tbuckley/cabot-search huggingface dataset:
POS1284 PAINFUL CERVICAL INVOLVEMENT AND FEBRILE TORTICOLLIS: A FREQUENT SYMPTOM OF PIMS
Authors: A. Schvartz, R. Kechiche, F. Bajolle, S. Poignant, R. Basmaci, C. Pajot, I. Melki, L. Morin, C. Adamsbaum, N. Matsa, M. Hofer, I. Koné-Paut, C. Galeotti
Journal: Annals of the Rheumatic Diseases (2022)

Background Pediatric Inflammatory Multisystemic Syndrome associated to SARS-CoV2 (PIMS) happens 4 to 6 weeks after SARS-CoV2 infection 1-2 . Its early diagnostic recognition as well as its early management is important to avoid cardiac complications related to this pathology. Objectives To highlight a frequent symptom in PIMS and improve its therapeutic care. Methods The JIR Cohort database, an international registry collecting data on patients with pediatric inflammatory diseases, was consulted to include patients between 03/15/20 and 12/31/2021. Results Of the 140 patients in whom a diagnosis of PIMS was retained, we present a series of 38 patients (27%) who presented at diagnosis or during evolution, febrile torticollis or painful cervical involvement. These patients were on average 8.2 years old (0.6-15.2). The proportion of boys was 14 out of 38 (37%). Twenty-four patients out of 33 (73%) were hospitalized in intensive care. Ten patients out of 38 (26%) underwent cervical imaging, 5 (50%) had abnormalities such as collection or infiltration of the soft tissues. At the therapeutic level, 27/38 patients (71%) received corticosteroid therapy, 33/38 (87%) immunoglobulins, and 26/38 (68%) antibiotic therapy. Conclusion PIMS is a pathology with significant clinical heterogeneity and severe consequences in case of delay in therapeutic management. In this epidemic context, it is important to consider PIMS in any patient with febrile torticollis, especially if he does not respond to antibiotics. References [1]Feldstein LR, Rose EB, Horwitz SM, Collins JP, Newhams MM, Son MBF, et al. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N Engl J Med. 23 juill 2020. [2]Whittaker E, Bamford A, Kenny J, Kaforou M, Jones CE, Shah P, et al. Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2. JAMA. 8 juin 2020 Disclosure of Interests None declared
AB0942 INVOLVEMENT OF THE FOOT IN PSORIATIC ARTHRITIS. A REVIEW OF 55 CASES.
Authors: F. E. Bennani, M. M. Pamela Chardene, A. Mougui, I. El Bouchti
Journal: Annals of the Rheumatic Diseases (2022)

Background Psoriatic arthritis (PsA) is a chronic inflammatory rheumatic disease belonging to the spondyloarthritis family with which it shares many clinical and radiographic features. The involvement of the feet with an asymmetric distribution of arthritis is very specific to Psoriasis. Objectives The objective of our study is to determine the frequency of foot involvement in a population of psoriatic arthritis by detailing the clinico-radiological aspect of the foot. Methods Retrospective descriptive study carried out on the files of patients hospitalized for psoriatic arthritis over a period of 9 years from January 2013 to December 2021. For each file, we collected epidemiological, clinical and radiological data. Results 55 patients were included: 41 women (74.5%) and 14 men (25.5%). The mean age was 48.81 ±17.08 years [20-85 years]. Personal and family history of skin psoriasis was noted in twenty and one patients, respectively. The average duration of evolution was about 5.5 years. Inflammatory talalgia was noted in 34 patients (61.8%) and forefoot involvement was found in 13 cases (23.6%). Sausage toe was noted in three cases (5.5%). None of the patients had Bauer’s toe or psoriatic onychopachydermoperiostitis of the great toe. The radiographic workup showed calcaneitis in 34.5% (n=30), osteoperiostitis of the great toe in 6 patients (10.9%). According to the radiological criteria fingers-toes or (CRDO), 3 patients had juxta articular periostitis (5.5%), two cases of phalangeal tuft resorption (3.6%) and one case of osteolysis of an interphalangeal joint (1.8%). Conclusion In our context, the involvement of the foot during psoriatic arthritis is dominated clinically and radiologically by the involvement of the hindfoot. The importance of the classification criteria for Psoriasis cannot be undermind, and aim is improving their sensitivity and specificity. References [1]Lioté F, Frazier A, Quemeneur A, Ea H. Le pied et la cheville des spondyloarthrites. Revue du Rhumatisme Monographies. 2014 Apr; 81(2):115-9. [2]Bezza A, Niamane R, Amine B, El Maghraoui A, Bensabbah R, Hajjaj-Hassouni N. L’atteinte du pied au cours du rhumatisme psoriasique. À propos de 26 cas. Revue du Rhumatisme. 2004 Dec;71(12):1155-8. [3]Fournié B. Les atteintes digitales du rhumatisme psoriasique. Rhumatologie 1996;48:103–5. Disclosure of Interests None declared
AB1096 THE INFLUENCE OF THE BEHAVIORAL RESTRICTION OF COVID-19 PANDEMIC FOR THE FRAILTY OF PATIENTS WITH RHEUMATOID ARTHRITIS
Authors: M. Tada, Y. Yamada, K. Mandai, Y. Matsumoto, N. Hidaka
Journal: Annals of the Rheumatic Diseases (2022)

Background We previously reported the prevalence of frailty and relation of disease activity at patients with rheumatoid arthritis (RA) 1 . The behavioral restriction of COVID-19 pandemic influenced for the lifestyle of people included patients with RA. Objectives The relationship between the behavioral restriction of COVID-19 pandemic and frailty was investigated. Methods We used the date from prospective observational study (CHIKARA study: UMIN000023744). 70 from 100 patients with RA were followed-up and evaluated the frailty and subcategories (social, physical, mental, nutrition, and cognitive) by frailty checklist. The prevalence of frailty and the change of exercise and daily life activities by visual analog scale were investigated at pre- and post-behavioral restriction. The correlation of frailty and change of amount of exercise and daily life activity examined by univariate analysis. Results Mean age was 69.7 years (women n=57, men n=13). The prevalence of frailty at post-behavioral restriction increased compared that at pre-behavioral restriction (post:35.8% vs pre:30.0%). Especially, cognitive and total score at post-behavioral restriction increased significantly. The rate of decrease of exercise by &lt;25%, 26~50%, and 51%&lt; were 70%, 21%, and 9%, respectively (mean:20% decrease). Whereas, the rate of decrease of daily life activities by &lt;25%, 26~50%, and 51%&lt; were 37%, 27%, and 36%, respectively (mean:44% decrease). The change of exercise was significantly negatively correlated with the change of nutrition (R=-0.245, P=0.041) at Table 1. There was no correlation between the change of daily life activities and subcategories. Table 1. Univariate analysis of the changes in daily living activities or exercise and those in frailty and subcategories Change of daily living activities Change of exercise R value P value R value P value Δ Social 0.099 0.417 -0.006 0.962 Δ Physical 0.182 0.130 -0.005 0.965 Δ Mental -0.200 0.097 -0.234 0.051 Δ Nutrition -0.204 0.091 -0.245 0.041 Δ Cognitive -0.087 0.476 -0.034 0.778 Δ Total -0.091 0.454 -0.178 0.140 Δ, change from pre- to post-behavioral restriction. Analyzed by Spearman’s rank correlation coefficient Conclusion The exercise slightly decreased and the daily life activities decreased almost 50% by the behavioral restriction of COVID-19 pandemic. The prevalence of frailty increased 5.8%, and cognitive and total score were significantly high at post-behavioral restriction of COVID-19 pandemic. The decrease of exercise correlated with the worse of nutrition. References [1]Tada M, Yamada Y, Mandai K, Hidaka N. Correlation between frailty and disease activity in patients with rheumatoid arthritis: Data from the CHIKARA study. Geriatr Gerontol Int 2019; 19:1220-5. Disclosure of Interests None declared
POS0923 EXTRACELLULAR VESICLES AS POTENTIAL BIOMARKERS OF EARLY DISEASE STAGE IN SYSTEMIC SCLEROSIS
Authors: J. Colic, I. Pruner, N. Damjanov, J. Antovic, M. Sefik Bukilica, A. Antovic
Journal: Annals of the Rheumatic Diseases (2022)

Background Extracellular vesicles (EVs) are membrane-coated vesicles most often generated from the vasculature and circulating blood cells upon cell activation and during the early phase of apoptosis (1). Objectives To evaluate the concentration of different subpopulations of EVs in plasma from patients with SSc in relation to the disease duration and to the markers of endothelial injury. Methods Our study included 59 SSc patients (36 limited (lSSc) and 23 diffuse cutaneous subset (dSSc)) and 46 healthy age and gender matched controls subjects. Disease duration less than 3 years in patients with dSSc and less than 5 years in those with lSSc was considered as early disease stage. Clinical evaluation of patients was performed. EVs were analysed with flow cytometry after staining platelet poor plasma with fluorescent cell-specific monoclonal antibodies. The concentration of following phosphatidylserine-positive EVs (PS+ EVs) were analyzed: total EVs, endothelial EVs (EEVs; CD144+), platelet EVs (PEVs; CD42b+), monocytes EVs (LEVs; CD14+), EVs expressing ICAM1 (CD54+), VCAM1 (CD106+) and P selectin (CD62p+). Serum levels of ICAM1, VCAM1 and P selectin were determined with ELISA. Results Median disease duration of our cohort was 4 (0-29) years (early lSSc [20/36]: 2.5 (0-4.5) years; early dSSc [11/23]: 10 (1-30) months). All types of investigated EVs were significantly elevated in SSc patients compared to controls (p&lt;0.05). Patients with early disease stage had significantly increased levels of all PS+EVs compared to HC (p&lt;0.05). Moreover, the levels of EVs expressing ICAM1 and VCAM1 showed good validity in identifying patients with early disease stage (AUC 0.7, p&lt;0.01). PEVs were increased in early dSSc compared to early lSSc, but the difference did not reach statistical significance (p=0.07). There was a correlation between serum levels and the levels of EVs expressing specific adhesion molecules (ICAM1: r=0.7, p&lt;0.01; VCAM1: r=0.7, p&lt;0.01; P selectin: r=-0.7, p&lt;0.01), only within the group with early dSSc subtype of the disease. Further correlations were detected between ICAM1+EVs with either mRSS (r=0.07, p&lt; 0.01) or EUSTAR activity index (r=0.07, p= 0.02) among patients with early dSSc. Conclusion Increased levels of circulating EVs of different cell origin were present in patients with early SSc. EVs expressing either ICAM1 or VCAM1 could be novel biomarkers of early disease. EVs expressing ICAM1 showed association with severity of skin involvement and disease activity in patients with early dSSc giving insight into their role in the pathogenesis of SSc. References [1]J Colic, M Matucci-Cerinic, S Guiducci and N Damjanov. Review: Microparticles in systemic sclerosis, targets or tools to control fibrosis: This is the question!. Journal of Scleroderma and Related Disorders. 2019; 5(34):239719831985735 Disclosure of Interests None declared
AB1538-HPR AMIGOS DE FIBRO (FIBRO FRIENDS): VALIDATION OF AN EDUCATIONAL PROGRAM TO PROMOTE THE HEALTH OF PATIENTS WITH FIBROMYALGIA IN BRAZIL.
Authors: M. Antunes, A. Schmitt, A. Pasqual Marques
Journal: Annals of the Rheumatic Diseases (2022)

Background Health education is a very important tool in the treatment of people with fibromyalgia. Health education acts as an excellent non-pharmacological treatment to promote health in fibromyalgia. Objectives To validate a multidisciplinary educational program to promote the health of people with fibromyalgia in Brazil, called Amigos de Fibro. Methods This is a methodological research with 45 individuals with fibromyalgia (target audience) and 23 health professionals (expert judges). Both groups used an instrument to assess the objectives, themes and proposed actions, relevance, writing style and structure of the program using the Delphi technique. The Content Validity Index (CVI) ≥ 0.78 and Kappa Coefficient ≥ 0.61 were used to analyze and validate the data. Results All items evaluated in both groups had a considerable minimum CVI and Kappa Coefficient to be valid. In the global assessment of Amigos de Fibro, the CVI of the target audience judges was 0.95, while the expert judges presented a value of 0.90. The Kappa Coefficient of the target audience judges was 0.85 and that of the expert judges was 0.90. Therefore, the instrument proved to be validated. Conclusion Amigos de Fibro was considered valid for its content and internal consistency, therefore, valid to be used by health professionals with the target audience in Primary Health Care in Brazil, allowing them to act as promoters of their health. References [1]Antunes MD, Couto LA, Bertolini SMMG, Rocha Loures FCN, Schmitt ACB, Marques AP. of interdisciplinary health education programs for individuals with fibromyalgia: A systematic review. Journal of Education and Health Promotion. 2021;10(64):1-8. Doi: https://dx.doi.org/10.4103%2Fjehp.jehp_592_20 [2]Antunes M, Schmitt A, Marques AP. Ab0912-hpr Amigos de Fibro (Fibro Friends): educational program to promote the health of people with fibromyalgia in Brazil. 2021; Annals of the Rheumatic Diseases 2021;80:1478. [3]García-Ríos MC, Navarro-Ledesma S, Tapia-Haro RM, Toledano-Moreno S, Casas-Barragán A, Correa-Rodríguez M, et al. Effectiveness of health education in patients with fibromyalgia: a systematic review. European Journal of Physical and Rehabilitation Medicine. 2019;55(2):301–13, 2019. Doi: https://doi.org/10.23736/S1973-9087.19.05524-2 Acknowledgements This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001 Disclosure of Interests None declared
POS1568-PARE THE BRIEF-ILLNESS PERCEPTION QUESTIONNAIRE: A METHOD FOR ASSESSING THE COGNITIVE REPRESENTATION OF RHEUMATIC DISEASE
Authors: Z. Zeineb, S. Jemmali, S. Rekik, S. Boussaid, S. Rahmouni, K. Zouaoui, H. Sahli, M. Elleuch
Journal: Annals of the Rheumatic Diseases (2022)

Background The common-sense model proposes that illness perception (IP), is how patients make sense of their illness and respond emotionally to it, influencing the way they cope with the illness and subsequently illness outcomes. This proposition has gained considerable empirical support, and the relevance of IP in understanding illness-related behaviors or outcomes has also been supported in patients with rheumatic diseases (RD). The Brief Illness Perception Questionnaire (B-IPQ) was designed to provide a simple and rapid assessment of IP. This questionnaire has been widely used in diverse ages, illness types, countries, and languages. Objectives This study aimed to examine the construct of IP as measured by the B-IPQ in patients with RD. Methods A cross-sectional study was conducted at a Tunisian rheumatology department on 80 patients with RD. Sociodemographic, disease-related variables were reported. Participants completed a questionnaire on illness beliefs (B-IPQ). Results Subjects were aged 22-74 years (mean 51 years), 61.6 % were female. Diagnoses included Rheumatoid arthritis (RA) (63%), axial spondylarthritis (AS) (37%). The mean disease duration was 11 years and 7 years for RA and AS respectively. The proportion of physical comorbidities was higher in RA patients (36%) versus AS patients (11%). Disease activity was low in 28.8% of patients. All patients were on medications for their rheumatic disease, and 34,6 % were on biological therapy. In both diseases, the participants perceived their rheumatic illness as a chronic condition (9.4) that could be controlled by treatment (6.6) but not strongly influenced by personal actions (4.3). Overall, Rheumatic disease was seen as having an important impact on their life (7.9) without significant difference between patients with low or high activity disease (p=0.23). The majority believe that they have a moderate understanding of their illness (6.6). The frequency of symptoms was highly evaluated in RA patients than AS patients (7.3 vs 5.6) (p=0.01). In RA patients, 76% were extremely affected emotionally by their disease, however, the majority of AS patients were moderately affected emotionally with a significant difference (p=0.02). In addition, RA patients considered their disease mainly a result of psychological factors (66.8%). On the other hand, AS patients (73%) attributed their illness to various risk factors (especially physical overexertion). Conclusion High scores of B-IPQ shown in our studies, encourage the design of psychotherapeutic trials targeting disease-related cognitions in AS and RA in an attempt to improve patients’ reported outcomes and disease outcomes. Disclosure of Interests None declared
POS0487 THE CROSSTALK OF THE SKIN-ORAL-GUT MICROBIOME AXIS IN LIMITED AND DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS
Authors: E. Russo, D. Carboni, S. Baldi, B. Fioretto, E. Romano, K. El Aoufy, M. Ramazzotti, I. Rosa, G. Lepri, L. DI Gloria, C. Bruni, D. Melchiorre, S. Guiducci, M. Manetti, M. Matucci-Cerinic, A. Amedei, S. Bellando Randone
Journal: Annals of the Rheumatic Diseases (2022)

Background Systemic sclerosis (SSc) is a complex and still unclear rare disease. Microbiota has recently emerged as an important environmental factor in SSc pathogenesis, either at gut, oral and skin level. Objectives To investigate the role of microbiota in SSc subsets, focusing on the skin-oral-gut microbiota axis and serum and fecal free fatty acids (FFA) profile. Methods Twenty-six consecutive SSc patients (22 females) (mean disease duration (SD): 13 ± 6.91 yrs), classified according to the ACR/EULAR2013 criteria, were enrolled. Demographic, clinical and laboratory data were recorded. Gastrointestinal symptoms were investigated with UCLA GIT-2.0-questionnaire. Fecal, unstimulated saliva and superficial epidermal samples were collected. Microbiota was assessed through 16S ribosomal RNA Next Generation gene-sequencing analysis. Gas Cromatography-Mass Spettroscopy was used to measure FFAs in serum and fecal samples. Results Thirteen patients had limited cutaneous SSc (lcSSc), 13 diffuse cutaneous (dcSSc). The two subsets displayed a different cutaneous and fecal microbiota profile. In detail, the class of cutaneous Sphingobacteria was significantly higher in lcSSc (p&lt;0.05), while the phylum of Lentisphaerae , the family of Victivallaceae and the genus of Victivallis were significantly higher in fecal samples of lcSSc (all p&lt;0.05). A significant increase of fecal propionic acid was observed in lcSSc patients (p&lt;0.05). Moreover, all fecal medium-chain FAs and hexanoic acids were significantly higher in lcSSc (p&lt;0.05 and p&lt;0.001, respectively). The analysis of serum FFAs levels showed an increase of valeric and octanoic acids in lcSSc (both p&lt;0.05). A negative correlation between UCLA-GIT-2.0 total score and fecal octanoic acid (rho=-0.61; p=0.03), and a positive correlation with serum propionic acid (rho=0.55; p=0.05) was found in lcSSc. Conclusion Our findings show a different microbiota signature in the skin and gut, and a different FFAs profile in lcSSc and dcSSc. Such a differential regulation of microbiota composition and bacterial metabolite production suggests different dynamics of skin-oral-gut microbiota axis in SSc subsets. This data could be useful to develop personalized therapies targeting gastrointestinal and skin involvement. Disclosure of Interests None declared.
AB0155 VASCULAR ENDOTHELIAL GROWTH FACTOR IN JUVENILE IDIOPATHIC ARTHRITIS
Authors: O. Pavlova, N. Shevchenko, T. Holovko
Journal: Annals of the Rheumatic Diseases (2022)

Background Vascular changes are preceding the development of fibrosis in juvenile idiopathic arthritis (JIA). Signs of angiogenesis, the process of new vessel formation, cannot be fully detected, especially in childhood. Vascular endothelial growth factor (VEGF) is considered to play a crucial role for angiogenesis regulation [1,2]. Objectives To evaluate serum levels of vascular endothelial growth factor in the treatment of juvenile idiopathic arthritis. Methods 104 consecutive JIA patients aged 10 to 18 years (13.3 ± 0.3) were included in this 4-years prospective study. VEGF levels were determined by VEGF ELISA kits. Serum levels of VEGF were analyzed depending on patients’ gender, age, and age of JIA onset, its variant, duration, activity, and presence of methotrexate (MTX) in treatment and its dose. Results We evaluated VEGF level for children with JIA (min: 23.68 pg/ml; Me:244.75 pg/ml; max: 2158.91 pg/ml). VEGF in JIA was related to onset of JIA in patients older than 15 years and high disease activity according JADAS-27 pattern (p˂0.05). Levels of circulating immune complex (CIC) and antistreptolysin-o (ASL-O) was associated with VEGF level. Mostly VEGF was correlated with CIC (among: girls r=0.53, patients with oligoarthritis r=0.55, inactive disease activity according to JADAS-27 r=0.47, dose of МТХ, 10–12,5mg/m2/week r=0.67 p ˂ 0.05) and with ASL-O (among: girls r=0.47, inactive disease activity according to JADAS-27 r=0.51, MTX treatment r= 0.36, dose of МТХ, 10–12,5mg/m2/week r=0.90 p ˂ 0.05). Conclusion Children with JIA had a higher VEGF level in patients older than 15 years and high disease activity. Also, CIC and ASL-O showed high impact on VEGF level which is the critical factor of angiogenesis. References [1]Wu, C. Y., Yang, H. Y., Huang, J. L., &amp; Lai, J. H. (2021). Signals and Mechanisms Regulating Monocyte and Macrophage Activation in the Pathogenesis of Juvenile Idiopathic Arthritis. International journal of molecular sciences, 22(15), 7960. https://doi.org/10.3390/ijms22157960 [2]Świdrowska-Jaros, J., &amp; Smolewska, E. (2018). A fresh look at angiogenesis in juvenile idiopathic arthritis. Central-European journal of immunology, 43(3), 325–330. https://doi.org/10.5114/ceji.2018.80052 Disclosure of Interests None declared