tbuckley/cabot-search huggingface dataset:
Transgender and non-binary people’s perception of their healthcare in relation to endometriosis
Authors: Cheryl Eder, Rizwana Roomaney
Journal: International Journal of Transgender Health (2023)

Endometriosis is described as a gynecological disease that can severely impact on people's quality of life. Much of endometriosis research and literature is focused on cis women, although gender diverse people and cis men have been diagnosed with this disease. Cis women have reported problems in their healthcare for endometriosis due to delays in diagnosis and a lack of support in their treatment. Gender diverse people have reported to experience discrimination in healthcare settings. There is a lack of research on gender diverse people's experience of living with endometriosis and little is known about their experience of healthcare for endometriosis.
Counteracting tryptophan metabolism alterations as a new therapeutic strategy for rheumatoid arthritis
Authors: David Moulin, Marie Millard, Mahdia Taïeb, Chloé Michaudel, Anne Aucouturier, Antoine Lefèvre, Luis G Bermúdez-Humarán, Philippe Langella, Youssouf Sereme, Kristell Wanherdrick, Preeti Gautam, Xavier Mariette, Philippe Dieudé, Jacques-Eric Gottenberg, Jean-Yves Jouzeau, David Skurnik, Patrick Emond, Denis Mulleman, Jérémie Sellam, Harry Sokol
Journal: Annals of the Rheumatic Diseases (2023)

Objectives Alterations in tryptophan (Trp) metabolism have been reported in inflammatory diseases, including rheumatoid arthritis (RA). However, understanding whether these alterations participate in RA development and can be considered putative therapeutic targets remains undetermined. In this study, we combined quantitative Trp metabolomics in the serum from patients with RA and corrective administration of a recombinant enzyme in experimental arthritis to address this question. Methods Targeted quantitative Trp metabolomics was performed on the serum from 574 previously untreated patients with RA from the ESPOIR (Etude et Suivi des POlyarthrites Indifférenciées Récentes) cohort and 98 healthy subjects. A validation cohort involved 69 established patients with RA. Dosages were also done on the serum of collagen-induced arthritis (CIA) and collagen antibody-induced arthritis (CAIA) mice and controls. A proof-of-concept study evaluating the therapeutic potency of targeting the kynurenine pathway was performed in the CAIA model. Results Differential analysis revealed dramatic changes in Trp metabolite levels in patients with RA compared with healthy controls. Decreased levels of kynurenic (KYNA) and xanthurenic (XANA) acids and indole derivatives, as well as an increased level of quinolinic acid (QUIN), were found in the serum of patients with RA. They correlated positively with disease severity (assessed by both circulating biomarkers and disease activity scores) and negatively with quality-of-life scores. Similar profiles of kynurenine pathway metabolites were observed in the CAIA and CIA models. From a mechanistic perspective, we demonstrated that QUIN favours human fibroblast-like synoviocyte proliferation and affected their cellular metabolism, through inducing both mitochondrial respiration and glycolysis. Finally, systemic administration of the recombinant enzyme aminoadipate aminotransferase, responsible for the generation of XANA and KYNA, was protective in the CAIA model. Conclusions Altogether, our preclinical and clinical data indicate that alterations in the Trp metabolism play an active role in the pathogenesis of RA and could be considered as a new therapeutic avenue.
Senescent cells in giant cell arteritis display an inflammatory phenotype participating in tissue injury via IL-6-dependent pathways
Authors: Dimitris Veroutis, Ourania D Argyropoulou, Andreas V Goules, Konstantinos Kambas, Dimitris Anastasios Palamidas, Konstantinos Evangelou, Sophia Havaki, Aikaterini Polyzou, Dimitrios Valakos, Evangelia Xingi, Elli Karatza, Kyriaki A Boki, Alberto Cavazza, Christos Kittas, Dimitris Thanos, Caterina Ricordi, Chiara Marvisi, Francesco Muratore, Elena Galli, Stefania Croci, Carlo Salvarani, Vassilis G Gorgoulis, Athanasios G Tzioufas
Journal: Annals of the Rheumatic Diseases (2023)

Objectives Age is the strongest risk factor of giant cell arteritis (GCA), implying a possible pathogenetic role of cellular senescence. To address this question, we applied an established senescence specific multimarker algorithm in temporal artery biopsies (TABs) of GCA patients. Methods 75(+) TABs from GCA patients, 22(−) TABs from polymyalgia rheumatica (PMR) patients and 10(−) TABs from non-GCA/non-PMR patients were retrospectively retrieved and analysed. Synovial tissue specimens from patients with inflammatory arthritis and aorta tissue were used as disease control samples. Senescent cells and their histological origin were identified with specific cellular markers; IL-6 and MMP-9 were investigated as components of the senescent associated secretory phenotype by triple costaining. GCA or PMR artery culture supernatants were applied to fibroblasts, HUVECs and monocytes with or without IL-6R blocking agent to explore the induction of IL-6-associated cellular senescence. Results Senescent cells were present in GCA arteries at higher proportion compared with PMR (9.50% vs 2.66%, respectively, p&lt;0.0001) and were mainly originated from fibroblasts, macrophages and endothelial cells. IL-6 was expressed by senescent fibroblasts, and macrophages while MMP-9 by senescent fibroblasts only. IL-6(+) senescent cells were associated with the extension of vascular inflammation (transmural inflammation vs adventitia limited disease: 10.02% vs 4.37%, respectively, p&lt;0.0001). GCA but not PMR artery culture supernatant could induce IL-6-associated senescence that was partially inhibited by IL-6R blockade. Conclusions Senescent cells with inflammatory phenotype are present in GCA arteries and are associated with the tissue inflammatory bulk, suggesting a potential implication in disease pathogenesis.
AI-enabled ChatGPT or LLM: a new algorithm is required for plagiarism-free scientific writing
Authors: Soumen Pal, Manojit Bhattacharya, Md. Aminul Islam, Chiranjib Chakraborty
Journal: International Journal of Surgery (2023)

Pal, Soumen PhD; Bhattacharya, Manojit PhD; Islam, Md. Aminul; Chakraborty, Chiranjib PhD Author Information
Updated disease distributions, risk factors, and trends of laryngeal cancer: a global analysis of cancer registries
Authors: Junjie Huang, Sze Chai Chan, Samantha Ko, Veeleah Lok, Lin Zhang, Xu Lin, Don Eliseo Lucero-Prisno, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin CS Wong
Journal: International Journal of Surgery (2023)

Though the laryngeal cancer only has 1% of the total cancer cases and related deaths, it is a type of head and neck cancers with the highest prevalence. This study aims to investigate the epidemiological trend of laryngeal cancer with updated data on the global distribution of the disease burden.
Comparison of perioperative outcomes of selective arterial clipping guided by near-infrared fluorescence imaging using indocyanine green versus undergoing standard robotic-assisted partial nephrectomy: a systematic review and meta-analysis
Authors: Lin Zhou, Junjie Zhou, Hui Shuai, Qian Xu, Ying Tan, Jia Luo, Pengjun Xu, Xi Duan, Xiaorong Mao, Shanshan Wang, Tao Wu
Journal: International Journal of Surgery (2023)

Background: This study employs a meta-analytic approach to investigate the impact of robotic-assisted partial nephrectomy, with and without near-infrared fluorescence imaging (NIRF-RAPN vs S-RAPN), on patients’ perioperative outcomes and postoperative changes in renal function. Materials and methods: The authors conducted a comprehensive and rigorous systematic review and cumulative meta-analysis of primary outcomes following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), AMSTAR (Assessing the Methodological Quality of Systematic Reviews) Guidelines, and Risk-of-Bias Tool (RoB2). To ensure a thorough search, the authors systematically searched five major databases, including Medline, PubMed, Cochrane Library, Scopus, and Web of Science, from databases’ inception to April 2023. Results: No significant differences were found between the two groups in terms of age ( P =0.19), right side ( P =0.54), BMI ( P =0.39), complexity score ( P =0.89), tumor size ( P =0.88), operating time ( P =0.39), estimated blood loss ( P =0.47), length of stay ( P =0.87), complications ( P =0.20), transfusion ( P =0.36), and positive margins ( P =0.38). However, it is noteworthy that the NIRF-RAPN group exhibited significant reductions in warm ischemia time ( P =0.001), the percentage change in estimated glomerular filtration rate at discharge ( P =0.01) compared to the S-RAPN group. Conclusion: This meta-analysis provides evidence that the group undergoing NIRF-RAPN showed a statistically significant protective effect on the estimated glomerular filtration rate (eGFR).
Long-term quality of life between duodenum-preserving pancreatic head resection and pancreatoduodenectomy: a systematic review and meta-analysis
Authors: Taoyuan Yin, Jingjing Wen, Tingting Zhen, Yangwei Liao, Zhenxiong Zhang, Hongtao Zhu, Min Wang, Shutao Pan, Xingjun Guo, Hang Zhang, Renyi Qin
Journal: International Journal of Surgery (2023)

The authors aimed to compare the differences in quality of life (QOL) and overall survival (OS) between duodenum-preserving pancreatic head resection (DPPHR) and pancreatoduodenectomy (PD) during long-term follow-up. DPPHR and PD have been shown to be effective in alleviating symptoms and controlling malignancies, but there is ongoing debate over whether DPPHR has an advantage over PD in terms of long-term benefits.
Breast density reduction as a predictor for prognosis in premenopausal women with estrogen receptor-positive breast cancer: an exploratory analysis of the updated ASTRRA study
Authors: Soong June Bae, Hee Jeong Kim, Hyun-Ah Kim, Jai Min Ryu, Seho Park, Eun-Gyeong Lee, Seock-Ah Im, Yongsik Jung, Min Ho Park, Kyong Hwa Park, Su Hwan Kang, Eunhwa Park, Sung Yong Kim, Min Hyuk Lee, Lee Su Kim, Anbok Lee, Woo Chul Noh, Sungchan Gwark, Seonok Kim, Joon Jeong
Journal: International Journal of Surgery (2023)

Background: While the relationship between mammographic breast density reduction (MDR) and endocrine therapy efficacy has been reported in estrogen receptor-positive breast cancer, it is still unclear in premenopausal women, especially in the case of adding ovarian function suppression (OFS) to anti-hormone therapy. We investigated the impact of MDR on prognosis stratified by treatment based on the updated results of the ASTRRA trial. Materials and Methods: The ASTRRA trial, a randomized phase III study, showed that adding OFS to tamoxifen (TAM) improved survival in premenopausal women with estrogen receptor (ER)-positive breast cancer after chemotherapy. We updated survival outcomes and assessed mammography before treatment and the annual follow-up mammography for up to 5 years after treatment initiation. Mammographic density (MD) was classified into four categories based on the Breast Imaging Reporting and Data System. MDR-positivity was defined as a downgrade in MD grade on follow-up mammography up to 2 years after randomization, with pretreatment MD grade as a reference. Results: We evaluated MDR in 944 of the 1282 patients from the trial, and 813 (86.2%) had grade III or IV MD. There was no difference in the MDR-positivity rate between the two treatment groups (TAM-only group (106/476 [22.3%]) vs. TAM+OFS group (89/468 [19.0%]); P =0.217). MDR-positivity was significantly associated with better disease-free survival (DFS) in the TAM+OFS group (estimated 8-year DFS: 93.1% in MDR-positive vs. 82.0% in MDR-negative patients; HR:0.37; 95% CI:0.16-0.85; P =0.019), but not in the TAM-only group ( P interaction =0.039). MDR-positive patients who received TAM+OFS had a favorable DFS compared to MDR-negative patients who received only TAM (HR:0.30; 95% CI:0.13-0.70; P =0.005). Conclusion: Although the proportion of MDR-positive patients was comparable between both treatment groups, MDR-positivity was independently associated with favorable outcomes only in the TAM+OFS group.
A commentary on the article entitled ‘The value of total caudate lobe resection for hilar cholangiocarcinoma’
Authors: Hongsheng Wu, Biling Liao, Keqiang Ma
Journal: International Journal of Surgery (2023)

Department of Hepatobiliary Surgery, Affiliated Huadu Hospital, Southern Medical University/People's Hospital of Huadu District, Huadu District, Guang Zhou City, China Keqiang Ma Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: (Department of Hepatobiliary Surgery, Affiliated Huadu Hospital, Southern Medical University/People's Hospital of Huadu District, 48 Xinhua Road, Xinhua Street, Huadu District, Guangzhou City, China, 510800, PR China. E-mail address: [email protected] (K. Ma). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Six steps for a successful aesthetic free flap reconstruction after minimally invasive mastectomy: a retrospective case-control study
Authors: Allen Wei-Jiat Wong, Wen-Ling Kuo, David Chon-Fok Cheong, Hsiu-Pei Tsai, Shu-Wei Kao, Chia-Fang Chen, Jung-Ju Huang
Journal: International Journal of Surgery (2023)

Objective: Breast cancer treatment has evolved to the modern skin-sparing mastectomy and nipple-sparing mastectomy. To better perform these surgeries, minimally invasive techniques using the endoscope, or Da Vinci Robotic Surgery platform have been developed. The deep inferior epigastric perforator (DIEP) flap is the gold standard in breast reconstruction, but it is still not commonly performed after minimally invasive mastectomy due technical difficulty. Here the authors introduced six key steps to a successful aesthetic autologous free flap reconstruction in in minimally invasive mastectomies. Methods: There are six main steps to our technique: placement of mastectomy incision, precise flap design after angiography studies, trial of shaping, transcutaneous medial suture, footprint recreation and postoperative shaping with bra. Between November 2018 and July 2022, a total of 67 immediate breast reconstructions using free perforator flaps were performed in 63 patients after minimally invasive nipple-sparing mastectomy. Results: The results from the minimally invasive mastectomy group were compared with a group of conventional mastectomy patients ( n = 41) performed during the same period. There were no significant differences in flap exploration rates. One hundred percent of the flaps survived. In the minimally invasive group, the final scar was placed in the lateral region, where it would be hidden from the anterior view. Only 70.7% of the conventional mastectomy group could achieve a hidden lateral scar ( P &lt;0.001). The aesthetic revision rates were similar between two groups. Conclusion: With attention to the six steps above, autologous free flap reconstruction can be offered reliably in the setting of minimally invasive mastectomy.
Reproducibility and predictive value of three grading systems for intraoperative adverse events in a cohort of abdominal surgery
Authors: L. Gawria, P. Krielen, M.W.J. Stommel, H. van Goor, R.P.G. ten Broek
Journal: International Journal of Surgery (2023)

Introduction: Intraoperative adverse events (iAEs) are increasingly recognized for their impact on patient outcomes. The Kaafarani classification and Surgical Apgar Score (SAS) were developed to assess the intraoperative course; however, both have their drawbacks. ClassIntra was validated for iAEs of any origin. This study compares the Kaafarani and SAS to ClassIntra considering predictive value and interrater reliability in a cohort of abdominal surgery to support implementation of a classification in clinical practice. Methods: The authors made use of the LAParotomy or LAParoscopy and ADhesiolysis (LAPAD) study database of elective abdominal surgery. Detailed descriptions on iAEs were collected in real-time by a researcher. For the current research aim, all iAEs were graded according ClassIntra, Kaafarani, and SAS (score ≤4). The predictive value was assessed using univariable and multivariable linear regression and the area under the receiver operating curve (AUROC). Two teams graded ClassIntra and Kaafarani to assess the interrater reliability using Cohen’s Kappa. Results: A total of 755 surgeries were included, in which 335 (44%) iAEs were graded according to ClassIntra, 228 (30%) to Kaafarani, and 130 (20%) to SAS. All classifications were significantly correlated to postoperative complications, with an AUROC of 0.67 (95% CI: 0.62–0.72), 0.64 (0.59–0.70), and 0.71 (0.56–0.76), respectively. For the secondary endpoint, the interrater reliability of ClassIntra with κ 0.87 (95% CI: 0.84–0.90) and Kaafarani 0.90 (95% CI: 0.87–0.93) was both strong. Conclusion: ClassIntra, Kaafarani, and SAS can be used for reporting of iAEs in abdominal surgery with good predictive value for postoperative complications, with strong reliability. ClassIntra, compared with Kaafarani and SAS, included the most iAEs and has the most comprehensive definition suitable for uniform reporting of iAEs in clinical practice and research.
Longitudinal changes in renal parenchymal volume and function status after partial nephrectomy: a retrospective cohort study
Authors: Longbin Xiong, Xiangpeng Zou, Xin Luo, Shaohan Yin, Yixin Huang, Kang Ning, Dongxiang Wen, Zhaohui Zhou, Jun Wang, Zhen Li, Jiawei Chen, Jibin Li, Wei Peng, Shengjie Guo, Pei Dong, Fangjian Zhou, Hui Han, Yulu Peng, Chunping Yu, Zhiling Zhang
Journal: International Journal of Surgery (2023)

Background: The ipsilateral renal parenchymal volume (RPV) experiences a sharp decrease shortly after partial nephrectomy (PN), mainly due to surgical remove or devascularization of kidney tissue. However, the subsequent change of RPV and its association with glomerular filtration rate (GFR) fast decline remains unknown. Our objective was to investigate the change of ipsilateral RPV and renal function status from new baseline (1–12 months after PN) to latest follow-up (≥1 year) after PN, and to explore factors associated with ipsilateral RPV decrease rate and correlation between RPV decrease and GFR fast decline. Materials and methods: A retrospective review of 367 patients with PN was conducted. Three-dimensional reconstruction of computed tomography (CT)/MRI images was performed for RPV calculation. Spectrum score was used to assess the degree of acute kidney injury (AKI) in the operated kidney after PN. GFR decline greater than 3 ml/min/1.73 m 2 /year was defined as GFR fast decline. One hundred fourteen patients underwent abdominal surgery was used as control. Predictive factors for subsequent decrease of RPV rate and GFR fast decline were evaluated by linear and logistic regression, respectively. Results: With a median interval time of 21.1 (interquartile range:13.8–35.5) months, median ipsilateral RPV significantly decreased from 118.7 (interquartile range:100.7–137.1) ml at new baseline to 111.8 (IQR: 92.3–131.3) ml at latest follow-up. The interval time [β: 1.36(0.71–2.01), P &lt;0.001] and spectrum score [β: 5.83 (2.92–8.74), P &lt;0.001] were identified as independent predictors of ipsilateral RPV decrease rate. GFR fast decline was observed in 101 (27.5%) patients. Annual ipsilateral RPV decrease rate [odds ratio:1.67 (1.05–2.67), P =0.03] and overweight [odds ratio:1.63 (1.02–2.60), P =0.04] were independent predictors of GFR fast decline. Conclusions: Ipsilateral RPV experienced a moderate but significant decrease during follow-up after PN, especially in those with severer acute kidney injury. The presence of GFR fast decline was found to be associated with reduction of ipsilateral RPV, particularly in overweight individuals.
Demystifying the global outbreak of severe acute hepatitis of unknown aetiology in children: A systematic review and meta-analysis
Authors: Julie Phan, Guy D. Eslick, Elizabeth J. Elliott
Journal: Journal of Infection (2023)

The sudden outbreak of severe acute hepatitis of unknown aetiology (SAHUA) in the first half of 2022 affected more than 1010 children in 35 countries worldwide. Dire clinical outcomes, such as acute liver failure necessitating transplantation, neurological symptoms, long-term sequelae, and death, highlight the need to determine the pathogenesis of this condition. Hypotheses on the aetiology include adenovirus and SARS-CoV-2 infections and an aberrant immune response to multiple pathogen exposure following lifting of lockdown measures but further investigation is required to reach an informed consensus.
Risk of infections among patients with psoriasis on Janus kinase inhibitor treatment: A systematic review and meta-analysis
Authors: Nawar Tarafdar, Muskaan Sachdeva, Natnaiel M. Dubale, Iryna Savinova, Yuliya Lytvyn, Khalad Maliyar, Jorge R. Georgakopoulos, Asfandyar Mufti, Jensen Yeung
Journal: Journal of the American Academy of Dermatology (2023)
Comparison of comorbidities and adverse events in dermatology and rheumatology patients prescribed tofacitinib: A retrospective analysis
Authors: Carli D. Needle, Elizabeth J. Klein, Jessica Gjonaj, Ambika Nohria, Maria Karim, Lynn Liu, Jinal Shah, Rebecca A. Betensky, Michael Garshick, Kristen Lo Sicco, Theodora K. Karagounis
Journal: Journal of the American Academy of Dermatology (2023)
PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2
Authors: Cong Jiang, Jing Liu, Shaohui He, Wei Xu, Runzhi Huang, Weijuan Pan, Xiaolong Li, Xiaoming Dai, Jianping Guo, Tao Zhang, Hiroyuki Inuzuka, Ping Wang, John M. Asara, Jianru Xiao, Wenyi Wei
Journal: Cell Metabolism (2023)
A novel dual serotonin transporter and M-channel inhibitor D01 for antidepression and cognitive improvement
Authors: Yaqin Wei, Xiangqing Xu, Qiang Guo, Song Zhao, Yinli Qiu, Dongli Wang, Wenwen Yu, Yani Liu, KeWei Wang
Journal: Acta Pharmaceutica Sinica B (2023)

Cognitive dysfunction is a core symptom common in psychiatric disorders including depression that is primarily managed by antidepressants lacking efficacy in improving cognition. In this study, we report a novel dual serotonin transporter and voltage-gated potassium Kv7/KCNQ/M-channel inhibitor D01 (a 2-methyl-3-aryloxy-3-heteroarylpropylamines derivative) that exhibits both anti-depression effects and improvements in cognition. D01 inhibits serotonin transporters (