tbuckley/cabot-search huggingface dataset:
Assessment of Regional Cytochrome P450 Activities in Rat Liver Slices Using Resorufin Substrates and Fluorescence Confocal Laser Cytometry
Authors: John T. Heinonen, Jaspreet S. Sidhu, Maureen T. Reilly, Federico M. Farin, Curtis J. Omiecinski, David L. Eaton, Terrance J. Kavanagh
Journal: Environmental Health Perspectives (1996)

Characterizing constitutive activities and inducibility of various cytochrome P450 isozymes is important for elucidating species and individual differences in susceptibility to many toxicants. Although expression of certain P450s has been studied in homogenized tissues, the ability to assess functional enzyme activity without tissue disruption would further our understanding of interactive factors that modulate P450 activities. We used precision-cut, viable rat liver slices and confocal laser cytometry to determine the regional enzyme activities of P450 isozymes in situ. Livers from control and beta-naphthoflavone (beta NF)-treated rats were sectioned with a Krumdieck tissue slicer into 250-microns thick sections. A slice perfusion chamber that mounts on the cytometer stage was developed to allow for successive measurement of region-specific P450-dependent O-dealkylation of 7-ethoxy-, 7-pentoxy-, and 7-benzyloxyresorufin (EROD, PROD, and BROD activity, respectively) in the same liver slice. Images of the accumulated fluorescent resorufin product within the tissue were acquired using a confocal laser cytometer in confocal mode. As expected, slices isolated from beta NF-treated rats showed high levels of centrilobular EROD activity compared to slices from control rats, whereas PROD and BROD activities remained at control levels. These techniques should allow for the accurate quantification of regional and cell-specific P450 enzyme activity and, with subsequent analysis of the same slice, the ability to correlate specific P450 mRNAs or other factors with enzymatic activity. Moreover, these techniques should be amenable to examination of similar phenomena in other tissues such as lung and kidney, where marked heterogeneity in cellular P450 expression patterns is also known to occur.
Errors in Methods, Results, Table 1, Figure 2, and Supplement
Journal: JAMA Network Open (2019)

Wei-Hsuan Lo-Ciganic, PhD; James L. Huang, PhD; Hao H. Zhang, PhD; Jeremy C. Weiss, MD, PhD; Yonghui Wu, PhD; C. Kent Kwoh, MD; Julie M. Donohue, PhD; Gerald Cochran, PhD; Adam J. Gordon, MD, MPH; Daniel C. Malone, PhD; Courtney C. Kuza, PhD; Walid F. Gellad, MD, MPH
Obstetrical Accidents, Emergencies and Operations
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AGE AND WORK.
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P2.09-32 Higher Prevalence of EGFR Mutations Significantly Correlates with Lower PD-L1 Expression in Chinese Lung Adenocarcinoma
Authors: S. Wen, Y. Jiang, J. Guo, X. Fan, X. Pan, Y. Dai, D. Chen, K. Wang, X. Dong, S. Zhang
Journal: Journal of Thoracic Oncology (2019)
<i>Errata</i>: Vol. 65, No. 28
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

In the MMWR report, "Projected Zika Virus Importation and Subsequent Ongoing Transmission after Travel to the 2016 Olympic and Paralympic Games - Country-Specific Assessment, July 2016," an error occurred throughout in reporting the number of countries participating in the 2016 Olympic and Paralympic Games without evidence of past Zika transmission: 18 countries (not 19 as stated) met this criterion. Thus, the fourth sentence of the fourth paragraph should have read, "For 14 of these countries, estimated aviation travel from Rio de Janeiro in August 2016 compared with total aviation travel from all countries with local Zika virus transmission in 2015 was 0.01%-3.04% (Table 2)." In addition, in Table 2, Angola should not have been listed, and the title should have read, "Participating countries currently not reporting Zika outbreaks (n = 18) that met risk criteria for Zika virus importation and subsequent ongoing transmission attributed to travel to the Olympic and Paralympic Games, ranked by aviation travel volume* from Rio de Janeiro, Brazil - August 2016."
Gigiena i Sanitaria, Moscow
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Binding of Aromatic Amines to the Rat Hepatic Ah Receptor In Vitro and In Vivo and to the 8S and 4S Estrogen Receptor of Rat Uterus and Rat Liver
Authors: Peter Cikryt, Thomas Kaiser, Martin Gottlicher
Journal: Environmental Health Perspectives (1990)

Studies on structurally related aromatic amines with different carcinogenic properties have shown that 2-acetylaminofluorene (2-AAF) and 2-acetylaminophenanthrene (AAP) inhibit the binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the Ah receptor in vitro. The apparent inhibitor constants (Ki) are 2.3 microM for 2-AAF and 2.7 microM for AAP. In contrast, 4-acetylaminofluorene, an isomer of 2-AAF, and trans-4-acetylaminostilbene do not bind to the rat hepatic cytosolic Ah receptor. Pretreating female Wistar rats with 2-AAF or AAP leads to the induction of the P-450 isoenzymes that are under the control of the Ah receptor. Ornithine decarboxylase activity is induced by all aromatic amines tested irrespective of their Ah receptor affinity. The aromatic amines used as model compounds do not inhibit the binding of 17-beta-estradiol to the 8S and 4S estrogen receptor of rat uterus or rat liver in a competition assay analyzed using sucrose density gradient centrifugation. On the other hand, the aromatic amines bind to varying extents to another estrogen-binding protein of rat liver whose function and identity is still unknown. Our study demonstrates that structurally related aromatic amines in their unmetabolized form interact differentially with a cellular target protein, the Ah receptor, in vitro as well as in vivo. However, a relationship between these effects and the postulated promoting properties of 2-AAF remains to be established.
Diapers and poisons
Authors: B. H. Rumack
Journal: JAMA (1982)

Those of us with experience in childhood poisoning have published numerous articles dealing with series of cases related to a single intoxicant. While these series and others that show various epidemiologic data abound in the literature and in textbooks, few articles deal with practical poison prevention. We usually include a paragraph or two on prevention in review articles or general poisoning principles. Some hazardous household areas may even be pointed out. Specific data for these areas are usually related to where the products are thought to be found—garages, kitchen sinks, laundry rooms, or medicine cabinets. The clear-cut data by McCormick et al (p 2159) show us that wherever diaper changing is done must be classified as potentially hazardous. The article was done looking specifically at the area and not by looking at the products and surmising where they might have been located. Reasons for a certain area being high risk
<i>Shigella sonnei</i>Outbreak Among Men Who Have Sex With Men—San Francisco, California, 2000-2001
Journal: JAMA (2002)

Shigella sonnei causes approximately 10,000 cases of gastroenteritis each year in the United States. These infections occur predominately among young children and usually are associated with poor hygienic conditions in child-care settings. Outbreaks of shigellosis among men who have sex with men (MSM) have occurred because of direct or indirect oral-anal contact but usually are caused by Shigella flexneri. This report describes an investigation of S. sonnei cases that occurred among MSM in San Francisco during May-December 2000. Following efforts to heighten awareness, the number of cases has declined, but new cases continue to occur at low levels in this risk group (Figure 1). The increased incidence of sexually transmitted Shigella and other sexually transmitted diseases (STDs) in MSM require renewed and innovative prevention efforts.
MESENTERIC VASCULAR OCCLUSION WITH RECOVERY
Authors: John R. Green
Journal: JAMA (1934)

<h3>[Note.—</h3> This suggestion was forwarded to Dr. J. R. Green, who replies:] <h3>To the Editor:—</h3> The criticism is pertinent. We have no positive proof of the etiology in this case. Reference to the description of the gangrenous bowel that it was a straightened out piece of bowel lying parallel to the mesentery on the left side of the spinal column, with no kinking of the mesentery and no adhesions of the gangrenous bowel or any adjacent bowel or other viscera, makes it improbable that volvulus could have caused the interruption of the blood supply. The patient had no symptoms referable to the gastro-intestinal tract during the eight months interval between the appendectomy and the onset of the gangrenous bowel. Two weeks before the onset of this disease the patient and three other persons took an automobile tour of several hundred miles. One other member of the party had acute appendicitis
Phase II study of 6-thioguanine, procarbazine, dibromodulcitol, lomustine, and vincristine chemotherapy with radiotherapy for treating malignant glioma in children
Authors: V.A. Levin, Kathleen Lamborn, William Wara, Richard Davis, Michael Edwards, Jane Rabbitt, Mary Malec, Michael D. Prados
Journal: Neuro-Oncology (2000)

Neuro-OncologyWe conducted a single-arm phase II study to evaluate the ef cacy and safety of radiotherapy combined with 6-thioguanine, procarbazine, dibromodulcitol, lomustine, and vincristine (TPDCV) chemotherapy for treating malignant astrocytoma in children and anaplastic ependymoma in patients of all ages.Between 1984 and 1992, 42 patients who had malignant astrocytomas (glioblastomas multiforme, anaplastic astrocytomas, or mixed anaplastic oligoastrocytomas) were treated with TPDCV chemotherapy and radiation therapy.Of these patients, 40 were younger than 18 years, but 2 were older (22 and 23 years) when treated.Cranial radiation averaged 58 Gy.TPDCV chemotherapy was given for 1 year or until progression.Between 1989 and 1991, 17 patients with malignant ependymoma were treated with TPDCV chemotherapy and craniospinal radiation.Radiation was given at an average dose of 54 Gy to the tumor, 28 Gy to the whole brain, and 31 Gy to the spinal axis.TPDCV chemotherapy was given for 1 year or until tumor progressed.Of the patients with glioblastoma multiforme, 13 of 17 died; the median time to progression was 49 weeks, and median survival was 85 weeks.The four patients surviving at this writing were followed a median 537 weeks (range 364-635 weeks).Of the patients with nonglioblastoma malignant astrocytoma, 14 of 25 died; the median time to progression was 224 weeks.Median survival was not reached in this group.The median follow-up for those surviving was 494 weeks.For the patients with ependymoma, 11 of 17 died with a median time to progression of 141 weeks.The median follow-up for the eight who survive was 469 weeks.Nine patients died with a median survival of 183 weeks.The combination of TPDCV and radiotherapy has activity against childhood anaplastic astrocytoma, glioblastoma multiforme, and anaplastic ependymoma.The results of this study for children with glioblastoma were comparable to results in the literature, while the results for children with anaplastic astrocytoma appeared better than most reports.The combination of TPDCV chemotherapy and radiation therapy for anaplastic ependymomas appears to be active and at least as good as published reports using radiation therapy alone.
Children and families need help after disasters
Authors: L. Lamberg
Journal: JAMA (1996)

WACO, Oklahoma City, Dunblane... Among the most poignant images stirred by these tragedies are those of children as both victims and survivors. Speakers at the annual meeting of the American Psychiatric Association (APA) discussed the aftermath of violence and the role of mental health services in helping children in these communities. <h3>Waco</h3> When 21 children, from 5 months to 12 years old, were released from the Branch Davidian compound over a 3-day period, state child protective services staff initially intended individual foster care placements. But the children were traumatized by having been in a shootout and taken from the world they knew, however flawed, reported Bruce Perry, MD, PhD, vice chair for research, Department of Psychiatry, and director of the CIVITAS ChildTrauma Programs at Baylor College of Medicine, Houston, Tex. Perry's team and the Federal Bureau of Investigation wanted to keep them together. A cottage was made available at the
The Public Health Nurse in Action
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMERICAN MEDICAL ASSOCIATION.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lord Cohen of Birkenhead dead
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Orderly Process of Sequential Cytokine Stimulation Is Required for Activation and Maximal Proliferation of Primitive Human Bone Marrow CD34+ Hematopoietic Progenitor Cells Residing in G0
Authors: Amy C. Ladd, Robert Pyatt, Andre Gothot, Susan Rice, Jon McMahel, Christie M. Traycoff, Edward F. Srour
Journal: Blood (1997)
Realities, Myths
Authors: Nelson Borelli
Journal: JAMA (1985)

<h3>To the Editor.—</h3> Dr Glass' strong, personal response<sup>1</sup>to the COMMENTARY I wrote entitled "Abolition Not Reform"<sup>2</sup>leaves me with mixed feelings of being both honored and scolded. Perhaps the best immediate reaction for me is to join in his praise ofThe Journalfor its "valuable service." Now, let's turn to the realities and myths. Dr Glass is right, I do not deal with "difficult problems embodied in the insanity defense." How can I when I agreed with the AMA House of Delegates endorsement for abolishing the insanity defense?<sup>3</sup>It does not belong in medicine. Many of us wonder to what extent lawyers, politicians, and social engineers are responsible for fostering the creation and maintenance of the insanity defense. Dr Glass probably believes I do not deal with the social and legal issues related to the alleged criminal. Those issues, however, are realities, big ones, that
Temporary Connection
Authors: Charles K. Morris
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal