tbuckley/cabot-search huggingface dataset:
Environment and Health - Bridging South, North, East and West. Basel, Switzerland 19-23 August 2013
Journal: Environmental Health Perspectives (2013)

EHP is pleased to present the abstracts from the 2013 conference Environment and Health-Bridging South, North, East and West, held 19-23 August 2013 in Basel, Switzerland, and hosted by the Swiss Tropical and Public Health Institute. The conference was a joint meeting of the International Society for Environmental Epidemiology (ISEE), the International Society of Exposure Science (ISES), and the International Society of Indoor Air Quality and Climate (ISIAQ). More than 1,700 participants from all continents and over 70 countries attended. The abstracts are searchable by abstract number, author name, and any word that appears anywhere in the abstract. Use the Filtered Search option to narrow search results by author-assigned keyword. Suggested citation: Abstracts of the 2013 Conference of the International Society of Environmental Epidemiology (ISEE), the International Society of Exposure Science (ISES), and the International Society of Indoor Air Quality and Climate (ISIAQ), August 19-23, 2013, Basel, Switzerland. 2013. Environ Health Perspect. Read how the organizers reduced the environmental footprint of the conference in "The Vision of a Green(er) Scientific Conference," an editorial in the August issue of EHP by Nino Künzli and Martin Röösli, conference chairs, and Martina S. Ragettli, chair of the local organizing committee "green club." For more information on the conference, be sure to check out the press release and photos from the Swiss Tropical and Public Health Institute.
Social Factors in Medical Progress.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Appendectomy in Hemophilia With the Use of Cryoprecipitated Human Factor VIII to Control Bleeding
Authors: Joel M. Schwartz
Journal: JAMA (1966)

Appendectomy was safely performed in a 9-year-old boy with classic hemophilia, and hemostasis was achieved by the use of cryoprecipitated human antihemophilic globulin therapy begun preoperatively and continued for 17 days. Except for urticaria, the use of cryoprecipitated factor VIII was entirely free of side effects. Cryoprecipitated factor VIII is unique among all factor VIII concentrates prepared heretofore in that it is a by-product of plasma fractionation. It may be simply and economically prepared in any blood bank geared to plasma fractionation procedures and may be stored for months without loss of potency. As such cryoprecipitated factor VIII is soon expected to become generally available. The broad clinical use of a potent human factor VIII concentrate holds promise of further reducing the risk and morbidity of bleeding in hemophilia and of permitting safe elective as well as life-saving surgery.
Pediatric Nursing. A Textbook for Nurses.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diabetics' deaths: insulin pump connection?
Authors: Catherine Macek
Journal: JAMA (1982)

The Centers for Disease Control (CDC) in Atlanta is investigating the deaths of 11 diabetic patients who were using continuous subcutaneous insulin infusion (CSII) pumps when they died. The open-loop pumps, which are used in conjunction with external home blood glucose monitors, are about the size of large paging units and inject insulin into the abdomen at a constant low rate with larger boluses injected before meals. The CDC estimates that about 4,000 pumps currently are in use in the United States, where they have been commercially available for about a year. "We're now trying to determine whether what we have here is the tip of the iceberg or the whole iceberg," says Steven Teutsch, MD, chief of operational research, Diabetes Control Activity, Center for Prevention Services at the CDC. Teutsch is preparing a short questionnaire to be sent to diabetologists, endocrinologists, and other physicians involved in pump therapy to
Toposcopic catheter traverses narrow vessels
Authors: James Doherty
Journal: JAMA (1984)

A type of miniature catheter, capable of conveying therapy directly to brain tumors, can pass through narrow, tortuous vessels inaccessible to conventional catheters without damaging the endothelium. The toposcopic—or "topo"—catheter, a flexible thin-walled polyurethane tube measuring 1 mm in diameter, can travel through vessels in which other narrow catheters would either buckle because they are too flexible, or get caught in turns because they are too firm. The difference is in the toposcopic catheter's way of advancing. Instead of being pushed from behind or pulled by the action of blood flow, the topo everts from the distal end of a conventional catheter that has been advanced as far as it can go. After each portion of the topo emerges, it remains motionless where it has been placed, like a miniature tank tread, while the continuing eversion lays down additional portions further on in the vessel (Figure). The tube thus advances
Prediction of minimal erythema dose with a reflectance melanin meter
Authors: D.L. DAMIAN, G.M. HALLIDAY, R.StC. BARNETSON
Journal: British Journal of Dermatology (1997)

The relationship between skin pigmentation and sensitivity to ultraviolet (UV) radiation‐induced erythema was investigated in 60 healthy subjects of sun‐reactive skin types I‐V. Using a portable reflectance spectrometer, skin pigmentation was measured as the melanin index (MI) in all subjects. A solar‐simulated array of filtered UVA and UVB‐emitting fluorescent lamps was then used to determine the UVB minimal erythema dose (MED) of each subject. MI readings and MED testing were both performed on the subjects mid to upper backs. Using this technique, we found a close correlation between MI and MED. Comparison of the mean MI or MED of subjects with different skin types revealed progressive differences in MI and MED between all five skin types. Erythema doseresponse curves, which provide further information about UV sensitivity, were also calculated for 43 subjects. A significant negative correlation was found between the gradients of these curves and both MI and MED. indicating that paler subjects respond more strongly to increments of UV above the MED than subjects with greater pigmentation. Our results indicate that although traditional, subjective means of predicting UV sensitivity to erythema are not without some value. MED correlates particularly strongly with objective measures of skin pigmentation. We therefore conclude that the reflectance spectrometer can rapidly and accurately predict UVB sensitivity, and should prove clinically useful for planning and optimizing UVB phototherapy.
Physician to the World: The Life of General William C. Gorgas
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Essentials of Occupational Diseases
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights of This Issue
Journal: Clinical Cancer Research (2011)

Organic anion transporting polypeptides (OATPs) are broadspecificity transmembrane uptake transporters.Using recently generated Oatp1a/1b cluster knockout mice, Van de Steeg and colleagues studied the role of Oatp1a/1b transporters in drug disposition.They found that Oatp1a/1b transporters play an important role in the in vivo pharmacokinetics of the hydrophobic anticancer drug paclitaxel, mainly by mediating its hepatic uptake.The impact of Oatp1a/1b transporters on the disposition of paclitaxel was unexpected as this drug was thought to mainly pass membranes by passive diffusion.These findings suggest that alterations in tumor or hepatic OATP activity might affect the therapeutic efficacy of paclitaxel.
Preliminary Communication
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights from Recent Cancer Literature
Journal: Cancer Research (2016)

PKA, Mesenchymal-to-Epithelial Transition, and ChemosensitivityBreast cancer tumor-initiating cells (TIC) have undergone an epithelial-to-mesenchymal transition and display resistance to chemotherapeutics.Pattabiraman and colleagues hypothesized that inducing a mesenchymal-to-epithelial transition might increase the sensitivity to chemotherapeutics.They screened TIC cultures for compounds that could activate an epithelial reporter.Two compounds increased cAMP levels, leading to activation of PKA, phosphorylation and activation of the histone (H3K9) demethylase PHF2, and derepression of epithelial cell-determining genes.Activation of this signaling cascade resulted in cells with epithelial characteristics and increased sensitivity to chemotherapeutics.Importantly, cultured TICs expressing an inducible form of PKA (PRKACA) formed metastatic tumors when implanted ortotopically into mice.Induction of PKA led to differentiation, reduced metastases, and reduced tumor burden after serial transplantation.This study suggests that drugs that decrease the epigenetic repression of an epithelial cell gene program can chemosensitize breast TICs.(Image courtesy of Wikimedia Commons.)
Correspondence re: C. Ford, <b> <i>et al</i> </b>. Mouse Mammary Tumor Virus-Like Gene Sequences in Breast Tumors of Australian and Vietnamese Women. Clin. Cancer Res., <b> <i>9:</i> </b> 1118–1120, 2003.
Authors: Caroline Ford, Margaret Faedo, Warick Delprado, William Rawlinson
Journal: Clinical Cancer Research (2004)

Since the publication of our article, “Mouse Mammary Tumor Virus-Like Gene Sequences in Breast Tumors of Australian and Vietnamese Women (Clin. Cancer Res., 9: 1118–1120, 2003), additional information has come to our attention. In our article, we reported a strong association between mouse mammary tumor virus (MMTV)-like gene sequences and breast tumors in the Australian population. Nineteen of 45 (42%) breast tumors tested were positive for MMTV-like sequences, and 2 of 111 (1.8%) normal breast tissues tested were also positive. We have followed up the 2 patients with MMTV-positive normal breast tissue and have discovered that 1 patient had a breast tumor in her contralateral breast before the removal of normal breast tissue tested in our study and that the second patient had a breast tumor in the ipsilateral breast subsequent to the removal of normal breast tissue tested in our study. We feel that this information should be conveyed to the readership of Clinical Cancer Research because it strengthens the implications of the study and further links these MMTV-like gene sequences to breast cancer.
Milwaukee Deaths Reignite Critical Issues in Cervical Cancer Screening
Authors: Rebecca Voelker
Journal: JAMA (1995)

GHOSTS FROM the pre—CLIA 88 era have come back to haunt technologists, physicians, and patients who rely on the sensitivity of the Papanicolaou (Pap) test for detecting cervical cancer. Last month's news reports that a cytology laboratory was charged in Milwaukee, Wis, with reckless homicide in connection with misread Pap smears has left the cytopathology community with a disturbing sense of déjà vu. "This [Milwaukee] case is similar to several other stories that first started to appear in 1987," explains Stanley L. Inhorn, MD, medical director of the Wisconsin State Laboratory of Hygiene and professor of pathology and laboratory medicine at the University of Wisconsin Medical School in Madison. "What they focus on is not that people missed the [diagnosis], but that the laboratory practice was one in which cytotechnologists were being encouraged, if not coerced, into reading large numbers of Paps, quotas were being set, and they were paying
The Nervous Affections of the Heart, Being the Morison Lectures Delivered Before the Royal College of Physicians of Edinburgh in 1902 and' 1903.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights from Recent Cancer Literature
Journal: Cancer Research (2017)

Rational Targets for Intracranial Rhabdoid TumorsAtypical teratoid rhabdoid tumors (ATRT), a frequently lethal intracranial tumor of infancy and early childhood, is defined by loss of SMARCB1 expression.Torchia and colleagues integrated genomewide DNA methylation and gene expression profiling across 191 primary ATRTs, identifying distinct subgroups termed 1, 2A, and 2B.ATAC-seq showed that group 1 tumors had relatively closed chromatin, while group 2A tumors were more open.ATAC-seq, H3K27ac Chip-seq, and chromatin conformation analyses identified an enhancer element 50-kb upstream of PDGFRB, driving its expression.This result was validated by showing that group 2, but not group 1, cell lines were highly sensitive to clinical PDGFR inhibitors.Thus, epigenetic mapping of ATRTs identified clinically relevant targets for this highly lethal malignancy.(Image courtesy of Wikimedia Commons.)
Ehlers-Danlos Syndrome and "Congenital" Arteriovenous Fistulae
Authors: Henry T. Lynch
Journal: JAMA (1965)

THE EHLERS-DANLOS syndrome (E-D) is a hereditary disorder of connective tissue wherein the pathogenesis is not clear. The phenotypic expression is exceedingly variable, such that minimally affected individuals may pass as "normal." Because of this, McKusick<sup>1</sup>speculates that E-D may actually be the most common of the heritable connective-tissue disorders. However, in the face of this, many aspects of this syndrome, including cardiovascular and systemic effects, remain to be explained. The purpose of this report is to present a family study of E-D wherein the proband was severely affected and died from rupture of an aneurysm of the thoracic aorta. At autopsy, he was found to have a fistula between the abdominal aorta and the inferior vena cava, as well as between the left common iliac artery and vein. So far as we can determine, this is the first report of E-D showing such fistulae. <h3>Report of a Case</h3>
DIAGNOSIS OF HYPERTHYROIDISM
Authors: JOHN MILLS
Journal: Annals of Internal Medicine (1968)

Letters and Comments1 May 1968DIAGNOSIS OF HYPERTHYROIDISMJOHN MILLS, M.D.JOHN MILLS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1135 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Although I am far from being an expert in the field, I must disagree with one of the conclusions in the article by Strott and Nugent, "Laboratory Tests in the Diagnosis of Hyperparathyroidism in Hypercalcemic Patients." In their discussion of these tests, they point out that none of them gave abnormal results in as many as 82% of the patients with primary hyperparathyroidism and that there was a high prevalence of false positives. Examining the data presented in Table 5 concerning the rapid calcium infusion test developed by Goldsmith (J. Urol. 89: 487, 1963;Arch. Intern. Med....References1. HALDENEISENBERGGORDAN AEG: Parathyroid hormone and phosphate homeostasis in man. Acta. Endocr. (Kobenhavn) 46: 285, 1964. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: NIAID NIH USPHS 5801 Wilson Lane Bethesda, Md. 20034 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1135-1137KeywordsCalciumHyperparathyroidismHyperthyroidismLaboratory tests Issue Published: 1 May 1968 PDF DownloadLoading ...
Highlights from Recent Cancer Literature
Journal: Cancer Research (2016)

Exploiting the Apoptosis Machinery for CLL TherapyConstitutive expression of the antiapoptotic protein BCL2 renders chronic lymphocytic leukemia (CLL) resistant to cell death, leading to a buildup of clonal lymphocytes.New BH3 mimetic drugs mimic the activity of physiologic BCL2 antagonists to activate apoptosis.Roberts and colleagues performed a phase 1 study of venetoclax, a selective BCL2 inhibitor, in patients with relapsed and heavily pretreated CLL.Over a range of doses, this approach induced an overall response rate (ORR) of 79% (n ¼ 116 patients) with a 2-year overall survival of 84%.Remarkably, patients with "deletion 17p CLL" and TP53 loss showed an ORR of 71%.Tumor lysis syndrome was observed in patients with substantial disease burden treated at higher doses, but a maximum tolerated dose represents one mechanism of tumor escape to be further characterized in future studies.(Image courtesy of Wikimedia Commons.