tbuckley/cabot-search huggingface dataset:
Recurrent Thiocyanate Intoxication, with Pancytopenia, Hypothyroidism and Psychosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Letters, Notes, and Answers to Correspondents
Authors: Mapperlev Glenberr, Donald Road, F Blenikini Vicar, Arthiur Charles, L Worthen, Rev Late, West Rector Of, Essex Hanninigfieldi, Mary To, Cariton-Le-Moorland Baldlock, Marsdeyn.-Oll Lincolinsliire, St Mary's, Scarborough, R1ev Bolland, George Roberts, George Maraden
Journal: BMJ (1888)

THz Manchester magistrates were engaged during two days4 recently in investigating charges against five men name(d Buchanan, Wilson, Nelson, Shires, and Thomas, wlho htad, it was alleged,.undervarious aliases, practised as "'melictal specialists," and defrauided a great number of peol)le of large sumis of moley.Some remarkable ei6dence was given as to the )rofits of the impostuire.The )risoners htave been committedl for trial at tlle sesions.AMBULANCE CLASSES FOn RAILWAY MEN.-Thirty-two of the London and Northt Western Railwaiy employgs belonging to the Birminglham Branclh of the St. Jolhn .Ambulance Association, were examined b)y Surgeonl-ajor hIutton, of Leamington, on Mlarclh 26th, and so satisfied the examiner as to receive htiglh comimicni- dation.Dn. FERrvEm.I Tos SANTOS, WhIO was sent to Paris by the Braziliani Government to stutdy the experiments of M. Pasteutr's laboratory has, we learin, been instrumental, in conjunction with Baron de Cotegipe, in promoting the establislhment of a Pasteur Institute at Rio de Janeiro.Sin Lyox PLAYFAIR lias been electe(d Chairman of tlie Com- mittee on the City of London Fire InqueAt Bill, which wouild enact that iiiquests shall be lheldl In all cases where flres of suis- picious origin halve led to fatal results.MEETINGS OF SOCIETIES DURING THE NEXT WEEK.TUE.4DAY.PATHOLOGICAL SoeCt'Y or Lox)s.N30 '.^r.
Acute pancreatitis: a complication of beta-blockade.
Journal: BMJ (1982)

potential routes for a multisynaptic itch reflex from the substantia to the nucleus of the trigeminal nerve in the medulla.The transmission of nerve impulses that give rise to a spinal reflex may be blocked by local anaesthesia.Our patients have not complained of itch since we added a small amount of bupivacaine to our intrathecal heroin preparation (1-0 mg freeze-dried heroin and 0-25 mg bupivacaine plain in 1-0 ml saline; pH 6-183, specific gravity 1-004 at 37°C).On this evidence an enkephalinergic reflex may well provide a credible alternative to histamine release as an explanation for facial itching associated with intraspinal administration of opiates.The reflex might be relayed at a central level by a medullary itch centre having a close functional link with the spinal nucleus of the trigeminal nerve.
Urban Birds
Authors: George N. Braman
Journal: Annals of Internal Medicine (2002)

Ad Libitum5 February 2002Urban BirdsGeorge N. Braman, MDGeorge N. Braman, MDBronx, NY 10471Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-3-200202050-00006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “They flee from me that sometime did me seek …”—Thomas Wyatt... Author, Article, and Disclosure InformationAffiliations: Bronx, NY 10471Corresponding Author: George N. Braman, MD, 6142 Delafield Avenue, Bronx, NY 10471. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 February 2002Volume 136, Issue 3Page: 191KeywordsBread ePublished: 5 February 2002 Issue Published: 5 February 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Alterations in Cyclic AMP Metabolism in Human Bronchial Asthma. II. LEUKOCYTE AND LYMPHOCYTE RESPONSES TO PROSTAGLANDINS
Authors: Charles W. Parker, Mary L. Baumann, Mary G. Huber
Journal: Journal of Clinical Investigation (1973)

In an effort to clarify the basis for the reduced cyclic AMP response to catecholamines in leukocytes and lymphocytes from asthmatic donors the response of these cells to prostaglandins has been examined. Cells with an impaired beta adrenergic response had an essentially unaltered response to prostaglandin E1 (PGE1) indicating the presence of selective beta adrenergic blockade. In contrast to what was observed with cells from asthmatic individuals, in normal control leukocytes with reduced catecholamine responsiveness PGE1 responses were usually reduced as well, suggesting a different mechanism. The excellent cyclic AMP response to PGE1 in cells from asthmatic donors would suggest that the defect in catecholamine responsiveness is at the level of the beta adrenergic receptor although a contributory role of altered substrate concentrations or increased phosphodiesterase activity is not formally excluded.
A Population-Based Twin Study of the Relationship Between Neuroticism and Internalizing Disorders
Authors: John Hettema
Journal: American Journal of Psychiatry (2006)

Objective: The anxiety and depressive disorders exhibit high levels of lifetime comorbidity with one another. The authors examined how genetic and environmental factors shared by the personality trait neuroticism and seven internalizing disorders may help explain this comorbidity. Method: Lifetime major depression, generalized anxiety disorder, panic disorder, agoraphobia, social phobia, animal phobia, situational phobia, and neuroticism were assessed in over 9,000 twins from male-male, female-female, and opposite-sex pairs through structured diagnostic interviews. Multivariate structural equation models were used to decompose the correlations between these phenotypes into genetic and environmental components, allowing for sex-specific factors. Results: Genetic factors shared with neuroticism accounted for between one-third and one-half of the genetic risk across the internalizing disorders. When nonsignificant gender differences were removed from the models, the genetic correlations between neuroticism and each disorder were high, while individual-specific environmental correlations were substantially lower. In addition, the authors could identify a neuroticism-independent genetic factor that significantly increased risk for major depression, generalized anxiety disorder, and panic disorder. Conclusions: There is substantial, but not complete, overlap between the genetic factors that influence individual variation in neuroticism and those that increase liability across the internalizing disorders, helping to explain the high rates of comorbidity among the latter. This may have important implications for identifying the susceptibility genes for these conditions.
How many doctors do we need? The tenth annual Duke Private Sector Conference
Authors: J. K. Iglehart
Journal: JAMA (1985)

LEADERS of American medicine are divided over whether the nation faces a future physician surplus as a consequence of federal policies that encouraged medical schools and teaching hospitals to increase their production of new physicians. When the subject of a possible surplus is discussed, as it was recently at the tenth annual Private Sector Conference, sponsored by Duke University, Durham, NC, approaches for dealing with the question revolve around calls for a sharp reduction in the number of foreign medical graduates (FMGs) and upgrading the quality of training and the rigor of monitoring physician performance, thus easing out of medicine marginal practitioners. Most conference participants viewed turning to government for solutions as a last resort, but one that practicing physicians would likely increasingly encourage at the state level in their search for relief from the enlarging pool of professional competitors. This year's conference, organized as it is annually by William
A PHYSICIAN POET.
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatic Failure in Malnutrition
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cognitive dissonance. The meaning of discordant imaging results
Authors: C. C. Jaffe
Journal: JAMA (1979)

THE PROLIFERATION of new medical imaging technology has led to a new problem in the interpretation of diagnostic findings—the occasional conflicting report in which only one of several imaging procedures demonstrates an abnormality in the same patient. When fewer imaging techniques were available and the clinical indications for each were more clearly defined, contradictory results were less common. Currently, a larger repertoire of imaging procedures is being used to search similar regions of the same patient for a suspected pathological condition. Each imaging modality—roentgenography, angiography, nuclear medicine, computerized tomography, and ultrasound—possesses unique degrees of sensitivity and specificity that have yet to be fully established for all clinical situations. As these multiple tests are employed for the same patient, conflicting results occasionally should be expected. How does this occur, and how is a clinician to resolve such a dilemma? Much early progress in medical imaging arose from modifications that improved the
P07.01 The CAR2BRAIN study: a monocentric phase I trial with ErbB2-specific NK-92/5.28.z cells in recurrent glioblastoma
Authors: M. C. Burger, I. C. Mildenberger, H. C. Cieplik, C. Zhang, L. Jennewein, K. Ihrig, M. Wagner, M. Mittelbronn, C. Senft, T. Tonn, W. S. Wels, J. P. Steinbach
Journal: Neuro-Oncology (2017)

Natural killer cells (NK cells) are increasingly explored for adoptive cancer immunotherapy. Like T cells, NK cells can be genetically modified to express chimeric antigen receptors (CARs) that recognize tumor-associated cell surface antigens and mediate selective recognition and specific lysis of cancer cells, thereby overcoming endogenous resistance mechanisms in tumor cells. In two previous phase I clinical trials, the continuously expanding human NK cell line NK-92 has been safely applied as an allogeneic cell therapeutic with clinical responses observed in some of the cancer patients treated. To enhance efficiency and specificity, the ErbB2-specific cell clone NK-92/5.28.z was generated, which carries a codon-optimized CAR (CAR 5.28.z) based on ErbB2-specific antibody FRP5 and CD28 and CD3ζ signaling domains. Elevated ErbB2 (HER2) protein levels have been reported in a significant proportion of GBM tumors and were correlated with impaired survival. In preclinical studies, we could demonstrate high and specific activity of NK-92/5.28.z cells against established and primary ErbB2-positive glioblastoma cells. In orthotopic xenograft models in ­immunodeficient mice ­repetitive intracranial injections of NK-92/5.28.z cells led to a highly extended symptom-free survival. In an immunocompetent mouse model, repetitive intratumoral NK-92/5.28.z injections induced an endogenous immune response against syngeneic GL261/ErbB2 glioblastomas. This resulted in tumor rejection and long-term protection against tumor rechallenge. Based on these promising data, we designed the CAR2BRAIN trial (EudraCT number 2016-00025-39), a monocentric phase I dose finding trial investigating the safety and tolerability of NK-92/5.28.z cells as an allogeneic cell therapeutic in patients with recurrent glioblastoma. The NK-92/5.28.z cells will be injected during relapse surgery into the resection wall (dose escalation cohort; 9–18 patients), and in a second patient group repetitively through a Rickham reservoir into the resection cavity (expansion cohort; 6 patients). In the dose escalation part of the trial the highest cell number which can be applied safely will be established (maximum tolerated dose = MTD) with a maximum dose of up to 1x10^8 cells planned. After determination of the MTD in the dose escalation cohort, in addition to the initial injection into the resection wall up to twelve further injections through the Rickham reservoir will be carried out to establish safety of prolonged treatment in the expansion cohort. Distribution of the injected NK-92/5.28.z cells in the brain, the cerebrospinal fluid and the blood will be monitored. Furthermore, the immune reaction triggered against the target antigen ErbB2 as well as ErbB2-independent immune reactions will be characterized.
Emerging and reemerging global microbial threats. Call for papers
Authors: M. A. Winker
Journal: JAMA (1995)

Ingenuity, knowledge, and organization alter but cannot cancel humanity's vulnerability to invasion by parasitic forms of life. Infectious disease which antedated the emergence of humankind will last as long as humanity itself, and will surely remain, as it has been hitherto, one of the fundamental parameters and determinants of human history. William H. McNeil,<i>Plagues and</i>Peoples, 1976<sup>1</sup> Four years ago, the National Institute of Allergy and Infectious Diseases reported that infectious diseases accounted for 25% of all physician visits in the United States.<sup>2</sup>Yet according to a 1992 Institute of Medicine report on emerging infections,<sup>3</sup>the public was relatively unaware of the growing threats to human health posed by microbial diseases, and even medical professionals underestimated the dangers to public health. The report concluded that a "small minority, mainly infectious disease specialists, have for years warned of the potential for serious epidemics and our lack of
Reply
Authors: James Hamilton, Svetlana Lutsenko
Journal: Hepatology (2016)

Potential conflict of interest: Nothing to report. Reply: Thank you for your interest in our article. Our studies in ATP7b–/– mice indicate that the genetic program regulating lipid metabolism is down‐regulated at 6 weeks of age. At this age, the mice have evidence of elevated hepatic copper, but liver disease has not yet developed.1 We were able to prevent the development of liver disease using the liver X receptor (LXR)/retinoid X receptor agonist, yet we did not affect hepatic copper (which remained high). We have not yet been able to definitively show how copper disrupts LXR‐mediated lipid metabolism in animals, but in vitro experiments have shown that copper can alter nuclear receptor signaling.2 The results you have presented are interesting. We certainly agree that patients with severe liver disease will have low cholesterol. There are many factors affecting serum lipid levels in children, which may account for the lack of correlation reported between copper levels and serum cholesterol. There are several published reports indicating that there is deranged lipid metabolism and low serum lipids in Wilson's disease (WD).3 We encourage you to submit your data for peer review so the WD community can learn from your experiences. We also agree that animal data must be scrutinized rigorously before applying the findings to humans. Even in mice, lipid metabolism is dependent upon multiple factors, such as age, sex, and disease stage. Nonetheless, we believe our research has shed new light onto the evolving paradigm for the pathogenesis of WD and may open new avenues for potential therapies.
Contents
Authors: Min Suh, Beong Yoo, Jung Kim, Yun Choi, Ki Park, Hee Kim, Yong Kim, Eun Lee, Tae-Woo Kim, Mijin Kim, Hyunjoong Kim, Atsuya Miki, Felipe Medeiros, Robert Weinreb, Sonia Jain, Feng He, Lucie Sharpsten, Naira Khachatryan, Na Ama Hammel, Jeffrey Liebmann, Christopher Girkin, Pamela Sample, Linda Zangwill, Stuart Gardiner, William Swanson, Deborah Goren, Steven Mansberger, Shaban Demirel, Lingam Vijaya, Asokan Rashima, Manish Panday, Nikhil Choudhari, Ve Ramesh, Velumuri Lokapavani, Devi Boddupalli, Govindan Sunil, Ronnie George, Dalia Said, Mohamed Elalfy, Zisis Gatzioufas, Ehab El-Zakzouk, Mansour Hassan, Mohamed Saif, Ahmed Zaki, Harminder Dua, Farhad Hafezi, Dana Robaei, Nicole Carnt, B Optom, Darwin Minassian, John Dart, Laura Contreras-Ruiz, Denise Ryan, Rose Sia, Kraig Bower, Darlene Dartt, Sharmila Masli, Muriel Schornack, Jeff Pyle, Sanjay Patel, Michael Ober, K Freund, Manthan Shah, Shareef Ahmed, Tamer Mahmoud, Thomas Aaberg, David Zacks, Hua Gao, Krishna Mukkamala, Uday Desai, Kirk Packo, Lawrence Yannuzzi
Journal: Ophthalmology (2014)
Culturally relevant communication interventions to promote voluntary blood donations in Ghana: an observational, interview-based study
Authors: Bernard Appiah, Imelda Bates, Shirley Owusu-Ofori, Alison Dunn
Journal: The Lancet Global Health (2013)

BackgroundAfrica has a yearly shortfall of 2 million units for blood transfusion. Many Africans have strong cultural and spiritual beliefs about blood and blood donation. We sought to identify culturally appropriate methods to encourage better communication between clinicians, the public, and journalists about blood donation and assessed social and cultural factors that might help the design of interventions to promote voluntary blood donations.MethodsWe recruited participants for this pilot study from three groups—clinicians, voluntary blood donors, and journalists—in Accra, Ghana. We recruited clinicians at Korle Bu Teaching Hospital and the National Blood Service through telephone calls and face-to-face contact. We recruited voluntary blood donors from a list available at the Korle Bu Teaching Hospital and contacted them by telephone. We recruited journalists by telephone from a group previously trained in health reporting. We did face-to-face interviews that lasted 15–45 min with four journalists, three blood donors, and three clinicians and two focus group discussions each with five participants representing all three groups, to identify recommendations for culturally appropriate communication strategies to promote blood donation, and social and cultural factors that might be important to communication interventions. The interviews and discussions were done in Autumn 2012, recorded, transcribed verbatim, and analysed for four key domains: communication channels, messages, approaches, and sociocultural factors.FindingsTo promote blood donations, study participants suggested establishing a common communication platform such as a newsletter or yearly meetings for the three groups; using social media to engage prospective younger blood donors, but not older donors; using mobile telephone ringing tones and radio or television drama about blood donations in English and local languages to engage both literate and illiterate populations; and media celebration of donors who achieve certain milestones.InterpretationOur study identifies opportunities for designing and targeting interventions that use a variety of culturally appropriate communication media. Such innovative approaches could increase blood donations and help to address blood shortages.FundingWellcome Trust.
THE TURKISH BATH.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal