tbuckley/cabot-search huggingface dataset:
Awake Prone Positioning in COVID-19: Signal or Noise?—Reply
Authors: Edward T. Qian, Cheryl L. Gatto, Todd W. Rice
Journal: JAMA Internal Medicine (2022)

Edward Tang Qian, MD; Cheryl L. Gatto, PhD; Olga Amusina, DNP; Mary Lynn Dear, PhD; William Hiser, BA; Reagan Buie, MHA; Sunil Kripalani, MD; Frank E. Harrell Jr, PhD; Robert E. Freundlich, MD, MS, MSCI; Yue Gao, MS; Wu Gong, MD, MS; Cassandra Hennessy, MS; Jillann Grooms, MSN; Megan Mattingly, MSN; Shashi K. Bellam, MD; Jessica Burke, MD; Arwa Zakaria, DO; Eduard E. Vasilevskis, MD; Frederic T. Billings IV, MD, MSc; Jill M. Pulley, MBA; Gordon R. Bernard, MD; Christopher J. Lindsell, PhD; Todd W. Rice, MD, MSc; Vanderbilt Learning Healthcare System Platform Investigators; Robert Dittus; Shon Dwyer; Paul Harris; Tina Hartert; Jim Hayman; Catherine Ivory; Kevin Johnson; Ruth Kleinpell; Lee Ann Liska; Patrick Luther; Jay Morrison; Thomas Nantais; Mariann Piano; Kris Rhem; Russell Rothman; Matt Semler; Robin Steaban; Philip Walker; Consuelo Wilkins; Adam Wright ; Autumn Zuckerman
Vitamin D as a chemopreventive agent in colorectal neoplasms. A systematic review and meta-analysis of randomized controlled trials
Authors: Georgia Emmanouilidou, Georgios Kalopitas, Dimitra Rafailia Bakaloudi, Evangelia Karanika, Eleni Theocharidou, Georgios Germanidis, Michail Chourdakis
Journal: Pharmacology & Therapeutics (2022)
Improving and Driving Efficiency in Your Endoscopy Unit in the 21st Century
Authors: Sumeet K Tewani, George C Tannous, Matthew W Stier, Erica Natal, Joseph Vicari
Journal: Clinical Gastroenterology and Hepatology (2022)

Operations management deals with processes. Processes are fundamental activities organizations use to complete work and attain goals. For organizations to operate efficiently, all employees must work together to complete the delivery of the service offered. Organizational efficiency is directly related to the successful implementation of its processes. When processes are effective, organizational efficiency follows. Organizational efficiency leads to delivery of services that are valued by patients and payors.
Healthy lifestyle and life expectancy at age 30 years in the Chinese population: an observational study
Authors: Qiufen Sun, Dongmei Yu, Junning Fan, Canqing Yu, Yu Guo, Pei Pei, Ling Yang, Yiping Chen, Huaidong Du, Xiaoming Yang, Sam Sansome, Yongming Wang, Wenhua Zhao, Junshi Chen, Zhengming Chen, Liyun Zhao, Jun Lv, Liming Li
Journal: The Lancet Public Health (2022)
Assessment of Calories Purchased After Calorie Labeling of Prepared Foods in a Large Supermarket Chain
Authors: Joshua Petimar, Anna H. Grummon, Fang Zhang, Steven L. Gortmaker, Alyssa J. Moran, Michele Polacsek, Eric B. Rimm, Christina A. Roberto, Anjali Rao, Lauren P. Cleveland, Denise Simon, Rebecca L. Franckle, Sue Till, Julie Greene, Jason P. Block
Journal: JAMA Internal Medicine (2022)

Calorie labels for prepared (ie, ready-to-eat) foods are required in large chain food establishments in the US. Large evaluations in restaurants suggest small declines in purchases of prepared foods after labeling, but to the authors' knowledge, no studies have examined how this policy influences supermarket purchases.
Behavioral strategies for periodontal health
Authors: Jean E. Suvan, Maja Sabalic, Mário R. Araújo, Christoph A. Ramseier
Journal: Periodontology 2000 (2022)

Abstract The impact of lifestyle factors has been increasingly studied and discussed in oral healthcare. Positive lifestyle factors are important in maintaining oral health or controlling disease, but they are not easy to adopt over the long term. Along with public health initiatives within communities and groups, there is a role for behavior change interventions delivered in dental practice settings to improve the periodontal health of individuals. Behavior management is now seen as a part of both prevention and therapy of periodontal diseases. This article summarizes the evidence on behavioral strategies for periodontal health to inform and assist oral healthcare professionals in implementing behavior change in their practice. In addition, strategies for education and training in communication and behavior change techniques are considered.
Balloon pulmonary angioplasty versus riociguat for the treatment of inoperable chronic thromboembolic pulmonary hypertension (RACE): a multicentre, phase 3, open-label, randomised controlled trial and ancillary follow-up study
Authors: Xavier Jaïs, Philippe Brenot, Hélène Bouvaist, Mitja Jevnikar, Matthieu Canuet, Céline Chabanne, Ari Chaouat, Vincent Cottin, Pascal De Groote, Nicolas Favrolt, Delphine Horeau-Langlard, Pascal Magro, Laurent Savale, Grégoire Prévot, Sébastien Renard, Olivier Sitbon, Florence Parent, Romain Trésorier, Cécile Tromeur, Céline Piedvache, Lamiae Grimaldi, Elie Fadel, David Montani, Marc Humbert, Gérald Simonneau
Journal: The Lancet Respiratory Medicine (2022)
Sustained-Release Ivabradine Hemisulfate in Patients With Systolic Heart Failure
Authors: Feiming Ye, Xiaofeng Wang, Shulin Wu, Shumei Ma, Yu Zhang, Gang Liu, Kunshen Liu, Zhiming Yang, Xiaohua Pang, Li Xue, Shijuan Lu, Ming Zhong, Jing Li, Hao Yu, Donghua Lou, Dongyang Cui, Xiaojie Xie, Jian'an Wang
Journal: Journal of the American College of Cardiology (2022)
Primary cilia regulate adaptive responses to fasting
Authors: Dong Joo Yang, Le Trung Tran, Seul Gi Yoon, Je Kyung Seong, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
Journal: Metabolism (2022)

Neuronal primary cilia are known to be a required organelle for energy balance and leptin action. However, whether primary cilia directly mediate adaptive responses during starvation is yet unknown. Therefore, we investigated the counterregulatory roles of primary cilia, and their related leptin action in energy-depleted condition.We generated leptin receptor (LepR) neuron-specific primary cilia knockout (Ift88 KOLepR) mice. Leptin-mediated electrophysiological properties of the neurons in fasting condition were assessed using patch-clamp technique. Adaptive responses and neuroendocrine reflexes were measured by monitoring counterregulatory hormones.In fasting state, the leptin-induced neuronal excitability and leptin homeostasis were impaired in Ift88 KOLepR. In addition, the Ift88 KOLepR exhibited aberrant fasting responses including lesser body weight loss, decreased energy expenditure, and lower heat generation compared to wild-type littermates. Furthermore, the primary cilia in LepR neurons are necessary for counterregulatory responses and leptin-mediated neuroendocrine adaptation to starvation.Our results demonstrated that the neuronal primary cilia are crucial neuronal components mediating the adaptive counterregulatory responses to starvation.
Synthetic Cannabinoids: A Pharmacological and Toxicological Overview
Authors: Rita Roque-Bravo, Rafaela Sofia Silva, Rui F. Malheiro, Helena Carmo, Félix Carvalho, Diana Dias da Silva, João Pedro Silva
Journal: The Annual Review of Pharmacology and Toxicology (2022)

Synthetic cannabinoids (SCs) are a chemically diverse group of new psychoactive substances (NPSs) that target the endocannabinoid system, triggering a plethora of actions (e.g., elevated mood sensation, relaxation, appetite stimulation) that resemble, but are more intense than, those induced by cannabis. Although some of these effects have been explored for therapeutic applications, anticipated stronger psychoactive effects than cannabis and reduced risk perception have increased the recreational use of SCs, which have dominated the NPS market in the United States and Europe over the past decade. However, rising SC-related intoxications and deaths represent a major public health concern and embody a major challenge for policy makers. Here, we review the pharmacology and toxicology of SCs. A thorough characterization of SCs' pharmacodynamics and toxicodynamics is important to better understand the main mechanisms underlying acute and chronic effects of SCs, interpret the clinical/pathological findings related to SC use, and improve SC risk awareness.
Periodontitis and implant complications in diabetes
Authors: Luigi Nibali, Nikolaos Gkranias, Giuseppe Mainas, Antonino Di Pino
Journal: Periodontology 2000 (2022)

Abstract Epidemiologic evidence indicates that periodontitis is more frequent in patients with uncontrolled diabetes mellitus than in healthy controls, suggesting that it could be considered the “sixth complication” of diabetes. Actually, diabetes mellitus and periodontitis are two extraordinarily prevalent chronic diseases that share a number of comorbidities all converging toward an increased risk of cardiovascular disease. Periodontal treatment has recently been shown to have the potential to improve the metabolic control of diabetes, although long‐term studies are lacking. Uncontrolled diabetes also seems to affect the response to periodontal treatment, as well as the risk to develop peri‐implant diseases. Mechanisms of associations between diabetes mellitus and periodontal disease include the release of advanced glycation end products as a result of hyperglycemia and a range of shared predisposing factors of genetic, microbial, and lifestyle nature. This review discusses the evidence for the risk of periodontal and peri‐implant disease in diabetic patients and the potential role of the dental professional in the diabetes‐periodontal interface.
First-line avelumab for patients with PD-L1-positive metastatic or locally advanced urothelial cancer who are unfit for cisplatin
Authors: R. Iacovelli, C. Ciccarese, M. Brunelli, N. Battelli, C. Buttigliero, C. Caserta, S. Buti, D. Santini, C. Carella, L. Galli, E. Verri, P. Ermacora, S. Merler, C. Masini, R. De Vivo, L. Milesi, F. Spina, M. Rizzo, I. Sperduti, G. Fornarini, G. Tortora
Journal: Annals of Oncology (2022)
Risk factors for periodontitis &amp; peri‐implantitis
Authors: Ivan Darby
Journal: Periodontology 2000 (2022)

Abstract Risk is part of all health professions and generally indicates the chance of getting some form of illness. For dental practitioners this includes periodontitis or peri‐implantitis, the focus of this issue. Many risk factors are involved in the development of disease and most likely interact or overlap. Most patients will probably have multiple risk factors, some of which will be the same for both periodontitis and peri‐implantitis. The most recent classification of periodontal disease recognises the importance of risk factors and contemporary dental practice requires that clinicians be aware of and manage them. Broadly speaking risk factors can be patient, environment or practitioner related. Patient risk factors would include socio‐economic status, smoking, substance use disorders, diabetes, diet and dietary supplements, mental health disorders, old age, poor home dental care or understanding of the need for good home care and use of medications. Environmental modification of the host response through gene function is an emerging risk factor. Lastly, practitioner‐related factors in implant dentistry are now known to affect risk. These would include the use of digital technology, but patient related factors such implant location and the body’s reaction to an implant itself add to the risk of developing disease. This edition of Periodontology provides an uptodate review of many of these risk factors and their impact summarising current knowledge.
Preventing Obesity—It Is Time for Multiple Policy Strategies
Authors: Marion Nestle
Journal: JAMA Internal Medicine (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Impact of the COVID-19 Pandemic on Cardiovascular Health in 2020
Authors: Gregory A. Roth, Muthiah Vaduganathan, George A. Mensah
Journal: Journal of the American College of Cardiology (2022)

The impact of COVID-19 on the burden of cardiovascular diseases (CVD) during the early pandemic remains unclear. COVID-19 has become one of the leading causes of global mortality, with a disproportionate impact on persons with CVD. Studies of health facility admissions for CVD found significant decreases during the pandemic. Studies of hospital mortality for CVD were more variable. Studies of population-level CVD mortality differed across countries, with most showing decreases, although some revealed increases in deaths. In some countries where large increases in CVD deaths were reported in vital registration systems, misclassification of COVID-19 as CVD may have occurred. Taken together, studies suggest heterogeneous effects of the COVID-19 pandemic on CVD without large increases in CVD mortality in 2020 for a number of countries. Clinical and population science research is needed to examine the ways in which the pandemic has affected CVD burden.
JAMA Internal Medicine
Authors: Thomas Easley, Brian Shields, Karen Adams-Taylor, Paul Gee, Monica Smith, Jeff Ery, J Bonistalli, Kathy Russell, Mirna Monal, Stacey Mchugh, Tim Melroy, Marketing Thornbury, Tricia Castellano, Anna Coordinator, Meghan Thue, Sade Deramus-Townsend, Thalia Recruitment, Samantha Bauer, Hank Eurich, Marsha Fogler, Rachel Sisholtz, Saskia Bolore, Gretchen Linder, Brian Mccartney, Christine Hearne, Natasha Staff, Henry Aguillon, David Baum, Ron Marketing, Rick Bell, Elizabeth Solaro, Sara Zimmerman, Geoff Rey, Lindsay Dawson, Ellen Gibson, Craig Mccaff Rey, Michael Mcgraw, Daniel Pickhardt, Romando Rossini, Sarah Subramanian, Stacy Tucker, Walsh Business, Analyst Sirisha, Alluri Staff, Millette Jackson-Bates, Tom Miller, Jacob Mishkin, Morgan Business, Karl Elvin, Nancy Essex, Jaye Mize, Sean O'donnell, Sue Managers, David Antos, Anthony Bautista, Chris Borden, Debbie Camp, Lydia Cruz, Scott Curl, Diane Darnell, Nanette Diaz, Jordynn Farrar, Allison Hughes, Colleen Kelly, John Lash, Chris Meyer, Annemarie Neff, J Neff, Sean Ohlson, Phil O'leary, Bill Pedone, Susan Price, Jaynam Shah, Erin Spencer, Denise Steinhauser, Joe Advertising, Production Services, Ahmed Avendano, Kim Boler, Rhonda Brown, Fin Carter, Michael Deegan, Euwanaha Joiner-Smith, Joshua Lane, Cindy Rendlen, John Rhead, Janis Trinchere, Annissa Zak, Circulation Services, Julie Burton, Ronna Hewitt, Mary Sieck, Geneine Someren, Jamaal Vargas, Content Systems, Mike Bujewski, Nathan Mitre, Digital Production, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Maleeka Holden, Teri Hutchison, Dan Knowles, Joshua Lampinen, Natalie Marsh, Patricia Panek, Marla Seidell, La Son Diggs-Sledge, Julian Graphics, Joe Amft, Jonathan Chala, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Maria Giannini, Sasha Grossman, Kate Lander, Judith Literskis, Teresa Omiotek, Michael Ryder, James Madara, Terri Carter, Fellows Mithi, Del Rosario, Vinay Guduguntla, Anand Habib, Audrey Han, Natalie Richmond, Eric Ward, Zachary Goldberger, Nora Goldschlager, San Francisco, Elsayed Soliman, Winston-Salem North, Fiona Clement, Kirsten Bibbins-Domingo, Rita Redberg, Deborah Grady, Michael Incze, Salt City, Tanner Caverly, Ann Arbor, Brandon Combs, Sanket Dhruva
Journal: JAMA Internal Medicine (2022)

Mission Statement: To promote the art and science of medicine and the betterment of public health by publishing manuscripts of interest and relevance to internists practicing as generalists or as medical subspecialists.
Preventing Obesity in Midlife Women: A Systematic Review for the Women's Preventive Services Initiative
Authors: Amy G. Cantor, Heidi D. Nelson, Miranda Pappas, Chandler Atchison
Journal: Annals of Internal Medicine (2022)

Despite high prevalence rates of obesity in the United States, no clinical guidelines exist for obesity prevention in midlife women who commonly experience weight gain.To evaluate evidence on the effectiveness and harms of behavioral interventions to reduce weight gain and improve health outcomes for women aged 40 to 60 years without obesity.English-language searches of Ovid MEDLINE, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews (inception to 26 October 2021); ClinicalTrials.gov (October 2021); and reference lists of studies and reviews.Randomized controlled trials (RCTs) enrolling predominantly midlife women comparing behavioral interventions to prevent weight gain with control groups and reporting health outcomes and potential harms.Dual extraction and quality assessment of individual studies.Seven RCTs in 12 publications (n = 51 638) were included. Four RCTs showed statistically significant favorable differences in weight change for counseling interventions versus control groups (mean difference of weight change, -0.87 to -2.5 kg), whereas 1 trial of counseling and 2 trials of exercise showed no differences; 1 of 2 RCTs reported improved quality-of-life measures. Interventions did not increase measures of depression or stress in 1 trial; self-reported falls (37% vs. 29%; P < 0.001) and injuries (19% vs. 14%; P = 0.03) were higher with exercise counseling in 1 trial.Trials were generally small, heterogeneous, and lacked data on harms, long-term health outcomes, and specific patient populations.Counseling interventions to prevent weight gain in women during midlife may result in modest differences in weight change without causing important harms. More research is needed to determine optimal content, frequency, length, and number of sessions required and should include additional patient populations.Health Resources and Services Administration.
mRNA COVID-19 vaccines were linked to myocarditis at 28 d (0.15 to 10 excess events/100 000 vaccinated persons)
Authors: James M. Brophy
Journal: Annals of Internal Medicine (2022)

ACP Journal ClubAugust 2022mRNA COVID-19 vaccines were linked to myocarditis at 28 d (0.15 to 10 excess events/100 000 vaccinated persons)James M. Brophy, MD, PhDJames M. Brophy, MD, PhDMcGill University, Montreal, Quebec, Canada (J.M.B.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/J22-0057 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationKarlstad Ø, Hovi P, Husby A, et al. SARS-CoV-2 vaccination and myocarditis in a Nordic cohort study of 23 million residents. JAMA Cardiol. 2022;7:600-12. https://pubmed.ncbi.nlm.nih.gov/35442390Clinical Impact RatingsGIM/FP/GP: Cardiology: Infectious Disease: References1. Smith Jervelund S, De Montgomery CJ. Nordic registry data: value, validity and future [Editorial]. Scand J Public Health. 2020;48:1-4. [PMID: 31985364] Google Scholar2. Elflein J. Number of coronavirus disease 2019 (COVID-19) deaths in the U.S. as of June 2, 2022, by age. Statista. Published 2 Jun 2022. Accessed at www.statista.com/statistics/1191568/reported-deaths-from-covid-by-age-us/ on 13 Jun 2022. Google Scholar3. Mevorach D, Anis E, Cedar N, et al. Myocarditis after BNT162b2 mRNA vaccine against Covid-19 in Israel. N Engl J Med. 2021;385:2140-9. [PMID: 34614328] Google Scholar Author, Article, and Disclosure InformationAffiliations: McGill University, Montreal, Quebec, Canada (J.M.B.)Disclosures: The commentator has reported no disclosures of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=J22-0057.This article was published at Annals.org on 2 August 2022.ACP Journal Club is editorially independent from Annals of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics August 2022Volume 175, Issue 8Page: JC94KeywordsAdolescentsAge groupsCOVID-19Cohort studiesInformation storage and retrievalInpatientsMyocarditisRisk managementVaccines ePublished: 2 August 2022 Issue Published: August 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
In older adults, iron dextran and ferumoxytol each had higher anaphylaxis risk at ≤1 d than iron sucrose
Authors: Bethany Samuelson Bannow
Journal: Annals of Internal Medicine (2022)

Dave CV, Brittenham GM, Carson JL, et al. Risks for anaphylaxis with intravenous iron formulations: a retrospective cohort study. Ann Intern Med. 2022;175:656-64. 35344378.
Recommendations for use of ezetimibe and/or PCSK9 inhibitors in patients with elevated LDL-C
Authors: Michelle D. Kelsey, L. Kristin Newby
Journal: Annals of Internal Medicine (2022)

Source Citation Hao Q, Aertgeerts B, Guyatt G, et al. PCSK9 inhibitors and ezetimibe for the reduction of cardiovascular events: a clinical practice guideline with risk-stratified recommendations. BMJ. 2022;377:e069066. 35508320
Preventing Obesity in Midlife Women: A Recommendation From the Women's Preventive Services Initiative
Authors: David Chelmow, Kimberly D. Gregory, Catherine Witkop, Susan Hoffstetter, Linda Humphrey, Carla Picardo, James J. Stevermer, Amy G. Cantor, Heidi D. Nelson, Sarah Son, Jeanne A. Conry, Francisco Garcia, Susan M. Kendig, Nancy O’Reilly, Amir Qaseem, Diana Ramos, Alina Salganicoff, Julie K. Wood, Christopher Zahn, Susan Hoffstetter, Linda Humphrey, Carla Picardo, James J. Stevermer, Catherine Witkop, David Chelmow, Jeanne A. Conry, Kimberly D. Gregory, Amy Cantor, Francisco Garcia, Susan M. Kendig, Heidi D. Nelson, Amir Qaseem, Diana Ramos, Alina Salganicoff, Julie K. Wood, Pelin Batur, Ana Sanchez-Birkhead, Gale Burstein, Michelle Collins, Teresa A. Hubka, Erin Mackay, Andria Cornell Mann, Alayne D. Markland, Dorianne Mason, Edith P. Mitchell, Nazanin E. Silver, Annamarie Streilein, Nancy O’Reilly, Sarah Son, Christopher Zahn, Bushra Idlibi, Michelle Jones
Journal: Annals of Internal Medicine (2022)

Description: The Women's Preventive Services Initiative (WPSI), a national coalition of women's health professional organizations and patient advocacy representatives, developed a recommendation for counseling midlife women aged 40 to 60 years with normal or overweight body mass index (BMI; 18.5 to 29.9 kg/m2) to maintain weight or limit weight gain to prevent obesity with the long-term goals of optimizing health, function, and well-being. This recommendation is intended to guide clinical practice and coverage of clinical preventive health services for the Health Resources and Services Administration and other stakeholders. Clinicians providing preventive health care to women in primary care settings are the target audience for this recommendation. Methods: The WPSI developed this recommendation after evaluating results of a systematic review of the effectiveness and harms of interventions to prevent weight gain and obesity in women aged 40 to 60 years without obesity. Seven randomized clinical trials including 51 638 participants and using various counseling and behavioral interventions were included. Trials indicated favorable weight changes with interventions that were statistically significantly different from control groups in 4 of 5 trials of counseling, but not in 2 trials of exercise. Few harms were reported. Recommendation: The WPSI recommends counseling midlife women aged 40 to 60 years with normal or overweight BMI (18.5 to 29.9 kg/m2) to maintain weight or limit weight gain to prevent obesity. Counseling may include individualized discussion of healthy eating and physical activity.