tbuckley/cabot-search huggingface dataset:
Functional profiling of allergen-specific effector CD4+ T cells in mouse models of food allergy
Authors: David Menchén-Martínez, Leticia Pérez-Rodríguez, Rosina López-Fandiño, Elena Molina
Journal: Journal of Allergy and Clinical Immunology (2023)

Allergen-specific T cells have demonstrated to be crucial in the course of food allergy. We hypothesized that the identification of allergen-specific T cells by using activation markers may allow their monitoring at effector sites. The aim of this study is to identify the functional profile of allergen-specific T cells a murine model of food allergy. C57BL/6J mice were orally sensitized to peanut using cholera toxin as an adjuvant. Cells from different organs were isolated, rested overnight and then restimulated in vitro with peanut for 6h. The upregulation of activation markers (CD154, CD69, and CD137) analyzed by flow cytometry was used to identify allergen-specific T cells. The phenotypical and functional profile was characterized by the expression of IL-4, IFN, IL-10, CD103, and CCR9. Peanut-specific T cells were identified as CD3+CD4+CD44+CD154+ and they were significantly increased in all the organs studied. Spleen CD154+ T cells were significantly correlated with peanut-specific IgG1 levels (Pearson r=0,862). Peanut-specific CD154+ T cells showed a remarkable Th2 phenotype as shown by their increased expression of IL-4. Our results revealed that peanut-specific T cells migrate from the amina propria (0.450 ± 0.070% of CD154+ in memory T cells) to distal axillary lymph nodes (0.085 ± 0,025% of CD154+ in memory T cells) based on their increased expression of gut homing marker CCR9 (56.230 ± 9.812% of CCR9+ cells in memory CD154+ T cells). Our results conclude that allergen-specific effector T cells migrate from intestinal mucosa to secondary lymphoid organs, exerting their pathogenic effect by the secretion of IL-4.
Allergic Bronchopulmonary Aspergillosis in Patients with Dominant Negative IL6ST
Authors: Jennifer Roper, Sebastian Ochoa, Anahita Agharahimi, Justina Pfister, Magdalena Walkiewicz, Amanda Urban, Rajarshi Ghosh, Michail Lionakis, Lisa Kohn, Kenneth Olivier, Alexandra Freeman
Journal: Journal of Allergy and Clinical Immunology (2023)
Enhanced Medical Support for Primary Immunodeficiency Disorders (PIDD): A Patient-guided Intervention to Ensure Patient Engagement During a Global Pandemic and Beyond
Authors: Kathleen Sullivan, Pam McFadden, Steve Folstein, Monica Augustyniak, John Boyle, Victoria Dimitriades, Carla Duff, Katja Fort-Rhoden, Jennifer W. Leiding, Kenneth Paris, Nicholas Rider, Christopher Scalchunes, Marry Elizabeth Younger, Patrice Lazure, Ginny Jacobs
Journal: Journal of Allergy and Clinical Immunology (2023)
T-Cell Clonality, Functional Changes, and Clinical Response after Dupilumab in Atopic Dermatitis and Asthma Patients
Authors: Michelle Dilley, Lauren Loop, Ben Croker, Seema Aceves, Nathan Lewis, Yanfang Zhu, Jamie Lee, Isaac Shamie, Austin Chiang, Anoushka Tambay, Bob Geng
Journal: Journal of Allergy and Clinical Immunology (2023)
Towards a translational computational model of allergen challenge in mild asthma to support clinical development of an intranasal administration of a bacterial lysate
Authors: Simon Arsène, Igor Faddeenkov, Théo Galland, Cristhyne Leon, Lorenz Lehr, Caterina Sansone, Anne Vaslin-Chessex, Christian Pasquali, Alexander Kulesza
Journal: Journal of Allergy and Clinical Immunology (2023)
Photoelectrochemical Oxidation Assisted Indoor Air Purification Mitigates Aerosolized Cat Dander Induced Allergic Asthma in a Murine Model
Authors: Jaspreet Dhau, Dinesh Devadoss, Kerri Surbaugh, Marco Manevski, Arriane Chung, Francisco de Leon, Hitendra Chand
Journal: Journal of Allergy and Clinical Immunology (2023)
Asthma Management Among Children With Food Allergy in the FORWARD Study During COVID-19
Authors: Neil Thivalapill, Sai Nimmagadda, Lucy Bilaver, Jialing Jiang, Johnathan Choi, Eirene Fithian, Khalid Ibrahim, Jennifer Long, Pamela Newmark, Christopher Warren, Mark Wlodarski, Annika Chura, Megan Muccigrosso, Amal Assa'ad, Aame Betty Andy-Nweye, Susan Fox, Mary Tobin, Mahboobeh Mahdavinia, Linda Herbert, Izeris Ortiz-Rodriguez, Hemant Sharma, Perry Catlin, Andrea Pappalardo, Ruchi Gupta
Journal: Journal of Allergy and Clinical Immunology (2023)
Dupilumab Reduces Exacerbations And Improves Lung Function In Children (6–11 Years) With Moderate-To-Severe Asthma And High Eosinophils
Authors: Daniel Jackson, Eckard Hamelmann, Graham Roberts, Leonard Bacharier, Arman Altincatal, Rebecca Gall, Olivier Ledanois, Juby Jacob-Nara, Amr Radwan, Paul Rowe, Yamo Deniz
Journal: Journal of Allergy and Clinical Immunology (2023)
In silico exploration of atopic dermatitis phenotypes for clinical trial design optimization
Authors: Natacha Go, Simon Arsène, Loic Etheve, Igor Faddeenkov, Théo Galland, Diane Lefaudeux, Shiny Martis, Claudio Monteiro, Yishu Wang, Jean-Pierre Boissel, Aude Chevalier, Lorenz Lehr, Christian Pasquali, Alexander Kulesza
Journal: Journal of Allergy and Clinical Immunology (2023)
Tezepelumab Reduces Exacerbations Across All Seasons In Patients With Severe, Uncontrolled Asthma With Seasonal Allergy: Results From The Phase 3 NAVIGATOR Study
Authors: Jonathan Corren, Andrew Lindsley, Joseph Spahn, Bill Cook, Janet Griffiths, Nicole Martin, Gene Colice, Ian Pavord
Journal: Journal of Allergy and Clinical Immunology (2023)
Evaluation of a Panel of Cellular Biomarkers for Immune Dysregulation in Inborn Errors of Immunity
Authors: Priya Patel, Boglarka Ujhazi, Melis Yilmaz, David Potts, Maryssa Ellison, Cristina Meehan, Sumai Gordon, Rachel Cruz, Irmel Ayala, Don Eslin, Erin Cockrell, Felipe Rico, Jennifer Mayer, Mei Sing-Ong, Anna Meyer, Charles Hauk, Joseph Dasso, Emma Westermann-Clark, Panida Sriaroon, Kriztian Csomos, Jolan Walter
Journal: Journal of Allergy and Clinical Immunology (2023)
Single-cell RNA-Seq identifies precise tolerogenic cellular and molecular pathways induced by depigmented-polymerized grass pollen allergen extract
Authors: Janice Layhadi, Raquel Moya Lobo, Tan Tiak Ju, Madison Burki, Hjh Hanisah Hj Awg Sharif Hj Awg Sharif, Rebecca Parkin, Gemma Vila-Nadal, Oleksandra Fedina, Stephen Durham, Jeronimo Carnes, Mohamed Shamji
Journal: Journal of Allergy and Clinical Immunology (2023)
Reporting of Adverse Drug Reactions with Parenteral Drugs for the On-Demand Treatment of Hereditary Angioedema Attacks – Analysis of the FAERS Database 2009 to 2022
Authors: Raffi Tachdjian, Sinisa Savic, Moshe Fridman, Joao Frade, Paul Audhya, Marie Fasehun
Journal: Journal of Allergy and Clinical Immunology (2023)
Patient Perspectives On Early Use Of On-demand Treatment For Hereditary Angioedema (HAE) Attacks to Reduce Severity and Duration.
Authors: Cristine Radojicic, Michael Manning, Mar Guilarte, Markus Heckmann, Sally van Kooten, Sherry Danese, Ledia Goga
Journal: Journal of Allergy and Clinical Immunology (2023)

Hereditary Angioedema (HAE) attacks are characterized by recurrent, unpredictable episodes of swelling throughout the body. On-demand treatment is effective but may be impacted by time to administration. This survey investigated perspectives of people living with HAE regarding on-demand treatment of HAE attacks and outcomes. People living with HAE were invited to participate in one of four 2-hour focus groups (November 2021 and March 2022). Inclusion criteria enriched for patients utilizing on-demand treatment only, versus those experiencing breakthrough attacks while on prophylactic treatment. Participants included 32 patients; 23 (72%) US/9 (28%) international, mean age 33yrs (15-72yrs), reporting a mean of 33 attacks (median 18) annually. HAE therapies included on-demand only (68%) or prophylactic treatment with on-demand treatment for breakthrough attacks (32%). Patients reported not carrying their on-demand medication with them 50% of the time. Delayed treatment was associated with longer duration of attacks (77%) ranging from hours (29%) to 1 week (14%). 80% reported that the longer treatment was delayed, the more painful and severe the attacks; 82% reported faster recovery using on-demand treatment at earliest recognition of an attack. Shorter recovery time allowed 97% to return to planned activities, 'work' for 42% of adults (19+yrs), 'school' for 67% of adolescents (15-18yrs). Quicker recovery was noted as being 'important' or 'very important' by 90%. Survey revealed that patients often do not carry their HAE medication and highlighted negative impacts of delaying HAE attack treatment. Further exploration of why patients delay treatment will inform a patient-centered approach to HAE attack management.
Dupilumab improves type 2 comorbidity outcomes in patients with eosinophilic esophagitis and comorbid disease at baseline: from Parts A and B of LIBERTY-EoE-TREET
Authors: Jonathan Spergel, Lawrence Sher, Sandy Durrani, Evan Dellon, Marc Rothenberg, Xian Sun, Bethany Beazley, Kiran Patel, Arsalan Shabbir
Journal: Journal of Allergy and Clinical Immunology (2023)
Berotralstat Improved Quality of Life through 96 Weeks Across Multiple Subgroups of Patients with Hereditary Angioedema
Authors: Daniel Soteres, William Lumry, Markus Magerl, Remi Gagnon, Bhavisha Desai, Dianne Tomita, Douglas Johnston, Marcus Maurer
Journal: Journal of Allergy and Clinical Immunology (2023)
Nasal airway microRNA profiling of infants with severe bronchiolitis and risk of childhood asthma: A multicenter prospective study
Authors: Zhaozhong Zhu, Robert Freishtat, Brennan Harmon, Andrea Hahn, Stephen Teach, Marcos Pérez-Losada, Kohei Hasegawa, Carlos Camargo
Journal: Journal of Allergy and Clinical Immunology (2023)
Efficacy of lanadelumab at fixed and modified dosing regimens in patients aged 2 to &lt;12 years old with hereditary angioedema (HAE) in the phase 3, open-label, multicenter SPRING Study
Authors: William Lumry, Jonathan Bernstein, Raffi Tachdjian, H. James Wedner, William Yang, Marcus Maurer, Inmaculada Martinez-Saguer, Henriette Farkas, Christina Nurse, Ming Yu
Journal: Journal of Allergy and Clinical Immunology (2023)
Combinations of Probiotic Bacteria (Lactobacillus helveticus, Bifidobacterium longum, Lactobacillus rhamnosus, Sacchammyces boulardii) Restores the Skin Microbiome in Atopic Dermatitis
Authors: Yuriy Bisyuk, Oleksandr Litus, Nadiya Boyko, Viktor Litus, Bohdan Lytvynenko, Oleksandra Pallag, Liudmyla Konovalenko, Lawrence DuBuske
Journal: Journal of Allergy and Clinical Immunology (2023)
Systemic Reactions in Infants and Toddlers: A Prospective Study of Oral Food Challenge Outcomes
Authors: Lourdes Ramirez, Ian Roy, Isha Taneja, Samantha Yap, Jose Mendez-Reyes, Mharlove Andre, Arielle Hazi, Cynthia Esteban, Zoe Ongaro, Lydia Pan, Wayne Shreffler, Michael Pistiner
Journal: Journal of Allergy and Clinical Immunology (2023)
Longitudinal assessment of Allergic Outcomes and Atopic Dermatitis Phenotypes in The Children's Respiratory and Environmental Workgroup (CREW) Birth Cohort Consortium
Authors: Amy Eapen, Alexandra Sitarik, Jocelyn Biagini, Daniel Jackson, Christine Joseph, Haejin Kim, Lisa Martin, Katherine Rivera-Spoljaric, Eric Schauberger, Ganesa Wegienka, James Gern, Anne Marie Singh
Journal: Journal of Allergy and Clinical Immunology (2023)
WOTNUT: Nut Allergic Children and Their Parents Are No Better at Identifying Nuts Than Controls Without Nut Allergy
Authors: Fionnuala Heraghty, Niamh Flynn, Sadhbh Hurley, Mairead Sheehan, Fiona Wilson, Maeve Kelleher, Aideen Byrne, Jonathan Hourihane
Journal: Journal of Allergy and Clinical Immunology (2023)
The Value of IL-25, IL-33, and TSLP in Nasal Secretions as a Biomarker of Severity of Allergic Rhinitis in Children
Authors: Toshiko Itazawa, Eiji Morita, Takeshi Koga, Keisuke Okada, Takahiro Shimizu, Yutaka Ueda
Journal: Journal of Allergy and Clinical Immunology (2023)
Oral Corticosteroid Burden and Healthcare Resource Utilization (HCRU) in Patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) Undergoing Functional Endoscopic Sinonasal Surgery (FESS): A Real-World Retrospective Cohort Study
Authors: Danielle Isaman, Asif Khan, Stella Lee, Anju Peters, Peter Hwang, Sietze Reitsma, Natalia Petruski-Ivleva, Scott Nash, Juby Jacob-Nara
Journal: Journal of Allergy and Clinical Immunology (2023)
Disease Burden and Physician-Reported Outcomes in Pediatric Patients With Hereditary Angioedema: Data From A Real-World Study
Authors: Raffi Tachdjian, Daniel Soteres, John Anderson, Jennifer Mellor, Hannah Connolly, Kieran Wynne-Cattanach, Lucy Earl, Bob Schultz, Salomé Juethner
Journal: Journal of Allergy and Clinical Immunology (2023)
Allergenicity of Egg White Powder Compared to Baked Egg White Powder
Authors: Meredith Schuldt, Kevin White, Robert Gomez
Journal: Journal of Allergy and Clinical Immunology (2023)

There are several new products with baked egg powder marketed for possible prevention of food allergies. Previous studies have shown that standard egg white powder is equivalent to raw egg whites in allergenicity. It is known that heating destroys many conformational epitopes and reduces allergenicity in eggs, thus our aim was to compare the binding of serum IgE from egg-allergic patients to different formulations of egg white powders to evaluate the possible allergenicity of these baked egg products. Egg proteins from regular egg white powder, baked egg white, and baked egg white with tapioca were separated by SDS-PAGE, transferred onto nitrocellulose membrane, and incubated with pooled sera from egg-allergic patients. There were differences in protein signatures found in the SDS-page. Regular egg white powder showed strongly staining bands consistent with all major egg allergens. In contrast, protein bands were apparent corresponding to Gal d 1 in baked egg white powder but were only faintly present in baked egg white powder with tapioca. In the baked egg white powder with tapioca a prominent Gal d 2 pattern was present that was absent in the baked egg powder. The IgE immunoblot demonstrated three protein bands for the regular egg white powder, however there was no IgE binding demonstrated for either baked egg white formulations. This study showed differences in egg protein content between two different baked egg formulations. There was no IgE binding to corresponding protein bands for ovomucoid or ovalbumin in immunoblots of baked egg white powders.
Efficacy and safety of low-dose cyclosporine relative to immunomodulatory drugs used in atopic dermatitis: A systematic review and meta-analysis
Authors: Kyunhoon Kim, Mina Kim, EunHee Rhee, Mi-Hee Lee, Hyeon-Jong Yang, Suyeon Park, Hwan Soo Kim
Journal: Journal of Allergy and Clinical Immunology (2023)
Transcriptomic analysis of airway epithelial cells identifies an altered expression profile of T2 and non-T2 genes in chronic rhinosinusitis with nasal polyposis
Authors: George Huang, Nils Hallen, Jonathan Hacker, Alanna McGill, Tessa Ryan, Regan Bergmark, Neil Bhattacharyya, Stella Lee, Alice Maxfield, Rachel Roditi, Kathleen Buchheit, Tanya Laidlaw, Joshua Boyce, Maria Gutierrez-Arcelus, Nora Barrett
Journal: Journal of Allergy and Clinical Immunology (2023)
An Agonistic Monoclonal Antibody Against Siglec-6 Broadly Inhibits Mast Cell Activation in Transgenic Mice
Authors: Zachary Benet, Thuy Luu, Emily Brock, Robert Sanchez, Lisa McEwen, Krysta Coyle, Katherine Chang, John Leung, Julia Schanin, Bradford Youngblood
Journal: Journal of Allergy and Clinical Immunology (2023)
Efficacy And Safety Of Bradykinin B2 Receptor Inhibition With Oral PHVS416 In Treating Hereditary Angioedema Attacks: Results Of RAPIDe-1 Phase 2 Trial
Authors: Marcus Maurer, John Anderson, Emel Aygören-Pürsün, Laurence Bouillet, María Luisa Baeza, Hugo Chapdelaine, Danny Cohn, Aurélie Du-Thanh, Olivier Fain, Henriette Farkas, Jens Greve, Mar Guilarte, David Hagin, Roman Hakl, Joshua Jacobs, Aharon Kessell, Sorena Kiani-Alikhan, Pavlína Králíčková, Huamin Li, Ramon Lleonart Bellfill, Markus Magerl, Michael Manning, Avner Reshef, Bruce Ritchie, Giuseppe Spadaro, Maria Staevska, Petra Staubach, Marcin Stobiecki, Gordon Sussman, Michael Tarzi, Anna Valerieva, William Yang, Marie-Helene Jouvin, Rafael Crabbé, Simone van Leeuwen, Huaihou Chen, Li Zhu, Jochen Knolle, Anne Lesage, Peng Lu, Marc Riedl
Journal: Journal of Allergy and Clinical Immunology (2023)
Infants with loss of function filaggrin mutations show augmented response to early life, short term skin barrier protection compared to filaggrin wild type infants; results from the STOP-AD trial.
Authors: Jonathan Hourihane, Claudio Nico, Dhanis Lad, Gerwin Puppels, Carol Ni Chaoimh, Colin Wong, John Common, Peter Caspers, Alan Irvine
Journal: Journal of Allergy and Clinical Immunology (2023)
Initial Results from a Phase 1 Single Ascending Dose Clinical Trial of STAR-0215, an Investigational Long-Acting Monoclonal Antibody Plasma Kallikrein Inhibitor for Hereditary Angioedema (HAE), in Healthy Subjects Followed for at Least 3 Months
Authors: Christopher Morabito, Chris Stevens, Jou-Ku Chung, Rafif Dagher, Pradeep Bista, Kristine Bernard, Pamela Gustafson, Michele Gunsior, Andy Nichols
Journal: Journal of Allergy and Clinical Immunology (2023)
Dupilumab inhibits vascular leakage of blood proteins into atopic dermatitis skin
Authors: Donald Leung, Robert Bissonnette, Evgeny Berdyshev, Simion Kreimer, Taras Lyubchenko, Shantanu Bafna, Brittany Richers, Shannon Garcia, Marco Ramirez-Gama, Clifton Hall, Olivia Xiao, Patricia Taylor, Mark Boguniewicz, Noah Levit, Inoncent Agueusop, Annie Zhang, Elena Goleva
Journal: Journal of Allergy and Clinical Immunology (2023)
Real-World Effectiveness of Lanadelumab in Patients With Normal C1-Inhibitor Hereditary Angioedema: A Multicenter Chart Review
Authors: Daniel Soteres, Jonathan Bernstein, Henry Kanarek, Drew Mutschelknaus, Todor Totev, Jingyi Chen, Fan Mu, Mary Lynn Cala, Bob Schultz, Salomé Juethner, Lisa Young
Journal: Journal of Allergy and Clinical Immunology (2023)
Mepolizumab Alters Regulation of Airway Type-2 Inflammation in Urban Children with Asthma by Disrupting Eosinophil Gene Expression but Enhancing Mast Cell and Epithelial Pathways
Authors: Courtney Gaberino, R. Max Segnitz, Madison Cox, Leonard Bacharier, Agustin Calatroni, Michelle Gill, Jeffrey Stokes, Andrew Liu, Robyn Cohen, Melanie Makhija, Gurjit Khurana Hershey, George O'Connor, Edward Zoratti, Stephen Teach, Meyer Kattan, Patrice Becker, Alkis Togias, William Busse, Daniel Jackson, Matthew Altman
Journal: Journal of Allergy and Clinical Immunology (2023)
Comparison of Hereditary Angioedema Among Patients of Different Races and Ethnicities in the United States: Data From a Real-World Study
Authors: John Anderson, Timothy Craig, Jennifer Mellor, Lucy Earl, Hannah Connolly, Kieran Wynne-Cattanach, Krystal Sing, Salome Juethner, Bob Schultz
Journal: Journal of Allergy and Clinical Immunology (2023)
Pharmacokinetics (PK), Pharmacodynamics (PD), and Exposure-Response (E-R) Analyses Confirm the Effectiveness of Lanadelumab in Patients 2 to &lt;12 Years Old With Hereditary Angioedema (HAE)
Authors: Mariam Ahmed, Yi Wang, Ming Yu, Jean-Francois Marier, Indranil Bhattacharya
Journal: Journal of Allergy and Clinical Immunology (2023)
Generation of Functionally Competent Eosinophils and Eosinophil Precursors Using an Induced Pluripotent Stem Cell Model
Authors: Gregory Constantine, David Espinoza, Elizabeth Swain, Xiaoping Sun, Irina Maric, Gila Idelman, Patricia Fulkerson, Michelle Makiya, Calman Prussin, Amy Klion
Journal: Journal of Allergy and Clinical Immunology (2023)
Progressive Accumulation of Hyperinflammatory NKG2Dlow NK Cells in Early Life Defines a Novel Endotype of Severe Atopic Dermatitis
Authors: David Ohayon, Stanley DeVore, Wan-Chi Chang, Durga Durga Krishnamurthy, Harsha Seelamneni, Brittany Grashel, None daniel spagna, Jocelyn Biagini, Lisa Martin, Stephen Waggoner, Gurjit Khurana Hershey
Journal: Journal of Allergy and Clinical Immunology (2023)
The impacts of ambient air pollution exposure during pregnancy on maternal and neonatal inflammatory biomarkers
Authors: Ji Won Ha, Juan Aguilera, Youn Soo Jung, Stuart Cansdale, Fred Lurmann, Liza Lutzker, Katharine Hammond, John Balmes, Elizabeth Noth, Ellen Eisen, Nima Aghaeepour, Gary Shaw, Anne Waldrop, Purvesh Khatri, P.J. Utz, Yael Rosenburg-Hasson, Holden Maecker, Trevor Burt, Kari Nadeau, Mary Prunicki
Journal: Journal of Allergy and Clinical Immunology (2023)
MOD000001, a Novel Highly Selective and Orally Available KIT Inhibitor, Suppresses Passive Cutaneous Anaphylactic (PCA) Reaction and Food Allergy in Mice
Authors: Atsuhito Nakao, Takeo Urakami, Yuki Nakamura, Kayoko Ishimaru, Vuong Tran, Taisuke Takahashi, Takafumi Shimizu, William Sinko, Venkateshwar Gummadi, Amit Dhudashiya, Ravikrishna Babu, Yoh Terada
Journal: Journal of Allergy and Clinical Immunology (2023)

Mast cells (MCs) play a central role in the development of IgE-mediated allergic diseases, including allergic urticaria and food allergy. SCF/KIT signaling is essential for the differentiation, proliferation, survival, and activation of MCs. Thus, highly selective KIT inhibitors would have therapeutic potential for IgE/mast cell-mediated allergic diseases through homeostatic regulation of mast cells while minimizing side effects caused by the inhibition of non-KIT kinases, such as PDGFR and VEGFR. The effects of MOD000001, a novel highly selective and orally available KIT inhibitor, were evaluated in 2 mouse models: passive cutaneous anaphylaxis (PCA), a classical model of IgE/mast cell-mediated skin allergic reaction, and ovalbumin (OVA)-induced food allergy (FA). KIT inhibition on human MCs was evaluated using MCs differentiated in vitro from CD34+ hematopoietic stem cells. Orally administered MOD000001 significantly inhibited the PCA reaction and OVA-induced diarrhea in the FA model. MOD000001 reduced the numbers of mast cells in the skin and gut in the model mice. In addition, MOD000001 downregulated FceRI expression on peritoneal mast cells. MOD000001 inhibited proliferation and differentiation of primary cultured human MCs. MOD000001 suppresses both cutaneous and gastrointestinal allergic reactions in mice, and is associated with the reduction of local tissue-resident mast cell numbers and FceRI expression levels on mast cells. Thus, the selective KIT inhibitor MOD000001 may benefit patients suffering from IgE-mediated allergic diseases by affecting homeostatic conditions of mast cells.
Phase 1 Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Garadacimab (CSL312) in Healthy Japanese and Caucasian Adults
Authors: Fiona Glassman, Summer Goodson, Alex Bica, Anthony Roberts, Hideto Akama, Yumiko Asami, Meena Jain, Milin Acharya
Journal: Journal of Allergy and Clinical Immunology (2023)
Dupilumab Treatment Reduces Total IgE Levels in Patients 6 Months and Older with Moderate-to-Severe Atopic Dermatitis
Authors: Elaine Siegfried, Michael Cork, Mark Boguniewicz, Mette Deleuran, Eric Simpson, Zhen Chen, Drew Clearfield, Parul Shah, Ainara Rodriguez-Marco
Journal: Journal of Allergy and Clinical Immunology (2023)
Efficacy of Lebrikizumab in Patients With Atopic Dermatitis and Atopic Comorbidities: Pooled Results From Two Phase 3 Monotherapy Randomized, Double-Blind, Placebo-Controlled 16-Week Studies (ADvocate1 and ADvocate2)
Authors: Ellen Sher, Mark Boguniewicz, Alexandra Golant, Jinglin Zhong, Amber Reck Atwater, Zach Dawson, Kimberly Siu, Marjolein de Bruin-Weller, Jose-Manuel Carrascosa, Jacob Thyssen
Journal: Journal of Allergy and Clinical Immunology (2023)
Characteristics of Patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) Who Did or Did Not Undergo Functional Endoscopic Sinus Surgery (FESS) in a US Real-World Retrospective Cohort Study
Authors: Asif Khan, Danielle Isaman, Stella Lee, Anju Peters, Peter Hwang, Sietze Reitsma, Natalia Petruski-Ivleva, Scott Nash, Juby Jacob-Nara
Journal: Journal of Allergy and Clinical Immunology (2023)