tbuckley/cabot-search huggingface dataset:
One‐Step Bioprinting of Multi‐Channel Hydrogel Filaments Using Chaotic Advection: Fabrication of Pre‐Vascularized Muscle‐Like Tissues (Adv. Healthcare Mater. 24/2022)
Authors: Edna Johana Bolívar‐Monsalve, Carlos Fernando Ceballos‐González, Carolina Chávez‐Madero, Brenda Guadalupe de la Cruz‐Rivas, Silvana Velásquez Marín, Shirley Mora‐Godínez, Luisa María Reyes‐Cortés, Ali Khademhosseini, Paul S. Weiss, Mohamadmahdi Samandari, Ali Tamayol, Mario Moisés Alvarez, Grissel Trujillo‐de Santiago
Journal: Advanced Healthcare Materials (2022)
Association of Maternal and Paternal Astigmatism With Child Astigmatism in the Hong Kong Children Eye Study
Authors: Ka Wai Kam, Arnold S. H. Chee, Yuzhou Zhang, Rex C. Y. Tang, Jason T. C. Chan, Xiu Juan Zhang, Yu Meng Wang, Ryan C. F. Chan, Wai Kit Chu, Patrick Ip, Alvin L. Young, Clement C. Tham, Chi Pui Pang, Li Jia Chen, Jason C. Yam
Journal: JAMA Network Open (2022)

Importance Parental astigmatism is a factor associated with risk for development of child astigmatism; however, the magnitude of the association has not been determined. Objective To determine the association between parental and child astigmatism. Design, Setting, and Participants This population-based, cross-sectional study included participants from familial trios, each comprising a child aged 6 to 8 years and both parents, recruited from the Hong Kong Children Eye Study. No restriction criteria were set on the children in terms of refractive status. Data were analyzed from February to June 2022. Exposures Cycloplegic autorefraction and autokeratometry were conducted on the children, whereas noncycloplegic autorefraction and autokeratometry were conducted on their parents. The children were categorized into 6 groups on the basis of the severity of astigmatism of both parents. Information on parental education, family income, and children’s outdoor and near work time were obtained by questionnaires. Main Outcomes and Measures The primary outcome was the odds of child astigmatism among the 6 categories of children. Associations of factors with child astigmatism were evaluated by logistic regression analyses. Results A total of 17 124 participants from 5708 trios (2964 boys and 2754 girls) at a mean (SD) age of 7.32 (0.87) years, and 11 416 parents were examined. Astigmatism of 1.0 D or greater in both parents was associated with greater odds of refractive astigmatism (RA) (odds ratio [OR], 1.62; 95% CI, 1.15-2.26) and corneal astigmatism (CA) (OR, 1.94; 95% CI, 1.50-2.50) in the child. The respective ORs increased to 3.10 (95% CI, 1.34-7.21) and 4.31 (95% CI, 1.76-10.55) when both parents had astigmatism 2.0 D or greater. Higher parental astigmatism conferred higher risks for both RA and CA in children ( P for trend &amp;amp;lt;.001). Parental astigmatism was significantly associated with greater odds of corresponding child astigmatism (maternal RA: OR, 0.76; 95% CI, 0.68-0.84; paternal RA: OR, 0.82; 95% CI, 0.74-0.91; maternal CA: OR, 1.70; 95% CI, 1.51-1.93; paternal CA: OR, 1.33; 95% CI, 1.19-1.49). Conclusions and Relevance The findings of this cross-sectional study suggest that parental astigmatism may confer an independent and dose-dependent association with child astigmatism. Children with parents with astigmatism should have early eye examinations for timely detection of astigmatism to facilitate age-appropriate vision correction and visual development.
Annealing High Aspect Ratio Microgels into Macroporous 3D Scaffolds Allows for Higher Porosities and Effective Cell Migration (Adv. Healthcare Mater. 24/2022)
Authors: Alisa C. Suturin, Andreas J. D. Krüger, Kathrin Neidig, Nina Klos, Nina Dolfen, Michelle Bund, Till Gronemann, Rebecca Sebers, Anna Manukanc, Ghazaleh Yazdani, Yonca Kittel, Dirk Rommel, Tamás Haraszti, Jens Köhler, Laura De Laporte
Journal: Advanced Healthcare Materials (2022)
A Photoacoustic Contrast Nanoagent with a Distinct Spectral Signature for Ovarian Cancer Management
Authors: Anna St Lorenz, Abraham S. Moses, Babak Mamnoon, Ananiya A. Demessie, Youngrong Park, Prem Singh, Oleh Taratula, Olena R. Taratula
Journal: Advanced Healthcare Materials (2022)

Abstract Photoacoustic imaging (PAI) has tremendous potential for improving ovarian cancer detection. However, the lack of effective exogenous contrast agents that can improve PAI diagnosis accuracy significantly limits this application. This study presents a novel contrast nanoagent with a specific spectral signature that can be easily distinguished from endogenous chromophores in cancer tissue, allowing for high‐contrast tumor visualization. Constructed as a 40 nm biocompatible polymeric nanoparticle loaded with two naphthalocyanine dyes, this agent is capable of efficient ovarian tumor accumulation after intravenous injection. The developed nanoagent displays a spectral signature with two well‐separated photoacoustic peaks of comparable PA intensities in the near‐infrared (NIR) region at 770 and 860 nm, which remain unaffected in cancer tissue following systemic delivery. In vivo experiments in mice with subcutaneous and intraperitoneal ovarian cancer xenografts validate that this specific spectral signature allows for accurate spectral unmixing of the nanoagent signal from endogenous contrast in cancer tissue, allowing for sensitive noninvasive cancer diagnosis. In addition, this nanoagent can selectively eradicate ovarian cancer tissue with a single dose of photothermal therapy by elevating the intratumoral temperature to ≈49 °C upon exposure to NIR light within the 700–900 nm range.
Safety and Success Rates of Excimer Laser Sheath–Assisted Retrieval of Embedded Inferior Vena Cava Filters
Authors: Kush R. Desai, John Kaufman, Parker Truong, Jonathan D. Lindquist, Osman Ahmed, Siobhan M. Flanagan, Mark J. Garcia, Rashmi Ram, Yu-Rong Gao, Robert J. Lewandowski, Robert K. Ryu
Journal: JAMA Network Open (2022)

Despite historically high rates of use, most inferior vena cava (IVC) filters are not retrieved. The US Food and Drug Administration safety communications recommended retrieval when the IVC filter is no longer indicated out of concern for filter-related complications. However, failure rates are high when using standard techniques for retrieval of long-dwelling filters, and until recently, there have been no devices approved for retrieval of embedded IVC filters.To evaluate the safety and success of excimer laser sheath-assisted retrieval of embedded IVC filters.A retrospective, multicenter, clinical cohort study of excimer laser sheath-assisted IVC filter retrievals from 7 US sites was conducted between March 1, 2012, and February 28, 2021, among 265 patients who underwent IVC filter retrieval using the laser. Patients were substratified between a high-volume single center and a multicenter data set. A blinded physician committee adjudicated reported complications and their association with use of the laser.Retrieval of IVC filters using excimer laser sheath.The primary safety end point was device-related major complication rate (Society of Interventional Radiology categories C to F, which included any adverse event associated with morbidity or disability that increases the level of care, results in hospital admission, or substantially lengthens the hospital stay). The primary success end point was technical success of IVC filter retrieval. The primary end points were compared with literature-derived, meta-analysis-suggested target performance goals.The single-center experience included 139 participants (mean [SD] age, 52 [16] years; 78 female participants [56.1%]), and the multicenter experience included 126 participants (mean [SD] age, 52 [16] years; 75 female participants [59.5%]). The device-related major complication rate was 2.9% (4 of 139; 95% CI, 0.8%-7.2%; P = .001) for the single-center experience and 4.0% (5 of 126; 95% CI, 1.3%-9.0%; P = .01) for the multicenter experience, both of which were significantly lower than the primary safety performance goal (10%). No major complications were considered to be definitively associated with use of the laser. The technical success rate was 95.7% (133 of 139; 95% CI, 90.8%-98.4%; P = .007) for the single-center experience and 95.2% (120 of 126; 95% CI, 89.9%-98.2%; P = .02) for the multicenter experience, both of which were significantly higher than the primary performance goal (89.4%).This cohort study demonstrated high technical success and low complication rates of excimer laser sheath-assisted retrieval of embedded IVC filters in centers with variable case volume and experience, which suggests a wide applicability of the technique with proper training. The excimer laser sheath offers physicians a valuable tool for retrieval of challenging embedded IVC filters.
Large‐Scale Production of Wholly Cellular Bioinks via the Optimization of Human Induced Pluripotent Stem Cell Aggregate Culture in Automated Bioreactors (Adv. Healthcare Mater. 24/2022)
Authors: Debbie L. L. Ho, Stacey Lee, Jianyi Du, Jonathan D. Weiss, Tony Tam, Soham Sinha, Danielle Klinger, Sean Devine, Art Hamfeldt, Hope T. Leng, Jessica E. Herrmann, Mengdi He, Lee G. Fradkin, Tze Kai Tan, David Standish, Peter Tomasello, Donald Traul, Noushin Dianat, Rukmini Ladi, Quentin Vicard, Kishore Katikireddy, Mark A. Skylar‐Scott
Journal: Advanced Healthcare Materials (2022)
18F-FDG PET/CT Findings of Leptomeningeal Metastasis in Nasopharyngeal Carcinoma
Authors: Matthew Montanarella, Kimberly Boldig, Patrick Natter, Savas Ozdemir
Journal: Clinical Nuclear Medicine (2022)

Nasopharyngeal carcinoma (NC) is an epithelial tumor with distinctive prevalence in East and Southeast Asia. Most patients with NC only experience regional metastasis. In cases of distant metastasis, prognosis is grim. Leptomeningeal spread of the disease is a rare occurrence, which is sparsely described in the literature. We present a case of a 33-year-old man with a history of high-grade NC with leptomeningeal metastasis. Initial MRI lumbar spine demonstrated subtle findings consistent with leptomeningeal disease. These findings are easily discernible on 18 F-FDG PET/CT.
Impact of Neck PET/CT Positivity on Survival Outcomes—Visual and Quantitative Assessment
Authors: Brendan C. Stack, Fenghai Duan, Justin Romanoff, JoRean D. Sicks, Rathan M. Subramaniam, Val J. Lowe
Journal: Clinical Nuclear Medicine (2022)

Introduction FDG PET/CT was prospectively studied in 287 cN0 head and neck cancer patients in ACRIN 6685, and additional analysis of neck FDG uptake upon recurrence-free survival (RFS) and overall survival (OS) was performed. Patients and Methods Two hundred eight had analyzable data. Survival analysis was performed to compare RFS and OS based on neck FDG visual assessment (VA) and SUV max . For SUV max , the optimal thresholds were calculated using conditional inference trees on a randomly selected 70% training data set and validated using the remaining 30% of data. Kaplan-Meier curves with log-rank tests were generated for the patient groups based on VA and optimal SUV max thresholds, and the hazards ratios (HRs) and 95% confidence intervals (CIs) were also calculated. Hypothesis testing was set at a significance level of 0.05. Results A total of 73.9% of bilateral cN0 and 50.0% of unilateral cN0 were alive at the end of the study with the remaining being dead or lost to follow-up. Overall survival median follow-up time was 24.0 months (interquartile range, 15.8–25.3; range, 0–37.0). A total of 63.3% of bilateral cN0 and 42.5% of unilateral cN0 patients remained disease free during the study. Recurrence-free survival median follow-up time was 23.9 months (interquartile range, 12.4–25.2; range, 0–35.6). Visual assessment of necks by our panel of radiologists was significantly associated with RFS (HR [95% CI], 2.30 [1.10–4.79]; P = 0.02), but not with OS (HR [95% CI], 1.64 [0.86–3.14]; P = 0.13). The optimal SUV max thresholds were 2.5 for RFS and 5.0 for OS. For SUV max assessment, applying the optimal thresholds to the 30% test data yielded HRs (95% CIs) of 2.09 (0.61–7.14; P = 0.23) for RFS and 3.42 (1.03–11.41; P = 0.03) for OS. The SUV max threshold of 5.0 was significantly associated with RFS (HR [95% CI], 5.92 [1.79–19.57]; P &lt; 0.001). Conclusions Neck FDG uptake by VA is significant for RFS. An SUV max threshold of 5.0 is significantly associated with OS and RFS.
Neutrophils and macrophages drive TNF-induced lethality via TRIF/CD14-mediated responses
Authors: Hayley I. Muendlein, Wilson M. Connolly, James Cameron, David Jetton, Zoie Magri, Irina Smirnova, Edouard Vannier, Xudong Li, Amanda J. Martinot, Rebecca Batorsky, Alexander Poltorak
Journal: Science Immunology (2022)

TNF mediates a variety of biological processes including cellular proliferation, inflammatory responses, and cell death and is therefore associated with numerous pathologies including autoinflammatory diseases and septic shock. The inflammatory and cell death responses to TNF have been studied extensively downstream of TNF-R1 and are believed to rely on the formation of proinflammatory complex I and prodeath complex II, respectively. We recently identified a similar multimeric complex downstream of TLR4, termed the TRIFosome, that regulates inflammation and cell death in response to LPS or Yersinia pseudotuberculosis . We present evidence of a role for the TRIFosome downstream of TNF-R1, independent of TLR3 or TLR4 engagement. Specifically, TNF-induced cell death and inflammation in murine macrophages were driven by the TLR4 adaptor TRIF and the LPS co-receptor CD14, highlighting an important role for these proteins beyond TLR-mediated immune responses. Via immunoprecipitation and visualization of TRIF-specific puncta, we demonstrated TRIF- and CD14-dependent formation of prodeath and proinflammatory complexes in response to TNF. Extending these findings, in a murine TNF–induced sepsis model, TRIF and CD14 deficiency decreased systemic inflammation, reduced organ pathology, and improved survival. The outcome of TRIF activation was cell specific, because TNF-induced lethality was mediated by neutrophils and macrophages responding to TNF in a TRIF-dependent manner. Our findings suggest that in addition to their crucial role in TNF production, myeloid cells are central to TNF toxicity and position TRIF and CD14 as universal components of receptor-mediated immune responses.
Flotetuzumab and other T-cell immunotherapies upregulate MHC class II expression on acute myeloid leukemia cells
Authors: Joseph C. Rimando, Ezhilarasi Chendamarai, Michael P. Rettig, Reyka Jayasinghe, Matthew J. Christopher, Julie K. Ritchey, Stephanie Christ, Miriam Y. Kim, Ezio Bonvini, John F. DiPersio
Journal: Blood (2022)
Structural and biological engineering of 3D hydrogels for wound healing
Authors: Mohammad Hadi Norahan, Sara Cristina Pedroza-González, Mónica Gabriela Sánchez-Salazar, Mario Moisés Álvarez, Grissel Trujillo de Santiago
Journal: Bioactive Materials (2022)

Chronic wounds have become one of the most important issues for healthcare systems and are a leading cause of death worldwide. Wound dressings are necessary to facilitate wound treatment. Engineering wound dressings may substantially reduce healing time, reduce the risk of recurrent infections, and reduce the disability and costs associated. In the path of engineering of an ideal wound dressing, hydrogels have played a leading role. Hydrogels are 3D hydrophilic polymeric structures that can provide a protective barrier, mimic the native extracellular matrix (ECM), and provide a humid environment. Due to their advantages, hydrogels (with different architectural, physical, mechanical, and biological properties) have been extensively explored as wound dressing platforms. Here we describe recent studies on hydrogels for wound healing applications with a strong focus on the interplay between the fabrication method used and the architectural, mechanical, and biological performance achieved. Moreover, we review different categories of additives which can enhance wound regeneration using 3D hydrogel dressings. Hydrogel engineering for wound healing applications promises the generation of smart solutions to solve this pressing problem, enabling key functionalities such as bacterial growth inhibition, enhanced re-epithelialization, vascularization, improved recovery of the tissue functionality, and overall, accelerated and effective wound healing.
A nanobody against the VWF A3 domain detects ADAMTS13-induced proteolysis in congenital and acquired VWD
Authors: Claire Kizlik-Masson, Ivan Peyron, Stéphane Gangnard, Gaelle Le Goff, Solen M Lenoir, Sandra Damodaran, Marie Clavel, Stéphanie Roullet, Véronique Regnault, Antoine Rauch, Flavien Vincent, Emmanuelle Jeanpierre, Annabelle Dupont, Catherine Ternisien, Thibault Donnet, Olivier D. Christophe, Eric van Belle, Cécile V. Denis, Caterina Casari, Sophie Susen, Peter J. Lenting
Journal: Blood (2022)
Proteogenomic landscape of human pancreatic ductal adenocarcinoma in an Asian population reveals tumor cell-enriched and immune-rich subtypes
Authors: Do Young Hyeon, Dowoon Nam, Youngmin Han, Duk Ki Kim, Gibeom Kim, Daeun Kim, Jingi Bae, Seunghoon Back, Dong-Gi Mun, Inamul Hasan Madar, Hangyeore Lee, Su-Jin Kim, Hokeun Kim, Sangyeop Hyun, Chang Rok Kim, Seon Ah Choi, Yong Ryoul Kim, Juhee Jeong, Suwan Jeon, Yeon Woong Choo, Kyung Bun Lee, Wooil Kwon, Seunghyuk Choi, Taewan Goo, Taesung Park, Young-Ah Suh, Hongbeom Kim, Ja-Lok Ku, Min-Sik Kim, Eunok Paek, Daechan Park, Keehoon Jung, Sung Hee Baek, Jin-Young Jang, Daehee Hwang, Sang-Won Lee
Journal: Nature Cancer (2022)
Effect of a Biopsychosocial Intervention or Postural Therapy on Disability and Health Care Spending Among Patients With Acute and Subacute Spine Pain
Authors: Niteesh K. Choudhry, Sheila Fifer, Constance P. Fontanet, Kristin R. Archer, Ellen Sears, Gauri Bhatkhande, Nancy Haff, Roya Ghazinouri, Rogelio A. Coronado, Byron J. Schneider, Susan W. Butterworth, Harvinder Deogun, Angelina Cooper, Eugene Hsu, Shannon Block, Claudia A. Davidson, Claude E. Shackelford, Parul Goyal, Arnold Milstein, Katherine Crum, Jennifer Scott, Keith Marton, Flavio M. Silva, Sarah Obeidalla, Payton E. Robinette, Mario Lorenzana-DeWitt, Courtney A. Bair, Hana J. Sadun, Natalie Goldfield, Luke M. Hogewood, Emma K. Sterling, Cole Pickney, Emma J. Koltun-Baker, Andrew Swehla, Vishvaas Ravikumar, Sameeksha Malhotra, Sabrina T. Finney, Lynn Holliday, Karin C. Moolman, Shanita Coleman-Dockery, Ilaben B. Patel, Federica B. Angel, Jennifer K. Green, Kevin Mitchell, Mary R. McBean, Muteeb Ghaffar, Sandra R. Ermini, Ana L. Carr, James MacDonald
Journal: JAMA (2022)

Low back and neck pain are often self-limited, but health care spending remains high.
Risk factors for disease progression in fibrotic hypersensitivity pneumonitis
Authors: Hajime Fujimoto, Taro Yasuma, Corina N. D'Alessandro-Gabazza, Esteban C. Gabazza, Osamu Hataji, Tetsu Kobayashi
Journal: European Respiratory Journal (2022)

<b>Awareness of the risk factors for disease progression in hypersensitivity pneumonitis will be very useful as a guide to deciding therapeutic approaches for this devastating disease in real world clinical practice</b>https://bit.ly/3xG4B16
Identifying and appraising outcome measures for severe asthma: a systematic review
Authors: Anna Rattu, Ekaterina Khaleva, Chris Brightling, Sven-Erik Dahlén, Apostolos Bossios, Louise Fleming, Kian Fan Chung, Erik Melén, Ratko Djukanovic, Rekha Chaudhuri, Andrew Exley, Gerard H. Koppelman, Arnaud Bourdin, Franca Rusconi, Celeste Porsbjerg, Courtney Coleman, Clare Williams, Hanna Nielsen, Elizabeth Davin, Phil Taverner, Sofia Romagosa Vilarnau, Graham Roberts
Journal: European Respiratory Journal (2022)

Valid outcome measures are imperative to evaluate treatment response, yet the suitability of existing end-points for severe asthma is unclear. This review aimed to identify outcome measures for severe asthma and appraise the quality of their measurement properties.A literature search was performed to identify "candidate" outcome measures published between 2018 and 2020. A modified Delphi exercise was conducted to select "key" outcome measures within healthcare professional, patient, pharmaceutical and regulatory stakeholder groups. Initial validation studies for "key" measures were rated against modified quality criteria from COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN). The evidence was discussed at multi-stakeholder meetings to ratify "priority" outcome measures. Subsequently, four bibliographic databases were searched from inception to 20 July 2020 to identify development and validation studies for these end-points. Two reviewers screened records, extracted data, assessed their methodological quality and graded the evidence according to COSMIN.96 outcome measures were identified as "candidates", 55 as "key" and 24 as "priority" for severe asthma, including clinical, healthcare utilisation, quality of life, asthma control and composite. 32 studies reported measurement properties of 17 "priority" end-points from the latter three domains. Only the Severe Asthma Questionnaire and Childhood Asthma Control Test were developed with input from severe asthma patients. The certainty of evidence was "low" to "very low" for most "priority" end-points across all measurement properties and none fulfilled all quality standards.Only two outcome measures had robust developmental data for severe asthma. This review informed development of core outcome measures sets for severe asthma.
Integrative genomic analysis of childhood acute lymphoblastic leukaemia lacking a genetic biomarker in the UKALL2003 clinical trial
Authors: Claire Schwab, Ruth E. Cranston, Sarra L. Ryan, Ellie Butler, Emily Winterman, Zoe Hawking, Matthew Bashton, Amir Enshaei, Lisa J. Russell, Zoya Kingsbury, John F. Peden, Emilio Barretta, James Murray, Jude Gibson, Andrew C. Hinchliffe, Robert Bain, Ajay Vora, David R. Bentley, Mark T. Ross, Anthony V. Moorman, Christine J. Harrison
Journal: Leukemia (2022)

Abstract Incorporating genetics into risk-stratification for treatment of childhood B-progenitor acute lymphoblastic leukaemia (B-ALL) has contributed significantly to improved survival. In about 30% B-ALL (B-other-ALL) without well-established chromosomal changes, new genetic subtypes have recently emerged, yet their true prognostic relevance largely remains unclear. We integrated next generation sequencing (NGS): whole genome sequencing (WGS) ( n = 157) and bespoke targeted NGS (t-NGS) ( n = 175) (overlap n = 36), with existing genetic annotation in a representative cohort of 351 B-other-ALL patients from the childhood ALL trail, UKALL2003. PAX5 alt was most frequently observed ( n = 91), whereas PAX5 P80R mutations ( n = 11) defined a distinct PAX5 subtype. DUX4 -r subtype ( n = 80) was defined by DUX4 rearrangements and/or ERG deletions. These patients had a low relapse rate and excellent survival. ETV6::RUNX1 -like subtype ( n = 21) was characterised by multiple abnormalities of ETV6 and IKZF1 , with no reported relapses or deaths, indicating their excellent prognosis in this trial. An inferior outcome for patients with ABL-class fusions ( n = 25) was confirmed. Integration of NGS into genomic profiling of B-other-ALL within a single childhood ALL trial, UKALL2003, has shown the added clinical value of NGS-based approaches, through improved accuracy in detection and classification into the range of risk stratifying genetic subtypes, while validating their prognostic significance.