<i>Vital Signs</i>: Progress Toward Eliminating HIV as a Global Public Health Threat Through Scale-Up of Antiretroviral Therapy and Health System Strengthening Supported by the U.S. President’s Emergency Plan for AIDS Relief — Worldwide, 2004–2022
Authors: Helen M. Chun, Emilio Dirlikov, Mackenzie Hurlston Cox, Michelle Williams Sherlock, Yaa Obeng-Aduasare, Kimi Sato, Andrew C. Voetsch, Abraham D. Ater, Erin Rottinghaus Romano, Hank Tomlinson, Surbhi Modi, Angeli Achrekar, John Nkengasong, Simon Agolory, Josef Amann, Brittney Baack, Stephanie Behel, Anand Date, Jeff Hanson, William P. Killam, Hetal Patel, Sadhna Patel, Rituparna Pati, Laura Porter, Alicia Warner, Tadesse Wuhib, Clement Zeh, Ana Carolina Faria E Silva Santelli, Giselle Guevara, Rosa Elena Morales, Alexandre Kunumboa Ekra, Francois Kitenge, Luis Bonilla, Sikhathele Mazibuko, Tekeste Damena, Patrice Joseph, Sunita Upadhyaya, Indira Aitmagambetova, Jane Mwangi, Nazira Usmanova, Douangchanh Xaymounvong, Mugyenyi Asiimwe, Maida Alice, Gillian Jessina Masamha, Gram Mutandi, Solomon Odafe, Lacson Romel, Canisious Musoni, Mary Mogashoa, Alex Bolo, Aziz Nabidzhonov, George Mgomella, Rangsima Lolekha, Stella Alamo-Talisuna, Nataliya Podolchak, Chi K Nguyen, Silas Quaye, Annie Mwila, Ponesai Nyika
Journal: MMWR Morbidity and Mortality Weekly Report (2023)

In 2004, the U.S. President's Emergency Plan for AIDS Relief (PEPFAR), with CDC as a major U.S. government implementing agency, began providing HIV antiretroviral therapy (ART) worldwide. Through suppression of HIV viral load, effective ART reduces morbidity and mortality among persons with HIV infection and prevents vertical and sexual transmission.To describe program impact, data were analyzed from all PEPFAR programs and from six countries that have conducted nationally representative Population-based HIV Impact Assessment (PHIA) surveys, including PEPFAR programmatic data on the number of persons with HIV infection receiving PEPFAR-supported ART (2004-2022), rates of viral load coverage (the proportion of eligible persons with HIV infection who received a viral load test) and viral load suppression (proportion of persons who received a viral load test with <1,000 HIV copies per mL of blood) (2015-2022), and population viral load suppression rates in six countries that had two PHIA surveys conducted during 2015-2021. To assess health system strengthening, data on workforce and laboratory systems were analyzed.By September 2022, approximately 20 million persons with HIV infection in 54 countries were receiving PEPFAR-supported ART (62% CDC-supported); this number increased 300-fold from the 66,550 reported in September 2004. During 2015-2022, viral load coverage more than tripled, from 24% to 80%, and viral load suppression increased from 80% to 95%. Despite increases in viral load suppression rates and health system strengthening investments, variability exists in viral load coverage among some subpopulations (children aged <10 years, males, pregnant women, men who have sex with men [MSM], persons in prisons and other closed settings [persons in prisons], and transgender persons) and in viral load suppression among other subpopulations (pregnant and breastfeeding women, persons in prisons, and persons aged <20 years).Since 2004, PEPFAR has scaled up effective ART to approximately 20 million persons with HIV infection in 54 countries. To eliminate HIV as a global public health threat, achievements must be sustained and expanded to reach all subpopulations. CDC and PEPFAR remain committed to tackling HIV while strengthening public health systems and global health security.