tbuckley/cabot-search huggingface dataset:
The Medical Record Visiting List or Physician's Diary for 1919.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Neurology (2017)

De Giuli and coauthors investigated the association of migraine and spontaneous cervical artery dissection (CEAD) in a case-control study including 2485 consecutive patients aged 18 to 45 years with fi rst-ever ischemic stroke (IS) as part of the multicenter Italian Project on Stroke in Young Adults.Migraine was more common among the 103 patients with IS due to CEAD than among the 525 patients with IS due to another cause (30.8% vs 24.4%).Migraine without aura subtype was independently associated with IS due to CEAD (odds ratio, 1.74; 95% CI, 1.30-2.33),especially in men and in patients who were 39.0 years or younger.Editorial perspective is provided by Lyden.
Session F: Lymphomas – Leukemias – Myelomas – PBFC
Authors: G Azzarello, 'e Balducci, M Valenti, G Capuzzo, G Pappagallo, 'm Ban, A Porcellini, A Ciappa, O Vinante, C Biancfu, D Pedretn, M Tomirolri, V Fossan, A Scanni, Campiotti Pignt
Journal: Annals of Oncology (2000)
Learning forestry out of the lumberyard. A training alternative for primary care
Authors: J. E. Verby
Journal: JAMA (1981)

Undergraduate clinical training typically involves short-term "rotations" in a tertiary care health center. While such a structure is highly conducive to learning in various specialties, it is particularly limiting to the student's acquisition of the wide array of clinical abilities necessary for primary care. An alternative model is the use of a long-term preceptorship in a primary care setting. This provides training with a more representative patient population and offers a richer clinical experience. An example of this model is a Minnesota program that allows third-year undergraduate medical students to spend nine to 12 months in select primary care settings while receiving ongoing teaching visits from university faculty in major specialty areas. The model can be a legitimate alternative for early clinical education of primary care physicians. (<i>JAMA</i>1981;246:645-647)
Mainstreaming genetic counselling for genetic testing of BRCA1 and BRCA2 in ovarian cancer patients in Malaysia (MaGiC study)
Authors: S.Y. Yoon, N.S.Ahmad. Bashah, S.W. Wong, S. Mariapun, T. Hassan, H. Padmanabhan, J. Lim, S.Y. Lau, N. Rahman, M.K. Thong, G.S. Ch'Ng, S.H. Teo, E. Bleiker, Y.L. Woo
Journal: Annals of Oncology (2017)
Cholecystokinin-Enhanced Cholescintigraphy in the Diagnosis of Gallbladder Disease
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LEUCOCYTOSIS IN TYPHOID FEVER.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Doppler indices of left ventricular filling and risk of atrial fibrillation: The framingham heart study Ramachandran S. Vasan, Martin G. Larson, Daniel Levy, Maurizio Galderisi, Philip A. Wolf, Emelia J. Benjamin. NHLBI's Framingham Heart Study, Framingham, MA, Boston University School Of Medicine, Boston, MA
Journal: Journal of the American College of Cardiology (2001)
Chronic IFNγ Production Induces Anemia by Reducing Erythrocyte Lifespan and Inhibiting Erythropoiesis through An IRF-1/PU.1-Axis
Authors: Sten F. W. M. Libregts, Laura Gutierrez, Alexander M. de Bruin, Felix M. Wensveen, Petros Papadopoulos, Wilfred van Ijcken, Zeliha Ozgur, Sjaak Philipsen, Martijn A. Nolte
Journal: Blood (2010)
Fatal syncytial virus pneumonia in a laminar airflow room
Authors: L. R. Crane
Journal: JAMA (1981)

A rapidly progressive, fatal pneumonia occurred during the third week of hospitalization in an immunosuppressed man confined in a laminar airflow room. Respiratory syncytial virus was isolated from open lung biopsy tissue. Epidemiologic data suggested that the virus was community acquired. Respiratory syncytial virus should be considered in the differential diagnosis of pneumonia in severely immunocompromised adults. (<i>JAMA</i>1981;246:366-368)
Regulatory status of pancreatic enzyme preparations
Authors: P. H. Rheinstein
Journal: JAMA (1990)

Hendeles and colleagues<sup>1</sup>report on three patients, each of whom took the same defective pancreatic enzyme product and each of whom obtained an unsatisfactory result. The product consisted of capsules of pancrelipase, US Pharmacopeia (USP) formulated into enteric-coated spheres. The product was sold under various names, but all brands were manufactured by and were labeled as having been manufactured by Anabolic, Inc of Irvine, Calif. Information regarding the defective product, including reports of testing conducted by the independent laboratory (Pharmichem Testing Services) and by a competitor, had been received at the Food and Drug Administration (FDA) by May 1989. The FDA's inspection of the firm revealed that there was no validation for the enteric coating process. Testing conducted by the firm confirmed that the enteric coating was ineffective. All lots were either subpotent or superpotent for one or more active ingredients. On June 14,1989, the manufacturer voluntarily instituted a
Epithelial-mesenchymal transition in cultured neonatal hepatocytes*1
Authors: R PAGAN
Journal: Hepatology (1995)

When hepatocyte-enriched fractions from neonatal rat livers were cultured for different times in the absence of added growth factors, a population of highly proliferating and migrating fibroblastlike cells appeared. Double immunofluorescence with antibodies to cytokeratin and to vimentin showed a progressive reduction in the number of cytokeratin-positive cells parallel to an increase in the vimentin-positive cells. Some cells with transitional epithelial or migrating morphology coexpressed both intermediate filament proteins. Immunofluorescence with antibodies against hepatocyte differentiation markers showed that shortly after seeding most of the cells were positive to anti-albumin antibodies, but after 1 week in culture, only 10% were positive. Cells presenting albumin and cytokeratin appeared morphologically epithelial. Fibroblastlike cells were not positive for albumin, but some cells with transitional epithelial morphology presented some labels for albumin and for vimentin. Immunofluorescence with antibodies to glutathione-S-transferase subunit Pi and vimentin showed that many fibroblastlike cells were positive for both markers, some of them binucleate. Cultures performed in the presence of dexamethasone, absence of arginine, or on collagen type I matrix had no effect on the behavior of neonatal hepatocytes. The appearance of fibroblastlike cells was ontogenically regulated because the highest increase in the percentage of vimentin-positive cells was observed in cell cultures from livers of 7-and 15-day-old animals. These data provide evidence that neonatal hepatocytes in culture have the potential to dedifferentiate by epithelial-mesenchymal transition and contribute to an understanding of hepatic growth development.
Investigation of Peanut Oral Immunotherapy Using CpG/Peanut-Nanoparticles in a Murine Model of Peanut Allergy
Authors: Kamal D. Srivastava, Alyssa Siefert, Tarek Fahmy, Michael J. Caplan, Xiu-Min Li, Hugh A. Sampson
Journal: Journal of Allergy and Clinical Immunology (2015)
State-Specific Trends in High Blood Cholesterol Awareness Among Persons Screened—United States, 1991-1999
Journal: JAMA (2001)

High blood cholesterol (HBC) is a major risk factor for heart disease. One of the national health objectives for 2010 is to reduce the percentage of adults aged > or = 20 years with total blood cholesterol levels of > or = 240 mg/dL (objective 12-14). One strategy for achieving this objective is to increase awareness of HBC. State-specific data allow state health departments to monitor progress in educating the public about awareness of cholesterol levels and the need for persons to maintain low levels of blood cholesterol. To examine state-specific trends in the proportion of screened adults who reported that they were told that they had HBC, CDC analyzed data from the Behavioral Risk Factor Surveillance System (BRFSS) for 1991 through 1999. This report summarizes the results of that analysis and indicates that approximately one fourth of screened survey participants were aware that they had HBC; this proportion increased slightly from 1991 through 1999. Awareness of HBC is a necessary step to help persons take action to lower their cholesterol level and their risk for coronary heart disease.
Development of an Effective Safety Switch for Selective Elimination of Human T Cells In Vivo after Adoptive Transfer.
Authors: Tom van Meerten, Henk Rozemuller, Wendy J.M. Mackus, Paul W.H.I. Parren, Jan G.J. van de Winkel, Marie-Jose Claessen, Rozemarijn S. van Rijn, Anton Hagenbeek, Anton C.M. Martens, Saskia B. Ebeling
Journal: Blood (2006)
Highlights
Journal: JAMA Internal Medicine (2019)

Calcium-Free vs Calcium-Based Phosphate Binders 741In this observational study, Spoendlin and colleagues compared cardiovascular events and mortality in the use of sevelamer (calcium-free phosphate binder) vs calcium acetate (calciumbased phosphate binder) for treatment of hyperphosphatemia in patients 65 years and older with end-stage renal disease who were undergoing hemodialysis.The study cohort was analyzed using the United States Renal Data System linked to Medicare claims data.Results did not suggest increased cardiovascular safety of sevelamer in the routine clinical practice of patients with end-stage renal disease compared with calcium acetate.Kestenbaum and de Boer provide the Invited Commentary.
GASES IN MODERN WARFARE
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pain
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Should All Patients with Type 1 Diabetes Mellitus and Microalbuminuria Receive Angiotensin-Converting Enzyme Inhibitors?
Journal: Annals of Internal Medicine (2001)

Purpose: To determine whether response of albumin excretion rate to angiotensin-converting enzyme (ACE) inhibitors has a threshold in patients with type 1 diabetes mellitus and microalbuminuria and to examine treatment effect according to covariates. Data Sources: Studies were identified by searching MEDLINE and related bibliographies. Study Selection: Selected studies included at least 10 normotensive patients with type 1 diabetes mellitus and microalbuminuria, had a placebo or nonintervention group, and included at least 1 year of follow-up. Data Extraction: Raw data were obtained for 698 patients from the 12 identified trials. Analysis of treatment effect at 2 years was restricted to trials with at least 2 years of follow-up (646 patients from 10 trials). Data Synthesis: In patients receiving ACE inhibitors, progression to macroalbuminuria was reduced (odds ratio, 0.38 [95% CI, 0.25 to 0.57]) and the odds ratio for regression to normoalbuminuria was 3.07 (CI, 2.15 to 4.44). At 2 years, albumin excretion rate was 50.5% (CI, 29.2% to 65.5%) lower in treated patients than in those receiving placebo (P�<�0.001). Estimated treatment effect varied by baseline albumin excretion rate (74.1% and 17.8% in patients with a rate of 200 µg/min and 20 µg/min, respectively [P�=�0.04]) but not by patient subgroup. Adjustment for change in blood pressure attenuated the treatment difference in albumin excretion rate at 2 years to 45.1% (CI, 18.6% to 63.1%; P�<�0.001). Conclusions: In normotensive patients with type 1 diabetes mellitus and microalbuminuria, ACE inhibitors significantly reduced progression to macroalbuminuria and increased chances of regression. Beneficial effects were weaker at the lowest levels of microalbuminuria but did not differ according to other baseline risk factors. Changes in blood pressure cannot entirely explain the antiproteinuric effect of ACE inhibitors. *For members of the ACE Inhibitors in Diabetic Nephropathy Trialist Group, see Appendix.
A simple genetic test identifies 90% of UK patients with haemochromatosis
Journal: Gut (1997)

The diagnosis of genetic haemochromatosis (GH) before iron overload has developed is difficult. However a convincing candidate gene for GH, HFE (previously HLA-H), has been described recently.To determine the prevalence of the haemochromatosis associated HFE mutations C282Y and H63D in United Kingdom affected and control populations.The prevalence of the HFE C282Y and H63D mutations was determined by polymerase chain reaction amplification and restriction enzyme digestion in a cohort of 115 well characterised patients with GH and 101 controls from the United Kingdom.One hundred and five of 115 (91%) patients with GH were homozygous for the C282Y mutation. Only one of 101 (1%) controls was homozygous for the C282Y mutation and this individual currently shows evidence of iron overload. Two of five patients who did not have either of the two described mutations of HFE had early onset iron overload (ages 16 and 24). One had a family history of cardiac failure and the second was subsequently hospitalised due to cardiac failure. These are the first phenotypic observations for patients without either C282Y or H63D mutation of HFE.This simple genetic test promises to be a highly effective tool in the diagnosis of GH.
Clinical Laboratory Medicine: Clinical Application of Laboratory Data
Authors: Stebbins B. Chandor
Journal: JAMA (1984)

This is the fourth edition of a recognized useful text in a complex and expanding field. Many new procedures have been added since publication of the previous edition in 1978. The first chapter discusses the interpretations of laboratory data and reviews concepts of sensitivity and specificity. This is an important addition, and perhaps the actual equations used to determine terms such as "specificity" can be included in the future. From chapters 2 through 34, the clinical procedures are broken down into organ- or disease-oriented sections. Finding a given disease state and the related relevant test is easy to do in this well-organized text. Most of the chapters are in sentence form; but where graphs and charts have proved to be helpful, such as in the chapters on infectious diseases and serum proteins, they are used in a concise manner. Chapter 35, entitled "Special Category Tests," is an addendum to each
Burden of Infection and Insulin Resistance in Healthy Middle-Aged Men
Authors: José-Manuel Fernández-Real, Abel López-Bermejo, Joan Vendrell, Maria-José Ferri, Mónica Recasens, Wifredo Ricart
Journal: Diabetes Care (2006)

OBJECTIVE—We hypothesized that burden of infection could be associated with chronic low-grade inflammation, resulting in insulin resistance. We aimed to study the effect of exposure to four infections on insulin sensitivity in apparently healthy middle-aged men (n = 124). RESEARCH DESIGN AND METHODS—By inclusion criteria, all subjects were hepatitis C virus antibody seronegative. Each study subject’s serum was tested for specific IgG class antibodies against herpes simplex virus (HSV)-1, HSV-2, enteroviruses, and Chlamydia pneumoniae through the use of quantitative in vitro enzyme-linked immunosorbent assays. Insulin sensitivity was evaluated using minimal model analysis. RESULTS—The HSV-2 titer was negatively associated with insulin sensitivity even after controlling for BMI, age, and C-reactive protein (CRP). The associations were stronger when considering the infection burden. In particular, in those subjects who were seropositive for C. pneumoniae, the relationship between the quantitative seropositivity index (a measure of the exposure to various pathogens) and insulin sensitivity was strengthened (r = −0.50, P &amp;lt; 0.0001). We also observed decreasing mean insulin sensitivity index with increasing seropositivity score in subjects positive for enteroviruses. In the latter, the relationship between insulin sensitivity and seropositivity was especially significant (r = −0.71, P &amp;lt; 0.0001). In a multivariate regression analysis, both BMI and quantitative seropositivity index (7%) independently predicted insulin sensitivity variance in subjects with C. pneumoniae seropositivity. When controlling for CRP, this association was no longer significant. CONCLUSIONS—Pathogen burden showed the strongest association with insulin resistance, especially with enteroviruses and C. pneumoniae seropositivity. We hypothesize that exposure to multiple pathogens could cause a chronic low-grade inflammation, resulting in insulin resistance.
Pediatric Orthopedics
Authors: Jonathan Cohen
Journal: JAMA (1973)

This is a textbook on children's orthopedics designed for orthopedic surgeons in practice or in training. It is classical in its approach, starting with the details of history taking, physical examination, and diagnosis and then proceeding to a full discussion of the pertinent conditions. It strikes a good balance between details of operative treatment and the other aspects of each problem—etiological, diagnostic, and therapeutic. Two main uses will be served by this book. First, those in training for orthopedic specialization will find in it a competent portrayal of all important clinical aspects of children's orthopedics. One might say that if anyone knew and practiced all that is in this two-volume set he would be an excellent if not superb children's orthopedic surgeon. Second, this book will serve as a reference or review for practicing orthopedists not familiar with some specific conditions or specific treatment. The book is better organized than