tbuckley/cabot-search huggingface dataset:
Interaction Between Frailty and Dementia—Reply
Authors: Thomas M. Gill, Brent Vander Wyk, Robert D. Becher
Journal: JAMA Surgery (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Autonomous social robots are real in the mind's eye of many
Authors: Nathan Caruana, Emily S. Cross
Journal: Behavioral and Brain Sciences (2023)

Abstract Clark and Fischer's dismissal of extant human–robot interaction research approaches limits opportunities to understand major variables shaping people's engagement with social robots. Instead, this endeavour categorically requires multidisciplinary approaches. We refute the assumption that people cannot (correctly or incorrectly) represent robots as autonomous social agents. This contradicts available empirical evidence, and will become increasingly tenuous as robot automation improves.
Association of the Timing and Extent of Cardiac Implantable Electronic Device Infections With Mortality
Authors: Hui-Chen Han, Jia Wang, David H. Birnie, Marco Alings, François Philippon, Ratika Parkash, Jaimie Manlucu, Paul Angaran, Claus Rinne, Benoit Coutu, R. Aaron Low, Vidal Essebag, Carlos Morillo, Jeffrey S. Healey, Damian Redfearn, Satish Toal, Giuliano Becker, Michel DeGrâce, Bernard Thibault, Eugene Crystal, Stanley Tung, John LeMaitre, Omar Sultan, Matthew Bennett, Jamil Bashir, Felix Ayala-Paredes, Philippe Gervais, Leon Rioux, Martin E. W. Hemels, Leon H. R. Bouwels, Derek V. Exner, Paul Dorian, Stuart J. Connolly, Yves Longtin, Andrew D. Krahn
Journal: JAMA Cardiology (2023)

Cardiac implantable electronic device (CIED) infection is a potentially devastating complication with an estimated 12-month mortality of 15% to 30%. The association of the extent (localized or systemic) and timing of infection with all-cause mortality has not been established.
Quantifying Exposure to Wildfire Smoke Among Schoolchildren in California, 2006 to 2021
Authors: Esther E. Velásquez, Tarik Benmarhnia, Joan A. Casey, Rosana Aguilera, Mathew V. Kiang
Journal: JAMA Network Open (2023)

This cross-sectional study quantifies exposure to wildfire particulate matter less than 2.5 μm among schoolchildren in California.
Pulse Wave Amplitude Drops Index: A Biomarker of Cardiovascular Risk in Obstructive Sleep Apnea
Authors: Geoffroy Solelhac, Manuel Sánchez-de-la-Torre, Margaux Blanchard, Mathieu Berger, Camila Hirotsu, Théo Imler, Alicia Sánchez-de-la-Torre, Jose Haba-Rubio, Nicola Andrea Marchi, Virginie Bayon, Sébastien Bailly, François Goupil, Adrien Waeber, Grégory Heiniger, Thierry Pigeanne, Esther Gracia-Lavedan, Andrea Zapater, Jorge Abad, Estrella Ordax, María José Masdeu, Valentin Cabriada-Nuño, Carlos Egea, Sandra Van Den Broecke, Peter Vollenweider, Pedro Marques-Vidal, Julien Vaucher, Giulio Bernardi, Monica Betta, Francesca Siclari, Ferran Barbé, Frédéric Gagnadoux, Raphael Heinzer
Journal: American Journal of Respiratory and Critical Care Medicine (2023)

It is currently unclear which patients with obstructive sleep apnea (OSA) are at increased cardiovascular risk.
Reply: Machine learning models for NAFLD/NASH and cirrhosis diagnosis and staging: accuracy and routine variables are the success keys
Authors: Devon Chang, Emily Truong, Mazen Noureddin
Journal: Hepatology (2023)

1Arnold O. Beckman High School, Irvine, United States 2Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 3Houston Research Institute, Houston Texas Correspondence Mazen Noureddin, Director, Houston Liver Institute, Director, Houston Research Institute, 1155 Dairy Ashford Suite 200, Houston, Texas, 77079. Email: [email protected]
FHL5 Controls Vascular Disease–Associated Gene Programs in Smooth Muscle Cells
Authors: Doris Wong, Gaëlle Auguste, Christian L. Lino Cardenas, Adam W. Turner, Yixuan Chen, Yipei Song, Lijiang Ma, R. Noah Perry, Redouane Aherrahrou, Maniselvan Kuppusamy, Chaojie Yang, Jose Verdezoto Mosquera, Collin J. Dube, Mohammad Daud Khan, Meredith Palmore, Jaspreet Kalra, Maryam Kavousi, Patricia A. Peyser, Ljubica Matic, Ulf Hedin, Ani Manichaikul, Swapnil K. Sonkusare, Mete Civelek, Jason C. Kovacic, Johan L.M. Björkegren, Rajeev Malhotra, Clint L. Miller
Journal: Circulation Research (2023)

Background: Genome-wide association studies have identified hundreds of loci associated with common vascular diseases, such as coronary artery disease, myocardial infarction, and hypertension. However, the lack of mechanistic insights for many GWAS loci limits their translation into the clinic. Among these loci with unknown functions is UFL1 –four-and-a-half LIM (LIN-11, Isl-1, MEC-3) domain 5 ( FHL5 ; chr6q16.1), which reached genome-wide significance in a recent coronary artery disease/ myocardial infarction GWAS meta-analysis. UFL1-FHL5 is also associated with several vascular diseases, consistent with the widespread pleiotropy observed for GWAS loci. Methods: We apply a multimodal approach leveraging statistical fine-mapping, epigenomic profiling, and ex vivo analysis of human coronary artery tissues to implicate FHL5 as the top candidate causal gene. We unravel the molecular mechanisms of the cross-phenotype genetic associations through in vitro functional analyses and epigenomic profiling experiments in coronary artery smooth muscle cells. Results: We prioritized FHL5 as the top candidate causal gene at the UFL1-FHL5 locus through expression quantitative trait locus colocalization methods. FHL5 gene expression was enriched in the smooth muscle cells and pericyte population in human artery tissues with coexpression network analyses supporting a functional role in regulating smooth muscle cell contraction. Unexpectedly, under procalcifying conditions, FHL5 overexpression promoted vascular calcification and dysregulated processes related to extracellular matrix organization and calcium handling. Lastly, by mapping FHL5 binding sites and inferring FHL5 target gene function using artery tissue gene regulatory network analyses, we highlight regulatory interactions between FHL5 and downstream coronary artery disease/myocardial infarction loci, such as FOXL1 and FN1 that have roles in vascular remodeling. Conclusions: Taken together, these studies provide mechanistic insights into the pleiotropic genetic associations of UFL1-FHL5. We show that FHL5 mediates vascular disease risk through transcriptional regulation of downstream vascular remodeling gene programs. These transacting mechanisms may explain a portion of the heritable risk for complex vascular diseases.
Depiction as possible phase in the dynamics of sociomorphing
Authors: Johanna Seibt
Journal: Behavioral and Brain Sciences (2023)

Abstract The depiction model presents a major advance in our theoretical conceptualization of how humans experience and understand social robots. But the scope of the model is, I suggest, more limited: It pertains to one possible phase in a more comprehensive cognitive-practical dynamics of sense-making (“sociomorphing”) as conceptualized in the OASIS framework. According to the OASIS framework, some basic social actions can be realized by robots, while others may be depicted in the way described by the model.
Combined use of nivolumab and ipilimumab in Japanese patients with melanoma: a multicentre retrospective study of 111 cases
Authors: Yasuhiro Fujisawa, Kenjiro Namikawa, Koji Yoshino, Yukiko Kiniwa, Takamichi Ito, Hiroshi Kato, Shigeto Matsushita, Toshihiko Hoashi, Yasuhiro Nakamura, Shusuke Yoshikawa, Takuya Miyagawa, Jun Asai, Taisuke Matsuya, Satoshi Fukushima, Jyunji Kato, Tatsuya Takenouchi, Hiroshi Uchi, Mamiko Masuzawa, Teruki Yanagi, Takeo Maekawa
Journal: British Journal of Dermatology (2023)

In Japanese patients with melanoma, the response rate of nivolumab plus ipilimumab (N/I) was lower than (35.1%) and the rate of adverse events was similar to (60.4%) those reported in previous clinical trials. No survival difference was observed with the use of N/I between clinical types. Patients who achieved a good response had better outcomes. Elevated lactate dehydrogenase level and having three or more metastatic sites were poor prognostic factors.
Two-year physical, mental and cognitive outcomes among intensive care unit survivors treated for COVID-19
Authors: Hidde Heesakkers, Johannes G. van der Hoeven, Mark van den Boogaard, Marieke Zegers, Stijn Corsten, Inge Janssen, Esther Ewalds, Koen S. Simons, Dominique Burgers-Bonthuis, Thijs C. D. Rettig
Journal: Intensive Care Medicine (2023)
Development of an inhalable antiviral powder formulation against respiratory syncytial virus
Authors: Rick Heida, Renate Akkerman, Paulo H. Jacob Silva, Anke J. Lakerveld, Daniel Ortiz, Chiara Bigogno, Matteo Gasbarri, Puck B. van Kasteren, Francesco Stellacci, Henderik W. Frijlink, Anke L.W. Huckriede, Wouter L.J. Hinrichs
Journal: Journal of Controlled Release (2023)

Respiratory viruses including the respiratory syncytial virus (RSV) aggravate the global burden of virus-inflicted morbidity and mortality. Entry inhibitors are a promising class of antiviral drugs for combating these viruses, as they can prevent infection at the site of viral entry, i.e., the respiratory tract. Here we used a broad-spectrum entry inhibitor, composed of a β-cyclodextrin backbone, functionalized with 11-mercapto-1-undecanesulfonate (CD-MUS) that is capable of neutralizing a variety of viruses that employ heparan sulfate proteoglycans (HSPG) to infect host cells. CD-MUS inactivates viral particles irreversibly by binding to viral attachment proteins through a multivalent binding mechanism. In the present study, we show that CD-MUS is well tolerated when administered to the respiratory tract of mice. Based on this, we developed an inhalable spray-dried powder formulation that fits the size requirements for lung deposition and disperses well upon use with the Cyclops dry powder inhaler (DPI). Using an in vitro dose-response assay, we show that the compound retained its activity against RSV after the spray drying process. Our study sets the stage for further in vivo studies, exploring the efficacy of pulmonary administered CD-MUS in animal models of RSV infection.
Secondary Structure in Overcoming Photosensitizers’ Aggregation: <i>α</i>‐Helical Polypeptides for Enhanced Photodynamic Therapy
Authors: Xiang Xu, Jinjuan Ma, Yubin Zheng, Shaolei Wang, Aiguo Wang, Nan Zheng
Journal: Advanced Healthcare Materials (2023)

Abstract Aggregation caused quenching (ACQ) effect can severely inhibit the application of hydrophobic photosensitizers (PSs) bearing planar and rigid structures. Most of the reported cases utilized random‐coiled polymers for the in vivo delivery of PSs, which would inevitably aggravate ACQ effect due to the flexible chains. In this work, the role of polymers’ secondary structures (especially α ‐helical conformation) in overcoming the PSs’ aggregation is systemically investigated based on the design of α ‐helical polypeptides bearing tetraphenylporphyrin (TPP) side chains. Atomistic molecular dynamics simulation, fluorescence quantum yield, and reactive oxygen species (ROS) generation yield are evaluated to demonstrate that α ‐helical polypeptide backbones can significantly boost both fluorescence quantum yield and ROS by suppressing the π ‐ π stacking interaction between TPP units. The enhanced in vitro and in vivo phototoxicity for helical polypeptides also reveal functions of secondary structures in inhibiting ACQ and improving the membrane activity. Successful in vivo photodynamic therapy (PDT) results in mice bearing H22 tumors showed great potentials for further clinical applications.
Error in Variable Conversion in Table
Authors: Crisanto M. Torres, Elliott R. Haut, Joseph V. Sakran
Journal: JAMA Surgery (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
When Pinocchio becomes a real boy: Capability and felicity in AI and interactive depictions
Authors: John M Carroll
Journal: Behavioral and Brain Sciences (2023)

Abstract Clark and Fischer analyze social robots as interactive depictions, presenting characters that people can interact with in social settings. Unlike other types of depictions, the props for social robot depictions depend on emerging interactive technologies. This raises questions about how such depictions depict: They conflate character and prop in ways that delight, confuse, mistreat, and may become ordinary human–technology interactions.
Medication Nonadherence and Risk of Violence to Others Among Patients With Schizophrenia in Western China
Authors: Yang Li, Hong Wen, Chaoxinyu Xiong, Chunying Lin, Xianmei Yang, Dan Wang, Ruoxing Fan, Jun Liu, Xing Zhao, Yuanyuan Liu, Xiang Liu
Journal: JAMA Network Open (2023)

Reducing violence to others in community-based patients with schizophrenia has important implications for public health. Increasing medication adherence is often used to reduce the risk of violence, yet little is known about the association between medication nonadherence and violence to others in this population.To examine the association between medication nonadherence and violence to others among community-based patients with schizophrenia.This large, naturalistic, prospective cohort study was performed in western China from May 1, 2006, to December 31, 2018. The data set was from the integrated management information platform for severe mental disorders. As of December 31, 2018, 292 667 patients with schizophrenia were registered in the platform. During follow-up, patients could enter or leave the cohort at any time. Maximum follow-up was 12.8 years, with a mean (SD) of 4.2 (2.3) years. Data analysis was conducted from July 1, 2021, to September 30, 2022.Medication nonadherence.Violence to others throughout the follow-up period was the outcome, including minor nuisances, violating the Law of the People's Republic of China on Penalties for Administration of Public Security (APS law), and violating criminal law. Information about these behaviors was provided by the public security department. Directed acyclic graphs were used to identify and control confounders. Propensity score matching and generalized linear mixed-effects models were used for analysis.The final study sample included 207 569 patients with schizophrenia. The mean (SD) age was 51.3 (14.5) years, and 107 271 (51.7%) were women; 27 698 (13.3%) perpetrated violence to others, including 22 312 of 142 394 with medication nonadherence (15.7%) and 5386 of 65 175 with adherence (8.3%). In 112 710 propensity score-matched cases, risks of minor nuisances (odds ratio [OR], 1.82 [95% CI, 1.75-1.90]; P < .001), violating APS law (OR, 1.91 [95% CI, 1.78-2.05]; P < .001), and violating criminal law (OR, 1.50 [95% CI, 1.33-1.71]; P < .001) were higher in patients with nonadherence. However, the risk did not increase with higher medication nonadherence. There were differences in risk of violating APS law between urban and rural areas.Medication nonadherence was associated with a higher risk of violence to others among community-based patients with schizophrenia, but the risk did not increase as medication nonadherence increased.
Uptake of tumour necrosis factor-alpha inhibitor biosimilars for psoriasis: a drug utilization study from the British Association of Dermatologists Biologic and Immunomodulators Register (BADBIR)
Authors: Duc Binh Phan, Anthony P Bewley, Catherine H Smith, Teena Mackenzie, Christopher E M Griffiths, Mark Lunt, Richard B Warren, Zenas Z N Yiu
Journal: British Journal of Dermatology (2023)

Tumour necrosis factor-alpha inhibitors (TNFi) have revolutionized the treatment of moderate-to-severe psoriasis. Following patent expiry of the originator biologics, TNFi biosimilars became available, presenting the opportunity for significant reductions in drug costs.To describe the uptake of TNFi biosimilars for psoriasis treatment in the UK and Ireland.This observational cohort study utilizes data from the British Association of Dermatologists Biologic and Immunomodulators Register (BADBIR), a national pharmacovigilance study register for patients with psoriasis on systemic treatments. We analysed biosimilar uptake trends over time in nine geographical regions of England along with Wales, Scotland, Northern Ireland and the Republic of Ireland. We assessed the incidence of switching to biosimilars in an originator-user cohort (switchers). Patients on originators infliximab, etanercept and adalimumab at the time originator patents expired, entered the cohort on 1 February 2015, August 2015 and October 2018, respectively, and were followed up until 31 October 2021. Trends in biosimilar initiations were assessed in an adalimumab-naïve cohort who started adalimumab between 1 October 2018 and 31 July 2019 (starters). We assessed the associations between patient factors and originator-to-biosimilar switching and biosimilar initiation using a multivariable Cox regression model and a multivariable logistic regression model, respectively.Included in the originator-user cohort were 4202 patients (209 on infliximab, 742 on etanercept and 3251 on adalimumab). For infliximab, etanercept and adalimumab, respectively, the cumulative incidence of originator-to-biosimilar switching increased with time to 14.8%, 23.6% and 66.6% after 3 years. Across geographical regions, 3-year switching rates varied from 0% to 43.7% for infliximab; from 0% to 40.4% for etanercept; and from 12.5% to 84.3% for adalimumab. Out of the 528 patients included in the adalimumab-naïve cohort, 67.8% started on biosimilars. Originator-to-biosimilar switching and biosimilar initiation were more common in men and in patients who had lower Psoriasis Area and Severity Index at cohort entry.The uptake of biosimilars increased over time and varied considerably across the UK and Ireland; adalimumab had the highest biosimilar uptake rate compared with that of other TNFi drugs.
A more ecological perspective on human–robot interactions
Authors: Varun Ravikumar, Jonathan Bowen, Michael L Anderson
Journal: Behavioral and Brain Sciences (2023)

Abstract Drawing from two strands of ecological psychology, we suggest that even if social robots are interactive depictions, people need not mentally represent them as such. Rather, people can engage with the opportunities for action or affordances that social robots offer to them. These affordances are constrained by the larger sociocultural settings within which human–robot interactions occur.
Acknowledging Lack of Inclusion in Genetic Analyses
Authors: Vani Pariyadath
Journal: JAMA Psychiatry (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Modeling Future Estimated Glomerular Filtration Rate in Patients With Diabetes—Are There Risks to Early Risk Stratification?
Authors: Sarah F. Sanghavi
Journal: JAMA Network Open (2023)

Mariella Gregorich, MS; Michael Kammer, PhD; Andreas Heinzel, MS; Carsten Böger, MD; Kai-Uwe Eckardt, MD; Hiddo Lambers Heerspink, PhD; Bettina Jung, MD; Gert Mayer, MD; Heike Meiselbach, MD; Matthias Schmid, PhD; Ulla T. Schultheiss, MD; Georg Heinze, PhD; Rainer Oberbauer, PhD; BEAt-DKD Consortium
Estimated Therapy Costs and Downstream Cost Consequences of iBASIS–Video Interaction to Promote Positive Parenting Intervention vs Usual Care Among Children Displaying Early Behavioral Signs of Autism in Australia
Authors: Leonie Segal, Jonathan Green, Asterie Twizeyemariya, Kristelle Hudry, Ming Wai Wan, Josephine Barbaro, Teresa Iacono, Kandice J. Varcin, Sarah Pillar, Matthew N. Cooper, Wesley Billingham, Gemma Upson, Andrew J. O. Whitehouse
Journal: JAMA Network Open (2023)

The growing global prevalence of autism spectrum disorder (ASD) is associated with increasing costs for support services. Ascertaining the effects of a successful preemptive intervention for infants showing early behavioral signs of autism on human services budgets is highly policy relevant.
Dancing robots: Social interactions are performed, not depicted
Authors: Guido Orgs, Emily S. Cross
Journal: Behavioral and Brain Sciences (2023)

Abstract Clark and Fischer's depiction hypothesis is based on examples of western mimetic art. Yet social robots do not depict social interactions, but instead perform them. Similarly, dance and performance art do not rely on depiction. Kinematics and expressivity are better predictors of dance aesthetics and of effective social interactions. In this way, social robots are more like dancers than actors.