tbuckley/cabot-search huggingface dataset:
Joint contribution of <i>MC1R</i> and <i>MITF</i> alleles to melanoma risk in the age of polygenic risk scores
Authors: William Bruno
Journal: British Journal of Dermatology (2023)

Journal Article Joint contribution of MC1R and MITF alleles to melanoma risk in the age of polygenic risk scores Get access William Bruno William Bruno Genetics of Rare Cancers, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi X, 16132 Genoa, ItalyDepartment of Internal Medicine and Medical Specialties (DiMI), University of Genoa, Viale Benedetto XV 6, 16132 Genoa, Italy Correspondence: William Bruno. Email: william.bruno@unige.it https://orcid.org/0000-0002-0337-0168 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 188, Issue 6, June 2023, Pages 696–697, https://doi.org/10.1093/bjd/ljad097 Published: 28 March 2023 Article history Received: 16 March 2023 Accepted: 17 March 2023 Published: 28 March 2023 Corrected and typeset: 08 May 2023
Preoperative renal insufficiency predicts postoperative adverse outcomes in a mixed surgical population: a retrospective matched cohort study using the NSQIP database
Authors: Yu-Chen Liao, Chuen-Chau Chang, Chien-Yu Chen, Chih-Chung Liu, Chien-Chang Liao, Yu-Ru Vernon Shih, Chao-Shun Lin
Journal: International Journal of Surgery (2023)

Background: The incidence of chronic kidney disease is increasing, but most cases are not diagnosed until the accidental finding of abnormal laboratory data or the presentation of severe symptoms. Patients with chronic kidney disease are reported to have an increased risk of postoperative mortality and morbidities, but previous studies mainly targeted populations undergoing cardiovascular surgery. The authors aimed to evaluate the risk of postoperative mortality and complications in a surgical population with preoperative renal insufficiency (RI). Materials and Methods: This retrospective cohort study used data from the National Surgical Quality Improvement Program database between 2013 and 2018 to evaluate the risk of postoperative morbidity and mortality in the surgical population. Patients with estimated glomerular filtration rate less than 60 ml/min/1.73 m 2 were defined as the RI group. Propensity score matching methods and multivariate logistic regression were used to calculate the risk of postoperative morbidity and mortality. Results: After propensity score matching, 502 281 patients were included in the RI and non-RI groups. The RI group had a higher risk of 30-day in-hospital mortality (odds ratio: 1.54, 95% CI: 1.49–1.58) than the non-RI group. The RI group was associated with a higher risk of postoperative complications, including myocardial infarction, stroke, pneumonia, septic shock, and postoperative bleeding. The RI group was also associated with an increased risk of prolonged ventilator use for over 48 h, readmission, and reoperation. Conclusion: Patients with preoperative RI have an increased risk of postoperative 30-day mortality and complications. RI group patients with current dialysis, estimated glomerular filtration rate less than or equal to 30 ml/min/1.73 m 2 or concomitant anemia had an elevated risk of postoperative mortality.
Collagen Hydrogel Containing Polyethylenimine‐Gold Nanoparticles for Drug Release and Enhanced Beating Properties of Engineered Cardiac Tissues
Authors: Kaveh Roshanbinfar, Maria Kolesnik‐Gray, Miriam Angeloni, Stefan Schruefer, Maren Fiedler, Dirk W. Schubert, Fulvia Ferrazzi, Vojislav Krstic, Felix B. Engel
Journal: Advanced Healthcare Materials (2023)

Abstract Cardiac tissue engineering is a promising strategy to prevent heart failure. However, several issues remain unsolved, including efficient electrical coupling and incorporating factors to enhance tissue maturation and vascularization. Herein, a biohybrid hydrogel that enhances beating properties of engineered cardiac tissues and allows drug release concurrently is developed. Gold nanoparticles (AuNPs) with different sizes (18–241 nm) and surface charges (33.9–55.4 mV) are synthesized by reducing gold (III) chloride trihydrate using branched polyethyleneimine (bPEI). These nanoparticles increase gel stiffness from ≈91 to ≈146 kPa, enhance electrical conductivity of collagen hydrogels from ≈40 to 49–68 mS cm −1 , and allow slow and steady release of loaded drugs. Engineered cardiac tissues based on bPEI‐AuNP‐collagen hydrogels and either primary or human induced pluripotent stem cell (hiPSC)‐derived cardiomyocytes show enhanced beating properties. hiPSC‐derived cardiomyocytes exhibit more aligned and wider sarcomeres in bPEI‐AuNP‐collagen hydrogels compared to collagen hydrogels. Furthermore, the presence of bPEI‐AuNPs result in advanced electrical coupling evidenced by synchronous and homogenous calcium flux throughout the tissue. RNA‐seq analyses are in agreement with these observations. Collectively, this data demonstrate the potential of bPEI‐AuNP‐collagen hydrogels to improve tissue engineering approaches to prevent heart failure and possibly treat diseases of other electrically sensitive tissues.
POLQ inhibition elicits an immune response in homologous recombination–deficient pancreatic adenocarcinoma via cGAS/STING signaling
Authors: Grace Oh, Annie Wang, Lidong Wang, Jiufeng Li, Gregor Werba, Daniel Weissinger, Ende Zhao, Surajit Dhara, Rosmel E. Hernandez, Amanda Ackermann, Sarina Porcella, Despoina Kalfakakou, Igor Dolgalev, Emily Kawaler, Talia Golan, Theodore H. Welling, Agnel Sfeir, Diane M. Simeone
Journal: Journal of Clinical Investigation (2023)

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy that harbors mutations in homologous recombination-repair (HR-repair) proteins in 20%-25% of cases. Defects in HR impart a specific vulnerability to poly ADP ribose polymerase inhibitors and platinum-containing chemotherapy in tumor cells. However, not all patients who receive these therapies respond, and many who initially respond ultimately develop resistance. Inactivation of the HR pathway is associated with the overexpression of polymerase theta (Polθ, or POLQ). This key enzyme regulates the microhomology-mediated end-joining (MMEJ) pathway of double-strand break (DSB) repair. Using human and murine HR-deficient PDAC models, we found that POLQ knockdown is synthetically lethal in combination with mutations in HR genes such as BRCA1 and BRCA2 and the DNA damage repair gene ATM. Further, POLQ knockdown enhances cytosolic micronuclei formation and activates signaling of cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING), leading to enhanced infiltration of activated CD8+ T cells in BRCA2-deficient PDAC tumors in vivo. Overall, POLQ, a key mediator in the MMEJ pathway, is critical for DSB repair in BRCA2-deficient PDAC. Its inhibition represents a synthetic lethal approach to blocking tumor growth while concurrently activating the cGAS-STING signaling pathway to enhance tumor immune infiltration, highlighting what we believe to be a new role for POLQ in the tumor immune environment.
FDG PET/CT in a Case of Pure Ductal Adenocarcinoma of the Prostate With Osteolytic Metastases and Normal PSA Level
Authors: Aisheng Dong, Xumiao Lin, Yushu Bai, Bo Yang, Shengming Xu
Journal: Clinical Nuclear Medicine (2023)

Abstract Prostatic ductal adenocarcinoma is an uncommon aggressive subtype of prostate carcinoma. It is more likely to present with advanced stage and lower prostate-specific antigen. We describe FDG PET/CT findings in a case of pure prostatic ductal adenocarcinoma with lymph node, bone and lung metastases, normal serum prostate-specific antigen level, and elevated serum carbohydrate antigen 19-9 and carbohydrate antigen 724 levels. The primary tumor, and lymph node and bone metastases were hypermetabolic. All the bone metastases were osteolytic. The multiple lung metastases showed no significant FDG uptake, which may be due to small size.
Highly Sensitive and Omnidirectionally Stretchable Bioelectrode Arrays for In Vivo Neural Interfacing
Authors: Qinyi Zhao, Ming Zhu, Gongwei Tian, Cuiyuan Liang, Zhiyuan Liu, Jianping Huang, Qianheng Yuan Yu, Shuanglong Tang, Jianhui Chen, Xizheng Zhao, Qi Zeng, Chongshen Guo, Dianpeng Qi
Journal: Advanced Healthcare Materials (2023)

Abstract Flexible electrode array, a new‐generation neural microelectrode, is a crucial tool for information exchange between living tissues and external electronics. Till date, advances in flexible neural microelectrodes are limited because of their high impedance and poor mechanical consistency at tissue interfaces. Herein, a highly sensitive and omnidirectionally stretchable polymeric electrode array (PEA) is introduced. Micropyramid–nanowire composite structures are constructed to increase the effective surface area of PEA, achieving an exponential reduction in impedance compared with gold (Au) and flat polypyrrole electrodes. Moreover, for the first time, a suspended umbrella structure to enable PEA with omnidirectional stretchability of up to ≈20% is designed. The PEA can withstand 1000 cycles of mechanical loads without decrease in performance. As a proof of concept, PEA is conformally attached to a rat heart and tibialis anterior muscle, and electrophysiological signals (electrocardiogram and electromyogram) of the rat are successfully recorded. This strategy provides a new perspective toward highly sensitive and omnidirectionally stretchable PEA that can facilitate the practical application of neural electrodes.
NNMT enriches for AQP5<sup>+</sup>cancer stem cells to drive malignant progression in early gastric cardia adenocarcinoma
Authors: Zhangding Wang, Qiang Wang, Chen Chen, Xiaoya Zhao, Honggang Wang, Lei Xu, Yao Fu, Guang Huang, Mengmeng Li, Jiawen Xu, Qianyi Zhang, Bo Wang, Guifang Xu, Lei Wang, Xiaoping Zou, Shouyu Wang
Journal: Gut (2023)

Objective Early gastric cardia adenocarcinoma (EGCA) is a highly heterogeneous cancer, and the understanding of its classification and malignant progression is limited. This study explored the cellular and molecular heterogeneity in EGCA using single-cell RNA sequencing (scRNA-seq). Design scRNA-seq was conducted on 95 551 cells from endoscopic biopsies of low-grade intraepithelial neoplasia, well/moderately/poorly differentiated EGCA and their paired adjacent nonmalignant biopsy samples. Large-scale clinical samples and functional experiments were employed. Results Integrative analysis of epithelial cells revealed that chief cells, parietal cells and enteroendocrine cells were rarely detected in the malignant epithelial subpopulation, whereas gland and pit mucous cells and AQP5 + stem cells were predominant during malignant progression. Pseudotime and functional enrichment analyses showed that the WNT and NF-κB signalling pathways were activated during the transition. Cluster analysis of heterogeneous malignant cells revealed that NNMT-mediated nicotinamide metabolism was enriched in gastric mucin phenotype cell population, which was associated with tumour initiation and inflammation-induced angiogenesis. Furthermore, the expression level of NNMT was gradually increased during the malignant progression and associated with poor prognosis in cardia adenocarcinoma. Mechanistically, NNMT catalysed the conversion of nicotinamide to 1-methyl nicotinamide via depleting S-adenosyl methionine, which led to a reduction in H3K27 trimethylation (H3K27me3) and then activated the WNT signalling pathway to maintain the stemness of AQP5 + stem cells during EGCA malignant progression. Conclusion Our study extends the understanding of the heterogeneity of EGCA and identifies a functional NNMT + /AQP5 + population that may drive malignant progression in EGCA and could be used for early diagnosis and therapy.
Comment to E-Video by Gupta et al.
Authors: Martina De Siena, Ivo Boskoski, Maria Valeria Matteo
Journal: Endoscopy (2023)

See also: Rescuing the impacted endoscopic suturing device during endoscopic sleeve gastroplastyEndoscopy 2022; 54(S 02): E927-E928DOI: 10.1055/a-1858-4499
Endoscopy E-Videos – recently published
Journal: Endoscopy (2023)

Comment on: A novel technique of intraductal ultrasonography using a newly designed endoscopic sheath and Y-connector during endoscopic retrograde cholangiographyEndoscopy 2023; 55(S 01): E159-E160DOI: 10.1055/a-1953-7219 Comment on: Closure of a gastric endoscopic resection defect with a novel closure deviceEndoscopy 2023; 55(S 01): E181-E182DOI: 10.1055/a-1960-3151 Comment on: Preemptive purse-string suturing technique-assisted endoscopic papillectomy of ampullary adenomaEndoscopy 2023; 55(S 01): E167-E168DOI: 10.1055/a-1948-1931 Comment on: Single-balloon-assisted endoscopy with peroral pancreatoscopy and electrohydraulic lithotripsyEndoscopy 2023; 55(S 01): E231-E232DOI: 10.1055/a-1960-3363
Frailty and sarcopenia within the earliest national Dutch childhood cancer survivor cohort (DCCSS-LATER): a cross-sectional study
Authors: Jenneke E van Atteveld, Demi T C de Winter, Vincent G Pluimakers, Marta Fiocco, Rutger A J Nievelstein, Monique G G Hobbelink, Leontien C M Kremer, Martha A Grootenhuis, Heleen Maurice-Stam, Wim J E Tissing, Andrica C H de Vries, Jacqueline J Loonen, Eline van Dulmen-den Broeder, Helena J H van der Pal, Saskia M F Pluijm, Margriet van der Heiden-van der Loo, A Birgitta Versluijs, Marloes Louwerens, Dorine Bresters, Hanneke M van Santen, Imo Hoefer, Sjoerd A A van den Berg, Jaap den Hartogh, Jan H J Hoeijmakers, Sebastian J C M M Neggers, Marry M van den Heuvel-Eibrink
Journal: The Lancet Healthy Longevity (2023)
Effects of periodontitis on cancer outcomes in the era of immunotherapy
Authors: Sara I Pai, Henrique R Matheus, Fernando P S Guastaldi
Journal: The Lancet Healthy Longevity (2023)

Periodontitis results from dysbiosis of the oral microbiome and affects up to 70% of US adults aged 65 years and older. More than 50 systemic inflammatory disorders and comorbidities are associated with periodontitis, many of which overlap with immunotherapy-associated toxicities. Despite the increasing use of immunotherapy for the treatment of cancer, uncertainty remains as to whether the microbial shift associated with periodontal disease can influence response rates and tolerance to cancer immunotherapy. We herein review the pathophysiology of periodontitis and the local and systemic inflammatory conditions related to oral dysbiosis, and discuss the overlapping adverse profiles of periodontitis and immunotherapy. The effects of the presence of Porphyromonas gingivalis, a key pathogen in periodontitis, highlight how the oral microbiome can affect the hosts' systemic immune responses, and further research into the local and systemic influence of other microorganisms causing periodontal disease is necessary. Addressing periodontitis in an ageing population of people with cancer could have potential implications for the clinical response to (and tolerability of) immunotherapy and warrants further investigation.
Safety and pharmacokinetics of escalating doses of neutralising monoclonal antibody CAP256V2LS administered with and without VRC07-523LS in HIV-negative women in South Africa (CAPRISA 012B): a phase 1, dose-escalation, randomised controlled trial
Authors: Sharana Mahomed, Nigel Garrett, Edmund V Capparelli, Farzana Osman, Nonhlanhla N Mkhize, Ishana Harkoo, Tanuja N Gengiah, Leila E Mansoor, Cheryl Baxter, Derseree Archary, Nonhlanhla Yende-Zuma, Natasha Samsunder, Kevin Carlton, Sandeep Narpala, Adrian B McDermott, Nicole A Doria-Rose, Penny L Moore, Lynn Morris, Quarraisha Abdool Karim, John R Mascola, Salim S Abdool Karim
Journal: The Lancet HIV (2023)
Plastic stent replacement after metal stent removal – what about patients with residual walled-off necrosis collections?
Authors: Hannah van Malenstein, Wim Laleman, Schalk W. van der Merwe
Journal: Endoscopy (2023)

See also: Impact of transmural plastic stent on recurrence of pancreatic fluid collection after metal stent removal in disconnected pancreatic duct: a randomized controlled trialEndoscopy 2022; 54(09): 861-868DOI: 10.1055/a-1747-3283 See also: Reply to van Malenstein et al.Endoscopy 2023; 55(04): 396-396DOI: 10.1055/a-1975-0158
Reply to van Malenstein et al.
Authors: Radhika Chavan, Sundeep Lakhtakia, Zaheer Nabi, D. Nageshwar Reddy
Journal: Endoscopy (2023)

See also: Plastic stent replacement after metal stent removal – what about patients with residual walled-off necrosis collections?Endoscopy 2023; 55(04): 395-395DOI: 10.1055/a-1949-0607
Fitusiran prophylaxis in people with severe haemophilia A or haemophilia B without inhibitors (ATLAS-A/B): a multicentre, open-label, randomised, phase 3 trial
Authors: Alok Srivastava, Savita Rangarajan, Kaan Kavakli, Robert Klamroth, Gili Kenet, Liane Khoo, Chur-Woo You, Weiqun Xu, Niel Malan, Laurent Frenzel, Catherine N Bagot, Oleksandra Stasyshyn, Chia-Yau Chang, Stacey Poloskey, Zhiying Qiu, Shauna Andersson, Baisong Mei, Steven W Pipe
Journal: The Lancet Haematology (2023)
Combining endoscopic mucosal resection with hybrid argon plasma coagulation to reduce local colorectal lesion recurrence: a video tutorial
Authors: Melissa Zarandi-Nowroozi, Daniel von Renteln
Journal: Endoscopy (2023)

Endoscopic mucosal resection (EMR) is a safe, effective, and surgery-sparing technique for removing large colorectal lesions [1]. Although piecemeal EMR is recommended for polyps > 20 mm in size, it remains a suboptimal technique for complete lesion resection, with high rates of residual polyp and recurrence rates reaching 15 % [2]. Hybrid argon plasma coagulation (hAPC) is a novel approach allowing ablation of resection margins and surface after EMR. hAPC combines waterjet injection and argon plasma coagulation (APC) in a single device. On-demand, repeatable saline cushioning without instrument exchange reduces thermal ablative insult to deep tissue structures, allowing for effective destruction of micro-remnants with reduced risk of perforation. High technical success and low recurrence rates (0 %) were shown in a pilot study using EMR in combination with hAPC [3]. A prospective international multicenter study showed that the local recurrence rate was only 2.2 % when using hAPC after EMR [4]. One recent meta-analysis found the local recurrence rate to be 3.3 % after hot EMR and margin ablation at 12-month follow-up [5].
Bedaquiline and clofazimine resistance in Mycobacterium tuberculosis: an in-vitro and in-silico data analysis
Authors: Lindsay Sonnenkalb, Joshua James Carter, Andrea Spitaleri, Zamin Iqbal, Martin Hunt, Kerri Marie Malone, Christian Utpatel, Daniela Maria Cirillo, Camilla Rodrigues, Kayzad Soli Nilgiriwala, Philip William Fowler, Matthias Merker, Stefan Niemann, Ivan Barilar, Simone Battaglia, Emanuele Borroni, Angela Pires Brandao, Alice Brankin, Andrea Maurizio Cabibbe, Joshua Carter, Daniela Maria Cirillo, Pauline Claxton, David A Clifton, Ted Cohen, Jorge Coronel, Derrick W Crook, Viola Dreyer, Sarah G Earle, Vincent Escuyer, Lucilaine Ferrazoli, Philip W Fowler, George Fu Gao, Jennifer Gardy, Saheer Gharbia, Kelen Teixeira Ghisi, Arash Ghodousi, Ana Luíza Gibertoni Cruz, Louis Grandjean, Clara Grazian, Ramona Groenheit, Jennifer L Guthrie, Wencong He, Harald Hoffmann, Sarah J Hoosdally, Martin Hunt, Zamin Iqbal, Nazir Ahmed Ismail, Lisa Jarrett, Lavania Joseph, Ruwen Jou, Priti Kambli, Rukhsar Khot, Jeff Knaggs, Anastasia Koch, Donna Kohlerschmidt, Samaneh Kouchaki, Alexander S Lachapelle, Ajit Lalvani, Simon Grandjean Lapierre, Ian F Laurenson, Brice Letcher, Wan-Hsuan Lin, Chunfa Liu, Dongxin Liu, Kerri M Malone, Ayan Mandal, Mikael Mansjö, Daniela Matias, Graeme Meintjes, Flávia de Freitas Mendes, Matthias Merker, Marina Mihalic, James Millard, Paolo Miotto, Nerges Mistry, David Moore, Kimberlee A Musser, Dumisani Ngcamu, Ngoc Nhung Hoang, Stefan Niemann, Kayzad Soli Nilgiriwala, Camus Nimmo, Nana Okozi, Rosangela Siqueira Oliveira, Shaheed Vally Omar, Nicholas Paton, Timothy EA Peto, Juliana Maira Watanabe Pinhata, Sara Plesnik, Zully M Puyen, Marie Sylvianne Rabodoarivelo, Niaina Rakotosamimanana, Paola MV Rancoita, Priti Rathod, Gillian Rodger, Camilla Rodrigues, Timothy C Rodwell, Eaysha Roohi, David Santos-Lazaro, Sanchi Shah, Thomas Andreas Kohl, Grace Smith, Walter Solano, Andrea Spitaleri, Philip Supply, Utkarsha Surve, Sabira Tahseen, Nguyen Thuy Thuong Thuong, Guy Thwaites, Katharina Todt, Alberto Trovato, Christian Utpatel, Annelies Van Rie, Srinivasan Vijay, Timothy M Walker, Sarah A Walker, Robin Warren, Jim Werngren, Maria Wijkander, Robert J Wilkinson, Daniel J Wilson, Penelope Wintringer, Xin Xiao Yu, Yang Yang, Yanlin Zhao, Shen-Yuan Yao, Baoli Zhu
Journal: The Lancet Microbe (2023)

Bedaquiline is a core drug for the treatment of multidrug-resistant tuberculosis; however, the understanding of resistance mechanisms is poor, which is hampering rapid molecular diagnostics. Some bedaquiline-resistant mutants are also cross-resistant to clofazimine. To decipher bedaquiline and clofazimine resistance determinants, we combined experimental evolution, protein modelling, genome sequencing, and phenotypic data.
Endoscopy International Open – recently published
Journal: Endoscopy (2023)

Comment on: Sessile serrated lesion detection rates continue to increase: 2008–2020Endosc Int Open 2023; 11(01): E107-E116DOI: 10.1055/a-1990-0509 Comment on: Comparing size measurement of colorectal polyps using a novel virtual scale endoscope, endoscopic ruler or forceps: A preclinical randomized trialEndosc Int Open 2023; 11(01): E128-E135DOI: 10.1055/a-2005-7548 Comment on: Safety and efficacy of a new cold snare technique with clipping for colorectal angioectasiaEndosc Int Open 2023; 11(02): E157-E161DOI: 10.1055/a-1972-3510
Endovascular treatment versus no endovascular treatment after 6–24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in the Netherlands: a multicentre, open-label, blinded-endpoint, randomised, controlled, phase 3 trial
Authors: Susanne G H Olthuis, F Anne V Pirson, Florentina M E Pinckaers, Wouter H Hinsenveld, Daan Nieboer, Angelique Ceulemans, Robrecht R M M Knapen, M M Quirien Robbe, Olvert A Berkhemer, Marianne A A van Walderveen, Geert J Lycklama à Nijeholt, Maarten Uyttenboogaart, Wouter J Schonewille, P Matthijs van der Sluijs, Lennard Wolff, Henk van Voorst, Alida A Postma, Stefan D Roosendaal, Anouk van der Hoorn, Bart J Emmer, Menno G M Krietemeijer, Pieter-Jan van Doormaal, Bob Roozenbeek, Robert-Jan B Goldhoorn, Julie Staals, Inger R de Ridder, Christiaan van der Leij, Jonathan M Coutinho, H Bart van der Worp, Rob T H Lo, Reinoud P H Bokkers, Ewoud I van Dijk, Hieronymus D Boogaarts, Marieke J H Wermer, Adriaan C G M van Es, Julia H van Tuijl, Hans G J Kortman, Rob A R Gons, Lonneke S F Yo, Jan-Albert Vos, Karlijn F de Laat, Lukas C van Dijk, Ido R van den Wijngaard, Jeannette Hofmeijer, Jasper M Martens, Paul J A M Brouwers, Tomas Bulut, Michel J M Remmers, Thijs E A M de Jong, Heleen M den Hertog, Boudewijn A A M van Hasselt, Anouk D Rozeman, Otto E H Elgersma, Bas van der Veen, Davy R Sudiono, Hester F Lingsma, Yvo B W E M Roos, Charles B L M Majoie, Aad van der Lugt, Diederik W J Dippel, Wim H van Zwam, Robert J van Oostenbrugge
Journal: The Lancet (2023)
Efficacy and safety of fitusiran prophylaxis in people with haemophilia A or haemophilia B with inhibitors (ATLAS-INH): a multicentre, open-label, randomised phase 3 trial
Authors: Guy Young, Alok Srivastava, Kaan Kavakli, Cecil Ross, Jameela Sathar, Chur-Woo You, Huyen Tran, Jing Sun, Runhui Wu, Stacey Poloskey, Zhiying Qiu, Salim Kichou, Shauna Andersson, Baisong Mei, Savita Rangarajan
Journal: The Lancet (2023)
Through-the-scope suture closure of peroral endoscopic myotomy mucosal incision sites: not yet there
Authors: Saif Ullah, Shi Yang
Journal: Endoscopy (2023)

See also: Through-the-scope suture closure of peroral endoscopic myotomy mucosal incision sitesEndoscopy 2023; 55(02): 186-191DOI: 10.1055/a-1890-4917