tbuckley/cabot-search huggingface dataset:
A quantitative comparison of bone resection margin distances in virtual surgical planning versus histopathology: a prospective study
Authors: Jane J Pu, Anthony W I Lo, May C M Wong, Wing-Shan Choi, Grace Ho, Wei-Fa Yang, Yu-Xiong Su
Journal: International Journal of Surgery (2023)

Background: Positive bone margins have been shown to be associated with worse locoregional control and survival performance in oral oncology patients. With the application of computer-assisted surgery (CAS) and patient-specific surgical guides, we can accurately execute the preoperative osteotomy plan. However, how well we can predict the margin distance in the final histopathology with a preoperative CT scan, the factors associated with it, and how much leeway we should spare when designing the osteotomy planes during virtual surgical planning remain to be investigated. Materials and Methods: Patients from Jan 2021 to Dec 2022 with benign or malignant jaw tumors and with signs of bone marrow involvement in the preoperative CT scan in our center were prospectively recruited to the study. Virtual surgical planning (VSP) and measurement of the closest margin distance in the CT scan were performed by the single team of surgeons. The resection specimen was processed, and the margin distances were measured by a dedicated senior pathologist with the knowledge of orientation of the osteotomy planes. Results: A total of 35 patients were recruited, with 21 malignant and 14 benign cases. Sixty-eight bone margins were quantitatively analyzed. No significant difference in margin distances measured from the CT scan and final histopathology was detected ( P =0.19), and there was a strong correlation between the two (r s =0.74, P &lt;0.01). A considerable amount of variance was detected in the level of discrepancy between margin distances measured in CT scan and final histopathology (overall SD=6.26▓mm, malignancy SD=7.44▓mm, benign SD=4.40▓mm). No significant correlation existed between the two margin distances when only maxilla tumor margins were assessed ( P =0.16). Conclusion: Bone margin distance in VSP is reliably correlated to final pathological margin distance. A leeway distance of 15▓mm and 9▓mm should be considered when designing the osteotomy planes for malignancy and benign cases respectively. Extra attention should be paid to maxilla cases when pre-determining the osteotomy planes during virtual surgical planning.
Diagnostic capability of 18F-PSMA PET-MRI and pelvic MRI plus bone scan in treatment-naive prostate cancer: a single-center paired validating confirmatory study
Authors: Ziyun Qiao, Shuaidong Wang, Haiyan Wang, Biming He, Zhenkai Shi, Hai Zhou, Qiwei Yang, Xing Chen, Zhiwen You, Jun Zhao, Haifeng Wang
Journal: International Journal of Surgery (2023)

Background: Radical prostatectomy with pelvic lymph node dissection for the treatment of high-risk localized prostate cancer (PCa) results in long-term benefits in selected patients. But insufficient sensitivity of conventional examinations which are pelvic MRI and bone scan, limits the diagnosis of bone and lymph node metastasis of PCa. This affects the surgical management strategy of a large number of patients. The purpose of this study was to investigate whether 18F-prostate-specific membrane antigen (PSMA) positron emission tomography (PET)-magnetic resonance imaging (MRI) could improve the clinical detection of PCa metastases compared with the conventional pelvic MRI plus bone scan. Materials and Methods: From April 2020 to April 2023, we prospectively enrolled 472 patients with histologically proven PCa in our center, and 120 patients underwent 18F-PSMA PET-MRI, multiparametric MRI (mpMRI), and bone scan before laparoscopic radical prostatectomy plus lymph node dissection. The accuracy of imaging results in detecting lymph node and bone metastatic lesions was compared between PSMA PET-MRI and MRI plus bone scan. Results: In diagnosing lymph node metastasis, PSMA PET-MRI had an area under the curve (AUC) of 0.844 (95% confidence intervals [CI]: 0.738–0.949, P &lt; 0.001), sensitivity and specificity of 75% and 96%, which performed apparently better than MRI (AUC=0.615 [95% CI: 0.480–0.750, P =0.073]). PSMA PET-MRI showed excellent expression in the diagnosis of bone metastases, with an AUC of 0.910 (95% CI: 0.840–0.981, P &lt;0.001) compared to 0.700 (95% CI: 0.577–0.823, P =0.001) in bone scanning. PSMA PET-MRI also had higher sensitivity than bone scanning (90% vs. 43%), while lower specificity (92% vs. 97%). Conclusion: PSMA PET-MRI is superior to conventional imaging at diagnosing metastases in lymph nodes and bones in PCa and can provide a more accurate stagement.
Low-molecular-weight heparin is associated with lower venous thromboembolism events than factor Xa inhibitors in patients with severe blunt trauma: a cohort study from the Trauma Quality Improvement Program
Authors: Sheng-Yu Chan, Jen-Fu Huang, Chi-Tung Cheng, Chih-Po Hsu, Chien-Hung Liao, Chih-Yuan Fu
Journal: International Journal of Surgery (2023)

Background: Venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism (PE), is a common complication of major trauma. Pharmacological VTE prophylactics are widely used, and low-molecular-weight heparin (LMWH) is recommended. Factor Xa inhibitors are increasingly being used for VTE prophylaxis in both medical and surgical patients. Evidence comparing LMWH and factor Xa inhibitors as VTE prophylactics for severe blunt trauma is lacking. This study aims to compare the efficacy and safety of factor Xa inhibitors and LMHW in VTE prophylaxis. Materials and Methods: Patients with severe blunt trauma who received LMWH or a factor Xa inhibitor for VTE prophylaxis in the Trauma Quality Improvement Program between 2017 and 2019 were included. The comparison was performed after using propensity score matching. The outcomes included mortality and incidence of DVT, PE, post-prophylactics hemorrhage control procedures and length of stay. Results: After 2:1 propensity score matching, 1,128 patients (n=752, LMHW group; n=376, factor Xa inhibitor group) were included in the analysis. Patients in the LMWH group had fewer VTE events than those in the factor Xa inhibitor group (DVT, 3.7% vs. 7.2%, P =0.013; PE, 0.4% vs. 3.2%, P &lt;0.001). VTE risk was higher in the factor Xa group (DVT: odds ratio [OR], 1.97; 95% confidence interval [95%CI], 1.12–3.44; P =0.018 and PE: OR, 9.65; 95%CI, 2.91–44.12; P =0.001). The mortality rate was higher in the LMWH group; however, there was no significant difference (4.0% vs. 1.9%; P =0.075). The difference in the risk of undergoing hemorrhage control surgery after VTE prophylaxis between both groups was insignificant (0.3% vs. 0.0%; P =0.333). Conclusions: LMWH was associated with a lower risk of VTE than factor Xa inhibitors in patients with severe blunt trauma. The mortality rate was higher in the LMWH group; however, there was no statistically significant difference observed.
A response to ‘A commentary on “Detection of cancer cells and tumor margins during colorectal cancer surgery by intraoperative flow cytometry”’
Authors: Christina Bali, Vaia K. Georvasili, Michail Mitsis, George Vartholomatos, Georgios S. Markopoulos
Journal: International Journal of Surgery (2023)

Bali, Christina; Georvasili, Vaia K.; Mitsis, Michail; Vartholomatos, George; Markopoulos, Georgios S. Author Information
Commentary on ‘the review on the progress in the surgical treatment of sacrococcygeal pilonidal sinus’
Authors: Hongru Sun, Dengfeng Yu
Journal: International Journal of Surgery (2023)

Department of General Surgery, Dalian University Affiliated Xinhua Hospital, Dalian 116021, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article Published online ■ ■ *Corresponding author. Address: Department of General Surgery, Dalian University Affiliated Xinhua Hospital, No. 156 Wansui Street, Shahekou District, Dalian, Liaoning 116021, China. E-mail address: [email protected] (D-F Yu). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Comparison of two different methods for lymphadenectomy along the left recurrent laryngeal nerve by minimally invasive esophagectomy in patients with esophageal squamous cell carcinoma: a prospective randomized trial
Authors: Ying-Jian Wang, Xian-Dong He, Yi-Qiu He, Tao Bao, Xian-Feng Xie, Kun-Kun Li, Wei Guo
Journal: International Journal of Surgery (2023)

Background: Lymph nodes along the left recurrent laryngeal nerve (LRLN) is thought to be highly involved in esophageal cancer. Given the unique anatomical positioning of the nerve, performing lymphadenectomy in this region requires advanced techniques within limited working space. Meanwhile, high incidence of morbidity and mortality is associated with lymphadenectomy. Although several methods have been applied to reduce the technical requirement and the incidence of postoperative complication, the optimal method remains controversial. Methods: This study was a single-center, prospective, randomized trial to investigate the utility of lymphadenectomy along the LRLN during the minimally invasive esophagectomy (MIE) in esophageal squamous cell carcinoma (ESCC) patients by comparing the surgical outcome, postoperative complication, survival rate and quality of life (QoL) between the retraction method (RM) and the suspension method (SM) in patients with esophageal cancer from June 2018 to November 2020. QoL was assessed according to questionnaire: EQ-5D-5L. Results: Of 94 patients were enrolled and randomized allocated to RM and SM group equally. Characteristics did not differ between groups. The duration of lymph node dissection along LRLN was significant longer in SM group ( P &lt;0.001). No difference was observed about postoperative complications. One of in-hospital death was occurred in each group ( P &gt;0.999). Patients in neither of groups exhibiting difference about 3-year disease free survival rate ( P =0.180) and overall survival rate ( P =0.430). No difference was observed in postoperative QoL between groups at different time points (all, P &gt;0.05). Conclusion: Both methods of lymph node dissection along the LRLN during MIE in ESCC patients are technically feasible and safe. The RM appears more favorable in terms of reducing surgical duration compared to the SM.
Development of a continuously perfused ex vivo kidney training model for laparoscopic partial nephrectomy: validity and efficiency
Authors: Huijian Zhang, Jun Wang, Chundong Liu, Bingran Du, Jujiao Xiao, Lei Qian, Qun Zhang, Jianyi Li
Journal: International Journal of Surgery (2023)

Background: Suture hemostasis is essential for laparoscopic partial nephrectomy (LPN). This study aimed to develop, validate, and test the efficacy of a continuously-perfused training model (CPTM) in LPN with high-level simulated bleeding. Materials and Methods: The CPTM was constructed using fresh porcine kidneys with renal arteries continuously perfused with red-dyed liquid gelatin. Twenty-nine participants with expert, intermediate, or novice laparoscopic experience levels were recruited. The expert and intermediate participants evaluated the CPTM, and the novice participants were randomly assigned to one of two groups to complete training on a CPTM or dry box training model (DBTM). Messick’s framework criteria were utilized to assess the validity and training efficacy of the model. The data were analyzed using the Mann–Whitney U, Kruskal–Wallis, and Friedman tests. A value of P&lt; 0.05 was considered statistically significant. Results: Positive comments were provided by all experts and intermediates for the Content . The Relationships with other variables demonstrated significant differences among novices, intermediates, and experts in all metrics ( P&lt; 0.05). The Consequences showed that the CPTM helped novices acquire LPN skills. The training efficacy was significantly better than that of the DBTM ( P&lt; 0.05). There were no significant differences between the final performances of the novices and initial performances of the experts ( P &gt;0.05). Synthesizing all metrics, the LPN skills learned using CPTMs were significantly improved in the 12th round of training. Conclusion: The CPTM offered high-level simulation of bleeding with realistic tissue texture for acquiring LPN skills. Training of no fewer than 12 rounds is recommended for a novice’s LPN training on the CPTM.
Preparation, Properties, and Bioapplications of Block Copolymer Nanopatterns
Authors: Raul Fontelo, Rui L. Reis, Ramon Novoa‐Carballal, Iva Pashkuleva
Journal: Advanced Healthcare Materials (2023)

Block copolymer (BCP) self-assembly has emerged as a feasible method for large-scale fabrication with remarkable precision - features that are not common for most of the nanofabrication techniques. In this review, recent advancements in the molecular design of BCP along with state-of-the-art processing methodologies based on microphase separation alone or its combination with different lithography methods are presented. Furthermore, the bioapplications of the generated nanopatterns in the development of protein arrays, cell-selective surfaces, and antibacterial coatings are explored. Finally, the current challenges in the field are outlined and the potential breakthroughs that can be achieved by adopting BCP approaches already applied in the fabrication of electronic devices are discussed.
Regional analgesia techniques for lumbar spine surgery: a frequentist network meta-analysis
Authors: Guanyi Liu, Jichong Ying
Journal: International Journal of Surgery (2023)

Department of Orthopedics, Ningbo No.6 Hospital, Ningbo, Zhejiang, 315040, People's Republic of China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Orthopaedics, Ningbo No. 6 Hospital, 1059 Zhongshan East Road, Ningbo, Zhejiang, 315040, People's Republic of China. E-mail address: [email protected] (Q. Ying). This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0/
Clinicopathological features and prognosis of synchronous and metachronous colorectal cancer: a retrospective cohort study
Authors: Hao Fan, Rongbo Wen, Leqi Zhou, Xianhua Gao, Zheng Lou, Liqiang Hao, Ronggui Meng, Haifeng Gong, Guanyu Yu, Wei Zhang
Journal: International Journal of Surgery (2023)

To investigate the clinicopathological features and prognosis of synchronous and metachronous multiple primary colorectal cancer.
A commentary on ‘Minimally invasive versus open total pancreatectomy: a systematic review and meta-analysis’
Authors: Zhichao Chen, Yonghua Lin
Journal: International Journal of Surgery (2023)

aMaster of Medicine, Hepatological Surgery Department, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China bDoctor of Medicine, Hepatological Surgery Department, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article Published online ■ ■ *Corresponding author. Address: Doctor of Medicine, Hepatological Surgery Department, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China, E-mail address: [email protected] (Y. Lin). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Commentary on ‘Potential of nanoemulsions for accelerated wound healing: innovative strategies’
Authors: Ilham Ben Amor, Soumeia Zeghoud, Ali Alnazza Alhamad
Journal: International Journal of Surgery (2023)

aDepartment of Process Engineering and Petrochemical, Faculty of Technology, University of El Oued, El Oued 39000, Algeria bRenewable Energy Development unit in Arid Zones (UDERZA), University of El Oued, El Oued 39000, Algeria cDepartment of Chemistry, Faculty of Science, University of Aleppo, Syria Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: University of Aleppo Aleppo, SYRIAN ARAB REPUBLIC. E-mail address: [email protected] (A. Alnazza Alhamad). This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-nc-sa/4.0/
Glioma Response to IDH Inhibition: Real-World Experience
Authors: Rimas V. Lukas, Craig Horbinski
Journal: Clinical Cancer Research (2023)

Summary Treatment of IDH-mutated non-enhancing grade 2 and 3 diffuse gliomas with ivosidenib leads to reduction of tumor size when assessed via volumetric MRI. Isocitrate dehydrogenase inhibition has a therapeutic benefit in patients with these tumors. See related article by Kamson et al., p. 4863
An Analysis of Delayed Bleeding in Cases of Colorectal Endoscopic Submucosal Dissection Due to Types of Direct Oral Anticoagulants in Japan
Authors: Naohisa Yoshida, Yoshikazu Hayashi, Daichi Togo, Shiro Oka, Kazunori Takada, Shusei Fukunaga, Yoshinori Morita, Takemasa Hayashi, Kazuhiro Kozuka, Yosuke Tsuji, Takashi Murakami, Takeshi Yamamura, Yoriaki Komeda, Yoji Takeuchi, Kensuke Shinmura, Hiroko Fukuda, Shinji Yoshii, Shoko Ono, Shinichi Katsuki, Kazumasa Kawashima, Daiki Nemoto, Hiroyuki Yamamoto, Yutaka Saito, Naoto Tamai, Aya Iwao, Yuki Itoi, Shigetsugu Tsuji, Yoshikazu Inagaki, Yutaka Inada, Koichi Soga, Daisuke Hasegawa, Takaaki Murakami, Hiroyuki Yoriki, Kohei Fukumoto, Takayuki Motoyoshi, Yasuki Nakatani, Yasushi Sano, Mikitaka Iguchi, Shigehiko Fujii, Hiromitsu Ban, Keita Harada, Koichi Okamoto, Hitoshi Nishiyama, Fumisato Sasaki, Kazujhiro Mizukami, Takashi Shono, Ryo Shimoda, Tadashi Miike, Naoyuki Yamaguchi
Journal: Clinical Gastroenterology and Hepatology (2023)
Hydroxyapatite‐Coated Small Intestinal Submucosa Membranes Enhanced Periodontal Tissue Regeneration through Immunomodulation and Osteogenesis via BMP‐2/Smad Signaling Pathway
Authors: Guoping Cheng, Shujuan Guo, Maoxue Li, Shimeng Xiao, Bo Jiang, Yi Ding
Journal: Advanced Healthcare Materials (2023)

Periodontitis, a chronic infection causing periodontal tissue loss, may be effectively addressed with in situ tissue engineering. Small intestinal submucosa (SIS) offers exceptional biocompatibility and biodegradability but lacks sufficient osteoconductive and osteoinductive properties. This study develops and characterizes SIS coated with hydroxyapatite (SIS-HA) and gelatin methacrylate hydroxyapatite (SIS-Gel-HA) using biomineralization and chemical crosslinking. The impact on periodontal tissue regeneration is assessed by evaluating macrophage immune response and osteogenic differentiation potential of periodontal ligament stem cells (PDLSCs) in vitro and rat periodontal defects in vivo. The jejunum segment, with the highest collagen type I content, is optimal for SIS preparation. SIS retains collagen fiber structure and bioactive factors. Calcium content is 2.21% in SIS-HA and 2.45% in SIS-Gel-HA, with no significant differences in hydrophilicity, physicochemical properties, protein composition, or biocompatibility among SIS, SIS-HA, SIS-Gel, and SIS-Gel-HA. SIS is found to upregulate M2 marker expression, both SIS-HA and SIS-Gel-HA enhance the osteogenic differentiation of PDLSCs through the BMP-2/Smad signaling pathway, and SIS-HA demonstrates superior in vitro osteogenic activity. In vivo, SIS-HA and SIS-Gel-HA yield denser, more mature bones with the highest BMP-2 and Smad expression. SIS-HA and SIS-Gel-HA demonstrate enhanced immunity-osteogenesis coupling, representing a promising periodontal tissue regeneration approach.
A Proofreading Mutation with an Allosteric Effect Allows a Cluster of SARS-CoV-2 Viruses to Rapidly Evolve
Authors: Andrew H Mack, Georgina Menzies, Alex Southgate, D Dafydd Jones, Thomas R Connor
Journal: Molecular Biology and Evolution (2023)

The RNA-dependent RNA polymerase of the severe acute respiratory syndrome coronavirus 2 virus is error prone, with errors being corrected by the exonuclease (NSP14) proofreading mechanism. However, the mutagenesis and subsequent evolutionary trajectory of the virus is mediated by the delicate interplay of replicase fidelity and environmental pressures. Here, we have shown that a single, distal mutation (F60S) in NSP14 can have a profound impact upon proofreading with an increased accumulation of mutations and elevated evolutionary rate being observed. Understanding the implications of these changes is crucial, as these underlying mutational processes may have important implications for understanding the population-wide evolution of the virus. This study underscores the urgent need for continued research into the replicative mechanisms of this virus to combat its continued impact on global health, through the re-emergence of immuno-evasive variants.