FIBRINOGEN DEFICIENCY
Authors: MILTON S. SACKS
Journal: Annals of Internal Medicine (1955)

Editorial1 November 1955FIBRINOGEN DEFICIENCYMILTON S. SACKS, M.D.MILTON S. SACKS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-5-1139 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent studies demonstrating fibrinogenopenia as the basic defect in a widely disparate group of hemorrhagic disorders have aroused renewed interest in this component of the coagulation mechanism. Included among these hemorrhagic disorders are the abnormal bleeding associated with some cases of abruptio placentae, amniotic fluid embolism, retention of a dead fetus in utero, carcinoma of the prostate with metastases, and pulmonary surgery. Interest has also been focused on the implications and applications of the fibrinolytic system which exists normally in the blood. A knowledge of some aspects of fibrinogen metabolism is fundamental to the understanding of these entities.Fibrinogen, a...1 BaileyBettelheim KFR: The nature of the fibrinogen-thrombin reaction, Brit. M. Bull. 11: 50, 1955. CrossrefMedlineGoogle Scholar2 Lorand L: Interaction of thrombin and fibrinogen, Physiol. Rev. 34: 742, 1954. CrossrefMedlineGoogle Scholar3 Ferry JD: Polymerization of fibrinogen, Physiol. Rev. 34: 753, 1954. CrossrefMedlineGoogle Scholar4 BiggsMacfarlane RRG: Human blood coagulation and its disorders, 1953, C. C Thomas, Springfield, Ill., p. 335. Google Scholar5 AlexanderGoldsteinRichLeBolloc'hDiamondBorges BRLAGLKW: Congenital afibrinogenemia. A study of some basic aspects of coagulation, Blood 9: 843, 1954. CrossrefMedlineGoogle Scholar6 GitlinBorges DWH: Studies on the metabolism of fibrinogen in two patients with congenital afibrinogenemia, Blood 8: 679, 1953. CrossrefMedlineGoogle Scholar7 PinnigerPrunty JLFT: Some observations on the blood clotting mechanism. The role of fibrinogen and platelets with reference to a case of congenital afibrinogenemia, Brit. J. Exper. Path. 27: 200, 1946. MedlineGoogle Scholar8 MacfarlaneBiggs RGR: Fibrinolysis. Its mechanism and significance, Blood 3: 1167, 1948. CrossrefMedlineGoogle Scholar9 ChristensenMacLeod LRCM: A proteolytic enzyme of serum: characterization, activation and reaction with inhibitors, J. Gen. Physiol. 28: 559, 1945. CrossrefMedlineGoogle Scholar10 AstrupPermin TPM: Fibrinolysis in the animal organism, Nature 159: 681, 1947. CrossrefMedlineGoogle Scholar11 TillettGarner WSRL: The fibrinolytic activity of hemolytic streptococci, J. Exper. Med. 58: 485, 1933. CrossrefMedlineGoogle Scholar12 TagnonLevensonDavidsonTaylor HJSMCSFH: The occurrence of fibrinolysis in shock, with observations on the prothrombin time and the plasma fibrinogen during hemorrhagic shock, Am. J. M. Sc. 211: 88, 1946. CrossrefMedlineGoogle Scholar13 WestphalKocholatyMcDonaldKingJensen UWBEH: Studies on proteolytic, fibrinolytic, antitryptic and antifibrinolytic activities in the blood of rats, Proc. Soc. Exper. Biol. and Med. 75: 862, 1950. CrossrefMedlineGoogle Scholar14 FantlSimon PSE: Fibrinolysis following electrically induced convulsions, Australian J. Exper. Biol. and M. Sc. 26: 521, 1948. CrossrefMedlineGoogle Scholar15 MacfarlaneBiggs RGR: Observations on fibrinolysis: spontaneous activity associated with surgical operations, trauma, etc., Lancet 2: 862, 1946. CrossrefMedlineGoogle Scholar16 Latner AL: Anxiety as a cause of fibrinolysis, Lancet 1: 194, 1947. CrossrefMedlineGoogle Scholar17 Truelove SC: Fibrinolysis and the eosinophil count, Clin. Sc. 10: 229, 1951. MedlineGoogle Scholar18 Ungar G: Thrombosis and stress: role of the fibrinolytic system, Proc. Int. Conf. on Thrombosis and Embolism, 1954, Benno Schwabe and Co., Basle, p. 421. Google Scholar19 PrichardVann RWRL: Congenital afibrinogenemia: report on a child without fibrinogen and review of the literature, Am. J. Dis. Child. 88: 703, 1954. Google Scholar20 LewisFerguson JHJH: Afibrinogenemia: report of a case, Am. J. Dis. Child. 88: 711, 1954. Google Scholar21 Bjorkman SE: Three cases of polycythemia with fibrinopenia, Acta med. Scandinav. 129: 472, 1948. CrossrefMedlineGoogle Scholar22 CooperbergNeiman AAGM: Fibrinogenopenia and fibrinolysis in acute myelogenous leukemia, Ann. Int. Med. 42: 706, 1954. Google Scholar23 Copley AL: Studies on human placental thromboplastin in vitro and in vivo, Science 101: 436, 1945. CrossrefMedlineGoogle Scholar24 Schneider CL: Complications of late pregnancy in rabbits induced by experimental placental trauma, Surg., Gynec. and Obst. 90: 613, 1950. MedlineGoogle Scholar25 RatnoffConley ODCL: Studies on afibrinogenemia. II. Defibrinating effect of dog blood on intravenous injection of thromboplastic material, Bull. Johns Hopkins Hosp. 81: 1, 1947. MedlineGoogle Scholar26 Dieckmann WJ: Blood chemistry and renal function in abruptio placentae, Am. J. Obst. and Gynec. 31: 734, 1937. CrossrefGoogle Scholar27 RatnoffLausterShollSchilling ODCFJGMO: Hemorrhagic state during pregnancy with presence of maternal Rh antibodies, death of fetus and hypofibrinogenemia, Am. J. Med. 13: 111, 1952. CrossrefMedlineGoogle Scholar28 WeinerReidRobyDiamond AEDECCLK: Coagulation defects with intrauterine death from Rh isosensitization, Am. J. Obst. and Gynec. 60: 1015, 1950. CrossrefMedlineGoogle Scholar29 JurgensTrautwein RH: Ueber Fibrinopenie (Fibrinogenopenie) beim erwachsenen nebst Bemerkungen über die Herkunft des Fibrinogens, Deutsch. Arch. f. klin. Med. 169: 28, 1930. Google Scholar30 MarderWeinerShulmanShapiro MMPS: Afibrinogenemia occurring in a case of malignancy of the prostate with bone metastases, N. Y. State M. J. 49: 1197, 1949. MedlineGoogle Scholar31 SealeJampolisBargen RARWJA: Clotting defect in the presence of metastatic carcinoma of the prostate: case report, Surg. Clin. N. A. 31: 1111, 1951. CrossrefMedlineGoogle Scholar32 TagnonWhitmoreShulman HJWFNR: Fibrinolysis in metastatic cancer of the prostate, Cancer 5: 9, 1952. CrossrefMedlineGoogle Scholar33 CraneWareHamilton JJAGJ: Spontaneous afibrinogenemia in cancer of the prostate: report of two cases, Trans. West. Sect. Am. Urol. A. 21: 65, 1954. MedlineGoogle Scholar34 HugginsVail CVC: Plasma coagulation and fibrinogenolysis by prostatic fluid and trypsin, Am. J. Physiol. 139: 129, 1943. CrossrefGoogle Scholar35 TagnonWhitmoreSchulmanKravitz HJWFPSC: The significance of fibrinolysis occurring in patients with metastatic cancer of the prostate, Cancer 6: 63, 1953. CrossrefMedlineGoogle Scholar36 SoulierMatheyBollochDaumetFayet JPJAGPH: Syndromes hemorragiques mortels avec incoagulabilité totale par défibrination et avec fibrinolyse, Rev. d'hémat. 7: 30, 1952. MedlineGoogle Scholar37 PennWalker SRJH: Defective blood coagulation following pulmonary surgery, N. England J. Med. 250: 764, 1954. CrossrefMedlineGoogle Scholar38 TillettSherry WSS: The effect in patients of streptococcal fibrinolysin (streptokinase) and streptococcal desoxyribonuclease on fibrinous, purulent and sanguineous pleural exudations, J. Clin. Investigation 28: 173, 1949. CrossrefGoogle Scholar39 Cathie IA: Bacterial fibrinolysin, its possible therapeutic application in tuberculous meningitis, J. Clin. Path. 2: 73, 1949. CrossrefMedlineGoogle Scholar40 GrossiClifftonCannamela CEEEDA: The lysis of intravascular thrombi in rabbits with human plasmin (fibrinolysin), Blood 9: 310, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MILTON S. SACKS, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIntramural gastrointestinal hemorrhageAlterations in Plasma Protein Patterns in DiseaseAcquired fibrinogenopeniaOn the Probable Mechanism of Intravascular Clotting 1 November 1955Volume 43, Issue 5 Page: 1139-1146 Keywords Amniotic fluid Blood Fetuses Fibrinogen Hemorrhage Pulmonary embolism Surgery ePublished: 1 December 2008 Issue Published: 1 November 1955 PDF downloadLoading ...