tbuckley/cabot-search huggingface dataset:
Differential antagonism of cardiac actions of adenosine by theophylline
Authors: B. D. Bertolet, L. Belardinelli, K. Avasarala, W.B. Calhoun, E. A. Franco, W. W. Nichols, R. A. Kerensky, J. A. Hill
Journal: Cardiovascular Research (1996)

To determine the relative sensitivity of cardiac A1- and A2-adenosine receptor-mediated effects to antagonism by theophylline in man. Methods: Baseline measurements of the A-H interval (A1-adenosine receptor-mediated effect) and coronary blood flow (A2-adenosine receptor-mediated effect) were made in 10 patients with angiographically normal coronary arteries. Adenosine was then administered as a continuous intravenous infusion followed by a rapid intravenous bolus, and measurements repeated. Theophylline (5 mg/kg i.v.) was then administered, and the adenosine infusion repeated. To corroborate the results found in man, the cardiac A1- and A2-adenosine receptor-mediated effects were measured in guinea pig isolated hearts exposed to increasing concentrations of adenosine, in the absence and presence of theophylline (60 μM). Results: Compared to baseline, adenosine infusion and bolus caused significant prolongation of the A-H interval (109 ± 41 vs. 116 ± 44 vs. 168 ± 57 ms, respectively), and increase in coronary blood flow (46 ± 37 vs. 86 ± 71 vs. 172 ± 98 ml/min, respectively). Theophylline abolished the prolongation of the A-H interval during adenosine infusion and bolus (99 ± 36 and 107 ± 44 ms, respectively), yet had minimal effect on the increase in coronary blood flow (63 ± 51 and 136 ± 121 ml/min, respectively). In guinea pig isolated hearts, theophylline was shown to significantly antagonize the A2-adenosine receptor-mediated effects only when the concentrations of adenosine were ≤ 1.0 μM. Conclusions: In man, theophylline completely antagonizes the A1-adenosine receptor-mediated prolongation of the A-H interval, but has minimal effect on the A2-receptor-mediated coronary vasodilation, particularly when adenosine concentrations exceed 1.0 μM.
Psychology and Psychotherapy
Journal: JAMA (1934)

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The Initiation of Male Homosexual Behavior
Authors: Harry W. Haverkos
Journal: JAMA (1989)

<h3>To the Editor. —</h3> The Surgeon General of the Public Health Service has proclaimed that education about acquired immunodeficiency syndrome (AIDS) should start in early elementary school and must include information on heterosexual and homosexual relationships.<sup>1</sup>However, to develop an age-appropriate and "informed" education program, more research is needed regarding the initiation of both heterosexual and homosexual behavior and concomitant social and psychological circumstances. Although there is some information in the literature concerning onset of heterosexual behavior among teenage boys and girls and the onset of intravenous drug abuse, there is less information on the initiation of male homosexual behavior.<sup>2</sup>Remafedi<sup>3</sup>indicates that the prevalence of homosexual activity to orgasm among adolescents ranges from 17% to 37% across four separate surveys of young male adults. Reviewing data collected by the Centers for Disease Control early in the AIDS epidemic provides relevant information on the initiation of homosexual
THE C3-ACTIVATOR SYSTEM: AN ALTERNATE PATHWAY OF COMPLEMENT ACTIVATION
Authors: Otto Götze, Hans J. Müller-Eberhard
Journal: The Journal of Experimental Medicine (1971)

Evidence has accumulated indicating the existence of a second complement activation mechanism which is functionally analogous to C1, C2, and C4. The noncomplement protein C3PA, previously recognized through its ability to form a complex enzyme with a protein from cobra venom, appears to be the precursor of the C4,2 analogue. It is a thermolabile ß-globulin with a molecular weight of 80,000. When serum is treated with naturally occurring plant or bacterial polysaccharides, the C3PA is cleaved into at least two fragments, one having the electrophoretic mobility of a γ-globulin and a molecular weight of 60,000, and the other being an acidic peptide with a molecular weight of 20,000. The larger fragment has the ability to cleave C3 into C3a and C3b and is therefore called C3 activator. It arises from the action of an as yet unidentified serum enzyme upon the C3PA, which is tentatively called C3PA convertase. In addition to endotoxins, yeast cell walls, inulin, and agar, aggregates of immunoglobulins were found to be activating substances, including human IgA, guinea pig γ1, and duck antibody. Serum depleted of C3PA had reduced E. coli bactericidal and increased hemolytic activity. The relationship of the C3-activator system to experimental and clinical observations has been discussed.
Influenza: Essays by Several Authors.
Journal: JAMA (1922)

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Demonstration of Focal Brain Ischemia Induced by Hyperventilation Using Tc-99m HMPAO SPECT
Authors: HITOSHI TERADA, AKIRA KUWAJIMA, YOSHIHIRO HIRAMATSU, KAZUYA AOKI, SATOSH IWABUCHI, HIROTSUGU SAMEJIMA, NOBUO YOSHII, HIROSHI MATSUDA
Journal: Clinical Nuclear Medicine (1993)

A case with vasospasm of the right anterior cerebral artery induced by hyperventilation is presented. Consecutive Tc-99m HMPAO brain SPECT studies at rest and during hyperventilation greatly contributed to the quantitative evaluation of focal perfusion decrease in conjunction with contrast angiography. This technique seems to be useful for the detection of alterations in regional brain perfusion during short duration intervention.
A Hard-Shell Temperature-Controlling Disposable Blood Oxygenator
Authors: Richard A. DeWall
Journal: JAMA (1966)

A new blood oxygenator which comes presterilized and assembled has been used in open-heart surgery. Cooling and rewarming of the patient is efficiently maintained. Blood-flow rates exceeding 5 liters/min are easily managed by the oxygenator with an oxygenating gas to blood ratio of 2:1 to 4:1. The oxygenator functions with varying priming volumes as determined by the patient's size. Total priming of the apparatus is achieved with water electrolyte solutions. Successful clinical perfusions have lasted over 3 1/2 hours with every indication that appreciably longer perfusions would be possible. Perfusions with this apparatus are capable of maintaining normal metabolic states for prolonged periods. The total inhospital blood utilization including operating room and postoperative needs by these patients has averaged 4 liters.
When Health Physics Was the New Kid on the Block
Authors: J. Newell Stannard
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Особливості лікування бронхіальної астми в поєднанні з гастроезофагеальною рефлюксною хворобою
Authors: I.O. Borovyk, L.S. Babinets, S.Ye. Shostak, S.S. Ryabokon, N.Ye. Botsyuk
Journal: GASTROENTEROLOGY (2014)

Досліджували поєднаний перебіг бронхіальної астми й гастроезофагеальної рефлюксної хвороби. Визначали ефективність антисекреторної терапії в комплексному лікуванні хворих із поєднаною патологією. Встановлено, що включення в лікувальну програму інгібітору протонної помпи рабепразолу суттєво покращує показники зовнішнього дихання та якість життя пацієнтів із бронхіальною астмою.
Children's Radiographic Technic
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypocalcemia in Critical Illness
Authors: Gary Paul Zaloga
Journal: JAMA (1986)

CALCIUM is an essential ion required for many biologic processes, including neuronal conduction, synaptic transmission, hormone secretion, mitotic division, cardiac automaticity, and excitation-contraction coupling in muscle. Calcium is also a major intracellular messenger, is needed for cellular processes that require movement, and is required by many enzymes for full activity. Deficiency of circulating concentrations of this important ion are common in patients with critical illness. <h3>Physiologic Regulation of the Serum Calcium Concentration</h3> The serum calcium concentration is maintained within normal limits by the combined effects of parathyroid hormone (PTH) and vitamin D. Dietary calcium is not required, since these hormones can maintain the serum calcium level via their skeletal effects. A deficiency in either hormone, however, may lead to hypocalcemia. Deficiency in PTH may result from parathyroid gland damage, as may occur after neck surgery, or from parathyroid gland suppression. The parathyroid glands may be suppressed by hypercalcemia, hypomagnesemia, or
Страницы жизни лейб-медика семьи николая II Владимира Николаевича Деревенко
Authors: Shevtsova Z.I. Shevtsova Z.I., V.V. Gaponov
Journal: GASTROENTEROLOGY (2013)

В статье представлены этапы жизненного пути и многолетней профессиональной деятельности ученого, профессора, хирурга, гражданина Владимира Деревенко. Ему пришлось пройти через лишения, ссылки, аресты. Причина преследований — шестилетняя работа по оказанию медицинской помощи царской семье, в частности наследнику престола Алексею.
Visceral Innervation and Its Relation to Personality
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights of This Issue
Journal: Clinical Cancer Research (2013)

Vrignaud and colleagues present a comprehensive overview of preclinical studies with cabazitaxel, a semisynthetic taxane that has been shown to overcome docetaxel resistance, with proof-of-concept achieved in clinical studies. These findings support the current use of this agent in patients with metastatic hormone-refractory prostate cancer experiencing disease progression following docetaxel therapy and offer an insight into a successful development process for a new anticancer agent, highlighting the importance of conducting relevant, rationally designed studies to accelerate progress in drug discovery.Clinical studies estimate that 40% to 70% of survivors given chemotherapy-only treatment experience neurocognitive impairment. Cancer chemotherapeutics have been examined in preclinical models of learning in adult rodents; however, these models are not adequate for studying emergent effects of childhood treatment. To examine these effects using young rodents, Bisen-Hersh and colleagues treated mouse pups on postnatal days 14 to 16 with methotrexate and cytarabine. Nineteen days after treatment, impairment on one-trial learning tasks was found, but only mild deficits occurred on an extensive training task, suggesting that practice may ameliorate deficits. These findings have implications for the development of cognitive remediation programs for childhood cancer survivors.Salivary gland tumors constitute 0.3% of all human tumors and ∼4% of head and neck cancer, with 37 subtypes, many having overlapping histopathology, presenting clinical and diagnostic challenges. Extracellular RNA is an emerging target for biomarker development. Matse and colleagues explore the utility of salivary extracellular microRNA to discriminate malignant from benign parotid gland tumors, where 80% of salivary gland tumors occur. Six salivary extracellular microRNAs were statistically different between the 2 groups. The best combination of 4 biomarkers yielded a receiver-operating characteristics curve with an area under the curve of 90%, a sensitivity of 69%, and a specificity of 95% in discriminating saliva samples from patients with malignant tumors from those in patients with benign tumors in the parotid gland. These results are promising for the development of noninvasive tools for early detection of tumors in salivary glands.Vismodegib is an orally bioavailable small-molecule Smoothened inhibitor that is currently available for the treatment of advanced basal cell carcinoma. To explore the effects of food on plasma exposure of this drug, Sharma and colleagues designed and conducted a pharmacokinetic study in patients with advanced solid tumors. They found no significant differences in exposure at steady state after daily dosing between patients who took the drug fasting versus fed. Vismodegib can be safely taken with or without food, and the study design used here can serve as a template for studies of other oral anticancer drugs.
A Text-Book of Physiology: For Medical Students and Physicians.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epistaxis in a Teen-Age Boy
Authors: Sidney P. Kadish
Journal: JAMA (1971)

Dr. Robert F. Rider: Two years before the present admission, this 13-year-old boy was seen in the Massachusetts Eye and Ear Infirmary emergency ward for uncontrollable bleeding from the nose. The right posterior naris was cauterized, but the patient returned on the following morning with fresh bleeding. He was admitted, and a pack was introduced into the right posterior nasal cavity. The blood pressure on admission was 144 mm Hg systolic and 95 mm Hg diastolic. Two days later the pack was removed, revealing a bleeding mass in the right posterior nasal cavity arising from the nasopharynx. After biopsy, the mass was treated with cryosurgery via a transpalatine approach. Postoperatively, the patient did well until two months before the present admission, when a recurrent nasopharyngeal mass and fullness of the right side of the face were noted on a routine clinic visit. Roentgenograms of the paranasal sinuses were obtained. <h3>Discussion</h3>
Possible Diphenylhydantoin-Induced Arrhythmia in Hypothyroidism
Authors: Milford Fulop
Journal: JAMA (1966)

WE HAVE RECENTLY seen a patient with hypothyroidism and heart disease who developed supraventricular tachycardia following the administration of diphenylhydantoin. The use of this drug for treatment of cardiac arrhythmias has received favorable attention<sup>1,2</sup>and so the circumstances in this case are of interest. <h3>Report of a Case</h3> A 53-year-old white woman with rheumatic heart disease had a mitral commissurotomy in 1954. Although euthyroid, she was given an ablative dose of sodium iodide 1131 in 1955 in an effort to slow her heart rate. With the development of symptomatic hypothyroidism, she was given thyroid replacement therapy. She took sodium levothyroxine (Synthroid) (0.15 mg) daily and quinidine sulfate (0.3 gm) three times a day during the year before the present hospitalization, and digoxin (0.25 mg) daily during the preceding month. She was hospitalized in May 1965 because of the renewed appearance of atrial flutter with 2:1 to 4:1 atrioventricular (AV)
From the Health Care Financing Administration
Authors: L. B. Hays
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metastatic Renal Cell Carcinoma Long After Nephrectomy
Authors: Stephen H. Miller
Journal: JAMA (1977)

<h3>To the Editor.—</h3> I read the recent article by Donaldson et al entitled "Metastatic Renal Cell Carcinoma 24 Years After Nephrectomy" (236:950, 1976). We recently reported the case of a 70-year-old woman with metastatic renal cell carcinoma to the middle nasal turbinate in the<i>Journal of Surgical Oncology</i>(8:183-190, 1976). This same patient had had a right nephrectomy performed for renal cell carcinoma 20 years prior and multiple bilateral pulmonary metastasis noted on chest x-ray films for the past six years. The patient underwent radiation therapy to the right middle turbinate region; this area had been biopsied and the specimen was found to contain metastatic hypernephroma. She has had good response to this treatment for at least two years and continues to survive. I do hope that this will add to the report by Donaldson and colleagues.