AB0724 To assess the scleroderma clinical trials consortium damage index (SCTC-DI) in patients with systemic sclerosis in Russian cohort patients.
Authors: O. Ovsyannikova, O. Koneva, L. Garzanova, L. P. Ananyeva, R. Shayakhmetova, O. Desinova, A. Khelkovskaia-Sergeeva, M. Starovoytova
Journal: Annals of the Rheumatic Diseases (2022)

Background Systemic sclerosis (SSc) is a multiorgan disease wherein the pathogenic processes of inflammation, vasculopathy and fibrosis lead to multiple disease manifestations. The course of SSc is often one of progressive damage to multiple organs including the skin, joints, heart, lungs, gastrointestinal tract and kidneys. The scleroderma clinical trials consortium damage index (SCTC-DI): a new instrument to quantify organ damage in systemic sclerosis [1]. Objectives To assess the scleroderma clinical trials consortium damage index (SCTC-DI) in patients with systemic sclerosis in Russian cohort patients. Methods Data from 104 patients with systemic sclerosis (mean age was 51,7±12,5;64% have limited subset of the disease; 88% were female) all fulfilling the ACR criteria for SSc. Functional lung tests, high-resolution CT (HRCT), echocardiography, SSc activity (by the European Scleroderma Study Group (EScSG) activity index), HAQ, SHAQ, the six minute walk test (6MWT), scleroderma clinical trials consortium damage index (SCTC-DI) were evaluated. Other data collected including biological results (high-sensitivity C-reactive protein (hsCRP) and erythrocyte sedimentation rate (ESR). Statistical analysis: descriptive data are presented as means (±SD) or medians (with interquartile range [IQR]) for continuous variables, while categorical variables are expressed as counts and percentages. Univariate comparisons were made with 2-sample t tests. we used the Spearman’s rank-order (Spearman’s p) correlations coefficients. Results A significant positive correlations were found between the SCTC-DI values and HAQ (r=0.31, p=0.003), SHAQ (r=0.28, p=0.0087), and values of EScSG activity index (r=0.31, p=0.0066) accordingly. The SCTC-DI values inversely correlated to values of 6MWT (r=-0.246, p=0.003). Moreover, the SCTC-DI values correlated inversely with forced vital capacity (r=-0.543, p&lt;0.00000), forced expiratory volume in 1s (r=-0.487, p&lt;0.00000) and diffusion capacity for carbon monoxide (r=-0.484, p&lt;0.000001). A significant positive correlations the SCTC-DI values were found with pulmonary arterial pressure (PAP) (r=0.232, p=0.022), but didn’t found any correlation with left ventriculi injection fraction (r=-0.104, p&gt;0.05). Also we didn’t find any correlations the SCTC-DI values with ESR levels and hsCRP levels (r=0.18, p&gt;0.05 and r=0.15, p&gt;0.05). Conclusion the SCTC-DI values correlate with dates of HAQ, SHAQ, EScSG activity index, values of 6MWT pulmonary function tests, supporting their use as measures of SSc severity. References [1] Ferdowsi N, Huq M, et al. Development and validation of the Scleroderma Clinical Trial Consortium Damage index (SCTC-DI): a novel instrument to quantify organ damage in systemic sclerosis. Ann Rheum Dis 2019;0:1–10. doi:10.1136/annrheumdis-2018-214764. Disclosure of Interests None declared