tbuckley/cabot-search huggingface dataset:
Medicare Cuts Still Uncertain
Authors: Brian Vastag
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Senility Reconsidered
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vasculitis attributed to the nicotine patch (Nicotinell)
Authors: M.M. VAN DER KLAUW, E. VAN HILLO, W.H.H.W. VAN DEN BERG, E.P.M. BOLSIUS, F.F.J.M. SUTORIUS, B.H.C. STRICKER
Journal: British Journal of Dermatology (1996)
Morning Glory
Authors: Martha Harwit
Journal: Annals of Internal Medicine (1992)

Ad Libitum1 August 1992Morning GloryMartha Harwit, MDMartha Harwit, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-3-262 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptYour blue petals open and reflect in them the splendor of the sky the brilliance of the sun on a perfect June morning.The breeze is light scented with dogwood myrtle and honeysuckle; the symphony of color and light and air begins.Your melodious charm brings me out today to share your rejoicing your whispers of thanks for the glory of this morning.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1992Volume 117, Issue 3Page: 262-262 ePublished: 1 December 2008 Issue Published: 1 August 1992 PDF downloadLoading ...
Theophylline improves acute mountain sickness
Authors: R. Fischer, S.M. Lang, U. Steiner, M. Toepfer, H. Hautmann, H. Pongratz, R.M. Huber
Journal: European Respiratory Journal (2000)

<b>Background:</b> Recent cytogenetic studies have shown that reciprocal translocation t (17;22)(q22;q13) and a supernumerary ring chromosome derived from the translocation r(17;22) are highly characteristic of dermatofibrosarcoma protuberans (DFSP). The chromosomal rearrangements fuse the collagen type Iα1 (COL1A1) and the platelet-derived growth factor B-chain (PDGFB) genes. The COL1A1–PDGFB fusion transcript has been shown not only in conventional DFSP but also in a small series of DFSP with fibrosarcomatons areas (DFSP-FS) using reverse transcriptase-based conventional polymerase chain reaction. Nothing is known about the status of the COL1A1–PDGFB chimaeric gene in the pleomorphic areas of DFSP-PleoSarc (formerly known as DFSP-malignant fibrous sarcoma). <b>Aims:</b> To show the COL1A1–PDGFB fusion transcript in transformed malignant fibrous histiocytoma. <b>Method:</b> A real-time polymerase chain reaction assay for the COL1A1–PDGFB fusion transcript in a series of DFSP containing sarcoma was conducted to determine whether the chimaeric gene could be identified in both components of DFSP-FS and DFSP-PleoSarc. Eight cases were analysed. <b>Results:</b> In seven cases, transcriptable RNA was detected, and in these cases, translocations were found between COL1A1 and PDGFB genes involving exons 27, 32, 34, 40 and 47 of the COL1A1 gene and exon 2 of the PDGFB gene. <b>Conclusions:</b> From a diagnostic aspect, this assay can be particularly useful in confirming the diagnosis of sarcomatous DFSP. On the other hand, the COL1A1–PDGFB fusion gene was shown in three cases of DFSP containing pleomorphic sarcoma, which supports the theory of the common histogenesis.
<i>QuickStats:</i>Colorectal Cancer Screening* Among Adults Aged 50–75 Years, by Race/Ethnicity<sup>†</sup>— National Health Interview Survey,<sup>§</sup>United States, 2000–2015
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

During 2000-2015, among adults aged 50-75 years, the use of colorectal cancer tests or procedures increased for all racial/ ethnic groups included in the analysis. Colorectal screening percentages more than doubled for non-Hispanic black, Hispanic, and non-Hispanic Asian adults during that period. Despite these increases, in 2015, the prevalence of colorectal cancer screening was higher among non-Hispanic white (65.6%) adults than among non-Hispanic black (60.3%), non-Hispanic Asian (52.1%), and Hispanic (47.4%) adults.
THE PLAGUE IN CHINA.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manuscripts Approved for JNCI, October-November 1971
Journal: JNCI Journal of the National Cancer Institute (1971)

Manuscripts Approved for JNCI, October-November 1971 Get access JNCI: Journal of the National Cancer Institute, Volume 47, Issue 6, December 1971, Pages 1407–1408, https://doi.org/10.1093/jnci/47.6.1407-a Published: 01 December 1971
Underdiagnosis of Dengue—Laredo, Texas, 1999
Journal: JAMA (2001)

Dengue outbreaks have been reported in communities along the Mexico-U.S. border since 1980; however, during 1987-July 1999, no cases were reported from Laredo, Texas (1999 population: 162,000). During January-July 1999, approximately 300-325 dengue cases were reported from Nuevo Laredo, Tamaulipas, Mexico (1999 population: 274,000), a city across the Rio Grande from Laredo. To determine whether undiagnosed or unreported dengue cases had occurred in Laredo, the Texas Department of Health (TDH) reviewed medical records from five Laredo health facilities (the two city hospitals and the three largest of five community clinics). This report summarizes the findings of the review, which indicated that during July 23-August 20, 1999, 50% of suspected case-patients had undiagnosed dengue infection. Recognition of the diagnosis of dengue can be improved through heightened surveillance, professional and public education, and prompt reporting of cases by the health-care providers to local or state health departments.
Alterations in G-protein-regulated transmembrane signalling induced in murine myocardium by coxsackievirus B3 infection
Authors: J. Novotny, P. Kvapil, F. Jelinek, L. A. Ransnas
Journal: Cardiovascular Research (1995)

Objective: Cardiomyopathy is usually associated with marked alterations in myocardial transmembrane signalling. Although acute viral myocarditis may result in chronic cardiomyopathy in some cases, the possible consequences of viral infection on function of the myocardial signal-transducing complex have not been explored. Therefore, the present study was designed to investigated the G-protein-regulated adenylyl cyclase signalling system in murine myocardium during myocarditis induced by coxsackievirus B3 (CVB3) infection. Methods: We examined the functional characteristics of adenylyl cyclase as well as the function and distribution of β-adrenoceptors, m-cholinoceptors and G-proteins in myocardial plasma membranes isolated from the hearts of mice with acute (7 days pi) or late phase (21 days pi) myocarditis and the obtained results were compared with the corresponding data determined in age-matched controls. Results: While the basal adenylyl cyclase activity was not significantly altered, the ability of forskolin, sodium fluoride and GTPγS to activate adenylyl cyclase was lowered by about 20% in samples from virus-infected animals. The level of Gsα in myocardial plasma membranes as well as the functional activity of Gsα was not affected by viral infection, but the Giα content was increased by about 20%. The total number of β-adrenoceptors in myocardial plasma membranes increased by about 12–15% due to higher content of the β2-adrenoceptor subtype. Although the agonist-binding parameters of β-adrenoceptors were not significantly altered, the ability of these receptors to mediate stimulation of adenylate cyclase was markedly diminished (by 56–80%). The total number of m-cholinoceptors in samples derived from virus-infected mice increased considerably (by 29–59%) and a significant proportion of the receptors shifted to a higher affinity status, but their ability to transduce agonist signals was impaired. Conclusions: These data are the first to demonstrate that several different sites of the myocardial G-protein-regulated adenylyl cyclase signalling complex are significantly altered in acute as well as in late phase of CVB3-induced myocarditis.
Highlights
Journal: JAMA (2019)

Effect of bempedoic acid on low-density lipoprotein cholesterol (LDL-C) level Bempedoic acid PlaceboClinical guidelines recommend that patients with atherosclerotic cardiovascular disease (ASCVD) who do not achieve suffi cient reductions in low-density lipoprotein cholesterol (LDL-C) with statin therapy should also be treated with nonstatin agents.Goldberg and colleagues randomized 779 patients with ASCVD or familial hypercholesterolemia who were receiving maximally tolerated statins and found that the addition of bempedoic acid resulted in a signifi cant lowering of LDL-C over 12 weeks.In an Editorial, Honigberg and Natarajan note that clinical guidelines have endorsed stringent LDL-C reduction for patients at high risk for ASCVD.
Neonatal Asphyxia
Authors: J. B. Joyce
Journal: BMJ (1953)

<h3>Abstract</h3> <h3>objectives</h3> to assess the prevalence of COVID-19 (PCR-test) in residents and staff of a nursing home. To examine the presence of IgM and IgG antibodies in the sample and the relation between PCR and antibody test results. <h3>design</h3> cross-sectional and (retrospective) cohort study <h3>setting</h3> a nursing home for the elderly Bessemerberg in Lanaken (Belgium) with up to 130 beds. Lanaken is situated in the Belgian province with the highest COVID-19 prevalence. <h3>participants</h3> residents (N=108) and staff members (N=93) of the nursing home <h3>outcomes</h3> PCR, IgM and IgG <h3>results</h3> the prevalence of COVID-19, based on PCR test was 34% (N=40) for residents and 13% (N=11) for staff members, respectively. Of the residents, 13% showed positive IgM results and 15% positive IgG results. In 17% of the residents, at least one of the antibodies was positive. In total 13% of the staff members had positive IgM and 16% had a positive IgG. In 20% of the staff members at least one of these antibody tests was positive. In PCR positive residents, the percentage of IgM positive, IgG positive, and at least one of both was 28%, 34%, and 41%. In PCR positive staff, we found 30%, 60%, and 60%. Additional antibody tests were performed in nine residents between day 11 and 14 after the positive PCR test. Of those, 7 (78%) tested positive on at least one antibody. When retesting three weeks later, all remaining residents also tested positive. <h3>conclusions</h3> Recently it was reported that in Belgium antibodies are present in 3-4% of the general population. Although, the prevalence in our residents is higher, the number is largely insufficient for herd immunity. In staff members of the regional hospital the prevalence of antibodies was 6%. The higher prevalence in nursing home staff (21%) may be related to the complete absence of good quality protection in the first weeks of the outbreak. <h3>Article summary</h3> <h3>Strengths and limitations of this study</h3> - This is the first study in Belgium examining the prevalence of COVID-19 and the presence of antibodies in residents and staff members of a nursing home - The internal procedural control was positive -with one exception- in all tests, which suggests good quality sampling and testing. - Some degree of selection bias should be assumed in residents, since some residents were absent; mostly from hospitalisation or death which can be related to the presence of COVID-related disease. - The study was set up in one nursing home and is consequently not representative for the whole of the Flemish community
Serum total cholesterol and long-term coronary heart disease mortality in different cultures. Twenty-five-year follow-up of the seven countries study
Authors: W. M. Verschuren
Journal: JAMA (1995)

<h3>Objective.</h3> —To compare the relationship between serum total cholesterol and long-term mortality from coronary heart disease (CHD) in different cultures. <h3>Design.</h3> —Total cholesterol was measured at baseline (1958 through 1964) and at 5- and 10-year follow-up in 12 467 men aged 40 through 59 years in 16 cohorts located in seven countries: five European countries, the United States, and Japan. To increase statistical power six cohorts were formed, based on similarities in culture and cholesterol changes during the first 10 years of follow-up. <h3>Main Outcome Measures.</h3> —Relative risks (RRs), estimated with Cox proportional hazards (survival) analysis, for 25-year CHD mortality for cholesterol quartiles and per 0.50-mmol/L (20-mg/dL) cholesterol increase. Adjustment was made for age, smoking, and systolic blood pressure. <h3>Results.</h3> —The age-standardized CHD mortality rates in the six cohorts ranged from 3% to 20%. The RRs for the highest compared with the lowest cholesterol quartile ranged from 1.5 to 2.3, except for Japan's RR of 1.1. For a cholesterol level of around 5.45 mmol/L (210 mg/dL), CHD mortality rates varied from 4% to 5% in Japan and Mediterranean Southern Europe to about 15% in Northern Europe. However, the relative increase in CHD mortality due to a given cholesterol increase was similar in all cultures except Japan. Using a linear approximation, a 0.50-mmol/L (20-mg/dL) increase in total cholesterol corresponded to an increase in CHD mortality risk of 12%, which became an increase in mortality risk of 17% when adjusted for regression dilution bias. <h3>Conclusion.</h3> —Across cultures, cholesterol is linearly related to CHD mortality, and the relative increase in CHD mortality rates with a given cholesterol increase is the same. The large difference in absolute CHD mortality rates at a given cholesterol level, however, indicates that other factors, such as diet, that are typical for cultures with a low CHD risk are also important with respect to primary prevention. (<i>JAMA</i>. 1995;274:131-136)
"Intractable" Ascites in Cirrhosis: Its Management by a Multiple Diuretic Approach
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A new scalar electrocardiographic computer program. Clinical evaluation
Authors: L. Crevasse
Journal: JAMA (1973)

A new computer electrocardiographic program has been evaluated on 1000 electrocardiograms and compared with clinical interpretation. The computer can differentiate normal from abnormal ECGs with 97% reliability. The computer contour statement accuracy was almost identical with the 92% clinical accuracy. False-positives and false-negatives were comparable. A major flaw in the computer analysis is the inability to analyze complex arrhythmias such as atrioventricular dissociation, atrial arrhythmia with varying block, or sinus rhythm with multiple ectopic events; however, the program consistently states "undetermined rhythm" for these arrhythmias. With the exception of complex arrhythmias this program seems adequate for routine analysis of ECGs with minimal physician overread.
Pangenotypic therapies glecaprevir-pibrentasvir (G-P) and sofosbuvir-velpatasvir-voxilaprevir (S-V-V) after failure with interferon (IFN)-free direct-acting antiviral (DAA) treatment for hepatitis C
Authors: Steven Flamm, Naoky Tsai, Bruce Bacon, Michael Curry, Scott Milligan, Nicole Wick, Zobair Younossi, Nezam Afdhal
Journal: Journal of Hepatology (2020)
A phase I/II study of oral melphalan (MEL) combined with panobinostat (PAN) for patients with relapsed or refractory (R/R) multiple myeloma (MM).
Authors: T. Kazamel, J. R. Berenson, O. Yellin, R. V. Boccia, J. Matous, K. A. Dressler, Y. Nassir, S. Rothstein, R. Swift
Journal: Journal of Clinical Oncology (2011)

e18574 Background: We and others have shown that PAN, a potent histone deacetylase inhibitor (HDACi), significantly inhibits the growth of MM cells in vitro and enhances the cytotoxicity triggered by chemotherapeutic agents. Using our SCID-hu models of MM, we have also shown an increased inhibition of MM cell growth in vivo when PAN was combined with low doses of melphalan compared to treatment with either drug alone. Thus, these preclinical studies provided the rationale for evaluating the combination of oral melphalan with oral PAN for the treatment of MM patients with relapsed or refractory disease. Methods: Thus, we initiated a Phase I/II, open-label, dose-escalation study to treat R/R MM patients using oral PAN every Monday, Wednesday and Friday in combination with oral MEL (0.05 mg/kg) on days 1-5 of a 28 day cycle. After amendments to dose & schedule because of toxicity including cytopenias and fatigue, PAN 15 mg is now being administered with oral MEL 0.05 mg/kg on days 1, 3 & 5 of a 28-day cycle in the current cohort as part of the Phase I portion of the trial. Results: To date, 25 (of 40 planned) patients have been enrolled with a median of 4 (4-17) prior regimens. Sixteen were previously treated with MEL. To date, 4 patients (16%) have shown objective responses to this combination with 2 complete (8%) and 2 partial (8%) responses. An additional 11 (44%) patients have had stable disease while 10 (40%) have progressed while on study. Fourteen patients experienced grade 3 or 4 adverse events, including: reversible neutropenia (n=7), reversible thrombocytopenia (n=9), reversible worsening anemia (n=1), and one case each of a forearm rash, fatigue/weakness, hypokalemia, and hyponatremia. Conclusions: The combination of PAN and low-dose oral MEL has shown an encouraging response rate (16%) in heavily pretreated patients with relapsed/refractory MM. An expanded Phase II part of the trial will be conducted using this oral combination treatment once the MTD has been determined from the current Phase I portion of the trial.
Trials and tribulations: thoughts on the organisation of multicentre clinical studies.
Authors: Michael Baum, Diana Brinkley, Christopher Elston, G Gresham, ; Mrs, Joan Houghton, Gillian Kearney, Paul Leiberman, John Mr, Joseph Macintyre, J Murray, Gita Rao, ; Mr, William Ross, Jack Thirlwall
Journal: BMJ (1980)

The Cancer Research Campaign Trial concerning the management of early breast cancer recruited well over 2000 patients, thus making it the largest prospective study of the management of cancer on record. The management of such large numbers created specific problems of organisation. It is recommended that the protocol design and proforma should be kept simple. A centralized secretariat should be set up, and statisticians and computer programmers must be concerned at every step, including design and analysis. Large clinical trials are very expensive and should not be embarked on without adequate long-term finance.