tbuckley/cabot-search huggingface dataset:
Quantitative Tension on the Abdominal Wall in Posterior Components Separation With Transversus Abdominis Release
Authors: Benjamin T. Miller, Ryan C. Ellis, Clayton C. Petro, David M. Krpata, Ajita S. Prabhu, Lucas R. A. Beffa, Li-Ching Huang, Chao Tu, Michael J. Rosen
Journal: JAMA Surgery (2023)

Importance Posterior components separation (PCS) is a commonly used myofascial release technique in ventral hernia repairs. The contribution of each release with anterior and posterior fascial advancement has not yet been characterized in patients with ventral hernias. Objective To quantitatively assess the changes in tension on the anterior and posterior fascial elements of the abdominal wall during PCS to inform surgeons regarding the technical contribution of each step with those changes, which may help to guide intraoperative decision-making. Design, Setting, and Participants This case series enrolled patients from December 2, 2021, to August 2, 2022, and was conducted at the Cleveland Clinic Center for Abdominal Core Health. The participants included adult patients with European Hernia Society classification M1 to M5 ventral hernias undergoing abdominal wall reconstruction with PCS. Intervention A proprietary, sterilizable tensiometer measured the force needed to bring the fascial edge of the abdominal wall to the midline after each step of a PCS (retrorectus dissection, division of the posterior lamella of the internal oblique aponeurosis, and transversus abdominis muscle release [TAR]). Main Outcome The primary study outcome was the percentage change in tension on the anterior and posterior fascia associated with each step of PCS with TAR. Results The study included 100 patients (median [IQR] age, 60 [54-68] years; 52 [52%] male). The median (IQR) hernia width was 13.0 (10.0-15.2) cm. After complete PCS, the mean (SD) percentage changes in tension on the anterior and posterior fascia were −53.27% (0.53%) and −98.47% (0.08%), respectively. Of the total change in anterior fascial tension, retrorectus dissection was associated with a mean (SD) percentage change of −82.56% (0.68%), incision of the posterior lamella of the internal oblique with a change of −17.67% (0.41%), and TAR with no change. Of the total change in posterior fascial tension, retrorectus dissection was associated with a mean (SD) percentage change of −3.04% (2.42%), incision of the posterior lamella of the internal oblique with a change of −58.78% (0.39%), and TAR with a change of −38.17% (0.39%). Conclusions and Relevance In this case series, retrorectus dissection but not TAR was associated with reduced tension on the anterior fascia, suggesting that it should be performed if anterior fascial advancement is needed. Dividing the posterior lamella of the internal oblique aponeurosis and TAR was associated with reduced tension on the posterior fascia, suggesting that it should be performed for posterior fascial advancement.
LINC00922 decoys SIRT3 to facilitate the metastasis of colorectal cancer through up-regulation the H3K27 crotonylation of ETS1 promoter
Authors: Meijian Liao, Xiaolin Sun, Wendan Zheng, Mengdi Wu, Yifan Wang, Jia Yao, Yu Ma, Shoucui Gao, Dongsheng Pei
Journal: Molecular Cancer (2023)

Abstract Background Lysine crotonylation (Kcr) is up-regulation in colorectal cancer (CRC) tissues, while its specific contribution remains uncertain. This study aimed to elucidate the role and mechanism of crotonylation on Lys27 of histone H3 (H3K27cr) in facilitating CRC metastasis. Methods Immunohistochemistry was employed to investigate the correlation between H3K27cr and CRC metastasis. Both in vitro and in vivo assays employing loss function or gain function approaches were conducted to elucidate the role of LINC00922 in promoting CRC metastasis. ScRNA-seq analysis and immunoprecipitation analyses were employed to explore the underlying mechanism by which LINC00922 facilitates CRC metastasis through H3K27cr. Results Clinically, H3K27cr was upregulated in metastatic CRC tissues and positively correlated with advanced clinical stages. Functionally, knockdown of LINC00922 inhibited migration of CRC cells both in vitro and in vivo. Furthermore, the supplementation of NaCr restored the migration and invasion levels of LINC00922 stable knockdown cells by restoring the H3K27cr level. Mechanistically, LINC00922 promoted invasion and migration through H3K27cr mediated cell adhesion molecules (CAMs) in epithelial cells. Notably, LINC00922 interacted with the protein sirtuin 3 (SIRT3) and obstructed its binding to the promoter region of ETS1, leading to an elevation in the level of H3K27cr in this promoter region and the subsequent activation of ETS1 transcription. Conclusions Our findings uncovered a novel regulatory function of H3K27cr, regulated by LINC00922, in facilitating CRC metastasis. This discovery contributed to a deeper comprehension of the involvement of histone crotonylation in the metastatic process of CRC.
Individual-Level Risk Prediction of Return to Use During Opioid Use Disorder Treatment
Authors: Sean X. Luo, Daniel J. Feaster, Ying Liu, Raymond R. Balise, Mei-Chen Hu, Layla Bouzoubaa, Gabriel J. Odom, Laura Brandt, Yue Pan, Yih-Ing Hser, Paul VanVeldhuisen, Felipe Castillo, Anna R. Calderon, John Rotrosen, Andrew J. Saxon, Roger D. Weiss, Melanie Wall, Edward V. Nunes
Journal: JAMA Psychiatry (2023)

No existing model allows clinicians to predict whether patients might return to opioid use in the early stages of treatment for opioid use disorder.
Associations Between Rheumatoid Arthritis Clinical Factors and Synovial Cell Types and States
Authors: Dana Weisenfeld, Fan Zhang, Laura Donlin, Anna Helena Jonsson, William Apruzzese, Debbie Campbell, Deepak A. Rao, Kevin Wei, V. Michael Holers, Ellen Gravallese, Larry Moreland, Susan Goodman, Michael Brenner, Soumya Raychaudhuri, Andrew Filer, Jennifer Anolik, Vivian Bykerk, Katherine P. Liao
Journal: Arthritis & Rheumatology (2023)

Objective Recent studies have uncovered diverse cell types and states in the rheumatoid arthritis (RA) synovium; however, limited data exist correlating these findings with patient‐level clinical information. Using the largest cohort to date with clinical and multicell data, we determined associations between RA clinical factors with cell types and states in the RA synovium. Methods The Accelerated Medicines Partnership Rheumatoid Arthritis study recruited patients with active RA who were not receiving disease‐modifying antirheumatic drugs (DMARDs) or who had an inadequate response to methotrexate (MTX) or tumor necrosis factor inhibitors. RA clinical factors were systematically collected. Biopsies were performed on an inflamed joint, and tissue were disaggregated and processed with a cellular indexing of transcriptomes and epitopes sequencing pipeline from which the following cell type percentages and cell type abundance phenotypes (CTAPs) were derived: endothelial, fibroblast, and myeloid (EFM); fibroblasts; myeloid; T and B cells; T cells and fibroblasts (TF); and T and myeloid cells. Correlations were measured between RA clinical factors, cell type percentage, and CTAPs. Results We studied 72 patients (mean age 57 years, 75% women, 83% seropositive, mean RA duration 6.6 years, mean Disease Activity Score‐28 C‐reactive Protein 3 [DAS28‐CRP3] score 4.8). Higher DAS28‐CRP3 correlated with a higher T cell percentage ( P &lt; 0.01). Those receiving MTX and not a biologic DMARD (bDMARD) had a higher percentage of B cells versus those receiving no DMARDs ( P &lt; 0.01). Most of those receiving bDMARDs were categorized as EFM (57%), whereas none were TF. No significant difference was observed across CTAPs for age, sex, RA disease duration, or DAS28‐CRP3. Conclusion In this comprehensive screen of clinical factors, we observed differential associations between DMARDs and cell phenotypes, suggesting that RA therapies, more than other clinical factors, may impact cell type/state in the synovium and ultimately influence response to subsequent therapies.
Online Well-Being Group Coaching Program for Women Physician Trainees
Authors: Adrienne Mann, Ami N. Shah, Pari Shah Thibodeau, Liselotte Dyrbye, Adnan Syed, Maria A. Woodward, Kerri Thurmon, Christine D. Jones, Kimiko S. Dunbar, Tyra Fainstad
Journal: JAMA Network Open (2023)

Physician burnout disproportionately affects women physicians and begins in training. Professional coaching may improve well-being, but generalizable evidence is lacking.
Disciplining the disciplined: Making sense of the gender gap that lies at the core of puritanical morals
Authors: Edward B. Royzman, Samuel H. Borislow
Journal: Behavioral and Brain Sciences (2023)

Abstract Because suppression of sex has been and is at the core of puritanical morals, a proper account thereof would need to explain why suppression of sex has been largely directed towards the human female. Not only do the authors not account for this pattern, but their general model would seem to predict the reverse – that is, greater suppression/control of the male libido.
The evolution of puritanical morality has not always served to strengthen cooperation, but to reinforce male dominance and exclude women
Authors: Konrad Szocik
Journal: Behavioral and Brain Sciences (2023)

Abstract Puritanical morality regulates a range of seemingly insignificant behaviors, including those involving human sexuality. A sizable portion of the latter particularly burdens women, who are held responsible for the moral conduct of men. In my paper, I show that these norms have not necessarily served to evolve cooperation, but to subjugate and eliminate women from public life.
How to Reduce Worldwide Cancer Inequities for Women
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Woman in Her 50s With an Intravenous Mass Extending to the Right Cardiac Chamber
Authors: Jiehua Li, Quanming Li, Chang Shu
Journal: JAMA Cardiology (2023)

This case report describes a diagnosis of intravenous leiomyomatosis in a woman in her 50s who presented with exertional dyspnea and syncope and had a history of hysteromyomectomy.
Trial Launches of New HIV Vaccine Candidate With CMV Vector
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
US Obesity Prevalence Surged Over the Past Decade
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Combined Arterial and Venous Lower Extremity Injury
Authors: Areg Grigorian, Nii-Kabu Kabutey, Christian de Virgilio, Michael Lekawa, Sebastian Schubl, Matthew Martin, Jeffry Nahmias
Journal: JAMA Surgery (2023)

This case-control study assesses the need for prophylactic fasciotomy and delayed fasciotomy in combined arterial and venous injury compared with those with isolated artery or vein injury.
Drinking and feasting are perceived as facilitating cooperation
Authors: Yuhan Fu, Gerardo Viera
Journal: Behavioral and Brain Sciences (2023)

We argue that the occurrence of puritanical norms cannot simply be explained by appealing to the need for cooperation. Anthropological and archaeological studies suggest that across history and cultures' self-indulgent behaviours, such as excessive drinking, eating, and feasting, have been used to enhance cooperation by enforcing social and group identities.
Evolutionary research confirms that a need for collective action increases puritanism
Authors: Agner Fog
Journal: Behavioral and Brain Sciences (2023)

Abstract Recent findings in evolutionary psychology explain how moral disciplining is connected to the need for collective action. Morals are strict in societies affected by war or perceived collective danger, but loose where peace and security prevail. This theory supplements the moral disciplining theory by providing an evolutionary explanation for the postulated link between puritanism and the need for cooperation.
NKG2A Is a Therapeutic Vulnerability in Immunotherapy Resistant MHC-I Heterogeneous Triple-Negative Breast Cancer
Authors: Brandie C. Taylor, Xiaopeng Sun, Paula I. Gonzalez-Ericsson, Violeta Sanchez, Melinda E. Sanders, Elizabeth C. Wescott, Susan R. Opalenik, Ann Hanna, Shu-Ting Chou, Luc Van Kaer, Henry Gomez, Claudine Isaacs, Tarah J. Ballinger, Cesar A. Santa-Maria, Payal D. Shah, Elizabeth C. Dees, Brian D. Lehmann, Vandana G. Abramson, Jennifer A. Pietenpol, Justin M. Balko
Journal: Cancer Discovery (2023)

Abstract Despite the success of immune checkpoint inhibition (ICI) in treating cancer, patients with triple-negative breast cancer (TNBC) often develop resistance to therapy, and the underlying mechanisms are unclear. MHC-I expression is essential for antigen presentation and T-cell–directed immunotherapy responses. This study demonstrates that TNBC patients display intratumor heterogeneity in regional MHC-I expression. In murine models, loss of MHC-I negates antitumor immunity and ICI response, whereas intratumor MHC-I heterogeneity leads to increased infiltration of natural killer (NK) cells in an IFNγ-dependent manner. Using spatial technologies, MHC-I heterogeneity is associated with clinical resistance to anti-programmed death (PD) L1 therapy and increased NK:T-cell ratios in human breast tumors. MHC-I heterogeneous tumors require NKG2A to suppress NK-cell function. Combining anti-NKG2A and anti–PD-L1 therapies restores complete response in heterogeneous MHC-I murine models, dependent on the presence of activated, tumor-infiltrating NK and CD8+ T cells. These results suggest that similar strategies may enhance patient benefit in clinical trials. Significance: Clinical resistance to immunotherapy is common in breast cancer, and many patients will likely require combination therapy to maximize immunotherapeutic benefit. This study demonstrates that heterogeneous MHC-I expression drives resistance to anti–PD-L1 therapy and exposes NKG2A on NK cells as a target to overcome resistance. This article is featured in Selected Articles from This Issue, p. 201
Genomic Signatures Associated with Transitions to Viviparity in Cyprinodontiformes
Authors: Leeban H Yusuf, Yolitzi Saldívar Lemus, Peter Thorpe, Constantino Macías Garcia, Michael G Ritchie
Journal: Molecular Biology and Evolution (2023)

The transition from oviparity to viviparity has occurred independently over 150 times across vertebrates, presenting one of the most compelling cases of phenotypic convergence. However, whether the repeated, independent evolution of viviparity is driven by redeployment of similar genetic mechanisms and whether these leave a common signature in genomic divergence remains largely unknown. Although recent investigations into the evolution of viviparity have demonstrated striking similarity among the genes and molecular pathways involved across disparate vertebrate groups, quantitative tests for genome-wide convergent have provided ambivalent answers. Here, we investigate the potential role of molecular convergence during independent transitions to viviparity across an order of ray-finned freshwater fish (Cyprinodontiformes). We assembled de novo genomes and utilized publicly available genomes of viviparous and oviparous species to test for molecular convergence across both coding and noncoding regions. We found no evidence for an excess of molecular convergence in amino acid substitutions and in rates of sequence divergence, implying independent genetic changes are associated with these transitions. However, both statistical power and biological confounds could constrain our ability to detect significant correlated evolution. We therefore identified candidate genes with potential signatures of molecular convergence in viviparous Cyprinodontiformes lineages. Motif enrichment and gene ontology analyses suggest transcriptional changes associated with early morphogenesis, brain development, and immunity occurred alongside the evolution of viviparity. Overall, however, our findings indicate that independent transitions to viviparity in these fish are not strongly associated with an excess of molecular convergence, but a few genes show convincing evidence of convergent evolution.
Puritanism as moral advertisement helps solve the puzzle of ineffective moralization
Authors: Stefaan Blancke
Journal: Behavioral and Brain Sciences (2023)

Abstract The moral disciplining theory proposes that people moralize excessive innocent behavior to discipline others to behave in ways that facilitate cooperation. However, such disciplining might not always be effective. To solve this puzzle of ineffective moralization we should think of puritanism in terms of moral advertisement aimed at reputation management rather than the manipulation of others.
Is undisciplined behavior antithetical to cooperation, or is it part and parcel of it?
Authors: Kristen L Syme
Journal: Behavioral and Brain Sciences (2023)

Abstract This commentary raises three points in response to the target article. First, what appear to be victimless behaviors in highly individualistic, post-industrial societies might have a direct impact on group members in small-scale societies. Second, many societies show marked tolerance or ambivalence toward intemperate behavior. Third, undisciplined behavior is not antithetical to cooperation but can be used to cooperative ends.
Stroma-Mediated Breast Cancer Cell Proliferation Indirectly Drives Chemoresistance by Accelerating Tumor Recovery between Chemotherapy Cycles
Authors: Daria Miroshnychenko, Tatiana Miti, Pragya Kumar, Anna Miller, Mark Laurie, Nathalia Giraldo, Marilyn M. Bui, Philipp M. Altrock, David Basanta, Andriy Marusyk
Journal: Cancer Research (2023)

Abstract The ability of tumors to survive therapy reflects both cell-intrinsic and microenvironmental mechanisms. Across many cancers, including triple-negative breast cancer (TNBC), a high stroma/tumor ratio correlates with poor survival. In many contexts, this correlation can be explained by the direct reduction of therapy sensitivity induced by stroma-produced paracrine factors. We sought to explore whether this direct effect contributes to the link between stroma and poor responses to chemotherapies. In vitro studies with panels of TNBC cell line models and stromal isolates failed to detect a direct modulation of chemoresistance. At the same time, consistent with prior studies, fibroblast-produced secreted factors stimulated treatment-independent enhancement of tumor cell proliferation. Spatial analyses indicated that proximity to stroma is often associated with enhanced tumor cell proliferation in vivo. These observations suggested an indirect link between stroma and chemoresistance, where stroma-augmented proliferation potentiates the recovery of residual tumors between chemotherapy cycles. To evaluate this hypothesis, a spatial agent–based model of stroma impact on proliferation/death dynamics was developed that was quantitatively parameterized using inferences from histologic analyses and experimental studies. The model demonstrated that the observed enhancement of tumor cell proliferation within stroma-proximal niches could enable tumors to avoid elimination over multiple chemotherapy cycles. Therefore, this study supports the existence of an indirect mechanism of environment-mediated chemoresistance that might contribute to the negative correlation between stromal content and poor therapy outcomes. Significance: Integration of experimental research with mathematical modeling reveals an indirect microenvironmental chemoresistance mechanism by which stromal cells stimulate breast cancer cell proliferation and highlights the importance of consideration of proliferation/death dynamics. See related commentary by Wall and Echeverria, p. 3667
There are no beautiful surfaces without a terrible depth
Authors: Joshua M. Tybur, Debra Lieberman
Journal: Behavioral and Brain Sciences (2023)

Abstract Fitouchi et al. persuasively argue against popular disgust-based accounts of puritanical morality. However, they do not consider alternative account of moral condemnation that is also based on the psychology of disgust. We argue that these other disgust-based accounts are more promising than those dismissed in the target article.
Puritanical moral rules as moral heuristics coping with uncertainties
Authors: Rasim Serdar Kurdoglu
Journal: Behavioral and Brain Sciences (2023)

Abstract As the cultural evolution of a puritanical moral norm in Turkey illustrates, puritanical moral norms are not developed by nonrational reasoning concerned with purity and cleanliness. People use puritanical moral rules as moral heuristics for making intendedly rational decisions about whether to cooperate or not when the commitment of the counterparty is uncertain.