AB1203 EVALUATION OF THE URIC ACID AND HEMATOLOGICAL PARAMETERS IN PATIENTS WITH NODAL HAND OSTEOARTHRITIS
Authors: A. Ünal Engİnar
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Osteoarthritis (OA) is the most commonly seen joint disease worldwide. The frequency of OA is increased together with an increase in obesity and ageing. The hand is one of the most frequently involved areas, and hand OA is seen more often in females. <h3>Objectives</h3> To compare patients with symptomatic nodal hand osteoarthritis (OA) with a control group in respect of inflammation parameters, uric acid, and hematological parameters. <h3>Methods</h3> The study included 50 post-menopausal female patients, aged 40-80 years, diagnosed with symptomatic nodal hand OA, and a control group of 50 post-menopausal females in the same age range with no hand OA. Patient data including age, monocyte, neutrophil, lymphocyte, and thrombocyte counts, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, uric acid level, and the Kellgren-Lawrence (KL) score obtained from evaluations of hand radiographs, were recorded retrospectively from the hospital information system. The neutrophil-lymphocyte ratio (NLR), thrombocyte-lymphocyte ratio (PLR) were calculated. The data were compared between the two groups. <h3>Results</h3> The data of 100 females were compared, comprising a patient group of 50 patients with symptomatic nodal OA, and a control group of 50 females. Age, monocyte, neutrophil, lymphocyte, and thrombocyte counts, NLR, PLR, ESR, CRP, and uric acid level were compared. With the exception of ESR, no statistically significant difference was determined between the two groups. The ESR was determined to be statistically significantly higher in the patient group than in the control group (p&lt;0.001). When patients with a KL score of 2 and 3 were compared, with the exception of age, no other difference was determined. Patients with a KL score of 3 were seen to be significantly older (p:0.032). <h3>Conclusion</h3> ESR was determined to be significantly higher in patients with symptomatic nodal OA. Clarification of the relationship between inflammation, uric acid, and hand OA, which is a heterogeneous disease, will be useful in the follow-up and treatment of patients. <h3>References</h3> [1]Hunter DJ, Bierma-Zeinstra S. Osteoarthritis. Lancet. 2019 Apr 27;393(10182):1745-1759. doi: 10.1016/S0140-6736(19)30417-9. PMID: 31034380. [2]Marshall, M., Watt, F. E., Vincent, T. L.,Dziedzic, K. Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management. Nature Reviews Rheumatology, 2018;14(11), 641-656. [3]Zhang Y, Niu J, Kelly-HayesM, Chaisson CE, Aliabadi P, Felson DT. Prevalence of symptomatic hand osteoarthritis and its impact on functional status among the elderly: the Framingham study.Am J Epidemiol. 2002;156(11):1021–7. [4]Robinson WH, Lepus CM, Wang Q, Raghu H, Mao R, Lindstrom TM, Sokolove J. Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2016; 12:580–592. [5]Berenbaum F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!) Osteoarthritis Cartilage. 2013;21:16–21. [6]Favero, M.; Belluzzi, E.; Ortolan, A.; Lorenzin, M.; Oliviero, F.; Doria, A.; Scanzello, C.R.; Ramonda, R. Erosive hand osteoarthritis:Latest findings and outlook. Nat. Rev. Rheumatol. 2022, 18, 171–183 [7]Ding, X., Zeng, C., Wei, J., Li, H., Yang, T., Zhang, Y.,&amp; Lei, G. H. (2016). The associations of serum uric acid level and hyperuricemia with knee osteoarthritis. Rheumatology international, 36(4), 567-573. [8]Gao, K., Zhu, W., Liu, W., Ma, D., Li, H., Yu, W. &amp; Jiang, Y. Diagnostic value of the blood monocyte–lymphocyte ratio in knee osteoarthritis. Journal of International Medical Research,2019; 47(9), 4413-4421. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.