A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer
Authors: Yin Wu, Dhruva Biswas, Ieva Usaite, Mihaela Angelova, Stefan Boeing, Takahiro Karasaki, Selvaraju Veeriah, Justyna Czyzewska-Khan, Cienne Morton, Magdalene Joseph, Sonya Hessey, James Reading, Andrew Georgiou, Maise Al-Bakir, Nicolai J. Birkbak, Gillian Price, Mohammed Khalil, Keith Kerr, Shirley Richardson, Heather Cheyne, Tracey Cruickshank, Gareth A. Wilson, Rachel Rosenthal, Hugo Aerts, Madeleine Hewish, Girija Anand, Sajid Khan, Kelvin Lau, Michael Sheaff, Peter Schmid, Louise Lim, John Conibear, Roland Schwarz, Tom L. Kaufmann, Matthew Huska, Jacqui Shaw, Joan Riley, Lindsay Primrose, Dean Fennell, Allan Hackshaw, Yenting Ngai, Abigail Sharp, Oliver Pressey, Sean Smith, Nicole Gower, Harjot Kaur Dhanda, Kitty Chan, Sonal Chakraborty, Kevin Litchfield, Krupa Thakkar, Jonathan Tugwood, Alexandra Clipson, Caroline Dive, Dominic Rothwell, Alastair Kerr, Elaine Kilgour, Fiona Morgan, Malgorzata Kornaszewska, Richard Attanoos, Helen Davies, Katie Baker, Mathew Carter, Colin R. Lindsay, Fabio Gomes, Fiona Blackhall, Lynsey Priest, Matthew G. Krebs, Anshuman Chaturvedi, Pedro Oliveira, Zoltan Szallasi, Gary Royle, Catarina Veiga, Marcin Skrzypski, Roberto Salgado, Miklos Diossy, Alan Kirk, Mo Asif, John Butler, Rocco Bilancia, Nikos Kostoulas, Mathew Thomas, Mairead MacKenzie, Maggie Wilcox, Apostolos Nakas, Sridhar Rathinam, Rebecca Boyles, Mohamad Tufail, Amrita Bajaj, Keng Ang, Mohammed Fiyaz Chowdhry, Michael Shackcloth, Julius Asante-Siaw, Angela Leek, Nicola Totten, Jack Davies Hodgkinson, Peter Van Loo, William Monteiro, Hilary Marshal, Kevin G. Blyth, Craig Dick, Charles Fekete, Eric Lim, Paulo De Sousa, Simon Jordan, Alexandra Rice, Hilgardt Raubenheimer, Harshil Bhayani, Morag Hamilton, Lyn Ambrose, Anand Devaraj, Hemangi Chavan, Sofina Begum, Silviu I. Buderi, Daniel Kaniu, Mpho Malima, Sarah Booth, Andrew G. Nicholson, Nadia Fernandes, Pratibha Shah, Chiara Proli, John Gosney, Sarah Danson, Jonathan Bury, John Edwards, Jennifer Hill, Sue Matthews, Yota Kitsanta, Jagan Rao, Sara Tenconi, Laura Socci, Kim Suvarna, Faith Kibutu, Patricia Fisher, Robin Young, Joann Barker, Fiona Taylor, Kirsty Lloyd, Jason Lester, Mickael Escudero, Aengus Stewart, Andrew Rowan, Jacki Goldman, Richard Kevin Stone, Tamara Denner, Emma Nye, Maria Greco, Jerome Nicod, Clare Puttick, Katey Enfield, Emma Colliver, Alastair Magness, Chris Bailey, Krijn Dijkstra, Vittorio Barbè, Roberto Vendramin, Judit Kisistok, Mateo Sokac, Jonas Demeulemeester, Elizabeth Larose Cadieux, Carla Castignani, Hongchang Fu, Kristiana Grigoriadis, Claudia Lee, Foteini Athanasopoulou, Crispin Hiley, Lily Robinson, Tracey Horey, Peter Russell, Dionysis Papadatos-Pastos, Sara Lock, Kayleigh Gilbert, Kayalvizhi Selvaraju, Paul Ashford, Oriol Pich, Thomas B. K. Watkins, Sophia Ward, Emilia Lim, Alexander M. Frankell, Christopher Abbosh, Robert E. Hynds, Mariana Werner Sunderland, Karl Peggs, Teresa Marafioti, John A. Hartley, Helen Lowe, Leah Ensell, Victoria Spanswick, Angeliki Karamani, David Moore, Stephan Beck, Olga Chervova, Miljana Tanic, Ariana Huebner, Michelle Dietzen, James R. M. Black, Carlos Martinez Ruiz, Robert Bentham, Cristina Naceur-Lombardelli, Haoran Zhai, Nnennaya Kanu, Francisco Gimeno-Valiente, Supreet Kaur Bola, Ignacio Garcia Matos, Mansi Shah, Felipe Galvez Cancino, Despoina Karagianni, Maryam Razaq, Mita Akther, Diana Johnson, Joanne Laycock, Elena Hoxha, Benny Chain, David R. Pearce, Kezhong Chen, Javier Herrero, Fleur Monk, Simone Zaccaria, Neil Magno, Paulina Prymas, Antonia Toncheva, Monica Sivakumar, Olivia Lucas, Mark S. Hill, Othman Al-Sawaf, Seng Kuong Ung, Sam Gamble, Sophia Wong, David Lawrence, Martin Hayward, Nikolaos Panagiotopoulos, Robert George, Davide Patrini, Mary Falzon, Elaine Borg, Reena Khiroya, Asia Ahmed, Magali Taylor, Junaid Choudhary, Sam M. Janes, Martin Forster, Tanya Ahmad, Siow Ming Lee, Neal Navani, Marco Scarci, Pat Gorman, Elisa Bertoja, Robert C. M. Stephens, Emilie Martinoni Hoogenboom, James W. Holding, Steve Bandula, Ricky Thakrar, James Wilson, Mansi Shah, None Marcos, Vasquez Duran, Maria Litovchenko, Sharon Vanloo, Piotr Pawlik, Kerstin Thol, Babu Naidu, Gerald Langman, Hollie Bancroft, Salma Kadiri, Gary Middleton, Madava Djearaman, Aya Osman, Helen Shackleford, Akshay Patel, Christian Ottensmeier, Serena Chee, Aiman Alzetani, Judith Cave, Lydia Scarlett, Jennifer Richards, Papawadee Ingram, Emily Shaw, John Le Quesne, Alan Dawson, Domenic Marrone, Sean Dulloo, Claire Wilson, Yvonne Summers, Raffaele Califano, Rajesh Shah, Piotr Krysiak, Kendadai Rammohan, Eustace Fontaine, Richard Booton, Matthew Evison, Stuart Moss, Juliette Novasio, Leena Joseph, Paul Bishop, Helen Doran, Felice Granato, Vijay Joshi, Elaine Smith, Angeles Montero, Phil Crosbie, Nicholas McGranahan, Mariam Jamal-Hanjani, Allan Hackshaw, Sergio A. Quezada, Adrian C. Hayday, Charles Swanton
Journal: Nature Cancer (2022)

Abstract Murine tissues harbor signature γδ T cell compartments with profound yet differential impacts on carcinogenesis. Conversely, human tissue-resident γδ cells are less well defined. In the present study, we show that human lung tissues harbor a resident Vδ1 γδ T cell population. Moreover, we demonstrate that Vδ1 T cells with resident memory and effector memory phenotypes were enriched in lung tumors compared with nontumor lung tissues. Intratumoral Vδ1 T cells possessed stem-like features and were skewed toward cytolysis and helper T cell type 1 function, akin to intratumoral natural killer and CD8 + T cells considered beneficial to the patient. Indeed, ongoing remission post-surgery was significantly associated with the numbers of CD45RA − CD27 − effector memory Vδ1 T cells in tumors and, most strikingly, with the numbers of CD103 + tissue-resident Vδ1 T cells in nonmalignant lung tissues. Our findings offer basic insights into human body surface immunology that collectively support integrating Vδ1 T cell biology into immunotherapeutic strategies for nonsmall cell lung cancer.