tbuckley/cabot-search huggingface dataset:
Washington University and the creation of the teaching hospital
Authors: K. M. Ludmerer
Journal: JAMA (1991)

IT IS common knowledge that during the 20th century the Washington University School of Medicine has exemplified the ideals of the Flexnerian revolution—the marriage of basic science with clinical medicine.<sup>1</sup>Less well known, however, is the fact that in the reorganization of the school in 1910, Washington University left an enduring imprint on the nation's developing system of medical education. The remarkable feature of the reorganization was not that the school acquired a scientifically eminent full-time faculty and built an impressive new physical plant, important as those achievements were. Rather, the singular contribution of the school lay in the success of its leadership in persuading Barnes Hospital, St Louis, Mo, and St Louis (Mo) Children's Hospital to become true teaching hospitals. Before the reorganization, The Johns Hopkins Hospital in Baltimore, Md, was the only large, modern hospital that genuinely encouraged teaching and research within its walls; the lack of
Abstract P106: Dense Low-density and Remnant Lipoprotein Cholesterol are Associated with Adiposity: The Elsa-Brasil Study
Authors: Claudia Suemoto, Isabela M Bensenor, Raul Santos, Marcio S Bittencourt, Seth Martin, Peter Toth, Steven Jones, Michael Blaha, Paulo A Lotufo
Journal: Circulation (2016)

Introduction: Obesity is a known risk factor for coronary heart disease, and this relationship may be mediated by the presence of small dense low-density (LDL-3+LDL-4) and remnant (VLDL-3+IDL) lipoproteins. However, few studies with limited sample sizes have investigated the association of small dense low-density (SDLDL) and remnant lipoproteins (RL) with adiposity. One question is about these markers are only an epiphenomenon of high triglycerides or insulin resistance. Hypothesis: to verify if these associations are mediated by levels of triglycerides and / or insulin resistance Methods: We included 4,189 participants (50.6±8.6 years, 554% women, 58% White) from the ELSA-Brasil study who had no prior history of cardiovascular diseases were not currently using lipid-lowering medications, and had a BMI&gt;18.5kg/m2. We measured the fasting lipoprotein cholesterol fractions using the vertical auto profile ultracentrifugation method. We investigated the association of BMI and WC with SDLDL and RL, using linear regression with a quadratic term for BMI and WC and adjusted for age, gender, HOMA-estimated insulin resistance, and fasting serum triglycerides. Results: The mean LDL-3, LDL-4, VLDL-3, and IDL were respectively (mg/dL): 47.5±20.2, 10.5±10.8, 14.9±5.1, and 17.3±7.8. SDLDL had a quadratic association with BMI (linear:β=2.72, SE=0.53, p&lt;0.0001; quadratic:β=-0.04, SE=0.01, p&lt;0.0001), and WC (linear:β=1.94, SE=0.32, p&lt;0.0001; quadratic:β=-0.01, SE=0.002, p&lt;0.0001). RL showed also a quadratic association, mainly with WC (WC-linear:β=0.40, SE=0.13, p=0.002; quadratic:β=-0.002, SE=0.001, p=0.005; and BMI-linear:β=0.51, SE=0.21, p=0.01; quadratic:β=-0.01, SE=0.003, p=0.03). Conclusion: In a large cohort of asymptomatic individuals, SDLDL and RL were both associated with measures of adiposity. These results occurred independently of plasma triglycerides and insulin resistance.
Erratum for the Research Article: “The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia” by G. Brumatti, C. Ma, N. Lalaoui, N.-Y. Nguyen, M. Navarro, M. C. Tanzer, J. Richmond, M. Ghisi, J. M. Salmon, N. Silke, G. Pomilio, S. P. Glaser, E. de Valle, R. Gugasyan, M. A. Gurthridge, S. M. Condon, R. W. Johnstone, R. Lock, G. Salvesen, A. Wei, D. L. Vaux, P. G. Ekert, J. Silke
Journal: Science Translational Medicine (2017)
Thrombotic thrombocytopenic purpura. A reappraisal
Authors: S. M. Crain
Journal: JAMA (1981)

Thrombotic thrombocytopenic purpura (TTP) is an infrequent, sporadic, and highly fatal syndrome. Recent advances in therapy and insight into the pathogenesis of this disorder have dramatically changed its once poor prognosis. A reappraisal of the diagnosis, pathogenesis, and treatment of TTP is the subject of this article. (<i>JAMA</i>1981;246:1243-1246)
Syllabus
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3308: Bisphenol A treatment induces hyperplasia in primary and stem cell-generated mammary glands from pregnant mice
Authors: Hakim Bouamar, Fuchuang Zhang, Xiang Gu, Qiaoxiang Dong, Lu-Zhe Sun
Journal: Cancer Research (2016)

Abstract Breast cancer is a commonly diagnosed cancer during pregnancy. However, how endogenous and exogenous endocrine factors may contribute to the development of pregnancy-associated mammary tumorigenesis is not clear. There is growing evidence that mammary stem cells (MaSCs) may initiate neoplastic transformation when dysregulated in mouse models. We investigated the effect of the environmental endocrine disruptor bisphenol A (BPA) on mouse mammary gland morphology, epithelial cell composition, pre-neoplastic lesions, and the regenerative function of MaSCs. Pregnant FVB mice with GFP transgene on Day E8.5 were implanted with osmotic pumps that constantly release BPA at 0, 25 or 250 ng/kg/day for 28 days and the mice were euthanized one month after weaning. In agreement with the literature, we observed an abnormality of the morphology of the mammary gland after BPA treatment characterized by higher duct density and abnormal secondary and tertiary branching. Quantification of percent hyperplastic mammary ducts in H&amp;E-stained tissue slides revealed a significant increase of ducts with hyperplastic lesions after BPA treatment, particularly with the low dose. To investigate the effects of BPA treatment on MaSCs, we used enzyme digestion to isolate the CD24hi/CD49f+ luminal epithelial cells (also termed as colony forming cell or CFC) and the CD24+/CD49fhi basal epithelial cells (also termed as mammary repopulating unit or MRU) from mammary gland tissues by FACS and found no significant difference in percent of luminal or basal cell population after BPA treatment. Because the basal cells are enriched with MaSCs that can form mammospheres in suspension culture and subsequently form solid 3D organoids when cultured in Matrigel, we transplanted the solid 3D organoids into cleared mammary fat pads of syngeneic FVB mice and immune-compromised nude mice to examine how BPA treatment might alter MaSC function. Significantly, similar to the results from the primary mammary glands, the regenerated mammary glands by MaSCs from mice treated with the low dose of BPA showed increased duct density, secondary and tertiary branching, and a significantly greater number of hyperplastic lesions. Taken together, our study demonstrated that BPA exposure at very low dose could induce pre-neoplastic lesions in the mammary gland of pregnant mice, apparently by directly targeting MaSCs, and implicates BPA as an exogenous endocrine factor that may promote pregnancy-associated mammary tumorigenesis. Citation Format: Hakim Bouamar, Fuchuang Zhang, Xiang Gu, Qiaoxiang Dong, Lu-Zhe Sun. Bisphenol A treatment induces hyperplasia in primary and stem cell-generated mammary glands from pregnant mice. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3308.
Ethics Consultation
Authors: Lance K. Stell
Journal: Annals of Internal Medicine (1991)

Letters1 May 1991Ethics ConsultationLance K. Stell, PhDLance K. Stell, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-9-807 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:Drs. La Puma and Schiedermayer (1) describe what they clearly hope will become a new clinical subspecialty—ethics consultation. They claim that this new subspecialty addresses a class of distinctive and important clinical problems—ethical dilemmas. They imply that these problems may overmatch the competence of the primary physician. They claim that a body of theoretic knowledge (biomedical ethics) whose academic foundation offers rational guidance for resolving clinical ethical dilemmas has been established. Finally, they claim that a new, rudimentary clinical discipline (ethics consultation) whose practitioners have "demonstrated ability" in resolving ethical dilemmas has been established. Indeed, the authors...Reference1. La PumaSchiedermayer JD. Ethics consultation: skills, roles, and training. Ann Intern Med. 1991;114:155-60. LinkGoogle Scholar1. La PumaSchiedermayer JD. Ethics consultation: skills, roles, and training. Ann Intern Med. 1991;114:155-60. LinkGoogle Scholar2. Purtilo R. Ethics consultation in the hospital. N Engl J Med. 1984;311:983-6. CrossrefMedlineGoogle Scholar3. Siegler M. Ethics committees: decisions by bureaucracy. Hastings Cent Rep. 1986;16:22-4. CrossrefMedlineGoogle Scholar4. Special report: religion and medical ethics. Religious beliefs must be considered in decision making. Medical Ethics Advisor. 1990;6:137-43. Google Scholar1. La PumaSchiedermayer JD. Ethics consultation: skills, roles, and training. Ann Intern Med. 1991;114:155-60. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1991Volume 114, Issue 9Page: 807-808KeywordsBioethics Issue Published: 1 May 1991 PDF DownloadLoading ...
Heteroplasmic Point Mutations of Mitochondrial DNA Affecting Subunit I of Cytochrome c Oxidase in Two Patients With Acquired Idiopathic Sideroblastic Anemia
Authors: Norbert Gattermann, Stefan Retzlaff, Yan-Ling Wang, Götz Hofhaus, Jürgen Heinisch, Carlo Aul, Wolfgang Schneider
Journal: Blood (1997)
Upside-down Scintigrams
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE RADICAL CURE OF HERNIA.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Visualizing human malignant melanoma and metastases. Use of chloroquine analog tagged with iodine 125
Authors: W. H. Beierwaltes
Journal: JAMA (1968)

A<sup>125</sup>I analog of chloroquine was given to three patients with malignant melanoma. Daily assay of radioactivity in blood, cumulative urinary and fecal excretion of redioactivity, and scintillation photoscanning of the patients were done for two weeks. Tissues were removed surgically at intervals of one to two weeks for radioactivity assay and pathologic study. These studies suggest that, with the scintillation scanner, this radioactive analog of quinoline can be used to delineate the extent of the primary melanoma, demonstrate whether palpable lymph nodes contain metastases from the melanoma, and demonstrate metastases to cervical lymph nodes that cannot be seen or palpated. These uses will provide information to the surgeon preoperatively which may aid him in planning his surgical approach.
Nazi Medicine
Authors: Richard S. Panush
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cavalier
Authors: Paul J. Healy
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Senility Reconsidered
Authors: Valery A. Portnoi
Journal: JAMA (1981)

<h3>To the Editor.—</h3> The article "Senility Reconsidered: Treatment Possibilities for Mental Impairment in the Elderly" (1980;244:259) is probably the most comprehensive overview of the state of the art and current thinking about dementia. The presented, easyto-use diagnostic check list will be of great help for physicians who do not regularly see patients requiring thorough examination for organic brain disease. However, a few points, in particular the classification of dementia, should be elaborated. Following suggestions of other authors, presenile dementia and senile dementia are classified as one clinicopathological entity—Alzheimer's disease. However, the current dispute on the value and use of the concept of organic brain syndrome (OBS), with all of its pros and cons, widely discussed in psychiatric literature, is not presented. Alcoholic dementia; posttraumatic, postanoxic, and postinfectious encephalopathies; and dementia supervening on schizophrenia; multiple sclerosis; or Parkinson's disease are treatable, although not always reversible, forms of dementia. The use of
Campylobacter urinary tract infection. Value of the urine Gram's stain
Authors: H. M. Feder
Journal: JAMA (1986)

<i>CAMPYLOBACTER jejuni</i>is a microaerophilic, curved to spiral, gram-negative bacillus. A frequent cause of bacterial diarrhea,<i>C jejuni</i>also causes extraintestinal infections that include sepsis, meningitis, pneumonia, cholecystitis, peritonitis, and prostatitis.<sup>1-3</sup>We report a case of<i>C jejuni</i>urinary tract infection (UTI). <h3>Report of a Case</h3> A 6-year-old girl presented to the Hartford (Conn) Hospital pediatric ambulatory care center with a threeday history of urinary frequency and incontinence. Her urine was described as cloudy and foul smelling. She had had no episodes of diarrhea. Her medical history was significant for multiple symptomatic UTIs that began at 15 months of age. At that time, radiologic studies showed a complete ureteral duplication on the right and bilateral vesicoureteral reflux. At 4 years of age, she underwent bilateral ureteral reimplantations. After surgery, she was asymptomatic until the present episode. On physical examination, she was afebrile and appeared well. She had neither costovertebral
“Safety of nintedanib added to pirfenidone treatment for idiopathic pulmonary fibrosis.” Kevin R. Flaherty, Charlene D. Fell, J. Terrill Huggins, Hilario Nunes, Robert Sussman, Claudia Valenzuela, Ute Petzinger, John L. Stauffer, Frank Gilberg, Monica Bengus and Marlies Wijsenbeek. <i>Eur Respir J</i> 2018; 52: 1800230.
Journal: European Respiratory Journal (2018)
The Oregon Capitation Initiative
Authors: Matthew K. Wynia
Journal: JAMA (1996)

FINANCIAL INCENTIVES that influence physician decision making are unavoidable.<sup>1</sup>Under the traditional fee-for-service system of physician payment, services that provide benefit to the patient also hold the promise of additional revenue for the physician. In conjunction with health insurance, this payment system strongly promotes increased use of resources,<sup>2</sup>and many health economists believe that fee-for-service payment of physicians has been a major contributor to the rapid growth in health care costs in the United States.<sup>3</sup> With annual rates of growth in health care expenditures continuing to outstrip the rate of growth of the economy, business and government have turned to alterations in physicians' financial incentives to assist in limiting health care expenditures.<sup>4</sup>In particular, managed care plans using capitated payments to physicians are becoming more common.<sup>5</sup>Under capitation, in its simplest form, physicians, either individually or in a group, receive a fixed payment
Measuring Countermeasures
Authors: Mike Mitka
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatitis B. Risk of infection from antigen-positive medical personnel and patients
Authors: A. G. Redeker
Journal: JAMA (1975)

IN A COMMUNICATION to the<i>New England Journal of Medicine</i>in September 1971, Chalmers and Alter<sup>1</sup>pointed out that, at least at that time, the degree of risk that hepatitis B antigen-positive health-care personnel represent to their patient contacts was obscure. They further raised the question as to whether or not any restrictions should be imposed on the professional activities of such individuals. The following year, the Committee on Viral Hepatitis of the National Academy of Sciences-National Research Council, having reviewed the available information on this subject, published their initial statement on the "Public Health Implications of the Presence of Hepatitis B Antigen in Human Serum."<sup>2</sup>The Committee did not recommend either the routine antigen testing of any specific professional group or the imposition of any restrictions on the professional activities of individuals known to be antigen-positive. Are we now in a position to consider a different recommendation?