A deep learning system for detection of early Barrett's neoplasia: a model development and validation study
Authors: K N Fockens, M R Jong, J B Jukema, T G W Boers, C H J Kusters, J A van der Putten, R E Pouw, L C Duits, N S M Montazeri, S N van Munster, B L A M Weusten, L Alvarez Herrero, M H M G Houben, W B Nagengast, J Westerhof, A Alkhalaf, R C Mallant-Hent, P Scholten, K Ragunath, S Seewald, P Elbe, F Baldaque-Silva, M Barret, J Ortiz Fernández-Sordo, G Moral Villarejo, O Pech, T Beyna, F van der Sommen, P H de With, A J de Groof, J J Bergman, Alaa Alkhalaf, Lorenza Alvarez Herrero, Francisco Baldaque-Silva, Maximilien Barret, Jacques J Bergman, Torsten Beyna, Raf Bisschops, Tim G Boers, Wouter Curvers, Pierre H Deprez, Lucas C Duits, Peter Elbe, Jose M Esteban, Gary W Falk, Kiki N Fockens, Eric Ganguly, Gregory G Ginsberg, Albert J de Groof, Rehan Haidry, Martin H Houben, Anthony Infantolino, Prasad G Iyer, Martijn R Jong, Pieter-Jan De Jonge, Jelmer B Jukema, Arjun K Koch, Srinadh Komanduri, Vani Konda, Carolus H J Kusters, Philippe Leclercq, Cadman L Leggett, Arnaud Lemmers, Charles J Lightdale, Rosalie C Mallant-Hent, Guiomar Moral Villarejo, V Raman Muthusamy, Wouter Nagengast, Jacobo Ortiz Fernández-Sordo, Oliver Pech, Ian Penman, Douglas K Pleskow, Roos E Pouw, Joost A van der Putten, Krish Ragunath, Pieter Scholten, Stefan Seewald, Amritha Sethi, Michael S Smith, Fons Van der Sommen, Arvind Trindade, Sachin Wani, Irving Waxman, Jessie Westerhof, Bas L Weusten, Peter H N de With, Herbert C Wolfsen
Journal: The Lancet Digital Health (2023)

BackgroundComputer-aided detection (CADe) systems could assist endoscopists in detecting early neoplasia in Barrett's oesophagus, which could be difficult to detect in endoscopic images. The aim of this study was to develop, test, and benchmark a CADe system for early neoplasia in Barrett's oesophagus.MethodsThe CADe system was first pretrained with ImageNet followed by domain-specific pretraining with GastroNet. We trained the CADe system on a dataset of 14 046 images (2506 patients) of confirmed Barrett's oesophagus neoplasia and non-dysplastic Barrett's oesophagus from 15 centres. Neoplasia was delineated by 14 Barrett's oesophagus experts for all datasets. We tested the performance of the CADe system on two independent test sets. The all-comers test set comprised 327 (73 patients) non-dysplastic Barrett's oesophagus images, 82 (46 patients) neoplastic images, 180 (66 of the same patients) non-dysplastic Barrett's oesophagus videos, and 71 (45 of the same patients) neoplastic videos. The benchmarking test set comprised 100 (50 patients) neoplastic images, 300 (125 patients) non-dysplastic images, 47 (47 of the same patients) neoplastic videos, and 141 (82 of the same patients) non-dysplastic videos, and was enriched with subtle neoplasia cases. The benchmarking test set was evaluated by 112 endoscopists from six countries (first without CADe and, after 6 weeks, with CADe) and by 28 external international Barrett's oesophagus experts. The primary outcome was the sensitivity of Barrett's neoplasia detection by general endoscopists without CADe assistance versus with CADe assistance on the benchmarking test set. We compared sensitivity using a mixed-effects logistic regression model with conditional odds ratios (ORs; likelihood profile 95% CIs).FindingsSensitivity for neoplasia detection among endoscopists increased from 74% to 88% with CADe assistance (OR 2·04; 95% CI 1·73–2·42; p<0·0001 for images and from 67% to 79% [2·35; 1·90–2·94; p<0·0001] for video) without compromising specificity (from 89% to 90% [1·07; 0·96–1·19; p=0·20] for images and from 96% to 94% [0·94; 0·79–1·11; ] for video; p=0·46). In the all-comers test set, CADe detected neoplastic lesions in 95% (88–98) of images and 97% (90–99) of videos. In the benchmarking test set, the CADe system was superior to endoscopists in detecting neoplasia (90% vs 74% [OR 3·75; 95% CI 1·93–8·05; p=0·0002] for images and 91% vs 67% [11·68; 3·85–47·53; p<0·0001] for video) and non-inferior to Barrett's oesophagus experts (90% vs 87% [OR 1·74; 95% CI 0·83–3·65] for images and 91% vs 86% [2·94; 0·99–11·40] for video).InterpretationCADe outperformed endoscopists in detecting Barrett's oesophagus neoplasia and, when used as an assistive tool, it improved their detection rate. CADe detected virtually all neoplasia in a test set of consecutive cases.FundingOlympus.