Wegener Granulomatosis
Authors: Larry Greenbaum
Journal: Annals of Internal Medicine (1992)

Letters1 October 1992Wegener GranulomatosisLarry Greenbaum, MDLarry Greenbaum, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-7-619_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editors: I read the review on Wegener granulomatosis by Hoffman and colleagues (1) with great interest. Treatment with trimethoprim sulfamethoxazole (TMP-SMX) may be a useful alternative in selected patients (2, 3), as the following case suggests.A 34-year-old man presented with left nasal obstruction due to a large inverted papilloma. He had extensive nasal surgery. Three months later, he developed migratory arthralgia and arthritis, an 8-kg weight loss, infiltrates on chest radiograph, and rapidly rising blood urea nitrogen (BUN) and creatinine levels. Evidence of granulomatous vasculitis consistent with Wegener granulomatosis was found on the original pathology specimens. In...References1. HoffmanKerrLeavittHallahanLebovicsTravis GGRCRW. Wegener granulomatosis: an analysis of 158 patients. Ann Intern Med. 1992;116:488-98. LinkGoogle Scholar2. Valeriano-MarcetSpiera JH. Treatment of Wegener's granulomatosis with sulfamethoxazole-trimethoprim. Arch Intern Med. 1991;151:1649-52. CrossrefMedlineGoogle Scholar3. FauciHaynesKatzWolff ABPS. Wegener granulomatosis:prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med. 1983;98:76-85. LinkGoogle Scholar4. RobertsCurd DJ. Sulfonamides as antiinflammatory agents in the treatment of Wegener's granulomatosis. Arthritis Rheum. 1990;33:1590-3. CrossrefMedlineGoogle Scholar1. DeRemeeMcDonaldHarrisonColes RTED. Wegener's granulomatosis, anatomic correlates: a proposed classification. Mayo Clin Proc. 1976;51:777-81. MedlineGoogle Scholar2. DeRemee R. The treatment of Wegener's granulomatosis with trimethoprim/sulfamethoxazole: illusion or vision? Arthritis Rheum. 1988;31:1068-72. CrossrefMedlineGoogle Scholar3. GeorgiUlmerGross JMW. Co-trimoxazol bei Wegenerscher granulomatose—eine prospektive studie. Immun Infekt. 1991;19:97-8. MedlineGoogle Scholar4. HoffmanKerrLeavittHallahanLebovicsTravis GGRCRW. Wegener granulomatosis: an analysis of 158 patients. Ann Intern Med. 1992;116:488-98. LinkGoogle Scholar1. HoffmanKerrLeavittHallahanLebovicsTravis GGRCRW. Wegener granulomatosis: an analysis of 158 patients. Ann Intern Med. 1992;116:488-98. LinkGoogle Scholar2. Spodick D. Pericarditis in systemic diseases. Cardiol Clin. 1990;8:709-16. CrossrefMedlineGoogle Scholar1. HoffmanKerrLeavittHallahanLebovicsTravis GGRCRW. Wegener granulomatosis: an analysis of 158 patients. Ann Intern Med. 1992;116:488-98. LinkGoogle Scholar2. NilesPanCollins JGA. Value of antigen-specific radioimmunoassays for measuring anti-neutrophil cytoplasmic antibodies (ANCA) in the differential diagnosis of rapidly progressive glomerulonephritis. J Am Soc Nephrol. 1991;2:27-36. CrossrefMedlineGoogle Scholar3. Cohen TervaertGoldschmedingElema JRJ. Association of autoantibodies to myeloperoxidase with different forms of vasculitis. Arthritis Rheum. 1990;33:1264-72. CrossrefMedlineGoogle Scholar4. JennetteFalk JR. Antineutrophil cytoplasmic autoantibodies and associated diseases: a review. Am J Kidney Dis. 1990;15:517-29. CrossrefMedlineGoogle Scholar1. KerrFauciLeavittFleisherHallahanHoffman GARTCG. Limited prognostic value of antineutrophil cytoplasmic antibody in patients with Wegener's granulomatosis. Arthritis Rheum. 1992;35(S)R5. Google Scholar2. DeRemeeMcDonaldWeiland RTL. Wegener's granulomatosis: observations on treatment with antimicrobial agents. Mayo Clin Proc. 1985;60:27-32. CrossrefMedlineGoogle Scholar3. HoffmanKerrLeavittHallahanLebovicsTravis GGRCRW. Wegener granulomatosis: an analysis of 158 patients. Ann Intern Med. 1992;116:488-98. LinkGoogle Scholar4. FauciWolff AS. Wegener's granulomatosis: studies in eighteen patients and a review of the literature. Medicine 1973;42:535-61. CrossrefGoogle Scholar5. ForstotOverlieNeurfeldHarmonForstot JPGCS. Cardiac complications of Wegener's granulomatosis. Semin Arthritis Rheum. 1980;10:148-54. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Medical Specialists, Inc. Zanesville, OH 43701 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPulmonary VasculitisThe Pulmonary VasculitidesPulmonary VasculitisBiological Formation and Reactions of Hydrazo, Azo and Azoxy GroupsUpdate in the Diagnosis and Management of Pulmonary VasculitisA temporary marker for biological applicationsCotrimoxazole treatment for rheumatoid arthritisBiomedical Application of DyesClinical Conference on Management DilemmasThe treatment of Wegener's granulomatosis 1 October 1992Volume 117, Issue 7Page: 619-621KeywordsArthralgiaArthritisBlood urea nitrogenCreatinineSurgeryThoraxVasculitisWegener granulomatosisWeight loss Issue Published: 1 October 1992 PDF DownloadLoading ...