tbuckley/cabot-search huggingface dataset:
Drug‐Eluting Porous Embolic Microspheres for Trans‐Arterial Delivery of Dual Synergistic Anticancer Therapy for the Treatment of Liver Cancer
Authors: Benzion Amoyav, Allan I. Bloom, Yoel Goldstein, Rafael Miller, Mariana Sharam, Arnon Fluksman, Ofra Benny
Journal: Advanced Healthcare Materials (2023)

Blockage of blood supply while administering chemotherapy to tumors, using trans-arterial chemoembolization (TACE), is the most common treatment for intermediate and advanced-stage unresectable Hepatocellular carcinoma (HCC). However, HCC is characterized by a poor prognosis and high recurrence rates (≈30%), partly due to a hypoxic pro-angiogenic and pro-cancerous microenvironment. This study investigates how modifying tissue stress while improving drug exposure in target organs may maximize the therapeutic outcomes. Porous degradable polymeric microspheres (MS) are designed to obtain a gradual occlusion of the hepatic artery that nourishes the liver, while enabling efficient drug perfusion to the tumor site. The fabricated porous MS are introduced intrahepatically and designed to release a combination therapy of Doxorubicin (DOX) and Tirapazamine (TPZ), which is a hypoxia-activated prodrug. Liver cancer cell lines that are treated with the combination therapy under hypoxia reveal a synergic anti-proliferation effect. An orthotopic liver cancer model, based on N1-S1 hepatoma in rats, is used for the efficacy, biodistribution, and safety studies. Porous DOX-TPZ MS are very effective in suppressing tumor growth in rats, and induction tissue necrosis is associated with high intratumor drug concentrations. Porous particles without drugs show some advantages over nonporous particles, suggesting that morphology may affect the treatment outcomes.
Beyond acute concussion assessment to office management: a systematic review informing the development of a Sport Concussion Office Assessment Tool (SCOAT6) for adults and children
Authors: Jon S Patricios, Geoff M Schneider, Jacqueline van Ierssel, Laura K Purcell, Gavin A Davis, Ruben J Echemendia, Pierre Fremont, Gordon Ward Fuller, Stanley A Herring, Kimberly G Harmon, Kirsten Holte, Mike Loosemore, Michael Makdissi, Michael McCrea, William P Meehan, Patrick O'Halloran, Zahra Premji, Margot Putukian, Isla Jordan Shill, Michael Turner, Kenzie Vaandering, Nick Webborn, Keith Owen Yeates, Kathryn J Schneider
Journal: British Journal of Sports Medicine (2023)

Objectives To systematically review the scientific literature regarding the assessment of sport-related concussion (SRC) in the subacute phase (3–30 days) and provide recommendations for developing a Sport Concussion Office Assessment Tool (SCOAT6). Data sources MEDLINE, Embase, PsycINFO, Cochrane CENTRAL, CINAHL, SPORTDiscus and Web of Science searched from 2001 to 2022. Data extracted included study design, population, definition of SRC diagnosis, outcome measure(s) and results. Eligibility criteria (1) Original research, cohort studies, case–control studies, diagnostic accuracy and case series with samples &gt;10; (2) SRC; (3) screening/technology that assessed SRC in the subacute period and (4) low risk of bias (ROB). ROB was performed using adapted Scottish Intercollegiate Guidelines Network criteria. Quality of evidence was evaluated using the Strength of Recommendation Taxonomy classification. Results Of 9913 studies screened, 127 met inclusion, assessing 12 overlapping domains. Results were summarised narratively. Studies of acceptable (81) or high (2) quality were used to inform the SCOAT6, finding sufficient evidence for including the assessment of autonomic function, dual gait, vestibular ocular motor screening (VOMS) and mental health screening. Conclusion Current SRC tools have limited utility beyond 72 hours. Incorporation of a multimodal clinical assessment in the subacute phase of SRC may include symptom evaluation, orthostatic hypotension screen, verbal neurocognitive tests, cervical spine evaluation, neurological screen, Modified Balance Error Scoring System, single/dual task tandem gait, modified VOMS and provocative exercise tests. Screens for sleep disturbance, anxiety and depression are recommended. Studies to evaluate the psychometric properties, clinical feasibility in different environments and time frames are needed. PROSPERO registration number CRD42020154787.
What tests and measures accurately diagnose persisting post-concussive symptoms in children, adolescents and adults following sport-related concussion? A systematic review
Authors: Keith Owen Yeates, Anu M Räisänen, Zahra Premji, Chantel T Debert, Pierre Frémont, Sidney Hinds, Jonathan D Smirl, Karen Barlow, Gavin A Davis, Ruben J Echemendia, Nina Feddermann-Demont, Colm Fuller, Isabelle Gagnon, Christopher C Giza, Grant L Iverson, Michael Makdissi, Kathryn J Schneider
Journal: British Journal of Sports Medicine (2023)

Objective To determine what tests and measures accurately diagnose persisting post-concussive symptoms (PPCS) in children, adolescents and adults following sport-related concussion (SRC). Design A systematic literature review. Data sources MEDLINE, Embase, PsycINFO, Cochrane Central Register of Controlled Trials, CINAHL and SPORTDiscus through March 2022. Eligibility criteria Original, empirical, peer-reviewed findings (cohort studies, case-control studies, cross-sectional studies and case series) published in English and focused on SRC. Studies needed to compare individuals with PPCS to a comparison group or their own baseline prior to concussion, on tests or measures potentially affected by concussion or associated with PPCS. Results: Of 3298 records screened, 26 articles were included in the qualitative synthesis, including 1016 participants with concussion and 531 in comparison groups; 7 studies involved adults, 8 involved children and adolescents and 11 spanned both age groups. No studies focused on diagnostic accuracy. Studies were heterogeneous in participant characteristics, definitions of concussion and PPCS, timing of assessment and the tests and measures examined. Some studies found differences between individuals with PPCS and comparison groups or their own pre-injury assessments, but definitive conclusions were not possible because most studies had small convenience samples, cross-sectional designs and were rated high risk of bias. Conclusion The diagnosis of PPCS continues to rely on symptom report, preferably using standardised symptom rating scales. The existing research does not indicate that any other specific tool or measure has satisfactory accuracy for clinical diagnosis. Future research drawing on prospective, longitudinal cohort studies could help inform clinical practice.
Amsterdam 2022 process: A summary of the methodology for the Amsterdam International Consensus on Concussion in Sport
Authors: Kathryn J Schneider, Jon S Patricios, Willem Meeuwisse, Geoff M Schneider, K Alix Hayden, Zahra Premji, Osman Hassan Ahmed, Cheri Blauwet, Steven Broglio, Robert C Cantu, Gavin A Davis, Jiri Dvorak, Ruben J Echemendia, Carolyn A Emery, Grant L Iverson, John J Leddy, Michael Makdissi, Michael McCrea, Michael McNamee, Margot Putukian, Keith Owen Yeates, Amanda M Black, Joel S Burma, Meghan Critchley, Paul H Eliason, Anu M Räisänen, Jason B Tabor, Clodagh Toomey, Paul E Ronksley, J David Cassidy
Journal: British Journal of Sports Medicine (2023)

The purpose of this paper is to summarise the consensus methodology that was used to inform the International Consensus Statement on Concussion in Sport (Amsterdam 2022). Building on a Delphi process to inform the questions and outcomes from the 5th International Conference on Concussion in Sport, the Scientific Committee identified key questions, the answers to which would help encapsulate the current science in sport-related concussion and help guide clinical practice. Over 3½ years, delayed by 2 years due to the pandemic, author groups conducted systematic reviews on each selected topic. The 6th International Conference on Concussion in Sport was held in Amsterdam (27-30 October 2022) and consisted of 2 days of systematic review presentations, panel discussions, question and answer engagement with the 600 attendees, and abstract presentations. This was followed by a closed third day of consensus deliberations by an expert panel of 29 with observers in attendance. The fourth day, also closed, was dedicated to a workshop to discuss and refine the sports concussion tools (Concussion Recognition Tool 6 (CRT6), Sport Concussion Assessment Tool 6 (SCAT6), Child SCAT6, Sport Concussion Office Assessment Tool 6 (SCOAT6) and Child SCOAT6). We include a summary of recommendations for methodological improvements for future research that grew out of the systematic reviews.
Clinical recovery from concussion–return to school and sport: a systematic review and meta-analysis
Authors: Margot Putukian, Laura Purcell, Kathryn J Schneider, Amanda Marie Black, Joel S Burma, Avinash Chandran, Adrian Boltz, Christina L Master, Johna K Register-Mihalik, Vicki Anderson, Gavin A Davis, Pierre Fremont, John J Leddy, David Maddocks, Zahra Premji, Paul E Ronksley, Stanley Herring, Steven Broglio
Journal: British Journal of Sports Medicine (2023)

Objective To define the time frames, measures used and modifying factors influencing recovery, return to school/learn (RTL) and return to sport (RTS) after sport-related concussion (SRC). Design Systematic review and meta-analysis. Data sources 8 databases searched through 22 March 2022. Eligibility criteria Studies with diagnosed/suspected SRC and interventions facilitating RTL/RTS or investigating the time and modifying factors for clinical recovery. Outcomes included days until symptom free, days until RTL and days until RTS. We documented study design, population, methodology and results. Risk of bias was evaluated using a modified Scottish Intercollegiate Guidelines Network tool. Results 278 studies were included (80.6% cohort studies and 92.8% from North America). 7.9% were considered high-quality studies, while 23.0% were considered high risk of bias and inadmissible. The mean days until symptom free was 14.0 days (95% CI: 12.7, 15.4; I 2 =98.0%). The mean days until RTL was 8.3 (95% CI: 5.6, 11.1; I 2 =99.3%), with 93% of athletes having a full RTL by 10 days without new academic support. The mean days until RTS was 19.8 days (95% CI: 18.8, 20.7; I 2 =99.3%), with high heterogeneity between studies. Several measures define and track recovery, with initial symptom burden remaining the strongest predictor of longer days until RTS. Continuing to play and delayed access to healthcare providers were associated with longer recovery. Premorbid and postmorbid factors (eg, depression/anxiety, migraine history) may modify recovery time frames. Though point estimates suggest that female sex or younger age cohorts take longer to recover, the heterogeneity of study designs, outcomes and overlap in CIs with male sex or older age cohorts suggests that all have similar recovery patterns. Conclusion Most athletes have full RTL by 10 days but take twice as long for an RTS. PROSPERO registration number CRD42020159928.
Targeted interventions and their effect on recovery in children, adolescents and adults who have sustained a sport-related concussion: a systematic review
Authors: Kathryn J Schneider, Meghan L Critchley, Vicki Anderson, Gavin A Davis, Chantel T Debert, Nina Feddermann-Demont, Isabelle Gagnon, Kevin M Guskiewicz, K Alix Hayden, Stanley Herring, Corson Johnstone, Michael Makdissi, Christina L Master, Rosemarie Scolaro Moser, Jon S Patricios, Johna K Register-Mihalik, Paul E Ronksley, Noah D Silverberg, Keith Owen Yeates
Journal: British Journal of Sports Medicine (2023)

Objectives We evaluated interventions to facilitate recovery in children, adolescents and adults with a sport-related concussion (SRC). Design Systematic review including risk of bias (modified Scottish Intercollegiate Guidelines Network tool). Data sources MEDLINE(R) and Epub Ahead of Print, In-Process &amp; Other Non-Indexed Citations, Embase, APA PsycINFO, Cochrane Central Register of Controlled Trials, CINAHL Plus with Full Text, SPORTDiscus and Scopus searched until March 2022. Study eligibility criteria (1) Original research including randomised controlled trials (RCTs), quasi-experimental designs, cohort, comparative effectiveness studies; (2) focus on SRC; (3) English; (4) peer-reviewed and (5) evaluated treatment. Results 6533 studies were screened, 154 full texts reviewed and 13 met inclusion (10 RCTs, 1 quasi-experimental and 2 cohort studies; 1 high-quality study, 7 acceptable and 5 at high risk of bias). Interventions, comparisons, timing and outcomes varied, precluding meta-analysis. For adolescents and adults with dizziness, neck pain and/or headaches &gt;10 days following concussion, individualised cervicovestibular rehabilitation may decrease time to return to sport compared with rest followed by gradual exertion (HR 3.91 (95% CI 1.34 to 11.34)) and when compared with a subtherapeutic intervention (HR 2.91 (95% CI 1.01 to 8.43)). For adolescents with vestibular symptoms/impairments, vestibular rehabilitation may decrease time to medical clearance (vestibular rehab group 50.2 days (95% CI 39.9 to 60.4) compared with control 58.4 (95% CI 41.7 to 75.3) days). For adolescents with persisting symptoms &gt;30 days, active rehabilitation and collaborative care may decrease symptoms. Conclusions Cervicovestibular rehabilitation is recommended for adolescents and adults with dizziness, neck pain and/or headaches for &gt;10 days. Vestibular rehabilitation (for adolescents with dizziness/vestibular impairments &gt;5 days) and active rehabilitation and/or collaborative care (for adolescents with persisting symptoms &gt;30 days) may be of benefit.
Child SCAT6
Authors: Gavin A Davis, Ruben J Echemendia, Osman Hassan Ahmed, Vicki Anderson, Cheri Blauwet, Benjamin L Brett, Steven Broglio, Jared M Bruce, Joel S Burma, Gerry Gioia, Christopher C Giza, Kevin M Guskiewicz, Kimberly G Harmon, Stanley A Herring, Michael Makdissi, Christina L Master, Michael McCrea, William P Meehan, Dhiren Naidu, Jon S Patricios, Laura K Purcell, Margot Putukian, Kathryn J Schneider, Tamara C Valovich McLeod, Samuel R Walton, Keith Owen Yeates, Roger Zemek
Journal: British Journal of Sports Medicine (2023)

![Graphic][1]</img> ![Graphic][2]</img> ![Graphic][3]</img> ![Graphic][4]</img> ![Graphic][5]</img> ![Graphic][6]</img> ![Graphic][7]</img> ![Graphic][8]</img> ![Graphic][9]</img> ![Graphic][10]</img> ### Supplementary data [bjsports-2023-106982supp001.pdf] ### Patient consent for publication Not applicable. ### Ethics approval Not applicable. [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif [5]: /embed/inline-graphic-5.gif [6]: /embed/inline-graphic-6.gif [7]: /embed/inline-graphic-7.gif [8]: /embed/inline-graphic-8.gif [9]: /embed/inline-graphic-9.gif [10]: /embed/inline-graphic-10.gif
The Concussion Recognition Tool 6 (CRT6)
Authors: Ruben J Echemendia, Osman Hassan Ahmed, Christopher M Bailey, Jared M Bruce, Joel S Burma, Gavin A Davis, Gerry Gioia, David R Howell, Gordon Ward Fuller, Christina L Master, Jacqueline van Ierssel, Jamie Pardini, Kathryn J Schneider, Samuel R Walton, Roger Zemek, Jon S Patricios
Journal: British Journal of Sports Medicine (2023)

![Graphic][1]</img> ![Graphic][2]</img> ### Patient consent for publication Not applicable. ### Ethics approval Not applicable. [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif
Introducing the Sport Concussion Office Assessment Tool 6 (SCOAT6)
Authors: Jon S Patricios, Gavin A Davis, Osman Hassan Ahmed, C Blauwet, Geoff M Schneider, Laura K Purcell, Ruben J Echemendia, Pierre Fremont, Gordon Ward Fuller, Stanley A Herring, Kimberly G Harmon, Mike Loosemore, Michael Makdissi, Patrick O'Halloran, Margot Putukian, Michael Turner, Nick Webborn, Keith Owen Yeates, Jacqueline van Ierssel, Kathryn J Schneider
Journal: British Journal of Sports Medicine (2023)
Sport Concussion Assessment Tool 6 (SCAT6)
Authors: Ruben J Echemendia, Benjamin L Brett, Steven Broglio, Gavin A Davis, Christopher C Giza, Kevin M Guskiewicz, Kimberly G Harmon, Stanley Herring, David R Howell, Christina Master, Michael McCrea, Dhiren Naidu, Jon S Patricios, Margot Putukian, Samuel R Walton, Kathryn J Schneider, Joel S Burma, Jared M Bruce
Journal: British Journal of Sports Medicine (2023)

![Graphic][1]</img> ![Graphic][2]</img> ![Graphic][3]</img> ![Graphic][4]</img> ![Graphic][5]</img> ![Graphic][6]</img> ![Graphic][7]</img> ![Graphic][8]</img> ![Graphic][9]</img> ### Supplementary data [bjsports-2023-107036supp001.pdf] ### Patient consent for publication Not applicable. ### Ethics approval Not applicable. [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif [5]: /embed/inline-graphic-5.gif [6]: /embed/inline-graphic-6.gif [7]: /embed/inline-graphic-7.gif [8]: /embed/inline-graphic-8.gif [9]: /embed/inline-graphic-9.gif
Examining later-in-life health risks associated with sport-related concussion and repetitive head impacts: a systematic review of case-control and cohort studies
Authors: Grant L Iverson, Rudolph J Castellani, J David Cassidy, Geoff M Schneider, Kathryn J Schneider, Ruben J Echemendia, Julian E Bailes, K Alix Hayden, Inga K Koerte, Geoffrey T Manley, Michael McNamee, Jon S Patricios, Charles H Tator, Robert C Cantu, Jiri Dvorak
Journal: British Journal of Sports Medicine (2023)

Objective Concern exists about possible problems with later-in-life brain health, such as cognitive impairment, mental health problems and neurological diseases, in former athletes. We examined the future risk for adverse health effects associated with sport-related concussion, or exposure to repetitive head impacts, in former athletes. Design Systematic review. Data sources Search of MEDLINE, Embase, Cochrane, CINAHL Plus and SPORTDiscus in October 2019 and updated in March 2022. Eligibility criteria Studies measuring future risk (cohort studies) or approximating that risk (case-control studies). Results Ten studies of former amateur athletes and 18 studies of former professional athletes were included. No postmortem neuropathology studies or neuroimaging studies met criteria for inclusion. Depression was examined in five studies in former amateur athletes, none identifying an increased risk. Nine studies examined suicidality or suicide as a manner of death, and none found an association with increased risk. Some studies comparing professional athletes with the general population reported associations between sports participation and dementia or amyotrophic lateral sclerosis (ALS) as a cause of death. Most did not control for potential confounding factors (eg, genetic, demographic, health-related or environmental), were ecological in design and had high risk of bias. Conclusion Evidence does not support an increased risk of mental health or neurological diseases in former amateur athletes with exposure to repetitive head impacts. Some studies in former professional athletes suggest an increased risk of neurological disorders such as ALS and dementia; these findings need to be confirmed in higher quality studies with better control of confounding factors. PROSPERO registration number CRD42022159486.
Consensus statement on concussion in sport: the 6th International Conference on Concussion in Sport–Amsterdam, October 2022
Authors: Jon S Patricios, Kathryn J Schneider, Jiri Dvorak, Osman Hassan Ahmed, Cheri Blauwet, Robert C Cantu, Gavin A Davis, Ruben J Echemendia, Michael Makdissi, Michael McNamee, Steven Broglio, Carolyn A Emery, Nina Feddermann-Demont, Gordon Ward Fuller, Christopher C Giza, Kevin M Guskiewicz, Brian Hainline, Grant L Iverson, Jeffrey S Kutcher, John J Leddy, David Maddocks, Geoff Manley, Michael McCrea, Laura K Purcell, Margot Putukian, Haruhiko Sato, Markku P Tuominen, Michael Turner, Keith Owen Yeates, Stanley A Herring, Willem Meeuwisse
Journal: British Journal of Sports Medicine (2023)

For over two decades, the Concussion in Sport Group has held meetings and developed five international statements on concussion in sport. This 6th statement summarises the processes and outcomes of the 6th International Conference on Concussion in Sport held in Amsterdam on 27-30 October 2022 and should be read in conjunction with the (1) methodology paper that outlines the consensus process in detail and (2) 10 systematic reviews that informed the conference outcomes. Over 3½ years, author groups conducted systematic reviews of predetermined priority topics relevant to concussion in sport. The format of the conference, expert panel meetings and workshops to revise or develop new clinical assessment tools, as described in the methodology paper, evolved from previous consensus meetings with several new components. Apart from this consensus statement, the conference process yielded revised tools including the Concussion Recognition Tool-6 (CRT6) and Sport Concussion Assessment Tool-6 (SCAT6, Child SCAT6), as well as a new tool, the Sport Concussion Office Assessment Tool-6 (SCOAT6, Child SCOAT6). This consensus process also integrated new features including a focus on the para athlete, the athlete's perspective, concussion-specific medical ethics and matters related to both athlete retirement and the potential long-term effects of SRC, including neurodegenerative disease. This statement summarises evidence-informed principles of concussion prevention, assessment and management, and emphasises those areas requiring more research.