tbuckley/cabot-search huggingface dataset:
AB0206 STUDY ON THE SIGNIFICANCE OF SERUM COMPLEMENT C5 IN PATIENTS WITH RHEUMATOID ARTHRITIS
Authors: J. Liu, Q. Zhou, X. Chen, H. Guo, L. Long
Journal: Annals of the Rheumatic Diseases (2022)

Background Recent studies have pointed out that complement system activation is a major alteration in early atherosclerotic plaques, and complement C5 has promising value as a novel circulating biomarker of atherosclerosis, but the relationship between C5 and carotid atherosclerotic (CAS) plaque in rheumatoid arthritis (RA) is still unclear. Objectives To investigate the clinical significance of serum complement C5 and the association with CAS plaque in patients with RA． Methods 143 patients with RA were included in the study, and 46 cases with age- and sex- matched healthy physical examination without RA or CAS plaque served as a normal control. All RA patients were divided into RA with CAS plaque group and RA without CAS plaque group according to the presence or absence of plaque formation in the carotid artery. The subject’s demographic data, laboratory investigations and serum samples were collected. Body mass index (BMI) and Disease Activity Score 28-joint counts (DAS28) were calculated. Glucocorticoid and DMARDS use were recorded in the past 3 months. ELISA method was used to determine the concentration of complement C5 in the serum of each participation. CAS plaque was determined by color Doppler ultrasound. Results Serum complement C5 in RA group was significantly lower than that in control group ( P &lt;0.05), whereas C5 level in RA with CAS plaque group was significantly higher than that in RA without CAS plaque group ( P &lt;0.05). In RA group, serum C5 level was positively correlated with CAS plaque, high-sensitivity C-reactive protein (hs-CRP) and fibrinogen (FIB) (r=0.204, P =0.017; r=0.225, P =0.009; r=0.186, P =0.029;). In addition, there was no significant correlation between serum C5 and sex, age, BMI, course of disease, DAS28, lipid profile (TG, serum triglyceride; TC, total cholesterol; LDLC, low density lipoprotein cholesterol; HDLC, high density lipoprotein cholesterol; TC/HDLC; LDLC/HDLC), immune markers (RF, rheumatoid factor; anti-CCP, anti-cyclic citrullinated peptide antibodies), cytokine (IL-6, Interleukin-6; TNF-α, Tumor necrosis factor-α), erythrocyte sedimentation rate (ESR) (all P &gt;0.05), or drug therapy (all P &gt;0.05). Conclusion C5 may be a novel circulating marker of atherosclerosis in RA patients, it might promise to assist in risk stratification for cardiovascular disease in the future. References [1]Martínez-López D, et al. Complement C5 Protein as a Marker of Subclinical Atherosclerosis. J Am Coll Cardiol. 2020 Apr 28;75(16):1926-1941. Disclosure of Interests None declared
AB1000 Reliability and Validity of the Cone Evasion Walk Test in Patients With Total Knee Arthroplasty: A Pilot Study
Authors: K. S. Kacmaz, B. Unver, V. Karatosun
Journal: Annals of the Rheumatic Diseases (2022)

Background Total knee arthroplasty (TKA) is the gold-standard procedure for end-stage knee osteoarthritis, however, some residuel problems may still continue and cause a variety of dysfunctions, such as impaired strength, proprioception, gait, balance, postural instability, and, impaired ability to avoid obstacles while walking. Tripping over an obstacle is the most frequent cause of falls 1 and falls can limit daily activities and induce post-fall syndromes, such as dependence, loss of autonomy, immobilization, and depression 2. The Cone Evasion Walk test (CEW) to assess fall risk by the ability to evade obstacles, (ICF-code d455), which requires attentional, perceptual, and several neuromusculoskeletal and movement related functions 3. However, there is no study investigating the reliability and validity of the CEW in TKA patients. Objectives The aim of the study is to investigate the reliability and validity of the CEW in patients with TKA. Methods Twenty patients with TKA included in the study. The CEW, the Timed Up And Go Test (TUG) and the Hospital for Special Surgery (HSS) Knee Score administered to the patients. Patients rested between the tests for an hour. Results Mean age was 68.1 ± 2.59 years and the mean HSS Knee Score was 85.43± 3.47. The relative (ICC coefficient) and absolute (SEM and SRD95) reliability values were 0.98, 1.01, and 2.75 respectively. The Spearman correlation coefficient of the CEW with the TUG was 0.72. Conclusion Based on the current findings, the CEW has excellent reliability, high validity and responsiveness in evaluating dynamic balance and obstacle avoidance in patients with TKA. The minimal clinically important difference of CEW in TKA patients is 2.75 and it may be concluded that the fact that this value is low, indicates the sensitivity of the test. Therefore, the CEW can identify even small alterations in the functional status, can be reliably used for post-operative surveillance of TKA to observe patient results, and the usage of the CEW for assessing the fall risk and mobility in the community may be a better predictor of the patients’ current condition. References [1]Mauer AC, Draganich LF, Pandya N, Hofer J, Piotrowski GA. Bilateral Total Knee Arthroplasty Increases the Propensity to Trip on an Obstacle. Clinical Orthopaedics and Related Research. 2005;NA;(433):160-165. doi:10.1097/01.blo.0000150569.93262.64 [2]Park SH. Tools for assessing fall risk in the elderly: a systematic review and meta-analysis. Aging Clinical and Experimental Research. 2018;30(1):1-16. doi:10.1007/s40520-017-0749-0 [3]Sjöholm H, Hägg S, Nyberg L, Rolander B, Kammerlind AS. The Cone Evasion Walk test: Reliability and validity in acute stroke. Physiotherapy Research International. 2019;24(1):e1744. doi:10.1002/pri.1744 Disclosure of Interests None declared
POS1319 RISK OF CORONARY ARTERY INVOLVEMENT IN KAWASAKI DISEASE.
Authors: S. Kurbanova, M. Kantemirova, Y. Y. Novikova, D. Ovsyannikov
Journal: Annals of the Rheumatic Diseases (2022)

Background Kawasaki disease (KD) is a nonspecific systemic vasculitic disease that frequently occurs among children, and coronary artery lesion (CAL) is the most serious complication Objectives We aimed to study the risk factors for CAL in children with KD Methods There were examined 188 patients (boys:girls – 2:1, median age Me = 24 months [11;38]) with KD hospitalized in Morozovskaya Children’s City Clinical Hospital in 2014-2019. 19 (10,1%) of them were &lt;6 months, 29 (15,4%) - 6-&lt;12 months, 117 (62,3%) - 12 months-&lt;5 years, 23 (12,2%) - ≥5 years. Univariate and multivariate logistic regression analyses were conducted to explore the relationships between CAL and gender, age, clinical diagnosis, laboratory biomarkers, initiation time of IVIG administration. Results The enrolled 188 KD children were divided into a CAL group (n = 61) and an NCAL group (n =127) according to cardiac color Doppler ultrasonography. The incidence rate of CAL in the acute period was 26 %. The two groups had significantly different gender (p=0,0184), initiation time of IVIG administration (p=0,0209;)increase in platelets more than 700 000 at 2 weeks (p=0,0089), higher levels of NT-proBNP (p=0.002) and proANP (p=0,0005). Patients with CAL were found to have higher levels of NT-proBNP and proANP, suggesting a prognostic role. The NT-proBNP level was significantly higher in patients with CAL, and a cutoff value of 984 pg/mL yielded a sensitivity and specificity of 79 and 84.8 %, respectively. The area under the curve of the NT-proBNP for predicting CAA was 0.794 (95 % CI 0.620-0.967). The proANP level was significantly higher in patients with CAL, and a cutoff value of 1.015 nmol/L yielded a sensitivity and specificity of 87.5 and 75.8 %, respectively. The area under the curve of the proANP for predicting CAA was 0.805 (95 % CI 0.656-0.954). Conclusion Male gender, delayed use of IVIG, high platelets, NT-proBNP, proANP were independent risk factors for KD complicated with CAL. Current evidence suggests that NT-proBNP and proANP may be used as a diagnostic tool for KD complicated with CAL Disclosure of Interests None declared
Life’s Essential 8: Updating and Enhancing the American Heart Association’s Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association
Authors: Donald M. Lloyd-Jones, Norrina B. Allen, Cheryl A.M. Anderson, Terrie Black, LaPrincess C. Brewer, Randi E. Foraker, Michael A. Grandner, Helen Lavretsky, Amanda Marma Perak, Garima Sharma, Wayne Rosamond
Journal: Circulation (2022)

In 2010, the American Heart Association defined a novel construct of cardiovascular health to promote a paradigm shift from a focus solely on disease treatment to one inclusive of positive health promotion and preservation across the life course in populations and individuals. Extensive subsequent evidence has provided insights into strengths and limitations of the original approach to defining and quantifying cardiovascular health. In response, the American Heart Association convened a writing group to recommend enhancements and updates. The definition and quantification of each of the original metrics (Life’s Simple 7) were evaluated for responsiveness to interindividual variation and intraindividual change. New metrics were considered, and the age spectrum was expanded to include the entire life course. The foundational contexts of social determinants of health and psychological health were addressed as crucial factors in optimizing and preserving cardiovascular health. This presidential advisory introduces an enhanced approach to assessing cardiovascular health: Life’s Essential 8. The components of Life’s Essential 8 include diet (updated), physical activity, nicotine exposure (updated), sleep health (new), body mass index, blood lipids (updated), blood glucose (updated), and blood pressure. Each metric has a new scoring algorithm ranging from 0 to 100 points, allowing generation of a new composite cardiovascular health score (the unweighted average of all components) that also varies from 0 to 100 points. Methods for implementing cardiovascular health assessment and longitudinal monitoring are discussed, as are potential data sources and tools to promote widespread adoption in policy, public health, clinical, institutional, and community settings.
AB0730 SCCA-IgM as a predictor of interstitial lung disease progression in systemic sclerosis
Authors: E. Zanatta, A. Martini, A. Cuberli, A. Biasiolo, P. Pontisso, A. Doria
Journal: Annals of the Rheumatic Diseases (2022)

Background Interstitial Lung Disease (ILD) is the major determinant of morbidity and mortality in patients with systemic sclerosis (SSc). The course of lung involvement is extremely variable in SSc-ILD. Squamous Cell Carcinoma Antigen 1 (SCCA1) is a cysteine protease inhibitor that plays a crucial role in inflammation and fibrosis. It may be detected in serum in the form of an IgM-linked immune complex (SCCA-IgM), and we previously demonstrated that it is increased in patients with SSc-ILD (1). Objectives We aimed to investigate the association between SCCA-IgM serum levels and ILD progression in a cohort of SSc patients. Methods Ninety-seven patients with SSc (2013 ACR/EULAR criteria) from the Rheumatology Unit of Padua University Hospital were consecutively enrolled in the study. Clinical, serological indices and organ involvement (pulmonary, cardiac, gastrointestinal and articular) were evaluated at the time of the SCCA-IgM assay. Pulmonary involvement was investigated by high-resolution CT (HRCT) and respiratory function tests (PFTs). Serum immune complex levels were measured by a validated ELISA assay (Hepa-IC, Xeptagen, Venice, Italy) and expressed in arbitrary units/mL (AU/mL). Follow-up period was defined as the time between baseline (i.e. SCCA-IgM blood sampling) and last PFTs and/or HRCT performed at least after 24 months. SSc-ILD progression was defined by HRCT and/or PFTs worsening. Progression on PFTs: FVC decline ≥ 10% from baseline or FVC ≥ 5-9% decline plus DLCO decline ≥ 15%; radiological progression: ILD worsening on HRCT evaluated by the same experienced thoracic radiologist. Results Among the 97 SSc enrolled patients (mean age 55.4±12.5 yrs), 82 (84.5%) were female, 35 (36%) affected by diffuse cutaneous form of SSc (dcSSc) and 41 (42.3%) had ILD diagnosed by HRCT. The mean follow-up was 34.6 ± 1.8 months, with PFTs and/or HRCT data available in 86 patients, 37 (43%) of whom had ILD at baseline. Patients with ILD who progressed during follow-up were more frequently affected by dcSSc (p = 0.003), and tended to have lower values of total lung capacity (p=0,091). The median SCCA-IgM values were significantly higher in patients with progressive ILD vs. those with stable ILD: 301 (57-526) vs. 45 (34-236), respectively (p = 0.017), Figure 1. At Cox regression multivariate analysis, SCCA-IgM serum levels was the only variable independently associated with ILD progression [HR 1,003 95% CI 1,000-1,006, p=0.02]. Conclusion In conclusion, our preliminary data support SCCA-IgM as a potential candidate biomarker for progressive ILD in patients with scleroderma. References [1]Zanatta E et al, Joint Bone Spine 2020;87:331-335. Disclosure of Interests None declared
POS1313 HIP INVOLVEMENT IS A MORE FREQUENT COMPLICATION IN ENTHESITIS-RELATED ARTHRITIS COMPARING TO THE ADULT SPONDYLARTHRITIS
Authors: C. Ines, H. Ferjani, L. Ben Ammar, D. Ben Nessib, W. Triki, K. Maatallah, D. Kaffel, W. Hamdi
Journal: Annals of the Rheumatic Diseases (2022)

Background The hip disease develops in 30% to 50% of children with juvenile idiopathic arthritis (JIA) and is associated with poor outcomes and functional impairment. The coxitis in enthesitis-related arthritis (ERA or juvenile-onset spondyloarthritis) patients was frequent but weakly studied. Objectives To assess the occurrence of coxitis in patients with ERA and compare it to that of older patients with spondyloarthritis (SpA). Methods We conducted a retrospective comparative study including patients with ERA and adult spondyloarthritis patients. The first group included patients under 16 years old fulfilling the International League of Associations for Rheumatology (ILAR). The second group of patients fulfilled the Assessment of SpondyloArthritis International Society (ASAS) 2009 criteria. We studied the socio-demographic characteristics of both groups, the hip involvement occurrence, and the treatment modalities. Quality of life was appraised by the Study 36-item Short-Form Health Survey (SF-36) and the Ankylosing spondylitis quality of life test (ASQOL). Results Forty ERA (mean age= 25,3 ± 10,15) patients and 134 SpA (mean age=37,96±11,77) patients were enrolled. Seventeen ERA patients (42,5%) had coxitis at recruitment compared to 28 SpA patients (20,9%), p=0,06. More than half of the ERA patients were positive to HLAb27, compared to the SpA group (44,7%) without reaching a significant threshold, p=0,07. The mean delay of coxitis onset in ERA patients was 4,66 ± 8,46 years, and was 5,65 ± 6,85 years in SpA patients, with no significant difference between the two groups (p=0,527). There was no difference between the two groups for the coxitis being unilateral or bilateral (p=0,272 and 0,169 respectively). Regarding the treatment approach, local therapy was proposed to 11 patients in the ERA group and 13 patients in the SpA group (p=0,07), with synoviorthesis being the most common therapy. Total hip replacement was done in 8 ERA patients (of which seven were bilateral) and in 17 SpA patients (of which ten were bilateral), without reaching the significant threshold (p=0,858). There was no significant difference between the two groups on the period when the total hip replacement was done (p=0,925). Quality of life assessed by the ASQOL and the SF-36 was comparable between the two groups (p=0,666 and 0,326; respectively). Conclusion Our study shows the high prevalence of hip involvement in the juvenile group of SpA. This complication occurs within the five years of disease outcomes and constitutes a turning point in their lives. Disclosure of Interests None declared
AB0175 THE ROLE OF MONITORING THE CYTOKINE PROFILE TO PREDICT THE EFFECTIVENESS OF THERAPY IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS
Authors: A. Avdeeva, V. Rybakova, E. Nasonov
Journal: Annals of the Rheumatic Diseases (2022)

Background: Objectives To evaluate the changes in cytokine profile in methotrexate (MTX)-naive patients (pts) with early rheumatoid arthritis (RA) during MTX therapy and identify predictors of the effectiveness of therapy. Methods The study included 45 early RA DMARD-naive pts (35 females, 10 males with median age 53.5; interquartile range 46-59.5 years, disease duration 7.0;4.0-11.5 months, DAS 28 5.8;4.9-6.4, RF positive 91%, anti-CCP positive 96%). MTX was administered to all patients as the first-line DMARD at 10 mg/week with a rapid escalation of the dose up to 20-25mg/week. The levels of IL-1b, IL-1Рa, IL-2,-4,-5,-6,-7,-8,-9,-10,-12,-13,-15,-17, Eotaxin, FGF-basic, IFN-γ, IP-10, MCP-1, MIP-1α, MIP-1β, RANTES, TNF-α, VEGF (pg/ml) were tested by multiplex technology xMAP at baseline and weeks 12 and 24. Results After 3 months the efficacy of SC MTX have met the goal in 23(51%) of pts. MTX induced reduction in proinflammatory (IL-6,-17,TNF-α), anti-inflammatory (IL-4,-5,-9,-13) cytokines, chemokines (IP-10) and growth factors (FGF) at week 12; IL-6,-9, IP-10, PDGF-bb at week 24 (p&lt;0.05). The serum levels of IL-10, IFN-γ increased at week 24 (p&lt;0.05), Figure 1. Among the “respondents” to MT therapy, by week 12, a significant decrease in levels of IL-1Ra, IL-2,-4,-6,-7,-9,-13, IP-10, TNF-α, VEGF was detected. In the “non-responders” group, the level of cytokine profile indices did not change (p&gt;0.05), Figure 2. Conclusion Clinical efficacy of SC MTX therapy is associated with reduced of proinflammatory cytokines, chemokines and growth factors at weeks 12-24 of therapy. The dynamics of cytokine profile after 12 weeks of MT therapy can be considered as a predictor of the effectiveness of MT therapy. Disclosure of Interests None declared
POS1536-HPR THE RELATIONSHIP BETWEEN POSTURAL CHANGES AND TRUNK MUSCLE ENDURANCE IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS
Authors: A. C. Kalkan, G. Duran, S. Ozyurek, D. Bayraktar, H. Adiguzel Dundar, E. Unsal, A. Genc
Journal: Annals of the Rheumatic Diseases (2022)

Background Body posture is defined as relative biomechanical alignment of body’s head, trunk, and extremities as well as position of the body in the space. Body posture might be altered due to different musculoskeletal pathologies. Juvenile Idiopathic Arthritis (JIA) is a chronic inflammatory disease characterized by musculoskeletal problems including bone and muscle geometry alterations which may lead a deteriorated posture. However, it is not known whether trunk muscle endurance is associated with body posture in children with JIA. Objectives To investigate the relationship between postural changes and trunk muscle endurance in children with JIA. Methods Thirty-four children (eighteen female, sixteen male) were included in the study. Postural changes were assessed by a three-dimensional evaluation system (PosturePrint System, Biotonix, Canada). The system provides Posture Index (PI) score which is a composite score from three postural regions including head, ribcage, and pelvis. Higher PI scores indicate a more deteriorated posture. Biering–Sørensen Test (BST), Flexor Endurance Test (FET), Lateral Endurance Test (LET) were used to assess trunk muscle endurance, and Static Scapular Endurance Test (SSET) were used to assess scapular muscle endurance. Spearman Rank Correlation test was employed to determine the possible relationships. Results Enthesitis related arthritis was the most common JIA subtype in the study (38.2%) followed by oligoarthritis (26.5%), polyarthritis (20.6%), and systemic arthritis (14.7%). Significant negative correlations were detected between SSET and PI-head score (rho= -0.467, p=0.005), SSET and PI-ribcage score (rho= -0.381, p=0.026); FET and PI-head score (rho= -0.469, p=0.005); LET and PI-head score (rho= -0.441, p=0.009). Table 1. Demographics, muscle endurance and Posture Index scores of children Variable Median (IQR 25 th /75 th ) Age (years) 12.0 (10.0/14.0) Height (cm) 145.50 (140.00/158.25) Weight (kg) 42.75 (33.00/49.50) Body mass index (kg/m 2 ) 19.17 (16.09/21.42) Biering– Sørensen Test (sec) 49.70 (28.42/80-78) Flexor Endurance Test (sec) 38.91 (30.59/60.19) Lateral Endurance Test (sec) 32.52 (19.99/59.68) Static Scapular Endurance Test (sec) 23.19 (15.93/44.74) Posture Index-Head (score) 7.0 (5.0/8.0) Posture Index-Ribcage (score) 5.0 (4.0/6.0) Posture Index-Pelvis (score) 6.0 (3.0/8.0) IQR: Interquartile range Conclusion These results indicated that postural displacements of head and ribcage are linked with decreased trunk and scapular muscle endurance in children with JIA. Exercise and physical activity programs targeting muscle endurance may result improvements in posture in these children. Disclosure of Interests None declared
AB1257 INVESTIGATING THE ASSOCIATIONS BETWEEN THE MAXIMAL RESPIRATORY PRESSURES AND CARDIORESPIRATORY FITNESS PARAMETERS IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS
Authors: D. C. Saraç, D. Bayraktar, D. Ozer Kaya, O. Altug-Gucenmez, D. Oskay
Journal: Annals of the Rheumatic Diseases (2022)

Background The most prominent symptom of juvenile idiopathic arthritis (JIA) is joint involvement; however, the effect of the disease is not limited to the joints. Evidence suggests that cardiopulmonary fitness is affected in children with JIA compared to their healthy peers [1]. Objectives This study aimed to investigate the associations between the maximal respiratory pressures and cardiorespiratory fitness parameters. Methods Seventeen children with JIA (mean age: 15.4±2.2 years, 11 male) who have been using biological agents for at least three months were included in the study. Maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) were evaluated with a portable device (Cosmed Pony FX Desktop Spirometer, USA). The Quark Cardiopulmonary Exercise Test Treadmill System (COSMED, Rome, Italy) was employed to analyze cardiorespiratory fitness parameters by using expired gas collection and analysis. Results Significant moderate correlations were detected between MIP and maximum oxygen consumption (VO 2max) values (r=0.519, p=0.033) and MEP and VO 2max values (r=0.507, p=0.038), (Table 1). No other significant correlations were observed between maximal respiratory pressures and other parameters. Table 1. The associations between maximal respiratory pressures and cardiorespiratory fitness parameters n:17 MIP (cmH 2 O) (r ) p MEP (cmH 2 O) (r ) P VO 2max (ml/kg/min ) 0.519 0.033* 0.507 0.038* METs (ml/kg/min ) 0.276 0.283 0.298 0.246 HR (bpm ) 0.285 0.268 0.184 0.479 VO2/HR 0.456 0.066 0.479 0.052 PETCO 2max (mmHg ) 0.416 0.097 0.358 0.158 PETO 2max (mmHg ) -0.284 0.269 -0.158 0.544 *: p &lt;0.05, Pearson Correlation Coefficients , VO 2max : Maximum oxygen consumption, ml: milliliters , kg : kilograms, min: minute, METs: Metabolic equivalent HR: Heart rate, bpm: beats per minute, VO 2 /HR: Oxygen consumption/heart rate, PETCO 2 : Tidal partial pressure for carbon dioxide, PETO 2 : Tidal partial pressure for oxygen. Conclusion The results of the study suggest that maximal respiratory pressures are associated with maximal oxygen consumption. Evaluating maximal respiratory pressures might be helpful when prescribing exercise programs for JIA patients with diminished cardiorespiratory fitness. References [1]Richardson AE, Warrier K, Vyas H (2016). Respiratory complications of the rheumatological diseases in childhood. Arch Dis Child 101(8):752-758. https://doi.org/10.1136/archdischild-2014-306049 Disclosure of Interests None declared