Patient-Level Pooled Analysis of Ultrasound Renal Denervation in the Sham-Controlled RADIANCE II, RADIANCE-HTN SOLO, and RADIANCE-HTN TRIO Trials
Authors: Ajay J. Kirtane, Andrew S. P. Sharp, Felix Mahfoud, Naomi D. L. Fisher, Roland E. Schmieder, Joost Daemen, Melvin D. Lobo, Philipp Lurz, Jan Basile, Michael J. Bloch, Michael A. Weber, Manish Saxena, Yale Wang, Kintur Sanghvi, J. Stephen Jenkins, Chandan Devireddy, Florian Rader, Philippe Gosse, Marc Sapoval, Neil C. Barman, Lisa Claude, Dimitri Augustin, Lisa Thackeray, Christopher M. Mullin, Michel Azizi, Candace K. McClure, Glenn Chertow, Venita Chandra, Harold Dauerman, Thomas Kahan, Steven Ullery, Nirat Beohar, Ozgen Dogan, Michelle Mokrzycki, Scott Mullaney, Bjorn Redfors, Huseng Vefali, J. Dawn Abbott, Andreas Loening, Ron Zagoria, Nedaa Skeik, Richard Bae, Amy McMeans, JoAnne Goldman, Rose Peterson, Desmond Jay, Robert Schwartz, John Reilly, Micheal Cash, Isabelle Tutor, Michael Harrison, Shannon Williams Williams, Maria Jarvis, Angel Penning, Janice Lea, Amanda Fiebach, Claudia Merlin, Bryan Wells, Suhail Dohad, Anne Tran, Kirin Bhatia, Hyun-Min Kim, Mohammad Rashid, Ronald Victor, Piotr Sobieszczyk, Ian Halliday, Tay Munson, Laura Mauri, Alex Smith, Laura Aseltine, Jonathan Williams, Jason Lindsey, Steven Laster, Mathew Bunte, Anthony Hart, Dana King, Jamie Hall, Josh Costello, Courtney Krathen, Luot Lewis, Andrew McElvarr, Ashley Willitts, Thomas Todoran, Eric Powers, Casey Palmer, Emily Hodskins, Vijay Paladugu, Anna Tecklenburg, John Schindler, John Pacella, Matthew Muldoon, MaryJo Albright, Tracy Nicholson, John Flack, Youseff Chami, Abdul Moiz Hafiz, Emily Starkey, Kristal Adams, Nelson Bernardo, Judith Veis, Hayder Hashim, Suman Singh, Donna Whitman, Rick Stouffer, Alan Hinderliter, Meghan Allen, Tatum Scholl, Eric Pauley, Tyrone Wade, Pete Fong, Chery Laffer, James Gainer, Mark Robbins, Sherron Crook, Ellen Hatchcock, Sarita Maddel, Debbie Cohen, Jay Giri, Taisei Kobayashi, Robin Neubauer, Suveeksha Naidu, Thu Vo, Jai Radhakrishnan, Candido Batres, Suzanne Edwards, Matheen Khuddus, Suzanne Zentko, Abby Touchton, Marti Roberson, James O'Meara, Ilie Barb, Abby Foster, Alice Boyette, Abhilash Akinapelli, Lisa English, Bridget Neumann, Chanwit Roongsritong, Priscilla Nelson, Farrel Mendelsohn, Hutton Brantley, Thomas Cawthon, Susan DeRamus, Wesley Wade, Robert Fishman, Edward Tuohy, Jessica LeBlanc, Tina McCurry, Amar Krishnaswamy, Luke Laffin, Christopher Bajzer, Marilyn Boros, Monica Branche, Josephine Abraham, Anu Abraham,  Inge Stijleman, Iran Lavasani, Hailey Neilson, Theophilus Owan, David Hsi, Scott Martin, Edward Portnay, Maryanne Ducey, Maryann Fiebach, Suzanne Rose, Elizabeth DelMasro, Carolina Garavito, Todd Adams, Andrew Teklinski, Adam Leech, Patrick Drilling, Lynda Tulik, Keith Benzuly, James Paparello, Dan Fintel, Haydee Ramirez, Lauren Kats, Paul Huang, Santanu Biswas, Serena Risher, Kristina Pratt, Uzoma Ibebuogu, Karen Johnson, William Cushman, Lisa Jones, Leigh Jackson, David Landers, Tilak Pasala, Thomas Salazer, Peter Canino, Patricia Arakelian, Yi-Ming Yang, Asma Khaliq, Mitchell Weinberg, Yihenew Abetu, Alana Gulliver, Joseph Garasic, Doug Drachman, Randy Zusman, Keneth Rosenfield, Danny Do, Atul Chugh, Barry Bertolet, Brian Go, Raghava Gallapudi, Joel Cohn, Kevin Rogers, Sripal Bangalore, Stephan Williams, Stanley Cabos, Carolina Rodriguez Alvarez, David Calhoun, Thomas McElderry, William Maddox, Suzanne Oparil, Sheila Kinder, Jessie Goldman, Gary Ledley, Nancy Katof, Sandeep Aggarwal, Sriivasa Potluri, Scott Biedermann, Jacquelyn Ward, Megan White, David Zidar, Mehdi Shishehbor, Barry Effron, Marco Costa, Terence Semenec, Pei-Hsiu Huang, Powell Jose, Micheal Jones, Anthony Mathur, Ajay Jain, Armida Balawon, Oliver Zongo, Christine Topham, Richard Anderson, Elizabeth Thompson, Nikki Spiro, Elizabeth Hodges, Jaqueine Holder, Richard J. D'Souza, Sarah Statton, Lindsay Wilkes, Anil Joseph, Timothy Ellam, Alan Bagnall, Ralph Jackson, Victoria Bridgett, Peter Wilson, Neelanjan Das, Timothy Doulton, David Loader, Gemma Hector, Terry Levy, Clare Bent, Vivek Kodoth, Stephanie Horler, Sara Nix, David Beckett, Nicki Lakeman, Sarah Kennard, Amit Patel, Nicholas Robinson, Faris Al-Janabi, Jeremy Sayer, Sudha Ganesh Iyer, Emily Redman, Jonaifah Ramirez, Annaliza Sevillano, Madelaine Ocampo, Sadat Ali Edroos, Sandosh Padmanabhan, Robert Gerber, Mohamad Faris, Andrew John Marshall, Janet Sinclair, Hayley Pepper, Cristina Elorz, Justin David, Neil Chapman, Paula Burak, Paula Carvelli, Matthew Shun Shin, James Howard, Sachin Jadhav, Jane Quinn, Faisal Sharif, Aishah Alhmoudi, Mattia Lunardi, Eileen Coen, Nicola Glynn, Michael Böhm, Lucas Lauder, Saarraaken Kulenthiran, Christina Koch, Angelika Wachter, Sebastian Ewen, Jelena Lucic, Axel Schmid, Dennis Kannenkeril, Christian Ott, Michael Uder, Ulrike Heinritz, Kerstin Fröhlich-Endres, Karl -Philipp Rommel, Karl  Fengler, Robert Höllriegel, Martin Petzold, Margit Büttner, Kai Trautmann, Joachim Weil, Tolga Agdirlioglu, Tanja Köllner, Jeannine Stephan, Lukas Hafer, Nikolaos Dagkonakis, Frank Hamann, Peter Reimer, Martin Hausberg, Ute Ettl, Ulrike Petzsche, Ralf Hinrichs, Isabella Di Ponio-Voit, Matthias Lutz, Lars Christian Rump, Johannes Stegbauer, Lars Schimmöller, Sebastian Potthoff, Claudia Schmid, Sylvia Roeder, Patric Kröpil, Sabine Genth-Zotz, Denise Kämpfner, Armin Grawe, Johannes Höhne, Bärbel Kaesberger, Constantin von zur Mühlen, Dennis Wolf, Markus Welzel, Gudrun Heinrichs, Barbara Trabitzsch, Antoine Cremer, Panteleimon Papadopoulos, Julie Gaudissard, Florent Maire, Hervé Trillaud, Marine Livrozet, Asma Regrag, Valerie Paquet, Erika Cornu, David Fouassier, Aurélien Lorthioir, Pascal Delsart, Justin Hennicaux, Benjamin Longere, Coralie Bailly-Sommeville, Fabien Bertrand, Guillaume Ledieu, François Pontana, Atul Pathak, Benjamin Honton, Marianne Cottin, Frédéric Petit, Pierr Lantelme, Constance Berge, Pierre-Yves Courand, Fatou Langevin, Melvin Lafeber, Victor Zeijen, Arno Ruiter, Elisabeth Huijskens, Lida Feyz, Jan van Ramshorst, Peter Blankestijn, Michiel Voskuil, Zwaantina Rittersma, Helma Dolmans, A.A. Kroon, W.H. van Zwam, Jeannique Vranken, Claudia de Haan, Panagiotis Xaplanteris, Rachid Briki, Quentin de Hemptinne, Severine Pascal, Katty Renard, Pascal Lefebvre, Bert Ferdinande, Alexandre Persu, Jean Renkin, Frédéric Maes, Christophe Beauloye, Jean-Philippe Lengelé, Dominique Huyberechts, Anne Bouvier, Juan F. Iglesias, Georg Ehret, Laetitia Gallego, Kevin Dobretz, Sylviane Bottone, Adam Witkowski, Andrzej Januszewicz, Jacek Kądziela Kądziela, Aleksander Prejbisj, Dagmara Hering, Dariusz Ciecwierz, Milosz J. Jaguszewski, Radoslaw Owczuk
Journal: JAMA Cardiology (2023)

Ultrasound renal denervation (uRDN) was shown to lower blood pressure (BP) in patients with uncontrolled hypertension (HTN). Establishing the magnitude and consistency of the uRDN effect across the HTN spectrum is clinically important.