tbuckley/cabot-search huggingface dataset:
Treatment of Verrucae With Smallpox Vaccine
Authors: Kenneth W. Thompson
Journal: JAMA (1969)

<h3>To the Editor:—</h3> The article, "Treatment of Verrucae With Smallpox Vaccine" (<b>206</b>:117, 1968), prompts me to report on my experiences with plantar warts. In each case, the warts dried up and the base healed without surgery or other therapy after response to a strong immunological stimulus. Regrettably, the observations had to be discontinued before an entirely convincing study had been completed. Nevertheless, in view of the context of the above publication, the following notes may be of interest. A woman who had dozens of warts on both feet had repeated electrocauterizations; all failed until a severe Staphylococcus aureus hemolytic infection developed. A similar accidental infection occurred in a boy after electrocoagulation of a dozen large warts on one foot prior to treatment of those on the other foot. After control of the infection the warts on both feet healed within a month with no further treatment.
Post-Mortem Appearances.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hemodialysis-Associated Hepatitis
Authors: Richard A. Garibaldi
Journal: JAMA (1973)

Of 65 renal hemodialysis units surveyed prospectively by the Center for Disease Control in the four-year period 1967 to 1970, fifty-three reported 355 cases of viral hepatitis—260 in hemodialysis patients and 95 in hemodialysis unit staff members. The incidence of infection in 1970 for center-based patients and staff was 4.4 cases and 3.4 cases, respectively, per 100 persons at risk. Almost 70% of the hemodialysis patients were anicteric; many of these cases would not have been detected if periodic serologic screening for hepatitis B antigen or liver-function tests had not been performed routinely. On the other hand, 85% of staff members with hepatitis were jaundiced, and 74% required hospitalization. Although accidental needle punctures prior to hepatitis were reported by many staff, other types of exposures were common, and nonparenteral transmission probably occurred.
Oral Methadone Maintenance
Authors: Jordan M. Scher
Journal: JAMA (1972)

<h3>To the Editor.—</h3> I would like to respond to the letter "Oral Methadone Maintenance" by Dr. G. James Berry, which appeared in a recent issue ofThe Journal(220:1617, 1972). Over the past 2 1/2 years we have been involved in observing patients maintained with methadone hydrochloride in a clinic for this purpose. Although it is certainly true that a certain percentage of patients can and will be maintained with dosages as low as 30 mg/day (we have one who is taking 10 mg/day), we do not feel that the implication that most can be maintained with anything like this low dosage should gain credence. Many factors influence dosage, such as psychological situations, habits of previous abuse, fears concerning proper maintenance dosage, variations in perspiration rates, kinds of work, and intercurrent emotional states. In our observation, most of these patients require between 60 and 90 mg of methadone hydrochloride, with
Driving and Epilepsy
Authors: Allan Krumholz
Journal: JAMA (1991)

Driving and epilepsy is a problem that involves physicians as both care providers to patients and consultants to regulatory authorities. Driving restrictions for people with seizure disorders are intended to ensure the public's safety, but such restrictions may unduly harm the welfare of many people with seizures. In the United States, all states now permit some people with epilepsy to drive. In general, only people whose seizures are adequately controlled are licensed to drive. Adequate control has been judged principally by the seizure-free interval, but individual state standards widely vary. There is a trend toward greater liberalization of driving standards for people with seizure disorders, but the appropriateness and application of these standards continue to raise questions, as does the role physicians should have in the licensing process. Our responsibilities to persons with disabilities and advances in our understanding of seizures and the nature of driving risks warrant a reappraisal of the current medical, legal, and social implications of driving and epilepsy. (<i>JAMA</i>. 1991;265:622-626)
Carbohydrate Metabolism:
Authors: A Iguchi, H Miura, N Sakamoto
Journal: Annals of Internal Medicine (1953)

This review summarizes progress in glycosylation research of relevance to atherosclerosis. Glucose reacts in vivo with cellular proteins nonenzymatically and forms Amadori products. The Amadori products proceed very slowly to undergo a number of further dehydration and rearrangement to form advanced glycosylation end products (AGE). The AGE moiety are characterized by being brown, fluorescent chromophores that can cross-rink proteins. In contrast Amadori products, AGE are irreversible and accumulate on long-lived proteins (eg, collagen, enzyme, lens crystallins) for many years. AGE proteins can modify lipoproteins fibrinogen, collagen and DNA. AGE protein receptor is identified on macrophages. AGE may accelerate development of atherosclerosis by various manner.
Grading referrals to specialist breast units
Authors: V. L Allgar
Journal: BMJ (2002)

<h3>Abstract</h3> The design of compounds that can discriminate between closely related target proteins remains a central challenge in drug discovery. Specific therapeutics targeting the highly conserved myosin motor family are urgently needed as mutations in at least 6 of its members cause numerous diseases. Allosteric modulators, like the myosin-II inhibitor blebbistatin, are a promising means to achieve specificity. However, it remains unclear why blebbistatin inhibits myosin-II motors with different potencies given that it binds at a highly conserved pocket that is always closed in blebbistatin-free experimental structures. We hypothesized that the probability of pocket opening is an important determinant of the potency of compounds like blebbistatin. To test this hypothesis, we used Markov state models (MSMs) built from over 2 milliseconds of aggregate molecular dynamics simulations with explicit solvent. We find that blebbistatin’s binding pocket readily opens in simulations of blebbistatin-sensitive myosin isoforms. Comparing these conformational ensembles reveals that the probability of pocket opening correctly identifies which isoforms are most sensitive to blebbistatin inhibition and that docking against MSMs quantitatively predicts blebbistatin binding affinities (R<sup>2</sup>=0.82). To test our ability to make blind predictions, we predicted blebbistatin’s binding affinity for an isoform (Myh7b) whose blebbistatin sensitivity was unknown. Encouragingly, we find good agreement between the predicted and measured IC50 (0.67 µM vs. 0.36 µM). Therefore, we expect this framework to be useful for the development of novel specific drugs across numerous protein targets. <h3>Significance</h3> Drug development requires the discovery of compounds which specifically target one member of a protein family without triggering side effects that arise from interactions with other related proteins. Myosins are a family of motor proteins that are drug targets for heart diseases, cancer, and parasitic infections. Here, we investigate why the compound blebbistatin specifically inhibits some myosins more potently than others, even though its binding site is closed in all known experimental structures. We find that the blebbistatin binding pocket opens in molecular dynamics simulations of certain myosin motors, and that the probability of opening predicts how potently blebbistatin inhibits a particular motor. Our work suggests that differences in cryptic pocket formation can be exploited to develop specific therapeutics.
Bear Meat Hazards
Authors: J. P. Nater
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Dr. Paul J. Mattes,<sup>1</sup>in a reaction to the EDITORIAL "Dangers of Eating Bear Meat"<sup>2</sup>recently made the supposition that Andrée and his fellow balloonists may have perished as a result of trichinosis combined with a hypervitaminosis A intoxication caused by the consumption of bear liver. In my opinion, a correction on this point is necessary. The danger of eating bear liver (but not bear meat!) was well known to explorers, ever since Gerrit de Veer, the chronicler of Willem Barentz (1597) gave the first description of the symptoms of bear liver intoxication.<sup>3</sup>The diary of Andrée found on his body in 1930 makes it absolutely clear that this danger was known to him. As a matter of fact, Andrée was an experienced balloonist and polar explorer. The technical knowledge of our days makes his expedition perhaps absurd in our eyes. The cause of
Osteitis Condensans Ilii
Authors: John C. Soucy
Journal: JAMA (1969)

Osteitis condensans ilii is an entity which should be considered in the differential diagnosis of pain in the low part of the back. Diagnosis can be confirmed by roentgenologic examination. To our knowledge, this is the first case reported in an American Indian. The cause and pathogenesis of this entity is unclear and it is suggested that anti-inflammatory agents may be of benefit in certain cases.
Pathology: General and Special for Students of Medicine.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunodeficiency Diseases
Authors: G Virella
Journal: JAMA (1992)

ALTHOUGH more than 50 genetically determined immunodeficiency syndromes have been reported since 1952,<sup>1</sup>defects in immunity were considered rare until the acquired immunodeficiency syndrome (AIDS) emerged over 10 years ago.<sup>2</sup>This growing list of diseases now encompasses all major components of the immune system, including lymphocytes, phagocytic cells, and complement proteins.<sup>1,3-5</sup> <h3>EVALUATION OF THE PATIENT WITH RECURRENT INFECTIONS</h3> It is essential that the clinical and laboratory tests selected for immunologic assessment be broadly informative, reliable, and cost-effective. Most of these disorders can be ruled out at little cost to the patient if the proper choice of screening tests is made (Table 2-1). A complete blood cell count and erythrocyte sedimentation rate are among the most cost-effective screening tests. If the erythrocyte sedimentation rate is normal, chronic bacterial infection is unlikely. If the absolute neutrophil count is normal, congenital and acquired neutropenias and severe chemotactic defects are eliminated.
Endogenous adenosine increases O2 utilisation efficiency in isoprenaline-stimulated canine myocardium
Authors: R. T. Mallet, S.-C. Lee, H.F. Downey
Journal: Cardiovascular Research (1996)

Objective: We have previously demonstrated that myocardium is capable of down-regulating its O2 requirements and thus avoiding ischaemia when O2 supply is limited. The present study tested the hypothesis that endogenous adenosine produced this protective response when O2 supply was decreased by moderate coronary hypopertusion or moderate coronary hypoxaemia. Methods: In anaesthetised dogs, hearts were exposed by left thoracotomy and instrumented for measuring intraventricular pressure and regional myocardial segment length. The left anterior descending coronary artery was isolated, cannulated, and extracorporeally perfused. Coronary O2 supply was moderately reduced by lowering coronary perfusion pressure from 100 to 60 mmHg or by lowering coronary arterial O2 content by 50%. Hearts were treated with intracoronary infusions of adenosine, adenosine deaminase to degrade endogenous adenosine or with erythro-9-(2-hydroxy-3-nonyl)-adenine · HC1 (EHNA) to inhibit adenosine degradation by endogenous adenosine deaminase, during β-adrenergic stimulation with isoprenaline. Cardiac power in the left anterior descending perfusion territory was indexed by the product of heart rate · left ventricular peak systolic pressure · percent systolic segment shortening. O2 utilisation efficiency was taken as the ratio of power index/myocardial O2 consumption. Results: Prior to a reduction in O2 supply, isoprenaline did not alter O2 utilisation efficiency. Intracoronary adenosine increased O2 utilisation efficiency during isoprenaline stimulation by 23% (P <0.05). EHNA slightly increased O2 utilisation efficiency during isoprenaline stimulation (10%; P < 0.05); adenosine deaminase was without effect. When coronary perfusion pressure was decreased, adenosine deaminase sharply lowered cardiac power and O2 utilisation efficiency during isoprenaline stimulation, whereas EHNA augmented isoprenaline-enhanced power and increased efficiency. During hypoxaemia, adenosine deaminase lowered regional power but not efficiency during isoprenaline infusion; EHNA did not affect power but lowered O2 consumption and increased efficiency. Myocardial lactate extraction and contractile function during isoprenaline stimulation were not attenuated by reduced O2 supply, indicating that myocardial ischaemia did not occur under these conditions. Conclusion: Endogenous adenosine increases myocardial O2 utilisation efficiency during β-adrenergic stimulation, and thus helps avert ischaemia when myocardial O2 supply is reduced.
Pheochromocytoma Diagnosed by Liver Scan
Authors: James B. Gillick
Journal: JAMA (1966)

<h3>To the Editor:—</h3> The liver scan is attaining an increasing clinical usefulness as investigators gain more experience with the indications and interpretation of this test. In most instances, results of other liver function tests are abnormal when the liver scan demonstrates discrete or diffuse hepatic lesions.<sup>1</sup>In this case, the liver scan demonstrated a nonhepatic tumor and was the only criterion which led to a decision to perform laparotomy. The lesion, in fact, was a large asymptomatic pheochromocytoma, which revealed its presence by way of its unusual alteration of liver anatomy. <h3>Report of a Case:—</h3> A 68-year-old retired records clerk came to the Portland Veterans Administration Hospital because of a 25-lb weight loss in the preceding six months. His illness began three months before admission when a dull left-upper-quadrant abdominal pain which was constant and radiated to his left flank suddenly developed. Ten days later he noticed blood in
The Examination of Waters and Water-Supplies.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dietary Fat and Risk of Breast Cancer
Authors: Knut M. Wittkowski, Steven J. Shiff, Jules Hirsch
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The lack of relationship between hepatotoxicity and lithocholic-acid sulfation in biliary bile acids during chenodiol therapy in the national cooperative gallstone study
Authors: Rosemarie L. Fisher, Alan F. Hofmann, James L. Converse, Steven S. Rossi, Shu-Ping Lan
Journal: Hepatology (1991)

To test whether hepatotoxicity occurring in National Cooperative Gallstone Study patients was caused by a toxic effect of chenodiol per se or of lithocholate caused by defective sulfation, bile samples were analyzed using a new high-performance liquid chromatography method that measures the proportions of the four individual lithocholate amidates (sulfated and unsulfated lithocholylglycine and lithocholyltaurine) and all common bile acid amidates. Samples were obtained from National Cooperative Gallstone Study patients (n = 17) with abnormal light microscopic liver biopsy results or major aminotransferase elevations and from a matched control group of patients (n = 14) who received similar chenodiol doses but had no evidence of liver injury. Bile samples from 45 healthy subjects were also analyzed. The analytical method was validated by showing that the percentage of chenodiol and cholic and deoxycholic acid obtained by highperformance liquid chromatography correlated highly (r &gt; 0.94) with previous gas-liquid chromatography analyses of these samples by the National Cooperative Gallstone Study Reference Laboratory. No significant differences were seen between gallstone patients with and without evidence of liver injury for percent total lithocholate amidates, percent sulfated or unsulfated lithocholate amidates or percent chenodiol amidates. Lithocholate was partially sulfated in all bile samples (52% ± 17% [mean ± S.D., n = 50]), but the extent of sulfation varied widely between and within patients during the course of therapy. Mean values of healthy subjects were similar and also showed a wide range in the extent of lithocholate sulfation. It is concluded that (a) liver injury caused by these doses of chenodiol could not be attributed to the accumulation of unsulfated lithocholate per se in circulating bile acids; (b) liver injury appeared to be, directly or indirectly, caused by enrichment in circulating bile acids with chenodiol or chenodiol together with lithocholate, suggesting that the hepatocytes of those patients with hepatotoxicity were injured by the change induced in bile-acid metabolism by the feeding of chenodiol; and (c) about half of lithocholate amidates in bile samples were sulfated, but the extent of sulfation was highly variable both in gallstone patients and healthy subjects.