AB0482 FACTORS AFFECTING QUALITY OF LIFE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS IN 1102 LUPUS PATIENTS FROM THE RUSSIAN FEDERATION (RF), KIRGHIZSTAN AND KAZAKHSTAN
Authors: E. Aseeva, S. Solovyev, G. Koilubaeva, B. Issayeva, S. Glukhova, A. Lila
Journal: Annals of the Rheumatic Diseases (2022)

Background Patients with systemic lupus erythematosus (SLE) have a better survival as compared to decades ago; nevertheless, they still experience a low health-related quality of life (HRQoL). The study of factors affecting the quality of life will improve medical care for patients in future. Objectives The aim of this study was to determine factors affecting quality of life of 1102 Lupus patients (pts) from the Russian Federation (RF), Kirghizstan and Kazakhstan. Methods 1102 SLE pts who fulfilled SLICC 2012 criteria were enrolled into the study. The SLEDAI 2K index activity, SLICC damage index, HRQo L using the LupusQo L (validated for the Russian-speaking population in 2018) and HADS questionnaires were evaluated. Results 400/600/102 Lupus pts from RF, Kirghizstan and Kazakhstan were studied, respectively. The pts were predominantly female (91%/93%/98%) and of indigenous nationality (Russian 83%/ Kirghiz 88%/ Kazakh 76%) with a mean±SD age of 34,2±11,5/35,07±12,2/33,8±10,5 years (p=0,36; p=0,96), respectively. The mean disease duration (Мe) in RF/ Kazakhstan was 6 [3;12]/ 5[2;9] years (p=0,15), in Kirgizstan - 2[0,6; 7] years(p≤0,05). Kazakh pts (p=0,00) have a higher disease activity (SLEDAI 2K) 17,6±8,8 as compared to Kirghiz 15,1±8,3 and Russian 9,4±8,1 pts. SLICC damage index 2,39±1,61 in Kazakh pts (p=0,00) was higher than in Russian 1,57±1,54 and Kirghiz 0,79±0,32 pts. The mean scores for each of the domains of LupusQoL are shown in Figure 1. Figure 1. HRQoL in 1102 Lupus Patients from the Russian Federation (RF), Kirghizstan and Kazakhstan As regards the Sum LupusQoL, 1102 pts were divided into two groups. The first group included 93 pts with SLE with the Sum LupusQoL&lt;20. The second one included 484 pts with SLE with the Sum LupusQoL≥60. Such factors as age, duration of illness before verification of SLE diagnosis, pregnancy, pts without disability, high education, working\ unemployed, SLEDAI 2 К, SLICC damage index, HADS (Т), HADS(D) were included into the analysis. The worst HRQol (Sum LupusQol&lt;20) was associated with older age, duration of illness before verification of SLE diagnosis, unemployed status, high disease activity, organ damage, anxiety and depression (Table 1). Table 1. Factors affecting quality of life in patients with systemic lupus erythematosus in Lupus Patients from Russian Federation, Kirghizstan and Kazakhstan. Factors SumLupusQol&lt;20(n=93) SumLupusQol&gt;60(n=484) P Age, years, (М±SD) 37,06±12,38 30,09±9,96 0,04 Duration of illness before verification of SLE diagnosis, month., Ме [Lower,Upper Quartiles] 36 [12; 84] 10 [4; 24] &lt;0,0001 Pregnancy, n (%) 0 71(14%) 0,002 Pts without disability, n (%) 30(32%) 242(50%) 0,02 High education, n (%) 38(41%) 281(58%) 0,01 Working, n (%) 33(35%) 266(55%) 0,03 Unemployed, n (%) 46(49%) 131(27%) 0,01 SLEDAI 2 К, score, (М±SD) 11,32±8,16 8,50±7,47 0,04 SLICC damage index, score, (М±SD) 1,83±1,72 1,09±0,96 0,004 HADS (Т)≥11, n (%) 30(32%) 19(4%) &lt;0,0001 HADS(D)≥11, n (%) 26 (28%) 1(0,4%) &lt;0,0001 *p &lt;0,05 Mann — Whitney test Much better HRQoL (LupusQol≥60) was associated with younger age, pregnancy, absence of disability, high education, availability of work. Conclusion The most consistent predictors of low HRQoL in SLE Patients from the Russian Federation (RF), Kirghizstan and Kazakhstan are socio-demographic factors such as older age, poverty and lower educational level, working\ unemployed. There are some more important factors such as SLE activity, damage and prevalent comorbidities (anxiety and depression). Disclosure of Interests None declared