tbuckley/cabot-search huggingface dataset:
Acute evaluation of sport-related concussion and implications for the Sport Concussion Assessment Tool (SCAT6) for adults, adolescents and children: a systematic review
Authors: Ruben J Echemendia, Joel S Burma, Jared M Bruce, Gavin A Davis, Christopher C Giza, Kevin M Guskiewicz, Dhiren Naidu, Amanda Marie Black, Steven Broglio, Simon Kemp, Jon S Patricios, Margot Putukian, Roger Zemek, Juan Carlos Arango-Lasprilla, Christopher M Bailey, Benjamin L Brett, Nyaz Didehbani, Gerry Gioia, Stanley A Herring, David Howell, Christina L Master, Tamara C Valovich McLeod, William P Meehan, Zahra Premji, Danielle Salmon, Jacqueline van Ierssel, Neil Bhathela, Michael Makdissi, Samuel R Walton, James Kissick, Jamie Pardini, Kathryn J Schneider
Journal: British Journal of Sports Medicine (2023)

Objectives To systematically review the scientific literature regarding the acute assessment of sport-related concussion (SRC) and provide recommendations for improving the Sport Concussion Assessment Tool (SCAT6). Data sources Systematic searches of seven databases from 2001 to 2022 using key words and controlled vocabulary relevant to concussion, sports, SCAT, and acute evaluation. Eligibility criteria (1) Original research articles, cohort studies, case–control studies, and case series with a sample of &gt;10; (2) ≥80% SRC; and (3) studies using a screening tool/technology to assess SRC acutely (&lt;7 days), and/or studies containing psychometric/normative data for common tools used to assess SRC. Data extraction Separate reviews were conducted involving six subdomains: Cognition, Balance/Postural Stability, Oculomotor/Cervical/Vestibular, Emerging Technologies, and Neurological Examination/Autonomic Dysfunction. Paediatric/Child studies were included in each subdomain. Risk of Bias and study quality were rated by coauthors using a modified SIGN (Scottish Intercollegiate Guidelines Network) tool. Results Out of 12 192 articles screened, 612 were included (189 normative data and 423 SRC assessment studies). Of these, 183 focused on cognition, 126 balance/postural stability, 76 oculomotor/cervical/vestibular, 142 emerging technologies, 13 neurological examination/autonomic dysfunction, and 23 paediatric/child SCAT. The SCAT discriminates between concussed and non-concussed athletes within 72 hours of injury with diminishing utility up to 7 days post injury. Ceiling effects were apparent on the 5-word list learning and concentration subtests. More challenging tests, including the 10-word list, were recommended. Test–retest data revealed limitations in temporal stability. Studies primarily originated in North America with scant data on children. Conclusion Support exists for using the SCAT within the acute phase of injury. Maximal utility occurs within the first 72 hours and then diminishes up to 7 days after injury. The SCAT has limited utility as a return to play tool beyond 7 days. Empirical data are limited in pre-adolescents, women, sport type, geographical and culturally diverse populations and para athletes. PROSPERO registration number CRD42020154787.
Introducing the Child Sport Concussion Office Assessment Tool 6 (Child SCOAT6)
Authors: Gavin A Davis, Jon S Patricios, Laura K Purcell, Vicki Anderson, Gerard A Gioia, Christopher C Giza, Keith Owen Yeates, Osman Hassan Ahmed, Cheri Blauwet, Daniel Corwin, Christina L Master, Geoff M Schneider, Jacqueline van Ierssel, Ruben J Echemendia, Pierre Fremont, Gordon Ward Fuller, Stanley Herring, Kimberly G Harmon, Kirsten Holte, Mike Loosemore, Michael Makdissi, Michael McCrea, William P Meehan, Patrick O'Halloran, Zahra Premji, Margot Putukian, Isla Jordan Shill, Michael Turner, Kenzie Vaandering, Nick Webborn, Kathryn J Schneider
Journal: British Journal of Sports Medicine (2023)
When should an athlete retire or discontinue participating in contact or collision sports following sport-related concussion? A systematic review
Authors: Michael Makdissi, Meghan L Critchley, Robert C Cantu, Jeffrey G Caron, Gavin A Davis, Ruben J Echemendia, Pierre Fremont, K Alix Hayden, Stanley A Herring, Sidney R Hinds, Barry Jordan, Simon Kemp, Michael McNamee, David Maddocks, Shinji Nagahiro, Jon Patricios, Margot Putukian, Michael Turner, Stacy Sick, Kathryn J Schneider
Journal: British Journal of Sports Medicine (2023)

Objective To systematically review the scientific literature regarding factors to consider when providing advice or guidance to athletes about retirement from contact or collision sport following sport-related concussion (SRC), and to define contraindications to children/adolescent athletes entering or continuing with contact or collision sports after SRC. Data sources Medline, Embase, SPORTSDiscus, APA PsycINFO, CINAHL and Cochrane Central Register of Controlled Trials were searched systematically. Study eligibility criteria Studies were included if they were (1) original research, (2) reported on SRC as the primary source of injury, (3) evaluated the history, clinical assessment and/or investigation of findings that may preclude participation in sport and (4) evaluated mood disturbance and/or neurocognitive deficits, evidence of structural brain injury or risk factors for increased risk of subsequent SRC or prolonged recovery. Results Of 4355 articles identified, 93 met the inclusion criteria. None of the included articles directly examined retirement and/or discontinuation from contact or collision sport. Included studies examined factors associated with increased risk of recurrent SRC or prolonged recovery following SRC. In general, these were low-quality cohort studies with heterogeneous results and moderate risk of bias. Higher number and/or severity of symptoms at presentation, sleep disturbance and symptom reproduction with Vestibular Ocular Motor Screen testing were associated with prolonged recovery and history of previous concussion was associated with a risk of further SRC. Conclusion No evidence was identified to support the inclusion of any patient-specific, injury-specific or other factors (eg, imaging findings) as absolute indications for retirement or discontinued participation in contact or collision sport following SRC. PROSPERO registration number CRD42022155121.
Child SCOAT6
Authors: Gavin A Davis, Jon S Patricios, Laura K Purcell, Vicki Anderson, Gerry Gioia, Christopher C Giza, Keith Owen Yeates, Osman Hassan Ahmed, Cheri Blauwet, Daniel Corwin, Christina L Master, Geoff Schneider, Jacqueline van Ierssel, Ruben J Echemendia, Pierre Fremont, Gordon Ward Fuller, Kimberly G Harmon, Stanley A Herring, Kirsten Holte, Mike Loosemore, Michael Makdissi, Michael McCrea, William P Meehan, Patrick O'Halloran, Zahra Premji, Margot Putukian, Isla Jordan Shill, Michael Turner, Kenzie Vaandering, Nick Webborn, Kathryn J Schneider
Journal: British Journal of Sports Medicine (2023)

![Graphic][1]</img> ![Graphic][2]</img> ![Graphic][3]</img> ![Graphic][4]</img> ![Graphic][5]</img> ![Graphic][6]</img> ![Graphic][7]</img> ![Graphic][8]</img> ![Graphic][9]</img> ![Graphic][10]</img> ![Graphic][11]</img> ![Graphic][12]</img> ![Graphic][13]</img> ![Graphic][14]</img> ![Graphic][15]</img> ### Supplementary data [bjsports-2023-106984supp001.pdf] ### Supplementary data [bjsports-2023-106984supp002.pdf] ### Patient consent for publication Not applicable. ### Ethics approval Not applicable. [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif [5]: /embed/inline-graphic-5.gif [6]: /embed/inline-graphic-6.gif [7]: /embed/inline-graphic-7.gif [8]: /embed/inline-graphic-8.gif [9]: /embed/inline-graphic-9.gif [10]: /embed/inline-graphic-10.gif [11]: /embed/inline-graphic-11.gif [12]: /embed/inline-graphic-12.gif [13]: /embed/inline-graphic-13.gif [14]: /embed/inline-graphic-14.gif [15]: /embed/inline-graphic-15.gif
Role of biomarkers and emerging technologies in defining and assessing neurobiological recovery after sport-related concussion: a systematic review
Authors: Jason B Tabor, Benjamin L Brett, Lindsay Nelson, Timothy Meier, Linden C Penner, Andrew R. Mayer, Ruben J Echemendia, Thomas McAllister, William P Meehan, Jon Patricios, Michael Makdissi, Silvia Bressan, Gavin A Davis, Zahra Premji, Kathryn J Schneider, Henrik Zetterberg, Michael McCrea
Journal: British Journal of Sports Medicine (2023)

Objective Determine the role of fluid-based biomarkers, advanced neuroimaging, genetic testing and emerging technologies in defining and assessing neurobiological recovery after sport-related concussion (SRC). Design Systematic review. Data sources Searches of seven databases from 1 January 2001 through 24 March 2022 using keywords and index terms relevant to concussion, sports and neurobiological recovery. Separate reviews were conducted for studies involving neuroimaging, fluid biomarkers, genetic testing and emerging technologies. A standardised method and data extraction tool was used to document the study design, population, methodology and results. Reviewers also rated the risk of bias and quality of each study. Eligibility criteria for selecting studies Studies were included if they: (1) were published in English; (2) represented original research; (3) involved human research; (4) pertained only to SRC; (5) included data involving neuroimaging (including electrophysiological testing), fluid biomarkers or genetic testing or other advanced technologies used to assess neurobiological recovery after SRC; (6) had a minimum of one data collection point within 6 months post-SRC; and (7) contained a minimum sample size of 10 participants. Results A total of 205 studies met inclusion criteria, including 81 neuroimaging, 50 fluid biomarkers, 5 genetic testing, 73 advanced technologies studies (4 studies overlapped two separate domains). Numerous studies have demonstrated the ability of neuroimaging and fluid-based biomarkers to detect the acute effects of concussion and to track neurobiological recovery after injury. Recent studies have also reported on the diagnostic and prognostic performance of emerging technologies in the assessment of SRC. In sum, the available evidence reinforces the theory that physiological recovery may persist beyond clinical recovery after SRC. The potential role of genetic testing remains unclear based on limited research. Conclusions Advanced neuroimaging, fluid-based biomarkers, genetic testing and emerging technologies are valuable research tools for the study of SRC, but there is not sufficient evidence to recommend their use in clinical practice. PROSPERO registration number CRD42020164558.
Introducing the Concussion Recognition Tool 6 (CRT6)
Authors: Ruben J Echemendia, Osman Hassan Ahmed, Christopher M Bailey, Jared M Bruce, Joel S Burma, Gavin A Davis, Gerry Gioia, David Howell, Gordon Ward Fuller, Christina L Master, Jacqueline van Ierssel, Jamie Pardini, Kathryn J Schneider, Samuel R Walton, Roger Zemek, Jon Patricios
Journal: British Journal of Sports Medicine (2023)
Introducing the Child Sport Concussion Assessment Tool 6 (Child SCAT6)
Authors: Gavin A Davis, Ruben J Echemendia, Osman Hassan Ahmed, Vicki Anderson, C Blauwet, Benjamin L Brett, Steven Broglio, Jared M Bruce, Joel S Burma, Gerard A Gioia, Christopher C Giza, Kevin M Guskiewicz, Kimberly G Harmon, Stanley Herring, Michael Makdissi, Christina L Master, Michael McCrea, Tamara C Valovich McLeod, William P Meehan,, Dhiren Naidu, Jon Patricios, Laura K Purcell, Margot Putukian, Kathryn J Schneider, Samuel R Walton, Keith Owen Yeates, Roger Zemek
Journal: British Journal of Sports Medicine (2023)

RATIONALEThe requirement for a child-specific tool that can be used by health care professionals (HCPs) in the management of sport-related concussion (SRC) was recognised by the Concussion in Sport Group (CISG) in 2012 with the introduction of the Child Sport Concussion Assessment Tool 3 (Child SCAT3) for use with children ages 5-12 years. 1 This tool paralleled and complemented the SCAT3, which was developed for use in athletes, ages 13 years and over. 1 The CISG revised the Child SCAT3 following the fifth International Consensus Conference on Concussion in Sport (Berlin 2016), with the release of the Child SCAT5. 2 At that time, the version number (5) was chosen to align the version number with the consensus meeting number, and therefore, there is no Child SCAT4.During 6th International Conference on Concussion in Sport held in Amsterdam in 2022, the CISG reviewed the evidence to implement improvements to the Child SCAT5 and develop the Child SCAT6.
Sport Concussion Office Assessment Tool 6 (SCOAT6)
Authors: Jon Patricios, Geoff M Schneider, Jacqueline van Ierssel, Laura K Purcell, Gavin A Davis, Ruben J Echemendia, Pierre Frémont, Gordon Ward Fuller, Stanley Herring, Kimberly G Harmon, Kirsten Holte, Mike Loosemore, Michael Makdissi, Michael McCrea, William P Meehan, Patrick O'Halloran, Zahra Premji, Margot Putukian, Isla Jordan Shill, Michael Turner, Kenzie Vaandering, Nick Webborn, Keith Owen Yeates, Kathryn J Schneider
Journal: British Journal of Sports Medicine (2023)

![Graphic][1]</img> ![Graphic][2]</img> ![Graphic][3]</img> ![Graphic][4]</img> ![Graphic][5]</img> ![Graphic][6]</img> ![Graphic][7]</img> ![Graphic][8]</img> ![Graphic][9]</img> ![Graphic][10]</img> ![Graphic][11]</img> ![Graphic][12]</img> ![Graphic][13]</img> ![Graphic][14]</img> ![Graphic][15]</img> ### Supplementary data [bjsports-2023-106859supp001.pdf] ### Patient consent for publication Not applicable. ### Ethics approval Not applicable. [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif [5]: /embed/inline-graphic-5.gif [6]: /embed/inline-graphic-6.gif [7]: /embed/inline-graphic-7.gif [8]: /embed/inline-graphic-8.gif [9]: /embed/inline-graphic-9.gif [10]: /embed/inline-graphic-10.gif [11]: /embed/inline-graphic-11.gif [12]: /embed/inline-graphic-12.gif [13]: /embed/inline-graphic-13.gif [14]: /embed/inline-graphic-14.gif [15]: /embed/inline-graphic-15.gif
Introducing the Sport Concussion Assessment Tool 6 (SCAT6)
Authors: Ruben J Echemendia, Benjamin L Brett, Steven Broglio, Gavin A Davis, Christopher C Giza, Kevin M Guskiewicz, Kimberly G Harmon, Stanley Herring, David R Howell, Christina L Master, Tamara C Valovich McLeod, Michael McCrea, Dhiren Naidu, Jon Patricios, Margot Putukian, Samuel R Walton, Kathryn J Schneider, Joel S Burma, Jared M Bruce
Journal: British Journal of Sports Medicine (2023)
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Authors: Thomas O'keefe, Anne Wallace, Thomas O', Rita Mukhtar, Christina Yau, Laura Esserman
Journal: JAMA Surgery (2023)

Although treating pCR as a binary variable defined only by residual invasive disease is appealing from the standpoint of simplicity for planning analyses for future studies and for the purposes of clinical management, we feel that the reported findings do not support this.The results suggest that pCR with residual in situ disease may have prognostic utility and that this outcome should be included as an independent end point for efficacy of neoadjuvant regimens, representing an inferior response to pCR with the absence of DCIS but a superior response compared with the absence of pCR.The authors note that pCR is considered an end point for accelerated drug approval in neoadjuvant trials.The maintenance of a status of pCR with DCIS would allow for further stratification of the associations of novel agents with outcomes and possibly allow for the establishment of differential effects by breast cancer subtype.
Intralesional Certolizumab for Refractory Lupus Pernio
Authors: Charles Dunn, Zackary Whitney, Michael Foss, Austin Ambur, Stephen Eubanks, Adam Leavitt, Rajiv Nathoo
Journal: JAMA Dermatology (2023)

This case report describes a patient with refractory lupus pernio that responded to treatment with a series of intralesional certolizumab injections.
Hospital Walking Program Reduced Nursing Facility Admission
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mitigating Cardiovascular Disease Risk in Patients With Type 2 Diabetes and Chronic Kidney Disease—An Unmet Need With Promising Solutions
Authors: Janani Rangaswami, Roy O. Mathew
Journal: JAMA Cardiology (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Spatial transcriptomics combined with single‐cell <scp>RNA</scp>‐sequencing unravels the complex inflammatory cell network in atopic dermatitis
Authors: Yasutaka Mitamura, Matthias Reiger, Juno Kim, Yi Xiao, Damir Zhakparov, Ge Tan, Beate Rückert, Arturo O. Rinaldi, Katja Baerenfaller, Mübeccel Akdis, Marie‐Charlotte Brüggen, Kari C. Nadeau, Patrick M. Brunner, Damian Roqueiro, Claudia Traidl‐Hoffmann, Cezmi A. Akdis
Journal: Allergy (2023)

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease with complex pathogenesis for which the cellular and molecular crosstalk in AD skin has not been fully understood.Skin tissues examined for spatial gene expression were derived from the upper arm of 6 healthy control (HC) donors and 7 AD patients (lesion and nonlesion). We performed spatial transcriptomics sequencing to characterize the cellular infiltrate in lesional skin. For single-cell analysis, we analyzed the single-cell data from suction blister material from AD lesions and HC skin at the antecubital fossa skin (4 ADs and 5 HCs) and full-thickness skin biopsies (4 ADs and 2 HCs). The multiple proximity extension assays were performed in the serum samples from 36 AD patients and 28 HCs.The single-cell analysis identified unique clusters of fibroblasts, dendritic cells, and macrophages in the lesional AD skin. Spatial transcriptomics analysis showed the upregulation of COL6A5, COL4A1, TNC, and CCL19 in COL18A1-expressing fibroblasts in the leukocyte-infiltrated areas in AD skin. CCR7-expressing dendritic cells (DCs) showed a similar distribution in the lesions. Additionally, M2 macrophages expressed CCL13 and CCL18 in this area. Ligand-receptor interaction analysis of the spatial transcriptome identified neighboring infiltration and interaction between activated COL18A1-expressing fibroblasts, CCL13- and CCL18-expressing M2 macrophages, CCR7- and LAMP3-expressing DCs, and T cells. As observed in skin lesions, serum levels of TNC and CCL18 were significantly elevated in AD, and correlated with clinical disease severity.In this study, we show the unknown cellular crosstalk in leukocyte-infiltrated area in lesional skin. Our findings provide a comprehensive in-depth knowledge of the nature of AD skin lesions to guide the development of better treatments.
Customizing 3D Structures of Vertically Aligned Carbon Nanotubes to Direct Neural Stem Cell Differentiation
Authors: Luís Nascimento, Cristiana Fernandes, Ricardo. M. Silva, Ângela Semitela, Bárbara M. de Sousa, Paula A. A. P. Marques, Sandra I. Vieira, Rui. F. Silva, Nathalie Barroca, Gil Gonçalves
Journal: Advanced Healthcare Materials (2023)

Neural tissue-related illnesses have a high incidence and prevalence in society. Despite intensive research efforts to enhance the regeneration of neural cells into functional tissue, effective treatments are still unavailable. Here, a novel therapeutic approach based on vertically aligned carbon nanotube forests (VA-CNT forests) and periodic VA-CNT micropillars produced by thermal chemical vapor deposition is explored. In addition, honeycomb-like and flower-like morphologies are created. Initial viability testing reveals that NE-4C neural stem cells seeded on all morphologies survive and proliferate. In addition, free-standing VA-CNT forests and capillary-driven VA-CNT forests are created, with the latter demonstrating enhanced capacity to stimulate neuritogenesis and network formation under minimal differentiation medium conditions. This is attributed to the interaction between surface roughness and 3D-like morphology that mimics the native extracellular matrix, thus enhancing cellular attachment and communication. These findings provide a new avenue for the construction of electroresponsive scaffolds based on CNTs for neural tissue engineering.
Hybrid COVID-19 Immunity Common by Fall of 2022
Authors: Emily Harris
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physician and Biomedical Scientist Harassment on Social Media During the COVID-19 Pandemic
Authors: Regina Royan, Tricia Rae Pendergrast, Nicole C. Woitowich, N. Seth Trueger, Lawren Wooten, Shikha Jain, Vineet M. Arora
Journal: JAMA Network Open (2023)

This survey study assesses the frequency and nature of harassment on social media experienced by physicians, biomedical scientists, and trainees during the COVID-19 pandemic.