tbuckley/cabot-search huggingface dataset:
Syntaxin17 contributes to obesity cardiomyopathy through promoting mitochondrial Ca2+ overload in a Parkin-MCUb-dependent manner
Authors: Haixia Xu, Wenjun Yu, Mingming Sun, Yaguang Bi, Ne N Wu, Yuan Zhou, Qi Yang, Mengjiao Zhang, Junbo Ge, Yingmei Zhang, Jun Ren
Journal: Metabolism (2023)
Imported rickettsial infections to the United Kingdom, 2015–2020
Authors: Clare E. Warrell, Jane Osborne, Laura Nabarro, Barry Gibney, Daniel P. Carter, Jennifer Warner, Catherine F. Houlihan, Timothy J.G. Brooks, Tommy Rampling
Journal: Journal of Infection (2023)

The burden of imported rickettsial infection in the UK is not previously described. This retrospective review identifies rickettsial cases diagnosed at the national reference laboratory between 2015 and 2022.Samples testing positive for spotted fever group, typhus group, and scrub typhus IgG/IgM on acute and convalescent blood samples, and/or PCR on tissue/blood were categorized as suspected, confirmed or past infection.220 patients had rickettsioses, and the commonest import was acute spotted fever group infection (61%, 125/205), 54% (62/114) from South Africa. In acute typhus group cases, 60% (40/67) were from Southeast Asia. One patient with Rickettsia typhi bacteremia died. Scrub typhus group infections (5%, 10/205) were exclusively from Asia and the Western Pacific regions. Overall, 43% of confirmed cases (39/91) had not received doxycycline prior to results.Rickettsial infections are important and under-recognized causes of imported fever in the UK. Thorough history, examination, and timely treatment with doxycycline should be considered if there is suspicion of Rickettsia infection before testing.
Diagnosis of COVID-19 by sound-based analysis of vocal recordings
Authors: P. Carreiro-Martins, P. Paixão, I. Caires, A. Rodrigues, P. Matias, H. Gamboa, A. Carreiro, F. Soares, P. Gomez, J. Sousa, N. Neuparth
Journal: Pulmonology (2023)

The COVID-19 pandemic has had a significant impact on the world, with widespread illness, death, and economic disruption.The pandemic constantly evolves as new virus variants emerge, and governments respond with new measures.The development of a diverse range of diagnostic tests 1 has been triggered to deal with the situation, which can be summarised in three major categories: molecular tests, rapid antigen tests and serology.Molecular tests have been the reference (real-time polymerase chain reaction -RT-PCR), but common to all, these are invasive, although minimally, and costly diagnostic techniques.Although at-home rapid antigen tests are currently available, they are invasive and uncomfortable, vary in accuracy depending on how they are done and must be quickly accessible. 1 These characteristics may raise perceived barriers to COVID-19 testing and limit the detection of the disease.Vaccines have been unevenly
Repair what is lost: Neuroprotection through neural stem cells in progressive MS
Authors: Menno M. Schoonheim, Eva M.M. Strijbis
Journal: Cell Reports Medicine (2023)

Genchi et al.1 report the first phase 1 trial of neural stem cell transplantation in multiple sclerosis showing a reduction in gray matter atrophy. Results give hope for a new era of induced neuroprotection, especially in progressive multiple sclerosis.
Lecanemab reduces brain amyloid-β and delays cognitive worsening
Authors: David S. Knopman
Journal: Cell Reports Medicine (2023)

Lecanemab cleared amyloid-β in two-thirds and reduced the rate of cognitive and functional worsening in people with mild cognitive impairment and mild dementia due to Alzheimer disease in an 18-month double-blinded randomized placebo-controlled trial reported by van Dyck et al.
Abstract 3175: Injection of GSK-3{beta} Overexpressing Mesenchymal Stem Cells Attenuates Cardiac Dysfunction After Myocardial Infarction Through Cardiomyocyte Differentiation and Secretion of Angiogenic Factors
Authors: Jaeyeaon Cho, Peiyong Zhai, Junichi Sadoshima
Journal: Circulation (2009)
Abstract 2656: Effect of Assisted Circulation in Prolonged Cardiopulmonary Resuscitation
Authors: Yih-Sharng Chen, Hsi-Yu Yu, Wen-Je Ko, Jou-Wei Lin, Shu-Chien Huang, Nai-Hsin Chi, I-Hui Wu, Nai-Kuan Chou, Shoei-Shen Wang, Fang-Yue Lin
Journal: Circulation (2006)

Introduction - Application of extracorporeal life support (ECLS) in patients undergoing cardiopulmonary resuscitation (CPR) had been advocated with acceptable survival but no enough evidence of com...
Aplastic Anemia
Authors: B M Camitta, R Storb, E D Thomas
Journal: New England Journal of Medicine (1982)

A PLASTIC anemia was first described by Ehrlich in 1888. It is not a single disease but, rather, a group of disorders characterized by peripheral-blood pancytopenia, variable bone-marrow hypocellularity, and the absence of underlying malignant or myeloproliferative disease. "Aplastic pancytopenia" would be a more accurate name, but Chauffard's original term has persisted. This review summarizes current concepts of the pathogenesis, diagnosis, treatment, and prognosis of marrow aplasias. The interested reader is referred to several excellent monographs for further data and references.1 2 3 4 5 Normal HematopoiesisNormal hematopoiesis occurs within a specialized physical and functional microenvironment.6 Thus, although fetal hematopoiesis originates in the . . .
Functional Evolution of Clustered Aquaporin Genes Reveals Insights into the Oceanic Success of Teleost Eggs
Authors: Alba Ferré, François Chauvigné, Anna Vlasova, Birgitta Norberg, Luca Bargelloni, Roderic Guigó, Roderick Nigel Finn, Joan Cerdà
Journal: Molecular Biology and Evolution (2023)

Abstract Aquaporin-mediated oocyte hydration is considered important for the evolution of pelagic eggs and the radiative success of marine teleosts. However, the molecular regulatory mechanisms controlling this vital process are not fully understood. Here, we analyzed &amp;gt;400 piscine genomes to uncover a previously unknown teleost-specific aquaporin-1 cluster (TSA1C) comprised of tandemly arranged aqp1aa-aqp1ab2-aqp1ab1 genes. Functional evolutionary analysis of the TSA1C reveals a ∼300-million-year history of downstream aqp1ab-type gene loss, neofunctionalization, and subfunctionalization, but with marine species that spawn highly hydrated pelagic eggs almost exclusively retaining at least one of the downstream paralogs. Unexpectedly, one-third of the modern marine euacanthomorph teleosts selectively retain both aqp1ab-type channels and co-evolved protein kinase-mediated phosphorylation sites in the intracellular subdomains together with teleost-specific Ywhaz-like (14-3-3ζ-like) binding proteins for co-operative membrane trafficking regulation. To understand the selective evolutionary advantages of these mechanisms, we show that a two-step regulated channel shunt avoids competitive occupancy of the same plasma membrane space in the oocyte and accelerates hydration. These data suggest that the evolution of the adaptive molecular regulatory features of the TSA1C facilitated the rise of pelagic eggs and their subsequent geodispersal in the oceanic currents.
Risk prediction of hepatitis B or C or HIV among newly diagnosed cancer patients
Authors: Joseph M Unger, Cathee Till, Jessica P Hwang, Kathryn B Arnold, Michael Leblanc, Dawn L Hershman, Scott D Ramsey
Journal: JNCI Journal of the National Cancer Institute (2023)

Abstract Background Screening for viral infection in cancer patients is inconsistent. A mechanism to readily identify cancer patients at increased risk of existing or prior viral infection could enhance screening efforts while reducing costs. Methods We identified factors associated with increased risk of past or chronic hepatitis virus B, hepatitis virus C, or HIV infection before initiation of systemic cancer therapy. Data were from a multicenter prospective cohort study of 3051 patients with newly diagnosed cancer (SWOG-S1204) enrolled between 2013 and 2017. Patients completed a survey with questions pertaining to personal history and behavioral, socioeconomic, and demographic risk factors for viral hepatitis or HIV. We derived a risk model to predict the presence of viral infection in a random set of 60% of participants using best subset selection. The derived model was validated in the remaining 40% of participants. Logistic regression was used. Results A model with 7 risk factors was identified, and a risk score with 4 levels was constructed. In the validation cohort, each increase in risk level was associated with a nearly threefold increased risk of viral positivity (odds ratio = 2.85, 95% confidence interval = 2.26 to 3.60, P &amp;lt; .001). Consistent findings were observed for individual viruses. Participants in the highest risk group (with &amp;gt;3 risk factors), comprised of 13.4% of participants, were 18 times more likely to be viral positive compared with participants with no risk factors (odds ratio = 18.18, 95% confidence interval = 8.00 to 41.3, P &amp;lt; .001). Conclusions A risk-stratified screening approach using a limited set of questions could serve as an effective strategy to streamline screening for individuals at increased risk of viral infection.
The Therapeutic Agents of the Quinoline Group: Cinchophen, Plasmoquine, Nupercaine, Quinine and Acridine Dyes; the Relation Between Their Chemical Constitution and Pharmacologic Action.
Authors: W. F. von Oettingen
Journal: JAMA (1933)

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Abstract 2839: Abnormalities of Myocardial Systolic Function are related to Cardiac Structural Changes in Patients with Hypertension and Diastolic Dysfunction: The VALIDD Study
Authors: Chung-Lieh Hung, Anil Verma, Akshay Suvas Desai, Amira Hassanein, Gerard Aurigemma, Michael Zile, James D. Thomas, Scott D. Solomon
Journal: Circulation (2008)
Abstract 033: Final Results from One of World’s Largest Population-Based Randomized Interventions on Lifestyle. The Inter99 Study
Authors: Charlotta Pisinger, Rikke Kart Jacobsen, Torben Jørgensen
Journal: Circulation (2013)

Background: unhealthy lifestyle is the most important factor with impact on ischemic heart disease (IHD) and mortality. In general, population-based lifestyle interventions have shown disappointing...
Cell Cycle Gene Sets Coordination In Multiple Myeloma and Plasma Cell Leukemia
Authors: Fedor Kryukov, Ivana Ihnatova, Pavel Nemec, Alexander Schmitz, Julie S Brødker, Malene Krag Kjeldsen, Martin Bøgsted, Hans E Johnsen, Roman Hajek, Karen Dybkaer
Journal: Blood (2013)
A Dictionary of Treatment Including Medical and Surgical Therapeutics.
Authors: Whitla, William, Sir
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bulimia in college women: incidence and recovery rates
Authors: Adam Drewnowski, Doris K. Yee, Dean D. Krahn
Journal: American Journal of Psychiatry (1988)

In a longitudinal survey of college freshmen, the incidence of bulimia nervosa was 4.2 cases per 100 women per year. Prevalence remained stable (2.9%-3.3%) as new cases were offset by partial remissions. Some women continued bulimic behaviors without meeting the DSM-III-R criteria.
Abstract 14128: Abnormalities in Sarcoplasmic Reticulum Ca2+ -Sequestering Proteins in Skeletal Muscle in Humans With Advanced Heart Failure
Authors: Chris Vigna, Russell Tupling, Anthony Verity, Michele Hamilton, Gregg Fonarow, Tamara Horwich, Holly Middlekauff
Journal: Circulation (2011)

Background. In chronic HF, the degree of exercise intolerance is not related to cardiac dysfunction, but is largely attributable to abnormalities of the skeletal muscle. Excitation-contraction (E-C...
Abstract 5460: Promoting Effect of <sup>188</sup> Re Radiation on the L-arginine/nitric Oxide Pathway in the Balloon Injured Rat Abdominal Aortic Arteries
Authors: Guangzhen Zhong, Xinchun Yang, Pengrong Chen, Chaoshu Tang
Journal: Circulation (2008)

This study examined the effect of 188 Re radiation on L-Arginine(L-Arg)/NO pathway in the injured rat abdominal aortic artery and investigated the mechanism involved. Forty-three rats were randomly divided into 4 groups: control (n=10), 14 days after balloon injury without treatment (14B, n=10), 14 days after balloon injury plus radiation (14BR, n=13), radiation only (SR, n=10). Vascular lesions were created in the abdominal aortic arteries by overstretch balloon injury. Arteries were then left untreated or were treated with intra-aortic beta-radiation using 188 Re balloon to deliver 20Gy at 2 mm from the center of the source. Intima/medium(I/M) ratio of the artery were evaluated. Plasma NO, aortic NO generation, L-Arg transport, iNOS activity, iNOS mRNA and protein expression were studied. We found that I/M ratio in 14B group was higher than control (0.558±0.175 vs0.063±0.010, P&lt;0.01), and higher than that in 14BR group (0.080±0.021, P&lt;0.01). Plasma NO in each group was not significantly different with each other. NO generated by aortic artery in 14B group were 177% (P&lt;0.01) higher than control (8.65±2.47μmol/mg protein) and 17% (P&lt;0.05) lower than that in 14BR group. iNOS activity in the 14B group was 44% (P&lt;0.01) higher than control(180±22 pmol.mg protein −1 .min −1 ) and 11%(P&lt;0.05) lower than that in 14BR group. Quantitative RT-PCR showed that iNOS mRNA in 14B group was 290% (P&lt;0.01) higher than control and 19%(P&lt;0.05) lower than that in 14BR group. Immunohistochemistry results showed no iNOS protein expression in control. iNOS protein were similarly expressed in the 14B and 14BR groups (P&gt;0.05). However iNOS protein was strongly expressed in the SR group. Incubated in the KH solution with L-Arg(100μmol/L), L-Arg transport efficacy in 14B group was 248% (P&lt;0.01)higher than control(1.04±0.15pmol.g protein −1 .min −1 ), and 39%(P&lt;0.01) higher than that in 14BR group. In summary, we found 188 Re inhibited neointima hyperplasia and promoted NO generation, iNOS activity and iNOS mRNA expression in the injured artery. However, it decreased L-Arg transport and had no significant influence on iNOS protein expression in the injured artery. Therefore, effect of radiation on the L-Arg/NO pathway explains partly the mechanism of intracoronary radiation.
Abstract 3331: Cardiac-Specific IGF-1 Receptor (IGF-1R) Transgenic Mice Are Protected Against Cardiac Fibrosis and Diastolic Dysfunction in Type 1 Diabetic Cardiomyopathy
Authors: Karina Huynh, Tracey L Julius, Joonwin Tan, Helen Kiriazis, Julie R McMullen, Rebecca H Ritchie
Journal: Circulation (2009)

Human diabetic cardiac disease is characterised by early diastolic dysfunction, often preceding impairments in systolic function. Left ventricular (LV) remodeling such as cardiomyocyte hypertrophy ...
Abstract 553: Human Embryonic Stem Cell-Derived Cardiomyocytes Form Human Myocardium and Improve Cardiac Function in Infarcted Rat Hearts
Authors: Michael A Laflamme, Kent Chen, Chunhui Xu, Mohammad Hassanipour, Chris O'Sullivan, Lila Collins, Kellii Schurb, Elina Minami, Shuichi Ueno, Veronica Muskheli, Joseph Gold, Charles E Murry
Journal: Circulation (2006)

Human embryonic stem cells (hESCs) represent an attractive source for deriving large numbers of definitive and rapidly proliferating human cardiomyocytes for cell-based cardiac repair. Successful a...
Reporting eGFR has benefits
Authors: Charlotte E Bebb, Richard P Burden
Journal: BMJ (2007)

Giles and Fitzmaurice overlooked one of the main aims of the recent guidelines on chronic kidney disease and did not take into account the accepted definition of stages 1 and 2, or the recommendations on screening.1 2 Reducing late referral of people who are heading towards dialysis (and avoiding the associated poor …
Abstract 14697: Percutaneous Coronary Intervention in nonagenarians: Midterm Outcomes and Quality of Life assessment
Authors: Rajesh Ramineni, Robert Chait
Journal: Circulation (2010)

PCI in Nonagenarians: Mid-term outcomes and Quality of Life assessment

Background: As the population ages, the number of nonagenarians is projected to increase at an unprecedented rate. A limited number of studies have demonstrated that these patients can be treated successfully with percutaneous coronary intervention (PCI). As these individuals continue to live longer, a greater number will require myocardial revascularization. However, mid-term clinical and functional benefits of PCI in this cohort of patients have not been clearly defined.

Methods: Between January 2005 and June 2009, 173 patients 90 years and older underwent diagnostic cardiac catheterization of which 93 patients had PCI. There were 48 males (52%) and 45 females (48%) with a mean age of 92.06 years (range: 90-101). Of these patients 24 (26%) presented with a STEMI, 32 (34%) patients with a Non-STEMI, 30 (32%)patients with unstable angina, 2 (2%) patients with stable angina, and 5 (5%) patients were studied for pre-operative risk assessment.

Results: A total of 127 lesions were successfully treated utilizing 102 drug eluting stents and 37 bare metal stents with a mean of 1.5 stents per patient. Post-procedure complications included renal insufficiency in 5 patients (5.6%), congestive heart failure in 6 patients (6.7%) and cardiogenic shock in 2 patients (2.2%). Seventy-seven patients (85.6%) experienced no post-procedure complications. The in-hospital mortality was 7.8% and the actuarial survival was 61.5% ± 5.2% at 24 months and 31.6% ± 6.1% at 48 months. The Short Form 36 Health Survey was administered at follow-up and results demonstrated a quality of life similar to that of the general population corrected for age and gender.

Conclusion: This study clearly demonstrates that PCI in nonagenarians can be accomplished with acceptable hospital mortality, morbidity and excellent mid-term results. Moreover, functional improvement in nonagenarians support an enhanced a quality of life comparable to that of the general population.
The Occurrence of Mutations in PTPN11 and KRAS Is Not Dissimilar in Patients with Indolent Juvenile Myelomonocytic Leukemia (JMML) from Those with Clinically More Aggressive Disease.
Authors: Anupama G. Rao, Phil J. Ancliff, David K. Webb, David C. Linch, Rosemary E. Gale
Journal: Blood (2007)
Epicardial application of cardiac progenitor cells in a 3D-printed gelatin/hyaluronic acid patch preserves cardiac function after myocardial infarction
Authors: Roberto Gaetani, Dries A.M. Feyen, Vera Verhage, Rolf Slaats, Elisa Messina, Karen L. Christman, Alessandro Giacomello, Pieter A.F.M. Doevendans, Joost P.G. Sluijter
Journal: Biomaterials (2015)
Determinants of emergency psychiatric admission for adolescents and adults
Authors: James R. Hillard, Marcia Slomowitz, James Deddens
Journal: American Journal of Psychiatry (1988)

The authors compared correlates of admission for 100 patients older than 18 years and 100 patients younger than 18 evaluated in a psychiatric emergency service. Stepwise linear logistic regression analysis identified a combination of variables that best predicted the odds of hospitalization for each group. For adolescents, these variables, in order of importance, were suicidal tendencies, physical abuse, a primary diagnosis of schizophrenia, age, and number of suicide attempts. For adults, the variables were delusions, aggressive behavior, suicidal tendencies, and a primary diagnosis of schizophrenia or affective disorder. The authors discuss the implications of these findings for acute psychiatric treatment of adolescents.
Abstract 14219: Mass Screening for Atherosclerosis by Carotid Ultrasound Examination: The Heart Attack Prevention Program for You by Arterial Screen for Atherosclerosis Prediction (HAPPY ASAP) Study
Authors: Shaanemeet Singh, Ram Bedi, Puneet Maheshwari, Mahendra P Singh, Aslam Nagra, David Panthagani, Takenori Fukumoto, Georgeanne Lammertin, Ravi Kasliwal, Partho Sengupta, Jagat Narula
Journal: Circulation (2012)

Background: Epidemiological transition has resulted in accelerated prevalence rate of cardiometabolic disease with early age of onset and greater mortality. We performed a population based cross-se...
A Phase II Clinical Trial of Rituximab, Cyclophosphamide, Bortezomib, and Dexamethasone (R-CyBor-D) in Relapsed Low Grade and Mantle Cell Lymphoma
Authors: Allison C. Rosenthal, Amylou Constance Dueck, Katherine Gano, Craig Nichols, Daniel Johnson, Angela Toro, Sravan Nagi Reddy, James L Slack, Jose F Leis, Donald W. Northfelt, P. Leif Bergsagel, Rodger Tiedemann, Patrick B. Johnston, Thomas M Habermann, Thomas E. Witzig, Craig B. Reeder
Journal: Blood (2014)
Abstract 1213: Cardiac Overexpression of Epac1 in Transgenic Mice Protects Heart from Lipopolysaccharide-induced Cardiac Dysfunction and Inhibits JAK-STAT Pathway
Authors: Satoshi Okumura, Yunzhe Bai, Meihua Jin, Sayaka Suzuki, Akiko Kuwae, Reiko Kurotani, Yoshihiro Ishikawa
Journal: Circulation (2007)

The sympathetic nervous system and proinflammatory cytokines are believed to play independent roles in the pathophysiology of heart failure. However, the recent identification of Epac (exchange protein activated by cyclic AMP), a new cyclic AMP-binding protein that directly activates Rap1, have implicated that there may be a potential cross talk between the sympathetic and cytokine signals. In order to examine the role of Epac in cytokine signal to regulate cardiac function, we have generated transgenic mice expressing the human Epac1 gene under the control of alpha-cardiac myosin heavy chain promoter (Epac1-TG), and examined their response in lipopolysaccharide (LPS)-induced cardiac dysfunction, a well established model for sepsis-induced cardiac dysfunction. Sepsis-induced cardiac dysfunction results from the production of proinflammatory cytokines. At baseline, left ventricular ejection fraction (LVEF) was similar (TG vs. NTG, 67±1.7 vs. 69±2.1%, n =7–9). The degree of cardiac hypertrophy (LV(mg)/tibia(mm)) was also similar at 3 months old (TG vs. NTG 4.0±0.1 vs. 4.2±0.1, n =5–6), but it became slightly but significantly greater in Epac1-TG at 5 month old (TG vs. NTG 4.9±0.1 vs. 4.4±0.1, p&lt; 0.05, n =5–7). LPS (5mg/kg) elicited a significant and robust reduction of LVEF in both Epac1-TG and NTG, but the magnitude of this decrease was much less in Epac1-TG at 6 hr after injection (TG vs. NTG 48±2.4 vs. 57±1.8%, p&lt; 0.01, n =6–9). At 24 hr after injection, cardiac function was restored to the baseline in both Epac1-TG and NTG. We also examined the activation of JAK-STAT pathway at 24 hr after injection. The tyrosine phosphorylation of STAT1 (Tyr701) and STAT3 (Tyr705) in LV, which is an indicator of STAT activation, was reduced to a greater degree in Epac1-TG by 31±8.8% ( p&lt; 0.05, n =4) and 29±5.9% ( p&lt; 0.05, n =7), respectively, relative to that in NTG. Taken together, Epac1 protects the heart from the cytokine-induced cardiac dysfunction, at least in part, through the inhibition of the JAK-STAT pathway, suggesting the beneficial role played by sympathetic signal to antagonize proinflammatory cytokine signal in heart failure.