tbuckley/cabot-search huggingface dataset:
Marijuana Alert
Authors: Barry Liskow
Journal: JAMA (1986)

Marijuana is a drug that continues to rouse passions. Because it was a symbol of certain political and philosophical attitudes for large segments of the population in the 1960s and 1970s, it is difficult to assess the drug objectively. An attack on marijuana is often taken as an attack on a significant cultural subgroup and its beliefs. Defense of the drug is considered to be support of the drug culture. The need for an ongoing medical assessment of the realistic dangers associated with marijuana is sometimes lost in the fray. This book is clearly a polemic against marijuana. This is not a criticism, for it is a book against marijuana, not its users. Authored by a journalist who has written extensively about marijuana for<i>Reader's Digest</i>since 1978, it presents a lucid, welldocumented argument against any use of cannabis. The book opens with a description of current drug use, especially
Comparison of Two Forms of the Anticlotting Drug Heparin for Treatment of Blood Clots in the Legs
Journal: Annals of Internal Medicine (2001)

Summaries for Patients6 February 2001Comparison of Two Forms of the Anticlotting Drug Heparin for Treatment of Blood Clots in the LegsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-3-200102060-00005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Deep venous thrombosis (DVT) is a condition in which blood clots form in the large leg veins, causing pain and swelling. It is important to treat DVT because clots can break off and travel through the bloodstream to the lungs, a potentially deadly condition called pulmonary embolism. DVT is most commonly treated with blood thinners, usually starting with standard heparin given intravenously (through a small tube inserted into a vein) for 5 to 10 days, followed by warfarin, a pill that is generally taken for at least 3 ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Subcutaneous Enoxaparin Once or Twice Daily Compared with Intravenous Unfractionated Heparin for Treatment of Venous Thromboembolic Disease.” It is in the 6 February 2001 issue of Annals of Internal Medicine (volume 134, pages 191-202). The authors are G Merli, TE Spiro, C-G Olsson, U Abildgaard, BL Davidson, A Eldor, D Elias, A Grigg, D Musset, GM Rodgers, AA Trowbridge, RD Yusen, and K Zawilska, for the Enoxaparin Clinical Trial Group.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSubcutaneous Enoxaparin Once or Twice Daily Compared with Intravenous Unfractionated Heparin for Treatment of Venous Thromboembolic Disease Geno Merli , Theodore E. Spiro , Carl-Gustav Olsson , Ulrich Abildgaard , Bruce L. Davidson , Amiram Eldor , Darlene Elias , Andrew Grigg , Dominique Musset , George M. Rodgers , Arthur A. Trowbridge , Roger D. Yusen , Krystyna Zawilska , and Metrics 6 February 2001Volume 134, Issue 3Page: I-76KeywordsBloodHemorrhageHeparinInflammationLow molecular weight heparinLungsPatientsPulmonary embolismThrombosisVeins ePublished: 6 February 2001 Issue Published: 6 February 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Letter: Ultrasound in diagnosis of parapericardial masses
Authors: F. P. Cardello
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Richard O. Friday, MD (226:82, 1973), described the ultrasound B scan as an aid in the diagnosis of pericardial cysts. We wish to point out that lesions appearing cystic by ultrasound B scan may not always be fluid filled. <h3>Report of a Case.—</h3> A 20-year-old white asymptomatic woman was seen in consultation because of an abnormal chest roentgenogram. A smooth, sharply demarcated circumscribed mass measuring 12 cm in diameter was identified at the right anterior aspect of the heart. Fluoroscopic examination showed a narrow pedicle. The mass was not pulsatile. The roentgenographic impression was a pericardial cyst. It was later noted that mediastinal widening was present (Fig 1). An ultrasound B scan examination revealed that the right paracardiac mass had excellent through-transmission at low gain, which exceeded that of the heart. The far border of the mass was smooth and no internal echoes were noted at medium
Hypercarotenemia in Anorexia Nervosa
Authors: Lord Cohen of Birkenhead
Journal: JAMA (1968)

<h3>To the Editor:—</h3> In the August 12 issue (<b>205</b>:533, 1968) Martin A. Pops, MD, and Arthur D. Schwab, MD, in their paper, "Hypercarotenemia in Anorexia Nervosa," write of this association as "not previously encountered in the available literature." They have overlooked a paper by P. J. Dally, "Carotenaemia Occurring in a Case of Anorexia Nervosa" (<i>Brit Med J</i><b>1</b>:1333, 1959). It is relevant to recall that D.S.P. Patterson in a communication to the Biochemical Society in 1964 (<i>Biochem J</i><b>90</b>:39, 1964) showed that in sheep plasma xanthophyll levels increase in starvation but fall on refeeding. The increase and decrease in the plasma xanthophyll level followed closely the changes in levels of nonesterified fatty acids (NEFA). It is suggested that xanthophyll is released into the plasma during the process of depot fat mobilization.
Announcements
Authors: Jordi Bruix -Barcelona, Yung-Chi Cheng -New Haven, Anuchit Chutaputti - Bangkok, Graham Cooksley -Herston, Gary Davis -Dallas, John Fung -Pittsburgh, Sheung-Tat Fan -Hong Kong, Gish -San Francisco, Mark Kane -Seattle, Hsiang-Fu Kung -Hong Kong, Ching-Lung Lai -Hong Kong, Sum Lee - Seattle, Laurentius Lesmana -Jakarta, Zai-Ping Li, Yun-Fan Liaw -Taipei, Stephen Locarnini -Melbourne, Anna Lok -, Ann Arbor, Michael Manns -Hannover, Patrick Marcellin -Clichy, G Mccaughan -Camperdown, George Mcdonald -Seattle, Amin Nanji -Philadelphia, Nikolai Naoumov -London, Kunio Okuda - Memorial) -Chiba, Masao Omata -Tokyo, Alan Perelson -New, Teerha Mexico, Barbara Piratvisuth -Bangkok, Shir Rehermann -Mary- Land, Sarin -New Kumar, Teresa Delhi, Wright -San Francisco, Craig Shapiro -Beijing, Daniel Shouval -Jerusalem, Jack Wands - Providence, Roger Williams -London, Khin Maung, Win Yangon, Meng-Chao Wu, Yi Yuan
Journal: Journal of Hepatology (2003)
Focal encephalitis due to Pseudomonas pseudomallei
Authors: L. P. Tremonti
Journal: JAMA (1971)

A 22-year-old man made an initial recovery from Pseudomonas pseudomallei sepsis resulting from a "drowning" episode. Several weeks later he developed neurological symptoms which were due to focal encephalitis secondary to the same organism. This is the first reported case of a focal central nervous system infection due to P pseudomallei.
Effects of hemopexin on heme-mediated repression of 5-aminolevulinate synthase and induction of heme oxygenase in cultured hepatocytes
Authors: P Sinclair
Journal: Hepatology (1994)

The serum protein hemopexin is considered to have a major role in the mechanism of the uptake of heme by hepatocytes by means of a heme-hemopexin receptor. Therefore, we examined in primary cultures of adult rat and embryonic chick hepatocytes whether the presence of hemopexin would affect the heme-mediated repression of 5-aminolevulinate synthase activity (the rate-limiting enzyme of heme biosynthesis) and the heme-induced increase of heme oxygenase activity (the rate-limiting step of heme degradation). Both of these heme-mediated effects were partly or entirely prevented by the presence of hemopexin. We conclude that homologous hemopexin, at molar concentrations exceeding that of heme, inhibited the uptake of heme into hepatocytes. These results suggest that heme, in amounts sufficient to affect the ratelimiting steps of heme synthesis and degradation, can only enter hepatocytes in primary culture when the binding capacity of hemopexin for heme has been exceeded or altered. (HEPATOLOGY 1994;20:741–746).
Changing trends in allogeneic bone marrow transplantation for leukemia in the 1980s
Authors: M. M. Bortin
Journal: JAMA (1992)

<h3>Objective.</h3> —To identify changes in practice and outcome of bone marrow transplants for leukemia in the 1980s. <h3>Design.</h3> —Comparison of key explanatory and outcome variables in five 2-year cohorts, from 1980 through 1981 to 1988 through 1989, using a large database of detailed clinical information. <h3>Patients.</h3> —Recipients (7788) of bone marrow transplants for acute lymphoblastic, acute myelogenous, or chronic myelogenous leukemia reported to the International Bone Marrow Transplant Registry, Milwaukee, Wis, by 185 transplant teams worldwide. <h3>Results.</h3> —Linear increases occurred during the periods 1980 through 1981 to 1988 through 1989 as follows with 95% confidence intervals: (1) transplants for chronic myelogenous leukemia from 14%±2% to 35%±2%; (2) transplants from unrelated donors from 1%±1% to 7%±1%; (3) preparative regimens without radiation from 3%±1% to 30%±2%; and (4) use of methotrexate plus cyclosporine to prevent graft-vs-host disease from 2%±1% to 55%±2%. Among recipients of human lymphocyte antigen—identical sibling bone marrow, the 2-year probability of treatment-related mortality decreased by 6% to 22%. The probability of relapse decreased from 46%±6% to 38%±6% in intermediate leukemia but did not change appreciably in early or advanced leukemia. Probabilities of leukemia-free survival improved from 51%±4% to 57%±3% in early leukemia, from 28%±4% to 36%±5% in intermediate leukemia, and from 12%±4% to 18%±5% in advanced leukemia. A separate analysis of a homogenous population of patients indicated that improvements in outcome in the 1980s were due to improvements in transplant practice rather than improved patient selection. <h3>Conclusions.</h3> —Modest increases in leukemia-free survival rates occurred after human lymphocyte antigen—identical sibling bone marrow transplants in the 1980s. Improvements were due primarily to reductions in treatment-related mortality with little or no change in relapse risk. More effective antileukemia strategies and continued reductions in treatment-related toxic effects are needed. (<i>JAMA</i>. 1992;268:607-612)
NSABP Halts B-14 Trial: No Benefit Seen Beyond 5 Years Of Tamoxifen Use
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article NSABP Halts B-14 Trial: No Benefit Seen Beyond 5 Years Of Tamoxifen Use Get access JNCI: Journal of the National Cancer Institute, Volume 87, Issue 24, 20 December 1995, Page 1829, https://doi.org/10.1093/jnci/87.24.1829 Published: 20 December 1995
Innere Sekretion.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Factors influencing the prognosis of infantile eczema—another 10 years
Authors: C.F.H. Vickers
Journal: British Journal of Dermatology (1978)

Journal Article Factors influencing the prognosis of infantile eczema—another 10 years Get access C.F.H. Vickers C.F.H. Vickers Department of Dermatology, University of Liverpool, and Alder Hey Children's Hospital, Liverpool Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 99, Issue s16, 1 December 1978, Page 22, https://doi.org/10.1111/j.1365-2133.1978.tb15220.x Published: 01 December 1978
High Plasma Levels of Soluble P-Selectin Are Predictive for Venous Thromboembolism in Cancer Patients - Results from the Vienna Cancer and Thrombosis Study (CATS).
Authors: Cihan Ay, Ralph Simanek, Rainer Vormittag, Daniela Dunkler, Guelay Alguel, Silvia Koder, Oswald Wagner, Christoph Zielinski, Ingrid Pabinger
Journal: Blood (2007)
Mentally ill offenders in prison.
Journal: BMJ (1985)

Yet again, judges including the Lord Chief Justice have complained of the scandal that mentally ill offenders have to be sent to prison for lack of hospital places.After an appeal to the Court of Appeal a severely mentally dis- ordered woman has been transferred from prison to hospital.1 Wendy Christine Porter, aged 23, has an Intelligence Quotient of 65 and has spent four months in prison since being sentenced in October last year by Judge Verney at Aylesbury Crown Court to life imprisonment for arson and causing criminal damage.2She had previously come before the courts in 1981 accused of arson of a printing works causing £100000 worth of damage.On that occasion the Department of Health had refused her a place in a special hospital, and no other appropriate facilities had been available in the county or region.Milton Keynes Health Authority had paid about £50 000 for her to receive treatment at St Andrews Psychiatric Hospital, Northampton (where there are no secure facilities) under the terms of a three year probation order.In June 1984 St Andrews Hospital discharged her, and within two weeks she had caused £700 worth of damage to a car by scratching graffiti on it.While in a remand hostel she set a wastepaper bin alight and was severely disruptive.St Andrews Hospital was unwilling to readmit her, believing that she would not respond to treatment, and in any case no funds were available to pay for her care there.Neither Buckinghamshire Social Services nor Oxford Regional Health Authority could provide facilities for her treatment.
Alzheimer's Disease
Authors: D L Price, P J Whitehouse, R G Struble
Journal: Annual Review of Medicine (1985)

Significant progress has been made in identifying changes in cholinergic, monoaminergic, and peptidergic neurotransmitter systems in the brains of individuals with Alzheimer's disease. Moreover, neurobiological approaches are beginning to reveal the relationships between these neurotransmitter abnormalities and histological hallmarks of the disease, i.e. neurofibrillary tangles, senile plaques, and loss of specific populations of nerve cells. However, to date, the clinical consequences of these specific neurotransmitter changes remain to be elucidated, the cause of this disorder has not been identified, and no effective therapy is yet available.
StatBite Lynch Syndrome Increases the Risk of Various Cancers
Journal: JNCI Journal of the National Cancer Institute (2010)

Lynch Syndrome Increases the Risk of Various CancersLynch syndrome is best known as an inherited condition that increases the risk of colorectal cancers.But people with the syndrome have a higher risk of other cancers too, including endometrial cancer (43%), stomach cancer (13-19%), and ovarian cancer (9-12%).A slightly increased risk has also been reported for cancers of the small intestine, liver and biliary tract, brain, and ovary, as well as transitional cell carcinoma of the ureters and renal pelvis.
A SAFE FOURTH OF JULY.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Synthetic salmon calcitonin. Treatment of Paget's disease and osteogenesis imperfecta
Authors: E. B. Goldfield
Journal: JAMA (1972)

Synthetic salmon calcitonin was given daily for 90 days as a subcutaneous dose of 50 Medical Research Council units to three patients with active Paget's disease and one patient with osteogenesis imperfecta. Symptomatic improvement occurred in two of the patients with Paget's disease and in the patient with osteogenesis imperfecta. During the three months of treatment, serum alkaline phosphatase, urinary hydroxyproline, and urinary calcium decreased significantly in the patients with Paget's disease, and, in the patient with osteogenesis imperfecta, urinary hydroxyproline decreased, suggesting that this new form of calcitonin is also effective in reducing bone resorption in these diseases. No adverse reactions were observed in our initial studies.
Teratological Research Using In Vitro Systems. V. Nonmammalian Model Systems
Authors: Thomas F. X. Collins
Journal: Environmental Health Perspectives (1987)

In this review of alternative tests to whole-animal rodent studies, the use of sub-mammalian and sub-vertebrate systems is investigated. The history, methodology, known limitations, end points, dose response, and requirements of virus, hydra, planarian, cricket, fish, amphibia, Drosophila, and chicken embryo systems are discussed.
Potential actionable targets in appendiceal cancer detected by immunohistochemistry (IHC), fluorescent in situ hybridization (FISH), and mutational analysis.
Authors: Erkut Borazanci, Sherri Z. Millis, Rebecca A. Feldman, Anatole Ghazalpour, Ramesh K. Ramanathan, Daniel D. Von Hoff
Journal: Journal of Clinical Oncology (2014)

4143 Background: Appendiceal cancers are rare and consist of carcinoid, mucocele, pseudomyxoma peritonei, goblet cell carcinoma, lymphoma, and adenocarcinoma histologies. Current treatment involves surgical resection or debulking, but no standard exists for adjuvant chemotherapy or treatment for metastatic disease. Methods: Samples were identified from 60,000 global tumors analyzed at a referral molecular profiling CLIA-certified laboratory. 460 samples with appendix primary tumor sites were identified (male/female ratio of 2:3; mean age = 55). 62% of samples were adenocarcinomas (used for analysis); the rest consisted of 9% goblet cell, 15% mucinous; 6% pseudomyxoma, and less than 5% carcinoids and 2% neuroendocrine. Tests included sequencing (Sanger or next generation sequencing [NGS]), protein expression (immunohistochemistry [IHC]), and gene amplification (FISH or CISH). Results: % positive of total adenocarcinoma cohort are shown (see Table). Conclusions: Appendiceal adenocarcinomas show high levels of drug resistance proteins (BCRP and MRP1), which highlight the difficulty in treating these tumors and suggest an individualized approach to treatment. Therapeutic options include TOPO1 inhibitors (irinotecan/topotecan), PDGFR antagonists (regorafenib, axitinib), MGMT (temozolamide), and SPARC (nab-paclitaxel). These findings indicate the need to evaluate patient samples for patterns in marker expression and alteration, in order to better understand the molecular biology and formulate a personalized therapy approach in these difficult to treat cancers (supported by a grant from Caris Life Sciences). IHC (n=296) BCRP cKIT cMET EGFR ERCC1 MGMT MRP1 PDGFR PGP PTEN RRM1 SPARC TLE3 TOP2A TOPO1 TS TUBB3 97 18 40 47 42 71 85 31 54 52 28 38 9 38 56 22 32 Seq (n=54) APC ATM FBXW7 GNAS KRAS PIK3CA SMAD4 TP53 11 7 6 18 52 6 20 28
Radiotherapy, Surgery Suggested For Cancer of the Larynx
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Introduction to Gastro-Enterology
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal