tbuckley/cabot-search huggingface dataset:
Impaired Cognitive Function in Immune-TTP Is Better Predicted By Serum Thrombomodulin Than ADAMTS13 Activity: Results of a Longitudinal Multicenter Pilot Study
Authors: Aaron Boothby, Michael D Evans, Shangbin Yang, Senthil Sukumar, James G Scott, Deirdra Terrell, Spero Cataland, Marshall Mazepa
Journal: Blood (2023)
Bortezomib-Cyclophosphamide-Dexamethasone (VCD) Vs Bortezomib-Lenalidomide-Dexamethasone (VRD) in Newly Diagnosed Multiple Myeloma: A Matched Real-World Analysis from the Balkan Myeloma Study Group (BMSG)
Authors: Efstathios Kastritis, Meral Beksac, Sorina Nicoleta Badelita, Eirini Katodritou, Jelena Bila, Emmanouil Spanoudakis, Guldane Cengiz Seval, Zorica Cvetkovic, Olivera Markovic, Selami Kocak Toprak, Dimitra Dalampira, Daniel Coriu, Zoi Bezirgiannidou, Mario Pirsic, Toni Valkovic, Iulia Ursuleac, Aleksandra Sretenovic, Angeliki Sevastoudi, Josip Batinic, Sinziana Barbu, Maria Roussou, Maria Gavriatopoulou, Evangelos Terpos, Meletios A. Dimopoulos
Journal: Blood (2023)
ASXL1 Truncating Mutations Drive Leukemic Resistance to T Cell Attack
Authors: Dustin McCurry, Zhongqi Ge, Jaehyun Lee, Pranaya Raparla, Thomas Koehnke, Rishi Pasumarthi, Xiaohong Leng, Oren Pasvolsky, Vinhkhang Nguyen, Katie Maurer, Shuqiang Li, Kenneth J. Livak, Elham Azizi, Robert J. Soiffer, Sachet Shukla, Ravindra Majeti, Jerome Ritz, Catherine J Wu, Jeffrey J. Molldrem, Pavan Bachireddy
Journal: Blood (2023)
Efficacy and Safety of Daratumumab (DARA) Monotherapy in Patients with Intermediate-Risk or High-Risk Smoldering Multiple Myeloma (SMM): Final Analysis of the Phase 2 Centaurus Study
Authors: Ola Landgren, Ajai Chari, Yael C. Cohen, Andrew Spencer, Peter M. Voorhees, Irwindeep Sandhu, Matthew W. Jenner, Dean Smith, Michele Cavo, Niels WCJ van de Donk, Meral Beksac, Philippe Moreau, Hartmut Goldschmidt, Linlin Sha, Liang Li, Els Rousseau, Robyn Dennis, Robin Carson, Craig C. Hofmeister
Journal: Blood (2023)
Utility of the Platelet Function Analyzer (PFA-100) in Patients with Bleeding Disorder of Unknown Cause
Authors: Dino Mehic, Jasmin Sabrina Rast, Michelle Fuchs, Alexander Tolios, Beate Eichelberger, Alexandra Kaider, Cihan Ay, Ingrid Pabinger, Johanna Gebhart
Journal: Blood (2023)
LAMP5 Is an AML-Restricted Immunotherapeutic Target Enriched in High-Risk Acute Myeloid Leukemia
Authors: Nika Panahi, Tiffany Hylkema, Grace Hawkins, Makia K Manselle, Jack H Peplinski, Logan K Wallace, Rhonda E Ries, Soheil Meshinchi, Danielle C Kirkey
Journal: Blood (2023)
The Modified Melphalan-Cladribine-Busulfan-Cyclophosphamide (MCBC) Conditioning Regimen Improved Relapse-Free Survival after Allo-HSCT in Refractory/Relapsed AML
Authors: Xiaoyu Zhang, Shulian Chen, Weihua Zhai, Yi He, Sizhou Feng, Mingzhe Han, Ting Niu, Yajing Xu, Guangxun Gao, Shengjin Fan, Zepin Zhou, Fang Zhou, Rui Xi, Li Liu, Wei Yang, Xi Zhang, Qifa Liu, Erlie Jiang
Journal: Blood (2023)
Development of Syngeneic Murine Cell Lines of Germinal Center-Derived B-Cell Lymphomas
Authors: Henna S. Nam, Yusuke Isshiki, Min Xia, Sanket Shah, Meng Li, Ioannis Karagiannidis, Matthew Teater, Ari M Melnick, Wendy BÃ©guelin
Journal: Blood (2023)
Efficacy and Safety of Human Umbilical Cord-Derived Mesenchymal Stem Cells in the Treatment of Immune Thrombocytopenia: A Prospective, Single Centre, Single Arm, Phase I Trial
Authors: Yunfei Chen, Xu Yanmei, Yuchen Gao, Ying Chi, Ting Sun, Xueqing Dou, Zhibo Han, Feng Xue, Huiyuan Li, Wei Liu, Xiaofan Liu, Huan Dong, Rongfeng Fu, Mankai Ju, Xinyue Dai, Wentian Wang, Yueshen Ma, Zhen Song, Jundong Gu, Wei Gong, Renchi Yang, Lei Zhang
Journal: Blood (2023)
Efficacy of D-RVD Vs RVD Among t(11;14) Patients with Newly Diagnosed Myeloma
Authors: Jonathan L. Kaufman, Nisha S. Joseph, Vikas A. Gupta, Sara Dicamillo, Danielle Roberts, Craig C. Hofmeister, Madhav V. Dhodapkar, Ajay K. Nooka, Sagar Lonial, Lawrence H. Boise
Journal: Blood (2023)
An Analytic Framework for the Prediction of Gvl Minor Histocompatibility Antigens to Prevent or Treat Post-Transplant Relapse
Authors: Nicoletta Cieri, Liang Li, Nidhi Hookeri, Kari Stromhaug, Julia Keating, Jonathan Stevens, Kameron Kooshesh, Helen Ji, Gabrielle M. Hernandez, Jennifer Abelin, Susan Klaeger, Cleo Forman, Karl Clauser, Siranush Sarkizova, Giacomo Oliveira, Livius Penter, Haesook T. Kim, William Lane, Shuqiang Li, Kenneth J. Livak, Steven A. Carr, Derin B. Keskin, Vincent T. Ho, Jerome Ritz, Robert J. Soiffer, Donna S. Neuberg, Chip Stewart, Gad Getz, Catherine J Wu
Journal: Blood (2023)
Increased Circulating Levels of YKL-40 Protein in Children and Adolescents with Hemophilia: Correlation with the Degree of Hemophilic Arthropathy
Authors: Aikaterini Michalopoulou, Aimilia Mantzou, Athina Dettoraki, Zoey Kapsimali, Christina Kanaka-Gantenbein, Ioannis Papassotiriou, Helen Pergantou
Journal: Blood (2023)
The Correlation of Muscle Mass and Walking Distance with Joint Health and Functional Status in Hemophilic Arthropathy Among People with Hemophilia a (PwHA)
Authors: Chia-Yau Chang, Jia-Pei Hong, Chian-Her Lee, Shu-Huey Chen, Yen-Lin Liu, Yeu-Chin Chen, Jia-Ruey Tsai, Chen-Hua Tsai, Wan-Ling Ho, Chih-Hong Lee, Jiunn-Horng Kang
Journal: Blood (2023)
One-Stop No-Edited Allogenic CAR-T Therapy Bridging HSCT to Treat Children with Relapse and Refractory Acute Lymphoblastic Leukemia: A Prospective Clinical Study from a Single Center
Authors: Chengjuan Luo, Yanjing Tang, Changying Luo, Xiaohang Huang, Xia Qin, Hua Zhu, Benshang Li, Jing Chen
Journal: Blood (2023)
Fixed Duration Mosunetuzumab Plus Polatuzumab Vedotin Has Promising Efficacy and a Manageable Safety Profile in Patients with BTKi Relapsed/Refractory Mantle Cell Lymphoma: Initial Results from a Phase Ib/II Study
Authors: Michael L. Wang, Sarit Assouline, Manali Kamdar, Nilanjan Ghosh, Seema Naik, Shazia K. Nakhoda, Julio C. Chavez, Ting Jia, Song Pham, Ling-Yuh Huw, Jing Jing, Wahib Ead, Iris To, Connie Lee Batlevi, Michael C. Wei, L. Elizabeth Budde
Journal: Blood (2023)
Validity, Reliability, and Feasibility of Smartphone Application Intended for Home Measurement of Gait Speed and Other Gait Dynamics in Older Adults with Blood Cancers
Authors: Pei-An Lee, Clark Dumontier, Wanting Yu, Kristi T Ho, Nicholas Groblewski, JunHong Zhou, Thomas Travison, Marcia Testa, Tammy Hshieh, Dae Kim, Jane A Driver, On-Yee Lo, Brad Manor, Gregory A Abel
Journal: Blood (2023)
T-Cell Signaling Mediates the Epigenetic Priming of Germinal Center B-Cell Plasticity and Stem Functionality
Authors: Laurianne Scourzic, Franco Izzo, Lucretia Cucereavii, Matthew Teater, Alexander Polyzos, Christopher Chin, Coraline Mlynarczyk, Ioanna Tsialta, Robert M Myers, Wendy BÃ©guelin, Matthias Stadtfeld, Zhengming Chen, Dan A. Landau, Ari M Melnick, Eftychia Apostolou
Journal: Blood (2023)
Inferred Gene Expression By Cell-Free DNA Profiling Allows Noninvasive Lymphoma Classification
Authors: Jurik A Mutter, Mohammad Shahrokh Esfahani, Joseph Schroers-Martin, Stefan K. Alig, Mark P. Hamilton, Brian J. Sworder, Benoit Tessoulin, Jan Boegeholz, Timothy Flerlage, Jamie E. Flerlage, Michael S. Binkley, Takeshi Sugio, Cédric Rossi, Mari Olsen, Chih Long Liu, Steven Le Gouill, David M. Kurtz, Maximilian Diehn, Ash A. Alizadeh
Journal: Blood (2023)
Efficacy and Safety of the Anti-Tissue Factor Pathway Inhibitor Marstacimab in Participants with Severe Hemophilia without Inhibitors: Results from the Phase 3 Basis Trial
Authors: Davide Matino, Suchitra Acharya, Andrew Palladino, Eunhee Hwang, Regina McDonald, Carrie Turich Taylor, John Teeter
Journal: Blood (2023)
Impact of Antibacterial Prophylaxis on Morbidity-Mortality of Patients with Myeloid Neoplasms Treated with Non-Intensive Venetoclax Combinations
Authors: Sara Garrido Paniagua, Sandra Novoa Jáuregui, Antonieta Molero Yordi, Ferran Vall-llovera Calmet, Laura Camila Valencia Becerra, Cristian Escolano Escobar, Irene Arnaiz Martín, Raquel Ocampo Martínez, Elena Masana Flores, Clara Isabel González-Santillana, Alfredo Pacheco Reyes, Raquel Capellán García, Marta Aceituno Caneiro, Rosa Coll, Adaia Albasanz-Puig, Isabel Ruiz Camps, Carla Alonso-Martínez, Ana Pérez-González, Maria Sola Soto, Maria Laura Fox, David Valcarcel, Olga Salamero
Journal: Blood (2023)
Efficacy of Frontline Treatment with Initial Low-Dose Tyrosine-Kinase Inhibitors in Elderly Patients with Chronic Myeloid Leukemia: A “Campus CML” Study
Authors: Cristina Bucelli, Isabella Capodanno, Maria Cristina Miggiano, Francesco Cavazzini, Sabrina Leonetti Crescenzi, Sabina Russo, Ida Carmosino, Mario Annunziata, Federica SORA, Massimiliano Bonifacio, Luigiana Luciano, Giovanni Caocci, Giuseppina Loglisci, Chiara Elena, Francesca Lunghi, Rikard Mullai, Imma Attolico, Gianni Binotto, Elena Crisa', Paolo Sportoletti, Ambra Di Veroli, Anna Rita Scortechini, Anna Paola Leporace, Alessandro Maggi, Monica Crugnola, Fabio Stagno, Rosaria Sancetta, Pamela Murgano, Davide Rapezzi, Debora Luzi, Jolanda Donatella Vincelli, Sara Galimberti, Monica Bocchia, Carmen Fava, Alessandra Malato, Elisabetta Abruzzese, Giuseppe Saglio, Giorgina Specchia, Massimo Breccia, Alessandra Iurlo, Mario Tiribelli, Roberto Latagliata
Journal: Blood (2023)
Emicizumab Prophylaxis for the Treatment of Chinese Hemophilia A Patients in the Real World: A Multi-Center Retrospective Analysis
Authors: Yuan Xu, Ying Wang, Runhui Wu, Changcheng Zheng, Jianwen Xiao, Weiqun Xu, Xiaoqin Feng, Hua Wang, Xiangshan Cao, Liya He, Tianyang Xue, Mingwei Jin, Bingshou Xie, Jing Ling, Lirong Sun, Rui Su, Hongbo Cheng, Yongjun Fang, Bai Li, Ziqiang Yu, Ailing Xue, Mei Sun, Li Yang, Zeping Zhou, Hu Zhou, Jiao Jin, Min Zhou, Rong Chen, Wei Liu, Lei Zhang, Feng Xue, Renchi Yang
Journal: Blood (2023)
Deep Proteomic Analysis Reveals Shared Terminal Mechanisms for Familial Hemophagocytic Lymphohistiocytosis and Lymphoma-Associated Hyperinflammation
Authors: Adi Zoref-Lorenz, Uri Abadi, Ronit Gurion, Alexander Osnis, Joanne Yacobovich, Yehudit Birger, Galit Berger Pinto, Pia Raanani, Arnon Nagler, Shai Dulberg, Asaf Madi, Gilad Itchaki, Martin H. Ellis, Shai Izraeli, Michael B. Jordan
Journal: Blood (2023)
Clinical Implications of <i>TP53</i> Mutations/Allelic State in Patients (Pts) with Myelodysplastic Syndromes/Neoplasms (MDS) Treated with Hypomethylating Agents (HMA)- a Multicenter, Retrospective Analysis from the Validate Database
Authors: Tariq Kewan, Jan Philipp Bewersdorf, Ondrej Blaha, Maximilian Stahl, Najla H Al Ali, Amy E. DeZern, Mikkael A. Sekeres, Hetty E. Carraway, Pinkal Desai, Elizabeth A. Griffiths, Eytan M. Stein, Andrew M. Brunner, Maria L Amaya, Joshua F. Zeidner, Michael R. Savona, Jessica M. Stempel, Namrata Sonia Chandhok, Hunter Cochran, Rahul Ramaswamy, Abhay Singh, Gail J. Roboz, Benjamin Rolles, Eunice S. Wang, Amyah C. Harris, Rory M. Shallis, Zhuoer Xie, Eric Padron, Jaroslaw P. Maciejewski, Matteo Giovanni Della Porta, Rami S. Komrokji, David A Sallman, Amer M. Zeidan
Journal: Blood (2023)
Survival Advantage Associated with Heterozygous Factor V Leiden Mutation in Sars-Cov-2-Infected K18-hACE2 Mice
Authors: Roberto Aiolfi, Jose A. Fernandez, Hiroshi Deguchi, Xiao Xu, Jeanine Ahmed, Miriam Hauer-Jensen, John H. Griffin, Juan Carlos de la Torre, Hartmut Weiler, Laurent O. Mosnier
Journal: Blood (2023)
CRISPR-Based Functional Transcriptomics Defines the Tumor-Dependency and Molecular Determinants of Long Noncoding RNAs in Multiple Myeloma
Authors: Eugenio Morelli, Anil Aktas-Samur, Domenico Maisano, Claire Gao, Na Liu, Vanessa Favasuli, Marcello Turi, Pietro Folino, Mariateresa Fulciniti, Annamaria Gulla, Kenneth C. Anderson, Mehmet K. Samur, Nikhil C Munshi
Journal: Blood (2023)
Paired Analysis from Patients with Myeloma Elucidates Favorable CAR-T Manufacture and Phenotype, Starting from Mobilized Pre-Transplant Apheresis Vs. Non-Mobilized Apheresis after Four Prior Lines
Authors: Ciara Louise L. Freeman, Julieta Abraham Miranda, Meghan Menges, Jerald Noble, Hien Liu, Salvatore Corallo, Albert J Ribickas, Constanza Savid-Frontera, Gabriel De Avila, Omar Castaneda, Jose L. Ochoa-Bayona, Rachid Baz, Doris K. Hansen, Melissa Alsina, Kenneth H. Shain, Taiga Nishihori, Reginald Atkins, Frederick L. Locke
Journal: Blood (2023)
Real-World Analysis of the Underdiagnosis, Clinical Outcomes and Associated Burden of Hematopoietic Stem Cell Transplantation-Associated Thrombotic Microangiopathy (HSCT-TMA) in the United States of America
Authors: Yan Wang, Andrew Rava, Marlene Smuzynski, Bonny Shah, Anusorn Thanataveerat, Imad Al Dakkak, Moh-Lim Ong, Christopher C Dvorak, Vincent Ho
Journal: Blood (2023)
Selected Frailty Testing Can Predict for Risk of Febrile Neutropenia in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplant
Authors: Anup J Devasia, Sahar Khan, Eshetu Atenafu, Harjot Vohra, Frédéric Larose, Donna Reece, Suzanne Trudel, A. Keith Stewart, Sita D. Bhella, Vishal Kukreti, Chloe Yang, Rodger E. Tiedemann, Anca Prica, Monica Monchis, Eugene Leung, Christina Zeglinski, Zubaida Mohamed, Christine Chen
Journal: Blood (2023)
A Prognostic Nomogram Survival Model for Newly Diagnosed Patients with AIDS-Related Diffuse Large B-Cell Lymphoma: A Multicenter Cohort Study in China
Authors: Tao Yang, Yang Liang, Chaoyu Wang, Jun Liu, Yan Wu, Haiyan Min, Yunhong Huang, Guo Wei, Wei Zhang, Min Wang, Xiaoqiong Tang, Zailin Yang, Li Jun, Hui Zhou, Yao Liu
Journal: Blood (2023)
Combination of Liposomal Mitoxantrone, Venetoclax, Homoharringtonine, and Olverembatinib (HQP1351) (MVHO) in Pediatric Patients with Refractory or Relapsed Acute Myeloid Leukemia (AML): Case Series
Authors: Wenting Hu, Zhuo Wang, Changcheng Chen, Shuhong Shen
Journal: Blood (2023)
A Randomized Double-Blind Placebo-Controlled Phase II Multi-Center Study of Inflammation Modification of Canakinumab to Prevent Leukemic Progression of Clonal Cytopenias of Unknown Significance (CCUS): Impact Study
Authors: Uma M. Borate, Kaitlyn M. Dvorak-Kornaus, Qiuhong Zhao, Ann-Kathrin Eisfeld, Bethany L Mundy-Bosse
Journal: Blood (2023)
Conserved and Unique Regulatory Mechanisms of RUNX1 in Hematopoietic Stem/Progenitor Cell Subpopulations in Both Normal Hematopoiesis and FPD/AML Development
Authors: Chen Wang, Yi Zheng, Cuiqing Fan, Zhaowei Tu, Xiongwei Cai, Jianqiang Wu, Gang Huang
Journal: Blood (2023)
Inflammatory Marker Levels, Age, Race and Prior Treatment Burden Independently Predict Delayed Hematologic Recovery after BCMA-Directed CART Therapy in Multiple Myeloma
Authors: Santiago Thibaud, Jerrel Catlett, Saoirse Bodnar, MD Babu Mia, Ajai Chari, Joshua Richter, Hearn Jay Cho, Larysa J Sanchez, Cesar Rodriguez, Adriana C Rossi, Sundar Jagannath, Shambavi Richard, Samir Parekh
Journal: Blood (2023)
Irf5 Expression in Macrophages Contributes to Iron Regulation within Erythromyeloblastic Islands
Authors: Rachel Josselsohn, Anshul Vagrecha, Margaret LaPan, Julien Papoin, Jonah Kamen, Young Min Cho, Riaz Rao, Laurel Romano, Nathan Salomonis, Theodosia A. Kalfa, Lionel Blanc, Betsy J. Barnes
Journal: Blood (2023)
Reconstitution Dynamics and Impact on Clinical Outcomes of Mucosal-Associated Invariant T-Cells in Pediatric Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Federic Galaverna, Sara Flamini, Ilaria Pili, Carmen De Luca, Emilia Boccieri, Francesca Benini, Francesco Quagliarella, Marco Rosichini, Marialuigia Catanoso, Marianna Coccetti, Shirley Genah, Roberto Carta, Francesca Del Bufalo, Valentina Bertaina, Marco Becilli, Daria Pagliara, Mattia Algeri, Pietro Merli, Franco Locatelli, Enrico Velardi
Journal: Blood (2023)
Resolution of Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome (VOD/SOS) with Defibrotide Following HCT in Adult and Pediatric Patients: Pooled Analysis of Defifrance and EBMT PASS Registries
Authors: Mohamad Mohty, Franco Locatelli, Didier Blaise, Regis Peffault De Latour, Hélène Labussière-Wallet, Vian Amber, Virginie Gandemer, Deborah Gutierrez, Nalina Dronamraju, Jean-Hugues Dalle, Micha Srour
Journal: Blood (2023)
Myeloid Derived Suppressor Cell Kinetics in Peripheral Blood Correlate with Efficacy and Toxicity of CAR T Cell Therapy in Relapsed or Refractory B Cell Lymphoma
Authors: David M Foureau, Hamid Ehsan, Fei Guo, Tahj Jones, Ryan W Jacobs, Bei Hu, Tamara K. Moyo, Yifan Pang, Steven I. Park, Lawrence J. Druhan, Ariel Bell, Nilanjan Ghosh
Journal: Blood (2023)
CSF1R Inhibition Promotes Neuroinflammation and Behavioural Deficits during Graft-Versus-Host Disease in Mice
Authors: Rachael C Adams, Dylan Carter-Cusack, Genesis T Llanes, Christopher R Hunter, Janaki Manoja Vinnakota, Marc Ruitenberg, Jana Vukovic, Patrick Bertolino, Kirat K. Chand, Julie A. Wixey, Samuel P Nayler, Geoffrey R Hill, Scott N Furlan, Robert Zeiser, Kelli PA MacDonald
Journal: Blood (2023)
Subcutaneous Epcoritamab Plus Lenalidomide in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma from EPCORE NHL-5
Authors: Irit Avivi Mazza, Won Seog Kim, Po-Shen Ko, Carlos Grande, David Lavie, David Chism, Mostafa Seliem, Edwin E. Jeng, Neha Joshi, Satya Siddani, Wissam Assaily, Mariana Sacchi, Minh Dinh, Abraham Avigdor
Journal: Blood (2023)
Durable Transfusion Independence in Lower-Risk Myelodysplastic Syndrome (LR-MDS) Is Associated with Better Survival: A Population Level Analysis Based on a Large US Health Insurance Claims Database
Authors: Rami S. Komrokji, Nishan Sengupta, Dylan Supina, Shyamala Navada, Ravi Potluri, Rohit Tyagi, Tim Werwath, Zhuoer Xie, Eric Padron, David A Sallman
Journal: Blood (2023)
A Patient-Centric Approach to Sickle Cell Disease Clinical Trials: Integrating Patient Perspectives in the RISE UP Phase 2/3 Trial of Mitapivat for Informed Protocol Design and Associated Patient Community Benefit
Authors: Charles R. Jonassaint, Blaze Armon Eppinger, Dominique Friend, Golie Lorenzo Green, Mia Robinson, Teonna Woolford, DeMitrious Wyant, Janie Davis, Abdulafeez Oluyadi, Ahmar U Zaidi, Holly John, Wally R Smith
Journal: Blood (2023)
One Year Follow-up on the First Patient Treated with Nula-Cel: An Autologous CRISPR/Cas9 Gene Corrected CD34+ Cell Product to Treat Sickle Cell Disease
Authors: David C Shyr, Robert Lowsky, Weston Miller, Mark A. Schroeder, Tonia Buchholz, Kirstin Dougall, Allison Intondi, Alexandra Charles, Josh Lehrer, Ali Bouge, Stacey Wolf, Blair MacDonald, Hena Din, Alana Lerner, Manal Amoury, Sebastien Treusch, Glen Chew, Brian Silva, Haider Mashhedi, Vincent Siu, Ian Perrone, Twaritha Vijay, Aayami Jain, Kristina Krassovsky, William Matern, Premanjali Lahiri, Ryan Rodriguez, Jason Skowronski, Arpit Batish, Dana Margittai, Prachi Wani, Timothy Van Horn, Claudia Flautero, Rosalva Flores, Jade Lee, Keri Tate, Maria-Grazia Roncarolo, Steven Feldman, John DiPersio, Matthew Porteus
Journal: Blood (2023)
Identifying <i>PTPRJ</i> As a Novel Mediator of <i>CEBPA</i>-Mutated AML
Authors: Alexandra Lubin, Catherine Hockings, Yvette Hoade, Lucy Copper, Phoebe Dace, Catherine Zhu, Helen Brown, Ellen Nuttall Musson, Katie-Jo Miller, Elspeth Payne
Journal: Blood (2023)
Clonal Hematopoiesis Associated with Rheumatoid Arthritis
Authors: Emil Hiitola, Juuso Korhonen, Jukka Koskela, Matti Kankainen, Milla Alakuijala, Heidi Kokkonen, Aoxing Liu, Paavo Häppölä, Paula Savola, Tiina Kelkka, Marjatta Leirisalo-Repo, Ritva Peltomaa, Laura Pirilä, Pia Isomäki, Markku Kauppi, Oili Kaipiainen-Seppänen, FinnGen Consortium, Giulio Genovese, Andrea Ganna, Solbritt Rantapää-Dahlqvist, Satu Mustjoki, Mikko Myllymäki
Journal: Blood (2023)
Noncanonical MAVS signaling restrains dendritic cell–driven antitumor immunity by inhibiting IL-12
Authors: Lingling Wu, Xiaochuan Hong, Chao Yang, Yuanqin Yang, Wenwen Li, Lu Lu, Meichun Cai, Dongqing Cao, Guanglei Zhuang, Liufu Deng
Journal: Science Immunology (2023)

Mitochondrial antiviral signaling protein (MAVS)-mediated cytosolic RNA sensing plays a central role in tumor immunogenicity. However, the effects of host MAVS signaling on antitumor immunity remain unclear. Here, we demonstrate that the host MAVS pathway supports tumor growth and impairs antitumor immunity, whereas MAVS deficiency in dendritic cells (DCs) promotes tumor-reactive CD8+ T cell responses. Specifically, CD8+ T cell priming capacity was enhanced by MAVS ablation in a type I interferon-independent, but IL-12-dependent, manner. Mechanistically, loss of the RIG-I/MAVS cascade activated the noncanonical NF-κB pathway and in turn induced IL-12 production by DCs. MAVS-restrained IL-12 promoted cross-talk between CD8+ T cells and DCs, which was licensed by IFN-γ. Moreover, ablation of host MAVS sensitized tumors to immunotherapy and attenuated radiation resistance, thereby facilitating the maintenance of effector CD8+ T cells. These findings demonstrate that the host MAVS pathway acts as an immune regulator of DC-driven antitumor immunity and support the development of immunotherapies that antagonize MAVS signaling in DCs.
AKATSUKI 48-Week Interim Analysis: Emicizumab and Immune Tolerance Induction in People with Hemophilia A and Factor VIII Inhibitors
Authors: Tadashi Matsushita, Nobuaki Suzuki, Chiai Nagae, Azusa Nagao, Masahiko Ando, Yachiyo Kuwatsuka, Daisuke Nosaka, Yui Kyogoku, Tomomi Shimura, Keiji Nogami
Journal: Blood (2023)
High Expressions of Checkpoint Receptors in T Cells Subsets of Myelodysplastic Syndromes Patients with <i> <i>TP53</i> </i> Mutations
Authors: Lingxu Jiang, Xin Huang, Xinping Zhou, Li Ye, Lu Wang, Chen Mei, Liya Ma, Gaixiang Xu, Chao Hu, Ziyang Zhou, Xiaozhen Liu, Yueyuan Han, Zheng Ge, Hongyan Tong
Journal: Blood (2023)
Orthotopic Heart Transplantation Followed By Autologous Stem Cell Transplantation in Patients with Cardiac AL Amyloidosis: Results from a Single Centre Prospective Study
Authors: Harshita Rajasekariah, Georgia McCaughan, Chun Kei Kris Ma, Natasha Gorrie, Samuel Milliken, David Ma, Keith Fay, Barbara Withers, Nada Hamad, Samuel Birch, Anne Keogh, Andrew Jabbour, Christopher Hayward, Peter Macdonald, John Moore
Journal: Blood (2023)
Efficacy and Safety of Prophylaxis with a Plasma-Derived Von Willebrand Factor/Factor VIII Concentrate in Children and Adolescents with Von Willebrand Disease - a Sub-Analysis of Data from the Wil-31 Study
Authors: Robert F Sidonio, Leonid Dubey, Kateryna V Vilchevska, Adlette Inati, Claudia Djambas Khayat
Journal: Blood (2023)
Safety and Efficacy of Tgrx-678, a Potent BCR-ABL Allosteric Inhibitor in Patients with Tyrosine Kinase Inhibitor (TKI) Resistant/Refractory Chronic Myeloid Leukemia (CML): Preliminary Results of Phase I Study
Authors: Qian Jiang, Yanli Zhang, Qiang Wang, Jianyu Weng, Zhenfang Liu, Suning Chen, Li Weiming, Bingcheng Liu, Zhuogang Liu, Yihan Wang, Jingrong Cao
Journal: Blood (2023)
Comparison of the Efficacy between 81 Mg Bid of Aspirin and 162 Mg Od of Aspirin in Splenectomized Thalassemic Patients with Aspirin Resistance
Authors: Thanapon Kaokunakorn, Theera Ruchutrakool, Bundarika Suwanawiboon, Chattree Hantaweepant, Tarinee Rungjirajittranon, Yupa Nakkinkun, Tasneem Binhama, Yingyong Chinthammitr
Journal: Blood (2023)