tbuckley/cabot-search huggingface dataset:
HTLV-III Antibodies in Drug-Addicted Prostitutes Used by US Soldiers in Italy
Authors: Umberto Tirelli
Journal: JAMA (1986)

<h3>To the Editor.—</h3> The controversial issue of the human T-cell lymphotropic virus type III (HTLV-III) infection rate among US soldiers in Berlin and its relationship with use of prostitutes,<sup>1,2</sup>in particular intravenous drug abusers, prompted us to report our data from Italy. To study the relationship between HTLV-III infection and the development of malignant lymphoma, 315 intravenous drug abusers seen in five centers for drug addicts from three provinces (Pordenone, Udine, and Gorizia) of Friuli Venezia Giulia, a region of 1.5 million inhabitants close to the borders of Austria and Yugoslavia, were clinically examined. They were also given laboratory tests including an HTLV-III antibody test (enzyme-linked immunosorbent assay) and T4/T8 ratios and completed a questionnaire on their drug abuse and sexual behavior. Human T-cell lymphotropic virus type III antibodies were detected in 86 (27% ) of the overall population, and 65 intravenous drug abusers (21%) were affected by persistent generalized
Handbuch der Biochemie des Menschen und der Tiere
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical records for mental health services; a guide to the study and development of clinical records systems including a manual of model forms and procedures.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Need to Redefine Levels of Surgical Care
Authors: James E. Davis
Journal: JAMA (1984)

IN RECENT years, both the number and variety of surgical procedures performed on nonhospitalized patients have increased markedly. These procedures are now being accomplished safely and without increased risk to patients. This method of avoiding hospitalization for patients with surgical problems of even intermediate magnitude is cost-effective, readily accepted by patients, and has improved the efficiency of surgical care delivery throughout the nation. However, the classification and differentiation of these patients and the operations they receive are unclear, and much confusion results.<sup>1</sup>We have an urgent need to redefine the levels of surgical care that we so competently provide. Until recently, all surgical care was thought of as being provided either on an inpatient or outpatient basis, obviously determined by whether or not the patient was admitted to the hospital. In the last decade, major advances in surgical and anesthetic techniques, shorteracting anesthetic agents, the advent of milder yet adequate
Highlights of This Issue
Journal: Clinical Cancer Research (2010)

Oxygen levels can dictate the expression of many genes, potentially altering immunogenic properties important for tumor cell–based vaccines. In this issue, Olin and colleagues demonstrate that in murine models of glioma and breast carcinoma, 5% O2-derived vaccines could enhance in vivo tumoricidal activity, resulting in extended survival. In the glioma cavity of mice treated with lysate vaccines from 5% O2, the induction of caspase-3 in glioma cells by multiple CD3+ lymphocytes was observed. These findings have important implications for the development of cancer vaccines, which are typically taken from cells cultured in atmospheric oxygen (about 20% O2).A better understanding of the functional differences between HIF-1α and HIF-2α in oral squamous cell carcinoma (OSCC) is needed. Zhu and colleagues evaluated correlations between HIF-1/2α expression and clinical-pathological characteristics of OSCC patients, investigated HIF-1α/2α-dependent target genes in OSCC cell lines, and examined the contribution of HIF-1α/2α to xenograft tumor growth, angiogenesis, and apoptosis. HIF-1α and HIF-2α correlated with different clinical-pathological parameters, stabilized at different oxygen levels, and regulated different genes in OSCC. However, both HIF-1α and HIF-2α had promoting roles in tumor angiogenesis and growth, suggesting that combined targeting of HIF-1α and HIF-2α may improve outcome.Carnitine (an essential cofactor for mitochondrial fatty acid oxidation) is reabsorbed by the luminal transporter OCTN2. In humans, cisplatin causes urinary loss of carnitine. To determine the effect cisplatin has on OCTN2 function, Lancaster and colleagues measured carnitine and acetylcarnitine excretion in urine collected from mice with/without cisplatin administration. Cisplatin caused increased urinary excretion of carnitine and acetylcarnitine in wild-type mice but not in Oct1/2(-/-) mice. Gene expression analysis on untreated/treated kidneys showed multiple genes in wild-type mice were downregulated compared to Oct1/2(-/-) mice, including those involved in carnitine shuttling. These findings highlight the role of Oct1/2 in cisplatin-related disturbances in carnitine homeostasis.Lung squamous cell carcinoma (SCC) has broad clinical, genetic, and morphologic heterogeneity. Wilkerson and colleagues developed a robust SCC subclassification to describe this variability. They analyzed gene expression arrays from over 400 patients to detect and validate novel gene expression subtypes. The subtypes were found to have significantly different survival outcomes, patient populations, biological processes, and similarities to normal lung cell types. Further, the subtypes stratified heterogeneous SCC into multiple discrete diseases, which could lead to more precise patient prognosis and management, and to advances in basic research.
Fellowships, Grants, Awards
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Fellowships, Grants, Awards Get access JNCI: Journal of the National Cancer Institute, Volume 85, Issue 19, 6 October 1993, Page 1611, https://doi.org/10.1093/jnci/85.19.1611 Published: 06 October 1993
Insanity and the Criminal Law.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Did He Take Something? What Does the Lab Result Mean?
Authors: George D. Lundberg
Journal: JAMA (1982)

A drug may be defined as any chemical that produces an effect when administered to a living organism. As such, there are thousands of substances that can be called drugs. Drug abuse may be defined as use of a drug in a manner that may predictably cause harm. This definition deliberately opposes older and more traditional definitions of drug abuse, since most drug abuse is legal or within existing medical practice. The number of drugs that can be abused is legion since, as Bob Moser used to say, the modern physician's little black bag literally runneth over with various concoctions. One of the most frequent forms of drug abuse is overdose, which may occur with practically any drug. It is a rare hospital emergency physician who does not encounter almost every day patients with known or suspected overdoses. What the physician would like to be able to do when faced
Calmodulin levels in psoriasis—the effect of treatment
Authors: W.F.G. Tucker, S. MacNeil, R.A. Dawson, S. Tomlinson, S.S. Bleehen
Journal: British Journal of Dermatology (1985)

Calmodulin (CaM) is an intracellular calcium binding protein which appears to have an essential modulatory role in a variety of intracellular processes. Levels of CaM in the epidermis in psoriasis have been shown to be elevated in both lesional and non‐lesional skin (Van de Kerkhof & Van Erp, 1983; Tucker et al., 1984). We set out to determine whether successful treatment of psoriasis by standard methods would lead to a parallel reduction in epidermal CaM levels. Seven male and eight female in‐patients, mean age 43 years, with active psoriasis covering between 10% and 75% of the skin surface area were studied. Six patients were treated by a modified Ingram regime, four with methotrexate, two with PUVA and one each with Tigason®, Tigason® plus PUVA, and topical steroids. Epidermal shave biopsies were taken from lesional (15 patients) and non‐lesional (13 patients) forearm skin before commencing treatment and after clearance. The samples were homo genized, their protein content determined, and the CaM content measured using a CaM‐sensitive phosphodiesterase assay. Following treatment there was no significant decrease in CaM levels in the non‐lesional epidermis, the mean CaM levels ± SEM (n) being 0.96 ± 0.23 pre‐treatment and 0.77 ± 0.56 (13) μg CaM per mg epidermal protein, which were only slightly higher than that present in the epidermis of normal volunteers (0.74 ±0.14 (13) μg CaM per mg protein). However, of the lesional samples, those which showed elevated Calmodulin pre‐treatment (nine of the 15 patients) showed a significant decrease in CaM after treatment from 3.22 ± 0.90 to 1.25 ± 0.31 μg CaM per mg protein (P < 0.05). For the remaining six patients CaM levels were within the range for normal volunteers both pre‐ and post‐treatment. These results suggest that elevated CaM levels fall towards the ‘normal’ range with treatment, while there is little change in those skins where the CaM levels are already low.
Chemistry of Food and Nutrition.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P1-07-06: The relationship between Klintrup-Makinen score and cancer-specific survival in primary operable breast cancer
Authors: ES Morrow, F Gujam, ZMA Mohammed, DC McMillan, J Edwards
Journal: Cancer Research (2018)

Abstract Introduction It is increasingly being recognised that cancer prognosis is dependent on a complex interaction of tumour factors and the host response. The degree of inflammatory response at the invasive tumour edge, as measured by the Klintrup-Makinen score, has been shown to have prognostic relevance in some cancers but its role in breast cancer remains unclear. Aim To evaluate the relationship between Klintrup-Makinen score and prognosis in primary operable breast cancer. Methods Patients who underwent surgery for primary operable invasive breast cancer between 1995 and 2007 were studied. Full section haematoxylin and eosin slides from surplus tissue from each breast cancer were analysed. Each was visually scored for the level of inflammatory infiltrate at the invasive edge of the tumour, according to Klintrup-Makinen criteria. Kaplan Meier survival analysis was performed using SPSS. Results 1195 patients were included in the study, of which 298 had a Klintrup-Makinen score (KM) of 0 (no inflammatory cells at the invasive edge), 589 had a score of 1, 238 had a score of 2 and 70 had a Klintrup-Makinen score of 3 (high inflammatory cell infiltrate). 833 (69.7%) patients were ER positive and 172 (14.4%) patients were HER2 positive. Median follow up was 158 months (28-183) and there were 234 cancer deaths. Patients with the highest and lowest KM scores had the best prognosis (10 year breast cancer specific survival (BCSS) 84% for KM score 3 and 82% for KM score 0), while those with KM score 2 had the worst prognosis with 67% 10 year cancer specific survival (p=0.003). When analysed by subtype, in ER negative patients 10 year BCSS was 95% in KM 0 patients, 80% for KM 3, 72% for KM 1 and 67% for KM 2 (p=0.082). Conversely, in HER2 positive patients, the best prognosis was seen in patients with KM 3 with 86% 10 year BCSS but patients with KM 0 had the worst prognosis (BCSS 62%), but this did not reach significance (p=0.544). Conclusion The Klintrup-Makinen score appears to have a prognostic role in primary operable invasive breast cancer, however there is a suggestion that it varies between tumour subtypes. Further work is required to further define this role for each molecular subtype. Citation Format: Morrow ES, Gujam F, Mohammed ZMA, McMillan DC, Edwards J. The relationship between Klintrup-Makinen score and cancer-specific survival in primary operable breast cancer [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P1-07-06.
Neurological and Neurosurgical Conditions Associated With Aviation Safety
Authors: William R. Barclay
Journal: JAMA (1979)

This month the<i>Archives of Neurology</i>is publishing a special issue that deals with the current state of knowledge about selected neurological conditions. This authoritative document was solicited by the Federal Aviation Administration (FAA) to serve as a guide for physicians who examine airman applicants and make decisions concerning medical certifications. The document consists of panel statements on eight categories of major and commonly occurring neurological diseases: (1) cerebrovascular disease, (2) intracranial tumors, (3) head injuries, (4) demyelinating and degenerative diseases, (5) neuromuscular disorders and injuries to the peripheral and cranial nerves and spinal cord, (6) seizure disorders and disturbances of consciousness, (7) migraine and other headaches, and (8) dizziness and disorders of equilibrium. Each panel statement was developed by a group of nationally recognized experts who met in a two-day conference with invited guests and American Medical Association staff to arrive at a consensus. The final document was transmitted
The Care of Patients With AIDS: Don't Ignore the Family Practitioner
Authors: Jill Ginsberg
Journal: JAMA (1989)

<h3>To the Editor.—</h3> We find it disturbing that authors who write about "primary care" of patients with acquired immunodeficiency syndrome (AIDS) neglect family physicians in their discussion of who is or who should be caring for human immunodeficiency virus (HIV)—infected patients. In her recent article, Dr Cotton<sup>1</sup>listed general internists, pediatricians, oncologists, and infectious disease specialists as the physicians who will need to provide the manpower in meeting the challenge of AIDS yet neglected to mention family physicians. Family physicians care for patients in all age groups and are at the forefront of HIV risk-reduction education for patients at all life stages. Testing and counseling are becoming routine in many family practice settings.<sup>2</sup>Family physicians must, at a minimum, know how HIV infection presents in children, in pregnant women, and in adults. In addition, many family physicians continue to care for patients with AIDS and their families throughout
Spontaneous Rupture of Mitral Chordae Tendineae
Authors: Rajindar Singh
Journal: JAMA (1972)

Seven patients with spontaneous rupture of mitral chordae tendineae confirmed by operation had a usual clinical profile consisting of a relatively abrupt onset of pulmonary congestion in a late middle-aged man, a systolic murmur, a vigorously pulsating heart, a normal rhythm, and a slight enlargement of the left atrium. Hemodynamic studies confirmed pulmonary congestion due to large pulmonary capillary v waves, and elevation of left ventricular diastolic pressure, although ventricular contractility in terms of total volume ejected was good. Mitral cusps showed atypical mucoid degeneration with no rheumatic or bacterial involvement. A relationship of this condition to others previously associated with mucoid degeneration of the mitral value is suggested. The cause of this syndrome is still unknown.
Inhibitory Effect of Antiestrogen on Hepatic Tumorigenesis in WF Rats Treated With Diethylstilbestrol Alone or in Combination With &lt;italic&gt;N&lt;/italic&gt;-Nitrosobutylurea&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Chiyo Sumi
 6, Kenjiro Yokoro, Ryotaro Matsushima
Journal: JNCI Journal of the National Cancer Institute (1984)

Four groups of inbred male WF rats were castrated and received sc implantations of diethylstilbestrol [(DES) CAS: 56-53-1; α,α′-diethyl-4,4′-stilbenediol] at 40 days of age. Group I was given no further treatment; groups II and IV were treated with antiestrogen (AntiE) clomiphene citrate simultaneously with DES treatment. At 50–55 days of age, groups III and IV were given drinking water containing N-nitrosobutylurea [(NBU) CAS: 869-01-2; 1-butyl-1-nitrosourea] for 30 days. Castrated male rats or rats castrated and treated with NBU alone developed neither hepatic tumors (HT) nor pituitary tumors (PT). When AntiE was administered, incidences of HT and PT, size and the total number of HT, and mean pituitary weight were significantly reduced in rats given DES alone and in rats given DES with NBU. AntiE treatment changed the distribution in the histologic classification of hepatocellular lesions: Neoplastic nodules, instead of hepato-cellular carcinomas, were predominant. The results indicate that AntiE was effective in the inhibition of hepatic and pituitary tumorigenesis associated with DES treatment. Our previous study has shown that prolactin was not involved in this hepatic tumorigenesis. Therefore, these studies provide evidence that the carcinogenic effect of DES on the liver cell is direct and that HT are regulated in development and growth by AntiE treatment.
Physiological Chemistry: A Text-Book and Manual for Students.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal