tbuckley/cabot-search huggingface dataset:
To sleep, perchance to dream
Authors: Robert Stirrups
Journal: The Lancet Neurology (2023)

Dreams have fascinated humanity for centuries; they have inspired art and ancient prophesies, and even today there are many unanswered scientific questions about the nature of sleep and dreams. When faced with these mysteries, many artists turn to science for an explanation of the function of both sleep and dreams, and likewise scientists might turn to art in pursuit of their subjective meaning. This two-way relationship between art and science is a central motif of Sleep and Dreams: Music, Neuroscience, and Stories of Slumber, a collaborative event produced by the San Francisco Conservatory of Music, the University of California San Francisco (UCSF) Department of Neurology, and The Nocturnists, a group who produce podcasts and live shows about the experiences of health-care workers.
The role of skin ultrasound in systemic sclerosis: looking below the surface to understand disease evolution
Authors: Gemma Lepri, Michael Hughes, Yannick Allanore, Christopher P Denton, Daniel E Furst, Yukai Wang, Tânia Santiago, Ilaria Galetti, Francesco Del Galdo, Dinesh Khanna, Marco Matucci-Cerinic
Journal: The Lancet Rheumatology (2023)
Can we stop routine biopsy of post-endoscopic mucosal resection scars?
Authors: Nicholas G. Burgess, Michael J. Bourke
Journal: Endoscopy (2023)

Corrected by: Correction: Can we stop routine biopsy of post-endoscopic mucosal resection scars?Endoscopy 2023; 55(07): C4-C4DOI: 10.1055/a-2106-6895
The dearth of disaggregated health data: a political rather than a technical challenge
Authors: Kent Buse, Abhishek Gautam, Unsia Hussain, Victoria Olarewaju
Journal: BMJ (2023)

The dearth of disaggregated health data: a political rather than a technical challenge The failure to disaggregate population datasets hold back efforts to achieve health equity and to hold governments accountable for progress Kent Buse, 1 Abhishek Gautam, 2 Unsia Hussain, 3 Victoria Olarewaju 3 "We commit to leave no one behind and we commit, by 2020, to strengthen capacity to report disaggregated data."These were among promises made by governments when they agreed to the Sustainable Development Goals in 2015. 1 Covid-19 put both of those commitments to the test.It was clear from the outset of the pandemic that health outcomes were not evenly spread across the population: certain groups of people were more exposed to the virus, or experienced greater health impacts, or had less access to quality health services.Front line health workers and people who lacked the opportunity to work from home were more likely to become infected.Women were less likely to be admitted to intensive care compared to men who were admitted to hospital.The likelihood of death among people with pre-existing morbidities, older people, and men was higher compared to women or younger people. 2 As the pandemic wore on, further trends were revealed, including who had greater access to testing and vaccines.Although this was understood in broad terms, many country-specific realities were not systematically reported and published by governments-at least not initially.
In the US, patient data privacy is an illusion
Authors: Harlan M Krumholz
Journal: BMJ (2023)

In the US, patient data privacy is an illusionPatients can no longer share personal information about themselves and be confident it remains private Harlan M Krumholz professor of medicine One of the sacred tenets of medicine is that our conversations with our patients are private.Those of us who have the privilege of being physicians walk into rooms where we engage strangers in intimate conversations that reveal sensitive details of their lives.People may share information they would not tell their closest friends or family.To be worthy of that trust, we learn to honour the special bond between doctor and patient, vowing never to violate their confidence.
Autophagy-related proteins: Potential diagnostic and prognostic biomarkers of aging-related diseases
Authors: Caterina Miceli, Manuela Leri, Massimo Stefani, Monica Bucciantini
Journal: Ageing Research Reviews (2023)

Autophagy plays a key role in cellular, tissue and organismal homeostasis and in the production of the energy load needed at critical times during development and in response to nutrient shortage. Autophagy is generally considered as a pro-survival mechanism, although its deregulation has been linked to non-apoptotic cell death. Autophagy efficiency declines with age, thus contributing to many different pathophysiological conditions, such as cancer, cardiomyopathy, diabetes, liver disease, autoimmune diseases, infections, and neurodegeneration. Accordingly, it has been proposed that the maintenance of a proper autophagic activity contributes to the extension of the lifespan in different organisms. A better understanding of the interplay between autophagy and risk of age-related pathologies is important to propose nutritional and life-style habits favouring disease prevention as well as possible clinical applications aimed at promoting long-term health.
Blood phytosterols in relation to cardiovascular diseases and mediating effects of blood lipids and hematological traits: a Mendelian randomization analysis
Authors: Yimin Zhao, Zhenhuang Zhuang, Yueying Li, Wendi Xiao, Zimin Song, Ninghao Huang, Wenxiu Wang, Xue Dong, Jinzhu Jia, Tao Huang
Journal: Metabolism (2023)
National and State-Level Trends in Nontraumatic Lower-Extremity Amputation Among U.S. Medicare Beneficiaries With Diabetes, 2000–2017
Authors: Jessica L. Harding, Linda J. Andes, Deborah B. Rolka, Giuseppina Imperatore, Edward W. Gregg, Yanfeng Li, Ann Albright
Journal: Diabetes Care (2020)

OBJECTIVE Diabetes is a leading cause of nontraumatic lower-extremity amputation (NLEA) in the U.S. After a period of decline, some national U.S. data have shown that diabetes-related NLEAs have recently increased, particularly among young and middle-aged adults. However, the trend for older adults is less clear. RESEARCH DESIGN AND METHODS To examine NLEA trends among older adults with diabetes (≥67 years), we used 100% Medicare claims for beneficiaries enrolled in Parts A and B, also known as fee for service (FFS). NLEA was defined as the highest-level amputation per patient per calendar year. Annual NLEA rates were estimated from 2000 to 2017 and stratified by age-group, sex, race/ethnicity, NLEA level (toe, foot, below-the-knee amputation [BKA], or above-the-knee amputation [AKA]), and state. All rates were age and sex standardized to the 2000 Medicare population. Trends over time were assessed using Joinpoint regression and annual percent change (APC) reported. RESULTS NLEA rates (per 1,000 people with diabetes) decreased by half from 8.5 in 2000 to 4.4 in 2009 (APC −7.9, P &amp;lt; 0.001). However, from 2009 onward, NLEA rates increased to 4.8 (APC 1.2, P &amp;lt; 0.01). Trends were similar across most age, sex, and race/ethnic groups, but absolute rates were highest in the oldest age-groups, Blacks, and men. By NLEA type, overall increases were driven by increases in rates of toe and foot NLEAs, while BKA and AKA continued to decline. The majority of U.S. states showed recent increases in NLEA, similar to national estimates. CONCLUSIONS This study of the U.S. Medicare FFS population shows that recent increases in diabetes-related NLEAs are also occurring in older populations but at a less severe rate than among younger adults (&amp;lt;65 years) in the general population. Preventive foot care has been shown to reduce rates of NLEA among adults with diabetes, and the findings of the study suggest that those with diabetes—across the age spectrum—could benefit from increased attention to this strategy.
Glymphatic influx and clearance are accelerated by neurovascular coupling
Authors: Stephanie Holstein-Rønsbo, Yiming Gan, Michael J. Giannetto, Martin Kaag Rasmussen, Björn Sigurdsson, Felix Ralf Michael Beinlich, Laura Rose, Verena Untiet, Lauren M. Hablitz, Douglas H. Kelley, Maiken Nedergaard
Journal: Nature Neuroscience (2023)
Augmenting hippocampal–prefrontal neuronal synchrony during sleep enhances memory consolidation in humans
Authors: Maya Geva-Sagiv, Emily A. Mankin, Dawn Eliashiv, Shdema Epstein, Natalie Cherry, Guldamla Kalender, Natalia Tchemodanov, Yuval Nir, Itzhak Fried
Journal: Nature Neuroscience (2023)

Memory consolidation during sleep is thought to depend on the coordinated interplay between cortical slow waves, thalamocortical sleep spindles and hippocampal ripples, but direct evidence is lacking. Here, we implemented real-time closed-loop deep brain stimulation in human prefrontal cortex during sleep and tested its effects on sleep electrophysiology and on overnight consolidation of declarative memory. Synchronizing the stimulation to the active phases of endogenous slow waves in the medial temporal lobe (MTL) enhanced sleep spindles, boosted locking of brain-wide neural spiking activity to MTL slow waves, and improved coupling between MTL ripples and thalamocortical oscillations. Furthermore, synchronized stimulation enhanced the accuracy of recognition memory. By contrast, identical stimulation without this precise time-locking was not associated with, and sometimes even degraded, these electrophysiological and behavioral effects. Notably, individual changes in memory accuracy were highly correlated with electrophysiological effects. Our results indicate that hippocampo-thalamocortical synchronization during sleep causally supports human memory consolidation.
Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer’s disease
Authors: Na Sun, Leyla Anne Akay, Mitchell H. Murdock, Yongjin Park, Fabiola Galiana-Melendez, Adele Bubnys, Kyriaki Galani, Hansruedi Mathys, Xueqiao Jiang, Ayesha P. Ng, David A. Bennett, Li-Huei Tsai, Manolis Kellis
Journal: Nature Neuroscience (2023)
β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice
Authors: Yini Zhao, Qiuyang Zheng, Yujuan Hong, Yue Gao, Jiaojiao Hu, Maoju Lang, Hongfeng Zhang, Ying Zhou, Hong Luo, Xian Zhang, Hao Sun, Xiao-Xin Yan, Timothy Y. Huang, Yan-Jiang Wang, Huaxi Xu, Cong Liu, Xin Wang
Journal: Nature Neuroscience (2023)
Genomic profiling informs diagnoses and treatment in vascular anomalies
Authors: Dong Li, Sarah E. Sheppard, Michael E. March, Mark R. Battig, Lea F. Surrey, Abhay S. Srinivasan, Leticia S. Matsuoka, Lifeng Tian, Fengxiang Wang, Christoph Seiler, Jill Dayneka, Alexandra J. Borst, Mary C. Matos, Scott M. Paulissen, Ganesh Krishnamurthy, Bede Nriagu, Tamjeed Sikder, Melissa Casey, Lydia Williams, Sneha Rangu, Nora O’Connor, Alexandria Thomas, Erin Pinto, Cuiping Hou, Kenny Nguyen, Renata Pellegrino da Silva, Samar N. Chehimi, Charlly Kao, Lauren Biroc, Allison D. Britt, Maria Queenan, Janet R. Reid, Joseph A. Napoli, David M. Low, Seth Vatsky, James Treat, Christopher L. Smith, Anne Marie Cahill, Kristen M. Snyder, Denise M. Adams, Yoav Dori, Hakon Hakonarson
Journal: Nature Medicine (2023)
The role of m6A methylation in therapy resistance in cancer
Authors: Hengzhao Zhuang, Bo Yu, Dan Tao, Xiaoyan Xu, Yijun Xu, Jian Wang, Yang Jiao, Lili Wang
Journal: Molecular Cancer (2023)

Cancer therapy resistance is the main cause of cancer treatment failure. The mechanism of therapy resistance is a hot topic in epigenetics. As one of the most common RNA modifications, N6-methyladenosine (m6A) is involved in various processes of RNA metabolism, such as stability, splicing, transcription, translation, and degradation. A large number of studies have shown that m6A RNA methylation regulates the proliferation and invasion of cancer cells, but the role of m6A in cancer therapy resistance is unclear. In this review, we summarized the research progress related to the role of m6A in regulating therapy resistance in cancers.
4CMenB sustained vaccine effectiveness against invasive meningococcal B disease and gonorrhoea at three years post programme implementation
Authors: Bing Wang, Lynne Giles, Prabha Andraweera, Mark McMillan, Sara Almond, Rebecca Beazley, Janine Mitchell, Michele Ahoure, Emma Denehy, Louise Flood, Helen Marshall
Journal: Journal of Infection (2023)
Dermatology in the wake of an AI revolution: Who gets a say?
Authors: Eric J. Beltrami, Jane M. Grant-Kels
Journal: Journal of the American Academy of Dermatology (2023)

To the Editor: We thank Ferreira and Lipoff for their response, which expands on salient ethical implications of artificial intelligence (AI) generated diagnoses in dermatology. Their insightful discussion raises additional ethical questions regarding patient autonomy, informed consent, and legal accountability as we look to a future in which AI and medicine coalesce.
Selected Articles from This Issue
Journal: Clinical Cancer Research (2023)

Highlights| June 01 2023 Selected Articles from This Issue Author & Article Information Online ISSN: 1557-3265 Print ISSN: 1078-0432 ©2023 American Association for Cancer Research2023American Association for Cancer Research Clin Cancer Res (2023) 29 (11): 2013. https://doi.org/10.1158/1078-0432.CCR-29-11-HI Related Content A commentary has been published: Multicenter Phase I Trial of Ivosidenib as Maintenance Treatment Following Allogeneic Hematopoietic Cell Transplantation for IDH1-Mutated Acute Myeloid Leukemia A commentary has been published: A Phase II Study of Epacadostat and Pembrolizumab in Patients with Advanced Sarcoma A commentary has been published: A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy View more A commentary has been published: A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer View less Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record June 1 2023 Citation Selected Articles from This Issue. Clin Cancer Res 1 June 2023; 29 (11): 2013. https://doi.org/10.1158/1078-0432.CCR-29-11-HI Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Outcomes for acute myeloid leukemia (AML) remain suboptimal. The curative approach is hematopoietic cell transplantation (HCT) for most patients, although subsequent relapse is common. IDH inhibitors have revealed tolerability and activity in relapsed/refractory patients and have been approved for use. Despite this, maintenance therapy with the IDH1 inhibitor ivosidenib has not been adequately studied. In this phase I study, Fathi and colleagues evaluated ivosidenib as maintenance following HCT for AML and found the agent to be well tolerated. At the recommended phase II dose of 500 mg daily, progression-free and overall survival compared favorably to historical data. The authors also assessed IDH1 allelic burden prior to transplant and prior to maintenance, and, due to the small number of patients in this phase II study, could not conclude a definitive predictive trend for outcomes. The results from this trial have substantial value in promoting a rationale to pursue more advanced-phase, larger... You do not currently have access to this content.
Ketone ester supplementation suppresses cardiac inflammation and improves cardiac energetics in a swine model of acute myocardial infarction
Authors: Salva R. Yurista, Robert A. Eder, Aidan Welsh, William Jiang, Shi Chen, Anna N. Foster, Adam Mauskapf, W.H. Wilson Tang, William J. Hucker, Jaume Coll-Font, Anthony Rosenzweig, Christopher T. Nguyen
Journal: Metabolism (2023)
Feasibility and Outcomes of Temporary Bulbar Urethral Stent Placement After Internal Urethrotomy in the Largest Multicenter Series
Authors: Omid Sedigh, Ettore Dalmasso, Andrea Gobbo, Mohammad H. Dashti, Fariborz Bagheri, Ahmad Shamsodini, Yaqoub Alqattan, Farzin Soleimanzadeh, Nicolò Maria Buffi, Paolo Gontero, Jalil Hosseini
Journal: European Urology (2023)
Effect of real-time computer-aided detection of colorectal adenoma in routine colonoscopy (COLO-GENIUS): a single-centre randomised controlled trial
Authors: David Karsenti, Gaëlle Tharsis, Bastien Perrot, Philippe Cattan, Alice Percie du Sert, Franck Venezia, Elie Zrihen, Agnès Gillet, Jean-Philippe Lab, Gilles Tordjman, Maryan Cavicchi
Journal: The Lancet. Gastroenterology & hepatology (2023)
Table of Contents
Authors: Romy Neuner, Jinwoo Lee, Kerri Rieger, Caroline Park, Alexander Colevas, Anne Lynn, S Chang, Lisa Zaba, Bernice Kwong, Dirk Elston, Brett Sloan, Jonathan Kantor, Warren Heymann, Alexa Bowie, Mina Tadrous, Deva Thiruchelvam, Noah Ivers, Tanya Mohan, Karen Tu, Liisa Jaakkimainen, Aaron Drucker
Journal: Journal of the American Academy of Dermatology (2023)
JAAD Case Reports Article List
Authors: Aubriana Mcevoy, Jeremy Light, Aaron Russell, Muithi Mwanthi, Jack Newcomer, Hesham Alshaikh, Katie Lynam, Laura Winterfield, Patricia Zhao, Mary-Margaret Noland, Darren Guffey, Raji Nagalla, Bonnie Lee, Janellen Smith, Christina Kraus, Warty Lesions, Giulia Rinaldi, Pauline Marren, Christopher Bunker, Deirdre O'callaghan, Jamie Garrett, Ata Moshiri, Anna Cogen, Elise Burger, Brian Hinds, Taraneh Paravar, Yun Jee, Ji Doh, Ricardo Torres-Delgadillo, Eduardo Corona-Rodarte, Larissa Navarro-Soberanes, Mariana Larios-Ca ´rdenas, Georgina Sierra-Silva, Grace Hingtgen, Rafael Mojica, Kiran Motaparthi, Luis Iv Santaliz-Ruiz, Fabiola Pabo ´n-Gonza ´lez, Francisco Colo ´n-Fonta ´nez, Thinh Chau, Joseph Wu, Benjamin Kahn, Christopher Elco, M Marinkovich, Kerri Rieger, Leslie Robinson-Bostom, Elnaz Firoz, Kristin Slater, Brittany Valk, Francisca Kartono, Sophie Gue ´nin, Saakshi Khattri, Mark Lebwohl, David Petrosian, Paloma Do, Sirota Reiter, Sergey Rozenberg, Hayato Mizuno, Shunsuke Takahagi, Daiki Matsubara, Takanobu Kan, Keiichi Mori, Koji Arihiro, Akio Tanaka, Justin Raman, Annie Jin, Jennifer Parker, M Vickers, Daniela Proca, Sylvia Hsu, Jason Lee, Areeba Abid, Douglas Parker, Travis Blalock, Annika Belzer, Madisen Swallow, Michael Gowen, Kathleen Suozzi, Mohammed Alfada, Ahmed Alhumidi, Tariq Alhogbani, Aya Al Rawahi, Buthaina Al Musalhi, Reem Abdwani, Claire Alexanian, Carl Schanbacher, Manish Gharia, Alana Deutsch, Natalia Rodriguez, Simon Roy, Jonathan Leventhal, Ramneek Dhami, Nasro Isaq, Megha Tollefson, Oluwaseun Oyeku, Drew Mitchell, Hillary Elwood, John Durkin, Emma Villamaria, Chelsea Steele, Megan Rogge, Saud Binsufayan, Israel Kasago, Garett Grant, Dev Sahni, Abigail Florell, Christopher Hull, Scott Florell, Rodney Miles, David Wada, Anneli Bowen, Valeria Torres-Guillen, Kevin Teran-De-La-Sancha, Alejandro Barrera-Godı ´nez, Michelle Gatica-Torres, Mandour Mandour, Safa Al-Musawi, Esther Idowu, Paul Long, Ellie Rashidghamat, Jude Oben, Jan Homolak, Elena Pastukhova, Feras Ghazawi
Journal: Journal of the American Academy of Dermatology (2023)
Heparin for women with recurrent miscarriage and inherited thrombophilia (ALIFE2): an international open-label, randomised controlled trial
Authors: Siobhan Quenby, Katie Booth, Louise Hiller, Arri Coomarasamy, Paulien G de Jong, Eva N Hamulyák, Luuk J Scheres, Thijs F van Haaps, Lauren Ewington, Shreeya Tewary, Mariëtte Goddijn, Saskia Middeldorp
Journal: The Lancet (2023)
Association of dysanapsis with mortality among older adults
Authors: Motahareh Vameghestahbanati, Coralynn Sack, Artur Wysoczanski, Eric A. Hoffman, Elsa Angelini, Norrina B. Allen, Alain G. Bertoni, Junfeng Guo, David R. Jacobs, Joel D. Kaufman, Andrew Laine, Ching-Long Lin, Daniel Malinsky, Erin D. Michos, Elizabeth C. Oelsner, Steven J. Shea, Karol E. Watson, Andrea Benedetti, R. Graham Barr, Benjamin M. Smith
Journal: European Respiratory Journal (2023)

<b>Dysanapsis – an anthropometric mismatch between airway tree calibre and lung size that is common in the general population – is strongly associated with all-cause mortality and increases susceptibility to tobacco smoking-related diseases</b> https://bit.ly/42oDe8J
The effect of beclomethasone–formoterol<i>versus</i>placebo on chronic cough in patients with non-CF bronchiectasis: the FORZA randomised controlled trial
Authors: Tjeerd van der Veer, Johanna Margaretha de Koning Gans, Gerrit J. Braunstahl, Angelina L.P. Pieters, Johanna M.W. van den Berg, Rogier A.S. Hoek, Lieke S.J. Kamphuis, Marleen Bakker, Alain V.F. Dubois, Joachim G.J.V. Aerts, Menno M. van der Eerden
Journal: European Respiratory Journal (2023)

<h3>Tweetable abstract</h3> <b>The FORZA trial investigated beclomethasone–formoterol <i>versus</i> placebo in bronchiectasis without asthma or COPD. There were no signs of benefit and more adverse events, which warrants caution for the prescription of ICS/LABA therapy in bronchiectasis.</b>https://bit.ly/3BMMUhX
Tom Nolan’s research reviews—1 June 2023
Authors: Tom Nolan
Journal: BMJ (2023)

Scanning for pulmonary embolismWe all know that feeling when a colleague comes up to you with a grave look on their face and says, "You remember that patient you saw last week with…."On a good day the story might go that you admitted the patient to hospital, it turns out that they had a pulmonary embolism, and now they're better.And on a bad day?Well, you'd better hope you made some good notes and, better still, followed a validated pulmonary embolism clinical decision rule.These are intended to answer the age-old question: "How do you know it isn't a pulmonary embolism?"without always having to request a computed tomography pulmonary angiogram (CTPA).But CTPA testing seems to be going up regardless.A retrospective analysis of 26 emergency departments in six European countries found that, between 2015 and 2019, the rate of CTPA testing increased from 836 per 100 000 emergency department visits to 1112 per 100 000.The rate of diagnosis of pulmonary embolism went up too, but, as diagnosis went up, so did the proportion of low risk pulmonary embolisms, while the proportion requiring intensive care went down.
Good health for its own sake
Authors: Tom Moberly
Journal: BMJ (2023)

Good health for its own sake Tom Moberly UK editorFor too long, societies around the world have tended to see money that is spent on healthcare as simply a cost to be borne, while considering spending on innovation, infrastructure, or education to be investments.But if you don't see health as an investment, then you do not consider the importance of health when formulating policy, particularly economic policy.