Highlighted research articles
Journal: Cancer Discovery (2023)

In This Issue| July 07 2023 Highlighted research articles Author & Article Information Online ISSN: 2159-8290 Print ISSN: 2159-8274 ©2023 American Association for Cancer Research2023American Association for Cancer Research Cancer Discov (2023) 13 (7): 1501–1503. https://doi.org/10.1158/2159-8290.CD-13-7-ITI Related Content This is a related article to: Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation This is a related article to: Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid Leukemia This is a related article to: Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell–Intrinsic Dysfunction View more This is a related article to: Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis This is a related article to: A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities This is a related article to: Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC This is a related article to: An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression This is a related article to: Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer This is a related article to: C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3-Mutant Leukemia View less Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record July 7 2023 Citation Highlighted research articles. Cancer Discov 1 July 2023; 13 (7): 1501–1503. https://doi.org/10.1158/2159-8290.CD-13-7-ITI Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Despite the promise of KRASG12C inhibitors, many patients do not experience long-term durable responses on these drugs, so it is critical to identify molecular determinants of response. Negrao, Araujo, Lamberti, Cooper, Akhave, and colleagues evaluated genomic and clinical features that impact KRASG12C inhibitor outcomes in 424 patients with non–small cell lung cancer (NSCLC) treated with either sotorasib or adagrasib and showed that coalterations in KEAP1, SMARCA4, and CDKN2A are associated with poor outcome on these inhibitors. Together, these data propose a patient stratification framework that could improve treatment selection and the tailoring of future combination therapies. See article, p. 1556. Small cell lung cancer (SCLC) remains the most fatal form of lung cancer. In this study, Sivakumar and colleagues present a genomic analysis of the largest cohort of SCLC tumors evaluated to date, encompassing 3,600 tumor specimens. Findings reveal rare cohorts of SCLC with potential... You do not currently have access to this content.