tbuckley/cabot-search huggingface dataset:
Association Between Use of Angiotensin Receptor Blockers and Incidence of Epilepsy in Patients With Hypertension
Authors: Rachel Ryu, Jonathan Kuo
Journal: JAMA Neurology (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Outcomes After Endovascular Therapy With Procedural Sedation vs General Anesthesia in Patients With Acute Ischemic Stroke
Authors: Russell Chabanne, Thomas Geeraerts, Marc Begard, Baptiste Balança, Francesca Rapido, Vincent Degos, Benoit Tavernier, Serge Molliex, Lionel Velly, Franck Verdonk, Anne-Claire Lukaszewicz, Pierre-François Perrigault, Jean-François Albucher, Christophe Cognard, Adrien Guyot, Charlotte Fernandez, Aurélie Masgrau, Ricardo Moreno, Anna Ferrier, Samir Jaber, Jean-Etienne Bazin, Bruno Pereira, Emmanuel Futier, Kevin Lagarde, Bernard Cosserant, Thibaut Cammas, Julien Pascal, Florian Grimaldi, Erwan Laroche, Camille Boissy, Romain Grobost, Pierre-Antoine Pioche, Jean-Baptiste Joffredo, Audrey Johanny, Denis Savranin, Julien Massardier,, Katia Levrier, Antoine Brandely, Isabelle Langlade, Danielle Saurel, Nicolas Rascol, Mélanie Bailleau, Julie Fayon, Laurent Vallet, Elodie Caumon, Christine Rolhion, Dominique Morand, Julien Amat, Betty Jean, Emmanuel Chabert, Abderahim Zerroug, Jean Gabrillargues, Nathalie Bourgois, Xavier Moisset, Pierre Clavelou, Nicolas Vitello, Maxime Beilvert, Etienne Aldige, Ségolène Mrozek, Francois Delort, Edouard Naboulsi, Elsa Tardif, Elodie Parry, Maxime Pommier, Maud Prezman-Pietri, David Rousset, Claire Larcher, Louis Delamarre, Charlotte Martin, Diane Osinski,, Olivier Fourcade, Jean-Marc Olivot, Lionel Calviere, Nicolas Raposo, Alain Viguier, Fabrice Bonneville, Anne-Christine Januel, Philippe Tall, Caterina Michelozzi, Jean Darcourt, Lionel Bapteste, Anisoara Gemanar, Catherine Mottolese, Roxane Silve, Pierre-François Perrigault, Océane Garnier, Jérôme Ridolfo, Mokhtar Bouhaddjar, Julien Fendeleur, Jean Clement Lau, Mélanie Ratié, Vincent Costalat, Federico Cagnazzo, Romain Pasqualotto, Frédéric Clarencon, Grégory Torkomian, Valentine Battisti, Elsa Jozefowicz, Apolline Kazemihru, Hilde Henon, Aurelie Lafanechere, Lois Henry, Julie Bellet, Alexandre Gaudet, Fanny Foltzer, Laurie Parmentier, Clément Magand, Mohamed Aggour, Anaele Pregny, Marlène Bonnefoi, Nicolas Bruder, Camille Vaisse, Michele Bertrandy, Laure Doukhan, Sophie Cataldi, Inal Imane, Valentine Verdier, Didier Sanchez, Jean-Claude Dumont, Souad Fellous, Marc Garnier, Olivier Lavabre, David Bernstein, Violaine Baranger, Elie Thomas, Chrysanthi Papagiannaki, Elisabeth Lenormand, Jean-François Payen, Mathieu Zuber, Nicolas Molinari
Journal: JAMA Neurology (2023)

General anesthesia and procedural sedation are common practice for mechanical thrombectomy in acute ischemic stroke. However, risks and benefits of each strategy are unclear.
Factors Associated With Variability in the Performance of a Proprietary Sepsis Prediction Model Across 9 Networked Hospitals in the US
Authors: Patrick G. Lyons, Mackenzie R. Hofford, Sean C. Yu, Andrew P. Michelson, Philip R. O. Payne, Catherine L. Hough, Karandeep Singh
Journal: JAMA Internal Medicine (2023)

This cohort study uses data from electronic health records to assess variability in a sepsis prediction model across 9 hospitals.
Association Between Estimated Geocoded Residential Maternal Exposure to Lithium in Drinking Water and Risk for Autism Spectrum Disorder in Offspring in Denmark
Authors: Zeyan Liew, Qi Meng, Qi Yan, Jörg Schullehner, Birgitte Hansen, Søren Munch Kristiansen, Denitza D. Voutchkova, Jørn Olsen, Annette Kjær Ersbøll, Matthias Ketzel, Ole Raaschou-Nielsen, Beate R. Ritz
Journal: JAMA Pediatrics (2023)

Lithium is a naturally occurring and trace element that has mood-stabilizing effects. Maternal therapeutic use of lithium has been associated with adverse birth outcomes. In animal models, lithium modulates Wnt/β-catenin signaling that is important for neurodevelopment. It is unknown whether exposure to lithium in drinking water affects brain health in early life.
Frequency of Use and Outcomes of Colonoscopy in Individuals Older Than 75 Years
Authors: Jessica El Halabi, Carol A. Burke, Essa Hariri, Maged Rizk, Carole Macaron, John McMichael, Michael B. Rothberg
Journal: JAMA Internal Medicine (2023)

The benefits from colorectal cancer (CRC) screening may take 10 to 15 years to accrue. Therefore, screening is recommended for older adults who are in good health.
Management of acute diverticulitis with pericolic free gas (ADIFAS): an international multicenter observational study
Authors: Patricia Tejedor, Carlos Pastor, Gianluca Pellino, Salomone Di Saverio, Marguerite Gorter-Stam, Patricia Sylla, Nader Francis
Journal: International Journal of Surgery (2023)

Background: There are no specific recommendations regarding the optimal management of this group of patients. The World Society of Emergency Surgery suggested a nonoperative strategy with antibiotic therapy, but this was a weak recommendation. This study aims to identify the optimal management of patients with acute diverticulitis (AD) presenting with pericolic free air with or without pericolic fluid. Methods: A multicenter, prospective, international study of patients diagnosed with AD and pericolic-free air with or without pericolic free fluid at a computed tomography (CT) scan between May 2020 and June 2021 was included. Patients were excluded if they had intra-abdominal distant free air, an abscess, generalized peritonitis, or less than a 1-year follow-up. The primary outcome was the rate of failure of nonoperative management within the index admission. Secondary outcomes included the rate of failure of nonoperative management within the first year and risk factors for failure. Results: A total of 810 patients were recruited across 69 European and South American centers; 744 patients (92%) were treated nonoperatively, and 66 (8%) underwent immediate surgery. Baseline characteristics were similar between groups. Hinchey II–IV on diagnostic imaging was the only independent risk factor for surgical intervention during index admission (odds ratios: 12.5, 95% CI: 2.4–64, P =0.003). Among patients treated nonoperatively, at index admission, 697 (94%) patients were discharged without any complications, 35 (4.7%) required emergency surgery, and 12 (1.6%) percutaneous drainage. Free pericolic fluid on CT scan was associated with a higher risk of failure of nonoperative management (odds ratios: 4.9, 95% CI: 1.2–19.9, P =0.023), with 88% of success compared to 96% without free fluid ( P &lt;0.001). The rate of treatment failure with nonoperative management during the first year of follow-up was 16.5%. Conclusion: Patients with AD presenting with pericolic free gas can be successfully managed nonoperatively in the vast majority of cases. Patients with both free pericolic gas and free pericolic fluid on a CT scan are at a higher risk of failing nonoperative management and require closer observation.
Laboratory biomarker as an alternative to low-dose computed tomography for the diagnosis of suspected appendicitis? Circulating fibrocyte percentage and neutrophil–lymphocyte ratio are accurate biomarkers of uncomplicated and complicated appendicitis: a prospective cohort study
Authors: Rui Zhang, Zhe-Ming Zhao, Chun-Dong Zhang
Journal: International Journal of Surgery (2023)

aDepartment of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang 110801, China bDepartment of Gastrointestinal Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China Rui Zhang, Zhe-Ming Zhao: These authors contributed equally as co-first author. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital, China Medical University, No.4 Chongshan East Road, Shenyang 110032, China. Tel: +86-189-0091-2404. Fax: +86-24-6204-3110. E-mail address: [email protected] (C-D. Zhang). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Glycine and aging: Evidence and mechanisms
Authors: Adiv A. Johnson, Trinna L. Cuellar
Journal: Ageing Research Reviews (2023)

The restriction of calories, branched-chain amino acids, and methionine have all been shown to extend lifespan in model organisms. Recently, glycine was found to boost longevity in genetically heterogenous mice. This simple amino acid similarly extends lifespan in rats and improves health in mammalian models of age-related disease. While compelling data indicate that glycine is a pro-longevity molecule, divergent mechanisms may underlie its effects on aging. Glycine is abundant in collagen, a building block for glutathione, a precursor to creatine, and an acceptor for the enzyme glycine N-methyltransferase (GNMT). A review of the literature strongly implicates GNMT, which clears methionine from the body by taking a methyl group from S-adenosyl-L-methionine and methylating glycine to form sarcosine. In flies, Gnmt is required for reduced insulin/insulin-like growth factor 1 signaling and dietary restriction to fully extend lifespan. The geroprotector spermidine requires Gnmt to upregulate autophagy genes and boost longevity. Moreover, the overexpression of Gnmt is sufficient to extend lifespan and reduce methionine levels. Sarcosine, or methylglycine, declines with age in multiple species and is capable of inducing autophagy both in vitro and in vivo. Taken all together, existing evidence suggests that glycine prolongs life by mimicking methionine restriction and activating autophagy.
Multicenter, prospective, phase 2 study of maintenance bevacizumab for children and adults with <i>NF2</i>-related schwannomatosis and progressive vestibular schwannoma
Authors: Scott R Plotkin, Jeffrey Allen, Girish Dhall, Jian L Campian, D Wade Clapp, Michael J Fisher, Rakesh K Jain, James Tonsgard, Nicole J Ullrich, Coretta Thomas, Lloyd J Edwards, Bruce Korf, Roger Packer, Matthias A Karajannis, Jaishri O Blakeley
Journal: Neuro-Oncology (2023)

Abstract Background Prospective data on maintenance therapy with bevacizumab for persons with NF2-related schwannomatosis (NF2-SWN) is lacking. In this prospective multicenter phase II study, we evaluated the efficacy, safety, and tolerability of bevacizumab for maintenance therapy in children and adults with NF2-SWN and hearing loss due to vestibular schwannomas (VS). Methods Following induction therapy, participants received bevacizumab 5 mg/kg every 3 weeks for 18 months. Participants were monitored for changes in hearing, tumor size, and quality of life (QOL), and for adverse events. Hearing loss was defined as a statistically significant decline in word recognition score (WRS) or pure-tone average compared to the study baseline; tumor growth was defined as &amp;gt;20% increase in volume compared to baseline. Results Twenty participants with NF2-SWN (median age 23.5 years; range, 12.5–62.5 years) with hearing loss in the target ear (median WRS 70%, range 2%–94%) received maintenance bevacizumab. Freedom from hearing loss in the target ear was 95% after 48 weeks, 89% after 72 weeks, and 70% after 98 weeks. Freedom from tumor growth in the target VS was 94% after 48 weeks, 89% after 72 weeks, and 89% after 98 weeks. NF2-related QOL remained stable for 98 weeks whereas tinnitus-related distress decreased. Maintenance bevacizumab was well tolerated, with 3 participants (15%) discontinuing treatment due to adverse events. Conclusions Maintenance bevacizumab (5 mg/kg every 3 weeks) is associated with high rates of hearing and tumor stability during 18 months of follow-up. No new unexpected adverse events related to bevacizumab were identified in this population.
Consider R Codes for Undiagnosed Serious Pediatric Behavior Problems—Reply
Authors: Anna M. Cushing, Kenneth A. Michelson, Pradip P. Chaudhari
Journal: JAMA Pediatrics (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Human visual explanations mitigate bias in AI-based assessment of surgeon skills
Authors: Dani Kiyasseh, Jasper Laca, Taseen F. Haque, Maxwell Otiato, Brian J. Miles, Christian Wagner, Daniel A. Donoho, Quoc-Dien Trinh, Animashree Anandkumar, Andrew J. Hung
Journal: npj Digital Medicine (2023)

Artificial intelligence (AI) systems can now reliably assess surgeon skills through videos of intraoperative surgical activity. With such systems informing future high-stakes decisions such as whether to credential surgeons and grant them the privilege to operate on patients, it is critical that they treat all surgeons fairly. However, it remains an open question whether surgical AI systems exhibit bias against surgeon sub-cohorts, and, if so, whether such bias can be mitigated. Here, we examine and mitigate the bias exhibited by a family of surgical AI systems-SAIS-deployed on videos of robotic surgeries from three geographically-diverse hospitals (USA and EU). We show that SAIS exhibits an underskilling bias, erroneously downgrading surgical performance, and an overskilling bias, erroneously upgrading surgical performance, at different rates across surgeon sub-cohorts. To mitigate such bias, we leverage a strategy -TWIX-which teaches an AI system to provide a visual explanation for its skill assessment that otherwise would have been provided by human experts. We show that whereas baseline strategies inconsistently mitigate algorithmic bias, TWIX can effectively mitigate the underskilling and overskilling bias while simultaneously improving the performance of these AI systems across hospitals. We discovered that these findings carry over to the training environment where we assess medical students' skills today. Our study is a critical prerequisite to the eventual implementation of AI-augmented global surgeon credentialing programs, ensuring that all surgeons are treated fairly.
Development of a difficulty scoring system for laparoscopic pancreatoduodenectomy in the initial stage of the learning curve: a retrospective cohort study
Authors: Feng Peng, Ruizhi He, Hebin Wang, Hang Zhang, Min Wang, Tingting Qin, Renyi Qin
Journal: International Journal of Surgery (2023)

It remains uncertain how surgeons can safely pass the learning curve of laparoscopic pancreatoduodenectomy (LPD) without potentially harming patients. We aimed to develop a difficulty scoring system (DSS) to select an appropriate patient for surgeons.A total of 773 elective pancreatoduodenectomy surgeries between July 2014 and December 2019, including 346 LPD and 427 open pancreatoduodenectomy cases, were included. A 10-level DSS for LPD was developed, and an additional 77 consecutive LPD surgeries which could provide information of the learning stage I of LPD externally validated its performance between December 2019 and December 2021.The incidences of postoperative complications (Clavien-Dindo≥III) gradually decreased from the learning curve stage I-III (20.00, 10.94, 5.79%, P =0.008, respectively). The DSS consisted of the following independent risk factors: (1) tumor location, (2) vascular resection and reconstruction, (3) learning curve stage, (4) prognostic nutritional index, (5) tumor size, and (6) benign or malignant tumor. The weighted Cohen's κ statistic of concordance between the reviewer's and calculated difficulty score index was 0.873. The C -statistics of DSS for postoperative complication (Clavien-Dindo≥III) were 0.818 in the learning curve stage I. The patients with DSS<5 had lower postoperative complications (Clavien-Dindo≥III) than those with DSS≥5 (4.35-41.18%, P =0.004) in the training cohort and had a lower postoperative pancreatic fistula (19.23-57.14%, P =0.0352), delayed gastric emptying (19.23-71.43%, P =0.001), and bile leakage rate (0.00-21.43%, P =0.0368) in validation cohort in the learning curve stage I.We developed and validated a difficulty score model for patient selection, which could facilitate the stepwise adoption of LPD for surgeons at different stages of the learning curve.
Safety and longevity of biological treatment in the setting of moderate-to-severe psoriasis: enhancing the body of evidence
Authors: Lynda Spelman
Journal: British Journal of Dermatology (2023)

Journal Article Safety and longevity of biological treatment in the setting of moderate-to-severe psoriasis: enhancing the body of evidence Get access Lynda Spelman Lynda Spelman Queensland Institute of Dermatology, Brisbane, QLD, Australia Correspondence: Lynda Spelman. Email: lspelman@qiderm.com.au Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 188, Issue 6, June 2023, Page 696, https://doi.org/10.1093/bjd/ljad112 Published: 03 April 2023 Article history Accepted: 17 March 2023 Received: 29 March 2023 Published: 03 April 2023 Corrected and typeset: 10 May 2023
Hypoxia and Cardiac Function in Patients With Prior Myocardial Infarction
Authors: Jan-Niklas Hönemann, Darius Gerlach, Fabian Hoffmann, Tilmann Kramer, Henning Weis, Christine E. Hellweg, Bikash Konda, Vlad G. Zaha, Hesham A. Sadek, Antonius E. van Herwarden, André J. Olthaar, Hannes Reuter, Stephan Baldus, Benjamin D. Levine, Jens Jordan, Jens Tank, Ulrich Limper
Journal: Circulation Research (2023)
Consider R Codes for Undiagnosed Serious Pediatric Behavior Problems
Authors: Gabrielle A. Carlson, Wilfred Farquharson, Jon M. McClellan
Journal: JAMA Pediatrics (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Argumentation in end-of-life conversations with families in Dutch intensive care units: a qualitative observational study
Authors: Aranka Akkermans, Sanne Prins, Amber S. Spijkers, Jean Wagemans, Nanon H. M. Labrie, Dick L. Willems, Marcus J. Schultz, Thomas G. V. Cherpanath, Job B. M. van Woensel, Marc van Heerde, Anton H. van Kaam, Moniek van de Loo, Anne Stiggelbout, Ellen M. A. Smets, Mirjam A. de Vos
Journal: Intensive Care Medicine (2023)

In intensive care units (ICUs), decisions about the continuation or discontinuation of life-sustaining treatment (LST) are made on a daily basis. Professional guidelines recommend an open exchange of standpoints and underlying arguments between doctors and families to arrive at the most appropriate decision. Yet, it is still largely unknown how doctors and families argue in real-life conversations. This study aimed to (1) identify which arguments doctors and families use in support of standpoints to continue or discontinue LST, (2) investigate how doctors and families structure their arguments, and (3) explore how their argumentative practices unfold during conversations. A qualitative inductive thematic analysis of 101 audio-recorded conversations between doctors and families. Seventy-one doctors and the families of 36 patients from the neonatal, pediatric, and adult ICU (respectively, N-ICU, P-ICU, and A-ICU) of a large university-based hospital participated. In almost all conversations, doctors were the first to argue and families followed, thereby either countering the doctor's line of argumentation or substantiating it. Arguments put forward by doctors and families fell under one of ten main types. The types of arguments presented by families largely overlapped with those presented by doctors. A real exchange of arguments occurred in a minority of conversations and was generally quite brief in the sense that not all possible arguments were presented and then discussed together. This study offers a detailed insight in the argumentation practices of doctors and families, which can help doctors to have a sharper eye for the arguments put forward by doctors and families and to offer room for true deliberation.
Association of Age at Menopause and Hormone Therapy Use With Tau and β-Amyloid Positron Emission Tomography
Authors: Gillian T. Coughlan, Tobey J. Betthauser, Rory Boyle, Rebecca L. Koscik, Hannah M. Klinger, Lori B. Chibnik, Erin M. Jonaitis, Wai-Ying Wendy Yau, Allen Wenzel, Bradley T. Christian, Carey E. Gleason, Ursula G. Saelzler, Michael J. Properzi, Aaron P. Schultz, Bernard J. Hanseeuw, JoAnn E. Manson, Dorene M. Rentz, Keith A. Johnson, Reisa Sperling, Sterling C. Johnson, Rachel F. Buckley
Journal: JAMA Neurology (2023)

Postmenopausal females represent around 70% of all individuals with Alzheimer disease. Previous literature shows elevated levels of tau in cognitively unimpaired postmenopausal females compared with age-matched males, particularly in the setting of high β-amyloid (Aβ). The biological mechanisms associated with higher tau deposition in female individuals remain elusive.