tbuckley/cabot-search huggingface dataset:
Venetoclax Treatment Outcomes and Patterns of Use in Relapsed/Refractory Chronic Lymphocytic Leukemia Under Routine Clinical Practice in Saudi Arabia and Gulf Countries (VICTORY Study)
Authors: Tarek Abouzeid, Taimoor Hussain, Sameer AlAmoudi, Ahmad Absi, Arif Alam, Mansour Alfayez, Ahmad Alhuraiji, Mohammed Aldarweesh, Husni Al-Hateeti, Gehad El Ashal, Omar Hussein, Ali Anwar, Mohamed Gouda Ismail, Leila Bereksi, Haidy Abdellatif, Yasser Nour, Abdallah Saad, Naeem A. Chaudhri
Journal: Blood (2022)
Predictors of Hematologic Complete Response Achievement and Maintenance in Patients with AL Amyloidosis Treated with Non-Transplant Chemotherapy
Authors: Paolo Milani, Claudia Bellofiore, Marco Basset, Andrea Foli, Pietro Benvenuti, Francesca Fabris, Martina Nanci, Mario Nuvolone, Giampaolo Merlini, Giovanni Palladini
Journal: Blood (2022)
Real World Efficacy and Toxicity of Selinexor: Importance of Dose Intensity and Post Progression Outcomes
Authors: Efstathios Kastritis, Panagiotis Malandrakis, Vasiliki Spiliopoulou, Ioannis Ntanasis-Stathopoulos, Eirini Solia, Foteini Theodorakakou, Rodanthi Syrigou, Nikoletta-Aikaterini Kokkali, Magdalini Migkou, Evangelos Eleutherakis Papaiakovou, Despina Fotiou, Maria Roussou, Nikolaos Kanellias, Maria Gavriatopoulou, Evangelos Terpos, Meletios A. Dimopoulos
Journal: Blood (2022)
LPA81: Discovery of an Exceptionally Potent Protac Degrading Native and Mutant BCR-ABL1 Oncoprotein in CML
Authors: Milad Rouhimoghadam, Hua Tang, Junzhuo Liao, Briana Bates, Daniela Uribe-Cano, Helong Zhao, Weiping Tang, Michael W. Deininger
Journal: Blood (2022)
Determining Hemodilution in Diagnostic Bone Marrow Samples in Multiple Myeloma and Its Precursors By Next-Generation Flow Cytometry: Data from the Iceland Screens, Treats, or Prevents Multiple Myeloma (iStopMM) Study
Authors: Jón Þórir Óskarsson, Sæmundur Rögnvaldsson, Sigrún Thorsteinsdóttir, Hrafnhildur Una þórðardóttir, Gudlaug Katrin Hakonardottir, Steinar Bragi Gunnarsson, Gudrún Ásta Sigurdardóttir, Ásdis Rósa Thórdardottir, Gauti Gíslason, Andri Olafsson, Jon Kristinn Sigurdsson, Brynjar Vidarsson, Páll Torfi Onundarson, Bjarni Agnar Agnarsson, Robert Palmason, Margrét Sigurdardóttir, Ingunn Thorsteinsdóttir, Ísleifur Ólafsson, Juan Flores-Montero, Alberto Orfao, Brian G.M. Durie, Thorvardur Jon Love, Sigurdur Y Kristinsson
Journal: Blood (2022)
Phase 2 Randomized, Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of Plamotamab Combined with Tafasitamab (Tafa) + Lenalidomide (Len) Vs Tafa+Len in Relapsed or Refractory DLBCL
Authors: Krish Patel, Youngil Koh, Sabarish Ayyappan, Yasmin Karimi, Izidore S. Lossos, Akil Merchant, Phuong Lee, Jianhua Jin, Raphael Clynes, Jitendra Kanodia, Michael T. Chiarella, Steve Kye, Jean-Marie Michot
Journal: Blood (2022)
AML and MDS Classification According to Who 2022 and International Consensus Classification: Do We Invent a Babylonian Confusion of Languages?
Authors: Sandra Huber, Constance Baer, Stephan Hutter, Frank Dicker, Manja Meggendorfer, Christian Pohlkamp, Wolfgang Kern, Torsten Haferlach, Claudia Haferlach, Gregor Hoermann
Journal: Blood (2022)
Dedalo: Phase II Study of Daratumumab Plus Pomalidomide and Dexamethasone (DPd) in Patients with Relapsed/Refractory Multiple Myeloma and 17p Deletion
Authors: Vittorio Montefusco, Anna Maria Cafro, Gloria Margiotta Casaluci, Francesca Patriarca, Roberto Mina, Mattia D'Agostino, Andrea Capra, Claudia Priola, Anna Benedetta Dalla Palma, Rita Rizzi, Angelo Genua, Maria Teresa Petrucci, Laura Paris, Angelo Belotti, Michele Cavo, Concetta Conticello, Carmelo Carlo-Stella, Mario Boccadoro
Journal: Blood (2022)
Validating the Prognostic Value of Anemia and Thrombocytopenia in Latin American Patients with Diffuse Large B-Cell Lymphoma: A Study from the Grupo De Estudio Latinoamericano De Linfoproliferativos (GELL)
Authors: Luis Mario Villela Martinez, Brady E. Beltrán, Marialejandra Alejandra Torres Viera, Henry Idrobo, Myrna Candelaria, Guilherme Fleury Perini, Ana Carolina Oliver, Denisse Castro, Rosa Oliday, Sally Rose Paredes, Ana Florencia Ramirez-Ibarguen, Lidiane Andino, Silvia Rivas-Vera, Seisha Alana Von Glasenapp Gossen, Victoria Irigoin, Gladys P Agreda, Fernando Perez-Jacobo, Perla R.R. Colunga-Pedraza, Efreen Montaño Figueroa, Lorena Fiad, Fabiola Valvert, Camila Peña, Jose A Hernández-Hernández, Virginia Otero, Melani Otañez, Guillermo J. Ruiz-Arguelles, Arianna Robles, Carlos Best, David Gomez-Almaguer, Rosio Baena, Saul Urquijo, Eleazar Hernandez, Jose Luis Álvarez, Melissa Castro, Jorge J. Castillo, Luis Enrique Malpica Castillo
Journal: Blood (2022)
An End-of-Study Subgroup Analysis of Black Patients from the Phase 2 Griffin Study of Daratumumab (DARA) Plus Lenalidomide, Bortezomib, and Dexamethasone (RVd) in Patients with Transplant-Eligible Newly Diagnosed Multiple Myeloma (NDMM)
Authors: Ajay K. Nooka, Jonathan L. Kaufman, Cesar Rodriguez, Andrzej Jakubowiak, Yvonne A. Efebera, Brandi Reeves, Tanya M. Wildes, Sarah A. Holstein, Larry D. Anderson, Ashraf Z. Badros, Leyla O. Shune, Ajai Chari, Huiling Pei, Annelore Cortoos, Sharmila Patel, Thomas S. Lin, Paul G. Richardson, Saad Usmani, Peter M. Voorhees
Journal: Blood (2022)
Odronextamab in Patients with Relapsed/Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL): Results from a Prespecified Analysis of the Pivotal Phase II Study ELM-2
Authors: Won-Seog Kim, Tae Min Kim, Seok-Goo Cho, Isidro Jarque, Elżbieta Iskierka-Jażdżewska, Michelle Limei Poon, H. Miles Prince, Sung Yong Oh, Francesca Lim, Cecilia Carpio, Tran-Der Tan, Sabarish Ayyappan, Antonio Gutierrez, Jingjin Li, Melanie Ufkin, Min Zhu, Aafia Chaudhry, Hesham Mohamed, Srikanth R. Ambati, Jan Walewski
Journal: Blood (2022)
Functional and Molecular Characterisation of Prospectively Isolated Subclones in Individual AML Patients Reveals Distinct Gene Regulatory Networks Linked to Targetable Metabolic Vulnerabilities
Authors: Shanna M Hogeling, Roos Houtsma, Nisha K Van Der Meer, Salam A. Assi, Paulynn Chin, Alan Cunningham, Peter Keane, Dominique Sternadt Alexandre Ramos, Lieve Oudejans, Gerwin A. Huls, Constance Bonifer, Jan Jacob Schuringa
Journal: Blood (2022)
Characterization of the Immunophenotypical Profile By Flow Cytometry of Patients with Adult T-Cell Leukemia/Lymphoma
Authors: Giovani Arlindo Silva, Flavio Cristine Medeiros Theodoro, Taissa Moura Oliveira, Rafael Duarte Lima, Maria das Graças Pereira Araújo, Lenilton Silva Silveira, Victor lima Soares, Ciro Alexandre Mercês Gonçalves, Arthur Felipe Araujo Dantas, Gustavo Henrique de Medeiros Oliveira, Gustavo Henrique de Medeiros Oliveira, Dany Geraldo Kramer Cavalcanti Silva, Aldair Sousa Paiva, Hugo Diogenes De Oliveira Paiva, Catarina Silva de Souza Diogenes, Aline Abreu Diogenes, Maria Jacqueline Nogueira Souza, Geraldo Barroso Cavalcanti
Journal: Blood (2022)
Real-World Results of CAR-T Cell Therapy for Large B Cell Lymphoma with CNS Involvement: A GLA/DRST Study
Authors: Francis A. Ayuk, Nico Gagelmann, Gerald Wulf, Bastian von Tresckow, Kai Rejeski, Matthias Stelljes, Olaf Penack, Claudia D. Baldus, Nicolaus Kröger, Wolfgang Bethge, Peter Dreger
Journal: Blood (2022)
Secondary Analysis of the MM21 Trial: Response Adaptive Salvage Treatment with Daratumumab-Lenalidomide-Dexamethasone (DRd) for Newly Diagnosed Transplant Eligible Multiple Myeloma Patients Failing Front-Line Bortezomib-Based Induction Therapy
Authors: Sueh-li Lim, John Reynolds, Hang Quach, Anna Hutchinson, Ian H Kerridge, Jane Estell, Craig wallington-Gates, Anna Kalff, Flora Yuen, Andrew Spencer
Journal: Blood (2022)
Muscle and Fat Composition in Patients with Newly Diagnosed Multiple Myeloma
Authors: Nadine Abdallah, Hiroki Nagayama, Naoki Takahashi, Wilson I. Gonsalves, Amie Fonder, Angela Dispenzieri, David Dingli, Francis K. Buadi, Martha Q. Lacy, Miriam A. Hobbs, Morie A. Gertz, Moritz Binder, Prashant Kapoor, Rahma M Warsame, Suzanne R. Hayman, Taxiarchis Kourelis, Yi L. Hwa, Yi Lin, Robert A. Kyle, S. Vincent Rajkumar, Stephen Broski, Shaji K Kumar
Journal: Blood (2022)
An External Control for Mosunetuzumab Using Real-World Data in Follicular Lymphoma in the Third or Subsequent Lines of Systemic Therapy
Authors: Sarah F. McGough, Natasha Shamas, Jue Wang, Mahmoud Jaber, Binay Swarup, Marie-Helene Blanchet Zumofen, Bertrand Lautié, Joana Parreira, Michael C. Wei, Ashwini Shewade
Journal: Blood (2022)
Cord Derived 8F4CAR-iNKT Cells to Prevent Acute Myeloid Leukemia Relapse and Graft Vs. Host Disease after Allogeneic Stem Cell Transplantation
Authors: Maison Grefe, Abel Trujillo-Ocampo, Drew Boagni, Jelita Clinton, Hong He, Karen Clise-Dwyer, Hyunwoo Cho, Elizabeth J Shpall, Jeffrey J. Molldrem, Jin S. Im
Journal: Blood (2022)
Ponatinib and Blinatumomab for Patients with Relapsed/Refractory Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia or Chronic Myeloid Leukemia in Lymphoid Blast Phase: A Subgroup Analysis from a Phase II Study
Authors: Walid Macaron, Hagop Kantarjian, Nicholas Short, Nitin Jain, Xuelin Huang, Guillermo Montalban-Bravo, Tapan M. Kadia, Naval Daver, Kelly S. Chien, Yesid Alvarado, Guillermo Garcia-Manero, Ghayas C. Issa, Fadi Haddad, Monica Kwari, Ricardo Delumpa, Ejiroghene Mayor, Wuliamatu Deen, Jennifer Thankachan, Christopher Loiselle, Juan Rivera, Anna Milton, Lourdes Waller, Glenda Banks, Rebecca Garris, Marina Konopleva, Farhad Ravandi, Elias Jabbour
Journal: Blood (2022)
CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy for Adults with B-Cell Acute Lymphoblastic Leukemia (B-ALL): A Large Real-World Series from Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT)
Authors: Eolia Brissot, Christophe Peczynski, Myriam Labopin, Federico Lussana, Rachael Hough, Jurgen Kuball, Wolf Roesler, Sabine Furst, Pere Barba, Michael Daskalakis, Tayfun Gungor, Marc Bierings, Caroline Besley, Ioanna Sakellari, Dimitrios Karakasis, Mi Kwon, Nathalie Fegueux, Annalisa Ruggeri, Christian Chabannon, Sebastian Giebel, Zinaida Peric, Arnon Nagler, Fabio Ciceri, Mohamad Mohty
Journal: Blood (2022)
Efficacy, Safety, and Population Pharmacokinetic Modeling of Intravenous Recombinant <i>Erwinia</i> Asparaginase (JZP458) in Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma: Results from Study AALL1931
Authors: Luke Maese, Mignon L. Loh, Mi Rim Choi, Tong Lin, Etsuko Aoki, Shirali Agarwal, Xiaotian Wu, Robert Iannone, Jeffrey A. Silverman, Lewis B. Silverman, Elizabeth A. Raetz, Rachel E. Rau
Journal: Blood (2022)
Risk Factors Influencing Humoral Response to COVID 19 Vaccination after Allogeneic Stem Cell Transplantation
Authors: Marie Luise Hütter-Krönke, Adela Neagoie, Igor Wolfgang Blau, Lam Giang Vuong, Maral Saadati, Axel Benner, Lars Bullinger, Hartmut Döhner, Donald Bunjes, Elisa Sala
Journal: Blood (2022)
Rivaroxaban Versus Apixaban for Treatment of Cancer-Associated Venous Thromboembolism: A Head-to-Head Analysis of the United States Cohort of the Observational Study in Cancer-Associated Thrombosis for Rivaroxaban: (H2H-OSCAR-US)
Authors: Kimberly Snow Caroti, Khaled Abdelgawwad, George Psaroudakis, Marcela Rivera, Gunnar Brobert, Alexander T Cohen, Alok A Khorana, Cecilia Becattini, Agnes Y. Lee, Anders Ekbom, Marc Carrier, Craig I. Coleman
Journal: Blood (2022)
Phase Ib/II Trial of the Bruton's Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Combination with Rituximab and Lenalidomide in Refractory/Recurrent Primary (PCNSL) and Secondary Central Nervous System Lymphoma (SCNSL)
Authors: Christian Grommes, Anna Piotrowski, Elena Pentsova, Igor Gavrilovic, Jacqueline B Stone, Andrew Lin, Venissala Wongchai, Juli T Madzsar, Rachna Malani, Craig Nolan, Jasmine Francis, Lisa DeAngelis, Lauren Schaff, Ingo K Mellinghoff
Journal: Blood (2022)
The Efficacy of High-Dose Versus Intrathecal Methotrexate for Diffuse Large B-Cell Lymphoma with High Risk of CNS Relapse: A Multicenter Retrospective Study with Uniform CNS Prophylaxis
Authors: Masahiro Akimoto, Takuya Miyazaki, Hiroyuki Takahashi, Yusuke Saigusa, Takaaki Takeda, Yuto Hibino, Mayumi Tokunaga, Takuma Ohashi, Ayako Matsumura, Haruka Teshigawara, Taisei Suzuki, Hiroshi Teranaka, Yuki Nakajima, Kenji Matsumoto, Chizuko Hashimoto, Katsumichi Fujimaki, Hiroyuki Fujita, Rika Sakai, Shin Fujisawa, Hideaki Nakajima
Journal: Blood (2022)
Impact of Transfusions and Treatment Choice on Time Spent in Healthcare Facilities for Patients with Myelodysplastic Syndromes
Authors: Mikkael A. Sekeres, Guillermo Garcia-Manero, David L. Grinblatt, Rami S. Komrokji, Michael R. Savona, Harry P. Erba, Gail J. Roboz, Irene S. DeGutis, Pavel Kiselev, Edward Yu, Adeola Y. Makinde, Ali McBride, Bart L. Scott
Journal: Blood (2022)
Biological Characterization and Differential Gene Expression Analysis of CYT-338 NK Cell Engager (NKE) Against CD38 Expressing Tumors Including Multiple Myeloma (MM)
Authors: Liang Lin, Hao-Ming Chang, Dennis Wu, Ben Titz, Amy Chen, Marshall Chao Ma, Preeti Ashok, David Zou, Nejmi Dilmac, Armand Bensussan, Jean Kadouche, Chorom Pak, Stanley Frankel, Daniel Teper, Wei Li, Antonio Arulanandam
Journal: Blood (2022)
Expression Signature and Prognostic Value of BCL2 Translocation for Diffuse Large B-Cell Lymphoma Patients in China
Authors: Yan Qin, Tian Qiu, Xinrui Chen, Peng Liu, Jianliang Yang, Xiaohui He, Lin Gui, Shengyu Zhou, Hongxin Jiang, Changgong Zhang, Sheng Yang, Le Tang, Yuankai Shi
Journal: Blood (2022)
The Potential of Extracellular Vesicle Derived microRNAs As a Biomarker in Acute Myeloid Leukemia
Authors: Ka-Won Kang, Jeong-An Gim, Kunye Kwak, Sunghoi Hong, Hyun Koo Kim, Yeonho Choi, Ji-ho Park, Yong Park
Journal: Blood (2022)
Clinical Features, Treatment Patterns, and Outcomes Among 837 Patients with Adult T-Cell Leukemia-Lymphoma in the Real-World Setting: A Comparison of Endemic Regions
Authors: Bryan Valcarcel, Haruhiko Sano, Hiroo Katsuya, Atae Utsunomiya, Maki Otsuka, Masaharu Miyahara, Yasushi Takamatsu, Kenji Ishitsuka, Shinya Kimura, Junji Suzumiya, Kazuo Tamura, Daniel J Enriquez, Denisse Castro, Brady E Beltran, Henry Idrobo, Camila Peña, Lorena Fiad, Juan Carlos Ramos, Luis Enrique Malpica Castillo
Journal: Blood (2022)
Targeting Transcriptional Kinase of CDK7 Halts Proliferation of Multiple Myeloma Cells By Modulating the Function of Canonical NF-Kβ Pathway and Cell Cycle Regulatory Proteins
Authors: Rudra Prasad Dutta, Rohit Kumar, Prashant R. Tembhare, Bhausaheb Bagal, Rajeeb Kumar Swain, Syed Khizer Hasan
Journal: Blood (2022)
A Phase 1b Open-Label Study of Loncastuximab Tesirine in Combination with Other Anticancer Agents in Patients with Relapsed or Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (LOTIS-7)
Authors: Brian T. Hess, Graham P. Collins, Melhem Solh, Mitul Gandhi, Ying Wang, Yajuan Qin, Eric Yu, Pier Luigi Zinzani
Journal: Blood (2022)
Isatuximab Plus Carfilzomib and Dexamethasone in Relapsed Multiple Myeloma: Ikema Subgroup Analysis By Number of Prior Lines of Treatment
Authors: Marcelo Capra, Thomas Martin, Philippe Moreau, Gracia Martinez, Albert Oriol, Youngil Koh, Hang Quach, Kwee Yong, Andreea Rawlings, Christina Tekle, Sandrine Macé, Marie-Laure Risse, Ivan Spicka
Journal: Blood (2022)
3-Year Follow-up Analysis of ZUMA-5: A Phase 2 Study of Axicabtagene Ciloleucel (Axi-Cel) in Patients with Relapsed/Refractory (R/R) Indolent Non-Hodgkin Lymphoma (iNHL)
Authors: Sattva S. Neelapu, Julio Chavez, Alison R. Sehgal, Narendranath Epperla, Matthew Ulrickson, Emanuel Bachy, Pashna N. Munshi, Carla Casulo, David G. Maloney, Sven de Vos, Ran Reshef, Lori A. Leslie, Olalekan O. Oluwole, Ibrahim Yakoub-Agha, Rashmi Khanal, Joseph D. Rosenblatt, Jiali Yan, Qinghua Song, Weixin Peng, Christine Lui, Jacob Wulff, Rhine R. Shen, Soumya Poddar, Harry Miao, Sara Beygi, Caron A. Jacobson
Journal: Blood (2022)
Venetoclax, Lenalidomide and Rituximab for Patients with Relapsed or Refractory Mantle Cell Lymphoma - the Nordic Lymphoma Group NLG-MCL7 (VALERIA) Phase Ib-II Trial
Authors: Mats Jerkeman, Arne Kolstad, Martin Hutchings, Annika Pasanen, Leo Meriranta, Carsten Utoft Niemann, Rasmus Rask Kragh Jørgensen, Tarec Christoffer Christoffer El-Galaly, Jon Riise, Sirpa Leppä, Jacob Haaber Christensen, Karin Fahl Wader, Ingrid Glimelius
Journal: Blood (2022)
Targeting the <i>WT1mut</i>-M<i>ir-193a</i> Transcriptional Axis with INT-1B3, a Novel Lipid Nanoparticle-Formulated Mir<i>-193a-3p</i> Mimic in Acute Myeloid Leukemia
Authors: Xining Yang, Kathrin Krowiorz, Raj Bhayadia, Jessica Kohlschmidt, Deedra Nicolet, Tobias Maetzig, Caroline Pabst, Jeremy Hui, Arshia Shad, Sharon Gao, Maria Stephenson, Si Wei Wu, Marion van den Bosch, Daelynn Buelow, Sharyn Baker, Leo Escano, Frances E Lock, Afsaneh Panahi, Liam MacPhee, Irina Maksakova, Amanda Amoah, Konstanze Döhner, Linda Fogelstrand, Ann-Kathrin Eisfeld, Sanaz Yahyanejad, Michel Janicot, Christopher C. Oakes, Jan-Henning Klusmann, Arefeh Rouhi, Florian Kuchenbauer
Journal: Blood (2022)
BCMA-Targeted, Hypoimmune Allogeneic CAR T Cells Exhibit Potent Anti-Tumor Activity Together with the Ability to Evade Innate and Adaptive Immune Rejection in Pre-Clinical Tumor Models
Authors: Jeremy M. Kinder, Chanel Athena-Estrada, Danyal Malik, Xiaomeng Hu, Meghan Lamba, Chi Young, Neal Van Hoeven, Brian Granger, Vandana Chaturvedi, Ouwen Liang, Jesus Moreno, Aaron Lampano, Garrett Zipp, Adam Johnson, Terry Fry, Sonja Schrepfer, Aaron Foster
Journal: Blood (2022)
Renal Response of Pomalidomide with Bortezomib and Dexamethasone in Newly Diagnosed Multiple Myeloma Patients with Renal Impairment: A Prospective, Open-Label, Multicenter, Phase 2 Study
Authors: Yuan Jian, Long Chang, Mingxia Shi, Ying Sun, Xiaoxia Chu, Hua Xue, Wenrong Huang, Xuliang Shen, Jie Ma, Guorong Jia, Yaqing Feng, Zhenfang Xi, Yanhong Zhao, Yanping Ma, Jing Xiao, Guangyu Ma, Qingming Wang, Li Bao, Yujun Dong, Hebing Zhou, Chunyan Sun, Guohong Su, Yan Yan, Saiyin Qimuge, Liping Su, Jingnan Sun, Weiwei Tian, Xiuli Sun, Hongmei Jing, Da Gao, Wenming Chen, Jian Li, Wen Gao
Journal: Blood (2022)
Risk of Endometrial Polyps, Hyperplasia, Carcinoma, and Uterine Cancer After Tamoxifen Treatment in Premenopausal Women With Breast Cancer
Authors: Ki-Jin Ryu, Min Sun Kim, Ji Yoon Lee, Seunghyun Nam, Hye Gyeong Jeong, Tak Kim, Hyuntae Park
Journal: JAMA Network Open (2022)

Importance The association of tamoxifen use with the risk of uterine diseases, such as endometrial cancer, in premenopausal women with breast cancer remains controversial. However, many studies have reported an increased risk of uterine disease among postmenopausal tamoxifen users. Objective To investigate the association of tamoxifen use with the risk of endometrial cancer and other uterine diseases in premenopausal women with breast cancer. Design, Setting, and Participants A nationwide, population-based, retrospective longitudinal cohort study with an 18-year study period was conducted using data obtained from the Korean National Health Insurance Service. Participants included premenopausal women aged 20 to 50 years with breast cancer diagnoses between January 2003 and December 2018. Data were analyzed from April to December 2021. Exposures Tamoxifen treatment. Main Outcomes and Measures The incidence of uterine diseases, including endometrial cancer, hyperplasia, polyps, and other uterine cancers, was identified in the study cohort using insurance claim codes. The incidence of uterine diseases per 1000 person-years was compared between women receiving tamoxifen and those not treated with adjuvant hormone therapy. Multivariable Cox proportional hazard regression analysis was performed to determine the risk of each uterine disease. Results Among 78 320 female participants with a mean (SD) age of 42.1 (6.1) years, 34 637 (44.2%) were categorized into the tamoxifen group and 43 683 (55.8%) were categorized into the control group. Among tamoxifen users, during the mean (SD) follow-up duration of 6.13 (4.15) years, the incidence of newly diagnosed endometrial polyps was 20.13 cases per 1000 person-years, that of endometrial hyperplasia was 13.49 cases per 1000 person-years, that of endometrial cancer was 2.01 cases per 1000 person-years, and that of other uterine cancers was 0.45 cases per 1000 person-years. The risk of endometrial cancer was higher in the tamoxifen group than in the control group (hazard ratio, 3.77; 95% CI, 3.04-4.66) after adjusting for age, body mass index, history of diabetes, hypertension, dyslipidemia, polycystic ovary syndrome, gonadotropin-releasing hormone agonist treatment, and trastuzumab treatment. Conclusions and Relevance In this longitudinal cohort study, premenopausal Korean women with breast cancer who received tamoxifen as adjuvant hormone therapy had a significantly increased risk of endometrial hyperplasia, polyps, carcinoma, and other uterine cancers compared with those who were not treated with adjuvant hormone therapy. These findings suggest that clinicians should consider the risk of uterine disease among tamoxifen users, including premenopausal women.
<i>ASXL1</i> Mutations Predict Inferior Molecular Response to Nilotinib Treatment in Newly Diagnosed Patients with Chronic Myeloid Leukemia in Chronic Phase
Authors: Thomas Ernst, Lioba Schönfeld, Jenny Rinke, Anna Hinze, Saskia N. Nagel, Vivien Schäfer, Thomas Schenk, Christian Fabisch, Tim H. Brümmendorf, Andreas Burchert, Philipp le Coutre, Stefan W. Krause, Susanne Saussele, Fatemeh Safizadeh, Markus Pfirrmann, Andreas Hochhaus
Journal: Blood (2022)
The Uncertain Effects of Surveillance Screening for COVID-19 for Individuals Entering Health Care Facilities
Authors: Eric Ward, Mitchell H. Katz
Journal: JAMA Internal Medicine (2022)

Scott C. Roberts, MD, MS; Ridwan N. Faruq, MBBS; Anne K. Wilkinson, MBA; Dinesh S. Pashankar, MD, MBA; Mark Russi, MD, MPH; Babar Khokhar, MD, MBA; Richard A. Martinello, MD
Elucidating the Molecular Mechanisms of Action of CC-99282, a Novel Cereblon (CRBN) E3 Ligase Modulator (CELMoD) Agent, Via Genome-Wide CRISPR Screen in a Preclinical Model of Non-Hodgkin Lymphoma (NHL)
Authors: Zhongying Mo, Lynda Groocock, Scott Wood, Diana Jankeel, Preethi Janardhanan, Derek Mendy, Michael Angelo, In Sock Jang, Celia Fontanillo, Kai Wang, Mark Rolfe, Antonia Lopez-Girona
Journal: Blood (2022)
Preliminary Safety of a Bcl-2 Inhibitor, Bgb-11417, in Patients with Relapsed/Refractory Multiple Myeloma Harboring t(11,14): A Non-Randomized, Open-Label, Phase 1b/2 Study
Authors: Hang Quach, Rajeev Rajagopal, Andrew Spencer, Michael Low, Dickran Kazandjian, Rocco Crescenzo, Chenmu Du, Sheel Patel, Vaibhav Mundra, Huan Cheng, Binod Dhakal
Journal: Blood (2022)
Trial in Progress: Randomized, Double-Blind, Placebo-Controlled Multicenter Phase 3 Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Patients with Cold Agglutinin Disease (CASCADE)
Authors: Bernd Jilma, Eloy Roman, Yasutaka Ueda, Silvia Mappa, Johan Szamosi, Jessica Savage, Alexander Roeth
Journal: Blood (2022)
The Novel Scoring System to Personalize the Conditioning Intensity in Elderly Patients
Authors: Yu Akahoshi, Yuma Tada, Emiko Sakaida, Machiko Kusuda, Noriko Doki, Naoyuki Uchida, Takahiro Fukuda, Masatsugu Tanaka, Masashi Sawa, Yuta Katayama, Ken-ichi Matsuoka, Yukiyasu Ozawa, Makoto Onizuka, Junya Kanda, Yoshinobu Kanda, Yoshiko Atsuta, Hideki Nakasone
Journal: Blood (2022)
Streamline - Retrospective Cohort Study of <i>FLT3-</i>mutated Acute Myeloid Leukemia (AML): Real-World Treatment Patterns and Clinical Outcomes after First Relapse or Refractory (R/R) Diagnosis
Authors: Amer M. Zeidan, Santosh Gautam, Rebekah Yu, Ziyu Lan, David L. Grinblatt, Dina ElSouda, James Spalding, Alana Block, Maelys Touya, Bhavik J. Pandya
Journal: Blood (2022)
Clinical Characteristics of Chilean Adult Patients with Acute Myeloid Leukemia (AML): Analysis within the Framework of the Epidemiological Registry of AML of the Pethema Group
Authors: Alejandra Romero, Francisca Bass, Veronica Lizama, Christine Rojas, Javier Diaz, Marisa Capurro, Yaima Gutierrez, Matias Sanchez, Natalia Aránguiz, Marcela Espinoza, Maria Carolina Guerra, Sebastian Hidalgo, Joaquín Jerez, Pilar León, Bernardita Rojas, Ernesto Castaño, Denis Suarez Munoz, Vivianne Torres, Monica Paulina Fuentes, Miguel Lopez, Rocío Osorio, Belkys Mercedes Linares, Robert Holloway Melo, Paola Aravena, Patricia Fardella, Felipe Ramirez, Constanza Flores, Maria Soledad Urquieta, David Martinez-Cuadron, Pau Montesinos
Journal: Blood (2022)