tbuckley/cabot-search huggingface dataset:
AB1022 PLACE OF BONE MINERAL DENSITY MEASUREMENT IN THE DIAGNOSIS OF ASYMPTOMATIC VERTEBRAL FRACTURES
Authors: M. Brahem, O. Jomaa, R. Sarraj, S. Abdellatif, R. Ben Tekaya, H. Hachfi, Y. Mohamed
Journal: Annals of the Rheumatic Diseases (2022)

Background Vertebral fracture (VF) is the most common fragility fracture. The majority of them are asymptomatic and only third of VFs are clinically recognized. Screening of osteoporosis may increase early detection of these fractures. Objectives to emphasize on the routine practice the lateral and frontal X-rays of dorso-lumbar spine each time that the diagnosis of osteoporosis has been made. Methods This is a cross-sectional study which includes patients followed for a well-defined rheumatological disease in the rheumatology department at TAHER SFAR University Hospital, Mahdia, Tunisia. All patients had a bone mineral density (BMD) measurement whenever there is an indication according to the HAS 2006 recommendation with a systematic radiography of the dorso-lumbar spine (face and profile incidences). Results Thirty seven female patients were enrolled, with a mean age of 59.8 ± 9.9 years. The average body mass index was 30.85 ± 5.7kg/m2 and 83.7% of them were overweight (BMI&gt;25kg/m2). 86.5% of patients had a history of back pain and 16.2% of them had a family history of fracture of the femoral upper extremity. The reasons for performing BMD were dominated by corticosteroid therapy ≥7.5mg/d for more than 3 months and a history of vertebral fracture in 37.8% of cases each and treatment with anti-aromatases in 16.2% of cases .18 patients had a Spinal T-score ≥-2.5 DS. 12 patients had a spinal Tscore between -2.5 DS and -1 DS. 6 patients had a femoral Tscore ≥-2.5 DS and 12 had a femoral Tscore between -2.5 DS and -1DS. 19/37 patients (51.4% of cases) had osteoporosis. 9/19 (47.3%) had a vertebral fracture among which 12% were previously unknown and in women who were fully symptom-free. The vertebral fractures were mainly located at the dorsal-lumbar region: the L1 and T11 vertebrae were fractured in 3 patients and the T12 vertebrae in 3 patients. Conclusion Our study showed that nearly half of patients with BMD-objectified osteoporosis had a VF detected on standard X-rays, most of which were previously unknown. It is plausible to speculate the place of this method combining BMD with spinal X-rays in the diagnosis of asymptomatic VFs. References [1]doi: 10.18773/austprescr.2016.020 Disclosure of Interests None declared
AB1565-HPR REHABILITATION NURSES KNOWLEDGE ABOUT OSTEOPOROSIS AND FRAGILITY FRACTURES IN PORTUGAL
Authors: G. Pimentel, A. Cruz, M. Loureiro, S. Fernandes, C. Baixinho, A. Marques
Journal: Annals of the Rheumatic Diseases (2022)

Background Scientific evidence reveals gaps in health professionals’ knowledge about osteoporosis and fragility fractures, which impairs and influences the quality of care, namely in preventive actions. Objectives To analyse knowledge of Rehabilitation Nurses about osteoporosis and fragility fractures to identify training needs of Rehabilitation Nurses. Methods A cross-sectional study, integrated in a larger project, using an adapted questionnaire, made available online and disseminated by mailing list of “Ordem dos Enfermeiros” (Royal Colleague of Nursings) to all Portuguese Rehabilitation Nurses. Results There were include 452 participants(10.3% of the 4 397 Rehabilitation Nurses), 17% perform functions in orthopaedics and traumatology service, 4.5% physical medicine and rehabilitation and 78.6% in other services, majority, 74.6% women. On average, 69.6% correct answers were identified regarding osteoporosis and fragility fractures. Results reveal that the main areas of knowledge deficit, in this study, are related to the concept and epidemiology of osteoporosis and fragility fractures and about the most appropriate diet. Nurses with higher academic degree (master’s degree) revealed more knowledge (p=0.01). Conclusion This study reveals that the knowledge about osteoporosis and fragility fractures is low (&lt;70% correct answers), thus there is an opportunity to improve the knowledge related to osteoporosis and fragility fractures among Specialist Nurses in Rehabilitation Nursing. References [1]Peng, L., Reynolds, N., He, A., Liu, M., Yang, J., She, P., &amp; Zhang, Y. (2020). Osteoporosis knowledge and related factors among orthopedic nurses in Hunan province of China. International journal of orthopaedic and trauma nursing , 36 , 100714. https://doi.org/10.1016/j.ijotn.2019.100714 Disclosure of Interests None declared
AB1055 GENDER DIFFERENCES IN TAKING XANTHIOXIDASE INHIBITORS IN GOUT
Authors: M. Gromova, V. Tsurko
Journal: Annals of the Rheumatic Diseases (2022)

Background There is little evidence of a possible difference between men and women in response to urate-lowering therapy (ULT). Objectives To compare the clinical characteristics of the gout course and evaluate the differences in response to ULT with allopurinol and febuxostat in men and women. Methods The retrospective cohort study included 279 men and 83 women diagnosed with gout (ACR/EULAR, 2015). The comparative analysis of the clinical characteristics of gout and responses to taking xanthioxidase (XO) inhibitors in representatives of different genders was conducted. We compared the gender characteristics of obtaining a positive response to ULT, defined as achieving a target serum uric acid (sUA) level of &lt;360 μmol/l within 6 months of treatment with allopurinol and febuxostat. Results By the age when gout manifistated women were older than men, the duration of their disease was shorter. Men showed a shorter duration of the first arthritis attack. Chronic arthritis was diagnosed in 56% of men and 35% of women (p &lt;0,05). The process involved the joints of the lower and upper extremities. More often the joints of the lower extremities were affected in men, and in the upper extremities in women. Tophus were detected in 35% of patients: 30,3% – men, 4,7% – women (p &lt;0,05). Allopurinol was prescribed to 216 men and 54 women, febuxostat – to 63 men and 29 women. After six months the proportion of women who achieved the target sUA was 57,5% and 65,8%, the proportion of men – 60,4% and 76,2% for allopurinol and febuxostat, respectively. Conclusion The clinical manifestations of gout in men and women differ. Due to the marked increase in the uric acid level, men develop more severe joint damage because of the tendency to chronicity. However, the study did not reveal gender differences in the response to XO inhibitors, which indicates that there is no need to choose therapy depending on the patient’s gender. Disclosure of Interests None declared
Retraction Note to: Activation of LncRNA TINCR by H3K27 acetylation promotes Trastuzumab resistance and epithelial-mesenchymal transition by targeting MicroRNA-125b in breast Cancer
Authors: Huaying Dong, Jianguo Hu, Kejian Zou, Mulin Ye, Yuanwen Chen, Chengyi Wu, Xin Chen, Mingli Han
Journal: Molecular Cancer (2022)

This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-018-0931-9.
AB0378 EFFECT OF RITUXIMAB ON BONE MINERAL DENSITY IN WOMEN WITH RHEUMATOID ARTHRITIS
Authors: O. Dobrovolskaya, N. Demin, N. Toroptsova, A. Sorokina, D. Kusevich, O. Nikitinskaya
Journal: Annals of the Rheumatic Diseases (2022)

Objectives To compare the effect of rituximab (RIT) treatment on bone mineral density (BMD) in women with rheumatoid arthritis (RA) and those with RA without biological therapy. Methods 78 women over 40 years with confirmed RA according to ACR/EULAR criteria (2010) were enrolled in the study: 48 patients treated with RIT and methotrexate (RIT+) and 30 women received only methotrexate (RIT-). The patients did not differ in the glucocorticoid therapy duration and cumulative dose. BMD was determined in the lumbar spine, femur neck and total hip using dual energy x-ray absorptiometry (DXA, Hologic 4500A) at baseline and after 1 year. RA activity was evaluated by disease activity score using 28 joint counts and erythrocyte sedimentation rate (DAS28 ESR). Nonparametric statistic tests were performed. Results There were no differences between patients RIT+ and RIT- in age (median - 58 [53; 63] years and 52 [50; 69] years, p&gt;0.05), RA duration (median – 15 [4; 21] year and 9 [3; 11] year, p&gt;0.05) and DAS28 ESR (median – 5.18 [4.35; 6.25] and 5.71 [4.66; 5.94]). The percentage BMD changes from baseline in lumbar spine, femoral neck and total hip were 0.2% [-3.9%; 4.0%], -1.8% [-6.2%; 2.4%] and -0.3% [-3.5%; 4.5%], respectively, in patients RIT+ and -1.0% [-4.9%; 3.3%], -2.5% [-5.8%; -0.4%], -1.7% [-4.3%; 4.2%], respectively, in persons RIT-. There were no differences in BMD changes in the pair matching test both patients RIT+ and RIT-. No correlations between BMD changes with age, RA duration and DAS28 ESR were found. Conclusion RIT had no effect on BMD in women with RA after 1 year therapy. BMD changes were not associated with age, RA duration and disease activity. Disclosure of Interests None declared
AB1215 A COMPARATIVE ANALYSIS OF RADIOLOGICAL FINDING BETWEEN TUBERCULOUS, BRUCELLAR AND PYOGENIC SPONDYLODISCITIS
Authors: N. Ben Chekaya, F. Fhima, S. Zrour, I. Bejia, M. Touzi, M. Jguirim, N. Bergaoui
Journal: Annals of the Rheumatic Diseases (2022)

Background Infection spondylodiscitis (IS) is a serious infectious disease which involves intervertebral disc and its adjacent vertebral bodies but later may also extend into the the adjacent neural structures. The clinical picture of IS is rather non specific but there are significant radiological differences that permit a presumptive aetiological diagnosis and orient the initial empirical treatment. Objectives This study aimed to compare the radiological features of of tuberculous (TS), brucellar (BS) and pyogenic spondylodiscitis (PS). Methods A retrospective monocentric study involving 70 cases of infectious spondylodiscitis admitted between January 2009 and August 2019 at our rheumatology department. Clinical, laboratory and radiological data of the patients were collected. Results Of these 70 patients, 18 (25.7%) had TS, 8 (11.4%) BS and 44(62.9%) PS. There were 37 women (52.9%) and 33 men (47.1%). The age of the patients ranged from 12 to 82 years, with a mean of (SD±) 54± 15,23 years. Standard X-rays showed abnormalities suggestive of spondylodiscitis in 78.6% of cases. A great majority of the patients had involvement at only one vertebrae level (70%). The most frequently affected level, were the thoracic (33.3%), the lombosacral (100%) and the lombar (38.6%) segment in the TS, BS and PS respectively. In BS the lombosacral segment was significantly the most frequently affected level (p&lt;0.0037). Computed tomography was performed in 52.9% of cases and showed that the epidural and paravertebral abscess were characteristic of tuberculous involvement (p=0.013 and 0.05). Magnetic resonnance imaging was performed in 63% of cases. The intervertebral disc narrowing was observed in 87.3% of patients. Paravertebral or epidural masses were present respectively in 53.5% and 86.7% of TS, versus 14.3% and 71.4% of BS, and 46.3% and 80.5% of PS, there were no significant differences between the groups.The enhancement was rather heterogeneous in the SDT and homogeneous in the two other groups, but these differences were not statistically significant. Conclusion There are significant radiological differences between TS, BS and PS. A better understanding of typical and atypical manifestations on imaging can be an excellent diagnostic tool for every attending physician. Disclosure of Interests None declared
AB0130 DEREGULATION OF TFAM EXPRESSION PROMOTES MITOCHONDRIAL DAMAGE AND FIBROBLAST ACTIVATION IN SYSTEMIC SCLEROSIS
Authors: X. Zhou, T. Trinh-Minh, C. Tran Manh, A. Giessl, C. Bergmann, A. H. Györfi, G. Schett, J. H. W. Distler
Journal: Annals of the Rheumatic Diseases (2022)

Background Transcription factor A, mitochondrial (TFAM) is a transcription factor with essential function in the mitochondrial homeostasis, such as mitochondria biogenesis and mtDNA replication. Deregulation of TFAM expression has been linked to mitochondrial dysfunction. However, its role in the pathogenesis of rheumatic diseases has not been studied so far. Objectives We aimed to study the role of TFAM in the pathological fibroblast activation in SSc. Methods The expression of TFAM in SSc skin fibroblast and skin biopsies was analyzed by immunofluorescence and Western blot. The role of TFAM in fibroblast activation was investigated by TFAM knockdown in cultured fibroblasts. The role of TFAM in skin and lung fibrosis was further studied in mice with fibroblast specific knockout of TFAM in three independent mouse models: Bleomycin-induced skin and lung fibrosis as well as TβRI act -induced skin fibrosis. Results Dermal fibroblasts from SSc patients express lower level of TFAM in the skin and also after prolonged culture in vitro. The downregulation of TFAM impairs mitochondria homeostasis with decreased mitochondrial number, accumulation of damaged mitochondria with release of mtDNA, accumulation of deletions in mtDNA, metabolic reshaping with impaired OXPHOS and release of the mitokine GDF15. Long time, but not acute exposure of normal fibroblasts to TGFβ mimicked the finding in SSc fibroblasts with downregulation of TFAM and mitochondrial homeostasis disruption and damage. Knockdown TFAM of normal fibroblasts promotes fibroblast activation with increased myofibroblast differentiation and collagen release in a SMAD3 dependent manner. RNA sequencing demonstrated upregulation of pro-fibrotic genes and pathways. Mice with fibroblast-specific knockout of TFAM demonstrate are more sensitive to fibrotic stimuli such as bleomycin injection and TβRIact-overexpression and even demonstrate responses to NaCl instillation. Conclusion Alterations in the key mitochondrial transcription factor TFAM in response to prolonged activation of TGFβ and associated mitochondrial damage induce transcriptional programs that promote fibroblast activation and tissue fibrosis. Disclosure of Interests Xiang Zhou: None declared, Thuong Trinh-Minh: None declared, Cuong Tran Manh: None declared, Andreas Giessl: None declared, Christina Bergmann: None declared, Andrea-Hermina Györfi: None declared, Georg Schett: None declared, Jörg H.W. Distler Consultant of: Actelion, Active Biotech, Anamar, Bayer Pharma, Boehringer Ingelheim, Celgene, Galapagos, GSK, Inventiva, JB Therapeutics, Medac, Pfizer, RuiYi and UCB.,, Grant/research support from: Anamar, Active Biotech, Array Biopharma, aTyr, BMS, Bayer Pharma, Boehringer Ingelheim, Celgene, Galapagos, GSK, Inventiva, Novartis, Sanofi-Aventis, RedX, UCB.
AB1196 INFLUENCE OF NEUROPATHIC PAIN ON THE FUNCTIONAL STATUS OF ELDERLY PATIENTS WITH RHEUMATOID ARTHRITIS
Authors: E. Sapozhnikova, M. Sapozhnikov, E. Guryanova, N. Alekseeva
Journal: Annals of the Rheumatic Diseases (2022)

Objectives The aim of the study was to study the influence of neuropathic pain on functional status in elderly patients with rheumatoid arthritis (RA) with moderate disease activity. Methods Methods. The study included 115 geriatric patients who were divided into two groups. Group G1 included 80 patients (mean age 76.9 ± 9.6 years) with neuropathic pain, group G2 - 35 persons of comparable age (77.1 ± 8.6 years) without signs of neuropathic pain. Neuropathic pain was identified using the DN4 questionnaire. The RA activity in patients of both groups did not differ statistically significantly. All patients underwent a comprehensive geriatric assessment (CGA) to determine the functional status and diagnose geriatric syndromes [1]. All patients received basic anti-inflammatory drugs. Patients G1 and G2 were compared in terms of the following parameters, such as pain intensity according to a visual analogue scale (VAS, 0-100 mm), Rivermead Mobility Index (0-15), functional disorders according to International Classification of Function (ICF) (0-4), signs of anxiety and depression (HADS). Results According to the CGA data, senile asthenia syndrome was detected in 32 (40.2%) patients with neuropathic pain and in 10 (28.6%) patients without neuropathic pain (p = 0.035). The average number of geriatric syndromes in G1 was 6.06 ± 1.03, in group B - 4.5 ± 1.0 (p &lt;0.05). Patients with G1 showed higher indices of pain severity according to VAS than in patients of the control group: 68.2 ± 10.1 and 52.1 ± 4.1 mm, respectively (p &lt;0.001). In G1, patients had a significant decrease in mobility, in the domain «Activity and participation» in the ICF categories d450 (walking), d 540 (dressing), the indicator of dysfunction was 2.9 ± 0.3 versus 2.2 ± 0.2 (p = 0.049), there were more symptoms of anxiety and depression 56.5% and 35.2% (HADS ≥7; p &lt;0.001), respectively. Conclusion Elderly patients with chronic neuropathic pain have higher signs of senile asthenia and decreased mobility and physical functioning in daily life. It is necessary to include the help of a psychologist and occupational therapist in planning the most effective comprehensive strategies for the treatment and prevention of exacerbations of neuropathic pain. References [1]Guryanova E.A., Rechapova E.A., Sidyakina E.S. Effectiveness of Comprehensive Geriatric Assessment in Improving the Quality of Life of Older People and Reducing the Workload of Their Caregivers // Acta medica Eurasica. – 2021. – № 4. – С. 79–90. – URL: http://acta-medica-eurasica.ru/single/2021/4/9 . DOI: 10.47026/2413- 4864-2021-4-79-90. Disclosure of Interests None declared
AB0363 COMPARING THE ULTRASONOGRAPHIC EVALUATION IN PATIENTS WITH JAPANESE RHEUMATOID ARTHRITIS BETWEEN JAK AND TNF INHIBITOR THERAPY
Authors: Y. Kanayama, A. Nagata, M. Shimotake, F. Miyachi, K. Fujita, M. Koyama, S. Uno
Journal: Annals of the Rheumatic Diseases (2022)

Background JAK inhibitor (JAK) and TNF inhibitor (TNF) are the important therapeutic agent for the treatment of rheumatoid arthritis.However there is still few studies of improvement of ultrasonographic findings in RA treated comparison with JAK and TNF. Objectives To evaluate the clinical efficacy of JAK and TNF therapy patients with rheumatoid arthritis (RA) using ultrasonography (US). Methods Participants comprised 32 and 39 Japanese RA patients who had recently received JAK (BAR23, PEF9) and TNF. All patients with a diagnosis of RA according to the 2010 ACR/EULAR criteria. Patients underwent clinical and laboratory assessments every 4 weeks from baseline to 24 weeks, and US assessments at baseline, 4, 12 and 24 weeks. Gray scale (GS) and power doppler (PD) signals were scored using a semi-quantitative scale from 0 to 3 at 26 (0-78) synovial sites (22 joints) in the following joints: bilateral first to fifth metacarpopharangeal (MCP) joints (dorsal recess); first interphalangeal (IP) and second to fifth proximal interphalangeal (PIP) (dorsal recess) joints; and the wrists (dorsal radial, median and ulnar). We evaluated the improvement of GS and PD score from baseline to week 24. Results In the patients receiving JAK (n=32) and TNF (n=39), the mean age was 54.7 vs 55.1 years old (p=0.871), disease duration was 7.4 vs 6.1 years (p=0.290), the rate of MTX use was 75% vs 87% (p=0.187), the mean MTX dose was 9.9 vs 10.2 mg/w (p=0.813), the rate of ACPA positive was 94% vs 79% (p=0.086), DAS28-ESR was 4.79 vs 4.65 (p=0.435), CDAI was 22.4 vs 19.1 (p=0.239), GS score was 20.8 vs 18.3 (p=0.995) and PD score was 14.0 vs 11.0 (p=0.940). The degree of improvement respective changes in GS and PD score after 4, 12 and 24 weeks were as follows: GS: -5.1 vs -4.3 (p=0.817) and PD: -5.3 vs -2.7 (p=0.855) after 4 weeks, GS: -9.1 vs -6.6 (p=0.880) and PD: -7.9 vs -4.5 (p=0.476) after 12 weeks, GS: -10.4 vs -9.5 (p=0.463) and PD: -8.1 vs -6.7 (p=0.968) after 24 weeks between JAK and TNF (Figures 1 and 2). Next, The improvement rate of respective changes in GS and PD score after 4, 12 and 24 weeks were as follows: GS: -13.7% vs -18.3% (p=0.489) and PD: -20.4% vs -16.5% (p=0.777) after 4 weeks, GS: -29.7% vs -26.0% (p=0.922) and PD: -30.9% vs -30.8% (p=0.890) after 12 weeks, GS: -38.1% vs -36.4% (p=0.567) and PD: -33.4% vs -50.1% (p=0.977) after 24 weeks between JAK and TNF. Conclusion The present study provides evidence supporting the JAK and TNF therapy improved similarly the inflammatory synovitis of US findings. Disclosure of Interests None declared
AB1159 HYDROXYCHLOROQUINE SHORTAGE AND ITS RELATION TO ANXIETY LEVEL AND DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS DURING COVID-19 PANDEMIC
Authors: M. H. Abu-Zaid, H. Eitta, A. Moshrif, D. Abdeldaim, N. EL Ghobashy
Journal: Annals of the Rheumatic Diseases (2022)

Background Concerns of hydroxychloroquine (HCQ) shortage for patients with rheumatic diseases are growing during the era of COVID-19 pandemic as it was assigned in some treatment protocols. Its nonavailability may impact the disease management especially in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Objectives To evaluate the shortage of HCQ in patients with RA and SLE and its impact on patients anxiety and disease activity. Methods 219 RA patients (according to 2010 ACR/EULAR criteria) and 200 SLE patients (according to 2012 SLICC criteria) were recruited in the study. Demographic and clinical features of the patients together with the current disease activity parameters (CDAI and SELENA/SLEADI) were prospectively collected. previous disease activity measures were collected from the patients records before hydroxychloroquine shortage. Patient’s anxiety was measured using Hamilton anxiety rating scale. Results A total of 419 patients divided into two groups, Group (1); 219 RA patients with mean age 45.6±9.6 years, disease duration 45.5±32.8 months with female predominance (63 %). Group (2): 200 SLE patients with mean age 33.8±7.9 years, disease duration 61.2±39.2 months with female predominance (84%). 168 (76.7%) of the RA patients and 128 (64%) of SLE patients reduced or stopped the dose of HCQ due to unavailability. Despite HCQ shortage, there was no significant change in disease activity in RA or SLE patients (P=0.063 and 0.064 respectively). All participants suffered from different levels of anxiety which was positively correlated with HCQ shortage (p= 0.001 and 0.005 for RA and SLE respectively). Conclusion COVID 19 pandemic caused hydroxychloroquine shortage in the majority of patients with RA and SLE with no significant impact on their disease activity. Anxiety was found correlating to HCQ shortage in both diseases more significantly in SLE patients. Disclosure of Interests Mohammed Hassan Abu-Zaid: None declared, Hany Eitta: None declared, Abdelhfeez Moshrif Speakers bureau: Amgen, Jansen and Novartis, Doaa Abdeldaim: None declared, nehal EL Ghobashy: None declared
An Intersectional Approach to Ethnoracial Disparities in Pathways to Care Among Individuals With Psychosis in Coordinated Specialty Care
Authors: Els van der Ven, Nev Jones, Natalie Bareis, Jennifer M. Scodes, Renald Dambreville, Hong Ngo, Chackupurackal M. Mathai, Iruma Bello, Gonzalo Martínez-Alés, Franco Mascayano, Rufina J. Lee, Wim Veling, Deidre M. Anglin, Roberto Lewis-Fernandez, Ezra S. Susser, Michael T. Compton, Lisa B. Dixon, Melanie M. Wall
Journal: JAMA Psychiatry (2022)

Intersecting factors of social position including ethnoracial background may provide meaningful ways to understand disparities in pathways to care for people with a first episode of psychosis.