tbuckley/cabot-search huggingface dataset:
Highlights from Recent Cancer Literature
Journal: Cancer Research (2019)

Tracking Melanoma Development in ZebrafishDespite significant improvements in the management of melanoma treatment, resistant disease remains a major clinical problem.MITF-low is a transcriptional subtype of melanoma with poor survival.Using a new inducible zebrafish model that mimics the human MITF-low subtype, Travnickova and colleagues showed that a MITF-low state is causal for melanoma development and that MITF is a lineagedependent oncogene.They then tracked cells during melanoma regression and identified a small population of cells at the regression site that were resistant to complete MITF loss.These MITFindependent cells share similar molecular expression signatures with human therapy-resistant disease.Expert Commentary: The identification of a MITF-independent cell state in residual disease that preexists in primary melanoma may explain the poor outcomes in patients with MITF-low melanomas and could represent an important new target.(Image from cited article courtesy of the publisher.
Highlights of This Issue
Journal: Clinical Cancer Research (2019)

177 Lu-Satoreotide Tetraxetan in Well-Differentiated NETs Peptide receptor targeted radionuclide therapy (PRRT) with the somatostatin receptor (sstr) agonist 177 Lu-DOTA-TATE has recently been approved for treatment of advanced neuroendocrine tumors (NETs).Preclinical studies have suggested improved targeting of NETs with radiolabeled sstr antagonists.This phase I clinical trial of the sstr antagonist177
Acknowledgement to Referees
Authors: Vandana Abramson, Robert Adler, Timothy Albertson, Martin Almquist, Hanny Sweden, Sabina Antoniu, Romania Arribas, Elizabeth Ashley, Jutta Auberger, Idelberto Germany, Jared Badell, Osnat Baeten, Israel Bairey, Simona Baldassari, Aleksandra Barac, Robert Barkin, Fabio Barroso, Argentina Bassetti, Anastas Batalov, Charles Bulgaria, Al Bennett, Daniela Benson, Michael Berg, Laura Bonanno, Anthony Bonavia, Laura Bonnett, Joseph Bonventre, Niels Boone, The Netherlands, Claudio Borghi, Helen Boucher, Charlotte Boughton, Michel Burnier, Joseph Switzerland, Andrea Calabrese, Zyad Carr
Journal: Drugs (2019)
Highlights from Recent Cancer Literature
Journal: Cancer Research (2019)

Imaging PEG10 Expression in Prostate CancerPaternally expressed gene 10 (PEG10) primarily expressed in the placenta is crucial for embryonic development.PEG10 isoforms promote the progression of prostate cancer to a highly lethal androgen receptor (AR)-negative phenotype.Shapovalova and colleagues found that PEG10 expression was not restricted to AR-null disease but was also expressed in prostate cancer with constitutively active AR-splice variants.Using the cancer specificity of the PEG10 promoter, the authors created a molecular genetic imaging tool to detect these highly lethal prostate cancer subtypes.The imaging strategy incorporated an optimized PEG10 promoter and a two-step transcriptional amplification element for enhanced output.The final imaging construct allowed precise tumor detection in PEG10-positive castration-resistant prostate cancer animal models by near infrared and PET/CT imaging.Expert Commentary: Preclinical proof of concept is provided, indicating that the PEG10 promoter is a potent and specific tool that can be utilized for noninvasive detection of aggressive prostate cancer subtypes.(Image from cited article courtesy of the publisher.)
Highlights from Recent Cancer Literature
Journal: Cancer Research (2019)

The responsible alterations in hereditary pancreatic ductal carcinoma (PDAC) are unknown in most cases.Nissim and colleagues utilized a whole-genome sequence analysis in a family with high prevalence of PDAC and found that germline RABL3 mutations were associated with hereditary PDACs and RASopathy syndromes.These novel germline RABL3 mutations increased proliferation in vitro and accelerated tumorigenesis in zebrafish cancer models.Mutant RABL3 increased KRAS activity through binding to RAP1GDS1, resulting in increased KRAS prenylation.RABL3 was also overexpressed in sporadic PDAC and was required for proliferation.Expert Commentary: This study not only identified novel germline RABL3 mutations, which predispose to hereditary PDAC, but also uncovered a potentially novel target in PDAC.
Highlights from Recent Cancer Literature
Journal: Cancer Research (2019)

p53-Deficiency Drives Neutrophilic Inflammation and MetastasisSystemic neutrophilic inflammation is an established driver of metastasis, however, the tumor cellintrinsic factors that are responsible for this are poorly understood.Wellenstein and colleagues utilized a genetically diverse collection of breast cancer mouse models to elucidate whether distinct genetic subtypes influenced the levels of systemic neutrophilic inflammation.They found that p53deficiency was associated with increased systemic and tumor neutrophilia and metastasis.This was a p53-dependent process mediated through secretion of WNT ligands, leading to IL1b production in tumor-associated macrophages (TAM).Inhibition of WNT ligand secretion decreased IL1b production in TAMs and tumor metastases.Expert Commentary: This study suggests that inhibition of WNT secretion may be an effective therapeutic strategy in p53-deficient breast cancer to prevent metastases.
Endoscopy International Open – recently published
Journal: Endoscopy (2019)

Comment on:Delayed hemorrhage after cold and hot snare resection of colorectal polyps: a multicenter randomized trial (interim analysis)Endosc Int Open 2019; 07(09): E1123-E1129DOI: 10.1055/a-0854-3561Comment on:Endoscopic transpapillary gallbladder stenting using a newly designed plastic stent for acute cholecystitisEndosc Int Open 2019; 07(09): E1105-E1114DOI: 10.1055/a-0747-5668Comment on:EUS-guided gallbladder drainage in patients with cirrhosis: results of a multicenter retrospective studyEndosc Int Open 2019; 07(09): E1099-E1104DOI: 10.1055/a-0965-6662
Highlights from Recent Cancer Literature
Journal: Cancer Research (2019)

Single-Cell View of Medulloblastoma SubgroupsTo discern intratumoral heterogeneity, Hovestadt and colleagues performed single-cell RNA (scRNA)sequencing on 25 primary medulloblastomas and 9 patient-derived xenografts.WNT, SHH, and Group 3 tumors comprised a mix of undifferentiated and differentiated malignant neural programs, while Group 4 tumors showed differentiated neural neoplastic programs.Common genetic driver events were present across all cells, suggesting relative homogeneity within driver events.The immune cell contribution was minimal.The majority of medulloblastomas were comprised of malignant cells.SHH tumors were most closely related to the external granular layer.Group 4 closely resembled glutaminergic LMX1A-expressing unipolar brush cells.WNT and Group 3 did not match to any cerebellar time point, suggestive of an extracellular origin.Expert Commentary: The identification of a candidate cell of origin for Group 4, the most common subgroup of medulloblastoma, has profound implications for future preclinical modeling.Multiple malignant programs within each subgroup provide further insight into the intratumoral heterogeneity within medulloblastoma subgroups.
Highlights from Recent Cancer Literature
Journal: Cancer Research (2019)

EN1 and Breast Cancer Brain MetastasisTriple-negative breast cancer (TNBC) constitutes 10%-20% of breast cancers in the U.S. and has a high risk of developing distant metastases.Peluffo and colleagues used a targeted cellular viability screen to identify transcription factors displaying high expression in TNBCs.EN1 (engrailed 1), a transcription factor with known roles in brain and dermomyotome development, was overexpressed in TNBCs, and its downregulation preferentially and significantly reduced viability and tumorigenicity in TNBC cell lines.Additionally, high expression of EN1 correlated with short overall survival and increased risk of developing brain metastases in TNBC patients.Expert Commentary: This study identifies EN1 as a TNBC-specific transcription factor whose expression is associated with neural features, angiogenesis, and brain metastasis of breast cancers, leading to poor outcome.Targeting of EN1 and neuroligins might be explored as a potential therapeutic strategy for the prevention and treatment of brain metastases caused by TNBCs.(Image from cited article courtesy of the publisher).
Editorial Board and Contents
Authors: Axel Rossberg, György Barabás, Hugh Possingham, Mercedes Pascual, Pablo Marquet, Cang Hui, Matthew Evans, Géza Meszéna, Weihua Xu, Stuart Pimm, Ao Du, Yang Su, Xinyue Fan, Li An, Jianguo Liu, Zhiyun Ouyang, Philip Thomsen, Benjamin Parrott, Emily Bertucci, P O', B Lyver, P Timoti, T Davis, J Tylianakis, Timothy Bonebrake, Fengyi Guo, Caroline Dingle, David Baker, Roger Kitching, Louise Ashton, Fabrice Requier, Lionel Garnery, Patrick Kohl, Henry Njovu, Christian Pirk, Robin Crewe, Ingolf Steffan-Dewenter, Raúl González-Pech, Debashish Bhattacharya, Mark Ragan, Cheong Chan, Andrea Stephens, Jessica Miles, Margriet Ten Napel, Patrick Scheffmann, Göran Arnqvist, Spencer Barrett, Ragan Callaway, Stephen Carpenter, James Clark, Paul Craze, Rodolfo Dirzo, Andrew Dobson, Michael Donoghue, Douglas Erwin, Stephen Jackson, Christian Körner, Robert Lanfear, William Laurance, Georgina Mace, Harold Mooney, Randolph Nesse, Samir Okasha, Sarah Otto, Linda Partridge, Andrew Read, Rebecca Safran, Christine Simon, William Sutherland, Boris Worm
Journal: Trends in Ecology & Evolution (2019)
Editorial Board and Contents
Authors: Aaron Batista, Konrad Kording, Katherine Tonn Eisinger, Anne West, Julie Savage, Marie-Ève Tremblay, Anastasia Kiyonaga, Jason Scimeca, Michaela Filiou, Carmen Sandi, Cyriel Pennartz, Shirin Dora, Lars Muckli, Jeannette Lorteije, Christos Constantinidis, Beatriz Luna, Baljit Khakh, Tamar Farfel-Becker, Jenny Do, Nahid Tayebi, Ellen Sidransky, Ruslan Rust, Lisa Grönnert, Rebecca Weber, Geertje Mulders, Martin Schwab, Moran Furman, Jessica Miles, Fred Kop, Patrick Scheffmann, Silvia Arber, Anders Björklund, J Paul Bolam, Sarah Bottjer, Rui Costa, Ann Marie, Craig Barry, J Dickson, Chris Doe, Craig Garner, Yukiko Goda, Kenneth Harris, Nancy Ip, Meyer Jackson, Maria Karayiorgou, Robert Malenka, Mark Mattson, Freda Miller, Richard Morris, Maiken Nedergaard, Eric Nestler, Anna Roe, Hitoshi Sakano, Greg Stuart, Marc Tessier-Lavigne, Chris Walsh
Journal: Trends in Neurosciences (2019)
Highlights from Recent Cancer Literature
Journal: Cancer Research (2019)

Tissue-Specific Acquisition of Mutations Over TimeThere is a poor understanding of how somatic mutations accumulate over the course of a person's lifetime.To shed light on this, Yizhak and colleagues used RNA sequencing data from more than 6,700 samples from around 500 individuals, spanning across 29 different normal tissues.They found that mutations existed in several normal tissues.Interestingly, the authors observed that sun-exposed skin, esophagus, and lung had a higher mutation burden than other tissues analyzed, suggesting that environmental exposure can promote somatic mosaicism.Age-and tissue-specific proliferation rates were associated with mutation burden, showing that mutations accumulate over both time and number of cell divisions.In addition, normal tissues were found to harbor mutations in known cancer genes and hotspots.Expert Commentary: By revealing mutational burden in different normal human tissues, this study provides an advance in our understanding of early cancer development.
Editorial Board and Contents
Authors: Kusumika Mukherjee, Jessica Miles, Fred Kop, Patrick Scheffmann, Michelle Arkin, Jacqueline Crawley, A Cuello, Laszlo Hunyady, Magnus Ingelman-Sundberg, Allan Kalueff, Terry Kenakin, Brian Kobilka, Michel Lazdunski, Christian Lüscher, Fiona Marshall, Jacopo Meldolesi, Wouter Moolenaar, Ruth Nussinov, Clive Page, Leonardo Pardo, Harald Sitte, Roger Summers, Rachel Tyndale, Ming-Wei Wang, Stephen Watson, Stephen Waxman
Journal: Trends in Pharmacological Sciences (2019)
A breakthrough trial of an artificial liver without systemic heparinization in hyperbilirubinemia beagle models
Authors: Yilin Wang, Shanshan Wang, Xueqin He, Yupei Li, Tao Xu, Lin Xu, Bo Yang, Xinnian Fan, Weifeng Zhao, Changsheng Zhao
Journal: Bioactive Materials (2022)

The development of wearable artificial livers was restricted to device miniaturization and bleeding risk with water-soluble anticoagulants. Herein, a double-deck column filled with solid anticoagulant microspheres and Kevlar porous microspheres (KPMs, bilirubin adsorbents) was connected with the principle machine of wearable artificial liver (approximately 9 kg) to treat hyperbilirubinemia beagles for the first time. With the initial normal dose of heparin, the double-deck column could afford 3 h hemoperfusion in whole blood without thrombus formation. The removal efficiency of the double-deck column for total bilirubin (TBIL) was 31.4%. Interestingly, the excessive amounts of hepatocyte metabolites were also decreased by approximately 25%. The "anticoagulant + column" realized safe and effective whole blood hemoperfusion without the plasma separation system and heparin pump; however, the proposed principle machine of wearable artificial liver and "anticoagulant + column" cannot completely replace the bio-liver now. The intelligence of the device and the versatility of the adsorbent need to be improved; moreover, advanced experimental techniques need to be developed to validate the survival rates in animals. Overall, this study is a meaningful trial for the development of wearable artificial livers in the future.
3D-printed auxetic-structured intervertebral disc implant for potential treatment of lumbar herniated disc
Authors: Yulin Jiang, Kun Shi, Luonan Zhou, Miaomiao He, Ce Zhu, Jingcheng Wang, Jianhua Li, Yubao Li, Limin Liu, Dan Sun, Ganjun Feng, Yong Yi, Li Zhang
Journal: Bioactive Materials (2022)

In this study, a novel artificial intervertebral disc implant with modified "Bucklicrystal" structure was designed and 3D printed using thermoplastic polyurethane. The new implant has a unique auxetic structure with building blocks joined "face-to-face". The accompanied negative Poisson's ratio enables its excellent energy absorption and stability under compression. The deformation and load distribution behavior of the implant under various loading conditions (bending, torsion, extension and flexion) has been thoroughly evaluated through finite element method. Results show that, compared to natural intervertebral disc and conventional 3D implant, our new implant exhibits more effective stress transfer and attenuation under practical loading conditions. The implant's ability to contract laterally under compression can be potentially used to alleviate the symptoms of lumbar disc herniation. Finally, the biocompatibility of the implant was assessed in vitro and its ability to restore the physiological function of the disc segment was validated in vivo using an animal model.
Bioinspired poly(cation-π) micelles drug delivery platform for improving chemotherapy efficacy
Authors: Guozhu Tan, Yu Wang, Yuejian He, Guifeng Miao, Yang Li, Xiaorui Wang
Journal: Journal of Controlled Release (2022)

Cation-π interactions widely exist in biological systems and play important roles in driving the self-assembly of biological molecules, stabilizing protein structures, and mediating molecular recognitions. Herein, a novel bioinspired poly(cation-π) micelles drug delivery platform is designed and constructed, based on the block copolymers with random cationic-aromatic sequences (amphiphilic cation-π polymer). Compared to the polymeric micelles formed by conventional amphiphilic block copolymers which are commonly limited to hydrophobic drugs loading, the engineered poly(cation-π) micelles can serve as a universal nanocarrier for a wide variety of hydrophobic and hydrophilic drugs with π-structure. It is found that due to the strong cation-π interactions integrated in the core of poly(cation-π) micelles, this nanosystem performs improved structural stability and higher drug loading capability. Especially, in the oxidation-responsive poly(cation-π) micelles as proof-of-concept, the process of stimuli-induced drug release is found significantly accelerated under the biologically relevant level of H2O2 in tumor microenvironment. Furthermore, the mechanism of cation-π interaction enhanced H2O2-sensitivity of poly(cation-π) micelles is proposed, and the improving anti-tumor efficacy is demonstrated in both in vitro and in vivo models. This work broadens the construction strategy of polymeric micelles and offers a universal drug delivery platform for efficient tumor chemotherapy.
As Unexplained Hepatitis Spreads, WHO Urges Action
Authors: Howard D. Larkin
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiometabolic outcomes up to 12 months after COVID-19 infection. A matched cohort study in the UK
Authors: Emma Rezel-Potts, Abdel Douiri, Xiaohui Sun, Phillip J. Chowienczyk, Ajay M. Shah, Martin C. Gulliford
Journal: PLoS Medicine (2022)

Acute Coronavirus Disease 2019 (COVID-19) has been associated with new-onset cardiovascular disease (CVD) and diabetes mellitus (DM), but it is not known whether COVID-19 has long-term impacts on cardiometabolic outcomes. This study aimed to determine whether the incidence of new DM and CVDs are increased over 12 months after COVID-19 compared with matched controls. We conducted a cohort study from 2020 to 2021 analysing electronic records for 1,356 United Kingdom family practices with a population of 13.4 million. Participants were 428,650 COVID-19 patients without DM or CVD who were individually matched with 428,650 control patients on age, sex, and family practice and followed up to January 2022. Outcomes were incidence of DM and CVD. A difference-in-difference analysis estimated the net effect of COVID-19 allowing for baseline differences, age, ethnicity, smoking, body mass index (BMI), systolic blood pressure, Charlson score, index month, and matched set. Follow-up time was divided into 4 weeks from index date ("acute COVID-19"), 5 to 12 weeks from index date ("post-acute COVID-19"), and 13 to 52 weeks from index date ("long COVID-19"). Net incidence of DM increased in the first 4 weeks after COVID-19 (adjusted rate ratio, RR 1.81, 95% confidence interval (CI) 1.51 to 2.19) and remained elevated from 5 to 12 weeks (RR 1.27, 1.11 to 1.46) but not from 13 to 52 weeks overall (1.07, 0.99 to 1.16). Acute COVID-19 was associated with net increased CVD incidence (5.82, 4.82 to 7.03) including pulmonary embolism (RR 11.51, 7.07 to 18.73), atrial arrythmias (6.44, 4.17 to 9.96), and venous thromboses (5.43, 3.27 to 9.01). CVD incidence declined from 5 to 12 weeks (RR 1.49, 1.28 to 1.73) and showed a net decrease from 13 to 52 weeks (0.80, 0.73 to 0.88). The analyses were based on health records data and participants' exposure and outcome status might have been misclassified. In this study, we found that CVD was increased early after COVID-19 mainly from pulmonary embolism, atrial arrhythmias, and venous thromboses. DM incidence remained elevated for at least 12 weeks following COVID-19 before declining. People without preexisting CVD or DM who suffer from COVID-19 do not appear to have a long-term increase in incidence of these conditions.
Albumin vs Crystalloid Fluid for Resuscitation in Cardiac Surgery
Authors: Mihai V. Podgoreanu, Negmeldeen Mamoun
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Establishing Optimal Gestational Weight Gain in Twin Pregnancies With a Prerequisite Rationale—A Tour de Force
Authors: Pierre-Yves Robillard
Journal: JAMA Network Open (2022)

Dongxin Lin, MD; Xuqiong Huang, MD; Dazhi Fan, MD; Gengdong Chen, PhD; Pengsheng Li, PhD; Jiaming Rao, MD; Huishan Zhang, MD; Xiaoling Guo, BD; Caihong Luo, BD; Zhengping Liu, MD
Metastatic Risk Stratification of 2526 Medullary Thyroid Carcinoma Patients: A Study Based on Surveillance, Epidemiology, and End Results Database
Authors: Minh-Khang Le, Masataka Kawai, Toru Odate, Huy Gia Vuong, Naoki Oishi, Tetsuo Kondo
Journal: Endocrine Pathology (2022)
COVID-19 Vaccination Perspectives and Illnesses Among Law Enforcement Officers, Firefighters, and Other First Responders in the US, January to September 2021
Authors: Alberto J. Caban-Martinez, Manjusha Gaglani, Lauren E. W. Olsho, Lauren Grant, Natasha Schaefer-Solle, Mark G. Thompson, Jefferey L. Burgess
Journal: JAMA Network Open (2022)

Among 1415 participants, 1113 (79%
Postoperative Day One
Authors: Ivana Viani
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal