tbuckley/cabot-search huggingface dataset:
Import-Associated Measles Outbreak--Indiana, May-June 2005
Journal: JAMA (2005)

On May 29, 2005, the Indiana State Department of Health (ISDH) was notified of suspected measles in a female Indiana resident aged 6 years who was hospitalized in Cincinnati, Ohio, where she had been visiting relatives. Serologic analyses performed by the Ohio State Department of Health Laboratory and a private reference laboratory confirmed the diagnosis of measles. The hospital in Cincinnati and the girl's parents told ISDH she had been at a church gathering in northwestern Indiana on May 15 where a fellow attendee had been ill. This fellow attendee was an adolescent girl aged 17 years, an Indiana resident who had not been vaccinated for measles and who had worked during May 4--14 as a missionary in an orphanage and hospital in Bucharest, Romania, where a large measles outbreak was subsequently reported. The teen had returned to the United States with prodromal fever, cough, conjunctivitis, and coryza, traveling on international and domestic commercial airliners on May 14. The next day the teen attended the church gathering along with others who had not been vaccinated because of nonmedical exemptions. Family members recalled that the teen had a rash on May 16; measles was diagnosed retrospectively, and the teen was identified as the index patient. An outbreak investigation was conducted by ISDH and CDC. This report summarizes 1) the results of that investigation, which identified 34 persons with measles, including three who required hospitalization, 2) the measures taken to control and prevent measles transmission, and 3) recommendations to prevent future cases of measles.
Recurrent meningococcal infection with an antigenically identical strain
Authors: J. M. Griffiss
Journal: JAMA (1974)

Meningococcal infection usually confers immunity in the form of bactericidal antibodies to both the infecting and unrelated strains of meningococci. Recurrent attacks are rare and documentation of the serogroup involved in both episodes of such attacks is rarer still. A case of recurrent group B meningococcal disease occurred in a child who developed bactericidal antibodies to both infecting strains. Both serogroup and serotype antigens of the two infecting strains were identical. (<i>JAMA</i>229:68-70, 1974)
Annual Congress on Medical Education
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnosing Gout between Painful Episodes
Journal: Annals of Internal Medicine (1999)

Summaries for Patients16 November 1999Diagnosing Gout between Painful EpisodesSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-10-199911160-00045 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Gout is a type of arthritis that happens when uric acid crystals form in a joint. These crystals can form when blood levels of uric acid are high. The underlying cause of gout is unknown, but it tends to run in families. Any joint may be involved, but the joint where the big toe meets the foot is the most common site. During gout attacks, which tend to occur periodically, the joints become swollen, red, and painful. To diagnose gout, a physician puts a needle into the affected ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Synovial Fluid Analysis for Diagnosis of Intercritical Gout.” It is in the 16 November 1999 issue of Annals of Internal Medicine (volume 131, pages 756-759). The authors are E. Pascual, E. Batlle-Gualda, A. Martínez, J. Rosas, and P. Vela.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. Previousarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSynovial Fluid Analysis for Diagnosis of Intercritical Gout Eliseo Pascual , Enrique Batlle-Gualda , Agustín Martínez , José Rosas , and Paloma Vela Metrics 16 November 1999Volume 131, Issue 10Page: 756KeywordsArthritisBloodGoutKnee jointsKneesSynovial fluidUric acid Issue Published: 16 November 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.Loading ...
A legacy of Osler. Teaching clinical ethics at the bedside
Authors: M. Siegler
Journal: JAMA (1978)

The teaching of clinical medicine at the bedside is an enduring legacy of the Oslerian revolution in American education. The advantages of teaching clinical ethics at the bedside include dealing with actual cases to maximize personal accountability, reinforcing the relationship between technical competence and ethical decisions, involving the entire health care team, and possibly decreasing the resistance of the medical profession to formal medical ethics. The proposal to teach clinical ethics at the bedside is intended to indicate a primary role for ethicists and clinicians at different stages in the medical curriculum. During the preclinical years of medical school, ethicist-philosophers, assisted by clinicians, should assume primary responsibility for teaching medical ethics. During the clinical years, physicians, assisted by clinically informed ethicist-philosophers, should accept the primary obligation to teach clinical ethics at the bedside. (<i>JAMA</i>239:951-956, 1978)
Genomic characterization of primary and metastatic prostate cancer (PC) using a targeted next-generation sequencing assay.
Authors: Wassim Abida, Kristen Rebecca Curtis, Barry S. Taylor, Maria E. Arcila, Ryan Brennan, Daniel Costin Danila, Dana E. Rathkopf, Michael J. Morris, Susan F. Slovin, David B. Solit, David Michael Hyman, Anuradha Gopalan, Michael F. Berger, Nikolaus Schultz, Howard I. Scher
Journal: Journal of Clinical Oncology (2015)

5062 Background: Genomic alterations in PC have been described across the disease continuum, creating opportunities for selective clinical trial enrollment of patients (pts) with high-risk or metastatic disease based on their tumor profile. MSK-IMPACT is an exon capture-based sequencing assay performed in a CLIA-certified laboratory that targets 341 cancer-associated genes, many of which are potential drug targets. We assessed mutations and copy number alterations (CNAs) in primary and metastatic samples from untreated, hormone-treated and castration resistant pts. Methods: Pts with localized and metastatic PC were enrolled on an IRB-approved protocol for tumor genomic profiling. Fixed tumor and matched germline samples were subjected to DNA sequencing analysis using MSK-IMPACT for the identification of somatic mutations and CNAs. Results: 135 tumor samples from 124 pts were successfully sequenced, including 83 primary and 52 metastatic tumors. Metastatic sites include LN (22), bone (12), liver (6), lung (2) and other soft tissue (10). 5 tumors were pathologically classified as neuroendocrine. Common alterations in the metastatic tumors include TP53 deletion/mutation (44%), AR amplification/mutation (38%), PTEN deletion/mutation (29%), RB1 deletion/mutation (17%), BRCA2 deletion/mutation (13%), FOXA1 mutation (12%) and SPOP mutation (8%). Common alterations in the primary tumors (67% with Gleason > 7) include TP53 mutation (20%), SPOP mutation (11%) and PTEN deletion/mutation (10%). Among metastatic samples, tumors from pts with castration resistant disease have higher CNA burden when compared to tumors from untreated or castration-sensitive pts (0.30 vs. 0.19 fraction genome altered, p < 0.05, unpaired t-test) as well as higher rates of AR amplification/mutation (50% vs. 7%, p < 0.01, Fisher’s exact test). Conclusions: Genomic profiling of primary and metastatic prostate tumors is feasible with the targeted MSK-IMPACT assay and recapitulates findings from broader whole exome-based studies. This will facilitate genomic biomarker development and the rational selection of single-agent or combination therapy trials for pts with high-risk and metastatic disease.
Non-invasive liver fibrosis markers, FIB-4, PRO-C3 and ADAPT, are significantly elevated in biopsy confirmed NAFLD patients at high risk of developing coronary heart disease and cardiovascular disease and are promising clinical decision making tools
Authors: Samuel Daniels, Mette Nielsen, Mohammed Eslam, Morten Karsdal, Leon Adams, Jacob George
Journal: Journal of Hepatology (2020)
In This Issue
Journal: Journal of Clinical Investigation (2010)

TRPM4 keeps blood pressure downHypertension is a risk factor for many serious health conditions, including stroke, end-stage renal disease, and heart disease.However, in most patients, the underlying cause is unknown.Increased understanding of the regulation of blood pressure might provide new insight into the pathogenesis of hypertension.In this context, Mathar and colleagues have identified a role for transient receptor potential cation channel, subfamily M, member 4 (TRPM4) in regulating blood pressure in mice (3267-3279).Initial analysis indicated that TRPM4 was expressed in cells and tissues of the mouse cardiovascular system, suggesting a role for TRPM4 in this system.Consistent with this, Trpm4 -/- mice were hypertensive and developed cardiac hypertrophy at 6-8 months of age.Further analysis revealed the mechanism underlying the increased blood pressure in Trpm4 -/-mice.Specifically, lack of TRPM4 in chromaffin cells in the adrenal gland caused increased release of catecholamines, leading to increased sympathetic tone and hypertension.The authors therefore conclude that TRPM4 limits catecholamine release from chromaffin cells and that disruption of this control, as occurs in mice lacking TRPM4, increases blood pressure.They further suggest that boosting TRPM4 activity might help limit blood pressure increases in patients with hypertension.
Prescription drugs and driving performance
Authors: V. Cowart
Journal: JAMA (1985)

Increased public awareness of the role that alcohol plays in traffic injuries and deaths has led several states to enact harsher penalties for driving under its influence or for serving alcohol to an already intoxicated person who then may try to drive. Less well known or understood, however, are the possible effects on driving performance of prescription and nonprescription medications. Two pioneer meetings on this latter subject were held recently, one in Europe and the other in the United States. At the same time, the medications-and-driving question is the subject of another first step, one being taken by the National Highway Traffic Safety Administration, Washington, DC, which expects to have a provision in its forthcoming budget for an epidemiologic study. This study will gather data on drugs other than alcohol found in blood and urine specimens (<i>JAMA</i>[Medical News] 1985;253:3509-3517) from drivers fatally injured in traffic crashes and in a
Cerebrospinal Fever
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JOHN REDMAN (1722-1808)— CHAMPION OF INOCULATION
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: Circulation (2010)

several corrections were needed.1. On page 2481, in the left column, the last sentence read, "From 2006 to 2010, the average calories per 8 oz of flavored milk in schools decreased from 165.8 to 152.9."It has been updated to read, "From 2006 to 2010, the average calories per 8 oz of flavored milk in schools decreased from 165.8 to 154.0."2.
TUBERCULOSIS OF THE DOG.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SIR HENRY HALLETT DALE
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
STEROID-INDUCED GASTRIC ULCER
Journal: JAMA (1966)

ansemia, was caused by the barbiturates she was taking.Both amylobarbitone sodium and quinalbarbitone sodium, the constituents of tuinal, are closely related chemically to primidone, sodium phenytoin, and phenobarbitone, but a megaloblastic anaemia has not previously been described in association --ith their use.The doses that this patient was taking (gr. 18-20for 6-8 months) were, however, in excess of the usual doses given.In view of the accumulating evidence that barbiturates interfere with the metabolism of folic acid, it appears desirable that the signs of early folic-acid deficiency should be sought in all patients who receive large doses of barbiturates for any length of time. SummaryA woman, aged 30, who had acquired the habit of taking large doses of amylobarbitone sodium and quinalbarbitone sodium became critically ill with severe megaloblastic anaemia.Her serum-vitamin-B12 level before treatment was normal, and she did not respond to treatment with vitamin B12.Her ansemia, however, responded rapidly to treatment with folic acid.Her diet was adequate and no significant impairment of intestinal absorption was found.We wish to thank Dr. I. Chanarin, of the 'department of pathology* (haematology) for the folic-acid assay; Dr. E.
Pediatric Radiology
Authors: Edward B. D. Neuhauser, Martin H. Wittenborg
Journal: New England Journal of Medicine (1953)

DURING the past few years there have been tremendous advances in pediatric radiology. The number of articles devoted to this subject has increased so greatly that the task of the reviewer becomes difficult in selecting the articles of most value. In a review of moderate length one can hope to cover only a few of the important contributions recently made in the field of pediatric radiology.Many of the diseases and abnormalities observed in children present radiologic findings similar to or identical with those seen in adults. Studies of these diseases among children reveal only the relative incidence and, at . . .
Development of an Assay for a Biomarker of Pregnancy and Early Fetal Loss
Authors: R. E. Canfield, J. F. O'Connor, S. Birken, A. Krichevsky, A. J. Wilcox
Journal: Environmental Health Perspectives (1987)

Human chorionic gonadotropin (hCG) is a glycoprotein hormone, secreted by the syncytiotrophoblast cells of the fertilized ovum, that enters the maternal circulation at the time of endometrial implantation. It is composed of two nonidentical subunits; alpha and beta, with molecular weights of 14 kD and 23 kD, respectively. Its alpha subunit is identical in primary structure to its glycoprotein homologs, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH). Human chorionic gonadotropin binds to the same receptor as hLH and displays the same biological response, namely, to stimulate the declining function of the corpus luteum to produce progestins and estrogen late in the menstrual cycle. The differences in the structures of hCG and hLH have been exploited to develop antibodies that can measure hCG specifically in the presence of hLH. Two-site antibody binding assays have been developed, based on a surface immunological concept of hCG epitopes, that involve four distinct regions to which antibodies against hCG can bind simultaneously. Antibody cooperative effects, in conjunction with kinetic advantages derived from the concentration factors by use of the sandwich assay technique (immunoradiometric assay, IRMA), have enabled development of extremely sensitive and specific measurement protocols for urinary hCG. The assay described herein permits the detection of pregnancy on an average 25.4 days after the first day of the preceding menses, as opposed to 29.5 days for conventional radioimmunoassay techniques. In addition, the greater sensitivity and specificity of this assay method has permitted the detection of episodes of fetal loss not detected by radioimmunoassay of urine specimens. A large scale epidemiological study is in progress using this assay technique as a way to identify pregnancies that are lost before becoming clinically apparent. This methodology provides a valuable tool for the determination of the rate of early fetal loss.
Book Review Lipiodol in the Diagnosis of Thoracic Disease . By F. G. Chandler, M.A., M.D. (Cantab.), F.R.C.P. (Lond.), Physician with Charge of Out-Patients, Charing Cross Hospital; Physician, City of London Hospital for Diseases of Heart and Lungs, Victoria Park, E. W. Burton Wood, M.A., M.D. (Cantab.), M.R.C.P. (Lond.), Physician with Charge of Out-Patients, City of London Hospital for Diseases of the Heart and Lungs, Victoria Park, E. Oxford University Press, 1928, pp. 129. Price $3.50.
Journal: New England Journal of Medicine (1929)
Disequilibrium hypercalcaemia.
Authors: D J Hosking
Journal: BMJ (1983)

official statements (or of The Rising Tide) were shown to the college for comment, despite a happy tradition of consultation on such matters; no doubt agreement could be reached, for on essential purposes there is no dispute.Why not let the new awards go simply to good schemes for improving the services ?-they could be called, say, "development awards," and could go to places that have nothing, to leading centres to enable them to do still better, and to all points in between.Tested repute rather than formal designation may safely continue to identify what is worth demonstrating.