tbuckley/cabot-search huggingface dataset:
Association of Breast Cancer and Cervical Cancer Incidences With Income and Education Among Whites and Blacks
Authors: Devesa, Susan S., Diamond, Earl L.
Journal: JNCI Journal of the National Cancer Institute (1980)

Journal Article Association of Breast Cancer and Cervical Cancer Incidences With Income and Education Among Whites and Blacks Get access Susan S. Devesa, Ph.D., Susan S. Devesa, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Earl L. Diamond, Ph.D. Earl L. Diamond, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 65, Issue 3, September 1980, Pages 515–528, https://doi.org/10.1093/jnci/65.3.515 Published: 01 September 1980 Article history Received: 14 September 1979 Revision received: 25 March 1980 Accepted: 28 March 1980 Published: 01 September 1980
Cover story: Kitaj's "Heart attack".
Journal: BMJ (1993)

diversity and extent of the many schemes that make information on health more widely available to people in developing countries.We hope that organisations and individuals who know about the subject will write and tell use more.In the near future the BMJ hopes to make itself more accessible to doctors and researchers overseas who cannot afford the normal subscriptions.As a first step the BMJ is organising a conference to bring together publishers, donors, and recipients of infor- mation on medicine and science to increase under- standing and cooperation.Details ofthe conference are not yet finalised, but anyone who is interested in participating or attending should contact the editor, Richard Smith.
False-positive HIV Test: Implications for the Patient
Authors: James F. Sullivan
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Of the first 15 persons referred to our center for a therapeutic recombinant gp120 vaccine trial, two were in fact not infected with the human immunodeficiency virus (HIV). Undocumented patient reports of a positive test for HIV infection must be confirmed prior to therapeutic interventions, especially if patients lack clinical manifestations of HIV disease. <h3>Report of Cases.—Case 1.</h3> —A 35-year-old heterosexual man contracted genital herpes simplex following vaginal intercourse with a prostitute. Three weeks later, he was tested for HIV at an anonymous testing center and told he was positive. Despondent, he did not return for results of a repeat test. Over 3 years, he sold most of his possessions, avoided dating, abstained from intercourse, ceased seeking to advance his career, and significantly increased his use of ethanol. The patient had a CD4 cell count of 0.87×10<sup>9</sup>/L (869/μL) on two occasions. He declined
Symptomatic Therapy in Viral Illness
Authors: William R. Beisel
Journal: JAMA (1974)

The ability to perform sustained nonphysical work is diminished during acute infectious illnesses. In this study, anticipated decrements in work performance did not occur when volunteers with experimentally induced sandfly fever were given symptomatic therapy. The therapeutic regimen, which included aspirin and propoxyphene hydrochloride administered every four hours for two days, did not entirely relieve fever or the symptoms of illness. This regimen had no detectable effect on the work performance of other noninfected volunteers included in the study as therapy controls. (<i>JAMA</i>228:581-584, 1974)
Diagnosis of Organic Nervous Diseases.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer of the Urogenital Tract: Kidney
Authors: Philip Rubin
Journal: JAMA (1968)

Although the majority of patients with advanced and metastatic renal cancer die of their disease, there are some long-term survivors. The natural history of this disease is often characterized by unexplained remissions. Causality of renal cancer in experimental and clinical terms is a fascinating subject. The kidney has been shown to be a target organ for hormones and is considered to have endocrine functions of its own. The relationship between hormones and renal neoplasia will be presented in the definition of its pathogenesis and the therapeutic applications that follow. The attributing of successful regression of metastases from hypernephroma to a specific agent or maneuver demands careful review. With only a few exceptions, the practice of removing a primary cancer despite dissemination is rarely advocated in oncologic practice. The case for nephrectomy—palliative vs curative—must be examined and considered in terms of newer concepts in cancer immunology. Whereas a decade ago this
Progressive Medicine. A Quarterly Digest of Advances, Discoveries, and Improvements in the Medical and Surgical Sciences.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Profile of 314 Americans Graduating From Foreign Medical Schools
Authors: Henry R. Mason
Journal: JAMA (1969)

Some students rejected by US medical schools enter foreign medical institutions, but little is known about the quality of their training. Questionnaires were completed by 314 Americans who successfully finished their education in medical schools outside the United States and Canada and received a license to practice in America during 1963-1965. Ninety percent attended medical schools in Europe or Mexico. Forty-five percent earned their degrees after five years of study, while almost the same number took six or more years. Time taken for graduate studies, however, generally equalled that of their contemporaries from American medical schools. Sixty-four percent were board certified or qualified and one-half were engaged in private practice. Seventy-three percent of the group received a passing grade the first time they took the Educational Council for Foreign Medical Graduates (ECFMG) examination; almost all (91%) passed a state licensure test the first try.
Awards, Appointments, Announcements
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Awards, Appointments, Announcements Get access JNCI: Journal of the National Cancer Institute, Volume 85, Issue 12, 16 June 1993, Pages 948–950, https://doi.org/10.1093/jnci/85.12.948 Published: 16 June 1993
Pathologic Findings in Perforation of the Myocardium by a Permanent Endocardial Electrode
Authors: Roger F. Wheelis
Journal: JAMA (1969)

Pathologic findings resulted from perforation of the myocardium by a permanent pacing catheter electrode. The catheter had passed obliquely through the wall of the right ventricle and lay exposed within the pericardial sac. A fibrous sheath surrounded the length of the perforating tract. This tract remained patent when the catheter was withdrawn. The catheter within the superior vena cava and right atrium was encased in propagated thrombus in which bacteria were demonstrated.
PANDEMIC INFLUENZA AND PNEUMONIA IN A LARGE CIVIL HOSPITAL
Authors: JOHN W. NUZUM
Journal: JAMA (1918)

Following the reports of a rapidly spreading and highly fatal pandemic of influenza and pneumonia in the Eastern States, and while the epidemic of influenza was raging at the Great Lakes Naval Training Station, a severe outbreak of this disease appeared among the civil population of Chicago.During the past five weeks, from September 23 to October 29, more than 2,000 patients were admitted to the wards of Cook County Hospital.Of these, 642 died, a mortality of 31 per cent.In the accompanying chart, of the first 500 deaths, it will be noted that the age period of highest mortality falls between 25 and 30 years.Among the total number of admissions during this period there were 122 soldiers, and thus far twenty\x=req-\ one cases have terminated fatally\p=m-\a mortality of 16 per cent.So far as the admissions to a large charity institution, such as the Cook County Hospital, may be regarded as an in- dex to the prevalence of the recent epidemic in Chicago, it appears that the disease is now defi- nitely on the decline.Ac- cordingly, it seems pertinent to report the results of an intensive study con- ducted during the past five weeks in the morgue and the laboratory of the Cook County Hospital. CLINICAL PICTUREThe incubation period varied from a few hours to one or two days.Short- ly after the arrival of the first fifty soldiers, five of Age period of highest mortality in the first 500 deaths.The ordinates represent the ages in five year periods, the abscissas the total number of deaths per period.It will be noted that the period of highest mortality is between 25 and 30 years.the nurses in attendance on these patients became violently ill, and during the following two weeks more than fifty nurses and twelve of the resident physicians contracted the disease.Three of the nurses died.Blood cultures, nasopharyngeal and tonsil swabs and cultures of the washed bronchial secretion were immediately taken by the laboratory staff, and four of the laboratory assistants were suddenly taken ill within the next forty-eight hours.The onset is sudden, with complaint of severe head- ache, dull, aching pains in the muscles and joints, general weakness and quite commonly dull pains in the lumbar region.Conjunctivitis is not infrequent in the initial stages.Sore throat is unusual.The patient takes to bed with chilly sensations, and the fever rises rapidly from 101 to 104 F. Early prostration is the rule.Epistaxis occurs in a considerable number of patients, in one person as much as a pint of bright red blood gushing from the nostrils.The pulse is accelerated and the respirations vary from 20 to 36 a minute.The second to the fourth day marks the From the Laboratory of Pathology of the Cook County Hospital.
WNT-modulating gene silencers as a gene therapy for osteoporosis, bone fracture, and critical-sized bone defects
Authors: Won-Taek Oh, Yeon-Suk Yang, Jun Xie, Hong Ma, Jung-Min Kim, Kwang-Hwan Park, Daniel S. Oh, Kyung-Hyun Park-Min, Matthew B. Greenblatt, Guangping Gao, Jae-Hyuck Shim
Journal: Molecular Therapy (2022)

Treating osteoporosis and associated bone fractures remains challenging for drug development in part due to potential off-target side effects and the requirement for long-term treatment. Here, we identify recombinant adeno-associated virus (rAAV)-mediated gene therapy as a complementary approach to existing osteoporosis therapies, offering long-lasting targeting of multiple targets and/or previously undruggable intracellular non-enzymatic targets. Treatment with a bone-targeted rAAV carrying artificial microRNAs (miRNAs) silenced the expression of WNT antagonists, schnurri-3 (SHN3), and sclerostin (SOST), and enhanced WNT/β-catenin signaling, osteoblast function, and bone formation. A single systemic administration of rAAVs effectively reversed bone loss in both postmenopausal and senile osteoporosis. Moreover, the healing of bone fracture and critical-sized bone defects was also markedly improved by systemic injection or transplantation of AAV-bound allograft bone to the osteotomy sites. Collectively, our data demonstrate the clinical potential of bone-specific gene silencers to treat skeletal disorders of low bone mass and impaired fracture repair. Treating osteoporosis and associated bone fractures remains challenging for drug development in part due to potential off-target side effects and the requirement for long-term treatment. Here, we identify recombinant adeno-associated virus (rAAV)-mediated gene therapy as a complementary approach to existing osteoporosis therapies, offering long-lasting targeting of multiple targets and/or previously undruggable intracellular non-enzymatic targets. Treatment with a bone-targeted rAAV carrying artificial microRNAs (miRNAs) silenced the expression of WNT antagonists, schnurri-3 (SHN3), and sclerostin (SOST), and enhanced WNT/β-catenin signaling, osteoblast function, and bone formation. A single systemic administration of rAAVs effectively reversed bone loss in both postmenopausal and senile osteoporosis. Moreover, the healing of bone fracture and critical-sized bone defects was also markedly improved by systemic injection or transplantation of AAV-bound allograft bone to the osteotomy sites. Collectively, our data demonstrate the clinical potential of bone-specific gene silencers to treat skeletal disorders of low bone mass and impaired fracture repair.
The Spectrum and Impact of Metabolic Dysfunction in MAFLD: A Longitudinal Cohort Analysis of 32,683 Overweight and Obese Individuals
Authors: Kai En Chan, Cheng Han Ng, Clarissa Elysia Fu, Jingxuan Quek, Gwyneth Kong, Yi Jie Goh, Rebecca Wenling Zeng, Michael Tseng, Manik Aggarwal, Benjamin Nah, Douglas Chee, Zhen Yu Wong, Sitong Zhang, Jiong-Wei Wang, Nicholas W.S. Chew, Yock Young Dan, Mohammad Shadab Siddiqui, Mazen Noureddin, Arun J. Sanyal, Mark Muthiah
Journal: Clinical Gastroenterology and Hepatology (2022)
Evaluation of the Male Partner of an Infertile Couple
Authors: Ronald S. Swerdloff
Journal: JAMA (1982)

THE FIRST and most important rule in the evaluation of infertility is to consider the problem from the standpoint of both members of the couple. Too often a woman is extensively investigated only to discover later that her husband is azoospermic, and, likewise, a man undergoes lengthy treatment for oligospermia while his wife has undiagnosed tubal obstruction or has anovulatory cycles. The evaluation of both the man and woman should proceed in parallel until a significant problem is uncovered. Ideal management is attained in a clinical setting where the couple is seen by a team of physicians. In the usual case, where the man is under the care of either an endocrinologist or a urologist and the woman is under the care of a gynecologist, communication between physicians must be ongoing. The male partner should undergo a complete history and physical examination with special emphasis on the reproductive system. The
Human albumin administration in critically ill patients
Authors: A. Petros, M. Schindler, C. Pierce, S. Jacobe, Q. Mok, M. R Nel, S. Nadel, S. Marriage, C. De Munter, J. Britto, P. Habibi, M. Levin, M Kaag, F A N Zoetmulder, F A. I Riordan, A. Williams, A. P J Thomson, N. Soni, N. W Goodman, R J Beale, D L A Wyncoll, A McLuckie, J D Frame, N Moiemem, I. Chalmers, P G Lawler, G A Morgan, K H Shwe, M Bhavnani, I. Roberts
Journal: BMJ (1998)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Human albumin administration in critically ill patients Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
YELLOW FEVER AND ITS PREVENTION.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Studies on Inhibition of Viral Oncogenesis. I. Reduced Tumor Incidence in Hamsters Inoculated With Adenovirus 12 and Treated With Clam Extracts
Journal: JNCI Journal of the National Cancer Institute (1968)

Newborn hamsters were inoculated subcutaneously with adenovirus type 12, and 4–5 days later they were treated with a series of subcutaneous injections of extracts made from the shucked whole body of the hard clam, Mercenaria mercenaria, or from its liver (digestive diverticulum). Incidence of subsequent formation of solid subcutaneous tumors was then reduced from 71, 46, and 87% in the control hamsters to 24, 4, and 32% in the treated animals. This study extended the observations by other workers and us on the inhibition of oncogenesis due to adenovirus 12 in hamsters.
Private finance scheme for Worcester
Authors: B McCloskey
Journal: BMJ (2000)

Plan represents considerable privatisationEditor-Dixon and Dewar's editorial welcomes the considerable injection of money promised in the NHS plan and claims that the plan is true to the NHS's founding principles. 1 Yet Aneurin Bevan's greatest achievement, and not one demanded of him by the Beveridge report, was the nationalisation of hospitals.He recognised that ownership was important, because with ownership comes control.The NHS plan promises 100 new hospitals by 2010 (69 of which are already in the pipeline).This will involve £7bn of new investment under the private finance initiative.Together with the new plans for some NHS operating to be carried out in the private sector, the NHS plan represents a larger privatisation than even the Tories planned.Curiously, the plan also recognises the failure of past privatisations.I remember unsuccessfully voting against the privatisation of cleaning at the London Hospital when I was a board member of the old Tower Hamlets Health Authority.Squalid wards followed, and they remain with us now.The plan recognises that this policy was a disaster.Altogether £30m of cash is to be injected into hospital trusts before the next election to pay for the consequences of this mistaken minor privatisation.How much money will we have to spend in five, 10, or 20 years' time to correct the disastrous policy of major privatisation that we are now heading for?Mr Milburn, think again, before it is too late.
The Sensitivity and Specificity of Clinical Diagnostics During Five Decades
Authors: Robert E. Anderson
Journal: JAMA (1989)

Published studies encompassing more than 50 000 autopsies were assessed to determine the sensitivity and specificity of clinical diagnostics (the diagnostic process) in persons dying of 1 of 11 specific diseases during the period 1930 through 1977. The accuracy of clinical diagnostics, as reflected in these two determinations, appeared to improve over this period with respect to some of the diseases studied (rheumatic heart disease and leukemia), while for others it worsened (pulmonary tuberculosis, peritonitis, carcinoma of the lung, gastric carcinoma, and carcinoma of the liver and extrahepatic biliary tract) and for a significant number diagnostic accuracy seemed refractory to sustained change (pulmonary embolism, primary cirrhosis of the liver, gastric/peptic ulcer, and acute coronary thrombosis/myocardial infarction). The findings suggest a new way in which the autopsy can be used to monitor clinical diagnostics to identify possible sources of systematic weaknesses and provide data that can be used to approach the difficult subject of necessary fallibility. (<i>JAMA</i>. 1989;261:1610-1617)
Afferent Pupil Testing in Orbital-Facial Trauma
Authors: Terence G. Klingele
Journal: JAMA (1984)

<h3>To the Editor.—</h3> Facial trauma frequently results in soft-tissue injury with edema and/or hematoma formation, leading to closure of the eyelids within a short time. Under these circumstances, evaluation of the condition of the globe may be difficult, and an accurate test of visual acuity may be impossible. This is especially true if there is a disturbance of mental function associated with the trauma or intoxication. Even though it may be impossible to lift the upper lid enough to visualize the globe because of tense swelling or local tenderness, one may evaluate the function of the optic nerve and retina by flashing a bright penlight onto the closed eyelids in a darkened room, observing the reaction of the opposite pupil. In a mirror, the clinician can demonstrate this on himself or herself by observing the reaction of the left pupil to a bright light flashed onto the closed right eyelid.
DIAGNOSIS OF GALLBLADDER DISEASE
Authors: William Fitch Cheney
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal