tbuckley/cabot-search huggingface dataset:
Surgery's relevance to an understanding of basic biology. Tissue repair and cellular regeneration
Authors: J. E. Dunphy
Journal: JAMA (1967)

When J. D. Watson received the Nobel Prize in medicine in 1962, a prize which he shared with Francis Crick and Maurice Wilkins, he demonstrated in his lecture at Stockholm that the synthesis of protein<sup>1</sup>required the ordered interaction of deoxyribonucleic acid and at least three types of functional ribonucleic acid. In the introduction he tells of the anxieties and concerns which he and Crick felt when they were first trying to elucidate the structure of DNA. He wrote, During the next eighteen months, until the structure became elucidated, we frequently discussed the necessity that the correct structure have a capacity for replication and, in pessimistic moods we often worried that the structure might be dull, that it would suggest absolutely nothing and excite us no more than something inert, like collagen. Watson's view of collagen is illustrative of the powerful vision of a great mind finding a new
Efflux of Reduced Glutathione after Exposure of Human Lung Epithelial Cells to Crocidolite Asbestos
Authors: Scott A. Golladay, Sun-Hee Park, Ann E. Aust
Journal: Environmental Health Perspectives (1997)

This study investigated glutathione (GSH) homeostasis in human lung epithelial cells (A549) exposed to crocidolite.Exposure of A549 cells to 3 pg/cm2 crocidolite resulted in a decrease in intracellular reduced glutathione by 36% without a corresponding increase in GSH disulfide.After a 24-hr exposure to crocidolite, 75% of the intracellular GSH lost was recovered in the extracellular medium, of which 50% was in reduced form.Since the half-life of reduced GSH in culture medium was less than 1 hr, this suggests that reduced GSH was released continuously from the cells after treatment.The release of GSH did not appear to result from nonspecific membrane damage, as there was no concomitant release of lactate dehydrogenase or 14C-adenine from loaded cells after crocidolite treatment for 24 hr.Crocidolite exposure resulted in the formation of S-nitrosothiols but no increase in the level of GSH-protein mixed disulfides or GSH conjugates.Exposure of A549 cells to crocidolite for 24 hr decreased gamma glutamylcysteine synthetase (-GCS) activity by 47% without changes in the activities of GSH reductase, GSH peroxidase, GSH S-transferase, or glucose-6-phosphate dehydrogenase.Treatment of cells with crocidolite pretreated with the iron chelator desferrioxamine B resulted in the same level of intracellular GSH depletion and efflux and the same decrease in -tGCS activity as treatment with unmodified crocidolite, which suggests that iron-catalyzed reactions were not responsible for the GSH depletion.
The Metastatic Breast Cancer Project: A national direct-to-patient initiative to accelerate genomics research.
Authors: Nikhil Wagle, Corrie Painter, Max Krevalin, Coyin Oh, Kristin Anderka, Katie Larkin, Niall Lennon, Deborah Dillon, Elizabeth Frank, Eric P. Winer, Eric Lander, Todd Golub
Journal: Journal of Clinical Oncology (2016)

LBA1519 The full, final text of this abstract will be available at abstracts.asco.org at 7:30 AM (EDT) on Saturday, June 4, 2016, and in the Annual Meeting Proceedings online supplement to the June 20, 2016, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Monday edition of ASCO Daily News.
Liaison Psychiatry
Authors: Norman B. Levy
Journal: JAMA (1988)

For those unfamiliar with the term, "liaison psychiatry" refers to the outreach connections that psychiatry establishes with other medical specialties. It is generally carried out by psychiatrists who consult on patients who are physically sick and make rounds with or attend the conferences of various specialties. <i>Liaison Psychiatry</i>is comprehensive and attempts to cover the broadest range of the subject. Its author undertakes a discussion of virtually every organ system and multiorgan diseases and syndromes such as pain and terminal illness, the psychopharmacology of the physically sick, therapy strategies, and how one takes a history and does a mental status examination. There is a comprehensive overview with a 24-item list of "What the Liaison Psychiatrist Can and Should Do." An aspect of the book that deserves mention is the tone. The author seems not greatly compromised by doubts and tends to be very definitive in her conclusions. In this way,
Reconstruction of the Subclavian Artery for Complications of Cervical-Rib and Thoracic Outlet Syndrome
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Ultrasounding the heart.
Journal: BMJ (1974)

Ultrasounding the HeartDespite a slow start after its introduction in 1954 by I. Edler and C. H. Hertz' echocardiography has developed rapidly over the last five years.It is still of increasing importance in cardiac diagnosis.Echocardiography causes no discomfort and needs little co-operation from the patient, so it is suitable even on young children and infants.No ionizing irradiation is used, and the pulsed ultrasound beam exposes the patient to no hazard.It has steadily gained in precision both through technical advances and through having been checked against data obtained from catheterization, angiocardiography, and surgery.The echocardiogram (U.C.G.) is now highly reliable in the recognition and description of many forms of valve disease2-5 and is rapidly gaining ground in the diagnosis of congenital heart disease.6 8 Though weaker in quantitative assessment,
Overview: pseudodementia
Authors: T W McAllister
Journal: American Journal of Psychiatry (1983)

Despite the increased attention that the syndrome of pseudodementia is receiving, several important questions regarding diagnostic criteria and accuracy, etiology, and even the appropriateness of the term itself remain unanswered. The author reviews the literature on this topic, including published case reports. On the basis of the available data, it appears that there may be at least two categories of pseudodementia and that the cognitive impairment associated with depressive illness is more appropriately viewed as a depression-induced organic mental disorder. Directions for future research are suggested.
DIPHTHERIA.
Authors: W. H. SEIBERT
Journal: JAMA (1896)

Diphtheria is an acute infectious disease, which, primarily, affects the mucous membrane of the pharynx, larynx, or air-passages; and, secondarily, as result of the absorption of the toxic element from the seat of infection, a general systemic or constitutional disturbance arises. The history of this disease dates back over many centuries, apparently beyond the time of Hippocrates, and all nations seem to have been scourged with its various epidemics at one time or other. It is notable that various theories were advanced to explain its causation, but it was only during the latter part of the present century, when with the improved teaching of the microscope and the advanced detail of laboratory technique, that the real cause was discovered and identified, namely, the Loeffler bacillus. <h3>INCUBATION.</h3> The period of incubation is the time which elapses from the deposit of the bacillus or germ on the mucous membrane, until some morbid
Starving children.
Journal: BMJ (1968)

PointersLung Transplantation: Forced diuresis preceded lung transplantation as part of treatment of a 15year-old boy who accidentally swallowed a mouthful of undiluted paraquat.Urinary ex- cretion of paraquat fell rapidly daily, but death ensued.At necropsy transplanted lung showed changes attributable to paraquat but none to rejection (p.759).Leader at p. 755.Nephrectomy for Hypertension: When diseased kidney contributes less than 25% to renal func- tion and the contralateral kidney is intact, nephrectomy is recommended, particularly in young patients with significant hypertension (p.764).Leader at p. 754.Strokes in India: Angiographic findings in patients from west central India showed throm- bosis with atherosclerosis to be main cause of non-embolic cerebral infarction.The relative incidence of various cerebral vascular lesions did not differ significantly from that in Westerners (p. 769).House Dust Allergy: In a controlled trial of the treatment of asthma, injections of house dust extract gave no advantage to those sensitive to the dust (p.774).Mood and the "Pill": Highest incidence of depression and loss of libido occurred with strongly progestogenic compounds, which have high monoamine oxidase activity (p.777).Shunts for Dialysis: Evidence of circulatory overload in three patients who had Brescia-Cimino shunts for intermittent dialysis (p.781).New Plasma Expander: Intravenous 6% hydroxyethyl starch solution produced no adverse effects in 29 patients (p.783).Case Reports: Duodenal haematoma (p.785) cytomegalovirus disease as hepatitis (p.786).Common Skin Infections: Review of their man- agement (p.787).Progressive Care: Successful experiment described in which wards were arranged to allow free interchange of patients according to their nursing requirements (p.794).Congenital Defects: Importance of initial sym- pathetic counselling for the mothers of mal- formed or stillborn infants (p.796).Influenza: This winter's prospects (p.757).New Appliances: For urethrography (p.798) and whole-body plethysmography (p.799).
REPLY
Authors: A. Seaton
Journal: Thorax (1978)

Asthma-contrasts in care Sir,-I congratulate you on the new appearance and new plans for Thorax.I look forward both to signed leaders and to signed correspondence.I have one criticism to make of the otherwise admirable and important leader that you wrote on "Asthma-contrasts in care" (February 1978).You refer to "epidemiologists, who have successfully publicised the dubious toxicity of our most useful remedies without pointing out the therapeutic alter- natives."This is a serious accusation to make of professional colleagues and you should be more explicit, with a reference to the "publicising" of which you consider them guilty, and with your reasons for asking epidemiologists to make therapeutic recommendations.I presume that you must be referring to the account given by Speizer and Doll of the epidemic of asthma deaths in the 1960s, which were attributed to the overuse of strong isoprenaline aerosols.They carried out no publicity but only described their findings and suggested a possible cause.The Department of Health subsequently sent out the warning note to doctors that was followed by an immediate drop in asthma deaths.Has any clinician saved as many lives of asthmatics in his whole career as were saved by this simple public health measure?Have you any other explanation of the rise and fall of asthmatic deaths in the 1960?If not, I consider it most improper to attribute doctors' resistance to prescribing newer, safer aerosols to a factual account of an epidemic and an explanation
Tables Transposed
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mother and Unborn Child. A Little Book of Information and Advice for the Prospective Mother.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Occupational Asthma
Authors: Mark J. Ellenbogen
Journal: JAMA (1981)

This book is a compilation of current medical knowledge regarding asthma and various occupational etiologies. There is no initial overview of the problem of occupational asthma in regard to pathogenesis, diagnosis, and pulmonary function testing. Since there are innumerable possible exposures and environments, the editor has selected specific entities. Each chapter, however, does relate specific exposure to disease and provides data from detailed clinical and research investigation, which are well referenced and illustrated. This volume, taken as a whole, provides the physician with insight into the various problems of diagnosis and treatment of occupationally related obstructive airways disease. The chapter on exercise-induced asthma was quite well written and succinctly summarized various potential pathogenetic mechanisms. Immunologic mechanisms relating exposure to various agents and resultant bronchospasm are well documented in the chapters on byssinosis, farmer's lung disease, and Hoya (sea-squirt) asthma. This volume does not outline a systematic approach for the clinician
Social factors in suicide
Authors: G. E. Murphy
Journal: JAMA (1967)

Two diagnostic groups, affective disorder (depression) and alcoholism account for the majority of urban suicides. Alcoholic suicides are more often divorced, separated, or living alone than is the general population. Suicides with affective disorder differ little from the US population except in the proportion living alone. Unlike the affectivedisorder group, alcoholics are found frequently (32%) to have experienced obvious disruption of affectional relationships within six weeks of suicide. The findings suggest that suicide is often a response to social disturbance in alcoholism, chiefly to depressive symptoms in affective disorder. The alcoholic appears particularly vulnerable to suicidal impulses on losing an important affectional relationship. This knowledge should improve suicide prevention.
Effect of Human Serum and Tween 80 on Several Mycobacteriophages and Susceptible Mycobacteria 1,2
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clarification
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Modern Medicine
Authors: Edwin J. Grace
Journal: JAMA (1961)

<h3>To the Editor:—</h3> The article in the Dec. 3, 1960, issue ofThe Journal, entitled "Oral History: Living Moments of Modern Medicine," page 1884, has unfortunately ignored the deeper microbial events of the mid-twentieth century that have followed antibiotic therapy. The modern physician and medical biologist must now have a basic academic knowledge of the macro- and micro-evolution of life, from the microbe to man, over billions of years if "modern medicine" is to benefit from antibiotics. The slow, natural micro-evolutionary changes that have been going on since life began were altered by man when single antibiotics were used extensively for the treatment of infectious diseases. Therefore, the benefits derived from topical application of appropriate combinations of antibiotics for the treatment of infectious diseases and the prevention of resistant or mutating bacterial strains cannot be ignored. Since death, by cancer or man-made bacterial resistant organisms, is caused by cellular mutation,
Microvessel injury induced by ultrasound exposure with first generation contrast agent: Dominantly damaged venular and capillary endothelium Nobuhiko Kobayashi, Takanori Yasu, Masatoshi Kuroki, Masanobu Kawakami, Muneyasu Saito. Jichi Medical School Omiya Medical Center, Omiya, Japan
Journal: Journal of the American College of Cardiology (2001)
Revised guidelines on advanced life support cover the use of automated defibrillators
Journal: BMJ (1998)

Quality of care before admission to intensive care is often poor Emergency admissions have risen by 50% since 1984, but this rise in quantity should not be at the expense of quality.McQuillan et al (p 1853) used confidential inquiry methods to investigate the quality of care received by a consecutive cohort of 100 adult emergency patients in two hospitals.Oxygen therapy; management of airway, breathing, or circulation; or monitoring was suboptimal in over 50 patients.At least 39 patients were admitted late in their illness.These factors may be associated with increased morbidity and mortality and avoidable admissions to intensive care.The authors suggest a back to basics approach to managing dysfunction of airway, breathing, and circulation.The structure and process of acute care need reviewing to meet the challenge of the increasingly frenetic workload of the NHS.
Serum Creatine Phosphokinase (CPK) Activity in Disorders of Heart and Skeletal Muscle.
Authors: Joseph W. Hess
Journal: Annals of Internal Medicine (1964)

s1 February 1964Serum Creatine Phosphokinase (CPK) Activity in Disorders of Heart and Skeletal Muscle.Joseph W. Hess, M.D., R. P. MacDonald, Ph.D.Joseph W. Hess, M.D.Search for more papers by this author, R. P. MacDonald, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-318_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSerum enzyme determinations that are commonly available in hospital laboratories for aid in the diagnosis of diseases of the heart and skeletal muscle lack tissue specificity. Thus, it may be difficult to interpret elevated serum glutamic oxaloacetic transaminase (SGOT) and lactate dehydrogenase (LDH) activities in a patient suspected of having had an acute myocardial infarction, but who also has hepatic congestion, active liver disease, or has had a recent episode of shock. Likewise, patients with disorders that involve multiple tissue types including skeletal muscle may have elevated serum enzyme levels, but the relative contribution of the various organs cannot be... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySerum Creatine Phosphokinase (CPK) Activity in Disorders of Heart and Skeletal MuscleJOSEPH W. HESS, M.D., RODERICK P. MACDONALD, PH.D, RICHARD J. FREDERICK, M.S., ROBERT N. JONES, M.D., JOANN NEELY, M.D., DAVID GROSS, M.D. 1 February 1964Volume 60, Issue 2_Part_1Page: 318-318KeywordsEnzymesHeart diseasesLactate dehydrogenaseLiver diseasesMuscle tissueMyocardiumSerum glutamic oxaloacetic transaminaseShockSkeletal musclesSpecificity Issue Published: 1 February 1964 PDF DownloadLoading ...