tbuckley/cabot-search huggingface dataset:
A 61-Year-Old Man With Parkinson's Disease, 1 Year Later
Authors: Thomas L. Delbanco
Journal: JAMA (1996)

At the Neurology Grand Rounds held approximately 1 year ago, C. Warren Olanow, MD, discussed the evaluation and management of a 61-year-old man with Parkinson's disease (PD).<sup>1</sup>Dr Olanow stressed the proper diagnosis of PD, provided information on its etiology and pathogenesis, and explained current treatment options, including neuroprotective and restorative therapies. The audience and Dr Olanow also discussed the care of PD-associated depression and how the primary care physician should handle PD in a managed care setting. We asked the patient and his primary care doctor to comment on the year that has passed. <h3>Dr H, THE PATIENT:</h3> In February, I suffered a coronary and required cardiac catheterization and angioplasty. Fortunately, I'm recovering nicely from my myocardial infarction, but do feel there are some noticeable changes in me physically, mentally, and emotionally. My wife shares these same feelings and concerns. Within these past 8 months, my mental alertness
The Antiscurvy Vitamin in Apples.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bipolar affective disorder
Authors: T. J P Verberne
Journal: BMJ (2002)

In vivo bromodeoxyuridine (BrdUrd) labelling of the human large bowel was performed and a detailed histochemical localisation of label in sections of crypts was undertaken using a monoclonal antibody to BrdUrd containing DNA. Flow cytometric studies on extracted nuclei were also performed (data presented elsewhere). The average crypt in the human large bowel (excluding the rectum) was 82 cells in height and 41 cells in circumference, with a total of about 2000 cells (assuming a topographical correction factor of 0.6). Ten per cent of the cells were replicating their DNA--that is, were in the S phase of the cell cycle--and 0.4% were in mitosis. The median position for the labelling index versus cell position frequency plot is at the 20th cell position--at a quarter of the crypt height. The lower and upper limits of the cell proliferation are given by the 5th and 95th percentiles at cell positions 4 and 43 respectively. The peak labelling index is about 30% and it occurs at cell position 15. The labelling index at the crypt base, the probable stem cell zone, is about 14%, suggesting that these cells have a longer cell cycle. Taking a value of 8.6 hours for the duration of the S phase (deduced from the flow cytometric data) and assuming a growth fraction of 1.0 for the mid-crypt, these data provide an estimate of about 30 hours for the cell cycle time. The rectal crypts are about the same size but contain about 30% fewer S phase cells. The data also yielded a per cent BrdUrd labelled mitosis curve.
Reproductive Capacity and Viability at Higher Temperatures of Various Transformed Hamster Cell Lines&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Z. F. CH. Kachani, Albert B. Sabin
Journal: JNCI Journal of the National Cancer Institute (1969)

Hamster cells transformed to malignancy in vitro by the polyoma virus or simian virus 40 (SV40) possess a reproductive capacity (rct) at 41.6°C (rct/41.6°C+) that is not exhibited by cells transformed in vitro by X irradiation, dimethylnitrosamine, untreated hamster-embryo cultures, or by cell cultures derived from tumors initially produced in vivo by the polyoma virus and SV40. Temperatures (t) that inhibited multiplication did not kill the cells. However, cell cultures derived from serially transplanted SV40 and polyoma virus tumors produced in vivo exhibited a distinctly lower viability ranging from 41.3-41.6°C (t/41.3-41.6°C) than those derived from a serially transplanted, sodium cholate tumor produced in vivo, or cultures transformed in vitro by these viruses, ×p irradiation, dimethylnitrosamine, or untreated hamster-embryo cultures. Uncloned or cloned rct/41.6°C+, t/41.6°C+ cultures of cells transformed in vitro by SV40 or polyoma virus, transplanted one or more times in weanling hamsters, produced tumors that yielded rct/41,6°C−, t/41.6°C+ cultures, indicating that reproductive capacity and viability at certain higher temperatures are determined by different factors or genes. Two hamster cell lines, transformed in vitro by human or simian adenoviruses, were rct/41.6°C” and t/41°C+.
Highlights of This Issue
Journal: Clinical Cancer Research (2010)

Although decreased serum selenium levels have been associated with a number of malignancies, further work is needed to clinically demonstrate the benefits of selenium supplementation, as well as to define the mediators of these potential benefits.Here, Silvers and colleagues demonstrate that selenium-binding protein 1 (SELENBP1) expression is decreased in patients with esophageal adenocarcinoma, and that its expression is modulated by both epigenetic and posttranscriptional mechanisms.Further, ectopic overexpression of SELENBP1 in esophageal adenocarcinoma cell lines resulted in enhanced apoptosis, increased senescence, and greater sensitivity to cisplatin.These findings may impact strategies for the chemoprevention and/or treatment of esophageal cancer.
Allergy in Relation to Pediatrics
Journal: JAMA (1952)

covers in excellent fashion the differential diagnosis of the acute abdomen.It affords the physician the background of information essential to evaluate an acute abdomen and to attain therapeutic judgment.It is small, compact, can be read with advantage in a few hours, and will serve as a handy reference book for student, general practitioner, and specialist alike.It is recommended for perusal or study by any physician encountering acute abdominal conditions in practice.It is a valuable contribution to medical literature and deseirves to be in the library of practicing physicians.
Lang's German-English Dictionary of Terms Used in Medicine and the Allied Sciences.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Waterhouse-Friderichsen Syndrome Induced by Pneumococcemic Shock
Authors: Morton D. Grant
Journal: JAMA (1970)

A 54-year-old woman with a brief febrile illness presented with shock and ecchymoses. Coagulation studies demonstrated thrombocytopenia, hypofibrinogenemia, prolonged thrombin and prothrombin times, and circulating fibrin split products. The autopsy disclosed a pneumococcal bacteremia (with early changes suggesting pneumonia), bilateral hemorrhagic necrosis of the adrenals (the Waterhouse-Friderichsen syndrome) and a small previously infarcted spleen. A review of six previous reports of the Waterhouse-Friderichsen syndrome complicating pneumococcal bacteremia revealed splenic abnormalities in four. Splenic pathology and shock are suggested as important concomittants of this very rare complication of pneumococcal infection.
ANKYLOSIS.ARTHROPLASTY—CLINICAL AND EXPERIMENTAL.
Authors: JOHN B. MURPHY
Journal: JAMA (1905)

The subject of ankylosis and its treatment presents many problems for consideration. In order immediately to emphasize the salient points of the subject, we will ask some questions: What are joints? What is the embryology of joint formation? What is the pathologic histology of acquired arthroses or false joints? What is the pathology of hygromata (acquired endothelial lined sacs)? Can they be produced artifically? What is ankylosis? What are the pathologic and anatomic changes included in the term? What tissues are involved? From a practical standpoint, into what classes may it be divided? When ankylosis has formed, what are the limitations of surgery for its relief? Can we re-establish a movable, functionating joint with synovial lining? Can we restore motion and to what degree? In what class of cases can the best results be secured? Can we for the future promise better than the flexible, fibrous unions that we have secured in the past?
Effects of Mitomycin on Human Colon Carcinoma Cells&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1984)

Subpopulations of malignant cells from primary cultures of human colon carcinoma were characterized with respect to their response to mitomycin (MMC). Growth inhibition assays indicated values of 2.06, 0.93, and 0.33 µM for the concentration of drug giving 50% inhibition of growth for sublines HCT 116b, HCT 116, and HCT 116a, respectively. Alkaline elution of filter-bound DNA from cells exposed to MMC in vitro showed a positive correlation between the amount of DNA cross-linking and growth inhibition as a function of drug concentration. Comparable DNA cross-linking was obtained at MMC concentrations of 10 µM for HCT 116b and 5 µM and HCT 116. The cross-linking of DNA from HCT 116a cells at 5 µM MMC was approximately equal to that from HCT 116 cells at doses between 10 and 20 µM MMC. Cross-link removal as a function of time after drug removal of MMC-treated cells was also measured. There was little difference in the rates of alkaline DNA elution after drug removal between HCT 116b and HCT 116a, suggesting that the ability to repair cross-links was not responsible for the differential sensitivities of the cells to MMC. The relative sensitivities of the subpopulations to MMC were reflected in vivo by MMC treatment of nude BALB/c mice bearing xenografts of the cultured sub-lines
Psychiatric Aftercare in a General Hospital A System of Prevention in the Community
Authors: S.L. Safirstein
Journal: Psychotherapy and Psychosomatics (1968)

Research Articles| February 12 2010 Psychiatric Aftercare in a General Hospital A System of Prevention in the Community Subject Area: Psychiatry and Psychology S.L. Safirstein S.L. Safirstein Department of Psychiatry, Institute of Psychiatry, The Mount Sinai Hospital, New York, N. Y. (Director: M. Ralph Kaufman, M. D.) Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1968) 16 (1-3): 16–22. https://doi.org/10.1159/000285913 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation S.L. Safirstein; Psychiatric Aftercare in a General Hospital A System of Prevention in the Community. Psychother Psychosom 31 December 1968; 16 (1-3): 16–22. https://doi.org/10.1159/000285913 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1968Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Maternal Birth Weight and Subsequent Pregnancy Outcome
Authors: Evette Hackman
Journal: JAMA (1983)

The relationship between maternal birth weight and future reproductive outcome was studied in a cohort of 748 white women with singleton pregnancies. Maternal birth weight was significantly related to stature, prepregnancy weight, pregnancy weight gain, baby's birth weight, gestational duration, relative intrauterine growth, the baby's need for neonatal intensive care, transient tachypnea of the newborn, and idiopathic respiratory distress syndrome. Mothers who weighed 2,000 g or less at birth were at elevated risk for poor pregnancy outcome, although their babies were not smaller than babies of most groups of mothers who weighed more at birth. This suggests that factors interfering with intrauterine growth have an impact on the next generation of babies. In view of the increasing survival of low-birth-weight babies, this possibility bears further investigation. (<i>JAMA</i>1983;250:2016-2019)
Agnosia, Apraxia, Aphasia. Their Value in Cerebral Localization.
Journal: Annals of Internal Medicine (1947)

the reader in the approach to the interpretation of the unknown electrocardiogram.This purpose is satisfactorily fulfilled, and an excellent sampling of the vari- eties of electrocardiograms encountered in clinical prac- tice is presented.Interpretative data and clinical corre- lations are concisely and conveniently presented.The inclusion of more cases in which necropsy material could be correlated with clinical conclusions would be desirable.
An Introduction to Chemical Analysis, for Students of Medicine, Pharmacy and Dentistry.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transplantable Hepatomas Induced in Strain-2 Guinea Pigs by Diethylnitrosamine: Characterization by Histology, Growth, and Chromosomes
Journal: JNCI Journal of the National Cancer Institute (1969)

Six hepatomas, each induced in a different strain-2 guinea pig, were studied. Four of the six tumors were different in histologic appearance, transplantability, and chromosomal constitution. Two of the six tumors (lines 1 and 8) were similar in these characteristics. During transplantation of one of the tumors (line 7 in the ascites form), a subline arose that differed from line 7 in histologic appearance, transplantability, and chromosomal constitution. This subline (7B) was biologically similar to lines 1 and 8.
Highlights from Recent Cancer Literature
Journal: Cancer Research (2013)

EMT and the Warburg Effect in Breast CancerThe Warburg effect (aerobic glycolysis) in cancer arises from the observation that tumor cells preferentially metabolize glucose to lactate through glycolysis, bypassing oxidative phosphorylation, even in the presence of oxygen.Although oncogene activation (e.g., Myc) can activate the Warburg effect via regulation of the catabolic pathway of glucose, the contribution of gluconeogenesis enzymes to this process is less clear.Fructose-1,6-bisphosphatase (FBP1) is a rate-limiting enzyme in gluconeogenesis.Dong and colleagues examined a role for FBP1 in the Warburg effect by studying the basal-like subtype of breast cancer, known to exhibit epithelial-mesenchymal transition (EMT), in part through activation of the Snail transcription factor.They first linked FBP1 and basal-like breast cancer by showing that FBP1 expression is inversely associated with Snail expression.FBP1 expression suppressed Snail-induced EMT and the basal-like phenotype in breast cancer cells.Snail overexpression in cell lines suppressed expression of FBP1, and chromatin immunoprecipitation revealed that the transcriptional repressor Snail was associated at the FBP1 promoter.Further work showed that Snail-mediated EMT resulted in changes in epigenetic marks at the FBP1 promoter, including increased G9a and H3K9me2 and decreased H3K9ac.Subsequently, FBP1 was shown to inhibit glucose uptake and activate oxidative phosphorylation.Mechanistically, the authors demonstrated that FBP1 suppressed pyruvate kinase (PKM2), a known activator of lactate production and the Warburg effect.Because FBP1 enhances oxygen consumption, they reasoned that it might stimulate activity of the mitochondrial electron transport system.Gene expression profiling showed that FBP1 overexpression resulted in upregulation of mitochondrial transcription factor B1M (TFB1M), a gene that is essential for mitochondrial biogenesis.Components of mitochondrial complex 1 were also upregulated as a result of FBP1 expression.This evidence suggests a direct role for FBP1 in tumorigenesis, as FBP1 overexpression inhibited tumor sphere formation, whereas FBP1 knockdown enhanced tumor sphere formation in breast cancer cells.This study implicates FBP1 as a potentially important link between Snail-mediated EMT and the Warburg effect in basal-like breast cancer.
Human Monoclonal Antibody Against Ganglioside G&lt;sub&gt;D2&lt;/sub&gt;: Use in Development of Enzyme-Linked Immunosorbent Assay for the Monitoring of Anti-G&lt;sub&gt;D2&lt;/sub&gt; in Cancer Patients&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Tadashi Tai, Leslie D. Cahan, James C. Paulson, Romaine E. Saxton, Reiko F. Irie
Journal: JNCI Journal of the National Cancer Institute (1984)

Ganglioside GD2 is expressed on membranes of human melanoma cells and induces antibody responses in patients with melanoma. In this study a new enzyme-linked immunosorbent assay was developed for detection of human antibody against GD2. A human IgM monoclonal anti-GD2 antibody was used for development of the assay. The antigen, GD2, was prepared from human brain. Four micrograms of GD2 was required to coat a well in a polystyrene microtiter plate. As little as 10 ng of antibody could be detected. The applicability of the assay for detection of serum anti-GD2 antibody was demonstrated with sera from patients immunized with GD2-positive melanoma cell vaccine.
Cystoscopic Control of Hemorrhage via Gastrostomy
Authors: C. Roger Youmans
Journal: JAMA (1970)

<h3>To the Editor.—</h3> In suitable cases gastric bleeding points may be effectively effulgurated, with satisfactory control of severe hemorrhage. <h3>Report of a Case.—</h3> A 63-year-old man was admitted on Feb 20,1966, with a history of increasing dysphagia and weight loss. Barium swallow, esophagoscopy, and scalene node biopsy confirmed the diagnosis of inoperable squamous cell carcinoma in the mid portion of the esophagus. Roentgenographic therapy was started after producing a feeding gastrostomy. Following administration of 4,035 rads in 31 days, the patient suddenly experienced massive gastrointestinal hemorrhage and the hemoglobin level fell to 4.1 gm/100 ml. Studies confirmed hemorrhage from the stomach, and a large ulceration of the lesser curvature. In spite of the usual procedures for control of gastric hemorrhage, persistent bleeding required transfusion of 8 units of blood over a 24-hour period. Examination of the stomach with a cystoscope passed through the gastrostomy, revealed a large ulcer of the