tbuckley/cabot-search huggingface dataset:
Biodiversity modeling advances will improve predictions of nature’s contributions to people
Authors: Jamie M. Kass, Keiichi Fukaya, Wilfried Thuiller, Akira S. Mori
Journal: Trends in Ecology & Evolution (2023)

Accurate predictions of ecosystem functions and nature's contributions to people (NCP) are needed to prioritize environmental protection and restoration in the Anthropocene. However, our ability to predict NCP is undermined by approaches that rely on biophysical variables and ignore those describing biodiversity, which have strong links to NCP. To foster predictive mapping of NCP, we should harness the latest methods in biodiversity modeling. This field advances rapidly, and new techniques with promising applications for predicting NCP are still underutilized. Here, we argue that employing recent advances in biodiversity modeling can enhance the accuracy and scope of NCP maps and predictions. This enhancement will contribute significantly to the achievement of global objectives to preserve NCP, for both the present and an unpredictable future.
Inclusion of functional measures and frailty in the development and evaluation of medicines for older adults
Authors: Michael Denkinger, Wilma Knol, Antonio Cherubini, Anita Simonds, Christos Lionis, Denis Lacombe, Elena Petelos, Mary McCarthy, Patrick Ouvrard, Philip Van Kerrebroeck, Piotr Szymański, Amelia Cupelli, Andrea Laslop, Armin Koch, Bruno Sepodes, Carla Torre, Elina Rönnemaa, Ewa Bałkowiec-Iskra, Maria Teresa Herdeiro, Mário Miguel Rosa, Martine Trauffler, Nikica Mirošević Skvrce, Sabine Mayrhofer, Michael Berntgen, Ivana Silva, Francesca Cerreta
Journal: The Lancet Healthy Longevity (2023)

The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) E7, the guidance for the conduct of clinical trials in people older than age 65 years, dates from 1994. Since then, the inclusion of older people in clinical trials has hardly improved, particularly for the oldest old age group (individuals older than age 75 years), which is the fastest growing demographic bracket in the EU. Even though most medications are taken by this group, relevant endpoints and safety outcomes for this cohort are rarely included and reported, both in clinical trials and regulatory approval documents. To improve the critical appraisal and the regulatory review of medicines taken by frail older adults, eight recommendations are presented and discussed in this Health Policy. These recommendations are brought together from different perspectives and experience of the treatment of older patients. On one side, the perspective of medical practitioners from various clinical disciplines, with their direct experience of clinical decision making; on the other, the perspective of regulators assessing the data submitted in medicine registration dossiers, their relevance to the risk-benefit balance for older patients, and the communication of the findings in the product information. Efforts to improve the participation of older people in clinical trials have been in place for more than a decade, with little success. The recommendations presented here are relevant for stakeholders, authorities, pharmaceutical companies, and researchers alike, as the implementation of these measures is not under the capacity of a single entity. Improving the inclusion of frail older adults requires awareness, focus, and action on the part of those who can effect a much needed change.
Adult Organophosphate and Carbamate Insecticide Exposure and Sperm Concentration: A Systematic Review and Meta-Analysis of the Epidemiological Evidence
Authors: Lauren B. Ellis, Karen Molina, C. Rebecca Robbins, Marlaina Freisthler, Daria Sgargi, Daniele Mandrioli, Melissa J. Perry
Journal: Environmental Health Perspectives (2023)

Evidence of the negative impacts of contemporary use insecticides on sperm concentration has increased over the last few decades; however, meta-analyses on this topic are rare.
Associations of Exposure to Air Pollution during the Male Programming Window and Mini-Puberty with Anogenital Distance and Penile Width at Birth and at 1 Year of Age in the Multicenter U.S. TIDES Cohort
Authors: Emily S. Barrett, Sima Sharghi, Sally W. Thurston, Marissa Sobolewski Terry, Christine T. Loftus, Catherine J. Karr, Ruby H.N. Nguyen, Shanna H. Swan, Sheela Sathyanarayana
Journal: Environmental Health Perspectives (2023)

Ambient air pollution may be a developmental endocrine disruptor. In animal models, gestational and perinatal exposure to diesel exhaust and concentrated particulate matter alters anogenital distance (AGD), a marker of prenatal androgen activity, in both sexes. Little is known in humans.
Potential Policy and Community Implications of Equitable Organic Waste, Compost, and Urban Agricultural Systems in the United States
Authors: Samantha M. Hall, Vidya Tikku, Wendy J. Heiger-Bernays
Journal: Environmental Health Perspectives (2023)

Urban organic waste diverted from landfills for use as compost feedstock may help mitigate and adapt to the effects of our changing climate. Yet, compost produced from urban food and yard waste is often a source of contaminants harmful to human and environmental health. Efforts by multiple municipalities are increasing residential and commercial food and yard waste collection; however, finished, tested compost is typically unavailable to those contributing the waste and whose gardens would benefit.
The emerging tumor microbe microenvironment: From delineation to multidisciplinary approach-based interventions
Authors: Yu Fu, Jia Li, Wenyun Cai, Yulan Huang, Xinlong Liu, Zhongyi Ma, Zhongjie Tang, Xufei Bian, Ji Zheng, Jiayun Jiang, Chong Li
Journal: Acta Pharmaceutica Sinica B (2023)

Intratumoral microbiota has become research hotspots, and emerges as a non-negligent new component of tumor microenvironments (TME), due to its powerful influence on tumor initiation, metastasis, immunosurveillance and prognosis despite in low-biomass. The accumulations of microbes, and their related components and metabolites within tumor tissues, endow TME with additional pluralistic features which are distinct from the conventional one. Therefore, it's definitely necessary to comprehensively delineate the sophisticated landscapes of tumor microbe microenvironment, as well as their functions and related underlying mechanisms. Herein, in this review, we focused on the fields of tumor microbe microenvironment, including the heterogeneity of intratumor microbiota in different types of tumors, the controversial roles of intratumoral microbiota, the basic features of tumor microbe microenvironment (
A 34-gene expression biomarker predicts meningioma outcomes and radiotherapy responses
Authors: David R Raleigh, Matthias Preusser
Journal: Neuro-Oncology (2023)

Journal Article A 34-gene expression biomarker predicts meningioma outcomes and radiotherapy responses Get access David R Raleigh, David R Raleigh Departments of Radiation Oncology, Neurological Surgery, and Pathology, University of California San Francisco, San Francisco, California, USA Corresponding Author: David R. Raleigh, MD, PhD, Departments of Radiation Oncology, Neurological Surgery, and Pathology, University of California San Francisco, Helen Diller Family Cancer Research Building, 1450 3rd Street, HD481, San Francisco, CA 94158, USA (david.raleigh@ucsf.edu) https://orcid.org/0000-0001-9299-8864 Search for other works by this author on: Oxford Academic PubMed Google Scholar Matthias Preusser Matthias Preusser Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria (M.P.) https://orcid.org/0000-0003-3541-2315 Search for other works by this author on: Oxford Academic PubMed Google Scholar Neuro-Oncology, Volume 26, Issue 2, February 2024, Pages 207–208, https://doi.org/10.1093/neuonc/noad212 Published: 15 November 2023 Article history Corrected and typeset: 15 November 2023 Published: 15 November 2023
Concerns over informed consent for pregnant women in Pfizer’s RSV vaccine trial
Authors: Hristio Boytchev
Journal: BMJ (2023)

Some experts have criticised Pfizer for not informing pregnant women in its trial of maternal respiratory syncytial virus vaccine that trials of a similar vaccine were halted over a potential risk of preterm birth. Others think that notification would have been premature and caused unnecessary anxiety. <b>Hristio Boytchev</b> reports
Effectiveness of primary care psychological therapy services for treating depression and anxiety in autistic adults in England: a retrospective, matched, observational cohort study of national health-care records
Authors: Céline El Baou, Georgia Bell, Rob Saunders, Joshua E J Buckman, William Mandy, Dave Dagnan, Elizabeth O'Nions, Richard Pender, Henry Clements, Stephen Pilling, Marcus Richards, Amber John, Joshua Stott
Journal: The Lancet Psychiatry (2023)

Autistic adults report a higher prevalence of anxiety and depression than adults without identified autism but have poorer access to appropriate mental health care. Evidence-based psychological therapies are recommended in treatment guidelines for autistic adults, but no study has investigated their effectiveness in large samples representative of the autistic population accessing routine care. This study aimed to examine therapy outcomes for autistic adults in a primary care service.
Prevalence of chronic pain or analgesic use in children and young people and its long-term impact on substance misuse, mental illness, and prescription opioid use: a retrospective longitudinal cohort study
Authors: Andrew Lambarth, Michail Katsoulis, Chengsheng Ju, Alasdair Warwick, Rohan Takhar, Caroline Dale, David Prieto-Merino, Andrew Morris, Debajit Sen, Li Wei, Reecha Sofat
Journal: The Lancet Regional Health - Europe (2023)

Epidemiological studies suggest chronic and recurrent pain affects around a quarter of children, while 8% report intense and frequent pain. The long-term implications of chronic pain in childhood are uncertain. Using electronic health records (EHRs) we used both disease codes and medicines prescription records to investigate the scale of chronic pain and long-term analgesic use in children and young people (CYP), and if chronic pain and/or use of analgesic medicines at an early age is associated with substance misuse, use of prescription opioids, and poor mental health in adulthood.
Safety and efficacy of the intranasal spray SARS-CoV-2 vaccine dNS1-RBD: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial
Authors: Fengcai Zhu, Shoujie Huang, Xiaohui Liu, Qi Chen, Chunlan Zhuang, Hui Zhao, Jinle Han, Anjuli May Jaen, Thai Hung Do, Jonathan Grant Peter, Alexander Gonzalez Dorado, Louie S Tirador, Gelza Mae A Zabat, Ralph Elvi M Villalobos, Gemalyn Pineda Gueco, Lauren Livia Greta Botha, Shirley Patricia Iglesias Pertuz, Jiaxiang Tan, Kongxin Zhu, Jiali Quan, Hongyan Lin, Yue Huang, Jizong Jia, Xiafei Chu, Junyu Chen, Yixin Chen, Tianying Zhang, Yingying Su, Changgui Li, Xiangzhong Ye, Ting Wu, Jun Zhang, Ningshao Xia
Journal: The Lancet Respiratory Medicine (2023)

The live-attenuated influenza virus vector-based intranasal SARS-CoV-2 vaccine (dNS1-RBD, Pneucolin; Beijing Wantai Biological Pharmacy Enterprise, Beijing, China) confers long-lasting and broad protection in animal models and is, to our knowledge, the first COVID-19 mucosal vaccine to enter into human trials, but its efficacy is still unknown. We aimed to assess the safety and efficacy (but not the immunogenicity) of dNS1-RBD against COVID-19.
Effect of a Personalized Tobacco Treatment Intervention on Smoking Abstinence in Individuals Eligible for Lung Cancer Screening
Authors: Brenda Cartmel, Lisa M. Fucito, Krysten W. Bold, Susan Neveu, Fangyong Li, Alana M. Rojewski, Ralitza Gueorguieva, Stephanie S. O’Malley, Roy S. Herbst, Benjamin A. Toll
Journal: Journal of Thoracic Oncology (2023)
AAV-mediated hepatic LPL expression ameliorates severe hypertriglyceridemia and acute pancreatitis in Gpihbp1 deficient mice and rats
Authors: Chenchen Yuan, Yao Xu, Guotao Lu, Yuepeng Hu, Wenjian Mao, Lu Ke, Zhihui Tong, Yan Xia, Sisi Ma, Xiaoyan Dong, Xunde Xian, Xiaobing Wu, George Liu, Baiqiang Li, Weiqin Li
Journal: Molecular Therapy (2023)

GPIHBP1 plays an important role in the hydrolysis of triglyceride (TG) lipoproteins by lipoprotein lipases (LPLs). However, Gpihbp1 knockout mice did not develop hypertriglyceridemia (HTG) during the suckling period but developed severe HTG after weaning on a chow diet. It has been postulated that LPL expression in the liver of suckling mice may be involved. To determine whether hepatic LPL expression could correct severe HTG in Gpihbp1 deficiency, liver-targeted LPL expression was achieved via intravenous administration of the adeno-associated virus (AAV)-human LPL gene, and the effects of AAV-LPL on HTG and HTG-related acute pancreatitis (HTG-AP) were observed. Suckling Gpihbp1−/− mice with high hepatic LPL expression did not develop HTG, whereas Gpihbp1−/− rat pups without hepatic LPL expression developed severe HTG. AAV-mediated liver-targeted LPL expression dose-dependently decreased plasma TG levels in Gpihbp1−/− mice and rats, increased post-heparin plasma LPL mass and activity, decreased mortality in Gpihbp1−/− rat pups, and reduced the susceptibility and severity of both Gpihbp1−/− animals to HTG-AP. However, the muscle expression of AAV-LPL had no significant effect on HTG. Targeted expression of LPL in the liver showed no obvious adverse reactions. Thus, liver-targeted LPL expression may be a new therapeutic approach for HTG-AP caused by GPIHBP1 deficiency. GPIHBP1 plays an important role in the hydrolysis of triglyceride (TG) lipoproteins by lipoprotein lipases (LPLs). However, Gpihbp1 knockout mice did not develop hypertriglyceridemia (HTG) during the suckling period but developed severe HTG after weaning on a chow diet. It has been postulated that LPL expression in the liver of suckling mice may be involved. To determine whether hepatic LPL expression could correct severe HTG in Gpihbp1 deficiency, liver-targeted LPL expression was achieved via intravenous administration of the adeno-associated virus (AAV)-human LPL gene, and the effects of AAV-LPL on HTG and HTG-related acute pancreatitis (HTG-AP) were observed. Suckling Gpihbp1−/− mice with high hepatic LPL expression did not develop HTG, whereas Gpihbp1−/− rat pups without hepatic LPL expression developed severe HTG. AAV-mediated liver-targeted LPL expression dose-dependently decreased plasma TG levels in Gpihbp1−/− mice and rats, increased post-heparin plasma LPL mass and activity, decreased mortality in Gpihbp1−/− rat pups, and reduced the susceptibility and severity of both Gpihbp1−/− animals to HTG-AP. However, the muscle expression of AAV-LPL had no significant effect on HTG. Targeted expression of LPL in the liver showed no obvious adverse reactions. Thus, liver-targeted LPL expression may be a new therapeutic approach for HTG-AP caused by GPIHBP1 deficiency.
Reply to Jared P. Schober, Robert Wang, and Alexander Kutikov’s Letter to the Editor re: Giuseppe Basile, Giuseppe Fallara, Paolo Verri, et al. The Role of 99mTc-Sestamibi Single-photon Emission Computed Tomography/Computed Tomography in the Diagnostic Pathway for Renal Masses: A Systematic Review and Meta-analysis. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2023.07.013
Authors: Giuseppe Basile, Giuseppe Fallara, Arturo Chiti, Alessandro Larcher, Alberto Breda, Umberto Capitanio
Journal: European Urology (2023)
Re: Giuseppe Basile, Giuseppe Fallara, Paolo Verri, et al. The Role of 99mTc-Sestamibi Single-photon Emission Computed Tomography/Computed Tomography in the Diagnostic Pathway for Renal Masses: A Systematic Review and Meta-analysis. Eur Urol. 2023;85:63–71
Authors: Jared P. Schober, Robert Wang, Alexander Kutikov
Journal: European Urology (2023)
Safety and Reliability of a Robot-assisted Laparoscopic Telesurgery System: Expanding Indications in Urological Surgery
Authors: Ye Wang, Qing Ai, Wuyi Zhao, Yu Gao, Qiming Liu, Taoping Shi, Songliang Du, Baojun Wang, Weijun Fu, Qing Yuan, Bin Jiang, Xin Ma, Hongzhao Li, Xu Zhang
Journal: European Urology (2023)
The wisdom of our mentors: clinical pearls in movement disorders
Authors: Rui Araújo, Conor Fearon, Bettina Balint, Susan Bressman, Jennifer Friedman, H A Jinnah, Marina A J Tijssen, Anthony Lang, Andrew Lees, Tim Lynch, Niall Quinn, Philip Thomson, Marie Vidailhet, Bart P van de Warrenburg, Victor S C Fung, Bastiaan R Bloem
Journal: The Lancet Neurology (2023)
Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve
Authors: Ganesh Parameshwar Bhat, Aurora Maurizio, Alessia Motta, Paola Podini, Santo Diprima, Chiara Malpighi, Ilaria Brambilla, Luis Martins, Aurora Badaloni, Daniela Boselli, Francesca Bianchi, Marta Pellegatta, Marco Genua, Renato Ostuni, Ubaldo Del Carro, Carla Taveggia, Stefano de Pretis, Angelo Quattrini, Dario Bonanomi
Journal: Neuron (2023)
Roland Griffiths: innovative psychedelics researcher
Authors: Joanne Silberner
Journal: BMJ (2023)

at the age of 77, was an American psychopharmacologist widely credited with reviving the study of psychedelic drugs."He was almost the opposite of what I imagined a psychedelic researcher would be like," said Nassim Assefi, who curated a talk Griffiths gave in 2015."He was serious, gentle, and had a straight laced appearance, with a deeply calm, spiritual sense about him."When Griffiths learnt his stage 4 colon cancer was likely to be terminal, he told his mentee David Yaden that Yaden should take his mentor's impending death "as an opportunity to feel
Larger Mediastinal Lymph Nodes Are Associated with Worse Lung Function in Persistent Asthma
Authors: Rory Chan, Chary Duraikannu, Mohamed Jaushal Thouseef, Brian Lipworth
Journal: American Journal of Respiratory and Critical Care Medicine (2023)

"Larger Mediastinal Lymph Nodes Are Associated with Worse Lung Function in Persistent Asthma." American Journal of Respiratory and Critical Care Medicine, 209(3), pp. 331–334
Editor's Choice – John Ingram – December 2023
Journal: British Journal of Dermatology (2023)

Metformin anti-inflammatory effects and immunometabolic reprogramming in hidradenitis suppurativaWhile metformin is unlicensed for hidradenitis suppurativa (HS) it is increasingly used for it's anti-inflammatory and metabolic benefits in HS.Metformin is safe in pregnancy, can provide benefit for concomitant polycystic ovary syndrome and may provide some modest weight loss.However, there is a relative lack of understanding of the mechanisms underpinning its action.In the present study, the authors compared the immune and metabolic profiles of peripheral blood mononuclear cells (PBMCs) of patients with HS taking metformin vs. those not taking metformin.They found that metabolic pathways were dysregulated in the PBMCs of patients with HS, which exhibited reduced inflammatory markers following long-term metformin treatment.In a skin explant model, the authors found that overnight culture with metformin reduced inflammatory cytokines and chemokines and glycolytic genes in biopsies from lesions and inflamed skin tunnels of patients with HS.Using in vitro assays, they found that metformin may induce these changes via the NLR family pyrin domain containing 3 (NLRP3) inflammasome and the AMP-activated protein kinase (AMPK)-mammalian target of rapamycin (mTOR) pathway, which is linked to glycolysis and protein synthesis.
Efficacy of rocatinlimab for moderate-to-severe atopic dermatitis – Authors' reply
Authors: Emma Guttman-Yassky, Eric L Simpson, Kristian Reich, Kenji Kabashima, Ken Igawa, Tetsuya Suzuki, Hirotaka Mano, Takeshi Matsui, Ehsanollah Esfandiari, Masutaka Furue
Journal: The Lancet (2023)
The WHO Mental Health Gap Action Programme for mental, neurological, and substance use conditions: the new and updated guideline recommendations
Authors: Elaine Brohan, Neerja Chowdhary, Tarun Dua, Corrado Barbui, Graham Thornicroft, Dévora Kestel, Amza Ali, Sawitri Assanangkornchai, Henry Brodaty, Vladimir Carli, Rabih El Chammay, Odille Chang, Pamela Y Collins, Pim Cuijpers, Christopher Dowrick, Julian Eaton, Cleusa P Ferri, Sandra Fortes, Michael P Hengartner, Asma Humayun, Nathalie Jette, Petrus J de Vries, Maria Elena Medina-Mora, Pratima Murthy, Dinah Nadera, Charles Newton, Michael Njenga, Olayinka Omigbodun, Afarin Rahimi-Movaghar, Atif Rahman, Palmira Fortunato dos Santos, Shekhar Saxena, Lakshmi Vijayakumar, Huali Wang, Pichayanan Wattanavitukul, Enat Yewnetu, Ken Carswell, Sudipto Chatterjee, Batool Fatima, Alexandra Fleischmann, Brandon Gray, Charlotte Hanlon, Fahmy Hanna, Dzmitry Krupchanka, Aiysha Malik, Mark van Ommeren, Vladimir Poznyak, Katrin Seeher, Chiara Servili, Inka Weissbecker, Florence Baingana, Luis Alfonzo Bello, Andrea Bruni, Ana Carina Jorge Dos Santos Ferreira Borges Bigot, Chencho Dorji, Martin Vandendyck, Ledia Lazeri, Maristela Goldnadel Monteiro, Manju Rani, Khalid Saeed, Renato Oliveira e Souza, Wole Ameyan, Valentina Baltag, Francesco Branca, Bernadette Cappello, Giorgio Cometto, Suraya Dalil, Albis Gabrielli, Benedikt Huttner, Ernesto Jaramillo, Taskeen Khan, Jonathan King, Ruediger Krech, Nathalie Roebbel, Nhan Tran, Yuka Sumi
Journal: The Lancet Psychiatry (2023)
Primate-specific ZNF808 is essential for pancreatic development in humans
Authors: Elisa De Franco, Nick D. L. Owens, Hossam Montaser, Matthew N. Wakeling, Jonna Saarimäki-Vire, Athina Triantou, Hazem Ibrahim, Diego Balboa, Richard C. Caswell, Rachel E. Jennings, Jouni A. Kvist, Matthew B. Johnson, Sachin Muralidharan, Sian Ellard, Caroline F. Wright, Sateesh Maddirevula, Fowzan S. Alkuraya, Wafaa Laimon, Samar S. Hassan, Mohamed A. Abdullah, Anders Fritzberg, Emma Wakeling, Nisha Nathwani, Nancy Elbarbary, Amani Osman, Hessa Alkandari, Abeer alTararwa, Abdelhadi Habeb, Abdulmoein Eid Al-Agha, Ihab Abdulhamed Ahmad, Majida Noori Nasaif Aldulaimi, Ala Ustyol, Hiba Mohammed Amin Binomar, Mohammad Shagrani, Neil A. Hanley, Sarah E. Flanagan, Timo Otonkoski, Andrew T. Hattersley, Michael Imbeault
Journal: Nature Genetics (2023)

Identifying genes linked to extreme phenotypes in humans has the potential to highlight biological processes not shared with all other mammals. Here, we report the identification of homozygous loss-of-function variants in the primate-specific gene ZNF808 as a cause of pancreatic agenesis. ZNF808 is a member of the KRAB zinc finger protein family, a large and rapidly evolving group of epigenetic silencers which target transposable elements. We show that loss of ZNF808 in vitro results in aberrant activation of regulatory potential contained in the primate-specific transposable elements it represses during early pancreas development. This leads to inappropriate specification of cell fate with induction of genes associated with liver identity. Our results highlight the essential role of ZNF808 in pancreatic development in humans and the contribution of primate-specific regions of the human genome to congenital developmental disease.