POS0782 ULTRASONOGRAPHIC EVALUATION OF MAJOR SALIVARY GLANDS IN PRIMARY SJOGREN’S SYNDROME: COMPARISON OF THREE SCORING SYSTEMS AND ASSOCIATION WITH BIOPSY RESULTS.
Authors: C. Galisteo, S. Garcia-Cirera, S. Retamozo, M. Moreno, E. Casado, M. Rusiñol Gonzalez, J. Calvet, J. Gratacos-Masmitja
Journal: Annals of the Rheumatic Diseases (2022)

Background Salivary glands ultrasound is an imaging technique useful for primary Sjogren’s syndrome (pSS) diagnosis. Nowadays, the use of ultrasound in diagnostic criteria is not clear. Different scoring systems have been published in recent years. Objectives This study aims to compare the reliability between three salivary glands ultrasound (SGUS) scores in a series of patients with pSS. Furthermore, we assessed the association of the three SGUS scores with minor salivary gland biopsy. Methods A cross-sectional study including 98 subjects fulfilling the ACR-EULAR 2017 classification criteria for pSS. All patients underwent an ultrasound of the salivary glands and a minor salivary gland biopsy requested as per clinical practice. An experienced Rheumatologist in SGUS evaluated systematically the previously acquired images. This Rheumatologist classified the images using three different scoring systems obtained from the grades of bilateral parotid and submandibular glands: De Vita (0-3), Salaffi (0-4) and Omeract (0-3). These three scores were performed in different days and blinded for the previous scores results. SGUS grade ≥ 2 was considered positive. Positive biopsy was deemed when focus score ≥1. We evaluated the agreement between the three scores and the individual scores with respect to the biopsy. Results This study included 98 patients with pSS. The distribution of the different grades according to the score system and the percentage of a positive SGUS are shown in Table 1. The reliability for a positive score for the three evaluated systems was almost perfect, with a Light’s kappa of 0.95 [0.9-1] for the De Vita-Salaffi, 0.87 [0.77-0.97] for De Vita- Omeract and 0.83 [0.71-0.94] for Salaffi-Omeract. We observed a same degree of concordance when the individual parotid and submandibular scores were evaluated. There was only a fair agreement for positivity of SGUS and a positivebiopsy in all scoring systems, specifically De Vita (kappa = 0.27 [0.09-0.45]), Salaffi (kappa = 0.26 [0.06-0.45]) and Omeract (kappa = 0.22 [0.03-0.42]). This associations with a positive biopsy did not change in magnitude when individually evaluated parotid and submandibular glands. Table 1. Distribution of the ultrasound grades and the percentage of positive biopsy in the different scoring systems evaluated. 0 1 2 3 4 Positive score Vita 23 31 26 18 0 44 (23.5%) (31.6%) (26.5%) (18.4%) (44.9%) Salaffi 23 29 16 23 7 46 (23.5%) (29.6%) (16.3%) (23.5%) (7.1%) (46.69%) Omeract 27 29 23 16 0 39 (28.4%) (30.5%) (24.2%) (16.8%) (41.1%) Conclusion The three SGUS scores are reliable for the evaluation of the main salivary glands in pSS. There was only weak agreement for SGUS and biopsy, so these two techniques provides complementary information and currently, SGUS cannot replace the biopsy for diagnosis purposes. Disclosure of Interests None declared