tbuckley/cabot-search huggingface dataset:
The role of sodium in the uptake of ursodeoxycholic acid in isolated hamster hepatocytes*1, *2
Authors: B BOUSCAREL
Journal: Hepatology (1995)

The uptake of ursodeoxycholic acid (UDCA) was studied in isolated hamster hepatocytes. The uptake was rapid and linear up to 60 seconds for each concentration studied. When the uptake rate was plotted against UDCA concentration, the curve was nonlinear, indicating both saturable and nonsaturable uptake mechanisms. The nonsaturable process had a diffusion constant of 0.01 nmol·s−1·g of cell·μmol/L−1. The saturable component was characterized by a maximum rate of uptake (Vmax) of 5.68 nmol·s−1·g of cell−1 and a Michaelis constant (Km) of 224 μmol/L. In the presence of monensin, ouabain, and amiloride, the uptake of UDCA was significantly decreased by 35% to 55%, whereas the sodium-independent uptake of UDCA was not affected by either monensin or amiloride, thereby confirming sodium dependence of UDCA uptake. The sodium-dependent uptake of UDCA was characterized by a Vmax and a Km of 1.57 nmol·s−1·g of cell−1 and 46 μmol/L, respectively. The rate of uptake of UDCA was maximal at extracellular sodium concentrations ≥20 mmol/L. Furthermore, the uptake of UDCA was competitively inhibited by both taurocholic acid and cholic acid with an inhibitory constant (K1) of 60 μmol/L and 48 μmol/L, respectively. Finally, 1 mmol/L of 4,4′-diisothiocyano-2,2′-disulfonic stilbene (DIDS) inhibited solely the sodium-dependent uptake of cholic acid and UDCA. These findings confirm that the hepatocellular uptake of UDCA involves, at least in part, a sodiumdependent, ouabain, amiloride, and DIDS-sensitive transporter.
Treatment of Syphilis.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Requirements or incentives by government for the use of long-acting contraceptives. Board of Trustees, American Medical Association
Authors: Scott L. Bernstein, Lonnie R. Bristow, John L. Clowe, Mary Ann Contogiannis, Greenville, Greenville, Richard F. Corlin, Nancy W. Dickey, Palma E. Formica, New Brunswick, William E. Jacott, Daniel H. Johnson, Robert E. McAfee, Joseph T. Painter, Thomas R. Reardon, John J. Ring, Raymond Scalettar, Jerald R. Schenken, John P. Seward, C. John Tupper, Frank B. Walker, Percy Wootton, Dick K. Cason, Frederick W. Cheney, Clarence H. Denser, Raymond C. Grandon, Francis X. Lieb, John A. Martin, Eugene S. Ogrod, David Orentlicher, Anita K. Schweickart, David Orentlicher
Journal: JAMA (1992)

Following the approval of the long-acting contraceptive levonorgestrel (the Norplant Contraceptive System) for use by women, government officials have requi-ed or proposed uses of levonorgestrel that are problematic. One court ordered a woman convicted of child abuse to use levonorgestrel as a condition of her probation; legislators have proposed that women on welfare be paid to use levonorgestrel. Court-ordered use of long-acting contraceptives because of child abuse raises serious questions about a person's fundamental rights to refuse medical treatment, to be free of cruel and unusual punishment, and to procreate. The state's compelling interest in protecting children from abuse may be served by less intrusive means than imposing contraception on parents who have committed child abuse. If government benefits were based on the use of long-acting contraceptives, individuals would have to assume a potentially serious health risk before receiving their benefits. Government benefits should not be made contingent on the acceptance of a health risk. (<i>JAMA</i>. 1992;267:1818-1821)
Secretory and Accessory Cell Functions of the Alveolar Macrophage
Authors: Klara Miller, Barry N. Hudspith, Clive Meredith
Journal: Environmental Health Perspectives (1992)

We have attempted to address the requirements necessary for alveolar macrophage accessory cell function. We have also examined the in vitro and in vivo factors that must be taken into account when interpreting results from experimental studies. Differences in phenotypic expression by rat alveolar pleural and peritoneal macrophages are noted, as well as the differing expression of major histocompatibility complex (MHC) class II molecules. Furthermore, alveolar macrophages, harvested from rat lung, do not express the interleukin (IL)-1 cytokines, and lipopolysaccharide (LPS) treatment of quiescent cells (after 24-hr in vitro culture) induces low levels of expression of IL-1 alpha and IL-1 beta. Short-term inhalation of refractory ceramic fibers, however, results in markedly increased IL-1 beta expression after stimulation with LPS. We suggest that, in vivo, IL-1 beta may be involved in the initial recruitment and activation of inflammatory cells rather than in induction of immune responses. We also postulate, based on recent published evidence, that alveolar macrophages activate the dendritic cells within the respiratory epithelium. Thus alveolar macrophages would release cytokines critical for the activation of dendritic cells during the afferent limb of the immune response, and they would respond to products of sensitized T-cells such as interferon-gamma and IL-4 to interact with T-helper cells in an antigen-specific MHC-restricted manner during the efferent limb of the response.
Etched in Twilight
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immune aspects of renal diseases
Authors: C. B. Wilson
Journal: JAMA (1987)

ANIMAL models have long served as an introduction to understanding the possible mechanisms responsible for human immune renal injury. Exploration of these models has refined and expanded our knowledge of the ways in which nephritogenic antigen and antibody interactions can lead to phlogogenic immune deposit formation, mediator activation, and relatively nonselective damage to surrounding renal structures, thereby producing pathophysiological changes.<sup>1,2</sup>In addition, antibody reactions capable of inducing selective glomerular (or tubular) cell damage have been recently defined. Cellular immune reactions are clearly important in tubulointerstitial injury, and studies continue to define cellular immune contributions to glomerular injury. The humoral and cellular mediation pathways that magnify antibody-induced injury are increasingly defined, and the cells of the glomerulus itself are being investigated as contributors of phlogogenic mediator molecules. The elucidation of the mechanisms of human immune renal injury, unfortunately, lags behind the understanding of the experimental models of both glomerulonephritis and
Experience with a modified rubella hemagglutination inhibition antibody test
Authors: L. Z. Cooper
Journal: JAMA (1969)

This report confirms the value of a modification of the rubella hemagglutination inhibition (HI) antibody test which has eliminated the source of a troublesome problem, the random, unpredictable appearance of false positive results caused by inadequate removal of nonspecific serum inhibitors of hemagglutination. The modification consists of pretreating the test sera with a solution of manganese chloride and heparin sodium instead of kaolin suspension. The procedure is also more sensitive, rapid, and convenient, even in the hands of less experienced personnel, and should remove the last technical barrier to widespread availability of laboratory serodiagnosis for rubella. Furthermore, its use with 2-mercaptoethanol extends the range for accurate retrospective diagnosis of recent rubella.
In Reply
Authors: Susan M. Blaney, Stacey L. Berg, Frank Balis, David Poplack
Journal: Journal of Clinical Oncology (2005)

either involved-field radiotherapy or systemic chemotherapy. 6 Similarly, stable disease was defined by no quantitative change in CSF cytology.In other randomized trials of LM, patients with persistently positive CSF cytology following induction therapy would be considered nonresponsive and offered alternative therapy.These comments are not meant to diminish the results of this elegant study, notable for determination of in vitro cytotoxicity, nonhuman primate studies, and pharmacokinetics of MAFOS; rather the comments reflect the difficulty encountered in treating patients with LM and the lack of standardization regarding treatment.
Update: Transmission of HIV Infection During an Invasive Dental Procedure—Florida
Journal: JAMA (1991)

Possible transmission of human immunodeficiency virus (HIV) infection during an invasive dental procedure was previously reported in a young woman (patient A) with acquired immunodeficiency syndrome (AIDS). Patient A had no identified risk factor for HIV infection and was infected with a strain of HIV closely related to that of her dentist as determined by viral DNA sequencing. A follow-up investigation has identified four additional patients of the dentist who are infected with HIV. Laboratory and epidemiologic investigation has been completed on three of these patients; two are infected with strains closely related to those of the dentist and patient A but not to strains from other persons residing in the same geographic area as the dental practice. The follow-up investigation included review of medical records of the dentist and interviews of former staff on the infection-control procedures of the dental practice. This report summarizes the findings of the investigation.
Contents
Authors: M Romero-Gómez, P Deltenre, A Louvet, M Lemoine, A Mourad, L Fartoux, C Moreno, J Henrion, P Mathurin, L Serfaty, C Tillmann, K Patel, A Muir, C Guy, J Li, X Lao, A Thompson, P Clark, S Gardner, J Mchutchison, J Mccarthy, J Nattermann, J Timm, H Nischalke, A Olbrich, M Michalk
Journal: Journal of Hepatology (2011)
EXPERIMENTAL INVESTIGATIONS RELATING TO SURGICAL OPERATIONS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening Blood Donors by Computer Interview
Authors: Fred B. Silberstein
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Locke et al<sup>1</sup>demonstrate that potential blood donors yield more data about personal risk factors for the human immunodeficiency virus (HIV) in private computer interviews than they do in response to written questionnaires and face-to-face encounters. As these authors acknowledge, it is now well recognized that patients respond favorably to computer-assisted interviews. The development of computer risk-assessment techniques is a relatively recent endeavor, and knowledge about the validation process for these instruments is at an embryonic stage. At this time, discussion should explore the nature of experimental methods for assessing the accuracy of these techniques. The conventional measures for reporting the accuracy of diagnostic instruments are sensitivity, specificity, and positive and negative predictive value. One's first impulse is to attempt to estimate these measures for risk assessment techniques. Locke et al claim that their computer interview is "more sensitive" than the traditional method. They promise that
Hemiparesis and Bell's palsy following brachial plexus herpes zoster
Authors: P. G. Economou
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Experimental live influenza vaccine undergoes evaluation
Authors: P. Gunby
Journal: JAMA (1984)

While influenza control policies are being worked out, an experimental live attenuated type A vaccine is being evaluated. Administered intranasally, the experimental vaccine has shown promise in initial clinical trials. But even if this promise is fulfilled, it's expected to be at least the late 1980s before the vaccine could be made available commercially. Reporting the initial trial data (<i>Lancet</i>1984;I:705-708), the investigators—from the universities of Maryland (Baltimore) and Rochester (NY), and the National Institutes of Health (NIH) (Bethesda, Md)— say 81 women and men, 18 to 35 years of age, volunteered for the study. They were divided into three groups, one (41 persons) receiving the experimental vaccine nose drops (three dosages were tested), another (16) receiving a commercially prepared inactivated subvirion vaccine, and the third (24) receiving placebo nose drops. Volunteers of this age were selected because of their apparent low risk of serious complications from influenza. They lived
Rebuilding broken bridges.
Journal: BMJ (1974)

coccal osteomyelitis.Any other supposed indications seem to call for careful reconsideration.Some idea of the doubtful purposes for which lincomycin or clindamycin have been prescribed may be gained from published case histories of patients with this form of colitis.Indications mentioned include acne rosacea," "a superficial skin infection,"'2 "a mild upper respiratory infection,''l3 influenza,'4 dental extraction,'4 planting a pace-maker,2 and cover for operation on a metacarpophalangeal joint.2
<i>Fruit Piece</i>
Authors: M. Therese Southgate
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RESULTS OF CANCER RESEARCH
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diabetes and Endothelial Dysfunction: A Clinical Perspective
Authors: J. Calles-Escandon
Journal: Endocrine Reviews (2001)

The main etiology for mortality and a great percent of morbidity in patients with diabetes mellitus is atherosclerosis. A hypothesis for the initial lesion of atherosclerosis is endothelial dysfunction, defined pragmatically as changes in the concentration of the chemical messengers produced by the endothelial cell and/or by blunting of the nitric oxide-dependent vasodilatory response to acetylcholine or hyperemia. Endothelial dysfunction has been documented in patients with diabetes and in individuals with insulin resistance or at high risk for developing type 2 diabetes. Factors associated with endothelial dysfunction in diabetes include activation of protein kinase C, overexpression of growth factors and/or cytokines, and oxidative stress. Several therapeutic interventions have been tested in clinical trials aimed at improving endothelial function in patients with diabetes. Insulin sensitizers may have a beneficial effect in the short term, but the virtual absence of trials with cardiovascular end-points preclude any definitive conclusion. Two trials offer optimism that treatment with ACE inhibitors may have a positive impact on the progression of atherosclerosis. Although widely used, the effect of hypolipidemic agents on endothelial function in diabetes is not clear. The role of antioxidant therapy is controversial. No data have been published regarding the effects of hormonal replacement therapy on endothelial dysfunction in postmenopausal women with type 2 diabetes.
Study on Tuberculostatic Factor of Mammalian Serum
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Listing.
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal