tbuckley/cabot-search huggingface dataset:
Drug-Induced Pulmonary Disease
Authors: OM P. SHARMA
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 April 1973Drug-Induced Pulmonary DiseaseOM P. SHARMA, M.D.OM P. SHARMA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-4-616_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: "The Spectrum of Drug-Induced Pulmonary Disease," by E. C. Rosenow III (Ann Intern Med 77:977-991, 1972), is an excellent article, which serves a long-awaited need for such a review.Recently two more rather widely used, therapeutic agents have been reported to produce pulmonary disease. Rubin, Baume, and Vandenberg (1) have described a 20-year-old man with ulcerative colitis, who while on azathioprine, 100 mg/day, developed fever, dyspnea, and bilateral pulmonary infiltrations on a X-ray film of the chest. Spirometry showed a vital capacity of 1.4 litres (normal, 5.1 litres) and FEV1of 1.2 litres (normal, 4.08 litres). Extensive...References1. RUBINBAUMEVANDENBERG GPR: Azathioprine and acute restrictive lung disease. Aust NZ J Med 3:272-274, 1972 CrossrefGoogle Scholar2. LÖBELMACHTEYELDROR HIM: Pulmonary infiltrates with eosinophilia in an asthmatic patient treated with disodium cromoglycate (letter). Lancet 2:1032, 1972 CrossrefMedlineGoogle Scholar1. MAHONSCOTTANSELL WDG: Hypersensitivity to pituitary snuff with miliary shadowing in the lungs. Thorax 22:13-20, 1967 CrossrefMedlineGoogle Scholar2. HARPERBURRELLLAPP LRN: Allergic alveolitis due to pituitary snuff. Ann Intern Med 73:581-584, 1970 LinkGoogle Scholar1. WILLIAMSKANE MC: Treatment of bronchial asthma with cromolyn. JAMA 209:1881-1883, 1969 CrossrefMedlineGoogle Scholar2. HYDESWARTS JC: Long term prophylaxis of childhood asthma using cromolyn sodium. Ann Allergy 29:483-491, 1971 MedlineGoogle Scholar1. KOCH-WESER J: Antiarrhymatic prophylaxis in ambulatory patients with coronary heart disease. Arch Intern Med 129:763-772, 1972 CrossrefMedlineGoogle Scholar1. Naloxone hydrochloride (Narcan). A new narcotic antagonist. Med Lett Drugs Ther 14:2-3, 1972 MedlineGoogle Scholar1. Marijuana and Health. Second Annual Report to Congress. Washington D.C., U.S. Public Health Service, 1972 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByImmunopathological Mechanisms and Clinical Aspects of Allergic Reactions to DrugsImmunology of Adverse Drug ReactionsEosinophilia and Allergic Reactions to DrugsDrug AllergyDrug Allergy 1 April 1973Volume 78, Issue 4Page: 616-618KeywordsDrugsDyspneaFeversForced expiratory volume in the first second of expirationPulmonary diseasesSpirometryThoraxUlcerative colitis Issue Published: 1 April 1973 PDF DownloadLoading ...
Therapeutic Nonequivalence of Oxytetracycline Capsules
Authors: George W. Brice
Journal: JAMA (1969)

<h3>To the Editor:—</h3> For some time, it has been evident that factors other than those customarily examined enter into the therapeutic usefulness of many drugs. Varley<sup>1</sup>has shown that two chemically equivalent preparations of tolbutamide can differ very significantly in availability to the patient and efficacy of the drug, although both meet official specifications. There are other reports<sup>2,3</sup>on the effect of pharmaceutical factors on drug availability, and Friend<sup>4</sup>points to the necessity of "making sure by measuring patients' blood levels or by adequate therapeutic testing that a drug preparation varying in any way from one performing satisfactorily is also capable of doing what is claimed for it." We have conducted a series of serum level studies on 16 lots of oxytetracycline capsules, labelled 250 mg potency, and distributed by 13 different suppliers. Each of these lots was certified by the Food and Drug Administration and our
Board of Trustees report. Clinical laboratory tests and standards
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tumor Virus Induction and Host Cell Capacity Inactivation: Possible In Vitro Tests for Photosensitizing Chemicals&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1982)

The responses of two in vitro mammalian virus-host cell systems to the photosensitizing chemicals proflavine sulfate and 8-methoxypsoralen (8-MOP) in the presence of light are described. Infectious simian virus 40 (SV40) could be induced from SV40-transformed hamster cells by treatment with proflavine plus visible light or 8-MOP plus near UV radiation. The same photosensitizing treatments inactivated the capacity of monkey cells to support the growth of herpes simplex virus. SV40 induction and inactivation of host cell capacity for herpesvirus growth might be useful as screening systems for testing the photosensitizing potential of chemicals. Advantages and disadvantages associated with each system are discussed.
Possible Relationship Between Glycosphingolipids and the Formation of Metastasis in Certain Human Experimental Tumors&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: Vladimir P. Skipski
 4, Charles O. Gitterman, Jay S. Prendergast, Kathleen Betit Yen, Grace Lee, Silvi Lueli, C. Chester Stock
Journal: JNCI Journal of the National Cancer Institute (1980)

Two tumors, human sarcoma #1 (HS #1) and human epidermoid carcinoma #3 (HEp #3), were cultured on the chorioallantoic membrane of chick embryos. Under experimental conditions, HS #1 does not metastasize, whereas HEp #3 metastasizes extensively to chick embryo lungs and other organs. The glycosphingolipid profiles of these tumors were studied and HEp #3 was found to contain about 2.5-fold less lipid-bound sialic acid per 100 mg of total lipid extracted than did HS #1, due mainly to smaller levels of monosialoganglioside (3.7-fold) and disialoganglioside (3.8-fold) in HEp #3. The total amount of neutral glycosphingolipids was approximately the same in both tumors, but their profiles differed. Treatment of these tumors with 6,7,8,9-tetrahydro-1-mercapto-1 ,2,4-triazolo-[4,3-a]quinazolin-5-ol (2.5 mg/egg/tumor) completely inhibited the formation of metastases in HEp #3 and increased the total content of lipid-bound sialic acid in the tumor by 63% (hematoside, monosialoganglioside, and disialoganglioside by 71, 99, and 67%, respectively). No change was seen in the content of lipid-bound sialic acid in HS #1. Treatment of HEp #3 with a smaller dose of the quinazolinol derivative (1.25 mg/egg) caused an average of 88% inhibition of metastasis, with a 37% increase in lipid-bound sialic acid. Another compound, 2,5-diphenylthiazolo-[5,4-d]thiazole (500 μg/egg), completely inhibited the formation of metastasis and caused a substantial increase in the amount of lipid-bound sialic acid (77%). The data showed the existence of a correlation between the level of gangliosides in HEp #3 and the ability of these tumors to metastasize.
A Multistate Outbreak of Infections Caused by Yersinia enterocolitica Transmitted by Pasteurized Milk
Authors: Carol O. Tacket
Journal: JAMA (1984)

In June and July 1982, a large interstate outbreak of<i>Yersinia enterocolitica</i>infections caused by an unusual serotype occurred in Tennessee, Arkansas, and Mississippi. Eighty-six percent of cases had enteritis characterized by fever, abdominal pain, and diarrhea. In three separate case-control studies, drinking milk pasteurized by plant A was statistically associated with illness. In a survey of randomly chosen households, 8.3% of persons who recalled having drunk milk from plant A during the suspect period experienced a yersiniosislike illness. Inspection of the plant and cultures of the available raw and pasteurized milk did not reveal the source or mechanism of contamination or a breach in normal pasteurizing technique. Although outbreaks of enteric disease caused by pasteurized milk are rare in the United States, the ability of<i>Y enterocolitica</i>to grow in milk at refrigeration temperatures makes pasteurized milk a possible vehicle for virulent<i>Y enterocolitica</i>. The extent to which milk is responsible for sporadic cases of yersiniosis is unknown. (<i>JAMA</i>1984;251:483-486)
ECG Abnormalities Associated With the Barium Enema
Authors: Gregory L. Eastwood
Journal: JAMA (1972)

Electrocardiographic monitoring of 95 patients who underwent barium enema examination (BE) revealed that ECG changes are common (46%) during the procedure and tend to occur more frequently in the elderly and in persons with heart disease. Over a third of the changes were judged "potentially serious." None of the subjects died or developed definite myocardial damage directly attributable to the BE. In one patient ischemic changes appeared on the 12-lead ECG 48 hours after the BE but were of uncertain significance and relation to the procedure. No elevations in serum enzyme (creatine phosphokinase and a hydroxybutyric dehydrogenase levels could be attributed to the BE. The use of a balloon-tipped enema catheter was associated with a greater, but not statistically significant, frequency of BE ECG abnormalities.
Recovery From Acute Intestinal Ischemia Without Bowel Resection
Authors: John K. Vyden
Journal: JAMA (1973)

Although intestinal infarction is often the result of a sudden massive occlusion of the superior mesenteric artery or vein, it also sometimes is caused by nonocclusive vascular insufficiency of the intestine secondary to a low cardiac output state. Such patients should be managed by vigorously treating the cause of the low cardiac output rather than undertaking resection of the bowel, which is seldom successful because the circulation is insufficient to permit primary healing.
Imported African Sleeping Sickness
Authors: David R. Perera
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Sleeping sickness imported from Africa has been reported infrequently in this country.<sup>1-3</sup>Nevertheless, Rhodesian and Gambian trypanosomiasis still exists in many parts of sub-Saharan Africa, and visitors to endemic areas may be exposed to infected tsetse flies. This report describes a patient with imported African trypanosomiasis diagnosed and treated in Florida. To our knowledge, this is the only instance recently in which the diagnosis was made after the patient's return to the United States. <h3>Report of a Case:—</h3> A 57-year-old white dentist returned to Florida in October 1968 from safari in Rhodesia and Botswana with an acute illness characterized by fever, chills, lethargy, malaise, axillary lymphadenopathy, and a skin lesion on the right forearm. The patient had spent two weeks hunting and camping in the bush, where he was bitten by numerous tsetse flies (<i>Glossina sp</i>). He received amodiaquine for malaria chemoprophylaxis, but as is common
Preischaemic as well as postischaemic application of a Na+/H+ exchange inhibitor reduces infarct size in pigs
Authors: S. Rohmann, H. Weygandt, K.-O. Minck
Journal: Cardiovascular Research (1995)

Journal Article Preischaemic as well as postischaemic application of a Na+/H+ exchange inhibitor reduces infarct size in pigs Get access Sven Rohmann, Sven Rohmann Department of Preclinical Cardiovascular Research, E. Merck, Frankfurterstr. 250, D-64271 Darmstadt, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Heinrich Weygandt, Heinrich Weygandt Department of Preclinical Cardiovascular Research, E. Merck, Frankfurterstr. 250, D-64271 Darmstadt, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Klaus-Otto Minck Klaus-Otto Minck Department of Preclinical Cardiovascular Research, E. Merck, Frankfurterstr. 250, D-64271 Darmstadt, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 30, Issue 6, December 1995, Pages 945–951, https://doi.org/10.1016/S0008-6363(95)00154-9 Published: 01 December 1995 Article history Received: 31 March 1995 Accepted: 04 August 1995 Published: 01 December 1995
Hormone replacement therapy
Authors: K. Shetty
Journal: BMJ (2002)

Contract needs to enable doctors to offer first class careEditor-Jenkins et al found that patients vary both in what they want from a consultation with their general practitioner and in what they get. 1 They found a poor correlation between these and the length of the consultation.The catchy front cover headline "Consultations don't have to be longer to be better" seriously overgeneralises these results.Some short consultations may be highly effective, but a systematic review earlier this year summarised a range of patient outcomes that are improved when doctors have more time. 2 In one large English survey 12% of patients complained about having insufficient time with their general practitioner, but this figure rose to 30% when patients were seen for five minutes or less. 3 It may be that the doctors need additional time in consultations-perhaps more than their patients.Medical practice has become more complex, and more needs to be done during the course of consultations.This may explain why clinical care is inferior in practices with short consultations. 4 Patients may sometimes get what they want in short consultations-but they may not always realise that it isn't good medical care.It is 16 years since David Morrell and I and colleagues published the first experimental study showing the limitations of short consultations. 5 It is well past time to consign surgeries booked at intervals as short as five minutes to history.The current payment system for general practitioners encourages a "pack 'em in and sell 'em cheap" approach to general practice.This needs to be addressed in the contract currently being negotiated so that all general practitioners have time to offer their patients first class care.
Fellowships, Grants, Awards
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Fellowships, Grants, Awards Get access JNCI: Journal of the National Cancer Institute, Volume 85, Issue 12, 16 June 1993, Pages 1011–1012, https://doi.org/10.1093/jnci/85.12.1011 Published: 16 June 1993
Replication of Herpes Simplex Virus in Cultures of Phytohemagglutinin-Stimulated Human Lymphocytes&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Bertha A. Bouroncle, M.D., Kathryn P. Clausen, M.D., Elizabeth M. Darner, M.S.
Journal: JNCI Journal of the National Cancer Institute (1970)

Primary cultures of normal human peripheral blood lymphocytes transformed in vitro by pyhtohemagglutinin (PHA) can support replication of human viruses. To establish a model for the identification of unknown viruses in this cell system, we studied the replication of herpes simplex virus (HSV) in PHA-stimulated lymphocytes both by infectivity titer and electron microscopic examination. Our studies documented the replication of HSV, of low infectivity, in cultures of PHA-stimulated normal lymphocytes. Maximum infectivity liters were reached in 48 hours. Unstimulated lymphocytes showed only a slight increase in viral infectivity liters. New virus was first observed by electron microscopy in the infected cultures 24 hours after inoculation. At 48 hours nearly all viable cells examined contained virus in various stages of proliferation. No evidence of replication was found in the nontransformed lymphocytes. Some morphologic alterations observed in the blastoid cells infected with HSV were not characteristic of PHA transformation alone. These included: complex nuclear membrane reduplication (blebs), increased cytoplasmic rough endoplasmic reticulum, and intracytoplasmic membranes resembling viral envelopes. Cultures of PHA-stimulated normal human lymphoctyes may be useful for identification of unknown human viruses and may prove especially valuable for the isolation of possible human lymphotrophic viruses.
Current Medical Literature
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Access Provided by Humber College JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account
Reform Not Abolition
Authors: Wallace D. Riley
Journal: JAMA (1984)

AT ITS meeting in December 1983, the American Medical Association's House of Delegates endorsed a policy recommending the abolition of the special defense of insanity and providing instead that new procedures should allow acquittal only when a defendant, as a result of mental disease or defect, lacked the state of mind required as an element of the offense charged. This policy, derived principally from the writings of Professor Norval Morris, is commonly referred to as the<i>mens rea</i>limitation. It is not a new idea and, while it has been adopted by the states of Montana, Idaho, and Utah, it has been rejected by Congress,<sup>1</sup>by the American Bar Association (ABA),<sup>2</sup>by the American Psychiatric Association,<sup>3</sup>and by the National Mental Health Association.<sup>4</sup>Still, there is a certain intellectual attractiveness as well as a logical clarity to the idea, and therefore its rejection deserves and requires explanation.
Case-Control Study of HIV Seroconversion in Health-Care Workers After Percutaneous Exposure to HIV-Infected Blood—France, United Kingdom, and United States, January 1988-August 1994
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Extraurinary Manifestations of Chronic Pyonephrosis
Authors: J B M Roberts, J C Gingell, D Kirk, R C L Feneley, P J B Smith
Journal: Journal of the Royal Society of Medicine (1983)

Twenty-five patients who underwent nephrectomy for chronic pyonephrosis were studied retrospectively. Such patients may present with a wide range of symptoms. Marked haematological and biochemical abnormalities are found, the most striking being a gross elevation of plasma viscosity (or ESR) and a raised alkaline phosphatase. The resulting picture often suggests extrarenal disease, and diagnostic confusion occurred in a number of patients.
The Rubin Test
Authors: Edward C. Hill
Journal: JAMA (1983)

The introduction of a foreign object or material through the cervical canal into the uterine cavity was considered a dangerous thing to do at the time that Isidor Rubin<sup>1</sup>first thought that it might be a way of demonstrating tubal patency. Even such a simple procedure as sounding the uterus was judged by many eminent gynecologists of that day to be a violation of acceptable medical practice. The endometrial cavity was considered sacrosanct. Nevertheless, Rubin was concerned because, other than by laparotomy, there was no reasonably good method to determine whether the tubes were open or closed. The conscientious physician was extremely reluctant to recommend abdominal surgery for this sole purpose because of the grave risks involved. Female infertility in those days was considered to be primarily a problem of cervical obstruction. The Pozzi operation, a type of tracheloplasty, was in vogue if there was, on pelvic examination, no