tbuckley/cabot-search huggingface dataset:
Germline predisposition traits in allogeneic hematopoietic stem-cell transplantation for myelodysplastic syndromes: a survey-based study and position paper on behalf of the Chronic Malignancies Working Party of the EBMT
Authors: Carmelo Gurnari, Marie Robin, Lucy A Godley, Joanna Drozd-Sokołowska, Marcin W Włodarski, Kavita Raj, Francesco Onida, Nina Worel, Fabio Ciceri, Selim Carbacioglu, Michelle Kenyon, Mahmoud Aljurf, Carmem Bonfim, Hideki Makishima, Charlotte Niemeyer, Pierre Fenaux, Armin Zebisch, Nada Hamad, Yves Chalandon, Eva Hellström-Lindberg, Maria Teresa Voso, Cristina Mecucci, Fernando Barroso Duarte, Marie Sebert, Flore Sicre de Fontbrune, Jean Soulier, Akiko Shimamura, R Coleman Lindsley, Jarosław P Maciejewski, Rodrigo T Calado, Ibrahim Yakoub-Agha, Donal P McLornan
Journal: The Lancet Haematology (2023)
Economic Evaluation of a Nonmedical Financial Assistance Program on Missed Treatment Appointments Among Adults With Cancer
Authors: Caitlin B. Biddell, Lisa P. Spees, Justin G. Trogdon, Erin E. Kent, Donald L. Rosenstein, Rebekah S.M. Angove, Cindy D. Rogers, Stephanie B. Wheeler
Journal: Journal of Clinical Oncology (2023)

We retrospectively evaluated the clinical and economic impact of a program providing nonmedical financial assistance on missed treatment appointments among patients receiving cancer treatment at a large, Southeastern public hospital system.
Effectiveness of the quadrivalent live attenuated influenza vaccine against influenza-related hospitalisations and morbidity among children aged 2 to 6 years in Denmark: a nationwide cohort study emulating a target trial
Authors: Helene Kildegaard, Lars Christian Lund, Anton Pottegård, Lone Graff Stensballe
Journal: The Lancet Child & Adolescent Health (2023)
Effects of a Rho-Kinase Inhibitor in Patients With Pulmonary Hypertension Due to Left Heart Disease
Authors: Masaki Ishiyama, Naoki Fujimoto, Shusuke Fukuoka, Taku Omori, Keishi Moriwaki, Yoshito Ogihara, Shiro Nakamori, Tairo Kurita, Ryuji Okamoto, Kaoru Dohi
Journal: JACC Heart Failure (2023)
Adherence, safety, and choice of the monthly dapivirine vaginal ring or oral emtricitabine plus tenofovir disoproxil fumarate for HIV pre-exposure prophylaxis among African adolescent girls and young women: a randomised, open-label, crossover trial
Authors: Gonasagrie Nair, Connie Celum, Daniel Szydlo, Elizabeth R Brown, Carolyne A Akello, Rita Nakalega, Pippa Macdonald, Gakiema Milan, Thesla Palanee-Phillips, Krishnaveni Reddy, Eunice Tahuringana, Felix Muhlanga, Clemensia Nakabiito, Linda-Gail Bekker, Bekezela Siziba, Sharon L Hillier, Jared M Baeten, Morgan Garcia, Sherri Johnson, Tara McClure, Lisa Levy, Edward Livant, Cindy Jacobson, Lydia Soto-Torres, Ariane van der Straten, Sybil Hosek, James F Rooney, John Steytler, Katherine Bunge, Urvi Parikh, Craig Hendrix, Peter Anderson, Kenneth Ngure
Journal: The Lancet HIV (2023)
Long-term outcomes with biodegradable polymer sirolimus-eluting stents versus durable polymer everolimus-eluting stents in ST-segment elevation myocardial infarction: 5-year follow-up of the BIOSTEMI randomised superiority trial
Authors: Juan F Iglesias, Marco Roffi, Sylvain Losdat, Olivier Muller, Sophie Degrauwe, David J Kurz, Laurent Haegeli, Daniel Weilenmann, Christoph Kaiser, Maxime Tapponnier, Stéphane Cook, Florim Cuculi, Dik Heg, Stephan Windecker, Thomas Pilgrim
Journal: The Lancet (2023)
CTPS1 is a novel therapeutic target in multiple myeloma which synergizes with inhibition of CHEK1, ATR or WEE1
Authors: Christina Pfeiffer, Alexander M. Grandits, Hélène Asnagli, Anja Schneller, Julia Huber, Niklas Zojer, Martin Schreder, Andrew E. Parker, Arnold Bolomsky, Philip A. Beer, Heinz Ludwig
Journal: Leukemia (2023)
Injury mechanisms and situational patterns of severe lower limb muscle injuries in male professional football (soccer) players: a systematic video analysis study on 103 cases
Authors: Francesco Della Villa, Bruno Massa, Antonio Bortolami, Gianni Nanni, Jesus Olmo, Matthew Buckthorpe
Journal: British Journal of Sports Medicine (2023)

The objective of this study is to describe the mechanism of injury and situational patterns (based on ball possession and playing action leading to injury) of severe (lay-off time >28 days) lower limb muscle injuries in professional male football (soccer) players during match play.Players experiencing a severe muscle injury of the lower limb during Italian first (Serie A) division male football matches over three consecutive seasons (2018-2021) were identified. Video footage was obtained and three raters independently categorised injury mechanism and situational patterns using a standardised checklist. Injury epidemiology (month), timing of injuries within the match and location of injuries on the pitch were also examined.We identified 121 lower limb severe muscle injuries. Videos of sufficient quality were available for 103 (85%) cases, including 61 (60%) hamstring, 17 (16%) calf, 16 (15%) adductor and 9 (9%) quadricep muscle injuries. Nearly two-thirds of injuries involved the dominant/kicking leg (n=65, 63%). Eighty-five (83%) injuries were non-contact and 18 (17%) indirect contact. Four main situational patterns were identified and accounted for 88% of injuries: (1) running/acceleration (n=35, 34%); (2) closed kinetic chain stretching (n=21, 20%); (3) open kinetic chain stretching (n=19, 18%) and (4) kicking (n=16, 16%), with differences between muscle groups. 71% of injuries occurred in the first half of the match (p<0.01), with a gradual increase through the first half.Most severe muscle injuries during football matches were non-contact and occurred in the first half during running/acceleration, open and closed kinetic chain stretching, or kicking.
Exercise-induced circular RNA circUtrn is required for cardiac physiological hypertrophy and prevents myocardial ischaemia–reperfusion injury
Authors: Lijun Wang, Jingyi Feng, Xing Feng, Danni Meng, Xuan Zhao, Jiaqi Wang, Pujiao Yu, Gui-e Xu, Meiyu Hu, Tianhui Wang, H Immo Lehmann, Guoping Li, Joost P G Sluijter, Junjie Xiao
Journal: Cardiovascular Research (2023)

Abstract Aims Regular exercise training benefits cardiovascular health and effectively reduces the risk for cardiovascular disease. Circular RNAs (circRNAs) play important roles in cardiac pathophysiology. However, the role of circRNAs in response to exercise training and biological mechanisms responsible for exercise-induced cardiac protection remain largely unknown. Methods and results RNA sequencing was used to profile circRNA expression in adult mouse cardiomyocytes that were isolated from mice with or without exercise training. Exercise-induced circRNA circUtrn was significantly increased in swimming-trained adult mouse cardiomyocytes. In vivo, circUtrn was found to be required for exercise-induced physiological cardiac hypertrophy. circUtrn inhibition abolished the protective effects of exercise on myocardial ischaemia–reperfusion remodelling. circUtrn overexpression prevented myocardial ischaemia–reperfusion-induced acute injury and pathological cardiac remodelling. In vitro, overexpression of circUtrn promoted H9 human embryonic stem cell–induced cardiomyocyte growth and survival via protein phosphatase 5 (PP5). Mechanistically, circUtrn directly bound to PP5 and regulated the stability of PP5 in a ubiquitin–proteasome-dependent manner. Hypoxia-inducible factor 1α–dependent splicing factor SF3B1 acted as an upstream regulator of circUtrn in cardiomyocytes. Conclusion The circRNA circUtrn is upregulated upon exercise training in the heart. Overexpression of circUtrn can prevent myocardial I/R-induced injury and pathological cardiac remodelling.
Health Status After Transcatheter Tricuspid-Valve Repair in Patients With Severe Tricuspid Regurgitation
Authors: Suzanne V Arnold, Scott Goates, Paul Sorajja, David H Adams, Ralph Stephan von Bardeleben, Samir R Kapadia, David J Cohen
Journal: Journal of the American College of Cardiology (2023)

In the TRILUMINATE Pivotal (Trial to Evaluate Cardiovascular Outcomes in Patients Treated with the Tricuspid Valve Repair System Pivotal), tricuspid transcatheter edge-to-edge repair (T-TEER) reduced tricuspid regurgitation (TR) and improved health status compared with medical therapy alone with no benefit on heart failure hospitalizations or survival.
Hepatocellular carcinoma risk in sub-Saharan African and Afro-Surinamese individuals with chronic hepatitis B living in Europe
Authors: Lesley A. Patmore, Kirsi M.A. van Eekhout, Maria Buti, Özgur.M. Koc, Kosh Agarwal, Rob J. de Knegt, Harry L.A. Janssen, Marc van der Valk, Faydra I. Lieveld, Bettina E. Hansen, Matthijs Kramer, Joep de Bruijne, Mark A.A. Claassen, Colette Smit, Rob A. de Man, Bart Takkenberg, Ivana Carey, Milan J. Sonneveld
Journal: Journal of Hepatology (2023)

Sub-Saharan African (SSA) ethnicity has been associated with a higher risk of hepatocellular carcinoma (HCC) among individuals with chronic hepatitis B in cross-sectional studies. However, the incidence of HCC and performance of HCC risk scores in this population are unknown.
Helmet continuous positive airway pressure for patients’ transport using a single oxygen cylinder: A bench study
Authors: N. Capsoni, F. Zadek, D. Privitera, G. Parravicini, G.V. Zoccali, F. Galbiati, M. Bombelli, R. Fumagalli, T. Langer
Journal: Pulmonology (2023)

Continuous positive airway pressure (CPAP) is frequently used to treat patients with acute respiratory failure in out-of-hospital settings. Compared to a facemask, the helmet has many advantages for the patient but requires a minimum gas flow of 60 L/min to avoid CO2 rebreathing. The aim of the present bench study was to evaluate the performance of four Venturi devices, connected to a single oxygen cylinder, in delivering helmet-CPAP with clinically relevant gas flow, fraction of inspired oxygen (FiO2), and positive end-expiratory pressure (PEEP) values. Three double-inlet Venturi systems (EasyVent, Ventuplus, Compact-HAR) were connected to full 5-L oxygen cylinders using a double flowmeter, and their oxygen requirements to reach different setups (flow 60-80 L/min; FiO2 0.4-0.5-0.6, PEEP 7.5-10-12.5 cmH2O) were tested. The fourth Venturi system (O2-MAX) was directly attached to the tank, and the flow and FiO2 delivered at preset FiO2 0.3 and 0.6 were recorded. The runtime of the cylinder was assessed. EasyVent, Ventuplus, and O2-MAX were able to deliver helmet-CPAP with clinically useful setups when connected to a single oxygen cylinder, while Compact-HAR did not. The runtime of the cylinders ranged between 28 and 60 minutes according to the preset flow and FiO2. The delivered gas flow decreased slowly and linearly with the drop in cylinder pressure until its exhaustion. Helmet-CPAP might be provided using portable Venturi systems connected to an oxygen cylinder, but not all of them are able to deliver it. The use of a double flowmeter allows delivery of both high flow and high FiO2 when double-inlet Venturi systems are used. Due to the flow drop observed during the cylinder consumption, a flow >60 L/min should be set when helmet-CPAP is started. Considering the flow drop phenomenon, the estimated duration of the tank runtime can be used with a margin of safety when planning patient transport.
Toward a New Paradigm of Genomics Research—Celebration of the 20th Anniversary of Beijing Institute of Genomics
Authors: Zhang Zhang, Songnian Hu, Jun Yu
Journal: Genomics Proteomics & Bioinformatics (2023)

Abstract Twenty years after the completion and forty years after the proposal of the Human Genome Project (HGP), genomics, together with its twin field — bioinformatics, has entered a new paradigm, where its bioscience-related, discipline-centric applications have been creating many new research frontiers. Beijing Institute of Genomics (BIG), now also known as China National Center for Bioinformation (CNCB), will play key roles in supporting and participating in these frontier research activities. On the 20th anniversary of the establishment of BIG, we provide a brief retrospective of its historic events and ascertain strategic research directions with a broader vision for future genomics, where digital genome, digital medicine, and digital health are so structured to meet the needs of human life and healthcare, as well as their related metaverses.
Next Generation, Modifiable Cardiometabolic Biomarkers: Mitochondrial Adaptation and Metabolic Resilience: A Scientific Statement From the American Heart Association
Authors: Michele Mietus-Snyder, Amanda M. Perak, Susan Cheng, Laura L. Hayman, Norrisa Haynes, Peter J. Meikle, Svati H. Shah, Shakira F. Suglia
Journal: Circulation (2023)

Cardiometabolic risk is increasing in prevalence across the life span with disproportionate ramifications for youth at socioeconomic disadvantage. Established risk factors and associated disease progression are harder to reverse as they become entrenched over time; if current trends are unchecked, the consequences for individual and societal wellness will become untenable. Interrelated root causes of ectopic adiposity and insulin resistance are understood but identified late in the trajectory of systemic metabolic dysregulation when traditional cardiometabolic risk factors cross current diagnostic thresholds of disease. Thus, children at cardiometabolic risk are often exposed to suboptimal metabolism over years before they present with clinical symptoms, at which point life-long reliance on pharmacotherapy may only mitigate but not reverse the risk. Leading-edge indicators are needed to detect the earliest departure from healthy metabolism, so that targeted, primordial, and primary prevention of cardiometabolic risk is possible. Better understanding of biomarkers that reflect the earliest transitions to dysmetabolism, beginning in utero, ideally biomarkers that are also mechanistic/causal and modifiable, is critically needed. This scientific statement explores emerging biomarkers of cardiometabolic risk across rapidly evolving and interrelated "omic" fields of research (the epigenome, microbiome, metabolome, lipidome, and inflammasome). Connections in each domain to mitochondrial function are identified that may mediate the favorable responses of each of the omic biomarkers featured to a heart-healthy lifestyle, notably to nutritional interventions. Fuller implementation of evidence-based nutrition must address environmental and socioeconomic disparities that can either facilitate or impede response to therapy.
GTP Signaling Links Metabolism, DNA Repair, and Responses to Genotoxic Stress
Authors: Weihua Zhou, Zitong Zhao, Angelica Lin, John Z. Yang, Jie Xu, Kari Wilder-Romans, Annabel Yang, Jing Li, Sumeet Solanki, Jennifer M. Speth, Natalie Walker, Andrew J. Scott, Lu Wang, Bo Wen, Anthony Andren, Li Zhang, Ayesha U. Kothari, Yangyang Yao, Erik R. Peterson, Navyateja Korimerla, Christian K. Werner, Alexander Ullrich, Jessica Liang, Janna Jacobson, Sravya Palavalasa, Alexandra M. O’Brien, Ameer L. Elaimy, Sean P. Ferris, Shuang G. Zhao, Jann N. Sarkaria, Balázs Győrffy, Shuqun Zhang, Wajd N. Al-Holou, Yoshie Umemura, Meredith A. Morgan, Theodore S. Lawrence, Costas A. Lyssiotis, Marc Peters-Golden, Yatrik M. Shah, Daniel R. Wahl
Journal: Cancer Discovery (2023)

How cell metabolism regulates DNA repair is incompletely understood. Here, we define a GTP-mediated signaling cascade that links metabolism to DNA repair and has significant therapeutic implications. GTP, but not other nucleotides, regulates the activity of Rac1, a guanine nucleotide-binding protein, which promotes the dephosphorylation of serine 323 on Abl-interactor 1 (Abi-1) by protein phosphatase 5 (PP5). Dephosphorylated Abi-1, a protein previously not known to activate DNA repair, promotes nonhomologous end joining. In patients and mouse models of glioblastoma, Rac1 and dephosphorylated Abi-1 mediate DNA repair and resistance to standard-of-care genotoxic treatments. The GTP-Rac1-PP5-Abi-1 signaling axis is not limited to brain cancer, as GTP supplementation promotes DNA repair and Abi-1-S323 dephosphorylation in nonmalignant cells and protects mouse tissues from genotoxic insult. This unexpected ability of GTP to regulate DNA repair independently of deoxynucleotide pools has important implications for normal physiology and cancer treatment. A newly described GTP-dependent signaling axis is an unexpected link between nucleotide metabolism and DNA repair. Disrupting this pathway can overcome cancer resistance to genotoxic therapy while augmenting it can mitigate genotoxic injury of normal tissues. This article is featured in Selected Articles from This Issue, p. 5.
A randomized, double‐blind, sham‐controlled, clinical trial of auricular vagus nerve stimulation for the treatment of active rheumatoid arthritis: comment on the article by Baker et al
Authors: Cynthia Aranow, Timir Datta‐Chadhuri, Ulf Andersson, Sangeeta Chavan, Kevin J. Tracey
Journal: Arthritis & Rheumatology (2023)

Disclosure form Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Compounded inequality: racial disparity and Down syndrome – Authors' reply
Authors: R Asaad Baksh, Sarah E Pape, Andre Strydom
Journal: The Lancet Public Health (2023)

We thank Eimear McGlinchey and colleagues for their comments on our Article.1 Ethnicity is an important factor to consider when examining health inequities, and there is an urgent need to address ethnicity-related disparities in health care that could lead to differences in health outcomes.
FXR agonists for MASH therapy: Lessons and perspectives from obeticholic acid
Authors: Kang Wang, Yuecan Zhang, Guangji Wang, Haiping Hao, Hong Wang
Journal: Medicinal Research Reviews (2023)

Abstract Nonalcoholic fatty liver disease, also called metabolic dysfunction‐associated steatotic liver disease, is the most common liver disease worldwide and has no approved pharmacotherapy. Due to its beneficial effects on metabolic regulation, inflammation suppression, cell death prevention, and fibrogenesis inhibition, farnesoid X receptor (FXR) is widely accepted as a promising therapeutic target for nonalcoholic steatosis (NASH) or called metabolic dysfunction‐associated steatohepatitis (MASH). Many FXR agonists have been developed for NASH/MASH therapy. Obeticholic acid (OCA) is the pioneering frontrunner FXR agonist and the first demonstrating success in clinical trials. Unfortunately, OCA did not receive regulatory approval as a NASH pharmacotherapy because its moderate benefits did not outweigh its safety risks, which may cast a shadow over FXR‐based drug development for NASH/MASH. This review summarizes the milestones in the development of OCA for NASH/MASH and discuss its limitations, including moderate hepatoprotection and the undesirable side effects of dyslipidemia, pruritus, cholelithiasis, and liver toxicity risk, in depth. More importantly, we provide perspectives on FXR‐based therapy for NASH/MASH, hoping to support a successful bench‐to‐clinic transition.
A Case of S1Q3T3—A Classic Nonspecific Electrocardiogram Finding
Authors: Rohit Pillai, Jason D. Matos
Journal: JAMA Internal Medicine (2023)

This case report describes a patient in their 40s with a history of end-stage kidney disease secondary to hypertension and diabetes who presented with fatigue, cough, weakness, and dyspnea on exertion and was subsequently diagnosed with acute disseminated cryptococcal infection.
Navigating the Omics Frontier: Challenges, Opportunities, and the Future of Precision Nephrology
Authors: Markus M. Rinschen, Mark A. Knepper
Journal: Journal of the American Society of Nephrology (2023)

1Department of Biomedicine, Aarhus University, Aarhus, Denmark 2III Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany 3Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany 4Aarhus Institute of Advanced Studies, Aarhus University, Aarhus, Denmark 5Epithelial Systems Biology Laboratory, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland Correspondence: Markus M. Rinschen, Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000 Aarhus, Denmark. Email: [email protected] Published online ahead of print. Publication date available at www.jasn.org.
Oxygen‐Generating Hydrogels as Oxygenation Therapy for Accelerated Chronic Wound Healing
Authors: Zhixuan Yang, Kaixuan Ren, Yehao Chen, Xinyan Quanji, Chengfeng Cai, Jingbo Yin
Journal: Advanced Healthcare Materials (2023)

Abstract Hypoxia in chronic wounds impairs the activities of reparative cells, resulting in tissue necrosis, bacterial infections, decreased angiogenesis, and delayed wound healing. To achieve effective oxygenation therapy and restore oxygen homeostasis, oxygen‐generating hydrogels based on different oxygen sources have been developed to release dissolved oxygen in the wound bed, which not only alleviate hypoxia, but also accelerate chronic wound healing. This review first discusses the vital role of oxygen and hypoxia in the wound healing process. The advancements in oxygen‐generating hydrogels, which produce oxygen through the decomposition of hydrogen peroxide, metal peroxides, glucose‐activated cascade reactions, and photosynthesis of algae microorganisms for chronic wound healing, are discussed and summarized. The therapeutic effects and challenges of using oxygen‐generating hydrogels for the clinical treatment of chronic wounds are concluded and prospected.
Doctor Versus Artificial Intelligence: Patient and Physician Evaluation of Large Language Model Responses to Rheumatology Patient Questions in a <scp>Cross‐Sectional</scp> Study
Authors: Carrie Ye, Elric Zweck, Zechen Ma, Justin Smith, Steven Katz
Journal: Arthritis & Rheumatology (2023)

Objective The objective of the current study was to assess the quality of large language model (LLM) chatbot versus physician‐generated responses to patient‐generated rheumatology questions. Methods We conducted a single‐center cross‐sectional survey of rheumatology patients (n = 17) in Edmonton, Alberta, Canada. Patients evaluated LLM chatbot versus physician‐generated responses for comprehensiveness and readability, with four rheumatologists also evaluating accuracy by using a Likert scale from 1 to 10 (1 being poor, 10 being excellent). Results Patients rated no significant difference between artificial intelligence (AI) and physician‐generated responses in comprehensiveness (mean 7.12 ± SD 0.99 vs 7.52 ± 1.16; P = 0.1962) or readability (7.90 ± 0.90 vs 7.80 ± 0.75; P = 0.5905). Rheumatologists rated AI responses significantly poorer than physician responses on comprehensiveness (AI 5.52 ± 2.13 vs physician 8.76 ± 1.07; P &lt; 0.0001), readability (AI 7.85 ± 0.92 vs physician 8.75 ± 0.57; P = 0.0003), and accuracy (AI 6.48 ± 2.07 vs physician 9.08 ± 0.64; P &lt; 0.0001). The proportion of preference to AI‐ versus physician‐generated responses by patients and physicians was 0.45 ± 0.18 and 0.15 ± 0.08, respectively ( P = 0.0106). After learning that one answer for each question was AI generated, patients were able to correctly identify AI‐generated answers at a lower proportion compared to physicians (0.49 ± 0.26 vs 0.97 ± 0.04; P = 0.0183). The average word count of AI answers was 69.10 ± 25.35 words, as compared to 98.83 ± 34.58 words for physician‐generated responses ( P = 0.0008). Conclusion Rheumatology patients rated AI‐generated responses to patient questions similarly to physician‐generated responses in terms of comprehensiveness, readability, and overall preference. However, rheumatologists rated AI responses significantly poorer than physician‐generated responses, suggesting that LLM chatbot responses are inferior to physician responses, a difference that patients may not be aware of. image