tbuckley/cabot-search huggingface dataset:
Changes in Smoking Cessation–Related Behaviors Among US Adults During the COVID-19 Pandemic
Authors: Priti Bandi, Samuel Asare, Anuja Majmundar, Zheng Xue, Xuesong Han, J. Lee Westmaas, Nigar Nargis, Ahmedin Jemal
Journal: JAMA Network Open (2022)

<h3>Importance</h3> Smoking cessation is an urgent public health priority given that smoking is associated with increased risk of severe COVID-19 outcomes and other diseases. It is unknown how smoking cessation changed nationally during the COVID-19 pandemic. <h3>Objective</h3> To investigate changes in smoking cessation–related behaviors in the US during the COVID-19 pandemic. <h3>Design, Setting, and Participants</h3> This cross-sectional study was conducted using 2011 to 2020 data on 788 008 individuals who had smoked in the past year from the nationally representative Behavioral Risk Factor Surveillance System (BRFSS) survey. Representative retail scanner sales data between January 2017 and July 2021 for 1004 unique nicotine replacement therapy (NRT) universal product codes in 31 US states from NielsenIQ were also used. <h3>Exposures</h3> Calendar year and 4-week sales periods. <h3>Main Outcomes and Measures</h3> Changes in annual self-reported prevalence of past-year quit attempts and recent successful cessation before (ie, 2011-2019) and during (ie, 2020) the COVID-19 pandemic and changes in sales volumes in millions of pieces of nicotine gum, lozenge, and patch brands before (1271 four-week sales periods between January 2017 and February 2020) and during (558 four-week sales periods between March 2020 and July 2021) the COVID-19 pandemic were calculated. <h3>Results</h3> The 2011 to 2020 pooled BRFSS sample (response rate range, 45.2%-49.9%) included 788 008 respondents (243 061 individuals ages 25-44 years [weighted percentage, 42.5%]; 374 519 men [weighted percentage, 55.7%]). For the first time since 2011, annual past-year quit attempt prevalence decreased between 2019 and 2020, from 65.2% (95% CI, 64.5% to 65.9%) to 63.2% (95% CI, 62.3% to 64.0%), with the largest relative decreases among individuals ages 45 to 64 years (61.4% [95% CI, 60.3% to 62.5%] vs 57.7% [95% CI, 56.3% to 59.2%]), those with 2 or more comorbidities (67.1% [95% CI, 66.0% to 68.2%] to 63.0% [95% CI, 61.6% to 64.4%]), and Black individuals (72.5% [95% CI, 70.3 to 74.6] vs 68.4% [95% CI, 65.3% to 71.3%]). Recent successful cessation remained unchanged during 2019 to 2020. Observed mean (SD) 4-week NRT sales volume in the prepandemic period was 105.6 (66.2) million gum pieces, 51.9 (31.6) million lozenges, and 2.0 (1.1) million patches. Compared with expected sales, observed sales during the COVID-19 pandemic were lower by 13.0% (95% CI, –13.7% to –12.3%) for lozenges, 6.4% (95% CI, –7.3% to –5.5%) for patches, and 1.2% (95% CI, –1.7% to –0.7%) for gum. <h3>Conclusions and Relevance</h3> This study found that serious smoking cessation activity among US adults decreased immediately and remained depressed for more than a year during the COVID-19 pandemic. These findings suggest that smokers experiencing disproportionately negative outcomes during the pandemic should be reengaged and assisted in quit attempts.
Trends in Remote Patient Monitoring Use in Traditional Medicare
Authors: Mitchell Tang, Carter H. Nakamoto, Ariel D. Stern, Ateev Mehrotra
Journal: JAMA Internal Medicine (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Ending the constitutional right to abortion in the United States
Authors: Lawrence O Gostin, Rebecca B Reingold
Journal: BMJ (2022)

the US Supreme Court overturned Roe v Wade, a landmark decision that established a constitutional right to abortion before fetal viability.The court's regressive ruling stands in stark contrast to global trends expanding abortion rights.Half of Americans will no longer fully possess human rights to health and bodily integrity, and the ruling will exacerbate already unconscionable health and economic inequities.Reversing a half century of precedent, the Supreme Court ruled in Dobbs v Jackson Women's Health Organization that there is no constitutional right to abortion, which is not "essential to ordered liberty." 1 Constitutional rights to contraception, same sex marriage, and same sex intimacy rely on similar reasoning so could be jeopardised in future rulings.For the first time since it was established in 1789, the court withdrew a fundamental human right.Public trust in the court has plummeted.Abortion will be banned or severely restricted in at least half the states, and access to essential health services will depend entirely on where a person lives.
The Role of Primary Care Clinicians in Protecting Access to Abortion Services
Authors: Miriam R. Singer, Deborah Bartz, Lydia E. Pace
Journal: JAMA Internal Medicine (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Lenalidomide therapy for primary myelodysplastic syndromes with isolated del(5q): Determinants of response and survival in a real‐world setting
Authors: Amritpal Singh, Aref Al‐Kali, James M. Foran, Michelle A. Elliott, Kebede Begna, Talha Badar, Nandita Khera, Farah Fleti, Maymona Abdelmagid, Kareen K. Reichard, Rhett P. Ketterling, Animesh Pardanani, Naseema Gangat, Ayalew Tefferi
Journal: American Journal of Hematology (2022)
High-resolution structural variant profiling of myelodysplastic syndromes by optical genome mapping uncovers cryptic aberrations of prognostic and therapeutic significance
Authors: Hui Yang, Guillermo Garcia-Manero, Koji Sasaki, Guillermo Montalban-Bravo, Zhenya Tang, Yue Wei, Tapan Kadia, Kelly Chien, Diana Rush, Ha Nguyen, Awdesh Kalia, Manjunath Nimmakayalu, Carlos Bueso-Ramos, Hagop Kantarjian, L. Jeffrey Medeiros, Rajyalakshmi Luthra, Rashmi Kanagal-Shamanna
Journal: Leukemia (2022)

Chromosome banding analysis (CBA) remains the standard-of-care for structural variant (SV) assessment in MDS. Optical genome mapping (OGM) is a novel, non-sequencing-based technique for high-resolution genome-wide SV profiling (SVP). We explored the clinical value of SVP by OGM in 101 consecutive, newly diagnosed MDS patients from a single-center, who underwent standard-of-care cytogenetic and targeted NGS studies. OGM detected 383 clinically significant, recurrent and novel SVs. Of these, 224 (51%) SVs, seen across 34% of patients, were cryptic by CBA (included rearrangements involving MECOM, NUP98::PRRX2, KMT2A partial tandem duplications among others). SVP decreased the proportion of normal karyotype by 16%, identified complex genomes (17%), chromothripsis (6%) and generated informative results in both patients with insufficient metaphases. Precise gene/exon-level mapping allowed assessment of clinically relevant biomarkers (TP53 allele status, KMT2A-PTD) without additional testing. SV data was complementary to NGS. When applied in retrospect, OGM results changed the comprehensive cytogenetic scoring system (CCSS) and R-IPSS risk-groups in 21% and 17% patients respectively with an improved prediction of prognosis. By multivariate analysis, CCSS by OGM only (not CBA), TP53 mutation and BM blasts independently predicted survival. This is the first and largest study reporting the value of combined SVP and NGS for MDS prognostication.
Balloon pulmonary angioplasty versus riociguat in inoperable chronic thromboembolic pulmonary hypertension (MR BPA): an open-label, randomised controlled trial
Authors: Takashi Kawakami, Hiromi Matsubara, Toshiro Shinke, Kohtaro Abe, Shun Kohsaka, Kazuya Hosokawa, Yu Taniguchi, Hiroto Shimokawahara, Yoshitake Yamada, Masaharu Kataoka, Aiko Ogawa, Mitsushige Murata, Masahiro Jinzaki, Kenichi Hirata, Hiroyuki Tsutsui, Yasunori Sato, Keiichi Fukuda
Journal: The Lancet Respiratory Medicine (2022)
Association and Familial Coaggregation of Childhood-Onset Type 1 Diabetes With Depression, Anxiety, and Stress-Related Disorders: A Population-Based Cohort Study
Authors: Shengxin Liu, Marica Leone, Jonas F. Ludvigsson, Paul Lichtenstein, Brian D’Onofrio, Ann-Marie Svensson, Soffia Gudbjörnsdottir, Sarah E. Bergen, Henrik Larsson, Ralf Kuja-Halkola, Agnieszka Butwicka
Journal: Diabetes Care (2022)

To estimate the association and familial coaggregation of childhood-onset type 1 diabetes with depression, anxiety, and stress-related disorders.This was a population-based cohort study with use of data from Swedish nationwide registers. A total of ∼3.5 million individuals born in Sweden 1973-2007 were linked to their biological parents, full siblings and half-siblings, and cousins. Cox models were used to estimate the association and familial coaggregation of type 1 diabetes with depression, anxiety, and stress-related disorders.Individuals diagnosed with childhood-onset type 1 diabetes (n = 20,005) were found to be at greater risks of all outcomes: any psychiatric diagnosis (adjusted hazard ratio [aHR] 1.66 [95% CI 1.59-1.72]) or specific diagnoses of depression (1.85 [1.76-1.94]), anxiety (1.41[1.33-1.50]), and stress-related disorders (1.75 [1.62-1.89]), as well as use of antidepressants or anxiolytics (1.30 [1.26-1.34]), compared with individuals without type 1 diabetes. Overall, relatives of individuals with type 1 diabetes were at elevated risks of developing these outcomes, with the highest risks seen in parents (aHRs 1.18-1.25), followed by full siblings (aHRs 1.05-1.20), and the magnitudes of risk estimates appear proportional to familial relatedness.These results support existing evidence that children and adolescents with type 1 diabetes are at greater risks of developing depression, anxiety, and stress-related disorders and indicate that shared familial factors might contribute to these elevated risks. Our findings highlight the need for psychological consulting for children and their families in diabetes care. Quantitative and molecular genetic studies are warranted to further understand the etiology of these psychiatric disorders in type 1 diabetes.
Driving Safety After an Acute Illness—This Is Our Lane
Authors: Cary P. Gross, Mark R. Rosekind
Journal: JAMA Internal Medicine (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Development of Resistance-Associated Mutations After Sotrovimab Administration in High-risk Individuals Infected With the SARS-CoV-2 Omicron Variant
Authors: Emma Birnie, Jason J. Biemond, Brent Appelman, Godelieve J. de Bree, Marcel Jonges, Matthijs R. A. Welkers, W. Joost Wiersinga
Journal: JAMA (2022)

This study investigates whether resistance-associated mutations develop after treatment with sotrovimab in high-risk patients infected with the SARS-CoV-2 Omicron variant.
Association of Genetic Variant Linked to Hemochromatosis With Brain Magnetic Resonance Imaging Measures of Iron and Movement Disorders
Authors: Robert Loughnan, Jonathan Ahern, Cherisse Tompkins, Clare E. Palmer, John Iversen, Wesley K. Thompson, Ole Andreassen, Terry Jernigan, Leo Sugrue, Anders Dale, Mary E. T. Boyle, Chun Chieh Fan
Journal: JAMA Neurology (2022)

Hereditary hemochromatosis (HH) is an autosomal recessive genetic disorder that leads to iron overload. Conflicting results from previous research has led some to believe the brain is spared the toxic effects of iron in HH.
Post-COVID-19 Condition
Authors: Ani Nalbandian, Amar D. Desai, Elaine Y. Wan
Journal: Annual Review of Medicine (2022)

An estimated 10-15% of those infected with SARS-CoV-2 may have post-COVID-19 condition. Common lingering signs and symptoms include shortness of breath, fatigue, high heart rate, and memory and cognitive dysfunction even several months after infection, often impacting survivors' quality of life. The prevalence and duration of individual symptoms remain difficult to ascertain due to the lack of standardized research methods across various studies and limited patient follow-up in clinical studies. Nonetheless, data indicate post-COVID-19 condition may occur independent of acuity of initial infection, hospitalization status, age, or pre-existing comorbidities. Risk factors may include female sex and underlying respiratory or psychiatric disease. Supportive therapies to mitigate symptoms remain the mainstay of treatment. Reassuringly, most patients experience a reduction in symptoms by 1 year. The use of a universal case definition and shared research methods will allow for further clarity regarding the pervasiveness of this entity and its long-term health consequences.
Association of Funding Cuts to the Patient Protection and Affordable Care Act Navigator Program With Privately Sponsored Television Advertising
Authors: Rebecca Myerson, David M. Anderson, Laura M. Baum, Erika Franklin Fowler, Sarah E. Gollust, Paul R. Shafer
Journal: JAMA Network Open (2022)

Many individuals eligible for coverage in the Patient Protection and Affordable Care Act (ACA) marketplace remain unenrolled because of information barriers. Whether the private sector or the public sector should conduct outreach to address these barriers is a topic of active debate.
Remote Patient Monitoring—Will More Data Lead to More Health?
Authors: Amol S. Navathe, Aidan Crowley, Joshua M. Liao
Journal: JAMA Internal Medicine (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Recent advances in targeted delivery of non-coding RNA-based therapeutics for atherosclerosis
Authors: Xiaoxin Li, Hongzhao Qi, Weigang Cui, Zhibin Wang, Xiuxiu Fu, Tianxiang Li, Huibo Ma, Yanyan Yang, Tao Yu
Journal: Molecular Therapy (2022)

Cardiovascular disease (CVD) has overtaken infectious illnesses as the leading cause of mortality and disability worldwide. The pathology that underpins CVD is atherosclerosis, characterized by chronic inflammation caused by the accumulation of plaques in the arteries. As our knowledge about the microenvironment of blood vessel walls deepens, there is an opportunity to fine-tune treatments to target the mechanisms driving atherosclerosis more directly. The application of non-coding RNAs (ncRNAs) as biomarkers or intervention targets is increasing. Although these ncRNAs play an important role in driving atherosclerosis and vascular dysfunction, the cellular and extracellular environments pose a challenge for targeted transmission and therapeutic regulation of ncRNAs. Specificity, delivery, and tolerance have hampered the clinical translation of ncRNA-based therapeutics. Nanomedicine is an emerging field that uses nanotechnology for targeted drug delivery and advanced imaging. Recently, nanoscale carriers have shown promising results and have introduced new possibilities for nucleic acid targeted drug delivery, particularly for atherosclerosis. In this review, we discuss the latest developments in nanoparticles to aid ncRNA-based drug development, particularly miRNA, and we analyze the current challenges in ncRNA targeted delivery. In particular, we highlight the emergence of various kinds of nanotherapeutic approaches based on ncRNAs, which can improve treatment options for atherosclerosis.
Endoscopic approach for a pinhole-like benign stenosis in a pancreaticojejunal anastomosis using a double-balloon endoscope with a clear long cap attachment
Authors: Takeshi Kasai, Masaaki Shimatani, Toshiyuki Mitsuyama, Takeshi Yamashina, Masataka Kano, Takakuni Yuba, Makoto Naganuma
Journal: Endoscopy (2022)

The usefulness of therapeutic modalities using double-balloon endoscopy for biliary disease in postoperative patients has been widely reported [1] [2] [3], while papers published about its use in pancreatic disease are scarce, despite an increasing demand for such treatment. This is the first report of successful double-balloon endoscopy-assisted endoscopic retrograde pancreatography (DB-ERP) using a clear long cap for a pinhole-like benign stricture in the pancreaticojejunal anastomosis after pancreaticoduodenectomy.
Will artificial intelligence-assisted colonoscopy work in cancer screening programs?
Authors: Masashi Misawa
Journal: Endoscopy (2022)

Fecal immunochemical testing (FIT) and subsequent colonoscopy are components of cancer screening programs worldwide, the aim being to reduce colorectal cancer (CRC) incidence and mortality. However, FIT-based screening schemes do not prevent all cancers: some patients who have undergone FIT-based colonoscopies develop post-colonoscopy colorectal cancer (PCCRC). One of the main causes of PCCRC is poor-quality colonoscopy. The adenoma detection rate (ADR) is an established quality indicator for primary screening colonoscopy [1], this rate being inversely associated with the incidence of PCCRC. Whether ADR is an equivalent indicator of quality in post-FIT colonoscopies and primary screening colonoscopies has not yet been established. However, it is generally believed that ADR serves as a reliable quality indicator in post-FIT colonoscopies [2].
Anatomic and hemodynamic findings during endoscopic ultrasound-guided angiography of gastric varices: a note of caution for endoscopic ultrasound-guided therapy
Authors: Rafael Romero-Castro, Victoria Alejandra Jimenez-Garcia, Atsushi Irisawa, Isabel Carmona-Soria, Angel Caunedo-Alvarez, Anthony Yuen Bun Teoh, Marc Giovannini
Journal: Endoscopy (2022)

Endoscopic ultrasound (EUS)-guided therapy of gastric varices, first reported as the use of a cyanoacrylate (CYA) injection [1], now includes the deployment of coils without CYA [2] and the combined method, involving deployment of one to two coils followed by an injection of CYA [3]. Regardless of the method used, EUS-guided therapy of gastric varices is increasingly performed because of its safety profile and accuracy. EUS-guided angiography can be used to assess fluidodynamics, the anatomy of gastric varices, and gastrorenal shunt (GRS) patency.
Endoscopic full-thickness resection with double-layer closure by endoscopic hand suturing for a gastric subepithelial tumor
Authors: Osamu Goto, Eriko Koizumi, Kazutoshi Higuchi, Takeshi Onda, Jun Omori, Naohiko Akimoto, Katsuhiko Iwakiri
Journal: Endoscopy (2022)

Gastric endoscopic full-thickness resection (EFTR) requires secure full-thickness defect closure [1]. Here, we report a successful case of EFTR with endoscopic hand suturing that provided a double-layer closure [2] [3] [4].
Diagnostic challenge: Mirizzi syndrome with anomalous pancreaticobiliary junction
Authors: Tingting Yu, Yaoting Li, Suning Hou, Lichao Zhang, Jiao Tian, Senlin Hou
Journal: Endoscopy (2022)

A 35-year-old man was admitted to our hospital with abdominal pain after eating. A double bile duct structure was revealed by magnetic resonance cholangiopancreatography. The relationship and alignment of the double bile ducts appeared to be poorly represented ([Fig. 1]). Endoscopic retrograde cholangiopancreatography (ERCP) was performed, and showed two separate openings in the zone of the major duodenal papilla ([Fig. 2], [Video 1]). The cholangiogram revealed that the patient had two common bile ducts (CBDs) that converged in the middle section of the bile duct, and the stones were disclosed in both ducts. Meanwhile, the pancreatic duct converged into the left CBD ([Fig. 3]). We diagnosed type II double common bile duct (DCBD) [1] with anomalous pancreaticobiliary junction (APBJ) and cholelithiasis ([Fig. 4 a]).