tbuckley/cabot-search huggingface dataset:
Abstract 1280: Inhibition of cellular FLICE-inhibitory protein and induction of Death Receptor 5 expression is a major component of δ- tocotrienol-induced apoptosis in pancreatic cancer cells
Authors: Anying Zhang, Rony A. Francois, Pamela J. Hodul, Kazim Husain, Steven Shivers, Domenico Coppola, Said M. Sebti, Mokenge P. Malafa
Journal: Cancer Research (2010)

Abstract Background: Previous pre-clinical studies have demonstrated that δ-tocotrienol, is the most bioactive natural vitamin E compound against pancreatic cancer. δ-Tocotrienol induces growth arrest and apoptosis in several human pancreatic cancer cell lines; however, the underlying mechanism remains unknown. In this study, we evaluated the role of the extrinsic and intrinsic apoptotic signaling pathways in δ-tocotrienol-induced apoptosis. Also, we investigated the modulation of cellular FLICE-inhibitory protein (c-FLIP) and death receptor 5 (DR5) by δ-tocotrienol, and the involvement of c-FLIP down-regulation and DR5 up-regulation in δ-tocotrienol-induced apoptosis. Methods: We examined δ-tocotrienol induced apoptosis in human pancreatic cancer cell lines in vitro and in vivo. We used western blot and immunohistochemistry to determine the expression of DR4, DR5, Caspase 8, Caspase 9, Caspase 3, c-FLIP, and PARP. The effect of combination treatment with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and δ-tocotrienol was also determined. We examined the cellular effects of DR5 knockdown using small interfering RNA oligonucleotides, and c-FLIP overexpression using c-FLIP cDNA, on δ-tocotrienol-induced apoptosis using various assays. Results: Delta-tocotrienol activated caspase-8 and its downstream caspases but not caspase-9. Caspase-8 specific inhibitor abrogated δ-tocotrienol-induced apoptosis whereas caspase-9 specific inhibitor did not, indicating that δ-tocotrienol induces caspase-8 -dependent apoptosis. c-FLIP was rapidly down-regulated by δ-tocotrienol in all of the tested cell lines. Delta-tocotrienol up-regulated DR4 and DR5 significantly and enhanced TRAIL-induced apoptosis. Enforced expression of ectopic c-FLIP, and DR5 knockdown partially abolished δ-tocotrienol-induced apoptosis. δ-Tocotrienol inhibition of pancreatic tumor growth in SCID mice was associated with significant induction of apoptosis, activation of caspase 8, and down-regulation of c-FLIP expression. Conclusion: We conclude that DR5 up-regulation and c-FLIP down-regulation contributes to δ-tocotrienol-induced apoptosis in pancreatic cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1280.
Progress Toward Global Poliomyelitis Eradication, 1999
Journal: JAMA (2000)

In 1988, the World Health Assembly resolved to eradicate poliomyelitis globally by 2000. Since then, substantial progress has been reported by all countries where polio is endemic in implementing the recommended polio eradication strategies (i.e., achieving and maintaining high routine coverage with oral poliovirus vaccine [OPV]; conducting National Immunization Days [NIDs] to rapidly decrease poliovirus circulation; establishing sensitive surveillance systems for polio cases and poliovirus; and carrying out mopping-up vaccination activities to eliminate the remaining reservoirs of poliovirus transmission). Although much progress has been made in many countries, substantial obstacles remain, particularly in 14 priority countries (i.e., global reservoir countries or countries with ongoing armed internal strife or civil war). This report updates progress during 1998 toward the global eradication target and describes accelerated activities to achieve the 2000 goal.
ORGANO-THERAPY IN UREMIA.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myocardial viability in chronic ischemic left ventricular dysfunction: A prospective study comparing intracoronary myocardial contrast echocardiography, Low dose dobutamine echocardiography and rest-redistribution thallium imaging Lieng H. Ling, Timothy F. Christian, Sharon L. Mulvagh, Mary F. Hauser, Rick A. Nishimura, Patricia A. Pellikka. Mayo Foundation, Rochester, MN
Journal: Journal of the American College of Cardiology (2001)
Evaluation of a New Uricosuric Diuretic—Ticrynafen
Authors: Mary Ellen Kosman
Journal: JAMA (1979)

Ticrynafen is an orally administered diuretic that is similar to the thiazides in its therapeutic actions, but, unlike the thiazides, it increases urate excretion and lowers serum uric acid levels. Ticrynafen is useful in the treatment of hypertension and in selected cases of chronic congestive heart failure. At present, it appears to be indicated primarily in patients with these disorders who have a history of gout. Patients who are currently receiving a thiazide should not have their therapy arbitrarily changed to ticrynafen because of asymptomatic hyperuricemia. (<i>JAMA</i>242:2876-2878, 1979)
New twist in possible relationship between vasectomy, atherosclerosis
Authors: W. A. Check
Journal: JAMA (1981)

During the last few years, research in primates showing that vasectomy can aggravate the development of atherosclerosis has caused considerable anxiety among men who have had or are contemplating having vasectomies. Results of the most recent primate research indicate that the extent of atherosclerosis in vasectomized vs control (sham-operated) monkeys may be linked to the animals' serum cholesterol levels. Speaking at the meeting of the American Association of Pathologists in Atlanta, Thomas B. Clarkson, DVM, of the Arteriosclerosis Research Center, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC, said that he saw the greatest difference in the extent of arterial plaque between vasectomized and control monkeys when the one third of animals with the most extensive lesions in each treatment group were compared. Another aspect of the project was carried out by Nancy Alexander, PhD, of the Oregon Regional Primate Research Center, Beaverton, who found that antisperm antibodies
Characterization of paclitaxel (Taxol&lt;SUP&gt;®&lt;/SUP&gt;) sensitivity in human glioma- and medulloblastoma-derived cell lines
Authors: Sheng Hong Tseng, Michael S. Bobola, Mitchel S. Berger, John R. Silber
Journal: Neuro-Oncology (1999)

Paclitaxel (Taxol ® ), a cytotoxic natural product that disrupts microtubule integrity, is being clinically evaluated for use against gliomas.We examined paclitaxel-induced killing in seven cell lines derived from human malignant astrocytic gliomas and medulloblastomas with the goal of characterizing range of sensitivity, contribution of Pglycoprotein 170-mediated drug ef ux to resistance, and cross-resistance with alkylating agents.Exposure to paclitaxel for 8 h or less produced biphasic survival curves for all lines, with 40-75% of cells comprising a subpopulation that was 9-26 times more resistant to paclitaxel than the more sensitive fraction.Increasing exposure to 24 h eliminated the resistant subpopulation, increasing sensitivity 50-to 400-fold.The dose producing one log of kill (LD 10 ) after a 24-h exposure ranged from 4 to 18 nM, comparable to concentrations in the cerebrospinal uid of brain tumor patients given a 3-h infusion of paclitaxel.Concurrent exposure to paclitaxel and either nimodipine or verapamil, inhibitors of P-glycoprotein activity, did not increase sensitivity, demonstrating that the vefold range in sensitivity was not due to P-glycoprotein-mediated drug ef ux.Importantly, there was no correlation between LD 10 for paclitaxel and LD 10 for 1,3-bis(2-chloroethyl)-1-nitrosourea, streptozotocin, and temozolomide, indicating no expression of cross-resistance to these different classes of tumoricidal agents.Our results suggest that greater clinical ef cacy of paclitaxel against malignant brain tumors may be obtained by infusion for 24 h or longer and support the use of paclitaxel in combination with alkylating agents.
European Perspectives
Authors: Otmar Pachinger, Fritz Kaindl
Journal: Circulation (2010)

In the year 2014 or thereabouts, the Medical University of Innsbruck will have a brand-new cardiac centre based on a cross-specialty philosophy that Professor Pachinger (among others) believes is the future face of cardiovascular medicine.Making the case for a new facility to reflect the evolution in cardiac care during his career, he says, "It is my last challenge, my last 'child.'I want to do something for the future!It will be on the main campus and will have all the cardiovascular specialists in 1 centre of excellence.The plan is to have surgical and coronary intensive care units next to each other, joined research labs, joined imaging modalities, and intensive interaction among the
Glutaraldehyde colitis
Authors: H.-H. Yen, Y.-Y. Chen
Journal: Endoscopy (2007)

A previously healthy, 69-year-old woman underwent a screening colonoscopy in November 2005. A 1-cm polyp was found in the sigmoid colon and was resected by snare polypectomy. The patient developed mild lower abdominal pain and passed some bloody stools 6 hours after the procedure. She was subsequently admitted and a sigmoidscopy was performed without bowel preparation in order to evaluate the postpolypectomy bleeding. The sigmoidscopy revealed markedly inflamed mucosa, but no ulceration (Figure [1]). During the same period, a total of six patients developed similar symptoms, symptoms that have not been encountered in our endoscopy unit in the past 20 years. Abdominal computed tomography performed in another similar patient (aged 72 years) showed involvement of the rectum and sigmoid colon only (Figure [2]). All the microbiological studies in these patients were negative. The patient’s symptoms resolved 3 days after bowel rest and intravenous fluid supplementation.
THE SURGICAL ASPECTS OF MAJOR NEURALGIA OF THE TRIGEMINAL NERVE.A REPORT OF TWENTY CASES OF OPERATION ON THE GASSERIAN GANGLION, WITH ANATOMIC AND PHYSIOLOGIC NOTES ON THE CONSEQUENCES OF ITS REMOVAL.
Authors: HARVEY CUSHING
Journal: JAMA (1905)

<h3>Case 3.</h3> —Alex. D., a Polish shoemaker, 38 years of age, entered the Johns Hopkins Hospital for the second time in January, 1900. <h3>History.</h3> —His neuralgia was of comparatively short duration, having been present for only two years. It had originated in the supraorbital territory, had invaded the second division the following year, and in March, 1899, a peripheral neurectomy of the supraorbital and infraorbital nerves was performed. This had given him only temporary relief and after a few months the pain returned and the lower, third division, had begun to transmit impulses of pain. There was also a suboccipital extension. The case was a typical one of tic douloureux with an involvement of all three divisions of the right side, but was not an instance of the extreme type of the disease. <h3>Operation.</h3> —January 15, 1900. Chloroform. The zygoma was not excised in this case. Enucleation of the ganglion (Fig. 10) presented no great difficulties, although it was my first experience with a bloody case. The wound was sufficiently dry after the extirpation to justify closure without drainage. The pulse during the operation was slowed to 50 beats a minute. Tissues examined by Dr. Barker.<sup>11</sup> <h3>Postoperative Notes.</h3> —Convalescence promised to be uninterrupted. The highest recorded temperature was 100 degrees the day after the operation. Healing occurred by primary
Despite 30-Year Low, Decline in Youth Homicides Has Slowed
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LAW &amp;amp; MEDICINE
Authors: Angela Roddey Holder
Journal: JAMA (1971)

In ten legal cases involving vasectomy, patients' claims have been based either upon a physician's negligence in performing surgery or upon breach of contract. To protect himself legally, the surgeon should make sure that both spouses understand that vasectomy does not guarantee sterility, but should nonetheless be considered a permanent method of sterilization. To make sure that the couple has understood all the possibilities and consequences of the operation, the physician should also obtain a written consent form.
Consensus conference. The impact of routine HTLV-III antibody testing of blood and plasma donors on public health
Journal: JAMA (1986)

A Consensus Development Conference organized under the auspices of the National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH) and the NIH Office of Medical Applications of Research brought together an interdisciplinary group to discuss protection of the nation's blood supply. The appearance of acquired immunodeficiency syndrome (AIDS) has challenged blood banks and public health personnel to eliminate blood containing the human immunodeficiency virus. Tests currently used to detect contaminated blood are not 100% reliable, and a positive test result poses problems in informing the donor, counseling, and confidentiality. Psychological stress for positive donors must be handled supportively, and self-deferral from blood donation should be encouraged. Autologous donation by persons facing elective surgery should be encouraged as research proceeds to develop more sensitive tests.
Discrimination in Eponymdom
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
&lt;TITLE&gt;Prevent hepatitis B infection&lt;/TITLE&gt;
Journal: JAMA (1999)

public service of JAMA and the AMA.The information and recommendations appearing on this page are appropriate in most instances; but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA and the AMA suggest that you consult your physician.This page may be reproduced noncommercially by physicians and other health care professionals to share with patients.Any other reproduction is subject to AMA approval.
MEDICAL RESEARCH COMMITTEE
Journal: BMJ (1917)

Whatever be the controversial passions of the 0ur, medical practitioners generally will welcome appointment, recently announced, of a Medical esearch.Committee in connection with the adminisfration of the National Insurance Act.The com- position of the Committee, too, will, we believe, c?ttimand the confidence of the profession, and it is,In our judgment, all to the good that such a Com- mittee should include members whose point of view not.that of the mere expert.Medical research a term of which much has been heard ln recent years, and it has, we think, very requently received an unduly narrow inter- pretation.To many minds, even yet, it carries suggestion of something done or attempted in a laboratory?this and nothing else.It means ^mical, bacteriological, or microscopical investi- gations; these and these alone, it is assumed, can aim the countenance and form of a truly scientific mquiry.No one will for a moment question the }alue and indeed the necessity for such activities, laboratory methods and results do not andCannot touch at all points the complex problems are associated with the cause and prevention ?disease.Confident, clear cut, and precise in 111 as these results often appear, they deal almost
The world's one crime
Authors: R. D. Liechty
Journal: JAMA (1976)

"THE WORLD'S one crime—is that babies grow dull," wrote Vachel Lindsay. Education was to have fashioned us all into bright, interesting people, who would naturally live bright, fulfilling lives. But something has gone wrong. Life and learning seem to have drained from us that sense of wonder and awe that used to sparkle in us as children. Recent national events have shocked us with the thought that education makes us more clever but not necessarily better or wiser. Most physicians remember those early feelings of wonder that came with learning about the expanding universe or viewing, for the first time, cell life through the microscope. Mystery at both ends of the universe—the exquisitely small and the infinite—delighted and intrigued us. But, between the two lies the "real" world. The world of bank balances and cancer, mortgages and prostatism, cocktail parties and the battered child. This is the world that, like
Circulatory Cavitation: Bubbles in the Blood
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Late intensification therapy for acute leukemia in remission. Chemotherapy and immunotherapy
Authors: G. P. Bodey
Journal: JAMA (1976)

Nineteen patients In continuous complete remission of acute leukemia for at least one year received late Intensification therapy, after which they received no further chemotherapy, but most received BCG Immunotherapy. Five patients have relapsed. The 14 patients still in remission have been followed up for at least 60 weeks after late intensification, with a median time of 98 weeks. The length of complete remission subsequent to a comparable time was 44 weeks for a reference control group and 24 weeks for a matched control group. These results support this type of approach for long-term control of acute leukemia in adults. (<i>JAMA</i>235:1021-1025, 1976)
Endoreduplication in Acute Leukemia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal