tbuckley/cabot-search huggingface dataset:
Estrogen receptors, progesterone receptors and heat-shock 27-kD protein in liver biopsy specimens from patients with hepatitis B virus infection
Authors: D Ciocca
Journal: Hepatology (1991)

It has been proposed that in the human liver, the estrogen receptor gene may become inappropriately expressed as a consequence of HBV integration, contributing to cell transformation. This study was undertaken to examine estrogen receptor status in patients with hepatitis B virus infection and to analyze the expression of progesterone receptor and of a heatshock 27,000-D protein (hsp27), both of which are estrogen regulated in estrogen target tissues. Receptor proteins were detected in liver biopsy specimens by immunocytochemistry using antireceptor monoclonal antibodies; a monoclonal antibody was also used to detect hsp27. Estrogen receptor and progesterone receptor were mainly seen in the nuclei of hepatocytes. The presence of hepatitis B virus infection did not always result in elevated estrogen receptor expression, but in general the expression of this receptor protein was higher in hepatitis B virus–positive patients than in patients with the same pathological findings (hepatitis, cirrhosis, hepatocarcinoma) but without hepatitis B virus. This was more clearly seen in the patients with hepatitis. Although estrogen receptor expression was moderate to high in many samples, the expression of the two biochemical markers of estrogen action at postreceptor levels (progesterone receptor and hsp27) was low or absent in most of the liver tissues examined, suggesting that in the liver the interaction of estrogen–estrogen receptor–DNA has characteristics inherent to this tissue. (HEPATOLOGY 1991;13:838–844.)
Foreign Body in Air and Food Passages Roentgenologically Considered
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Periocular rash
Authors: Christina George, Sarah Walsh
Journal: BMJ (2018)

### What you need to know Skin problems around the eyes can be challenging to diagnose because the differential is wide. They can also be difficult to manage because the periorbital skin is sensitive, and there are a multitude of treatment options, with little specific guidance on their use. This practice pointer outlines the common causes of a periocular rash in an adult, and offers an approach to help diagnosis and management. Start by taking a focused history of the rash, including the time course and symptoms. A diagnostic approach and key clinical features of each diagnosis are summarised in the infographic. Consider examining the whole skin surface, not just the periocular site—often the distribution of the rash on the face and other body sites is key to making an accurate diagnosis.1 Box 1 provides further pointers to consider when examining the patient. Factors in the history and examination can help differentiate which type of pathology is the predominant problem. For example, inflammation (endogenous such as atopic eczema, or exogenous such as irritant dermatitis), oedema, dyspigmentation, and systemic diseases can all cause periocular rashes. Box 1 ### Clinical examination of periocular rash—key features #### MorphologyRETURN TO TEXT
The importance of empathy as an interviewing skill in medicine
Authors: P. S. Bellet
Journal: JAMA (1991)

IN HIS RESEARCH on the physician-patient relationship, Cousins<sup>1</sup>found that 85% of people had changed physicians or were thinking of changing in the past 5 years. Many of those who changed did so because of their physician's poor communication skills. One of the qualities of effective communication is the use of empathy. Because some physicians have not learned to use empathy in their training as medical students and residents, they may be ineffective in the care of patients.<sup>2</sup>In this article, we discuss the importance of empathy in medical practice and illustrate its use with two examples. <h3>What Is Empathy?</h3> Empathy is the capacity to understand what another person is experiencing from within the other person's frame of reference, ie, the capacity to place oneself in another's shoes.<sup>3</sup>The essence of empathic interaction is accurate understanding of another person's feelings. According to Aring,<sup>4</sup>it is hardly
A LEGAL OPINION OF THE MEDICAL PROFESSION.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Subject Index
Journal: Circulation Research (1965)

Acetylcholine, myocardial contractility and myocardial blood flow, 527 Acetylstrophanthidin infundibular pressure gradients and, 162 myocardial oxygen usage and coronary vascular resistance, 203 Action potentials, excitation propagation, 423 Adenosine triphosphatase, activity of cardiac myosin, 74 Adrenal glands, lipid histology and zona glomerulosa in rats with myocardial necrosis, 322 Adrenal steroids, aldosterone production by arteriosclerotic rats with myocardial necrosis, 322 Adrenergic amines, regional distribution in the heart, 39 Aldosterone, production during myocardial necrosis, 322 Alloxan, pulmonary edema and measurement methods, 482 Altitude, high, glomerular and pulmonary blood vessel changes in children, 33 Alveolar membrane, permeability coefficients for Na 24
Anticoagulation therapy in selected cancer patients at risk of recurrence of venous thromboembolism.
Authors: Annie Young, Jenny Phillips, Helen Hancocks, Andrea Marshall, Joanne Grumett, Janet Dunn, Oliver Chapman
Journal: Journal of Clinical Oncology (2015)

TPS9642 Background: Venous thromboembolism (VTE) in cancer patients is an important and increasingly frequent clinical problem. The impact of VTE on cancer patients can be considerable. Targeted patient selection by identifying patients with clinically relevant recurrent VTE may have wider health economic benefits whilst reducing patient risk through over-treatment. In the UK, dalteparin is the licensed anticoagulant for the extended treatment and prevention of recurrence of VTE in cancer patients and thus, the gold standard. Rivaroxaban is a highly selective direct Factor Xa inhibitor with oral bioavailability. Methods: Select-d is a prospective, randomised, open label, multicentre pilot trial comparing dalteparin (200 IU/kg daily subcutaneously for 1 month and 150 IU/kg months 2-6); and rivaroxaban (15 mg orally twice daily for 3 weeks and 20mg once daily for 6 months in total) for cancer patients with VTE, with a second placebo-controlled randomisation (rivaroxaban vs placebo) comparing the duration of therapy (6 vs 12 months) in residual vein thrombosis (RVT) positive patients. 70% of patients are estimated to be RVT positive after initial treatment. 530 patients are being recruited toprovide reliable estimates of the primary outcome (VTE recurrence rates) to within the 95% confidence interval of 8% assuming VTE rates are 10% at six months. The secondary objectives include safety, acceptability, biomarker identification and health economics. The select-d trial is amongst the first randomised trials of the new oral anticoagulants in patients with cancer, following recommendations from the UK National Institute of Health and Care Excellence. The select-d trial will recruit for two years with a minimum of one year follow up. The results will support optimal treatment for this key patient group. The independent TSC and DSMC fully support this important trial. Clinical trial information: ISRCTN86712308.
WRITER'S CRAMP AND ALLIED AFFECTIONS
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
USE OF ISOTOPES IN STUDIES OF HEMOGLOBIN FORMATION
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Scope, specifics of maternal drug use, effects on fetus are beginning to emerge from studies
Authors: S. Silverman
Journal: JAMA (1989)

LIMITED DATA are available on the number of women in the United States who use drugs during pregnancy or on the number of babies born with drugassociated defects. Studies conducted so far have been small and there has not been much uniformity of approach, according to Edgar Adams, PhD, National Institute on Drug Abuse (NIDA), Rockville, Md. <h3>15% Substance Abuse?</h3> The NIDA researchers estimate that of 56 million American women between 15 and 44 years of age, 15% (or about 8 million) are currently substance abusers. These findings, organized for a New York Academy of Sciences conference (<i>NY Academy Sci</i>. 1988;3:1,10-11), are based on data extracted from the 1985 National Household Survey on Drug Abuse, conducted by the NIDA on 8038 households (DHHS publication no.[ADM]88-1586). Drug use appears from the agency's data to be increasing. Of women aged 18 years and over, some 5 640 000 used marijuana in 1985—an
Factors influencing 3D-MRI diagnosis in preoperative breast cancer patients
Authors: K. Hisamatsu, W. Takiyama, R. Sakabe, Y. Satou, S. Saiki, H. Mukaida, Y. Yamashita, N. Hirabayashi, M. Kaneko, T. Ono
Journal: Journal of Clinical Oncology (2008)

607 Background: In breast cancer patients, accurate diagnosis of extent of disease is of great concern for deciding surgical procedure. The purpose of this study was to review imaging diagnosis using 3D-MRI and to evaluate accuracy of 3D-MRI diagnosis and factors influencing 3D-MRI diagnosis retrospectively. Methods: From July 2000, preoperative 3D-MRI was underwent 433 cases of breast cancer patients. Images were obtained from 426 cases (98%). These patients could be divided into four groups according to 3D-MRI images: pattern 1) localized type (243 cases), 2) widely enhanced type A (enhanced area: less than Quadrant [70 cases]) and 3) widely enhanced type B (enhanced area: more than Quadrant [24 cases]) and 4) multi-focal type (89 cases). Diagnosis of intraductal spread was confirmed by pathology and tumor size difference between 3D-MRI and specimens were assessed retrospectively. Results: The rate of histological confirmed intraductal spread was seen in 59% (143/243 cases), 84% (59/70 cases) and 83% (20/24 cases) of patients with 3D-MRI pattern 1), 2), and 3), respectively. From April 2005, the entire specimen was serially step cut and evaluated. Tumor diameter from nipple side to lateral margin was measured by MRI and specimens, tumor size was correlated between MRI and specimens, significantly (n=118, r=07186, p< 0.001). On multivariate analysis, factors influencing accuracy of tumor size in 3D-MRI (less than 1-cm difference) were histological confirmed intraductal spread in specimen (HR=30.64, p<0.001) and preoperative chemotherapy (HR=14.08, p<0.001). Selection for breast-conserving surgery and margin width were based on 3D-MRI images. The proportion of breast-conserving surgery was obtained 95% (231/243 cases), 90% (63/70 cases), 25% (6/24 cases) and 90% (80/89 cases) of patients with 3D-MRI pattern 1), 2), 3), and 4), respectively. Local failures were seen in 2 cases in pattern 1), one case in 3) and one case in 4) (2–90 months, median follow-up of 47 months). Conclusions: These results suggest that MRI will be the useful breast imaging tool in diagnosing intraductal spread and tumor size in breast cancer patients. However, careful management will be needed to do breast-conserving surgery in cases with preoperative systemic therapy and cases expected intraductal spread by other imaging tools. No significant financial relationships to disclose.
Infertility Clinic
Authors: Joan I. Siegel
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dirtball
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
12 Vasculitis
Authors: A BAKKALOGLU, S OZEN, E BASKIN, N BESBAS, O KASAPÇOPUR, A DUZOVA, F OZALTIN
Journal: Annals of the Rheumatic Diseases (2000)

Child Health Assessment Questionnaire), ESR).The results obtained in 8 children (4 systemic, 4 non-systemic) who were treated for more than 3 months are available.Mean (SD) age at disease onset was 6.6 (3) years, mean age at treatment was 13 (2.9)years.Four patients (3 non-systemic and one systemic) improved, four patients did not improved (3 systemic and one non-systemic).In conclusion, these preliminary results tend to show that patients with systemic onset JIA respond less to etanercept than patients with non-systemic onset JIA.
Manuscripts Approved for JNCI, July 1 to August 1, 1966
Journal: JNCI Journal of the National Cancer Institute (1966)

Journal Article Manuscripts Approved for JNCI, July 1 to August 1, 1966 Get access JNCI: Journal of the National Cancer Institute, Volume 37, Issue 3, September 1966, Page 399, https://doi.org/10.1093/jnci/37.3.399 Published: 01 September 1966
SIGNIFICANCE OF CERTAIN ANILINE STAINS FOR THE BIOCHEMISTRY OF THE CELLS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Putrid Gums and ‘Dead Men's Cloaths’: James Lind aboard the Salisbury
Authors: Graham Sutton
Journal: Journal of the Royal Society of Medicine (2003)

18th century sailors often suffered from scurvy. In 1747 James Lind conducted his classic experiments aboard the Salisbury, in which he cured scurvy with oranges and lemons. The Royal Navy did not introduce citrus rations until 1795. The original ship's papers allow the circumstances of the experiment to be reconstructed. The relevant patrol began in March 1747, and Lind's experiment began after 8 weeks at sea. The muster roll records almost no sickness aboard until the ship returned to Plymouth in June. This is at odds with Lind's account and suggests an anti-sickness official culture, which may have contributed to the neglect of his work.
Massachusetts Department of Public Health
Authors: Kenneth I. E. Macleod
Journal: New England Journal of Medicine (1952)

TYPHOID EPIDEMIOLOGYPainstaking follow-up of clues in epidemiologic studies of typhoid fever is often rewarded by the successful elucidation of the source of a case or an outbreak, but when the pointers are few, as occurred recently in the Worcester area, disappointments are often just as frequent.Two cases of typhoid fever, occurring within the same month in adjacent towns, proved to be due to the same phage type of organism and were probably connected. Thorough history taking and follow-up of clues led the investigator to a large food store. Through the co-operation of the management, a questionnaire and a . . .
Anticytokine strategies in the treatment of the systemic inflammatory response syndrome
Authors: C. A. Dinarello
Journal: JAMA (1993)

The systemic inflammatory response syndrome (SIRS) is an acute illness characterized by generalized activation of the endothelium. The most severe form of the syndrome is found in patients with shock due to gram-negative sepsis. We examined both animal and limited human data for the contribution of cytokines to this syndrome. Cytokines are endogenously produced proteins of small molecular weight and multiple biological effects. The cytokines interleukin 1 (IL-1) and tumor necrosis factor (TNF), as well as interferon-γ and interleukin 8, are discussed. Laboratory investigations suggest that these cytokines play a critical role in SIRS by promoting the biochemical and clinical characteristics of SIRS. The biochemical changes induced by TNF and IL-1 include increased synthesis of nitric oxide, prostaglandins, platelet-activating factor, and endothelial cell adhesion molecules. Specific blockade of TNF using neutralizing antibodies or soluble receptors to TNF in animal models of SIRS reduces mortality and severity of disease. Similar results have been observed blocking IL-1 using soluble IL-1 receptors or IL-1 receptor antagonists. Preliminary clinical studies suggest that blockade may be useful in treating human SIRS. The various strategies for blocking IL-1 and TNF are presented; in addition, their mechanism(s) of action and safety in humans are discussed. We conclude that based on animal studies and preliminary clinical trials, strategies to block IL-1 or TNF may benefit patients with the syndrome, although thorough clinical trials have not been completed. (<i>JAMA</i>. 1993;269:1829-1835)