tbuckley/cabot-search huggingface dataset:
Asbestos removal, health hazards, and the EPA. Council on Scientific Affairs, American Medical Association
Journal: JAMA (1991)

Resolution 193 (A-90), which was adopted by the House of Delegates of the American Medical Association, called on the Council on Scientific Affairs to study the situation regarding asbestos abatement, the risks to health, and the appropriateness of Environmental Protection Agency regulations, policies, and control measures. This report reviews the current status of asbestos abatement as applied to schools and public buildings, which currently accounts for the major expenditure of public funds. (<i>JAMA</i>. 1991;266:696-697)
Correction
Journal: BMJ (1959)

I well remember that, early in 1948, Mr. Aneurin Bevan told us, "The great thing is to get the Service started, and we can discuss remuneration afterwards," and, with the pistol at our heads, we had to comply or lose everything.Well, we appear to have been discussing remuneration ever since, and nothing much has been settled yet.Let us not make another such blunder on the subject of this particular scheme.
Sinusoidal Obstruction Syndrom (SOS): Warning about Autologous Stem Cell Transplantation (ASCT) Preceded By Regimens Containing Oxaliplatin
Authors: Pierre-Edouard Debureaux, Delphine Le Febvre de Nailly, Emmanuelle Tavernier, Manel Bedoui, Frederique Kuhnowski, Jerome Tamburini, Luc Mathieu Fornecker, Herve Tilly, David Sibon, Marie-Pierre Moles, Sylvie Glaisner, Jean Philippe Richardet, Sebastien Mule, Julien Calderaro, Corinne Haioun, Jehan Dupuis
Journal: Blood (2018)
Workshop on European behavioural indications for men who have sex with men
Authors: Collective Editorial team
Journal: Eurosurveillance (2008)

HIV and sexually transmitted infections (STI) reported among men having sex with men (MSM) have risen in western Europe in recent years. This is thought to be a result of unsafe sexual practices, but data in this field are lacking. Many European Union (EU) Member States conduct surveys or hand out questionnaires about sexual behaviour and attitudes, either to patients visiting STI clinics, or in at-risk communities, such as MSM. However, the methods of such behavioural surveillance vary greatly between countries, making it difficult to compare data and obtain an overall view of the current sexual behaviour and attitudes in the EU.
Constraints on consultants.
Journal: BMJ (1973)

Constraints on ConsultantsThe consultant's right alone to decide on the line of treat- ment for his patients is fundamental to the concept of medi- cine as a profession, so that any suggestion that this right might need qualification deserves the most careful examina- tion.This is, however, the major issue raised by the report' of the investigation into medical and nursing practices at Napsbury Hospital published last week.Sadly, medical men have become only too familiar with investigations into ill treatment and neglect in mental hospitals; but this latest inquiry had nothing to do with brutal nurses assaulting patients.Instead it was concerned with complaints that arose from a philosophy of treatment introduced at the hospital, undoubtedly carried out with the best possible motivation and with enthusiasm and dedication, but one which never- theless caused grave disquiet both within the hospital and among patients' relatives outside it.Napsbury Hospital is a traditional asylum, standing in well-kept and beautiful grounds, and looking after 1,300 patients.The inquiry was concerned with only a small part of the hospital, that run by one of the consultant psychiatrists, Dr. R. D. Scott.In the late 1960s he introduced a new approach to the treatment of patients with schizo- phrenia based on the concept that their mental state was the result of a crisis in family or interpersonal relationships and that involving patients and their fqmilies in confrontation situations could lead to better understanding and prepare the patient for return to life in the community.The aim of treatment was progressively to hand back to the patient the responsibility surrendered at his admission.This implied withdrawal of conventional nursing care, so that patients were expected to make their own beds, wash their dishes, serve their own meals, and to keep the ward clean.Almost all the complaints made about the hospital were concerned with consequences of this therapeutic approach-"alleged dirty and unhygienic conditions, broken windows, neglect of patient-care, abrupt withdrawal of drug therapy leading to deterioration, and harsh attitudes by medical nursing staff towards patients and their relatives.Other complaints were made that patients who appeared to need further hospital care were either refused admission or discharged from hos- pital; relatives were refused interviews with the doctors unless the patient was also present, and abrasive confrontations took place between patients, relatives and staff."Many of the nurses and doctors in other parts of the hospital were unhappy a-bout the treatments used in Dr.
Abstract 3832: Mir429 Regulates NO-dependent Differentiation Of Mouse Embryonic Stem Cells
Authors: Jessica Rosati, Francesco Spallotta, Sara Vincenti, Diego Arcelli, Carlo Presutti, Maurizio C Capogrossi, Carlo Gaetano, Barbara Illi
Journal: Circulation (2008)

BACKGROUND: microRNAs (miRs) are emerging as important regulators of many cell functions and, possibly, also embryonic stem cells (ES) differentiation. Recently, it has been shown that specific microRNAs may allow ES to discriminate among different developmental lineages. Nitric oxide is a key regulator of vascular function and induces cardiogenesis in embryonic stem cells; however, no data are available about the effect of NO on microRNAs expression patterns, neither in adult nor in stem cells. METHODS AND RESULTS: mouse ES were deprived of Leukemia Inhibitory Factor (LIF) and treated with the NO donor diethylenetriamine nitric oxide adduct (DETA/NO) for 90 minutes and microRNA microarray analysis was performed. Among the differentially expressed microRNAs, we focused on miR429, belonging to the miR200 mirRNA family, which regulates epithelial to mesenchymal transition, targeting ZEB transcription factors. ES cells (5x10 5 ) were exposed from 90 minutes to 24 hours to DETA/NO in the absence of LIF and real time PCR experiments, were performed. We found that miR429 progressively increased along the whole time course, in the presence of DETA/NO, to be upregulated 8 fold with respect to control cells at the 24 hours time point. Moreover, we found that, consistently with miR429 upregulation, NO treatment down-modulated ZEB2/Sip1 transcription factor expression in ES cells. Both antagomir429 and ZEB2/Sip1 overexpression blocked NO-dependent expression of cardiovascular markers, such as Flk-1 and SM22α, in ES, while inducing ES proliferation, indicating the mir429/ZEB circuitry as an important regulator of ES cell fate. To our knowledge, these data identify the first, NO-dependent, microRNA-based mechanism regulating ES development and indicate ZEB2/Sip1 as a novel, potential “stem” gene.
THE ALLEGED DECREASING LONGEVITY.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Poetry and Medicine
Authors: Jon Mukand
Journal: JAMA (1990)

"Coma" by Beth Bentley is reprinted by permission of the poet. The poem is included in Mukand J, ed: Sutured Words: Contemporary Poetry About Medicine (Brookline, Mass: Aviva Press [PO Box 1357]; 1987) and appeared in Country of Resemblances (Athens: Ohio University Press; 1976).
Plasma-Based Genotyping Pays Off in NSCLC
Journal: Cancer Discovery (2018)

A recent study showed that plasma-based genotyping of circulating tumor DNA from patients with metastatic non-small cell lung cancer detected clinically relevant targetable driver and resistance mutations in roughly one third of cases, whether used alone or in combination with sequencing data from tumor tissue. This means that liquid biopsies are a valid clinical option for many patients. In addition, more than 85% of patients who received targeted treatment based on the liquid biopsy findings experienced a complete or partial response or stable disease.
The Melatonin Hypothesis: Electric Power and Breast Cancer
Authors: Richard G. Stevens, Scott Davis
Journal: Environmental Health Perspectives (1996)

Breast cancer is a disease of modern life.As societies industrialize, risk increases, yet it is unclear which of the myriad changes coming with industrialization drives this increase.One important hallmark of modern life is the pervasive use of electric power.Electric power produces light at night (LAN) and electric and magnetic fields (EMF), either or both of which may alter pineal function and its primary hormone melatonin, thereby, perhaps increasing the risk of breast cancer.This hypothesis, stated a decade ago, is now receiving considerable experimental and epidemiological attention.The circumstantial case for the hypothesis has three aspects: light effects on melatonin, EMF effects on melatonin, and melatonin effects on breast cancer.The strongest of these aspects is the effects of light on melatonin.It is clear that the normal nocturnal melatonin rise in humans can be suppressed by light of sufficient intensity.The evidence for an effect of melatonin on breast cancer in experimental animals is strong, but the evidence in humans is scant and difficult to gather.The weakest aspect of the circumstantial case is EMF effects on melatonin.Whereas a half dozen independent laboratories have published findings of suppression in animals, there are inconsistencies, and there are no published data on humans.The direct evidence bearing on the hypothesis is sparse but provocative.Two laboratories have published data showing substantial increases in chemically induced breast cancer in rats by a weak AC (alternating current) magnetic field.The epidemiological evidence is very limited but has offered some support as well.An effect of electric power on breast cancer would have profound implications, and this possibility deserves continued investigation.
Long-Range Transport Modeling of Air Pollution Episodes
Authors: Frank A. A. M. de Leeuw, H. Jetske van Rheineck Leyssius
Journal: Environmental Health Perspectives (1989)

The air quality network in the Netherlands is based on a regular grid with an interstation distance of 30 to 40 km. In or close to source areas, a higher station density is realized. Atmospheric transport models form an intrinsic part of the air quality monitoring system. The models are constructed in such a way that only routinely available meteorological input data are needed. The models are applied for interpretation and generalization of the measurements in terms of contributions of source categories. In scenario studies, the potential effect of abatement strategies is explored. The output of the models consists of concentration and deposition fields of NOx, NO2, SO2, sulfate, and nitrate on the scale of the Netherlands or on the scale of northwestern Europe. In the present version the models are not directly suitable to estimate exposures to acidic aerosols; however, in combination with limited aerosol measurements, the model predictions can be used to provide information on the spatial and temporal distribution of acidic aerosols as needed for exposure assessment.
Psychiatry and Eugenics
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Capnocytophaga speciesand preterm birth Case Series and Review of the Literature
Authors: Emmanuel LOPEZ, Josette RAYMOND, Juliana PATKAI, Mayass EL AYOUBI, Thomas SCHMITZ, Guy MORIETTE, Pierre-Henri JARREAU
Journal: Clinical Microbiology and Infection (2009)

<h2>Abstract</h2> <i>Capnocytophaga</i>, a genus of Gram-negative anaerobes that inhabit the oral cavity, has been reported to be an unusual cause of chorioamnionitis and neonatal infection. We report five cases of <i>Capnocytophaga</i> spp. infections in preterm infants (one proven infection and four probable infections) and review 14 previously reported cases. We suggest that <i>Capnocytophaga</i> sp. may be responsible for some occult causes of chorioamnionitis or preterm birth, and that the prevalence of this infection may be higher than previously reported.
Table of Contents
Authors: Christina Wyatt, Glenn Chertow, Kisha Sivanathan, Patrick Coates, Alexander Rosenkranz, Philip Kalra, Darren Green, Dimitrios Poulikakos, David Waters, Liffert Vogt, Roy Mathew, Sripal Bangalore, Mandeep Sidhu, Jerome Fleg, Franklin Maddux, Ingeborg Bajema, Suzanne Wilhelmus, Charles Alpers, Jan Bruijn, Robert Colvin, H Cook, Vivette D'agati, Franco Ferrario, Mark Haas, J Jennette, Kensuke Joh, Cynthia Nast, Laure-Hélène Noël, Emilie Rijnink, Ian Roberts, Surya Seshan, Sanjeev Sethi, Agnes Fogo, Dearbhla Kelly, Paul O'hara, Eoin Kelleher, Liam Casserly, Uremic Cranial Neuropathy, Januvi Jegatheswaran, Carlos Torres, Edward Clark, Amin Oomatia, Peter Dupont, Paul Bass, Shabir Moochhala
Journal: Kidney International (2018)
Cholera
Authors: J. Bird
Journal: BMJ (1849)

patient's complaint, I at once resolved to apply two galvanic batteries of the size of a shilling eacb, above the seat of mischief, immediately over the spine, in the manner advised in the former case.The aperients were continued, and Donovan's syrup of bark in half-drachm doses, with five minims of dilute bydrocyanic acid, P. L. 1836, was prescribed to be taken twice daily.On the seventh nigbt she complatined of a good deal of pain in the back.To take morphime hydrochlor.gr. 88. at bed- time.In the morning had passed a good night.Eschars forming, covered with a white powder.In twelve days they separated, and were then dressed with savine ointment.From this day my patient became rapidly convalescent, and in a few weeks returned home quite well.I could easily multiply cases of the good effects of counter-irritation judiciously applied.I do not attach much importance to the galvanic action produced by the apparatus, but merely recommend it as being an excellent substitute where the more formidable remedies, such as potassa fusa, moxie, or the potential cautery, may be objected to on ac- count of the suffering they entail, and which in some constitutions is an insuperable bar to their use.
John Murphy (1857-1916), Chicago surgeon
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Changes in Regional Brain Glucose Metabolism Measured With Positron Emission Tomography After Paroxetine Treatment of Major Depression
Authors: S. H. Kennedy
Journal: American Journal of Psychiatry (2001)

OBJECTIVE: Depression is commonly associated with frontal hypometabolic activity accompanied by hypermetabolism in certain limbic regions. It is unclear whether successful antidepressant treatments reverse these abnormalities or create new resting levels of metabolism. The aim of the present study was to assess the effects of successful paroxetine treatment on regional glucose metabolism in patients with major depression. METHOD: Positron emission tomography with [18F]fluorodeoxyglucose was performed on 13 male patients before and after 6 weeks of paroxetine therapy. Resting state scans were also acquired under similar conditions in 24 healthy male subjects for comparison. RESULTS: After successful paroxetine therapy, increased glucose metabolism occurred in dorsolateral, ventrolateral, and medial aspects of the prefrontal cortex (left greater than right), parietal cortex, and dorsal anterior cingulate. Areas of decreased metabolism were noted in both anterior and posterior insular regions (left) as well as right hippocampal and parahippocampal regions. In comparison to metabolism levels in a group of healthy volunteers, the increase in prefrontal metabolic activity represented a normalization of previously reduced metabolic activity, whereas the reduction in pregenual anterior cingulate activity represented a decrease from previously elevated metabolic levels. CONCLUSIONS: These results provide further support for a dysfunction in cortical-limbic circuitry in depression, which is at least partly reversed after successful paroxetine treatment.
William Cobbett, Benjamin Rush, and the death of General Washington
Authors: N. E. Davies
Journal: JAMA (1983)

GEORGE Washington's death on Dec 14, 1799, ended a tumultuous century in the history of the United States. With a finality that equaled the signing of the Declaration of Independence or Cornwallis' surrender at Yorktown, the church bells tolling Washington's death rang out the order of things as they had been for almost two centuries. <h3>Washington's Last Illness</h3> Although large and robust, Washington had numerous illnesses during his life, including bouts with smallpox and pneumonia, recurrent diarrhea, a large thigh abscess, and many dental problems.<sup>1</sup>His final illness was mercifully short. After riding about his plantation in the freezing rain on Thursday, Dec 12, he contracted an upper respiratory tract infection with hoarseness developing on the following day. On Friday he went outdoors for a short time and in the evening read the newspapers aloud to his wife. Sometime between 2 and 3 AM on Saturday, the 14th, he awakened
Abstract P208: Mortality Trends 1987 to 2004 in 404,480 Hospitalized Heart Failure Patients with and without Diabetes
Authors: Lena M Bjorck, Michailis Lanitis, George Lappas, Masuma Novak, Annika Rosengren
Journal: Circulation (2012)

Introduction and Aim: To investigate the influence of diabetes on trends in 3-year survival in patients hospitalized with heart failure (HF). Method: The Swedish Hospital Discharge and Cause of Death Registers were used to estimate age and gender-specific trends in 3-year case-fatality in 404,480 patients hospitalized with HF in 1987 to 2004, among whom 73,153 (18%) had diabetes. Results: 3-year case-fatality was 28% higher among HF patients with diabetes compared to non-diabetics (age- and sex-adjusted HR 1.28, 95% CI 1.26-1.29). Overall, case-fatality among men with HF aged &lt; 65 years decreased by more than half and among men aged 65 years and older by 30%, irrespective of the presence of diabetes. Women aged 65 and over with diabetes also displayed a decrease of 30%, whereas there was a leveling off in survival after the mid-90s among women without diabetes, such that the difference in survival between diabetic and non-diabetic women decreased. Conclusions: 3-year mortality in patients with HF decreased more for younger, compared to older individuals and more for men than women. Coexistence of diabetes did not influence the trends in outcome adversely, with continuing improvement in prognosis also for heart failure patients with diabetes.
Life-threatening drug eruptions
Authors: A. Rostenberg
Journal: JAMA (1965)

Most drug eruptions seen by the physician are of mild or moderate severity and cause no threat to life or subsequent health. However, severe reactions can develop, and a small proportion of these may be life-threatening. Before discussing specific drug eruptions, we should like to discuss the proof of a causal relationship between a given drug and an eruption. It is difficult to prove the precise etiologic agent for any suspected eruption. The only way to prove definitively that a given drug has caused an eruption is to discontinue the suspected drug, wait until the reaction clears, and then readminister the drug to observe if a relapse occurs. If the condition improves and ultimately clears entirely when the drug is withdrawn, and reappears when the drug subsequently is readministered, the drug may be regarded as the causal agent. However, readministering the suspected drug is very hazardous, and<i>we must emphasize</i>
Prolonged coma after acetohexamide ingestion
Authors: D. L. Cowen
Journal: JAMA (1967)

<h3>To the Editor:—</h3> Acetohexamide is a relatively new oral hypoglycemic agent whose side effects following an excessive dose are still being evaluated. Consumption of acetohexamide as a suicidal agent has not been reported in the literature. A case of protracted coma introduced by the ingestion of a large quantity of acetohexamide in a suicide attempt by a young, healthy, nondiabetic person is presented. <h3>Report of a Case:—</h3> A 16-year-old Spanish-American girl was seen in the Denver General Hospital emergency room on Sept 27, 1966, at 10:30 PM, with a history of ingestion of an unknown quantity of unknown substance. The patient was lethargic but responsive. Findings from the physical examination were otherwise normal. Administration of ipecac produced emesis. Following oral administration of 30 cc of magnesium sulfate solution, the patient was discharged to her parents. The patient was readmitted at 6:50 PM on Sept 28, with a history of recent