe Reyes-Cosmelli, Niels Reinmuth, Juliana Menezes, Jacek Jassem, Svetlana Protsenko, Eduardo Richardet, Enriqueta Felip, Kynan Feeney, Bogdan Zurawski, Aurelia Alexandru, Emmanuel de la Mora Jimenez, Shaker Dakhil, Shun Lu, Martin Reck, Thomas John, Nan Hu, Xiaoqing Zhang, Judi Sylvester, Laura J. Eccles, Diederik J. Grootendorst, David Balli, Jaclyn Neely, David P. Carbone
Journal: Journal of Thoracic Oncology (2022)

<h2>Abstract</h2><h3>Introduction</h3> In the phase 3 CheckMate 9LA study, nivolumab plus ipilimumab with chemotherapy prolonged overall survival (OS) versus chemotherapy alone. We report updated efficacy/safety (≥3 years' follow-up), clinical outcomes in patients with baseline brain metastases, and exploratory somatic mutation analyses. <h3>Methods</h3> Adults with stage IV/recurrent non–small cell lung cancer (NSCLC), no known sensitizing <i>EGFR</i>/<i>ALK</i> alterations, and Eastern Cooperative Oncology Group performance status ≤1 were randomized 1:1 to nivolumab 360 mg every 3 weeks plus ipilimumab 1 mg/kg every 6 weeks with chemotherapy (2 cycles), or chemotherapy alone (4 cycles). Assessments included OS, progression-free survival (PFS), and objective response rate. Exploratory analyses included systemic/intracranial efficacy in patients with or without baseline brain metastases, in addition to OS and PFS by <i>KRAS</i>, <i>TP53</i>, <i>STK11</i>, and <i>KEAP1</i> somatic mutation status in patients with non-squamous NSCLC. <h3>Results</h3> With a minimum follow-up of 36.1 months, nivolumab plus ipilimumab with chemotherapy continued to prolong OS versus chemotherapy alone in the intent-to-treat population (median [HR; 95% CI] OS: 15.8 versus 11.0 months [0.74; 0.62–0.87]; 3-year OS: 27% versus 19%). Efficacy outcomes were improved in patients with pretreated baseline brain metastases (median [HR; 95% CI] OS: 19.3 versus 6.8 months [0.45; 0.29–0.70]; systemic PFS: 9.7 versus 4.1 months [0.44; 0.28–0.69]; intracranial PFS: 11.4 versus 4.6 months [0.42; 0.26–0.68]). A trend of OS benefit was observed in patients treated with nivolumab plus ipilimumab with chemotherapy versus chemotherapy alone, despite <i>KRAS</i>, <i>TP53,</i> and <i>STK11</i> tumor mutations. Extended follow-up revealed no new safety signals. <h3>Conclusions</h3> With a 3-year minimum follow-up, nivolumab plus ipilimumab with 2 cycles of chemotherapy continued to demonstrate long-term, durable efficacy versus chemotherapy alone; manageable safety profile; and survival benefit in patients with or without baseline brain metastases or select somatic mutations, further supporting the regimen as first-line treatment for patients with metastatic NSCLC.
The TNM System Is Not Adequate to Guide Lung Cancer Multidisciplinary Teams in Treatment Decisions in the Precision Oncology Era
Authors: Fieke Hoeijmakers, Wilhelmina H. Schreurs, Emile F.I. Comans, José S.A. Belderbos, Pieter E. Postmus, Rob A.E. M. Tollenaar, David J. Heineman
Journal: Journal of Thoracic Oncology (2022)
Safety and efficacy of the oral TLR8 agonist selgantolimod in individuals with chronic hepatitis B under viral suppression
Authors: Edward J. Gane, P. Rod Dunbar, Anna E. Brooks, Fangqiu Zhang, Diana Chen, Jeffrey J. Wallin, Nicholas van Buuren, Priyanka Arora, Simon P. Fletcher, Susanna K. Tan, Jenny C. Yang, Anuj Gaggar, Shyamasundaran Kottilil, Lydia Tang
Journal: Journal of Hepatology (2022)
Diagnostic Performance of Noninvasive Tests for Advanced Hepatic Fibrosis in Young Age Population
Authors: Mimi Kim, Eileen Laurel Yoon, Jonghyun Lee, Seon Cho, Chul-Min Lee, Bo Kyeong Kang, Huiyul Park, Dae Won Jun, Eun-Hee Nah
Journal: Clinical Gastroenterology and Hepatology (2022)
The 2022 China report of the Lancet Countdown on health and climate change: leveraging climate actions for healthy ageing
Authors: Wenjia Cai, Chi Zhang, Shihui Zhang, Yuqi Bai, Max Callaghan, Nan Chang, Bin Chen, Huiqi Chen, Liangliang Cheng, Xueqin Cui, Hancheng Dai, Bawuerjiang Danna, Wenxuan Dong, Weicheng Fan, Xiaoyi Fang, Tong Gao, Yang Geng, Dabo Guan, Yixin Hu, Junyi Hua, Cunrui Huang, Hong Huang, Jianbin Huang, Linlang Jiang, Qiaolei Jiang, Xiaopeng Jiang, Hu Jin, Gregor Kiesewetter, Lu Liang, Borong Lin, Hualiang Lin, Huan Liu, Qiyong Liu, Tao Liu, Xiaobo Liu, Xinyuan Liu, Zhao Liu, Zhu Liu, Shuhan Lou, Chenxi Lu, Zhenyu Luo, Wenjun Meng, Hui Miao, Chao Ren, Marina Romanello, Wolfgang Schöpp, Jing Su, Xu Tang, Can Wang, Qiong Wang, Laura Warnecke, Sanmei Wen, Wilfried Winiwarter, Yang Xie, Bing Xu, Yu Yan, Xiu Yang, Fanghong Yao, Le Yu, Jiacan Yuan, Yiping Zeng, Jing Zhang, Lu Zhang, Rui Zhang, Shangchen Zhang, Shaohui Zhang, Qi Zhao, Dashan Zheng, Hao Zhou, Jingbo Zhou, Margaret Fu-Chun Chan Fung, Yong Luo, Peng Gong
Journal: The Lancet Public Health (2022)

Pursuing a climate-resilient and carbonneutral transition will help to tackle these intertwined challenges.At a time of rapid population ageing, climate actions could be leveraged for healthy ageing, but this will require a fast and coordinated transition from all stakeholders.
A mould in the fold should never grow old: cutaneous aspergillosis in a preterm neonate
Authors: Cihan Papan, Martina Geipel, Solvej Heidtmann, Rachel Müller, Diana Praschmo, Clemens-Magnus Meier, Grit Walther, Oliver Kurzai, Andreas H. Groll, Michael Zemlin, Arne Simon
Journal: Clinical Microbiology and Infection (2022)
The need for better diagnostics to support diagnosis and surveillance in monkeypox endemic countries
Authors: Asma Khalil, Athina Samara, Pat O'Brien, Shamez Ladhani
Journal: The Lancet Microbe (2022)

We read with interest the Newsdesk piece of Vijay Shankar Balakrishnan1, discussing how the current monkeypox outbreak in non-endemic countries has brought forward the global need to upscale and improve monkeypox diagnostics.
Viral suppression and self-reported ART adherence after 3 years of universal testing and treatment in the HPTN 071 (PopART) community-randomised trial in Zambia and South Africa: a cross-sectional analysis
Authors: David Macleod, Kwame Shanaube, Timothy Skalland, Mohammed Limbada, Nomtha Mandla, Justin Bwalya, Ab Schaap, Blia Yang, Deborah Donnell, Estelle Piwowar-Manning, Susan H Eshleman, Graeme Hoddinott, Virginia Bond, Ayana Moore, Sam Griffith, Peter Bock, Helen Ayles, Sarah Fidler, Richard Hayes, Sian Floyd
Journal: The Lancet HIV (2022)
Vaccination and protective immunity to SARS-CoV-2 omicron variants in people with immunodeficiencies
Authors: Angalee Nadesalingam, Diego Cantoni, Ernest T Aguinam, Andrew CY Chan, Minna Paloniemi, Luis Ohlendorf, Charlotte George, George Carnell, Jon Lyall, Matteo Ferrari, Nigel Temperton, Ralf Wagner, Javier Castillo-Olivares, Helen Baxendale, Jonathan L Heeney
Journal: The Lancet Microbe (2022)

Despite the success of COVID-19 vaccination programmes in reducing morbidity and mortality, a substantial number of individuals in the general population respond poorly to SARS-CoV-2 vaccination.1,2 Furthermore, only about 20% of individuals throughout low-income countries have received their first dose of the SARS-CoV-2 vaccine.3 Neutralising antibodies are a key correlate to protection from COVID-19, with booster vaccines offered to increase protection from new variants.4,5 However, poor responsiveness to immunisation increases the risk of infection and disease.
Forced vital capacity trajectories in patients with idiopathic pulmonary fibrosis: a secondary analysis of a multicentre, prospective, observational cohort
Authors: Hernan P Fainberg, Justin M Oldham, Philip L Molyneaux, Richard J Allen, Luke M Kraven, William A Fahy, Joanne Porte, Rebecca Braybrooke, Gauri Saini, Morten A Karsdal, Diane J Leeming, Jannie M B Sand, Isaac Triguero, Eunice Oballa, Athol U Wells, Elisabetta Renzoni, Louise V Wain, Imre Noth, Toby M Maher, Iain D Stewart, R Gisli Jenkins
Journal: The Lancet Digital Health (2022)
Genetic and phenotypic stability of poliovirus shed from infants who received novel type 2 or Sabin type 2 oral poliovirus vaccines in Panama: an analysis of two clinical trials
Authors: Rahnuma Wahid, Laina D Mercer, Tirza De Leon, Rodrigo DeAntonio, Xavier Sáez-Llorens, Andrew Macadam, Konstantin Chumakov, Jeroen Strating, Björn Koel, Jennifer L Konopka-Anstadt, M Steven Oberste, Cara C Burns, Raul Andino, Erman Tritama, Ananda S Bandyopadhyay, Gabriela Aguirre, Ricardo Rüttimann, Chris Gast, John O Konz
Journal: The Lancet Microbe (2022)
Uncloaking cell-impermeant gold nanorods via tumor microenvironmental cathepsin B facilitates cancer cell penetration and potent radiosensitization
Authors: Subhiksha Raghuram, Yuri Mackeyev, Jessica Symons, Yasmin Zahra, Valeria Gonzalez, Krishnan K. Mahadevan, Katherinne I. Requejo, Anton Liopo, Paul Derry, Eugene Zubarev, Onur Sahin, Joseph Byung-Kyu Kim, Pankaj K. Singh, Sang Hyun Cho, Sunil Krishnan
Journal: Biomaterials (2022)
Ophthalmic Manifestations of ROSAH (Retinal Dystrophy, Optic Nerve Edema, Splenomegaly, Anhidrosis, and Headache) Syndrome, an Inherited NF κB–Mediated Autoinflammatory Disease with Retinal Dystrophy
Authors: Laryssa A. Huryn, Christina Torres Kozycki, Jasmine Y. Serpen, Wadih M. Zein, Ehsan Ullah, Alessandro Iannaccone, Lloyd B. Williams, Lucia Sobrin, Brian P. Brooks, H. Nida Sen, Robert B. Hufnagel, Daniel L. Kastner, Shilpa Kodati
Journal: Ophthalmology (2022)
The WHO AWaRe Antibiotic Book: providing guidance on optimal use and informing policy
Authors: Mike Sharland, Bernadette Cappello, Loice Achieng Ombajo, Joel Bazira, Ronald Chitatanga, Pem Chuki, Sumanth Gandra, Stephan Harbarth, Mark Loeb, Marc Mendelson, Lorenzo Moja, Celine Pulcini, Evelina Tacconelli, Veronica Zanichelli, Mei Zeng, Benedikt D Huttner
Journal: The Lancet Infectious Diseases (2022)
Inference of Gene Flow between Species under Misspecified Models
Authors: Jun Huang, Yuttapong Thawornwattana, Tomáš Flouri, James Mallet, Ziheng Yang
Journal: Molecular Biology and Evolution (2022)

Abstract Genomic sequence data provide a rich source of information about the history of species divergence and interspecific hybridization or introgression. Despite recent advances in genomics and statistical methods, it remains challenging to infer gene flow, and as a result, one may have to estimate introgression rates and times under misspecified models. Here we use mathematical analysis and computer simulation to examine estimation bias and issues of interpretation when the model of gene flow is misspecified in analysis of genomic datasets, for example, if introgression is assigned to the wrong lineages. In the case of two species, we establish a correspondence between the migration rate in the continuous migration model and the introgression probability in the introgression model. When gene flow occurs continuously through time but in the analysis is assumed to occur at a fixed time point, common evolutionary parameters such as species divergence times are surprisingly well estimated. However, the time of introgression tends to be estimated towards the recent end of the period of continuous gene flow. When introgression events are assigned incorrectly to the parental or daughter lineages, introgression times tend to collapse onto species divergence times, with introgression probabilities underestimated. Overall, our analyses suggest that the simple introgression model is useful for extracting information concerning between-specific gene flow and divergence even when the model may be misspecified. However, for reliable inference of gene flow it is important to include multiple samples per species, in particular, from hybridizing species.