tbuckley/cabot-search huggingface dataset:
RHODE ISLAND MEDICAL SOCIETY.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diabetic Neuropathy
Authors: Zachary T. Bloomgarden
Journal: Diabetes Care (2007)

Perspectives on the News commentaries are now part of a new, free monthly CME activity. The Mount Sinai School of Medicine, New York, New York, is designating this activity for 2.0 AMA PRA Category 1 credits. If you wish to participate, review this article and visit www.diabetes.procampus.net to complete a posttest and receive a certificate. The Mount Sinai School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
The influence of reference vessel diameter on angiographic restenosis and target vessel revascularization in gamma radiation versus placebo for in-stent restenosis Andrew E. Ajani, Ron Waksman, Roxana Mehran, Alexandra J. Lansky, Lowell F. Satler, Augusto D. Pichard, Kenneth M. Kent. Washington Hospital Center, Washington, DC
Journal: Journal of the American College of Cardiology (2001)
Medical Consultation: The Internist on Surgical, Obstetric, and Psychiatric Services
Authors: Lawrence E. Klein
Journal: JAMA (1991)

It was a little over a decade ago that the topic of medical consultation took on a life of its own as a distinct "subspecialty" within the realm of general internal medicine. In particular, an article by Goldman et al<sub>1</sub>in 1977 and several presentations at national medical meetings in the early 1980s presaged the appearance of four textbooks of medical consultation in 1982 and 1983. All represented valuable additions to the medical literature. Since my overall favorite was the text by Kammerer and Gross, I was especially interested to review the new edition of their book. Wisely, Kammerer and Gross chose to pattern this second edition closely upon their successful first edition. A review of the table of contents reveals the overall organization to be almost identical to that of the first edition. However, three new chapters have been added, and the overall length of the book has
Infant Mortality In Socially Vulnerable Populations
Authors: W. Nersesian
Journal: Annual Review of Public Health (1988)

Studies have shown for decades that certain subpopulations of infants, for example, those in poverty and in certain minority groups, are at substantially higher risk for illness and death than the national average. If mothers and infants of these "vulnerable populations" were as healthy as their "nonvulnerable" counterparts, as many as one third (approximately 12,000 deaths) of all infant deaths in the United States might be avoided each year. This paper is intended to document which infants are vulnerable, to quantitate the degree of risk where possible, and to outline potential changes in public policy that may lead to improvements in the health of these infants.
In This Issue
Journal: Circulation Research (2012)

RyRS2808 Is Irrelevant to Heart Failure (p 831)Zhang et al find no role for calcium channel phosphorylation in heart failure, but a controversy continues.Progressive damage after myocardial infarction can ultimately lead to arrhythmias, heart failure, and sudden death.Although it is known that dysregulation of calcium in cardiomyocytes exacerbates the pathophysiology of heart failure, the underlying cause of this dysregulation is not yet entirely clear.Some studies suggest that hyperphosphorylation of RyR2, a calcium channel found in the sarcoplasmic reticulum of heart cells, leads to aberrant calcium release.Studies also suggest that mice carrying a version of RyR2 that could not be phosphorylated are protected against heart failure.Other reports, however, found no such causative link.Here, Zhang et al provide further evidence that no such link exists.They studied mice carrying the nonphosphorylatable RyR2 and found they were not protected from heart failure after myocardial infarction.The mice had similarly sized infarct regions and decreased pump activity, similar to that of wild-type mice.Molecular changes and electrophysiological properties of cardiac myocytes isolated from these mice also were similar.The authors cannot explain why they found such strikingly different results, but they suggest that the genetic background of the mice used in the different experiments might be responsible.
Z Immun Forsch, Allerg &amp;amp; Klin Immun, Stuttgart
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Venom Immunotherapy
Authors: Robert E. Reisman
Journal: JAMA (1980)

<h3>To the Editor.—</h3> The article entitled "Allergists Who Alarm the Public" (243:793, 1980) is an affront to the integrity of the practicing allergist. To suggest an "alarmist" attitude or unethical behavior by any physician without careful and specific documentation and, in particular, to extend such accusations to groups of established clinical investigators who recommend venom immunotherapy as an effective form of treatment is objectionable. Substantial advances have been made in the understanding of allergic reactions and immunity to stinging insects in recent years. With increasing knowledge, further complexities have been uncovered. Howard S. Rubenstein, MD, has alluded to several of these problems—the natural history of sensitivity and selection of patients at risk who may require specific venom immunotherapy. Allergists are aware of these problems, perhaps more so because of the high cost of immunotherapy. Current controversies and unresolved issues have been thoroughly discussed in recent publications,<sup>1-3</sup>at numerous regional
Furnace-Generated Acid Aerosols: Speciation and Pulmonary Effects
Authors: Mary O. Amdur, Lung Chi Chen
Journal: Environmental Health Perspectives (1989)

Guinea pigs were exposed to ultrafine aerosols (less than 0.1 micron) of zinc oxide with a surface layer of sulfuric acid. These acid-coated aerosols are typical of primary emissions from smelters and coal combustors. Repeated daily 3-hr exposures for 5 days produce decrements in lung volumes and pulmonary diffusing capacity and elevations of lung weight/body weight ratio, protein, and number of neutrophils in pulmonary lavage fluid at concentrations of 20 micrograms/m3. A single 1-hr exposure to 20 micrograms/m3 causes increased bronchial reactivity. Higher concentrations of conventionally generated sulfuric acid mist are required to produce responses of similar magnitude.
NEW SOURCES OF MEDICAL HISTORY
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Plasma Cell Proliferative Index Is an Independent Predictor of Progression in Smoldering Multiple Myeloma
Authors: Mohammed A Aljama, M Hasib Sidiqi, Arjun Lakshman, Angela Dispenzieri, Dragan Jevremovic, Morie A. Gertz, Martha Q. Lacy, Francis K. Buadi, David Dingli, Eli Muchtar, Amie Fonder, Suzanne R. Hayman, Miriam Hobbs, Wilson I Gonsalves, Rahma Warsame, Taxiarchis Kourelis, Lisa Hwa, Prashant Kapoor, Nelson Leung, Ronald S. Go, Robert A. Kyle, S. Vincent Rajkumar, Shaji K. Kumar
Journal: Blood (2018)
Skin biopsy
Authors: P. C. Anderson
Journal: JAMA (1967)

With the exception of blood, no human living tissue can be secured more easily or safely for cytologic study than can skin.<sup>1-5</sup>Our problem becomes then not how to biopsy the skin, but where, when, and why to biopsy, and, most important, what useful information we can expect from the pathologist's report. <h3>How.—</h3> The decision to biopsy made, a surgical tray is assembled containing a scalpel with a No. 15 blade, fine surgical pickups, appropriate 4-0 or 5-0 silk or nylon suture with the needle attached, a small needle holder, and six to a dozen 4 × 4-inch surgical sponges. Available in separate sterile packages are curved mosquito hemostats, which are used mainly for dissection because hemostasis of the biopsy wound generally can be secured by steady gentle pressure for three minutes by the clock. Skin punches of various sizes, small skin hooks, and an iris scissors are useful
Evaluation of meaningful change in bowel movement frequency for patients with carcinoid syndrome.
Authors: Stacie Hudgens, Jonathon Gable, Matthew H. Kulke, Emily Bergsland, Lowell Brian Anthony, Martyn E. Caplin, Kjell E. Oberg, Marianne Pavel, Phillip Banks, Qi Melissa Yang, Pablo Lapuerta
Journal: Journal of Clinical Oncology (2017)

e15132 Background: Telotristat ethyl is a tryptophan hydroxylase inhibitor in development for the treatment of carcinoid syndrome (CS) in patients who receive somatostatin analog (SSA) therapy. In TELESTAR, a pivotal Phase 3 study, telotristat ethyl significantly reduced bowel movement (BM) frequency compared to placebo. The objective of this study was to psychometrically assess meaningful change in BM frequency using data collected within the TELESTAR study. Methods: An anchor-based approach consisted of mapping change from baseline in BM frequency to other patient reported assessments of change. These included the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire - Core Questionnaire (EORTC QLQ-C30) Diarrhea Symptom responders, the EORTC GI.NET21 GI Symptom responders, and patient reported adequate relief at Week 12 (responders had a ≥ 10-point decrease in scores from Day 1 to Week 12). Parameters included within group mean change from baseline to Week 12, t-tests of the change (Wilcoxon Rank Sum for adequate relief), effect size (ES: calculated as the difference between mean on-treatment and baseline BM frequency, divided by the standard deviation of the baseline), and related confidence intervals. Results: There were 135 patients with CS, with a mean age of 63.6 years and mean baseline BM frequency of 5.7 BM/day. Anchor-based analyses indicated significant differences in BM frequency between adequate relief groups at Week 12 (ES: −1.58 vs. −0.79; p = 0.014), responders and non-responders on the EORTC QLQ-C30 Diarrhea Symptoms domain (ES: −1.24 vs. −0.59; p &lt; 0.0001), and responders and non-responders on the EORTC GI.NET21 GI Symptoms Domain (ES: −1.49 vs. −0.75; p = 0.0053). These corresponded to BM frequency reductions of 1.7–1.9 BM/day, or ≥ 30%. Conclusions: Results of this study indicated that patients with CS experienced clinically meaningful reductions in BM frequency of ≥ 30% over the course of 12 weeks. Clinical trial information: NCT01677910.
Counselling patients before an HIV test.
Journal: BMJ (1991)

took a study of 2600 seafarers working with Belgian shipping companies.Of 336 screening tests, 15 (4-5%) yielded a positive result.This is extremely high, the average prevalence of HIV infection among Belgians being 0062%.3Thus, like prisoners, seafarers require management, treatment, education, and information is tailored to their circumstances.They need to be targeted as they pose complex logistical problems with regard to decreasing their risk.
What to Tell the Public About Health: A Collection of Short Articles Aimed to Present in Simple Terms the Facts About the Prevention of Disease and the Promotion of Health.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DIET IN FEVER.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Induced sputum cell profiles in lung transplant recipients with or without chronic rejection: correlation with lung function
Authors: K M Beeh, O Kornmann, J Lill, R Buhl
Journal: Thorax (2001)

BACKGROUND Sputum induction is a non-invasive procedure for measuring inflammatory processes of the lower respiratory tract. The aim of this study was to establish sputum cell counts and differentials in patients after lung transplantation (LTx), with or without chronic transplant rejection. METHODS Sputum induction was performed in 41 LTx patients (25 single LTx (sLTx), 16 double LTx (dLTx) and 15 healthy non-smoking volunteers. Sputum was processed according to standard protocols. Total cell count was calculated as mean (SE) cells × 10 6 /ml sputum and cell differential (%) was evaluated after staining. Cellular profiles were correlated with lung function. RESULTS Total sputum cell counts were increased in sLTx (9 (1.9) cells × 10 6 /ml, p=0.01) and dLTx patients (7.2 (1.5) × 10 6 /ml, p=0.01) compared with healthy controls (2.6 (0.6) × 10 6 /ml). There was also a marked sputum neutrophilia in both patient groups (59 (6)% and 62 (6)%, respectively, p&lt;0.001 v controls). Moreover, in both sLTx and dLTx patients with chronic transplant rejection there was an increased number of sputum neutrophils compared with patients with normal graft function (p&lt;0.05 both comparisons), and neutrophils were inversely correlated with lung function (forced expiratory volume in one second (FEV 1 ) % predicted): sLTx, r =–0.61, p=0.001; dLTx, r =–0.75, p=0.001, respectively). Sputum lymphocytes and eosinophils were similar in both groups. No relevant side effects occurred during sputum induction. CONCLUSIONS Sputum induction is a safe and non-invasive tool for monitoring lower respiratory tract inflammation in LTx patients. Both sLTx and dLTx patients with chronic rejection had increased sputum neutrophils compared with patients with normal transplant function. These data support findings of other authors highlighting a possible role for neutrophils in the pathogenesis of chronic transplant rejection.
Nicotine Inhibits Anticoagulant Actions of Heparin
Journal: JAMA (1963)

The lipid-clearing, anticoagulant actions of heparin, a sulfated mucopolysaccharide, can be inhibited by nicotine, according to Dr. Harold J. White of the Veterans Administration Hospital in Roxbury, Mass. In a paper "The Antagonism Between Nicotine and Heparin Activity," White observed that in white rats, injected with nicotine followed by heparin (and in reverse order), the normal lipid-clearing action of heparin decreased. In addition, the presence of nicotine inhibited the anticoagulant qualities of heparin, he said. When added to the blood, nicotine both accelerated (when present in minute amounts) and prolonged (when present in larger amounts) the normal clotting time. The accelerating effect could be reversed by prior incubation of nicotine with heparin. White's two-part study proceeded along these lines: <h3>In vitro.—</h3> Post-heparinized rat plasma (.5 ml) was incubated for one hour with varying amounts of nicotine in a commercial emulsion. The clearing factor activity (CFA) was measured as optical density
Enforcing patient preferences. Linking payment for medical care to informed consent
Authors: M. B. Kapp
Journal: JAMA (1989)

The legal and ethical doctrine of informed consent is well accepted in modern medicine. Nonetheless, medical interventions sometimes take place in the absence of informed consent, particularly in the case of life-sustaining medical procedures. These procedures ordinarily are reimbursed by third-party payers. This article proposes as a strategy to ensure greater attention to patient preferences in medical decision making that financial reimbursement for each medical service be linked to a requirement of valid patient (or surrogate) consent to the service involved. Utilization review bodies could monitor informed consent in the same way that other aspects of necessity, appropriateness, and quality are now monitored. (<i>JAMA</i>. 1989;261:1935-1938)
The safety of aspartame
Authors: W. M. Pardridge
Journal: JAMA (1986)

<h3>To the Editor.—</h3> The American Medical Association Council on Scientific Affairs recently reviewed aspartame safety issues.<sup>1</sup>Aspartame is a new dipeptide sweetener, and US consumption of aspartame within three years of its widespread introduction into the food supply has increased to levels that, after normalization for sweetener potency, are approximately 10% of overall sugar intake.<sup>2</sup>It is reasonable to expect that the consumption of aspartame may approach 25% of overall sugar consumption by the 1990s. Given the widespread use of this elective food additive and given that its two constituent amino acids, aspartic acid and phenylalanine, are neurotoxic, it is indeed prudent to consider safety issues in regard to the potential effects of this sweetener. Since neurotoxicity is a function of the blood level achieved following consumption of the sweetener and since blood aspartate levels do not rise after aspartame intake, it appears unlikely that there will be
Diabetes Mellitus.
Authors: James A. Hopkins
Journal: JAMA (1898)

Milton, Del., Dec. 28, 1897. <h3>To the Editor:</h3> —In theJournalof Dec. 18, 1897, you gave us quite an elaborate article on "Diabetes Mellitus," for which the profession owes you many thanks. I have often thought while the scientists were almost turning the world over to unearth a remedy for the cure of consumption, diphtheria, etc., how little has been done about this dread disease. There are reasons for it, and one is they have never satisfactorily solved the why and wherefore, the primary cause; but why has there not been more investigation? For, if there is one disease more loathsome than another it must be diabetes. It deserves our most thoughtful and serious consideration. The authors give us but a faint idea of the disease or how or whence it comes. They speak of sugar appearing in the urine after eating certain kinds of food, or it may
Pyrotinib Tops Lapatinib in Metastatic Breast Cancer
Journal: Cancer Discovery (2019)

Abstract A Chinese study of patients with HER2-positive metastatic breast cancer shows that the HER2 inhibitor pyrotinib increases progression-free survival and objective response rates over lapatinib. Pyrotinib did increase the incidence of side effects such as diarrhea and hand–foot syndrome. However, about 54% of trial participants had previously taken trastuzumab, so the study's results may not hold true in the United States, where most patients receive it.