tbuckley/cabot-search huggingface dataset:
This Will Kill You
Journal: JAMA (1952)

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Anaphylaxis from tolmetin
Authors: C. Restivo
Journal: JAMA (1978)

TOLMETIN SODIUM (Tolectin) is one of the newer nonsteroidal anti-inflammatory agents used in the management of rheumatoid arthritis. The package insert accompanying tolmetin includes many adverse effects of the drug, but there is no mention of anaphylactic shock induced by this agent. This report describes two patients in whom anaphylactic shock developed within 15 minutes of ingesting two 200-mg tolmetin sodium tablets. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 43-year-old woman was admitted to University of California at Los Angeles Hospital for anaphylactic shock. She had a three-year history of rheumatoid arthritis functional class 2, and met the American Rheumatism Association classification for definite rheumatoid arthritis. Previously, she had been treated with phenylbutazone. Gold sodium thiomalate therapy had been discontinued one year before admission because of severe generalized toxic dermatitis after a total of 260 mg had been given. Six months before admission, a facial rash had developed while taking 500
The University of Texas Medical Branch at Galveston. Origins and beginnings
Authors: C. R. Burns
Journal: JAMA (1991)

THOSE entering the east end of Galveston Island on the free ferry from Bolivar Peninsula soon encounter a large white water tower inscribed "Galveston Island—Home of UTMB." A quick glance reveals a cluster of tall buildings, some of the 70 structures that make up the campus of the University of Texas Medical Branch (UTMB). If arriving at night, they see a huge white-and-green—lit sign adorning one building: UTMB Galveston/John Sealy Hospital. How, some surely wonder, did this large health sciences center get established on this rather unlikely spot, a sandy barrier island in the northern Gulf of Mexico? <h3>QUEEN CITY OF THE GULF</h3> After Texas became a state in 1845, its population grew from around 200 000 in 1850 to more than 600 000 by 1860.<sup>1</sup>A hub of migrant and commercial bustle with more than 20 000 citizens, Galveston became the state's largest, wealthiest city by the mid-1870s.<sup>2</sup>
Therapia Hungarica, Budapest
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Catecholamines
Authors: Richard J. Wurtman
Journal: New England Journal of Medicine (1965)

Fate of Tissue CatecholaminesTissue norepinephrine may be released from sympathetic-nerve endings unchanged, or it may first be transformed within the nerve by the enzyme monoamine oxidase (MAO) (Fig. 12). Small amounts of "free" or "active" material are released spontaneously; more is liberated after sympathetic-nerve impulses.56,79 A tiny fraction of this "free" norepinephrine probably interacts with nearby receptor sites and has physiologic effects; the remainder is rapidly inactivated by O-methylation or rebinding within the nerve ending, or is washed away from its site of action by the circulation (Fig. 12).84 Most of the norepinephrine synthesized by the sympathetic-nerve endings never . . .
Treatment of thrombotic thrombocytopenic purpura with vincristine
Authors: L. A. Gutterman
Journal: JAMA (1982)

Five patients with thrombotic thrombocytopenic purpura (TTP) were treated with vincristine sulfate with reversal of all clinical and hematologic evidence of disease. In three patients, the diagnosis was confirmed by biopsy. Vincristine was the principal therapeutic agent in two patients. Remissions have been sustained without maintenance therapy for up to seven years. These observations suggest vincristine to be effective in the treatment of TTP. (<i>JAMA</i>1982;247:1433-1436)
THE HOSPITAL QUESTION.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ANTITUBERCULOSIS ORGANIZATION.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Judge Not...
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hispanic Kids Shoulder High Leukemia Burden
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CENTRAL SOCIETY FOR CLINICAL RESEARCH
Authors: Charles A. Doan
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: Vol. 65, No. 34
Authors: Kerry Souza, Raoul Guetiya W
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Venereum Cases Among Men Who Have Sex with Men -Michigan, August 2015-April 2016," on page 920, the first sentence of the third paragraph should have read, "During August 12, 2015-April 30, 2016, MDHHS received 38 reports of LGV all among MSM who were HIV-infected."
The relation of blood platelets to hemorrhagic disease. By W.W. Duke
Authors: W. W. Duke
Journal: JAMA (1983)

It is my purpose in this paper to report three cases and experiments which furnish additional evidence to show that the blood platelets play a part in stopping hemorrhage, and that one type of hemorrhagic disease may be attributed to an extreme reduction in the number of platelets. The cases possibly explain the relief which sometimes follows transfusion in hemorrhagic disease. It is my purpose also to describe a method for studying hemorrhage called the bleeding time, and to describe briefly a simple method for determining the coagulation time. In the cases there was marked hemorrhagic diathesis, a normal coagulation time, and almost an absence of platelets. Transfusion was performed in each case. After transfusion there was a marked increase in the number of platelets and remarkable relief of hemorrhage. When the platelet counts returned to their previous low level, hemorrhages returned. Later in the course of the disease in
EXTH-40. M011L-DEFICIENT ONCOLYTIC MYXOMA VIRUS INDUCES APOPTOSIS IN BRAIN TUMOR INITIATING CELLS AND ENHANCES SURVIVAL IN A NOVEL IMMUNOCOMPETENT MOUSE MODEL OF GLIOBLASTOMA
Authors: Peter Forsyth, Rajappa Kenchappa, Brienne McKenzie, Alexandra Pisklakova, Nam D. Tran, Grant McFadden
Journal: Neuro-Oncology (2016)

Myxoma virus (MYXV) is a promising oncolytic agent, highly effective against immortalized glioma cells but less effective against brain tumor initiating cells (BTICs), which are believed to mediate glioma development/recurrence. MYXV encodes various proteins to attenuate host cell apoptosis, including an anti-apoptotic Bcl-2 homologue known as M011L. Such proteins may limit the ability of MYXV to kill BTICs, which have heightened resistance to apoptosis. We hypothesized that infecting BTICs with an M011L-deficient MYXV construct would overcome BTIC resistance to MYXV. We used patient-derived BTICs to evaluate the efficacy of M011L knock-out virus (vMyx-M011L-KO) versus wild type MYXV (vMyx-WT) and characterized the mechanism of virally-induced cell death in vitro. To extend our findings in a novel immunocompetent animal model, we derived, cultured, and characterized a C57Bl/6J murine BTIC (mBTIC0309) from a spontaneous murine glioma and evaluated vMyx-M011L-KO efficacy with and without temozolomide (TMZ) in mBTIC0309-bearing mice. We demonstrated that vMyx-M011L-KO induces apoptosis in BTICs, dramatically increasing sensitivity to the virus. vMyx-WT failed to induce apoptosis, as M011L protein prevented Bax activation and cytochrome c release. In vivo, intracranial implantation of mBTIC0309 generated tumors that closely recapitulated the pathological and molecular profile of human gliomas. Treatment of tumor-bearing mice with vMyx-M011L-KO significantly prolonged survival in immunocompetent but not immunodeficient mouse models, an effect that is significantly enhanced in combination with TMZ. Our data suggest vMyx-M011L-KO is an effective, well-tolerated, pro-apoptotic oncolytic virus, and a strong candidate for clinical translation.
Rituximab In Allogeneic Hematopoietic Stem Cell Transplantation for Advanced Chronic Lymphocytic Leukemia with Fludarabine + Total Body Irradiation Conditioning: Results of a Phase II Prospective Multicenter Study (ITAC 02-02)
Authors: Mauricette Michallet, Mohamad Sobh, Stephane Morisset, Mohamad Mohty, Gerard Socie, Reza Tabrizi, Noel Milpied, Pierre Bordigoni, Nathalie Tedone, Jacques-Olivier Bay, Didier Blaise
Journal: Blood (2010)
437O KEYNOTE-024: Pembrolizumab (pembro) vs platinum-based chemotherapy (chemo) as first-line therapy for advanced NSCLC with a PD-L1 tumor proportion score (TPS) ≥50%
Authors: M. Reck, D. Rodríguez-Abreu, A. Robinson, R. Hui, T. Csoszi, A. Fülöp, M. Gottfried, N. Peled, A. Tafreshi, S. Cuffe, M.E. O'Brien, S. Rao, K. Hotta, M. Leiby, G. Lubiniecki, Y. Shentu, R. Rangwala, J. Brahmer
Journal: Annals of Oncology (2016)
Peroxisome mosaicism in the livers of peroxisomal deficiency patients*1
Authors: M ESPEEL
Journal: Hepatology (1995)

Peroxisomal deficiency disorders, which are genetically transmitted, are assumed to be expressed in all cells, and the use of cultured skin fibroblasts for diagnosis and research is based on this assumption. We describe three patients with clinical, biochemical, and microscopic evidence of a peroxisomal disorder. However, their liver displays mosaicism, i.e., parenchymal cells with peroxisomes are adjacent to cells without peroxisomes. Ten percent (volume), 8%, and less than 1% of the parenchyma possessed peroxisomes that can be identified in immunocytochemical tests for six matrix and membrane proteins performed by light and electron microscopy. In the bulk of the parenchyma, catalase is localized in the cytoplasm, and in such cells no peroxisomes are evident by electron microscopy and immunolabeling for the 43-kd peroxisomal membrane protein (PMP) in two patients; in the third case, peroxisomal membrane ghosts are present. Immunoblots of peroxisomal β-oxidation enzymes show a pattern similar to that from patients with a generalized peroxisomal deficiency. In contrast to the clinical and biochemical signs of peroxisomal dysfunction and hepatic histopathology, cultured fibroblasts from two patients demonstrate normal peroxisomal functions, including very-long-chain fatty acid oxidation and plasmalogen synthesis.
Literature and Medicine
Authors: Robert Coles
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correlation between Oncotype DX score with histologic grade, tumor size and Ki67 in patients with early stage breast cancer: A single academic institution experience.
Authors: Kate Ida Lathrop, Marcela Mazo- Canola, Jonathan Gelfond, Jay C Shiao, Barbara Hinojosa, Katherine A Terracina
Journal: Journal of Clinical Oncology (2015)

e11558 Background: Oncotype DX is an RT-PCR based assay that calculates a recurrence score (RS) to predict chemotherapy benefit in patients with breast cancer. Some authors have proposed using Ki-67, receptor status, Nottingham grade, and tumor size as histo-pathologic variables that could potentially substitute for the RS. Comprehensive and larger reviews are still lacking in this filed. To our knowledge this is the largest retrospective review of cases in a single academic institution. Aim: To describe, evaluate and compare the clinical and pathological characteristics of a cohort of consecutive patients diagnosed from 2007 to 2014 with breast cancer at the Cancer Therapy and Research Center, a designated NCI Cancer Center. Oncotype Dx was performed as part of standard of care for all patients in this analysis. Methods: We retrospectively reviewed and reported baseline patient demographic characteristics (including age, race and gender) and routine pathological features such as histologic grade, Ki-67, tumor size, and histologic type. All patients included in this study had an Oncotype Dx ordered between 2007 and 2014. Results: Our analysis included 252 patients of which 248 were females and 4 were males, median age was 56, median tumor size of 2.1 cm. The majority of cases were grade 2 with 49.4%, followed by grade 3 with 28.1% and grade one represented 22.5% of the sample. Ki-67 ranged from 2-98 %. Three variables correlated significantly with Oncotype Dx: tumor size (p = 0.0115), Ki-67 (p = 1.509e-09) and grade (p = 0.0307). Using these three variables together, the percentage of variance on the Oncotype Dx score was 0.35 (R2- coefficient of determination). Conclusions: While tumor size, grade and Ki-67 individually correlate significantly with Oncotype Dx score, taken together, they cannot reliably predict the RS. Also, the capability of these three factors to predict the RS decreases for tumors with high RS. Therefore, we conclude the RS can provide additional valuable information and should not be replaced by analysis of routine histologic variables alone.
HOUSE OF DELEGATES.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal