In This Issue
Journal: Cancer Discovery (2023)

In This Issue| March 01 2023 In This Issue Author & Article Information Online ISSN: 2159-8290 Print ISSN: 2159-8274 ©2023 American Association for Cancer Research2023American Association for Cancer Research Cancer Discov (2023) 13 (3): 517–519. https://doi.org/10.1158/2159-8290.CD-13-3-ITI Related Content This is a related article to: Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced Prostate Cancer Phenotypes This is a related article to: CD19/CD20 Bispecific Chimeric Antigen Receptor (CAR) in Naive/Memory T Cells for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma This is a related article to: NVL-520 Is a Selective, TRK-Sparing, and Brain-Penetrant Inhibitor of ROS1 Fusions and Secondary Resistance Mutations View more This is a related article to: Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha This is a related article to: Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia This is a related article to: Genomic Patterns of Malignant Peripheral Nerve Sheath Tumor (MPNST) Evolution Correlate with Clinical Outcome and Are Detectable in Cell-Free DNA This is a related article to: Detecting Liver Cancer Using Cell-Free DNA Fragmentomes A commentary has been published: A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas This is a related article to: Racial/Ethnic and Sex Differences in Somatic Cancer Gene Mutations among Patients with Early-Onset Colorectal Cancer This is a related article to: Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia This is a related article to: LZTR1 Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL View less See also related Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced Prostate Cancer PhenotypesCancer Phenotype Classification Using ctDNA CD19/CD20 Bispecific Chimeric Antigen Receptor (CAR) in Naive/Memory T Cells for the Treatment of Relapsed or Refractory Non-Hodgkin LymphomaCD19/CD20 CAR-T Cell Therapy for Relapsed/Refractory NHL NVL-520 Is a Selective, TRK-Sparing, and Brain-Penetrant Inhibitor of ROS1 Fusions and Secondary Resistance MutationsNVL-520: Selective ROS1 Inhibitor with G2032R and CNS Activity Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor AlphaDiscovery of Immune–Metabolic Drug Targets Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid LeukemiaMutant NPM1 Hijacks Transcription in AML Genomic Patterns of Malignant Peripheral Nerve Sheath Tumor (MPNST) Evolution Correlate with Clinical Outcome and Are Detectable in Cell-Free DNAGenomic Patterns of MPNST Evolution Predict Prognosis Detecting Liver Cancer Using Cell-Free DNA FragmentomesDetecting Liver Cancer Using Cell-Free DNA Fragmentomes Racial/Ethnic and Sex Differences in Somatic Cancer Gene Mutations among Patients with Early-Onset Colorectal CancerEarly-Onset Colorectal Cancer Genomics by Race/Ethnicity and Sex Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid LeukemiaNPM1c Cooperates with MLL to Drive Oncogenic Gene Expression LZTR1 Mutation Mediates Oncogenesis through Stabilization of EGFR and AXLLZTR1 Mutation Stabilizes EGFR and AXL Oncoproteins commentary A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in CarcinomasA Ubiquitination Cascade Protecting Carcinomas from ISR Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record March 1 2023 Citation In This Issue. Cancer Discov 1 March 2023; 13 (3): 517–519. https://doi.org/10.1158/2159-8290.CD-13-3-ITI Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Differential somatic mutation patterns between race/ethnicity and sex in early-onset colorectal cancer (CRC) have not yet been fully elucidated. Holowatyj and colleagues evaluated 6,903 patients with CRC along with clinical-grade targeted sequencing data from AACR Project GENIE and found that non-Hispanic Black, but not Asian/Pacific, patients with early-onset nonhypermutated tumors had higher adjusted tumor mutation rates compared with non-Hispanic white patients. Differences in FLT4, FBXW7, RNF43, LRP1B, APC, PIK3CA, and ATRX mutation rates between racial/ethnic groups and EP300, KRAS, AXIN2, WRN, BRAF, and LRP1B mutation rates by sex were observed in nonhypermutated early-onset CRC. Overall, these findings provide novel molecular insights into the biology underpinning early-onset CRC disparities. See article, p. 570. To address the issue of antigen escape, Larson and colleagues used T cells enriched for naive and memory phenotypes (TN/MEM cells) and engineered to express a... You do not currently have access to this content.