tbuckley/cabot-search huggingface dataset:
EULAR study group on ‘MHC-I-opathy’: identifying disease-overarching mechanisms across disciplines and borders
Authors: Jonas JW Kuiper, Jörg C Prinz, Efstratios Stratikos, Piotr Kuśnierczyk, Akiko Arakawa, Sebastian Springer, Dillon Mintoff, Ivan Padjen, Russka Shumnalieva, Seçil Vural, Ina Kötter, Marleen G van de Sande, Ayşe Boyvat, Joke H de Boer, George Bertsias, Niek de Vries, Charlotte LM Krieckaert, Inês Leal, Nataša Vidovič Valentinčič, Ilknur Tugal-Tutkun, Hanane el Khaldi Ahanach, Félicie Costantino, Simon Glatigny, Danijela Mrazovac Zimak, Fabian Lötscher, Floor G Kerstens, Marija Bakula, Elsa Viera Sousa, Peter Böhm, Kees Bosman, Tony J Kenna, Simon J Powis, Maxime Breban, Ahmet Gul, John Bowes, Rik JU Lories, Johannes Nowatzky, Gerrit Jan Wolbink, Dennis G McGonagle, Franktien Turkstra
Journal: Annals of the Rheumatic Diseases (2023)

The ‘MHC-I (major histocompatibility complex class I)-opathy’ concept describes a family of inflammatory conditions with overlapping clinical manifestations and a strong genetic link to the MHC-I antigen presentation pathway. Classical MHC-I-opathies such as spondyloarthritis, Behçet’s disease, psoriasis and birdshot uveitis are widely recognised for their strong association with certain MHC-I alleles and gene variants of the antigen processing aminopeptidases ERAP1 and ERAP2 that implicates altered MHC-I peptide presentation to CD8+T cells in the pathogenesis. Progress in understanding the cause and treatment of these disorders is hampered by patient phenotypic heterogeneity and lack of systematic investigation of the MHC-I pathway. Here, we discuss new insights into the biology of MHC-I-opathies that strongly advocate for disease-overarching and integrated molecular and clinical investigation to decipher underlying disease mechanisms. Because this requires transformative multidisciplinary collaboration, we introduce the EULAR study group on MHC-I-opathies to unite clinical expertise in rheumatology, dermatology and ophthalmology, with fundamental and translational researchers from multiple disciplines such as immunology, genomics and proteomics, alongside patient partners. We prioritise standardisation of disease phenotypes and scientific nomenclature and propose interdisciplinary genetic and translational studies to exploit emerging therapeutic strategies to understand MHC-I-mediated disease mechanisms. These collaborative efforts are required to address outstanding questions in the etiopathogenesis of MHC-I-opathies towards improving patient treatment and prognostication.
Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis
Authors: Omer Goldman, Lital N. Adler, Emma Hajaj, Tommaso Croese, Naama Darzi, Sivan Galai, Hila Tishler, Yarden Ariav, Dor Lavie, Liat Fellus-Alyagor, Roni Oren, Yuri Kuznetsov, Eyal David, Rami Jaschek, Chani Stossel, Oded Singer, Sergey Malitsky, Renana Barak, Rony Seger, Neta Erez, Ido Amit, Amos Tanay, Ann Saada, Talia Golan, Tamar Rubinek, Joo Sang Lee, Shay Ben-Shachar, Ido Wolf, Ayelet Erez
Journal: Cancer Discovery (2023)

Abstract Multiple studies have identified metabolic changes within the tumor and its microenvironment during carcinogenesis. Yet, the mechanisms by which tumors affect the host metabolism are unclear. We find that systemic inflammation induced by cancer leads to liver infiltration of myeloid cells at early extrahepatic carcinogenesis. The infiltrating immune cells via IL6–pSTAT3 immune–hepatocyte cross-talk cause the depletion of a master metabolic regulator, HNF4α, consequently leading to systemic metabolic changes that promote breast and pancreatic cancer proliferation and a worse outcome. Preserving HNF4α levels maintains liver metabolism and restricts carcinogenesis. Standard liver biochemical tests can identify early metabolic changes and predict patients’ outcomes and weight loss. Thus, the tumor induces early metabolic changes in its macroenvironment with diagnostic and potentially therapeutic implications for the host. Significance: Cancer growth requires a permanent nutrient supply starting from early disease stages. We find that the tumor extends its effect to the host's liver to obtain nutrients and rewires the systemic and tissue-specific metabolism early during carcinogenesis. Preserving liver metabolism restricts tumor growth and improves cancer outcomes. This article is highlighted in the In This Issue feature, p. 1501
Fine Tuning Venous Thromboembolism Risk Prediction in Patients With Cancer
Authors: Jean M. Connors
Journal: Journal of Clinical Oncology (2023)

The association between cancer and thrombosis is well known, with Trousseau first reporting on a syndrome of migratory thrombophlebitis associated with cancer more than 150 years ago.Despite dramatic advances in targeted cancer treatments in the past 20 years, the risk of venous thromboembolism (VTE) has not decreased.Recent population-based data have found that the incidence of VTE is now nine-fold higher than in the general population. 1 VTE is the second leading cause of death in patients with cancer, second only to cancer itself. 2 Randomized controlled trials (RCTs) of the use of prophylactic dose anticoagulants to prevent VTE in patients with cancer have shown significant reduction in the occurrence of VTE in treated patients compared with controls.Two of the largest studies included 4,362 patients and assessed the role of low molecular weight heparin (LMWH) for primary prophylaxis in patients with solid tumors receiving chemotherapy.Those assigned to LMWH for 6 months experienced a significant 50% or greater reduction in symptomatic thrombotic events compared with placebo. 3,4However, the absolute risk in the untreated ambulatory patients was small, at best 4%, making it difficult to recommend primary prophylaxis in all ambulatory patients with cancer given the large number of overtreated patients that would result.
Role of Race in the Interpretation of Pulmonary Function Tests: The American Thoracic Society’s Efforts to Mitigate Bias in Its Clinical Guidance
Authors: Kevin C. Wilson
Journal: American Journal of Respiratory and Critical Care Medicine (2023)

"Role of Race in the Interpretation of Pulmonary Function Tests: The American Thoracic Society's Efforts to Mitigate Bias in Its Clinical Guidance." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp. –
Assessment of Microglial Activation in Alzheimer Disease Using 18F-PBR06 PET
Authors: Kelsey Carter, Steven Cicero, Eero Rissanen, Shipra Dubey, Howard L. Weiner, Tarun Singhal
Journal: Clinical Nuclear Medicine (2023)

A 69-year-old woman with progressive short-term memory deficits was diagnosed with Alzheimer disease (MMSE 26/30, CDR 0.5) and underwent PET using 18 F-PBR06, a second-generation 18-kDa translocator protein ligand, targeting brain microglia and astrocytes. SUV and voxel-by-voxel binding potential maps (using simplified reference tissue method and a cerebellar pseudo-reference region) were generated. Images showed evidence of increased glial activation in biparietal cortices (including bilateral precuneus and posterior cingulate gyri) and bilateral frontal cortices. After 6 years of clinical follow-up, patient progressed to moderate cognitive impairment (CDR 2.0) and required assistance for activities of daily living.
Cancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer: a prospective cohort study
Authors: Bilal Asif, Amber Leila Sarvestani, Lauren A Gamble, Sarah G Samaranayake, Amber L Famiglietti, Grace-Ann Fasaye, Martha Quezado, Markku Miettinen, Louis Korman, Christopher Koh, Theo Heller, Jeremy L Davis
Journal: The Lancet Oncology (2023)
Toripalimab combined with definitive chemoradiotherapy in locally advanced oesophageal squamous cell carcinoma (EC-CRT-001): a single-arm, phase 2 trial
Authors: Yujia Zhu, Jing Wen, Qiaoqiao Li, Baoqing Chen, Lei Zhao, Shiliang Liu, Yadi Yang, Sifen Wang, Yingxin Lv, Jibin Li, Li Zhang, Yonghong Hu, Mengzhong Liu, Mian Xi
Journal: The Lancet Oncology (2023)
Multinational Association of Supportive Care in Cancer (MASCC) clinical practice guidelines for the prevention and management of acute radiation dermatitis: international Delphi consensus-based recommendations
Authors: Tara Behroozian, Pierluigi Bonomo, Partha Patel, Lauren Kanee, Samuel Finkelstein, Corina van den Hurk, Edward Chow, Julie Ryan Wolf, Tara Behroozian, Pierluigi Bonomo, Partha Patel, Lauren Kanee, Samuel Finkelstein, Corina van den Hurk, Edward Chow, Julie Ryan Wolf, Suvam Banerjee, Carlotta Becherini, Christine Boers-Doets, Marta Carlesimo, Gemma Caro, Maria Caterina Fortuna, Adrian Wai Chan, Lorraine Drapek, Azael Freites-Martinez, Satoshi Hirakawa, Emily Hoffman Smith, Nicola Alessandro Iacovelli, Bernice Kwong, Shing Fung Lee, Alina Markova, Robert Miller, Gustavo Nader Marta, Silvina Pugliese, Claire Marie Reyes Habito, Jolien Robijns, Viola Salvestrini, Leonard Christopher Schmeel, Mateusz Spalek, Mark Trombetta, Henry Chun Yip Wong
Journal: The Lancet Oncology (2023)
Testosterone suppression plus enzalutamide versus testosterone suppression plus standard antiandrogen therapy for metastatic hormone-sensitive prostate cancer (ENZAMET): an international, open-label, randomised, phase 3 trial
Authors: Christopher J Sweeney, Andrew J Martin, Martin R Stockler, Stephen Begbie, Leanna Cheung, Kim N Chi, Simon Chowdhury, Mark Frydenberg, Lisa G Horvath, Anthony M Joshua, Nicola J Lawrence, Gavin Marx, John McCaffrey, Ray McDermott, Margaret McJannett, Scott A North, Francis Parnis, Wendy Parulekar, David W Pook, Martin Neil Reaume, Shahneen K Sandhu, Alvin Tan, Thean Hsiang Tan, Alastair Thomson, Francisco Vera-Badillo, Scott G Williams, Diana Winter, Sonia Yip, Alison Y Zhang, Robert R Zielinski, Ian D Davis, Ehtesham Abdi, Suzanne Allan, Patricia Bastick, Stephen Begbie, Robert Blum, Karen Briscoe, Daniel Brungs, Sean Bydder, Bala Renuka Chittajallu, Michelle Cronk, Katharine Cuff, Ian D Davis, Anthony Dowling, Mark Frydenberg, Matthew George, Lisa Horvath, Elizabeth Hovey, Anthony Joshua, Narayan Karanth, Ganessan Kichenadasse, Laurence Krieger, Gavin Marx, Maitham Mathlum, Louise Nott, Zulfiquer Otty, Francis Parnis, David Pook, Shahneen Sandhu, Sanjeev Sewak, Amanda Stevanovic, Martin Stockler, Aneta Suder, Hsiang Tan, Javier Torres, Simon Troon, Craig Underhill, Andrew Weickhardt, Robert Zielinski, Tahir Abbas, Ghadeer Anan, Chris Booth, Holly Campbell, Kim Chi, Joseph Chin, Edmond Chouinard, Bryan Donnelly, Darrel Drachenberg, Amir Faghih, Antonio Finelli, Sebastien Hotte, Krista Noonan, Scott North, Mohammad Rassouli, Neil Reaume, Ricardo Rendon, Fred Saad, Evgeny Sadikov, Eric Vigneault, Pawel Zalewski, John McCaffrey, Ray McDermott, Patrick Morris, Miriam O'Connor, Paul Donnellan, Dearbhaile O'Donnell, Jim Edwards, Peter Fong, Alvin Tan, Simon Chowdhury, Simon Crabb, Omar Khan, Vincent Khoo, Graham Macdonald, Heather Payne, Angus Robinson, Jonathon Shamash, John Staffurth, Carys Thomas, Alastair Thomson, Christopher J Sweeney
Journal: The Lancet Oncology (2023)
Eprenetapopt combined with venetoclax and azacitidine in TP53-mutated acute myeloid leukaemia: a phase 1, dose-finding and expansion study
Authors: Guillermo Garcia-Manero, Aaron D Goldberg, Eric S Winer, Jessica K Altman, Amir T Fathi, Olatoyosi Odenike, Gail J Roboz, Kendra Sweet, Crystal Miller, Anders Wennborg, Denice K Hickman, Rashmi Kanagal-Shamanna, Hagop Kantarjian, Jeffrey Lancet, Rami Komrokji, Eyal C Attar, David A Sallman
Journal: The Lancet Haematology (2023)
Promoting cancer prevention through World Cancer Day in Nigeria
Authors: Runcie C W Chidebe, L Leigh Leibel, Tochukwu C Orjiakor, Ashish Shrestha, Agha A Agha, Duygu Altinok Dindar, Batuhan Kisakol, Sampson C Ipiankama, Ifeoma J Okoye, Malcolm Mason, Aviane Auguste, Darlingtina K Esiaka
Journal: The Lancet Oncology (2023)
Current drug development and trial designs in neuro-oncology: report from the first American Society of Clinical Oncology and Society for Neuro-Oncology Clinical Trials Conference
Authors: Rifaquat Rahman, Mei-Yin C Polley, Laura Alder, Priscilla K Brastianos, Carey K Anders, Hussein A Tawbi, Minesh Mehta, Patrick Y Wen, Susan Geyer, John de Groot, Gelareh Zadeh, Steven Piantadosi, Evanthia Galanis, Mustafa Khasraw
Journal: The Lancet Oncology (2023)
Global representation among journal editors in haematology: are we diverse, equitable, and inclusive?
Authors: Andrés Noyola-Pérez, Lourdes Gil-Flores, Héctor A Martínez-Espinosa, Emilia Ramos-Barrera, Víctor Rodríguez-González, Lillian Sung, Mónica Guzman, Nada Hamad, Perla R Colunga-Pedraza, Luz Tarín-Arzaga, Olga G Cantú-Rodríguez, Homero Gutiérrez-Aguirre, José Carlos Jaime-Pérez, David Gómez-Almaguer, Andrés Gómez-De León
Journal: The Lancet Haematology (2023)
Advanced surface engineering of titanium materials for biomedical applications: From static modification to dynamic responsive regulation
Authors: Pinliang Jiang, Yanmei Zhang, Ren Hu, Bin Shi, Lihai Zhang, Qiaoling Huang, Yun Yang, Peifu Tang, Changjian Lin
Journal: Bioactive Materials (2023)

Titanium (Ti) and its alloys have been widely used as orthopedic implants, because of their favorable mechanical properties, corrosion resistance and biocompatibility. Despite their significant success in various clinical applications, the probability of failure, degradation and revision is undesirably high, especially for the patients with low bone density, insufficient quantity of bone or osteoporosis, which renders the studies on surface modification of Ti still active to further improve clinical results. It is discerned that surface physicochemical properties directly influence and even control the dynamic interaction that subsequently determines the success or rejection of orthopedic implants. Therefore, it is crucial to endow bulk materials with specific surface properties of high bioactivity that can be performed by surface modification to realize the osseointegration. This article first reviews surface characteristics of Ti materials and various conventional surface modification techniques involving mechanical, physical and chemical treatments based on the formation mechanism of the modified coatings. Such conventional methods are able to improve bioactivity of Ti implants, but the surfaces with static state cannot respond to the dynamic biological cascades from the living cells and tissues. Hence, beyond traditional static design, dynamic responsive avenues are then emerging. The dynamic stimuli sources for surface functionalization can originate from environmental triggers or physiological triggers. In short, this review surveys recent developments in the surface engineering of Ti materials, with a specific emphasis on advances in static to dynamic functionality, which provides perspectives for improving bioactivity and biocompatibility of Ti implants.
A self-monitoring microneedle patch for light-controlled synergistic treatment of melanoma
Authors: Chenyuan Wang, Yongnian Zeng, Kai-Feng Chen, Jiawei Lin, Qianqian Yuan, Xue Jiang, Gaosong Wu, Fubing Wang, Yong-Guang Jia, Wei Li
Journal: Bioactive Materials (2023)

Melanoma is the most aggressive and malignant form of skin cancer. Current melanoma treatment methods generally suffer from frequent drug administration as well as difficulty in direct monitoring of drug release. Here, a self-monitoring microneedle (MN)-based drug delivery system, which integrates a dissolving MN patch with aggregation-induced emission (AIE)-active PATC microparticles, is designed to achieve light-controlled pulsatile chemo-photothermal synergistic therapy of melanoma. The PATC polymeric particles, termed D/I@PATC, encapsulate both of chemotherapeutic drug doxorubicin (DOX) and the photothermal agent indocyanine green (ICG). Upon light illumination, PATC gradually dissociates into smaller particles, causing the release of encapsulated DOX and subsequent fluorescence intensity change of PATC particles, thereby not only enabling direct observation of the drug release process under light stimuli, but also facilitating verification of drug release by fluorescence recovery after light trigger. Moreover, encapsulation of ICG in PATC particles displays significant improvement of its photothermal stability both in vitro and in vivo. In a tumor-bearing mouse, the application of one D/I@PATC MN patch combining with two cycles of light irradiation showed excellent controllable chemo-photothermal efficacy and exhibited ∼97% melanoma inhibition rate without inducing any evident systemic toxicity, suggesting a great potential for skin cancer treatment in clinics.
Endemic or regionally limited bacterial and viral infections in haematopoietic stem-cell transplantation recipients: a Worldwide Network for Blood and Marrow Transplantation (WBMT) Review
Authors: Ibrahim N Muhsen, Sebastian Galeano, Dietger Niederwieser, Mickey B C Koh, Per Ljungman, Clarisse M Machado, Mohamed A Kharfan-Dabaja, Rafael de la Camara, Yoshihisa Kodera, Jeff Szer, Walid Rasheed, Simone Cesaro, Shahrukh K Hashmi, Adriana Seber, Yoshiko Atsuta, Mostafa F Mohammed Saleh, Alok Srivastava, Jan Styczynski, Abdulrahman Alrajhi, Reem Almaghrabi, Muhammad Bilal Abid, Roy F Chemaly, Usama Gergis, Eolia Brissot, Riad El Fakih, Marcie Riches, Malgorzata Mikulska, Nina Worel, Daniel Weisdorf, Hildegard Greinix, Catherine Cordonnier, Mahmoud Aljurf
Journal: The Lancet Haematology (2023)
Endemic or regionally limited parasitic and fungal infections in haematopoietic stem-cell transplantation recipients: a Worldwide Network for Blood and Marrow Transplantation (WBMT) Review
Authors: Ibrahim N Muhsen, Sebastian Galeano, Dietger Niederwieser, Mickey B C Koh, Per Ljungman, Clarisse M Machado, Mohamed A Kharfan-Dabaja, Rafael de la Camara, Yoshihisa Kodera, Jeff Szer, Walid Rasheed, Simone Cesaro, Shahrukh K Hashmi, Adriana Seber, Yoshiko Atsuta, Mostafa F Mohammed Saleh, Alok Srivastava, Jan Styczynski, Abdulrahman Alrajhi, Reem Almaghrabi, Muhammad Bilal Abid, Roy F Chemaly, Usama Gergis, Eolia Brissot, Riad El Fakih, Marcie Riches, Malgorzata Mikulska, Nina Worel, Daniel Weisdorf, Hildegard Greinix, Catherine Cordonnier, Mahmoud Aljurf
Journal: The Lancet Haematology (2023)
Blood Levels of Angiotensinogen and Hypertension in the Multi-Ethnic Study of Atherosclerosis (MESA)
Authors: Patrick J. Trainor, Michela Brambatti, Samantha M. Carlisle, Adam E. Mullick, Sanjiv J. Shah, Tanvir Kahlon, Diana Otero Mostacero, Hossein Mousavi, Erin S. Morgan, Yvonne Tami, Erin D. Michos, Pamela Ouyang, Sotirios Tsimikas, Andrew P. DeFilippis
Journal: Journal of the American College of Cardiology (2023)
Early Lead Extraction for Infected Implanted Cardiac Electronic Devices
Authors: Dhanunjaya R. Lakkireddy, Douglas S. Segar, Ami Sood, MaryAnn Wu, Archana Rao, M. Rizwan Sohail, Sean D. Pokorney, Carina Blomström-Lundqvist, Jonathan P. Piccini, Christopher B. Granger
Journal: Journal of the American College of Cardiology (2023)

Infection remains a serious complication associated with the cardiac implantable electronic devices (CIEDs), leading to substantial clinical and economic burden globally. This review assesses the burden of cardiac implantable electronic device infection (CIED-I), evidence for treatment recommendations, barriers to early diagnosis and appropriate therapy, and potential solutions. Multiple clinical practice guidelines recommended complete system and lead removal for CIED-I when appropriate. CIED extraction for infection has been consistently reported with high success, low complication, and very low mortality rates. Complete and early extraction was associated with significantly better clinical and economic outcome compared with no or late extraction. However, significant gaps in knowledge and poor recommendation compliance have been reported. Barriers to optimal management may include diagnostic delay, knowledge gaps, and limited access to expertise. A multipronged approach, including education of all stakeholders, a CIED-I alert system, and improving access to experts, could help bring paradigm shift in the treatment of this serious condition.
Lung Cancer in Armenia
Authors: Davit Zohrabyan, Nune Karapetyan, Samvel Danielyan, Tatul Saghatelyan, Liana Safaryan, Samvel Bardakhchyan, Gevorg Tamamyan, Martin Harutyunyan, Marine Rushanyan, Gohar Mkrtchyan, Sergey Badalyan, Armen Avagyan, Lilit Harutyunyan, Armine Lazaryan, Sergey Mkhitaryan, Armen Khanoyan, Amalya Sargsyan, Mariam Mailyan, David Mamunts, Anzhela Asadyan, Parandzem Khachatryan, Armen Mkhitaryan, Gregory P. Kalemkerian
Journal: Journal of Thoracic Oncology (2023)
Hematopoietic Somatic Mosaicism Is Associated With an Increased Risk of Postoperative Atrial Fibrillation
Authors: Sandro Ninni, David Dombrowicz, Tanya Kuznetsova, Rocio Vicario, Vance Gao, Olivier Molendi-Coste, Joel Haas, Eloise Woitrain, Augustin Coisne, Annette E. Neele, Koen Prange, Lisa Willemsen, Samy Aghezzaf, Stamatina Fragkogianni, Amine Tazibet, Laurent Pineau, James Robert White, Jérôme Eeckhoute, Mohamed Koussa, Henri Dubrulle, Francis Juthier, Jérôme Soquet, André Vincentelli, Jean-Louis Edme, Menno de Winther, Frederic Geissmann, Bart Staels, David Montaigne
Journal: Journal of the American College of Cardiology (2023)
Impact of Moderate Aortic Stenosis in Patients With Heart Failure With Reduced Ejection Fraction
Authors: Kathleen R. Khan, Omar A. Khan, Chen Chen, Yuxi Liu, Ritvik R. Kandanelly, Paris J. Jamiel, Varsha Tanguturi, Judy Hung, Ignacio Inglessis, Jonathan J. Passeri, Nathaniel B. Langer, Sammy Elmariah
Journal: Journal of the American College of Cardiology (2023)