tbuckley/cabot-search huggingface dataset:
SURGERY.
Journal: JAMA (1883)

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Unreviewed Reports
Authors: M Moosa, T Lazarou
Journal: BMJ (1984)

Unreviewed ReportsRetroperitoneal fibrosis presenting with isolated renal artery stenosis Renal artery stenosis due to retroperitoneal fibrosis has been reported only once,' and in that case the stenosis was part of widespread vascular disease.Our patient, a 53 year old woman, had hypertension and uraemia, and radiological investigation and laparotomy showed extensive periaortic fibrosis extending to the left ureter and the right renal artery; she had a large left kidney and a small right one.No other abnormalities were found, and ureteric transplantation led to recovery.The rare simultaneous occurrence of a large and a small kidney may indicate a diffuse retroperitoneal lesion like retroperitoneal fibrosis.
ABSTRACTS, A VALUABLE FEATURE.DANGER OF UNPROTECTED FIREPLACES.
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High-throughput sequencing identified MIR-193a as a potential biomarker of non-alcoholic fatty liver disease activity
Authors: Katherine Johnson, Peter J Leary, Matthew J Barter, Sarah H Charlton, Olivier Govaere, Simon Cockell, Mattias Ekstedt, Karine Clement, Jörn M. Schattenberg, Vlad Ratziu, Elisabetta Bugianesi, Ann K Daly, Quentin Anstee
Journal: Journal of Hepatology (2020)
Hyperbaric oxygen therapy in tetanus
Authors: J. S. Milledge
Journal: JAMA (1968)

Following the successful use of hyperbaric oxygen in<i>Clostridium welchii</i>infections, occasional cases of tetanus were treated by this method. The first series published was by Pascale et al<sup>1</sup>who reported dramatic improvement in most of their nine patients. Treatment consisted of one to three treatments of two hours' duration. No complications or difficulties were encountered and all except one patient appeared to make a rapid recovery. Other workers had rather less favorable experience. Winkel and Kroon<sup>2</sup>treated seven patients and considered the therapy to be moderately successful. Brummelkamp,<sup>3</sup>with seven patients, could not see any definite effect on their condition except for some relaxation of trismus. We report our experience of treating eight patients with tetanus: three neonates, three children, and two adults. These cases were all of severe tetanus, ie grade 4 or 5 of Patel and Joag's<sup>4</sup>classification, the spasms of which were
Cinquante techniques chirurgicales de Henry-Delagenière.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Costs and benefits of hepatitis prophylaxis
Authors: D. Egilman
Journal: JAMA (1984)

<h3>To the Editor.—</h3> Dr Hamiltons<sup>1</sup>article evaluating criteria for the use of hepatitis prophylaxis in medical personnel is misleading in several respects. Dr Hamilton states that prior to the initiation of a prevention strategy, it is necessary to "assess the costs and expected benefits of these strategies." This is contrary to the Occupational Health and Safety Administration (OHSA) Act of 1970, and the interpretation of that law as expressed by the Supreme Court in the case of American Textile Manufacturers Institute, Inc, et al<i>v</i>Donovan et al. The OHSA Act states that preventive measures must be implemented when they are<i>feasible</i>(Public Law 91-596). While economics is a part of feasibility, the Supreme Court has ruled that unless the control measure would put an entire industry out of business, an economic argument cannot prevent the implementation of a control measure. Furthermore, Dr Hamilton's argument is troubling from an
Dying
Authors: Helle Mathiasen
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Jaundiced Newborn
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Presence and Distribution of Mast Cells in the Human Gastrointestinal Tract at Autopsy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sulfation and Glucuronidation as Competing Pathways in the Metabolism of Hydroxamic Acids: The Role of N,O-Sulfonation in Chemical Carcinogenesis of Aromatic Amines
Authors: Gerard J. Mulder, John H. N. Meerman
Journal: Environmental Health Perspectives (1983)

Aromatic amines can be metabolized by N-acetylation and N-hydroxylation to hydroxamic acids; these subsequently are conjugated to form the N,O-sulfonate and N,O-glucuronide conjugates. The N,O-sulfonates are highly labile metabolites that generate reactive intermediates involved in the covalent binding of the parent compound to protein, RNA and DNA, as well as to low molecular compounds like glutathione. This paper discusses methods used to decrease sulfation in vivo, and thereby to enhance the formation of the more stable N,O-glucuronides from N-hydroxy-2-acetylaminofluorene and N-hydroxy-4-acetylamino-4'-fluorobiphenyl. Acetaminophen pretreatment decreases the sulfate availability, but results in many side effects that complicate the analysis of the results. An 8% casein diet reduces the sulfate availability in the rat to approximately 20% of control and thus offers an effective approach to decrease sulfation. The most effective selective inhibition of sulfation is by pentachlorophenol, which very strongly reduces N,O-sulfonation of both hydroxamic acids, and selectively inhibits the formation of DNA adducts that have retained the N-acetyl group. This inhibitor and the related 2,6-dichloro-4-nitrophenol can be employed to study the role of sulfation of hydroxamic acids in initiation and promotion of tumor formation by aromatic amines.
Hyperthermia, still experimental, may win place in cancer therapy
Authors: R. S. Johnson
Journal: JAMA (1981)

Oncologists and basic researchers at more than 40 universities and cancer centers are developing and testing methods of heating tumors to induce their regression. In one of the more novel of these methods, a patient's blood is heated externally and returned to circulate in his body. This method of hyperthermia, applied to the whole body or regions of it, has been used to treat more than 400 cancer patients. Hundreds more have been treated with various other experimental methods of hyperthermia within the last decade. Its use has increased rapidly in recent years as have reports that it effects tumor regression and prolongs survival in patients whose cancers are less than responsive to conventional therapy. The skepticism with which these reports were received a few years ago has matured to almost acceptance on the part of many oncologists, though hyperthermia has not yet been tested in a randomized study. The
TREATMENT OF SYPHILIS BY INHALATIONS OF MERCURIAL VAPOR.
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intubation of the Trachea in the Critical Care Setting-Reply
Authors: Charles Natanson
Journal: JAMA (1985)

<h3>In Reply.—</h3> The comments by Drs Watson and Lumb regarding our article help to focus attention on some of the difficult problems involved in writing an article reviewing a common, but exceedingly important, technique such as tracheal intubation. The CONCEPTS IN EMERGENCY AND CRITICAL CARE section was initiated in response to a need expressed by American physicians. These doctors noted that providing optimal medical care for the critically ill patient is one of the most important tasks facing the medical profession in the 1980s, yet very few current, accurate, and concise reviews summarize the major topics in this rapidly evolving field. The writing guidelines for this section call for a concise (2,000 word, 15 reference) summary of specific topics. Conforming to these guidelines, we (and other section authors) provide a good overview, highlight important specific topics, emphasize potential pitfalls and complications, and point the serious pupil in the correct direction
Effect on the canine Eck fistula liver of intraportal TGF-β alone or with hepatic growth factors
Authors: A Francavilla
Journal: Hepatology (1992)

Transforming growth factor-β canceled the hepatocyte proliferation caused by transforming growth factor-α when the two substances were mixed and administered through a disconnected central portal vein branch after creation of an Eck fistula. In contrast, transforming growth factor-β had no antidotal action on the stimulatory effects of insulin or full test doses of insulinlike factor-2, hepatocyte growth factor, epidermal growth factor or triiodothymanine. A minor antidotal effect on hepatic stimulatory substance activity could be detected, but only with hepatic stimulatory substance was given in doses smaller than those known to cause maximum stimulatory response. These results suggest a highly specific pharmacological and physiological interaction between transforming growth factor-α and transforming growth factor-α in the modulation of liver growth control. (HEPATOLOGY 1992;16:1267–1270.)
Transplantation
Authors: J. Michael Millis
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Premarital rubella screening in Rhode Island
Authors: E. Lieberman
Journal: JAMA (1981)

Rhode Island law requires that rubella serological screening be done for most female marriage license applicants. To evaluate the effect of the law, 203 rubella-susceptible women detected through premarital screening over a four-month period in 1978 were surveyed. Of those responding, 37% had been immunized, 21% were pregnant or infertile, and 42% were eligible for immunization but had not received vaccine. Premarital immunization occurred most frequently when physicians advised and directly offered vaccine. A survey of primary care physicians indicated that 24% immunized none of their rubella-susceptible patients detected by premarital screening. (<i>JAMA</i>1981;245:1333-1335)
Facts about abortions.
Journal: BMJ (1973)

BRITISH MEDICAL jOURNAL 26 MAY 1973 the blood is achieved.However, in severe cases of pulmonary oedema flow rates of 20 l./min may be insufficient, so that severe and progressive respiratory acidosis develops.In such cases intermittent positive-pressure ventilation,' and in the most extreme cases continuous positive-pressure ventilation,6 have been suggested.Rotaiting tourniquets may be used to produce a temporary reduction in ventricu- lar filling pressure.The acute form of pulmonary oedema is a medical emer- gency and presents a striking clinical picture.Laboratory measurements of respiratory and cardiac function and blood gas tensions may show gross abnormalities.It is not sur- prising that the improved understanding of its pathophysio- logy and the recognition that non-cardiac percipiating factors are increasingly important has led to a policy in some cen- tres to admit patients with acute pulmonary oedema to intensive care units for immediate and close surveillance.Whether admission to such units is the best policy is still debated.P. F. Griner7 has reviewed the experience of aduJtt patients admitted to a general hospital with a diagnosis of acute pulmonary oedema for the year before and after the opening of an intensive care unit.In both years the num- bers of patients and their characteristics were broadly simi- lar.Few patients had evidence of acute myocardial infarction (13%).After the opening of the intensive care unit
Cancer Risk Assessment and Prevention: Where Do We Stand?
Authors: Alice S. Whittemore
Journal: Environmental Health Perspectives (1989)

This paper reviews selected aspects of progress and setbacks in cancer risk assessment and prevention during the four decades since the founding in 1947 of the Institute of Environmental Medicine at the New York University Medical Center. The period has been marked by substantial gains in quantifying the risks posed by exposures to known human carcinogens such as tobacco and ionizing radiation. By contrast, the search for sensitive and specific laboratory screens for human carcinogens has met setbacks, and epidemiological data still are needed to monitor the adverse effects of environmental exposures. The determination of acceptable levels of exposure to potential human carcinogens remains a formidable task, one for which no scientific framework yet exists. Future challenges in cancer risk assessment include the validation and use of biological markers of exposure and effective monitoring of risk among exposed populations. Future challenges in cancer prevention include the elimination of tobacco consumption and the acquisition of knowledge needed to prevent nutritionally and hormonally related cancers such as cancers of the bowel, prostate, and breast.
Ras-transduced diethylnitrosamine-treated hepatocytes have multiple metabolic alterations and develop into tumors of mixed phenotype in vivo Dept. of Medicine and Surgery, Washington University School of Medicine, and Dept. of Pathology*, St. Louis University, St. Louis, Mo.
Journal: Hepatology (1995)

E1-deleted adenovirus vectors (AdV) are important gene transfer vehicles for gene therapy and vaccination. Amplification of AdV must take place in cells that express the adenovirus E1A and E1B genes. Sequence homology between AdV and the E1 genes integrated within the complementing cells should be minimal to reduce the odds of generating replication-competent adenovirus (RCA). The present study describes the establishment of AdV complementing cells constructed by stable transfection of the minimal E1A and E1B genes into human lung carcinoma (A549). Because some transgene products can be cytotoxic, the cells were engineered to stably express the repressor of the cumate-switch (CymR) to silence transgene transcription during vector growth. For regulatory compliance and to facilitate the scale-up, the resulting complementing cells (SF-BMAdR) were adapted to serum-free suspension culture. The best clone of SF-BMAdR produced AdV carrying an innocuous transgene to the same level as 293 cells, but titers were better for AdV carrying transgene for a cytotoxic product. Elevated titers were maintained for at least two months in suspension culture in the absence of selective agent and the cells did not produce RCA. Because of their advantageous properties, SF-BMAdR cells should become an important tool for developing large-scale production processes of AdV for research and clinical applications.