tbuckley/cabot-search huggingface dataset:
Inhibition by Tuftsin of Rauscher Virus Leukemia Development in Mice&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Ahuva Knyszynski, Philip Gottlieb, Mati Fridkin
Journal: JNCI Journal of the National Cancer Institute (1983)

The antitumor effect of tuftsin, the natural phagocytosis-stimulating peptide, on leukemia induced by Rauscher murine leukemia virus (R-MuLV) was studied in vivo in SWR inbred mice. Tuftsin was found capable of significantly increasing the survival of R-MuLV-infected mice. The peptide, when injected both ip and iv into mice, exerted its activity in a dose- and time-dependent manner. Optimal antitumor activity was achieved upon administration of 25 μg tuftsin 4 days before R-MuLV inoculation.
Comparison of Ammonium Alum and Tannic Acid as Barium Enema Additives
Authors: George M. Wyatt
Journal: JAMA (1966)

This is a preliminary report on ammonium alum as a substitute for the tannic acid formerly used in barium sulfate enemas to promote colon contraction and barium coating of the colon mucosa. The "mucosal pattern" thus produced on postevacuation films is useful in tumor diagnosis because a tumor larger than the contracted lumen produces a bulge or distortion of this pattern. Experimental and clinical studies indicate that alum is equal to tannic acid in every respect except that it does not maintain colon contraction quite as long. Either additive is far better than none. Alum was not toxic in the amounts found effective.
Ten Weeks with Chinese Bandits.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antihypertensives and the Risk of Serious Hypoglycemia in Older Persons Using Insulin or Sulfonylureas
Authors: Ronald I. Shorr
Journal: JAMA (1997)

<h3>Context.</h3> —β-Blockers and angiotensin-converting enzyme (ACE) inhibitors are effective antihypertensive agents for patients with diabetes mellitus. However, β-blockers attenuate some components of the autonomic response to hypoglycemia and could increase the risk of hypoglycemia. ACE inhibitors may increase insulin sensitivity and predispose users to hypoglycemia. <h3>Objective.</h3> —To determine whether use of cardioselective β-blockers, nonselective β-blockers, ACE inhibitors, thiazide diuretics, calcium channel blockers, or other antihypertensive drugs alters the risk of developing serious hypoglycemia among older persons prescribed insulin or sulfonylureas. <h3>Design.</h3> —Retrospective cohort study. <h3>Setting.</h3> —Tennessee Medicaid Program. <h3>Patients.</h3> —A total of 13 559 elderly (mean age, 78±7 years) Medicaid enrollees, who were prescribed insulin (n=5171, 38%) or sulfonylureas (n=8368, 62%) from 1985 through 1989. These enrollees contributed a total of 33107 person-years of insulin or sulfonylurea use for follow-up. <h3>Measurements.</h3> —Hospitalization, emergency department admission, or death associated with hypoglycemic symptoms and a concomitant blood glucose determination of less than 2.8 mmol/L (50 mg/dL). <h3>Results.</h3> —We identified 598 persons with an episode of serious hypoglycemia during the study period. The rate of serious hypoglycemia was 2.01 per 100 person-years among those who were not prescribed antihypertensives. Crude rates of serious hypoglycemia were highest among users of ACE inhibitors (2.47 per 100 person-years) and lowest among users of cardioselective β-blockers (1.23 per 100 person-years). However, when we controlled for demographic characteristics and markers of comorbidity, there was no statistically significant increase or decrease in risk of serious hypoglycemia among users of any class of antihypertensive agents compared with nonusers of antihypertensive drugs. Using nonselective β-blockers as the reference group, each of these agents was associated with a lower, but not statistically significant, risk of hypoglycemia. <h3>Conclusions.</h3> —In this population, specific antihypertensive drug therapy had little impact on the risk of hypoglycemia in older diabetic patients. Therapy should be chosen based on other considerations of safety and effectiveness.
Pharmacology and Therapeutics for Students and Practitioners of Medicine.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sulfanilamide and Related Compounds in General Practice
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acknowledgment to reviewers
Authors: N Abdou, W Abraham, A Adinoff, N Adkinson, K Adler, L Altman, S Anderson, J Anderson, L Arlian, P Askenase, F Mcd, M Atkins, H Bach, S Baer, B Bahna, M Baldo, E Ballow, P Bardana, K Barnes, R Barrett, R Bascorn, M Benyon, I Berger, D Bernstein, L Bernstein, B Bielory, J Bjorksten, M Black, S Blumenthal, S Bock, L Bonini, H Boulet, J Boushey, P Bousquet, R Braquet, I Brenner, S Broder, R Brooks, C Buckley, A Buckley, B Burks, R Burrcws, W Bush, B Busse, M Butcher, A Capron, T Cartier, C Casale, H Casterline, N Chai, M Chand, K Chapman, M Chung, D Church, M Cockcroft, C Cohen, R Collins, J Colman, M Condemi, M Conley, M Conolly, B Conroy, T Corrin, G Cromwell, C Cropp, B Cunningham-Rundles, R Czametzki, J Davies, R Denburg, C Deshazo, J Dinarello, S Dolovich, J Douglas, D Douglas, J Downing, S Drazen, H Dreborg, S Druce, P Durham, P Edelstein, R Eggleston, G Einarsson, P Eisenbarth
Journal: Journal of Allergy and Clinical Immunology (1989)
Acute Septicemic Melioidosis
Authors: Jack E. Zimmerman
Journal: JAMA (1970)

<i>The acute septicemic form of melioidosis is associated with a high mortality despite currently recommended antibiotic therapy. A patient who developed multiple complications of wounds received in Vietnam, including</i>Pseudomonas pseudomallei<i>septicemia, was successfully treated with gentamicin sulfate. The use of this drug in the treatment of melioidosis has not been previously reported. Gentamicin may be useful in the treatment of this disease.</i>
A Community for Emergency Program Cardiac Care
Authors: Walter S. Graf
Journal: JAMA (1973)

Of 1,240 transported patients, 70% were hospitalized. Forty-four percent of the hospitalized patients had acute myocardial infarction and of this group, 32% had a serious or life-threatening arrhythmia prior to hospitalization. There were 35 long-term resuscitations. Patients were treated by fire department paramedics in about the same manner as those treated by coronary care unit nurses and with similar results. Skilled personnel using an ordinary ambulance performed as well as those using the elaborate coronary ambulance. An intensive local publicity program markedly increased the utilization of the program without any increase in unjustified calls. The average call-for-help time was about one half as long when the fire rescue paramedic was called rather than when a physician was called.
Δ9-Tetrahydrocannabinol for Refractory Vomiting Induced by Cancer Chemotherapy
Authors: Virgil S Lucas
Journal: JAMA (1980)

Fifty-three patients receiving antineoplastic chemotherapy who had experienced severe nausea and vomiting refractory to standard antiemetic agents were treated with Δ<sup>9</sup>-tetrahydrocannabinol (THC). These patients were given THC 8 to 12 hours before, during, and for 24 hours after chemotherapy. Ten patients (19%) had no further nausea and vomiting; 28 (53%) had at least a 50% reduction of nausea and vomiting compared to previous courses with the same agents. No appreciable reduction of nausea and vomiting was seen in 15 patients (28%). Toxic reactions were generally mild, with only four patients experiencing reactions that necessitated stopping THC therapy. We suggest that, since THC is a useful antiemetic agent in patients having refractory chemotherapy-induced vomiting, existing restrictions prohibiting its therapeutic use should promptly be eased. (<i>JAMA</i>243:1241-1243, 1980)
Atopic dermatitis, STAT3- and DOCK8-hyper-IgE syndromes differ in IgE-based sensitization pattern
Authors: A. C. Boos, B. Hagl, A. Schlesinger, B. E. Halm, N. Ballenberger, M. Pinarci, V. Heinz, D. Kreilinger, B. D. Spielberger, L. F. Schimke-Marques, J. Sawalle-Belohradsky, B. H. Belohradsky, B. Przybilla, B. Schaub, A. Wollenberg, E. D. Renner
Journal: Allergy (2014)

Background Increased serum IgE levels are characteristic but not specific for allergic diseases. Particularly, severe atopic dermatitis (AD) overlaps with hyper-IgE syndromes (HIES) regarding eczema, eosinophilia, and increased serum IgE levels. HIES are primary immunodeficiencies due to monogenetic defects such as in the genes DOCK8 and STAT3. As it is not known to date why allergic manifestations are not present in all HIES entities, we assessed the specificity of serum IgE of AD and HIES patients in the context of clinical and immunological findings. Methods Clinical data, skin prick tests, specific IgE to aero- and food allergens, and T helper (Th) subpopulations were compared in AD and molecularly defined HIES patients. Results Total serum IgE levels were similarly increased in STAT3-HIES, DOCK8-HIES, and AD patients. The ratio of aeroallergen-specific IgE to total IgE was highest in AD, whereas DOCK8-HIES patients showed the highest specific serum IgE against food allergens. Overall, clinical allergy and skin prick test results complied with the specific IgE results. Th2-cell numbers were significantly increased in DOCK8-HIES and AD patients compared to STAT3-HIES patients and controls. AD patients showed significantly higher nTreg-cell counts compared to STAT3-HIES and control individuals. High Th17-cell counts were associated with asthma. Specific IgE values, skin prick test, and T-cell subsets of STAT3-HIES patients were comparable with those of healthy individuals except decreased Th17-cell counts. Conclusion Hyper-IgE syndromes and atopic dermatitis patients showed different sensitization pattern of serum IgE corresponding to the allergic disease manifestations and Th-cell subset data, suggesting a key role of DOCK8 in the development of food allergy.
Late Appearance of Postpartum Eclampsia
Authors: J. Michaeli
Journal: JAMA (1985)

<h3>To the Editor.—</h3> Postpartum eclampsia is uncommon. When it occurs it usually does so within 12 hours after delivery.<sup>1</sup>Occurrence during the first five days following delivery is exceedingly rare.<sup>1</sup>Eclampsia occurring six days after delivery is so rare that the diagnosis can only be entertained after all other causes of convulsive disorders have been unequivocally excluded. I wish to report an unusual case of late postpartum eclampsia appearing seven days after delivery. <h3>Report of a Case.—</h3> A 26-year-old woman at term was admitted to the delivery room, complaining of severe headache and nausea. Two previous pregnancies and her present pregnancy had been uneventful. Her blood pressure was 140/95 mm Hg, and there was +1 ankle edema. Neurological examination findings were normal. While in labor, she became confused and her blood pressure rose to 170/100 mm Hg. She was treated with 5 mg of diazepam intravenously, 10 g
In memoriam of Jordi Mancebo
Authors: R. Moreno, J.C. Winck, F. Rua
Journal: Pulmonology (2022)

A prolific researcher, author, and teacher, he was responsible for teaching many of us in his preferred fields of respiratory failure, mechanical ventilation and ventilator weaning.Deeply involved with other Scientific Societies, such as the European Society of Intensive Care Medicine and the Pan-American and Iberian Federation of Intensive and Critical Care medicine, Jordi was also a close friend of the Portuguese Society of Intensive Care Medicine, both directly and indirectly, either as a frequent speaker or teacher at our events or in receiving many of us in his department to learn.From the late 90s he was deeply involved in the Mediterranean meetings on Non-Invasive Ventilation (NIV) which were organized in Italy, Spain, Portugal and France.In this forum both intensivists and pulmonologists from each county joined forces to discuss, on a yearly basis, the state of the art of NIV, of which Jordi was a great enthusiast and pioneer.Kind, modest, "friend of his friend", highly intelligent, his qualities made him the role-model for many young (and notso-young) intensivists.A standard too high for many of us.Now, though he is no longer physically among us, I am sure that he will be always be alive in our memories, and he will often be with us when we are faced with difficult patients.Fins sempre, Jordi.
Acid, burns, and feeding tubes
Authors: C M Danbury
Journal: BMJ (2002)

Are trust doctors the new lost tribe?Editor-The number of trust doctors (doctors in non-training grades) in the United Kingdom is rising as trusts try to meet both service and hours requirements and are unable to employ more doctors in training.The Department of Health has no code for trust doctors so its annual census cannot show how many there are.We surveyed the human resource departments in each acute trust in Yorkshire by postal questionnaire; nine out of 10 replied.We found that the number of trust doctor posts has increased at least fivefold over the past four years, and the current number will more than double in the near future on the basis of trusts' stated plans (figure).We sent separate questionnaires to 63 of a sample of 81 trust doctors in the region; 36 (57%) replied.They were asked questions about educational provision and supervision, reasons for being in the post, previous clinical experience, career aspirations, work patterns, and pay.With regard to education and training, 16 trust doctors reported that they had an educational supervisor and only six had appraisals.Although 32 trust doctors had been granted study leave, only 25 received funding for this.Surprisingly, 15 trust doctors rated their work as equivalent to that of a senior house officer and 21 as equivalent to a specialist registrar.Most of the doctors were United Kingdom graduates ( 16), with eight being from the Indian subcontinent, five from Africa and the Middle East, and one from the European Economic Area.The most common career aim was a consultant post in the United Kingdom (21 doctors), and the main reasons for taking a post as a trust doctor were as a "stop gap" or to gain
Researchers Dissect the Tick and Tock of the Human Body's Master Clock
Authors: Lynne Lamberg
Journal: JAMA (1997)

KNOWLEDGE about the body's biological clock may help both those who can't sleep and those who can't stay awake. It may permit travelers to avoid jet lag, improve workplace productivity, and reduce industrial and traffic mishaps caused by dips in alertness in the early morning hours. Clock research also may enable physicians to improve patient care by adding a new dimension—body time—to clinical decision making. Researchers recently reflected on what they know and where they're going. A 2-day symposium to mark the 25th anniversary of the discovery that the biological clock resides in a pair of islands of neurons within the hypothalamus, collectively called the suprachiasmatic nucleus (SCN) for its location just above the optic junction, drew 150 scientists and students to Harvard Medical School in August. Some 19 authors of key SCN papers agreed to discuss their work and recent advances in the field—every one of those invited to
The aftermath of the Bristol case
Authors: J. A R Willis, B. McKinstry, P J Tomlin, R. Dawson, A. J Gray, R. Hole, J. Egan, D. Lee, P. Fisher, R. J Geller, K. Gardiner, P. J Pemberton, J. Ramsay, D. Briley, R. Nicholson, A. K Banerjee, B. Webb, N Gainsborough, S. Kerrison, R H Lloyd-Mostyn, M. Ashley-Miller, G. J Elwyn, M. Lewis
Journal: BMJ (1998)
Fracture of Menghini Needle In Liver Biopsy
Authors: Robert S. Peters
Journal: JAMA (1968)

<h3>To the Editor:</h3> Despite general warnings to the contrary, the liver biopsy is frequently done by those not specifically trained in the technique. This report describes a case in which a replacement obturator for the Menghini liver-biopsy needle was provided by the hospital Central Supply Section without knowledge of the physicians. The use of the replacement obturator by a relatively inexperienced operator resulted in the bending and fracture of the needle near the hub, leaving the distal portion of the metal in the abdominal wall of the patient. <h3>Report of a Case:—</h3> A 70-year old divorced white man in May 1965 complained of pain in the right upper quadrant of six weeks' duration and fever of approximately ten days' duration, after rib fractures which healed spontaneously. The pain was intermittent, unassociated with food intake and was made worse by lying on the right side or the abdomen. The patient had
Update: Influenza Activity— United States, 1996-97 Season
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ethical Aspects of Human Experimentation in Health Services Research
Authors: Allan Brett
Journal: JAMA (1991)

OVER the past several decades, ethical issues in human experimentation have received increasing attention in the medical literature. Most of this literature presumes a fairly standard conception of modern medical research, ie, the application of a therapeutic intervention to a group of persons with a specific diagnosis. Prototypic examples include comparisons of two drugs, or drug and placebo, for specific diagnostic entities such as cancer. For lack of better terminology, we will refer to these studies collectively as<i>conventional research</i>. In contrast, the organizational, procedural, and economic aspects of health care provision have themselves become the focus of an enlarging body of research, termed<i>health services research</i>. Until recently, these studies were characterized primarily by either retrospective data collection or concurrent observation without experimental intervention. However, in an attempt to achieve greater scientific rigor, health services research has increasingly included prospective interventions involving human subjects. The scope of this research
A Diabetic Manual for the Mutual Use of Doctor and Patient
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal