Association of Thoracic Aortic Aneurysm Size With Long-term Patient Outcomes
Authors: Matthew D. Solomon, Thomas Leong, Sue Hee Sung, Catherine Lee, J. Geoff Allen, Joseph Huh, Paul LaPunzina, Hon Lee, Duncan Mason, Vicken Melikian, Daniel Pellegrini, David Scoville, Ahmad Y. Sheikh, Dorinna Mendoza, Sahar Naderi, Ann Sheridan, Xinge Hu, Wendy Cirimele, Anne Gisslow, Sandy Leung, Kristine Padilla, Michael Bloom, Josh Chung, Adrienne Topic, Paniz Vafaei, Robert Chang, D. Craig Miller, David H. Liang, Alan S. Go, Norma Chow, Emily Chen, Katharine Dawson, Leslie Manace, Thomas Urbania, Scott Yang, Mario Pompili, Brian Cain, Osvaldo Yano, Hong Hua, Bian Wu, Guarav Sharma, Aaron Baker, Nayan Sivamurthy, Joy Garg, Thesalia Madriz, Honora Hui
Journal: JAMA Cardiology (2022)

The risk of adverse events from ascending thoracic aorta aneurysm (TAA) is poorly understood but drives clinical decision-making.To evaluate the association of TAA size with outcomes in nonsyndromic patients in a large non-referral-based health care delivery system.The Kaiser Permanente Thoracic Aortic Aneurysm (KP-TAA) cohort study was a retrospective cohort study at Kaiser Permanente Northern California, a fully integrated health care delivery system insuring and providing care for more than 4.5 million persons. Nonsyndromic patients from a regional TAA safety net tracking system were included. Imaging data including maximum TAA size were merged with electronic health record (EHR) and comprehensive death data to obtain demographic characteristics, comorbidities, medications, laboratory values, vital signs, and subsequent outcomes. Unadjusted rates were calculated and the association of TAA size with outcomes was evaluated in multivariable competing risk models that categorized TAA size as a baseline and time-updated variable and accounted for potential confounders. Data were analyzed from January 2018 to August 2021.TAA size.Aortic dissection (AD), all-cause death, and elective aortic surgery.Of 6372 patients with TAA identified between 2000 and 2016 (mean [SD] age, 68.6 [13.0] years; 2050 female individuals [32.2%] and 4322 male individuals [67.8%]), mean (SD) initial TAA size was 4.4 (0.5) cm (828 individuals [13.0% of cohort] had initial TAA size 5.0 cm or larger and 280 [4.4%] 5.5 cm or larger). Rates of AD were low across a mean (SD) 3.7 (2.5) years of follow-up (44 individuals [0.7% of cohort]; incidence 0.22 events per 100 person-years). Larger initial aortic size was associated with higher risk of AD and all-cause death in multivariable models, with an inflection point in risk at 6.0 cm. Estimated adjusted risks of AD within 5 years were 0.3% (95% CI, 0.3-0.7), 0.6% (95% CI, 0.4-1.3), 1.5% (95% CI, 1.2-3.9), 3.6% (95% CI, 1.8-12.8), and 10.5% (95% CI, 2.7-44.3) in patients with TAA size of 4.0 to 4.4 cm, 4.5 to 4.9 cm, 5.0 to 5.4 cm, 5.5 to 5.9 cm, and 6.0 cm or larger, respectively, in time-updated models. Rates of the composite outcome of AD and all-cause death were higher than for AD alone, but a similar inflection point for increased risk was observed at 6.0 cm.In a large sociodemographically diverse cohort of patients with TAA, absolute risk of aortic dissection was low but increased with larger aortic sizes after adjustment for potential confounders and competing risks. Our data support current consensus guidelines recommending prophylactic surgery in nonsyndromic individuals with TAA at a 5.5-cm threshold.