tbuckley/cabot-search huggingface dataset:
Progress in the surgical treatment of sacrococcygeal pilonidal sinus: a review
Authors: Peiliang Wu, Yingyi Zhang, Yewei Zhang, Shuang Wang, Zhe Fan
Journal: International Journal of Surgery (2023)

A pilonidal sinus (PS) is an acquired disease resulting from recurrent infections and chronic inflammation. A PS involving the sacrococcyx is referred to as a sacrococcygeal PS (SPS). An SPS is a rare chronic infectious disease for which surgery is a good choice. The incidence of SPS has gradually increased worldwide in recent years. However, surgeons have not reached a consensus on the preferred surgical approach for SPS. The authors performed a systematic review and meta-analysis to analyze differences in the efficacy of different surgical approaches for the treatment of SPS.A systematic search was conducted in the PubMed database covering the period from 1 January 2003, to 28 February 2023. The primary outcome parameters were recurrence and infection. Finally, statistical analysis (meta-analysis) was carried out using RevMan 5.4.1 software. In addition, we systematically reviewed the latest progress in the surgical treatment of SPS over the past 20 years, especially as reported in the past 3 years.Twenty-seven articles, 54 studies, and 3612 participants were included in this meta-analysis. The recurrence rate following the midline closure (MC) technique was much higher than that of other techniques. Among the techniques analyzed, the differences between MC and Limberg flap (LF), and between MC and marsupialization were statistically significant [ P =0.0002, risk ratio (RR)=6.15, 95% CI 2.40, 15.80; P =0.01, RR=12.70, 95% CI 1.70, 95.06]. The recurrence rate of open healing was higher than that of the Karydakis flap (KF) technique, and the difference was statistically significant ( P =0.02, RR=6.04, 95% CI 1.37, 26.55). Most of the results comparing MC with other techniques suggested that the former had a higher infection rate, and the difference between MC and LF was statistically significant ( P =0.0005, RR=4.14, 95% CI 1.86, 9.23). Comparison between KF and LF, modified LF and KF showed that the differences were not statistically significant in terms of recurrence and infection ( P ≥0.05).There are various surgical treatment options for SPS, including incision and drainage, excision of diseased tissue with primary closure and secondary healing, and minimally invasive surgery. It is still not possible to determine which surgical technique should be considered the gold standard for treatment, as even the results of different researchers using the same operation method are conflicting. But what is certain is that the midline closure technique has a much higher incidence of postoperative recurrence and infection than other techniques. Therefore, the anorectal surgeon should formulate the most suitable individualized plan for the patient based on a comprehensive evaluation of the patient's wishes, appearance of the SPS, and the professional ability of the surgeon.
Randomized Trial of Early Detection and Treatment of Postpartum Hemorrhage
Authors: Ioannis Gallos, Adam Devall, James Martin, Lee Middleton, Leanne Beeson, Hadiza Galadanci, Fadhlun Alwy Al-beity, Zahida Qureshi, G. Justus Hofmeyr, Neil Moran, Sue Fawcus, Lumaan Sheikh, George Gwako, Alfred Osoti, Ashraf Aswat, Kristie-Marie Mammoliti, Kulandaipalayam N. Sindhu, Marcelina Podesek, Isobelle Horne, Rebecca Timms, Idnan Yunas, Jenipher Okore, Mandisa Singata-Madliki, Edna Arends, Aminu A. Wakili, Ard Mwampashi, Sidrah Nausheen, Shah Muhammad, Pallavi Latthe, Cherrie Evans, Shahinoor Akter, Gillian Forbes, David Lissauer, Shireen Meher, Andrew Weeks, Andrew Shennan, Anne Ammerdorffer, Eleanor Williams, Tracy Roberts, Mariana Widmer, Olufemi T. Oladapo, Fabiana Lorencatto, Meghan A. Bohren, Suellen Miller, Fernando Althabe, Metin Gülmezoglu, Jeffrey M. Smith, Karla Hemming, Arri Coomarasamy
Journal: New England Journal of Medicine (2023)

Delays in the detection or treatment of postpartum hemorrhage can result in complications or death. A blood-collection drape can help provide objective, accurate, and early diagnosis of postpartum hemorrhage, and delayed or inconsistent use of effective interventions may be able to be addressed by a treatment bundle.
Copper‐Single‐Atom Coordinated Nanotherapeutics for Enhanced Sonothermal‐Parallel Catalytic Synergistic Cancer Therapy
Authors: Ye Qi, Shuangsong Ren, Junwei Ye, Shengnan Bi, Lei Shi, Yueguang Fang, Guangyao Wang, Y. Zou Finfrock, Jun Li, Ying Che, Guiling Ning
Journal: Advanced Healthcare Materials (2023)

Phototherapy and sonotherapy are recognized by scientific medicine as effective strategies for treating certain cancers. However, these strategies have limitations such as an inability to penetrate deeper tissues and overcome the antioxidant tumor microenvironment. In this study, a novel "BH" interfacial-confined coordination strategy to synthesize hyaluronic acid-functionalized single copper atoms dispersed over boron imidazolate framework-derived nanocubes (HA-NC_Cu) to achieve sonothermal-catalytic synergistic therapy is reported. Notably, HA-NC_Cu demonstrates exceptional sonothermal conversion performance under low-intensity ultrasound irradiation, attained through intermolecular lattice vibrations. In addition, it shows promise as an efficient biocatalyst, able to generate high-toxicity hydroxyl radicals in response to tumor-endogenous hydrogen peroxide and glutathione. Density functional theory calculations reveal that the superior parallel catalytic performance of HA-NC_Cu originates from the CuN4 C/B active sites. Both in vitro and in vivo evaluations consistently demonstrate that the sonothermal-catalytic synergistic strategy significantly improves tumor inhibition rate (86.9%) and long-term survival rate (100%). In combination with low-intensity ultrasound irradiation, HA-NC_Cu triggers a dual death pathway of apoptosis and ferroptosis in MDA-MB-231 breast cancer cells, comprehensively limiting primary triple-negative breast cancer. This study highlights the applications of single-atom-coordinated nanotherapeutics in sonothermal-catalytic synergistic therapy, which may create new opportunities in biomedical research.
Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients
Authors: Alex S. Genshaft, Sonu Subudhi, Arlin Keo, Juan Diego Sanchez Vasquez, Nádia Conceição-Neto, Deeqa Mahamed, Lauke L. Boeijen, Nadia Alatrakchi, Chris Oetheimer, Mike Vilme, Riley Drake, Ira Fleming, Nancy Tran, Constantine Tzouanas, Jasmin Joseph-Chazan, Martin Arreola Villanueva, Harmen J. G. van de Werken, Gertine W. van Oord, Zwier M. A. Groothuismink, Boris J. Beudeker, Zgjim Osmani, Shirin Nkongolo, Aman Mehrotra, Kurt Spittaels, Jordan Feld, Raymond T. Chung, Robert J. de Knegt, Harry L. A. Janssen, Jeroen Aerssens, Jacques Bollekens, Nir Hacohen, Georg M. Lauer, Andre Boonstra, Alex K. Shalek, Adam J. Gehring
Journal: Hepatology (2023)

Background and Aims: HBV infection is restricted to the liver, where it drives exhaustion of virus-specific T and B cells and pathogenesis through dysregulation of intrahepatic immunity. Our understanding of liver-specific events related to viral control and liver damage has relied almost solely on animal models, and we lack useable peripheral biomarkers to quantify intrahepatic immune activation beyond cytokine measurement. Our objective was to overcome the practical obstacles of liver sampling using fine-needle aspiration and develop an optimized workflow to comprehensively compare the blood and liver compartments within patients with chronic hepatitis B using single-cell RNA sequencing. Approach and Results: We developed a workflow that enabled multi-site international studies and centralized single-cell RNA sequencing. Blood and liver fine-needle aspirations were collected, and cellular and molecular captures were compared between the Seq-Well S 3 picowell-based and the 10× Chromium reverse-emulsion droplet–based single-cell RNA sequencing technologies. Both technologies captured the cellular diversity of the liver, but Seq-Well S 3 effectively captured neutrophils, which were absent in the 10× dataset. CD8 T cells and neutrophils displayed distinct transcriptional profiles between blood and liver. In addition, liver fine-needle aspirations captured a heterogeneous liver macrophage population. Comparison between untreated patients with chronic hepatitis B and patients treated with nucleoside analogs showed that myeloid cells were highly sensitive to environmental changes while lymphocytes displayed minimal differences. Conclusions: The ability to electively sample and intensively profile the immune landscape of the liver, and generate high-resolution data, will enable multi-site clinical studies to identify biomarkers for intrahepatic immune activity in HBV and beyond.
A commentary on ‘Nomograms for predicting the recurrence probability and recurrence-free survival in patients with hepatocellular carcinoma after conversion hepatectomy based on hepatic arterial infusion chemotherapy: a multicenter, retrospective study’ (Int J Surg 2023; 109:1299–310)
Authors: Teh-Ia Huo, Shu-Yein Ho, Jia-I Liao
Journal: International Journal of Surgery (2023)

aDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan bSchool of Medicine cInstitute of Pharmacology, National Yang Ming Chiao Tung University, Taipei, Taiwan dDivision of Gastroenterology and Hepatology, Min-Sheng General Hospital, Taoyuan, Taiwan eDivision of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan T.-I. Huo and S.-Y. Ho contributed equally to this study. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Professor of Medicine, Department of Medical Research, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Taipei 11217, Taiwan, Tel: + 886 2 2871 2121 Ext.: 7434, Fax: + 886 2 2873 9318. E-mail address: [email protected] (T.-I. Huo). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Cell‐Sized Lipid Vesicles as Artificial Antigen‐Presenting Cells for Antigen‐Specific T Cell Activation (Adv. Healthcare Mater. 12/2023)
Authors: Jui‐Yi Chen, Sudhanshu Agrawal, Hsiu‐Ping Yi, Derek Vallejo, Anshu Agrawal, Abraham P. Lee
Journal: Advanced Healthcare Materials (2023)
Architecture‐Engineered Electrospinning Cascade Regulates Spinal Microenvironment to Promote Nerve Regeneration (Adv. Healthcare Mater. 12/2023)
Authors: Yu Tang, Zonghan Xu, Jincheng Tang, Yichang Xu, Ziang Li, Wenbo Wang, Liang Wu, Kun Xi, Yong Gu, Liang Chen
Journal: Advanced Healthcare Materials (2023)

Spinal Cord Repair In article 2202658 by Kun Xi, Yong Gu, Liang Chen, and co-workers, inspired by architecturally reinforced concrete structures, a hydrogel “perfusion” system and electrospinning technology are integrated, and a “concrete” composite support for the repair of nerve injuries is built, skillfully combining the reprogramming of spinal cord injury immune microenvironment and the neurogenic differentiation of neural stem cells. This may serve as a new treatment approach for spinal cord injuries.
AIEgens/Mitochondria Nanohybrids as Bioactive Microwave Sensitizers for Non‐Thermal Microwave Cancer Therapy (Adv. Healthcare Mater. 12/2023)
Authors: Xinghua Yu, Ming Lyu, Xupei Ou, Wenquan Liu, Xing Yang, Xiaoxi Ma, Tianfu Zhang, Longnan Wang, Ying‐Chuan Zhang, Sijie Chen, Ryan T. K. Kwok, Zheng Zheng, Hong‐Liang Cui, Lintao Cai, Pengfei Zhang, Ben Zhong Tang
Journal: Advanced Healthcare Materials (2023)
Intrafibrillar Mineralization and Immunomodulatory for Synergetic Enhancement of Bone Regeneration via Calcium Phosphate Nanocluster Scaffold (Adv. Healthcare Mater. 12/2023)
Authors: Yanyan Zhou, Zihe Hu, Wenjing Jin, Haiyan Wu, Minghao Zuo, Changyu Shao, Yanhua Lan, Yang Shi, Ruikang Tang, Zhuo Chen, Zhijian Xie, Jue Shi
Journal: Advanced Healthcare Materials (2023)

Bone Regeneration In article 2201548 by Zhijian Xie, Jue Shi, and co-workers, a scaffold is designed based on the biomimetic mineralization theory, containing ultra-small particle size calcium phosphate nanoclusters (UsCCPs) with their 1–2 nm size. It can enhance bone strength characteristics by promoting intrafibrillar mineralization and promote the M2 type polarization of macrophages, thus forming an immune microenvironment conducive to osteogenesis and angiogenesis, thereby promoting the regeneration of rat calvaria.
Endogenous Electric Field‐Coupled PD@BP Biomimetic Periosteum Promotes Bone Regeneration through Sensory Nerve via Fanconi Anemia Signaling Pathway (Adv. Healthcare Mater. 12/2023)
Authors: Yanlin Su, Lian Zeng, Rongli Deng, Bing Ye, Shuo Tang, Zekang Xiong, Tingfang Sun, Qiuyue Ding, Weijie Su, Xirui Jing, Qing Gao, Xiumei Wang, Zhiye Qiu, Kaifang Chen, Daping Quan, Xiaodong Guo
Journal: Advanced Healthcare Materials (2023)

Biomimetic Periosteum In article 2203027 by Yanlin Su, Kaifang Chen, Daping Quan, Xiaodong Guo, and co-workers, [email protected] electroactive biomimetic periosteum is created, which can regulate the concentration of axon initial segments in sensory nerves, and promote bone regeneration by releasing neuropeptides. This will enrich the theory of neurogenic bone regeneration and provide a promising treatment for bone defects.
Extrafibrillarly Demineralized Dentin Matrix for Bone Regeneration (Adv. Healthcare Mater. 12/2023)
Authors: Xiaoyi Wu, Wenan Peng, Gufeng Liu, Shilei Wang, Bo Duan, Jian Yu, Hongye Yang, Cui Huang
Journal: Advanced Healthcare Materials (2023)

Extrafibrillar Demineralization In article 2202611 by Cui Huang, Hongye Yang, and co-workers, the extrafibrillar demineralization concept is introduced into the construction of tissue engineering scaffolds. The extrafibrillarly demineralized dentin facilitated mechanotransduction and osteogenic differentiation of stem cells, eventually brings about new ideas to develop hierarchical collagen-based biomaterials for bone regeneration.
Learning curve in pipeline embolization device: results from the pipeline embolization device in China post-market multicentre registry study
Authors: Junlin Lu, Yang Zhao, Hongqi Zhang, Tianxiao Li, Donglei Song, Sheng Guan, Aisha Maimaitili, Yunyan Wang, Wenfeng Feng, Yang Wang, Jieqing Wan, Guohua Mao, Huaizhang Shi, Xinjian Yang, Jianmin Liu, Yuanli Zhao
Journal: International Journal of Surgery (2023)

Intracranial aneurysms pose a significant health issue, affecting 3-5% of the adult population. The pipeline embolization device (PED) has emerged as a promising treatment for these lesions. This study aimed to investigate the impact of operator experience on complication and poor outcome rates, as well as the learning curve for PED.A total of 217 patients were consecutively enroled from four eligible centres and divided into three groups based on the number of procedures performed: group 1 (first 10 procedures), group 2 (11-20 procedures), and group 3(>20 procedures). Major complications include operation-related ischaemic or haemorrhagic events and mass effect deterioration. Poor outcome was defined as a modified Rankin Scale score greater than 2 at discharge. Cumulative summation (CUSUM) analysis was generated to assess the learning curve according to major complications and poor outcome.The study found that major complications and poor outcomes occurred in 5.1% and 2.3% of cases, respectively. The rate of major complications decreased from 10.0% in group 1 to 2.9% in group 3 ( P =0.053), while the rate of poor outcomes decreased from 7.5% in group 1 to 0.7% in group 3 ( P =0.015). Multivariable regression analysis adjusted for covariates showed that operator experience was associated with a lower rate of poor outcomes ( P =0.034). CUSUM analysis demonstrated that the learning curve for avoiding major complications and poor outcomes required 27 (mean=13) and 40 (mean=20) cases, respectively.These findings suggest that PED treatment requires a learning curve of 40 cases to achieve reproducibility regarding complications and functional results. Additionally, major complications and poor outcomes significantly decreases after the first 20 procedures. CUSUM analysis can serve as a useful tool for monitoring and assessing surgical performance.
Surgeons’ mental distress and risks after severe complications following radical gastrectomy in China: a nationwide cross-sectional questionnaire
Authors: Hongyong He, Chao Lin, Ruochen Li, Lu Zang, Xiao Huang, Fenglin Liu
Journal: International Journal of Surgery (2023)

This study was designed to investigate incidences of surgeons' mental distress following severe complications after radical gastrectomy.A cross-sectional survey was conducted between 1 June 2021 and 30 September 2021 among Chinese general and/or gastrointestinal surgeons who experienced severe complications after radical gastrectomy. The clinical features collected in the questionnaire included: (i) feeling burnout, anxiety, or depression; (ii) avoiding radical gastrectomy or feeling stress, slowing down the process during radical gastrectomy operations; (iii) having physical reactions, including heart pounding, trouble breathing, or sweating while recalling; (iv) having urges to quit being a surgeon; (v) taking psychiatric medications; and (vi) seeking psychological counselling. Analyses were performed to identify risk factors of severe mental distress, which was defined as meeting three or more of the above-mentioned clinical features.A total of 1062 valid questionnaires were received. The survey showed that most of the participating surgeons (69.02%) had at least one clinical feature of mental distress following severe complications after radical gastrectomy, and more than 25% of the surgeons suffered from severe mental distress. Surgeons from non-university affiliated hospitals, the junior surgeons, and existing violent doctor-patient conflicts were recognized as independent risk factors for surgeons' severe mental distress related to the severe complications after radical gastrectomy.About 70% of surgeons had mental health problems following severe complications after radical gastrectomy, and more than 25% of the surgeons suffered from severe mental distress. More strategies and policies are needed to improve the mental well-being of these surgeons after such incidences.
Classification of microvascular invasion of hepatocellular carcinoma: correlation with prognosis and magnetic resonance imaging
Authors: Yoon Jung Hwang, Jae Seok Bae, Youngeun Lee, Bo Yun Hur, Dong Ho Lee, Haeryoung Kim
Journal: Clinical and Molecular Hepatology (2023)

The microvascular invasion (MVI) of hepatocellular carcinoma (HCC) involves a wide histological spectrum, and it is unclear whether the degree of MVI correlates with patient prognosis or imaging findings. Here, we evaluate the prognostic value of MVI classification and analyze the radiologic features predictive of MVI.
The carbon footprint of ambulatory gastrointestinal endoscopy
Authors: Joël Lacroute, Juliette Marcantoni, Stéphane Petitot, Julien Weber, Patrick Levy, Bastien Dirrenberger, Irina Tchoumak, Mathilde Baron, Stéphanie Gibert, Sandrine Marguerite, Jérôme Huppertz, Olivier Gronier, Anne Derlon
Journal: Endoscopy (2023)

Endoscopy is considered the third highest generator of waste within healthcare. This is of public importance as approximately 18 million endoscopy procedures are performed yearly in the USA and 2 million in France. However, a precise measure of the carbon footprint of gastrointestinal endoscopy (GIE) is lacking.This retrospective study for 2021 was conducted in an ambulatory GIE center in France where 8524 procedures were performed on 6070 patients. The annual carbon footprint of GIE was calculated using "Bilan Carbone" of the French Environment and Energy Management Agency. This multi-criteria method accounts for direct and indirect greenhouse gas (GHG) emissions from energy consumption (gas and electricity), medical gases, medical and non-medical equipment, consumables, freight, travel, and waste.GHG emissions in 2021 were estimated to be 241.4 tonnes CO2 equivalent (CO2e) at the center, giving a carbon footprint for one GIE procedure of 28.4 kg CO2e. The main GHG emission, 45 % of total emissions, was from travel by patients and center staff to and from the center. Other emission sources, in rank order, were medical and non-medical equipment (32 %), energy consumption (12 %), consumables (7 %), waste (3 %), freight (0.4 %), and medical gases (0.005 %).This is the first multi-criteria analysis assessing the carbon footprint of GIE. It highlights that travel, medical equipment, and energy are major sources of impact, with waste being a minor contributor. This study provides an opportunity to raise awareness among gastroenterologists of the carbon footprint of GIE procedures.
Immunotherapy resistance driven by loss of NY-ESO-1 expression in response to transgenic adoptive cellular therapy with PD-1 blockade
Authors: Luke Frankiw, Arun Singh, Cole Peters, Begoña Comin-Anduix, Beata Berent-Maoz, Mignonette Macabali, Kiana Shammaie, Crystal Quiros, Paula Kaplan-Lefko, Ignacio Baselga Carretero, Antoni Ribas, Theodore Scott Nowicki
Journal: Journal for ImmunoTherapy of Cancer (2023)

The tumor antigen NY-ESO-1 has been shown to be an effective target for transgenic adoptive cell therapy (ACT) for the treatment of sarcoma and melanoma. However, despite frequent early clinical responses, many patients ultimately develop progressive disease. Understanding the mechanisms underlying treatment resistance is crucial to improve future ACT protocols. Here, we describe a novel mechanism of treatment resistance in sarcoma involving loss of expression of NY-ESO-1 in response to transgenic ACT with dendritic cell (DC) vaccination and programmed cell death protein-1 (PD-1) blockade.
The Src–ZNRF1 axis controls TLR3 trafficking and interferon responses to limit lung barrier damage
Authors: You-Sheng Lin, Yung-Chi Chang, Tai-Ling Chao, Ya-Min Tsai, Shu-Jhen Jhuang, Yu-Hsin Ho, Ting-Yu Lai, Yi-Ling Liu, Chiung-Ya Chen, Ching-Yen Tsai, Yi-Ping Hsueh, Sui-Yuan Chang, Tsung-Hsien Chuang, Chih-Yuan Lee, Li-Chung Hsu
Journal: The Journal of Experimental Medicine (2023)

Type I interferons are important antiviral cytokines, but prolonged interferon production is detrimental to the host. The TLR3-driven immune response is crucial for mammalian antiviral immunity, and its intracellular localization determines induction of type I interferons; however, the mechanism terminating TLR3 signaling remains obscure. Here, we show that the E3 ubiquitin ligase ZNRF1 controls TLR3 sorting into multivesicular bodies/lysosomes to terminate signaling and type I interferon production. Mechanistically, c-Src kinase activated by TLR3 engagement phosphorylates ZNRF1 at tyrosine 103, which mediates K63-linked ubiquitination of TLR3 at lysine 813 and promotes TLR3 lysosomal trafficking and degradation. ZNRF1-deficient mice and cells are resistant to infection by encephalomyocarditis virus and SARS-CoV-2 because of enhanced type I interferon production. However, Znrf1−/− mice have exacerbated lung barrier damage triggered by antiviral immunity, leading to enhanced susceptibility to respiratory bacterial superinfections. Our study highlights the c-Src–ZNRF1 axis as a negative feedback mechanism controlling TLR3 trafficking and the termination of TLR3 signaling.