Highlighted research articles
Journal: Cancer Discovery (2023)

In This Issue| April 03 2023 Highlighted research articles Author & Article Information Online ISSN: 2159-8290 Print ISSN: 2159-8274 ©2023 American Association for Cancer Research2023American Association for Cancer Research Cancer Discov (2023) 13 (4): 799–800. https://doi.org/10.1158/2159-8290.CD-13-4-ITI Related Content This is a related article to: Dynamics of Age- versus Therapy-Related Clonal Hematopoiesis in Long-term Survivors of Pediatric Cancer This is a related article to: Intratumoral Heterogeneity and Clonal Evolution Induced by HPV Integration This is a related article to: Antibody–Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer View more This is a related article to: Blocking Genomic Instability Prevents Acquired Resistance to MAPK Inhibitor Therapy in Melanoma This is a related article to: Genomic Instability and Protumoral Inflammation Are Associated with Primary Resistance to Anti–PD-1 + Antiangiogenesis in Malignant Pleural Mesothelioma This is a related article to: LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma This is a related article to: Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and Is Associated with Worse Outcomes This is a related article to: Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma View less See also related Dynamics of Age- versus Therapy-Related Clonal Hematopoiesis in Long-term Survivors of Pediatric CancerClonal Hematopoiesis in Pediatric Cancer Survivors Intratumoral Heterogeneity and Clonal Evolution Induced by HPV IntegrationHPV Integration Drives Heterocateny Antibody–Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung CancerOvercoming Resistance by T Moiety–Exatecan ADCs Blocking Genomic Instability Prevents Acquired Resistance to MAPK Inhibitor Therapy in MelanomaDNA-PKCS NHEJ Underlie ecDNAs/CGRs Driving MAPKi Resistance Genomic Instability and Protumoral Inflammation Are Associated with Primary Resistance to Anti–PD-1 + Antiangiogenesis in Malignant Pleural Mesothelioma Resistance to Anti–PD-1 and Antiangiogenics in Mesothelioma LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung AdenocarcinomaLKB1–SIK–TPI1 Is a Liability in Human but Not Mouse KP LUAD Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and Is Associated with Worse OutcomesecDNA Contributes to Small Cell Lung Cancer Heterogeneity Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for GlioblastomaTargeting Microglial Lipid Metabolism Enhances ICB For GBM Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record April 3 2023 Citation Highlighted research articles. Cancer Discov 1 April 2023; 13 (4): 799–800. https://doi.org/10.1158/2159-8290.CD-13-4-ITI Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Pediatric cancer survivors are at risk of accelerated physiologic aging. Hagiwara and colleagues profiled 2,860 long-term survivors by deep sequencing and detected clonal hematopoiesis (CH) in 15% of survivors, which is significantly higher than in community controls (8.5%). CH in survivors is associated with exposures to alkylating agents, radiation, and bleomycin and is significantly enriched in TP53 and STAT3. Mutations in STAT3, characterized as a CH gene specific to Hodgkin lymphoma survivors, occur predominantly in T cells and are contributed by SBS25, a mutational signature associated with procarbazine exposure. Longitudinal monitoring is recommended to ascertain the long-term effects of CH in pediatric cancer survivors. See article, p. 844. Antiangiogenics potentiate immune checkpoint blockade efficacy in advanced mesotheliomas, but a majority of patients present primary resistance to this combination. Danlos and colleagues analyzed sequential fixed, frozen, and fresh blood and tumor samples from patients with mesothelioma treated with pembrolizumab... You do not currently have access to this content.