tbuckley/cabot-search huggingface dataset:
"A CLERICAL ERROR."
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ITALY
Journal: JAMA (1927)

<h3>Congress of Obstetrics and Gynecology</h3> Under the chairmanship of Professor Mangiagalli, rector of the University of Milan, the Società italiana di ostetricia e ginecologia held its twenty-fifth congress in Modena. The meeting was opened with an address by the president of the society, Prof. Guzzoni Degli Ancarani, who gave a brief account of the instruction in obstetrics in Modena. Papers were presented on four main topics: <h3>FIBROMAS AND CANCER OF THE UTERUS</h3> Professor Mangiagalli presented the opening paper on "A Half Century's Experience in the Treatment of Fibromas and Cancer of the Uterus." The first abdominal hysterectomy for fibroma was performed by Mangiagalli in 1878. From that date on, he had performed the operation 1,598 times with variable mortality, but for the last hundred cases it had not exceeded 5 per cent. He stated that roentgen rays had assumed a notable position as the handmaid of conservative surgery. Mangiagalli has
Working with African nations to improve the health of their children. Combatting childhood communicable diseases
Authors: S. O. Foster
Journal: JAMA (1990)

OF THE 20 million children born each year in Africa, 4 million will die before their fifth birthdays.<sup>1</sup>Over half of these deaths are directly attributable to one or more diseases in the following groups: diseases preventable by immunization (including measles, neonatal tetanus, and pertussis), diarrhea, malaria, and acute lower respiratory tract infection.<sup>2</sup>In a longitudinal study of mortality in Kivu, Zaire, 424 (68%) of 624 deaths in children under 5 years of age were related to these four groups of diseases.<sup>3</sup> As part of the US Agency for International Development's technical assistance to Africa, the Combatting Childhood Communicable Diseases (CCCD) project works with 10 African countries to strengthen their national capacity to reduce childhood morbidity and mortality and improve child health. These countries are the Central African Republic, Burundi, Cote d'Ivoire, Guinea, Lesotho, Liberia, Nigeria, Swaziland, Togo, and Zaire. This article reports on program experience during
This Week in &lt;emph&gt;JAMA&lt;/emph&gt;
Journal: JAMA (2009)

A Piece of My Mind"It is hard to believe that in this modern age, when there are seemingly inexhaustible ways of achieving a given outcome, we all draw a blank at Mr V." From "Dying to Talk." SEE PAGE 807 Medical News & PerspectivesAlthough the US Food and Drug Administration stood by its approval of ezetimibe/simvastatin after reviewing data showing it reduces levels of lowdensity lipoprotein cholesterol, whether the drug actually improves clinical outcomes remains unknown.
PSYCHIATRIC INTERNSHIP
Authors: GROSVENOR B. PEARSON, KATHRYN L. SCHULTZ
Journal: American Journal of Psychiatry (1945)

It is recommended that interns be given more formal instruction in psychiatry during the fifth year of medical education. While there are many objections, the advantages to the individual seem to outweigh the disadvantages. It is believed that internships could be arranged so as to include this type of service, and that a sufficient number of mental hospitals with competent personnel for teaching could be found. General hospitals will have to concede some points, and organized protests in favor of increased psychiatric teaching would be helpful. The experience at Pittsburgh is described as an example of what can be done to include a psychiatric service in a rotating internship. As might be expected, the intern fresh from a busy medical or surgical service finds it hard to adjust to the different tempo of a mental hospital, with its confusing exactness. Fortunately, most interns lose all or the larger part of their fear of psychiatry as they become acquainted with it. It seems inevitable that this will be an advantage to them in later years. Formerly the average intern went into private medical practice at once or soon after his internship; today he enters the Army or Navy where the demand on him for psychiatric insight exceeds ordinary expectations. Because of this, a special effort should be made to familiarize him with the early forms of mental illness, preventive measures, social aspects, and the relationship of psychiatry to other forms of medicine.
Issue Highlights
Journal: Circulation (2007)

In collaboration with science journals throughout the world and as part of a Global Themed Issue on Poverty and Human Development, this week's Circulation includes 2 original articles pertinent to this topic.First, the article by Larrazabal et al discusses the progress made in congenital heart disease surgery in Guatemala.This study describes an effort that was made in 1997 to disseminate US pediatric cardiac surgical practices in Guatemala with the objective of examining the reduction in mortality in the new Guatemalan cardiovascular program as compared with similar programs in the United States.When comparing the Guatemalan mortality rate against the United States benchmark (KID 2000 database), a decrease in standardized mortality ratio from 10 in 1997 to 1999 to 5.7 in 2003 to 2004 was observed (Pϭ0.008).The authors address some potential confounders, and despite these potential limitations, the study suggests that, with a dedicated effort, third-world countries can improve the quality of care provided within their borders.See p
'Please pass the roach poison' again
Authors: M. Kleerekoper
Journal: JAMA (1992)

"Reduce hip fractures among people aged 65 and older sothat hospitalizations for this condition are no more than 607 per 100000. (Baseline: 714 per 100000 in 1988)"<sup>1</sup> This terse directive to the health care and lay communities alike acknowledges hip fractures as a major community health problem. It also emphasizes the significant potential for reduction in the incidence of these fractures, provided adequate attention is given to controllable risk factors. The challenge to all of us is to identify these factors, with an emphasis on those that are most cost-effective. See also p 746. Several studies have demonstrated that 5 to 10 years of estrogen replacement for perimenopausal women will reduce the incidence of hip and other osteoporotic fractures by as much as 50%.<sup>2</sup>While it is currently my practice to prescribe estrogen to all perimenopausal women in whom there is no contraindication, there is still considerable debate
Biomarkers of Environmental Benzene Exposure
Authors: C. Weisel, R. Yu, A. Roy, P. Georgopoulos
Journal: Environmental Health Perspectives (1996)

Environmental exposures to benzene result in increases in body burden that are reflected in various biomarkers of exposure, including benzene in exhaled breath, benzene in blood and urinary trans-trans-muconic acid and S-phenylmercapturic acid.A review of the literature indicates that these biomarkers can be used to distinguish populations with different levels of exposure (such as smokers from nonsmokers and occupationally exposed from environmentally exposed populations) and to determine differences in metabolism.Biomarkers in humans have shown that the percentage of benzene metabolized by the ring-opening pathway is greater at environmental exposures than that at higher occupational exposures, a trend similar to that found in animal studies.This suggests that the dose-response curve is nonlinear; that potential different metabolic mechanisms exist at high and low doses; and that the validity of a linear extrapolation of adverse effects measured at high doses to a population exposed to lower, environmental levels of benzene is uncertain.Time-series measurements of the biomarker, exhaled breath, were used to evaluate a physiologically based pharmacokinetic (PBPK) model.Biases were identified between the PBPK model predictions and experimental data that were adequately described using an empirical compartmental model.It is suggested that a mapping of the PBPK model to a compartmental model can be done to optimize the parameters in the PBPK model to provide a future framework for developing a population physiologically based pharmacokinetic model.
Aspects of the Release of Superoxide by Leukocytes, and a Means by Which This Is Switched off
Authors: Manfred L. Karnovsky, Amy Bishop, Valeria C. P. C. Camerero, Mercedes A. Paz, Pio Colepicolo, Jose M. C. Ribeiro, Paul M. Gallop
Journal: Environmental Health Perspectives (1994)

Although great progress has been made in understanding the respiratory burst of leukocytes that produce superoxide (0-), it is possible that a com- ponent, or components, might have been overlooked.Furthermore, 0°production and its sequels, though cardinal in bactericidal action, might ulti- mately be damaging to the host's own cells.It is important, therefore, that a biologic mechanism exist to turn off 0°production by stimulated leukocytes.This article offers evidence that methoxatin (P00), a redox-cycling orthoquinone, might be involved in 0°production by leukocytes.This is based on the fact that inhibitors of 0°production, such as diphenylene iodonium (DPI) and 4,5-dimethylphenylene diamine (DIMPDA), were shown to sequester PQQ in leukocytes, i.e., to form adducts with that substance.Addition of PQQ to cells blocked with the inhibitors partially restored 0°release.With respect to turning off cellular °2 release, a factor was observed to be released to the medium by old macrophages (14 days old, but not by those less than 7 days old).Such conditioned medium, when added to stimulated neutrophils or macrophages, blocked 02 release.This factor was sensitive to proteases, exhibited molecular sizes of 3 and 11 kDa, and its action was independent of the nature of the stimulus applied to the leukocytes.It was partially purified by column (sizing) chromatography and HPLC.It seems to be a general modulator of the release of reactive oxygen species by phagocytes and is irrespective of phagocytic cellular type, or species from which the cells were derived.
Current Approaches for the Diagnosis and Treatment of Gastrointestinal Cancers: Thirtieth Annual Clinical Conference
Journal: JNCI Journal of the National Cancer Institute (1986)

Journal Article Current Approaches for the Diagnosis and Treatment of Gastrointestinal Cancers: Thirtieth Annual Clinical Conference Get access JNCI: Journal of the National Cancer Institute, Volume 77, Issue 1, July 1986, Page 310, https://doi.org/10.1093/jnci/77.1.310-a Published: 01 July 1986
Diagnosing Ehrlichiosis
Authors: Drury M. Stith
Journal: Annals of Internal Medicine (1996)

Letters1 May 1996Diagnosing EhrlichiosisDrury M. Stith, MDDrury M. Stith, MDEastern Shore Physicians & Surgeons; Nassawadox, VA 23413Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-9-199605010-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I was interested in the recent article by Telford and colleagues [1]. I have seen three documented cases of ehrlichiosis among patients from the eastern shore of Virginia. The first was that of a 61-year-old man admitted to our hospital in May 1994. He was acutely ill with conjunctivitis, hepatitis, pancreatitis, acute renal failure, leukopenia, and thrombocytopenia. He improved slowly after receiving doxycycline therapy. Ehrlichia antibody tests were done by National Health Laboratories at Herndon, Virginia. The acute titers to Ehrlichia IgM and IgG were 1:16 on 25 May 1994. On 9 June, the Ehrlichia IgM antibody ...REFERENCE1. Telford SR 3d, Lepore TJ, Snow P, Warner CK, Dawson JE. Human granulocytic ehrlichiosis in Massachusetts. Ann Intern Med. 1995; 123:277-9. Google Scholar Author, Article, and Disclosure InformationAuthors: Drury M. Stith, MDAffiliations: Eastern Shore Physicians & Surgeons; Nassawadox, VA 23413 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1996Volume 124, Issue 9Page: 854KeywordsAcute renal failureDoxycyclineEhrlichiaEhrlichiosisFeversHepatitisPneumonitisRocky Mountain spotted feverRural areasTicks ePublished: 15 August 2000 Issue Published: 1 May 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
NATURAL HISTORY OF THE KUMBH FAIR CHOLERA OUTBREAKS.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AL-ANON
Authors: M. Anthony
Journal: JAMA (1977)

AL-ANON is a self-help program for the spouse, family, and friends of the alcoholic. The 12 steps of Alcoholics Anonymous (AA) are used as their guide for growth. "The sole qualification for membership is that their lives have been or are being deeply affected by close contact with an alcoholic."<sup>1</sup> Ten million Americans are alcoholics. For every alcoholic, at least four others are intimately affected by this disease, primarily the spouse and family of the alcoholic. That means the lives of 40 million men, women, and children are scarred by alcoholism: 40 million reacting to the insane behavior of the alcoholic; 40 million angry, resentful, guilt-ridden, anxiety-ridden people, living from one crisis to another, 50 million sick people. Alcoholism is truly a family illness. <h3>How Does the Family Become So Sick?</h3> In my case, 11 years passed from our marriage (the beginning of our problems) until Helen's introduction into
Abstract 410: Quantification and downstream analysis of circulating tumor cells isolated using CapioCyteTM liquid biopsy
Authors: Michael J. Poellmann, Jiyoon Bu, Dominic Moon, Kyle Wagner, Andrew Z. Wang, Seungpyo Hong
Journal: Cancer Research (2019)

Abstract Background: Circulating tumor cells (CTCs) have great potential as biomarkers for the diagnosis and prognosis of many cancers. The CapioCyteTM chip isolates live CTCs through a unique combination of biomimetic cell rolling and nanoparticle-mediated multivalent immunorecognition. Recently-published work reported the highly sensitive and specific CTC capture from 24 patients in a pilot study [Myung et al., Clinical Cancer Research 2018, 24(11):2439-2547]. Here, we report results from additional cohorts of patients and demonstrate downstream analysis of captured CTCs. Methods: Peripheral blood samples were collected from patients undergoing radiotherapy (RT) (n=12; oligometastic n = 5, head and neck cancer n = 1, non small cell lung cancer n = 2, prostate cancer n = 3, cervical cancer n = 1) or immunotherapy (n=4). Samples were processed the next day by CapioCyteTM chips designed for the immunoisolation cells expressing epithelial cell adhesion molecule (EpCAM), human epidermal growth factor-2 (HER-2), and epidermal growth factor receptor (EGFR). Captured CTCs were identified by immunocytochemistry as containing round nuclei, positive expression of cytokeratin, and negative expression of CD45. Select samples were recovered from the capture surface and submitted for single cell gene expression assays (RNASeq) using 10X Genomics Chromium barcoding and Illumina next-generation sequencing. Results: Immunocytochemical staining identified CTCs in all pre-treatment blood samples from patients undergoing RT (mean 95 CTC/ml whole blood, SE 54, range 4-680) and immunotherapy (mean 70 CTC/ml whole blood, SE 16, range 39-104). CTC counts decreased with time points collected during and post-treatment, consistent with other measures of treatment progress. Single cell RNASeq confirmed the presence of tumor-derived cells in select samples and, importantly, demonstrated the ability to conduct downstream analysis of CTCs isolated on the CapioCyteTM chip. Conclusions: The CapioCyteTM chip effectively captures CTCs for quantification and downstream analysis requiring viable cells such as RNASeq. The liquid biopsy technology has great potential to contribute to diagnosis and personalized treatment of cancer. Citation Format: Michael J. Poellmann, Jiyoon Bu, Dominic Moon, Kyle Wagner, Andrew Z. Wang, Seungpyo Hong. Quantification and downstream analysis of circulating tumor cells isolated using CapioCyteTM liquid biopsy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 410.
Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice
Authors: Lissandra Castellan Baldan, Kyle A. Williams, Jean-Dominique Gallezot, Vladimir Pogorelov, Maximiliano Rapanelli, Michael Crowley, George M. Anderson, Erin Loring, Roxanne Gorczyca, Eileen Billingslea, Suzanne Wasylink, Kaitlyn E. Panza, A. Gulhan Ercan-Sencicek, Kuakarun Krusong, Bennett L. Leventhal, Hiroshi Ohtsu, Michael H. Bloch, Zoë A. Hughes, John H. Krystal, Linda Mayes, Ivan de Araujo, Yu-Shin Ding, Matthew W. State, Christopher Pittenger
Journal: Neuron (2014)
Comparison of incidence and survival outcomes in mucinous and signet-ring cell colorectal cancers with classical adenocarcinoma: A SEER analysis
Authors: T. Mehmood
Journal: Annals of Oncology (2018)

Introduction: Besides classical adenocarcinoma (AC), mucinous adenocarcinoma (MAC) and signet-ring cell carcinoma (SRCC) are less frequent subtypes of colorectal cancer, and their recent epidemiologic data are lacking. The current study was designed to explore the evolving epidemiology and prognosis of patients with colorectal MAC and SRCC, compared with AC. Methods: The Surveillance, Epidemiology and End Results (SEER) registry database was adopted for patients with pathologically confirmed colorectal neoplasms as their first malignancy. Incidence and survival trends were estimated by age and histologic subtype. 5-year cancer specific survival (CSS) were evaluated for entire cohort, and compared in subgroups by age, grade and stage. Multivariate analysis of CSS was conducted for entire cohort. Results: MAC incidence (per 100,000) declined slightly from 6.1 in 1975 to 5.6 in 2001, and fell to 2.5 in 2012 with an APC of -7.8% (95%CI=-8.8%–6.8%, P < 0.001), then reached a plateau. SRCC incidence gradually climbed from 0.1 in 1975 to 0.6 in 1999 with an APC of 8.3% (95%CI=7.2%-9.4%, P < 0.001) and went down to 0.4 in 2014 with an APC of -3.0% (95%CI=-5.0%–1.0%, P < 0.001). Among patients younger than age 50 years, MAC incidence decreased at an APC of -2.6% (95%CI: -3.6%–1.6%, P < 0.001), and SRCC remained stable, whereas AC incidence increased greatly at an APC of 1.9% (95%CI: 1.6%-2.2%, P < 0.001). Survival of both MAC and AC increased over time, while the survival of SRCC fluctuated without evident improvement. The 5-year CSS of SRCC was 31.3%, significantly lower than AC (66.6%) and MAC (60.4%). For AC and MAC Survival rate of patients aged below 50 years was superior to those aged 50 years or over through time, while in SRCC, after follow-up of approximately 20 months, the survival rate of younger patients dropped and became lower than older patients. Histologic subtype was an independent factor for CSS of CRC. Conclusion: The incidence and survival of colorectal MAC and SRCC differs from traditional AC. Despite of the low incidence of SRCC, the survival is significantly worse than AC and MAC, especially for patients aged younger than 50 years. Further studies of the etiologies and treatment for rare subtypes of CRC are needed.
Coalition seeks drop in hypertensive disorders
Authors: C. Marwick
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal