tbuckley/cabot-search huggingface dataset:
Association between House Dust Mite Sensitization and IL4/IL13 and IL4RA Genetic Variants in Nonsteroidal Anti-inflammatory Drug-induced Acute Urticaria/angioedema
Authors: Raquel Jurado-Escobar, Inmaculada Dona, Isabel Jimenez-Sanchez, Almudena Testera-Montes, Natalia Perez-Sanchez, Carmen Rondon, Joan Bartra, Jose Laguna, Rocio Saenz de Santamaria, Marina Labella, Maria Torres, Jose Antonio Cornejo-Garcia
Journal: Journal of Allergy and Clinical Immunology (2023)
Efficacy and Safety of Ligelizumab in Chronic Spontaneous Urticaria: Results from the Phase-3 Pivotal Trials
Authors: Luis Felipe Ensina, Jonathan Bernstein, Gordon Sussman, Marcus Maurer, Ana Maria Giménez-Arnau, Sarabjit Saini, Vineeth Varanasi, Avantika Barve, Eva Hua, Manmath Patekar, Thomas Severin
Journal: Journal of Allergy and Clinical Immunology (2023)
Longitudinal skin tape strip global proteomic assessment reveals normalization of epidermal development in atopic dermatitis patients treated with dupilumab
Authors: Elena Goleva, Evgeny Berdyshev, Simion Kreimer, Taras Lyubchenko, Clifton Hall, Brittany Richers, Olivia Xiao, Shantanu Bafna, Inoncent Agueusop, Robert Bissonnette, Noah Levit, Annie Zhang, Donald Leung
Journal: Journal of Allergy and Clinical Immunology (2023)
Dupilumab Reduces Inflammatory Biomarkers in Patients Aged 6 Months to 18 Years With Moderate-to-Severe or Severe Atopic Dermatitis
Authors: Lisa Beck, Antonella Muraro, Mark Boguniewicz, Zhen Chen, Noah Levit, Ainara Rodríguez Marco
Journal: Journal of Allergy and Clinical Immunology (2023)
Characteristics Of Peach Allergy In Madrid
Authors: Isabel Torres Rojas, Laura Martín Pedraza, Elisa Haroun-Diaz, Maria Vazquez de La Torre, Laura Victorio Puche, Enrique Enrique Fernández Caldas, José Damián López Sánchez, Francisco Javier Ruano, Ángel Esteban Rodriguez, Miguel Blanca Gómez, María Luisa Somoza Alvarez
Journal: Journal of Allergy and Clinical Immunology (2023)
A New Algorithm Identifying Association of Staphylococcus aureus Strains with Low Expression of Filaggrin in Atopic Dermatitis
Authors: Latha Satish, Wan-Chi Chang, Arya Dahal, Elizabeth Johansson, None makenna eversole, Matthew Schuetz, Brittany Grashel, None daniel spagna, None seth jenkins, None veronica velasquez, Andrew Herr, Jocelyn Biagini, None david haslam, Lisa Martin, Gurjit Khurana Hershey
Journal: Journal of Allergy and Clinical Immunology (2023)
How low can we go: preliminary efficacy of very low dose peanut oral immunotherapy
Authors: Julia Upton, Duncan Lejteyni, Danbing Ke, Alireza Berenjy, Liane Beaudette, Christine McCusker, Xiaojun Yin, Carmen Li, Lucy Duan, Shireen Marzouk, Eyal Grunebaum, Thomas Eiwegger, Moshe Ben-Shoshan
Journal: Journal of Allergy and Clinical Immunology (2023)
N-glycans Other Than MUXF3 Are Targets For Specific IgE Antibodies Against Juniperus ashei Pollen Allergens
Authors: Javier Alvarez, Tamara Aranda, Rocio Ruiz, Leire Aramendia, Niels-Christian Reichardt, Jeronimo Carnes
Journal: Journal of Allergy and Clinical Immunology (2023)
Effectiveness, Safety, and Patient-Reported Outcomes (PROs) in Patients With Hereditary Angioedema (HAE) From the United States and Canada Treated With Lanadelumab: 24-Month Data From the EMPOWER Study
Authors: H. James Wedner, Jonathan Bernstein, Stephen Betschel, Michael Manning, Daniel Nova Estepan, Kezhen Fei, Ashley Yegin, Maureen Watt, Sunetra Chavan, Paula Busse
Journal: Journal of Allergy and Clinical Immunology (2023)

24-month interim analysis of EMPOWER (NCT03845400), a Phase IV observational, non-interventional, multicenter study in patients with HAE Type 1/2 from the United States and Canada, expands on previously reported 12-month data. The primary objective is real-world effectiveness of lanadelumab as measured by comparing HAE attack rates before and after lanadelumab initiation. Other objectives include PROs (the Angioedema Quality of Life Score [AE-QoL], the Angioedema Control Test [AECT]) before and after lanadelumab initiation. Safety data are also collected. From March 30, 2019 to March 1, 2022, 102 patients with ≥1 lanadelumab dose and ≥1 post-baseline effectiveness assessment were enrolled: 15 new and 87 prevalent (<4 and ≥4 lanadelumab doses at enrollment, respectively) lanadelumab users. In new lanadelumab users, HAE attack rate decreased from 1.07 (pre-lanadelumab) to 0.22 (post-lanadelumab initiation) attacks/month (79% reduction; 95% CI 72%, 85%). Prevalent lanadelumab users maintained low HAE attack rate (0.16 attacks/month). In 10 new lanadelumab users aged ≥18 years, the mean(SD) AE-QoL total score decreased (lower impairment; enrolment: 42.2[20.1], month 24: 21.3[1.0]), and mean[SD] AECT total score increased (improved control; enrolment: 7.4[3.4], month 24: 14.0[2.8]). 38/107 patients with ≥1 lanadelumab dose experienced 96 treatment-emergent adverse events (TEAEs; 95.8% non-serious, 94.8% mild/moderate). No discontinuations were related to lanadelumab treatment. Real-world findings from EMPOWER show HAE attack rate reduction, improved QoL, and improved angioedema control after lanadelumab initiation in new lanadelumab users. Low attack rates were maintained in prevalent lanadelumab users, supporting long-term effectiveness. Most TEAEs were non-serious and mild/moderate in severity; no patients discontinued due to lanadelumab.
Baseline Epitope-Specific IgE Profiles are Predictive of Sustained Unresponsiveness One Year Post OIT in the POISED Trial
Authors: Ashley Sang Eun Lee, Maria Suprun, Robert Getts, Simon Peck, Sayantani Sindher, Kari Nadeau, R. Sharon Chinthrajah, Stephen Galli, Hugh Sampson
Journal: Journal of Allergy and Clinical Immunology (2023)
Circulating group 2 innate lymphoid cells drive a Th2 cell response in food-allergic patients
Authors: Francisca Palomares, Nazaret Nieto, Carmen Ramírez, Rafael Núñez, José Antonio Cañas, María del Carmen Martin-Astorga, Ana Molina Bueno, Anyith Cruz-Amaya, Maria Torres Jaen, Cristobalina Mayorga, Francisca Gomez Perez
Journal: Journal of Allergy and Clinical Immunology (2023)
Flow cytometry-based immunoassays for determining functional levels of plasma protease C1 inhibitor for the diagnosis of hereditary angioedema (HAE)
Authors: Kusumam Joseph, Baby Tholanikunnel, Jing Yu, Zhu Qian, Jiafang Sun, Abby Sun, Lili Wan, Joseph Chiao, H. Henry Li
Journal: Journal of Allergy and Clinical Immunology (2023)
IL-4 And IL-13 Have Distinct And Overlapping Effects On Key Cell Types Involved In The Pathobiology Of Atopic Dermatitis
Authors: Subhashini Srivatsan, Audrey Le Floch-ramondou, Kirsten Nagashima, Brianna Buonagurio, Angelos Pappatheodorou, Wei Keat Lim, Andrew Murphy, Matthew Sleeman, Jamie Orengo
Journal: Journal of Allergy and Clinical Immunology (2023)
CARD14 is a Novel Regulator of MYC Expression and Function in Human Keratinocytes
Authors: Stanley DeVore, Matthew Schuetz, Henry Lujan, David Ohayon, Arjun Kothari, Hua He, Jennifer Hahn, Latha Satish, Andrew Herr, Jocelyn Biagini, Lisa Martin, Dorothy Supp, Gurjit Khurana Hershey
Journal: Journal of Allergy and Clinical Immunology (2023)
Safety and Clinical Activity of Multiple Doses of Barzolvolimab, an anti-KIT Antibody, in Patients with Chronic Spontaneous Urticaria
Authors: Marcus Maurer, Martin Metz, John Anderson, Neetu Talreja, Hugh Windom, Diego Alvarado, Elizabeth Crowley, Diane Young, Kunal Merchant, ELsa Paradise, Margo Heath-Chiozzi, Jonathan Bernstein
Journal: Journal of Allergy and Clinical Immunology (2023)
Real-World Survey Outcomes For Chronic Spontaneous Urticaria For Patients On Omalizumab Versus Patients Eligible For Omalizumab
Authors: Michael Holden, Jonathan Bernstein, Arpamas Seetasith, Vincent Garmo, James Hetherington, Ben Hoskin, Eleanor Wrest, Thomas Casale
Journal: Journal of Allergy and Clinical Immunology (2023)
Evaluating the Impact of Acute Versus Prophylaxis Therapy in Hereditary Angioedema
Authors: Kristen Park, Andrew Yeich, Timothy Craig
Journal: Journal of Allergy and Clinical Immunology (2023)

Hereditary Angioedema (HAE) is a debilitating disease consisting of unpredictable swelling attacks. We sought to determine the impact of different HAE treatments on quality of life and hypothesized that patients on long-term prophylaxis (LTP) would experience better quality of life compared to patients on acute therapy (AT). Phone call surveys with HAE patients either on AT or LTP were performed, using four questionnaires focused on different aspects of quality of life. These included the Work and Productivity Index (WPAI), Hospital Anxiety and Depression Scale (HADS), Treatment Satisfaction Questionnaire for Medication – 9 items (TSQM-9), and Hereditary Angioedema Quality of Life (HAE-QoL). Patients on AT were then compared to patients on LTP using the Wilcoxon Rank Sum test. HAE patients on LTP were more likely to experience better quality of life in various aspects compared to patients on AT. Daily activity impairment (WPAI) was more likely to be exhibited in patients taking AT (p = 0.004). In addition, anxiety (p = 0.001) and depression (p = 0.011) were more likely associated with AT (HADS). Medication satisfaction (TSQM-9) was not significant between groups. Lastly, statistical analysis for the HAE-QoL questionnaire indicated more disease-related stigma (p = 0.012), less emotional and social function (p = 0.029), less perceived control over illness (p = 0.012), and worse mental health (p = 0.006) in AT patients. Analysis of AT versus LTP therapies suggests that LTP with any of the FDA-approved therapies improve QoL more than depending only on FDA-approved acute therapies for HAE.
Dupilumab suppresses type 2 biomarkers of inflammation in patients with eosinophilic esophagitis: from Part B of LIBERTY-EoE-TREET
Authors: Ikuo Hirano, Marc Rothenberg, Evan Dellon, Margaret Collins, John Leung, Alain Schoepfer, Xian Sun, Julie Horowitz, Danen Cunoosamy, Kiran Patel, Arsalan Shabbir, Alexandra Hicks, Jennifer Hamilton
Journal: Journal of Allergy and Clinical Immunology (2023)
Correlation between the basophil activation test and the severity of rhinitis in local respiratory allergy
Authors: Almudena Testera Montes, Marta Espada, Maria Jesus Delgado-Gámez, Carlos Aranda, Carmen Alba, Raquel Jurado-Escobar, Adriana Ariza Veguillas, Cristobalina Mayorga, Maria Torres Jaen, Ibon Eguiluz-Gracia, Carmen Rondon Segovia
Journal: Journal of Allergy and Clinical Immunology (2023)
Remibrutinib Improves Chronic Spontaneous Urticaria in Patients Irrespective of Previous Anti-IgE Treatment: Results From a Phase 2b Study
Authors: Alexander Greiner, Sridhar Guduri, Jeffrey Leflein, Sibylle Haemmerle, Karine Lheritier, Pauline Walsh, Ivan Nikolaev, Ana Giménez-Arnau, Marcus Maurer
Journal: Journal of Allergy and Clinical Immunology (2023)
Asthma Morbidity Measures Across Black Ethnic Subgroups
Authors: Leah Ishmael, Juan Carlos Cardet, Barbara Yawn, Thomas Casale, Juan Celedon, Paula Busse, Nancy Maher, Giselle Mosnaim, Andrea Apter, Brianna Ericson, Tamera Coyne-Beasley, Isaretta Riley, Wanda Phipatanakul, Michael Foggs, Rubin Cohen, Victor Pinto-Plata, Kartik Shenoy, Juan Wisnivesky, Jennifer Carroll, David Kaelber, Conner Merriman, Sylvette Nazario, Rafael Calderon-Candelario, Joel Shields, Paulina Hernandez, Elliot Israel
Journal: Journal of Allergy and Clinical Immunology (2023)
Identification of MOD000001, A Novel Highly Selective and Orally Available KIT Inhibitor Designed for Treatment of Mast Cell-Associated Disorders
Authors: Takeo Urakami, Taisuke Takahashi, Takafumi Shimizu, William Sinko, Yuki Nakamura, Kayoko Ishimaru, Vuong Tran, Ramulu Poddutoori, Kishore Narayanan, Sivapriya Marappan, Atsuhito Nakao, Yoh Terada
Journal: Journal of Allergy and Clinical Immunology (2023)
Efficacy and Safety of Subcutaneous Garadacimab for the Prophylaxis of Hereditary Angioedema Attacks in Adults and Adolescent Patients with HAE: Results from a Multicenter, Placebo-Controlled Phase 3 Trial
Authors: Timothy Craig, Markus Magerl, Avner Reshef, Huamin Li, Joshua Jacobs, Jonathan Bernstein, Henriette Farkas, William Yang, Erik Stroes, Isao Ohsawa, Raffi Tachdjian, Michael Manning, William Lumry, Inmaculada Martinez Saguer, Emel Aygören-Pürsün, Bruce Ritchie, Gordon Sussman, John Anderson, Kimito Kawahata, Yusuke Suzuki, Petra Staubach, Regina Treudler, Henrike Feuersenger, Lolis Wieman, Iris Jacobs
Journal: Journal of Allergy and Clinical Immunology (2023)
Long-term HAE Prophylaxis with Berotralstat Is Well Tolerated and Effective: Analysis for the APeX-S Study
Authors: Emel Aygören-Pürsün, Michael Manning, Olivier Fain, Bhavisha Desai, Dianne Tomita, Douglas Johnston, H. Henry Li, Sorena Kiani-Alikhan
Journal: Journal of Allergy and Clinical Immunology (2023)
Comparison of Selected Health and Well Being Characteristics in Seniors with Hereditary Angioedema (HAE) and a Non-HAE Patient Matched Cohort
Authors: Tony Castaldo, Christine Selva, Phaedra Johnson, Alyssa Goolsby Hunter, Jenny Tse, Ana Martinez, Aaron Cortright, Hannah Carroll, Helen Chen, William Lumry
Journal: Journal of Allergy and Clinical Immunology (2023)
Mechanisms of airway disease development following inhalation exposure to indoor fungal contaminants Stachybotrys chartarum and Aspergillus versicolor
Authors: Catherine Blackwood, Angela Lemons, Rachael Rush, Walter McKinney, Dori Germolec, Donald Beezhold, Brett Green, Tara Croston
Journal: Journal of Allergy and Clinical Immunology (2023)
Assessing Allergic Reactions to Cephalosporins in Children
Authors: Carly Sillcox, Andrew O’Keefe, Christine McCusker, Sofianne Gabrielli, Elissa Abrams, Thomas Eiwegger, Adelle Atkinson, Vy Kim, Ana-Maria Copaescu, Moshe Ben-Shoshan
Journal: Journal of Allergy and Clinical Immunology (2023)
Real-World Impact of Systemic Corticosteroid (SCS) Exposure on Healthcare Resource Utilization (HRU) due to SCS-Related Complication among Patients with Asthma in the US
Authors: Thomas Corbridge, Thomas Casale, Guillaume Germain, François Laliberté, Sean Macknight, Julien Boudreau, Mei Sheng Duh, Arijita Deb
Journal: Journal of Allergy and Clinical Immunology (2023)
Viral Neutralization Against SARS-CoV-2 is More Durable After Infection Versus Vaccination
Authors: Kelsea Chen, Kelly O'Shea, Charles Schuler, Jesse Chen, Jonathan Troost, Pamela Wong, Daniel O'Shea, Westley Peng, Carmen Gherasim, David Manthei, Riccardo Valdez, James Baldwin, James Baker
Journal: Journal of Allergy and Clinical Immunology (2023)
CCL5 is a Potential Bridge Between Type 1 and Type 2 Inflammation in Asthma
Authors: Marc Gauthier, Sagar Kale, Timothy Oriss, Michael Gorry, Richard Ramonell, Kathryn Scholl, Prabir Ray, John Fahy, Max Seibold, Mario Castro, Nizar Jarjour, Benjamin Gaston, Eugene Bleecker, Deborah Meyers, Wendy Moore, Annette Hastie, Elliot Israel, Bruce Levy, David Mauger, Serpil Erzurum, Suzy Comhair, Sally Wenzel, Anuradha Ray
Journal: Journal of Allergy and Clinical Immunology (2023)
Comparison of Rhinitis Phenotypes with the Development of Asthma by Age 10 in an Urban Birth Cohort
Authors: Ross Tanis, Agustin Calatroni, Leonard Bacharier, Frederic Little, Megan Sandel, Katherine Rivera-Spoljaric, Cynthia Visness, Alkis Togias, Peter Gergen, James Gern, Sima Ramratnam, Carin Lamm, Robert Wood, Molly Johnson
Journal: Journal of Allergy and Clinical Immunology (2023)
A Qualitative Study of the Experiences and Changes in the Daily and Occupational Activities of Allergists and Otolaryngologists due to the COVID-19 Pandemic
Authors: Elizabeth Garcia, Lucia PEREZ, ADRIANA MARTÍNEZ, SERGIO MORENO, DANIEL PEÑARANDA, None NARANJO, GILMA ALDANA, IRENE PEREZ, Edgardo Chapman, AUGUSTO PEÑARANDA, GLORIA CORREDOR
Journal: Journal of Allergy and Clinical Immunology (2023)
Effect of Abrocitinib and Dupilumab on Eosinophil Levels in Patients With Moderate-to-Severe Atopic Dermatitis and With or Without Comorbid Asthma or Allergic Rhinitis: A Post Hoc Pooled Analysis of JADE COMPARE and JADE DARE
Authors: Bob Geng, Audrey Nosbaum, Mark Boguniewicz, Irina Lazariciu, Claire Feeney, Francisco Rebollo, Herwig Koppensteiner
Journal: Journal of Allergy and Clinical Immunology (2023)
Implementation of a Novel Digital Inhaler Technology in Real-World Clinical Practice: Experiences and Recommendations from Early Adopters
Authors: Priya Bansal, Giselle Mosnaim, Sakina Bajowala, Yihui Jiang, Ewa Schafer, Neil Skolnik, Kaharu Sumino, Charles Vega, Paul Williams, Barbara Yawn, Bradley Drummond, Milena Anatchkova, Marissa Walsh, Amanda Boe, Tanisha Hill
Journal: Journal of Allergy and Clinical Immunology (2023)
Real-World Insights on the burden of Hypereosinophilic Syndrome (HES)
Authors: Anna Kovalszki, Michael Wechsler, Jared Silver, Brian Stone, William McCann, Lynn Huynh, Anamika Khanal, Mingchen Ye, Mei Sheng Duh, Arijita Deb
Journal: Journal of Allergy and Clinical Immunology (2023)
Establishment of a novel IL-25-dependent eosinophilic gastroenteritis mouse model
Authors: Ryo MATSUOKA, Yuka Hayashi, Naoko Nagano, Hiroki Sugiyama, Ayako Yamada, Keisuke Orimo, Kenichiro Motomura, Masashi Ikutani, Ken Arae, Hirohisa Saito, Susumu Nakae, Kenji Matsumoto, Hideaki Morita
Journal: Journal of Allergy and Clinical Immunology (2023)
Comparison Between Tissue and Secretion Samples for Evaluating Endotyping in CRS
Authors: Regan Harmon, Alexander Schneider, Aditi Agarwal, Julia Huang, Lydia Suh, David Conley, Kevin Welch, Robert Kern, Stephanie Shintani-Smith, Anju Peters, Whitney Stevens, Atsushi Kato, Robert Schleimer, Bruce Tan
Journal: Journal of Allergy and Clinical Immunology (2023)
Decreased pollen sensitization in school-age children after the COVID-19 pandemic : COCOA study
Authors: Kun Baek Song, Min Jee Park, Eom Ji Choi, Eun Young Paek, Sungsu Jung, Jisun Yoon, Hyun-ju Cho, Bong Seong Kim, Kangmo Ahn, Kyung Won Kim, Youn Ho Shin, Dong In Suh, Soo-Jong Hong, So-Yeon Lee
Journal: Journal of Allergy and Clinical Immunology (2023)
Dupilumab Improves Urticaria Activity And Quality Of Life In Patients With Chronic Spontaneous Urticaria (CSU)
Authors: Marcus Maurer, Thomas Casale, Sarbjot (Romi) Saini, Moshe Ben-Shoshan, Allen Radin, Bolanle Akinlade, Chunpeng Fan, Deborah Bauer, Elizabeth Laws, Ryan Thomas, Leda Mannent, Aleksandra Stjepanovic
Journal: Journal of Allergy and Clinical Immunology (2023)
Basophil activation test may help achieve a better diagnosis in patients with hypersensitivity reactions to chemotherapeutics
Authors: Gador Bogas Herrera, Adriana Ariza Veguillas, Marina Labella, Inmaculada Doña, Maria Salas, Ruben Fernandez-Santamaria, Jose Antonio Céspedes, Cecilia Frecha, None silvia calvo-serrano, Maria de los Reyes Garcia-Otón, Maria Isabel Montañez, Cristobalina Mayorga, Tahia D. Fernandez, Maria Jose Torres
Journal: Journal of Allergy and Clinical Immunology (2023)
Mepolizumab is ineffective for treatment of episodic angioedema with eosinophilia in a pilot study
Authors: Paneez Khoury, Michelle Makiya, Rodaba Rahim, David Espinoza, Abbie Bowman, Adam Schiffenbauer, Megan Koch, Charles Anderson, Gregory Constantine, Irina Maric, Xiaoping Sun, Thomas Brown, Nicole Holland, JeanAnne Ware, Lauren Wetzler, Michael Fay, Amy Klion
Journal: Journal of Allergy and Clinical Immunology (2023)
Clinical Characteristics of Patients with Eosinophilic Esophagitis in the UK: A Retrospective Analysis of the Clinical Practice Research Datalink (CPRD) Database
Authors: Xiao Xu, E. Maslova, D. Kielar, Justin Kwiatek, S. Chen, H. Stirnadel-Farrant, R. Katial, J. Langham, S. Langham, P. Woodland
Journal: Journal of Allergy and Clinical Immunology (2023)
A Phase 3 Study Evaluating The Efficacy And Safety Of Benralizumab In Patients With Hypereosinophilic Syndrome
Authors: Princess Ogbogu, Amy Klion, Florence Roufosse, Praveen Akuthota, Paneez Khoury, Vivian Shih, Diane Griffis, Himanshu Parikh, Ron Chen, Ying Fan, Gaëll Mayer, Rohit Katial, Ioannis Psallidas
Journal: Journal of Allergy and Clinical Immunology (2023)
Persistence With Benralizumab Among Patients With Severe Eosinophilic Asthma Participating In The CONNECT 360 Patient Support Program
Authors: Adrian P.J. Rabe, Wei Loke, Tamsin Morris, Danuta Kielar, Vivian Shih, Olivia Fulton, Zhiyi Lan, Lynda Olinger, Mihaela Musat, Liam Heaney, Azeem Majeed
Journal: Journal of Allergy and Clinical Immunology (2023)
Patient Profiles in Eosinophilic Granulomatosis with Polyangiitis (EGPA) - Insights from Allergy Practice
Authors: Michael Wechsler, Anna Kovalszki, Jared Silver, Brian Brian, William McCann, Lynn Huynh, Anamika Khanal, Mingchen Ye, Mei Sheng Duh, Arijita Deb
Journal: Journal of Allergy and Clinical Immunology (2023)
Traditional Chinese Medicine's Luffa Formula Reduces Nasal and Ocular Symptoms in Patients with Environmental and Food Allergies
Authors: Zhaoyu Chen, Tory McKnight, Nan Yang, Anish Maskey, Ibrahim Musa, Xiu-Min Li
Journal: Journal of Allergy and Clinical Immunology (2023)

Environmental allergy (EA) often coexists with other inflammatory conditions such as food allergy. It has been previously shown that the Luffa Formula in Traditional Chinese Medicine (TCM) reduces symptoms of allergic rhinoconjunctivitis in a murine model. We conducted a retrospective study on the Luffa Formula's effect in reducing EA symptoms among people with comorbid environmental and food allergies, and conducted an in vitro study on IgE production and mast cell activation. A retrospective cross-sectional study was done on 36 patients, aged 4 to 32, undergoing TCM treatment for both food and environmental allergies. The severity of nasal and ocular symptoms and other clinical information on EA were collected at clinical visits 1 year before treatment initiation and years 0, 1, and 2 post-treatment. Furthermore, a key herbal constituent of the Luffa Formula, Arctium lappa L., was studied for its effects on IgE production and mast cell degranulation. U266 (multiple myeloma) cells and RBL-2H3 (mast) cells were cultured in the presence and absence of Arctium lappa L. extract, and IgE levels and beta-hexosaminidase release were measured. All patients tolerated the formula well. Median nasal, ocular, and respiratory symptom scores, duration of EA symptoms, and scores of medication use were significantly reduced from baseline following 1 and 2 years of treatment (P<0.5-p<0.001). Furthermore, Arctium lappa L. significantly suppressed IgE production and mast cell degranulation (over 90% inhibition) compared to untreated cultures. Luffa Formula may be a potential adjunct treatment to antihistamines for EA in patients comorbid with food allergy.
Increased Population of CD19+CCR6+ Cells Expressing Intracellular IgE in Alpha-Gal Allergic Patients
Authors: Rebekah Browning, Elizaveta Kalaidina, Phan Saligrama, Iris Lee, Tarisa Mantia, Maya Jerath, Peggy Kendall
Journal: Journal of Allergy and Clinical Immunology (2023)
Efficacy And Tolerability Of The Barrier-Forming Drug-Free Nasal Spray AM-301 In Allergic Rhinitis Patients Exposed To Controlled Grass Pollen And House Dust Mite Challenge
Authors: Anne Marie Salapatek, Oliver Pfaar, Patricia Couroux, Julian Nehrig, Nicole Grosse, IIja Hohenfeld, Fabio Fais, Jens Hohlfeld, Phillip Badorrek, Martin Sailer, Assen Koitschev, Sven Becker, Thomas Meyer
Journal: Journal of Allergy and Clinical Immunology (2023)
Drug reaction with eosinophilia and systemic symptoms (DRESS) with dual sensitization to both vancomycin and ceftriaxone
Authors: Matthew Krantz, Andrew Gibson, Ramesh Ram, Rama Gangula, Fiona James, Natasha Holmes, Effie Mouhtouris, Suman Pakala, Edward Fernandez, Pooja Deshpande, Jason Trubiano, Elizabeth Phillips
Journal: Journal of Allergy and Clinical Immunology (2023)
Conflicting Messages Regarding Infant Feeding May Encourage Delayed Introduction of Potentially Allergenic Foods
Authors: Ashley Fuller, Isha Taneja, Ian Roy, Samantha Yap, Zoe Ongaro, Nicole Randazzo-Ahern, Shelby Scott-Oster, Jane Hubbard, Katherine Darci, Michael Pistiner
Journal: Journal of Allergy and Clinical Immunology (2023)
Patients with eosinophilic esophagitis have a high baseline burden of atopic/allergic comorbidities: from Parts A and B of LIBERTY-EoE-TREET
Authors: Marc Rothenberg, Jonathan Spergel, Evan Dellon, Larry Borish, Xian Sun, Bethany Beazley, Kiran Patel, Arsalan Shabbir
Journal: Journal of Allergy and Clinical Immunology (2023)