tbuckley/cabot-search huggingface dataset:
RHEUMATOID ARTHRITIS: A THREE-DISEASE GROUP.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The diagnosis of a lienunculus
Authors: K. M. Bron
Journal: JAMA (1968)

The preoperative diagnosis of a lienunculus (splenunculus) was made by selective celiac arteriography in a previously splenectomized patient with hereditary spherocytosis and recurrent anemia. This represents, to our knowledge, the first report in which a lienunculus has been demonstrated using this method. It is suggested that selective splanchnic arteriography be performed whenever clinical suspicion indicates the possible presence of a lienunculus.
Unproven Methods of Cancer Treatment: Anticancergen Z-50 and Zuccala Lytic Test
Authors: George Zuccala
Journal: CA A Cancer Journal for Clinicians (1962)

Unproven Methods of Cancer TreatmentThe following statement on Anticancergen Z-50 and Zuccala Lytic Test, meth ods proposed by George S. Zuccala, Sc
Rheumatology
Authors: P. Hickling
Journal: Annals of the Rheumatic Diseases (1990)

clinical, biological, and experimental research in rheumatology, but excludes general reviews.It will be confined to medical works published or accepted for publication during the past four years.The value of the prize is 2-5 million Italian liras.It should be written in Italian, French, German, Spanish, or English.
Reply
Authors: Cristina Bosetti, Fabio Levi, Paolo Boffetta, Franca Lucchini, Eva Negri, Carlo La Vecchia
Journal: Hepatology (2008)

We thank Dr. Duberg and Dr. Hultcrantz for their interest in our work. We agree with them that the apparent fall in mortality rates from hepatocellular carcinoma (HCC) in Sweden during the mid-1990s may reflect changes in coding practices more than real variations in mortality, as we already stated in our article.1 They suggested to include liver cancer unspecified together with HCC in the analysis of mortality trends. Unspecified liver cancers, however, include a heterogeneous group of (mainly secondary) neoplasms, which is broadly variable across countries and time periods.2, 3 It is therefore difficult to make any consistent inference on such a heterogeneous group. More important, most other countries considered did not show sharp changes in HCC mortality over the 25-year period analyzed. It is therefore unlikely that the problem noted for Sweden by ourselves and Dr. Duberg and Dr. Hultcrantz applies to a similar extent to most other countries as well. Nevertheless, we can only stress again the importance of interpreting with due caution mortality and incidence data on (primary) liver cancer, given the problems in reliability and validity of certification data for this neoplasm, mainly due to the difficulty in distinguishing primary and secondary liver neoplasms. Cristina Bosetti*, Fabio Levi , Paolo Boffetta , Franca Lucchini , Eva Negri*, Carlo La Vecchia* §, * Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy, Unité d'Épidémiologie du Cancer et Registres Vaudois et Neuchâtelois des Tumeurs, Institut de Médecine Sociale et Préventive (IUMSP), Universitè de Lausanne, Lausanne, Switzerland, International Agency for Research on Cancer, Lyon, France, § Istituto di Biometria e Statistica Medica, G.A. Maccacaro,, Università degli Studi di Milano, Milan, Italy.
Dr. Ratzkowski, Not Ratkowski
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Les Actualites Physiotherapiques . Edited by Dr. Duhem. II. Radiotherapie, Vol. 3, La Radiothérapie pénétrante by Ledoux-Lebard and Etienne Piot. Paris; Gauthier-Villars et Cie, 1930. 80 pages. Price 15 fr.
Journal: New England Journal of Medicine (1930)
Respiratory Medicine
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lineage switch from acute myeloid leukemia to acute lymphoblastic leukemia: Report of an adult case and review of the literature
Authors: A. Lounici, P. Cony‐Makhoul, P. Dubus, F. Lacombe, J.P. Merlio, J. Reiffers
Journal: American Journal of Hematology (2000)

Lineage switch from AML to ALL is an extremely rare phenomenon, and we report the case of an adult diagnosed with AML at 46 years of age who relapsed with ALL. At initial diagnosis, blast cell morphology and immunophenotyping were consistent with the diagnosis of M4-AML. Complete remission was achieved, and the patient underwent autologous BMT. At relapse, six months after ABMT, blast cells were different from those seen at initial diagnosis, for morphology (L2-ALL), cytochemistry, and immunophenotyping. The karyotype was normal at both diagnosis and relapse. No evidence of bcr-abl fusion genes was found by RT-PCR. Monoclonal IgH and TCR γ gene rearrangement were evidenced by PCR analysis at relapse but not on blast cells at AML diagnosis. Am. J. Hematol. 65:319–321, 2000. © 2000 Wiley-Liss, Inc.
Sonnets for Anne
Authors: Jack Coulehan
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biochemistry of Uric Acid and Its Relation to Gout
Authors: J. Edwin Seegmiller, Leonard Laster, R. Rodney Howell
Journal: New England Journal of Medicine (1963)

HyperuricemiaUric Acid MetabolismSo far as is known today, uric acid serves no biochemical function in the body other than being an end product of purine metabolism. The metabolically important purines, adenine and guanine, serve as building blocks for nucleic acids and as components of cofactors for a wide variety of biochemical reactions. Adenine and guanine originate either from dietary purines or from a de novo biosynthesis. The purines formed in excess of the body's requirements, as well as a portion of those arising from tissue catabolism, undergo an irreversible oxidation to uric acid. Purine biosynthesis in bacteria has . . .
SKIN FERMENTS
Authors: Edna Sexsmith, William F. Petersen
Journal: The Journal of Experimental Medicine (1918)

That a definite change in the reactivity of the skin takes place during the transition from infancy to childhood has been repeatedly noted. Rolly (5), working with a variety of bacterial toxins, found that infants did not react, but that reactions occurred with advancing age. Similarly Tenner (6), using Witte's peptone, colon bacilli, and tuberculin observed that at about the period that the skin of children became increasingly sensitive to tuberculin, a corresponding reactivity was manifest toward the other antigens. It seems possible to us that this phenomenon is related to the alteration in the ferments of the skin that takes place during the transition period. Thus while the protease of the adult type of skin causes a definite autolysis, that of the fetal skin does not, the synthetic potential evidently predominating. Of greater significance seems to be the fact that the skin of the young animal contains peptidase to a considerable amount, while the adult skin seems to be without this ferment activity. If we assume that the disintegration of the native protein of the antigen is essential in eliciting certain skin tests, it would seem probable that the splitting would be less apt to take place in the young skin in which the lytic effects of the ferments are relatively suppressed. On the other hand, the young skin, containing peptidase, would be able to digest rapidly any antigen consisting of partially hydrolyzed proteins—as tuberculin—and in this way detoxicate and remove the noxious material. From these considerations the undoubted alteration of the skin reactivity taking place after infancy seems definitely correlated with changes in the proteolytic ferments. In how far they enter into and alter the specific reactions cannot be determined from the limited data so far available. Of the other ferments, the lipases, as pointed out by Porter, are possibly of importance in the resistance of the skin to tuberculous infection. It will be observed from the table that the activity of these skin ferments is less manifest in their action as esterases, on ethyl butyrate, than on the neutral fats used, oleic oil and butter fat, in this way differing from the activity of the serum. The relative resistance of the skin to tuberculous infection can, however, hardly be due to the activity of the lipase alone, for it must be kept in mind that the lepra bacillus, also rich in lipoids, is enabled to proliferate well within the epithelial tissues.
Abdominal Bruits
Authors: Michael J. McLoughlin
Journal: JAMA (1975)

The results of abdominal auscultation were correlated with abdominal angiograms in 503 patients. Bruits were heard in 106 (21%). The majority of bruits were in the epigastrium, mainly because of a high incidence of celiac artery stenosis usually of the extrinsic compression type. Sixty-seven patients had stenoses or occlusions of one or more renal arteries and 27 (40%) had bruits. Most of these patients, however, had other possible causes for their bruits, usually related to atherosclerosis of coincidental celiac compression. Collateral channels were considered to be the cause of epigastric bruits in eight of ten patients with complete occlusion of the celiac artery and in two patients with splenic artery occlusions. Collateral channels may be partly responsible for bruits in many patients with celiac artery stenosis. (<i>JAMA</i>232:1238-1242, 1975)
PRE-EXISTING CARDIOVASCULAR DISEASE INCREASES RISK OF ATRIAL ARRHYTHMIA IN CANCER PATIENTS TREATED WITH IBRUTINIB
Authors: Juan Carlo Avalon, Jacob Fuqua, Seth Deskins, Sonya Inderbitzin-Brooks, Chelby Wakefield, Austin King, Tyler Miller, Lauren Veltri, Kelly Ross, Abraham Kanate, Michael Craig, Christopher Bianco, Midhun Malla, Brijesh Patel
Journal: Journal of the American College of Cardiology (2021)
Hibiscrub in acne
Authors: G Davidson, Alma Simmonds, F Abdul, Jabbar Abeysirigunawardana, A El-M Abu-Omar, M Adams, C Ajomo, G Aletor, M Ali, S Al-Malaika, A Al-Meshari, E Ayanka, M Balsdon, J Barr, A Bateman, N Begum, J Bevan, J Bolton, J Brash, Pamela Buck, A Chakrabarti, D Chakrabortti, Y Chaudhuri, P Cheung, D Coats, M Corvin, G Damole, B Dikshit, H Ejiumudo, A El, A El-Awady, A El-Farra, A El-Gaaly, K El-Ghonaimy, I Fabunmi, H Farquhar, J Fassler, K Fong, J Ford, R Frazer, T Gaafar, F Gasde, M Graham, R Green-Thompson, N Hambly, C Harmston, R Haskins, G Hastwell, Kathleen Jennison, J Kane, L Kapadia, K Karia, J Kasule, A Kent, C Kessy, M Kleida, T Kopenhager, P Labanya, T Lee, Catherine Lim, Olivia Lore, E Mcdonald, J Mcguinness, A Mclaughlin, F Mander, N Naidoo, U Nath, R Neale, R Nelson, L Ng, Grace North, J Nwaogbo, J Oats, I Obineche, K Patel, G Paul, Eleanor Pickering, A Pinshaw, J Pogmore, W Reid, H Rodeck, S Saigol, U Sathia, C Sornalingam, E Speck, M Srivastava, G Storey, S Thekkemadathil, A Tikreeti, C Van, Der Merwe, S Van, P Vinall, L Wald, J Walton, D Wilde, M Wolfson, J Wontumni, R Young-Thompson, M El, T Youssif
Journal: BMJ (1975)
362PD Development and validation of a nomogram to predict the probability of recurrence in patients with major salivary gland cancers
Authors: C-Y. Hung, C-H. Lu, C-T. Liu, P-H. Chang, K-Y. Yeh, S-H. Li, Y-C. Lin, T-S. Yeh, Y-S. Hung, W-C. Chou
Journal: Annals of Oncology (2016)
Oncology
Authors: Maryann Roper
Journal: JAMA (1989)

Preliminary results from a national survey of 24 000 adults show that Americans are not making optimal use of tests for the early detection of cancer.<sup>1</sup>In 1987, the National Cancer Institute (NCI), Bethesda, Md, collaborated with the National Center for Health Statistics, Hyattsville, Md, to produce a cancer supplement to the National Health Interview Survey that consists of a 30-minute at-home interview on knowledge of, attitudes about, and behavior toward cancer. Data from the first quarter of this yearlong survey have been reviewed; final analysis of the basic findings should be available by the summer of 1989. In the first quarter, 5723 adults (2426 men and 3297 women) responded to the cancer control section of the questionnaire. This included questions regarding common screening tests for the early detection of cancer, such as Papanicolaou smears, breast physical examinations, mammography, rectal examinations, and stool tests for occult blood. The survey also
Physiologic Basis and Interpretation of Common Indices of Respiratory Mechanical Function
Authors: Jeffrey M. Drazen
Journal: Environmental Health Perspectives (1976)

Tests of pulmonary mechanical function may be used in determining the prominent site of pulmonary reaction to intervention. Responses may be localized from a knowledge of changes in lung resistance and compliance. A peripheral airway or parenchymal response is characterized by a decrease in lung compliance. A central airway reaction is characterized by an increase in pulmonary resistance. In mixed reactions both parameters may change. In this communication some of the physiologic determinants of pulmonary resistance and compliance are discussed and examples of localized responses given.
DIGITAL SYPHILIS OF MEDICAL PRACTITIONERS.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Change in Public Perspective on Cholesterol and Heart Disease
Authors: Beth Schucker
Journal: JAMA (1987)

The National Heart, Lung, and Blood Institute, Bethesda, Md, and the Food and Drug Administration, Washington, DC, sponsored two national probability telephone surveys (N = 4000) of adults to assess attitudes and knowledge about heart disease risk from high blood cholesterol levels and the public's efforts to lower blood cholesterol levels. The first survey was conducted in 1983, before release of the results from the Lipid Research Clinics Coronary Primary Prevention Trial, which showed that a reduction in the blood cholesterol level reduced coronary heart disease; the second survey was conducted in 1986. The percentage of adults who believed that reducing high blood cholesterol levels would have a large effect on heart disease increased from 64% in 1983 to 72% in 1986, so that the importance attached to reducing high blood cholesterol levels approached that attributed to reducing smoking and high blood pressure. In 1983,35% of adults reported that they had their cholesterol level checked vs 46% in 1986. In both years, diet changes were most frequently chosen (&gt;60%) as ways to control the blood cholesterol level; reducing dietary fat was believed to be as important as reducing dietary cholesterol. By 1986, 23% of adults reported that they made dietary changes specifically to lower their blood cholesterol level, up from 14% in 1983. These comparative data show gains in public awareness and action relating to high blood cholesterol level risk. The data can be used to develop education programs. (<i>JAMA</i>1987;258:3527-3531)
Mayo Clinic Proceedings, Rochester, Minn
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation
Authors: Fumiyo Ikeda, Riko Nishimura, Takuma Matsubara, Sakae Tanaka, Jun-ichiro Inoue, Sakamuri V. Reddy, Kenji Hata, Kenji Yamashita, Toru Hiraga, Toshiyuki Watanabe, Toshio Kukita, Katsuji Yoshioka, Anjana Rao, Toshiyuki Yoneda
Journal: Journal of Clinical Investigation (2004)

Receptor activator of NF-κB ligand (RANKL) plays an essential role in osteoclast formation and bone resorption. Although genetic and biochemical studies indicate that RANKL regulates osteoclast differentiation by activating receptor activator of NF-κB and associated signaling molecules, the molecular mechanisms of RANKL-regulated osteoclast differentiation have not yet been fully established. We investigated the role of the transcription factor c-Jun, which is activated by RANKL, in osteoclastogenesis using transgenic mice expressing dominant-negative c-Jun specifically in the osteoclast lineage. We found that the transgenic mice manifested severe osteopetrosis due to impaired osteoclastogenesis. Blockade of c-Jun signaling also markedly inhibited soluble RANKL-induced osteoclast differentiation in vitro. Overexpression of nuclear factor of activated T cells 1 (NFAT1) (NFATc2/NFATp) or NFAT2 (NFATc1/NFATc) promoted differentiation of osteoclast precursor cells into tartrate-resistant acid phosphatase–positive (TRAP–positive) multinucleated osteoclast-like cells even in the absence of RANKL. Overexpression of NFAT1 also markedly transactivated the TRAP gene promoter. These osteoclastogenic activities of NFAT were abrogated by overexpression of dominant-negative c-Jun. Importantly, osteoclast differentiation and induction of NFAT2 expression by NFAT1 overexpression or soluble RANKL treatment were profoundly diminished in spleen cells of the transgenic mice. Collectively, these results indicate that c-Jun signaling in cooperation with NFAT is crucial for RANKL-regulated osteoclast differentiation.
Comparison of radioimmunoprecipitation with luciferase immunoprecipitation for autoantibodies to GAD65 and IA-2 
Authors: P. D. Burbelo, H. Hirai, A. T. Issa, A. Kingman, A. Lernmark, S-A. Ivarsson, A.b. L. Notkins, M. J. Iadarola
Journal: Diabetes Care (2010)