tbuckley/cabot-search huggingface dataset:
A Manual of Surgical Treatment.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rheumatic Fever and Rheumatoid Arthritis
Authors: E. G. L. Bywaters
Journal: BMJ (1965)

<h3>ABSTRACT</h3> After the end of the first epidemic episode of SARS-CoV-2 infections, as cases began to rise again during the summer of 2020, we at IHU Méditerranée Infection in Marseille, France, intensified the genomic surveillance of SARS-CoV-2, and described the first viral variants. In this study, we compared the incidence curves of SARS-CoV-2-associated deaths in different countries and reported the classification of SARS-CoV-2 variants detected in our institute, as well as the kinetics and sources of the infections. We used mortality collected from a COVID-19 data repository for 221 countries. Viral variants were defined based on ≥5 hallmark mutations shared by ≥30 genomes. SARS-CoV-2 genotype was determined for 24,181 patients using next-generation genome and gene sequencing (in 47% and 11% of cases, respectively) or variant-specific qPCR (in 42% of cases). Sixteen variants were identified by analysing viral genomes from 9,788 SARS-CoV-2-diagnosed patients. Our data show that since the first SARS-CoV-2 epidemic episode in Marseille, importation through travel from abroad was documented for seven of the new variants. In addition, for the B.1.160 variant of Pangolin classification (a.k.a. Marseille-4), we suspect transmission from mink farms. In conclusion, we observed that the successive epidemic peaks of SARS-CoV-2 infections are not linked to rebounds of viral genotypes that are already present but to newly-introduced variants. We thus suggest that border control is the best mean of combating this type of introduction, and that intensive control of mink farms is also necessary to prevent the emergence of new variants generated in this animal reservoir.
Heterosexually acquired HIV infection
Authors: F. M Cowan, P. J Flegg, R. P Brettle
Journal: BMJ (1989)

increase has been only 1 6'%o.Let this be compared with the previous five vears (under Wilson/ Callaghan), when the average annual growth was 3-6%.With 1-6% growth £100 of expenditure in 1979 would have increased to £115.36 in 1988.With 3 6% annual growth its value would have increased to £137.48.This represents a shortfall in revenue for 1988 of 19-15%.I am sure that many of the problems of the district health authorities would be solved if their present income was increased by that amount.Even worse, however, is the accumulated loss of funding over the period.With the same £100 base the total loss in income over those nine years is £103.40,equivalent to a loss of 89-6% of the 1988 annual budget.This will inevitably become rapidly
Highlights of This Issue
Journal: Clinical Cancer Research (2016)

The clinical suppression of the EWS-FLI1 transcription factor has not been achieved despite a known dependence of Ewing sarcoma on this target.Osgood and colleagues previously demonstrated that the DNA-binding compound mithramycin blocks the activity of the EWS-FLI1 transcription factor to suppress tumor growth in preclinical models.Unfortunately, the clinical translation of this compound as an EWS-FLI1-directed therapy was limited by toxicity.In this study, the authors optimized the structure of mithramycin and identified two second-generation analogues that maintain suppression of EWS-FLI1 but have improved toxicity profiles.
Only CT finds some ovarian cancer spread
Authors: John Henahan
Journal: JAMA (1983)

In the largest study of its kind carried out so far, computed tomography (CT) has proved more accurate in measuring the extent of ovarian carcinoma than conventional clinical examination. It can also in some cases prevent the need for more than one laparatomy, according to George R. P. Blackledge, BChir, MB, MRCP, and associates at Christie Hospital, Manchester, England. Among 75 women with ovarian carcinoma, CT scans revealed undetected disease in the uteri of 13 and on the pelvic side walls of 25, Blackledge told the recent annual meeting of the British Association for Cancer Research in York, England. In only four patients did clinical examination turn up disease not visualized by CT, he said. Further, the scanning revealed 72 abdominal tumors undetected by clinical examination, hematologic studies, ultrasound, routine liver biopsy, and other tests. Also, CT consistently identified previously undetectable retroperitoneal lymphadenopathy, hepatic metastases, and small amounts of ascites.
Psychology. A Study of Mental Life.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights from Recent Cancer Literature
Journal: Cancer Research (2015)

eIF4E in Development and in CancerAssembly of protein complexes at the mRNA cap facilitates translation.An important component of these complexes is the eukaryotic initiation factor 4E (EIF4E).Truitt and colleagues demonstrate that both overall development and levels of translation were normal in mice haploinsufficient for Eif4e.However, in the setting of transformation by MYC or RAS, both copies of Eif4e were required to fulfill translational demands, and selectively for translation of mRNAs encoding ROS scavengers.The researchers identified ("CERT" motif) elements within the 5 0 leaders of the mRNAs encoding these ROS scavengers that conferred sensitivity to levels of EIF4E.The fact that decreased levels of EIF4E were tolerated in normal cellular and developmental contexts but not in oncogenic contexts provides a further rationale to explore inhibitors of EIF4E as anticancer agents.(Image courtesy of
Highlights of This Issue
Journal: Clinical Cancer Research (2013)

KU-60019 is a novel and specific ATM kinase inhibitor that blocks the radiation-induced DNA damage response and potently radiosensitizes human glioma cells. To see whether KU-60019 would be an effective radiosensitizer in vivo, Biddlestone-Thorpe and colleagues utilized orthotopic human glioma xenograft models varying in p53 status and invasiveness. They show, for the first time, that an ATM kinase inhibitor significantly increases the survival of irradiated mice. Importantly, mutant p53 glioma was much more sensitive to KU-60019 radiosensitization than genetically matched wild-type glioma. Thus, an ATM kinase inhibitor may be an effective radiosensitizer and adjuvant therapy for patients with mutant p53 brain cancers.Navarro and colleagues analyzed the expression profiling of 664 microRNAs (miRNA) in mantle cell lymphoma (MCL) to identify biomarkers involved in the pathogenesis of the disease and clinically relevant subtypes. The differential miRNA expression profile identified 2 subgroups of the disease that differ in clinical and biologic characteristics. These miRNAs regulate relevant pathways in the pathogenesis of MCL, including DNA stress response, CD40 signaling, and chromatin modification. miR-34a was identified and validated as a new prognostic marker in MCL in cooperation with MYC overexpression.Notch pathway inhibitors are being investigated as targeted therapies in a wide range of cancers and can modulate signaling cascades regulating differentiation, survival, and growth. Chu and colleagues tested the effects of an oral γ-secretase inhibitor in xenografts generated from glioblastoma stem cells and identified suppression of clonogenicity and in vivo growth capacity that persisted long after treatment stopped. Their data provide further support for the use of γ- secretase inhibitors in treating malignant brain tumors and suggest that Notch blockade can have both acute and long-term effects on tumor biology.This cohort study and integrated analysis of data from 17 previous reports defines the characteristics of PIK3CA- and PTEN-mutated colorectal cancers. Day and colleagues show that phosphoinositide 3-kinase (PI3K) pathway mutation is prominent in proximal colon cancers, with PIK3CA exon 20 and PTEN mutations associated with features of the sessile-serrated pathway (MSI-high/CIMP-high/BRAF mutation) and PIK3CA exon 9 (and to a lesser extent exon 20) mutation associated with features of the so-called traditional serrated pathway of tumorigenesis (CIMP-low/KRAS mutation). Mutation status did not predict relapse in stage II/III colorectal cancer. These data highlight the PI3K pathway as a preferential therapeutic target in distinct colorectal cancer subtypes.
Illness Severity and Costs of Admissions at Teaching and Nonteaching Hospitals
Authors: Lisa I. Iezzoni
Journal: JAMA (1990)

This research examined the hypothesis that greater severity of illness explains the higher costs of hospitalizations at teaching compared with nonteaching hospitals. Medical records of 4439 cases within eight common conditions were reviewed at five tertiary teaching, five other teaching, and five nonteaching hospitals in metropolitan Boston, Mass. We assessed acute physiologic status, severity of the principal diagnosis, comorbidities, and functional status. The principal diagnosis was more severe for teaching hospital patients in four conditions, but few significant differences were found for the other severity dimensions by condition. Across all conditions combined, except for functional status, severity was significantly higher at teaching hospitals, but the absolute differences were small. After adjusting for diagnosis related groups, costs were higher at tertiary teaching compared with other teaching and nonteaching hospitals. Further adjusting for severity and other patient characteristics explained 18% (90% confidence interval, 4 to 33) of the higher costs at tertiary compared with nonteaching hospitals. (<i>JAMA</i>. 1990;264:1426-1431)
Nonanoxic Aerosol Arrhythmias
Authors: Nancy C. Flowers
Journal: JAMA (1972)

Cardiac arrhythmias were produced in dogs which were allowed to breathe aerosols propelled with fluorinated hydrocarbons. In spite of mixing with room air in ten animals, and careful maintenance of normal arterial oxygen tension, carbon dioxide tension, pH, base excess, and serum carbon dioxide level in six animals, the same general pattern of rhythm disturbances prevailed. These consisted mainly of slowing of the rate of the sinoatrial pacemaker with resultant junctional or ventricular escape rhythm and ultimate electrical asystole or ventricular fibrillation in eight animals, in spite of the fact that exposure to the agents was stopped at the earliest sign of rhythm change.
World No-Tobacco Day Targets Sports and the Arts
Authors: Phil Gunby
Journal: JAMA (1996)

SPORTS AND THE ARTS are the focus for this year's World No-Tobacco Day, which is set for May 31. This is the ninth consecutive year that the World Health Organization (WHO) has urged tobacco users to abstain for at least a day and perhaps for good (<i>JAMA</i>. 1989;261:13). The WHO, an autonomous unit within the United Nations system with main headquarters in Geneva, Switzerland, says the upcoming May 31 observance "is a unique opportunity to mobilize athletes, artists, and the [news] media, as well as the public in general, in support of the objective of promoting a society and a way of life where tobacco use is no longer an accepted norm." Still, tobacco promotion and many sports (as well as occasional cultural) events have been linked. But WHO officials say that the recent smoke-free history of the Olympic Games is encouraging as far as athletics are concerned. The 1988
Regional Variation in Cataract Extraction Rates and their Relationship with Resource Supply and Need
Authors: Hugh F Sanderson
Journal: Journal of the Royal Society of Medicine (1980)

There are large variations in cataract extraction rates between different regions of England, which may indicate differences in the availability of the operation in different parts of the country. Analysis shows that there is a relationship between the availability of ophthalmic beds and operation rates, but it is not possible to determine whether the bed supply determines the operation rate or vice versa.
Experimental Induction of Pancreatic Carcinomas in the Hamster With &lt;italic&gt;N&lt;/italic&gt;&lt;sup&gt;δ&lt;/sup&gt;-(&lt;italic&gt;N&lt;/italic&gt;-Methyl-&lt;italic&gt;N&lt;/italic&gt;-nitrosocarbamoyl)-&lt;sc&gt;L&lt;/sc&gt;-ornithine&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Daniel S. Longnecker, Thomas J. Curphey, Elna T. Kuhlmann, Barbara K. Schaeffer
Journal: JNCI Journal of the National Cancer Institute (1983)

Carcinomas of the pancreas, stomach, and breast, as well as mesotheliomas and ovarian stromal tumors, were induced in Syrian golden hamsters treated with Nδ-(N-methyl-N-nitrosocarbamoyl)-L-ornithine (MNCO), which has previously been shown to cause pancreatic acinar cell carcinomas in rats. The pancreatic carcinomas in hamsters appeared ductlike. The nonneoplastic and preneoplastic lesions induced in the hamster pancreas included cystic ductal complexes, tubular complexes, intraductal hyperplasia and atypical hyperplasia, focal eosinophilic metaplasia, and foci of atypical acinar cells. High doses of 654 mg MNCO/kg body weight were cytotoxic for acinar cells and caused atrophy of the pancreas. Alkaline elution analysis of DNA from acinar cells treated in culture with MNCO showed an increased rate of elution characteristic of single-strand breaks. A group of hamsters treated with a low dose of N-nitrosobis(2-oxopropyl)amine (BOP) developed pancreatic lesions similar to those seen when a subcarcinogenic dose of MNCO was given. The results suggest that MNCO affects both acinar and ductal cells in the hamster and that the response of the hamster pancreas to MNCO and BOP is similar in many respects.
AMA members retirement plan
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human Glue
Authors: James E. Casanova
Journal: Annals of Internal Medicine (1991)

Ad Libitum15 February 1991Human GlueJames E. Casanova, MDJames E. Casanova, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-4-344_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHuman glueis sticky stuffdries clearunseen butrips the fleshwhen pulled awayfetalfatal andinbetweenit bonds thecells andsoulseven whenyou'd ratherit notNot ionicnot covalentdifferentproduct of somecosmic firesometimes ticklessometimes stingssilentpotentparentalplatonicpassionateplain andperplexingA glancea touchwarm soup oran icy rescuebeingin love withbeingholds us alltogetherso tightlybut stillwe wonderwhy... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Milwaukee, Wisconsin PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 1991Volume 114, Issue 4Page: 344-344KeywordsCellsTouch Issue Published: 15 February 1991 PDF downloadLoading ...
Agricultural and Industrial Bacteriology.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Irreversible Brain Damage After Water Intoxication
Authors: Eleanor Lipsmeyer
Journal: JAMA (1966)

WATER intoxication is the term that Rowntree<sup>1</sup>applied to the syndrome resulting from extreme hypotonicity of body fluids. Since his description of this disorder in 1923, cases have been described in varied clinical settings. Although fatal cases have been reported, the impression conveyed by the literature on on this subject is that the prognosis is good with correction of hypotonicity. Cooke<sup>2</sup>states that permanent damage to the brain may occur as a sequela of water intoxication, but does not document this assertion. Certainly most case reports and reviews imply that the abnormal neurological state is completely reversible. It is the purpose of this paper to present two cases of water intoxication followed by permanent brain damage. <h3>Report of Cases</h3><h3>Case 1.—</h3> In October 1964, this 78-year-old woman had acute diverticulitis with intestinal obstruction, and a colostomy was performed. At that time the blood urea nitrogen (BUN) level was
Buoyant density of hepatitis C virus recovered from infected hosts: Two different features in sucrose equilibrium density-gradient centrifugation related to degree of liver inflammation
Authors: Tatsuya Kanto, Norio Hayashi, Tetsuo Takehara, Hideki Hagiwara, Eiji Mita, Masafumi Naito, Akinori Kasahara, Hideyuki Fusamoto, Takenobu Kamada
Journal: Hepatology (1994)

Hepatitis C virus is reported to have a low buoyant density in sucrose. To determine the density of hepatitis C virus in the circulation of infected hosts and its association with the degree of liver inflammation, we examined serum samples from 10 patients who were positive for both hepatitis C virus antibody (C100 antigen) antibody and serum hepatitis C virus RNA. After the serum was ultracentrifuged in sucrose density gradient (10 to 60), the hepatitis C virus RNA titer in each collected fraction was quantified by means of competitive reverse transcription-polymerase chain reaction. In samples from five blood donors, the hepatitis C virus RNA titer had a single peak at fractions with densities of 1.08 to 1.11 gm/ml. In samples from five patients with ALT abnormalities, the titer had two peaks at fractions with 1.09 to 1.10 gm/ml and 1.22 to 1.25 gm/ml. After the selected samples were treated with detergents and ultracentrifuged, the titer in the 1.08 to 1.11 gm/ml fractions decreased and that in the 1.22 to 1.25 gm fractions increased. This result implied that the hepatitis C virus density changed with removal of the viral envelope by lipid solvents. Thus the buoyant density of hepatitis C virus in sucrose was 1.08 to 1.11 gm/ml for an intact virion and 1.22 to 1.25 gm/ml for what was presumed to be a nucleocapsid. These results demonstrated that HCV virion is a dominant form in the circulation of blood donors without ALT abnormalities. In patients with liver inflammation HCV particles with higher densities of 1.22 to 1.25 gm/ml coexist with virion in the circulation, which might be presumed nucleocapsids. (Hepatology 1994;19:296-302).
DEA physician registration numbers: a need to know
Authors: J. R. Cooper
Journal: JAMA (1994)

<h3>In Reply.</h3> —The concerns expressed by Dr Cooper regarding the inappropriate use of DEA registration numbers are legitimate. In many respects, his letter echoes the DEA's long-stated policy regarding this problem. The insurance industry's policy of requiring the prescriber's DEA registration number as a condition for reimbursement is irresponsible. A significant portion of controlled substance diversion occurs through fraudulent prescriptions. Demanding that DEA numbers be furnished with all prescriptions, most of which do not otherwise require them, greatly increases the opportunities for misuse of DEA numbers. Despite the reservations expressed by the DEA, practitioners, pharmacists, and insurance firms continue the policy. They state, variously, that the DEA number is the only universal identifier available; there is no evidence that the requirement has increased diversion; or there is no law that prohibits the practice. This inappropriate use of DEA registration numbers has compromised the closed system of distribution. The insurance industry