tbuckley/cabot-search huggingface dataset:
Family Studies in Tuberous Sclerosis
Authors: Suzanne B. Cassidy
Journal: JAMA (1983)

A family study was conducted to evaluate the apparently unaffected parents of 13 patients with tuberous sclerosis. None of the parents had a personal or family history suggesting the diagnosis of tuberous sclerosis. All 26 parents were examined according to a protocol that entailed medical history, physical examination (including Wood's lamp examination of the skin), funduscopic examination through a dilated pupil, roentgenograms of the hands, feet, and skull, renal ultrasound studies, and cranial computed tomography (CT). In these 13 families, three fathers and one mother had previously undiagnosed tuberous sclerosis. Three of the four had skin changes, three had calcifications shown by CT, and one had renal cysts. These data demonstrate the importance of detailed examination of all parents of patients with tuberous sclerosis before recurrence-risk counseling is given. (<i>JAMA</i>1983;249:1302-1304)
Nutrition and Diet in Health and Disease.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chemoprophylaxis of malaria in Africa.
Authors: W A Hart
Journal: BMJ (1983)

Professor L J Bruce-Chwatt successfully underlined the complexity of the problem of drug-resistant malaria and showed that some conflicting opinions exist among members of the medical profession regarding the antimalarial drugs to be used for chemoprophylaxis.Resistance of Plasmodium falciparum to chloroquine in Africa, especially in East Africa, must be recognised as an established fact.It has been found
On the Formation of the Hydrochloric Acid in the Gastric Tubules of the Vertebrate Stomach.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A reticulate vascular abnormality in patients with lymphoedema: observations in eight patients
Authors: N.H. COX, W.D. PATERSON, A.W. POPPLE
Journal: British Journal of Dermatology (1996)

We describe eight patients with lymphoedema who had prominent compressible ridges of tissue in a reticulate pattern, situated predominantly on the upper part of the lower leg. In five patients the lymphoedema was primary, two patients had circumferential venous ulceration, and one had marked venous disease with a small ulcer. One patient had a squamous cell carcinoma of the medial thigh and dysplastic keratoses in the distribution of the reticulate ridges. In three of the four cases in whom histological examination of the ridges was performed, the skin at these areas was demonstrated to contain grossly dilated angular vessels in the mid‐dermis, many with valves visible. The vessel walls had a single layer of endothelial cells (anti‐factor VIII‐related antigen positive) and a basement membrane containing type IV collagen. Abnormal elastic tissue in these biopsies was similar to that in erythema ab igne. Indirect lymphography in one case did not demonstrate dilated lymphatic vessels. The body site distribution and clinical pattern of the abnormality appeared to be similar to erythema ab igne but associated with an underlying abnormality of lymphatic rather than blood vasculature. We propose that our cases may represent 'lymphoedema ab igne'.
MACROSOMY DESPITE WELL-CONTROLLED DIABETIC PREGNANCY
Authors: George Russell, George Farmer, DavidJ. Lloyd, DonaldW.M. Pearson, IainS. Ross, JohnM. Stowers, HamishW. Sutherland, G.H.A. Visser, E. Van Ballegooie, W.J. Sluiter, HenriA. Verhaaren, Margarita Craen, Patrick De Gomme, Robert Rubens, Walter Parewijck, Robert Derom
Journal: The Lancet (1984)
A History of the London Hospital.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infant Mortality Reexamined
Authors: Nigel Paneth
Journal: JAMA (1982)

Comparisons of the infant mortality rates of different countries have a long and not especially noble history, political mudslinging often taking precedence over scientific inquiry. The United States has traditionally fared poorly in such comparisons, although lately the Soviet Union, whose infant mortality may actually be on the rise, has been a more prominent target of the political diatribe.<sup>1</sup> As infant mortality is closely tied to indices of social disadvantage, it is nonetheless paradoxical that the United States, for all its industrial wealth and technological resources, can do no better than a tie for 16th in the international infant mortality rankings.<sup>2</sup>There is no consensus as to why this is so, and it has never been clear what role medical care, or its lack, plays in it. However, a spate of recent work, of which the article by Erickson and Bjerkedal in this issue (p 987) is an
Outpatient Treatment of Hyperactive School Children with Imipramine
Authors: JONAS WAIZER, STANLEY P. HOFFMAN, POLIZOES POLIZOS, DAVID M. ENGELHARDT
Journal: American Journal of Psychiatry (1974)

Nineteen hyperactive school children were treated in an outpatient clinic with imipramine for eight weeks, followed by four weeks of placebo. On the basis of ratings by a child psychiatrist, parents, and teachers, significant improvement was observed in hyperactivity as well as in defiance, inattentiveness, and sociability. Placebo treatment resulted in deterioration of behavior. The side effects of anorexia and insomnia were reported but represented no serious problem. The unique effects of imipramine and its advantages over central nervous systern stimulants in the treatment of hyperactive children are discussed.
CDC's Approach to Firearm Injuries
Authors: Patrick O'Carroll
Journal: JAMA (1989)

<h3>To the Editor.—</h3> I am writing in regard to the article entitled "Epidemiologists Aim at New Target: Health Risk of Handgun Proliferation,"<sup>1</sup>which I do not believe accurately portrays either my approach to injury prevention research or that of the Centers for Disease Control (CDC). The National Academy of Sciences, in two recent reports, called for renewed national commitment to injury prevention and recommended that the CDC organize and coordinate the nation's injury control activities. Congress responded to the National Academy of Sciences recommendations and, in 1986, passed the Injury Prevention Act, which charged the CDC with the following responsibilities: (1) to promote and support research into the causes, treatment, prevention, and rehabilitation of injuries; (2) to promote cooperation among specialists in the many fields involved in injury research and prevention; and (3) to promote coordination among the numerous organizations and agencies involved in injury research and prevention. More
Statewide Surveillance for Ehrlichiosis—Connecticut and New York, 1994-1997
Journal: JAMA (1998)

In the United States, human monocytic ehrlichiosis (HME) and human granulocytic ehrlichiosis (HGE) represent two clinically indistinguishable yet epidemiologically and etiologically distinct diseases caused by Ehrlichia chaffeensis and a bacterium similar or identical to E. equi, respectively. Infection with these emerging tickborne pathogens results in acute, influenza-like illnesses with fever, headache, malaise, and frequently leukopenia and/or thrombocytopenia. Connecticut and New York have initiated statewide laboratory-based surveillance to determine the magnitude and geographic extent of ehrlichiosis. This report summarizes results from the first 3 years of surveillance, which showed that rates of ehrlichiosis were similar in counties in both states where the disease occurs, and highest age-specific rates occurred among persons aged >40 years.
Adverse events in British hospitals
Authors: T. V Nguyen
Journal: BMJ (2001)

Analysis of adverse events must result in improvements in careEditor-In his editorial on medical errors Alberti mentions studies of adverse events from Australia and the United States. 1 He then welcomes a paper by Vincent et al 2 : "Finally, we now have some British data from London based on retrospective record reviews" (of 1014 patients in two acute hospitals in London).In 1980 colleagues and I published a detailed audit of adverse events occurring in 2607 inpatients treated by one surgical firm at the Radcliffe Infirmary in 1978. 3 Major, moderate, and minor adverse events in adults and children were recorded prospectively, and we made suggestions (which we hoped would be noted by clinicians and administrators) that might encourage wider adoption of this type of investigation so that clinical care might be improved.In 1990 I wrote an editorial in the BMJ on the findings of the 1989 national confidential enquiry into perioperative deaths (within 30 days of surgery) among children aged under 11. 4 The editorial's concluding sentence was: "If clinical information services are improved . . .then an even more formidable task may lie ahead: the investigation of perioperative morbidity."In 2000, England's chief medical officer suggested that a national system for recording adverse events should be set up. 5 This suggestion has Alberti's support, although he describes it as an enormous undertaking.I hope that we will not have to wait yet another decade before the analysis of data concerning adverse events leads to action being taken to improve care.Prompt action by the Department of Health to provide the resources necessary for this initiative would go some way to compensate for the previous delays.
Feline Uveal Melanomas Induced With Feline Sarcoma Virus: Potential Model of the Human Counterpart&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn3"&gt;3&lt;/xref&gt;
Authors: John A. Shadduck
 5, Daniel M. Albert, Jerry Y. Niederkorn
Journal: JNCI Journal of the National Cancer Institute (1981)

Uveal melanomas were produced by injecting Gardner strain feline fibrosarcoma virus intraocularly into 10- to 15- day-old noninbred kittens. Tumors developed in about 90% of the cats' eyes receiving virus. Progressing tumors (62 eyes of 36 cats) began as small hyperpigmented lesions at the site of injection and grew to fill the anterior chamber by 3–5 months after infection. About 30% of cats with these tumors developed secondary tumors and died. Nonprogressive tumors characterized by flat, pigmented plaques on the iris at the site of injection developed in 25 eyes of 18 cats. These lesions did not enlarge except in proportion to the growth of the eye. Tumors were composed of pigmented spindle cells, pigmented epithelioid cells, and nonpigmented spindle cells. The cells could be grown for 5–8 passages in vitro. One culture assumed a transformed morphology and grew in noninbred athymic nu/nu mice. The lesions resembled human spindle cell melanomas.
Massive Acute Pulmonary Embolism
Authors: Nanette K. Wenger
Journal: JAMA (1972)

Signs, symptoms, and laboratory data to support the diagnosis of pulmonary embolism are often deceivingly nonspecific. Ninety patients with documented massive pulmonary embolism had few clinical and laboratory findings traditionally described for pulmonary infarction; only 62% had pleuritic chest pain, 27% had hemoptysis, and 17% had a pleural rub. Fifteen percent had a normal x-ray film of the chest, and only 31% had an electrocardiogram typical of acute cor pulmonale. Fifty-eight percent presented without phlebitis. Dyspnea was the most frequent symptom (80%), and most patients had a well-defined condition, predisposing them to pulmonary embolism.
Leads from the MMWR. Aldicarb food poisoning from contaminated melons--California
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Is Medical Diagnosis a General Computer Problem?
Authors: Theodor D. Sterling
Journal: JAMA (1966)

An excellent and concise summary of the rationale for the intermittent concern some physicians have shown about the possible assistance computers may render the diagnostician was recently advanced by Bruce and Yarnall.<sup>1</sup>Whenever he makes a decision on diagnosis, prognosis, or choice of therapy, the physician faces the possibility of being "wrong." Can the computer help minimize the number and seriousness of such errors? Allegations and claims concerning the ability of computers to function as diagnosticians have accompanied the growth of medical computer applications from the beginning. Sufficient experience with computers has accumulated by now so that we can examine the possibility of computer-based diagnosis more critically. Such a careful evaluation is also called for because many astute and thoughtful physicians have been repelled by exaggerated and misinformed claims of what the computer can and cannot do. These exaggerations detract from the real service computers can eventually and indeed
Abuse of Pentazocine
Authors: William R. Halliday
Journal: JAMA (1973)

<h3>To the Editor.—</h3> The medical staff of this large workmen's compensation agency is increasingly concerned about addictive or habituating properties and abuses of pentazocine. Our department has assumed financial responsibility for several month-long hospitalizations for withdrawal from iatrogenic habituation or addiction to injectable pentazocine lactate (Talwin) in "industrial low-back problems." In some of the cases, resistance to withdrawal from pentazocine lactate appears as bitter as to any other addicting agent. Two current cases demonstrate especially alarming patterns of abuse. <h3>Report of Cases.—Case 1.—</h3> A 38-year-old man reported complaints of acute dyspnea, tachypnea, and numbness and tingling of the extremities of several hours' duration, and also chronic back pain with a history of five back surgeries allegedly due to a 1964 industrial back injury. The emergency room report noted that the antecubital veins were thrombosed bilaterally. Patchy cellulitis was present, and "hundreds of needle puncture sites." The patient stated
The Management of Hypertension
Authors: George N. Aagaard
Journal: JAMA (1973)

This report on the management of hypertension is presented as a part of the Drug Spotlight Program. We will attempt to answer two questions: "Who should be treated for elevated blood pressure?" and "How should hypertension be treated?" The diagnosis of specific causes of elevated blood pressure and the detailed pharmacology of antihypertensive drugs will not be considered. Life insurance data and epidemiologic studies show that increases of either systolic or diastolic blood pressure are associated with increased morbidity and mortality from cardiovascular, cerebrovascular, and renal disease. The Veterans Administration Cooperative Study<sup>1-3</sup>showed that drug therapy will drastically reduce complications and deaths. Unfortunately, most of the persons with hypertension in the United States are unaware of their hypertension, or are untreated. A recent study<sup>4</sup>showed that 58.9% of hypertensives found in a survey were previously undetected. As many as 16.4% of hypertensives had had diagnoses on earlier examinations,
Ethics Committees and Decisions to Limit Care
Authors: Troyen A. Brennan
Journal: JAMA (1988)

Decisions to limit care for terminally ill patients present a number of ethical and legal issues. For the past 13 years, the Optimum Care Committee (OCC) of the Massachusetts General Hospital, Boston, has provided advice for physicians faced with such issues. I have reviewed the experience of the committee with the 73 cases on which it provided consultation from 1974 through 1986. In addition, I have compared these cases with those of all 113 patients at the Massachusetts General Hospital who were accorded do-not-resuscitate status without OCC input during a three-month period and found that the two groups differed significantly on a number of clinical variables. I have also found that the OCC cases fall into six categories, each of which presents different ethical and legal issues. In addition, the use of the OCC within the hospital is increasing especially with regard to certain categories of cases. The committee has dealt with controversial issues in a consistent and ethically forthright manner, but legal and moral questions remain. More discussion of the role of ethics committees in withdrawal-of-care cases is needed. (<i>JAMA</i>1988;260:803-807)
Is There A Doctor Shortage?
Authors: James K. Cooper
Journal: JAMA (1974)

THE NATIONAL shortage of physicians continues to receive widespread attention. Although many people agree there are locations in need of physicians, it has been difficult to determine satisfactorily the total national need for additional physicians. One often quoted estimate is that of the Federal Bureau of Health Manpower in 1967. They estimated a national shortage of 50,000 physicians.<sup>1</sup>This estimate awakened national concern and spurred Congressional and other action during the last seven years. The estimate is usually accepted without much question of its validity; but, because of its importance, it should be subjected to critical analysis. The estimate was obtained from a series of assumptions (1) The average prepaid group-practice ratio of about 100 physicians to 100,000 population best reflects the current minimum needs of the nation; although the overall US ratio is higher, in 1967 there were 27 states with a physician per 100,000 population ratio below
JOURNAL OF MEDICAL RESEARCH.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal