tbuckley/cabot-search huggingface dataset:
Eyebrows, Plus or Minus
Authors: Frederick A. J. Kingery
Journal: JAMA (1966)

Loss of eyebrow hair (madarosis) is one of those signs which delights the elegant practitioner of the art of physical diagnosis, for at a glance he can recognize a number of otherwise unrelated diseases. Hypertrichosis of the eyebrows is also a sign which demands explanation when not on the basis of heredity. On this page are a collection of illustrative examples in which changes in the normal pattern of eyebrow growth give a major clue to the underlying problem.
Health Center Impact on Hospital Utilization
Authors: Gordon T. Moore
Journal: JAMA (1974)

Hospital utilization was studied one year before and again two years after the opening of a neighborhood health center, to determine the effect of the health center on hospital use by residents of the community. Per capita admissions to the hospital affiliated with the health center increased by 56.1%. Study of a matched subsample of the community demonstrated a shift of use, as measured by hospital expenditures, to the affiliated hospital, with a slight decrease in the use of other hospitals. Hospital expenditures by this subsample increased substantially between the two years, suggesting an overall increase in hospital use by the community's residents. (<i>JAMA</i>228:332-333, 1974)
Don't Ignore Patients' Threats, Psychiatrists Told
Authors: Lynne Lamberg
Journal: JAMA (1996)

"I HATE YOU, I hate you, I hate you," a patient shrieks into a psychiatry resident's answering machine. A later message is more ominous: "I'm going to kill you." More chilling still: The resident's program director did not take these threats seriously, said forensic psychiatrist John Lion, MD, who played tapes of the calls at a workshop on the management of threats on the lives of clinicians at this year's annual meeting of the American Psychiatric Association (APA). <h3>Attacks Not Uncommon</h3> Physicians commonly discount risks of attacks by patients, said Lion, clinical professor of psychiatry at University of Maryland School of Medicine, Baltimore, adding, "They don't want to think the places they work may be dangerous." But at least 1 US physician is killed by a patient nearly every year, Lion said. About half of the 30 workshop attendees reported having been threatened, physically attacked, or stalked; some even reported
Medical Education on the SS Hope
Authors: Rufus C. Morrow
Journal: JAMA (1970)

One of the principal functions of the SS Hope is medical teaching at all levels of physician development. In the senior group this takes the form of a mature international exchange to the mutual benefit of both visiting and host participants. At less developed levels, it becomes not so much a matter of imparting information as the demonstration of attitudes, habits, and principles basic to good all-round patient care and community concern. Advanced techniques are demonstrated as ultimate goals for development, but practical application of medical knowledge to the socioeconomic conditions of the host country is the true primary objective.
Improving the debate on cannabis
Authors: W. Notcutt
Journal: BMJ (2000)

# Let's find out whether cannabis has therapeutic value {#article-title-2} EDITOR—In discussions of the use of cannabis one of the biggest problems over the past few years has been the difficulty in separating the debate on the recreational use from that on the therapeutic use. The article by Strang et al also mixes the two issues.1 In all my years of working in pain relief I cannot remember the equivalent mix-up taking place over cocaine, morphine, heroin, etc. Although some matters occasionally overlap, the two main elements of the cannabis debate must remain in separate arenas. Only then can we educate politicians and the public about the facts and the real issues. Meanwhile, let's get on and find out whether cannabis has significant and valuable therapeutic potential. This agent has been used medicinally for 5000 years and we still don't know whether it is therapeutically effective. 1. 1.↵1. Strang J, 2. Witton J, 3. Hall W . Improving the quality of the cannabis debate: defining the different domains. BMJ 2000; 320: 108–110. (8 January.) [OpenUrl][1][FREE Full Text][2] # Consider public welfare, not just public health {#article-title-4} EDITOR—Strang et al raise a number of salient issues in the debate over whether cannabis should be legalised.1 However, the eight “domains of the cannabis debate” identified are centred exclusively on a public health conception of the relevant policy issues. Although this is understandable given the audience that the authors are addressing, they fail to consider more fundamental issues of what the public policy objectives should be when considering the recreational use of cannabis. Their discussion reflects the fact that the medical profession has a natural tendency to judge the public … [1]: {openurl}?query=rft.jtitle%253DBMJ%26rft.stitle%253DBMJ%26rft.issn%253D0007-1447%26rft.aulast%253DStrang%26rft.auinit1%253DJ.%26rft.volume%253D320%26rft.issue%253D7227%26rft.spage%253D108%26rft.epage%253D110%26rft.atitle%253DImproving%2Bthe%2Bquality%2Bof%2Bthe%2Bcannabis%2Bdebate%253A%2Bdefining%2Bthe%2Bdifferent%2Bdomains%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fbmj.320.7227.108%26rft_id%253Dinfo%253Apmid%252F10625271%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=FULL&journalCode=bmj&resid=320/7227/108&atom=%2Fbmj%2F320%2F7250%2F1671.atom
Cancer Mortality Among Farmers
Journal: JNCI Journal of the National Cancer Institute (1984)

Journal Article Cancer Mortality Among Farmers Get access Don P. Buesching, M.A., Don P. Buesching, M.A. University of Illinois College of Medicine at Rockford1601 Parkview Avenue Rockford, Illinois 61107 Search for other works by this author on: Oxford Academic PubMed Google Scholar Loyd Wollstadt, M.D. Loyd Wollstadt, M.D. University of Illinois College of Medicine at Rockford1601 Parkview Avenue Rockford, Illinois 61107 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 72, Issue 3, March 1984, Page 503, https://doi.org/10.1093/jnci/72.3.503 Published: 01 March 1984
The Origin and Evolution of the Human Dentition.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Malpractice Experience of Physicians
Authors: Frank A. Sloan
Journal: JAMA (1989)

This study uses a large malpractice database from Florida to assess the concentration of losses among physicians, predictability of claims experience, characteristics of physicians with favorable vs unfavorable experience, and effects of claims experience on physicians' practice decisions and on actions taken by the state's licensing board. Most payments by insurers involved a comparatively small number of physicians. Physicians with relatively prestigious credentials had no better, and on some indicators, worse claims experience. If anything, physicians with adverse claims experience were less likely to make subsequent changes in their practice, such as quitting practice or moving to another state. Physicians with very poor claims histories were more likely to have complaints filed against them with the Florida licensing board, but the sanctions against physicians with either poor or excellent histories were not severe. Physicians with adverse claims experience from incidents that arose between 1975 and 1980 had appreciably worse claims experience from incidents that arose during 1981 to 1983. (<i>JAMA</i>. 1989;262:3291-3297)
New and Nonofficial Remedies
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impaired Delayed Hypersensitivity In Older Individuals
Authors: Alexander A. Fisher
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Tuft (<b>204</b>:1010, 1968), in commenting on the report of Waldorf et al (<b>203</b>:831, 1968) concerning the impairment in skin reactivity of older individuals after the induction of delayed skin test reaction by the applications of patch tests of 2, 4-dinitrochlorobenzene (DNCB), states that the skin reactivity of older individuals is apparently impaired both in relation to immediate-type and to delayed-type skin test reactions. Tuft concludes that such impairment in skin test reaction in the elderly should be remembered in their employment in clinical practice. However, it must be emphasized that the results of the<i>experimental</i>induction of delayed skin test reaction by the application of patch tests of DNCB does not necessarily correlate with the delayed reactions seen in clinical practice. First, while DNCB will sensitize the vast majority of individuals, clinical contactants, in general, sensitize only a small percentage of the population. Second, sensitization
Catching glaucoma
Authors: F. M Chapman, P. S Phelan
Journal: BMJ (1997)

<h3>Abstract</h3> Co-translational folding is a fundamental molecular process that ensures efficient protein biosynthesis and minimizes the wasteful or hazardous formation of misfolded states. However, the complexity of this process makes it extremely challenging to obtain structural characterizations of co-translational folding pathways. Here we contrast observations in translationally-arrested nascent chains with those of a systematic C-terminal truncation strategy. We create a detailed description of chain length-dependent free energy landscapes associated with folding of the FLN5 filamin domain, in isolation and on the ribosome. By using this approach we identify and characterize two folding intermediates, including a partially folded intermediate associated with the isomerization of a conserved proline residue, which, together with measurements of folding kinetics, raises the prospect that neighboring unfolded domains might accumulate during biosynthesis. We develop a simple model to quantify the risk of misfolding in this situation, and show that catalysis of folding by peptidyl-prolyl isomerases is essential to eliminate this hazard.
Effects of Retinoic Acid Versus Dimethyl Sulfoxide on Friend Erythroleukemia Cell Growth. II. Induction of Quiescent, Nonproliferating Cells&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Frank Traganos, Paul J. Higgins, Connie Bueti, Zbigniew Darzynkiewicz, Myron R. Melamed
Journal: JNCI Journal of the National Cancer Institute (1984)

Treatment of Friend erythroleukemia (FL) cells in vitro with 10−7 to 10−7all-trans-retinoic acid (RA) leads to a concentration-dependent accumulation of a subpopulation of quiescent cells. This subpopulation, termed “Q-cells,” contained markedly reduced RNA and protein levels and had a cell cycle distribution with a predominance of cells in G1 phase, which was nearly identical to that found in fully differentiated dimethyl sulfoxide (CAS:67-68-5; methyl sulfoxide)-induced FL cultures. The G1 cells in this RA-induced subpopulation (G1Q cells), though viable, did not enter S-phase, whereas the small percentage of Q-cells with S and G2 DNA content progressed very slowly through the cycle. While the Q-cell population did not contain the differentiation-associated chromatin protein H1°, the cells did manifest a more condensed nuclear chromatin, altered sensitivity to acid denaturation, and reduced accessibility of the DNA in chromatin to acridine orange. The extent of chromatin condensation and the number of free ribosomes versus polysomes in RA-treated FL cells were intermediate between those in untreated and fully differentiated cells, whereas viral budding and the number of nucleoli remained unchanged from those seen in the untreated cell state. The non-Q-cell population in RA-treated cultures, termed “T” (transitional) cells, had an intermediate RNA and protein content and a cell cycle distribution similar to those of control cultures nearing the plateau phase of growth. In the absence of any late markers of differentiation, the Q-cell population was tentatively identified as a unique, quiescent cell population not previously described in the FL cell system.
A Method for Ensuring Anonymity for AIDS Antibody Screening Away From Blood Banks at Alternate Sites
Authors: Tibor J. Greenwalt
Journal: JAMA (1986)

<h3>To the Editor.—</h3> Places other than blood banks must be provided for persons in high-risk groups for acquired immunodeficiency syndrome to have free screening tests for human T-cell lymphotropic virus type III/lymphadenopathy-associated virus antibodies. These places, referred to as "alternate sites," may be Board of Health Clinics where blood samples can be collected and counseling provided. Anonymity is absolutely essential to ensure the successful operation of such alternate sites for acquired immunodeficiency syndrome antibody screening. Only then can the use of alternate sites be expected to safeguard the blood supply. We have, since May 18, 1985, utilized the following scheme. The Hoxworth Blood Center has a bar code label printing device. Alternate sites are supplied with a series of four attached identical bar code labels. When a person requests testing for the presence of antibodies to human T-cell lymphotropic virus type III/lymphadenopathy-associated virus, one label is used for the specimen
Highlights of This Issue
Journal: Clinical Cancer Research (2011)

Suppression of cellular immunity has long been observed in patients with glioblastoma. Sippel and colleagues provide evidence for activation of circulating neutrophils in patients with glioblastoma associated with increased release of the immunosuppressive enzyme Arginase I (ArgI). In vitro targeting of ArgI resulted in restoration of T-cell function in patients with glioblastoma, providing an intriguing new target for clinical intervention designed to restore cellular immune function in this population.Adhesion of circulating tumor cells to the blood vascular endothelium is a pivotal step in metastasis. In this study, Barrow and colleagues revealed that serum levels of several galectin members were greatly increased in colon and breast cancer patients and promoted cancer-endothelial adhesion by interaction with cancer-associated Thomsen-Friedenreich/mucin 1 protein (TF/MUC1). Elevated circulating galectin-2 levels were associated with increased mortality in cancer patients, but this association was suppressed when auto–anti-MUC1 antibodies with specificity for the TF epitope were also present in the circulation. Thus, increased circulation of several galectin members is common in cancer patients and promotes circulating cancer cell metastatic spreading. Targeting the actions of circulating galectins may therefore represent a promising therapeutic approach to reduce metastasis.Accumulating evidence has demonstrated that tumor-initiating cells (T-IC) are resistant to chemotherapy. Zhu and colleagues demonstrated that mir-128 was significantly reduced in breast T-ICs, with the overexpression of its targets Bmi-1 and ABCC5, which regulated the chemotherapeutic resistance. Furthermore, miR-128 reduction in breast cancer tissues was correlated with chemoresistance and poor survival in patients with breast cancer. These findings imply that examination of miR-128 expression is valuable in predicting patient survival and therapeutic response in breast cancer and provide the basis for developing a combined strategy using miR-128 mimics and chemotherapy.Dysregulated c-MET signaling plays important roles in many cancers and represents an attractive therapeutic target. Liu and colleagues discovered a highly selective and potent c-MET kinase inhibitor, INCB28060. INCB28060 effectively inhibits c-MET–dependent signaling and neoplastic activity in various preclinical models. Furthermore, c-MET upregulates epidermal growth factor receptor and HER3 activity through interaction with these receptors and/or by inducing their ligands, and this activity can be reversed by INCB28060. Although numerous c-MET pathway inhibitors are being developed, they may have limitations in their potency, selectivity, pharmacokinetics, safety profile, or mechanisms of action. The properties shown by INCB28060 may enable this agent to overcome these limitations and allow for assessment of the therapeutic potential of c-MET pathway inhibition.
Treatment of Dysmenorrhea
Authors: Roger P. Smith
Journal: JAMA (1982)

<h3>To the Editor.—</h3> In her letter (1981; 246:2576), Penny W. Budoff, MD, fails to grasp or at least make clear several fundamental points in the use of nonsteroidal anti-inflammatory (NSAI) drugs in the treatment of primary dysmenorrhea. Dr Budoff seems to lump all NSAI drugs together as if they were somehow generically equivalent to each other. The "chemical idiosyncrasy" that she invokes to explain differing degrees of action represents only the difference between drugs derived from different sources (proprionic acid derivatives and anthranilic acid derivatives) with differing mechanisms of action (prostaglandin synthetase inhibitors and synthetasereceptor site blockers). By understanding the pharmacology of these drugs, a drug with specific reactions may be selected to match the specific needs of the patient. A second, more fundamental oversight occurs when Dr Budoff assumes that "resistance" or treatment failure represents an inconvenience requiring little more than generic substitution. Drugs of the NSAI group are
Emergency Medical Care and the Public Purse
Authors: Robert E. Tranquada
Journal: JAMA (1996)

The issues raised in the article by Cornwell and colleagues<sup>1</sup>in this issue ofThe Journalare particularly poignant for Los Angeles County, with its 87 cities, population of 9.2 million, and a county budget in excess of those of 42 of the states. A closer look, however, reveals that there are lessons and portents for much of the rest of the United States. The threatened closure of a critical community medical resource in order to meet politically guided budgetary priorities at a time of enormous change in the financing and organization of health care is not a unique phenomenon in the United States today. There are unique circumstances in Los Angeles County. The population continues to grow as the arithmetic sum of major Euro-American flight, immigration dominated by the Pacific Rim countries, and a substantial birth rate, particularly among newly arrived groups. In 1994 there were 220 000
Gastric Cancer in Colombia IV. Nitrite and Other Ions in Gastric Contents of Residents From a High-Risk Region<xref ref-type="fn" rid="FN1">2</xref>
Authors: Steven R. Tannenbaum, Dennis Moran, William Rand, Carlos Cuello, Pelayo Correa
Journal: JNCI Journal of the National Cancer Institute (1979)

Samples of gastric contents from 2 groups of patients from a region of high risk for gastric cancer were analyzed for pH, nitrite, nitrate, thiocyanate, and chloride. In each group, the patients could be divided into 2 subgroups: those with a gastric pH of less than 5 and those with a gastric pH of greater than 5. Above pH 5, nitrite was correlated with nitrate. The pH >5 subgroups had significantly higher (P<O.01) nitrite content (20- to 100-fold). Some high- and low-nitrite samples were also analyzed for macro and trace metal ions, but differences were not significant. This is the first report in which patients with diagnosed gastric pathology related to a precancerous state were shown to have high levels of a putative carcinogen precursor. The results were compatible with our original hypothesis of intragastric nitrite formation by bacterial reduction of nitrate and concomitant synthesis of carcinogenic N-nitroso compounds.
Ureteroenteric Fistula Shown Only on Bone Imaging
Authors: MASASHI OHTA., NORIYO MATSUNO, KOUICHI ISOBE, JUNPEI KUYAMA, YOSITAKA UCHIDA, KATUHIRO NASU, HIROO IKEHIRA, KIMIITI UNO,
Journal: Clinical Nuclear Medicine (1997)

A 70-year-old woman who had a left neck tumor underwent bone scintigraphy for the purpose of detecting bone metastases. Increased uptake appeared in the right side of abdomen. Among the entities that were suspected were urinoma, ureteroenteric fistula, and gastrointestinal bleeding. Other imaging studies were not rewarding; a Tc-99m HMDP dynamic study showed the flow of the radiopharmaceutical from ureter to ascending colon.
Cutaneous Complications in Immunosuppressed Renal Homograft Recipients
Authors: Frank C. Koranda
Journal: JAMA (1974)

Skin complications were studied in a consecutive series of 200 renal transplant patients treated with immunosuppressive agents. Cushing syndrome changes were the most common reaction, more than half of the patients having altered fat distribution, steroid-induced acne, atrophic and friable skin, striae, dry skin, and keratosis pilaris. Cytotoxic alopecia was encountered in 54%, but hair regrew in all cases. Skin infections were common, especially verrucae (43%), herpes simplex (35%), herpes zoster (13%), and tinea versicolor (18%). De novo skin cancers occurred in 3.5%. Other disorders included acanthosis nigricans, cold intolerance of the front teeth, metastatic calcification, red lunulae of the nails, and hyperpigmentation of exposed skin. Skin complications in transplant patients ranged from minor annoyances to life-threatening conditions. The frequency of dermatologic problems and the possible sequelae stress the need for periodic examinations by a dermatologist and for education of the patients in the care of their skin. (<i>JAMA</i>229:419-424, 1974)