tbuckley/cabot-search huggingface dataset:
Genotypic analysis of cutaneous T-cell lymphoma: a comparative study of Southern blot analysis with polymerase chain reaction amplification of the T-cell receptor-γ gene
Authors: N. CURCÓ, O. SERVITJE, M. LLUCIA, J. BERTRAN, A. LIMÓN, M. CARMONA, V. ROMAGOSA, J. PEYRÍ
Journal: British Journal of Dermatology (1997)

Summary The diagnosis of early cutaneous T-cell lymphoma (CTCL) is a difficult point in dermatology. Recently, Southern blot analysis (SBA) and polymerase chain reaction (PCR) have been used to detect clonality in initial lesions in which clinical and histological findings are unspecific. Forty-one, samples from 25 patients with CTCL were investigated for the presence of T-cell receptor-γ gene rearrangement using a nested PCR technique and analysed by polyacrylamide gel electrophoresis (PAGE). Conventional SBA was also performed on 28 samples from 20 of these patients. In addition, 20 samples corresponding to patients with large plaque parapsoriasis (LPP), cutaneous B-cell lymphoma (CBCL) and eczema were analysed by PCR in the same way as were the CTCL specimens. Most of the CTCL specimens (81%) showed clonality on PCR analysis. Among patients with mycosis fungoides, 71% of initial patch lesions and 100% of plaques and tumours showed clonal disease. Clonality could be detected in three of four histologically negative post-treatment lesions. Clonal rearrangement was detected in one of three patients with LPP and in three of 10 patients with CBCL. None of the samples corresponding to patients with eczema showed positive results. SBA was significantly less sensitive than PCR in detecting clonality in CTCL patients (42% among early disease and 60% among advanced cases). The results indicate that this PCR/PAGE technique is a reliable and useful method for the detection of clonality in early skin lesions of CTCL patients and probably in the identification of silent extracutaneous involvement.
THE CLIMATE OF COLORADO FOR RESPIRATORY DISEASES.
Authors: CHARLES DENISON
Journal: JAMA (1898)

<h3>PART I.—THE ATTRIBUTES OF CLIMATE AND AIR-RAREFACTION.</h3> The request of our Chamber of Commerce Committee, to give the facts concerning the kind of climate we have in the vicinity of Denver, is complied with reluctantly, only because the author fears his inability to do the subject justice in the space allotted. The evidence depended upon is too voluminous to mention it all, and the author will have to refer the reader to his other writings<sup>1</sup>for the details, and to state some positive conclusions, which might otherwise be challenged if they were not based upon a twenty-four years residence in Colorado, in which time some thirty-five hundred pulmonary cases have been recorded. Experience is what tells, and the experience of the medical profession in Colorado unquestionably sustains the conclusions here presented. We may differ as to the advisability of inviting the weaker, the invalid class to come out here
Awards, Appointments, Announcements
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Awards, Appointments, Announcements Get access JNCI: Journal of the National Cancer Institute, Volume 86, Issue 16, 17 August 1994, Pages 1194–1195, https://doi.org/10.1093/jnci/86.16.1194-a Published: 17 August 1994
End-of-Life Care
Authors: Daniel P. Sulmasy
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cyanotic Heart Disease in a Neonate
Authors: Joseph T. Ferrucci
Journal: JAMA (1967)

Dr. Joseph H. Lyons: An 18-day-old baby girl was admitted to the hospital for evaluation of apparent congenital heart disease. The child followed an unremarkable pregnancy and delivery and she was cyanotic on the second day of life. On physical examination there was frank cyanosis but no real respiratory distress. A systolic murmur was heard by some examiners, but not confirmed by the cardiac consultant. An electrocardiogram demonstrated left axis deviation. These roentgenograms of the chest were obtained on the infant's admission to the hospital (Fig 1). <h3>Discussion</h3> Dr. Laurence L. Robbins: Dr. Weber, do you want to talk about this? Dr. Alfred L. Weber: In the analysis of this case, I will first describe the roentgenograms of the chest and will try to correlate these with the history, the physical findings, and the electrocardiogram. It is quite obvious that the heart shadow is enlarged with a considerable bulge to
Atomic Power Safety: A Common Sense Approach
Authors: William D. Norwood
Journal: JAMA (1972)

All sources of fuel are needed to supply the increasing power needs of a growing population. Atomic fuel competes economically with fossil fuels under most conditions and eliminates undesirable environmental pollution by stack effluents. Both fossil- and atomic-fueled plants have waste hot water which necessitates controls to prevent changes in the ecology. The 25-year record of health and safety of atomic energy programs in the United States should be comforting to the public. Radiation exposures from commercial power reactors have been a very small fraction of permissible limits, and the Atomic Energy Commission has recently further restricted releases from such reactors so that the average exposure to the public will be only about 1% of that from the natural background.
The treatment of streptococcal pharyngitis
Journal: JAMA (1987)

<h3>To the Editor.—</h3> The review by Colonel Bass of the treatment of streptococcal pharyngitis<sup>1</sup>gives us a helpful historical perspective but skirts some treatment issues that confront physicians today. We can no longer expect nearly all patients with streptococcal pharyngitis who are properly treated to have negative cultures and be asymptomatic after therapy. Today, 19% to 37% of patients have positive posttreatment cultures.<sup>2</sup>Although some feel that these patients are carriers and not a major concern, recent studies (and my clinical experience) suggest that a third of these bacteriologic failures are true infections and true treatment failures, based on antibody titer rise and return of symptoms.<sup>3</sup>Clinically, however, one cannot distinguish a true treatment failure from a carrier whose renewed symptoms are from a viral infection. How then should symptomatic treatment failures be managed? There are patients who develop recurrent streptococcal infections despite appropriate treatment. Most of
Protective Action of Diethylstilbestrol on the Toxicity of Vinblastine in Rats
Journal: JNCI Journal of the National Cancer Institute (1968)

Pretreatment of rats with diethylstilbestrol protects the animals from lethal doses of vinblastine, without altering other biological responses. The degree of protection depends on the total dose of diethylstilbestrol and the duration of treatment. Loss of the incisors is a later effect of recovery from massive doses of vinblastine.
School Health and Health Education with Special Consideration of the Teacher's Part in the School Health Program
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AASLD Abstracts 1-219
Journal: Hepatology (2008)

Background: We previously reported a 38% incidence of living liver donor complications in a retrospective cohort (n=405).However, prospectively collected, standardized, multi-center data on living liver donor complications have not been previously presented.Aim: To summarize living liver donor complications in a multicenter, prospective cohort.Study design: Prospective observational cohort study of living liver donors at nine U.S. transplant centers.Results: Among 194 donors in the prospective cohort, the median length of follow-up was 379 days (range 0 -4 years).Five donation procedures were aborted.There were no complications in this group.Two right lobes were removed but not transplanted (without complication).One hundred thirty-one (69%) donors had no complications and 58 patients (31%) developed 103 (55%) complications.There were 44 Clavien grade 1 complications (44%), 53 grade 2 (53%), and four grade 3 (4%).There were no grade 4 complications.Thirty-seven donors developed one complication (64%) and 21 had from two to five complications.The types of complications included: respiratory (22), infectious (21), biliary (11), incisional hernia (9), depression (8), neuropraxia (6), ascites (3), venous thrombosis (3), re-exploration during donation hospitalization (3), wound dehiscence (1) and encephalopathy (1).Forty-five complications resulted in re-hospitalization.Kaplan-Meier probabilities of the occurrence of a complication by 30 days, 90 days, and one year were 24%, 27%, and 30%, respectively.The corresponding probabilities for an infectious complication were 9.5%, 10%, and 11%, respectively.The Kaplan Meier probability of a biliary complication was 6% by 30 days, and no biliary complications occurred more than 30 days post-donation.Summary: These prospective data demonstrate that complications after living liver donation remain common and confirm our previous retrospective observations.
FTA-ABS Test Sensitivity
Authors: Robert A. Nozik
Journal: JAMA (1971)

<h3>To the Editor.—</h3> I read with interest the article by Goldman and Lantz entitled "FTA-ABS and VDRL Slide Test Reactivity in a Population of Nuns" (<b>217</b>:53-55, 1971). Certainly the fluorescent treponemal antibody absorption (FTA-ABS) test is highly sensitive; however, the specificity of this test is difficult to evaluate. An experimental study in the<i>British Journal of Venereal Disease</i>(<b>46</b>:313, 1970) entitled "Reactivity in the FTA-ABS test of Rabbits Hyperimmunized With Nonpathogenic Treponemes," by Tringali and Cox, addresses itself to this question. In this study the FTA-ABS test was performed on the sera of rabbits hyperimmunized against nonpathogenic treponemes. The FTA-ABS sorbent at the concentration currently used for testing human sera eliminated the treponemal antigen from only two out of 17 of the hyperimmunized rabbits' sera. However, using Reiter sonicate all 17 hyperimmune antisera reacted negatively. This study would imply that unless the sorbent step of the FTA-ABS test
The Newcastle exercise project
Authors: N. Kerse
Journal: BMJ (2000)

<h3>ABSTRACT</h3> <h3>Background</h3> The QRISK3 cardiovascular disease (CVD) risk prediction model was derived using primary care data; however, it is frequently used outside of clinical settings. The use of QRISK3 in epidemiological studies without external validation may lead to inaccurate results, however it has been used multiple times on data from UK Biobank. We aimed to externally evaluate the performance of QRISK3 for predicting 10-year risk of cardiovascular events in the UK Biobank cohort. <h3>Methods</h3> We used data from the UK Biobank, a large-scale prospective cohort study of 403,370 participants aged 40-69 years recruited between 2006 and 2010 in the United Kingdom (UK). We included participants with no previous history of CVD or statin treatment and the outcome was the first occurrence of coronary heart disease, ischaemic stroke or transient ischaemic attack, derived from linked hospital episode statistics (HES) and death registration data (DRD). <h3>Results</h3> Our study population included 233,233 females and 170,137 males, with 9295 and 13,028 incident cardiovascular events, respectively. The overall median follow-up time after recruitment was 11.7 years. The discrimination measure of QRISK3 in the overall population was reasonable (Harrell’s C-Index 0.722 in females and 0.697 in males), this was poorer in older participants (&lt;0.62 in all participants aged 65 or older). QRISK3 had systematic over-prediction of CVD risk in UK Biobank, particularly in older participants, by as much as 20%. <h3>Conclusions</h3> QRISK3 had reasonable overall discrimination for the whole study population, which was best in younger participants. The observed CVD risk in UK Biobank participants was lower than that predicted by QRISK3, particularly for older participants. The UK Biobank cohort is known to be healthier than the general population and therefore it is necessary to recalibrate QRISK3 before using it to predict absolute CVD risk in the UK Biobank cohort.
The AMA and the Federal Government
Authors: Charles L. Hudson
Journal: JAMA (1966)

Two factors make it a pleasure for me to appear today before this House of Delegates. First, it has been 22 weeks since I have had the privilege of being with you. At that time, having been inaugurated President of the Association, I expressed my appreciation to you for the honor you had bestowed upon me. Now, with five months of experience in the office behind me, I wish to repeat that expression of appreciation. Being President of this Association has given me an opportunity that I would never otherwise have had, to travel our nation and some other parts of the world, to meet with thousands of our fellow physicians and other thousands of laymen, and most important, to try to the best of my ability to bring to all of them the story of the American Medical Association as you would wish to have that story told. For
Beverage Can Pull-Tabs
Authors: Lee. F. Rogers
Journal: JAMA (1975)

Potential medical hazards are involved in the procedure of dropping the "pull-tab" into an aluminum beverage can before drinking the contents. We have seen two cases of inadvertent ingestion and one of inadvertent aspiration of the pull-tab. One of the patients who had ingested a pull-tab required endoscopic extraction of the pull-tab from the esophagus, and the patient who had inhaled a pull-tab required an open thoracotomy for removal of the foreign body from the bronchus. Aluminum is not as dense or radiopaque as other metals and is, therefore, frequently difficult to identify on standard roentgenograms. (<i>JAMA</i>233:345-348, 1975)
Insulin-Like Growth Factor-I and Breast Cancer Therapy
Authors: Yasir H. Ibrahim, Douglas Yee
Journal: Clinical Cancer Research (2005)

Abstract Targeting hormonal and growth factor signaling pathways has proven to be useful in the treatment of breast cancer. In vitro, animal, and epidemiologic evidence provide a rationale for the relevance of the insulin-like growth factor (IGF) system to breast cancer biology. The IGF system has been implicated in promoting mitogenic, metastatic, and antiapoptotic phenotypes in breast cancer. As a consequence of the ability of IGF to promote tumorigenesis, pharmacologic interventions targeting the IGF system are being devised. Such strategies include decreasing ligand production, ligand binding, or receptor activation. In this article, directed anti-IGF strategies and the possible clinical impact of using such therapies for treating breast cancer are discussed.
Perfume Dermatitis in Men
Authors: Ernst Epstein
Journal: JAMA (1969)

Perfume dermatitis in men has been caused by allergy to preparations applied to the beard area before or after shaving. The author documented 16 cases in a four-year period, with nine occurring in the last year of this study. This suggests a rising incidence. In ten cases, conventional closed patch tests with patients' perfume preparations were positive; however, six patients were photoallergic and required photo patch tests to demonstrate their allergy. For these six photoallergic patients, conventional nonirradiated patch tests were negative. All patients' dermatitis cleared promptly after stopping use of the incriminated perfumes. The identity of the perfume oils responsible for the allergy is unknown.
Do cervical smears save lives?
Authors: L. Chan
Journal: BMJ (1969)

for any published account of these misfortunes, which are presumably theoretical.I have used the gingival sulcus route of administration of oxytocin with complete success, and, may I dare to suggest, much greater comfort, satisfaction, and safety to the patients.'Ritchie and Brudenell have also published papers describing the satisfactory use of oxytocin administered by absorption through the buccal mucous membrane.2' It would be interesting to know why absorption of a drug through the buccal mucosa is more dangerous than giving the same drug intravenously.-Iam, etc., Croydon,
ANNALS OF THE RHEUMATIC DISEASES
Journal: Annals of the Rheumatic Diseases (1959)

to 71 years with rheumatoid arthritis (21), degenerative joint changes (30), or non-articular rheumatism (46), with "osadrin", a preparation consisting of equal parts of 1 :4-diphenyl-3 :5-dioxypyrazolidine and dimethyl- aminophenyldimethylpyrazolone with the addition of procaine hydrochloride.The average daily dose was 1 ampoule by injection or four to six tablets by mouth for 10 to 40 days.[The dose contained in each ampoule or tablet is not stated.]In a high proportion of cases a significant anti- rheumatic effect of the treatment was demonstrated locally by diminution of pain, muscular spasm, and exudation, and systemically by disappearance of fever and return to normal of the erythrocyte sedimentation rate.The preparation was well tolerated and there was no local tenderness after injection or gastric upset after oral administration.There was no water retention in spite of increased uric acid elimination.The authors state that their results confirm those of German workers who have been using osadrin for well over 5 years.Max Mayer.
Epidemiologists strive to maintain confidentiality of some health data
Authors: Charles Marwick
Journal: JAMA (1984)

Officials at the Centers for Disease Control (CDC) in Atlanta are battling what they see as a major threat to their ability to adequately protect the public health. The agency currently is facing considerable difficulty in keeping confidential much of the sensitive information—including information about patients' sexual practices and information found in medical records—reported to its staff by other physicians in the course of the CDC's investigation of disease outbreaks. The problem the agency faces is not new. It extends back at least a decade. But in recent months, the issue of confidentiality of data reported to the CDC has grown into a major concern. Under the Federal Freedom of Information Act, the agency has been forced to provide material gathered in studies of disease outbreaks to attorneys who ultimately used the information in court action. In two instances, lawyers attempted to make the agency provide the names of physicians
Postnatal health education in Nepal
Authors: C. Stangroom, A. Appleby
Journal: BMJ (1998)

How to use the Risk Tables1 To estimate a person's absolute annual risk of a cardiovascular event (newly diagnosed angina, MI, CHD death, stroke or TIA) identify the table relating to person's sex, diabetes status, smoking status and age (locate closest) 2 Within the table find the cell nearest to the person's blood pressure and TC:HDL-C ratio 3 Compare cell colour with risk level 4 For patients with a strong family history of CHD, increase their risk level by at least one colour category
MinnesotaCare (HealthRight)
Authors: Barbara P. Yawn
Journal: JAMA (1993)

OREGON, Massachusetts, Vermont, New Jersey, Hawaii, and now Minnesota have adopted legislation with broad implications for health care system reform. Each of these reform packages will be examined by other states and the federal government as they attempt to deal with health care system reform policies and issues. Blendon et al<sup>1</sup>recently published a set of characteristics that they felt should be included in any major health care system reform plan (Table 1). The article by Blendon et al was accompanied by an editorial in which Lundberg<sup>2</sup>presented a set of criteria for analyzing the reform packages (Table 2). The criteria of Blendon et al resemble process analysis, whereas Lundberg's criteria involve outcome analysis. Minnesota's new MinnesotaCare (formerly HealthRight) will be analyzed herein with reference to both sets of criteria. (Due to conflict with a trademark in California, the name Health-Right was changed to MinnesotaCare. But that name
Dog-Team Doctor: The Story of Dr. Romig
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal