tbuckley/cabot-search huggingface dataset:
Current Appraisal of Diagnosis and Treatment of Bronchogenic Carcinoma
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pneumocystis carinii Pneumonia
Authors: William K. Lau
Journal: JAMA (1976)

To determine if examination of respiratory secretions is useful in diagnosing<i>Pneumocystis carinii</i>pneumonia, smear preparations of expectorated sputum, tracheal aspirates, and transtracheal aspirates stained by the Gomori methenamine silver nitrate method were examined. Pneumocysts were observed more frequently in material obtained by transtracheal aspiration than in secretions obtained by the other methods. Transtracheal aspiration yielded material containing pneumocysts in 8 (13%) of 60 patients; each had pulmonary infiltrates and clinical courses consistent with<i>P carinii</i>pneumonia. Of 330 smear preparations examined from expectorated sputum, three patients had pneumocysts in their sputum and one had organisms in both transtracheal aspiration and expectorated sputum; all three had pneumonia. This study provides evidence that transtracheal aspiration is a useful initial step in the approach to the diagnosis of<i>P carinii</i>pneumonia. (<i>JAMA</i>236:2399-2402, 1976)
The development and severity of alcoholic hepatitis is associated with decreased intestinal microbiome-derived secondary bile acid isoursodeoxycholic acid
Authors: Mark Muthiah, Ekaterina Smirnova, Puneet Puri, Naga Chalasani, Vijay Shah, Kayla Gelow, Faridoddin Mirshahi, Arun Sanyal
Journal: Journal of Hepatology (2020)
Multiparameter flow cytometry as a tool to evaluate antipsoriatic therapy
Authors: C.P. GLADE, P.E.J. ERP, J.B.M. BOEZEMAN, P.C.M. KERKHOF
Journal: British Journal of Dermatology (1997)

Objective comparison of different antipsoriatic therapies requires quantitative assessment of disease severity.However, clinical assessment with the widely used Psoriasis Area and Severity Index (PASI)inaccuracy.An alternative is the quantitative analysis of different epidermal cell parameters using multiparameter flow cytometry.Our aim in the present study was to compare the clinical and flow cytometric approach to monitor disease activity and to evaluate antipsoriatic efficacy.Clinical scores for erythema, induration and scaling were assessed and biopsies for flow cytometric analysis were obtained from the psoriatic plaques of 89 patients before and after treatment with different therapeutic regimens consisting of vitamin D3 analogues and cortico steroids.In total, 219 epidermal cell suspensions were analysed using triple-labelling, with the simultaneous staining of markers for epidermal proliferation (DNA dye TO-PRO-3), differentiation (antikeratin 10), and inflammation (antivimentin).Correlation analysis was performed on 166 paired values obtained from 83 patients.A highly
Ampicillin-resistant Haemophilus influenzae type B infection
Authors: M. O. Tomeh
Journal: JAMA (1974)

Ampicillin-resistant<i>Haemophilus influenzae</i>type B was isolated from four children: two with meningitis, one with septicemia, and one with otitis media. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the isolates, tested by tube dilution assays, were 6.25μg to 50μg/ml and 12.5μg to greater than 50μg/ml, respectively. Epidemiological studies demonstrated a link between the two patients with meningitis and suggest that the infection in the child with septicemia was hospital-associated. These cases emphasize the need for careful sensitivity testing of significant<i>H influenzae</i>isolates. The poor response to ampicillin in at least one of our cases suggests revision in management of severe<i>H influenzae</i>infections according to local experience. (<i>JAMA</i>229:295-297, 1974)
Probable Transmission of Multidrug-Resistant Tuberculosis in Correctional Facility—California
Journal: JAMA (1993)

During 1990-1991, an inmate in a California prison spent a total of 6 months in the prison infirmary with multidrug-resistant tuberculosis (MDR-TB). As a result, from November 1990 through March 1991, 11 of the 21 prison infirmary physicians and nurses underwent tuberculin skin testing; two persons could be documented as newly positive. In addition, two correctional officers (from an unknown number tested) also had newly positive tuberculin skin tests. State and local departments of health, industrial relations, and corrections investigated the possibility of nosocomial TB transmission from inmates to staff. This report presents the findings from their investigation.
Credibility, Cookbook Medicine, and Common Sense
Authors: Peter E. Dans
Journal: Annals of Internal Medicine (1994)

Letters1 December 1994Credibility, Cookbook Medicine, and Common SensePeter E. Dans, MD, Deputy EditorPeter E. Dans, MD, Deputy EditorSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-11-199412010-00041 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Jones and I are probably more in agreement than his letter suggests. However, he appears to have conflated his deep distrust of guideline developers with the act of developing them and with the guidelines themselves. Here, we clearly disagree. Osler aptly defined medicine as “the art of probability and the science of uncertainty.” Few medical questions are settled forever or, for that matter, for very long. Although the assertion that medical knowledge has “a half-life of five years” [1] may be extreme, the erosion of today's certainties makes practicing medicine difficult and explains its wide variability. Thus, ...Reference1. Benjamin WW. Healing by the fundamentals. N Engl J Med. 1984; 311:595-7. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1994Volume 121, Issue 11Page: 898-899 Issue Published: 1 December 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Death caused by recreational cocaine use
Authors: C. V. Wetli
Journal: JAMA (1979)

Sixty-eight deaths associated with the recreational use of illicit cocaine were investigated by the Medical Examiner's Office of Dade County in Florida. Most fatalities occurred since 1975. Although 29 involved the use of other drugs (usually heroin), 24 persons died directly of the toxic effects of cocaine. Respiratory collapse and death occurred rapidly after the intravenous injection of cocaine. Oral or nasal ingestion resulted in a symptom-free interval lasting as long as an hour followed suddenly by generalized seizures and death. Toxicological analysis could not causally relate lidocaine hydrochloride or other adulterants to the untoward reactions. The data suggest that the rate of absorption, the peak blood concentration, and the prior use of cocaine all contribute to the possibility of a fatal reaction. Despite current belief, cocaine cannot be considered a safe recreational drug. (<i>JAMA</i>241:2519-2522, 1979)
Cholesterol 7alpha-hydroxylase activities from human and rat liver are modulated in vitro posttranslationally by phosphorylation/dephosphorylation
Authors: L Nguyen
Journal: Hepatology (1996)

Purified cholesterol 7alpha-hydroxylases (C7alphaH) from human and rat liver microsomes, and from transformed Escherichia coli expression systems, were incubated with 0.3 mmol/L [gamma-32P] adenosine triphosphate (ATP) in the presence and absence of bacterial alkaline phosphatase (AP) or rabbit muscle adenosine 3',5'-cyclic monophosphate (cAMP)-dependent protein kinase. The amounts of 32P incorporation after separation of human and rat C7alphaH proteins by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) were related to C7alphaH catalytic activities (determined by a radioisotope incorporation method) and enzyme protein mass (determined by Western blotting and laser densitometry). Both human and rat C7alphaH activities significantly decreased after dephosphorylation by AP (-57% - -72%) and increased up to twofold with phosphorylation by rabbit muscle cAMP-dependent protein kinase. The increases in C7alphaH activities were proportional to the amounts of cAMP-dependent protein kinase used, and were coupled to 32P incorporation into the purified enzymes. Both the activation of C7alphaH and the amounts of 32P incorporation were time-dependent and reached a maximum after 1 hour of incubation with 5 U of cAMP-dependent protein kinase. In a second set of experiments, purified human and rat liver C7alphaH were dephosphorylated by 30-minute incubation with AP, followed by inactivation of the phosphatase by the inhibitor NaF, and rephosphorylation of C7alphaH by 30-minute incubation with rabbit muscle cAMP-dependent protein kinase or bovine heart cAMP-independent protein kinase. Rephosphorylation of the dephosphorylated C7alphaH proteins by cAMP-dependent protein kinase increased C7alphaH catalytic activities up to fourfold, and the stimulation in catalytic activities paralleled the increases in 32P incorporation into the purified enzymes. Bovine heart protein kinase was as potent as rabbit muscle cAMP-dependent protein kinase in stimulating catalytic activity and 32P incorporation into the human C7alphaH protein. Because the protein mass of these purified enzymes did not change, the short-term regulation or catalytic efficiency of C7alphaH (activity per protein mass unit) is modulated, in vitro, posttranslationally by a phosphorylation/dephosphorylation mechanism in both the human and the rat enzymes. (Hepatology 1996 Dec;24(6):1468-74)
"Panárketon."
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Latrogenic Diseases
Authors: John J. Massarelli
Journal: JAMA (1980)

Even if we accept "caused by a physician" as the definition of iatrogenic (and not "cause of a physician" as proposed, with tongue in cheek, by Sir Douglas Black), this book seems to be incorrectly named. It deals comprehensively with diseases that can be caused by drugs, but not with diseases that physicians can induce by other means. My<i>Webster's Third New International Dictionary</i>says that iatrogenic means "induced by a physician—used chiefly of imagined ailments induced in a patient by autosuggestion based on a physician's words or actions during an examination." But this sort of iatrogenic disease is not considered at all in the present work, nor are the harmful effects of radiation or mechanical devices used by physicians discussed. If the reader understands that this is a volume on drug-induced diseases, he will find it an excellent one on that subject. In the first chapter the authors discuss
Research Issues Involving HIV-Associated Tuberculosis in Resource-Poor Countries
Authors: Kevin M. De Cock
Journal: JAMA (1996)

Each year, there are an estimated 8 million new cases of tuberculosis (TB) and 3 million deaths due to TB, most of which occur in resource-poor countries. Tuberculosis incidence is increasing rapidly in countries with high rates of human immunodeficiency virus (HIV) infection, and despite the availability of effective interventions, many TB programs are failing to cope with the increased TB caseload. This report highlights gaps in current understanding of the interaction between TB and HIV that contribute to failure of optimal TB management and control; we focus on the diagnosis of TB, its epidemiology and transmission, preventive strategies, and programmatic issues in the integration of HIV and TB services. Research into how best to apply existing knowledge will be at least as important as searching for new knowledge. The global control of TB will also require increased resources, greater political commitment, and stronger international public health leadership.
SURGEON-GENERAL STERNBERG.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 785: MesP1 Induces Vertebrate Cardiovascular Differentiationby Dkk-1 Mediated Blockage Of Wnt-signalling
Authors: Robert David, Christoph Brenner, Juliane Stieber, Stefan Brunner, Florian Schwarz, Ralph Rupp, Josef Mueller-Hoecker, Wolfgang-Michael Franz
Journal: Circulation (2007)

Cardiovascular diseases are the most frequent cause of death in the western world. Stem cell based cardiovascular repair will require in-depth understanding of molecular mechanisms underlying cardiovascular ES cell differentiation in vitro . A candidate cardiovascular fate inducer is the bHLH transcription factor Mesp1. As one of the earliest cardiovascular markers it is specifically expressed in almost all precursors of the cardiovascular system and required for cardiac morphogenesis. However, the mode of action of MesP1 in the underlying processes is unknown. Here we show in overexpression experiments using Xenopus embryos that MesP1 is the first known single transcription factor sufficient to induce ectopic beating heart tissue in vertebrates. Furthermore, MesP1 overexpression in ES cells results in significantly increased cardiovasculogenesis. Electrophysiological analysis of isolated beating cardiomyocytes showed all subtypes described for cardiac ES cell differentiation. Our results from RT-PCRs reveal a prominent function of MesP1 within a gene regulatory cascade causing Dkk-1 mediated blockage of canonical wnt signaling non cell autonomously leading to upregulation of the endodermal transcription factor Hex. In ChiP and bandshift assays we confirmed the Dkk-1 promoter as a direct target for MesP1. We consider our studies as a starting point to further decipher the detailed molecular position of MesP1 within the complex networks involved in cardiovasculogenesis. This knowledge will be a prerequisite to program ES cells towards a cardiovascular fate for cell therapy and cardiovascular tissue engineering. Likewise, it will be of great interest to transfer this approach to various subpopulations of human adult stem cells which still have not definitively been shown to bear cardiac transdifferentiation potential in their native state.
No link exists between pertussis vaccination and wheezing illnesses in young children
Journal: BMJ (1999)

Haemophilus influenzae type b vaccine is not linked to diabetes Environmental risk factors for type 1 diabetes remain unknown.It has been speculated that some vaccines might trigger it, although data are lacking.On p 1169 Karvonen et al describe their findings from a nationwide randomised study on the association between Haemophilus influenzae type b vaccination and type 1 diabetes in Finland, which has the highest incidence of type 1 diabetes.The risk of type 1 diabetes during the first 10 years of life was similar in children vaccinated with H influenzae type b at 3 months and those immunised at 24 months only.Moreover, the incidence of the disease in the immunised children was no different from that in those children born during the two years before the start of the vaccination programme.It is unlikely that H influenzae vaccination causes type 1 diabetes in children.
Abstracts
Journal: Annals of the Rheumatic Diseases (1969)

The value of monthly injections of benzathine peni- cillin (1 -2 megaunits) in preventing recurrences of rheu- matic fever is well established.The two main disadvantages of this type of therapy are the pain experienced on injection and the need for the patient to attend each month for such injection.In an attempt to find a con- venient and efficient alternative, the authors of this paper from Irvington House Rheumatic Fever Prophylaxis Research Clinic, New York, and West Haven Veterans Administration Hospital and Yale University School of Medicine, New Haven, Connecticut, compared the effi- cacy of the monthly regimen with that of a continuous oral penicillin regimen in which 400,000 u. were given three times a day for the first 10 days of each month, followed by 400,000 u. a day in a single dose for the rest of the month.A total of 343 patients aged 5 to 17 years was divided into two groups: 180 received oral potassium penicillin in the above dosage and 163 were given monthly injec- tions.The two groups were similar both in age distri- bution and in proportionate cardiac status.After four years of follow-up studies the attack rates per 100 patient- years were 6-6 for streptococcal infections and 0 6 for rheumatic recurrences in the monthly injection group; the corresponding values in the orally treated group were 22 -7 and 4*8, the differences being statistically significant (P = 0-01 and 0 02 respectively).This result clearly demonstrates the superiority of the monthly injection regimen.The authors discuss the reasons for the failure of the oral administration of penicillin to prevent recurrences of rheumatic fever but admit that these are not clear.
Medicare payment dispute may stymie flu shots
Authors: C. Marwick
Journal: JAMA (1993)

THE EFFORT to get as many people as possible immunized against influenza in the coming season may be stymied before it starts, thanks to what some physicians regard as inadequate reimbursement for administration of the vaccine. With considerable fanfare this summer, the Medicare program announced that for the first time it would reimburse its beneficiaries for influenza vaccinations. But even as the word went out that the agency expected as many as 15 million of the 36 million Medicare beneficiaries to line up for their free flu shots, there was rumbling that some physicians had decided not to participate in the program because the fee they receive from the Health Care Financing Administration (HCFA) fails to cover their costs of giving it. How many physicians are in fact proposing not to participate in the program is unknown. But, says David Fedson, MD, "I have been told by the American Lung
Correction
Authors: Uwe Schmidt, Emile van den Akker, Martine Parren-van Amelsvoort, Gabi Litos, Marella de Bruijn, Laura Gutiérrez, Rudi W. Hendriks, Wilfried Ellmeier, Bob Löwenberg, Hartmut Beug, Marieke von Lindern
Journal: The Journal of Experimental Medicine (2004)
'Stimulon': Critical in Hepatitis and Oncogenesis?
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health status of detained and incarcerated youths. Council on Scientific Affairs
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal