tbuckley/cabot-search huggingface dataset:
Discovery of deoxyandrographolide and its novel effect on vascular senescence by targeting HDAC1
Authors: Zhongxiao Lin, Hao He, Yu Xian, Jianghong Cai, Qinyang Ge, Minghao Guo, Quan Zheng, Xiaoyan Liu, Chengke Mo, Xin Zhang, Wei Qi, Youming Zhang, Lu Liang, Xi‐Yong Yu, Yi Zhun Zhu
Journal: MedComm (2023)

Aconitum carmichaelii (Fuzi) is a traditional Chinese medicine that has been widely used in the clinic to save the dying life for over several thousand years. However, the medicinal components of Fuzi in treating vascular senescence (VS) and its potential mechanism remain unclear. In this study, a network pharmacology method was used to explore the possible components and further validated by experiments to get a candidate compound, deoxyandrographolide (DA). DA restrains aging biomarkers, such as p16, p21, γH2A.X, and p53 in vitro and in vivo blood co-culture studies. Histone deacetylase 1 (HDAC1), mouse double minute2 (MDM2), cyclin-dependent kinase 4, and mechanistic target of rapamycin kinase (mTOR) are predicted to be the possible targets of DA based on virtual screening. Subsequent bio-layer interferometry results indicated that DA showed good affinity capability with HDAC1. DA enhances the protein expression of HDAC1 in the angiotensin II-induced senescence process by inhibiting its ubiquitination degradation. Loss of HDAC1 by CRISPR/Cas9 leads to the disappearance of DA's anti-aging property. The enhancement of HDAC1 represses H3K4me3 (a biomarker of chromosomal activity) and improves chromosome stability. RNA sequencing results also confirmed our hypothesis. Our evidence illuminated that DA may achieve as a novel compound in the treatment of VS by improving chromosome stability.
Recanalization by magnetic compression anastomosis for complete bile duct obstruction and retrieval of a migrated magnet
Authors: Ikuhiro Kobori, Takuji Noro, Musashi Takada, Koichi Soga, Masaya Tamano, Hideyuki Yoshitomi, Eigoro Yamanouchi
Journal: Endoscopy (2023)

Complete obstruction of the bile duct after hepatic resection is rare and extremely difficult to treat. We report recanalization using magnetic compression anastomosis and retrieval of a magnet that migrated into the intrahepatic bile duct.
Non-animal endoscopic training models are also effective for simulation of endoscopic submucosal dissection with adaptive traction strategy
Authors: Elena De Cristofaro, Pierre Lafeuille, Jérémie Jacques, Louis-Jean Masgnaux, Timothée Wallenhorst, Clara Yzet, Mathieu Pioche
Journal: Endoscopy (2023)

EndoGel (Fujifilm, Tokyo, Japan) is a new non-animal training model for endoscopic submucosal dissection (ESD) that seems a good option for initial training. The European Society of Gastrointestinal Endoscopy developed an ESD curriculum recommending at least 20 simulated ESD procedures on animal and/or ex vivo models before human practice. However, this training strategy creates ethical, ecological, and economical challenges (e. g. need for dedicated scopes, devices, and rooms). Additionally, there is a low but non-negligible risk of cross contamination.
‘Clip with Line Pulley Securing’ Technique using Modified Anchoring Clip for Mucosal Defect Closure
Authors: Darshan Parekh, Yohei Minato, Nao Takeuchi, Shunya Takayanagi, Marina Kim, Suryaprakash Bhandari, Ken Ohata
Journal: Endoscopy (2023)

Mucosal closure techniques are the backbone of interventional endoscopy, requiring focused and dedicated development. We present a novel closure technique that is easily applicable, economical, and effective for large mucosal defects.
Application of radiofrequency ablation in duodenal mucosal reconstruction
Authors: Zhengqi Li, Biao Zhou, Nianrong Zhang, Siqi Wang, Hua Meng
Journal: Endoscopy (2023)

A 63-year-old woman was diagnosed with type 2 diabetes 8 months ago and was scheduled for duodenal mucosal reconstruction. The patient took metformin orally to control blood sugar. Before the operation, fasting blood glucose was 7.0 mmol/L (15.7 mmol/L 2 hours after a meal), and glycosylated hemoglobin was 7.1 %. A single-channel flexible endoscope (EVIS GIF-N170; Olympus, Tokyo, Japan) was introduced into the horizontal part of the duodenum, and the Endoscopic Catheter (Barrx Channel; Medtronic, Minneapolis, USA) was inserted into the biopsy channel of the endoscope ([Fig. 1]). Radiofrequency ablation of the duodenal mucosa was performed, starting from the horizontal part of the duodenum, while the endoscope was gradually withdrawn ([Fig. 2]). By rotating the endoscope and the catheter, all four quadrants of the duodenal mucosa were ablated ([Fig. 3]). Overall, a 13-cm length of duodenal mucosa was ablated without bleeding or perforation ([Fig. 4], [Video 1]).
Sliding tube-assisted ERCP in a patient who underwent double tract reconstruction anatomy after proximal gastrectomy
Authors: Koichiro Kawano, Mamoru Takenaka, Reiko Kawano, Takao Katoh, Katsuhisa Nishi, Chang-Il Kwon, Masatoshi Kudo
Journal: Endoscopy (2023)

For patients with surgically altered gastrointestinal anatomy, the difficulty of performing endoscopic retrograde cholangiopancreatography (ERCP) has been reported [1] [2] [3]. After proximal gastrectomy, double tract reconstruction is usually performed (PG-DT), and some patients with PG-DT require ERCP. Although a technique of guidewire-assisted side-viewing scope insertion for patients with PG-DT has been reported [4], the bent and tortuous nature of the interstitial jejunum and the end-to-side anastomosis of the gastric jejunum make it difficult ([Fig. 1]).
Endoscopic closure of a rectal fistula using a cardiac septal defect occluder: the final redemption
Authors: Renato Medas, Eduardo Rodrigues-Pinto, João Carlos Silva, Pedro Pereira, Guilherme Macedo
Journal: Endoscopy (2023)

An 84-year-old man with medical history of T1 bladder cancer underwent radical cystectomy, with subsequent complication of surgical site abscess. Abdominal computed tomography revealed free gas at the surgical site and a rectal wall defect suggestive of fistula. Despite conservative treatment, the patient had persistent penial and anal discharge and was referred for endoscopic closure.
Microscopic alterations of the gastric mucosa in preneoplastic lesions as assessed by new-generation endocytoscopy
Authors: Riccardo Vasapolli, Lukas Neuhaus, Jörg Schirra, Jens Neumann, Julia Mayerle, Peter Malfertheiner, Christian Schulz
Journal: Endoscopy (2023)

Chronic atrophic gastritis with/without intestinal metaplasia is defined as a gastric precancerous condition (GPC) that increases the risk of gastric cancer according to the severity of atrophy [1]. Advanced endoscopic imaging permits accurate visualization of the mucosa and optical diagnosis of GPC [2]. Endocytoscopy introduces a further step, providing ultrahigh magnification images and in vivo histologic assessment of nuclear and cellular structures; however, data on endocytoscopic characterization of GPC are lacking [3].
Full-thickness defect closure using the reopenable clip over-the-line method with omental patch
Authors: Tatsuma Nomura, Shinya Sugimoto, Yu Fujimura, Keiichi Ito, Yasuo Katsumine, Noriya Uedo
Journal: Endoscopy (2023)

Various endoscopic defect closure methods following endoscopic full-thickness resection (EFTR) of submucosal tumors have been developed [1] [2]; however, there is no established endoscopic defect closure method that can close a full-thickness defect as reliably as surgical suturing. We developed the reopenable clip-over-line method (ROLM), capable of closure of large mucosal defects and defect closure post-EFTR [3] [4]. Here, we report the use of the ROLM with an omental patch (ROLM-OP), which includes closure of the serosal muscle layer using omental fat ([Video 1]).
Endoscopic intermuscular dissection in the management of a rectal neuroendocrine tumor
Authors: Suhuan Liao, Bo Li, Longbin Huang, Qiuping Qiu, Guang Yang, Jianzhen Ren, Silin Huang
Journal: Endoscopy (2023)

A 49-year-old man was admitted to our hospital for endoscopic resection of a subepithelial lesion located in the lower rectum ([Fig. 1 a]). The lesion was incidentally discovered during routine screening colonoscopy. Endoscopic ultrasound confirmed that the lesion originated from the submucosal layer ([Fig. 1 b]). Positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro-D-glucose/computed tomography + speckle reduction imaging (18F-FDG PET/CT + SRI) suggested that the lesion was a neuroendocrine tumor (NET) with high expression of growth inhibitor receptors, without evidence of lymphatic or organ metastasis ([Fig. 2]). The possibility of endoscopic resection was discussed with the patient, and subsequently, endoscopic intermuscular dissection (EID) was performed ([Video 1]).
Successful troubleshooting for “stone-basket impaction” using argon plasma coagulation and a novel device delivery system
Authors: Koichiro Mandai, Hiroaki Satake, Takato Inoue
Journal: Endoscopy (2023)

Various techniques, including the use of a transoral endotripter, extracorporeal shock wave lithotripsy, and electrohydraulic lithotripsy (EHL), have been reported to resolve basket catheter impaction [1]. Additionally, argon plasma coagulation (APC) may be effective in cutting metal wires [2]. We describe a successful troubleshooting method to resolve stone-basket impaction that is achieved by cutting the basket wires using APC and removing them via a novel device delivery system.
Successful closure of a refractory gastrobronchial fistula using endoscopic mucosal ablation followed by single loop-and-clips technique
Authors: Sandra Maisterra, Sergi Quintana-Carbo, Humberto Aranda, Mariona Calvo, Leandre Farran, Nuria Virgili, Joan B. Gornals
Journal: Endoscopy (2023)

A 78-year-old man developed a late fistula between the gastroplasty pouch and right bronchus following Ivor Lewis esophagectomy for esophageal neoplasia ([Fig. 1]). He was unable to ingest food orally, necessitating the placement of a permanent percutaneous jejunostomy. He had a persistent cough, and the fistula was refractory to various endoscopic interventions, including placement of clips, tissue adhesives, and stents.
Saline-tunneling endoscopic intermuscular dissection for the removal of rectal cancer using the hydrodissection method
Authors: Felipe Ramos-Zabala, Francisco J. Pérez-Rodríguez, Alejandra Alzina-Pérez, Marian García-Mayor, Luis Moreno-Almazán
Journal: Endoscopy (2023)

A 67-year-old man was referred for consideration of endoscopic versus surgical resection of a rectal polyp after macroscopic suspicion of malignancy on screening colonoscopy. The procedure showed a 25-mm Paris Is + IIc lesion located 3 cm above the dentate line. Within the depression a clearly demarcated area was identified with a distorted pit pattern and irregular vascular pattern ([Fig. 1]). Staging of the rectal lesion by magnetic resonance imaging and endoscopic ultrasound showed cT1–2N0M0 and uT1N0, respectively. A multidisciplinary decision was taken to proceed with endoscopic intermuscular dissection (EID) [1] for endoscopic local staging and possible definitive management.
Novel technique of cholangioscopy-guided inwardly migrated stent retrieval
Authors: Rami Reddy Yalaka, G. S. Sameer Kumar, Kondal Reddy Mogili, Chandan Kumar Kedarisetty, Raghavendra Babu Yalakanti
Journal: Endoscopy (2023)

We present a case of a 54-year-old man who had undergone a liver transplant and developed a biliary anastomotic stricture. The patient underwent endoscopic retrograde cholangiopancreatography (ERCP) and stenting for the treatment of the condition. He visited our facility for a stent exchange. During the ERCP procedure, it was discovered that one of the stents had migrated inward ([Fig. 1]). Despite multiple attempts using the biliary balloon, basket, and snare for stent extraction, all efforts were unsuccessful [1] [2] [3] [4]. Consequently, we decided to perform cholangioscopy (SpyGlass DS; Boston Scientific, Marlborough, Massachusetts, USA), which revealed that the distal end of the stent was lodged in the wall of the distal common bile duct ([Video 1]). However, the deep impaction made it impossible to employ the spy snare. Therefore, we opted to disimpact the stent [5].
Multiple switching between the biosimilar adalimumab PF-06410293 and reference adalimumab in patients with active rheumatoid arthritis: a phase 3, open-label, randomised, parallel-group study
Authors: Roy M Fleischmann, Wassim Saikali, Sharad Lakhanpal, Daniel F Alvarez, Donna S Cox, Claudia Ana Ianos, Wuyan Zhang, Carol Cronenberger, Karen Wang
Journal: The Lancet Rheumatology (2023)
“Tip-in underwater endoscopic mucosal resection” without submucosal injection for superficial nonampullary duodenal adenomas
Authors: Koichi Okamoto, Tomoyuki Kawaguchi, Kaizo Kagemoto, Yoshifumi Kida, Yasuhiro Mitsui, Yasushi Sato, Tetsuji Takayama
Journal: Endoscopy (2023)

Underwater endoscopic mucosal resection (EMR) has been reported as an effective treatment for superficial nonampullary duodenal adenomas [1] [2]. However, the en bloc and R0 resection rates have been relatively low [3], possibly because the floating center of the lesion can hinder the visualization of its distal edge. This can cause the snare tip to slip, making it difficult to capture the lesion and achieve en bloc resection. To overcome these challenges, we report our new technique of "tip-in underwater EMR" for superficial nonampullary duodenal adenomas.
Peroral endoscopic myotomy for Zenker’s diverticulum without tunneling
Authors: Georgios Mavrogenis, Fateh Bazerbachi
Journal: Endoscopy (2023)

Peroral endoscopic myotomy (POEM) is an increasingly adopted strategy for the treatment of Zenker's diverticulum ([Fig. 1]). The Z-POEM technique allows for a deep incision of the cricopharyngeal muscle up to its transition to the esophageal muscle layer, and therefore more complete myotomy than direct diverticulotomy. Several modifications of the standard technique have been demonstrated [1] [2] [3]. The mucosal incision is most commonly performed over the septum, and two tunnels are created along the cricopharyngeal muscle. Next, the muscle is transected. Recently, we have described a variation of this technique with the creation of a single tunnel instead of two, to shorten the duration of the procedure [3]. However, we have now shifted to a novel approach that obviates the need for double or single tunneling ([Video 1]).
Endoscopic ultrasound-guided radiofrequency ablation for solid pseudopapillary neoplasm of the pancreas
Authors: Antoine Coupier, Tawfik Khoury, Rodica Gincul, Fabien Fumex, Andrea Lisotti, Sarah Leblanc, Bertrand Napoléon
Journal: Endoscopy (2023)

A solid pseudopapillary neoplasm (SPN) is considered a low-grade malignant neoplasm, more often composed of both solid and cystic components with pseudopapillary areas but predominantly solid in 15 % of cases [1]. It is estimated to account for 1 % to 3 % of all pancreatic tumors [2]. Immunostaining of SPNs for beta-catenin is specific [3]. The natural history of these lesions is unknown, but the malignant potential is demonstrated especially in large lesions. The gold standard therapy is surgical resection. Nonetheless, an alternative such as endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA), which is less invasive [4], should be discussed, especially for young patients with small lesions [5]. All cases of SPN seen and treated with EUS-RFA between 2018 and 2020 were reviewed (IRB 00010835).
Initial training in cold snare polypectomy for residents using a new training model
Authors: Hiroki Kato, Makoto Kobayashi, Motoyoshi Yano
Journal: Endoscopy (2023)

We have previously reported that the use of the Endoscopist & Assistant's Simulator drY lab (EASY; Tanac Co. Ltd., Gifu, Japan) ([Fig. 1]) was useful in recruiting residents [1]. The version of EASY described in this report (EASY CSP) is an endoscopic simulator for resection by snare and clip closure developed by Matsuzaki and Tsunemi ([Fig. 2]). The procedure can be practiced on the device, which has been developed for training in polypectomy and suturing techniques. It allows for easy training with simple set up.
Combined laparoscopic–endoscopic resection of a bleeding giant duodenal Brunner’s gland hamartoma
Authors: Alessandra Marano, Marco Sacco, Lisa Marie Rorato, Stefania Caronna, Fabrizia Di Giovanni, Mauro Santarelli, Claudio Giovanni De Angelis
Journal: Endoscopy (2023)

Brunner's gland hamartoma is a rare entity and constitutes 10.6 % of all benign duodenal tumors [1]. In symptomatic patients, endoscopy represents the first-line treatment; however, there are many technical challenges that can limit endoscopic removal, including the size and location of the lesion. Therefore, surgery may be required for complex cases [2] [3].
Novel motorized spiral enteroscopy-assisted ERCP in a case of surgically altered anatomy
Authors: Awanish Tewari, Vikram Uttam Patil, Mahesh Kumar Goenka
Journal: Endoscopy (2023)

Endoscopic retrograde cholangiopancreatography (ERCP) in patients with surgically altered anatomy is intrinsically challenging [1]. Pooled rates of technical success, clinical success, and adverse events with balloon-assisted ERCP are reported to be 71.4 %, 58.7 %, and 8.4 %, respectively [2]. We report a case where we successfully performed novel motorized spiral enteroscopy (NMSE)-assisted ERCP in a patient with surgically altered anatomy.
Are giant Brunner’s gland hyperplasia and gastric heterotopia unknown complications of Roux-en-Y gastric bypass?
Authors: Clara Yzet, Pierre Lafeuille, Elise Pelascini, Jérôme Rivory, Valérie Hervieu, Mathieu Pioche
Journal: Endoscopy (2023)

The exploration of the excluded duodenum is challenging after a Roux-en-Y gastric bypass (RYGB). Endoscopic ultrasound (EUS)-directed endoscopic retrograde cholangiopancreatography (EDGE) is an emerging endoscopic method that allows examination of the duodenum after placement of an apposition stent [1].
Usefulness of the artificial intelligence-mediated virtual chromoendoscopy in peroral cholangioscopy
Authors: Ryosuke Sato, Kazuyuki Matsumoto, Hideaki Kinugasa, Daisuke Uchida, Shigeru Horiguchi, Hironari Kato, Motoyuki Otsuka
Journal: Endoscopy (2023)

Chromoendoscopy is mainly used in gastrointestinal endoscopy to enhance the visibility of mucosal abnormalities in the digestive tract, by applying stains to the mucosa during endoscopy. The most commonly used stain in chromoendoscopy is indigo carmine, which can highlight subtle changes when sprayed onto the mucosa. Indigo carmine staining is also expected to be useful for the diagnosis of biliary diseases on peroral cholangioscopy (POCS). However, because the bile duct lumen is usually filled with bile or saline during POCS, it is difficult to spray the indigo carmine. In addition, the safety of spraying indigo carmine in the bile duct is unclear.
Multipolar adaptive traction makes endoscopic submucosal dissection feasible for large neoplastic area of the fundus in patient with familial adenomatous polyposis
Authors: Elena de Cristofaro, Louis-Jean Masgnaux, Jean-Christophe Saurin, Jérémie Jacques, Bertrand Napoléon, Jérôme Rivory, Mathieu Pioche
Journal: Endoscopy (2023)

Multiple fundic gland polyps (FGPs) are often found in patients with familial adenomatous polyposis (FAP) but are usually benign. FAP-associated dysplasia is rare but, where found, is fundic, whitish, and flat [1]. Endoscopic submucosal dissection (ESD) is a good but challenging option for achieving complete resection because the top of the fundus is difficult to reach and because the multiple FGPs obscure the margins of the dysplastic area, making incision difficult. Dedicated scopes such as the double bending therapeutic gastroscope (2TQ260M; Olympus, Tokyo, Japan) have been designed for fundic lesions, but are not available in Europe [2]. Therefore, alternative strategies are much needed. Adaptive traction devices are useful for complex lesions [3] [4] [5]. We describe an option for ESD of difficult fundic lesions using the 4-point multipolar adaptive traction device (A-TRACT 4).
A novel ultrathin cholangioscope for endoscopic ultrasound-guided antegrade intervention in patients with Roux-en-Y hepaticojejunostomy
Authors: Tadahisa Inoue, Rena Kitano, Mayu Ibusuki, Yuji Kobayashi, Kiyoaki Ito, Masashi Yoneda
Journal: Endoscopy (2023)

Cholangitis can occur after biliary reconstructive surgery and is most commonly caused by hepaticojejunostomy anastomotic strictures and bile duct stones [1]. Endoscopic ultrasound-guided antegrade treatment (EUS-AG) has recently been performed in cases where balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography (BE-ERCP) is difficult [2]. In EUS-AG, cholangioscopy is needed to obtain direct visual information on the anastomosis. However, it is often difficult to insert a cholangioscope in a significantly dilated fistula due to the narrowness of the intrahepatic bile ducts. We report the feasibility of a novel ultrathin cholangioscope (DRES Slim Scope; Japan Lifeline Co., Ltd., Tokyo, Japan) that has almost the same diameter as a standard ERCP catheter ([Fig. 1]).
Use of a novel clip-band device for difficult biliary cannulation due to papillary edema after precutting
Authors: Koichiro Mandai, Tomoya Ogawa
Journal: Endoscopy (2023)

Duodenoscopic clipping is often challenging because the duodenoscope elevator may disrupt the opening and rotation of the clip. However, the SureClip (Micro-Tech Co. Ltd., Nanjing, China), which provides enhanced rotational and re-opening performance, facilitates easier clipping while using a duodenoscope [1]. Recently, a novel clip-band device called the SureClip Traction Band (Micro-Tech Co. Ltd.) was developed and reported to be a useful traction device for endoscopic submucosal dissection [2]. The device consists of the SureClip and an elastic silicone band. Here, we describe the use of a novel clip-band device for difficult biliary cannulation due to significant edema of the major papilla after pre-cutting.
Gel immersion endoscopic mucosal resection for pedunculated Brunner’s gland hyperplasia in the duodenal bulb near the pylorus
Authors: Chihiro Goto, Kenichiro Okimoto, Tomoaki Matsumura, Naoki Akizue, Keisuke Matsusaka, Jun Kato, Naoya Kato
Journal: Endoscopy (2023)

Brunner's gland hyperplasia is a benign tumor that occurs primarily in the duodenal bulb. Endoscopic resection is indicated when there is bleeding, obstructive symptoms, or the lesion is large and malignancy cannot be ruled out [1]. Conventional endoscopic mucosal resection (EMR) for the resection of Brunner's gland hyperplasia has been reported [2] [3]. However, conventional EMR of large Burner's gland hyperplasia in the duodenal bulb is often difficult because the space is narrowed by local injection, reducing visibility and maneuverability. Underwater EMR may be an effective method [4], but it is often difficult to secure the visual field owing to poor saline retention in the duodenal bulb near the pylorus. Gel immersion EMR (GI-EMR) has recently been reported for duodenal tumors [5]. Here we report the usefulness of GI-EMR in the duodenal bulb near the pylorus for pedunculated Brunner's gland hyperplasia.
Hemostasis of small-intestinal diverticular bleeding with the over-the-scope clip method
Authors: Hiroshi Tanabe, Koichiro Kawano, Reiko Kawano, Takao Katoh, Katsuhisa Nishi, Yoriaki Komeda, Mamoru Takenaka
Journal: Endoscopy (2023)

Effective endoscopic hemostatic techniques for small-intestinal diverticular bleeding have not been established. While endoscopic band ligation (EBL) is reported to be effective for colonic diverticular hemorrhage, it has been reported to cause delayed perforation owing to a completely occluded ligature site and necrosis ([Fig. 1]) [1]. Reports of EBL in the small intestine suggest that the risk of perforation may be high because the ligature site is often ligated down to the serosa [2]. Therefore, a safe and effective hemostatic method for small-intestinal diverticular bleeding is required. It has been reported that application of an over-the-scope (OTS) clip ([Fig. 2]) can be useful for colonic diverticular hemorrhage [3] [4], but there have been no reports of their use for small-bowel diverticular bleeding.