tbuckley/cabot-search huggingface dataset:
Treatment alternatives for the rehabilitation of the posterior edentulous maxilla
Authors: Gustavo Avila‐Ortiz, Dániel Vegh, Khaled Mukaddam, Pablo Galindo‐Moreno, Bjarni Pjetursson, Michael Payer
Journal: Periodontology 2000 (2023)

Abstract Rehabilitation of the edentulous maxilla with implant‐supported fixed dental prostheses can represent a significant clinical challenge due to limited bone availability and surgical access, among other factors. This review addresses several treatment options to replace missing teeth in posterior maxillary segments, namely the placement of standard implants in conjunction with maxillary sinus floor augmentation, short implants, tilted implants, and distal cantilever extensions. Pertinent technical information and a concise summary of relevant evidence on the reported outcomes of these different therapeutic approaches are presented, along with a set of clinical guidelines to facilitate decision‐making processes and optimize the outcomes of therapy.
Use of 18F-PSMA PET to Distinguish Cerebral Radiation Necrosis From Tumor Recurrence
Authors: Sampanna Jung Rayamajhi, Maria Rosana Ponisio, Barry Siegel
Journal: Clinical Nuclear Medicine (2023)

Brain metastasis in prostate adenocarcinoma is extremely rare and usually arises in the setting of widespread osseous and visceral metastases. Surgical resection and radiation therapy, including stereotactic radiosurgery, are the mainstays of treatment for brain metastasis. Radiation necrosis is a common complication of radiotherapy for brain metastasis, and distinguishing it from tumor recurrence by MRI is difficult because of overlapping findings. We present a 73-year-old man with prostate cancer with a solitary brain metastasis where PET with 18 F-piflufolostat helped detect disease recurrence in the setting of ambiguous MRI findings.
Outcomes of World Health Organization–defined Severe Respiratory Distress without Shock in Adults in Sub-Saharan Africa
Authors: Bickey H. Chang, Susan A. Adakun, Mary A. Auma, Patrick Banura, Albert Majwala, Amir A. Mbonde, Elizabeth Rogawski McQuade, Richard Ssekitoleko, Mark Conaway, Christopher C. Moore, Ben Andrews, Tim Baker, John A. Crump, Martin P. Grobusch, Michaela A. M. Huson, Shevin T. Jacob, Jamie Rylance, India Wheeler, Olamide D. Jarrett, John Kellett, Matthew Rubach, John Schieffelin
Journal: American Journal of Respiratory and Critical Care Medicine (2023)

"Outcomes of WHO Defined Severe Respiratory Distress without Shock in Adults in Sub-Saharan Africa ." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
Epigenetic regulation of vascular smooth muscle cell phenotypic switch and neointimal formation by PRMT5
Authors: Ni Zhu, Zhi-Fu Guo, Kyosuke Kazama, Bing Yi, Nopprarat Tongmuang, Huijuan Yao, Ruifeng Yang, Chen Zhang, Yongwen Qin, Lin Han, Jianxin Sun
Journal: Cardiovascular Research (2023)

Abstract Aims Phenotypic transition of vascular smooth muscle cells (VSMCs) from a contractile to a synthetic state is involved in the development of cardiovascular diseases, including atherosclerosis, hypertension, and post-angioplasty restenosis. Arginine methylation catalyzed by protein arginine methyltransferases (PRMTs) has been implicated in multiple cellular processes, however, its role in VSMC biology remains undetermined. The objective of this study was to determine the role of PRMTs in VSMC phenotypic switch and vascular remodelling after injury. Methods and results Our results show that PRMT5 is the most abundantly expressed PRMT in human aortic SMCs, and its expression is up-regulated in platelet-derived growth factor (PDGF)-stimulated VSMCs, human atherosclerotic lesions, and rat carotid arteries after injury, as determined by western blot and immunohistochemical staining. PRMT5 overexpression inhibits the expression of SMC marker genes and promotes VSMC proliferation and migration, while silencing PRMT5 exerts the opposite effects. Mechanistically, we found that PRMT5 overexpression led to histone di-methylation of H3R8 and H4R3, which in turn attenuates acetylation of H3K9 and H4, thus limiting recruitment of the SRF/myocardin complexes to the CArG boxes of SMC marker genes. Furthermore, both SMC-specific deletion of PRMT5 in mice and local delivery of lentivirus expressing shPRMT5 to rat carotid arteries significantly attenuated neointimal formation after injury. Likewise, pharmacological inhibition of PRMT5 by EPZ015666 markedly inhibited carotid artery ligation-induced neointimal formation in mice. Conclusions Our results identify PRMT5 as a novel regulator in VSMC phenotypic switch and suggest that inhibition of PRMT5 may represent an effective therapeutic strategy for proliferative vascular diseases.
Effect of Postal-Mailed Nicotine Patches on Tobacco Cessation Among Smokers in Rural Canada
Authors: John A. Cunningham, Michael Chaiton, Scott T. Leatherdale, Alexandra Godinho, Christina Schell
Journal: JAMA Network Open (2023)

This randomized clinical trial assesses the efficacy of mailed nicotine patches on cessation of tobacco smoking among adults in rural Canada.
Colorectal cancer and gut microbiota studies in China
Authors: Zikai Wang, Wanyue Dan, Nana Zhang, Jingyuan Fang, Yunsheng Yang
Journal: Gut Microbes (2023)

Colorectal cancer (CRC) is the third most common malignant tumor worldwide. The incidence and mortality rates of CRC have been increasing in China, possibly due to economic development, lifestyle, and dietary changes. Evidence suggests that gut microbiota plays an essential role in the tumorigenesis of CRC. Gut dysbiosis, specific pathogenic microbes, metabolites, virulence factors, and microbial carcinogenic mechanisms contribute to the initiation and progression of CRC. Gut microbiota biomarkers have potential translational applications in CRC screening and early diagnosis. Gut microbiota-related interventions could improve anti-tumor therapy's efficacy and severe intestinal toxic effects. Chinese researchers have made many achievements in the relationship between gut microbiota and CRC, although some challenges remain. This review summarizes the current evidence from China on the role of gut microbiota in CRC, mainly including the gut microbiota characteristics, especially Fusobacterium nucleatum and Parvimonas micra, which have been identified to be enriched in CRC patients; microbial pathogens such as F. nucleatum and enterotoxigenic Bacteroides fragilis, and P. micra, which Chinese scientists have extensively studied; diagnostic biomarkers especially F. nucleatum; therapeutic effects, including microecological agents represented by certain Lactobacillus strains, fecal microbiota transplantation, and traditional Chinese medicines such as Berberine and Curcumin. More efforts should be focused on exploring the underlying mechanisms of microbial pathogenesis of CRC and providing novel gut microbiota-related therapeutic and preventive strategies.
Data Extraction and Handling Issues on Evidence Synthesis of Risk of Immunoglobulin E–Mediated Food Allergy
Authors: Yu-Tian Xiao, Jingda Cai, Guo-Fu Li
Journal: JAMA Pediatrics (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Excess Death Rates for Republican and Democratic Registered Voters in Florida and Ohio During the COVID-19 Pandemic
Authors: Jacob Wallace, Paul Goldsmith-Pinkham, Jason L. Schwartz
Journal: JAMA Internal Medicine (2023)

There is evidence that Republican-leaning counties have had higher COVID-19 death rates than Democratic-leaning counties and similar evidence of an association between political party affiliation and attitudes regarding COVID-19 vaccination; further data on these rates may be useful.
Consumption of Soft Drinks and Overweight and Obesity Among Adolescents in 107 Countries and Regions
Authors: Huan Hu, Jing Song, Graham A. MacGregor, Feng J. He
Journal: JAMA Network Open (2023)

Soft drink consumption is associated with weight gain in children and adolescents, but little is known about the association between soft drink consumption and prevalence of the overweight and obesity in adolescents.To investigate the association of soft drink consumption with overweight and obesity in adolescents enrolled in school (hereafter, school-going adolescents) using country-level and individual-level data.This cross-sectional study used data from 3 cross-sectional studies including 107 countries and regions that participated in the Global School-Based Student Health Survey (2009-2017), the European Health Behavior in School-Aged Children study (2017-2018), and the US Youth Risk Behavior Survey (2019).Daily soft drink consumption (consuming soft drinks 1 or more times per day or not).Overweight and obesity defined by the World Health Organization Growth Reference Data.Among the 107 countries and regions, 65 were low- and middle-income, and 42 were high-income countries and regions, with a total of 405 528 school-going adolescents (mean [SD] age, 14.2 [1.7] years; 196 147 [48.4%] males). The prevalence of overweight and obesity among adolescent students varied from 3.3% (95% CI, 2.6 to 4.1) in Cambodia to 64.0% (95% CI, 57.0 to 71.6) in Niue, and the prevalence of adolescent students consuming soft drinks 1 or more times per day varied from 3.3% (95% CI, 2.9 to 3.7) in Iceland to 79.6% (95% CI, 74.0 to 85.3) in Niue. There was a positive correlation between the prevalence of daily soft drink consumption and the prevalence of overweight and obesity (R, 0.44; P < .001). The pooled analysis using individual-level data also showed a statistically significant association between daily soft drink consumption and overweight and obesity (daily soft drink consumption vs nondaily soft drink consumption), with an odds ratio of 1.14 (95% CI, 1.08 to 1.21) among school-going adolescents.In this study of 107 countries and regions, the prevalence of daily consumption of soft drinks was associated with the prevalence of overweight and obesity among adolescent students. Our results, in conjunction with other evidence, suggest that reducing soft drink consumption should be a priority in combating adolescent overweight and obesity.
Insulin Fills by Medicare Enrollees and Out-of-Pocket Caps Under the Inflation Reduction Act
Authors: Rebecca Myerson, Dima M. Qato, Dana P. Goldman, John A. Romley
Journal: JAMA (2023)

This study uses data from IQVIA’s National Prescription Audit to assess the association of the Inflation Reduction Act’s cap on cost sharing with insulin fills by Medicare beneficiaries.
PSMA Uptake in a Subdural Hematoma
Authors: Tristan R. Lawson, Sophia R. O’Brien, Austin R. Pantel
Journal: Clinical Nuclear Medicine (2023)

Abstract An 81-year-old man with known metastatic prostate cancer with recent biochemical progression underwent a PSMA PET/CT ( 18 F-piflufolastat) for restaging. Review of the images demonstrated an acute or chronic left cerebral convexity subdural hematoma on CT with corresponding radiotracer activity throughout the collection on PET. Analysis of the patient’s prior imaging showed that this subdural hematoma had significantly increased in size when compared with a head CT obtained 2 months prior. The patient was referred to a nearby emergency department and underwent repeat imaging and subdural drain placement. Unfortunately, the patient died secondary to rapid reaccumulation of subdural blood products after intervention.
Primary Pancreatic Lymphoma Masquerading as Carcinoma on 18F-FDG PET/CT
Authors: Yun Chen, Shan Zheng, Zenan Wu, Yanmin Lin, Weibing Miao
Journal: Clinical Nuclear Medicine (2023)

Abstract A 76-year-old man with yellowish discoloration of sclera and skin for 2 months was referred to 18 F-FDG PET/CT for metabolic characterization of the mass in the pancreas. The images showed intense FDG uptake in the head of the pancreas, as well as a lymph nodal mass in the hepatic hilar region, which was consistent with pancreatic malignancy. Histopathologic findings showed characteristic findings of diffuse large B-cell lymphoma with no evidence of adenocarcinoma.
Error in Wording
Journal: JAMA Network Open (2023)

In the Original Investigation titled "Incarceration of Youths in an Adult Correctional Facility and Risk of Premature Death," 1 published July 5, 2023, there was an error in the Methods section; in the fourth sentence of the Statistical Analysis subsection, "combination" should be changed to "first" (the imputed values for the covariates represent the first of 5 imputed data sets).This article has been corrected.
Historical Reflection as the American Thoracic Society Moves to Combat Racism in Pulmonary and Critical Care Medicine
Authors: Sande O. Okelo, Christopher F. Chesley, Isaretta Riley, Alejandro A. Diaz, Karen Collishaw, Lynn M. Schnapp, Neeta Thakur
Journal: American Journal of Respiratory and Critical Care Medicine (2023)

"Historical Reflection as the American Thoracic Society Moves to Combat Racism in Pulmonary and Critical Care Medicine." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
Superoxide Dismutase‐Like Regulated Fe/Ppa@PDA/B for Synergistically Targeting Ferroptosis/Apoptosis to Enhance Anti‐Tumor Efficacy
Authors: Xin Ding, Zidong Wang, Qiying Yu, Nowicki Michał, Szewczyk Roman, Yi Liu, Na Peng
Journal: Advanced Healthcare Materials (2023)

The cell apoptosis pathway of sonodynamic therapy (SDT) is usually blocked, resulting in limited therapeutic efficacy, therefore, the development of new methods for sensitizing targeted ferroptosis and promoting apoptosis is of great significance to improve the anti-tumor efficacy of SDT. Herein, mesoporous Fe3 O4 nanoparticles (NPs) are synthesized for loading pyropheophorbide-a (ppa), surface-coated by polydopamine (PDA) and further anchored with tumor-targeting moieties of biotin to obtain Fe/ppa@PDA/B NPs. Fe/ppa@PDA/B displayes pH/ultrasound (US) responsive release properties, and magnetic resonance imaging (MRI) functions. Moreover, Fe3 O4 NPs of Fe/ppa@PDA/B as the Fe source for ferroptosis, enhances ferroptosis sensitivity by consuming glutathione (GSH) and producing hydroxyl radical (OH). The quinone groups of PDA layer on Fe/ppa@PDA/B own free electrons, which led to effective superoxide dismutase (SOD) action through superoxide anion (O2- ) disproportionation to hydrogen peroxide (H2 O2 ) and oxygen (O2 ), thus, overcame hypoxia of SDT and promoted ·OH generation by Fe ions under US trigger, synergistically improves ferroptosis and apoptosis to enhance the anti-tumor efficacy of SDT both in vitro and in vivo. The anti-tumor strategy of synergistic apoptosis and ferroptosis induce by GSH depletion and self-sufficient O2 regulated by SOD provides a new idea for enhancing SDT efficacy.
Poly(vinyl pyrrolidone) derivatives as PEG alternatives for stealth, non-toxic and less immunogenic siRNA-containing lipoplex delivery
Authors: Manon Berger, François Toussaint, Sanaa Ben Djemaa, Julie Laloy, Hélène Pendeville, Brigitte Evrard, Christine Jerôme, Anna Lechanteur, Denis Mottet, Antoine Debuigne, Géraldine Piel
Journal: Journal of Controlled Release (2023)
99mTc-MIBI SPECT/CT in a Case of Renal Oncocytosis
Authors: Qian Zhao, Aisheng Dong, Changjing Zuo, Bo Yang
Journal: Clinical Nuclear Medicine (2023)

Abstract Renal oncocytosis is a very rare oncologically indolent form of renal neoplasia characterized by diffuse involvement of renal parenchyma by numerous oncocytic nodules. We describe contrast-enhanced CT and 99m Tc-MIBI SPECT/CT findings in a patient with renal oncocytosis presenting with metachronous bilateral renal tumors. Contrast-enhanced CT showed numerous tumors ranging from several millimeters up to 3.9 cm in the left kidney. The tumors showed hypervascularity in the corticomedullary phase and washout in the excretory phase mimicking renal cell carcinoma. The larger tumors showed higher 99m Tc-MIBI uptake than the adjacent renal parenchyma, suggesting renal oncocytoma confirmed by biopsy.
Lung Nodule as Culprit Lesion Causing Recurrent Tumor-Induced Osteomalacia Revealed by 68Ga-DOTATATE PET/CT
Authors: Yuwei Zhang, Peipei Wang, Hongli Jing
Journal: Clinical Nuclear Medicine (2023)

Abstract Neoplasms that cause tumor-induced osteomalacia are very rarely located in the lung. A 27-year-old man underwent a surgery in the right femoral head to remove the tumor that induced osteomalacia 8 years ago with complete symptomatic relief. However, his bone pain occurred again recently, which lead to suspicion of a recurrent tumor-induced osteomalacia. 68 Ga-DOTATATE PET/CT images showed a pulmonary nodule with mildly increased uptake along with increased activity in the left foot. The pulmonary nodule was subsequently resected and was pathologically confirmed as a phosphaturic mesenchymal tumor. The symptoms were completely relieved postsurgery.
Notice of Retraction and Replacement. Goobie et al. Association of Particulate Matter Exposure With Lung Function and Mortality Among Patients With Fibrotic Interstitial Lung Disease. <i>JAMA Intern Med</i>. 2022;182(12):1248-1259
Authors: Gillian C. Goobie, S. Mehdi Nouraie
Journal: JAMA Internal Medicine (2023)

To the Editor On behalf of our coauthors, we write to explain errors in the article "Association of Particulate Matter Exposure With Lung Function and Mortality Among Patients With Fibrotic Interstitial Lung Disease" 1 that was published online first on
Vaccination After SARS-CoV-2 Infection and Post−COVID-19 Condition
Authors: Chengliang Yang, Linda Lapp, Scott J. Tebbutt
Journal: JAMA Internal Medicine (2023)

Vasiliki Tsampasian, MD, MSc; Hussein Elghazaly, MBBS; Rahul Chattopadhyay, MBBS, MSc; Maciej Debski, MD, PhD; Thin Kyi Phyu Naing, MBBS; Pankaj Garg, PhD; Allan Clark, PhD; Eleana Ntatsaki, MD(Res), MA; Vassilios S. Vassiliou, MBBS, PhD
Validation of a Proprietary Deterioration Index Model and Performance in Hospitalized Adults
Authors: Thomas F. Byrd, Bronwyn Southwell, Adarsh Ravishankar, Travis Tran, Abhinab Kc, Tom Phelan, Genevieve B. Melton-Meaux, Michael G. Usher, Daren Scheppmann, Sean Switzer, Gyorgy Simon, Christopher J. Tignanelli
Journal: JAMA Network Open (2023)

The Deterioration Index (DTI), used by hospitals for predicting patient deterioration, has not been extensively validated externally, raising concerns about performance and equitable predictions.To locally validate DTI performance and assess its potential for bias in predicting patient clinical deterioration.This retrospective prognostic study included 13 737 patients admitted to 8 heterogenous Midwestern US hospitals varying in size and type, including academic, community, urban, and rural hospitals. Patients were 18 years or older and admitted between January 1 and May 31, 2021.DTI predictions made every 15 minutes.Deterioration, defined as the occurrence of any of the following while hospitalized: mechanical ventilation, intensive care unit transfer, or death. Performance of the DTI was evaluated using area under the receiver operating characteristic curve (AUROC) and area under the precision recall curve (AUPRC). Bias measures were calculated across demographic subgroups.A total of 5 143 513 DTI predictions were made for 13 737 patients across 14 834 hospitalizations. Among 13 918 encounters, the mean (SD) age of patients was 60.3 (19.2) years; 7636 (54.9%) were female, 11 345 (81.5%) were White, and 12 392 (89.0%) were of other ethnicity than Hispanic or Latino. The prevalence of deterioration was 10.3% (n = 1436). The DTI produced AUROCs of 0.759 (95% CI, 0.756-0.762) at the observation level and 0.685 (95% CI, 0.671-0.700) at the encounter level. Corresponding AUPRCs were 0.039 (95% CI, 0.037-0.040) at the observation level and 0.248 (95% CI, 0.227-0.273) at the encounter level. Bias measures varied across demographic subgroups and were 14.0% worse for patients identifying as American Indian or Alaska Native and 19.0% worse for those who chose not to disclose their ethnicity.In this prognostic study, the DTI had modest ability to predict patient deterioration, with varying degrees of performance at the observation and encounter levels and across different demographic groups. Disparate performance across subgroups suggests the need for more transparency in model training data and reinforces the need to locally validate externally developed prediction models.
Population-Based Incidence of Influenza-Associated Serious Neuropsychiatric Events in Children and Adolescents
Authors: James W. Antoon, Derek J. Williams, Jean Bruce, Mert Sekmen, Yuwei Zhu, Kathryn M. Edwards, Carlos G. Grijalva
Journal: JAMA Pediatrics (2023)

This cohort study assesses the incidence of influenza-associated serious neuropsychiatric events among US children and adolescents.
Psychosocial Burdens Associated With Family Building Among Physicians and Medical Students
Authors: Morgan S. Levy, Amelia G. Kelly, Claudia Mueller, Alyssa D. Brown, Alberto J. Caban-Martinez, Vineet M. Arora, Arghavan Salles
Journal: JAMA Internal Medicine (2023)

This survey study uses responses from physicians and medical students to assess psychosocial burdens of family building in the physician workforce.
68Ga–Prostate-Specific Membrane Antigen PET/CT in Imaging of Hemangiopericytoma
Authors: Jolanta Kunikowska, Beata E. Chrapko
Journal: Clinical Nuclear Medicine (2023)

Hemangiopericytoma is a mesenchymal neoplasm that derives from pericytes surrounding the capillaries presenting overexpression of PSMA, which can be a source of pitfall in 68 Ga-PSMA-11 PET/CT. We reported 2 cases with recurrent hemangiopericytoma grade III with high expression of 68 Ga-PSMA-11 in PET/CT. Based on the performed examination, one of them received targeted α-therapy with the IV injection of 225 Ac-PSMA-617.
Primary Hepatocellular Carcinoma Revealed on 68Ga-DOTATATE in a Patient With Nasopharyngeal Carcinoma
Authors: Mengfang Qi, Yanlin Liu, Minggang Su, Rui Huang
Journal: Clinical Nuclear Medicine (2023)

Abstract A 56-year-old man underwent a prospective study (ChiCTR2300070081), which is a head-to-head comparison of 18 F-FDG and 68 Ga-DOTATATE PET/MR in EB-positive nonkeratinizing nasopharyngeal carcinoma after chemotherapy. Bilateral cervical abnormal lymph nodes were both detected by 18 F-FDG and 68 Ga-DOTATATE PET/MRI, whereas 2 hepatic lesions only were shown on 68 Ga-DOTATATE, which subsequent pathologically proved to be primary hepatocellular carcinoma.