tbuckley/cabot-search huggingface dataset:
Long‐term exposure from perinatal life to food‐grade TiO<sub>2</sub> alters intestinal homeostasis and predisposes to food allergy in young mice
Authors: Mohammad Issa, Chloé Michaudel, Marine Guinot, Marta Grauso‐Culetto, Blanche Guillon, Jérôme Lecardonnel, Luc Jouneau, Céline Chapuis, Hervé Bernard, Stephane Hazebrouck, Florence Castelli, François Fenaille, Eric Gaultier, Gilles Rivière, Eric Houdeau, Karine Adel‐Patient
Journal: Allergy (2023)

Abstract Background Food allergy (FA) is an inappropriate immunological response to food proteins resulting from an impaired induction of oral tolerance. Various early environmental factors can affect the establishment of intestinal homeostasis, predisposing to FA in early life. In this context, we aimed to assess the effect of chronic perinatal exposure to food‐grade titanium dioxide ( fg ‐TiO 2 ), a common food additive. Methods Dams were fed a control versus fg ‐TiO 2 ‐enriched diet from preconception to weaning, and their progeny received the same diet at weaning. A comprehensive analysis of baseline intestinal and systemic homeostasis was performed in offspring 1 week after weaning by assessing gut barrier maturation and microbiota composition, and local and systemic immune system and metabolome. The effect of fg ‐TiO 2 on the susceptibility of progeny to develop oral tolerance versus FA to cow's milk proteins (CMP) was performed starting at the same baseline time‐point, using established models. Sensitization to CMP was investigated by measuring β‐lactoglobulin and casein‐specific IgG1 and IgE antibodies, and elicitation of the allergic reaction by measuring mouse mast cell protease (mMCP1) in plasma collected after an oral food challenge. Results Perinatal exposure to fg ‐TiO 2 at realistic human doses led to an increased propensity to develop FA and an impaired induction of oral tolerance only in young males, which could be related to global baseline alterations in intestinal barrier, gut microbiota composition, local and systemic immunity, and metabolism. Conclusions Long‐term perinatal exposure to fg ‐TiO 2 alters intestinal homeostasis establishment and predisposes to food allergy, with a clear gender effect.
Hypoxia as a potential inducer of immune tolerance, tumor plasticity and a driver of tumor mutational burden: Impact on cancer immunotherapy
Authors: Raefa Abou Khouzam, Bassam Janji, Jerome Thiery, Rania Faouzi Zaarour, Ali N. Chamseddine, Hemma Mayr, Pierre Savagner, Claudine Kieda, Sophie Gad, Stéphanie Buart, Jean–Marie Lehn, Perparim Limani, Salem Chouaib
Journal: Seminars in Cancer Biology (2023)
Letter to the Editor regarding ‘Correspondence to: Amivantamab plus chemotherapy with and without lazertinib in EGFR-mutant advanced NSCLC after disease progression on osimertinib: primary results from the phase III MARIPOSA-2 study’ by Moik F, Riedl JM, and Ay C
Authors: A. Passaro, J. Wang, S. Shah, J.M. Bauml, R.G. Campelo, B.C. Cho
Journal: Annals of Oncology (2023)
Local delivery of EGFR+NSCs-derived exosomes promotes neural regeneration post spinal cord injury via miR-34a-5p/HDAC6 pathway
Authors: Tian Qin, Chengjun Li, Yan Xu, Yiming Qin, Yuxin Jin, Rundong He, Zixiang Luo, Jinyun Zhao, Chunyue Duan, Hongbin Lu, Yong Cao, Jianzhong Hu
Journal: Bioactive Materials (2023)

Spinal cord injury (SCI) causes severe axon damage, usually leading to permanent paraparesis, which still lacks effective regenerative therapy. Recent studies have suggested that exosomes derived from neural stem cells (NSCs) may hold promise as attractive candidates for SCI treatment. Epidermal Growth Factor Receptor positive NSC (EGFR+NSC) is a subpopulation of endogenous NSCs, showing strong regenerative capability in central nervous system disease. In the current study, we isolated exosomes from the EGFR+NSCs (EGFR+NSCs-Exos) and discovered that local delivery of EGFR+NSCs-Exos can effectively promote neurite regrowth in the injury site of spinal cord-injured mice and improve their neurological function recovery. Using the miRNA-seq, we firstly characterized the microRNAs (miRNAs) cargo of EGFR+NSCs-Exos and identified miR-34a-5p which was highly enriched in EGFR+NSCs derived exosomes. We further interpreted that exosomal miR-34a-5p could be transferred to neurons and inhibit the HDAC6 expression by directly binding to its mRNA, contributing to microtubule stabilization and autophagy induction for aiding SCI repair. Overall, our research demonstrated a novel therapeutic approach to improving neurological functional recovery by using exosomes secreted from a subpopulation of endogenous NSCs and providing a precise cell-free treatment strategy for SCI repair.
False-Negative Confirmatory Testing in Patients With Cannabinoid-Positive Urine Drug Screens
Authors: C. James Watson, Gwendolyn A. McMillin, Michele M. Burns
Journal: JAMA Pediatrics (2023)

This cross-sectional study discusses false-negative results associated with a change in the reporting threshold of 11-nor-9-carboxy-Δ9-tetrahydrocannabinol.
Analysis of <i>BRCA1</i>- and <i>BRCA2</i>-Related Pancreatic Cancer and Survival
Authors: Ben Boursi, E. Paul Wileyto, Ronac Mamtani, Susan M. Domchek, Talia Golan, Ryan Hood, Kim A. Reiss
Journal: JAMA Network Open (2023)

This cohort study compares the outcomes of patients with BRCA1 and BRCA -related pancreatic cancers using 2 large data sets.
Does discrimination prevent transgender and gender diverse people from seeking healthcare?: A nationwide cohort study in South Korea
Authors: Ranyeong Kim, Sungsub Choo, Hyemin Lee, Yun-Jung Eom, Horim Yi, Rockli Kim, Seung-Sup Kim
Journal: International Journal of Transgender Health (2023)

Introduction Using Asia's first nationwide cohort dataset, this study aimed to assess the prevalence of anti-transgender discrimination and healthcare avoidance and delay (HAD) and examine their associations among transgender and gender diverse (TGD) adults in South Korea.
The association between serum 25-hydroxyvitamin D levels and psoriasis in a large population-based cohort: a cross-sectional analysis of The Tromsø Study 2015–16
Authors: Marita Jenssen, Anne-Sofie Furberg, Rolf Jorde, Tom Wilsgaard, Kjersti Danielsen
Journal: British Journal of Dermatology (2023)

Abstract Background Case–control studies indicate an association between lower serum 25-hydroxyvitamin D [25(OH)D] levels and psoriasis. Data from larger population-based cohorts including mild cases are sparse. Objectives To investigate the association between 25(OH)D and psoriasis in a large population-based cohort, and assess possible effect modification by overweight. Methods Data from the Tromsø Study 2015–16 (Tromsø7), which included 19 520 participants from the general population aged 40–79 years, were subjected to a cross-sectional analysis. We assessed the shapes of the relationships between 25(OH)D and psoriasis using fractional polynomials. Odds ratios (ORs) for lifetime and active psoriasis were estimated using logistic regression. Adjusted models included month of blood sampling, body mass index (BMI), age and sex. Two-way and additive interaction between BMI and 25(OH)D were explored. Results From a total of 19 520 participants [10 203 women (52.3%); mean age 56.3 years (SD 10.4); mean 25[OH]D, 63.4 nmol L−1 (SD 21.9)], 2088 (10.7%) reported lifetime psoriasis and 1179 (6.0%) reported active psoriasis the past 12 months. There was no association between 25(OH)D and lifetime psoriasis [OR per 10 nmol L−1 increase in 25(OH)D 1.02, 95% confidence interval (CI) 0.99–1.04]. The relationship between 25(OH)D and active psoriasis was suggested to be nonlinear, but the model was not significant (P = 0.098). There was evidence for a superadditive effect (i.e. larger than the sum of the factors) of BMI &amp;gt; 27.5 kg m−2 and 25(OH)D &amp;lt; 25 nmol L−1 on the odds for active psoriasis (OR 1.92, 95% CI 1.18–3.12), but not for lifetime psoriasis (OR 1.41, 95% CI 0.93–2.15). There was no evidence for two-way interaction between BMI and 25(OH)D. Conclusions This large population-based study found no significant relationship between 25(OH)D and psoriasis. The analysis may have been underpowered to detect a threshold effect in the lower 25(OH)D spectrum. Interaction analysis indicates that high BMI and vitamin D deficiency combined increase the odds of active psoriasis more than the sum of these factors, with an estimated 92% higher odds for active psoriasis in participants with BMI &amp;gt; 27.5 kg m−2 and 25(OH)D &amp;lt; 25 nmol L−1. Providing advice to prevent vitamin D deficiency may be considered in the follow-up of overweight patients with psoriasis.
Durvalumab versus placebo with chemoradiotherapy for locally advanced cervical cancer (CALLA): a randomised, double-blind, phase 3 trial
Authors: Bradley J Monk, Takafumi Toita, Xiaohua Wu, Juan C Vázquez Limón, Rafal Tarnawski, Masaki Mandai, Ronnie Shapira-Frommer, Umesh Mahantshetty, Maria del Pilar Estevez-Diz, Qi Zhou, Sewanti Limaye, Francisco J Ramirez Godinez, Christina Oppermann Kussler, Szilvia Varga, Natalia Valdiviezo, Daisuke Aoki, Manuel Leiva, Jung-Yun Lee, Raymond Sulay, Yulia Kreynina, Wen-Fang Cheng, Felipe Rey, Yi Rong, Guihao Ke, Sophie Wildsmith, Andrew Lloyd, Hannah Dry, Ana Tablante Nunes, Jyoti Mayadev
Journal: The Lancet Oncology (2023)
Patterns of Cancer Incidence, Mortality, and Prevalence Across Five Continents: Defining Priorities to Reduce Cancer Disparities in Different Geographic Regions of the World
Authors: Farin Kamangar, Graça M. Dores, William F. Anderson
Journal: Journal of Clinical Oncology (2023)

Efforts to reduce global cancer disparities begin with an understanding of geographic patterns in cancer incidence, mortality, and prevalence. Using the GLOBOCAN (2002) and Cancer Incidence in Five Continents databases, we describe overall cancer incidence, mortality, and prevalence, age-adjusted temporal trends, and age-specific incidence patterns in selected geographic regions of the world. For the eight most common malignancies-cancers of lung, breast, colon and rectum, stomach, prostate, liver, cervix, and esophagus-the most important risk factors, cancer prevention and control measures are briefly reviewed.In 2002, an estimated 11 million new cancer cases and 7 million cancer deaths were reported worldwide; nearly 25 million persons were living with cancer. Among the eight most common cancers, global disparities in cancer incidence, mortality, and prevalence are evident, likely due to complex interactions of nonmodifiable (ie, genetic susceptibility and aging) and modifiable risk factors (ie, tobacco, infectious agents, diet, and physical activity). Indeed, when risk factors among populations are intertwined with differences in individual behaviors, cultural beliefs and practices, socioeconomic conditions, and health care systems, global cancer disparities are inevitable. For the eight most common cancers, priorities for reducing cancer disparities are discussed.
Flashback Foreword: Patterns of Cancer Incidence, Mortality, and Prevalence
Authors: Iona Cheng
Journal: Journal of Clinical Oncology (2023)

Article Tools FLASHBACK FOREWORD Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES Patterns of Cancer Incidence, Mortality, and Prevalence Across Five Continents: Defining Priorities to Reduce Cancer Disparities in Different Geographic Regions of the World. November 28, 2023 ARTICLE CITATION DOI: 10.1200/JCO.23.01512 Journal of Clinical Oncology - published online before print November 28, 2023 PMID: 38016280 Flashback Foreword: Patterns of Cancer Incidence, Mortality, and Prevalence Iona Cheng , PhD, MPH1,2xIona ChengSearch for articles by this author Show More 1Associate Editor, Journal of Clinical Oncology, Alexandria, VA2Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, CA https://doi.org/10.1200/JCO.23.01512 First Page Full Text PDF Figures and Tables © 2023 by American Society of Clinical OncologyTHE TAKEAWAYIn 2006, Kamangar et al1 enumerated the global burden of cancer of lung, breast, colon and rectum, stomach, prostate, liver, cervix, and esophagus and detailed priorities for cancer prevention and control. The impact of this global cancer surveillance was far reaching in establishing the foundation to build further cancer research and providing information for public health education and cancer prevention and control efforts.AUTHOR'S DISCLOSURES OF POTENTIAL CONFLICTS OF INTERESTFlashback Foreword: Patterns of Cancer Incidence, Mortality, and PrevalenceThe following represents disclosure information provided by the author of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/authors/author-center.Open Payments is a public database containing information reported by companies about payments made to US-licensed physicians (Open Payments).Iona ChengThis author is an Associate Editor for Journal of Clinical Oncology. Journal policy recused the author from having any role in the peer review of this manuscript.No other potential conflicts of interest were reported. Companion Patterns of Cancer Incidence, Mortality, and Prevalence Across Five Continents: Defining Priorities to Reduce Cancer Disparities in Different Geographic Regions of the World
Stereotactic body radiotherapy with or without selective dismutase mimetic in pancreatic adenocarcinoma: an adaptive, randomised, double-blind, placebo-controlled, phase 1b/2 trial
Authors: Cullen M Taniguchi, Jessica M Frakes, Todd A Aguilera, Manisha Palta, Brian Czito, Manoop S Bhutani, Lauren E Colbert, Joseph Abi Jaoude, Vincent Bernard, Shubham Pant, Ching-Wei D Tzeng, Dae Won Kim, Mokenge Malafa, James Costello, Geena Mathew, Neal Rebueno, Eugene J Koay, Prajnan Das, Ethan B Ludmir, Matthew H G Katz, Robert A Wolff, Sam Beddar, Gabriel O Sawakuchi, Shalini Moningi, Rebecca S Slack Tidwell, Ying Yuan, Peter F Thall, Robert A Beardsley, Jon Holmlund, Joseph M Herman, Sarah E Hoffe
Journal: The Lancet Oncology (2023)
Endoscopy International Open – recently published
Journal: Endoscopy (2023)

Endoscopy International Open (EIO) now has a Journal Impact Factor: 2.6! EIO is fully indexed in PubMed Central (PMC), the worldʼs leading biomedical literature database for open access content. Citations and abstracts of all EIO articles are retrievable in PMC through keyword and author searches. Below please discover our EIO highlights of the month. Find these and other interesting new publications on our e-journals platform https://eref.thieme.de/SC6IX or at https://eref.thieme.de/A4GJ8
ESGE news and upcoming events December 2023
Journal: Endoscopy (2023)

Our annual meeting promises to be a highlight in every endoscopistʼs year with one full day of live endoscopy from Berlinʼs Sana Klinikum Lichtenberg, specialist pathways from green endoscopy to ERCP, 11 scientific partnering societies from across the globe and 190 faculty members from 25 different countries!
Peroral endoscopic myotomy for Zenker’s diverticulum without tunneling
Authors: Georgios Mavrogenis, Fateh Bazerbachi
Journal: Endoscopy (2023)

Peroral endoscopic myotomy (POEM) is an increasingly adopted strategy for the treatment of Zenker’s diverticulum ([Fig. 1]). The Z-POEM technique allows for a deep incision of the cricopharyngeal muscle up to its transition to the esophageal muscle layer, and therefore more complete myotomy than direct diverticulotomy. Several modifications of the standard technique have been demonstrated [1] [2] [3]. The mucosal incision is most commonly performed over the septum, and two tunnels are created along the cricopharyngeal muscle. Next, the muscle is transected. Recently, we have described a variation of this technique with the creation of a single tunnel instead of two, to shorten the duration of the procedure [3]. However, we have now shifted to a novel approach that obviates the need for double or single tunneling ([Video 1]).
Endoscopy E-Videos – recently published
Journal: Endoscopy (2023)

Comment on: Multipolar adaptive traction makes endoscopic submucosal dissection feasible for large neoplastic area of the fundus in patient with familial adenomatous polyposisEndoscopy 2023; 55(S 01): E963-E964DOI: 10.1055/a-2135-8682 Comment on: Saline-tunneling endoscopic intermuscular dissection for the removal of rectal cancer using the hydrodissection methodEndoscopy 2023; 55(S 01): E987-E989DOI: 10.1055/a-2142-4654 Comment on: “Tip-in underwater endoscopic mucosal resection” without submucosal injection for superficial nonampullary duodenal adenomasEndoscopy 2023; 55(S 01): E965-E966DOI: 10.1055/a-2134-9080 Comment on: Use of atrial septal occluder in the treatment of chronic fistula following post-esophagectomy anastomotic leakEndoscopy 2023; 55(S 01): E1005-E1007DOI: 10.1055/a-2134-8709
Colonoscopy setting and impact on statistical significance in Artificial Intelligence trials
Authors: Marco Spadaccini, Emanuele Rondonotti, Franco Radaelli, Yuichi Mori, Cesare Hassan, Alessandro Repici
Journal: Endoscopy (2023)

See also: Evaluation of a real-time computer-aided polyp detection system during screening colonoscopy: AI-DETECT studyEndoscopy 2023; 55(04): 313-319DOI: 10.1055/a-1966-0661 See also: Reply to Spadaccini M. et al.Endoscopy 2023; 55(12): 1152-1152DOI: 10.1055/a-2147-0532
Marburg virus disease outbreaks, mathematical models, and disease parameters: a systematic review
Authors: Gina Cuomo-Dannenburg, Kelly McCain, Ruth McCabe, H Juliette T Unwin, Patrick Doohan, Rebecca K Nash, Joseph T Hicks, Kelly Charniga, Cyril Geismar, Ben Lambert, Dariya Nikitin, Janetta Skarp, Jack Wardle, Mara Kont, Sangeeta Bhatia, Natsuko Imai, Sabine van Elsland, Anne Cori, Christian Morgenstern, Aaron Morris, Alpha Forna, Amy Dighe, Anne Cori, Arran Hamlet, Ben Lambert, Charlie Whittaker, Christian Morgenstern, Cyril Geismar, Dariya Nikitin, David Jorgensen, Ed Knock, Ettie Unwin, Gina Cuomo-Dannenburg, Hayley Thompson, Isobel Routledge, Janetta Skarp, Joseph Hicks, Keith Fraser, Kelly Charniga, Kelly McCain, Lily Geidelberg, Lorenzo Cattarino, Mara Kont, Marc Baguelin, Natsuko Imai, Nima Moghaddas, Patrick Doohan, Rebecca Nash, Ruth McCabe, Sabine van Elsland, Sangeeta Bhatia, Sreejith Radhakrishnan, Zulma Cucunuba Perez, Jack Wardle
Journal: The Lancet Infectious Diseases (2023)
Enhancing accuracy and clinical advice: factors to consider in breast reconstruction for Hodgkin lymphoma survivors
Authors: Yang Qu, Fan Yang, Yidong Zhou
Journal: International Journal of Surgery (2023)

aDepartment of Breast Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China bDepartment of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Yang Qu and Fan Yang contributed equally to this work. Assistance with the study: none. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding Author. Address: Department of Breast Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Tel: +86 135 0107 8228. E-mail address: [email protected] (Y. Zhou). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0/
Comment on ‘Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus R0 resection for resectable colorectal cancer with peritoneal metastases and low peritoneal cancer index scores: A collaborative observational study from Korea and Japan’
Authors: Bo Pei, Jia Zhu, Lin Lai
Journal: International Journal of Surgery (2023)

aDepartment of oncology,Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi,China bDepartment of clinical medicine, Hubei Enshi College, Enshi,China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of oncology, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi, 445000, China. Tel.: +8607188290965. E-mail address: [email protected] (P. Bo). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
A commentary on ‘Augmented reality-assisted navigation system contributes to better intraoperative and short-time outcomes of laparoscopic pancreaticoduodenectomy: a retrospective cohort study’
Authors: Zhixiong Hu, Xiaoping Wei
Journal: International Journal of Surgery (2023)

Department of HPB Surgery, The Second Affiliated Hospital of Kunming Medical University, the Second Clinical College at Kunming Medical University, Kunming, Yunnan, People's Republic of China There is no data statement in this article Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of HPB Surgery, The Second Affiliated Hospital of Kunming Medical University, 374 Burma Road, Kunming 650101, Yunnan, People's Republic of China. Tel: +86 138 8899 0023. fax: +86 871 6535 1281. E-mail address: [email protected] (X. Wei). This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0/
Application and development of noninvasive biomarkers for colorectal cancer screening
Authors: Yubin Yang, Jian Wang, Jianan Lin, Chunlin Wu
Journal: International Journal of Surgery (2023)

Department of Pathology, the Second affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article Published online ■ ■ *Corresponding author. Address: Department of Pathology, the Second affiliated Hospital of Fujian Medical University, Quanzhou, 362000, PR. China. E-mail address: [email protected] (C. Wu). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/