tbuckley/cabot-search huggingface dataset:
Characterization of Oral Streptococci That Activate the Dietary Glycoside Rutin to a Mutagen
Authors: Edward J. Shillitoe, Charles I. Hoover, Susan J. Fisher, Maha Abdel-Salam, John S. Greenspan
Journal: JNCI Journal of the National Cancer Institute (1984)

Oral streptococci are described that hydrolyze the dietary glycoside rutin (CAS: 153-18-4), resulting in mutagenic activity. Bacteria that hydrolyze rutin were isolated from the mouth of each of 10 healthy volunteers. The activity was inducible, and the product was mutagenic in the Salmonella mutagenicity assay. These bacteria were present in the greatest proportion on the dorsum of the tongue where they formed 1.5% of the total cultivable microflora. The appearance of the colonies, cell morphology, and biochemical characteristics were those of Streptococcus milleri. However, rutin hydrolysis did not occur with any of 30 isolates of this species from blood of patients with bacteremia, with any of 4 stock strains, or with any of 14 strains of streptococci from the other 4 major oral species. Therefore, activation of rutin to a mutagen is not a universal function of the normal oral flora, but it can be accomplished by some strains of S. milleri.
The travelling athlete: issues relating to the Commonwealth Games, Malaysia, 1998
Authors: M Young, P Fricker, R Maughan, D MacAuley
Journal: British Journal of Sports Medicine (1998)

The international athlete is a global traveller.Such is the ease and speed of air travel that major international sporting events now take place throughout the world.This presents a variety of problems for the medical team and includes issues such as immunisation, vaccinations, jet lag, diet, and acclimatisation.The key to team care is preparation and, with the 1998 Commonwealth Games due to take place in Kuala Lumpur, Malaysia, in September, preparation must begin early.The main issues for the team of medical care providers relate to the three important phases in medical care: concerns before travel, minimising problems during travel, and providing care at the competition.
Murine Type C Retroviruses and Intracisternal A-Particles in Human Tumors Serially Passaged in Nude Mice&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Tralka, Tommie S., Yee, Carole L., Rabson, Arnold B., Wivel, Nelson A., Stromberg, Kurt J., Rabson, Alan S., Costa, José C.
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Murine Type C Retroviruses and Intracisternal A-Particles in Human Tumors Serially Passaged in Nude Mice Get access Tommie S. Tralka, Tommie S. Tralka 4 4Address reprint requests to Dr. Tralka, Building 10, Room 2N103, National Institutes of Health, Bethesda, Md. 20205. Search for other works by this author on: Oxford Academic PubMed Google Scholar Carole L. Yee, Carole L. Yee Search for other works by this author on: Oxford Academic PubMed Google Scholar Arnold B. Rabson, Arnold B. Rabson Search for other works by this author on: Oxford Academic PubMed Google Scholar Nelson A. Wivel, Nelson A. Wivel Search for other works by this author on: Oxford Academic PubMed Google Scholar Kurt J. Stromberg, Kurt J. Stromberg Search for other works by this author on: Oxford Academic PubMed Google Scholar Alan S. Rabson, Alan S. Rabson Search for other works by this author on: Oxford Academic PubMed Google Scholar José C. Costa José C. Costa Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 71, Issue 3, September 1983, Pages 591–599, https://doi.org/10.1093/jnci/71.3.591 Published: 01 September 1983 Article history Received: 29 December 1982 Accepted: 26 April 1983 Published: 01 September 1983
ESICM 2010 WEDNESDAY SESSIONS 13 October 2010
Authors: J Masclans, A Rodriguez, E Guerrero, J Bonastre, L Vidaur, J Almirall, L Cordero, B Gil Rueda, I Jimenez, M Martı, A Arenzana, J Pozo, S Ruı ´z-Santana, J Valle, J Sirvent, L Lorente, P Luque, L Figueira, J Nava, A Jaren, C Hermosa, A Marques, F Mariscal, R Zaragoza, A Loza, J Rello, Semicyuc Working Group, K Moorhead, L Piquilloud, T Desaive, J Roeseler, J Chase, L Vignaux, E Bialais, D Tassaux, P Jolliet, B Lambermont, R Fernandez, J Serrano, I Umaran, R Abizanda, A Carrillo, M Lopez-Pueyo, P Rascado, B Balerdi, B Suberviola, G Hernandez, D Scha ¨dler, G Elke, S Pulletz, N Haake, I Frerichs, J Scholz, G Zick, N Weiler
Journal: Intensive Care Medicine (2010)
Individual Gymnastics. A Handbook of Corrective and Remedial Gymnastics.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights from Recent Cancer Literature
Journal: Cancer Research (2015)

ALK Mutations as Predictive Biomarkers in NeuroblastomaBresler and colleagues characterize mutations in anaplastic lymphoma kinase (ALK), a cell surface receptor tyrosine kinase, in neuroblastoma.Among 1,596 patients, 8% showed at least one mutation.Mutations in three residues (R1275, F1174, and F1245) accounted for 85% of the identified mutations.Copy number gain was mutually exclusive with mutation.Multivariable analysis showed that ALK mutation was an independent predictor of poor survival.F1174 mutations were overrepresented in MYCN-amplified tumors, and patients with both mutations had very poor outcomes.Biochemical studies showed that mutant alleles activated tyrosine kinase domain autophosphorylation.A close correspondence was identified between transforming potential and in vitro-determined k cat values for autophosphorylation.Overall, these results suggest that ALK is a biomarker of disease status in neuroblastoma and provide clinical information to guide therapy.
Some Effects of Hypervitaminosis A on Metastasis of Spontaneous Breast Cancer in Mice
Authors: L. Weiss, E. D. Holyoke
Journal: JNCI Journal of the National Cancer Institute (1969)

The effects of hypervitaminosis A on the pulmonary metastatic pattern of spontaneous mammary tumors in mice were studied in three groups with spontaneous mammary tumors: an overall control group (I), a hypervitaminotic group (III) and a group (II), in which the mean body weight was kept at that of group III by diet restriction. A greater percentage of animals developed metastases in group III, and in these, more pulmonary metastases per animal occurred. In in vitro experiments, cells were liberated more easily from tumors of group III than in the other groups; cell detachment was made easier by lysosomal enzymes, and hypervitaminosis A neither demonstrably affected the retention of tumor cells in the lungs nor their growth in this organ. It is suggested that hypervitaminosis A promotes pulmonary metastasis through facilitated release of cells from primary tumors, which is mediated through released lysosomal enzymes. Other mechanisms of lysosomal activation, which may be immunological or due to chemotherapy, may also increase metastases.
Workload, Setting of Clinics Often Far From Ideal
Authors: Timothy F. Kirn
Journal: JAMA (1988)

THE PRAIRIE HOUSE is an old mansion on a street that years ago was lined with what then were Chicago's most expensive homes. When the heyday of the mansions was over, the warehouses and meat-packing plants moved in, only to become casualties in turn of the invention of the refrigerated railroad car. Today, the streets are strewn with broken glass and even the big commercial buildings stand empty. Prairie House, which is run by Substance Abuse Services, Inc, is typical of methadone clinics. It stands in a neighborhood so desolate that the rent is cheap and there is no one around to oppose the clinic's presence. Right now, it is handling patients from another clinic as well—one that lost its lease. Four hundred thirty patients are being treated. The facility is overcrowded, but fortunately no patients were lost when the other clinic was forced to move. Willie McCullough has been
Hyperbaric Oxygen in Hemolytic Crisis
Authors: Ole Myking
Journal: JAMA (1974)

A middle-aged woman developed an acute hemolytic anemia with warm antibodies. The cause remained unknown. Hemoglobin level fell rapidly to 3 gm/100 ml and symptoms of cerebral anoxia appeared. Compatible blood could not be found. Intermittent hyperbaric oxygen therapy had a striking effect on the cerebral symptoms and kept the patient alive during the critical period.
Seizures Reported With Tramadol
Authors: Laura H. Kahn
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Tramadol hydrochloride (Ultram, McNeil Pharmaceutical, Spring House, Pa) is a centrally acting, synthetic, opioid analgesic that was approved for marketing in the United States in March 1995 for the treatment of moderate to moderately severe pain. The recommended adult dosage is 50 mg to 100 mg every 4 to 6 hours, not to exceed 400 mg/d.<sup>1</sup> Within the first year after marketing approval in the United States, the Food and Drug Administration (FDA) received 83 reports of seizures among patients using tramadol. This led to labeling changes and issuance of a "Dear Doctor" letter.<sup>2</sup>During tramadol's second year on the market, the FDA received more than 200 reports of seizures. We describe the clinical features of seizure cases reported for tramadol. From the FDA's database of adverse drug events,<sup>3</sup>we retrieved all domestic US reports for tramadol coded for seizures that the FDA had
Morbidity and Mortality in Relation to Cigarette Smoking in Shanghai, China
Authors: Jian-Min Yuan
Journal: JAMA (1996)

<h3>Objective.</h3> —To evaluate prospectively the health risk of cigarette smoking in middle-aged men in Shanghai, China. <h3>Design.</h3> —Prospective cohort study with annual follow-up. <h3>Participants.</h3> —A total of 18244 male residents of Shanghai, China, enrolled in the study during January 1, 1986, through September 30, 1989, and actively followed via annual visits. <h3>Results.</h3> —By September 30, 1993, 852 deaths and 554 incident cancer cases were identified during the follow-up period, which averaged 5.4 years per subject. The overall incidence rate for cancer was 568 per 100 000 man-years, with the 3 leading sites being lung (146/100 000), stomach (116/100 000), and liver (81/100 000). Forty-one percent of all deaths were from cancer. Stroke was the most frequent cause of death unrelated to cancer, with an age-adjusted rate 4.2 times higher than that of US white men (201/100 000 vs 48/100 000), followed by ischemic heart disease, with an age-adjusted rate one-fifth that of US white men (69/100 000 vs 366/100 000). Compared with lifelong nonsmokers, the relative risks in heavy smokers (20 or more cigarettes per day) after adjustment for alcohol consumption were 2.2 for any incident cancer, 9.4 for incident lung cancer, 6.7 for head and neck cancer, and 1.8 for liver cancer. In terms of mortality, heavy smokers were at a 60% greater risk of death relative to lifelong nonsmokers; there was a 2.3-fold excess risk of death from cancer and 2-fold to 3-fold excess risk of death from heart disease. <h3>Conclusions.</h3> —Cigarette smoking is an important predictor of risk of cancer and mortality in men in Shanghai. Among the study subjects, 36% of all cases of cancer and 21% of all deaths could be attributed to cigarette smoking. (<i>JAMA</i>. 1996;275:1646-1650)
Correction: Article on Treatment of B-Cell Lymphoma
Journal: Clinical Cancer Research (2004)

In the article on B-Cell Lymphoma in the April 1, 2004 issue of Clinical Cancer Research, Figures 1 and 2 were reversed. The correct figures appear below:Sapra P and Allen TM. Improved outcome when B-cell lymphoma is treated with combinations of immunoliposomal anticancer drugs targeted to both the CD19 and CD20 epitopes. Clin Cancer Res 2004;10:2530–37.
Lethal Congenital Anomalies as a Cause of Birth-Weight—Specific Neonatal Mortality
Authors: Robert L. Goldenberg
Journal: JAMA (1983)

The percentage of neonatal mortality caused by lethal congenital anomalies and the distribution of specific anomalies in various birth-weight groups are presented. State vital statistics data and autopsy-confirmed data from a single hospital are compared. Of neonates who died, less than 5% who were born weighing between 500 and 999 g died of a congenital anomaly, and nearly 45% who were born weighing more than 2,500 g died of a congenital anomaly. Most deaths associated with congenital anomalies in infants born weighing more than 2,500 g are cardiac in origin. Twenty-three percent of all neonatal deaths in Alabama are attributed to a lethal congenital anomaly. Use of these data to define limits to future improvements in neonatal mortality by standard medical care is discussed. (<i>JAMA</i>1983;250:513-515)
The Economic Impact and Multiplier Effect of a Family Practice Clinic on an Academic Medical Center
Authors: Ronald Schneeweiss
Journal: JAMA (1989)

Academic medical centers are facing the need to expand their primary care referral base in an increasingly competitive medical environment. This study describes the medical care provided during a 1-year period to 6304 patients registered with a family practice clinic located in an academic medical center. The relative distribution of primary care, secondary referrals, inpatient admissions, and their associated costs are presented. The multiplier effect of the primary care clinic on the academic medical center was substantial. For every $1 billed for ambulatory primary care, there was $6.40 billed elsewhere in the system. Each full-time equivalent family physician generated a calculated sum of $784 752 in direct, billed charges for the hospital and $241 276 in professional fees for the other specialty consultants. The cost of supporting a primary care clinic is likely to be more than offset by the revenues generated from the use of hospital and referral services by patients who received care in the primary care setting. (<i>JAMA</i>. 1989;262:370-375)
Methotrexate and Psoriasis
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Principles of Mental Hygiene.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnostik und Therapie der Magenkrankheiten.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Growing world of gastrointestinal endoscopy
Authors: Michael Reed
Journal: JAMA (1982)

In this age of computed tomographic scans, ultrasound, and nuclear magnetic resonance, medical technology grows more exciting, if more complex and expensive, each day. Thus it is easy to overlook the growing sophistication and importance of a less exotic instrument like the endoscope. At the recent Digestive Disease Week (DDW) meetings in Chicago, a large number of plenary- and poster-session presentations and commercial exhibits coalesced into a fascinating documentation of the current significance and promise of this device. In his 20 years as director of the program of gastroenterology at the University of Wisconsin Medical School, Madison, John F. Morrissey, MD, says he has observed endoscopy's growth from a struggling young technique practiced with comparatively primitive endoscopes to a precise and highly valued procedure based on technologically superb equipment. Today, endoscopes and endoscopists are in the midst of an extension from observation to manipulation and from diagnosis to therapy. In
Medical schools in the United States
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Positron Computed Tomography
Authors: Michael E. Phelps
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Breast Cancer and Cigarette Smoking
Authors: Lynn Rosenberg, Pamela J. Schwingl, David W. Kaufman, Donald R. Miller, Susan P. Helmrich, Paul D. Stolley, David Schottenfeld, Samuel Shapiro
Journal: New England Journal of Medicine (1984)

It has been suggested that cigarette smoking may reduce the incidence of breast cancer, perhaps by as much as 20 per cent. To evaluate the relation between breast-cancer risk and smoking, we studied 2160 women with breast cancer and 717 controls who had been admitted to the hospital for cancer of the ovary, cancer of the colon or rectum, malignant melanoma, or lymphoreticular cancers. As compared with women who had never smoked, the estimated relative risk of breast cancer was 1.1 for current smokers of any amount (95 per cent confidence interval, 0.9 to 1.3), and 1.0 (0.8 to 1.3) for heavy smokers (15 or more cigarettes per day). Allowance for all identified potential confounding factors did not materially alter the results. There was no indication that age at commencement of smoking was related to the risk, nor was there evidence of an effect of smoking within the categories of age at first pregnancy or age at menopause. The data provide evidence against the hypothesis that smoking may reduce the incidence of breast cancer by 20 per cent. (N Engl J Med 1984; 310:92–4.)