tbuckley/cabot-search huggingface dataset:
Premature Beats and Exercise
Authors: D. R. Germann
Journal: JAMA (1973)

<h3>To the Editor.—</h3> The recent article "Prognostic Importance of Premature Beats Following Myocardial Infarction" (223:1116, 1973) certainly emphasizes the importance of premature ventricular beats (PVB). The purpose of this letter is to call attention to the group of patients that had the best prognosis. The lowest mortality of all groups was the group of patients that participated in moderate or vigorous exercise and were free of PVBs. Of all the groups that did experience PVBs, mortality was lowest in the vigorous to moderate exercise group. Data review also indicates that those in the moderate or vigorous exercise group had the lowest incidence of PVBs. Exercise has also been noted to reduce PVBs in persons not suffering myocardial infarction.<sup>1</sup> Scientific proof of the cause of predisposition to PVBs is hard to obtain. Raab<sup>2</sup>was a strong spokesman for the theory that there was a myocardial component in myocardial infarction
Highlights from Recent Cancer Literature
Journal: Cancer Research (2015)

Environmental Chemical Exposures and Cancer RiskTo test whether low-dose exposure to mixtures of environmental chemicals might contribute to carcinogenesis, 174 scientists from 28 countries reviewed 11 hallmark phenotypes of cancer, assessing 85 commonly encountered noncarcinogenic chemicals.The cumulative effects of combined exposures to 50 of these chemicals-acting on different pathways and a variety of related systems, organs, tissues, and cells-was likely to produce carcinogenic synergies that would be missed in regulatory testing and toxicologic screening.Thus, individual noncarcinogenic chemicals may interact with one another to cause cancer, suggesting a need for additional research on low-dose combinations of commonly encountered chemicals.(Image adapted from Hanahan and Weinberg:
Augmentation of 1,2-Dimethylhydrazine-lnduced Colon Cancer By Experimental Colitis in Mice: Role of Dietary Vitamin E&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Chester, John F., Gaissert, Henning A., Ross, Jeffrey S., Malt, Ronald A., Weitzman, Sigmund A.
Journal: JNCI Journal of the National Cancer Institute (1986)

Journal Article Augmentation of 1,2-Dimethylhydrazine-lnduced Colon Cancer By Experimental Colitis in Mice: Role of Dietary Vitamin E Get access John F. Chester, John F. Chester Search for other works by this author on: Oxford Academic PubMed Google Scholar Henning A. Gaissert, Henning A. Gaissert Search for other works by this author on: Oxford Academic PubMed Google Scholar Jeffrey S. Ross, Jeffrey S. Ross Search for other works by this author on: Oxford Academic PubMed Google Scholar Ronald A. Malt, Ronald A. Malt Search for other works by this author on: Oxford Academic PubMed Google Scholar Sigmund A. Weitzman Sigmund A. Weitzman 6 6Address reprint requests to Dr. Weitzman. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 76, Issue 5, May 1986, Pages 939–942, https://doi.org/10.1093/jnci/76.5.939 Published: 01 May 1986 Article history Received: 25 June 1985 Accepted: 10 December 1985 Published: 01 May 1986
Demonstration of an Altered &lt;italic&gt;S&lt;/italic&gt;-Adenosylmethionine Synthetase in Human Malignant Tumors Xenografted Into Athymic Nude Mice&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1980)

S-Adenosyimethionine synthetase isoenzymes (EC 2.5.1.6) were studied in human malignant tumors xenografted into athymic nude mice and were studied in normal human and rat tissues. The tumors included 7 melanomas; 4 colon carcinomas; 3 each of mammary, cervical, and ovary carcinomas; 2 each of lung carcinomas and sarcomas; and 1 each of lymphoma and stomach and nasopharyngeal carcinomas. The presence of an altered intermediate Michaelis constant (Km) isoenzyme, previously shown to be a unique characteristic of rat neoplastic tissues, in these tumors was invariably detectable, though the presence of the low-Km isoenzyme characteristic of the enzyme of normal tissues was also evident in many of these tumors. Only tumors demonstrating high rates of growth were devoid of the Iow-Km isoenzyme. The low-Km isoenzyme was the only enzyme detectable in many normal human and rat tissues. Thus this isoenzyme was probably the common enzyme of all tissues. Some additional organ-specific isoenzymes were found, e.g., in the liver and lactating mammary gland. The low-Km isoenzyme in malignant tumors was altered to assume a considerably higher Km value, and this alteration appeared to be a common aberration of malignant tumors.
What's wrong with medical education?
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnosis and Treatment of Fat Embolism
Authors: Charles M. Evarts
Journal: JAMA (1965)

The occurrence of fat embolism as a complication of skeletal trauma has been of interest for more than a century. The controversy in regard to the source of the embolic fat has still not been resolved. The incidence of fat embolism is relatively high both on the battlefield and in civilian life (Table 1).<sup>1-7</sup>The severity of this complication in association with multiple injuries, especially with fractures of long bones, is not generally appreciated. Systemic fat embolism produces a clinical syndrome with characteristic findings and pertinent laboratory results. With a better understanding of the underlying pathophysiological mechanisms, treatment has become more specific and less empirical. <h3>Pathogenesis</h3> The pathogenesis of fat embolism is still subject to conjecture and controversy. The genesis of the embolic fat is postulated as being either mechanical or physiochemical. Although it is possible that intravasation of fat into vascular channels can occur after trauma, recent studies<sup>8</sup>
Elevated Mortality Associated With Armed Conflict--Democratic Republic of Congo, 2002
Journal: JAMA (2003)

In August 1998, citing a need to control insecurity on their western borders, Rwanda and Uganda sent troops into the Democratic Republic of Congo (DRC) (estimated 2002 population: 51 million). Within 6 months, troops from seven neighboring countries were fighting in the DRC, with various Congolese groups supporting different invading armies. During 1998-2002, the majority of the fighting occurred in the DRC's five eastern provinces (1996 population: 19.9 million). To assess the impact of the armed conflict on public health, the International Rescue Committee (IRC), with support from CDC, conducted a nationwide mortality survey to measure DRC's nationwide crude mortality rate (CMR) and to compare CMRs in DRC's five eastern provinces with CMRs in the five western provinces. This report summarizes the results of the survey, which indicate that the overall CMR in the DRC is the highest in the world, with the majority of deaths caused by preventable infectious diseases. The findings underscore the importance of the ongoing peace process, which appears to have contributed to a decrease in mortality rates in eastern DRC, and highlights the importance of collecting population-based health data regularly during armed conflicts.
Septic Shock
Authors: Margaret M. Parker
Journal: JAMA (1983)

PATIENTS suffering from shock secondary to sepsis are common in the practice of a wide variety of specialties—surgery, internal medicine, obstetrics, and pediatrics. Septic shock is frequently a serious complication of otherwise successful surgical or medical intervention, and, therefore, the hemodynamic patterns of this form of shock should be familiar to all physicians potentially caring for acutely ill patients. Although the precise incidence of sepsis and septic shock is difficult to document, recent estimates of gram-negative rod bacteremia in the United States range from 70,000 to 300,000 cases each year.<sup>1,2</sup>Shock complicates approximately 40% of these cases and has a mortality ranging from 40% to 90%. Therefore, gram-negative rod bacteremic shock results in approximately 20,000 to 60,000 deaths each year. The mortality statistics for all sepsis (including gram-positive and gram-negative organisms, fungi, and viruses) would be substantively higher. Therefore, shock secondary to sepsis is a serious common disease with
A Text-Book of Neuropathology.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Medical Aspects of Mustard Gas Poisoning.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Global Strategies for the Control of Rheumatic Fever
Authors: Gene H. Stollerman
Journal: JAMA (1983)

The global disparities in the prevalence of rheumatic fever<sup>1</sup>are a vivid reminder of the relation of high standards of housing and health care to control of the disease. Rheumatic fever still ranks as a major health problem in large segments of the populations of Asia, Africa, and South America.<sup>2</sup>In fact, the industrialization of some native or aboriginal Third World populations has resulted in an alarming prevalence of rheumatic fever, estimated to be increasing in some provinces of South Africa.<sup>2-4</sup>These estimates actually exceed rheumatic fever incidence rates of 61/100,000 per year calculated for Manhattan schoolchildren between 1963 and 1965, a time when the disease's incidence was already declining rapidly in the United States. In this issue of<i>JAMA</i>(p 895), Land and Bisno report their conscientious effort to determine the incidence of acute rheumatic fever in Memphis-Shelby County, Tennessee, for the years 1977 through 1981.
Mammalian Anatomy. With Special Reference to the Cat.
Journal: JAMA (1904)

The common cat is the most available animal for the anatomy student in biology. As there are plenty of cats and as their number has to be frequently curtailed they afford ample dissection material for the genuine student in this department; it is, therefore, wise to select the cat as a typical illustration of the work of comparative mammalian anatomy. Dr. Davison has given us a convenient text-book which will be of service to students.
Effect of brief hypoxia on reperfusion arrhythmias and release of Ca2+ by rat heart homogenate blocked by ryanodine
Authors: M. Tani, Y. Asakura, H. Hasegawa, K. Shinmura, Y. Ebihara, Y. Nakamura
Journal: Cardiovascular Research (1996)

Objectives: We previously reported that a brief period of hypoxic perfusion (BHP) prior to ischemia in rat hearts improved functional recovery upon reperfusion with reduced Ca2+ overload. The present study was designed to determine whether the effect of BHP would be associated with a reduction in reperfusion arrhythmias and a preservation of function of the sarcoplasmic reticulum (SR). Methods: Hearts were subjected to 40 min of global ischemia and 30 min of reperfusion after a 20 min period of oxygenated perfusion (oxygenated group: OG), or a 10 min period of oxygenation and 10 min of hypoxic perfusion (hypoxic group: HG). We evaluated the release of Ca2+ by SR blocked by ryanodine, the recovery of left ventricular function, and the reperfusion induced ventricular tachycardia/fibrillation (VT/VF). Results: Functional recovery improved and the incidence and duration of reperfusion VT/VF were reduced in HG. In HG the uptake of Ca2+ in SR decreased during ischemia, but this decrease was less than that in OG. However, recovery of Ca2+ uptake after reperfusion did not differ between groups. The release of Ca2+ by SR blocked by ryanodine was inhibited in HG throughout the ischemia-reperfusion sequence. Conclusions: Observations suggest that the benefits of BHP on recovery of function and reperfusion arrhythmias were associated with a decrease in release of Ca2+ by SR blocked by ryanodine.
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Capillary Endothelial Cell Migration: Stimulating Activity of Aqueous Humor From Patients With Ocular Cancers&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1983)

In double-masked studies, various concentrations of aqueous humor (AH) from 157 patients (208 samples) with ocular cancers, nonmalignant ocular lesions, and normal eyes were added to bovine capillary endothelial (BCE) cells plated onto gold-coated cover slips. The phagokinetic tracks made by 100 cells at each concentration were traced, and the mean area of migration plus or minus the standard error of the mean was determined. Data are expressed as the percentages of increase in mean track area made by 100 cells incubated in medium that contained AH samples beyond the mean area of 100 cells incubated in medium alone. The percentage increases in migration-stimulating activity were as follows: a) malignant ocular disease—retinoblastoma (30 samples), 34±2; malignant melanoma (55 samples), 37±3; b) nonmalignant ocular disease—cataracts, glaucoma, pseudoglioma, and diabetic retinopathy (36 samples), 14±2; c) control AH—no ocular disease (51 samples), 9±1; normal eyes and systemic cancer (36 samples), 38±6. The percentage increase in endothelial cell migration was as great in cases of systemic cancer as it was in cases of ocular cancer. The endothelial cell migration-stimulating activity in AH from patients with intraocular cancers was significantly higher than the levels in the other groups of patients having no systemic cancer (P«.001). In addition, when the results were compared in the control group and the group with benign ocular disease, no significant differences were detected (P>.01).
Paclitaxel (Taxol®) for the treatment of lymphoma
Authors: A. Younes, J.P. Ayoub, A. Sarris, L. North, O. Pate, P. McLaughlin, M.A. Rodriguez, J. Romaguera, F. Hagemeister, C. Bachier, A. Preti, F. Cabanillas
Journal: Annals of Oncology (1997)
Simian Sarcoma Virus, Type 1 &lt;italic&gt;(Lagothrix):&lt;/italic&gt; Focus Assay and Demonstration of Nontransforming Associated Virus&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Lauren G. Wolfe, Richard K. Smith, Friedrich Deinhardt
Journal: JNCI Journal of the National Cancer Institute (1972)

The focal transformation of marmoset lung cells by simian sarcoma virus, type 1 (SSV-1) was quantitative without an agar overlay required. Pretreatment of the indicator cells with diethylaminoethyl-dextran increased the sensitivity 10–50 times. A 10-100 fold excess of nontransforming associated virus (SSAV-1) was demonstrated in SSV-1 stocks by interference tests and electron microscopy. SSV-1 produced by transformed marmoset, human, or cat cells retained its oncogenicity for marmosets.
Особливості змін імунологічних показників у хворих на хронічні запальні захворювання кишечника з анемічним синдромом
Authors: T.Y. Boyko, S.Yu. Yegorova, O.V. Sorochan
Journal: GASTROENTEROLOGY (2013)

Обстежено 69 хворих на хронічні запальні захворювання кишечника з анемічним синдромом. Групу порівняння становили хворі на хронічні захворювання кишечника без анемії. Встановлено, що розвиток анемії асоціюється з експресією прозапальних цитокінів ІЛ-6 та особливо ФНП-α. Виявлено пригнічення поглинальної активності нейтрофільних гранулоцитів, що сприяє хронізації запального процесу. Посиленню деструктивних процесів сприяє підвищення продукції супероксидного аніону нейтрофільними гранулоцитами і моноцитами.
Medical Schools in the United States
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Analgesic-Abuse Nephropathy
Authors: George A. Blewitt
Journal: JAMA (1982)

<h3>To the Editor.—</h3> A recent editorial inThe Journalby Goldberg (1982; 247:64), concerning analgesic combinations and the nephropathy associated with analgesic abuse, raises several points that give cause to reexamine this entity. Over-the-counter analgesic combinations are sold and labeled for the temporary relief of minor aches, pains, and headache. The labeling is specific in this regard, and carries warnings and cautions that provide for finite limits of use. The labeling also warns that prolonged use should only be permitted under the care of a physician. The first issue then, with regard to the role of analgesics or combinations of analgesics in producing nephrotoxicity, is abuse—as reported in the literature for nearly 30 years.<sup>1</sup>This literature supports the opinion that analgesic abuse arises from psychologically motivated causes, not from any true addicting properties of the components. At the least, then, this highlights the need for accurately terming the disease
Do neuroleptic drugs hasten cognitive decline in dementia?
Authors: C Holmes, O Fortenza, J Powell, S Lovestone, R. Tobiansky, M. Blanchard, P W Bentham, S E Goh, E M Gregg, P Madeley, A R A Patel, A P Taylor, R. McShane, T. Hope, R. Jacoby, J. Keene, C. Fairburn
Journal: BMJ (1997)