tbuckley/cabot-search huggingface dataset:
AB1078 SPECTRUM OF INFECTIONS DURING RHEUMATOID ARTHRITIS
Authors: S. Rekik, S. Boussaid, H. Tbini, S. Rahmouni, S. Jemmali, K. Zouaoui, H. Sahli, M. Elleuch
Journal: Annals of the Rheumatic Diseases (2022)

Background Immunosuppression during rheumatoid arthritis (RA) induced by the disease but especially immunomodulatory treatments, is responsible for an increased frequency of infections in these patients. Objectives The purpose of this study is to assess the incidence of infections during RA and to determine their nature and management. Methods A retrospective study over a period of 10 years, including 150 patients with RA. We identified 33 patients who had at least one infectious episode during their follow-up. Results There were 19 women and 14 men. The mean age was 51 years old [39-63]. RA was immunopositive and erosive in all cases. The average disease duration was 8 years. A comorbidity was associated with RA in 14 patients (42%): diabetes in 7 cases, hypertension in 3 cases, ethylism in 2 cases and history of pulmonary tuberculosis in 2 cases. As an extra-articular manifestation, 15% of patients had Sjogren’s syndrome and 18% had pulmonary interstitial fibrosis (3 cases) or pulmonary nodules (3 cases). The most prescribed DMARDs was Methotrexate, prescribed in monotherapy at the average dose of 17.5 mg/week [10-25mg] in 18 cases. The other patients received Methotrexate associated to Hydroxychloroquine in 4 cases, Sulfasalazine in 3 cases and biotherapy in 8 cases. Corticosteroid therapy at an average dose of 7.5 to 15 mg/day was received in 16 cases (48.5%). All infections noted in our population were community acquired. Urinary tract infection was the most common infection noted in 15 cases: pyelonephritis in 3 cases and cystitis in 12 cases. Other infection sites were ENT in 4 cases, bronchopulmonary in 6 cases including 2 cases of tuberculous infection and viral hepatitis (B and C) in 4 cases. Osteo-articular infections were noted in 3 cases: one cervical spondylodiscitis and two septic arthritis. Finally, one case of RA treated with rituximab was complicated by staphylococcal sepsis. Germs causing these infections were identified in 14 cases (42%). Conclusion The risk of infections is increased during RA, this is due to lymphocyte and autoimmune abnormalities but also to treatments and comorbidities that predispose to the emergence of infectious agents. Disclosure of Interests None declared
AB1232 RELATIONSHIP BETWEEN NEW BIOMARKER (IL18 AND IFN GAMMA) WITH DISEASE ACTIVITY SCORES (DAS71 ESR AND DAS71 CRP) IN JUVENILE IDIOPATHIC ARTHRITIS (JIA)
Authors: M. Besar, A. Abd El Salam
Journal: Annals of the Rheumatic Diseases (2022)

Background Juvenile idiopathic arthritis (JIA) is a chronic inflammatory condition lasting ≥6 weeks in children ≤ 16-year-old and characterized by pro-inflammatory cytokines (IL1B, IL6, IL18, and IFN- gamma) as a key cytokine in inflammation. The pathogenesis of JIA are still poorly understood and different theories are implicated. Different disease activity scores aimed at guiding the treatment strategies. Objectives Correlation between new biomarker (IL18 and IFN gamma) with disease activity scores (DAS71 ESR and DAS71 CRP) and how much these biomarkers change with treatment. Methods Prospective nonrandomized study carried on 45 child diagnosed as Juvenile Idiopathic Arthritis (JIA) fulfilling (ILAR)1997 where assessment of the level of IL18, IFN gamma and IL18, IFN-gamma decrement with correlation to disease activity (Juvenile Arthritis Disease Activity Score (JADAS)) and their role as prognostic markers. Results •Serum IL18 and IFN gamma show significant decrease with the end of the study (Figure 1). •The disease activity (JDAS71 ESR), (JDAS71 CRP) has decreased significantly with the end of the study (Table 1). •Serum IL18 show negative correlation with ESR, CRP, JDAS71ESR, JDAS71CRP and IFN gamma level. •Poor response groups show higher level of ESR, JDAS71ESR and IL18 than good response groups. IL18 and IFN-gamma decrement level was statistically significant higher in good response than poor response. Conclusion IL18 and IFN-gamma cytokine and level of decrement are a useful biomarker in predicating the disease activity and response to therapy. References [1]American Academy of Pediatrics, American Academy of Family Physicians, and American College of Physicians, Transitions Clinical Report Authoring Group (2011). Supporting the health care transition from adolescence to adulthood in the medical home. Pediatrics,128(1),182-200. [2]Angeles-Han ST, Ringold S, Beukelman T, 2019 American College of Rheumatology/Arthritis Foundation guideline for the screening, monitoring, and treatment of juvenile idiopathic arthritis-associated uveitis [published online April 25, 2019]. Arthritis Care Res. doi:10.1002/acr.2387. Acknowledgements to working group and my dear professor in our unit and department. Disclosure of Interests None declared
AB1248 CONTRIBUTION OF IMAGING IN THE DIAGNOSIS OF ATRAUMATIC HIP
Authors: M. Yasmine, H. Ferjani, F. Taboubi, W. Triki, D. Ben Nessib, K. Maatallah, D. Kaffel, W. Hamdi
Journal: Annals of the Rheumatic Diseases (2022)

Background Joint pain of the hip in children and adolescents is one of the most frequent symptoms seen by pediatricians, orthopedists, and pediatric rheumatologists, with an annual incidence of 148.1/100 000 [1]. The identification of an etiology for atraumatic hip pain is challenging. Even though imaging findings are often various and nonspecific, they are necessary for an accurate diagnosis. Objectives The main goal of this study is to investigate the contribution of the different imaging techniques in the diagnosis of the hip main in children. Methods We conducted a retrospective study including children and adolescents with atraumatic hip pain recruited from the Kassab institute of orthopedics. Transcribed data included age, sex, and the etiology of the hip disease. We also recorded different imaging techniques performed for the diagnosis: plain radiography, ultrasound (US), Computed tomography (CT) as well as magnetic resonance imaging (MRI). Results The study included 81 patients. There was a male predominance (59.3% boys versus 40.7% girls) with a sex ratio of 1.45. The mean age at diagnosis was 9.9 years [1-16]. The mean disease duration was eight months [0.1-156]. Hip disorders were distributed as follows: Legg-Calvé-Perthes disease (n=3), epiphysiolysis of the femoral head (n=30), transient synovitis of the hip (n=7), septic hip (n=10), tumor (n=4), hip dislocation (n=8), hip dysplasia (n=4), juvenile idiopathic arthritis with coxitis (n=15). The hip X-ray was abnormal in 75.6% of cases. The hip US was performed in 34.2% of the patients and showed abnormalities in most of the cases (88.5%). US findings were as follows: joint effusion (n=26), synovial thickening (n=18), synovitis (n=12), and a positive power Doppler signal (n=7). Seven patients underwent pelvic CT scans. The main findings were joint effusion (n=2), synovial thickening (n=1), and hip dysplasia (n=4). MRI of the hip was carried out in 23 children and was contributive in 91.3% of the cases. The main findings were as follows: joint effusion (n=12), synovitis (n=10), bone marrow edema (n=8), synovial thickening (n=7), nidus (n=3) and tumoral process (n=1). Conclusion Our study showed that hip X-ray and US are the first-line imaging modalities in an atraumatic hip diagnosis. However, in other cases, further investigations may be needed to make an early diagnosis and avoid adverse sequelae. References [1]Yagdiran A, Zarghooni K, Semler JO, Eysel P. Hip Pain in Children. Dtsch Arztebl Int. 2020;117(5):72-82. Disclosure of Interests None declared
Annals Graphic Medicine - Dr. Mom: A Letter to My Intern Self
Authors: Grace E. Farris
Journal: Annals of Internal Medicine (2022)

Web ExclusivesJuly 2022Annals Graphic Medicine - Dr. Mom: A Letter to My Intern SelfFREEGrace E. Farris, MDGrace E. Farris, MDUniversity of Texas, Austin, Texas (G.E.F.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G22-0024 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: University of Texas, Austin, Texas (G.E.F.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G22-0020.Author/Illustrator Information: Grace E. Farris, MD, is an assistant professor of medicine at Dell Medical School at the University of Texas in Austin, Texas. You can view her work at her website: www.farrisgrace.com.About Dr. Mom: In Dr. Mom, physician and cartoonist Grace Farris examines work–life balance while mothering and doctoring. Dr. Mom appears quarterly in Annals Graphic Medicine at Annals.org.This article was published at Annals.org on 28 June 2022. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics July 2022Volume 175, Issue 7Page: W71-W72 ePublished: 28 June 2022 Issue Published: July 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
AB1425 MENTAL DISTRESS AND ITS CONTRIBUTING FACTORS AMONG ADOLESCENTS IN A RHEUMATOLOGY CENTER IN MALAYSIA
Authors: C. R. Ng, X. Y. Ng
Journal: Annals of the Rheumatic Diseases (2022)

Background According to World Health Organization 2021, approximately 1 in 7 from the age group of 10-19 years old encountered mental health conditions [1]. Multiple factors can affect their mental health including their underlying medical conditions and depression may influence both reporting symptoms and response to treatment. This study is to investigate the prevalence of depression among adolescents diagnosed with rheumatic diseases by using CES-D questionnaire and to determine its contributing factors. Objectives To screen for depression by using center for epidemiologic studies depression (CES-D) among adolescents diagnosed with rheumatic diseases and to determine its contributing factors. Methods This was a survey interview. All rheumatology patients from the age group of 12-21 who followed up in rheumatology clinic Hospital Sultan Ismail from March 2020 to December 2021 were identified and interviewed. Demographic data, clinical data and disease duration were identified and the results were analysed by using IBM SPSS Statistics version 20. Results A total of 71 patients were identified. 93% of them were female (66/71) and majority of them were Malay (60.6%). This was followed by Chinese (23.9%), Indian (7%) and others (8.5%). The mean age group was 16 (range from 12 to 21). 85.9% of them were diagnosed to have systemic lupus erythematosus. 5.6% of them were having juvenile idiopathic arthritis followed by 2.8 % for each juvenile dermatomyositis and psoriatic arthritis. The rest of them were having mixed connective tissues disease and rheumatoid arthritis with the percentage of 1.4% for both diseases. 57 .7% of the respondents were having inactive disease during the interview session. From our survey, it showed that 53.5 % of the respondents were considered depressed with the score of 16 points and above according to the cut off point determined by CES-D questionnaire. The statistics showed association in between disease activity with the score of depression by using Chi Square (p&lt;0.015). However, there was no association between the races and the score of depression (p = 0.1, using Chi Square). There was also no association between duration of disease with the score of depression. (p= 0.485, by using independent t-test). Conclusion Our study showed the prevalence of depression amongst adolescents diagnosed with rheumatic diseases are more than 50% and there was an association between depression score and disease activity. Hence, it is recommended to routinely screen for depression among adolescent as it helps to improve their response and compliant to treatment. Treat to target approach must always be implemented by treating physician to keep disease in remission and indirectly helps to reduce emotional distress among patients. References [1]Institute of health Metrics and Evaluation. Global Health Data Exchange (GHDx) Disclosure of Interests None declared
Artificially Intelligent Nanoarray Detects Various Cancers by Liquid Biopsy of Volatile Markers
Authors: Reef Einoch Amor, Assaf Zinger, Yoav Y. Broza, Avi Schroeder, Hossam Haick
Journal: Advanced Healthcare Materials (2022)

Cancer is usually not symptomatic in its early stages. However, early detection can vastly improve prognosis. Liquid biopsy holds great promise for early detection, although it still suffers from many disadvantages, mainly searching for specific cancer biomarkers. Here, a new approach for liquid biopsies is proposed, based on volatile organic compound (VOC) patterns in the blood headspace. An artificial intelligence nanoarray based on a varied set of chemi-sensitive nano-based structured films is developed and used to detect and stage cancer. As a proof-of-concept, three cancer models are tested showing high incidence and mortality rates in the population: breast cancer, ovarian cancer, and pancreatic cancer. The nanoarray has >84% accuracy, >81% sensitivity, and >80% specificity for early detection and >97% accuracy, 100% sensitivity, and >88% specificity for metastasis detection. Complementary mass spectrometry analysis validates these results. The ability to analyze such a complex biological fluid as blood, while considering data of many VOCs at a time using the artificially intelligent nanoarray, increases the sensitivity of predictive models and leads to a potential efficient early diagnosis and disease-monitoring tool for cancer.
Heterologous booster response after inactivated virus BBIBP-CorV vaccination in older people
Authors: Santiago Oviedo Rouco, Pamela E Rodriguez, Esteban A Miglietta, Pablo Rall, María M Gonzalez Lopez Ledesma, Augusto Varese, Carla A Pascuale, Diego S Ojeda, Bianca Mazzitelli, Lautaro Sanchez, Ana Ceballos, Eduardo Perez, Jorge Geffner, Yanina Miragaya, Andrés H Rossi, Andrea V Gamarnik
Journal: The Lancet Infectious Diseases (2022)
Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
Authors: Yifan Zhang, Thomas M. Blomquist, Rebecca Kusko, Daniel Stetson, Zhihong Zhang, Lihui Yin, Robert Sebra, Binsheng Gong, Jennifer S. Lococo, Vinay K. Mittal, Natalia Novoradovskaya, Ji-Youn Yeo, Nicole Dominiak, Jennifer Hipp, Amelia Raymond, Fujun Qiu, Hanane Arib, Melissa L. Smith, Jay E. Brock, Daniel H. Farkas, Daniel J. Craig, Erin L. Crawford, Dan Li, Tom Morrison, Nikola Tom, Wenzhong Xiao, Mary Yang, Christopher E. Mason, Todd A. Richmond, Wendell Jones, Donald J. Johann, Leming Shi, Weida Tong, James C. Willey, Joshua Xu
Journal: Genome biology (2022)

Abstract Background Clinical laboratories routinely use formalin-fixed paraffin-embedded (FFPE) tissue or cell block cytology samples in oncology panel sequencing to identify mutations that can predict patient response to targeted therapy. To understand the technical error due to FFPE processing, a robustly characterized diploid cell line was used to create FFPE samples with four different pre-tissue processing formalin fixation times. A total of 96 FFPE sections were then distributed to different laboratories for targeted sequencing analysis by four oncopanels, and variants resulting from technical error were identified. Results Tissue sections that fail more frequently show low cellularity, lower than recommended library preparation DNA input, or target sequencing depth. Importantly, sections from block surfaces are more likely to show FFPE-specific errors, akin to “edge effects” seen in histology, while the inner samples display no quality degradation related to fixation time. Conclusions To assure reliable results, we recommend avoiding the block surface portion and restricting mutation detection to genomic regions of high confidence.
AB1407 TELERHEUMATOLOGY AND WORKING VISIT: INITIAL MONOCENTRIC EXPERIENCE ON USE OF TELEVISIT IN THE REGULAR FOLLOW-UP.
Authors: F. Cianci, A. Olga, M. Magnani, F. Pignataro, F. Massimo, M. Reta
Journal: Annals of the Rheumatic Diseases (2022)

Background The COVID-19 pandemic shifted most healthcare to remote delivery methods (telehealth technologies including clinical video televisit) to protect patients, clinicians, and hospital staff. Telerheumatology visits were found to be noninferior to in-person visits and are often more time and cost effective for patients. 1 Objectives Description of an initial integration of video televisit in regular follow-up. Methods In cooperation with the ALTEMS Operational Telemedicine Observatory, we built a procedural manual for televisit, whose phases were as much as possible similar to the usual visit scenario. Patients in remission or in mild disease activity at the time of enrolling visit were involved. Clinical characteristics, treatments and televisits’ features were considered for all patients (Table 1). Patient overall satisfaction was evaluated (rating 1 to 5). Table 1. Patients (n.) 74 M/F 27/47 Age (y) median 46.2±13.5 RA n. (%) 19 (25.6) PsA n. (%) 21 (28.3) SpA (%) 13 (17.5) CTD n. (%) 8 (10,4) Vasculitis n. (%) 7 (9.4) Other n. (%) 6 (8.1) b or tsDMARDs n. (%) 20 (62.5) Televisits n. 86 Mean duration (min.) 17±3.5 Satisfaction (1-5) 4.68 Device (PC/smartphone) % 62.5/37.5 Distance saved, mean (km) 77,5 Time travel saved, mean (min.) 66 CO2 saved (kg) 866.71 € saved (per patient) 44,37 Working visit n. (%) 5 (15.6) Results 86 televisits were performed in 74 consecutive patients, with a mean age of 46.2 ± 13.5 years, diagnosed with the most common rheumatic diseases and on chronic immunosuppressive therapy (c-b-ts DMARDs mono or combination therapy). In 5 cases, in-person visit after televisit was required. the average duration of the televisit was 17 ± 3.5 minutes and the average overall satisfaction was 4.68 / 5. The average distance saved (round trip) was 77,5 km, equal to an avoided travel time of 66 minutes and with a total reduction in CO2 production of approximately 866 kg. 5 patients performed video visit from workplace, de facto inventing the “working visit”. Conclusion Telemedicine is going to become an essential element of clinical practice in rheumatology, 2 especially for active, young, and working patients, helping to minimize the overall impact of the disease on QoL, as far as they are properly selected for clinical characteristics and informatic skills. The possibility to attend to televisit from the workplace will reduce the lost working-hours and the need of travel, thus acquiring undoubted social utility. In the near future, the use of televisit should be also extended to vulnerable patients lacking basic informatic resources, with the help of care-givers or dedicated territorial services. References [1]Matsumoto R, Barton JL. Curr Opin Rheum 2021 May; 1;33(3):262-269. doi:0.1097/BOR.0000000000000790. [2] https://www.salute.gov.it/imgs/C_17_pubblicazioni_2129_allegato.pdf ALTEMS = Alta Scuola di Economia e Management dei Sistemi Sanitari Disclosure of Interests None declared
Antibody Response to COVID-19 mRNA Vaccine in Patients With Lung Cancer After Primary Immunization and Booster: Reactivity to the SARS-CoV-2 WT Virus and Omicron Variant
Authors: Rajesh M. Valanparambil, Jennifer Carlisle, Susanne L. Linderman, Akil Akthar, Ralph Linwood Millett, Lilin Lai, Andres Chang, Ashley A. McCook-Veal, Jeffrey Switchenko, Tahseen H. Nasti, Manpreet Saini, Andreas Wieland, Kelly E. Manning, Madison Ellis, Kathryn M. Moore, Stephanie L. Foster, Katharine Floyd, Meredith E. Davis-Gardner, Venkata-Viswanadh Edara, Mit Patel, Conor Steur, Ajay K. Nooka, Felicia Green, Margaret A. Johns, Fiona O'Brein, Uma Shanmugasundaram, Veronika I. Zarnitsyna, Hasan Ahmed, Lindsay E. Nyhoff, Grace Mantus, Michael Garett, Srilatha Edupuganti, Madhusmita Behra, Rustom Antia, Jens Wrammert, Mehul S. Suthar, Madhav V. Dhodapkar, Suresh Ramalingam, Rafi Ahmed
Journal: Journal of Clinical Oncology (2022)

To examine COVID-19 mRNA vaccine-induced binding and neutralizing antibody responses in patients with non-small-cell lung cancer (NSCLC) to SARS-CoV-2 614D (wild type [WT]) strain and variants of concern after the primary 2-dose and booster vaccination.
POS0379 SMARTPHONE-ASSISTED PATIENT-INITIATED CARE VERSUS USUAL CARE IN PATIENTS WITH RHEUMATOID ARTHRITIS AND LOW DISEASE ACTIVITY: A RANDOMIZED CONTROLLED TRIAL
Authors: B. Seppen, J. Wiegel, M. Ter Wee, D. Van Schaardenburg, L. Roorda, M. Boers, M. Nurmohamed, W. H. Bos
Journal: Annals of the Rheumatic Diseases (2022)

Background Most patients with rheumatoid arthritis (RA) visit their rheumatologist every 3-6 months to evaluate their disease activity. This may be inefficient, as research shows that many patients have minimal disease activity. 1 When patients monitor their disease and initiate care at the right moment, they may be able to reduce the number of clinic visits, with a lower health care burden and costs. We developed a smartphone app that allows patients to self-monitor their disease activity through a weekly assessment of patient index data (RAPID-3). Objectives To assess safety (non-inferiority in disease activity, DAS28) and efficacy (reduction in number of visits) of patient-initiated care assisted by a smartphone app compared to usual care. Methods A twelve month, randomized, non-inferiority clinical trial was conducted in RA patients with low disease activity, on stable treatment for at least 6 months prior to entry. Patients were randomized (1:1) to either app supported patient-initiated care with a scheduled follow-up consultation after a year (app-group), or usual care, see Figure 1. The primary outcomes were non-inferiority in terms of change in disease activity (ΔDAS28) after 12 months and the number of consultations with a rheumatologist. The non-inferiority limit was set at 0.5 difference in ΔDAS28 between the groups. Figure 1. Typical routine care versus app-supported self-initiated care. Results 102 of 103 randomized patients completed the study. The mean age was 58, 60 were female and the mean disease duration was 12 years. At baseline mean (SD) DAS28 was 1.67 (0.68) in the app group, and 1.54 (0.72) in the usual care group. After a year, ΔDAS28 was 0.27 in the app group vs 0.35 in the usual care group: the difference in ΔDAS28 was –0.04 in favor of the app group (95%CI –0.39; 0.30) documenting non-inferiority. The number of rheumatologist consultations was significantly lower in the app group: mean (SD) 1.7 (1.8) vs 2.8 (1.4) visits/year; visit rate ratio: 0.62 (95% CI 0.47;0.81, p&lt;0.001). Conclusion Patient-initiated care supported with self-monitoring via a smartphone app was non-inferior to usual care in terms of ΔDAS28 and led to a 38% reduction in rheumatologist consultations rate. References [1]Haugeberg G et al. Ten years of change in clinical disease status and treatment in rheumatoid arthritis: results based on standardized monitoring of patients in an ordinary outpatient clinic in southern Norway. Arthritis Res Ther 2015 Disclosure of Interests Bart Seppen: None declared, Jim Wiegel: None declared, Marieke ter Wee: None declared, Dirkjan van Schaardenburg: None declared, Leo Roorda: None declared, Maarten Boers: None declared, Michael Nurmohamed: None declared, W.H. Bos Grant/research support from: AbbVie sponsored this trial