tbuckley/cabot-search huggingface dataset:
Hypnosis for Diagnosis
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Strongyloidiasis in US veterans of the Vietnam and other wars
Authors: R. M. Genta
Journal: JAMA (1987)

The prevalence of strongyloidiasis among American veterans of the Vietnam and other wars was evaluated by testing several groups of veterans for serum IgG antibodies against<i>Strongyloides stercoralis</i>antigens, using an enzyme-linked immunosorbent assay. Of 493 Vietnam veterans, eight (1.6%) were seropositive. Of 60 patients with abdominal symptoms and/or elevated eosinophilia (&gt;0.08 [&gt;8%]) admitted to the Cincinnati Veterans Administration Medical Center, 12 (5%) were seropositive. Of 147 residents of a Veterans Administration—operated nursing home, six (4%) were seropositive. All infected patients in the latter two groups were World War II veterans. The usefulness of the enzyme-linked immunosorbent assay as a screening tool for at-risk groups is suggested by the finding that<i>S stercoralis</i>larvae were demonstrated in most seropositive patients when a sufficient number of fresh stools were examined. (<i>JAMA</i>1987;258:49-52)
2ND-Line Therapies After 1st-Line Therapy with Folfiri in Combination with Cetuximab or Bevacizumab in Patients with KRAS Wild-Type Metastatic Colorectal Cancer (MCRC)-Analysis of the AIO KRK 0306 (FIRE 3)- Trial
Authors: D. Modest, S. Stintzing, L. Fischer von Weikersthal, T. Decker, A. Kiani, U. Vehling-Kaiser, S.E. Al Batran, T. Heintges, C. Lerchenmüller, C. Kahl, G. Seipelt, F. Kullmann, M. Stauch, W. Scheithauer, S. Held, C. Giessen, A. Jung, R. Kirchner, V. Heinemann
Journal: Annals of Oncology (2014)
Farsightedness
Authors: Roger P. Smith
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The mathematics used by Dr Hammerschmidt<sup>1</sup>in developing his final guidelines are precise and well presented. However, there are some even quicker "rules of thumb" for those of us whose calculators are low on batteries. Regarding the projected image size, the "rule of eight" may be useful: multiply the screen letter size, in inches, by eight to get the maximum viewing distance, in feet. (A 10-in [25.45-cm] letter will be readable at 80 ft [24.43 m].) Don't forget that no one should be seated beyond an angle of 30° to the screen, because most screens will reflect very little light beyond this angle. Other simple guidelines are readily available from many commercial slide suppliers, the photographic industry, and contemporary publications.<sup>2</sup> I applaud Dr Hammerschmidt for his efforts on behalf of improved slide presentations; improved slides are always worthy of applause.
Concordance of tumor cell (TC) and immune cell (IC) staining with Ventana SP142, Ventana SP263, Dako 28-8 and Dako 22C3 PD-L1 IHC tests in NSCLC patient samples.
Authors: Marietta L. Scott, Marianne J Ratcliffe, Alan Sharpe, Craig Barker, Paul Scorer, Marlon Rebelatto, Hytham Al-Masri, Jill Walker
Journal: Journal of Clinical Oncology (2017)

e14503 Background: PD-1/PD-L1 directed antibodies are emerging as effective oncology therapeutics with multiple diagnostic PD-L1 tests available for patient segmentation. It is essential to compare these assays to understand the risk if assays are used interchangeably. Previous data showed strong concordance (OPA &gt;85%) of TC PD-L1 expression at multiple clinically relevant cutoffs with the Ventana SP263, Dako 28-8 and 22C3 assays (Ratcliffe et al. Clin Cancer Res 2017; Ratcliffe et al. ESMO 2016 (955PD)). This work supplements previous data with concordance of IC scoring and data from Ventana SP142. Methods: IC PD-L1 IHC expression data were generated from 493 clinical NSCLC biopsy samples stained with Ventana SP263 and Dako 22C3 and 28-8 assays. In addition, consecutive sections from 200 blocks of the 493 samples were later sectioned and stained with SP142 and SP263. Concordance at matched cutoffs between the 4 assays is reported for IC, and concordance between SP263 and SP142 for TC. Results: Strong agreement in IC scoring between the SP263 and 22C3 and 28-8 assays is observed. The SP142 assay showed lower IC concordance and reduced TC PD-L1 staining/concordance vs SP263 (Table). Conclusions: Analytical similarity is shown between the SP263, 28-8 or 22C3 assays when measuring TC or IC PD-L1 expression, with high concordance between patient classification at matching TC cutoffs up to ≥50% or IC up to ≥10%, strengthening the evidence that these 3 assays could be used interchangeably at relevant clinical cutoffs. The SP142 assay shows clear analytical differences in both IC and TC staining. [Table: see text]
The coast is cleaner.
Journal: Environmental Health Perspectives (1999)

Forumchoice.The World Health Organization has found that d-phenothrin is not likely to pose a threat to human health when used properly, and does not cause aller- gic, sensitizing, or other known health reactions.'We are required by the Indian government to spray our flights before descent and produce empty cans upon arrival," says Kevin Florence, NWA's manager of loss prevention."Failure to do so could result in the airplane being impounded, sent back to the city of ori- gin, or treated by local authorities."Florence says that NWA has also adopted the integrated pest management approach, which emphasizes more sus- tainable and environmentally healthier solutions for controlling pests in the company's fleet.Today, chemical companies are exploring new pest-control options for use on aircraft.Possible solutions include bait traps, the use of ultraviolet light, and integrated pest management.This law's a beach.The Beaches Environmental Awareness, Cleanup, and Health Act of 1999 aims to establish national beach monitoring and public notification standards.
Consequences of Selling a Kidney in India
Authors: Robert W. Steiner
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Constricting arteries expand views of ischemic heart disease
Authors: E. R. Gonzalez
Journal: JAMA (1980)

Without surgery, it was decided, the patient was as good as dead. "She was dreadfully afflicted with recurrent nocturnal anginal pains," recalled Albert A. Kattus, MD, of Inglewood, Calif, during the recent meeting of the American Heart Association (AHA) in Anaheim, Calif. "An angiogram showed a narrow place in one artery." Although the artery was only 60% occluded, the woman was scheduled for a coronary artery bypass graft. It was all the physicians could think of to do. Unknowingly, they were about to make medical history. The coronary artery had just been exposed, Kattus said, "when we suddenly saw the pattern of the electrocardiogram change. She was reenacting one of her episodes of angina. The artery itself was right there, before our eyes, and had gone into an intense constriction. As we saw it clamp down, we could feel it as though it were a tough piece of rope or
Comparing Epidemiologic Studies of Ingested Asbestos for Use in Risk Assessment
Authors: Linda S. Erdreich
Journal: Environmental Health Perspectives (1983)

Epidemiologic data can be used in risk assessment in various ways: to calculate the dose-response relationship between exposure levels and adverse effects; to establish ranges of exposure known to be safe or unsafe; to verify an endpoint in humans derived from a route or species extrapolation; to support assumptions necessary for performing extrapolation procedures. These points are illustrated in the risk assessment for exposure to asbestos in drinking water. A previous risk assessment for asbestos, the EPA's Ambient Water Quality Criteria (AWQC) for Asbestos, was derived from cohort studies of inhalation exposure. Epidemiologic studies of ingested asbestos, all of geographical correlation design, were compared on the basis of their ability to add information in support of both the route extrapolation and low-dose extrapolation used in this risk assessment. Results of these ingestion studies were inconsistent due to variable ability to detect a risk from chronic low-level exposure. After preliminary comparisons of factors that determine scientific validity and statistical power, two ingestion studies were selected to determine if they had the potential to detect the risk predicted by the AWQC. This evaluation has shown that these studies do not offer quantitative data for estimating levels associated with a defined risk. Due to short exposure duration and limited power, clearly safe and clearly unsafe ranges could not be definitely identified. The most appropriate ingestion studies suggest, but do not prove, the endpoint derived from the route extrapolation in the AWQC.
Pneumococcal Vaccine
Authors: Gene H. Stollerman
Journal: JAMA (1982)

<h3>To the Editor.—</h3> As one who served as chairman of the Advisory Panel on Bacterial Vaccines and Toxoids of the Bureau of Biologics at the time that licensure for the pneumococcal vaccine was recommended, I am obliged to respond to J. V. Hirschmann, MD, and Benjamin A. Lipsky, MD, who in their recent article (1981;246:1428) concluded: "The [Food and Drug Administration] licensed the pneumococcal vaccine for use in the general population before its benefits and risks were clearly delineated." Convincing clinical data of the efficacy of the pneumococcal vaccine were obtained by demonstrating its protection of humans who were naturally challenged by serious infections caused by the specific organisms against which the vaccine was constituted. The fact that the populations selected sometimes had to be unique to find a high incidence of bacteremic pneumococcal pneumonias (eg, African gold miners, New Guinea natives, military units) does not detract from their value
Compassion Fatigue
Authors: Eric W. Booth
Journal: JAMA (1991)

<h3>To the Editor.</h3> ——The poignant reflections of Sweet<sup>1</sup>struck a chord. All physicians should bear in mind his closing question: which of our medical friends and colleagues might benefit from a listening ear? Unfortunately, physicians, whose major skill was once to be good listeners, seem to be losing this very important talent. I know this only too well from my own personal experiences. I have been very seriously ill, being totally bedridden and in excruciating pain for the last 5 years. Matters have reached such a serious point over the last few months that I feel that I do not wish to go on living while being forced to endure such unbearable suffering. Despite my feeling this way, I am unable to convey this to my medical colleagues. It is a very sad state of affairs that the people on whom I ought to be able to rely the
Pooks Received
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A CASE OF CHOREA AND ERYTHREMIA
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
I refused to perform abortions: you don't have to sacrifice your integrity to get ahead
Authors: None Anonymous
Journal: BMJ (2013)

Hydroxychloroquine (HCQ) has multiple potential antiviral mechanisms of action that differ according to the pathogen studied (eg, Chikungunya, Dengue virus, human immunodeficiency virus, poliovirus, Zika virus). Data on HCQ for treatment of coronavirus disease 2019 (COVID-19) are rapidly evolving. To date there is no evidence from randomized controlled trials that any single therapy improves outcomes in patients infected with COVID-19. There are also no clinical trial data supporting prophylactic HCQ therapy in COVID-19. Hydroxychloroquine (HCQ) use in patients with COVID-19 is being investigated examining prophylaxis, postexposure prophylaxis, and treatment regimens.
Abstract 3716: Conditional reprogramming technology for Next Generation Living Biobanks (NGLB)
Authors: Xuefeng Liu
Journal: Cancer Research (2019)

Abstract As one of the next generation biobanks, living biobanks (iPSC, organoids, CRC, PDX, etc.) and related functional analyses are rapidly growing in basic research, clinics, and industry (especially immune-oncology and targeting therapies) as well. Most recently NCI launched PDMR (patient-derived model repository) using PDX, CRC and organoid cultures, NCI/ATCC/Broad/Sanger launched HCMI (Human Cancer Models Initiative) using Organoids and CRC cultures. In this study, we established a conditional reprogramming (CR) protocol which allows to generate cell cultures from cryopreserve fresh tissue specimens from surgery, core biopsies, needle biopsies, and brushed cells.It has been extremely difficult to generate primary cultures from tumor specimens, it has not been possible to expand and indefinitely propagate cells derived from adult tissues while retaining lineage-commitment, normal growth control and differentiation potential. The CR method rapidly expands both normal and malignant epithelial cells from diverse anatomic sites and mammalian species and does not require transfection with exogenous viral or cellular genes. Establishment of cell cultures from both normal and tumor tissue (many types) is highly efficient. The robust nature of the technique is exemplified by the ability to produce 2 x 106cells in 5 days from a core biopsy of breast tumor. Normal cultures retain a normal karyotype and differentiation potential and cell lines derived from tumors retain their tumorigenic phenotype. We were also able to generate their corresponding fibroblast cultures from the same specimens. These fibroblasts can be immortalized by exogenously expressed hTERT. This approach allows to establish in vitro "epithelial-stroma interactions" to study normal cell differentiation and tumor microenvironment. The ability to produce inexhaustible cell populations from small biopsies and cryopreserved specimens has the potential to transform biobanking repositories (termed as NGLB - next generation living biobanks) and current pathology practice by enabling genetic, biochemical, metabolomic, proteomic, and biological assays, including chemosensitivity testing as a functional diagnostics tool (or a living biomarker) for precision cancer medicine. CR cells can be also an inexhaustible resource to generate CR cells derived iPSC, organoids, and xenografts (CDXs). Citation Format: Xuefeng Liu. Conditional reprogramming technology for Next Generation Living Biobanks (NGLB) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3716.
Imported Dracunculiasis--United States, 1995 and 1997
Journal: JAMA (1998)

Dracunculiasis is a parasitic infection caused by a filarial worm (Dracunculus medinensis [i.e., Guinea worm]) that is transmitted through contaminated drinking water. Approximately 1 year after a person is infected, one or more meter-long adult female worms begin to emerge through the skin, often incapacitating the patient for > or =2 months. Despite a dramatic decrease in cases worldwide, dracunculiasis is still occasionally imported into the United States. Since 1995, two cases of dracunculiasis have been reported in the United States, both imported from Sudan. This report summarizes the investigation of these cases.
A randomized trial of exercise training in patients with coronary heart disease
Authors: V. Froelicher
Journal: JAMA (1984)

In order to determine whether or not regular exercise could alter myocardial perfusion or function, we randomized 146 male volunteers with stable coronary heart disease to either a supervised exercise program (n=72) or to a usual care program (n=74). Subjects underwent exercise tests initially and one year later. Significant differences between the two groups included improved aerobic capacity, thallium ischemia scores, and ventricular function in the exercise intervention group. It was not possible to classify the conditions of patients as to the likelihood of improvement or deterioration. This study demonstrated changes in myocardial perfusion and function in a select group of middle-aged men with coronary heart disease who underwent a medically appropriate exercise program lasting one year, but these changes were relatively modest. (<i>JAMA</i>1984;252:1291-1297)
Practical Talks on Heart Disease
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiovascular assist devices in cardiogenic shock
Authors: R. M. Gunnar
Journal: JAMA (1976)

AT PRESENT, mechanical circulatory assistance is practical and advantageous for treatment of patients with cardiogenic shock. This technique utilizes a nonocclusive, intraaortic balloon timed to the electrocardiogram (ECG) and monitored by the arterial pulse wave. The balloon inflates just after the aortic valve closes and deflates with the onset of ventricular systole. The inflation forces blood out of the central aorta during cardiac diastole, thereby decreasing central aortic blood volume and increasing pressure. At the onset of systole, balloon deflation decreases aortic pressure so that the left ventricle has less impedance to ejection. The increase in diastolic aortic pressure increases coronary blood flow, while the decreased aortic volume at the onset of systole decreases the work of the left ventricle. The balloon is inserted through the femoral artery and threaded to the descending thoracic aorta just below the origin of the left subclavian artery. Many balloons are designed so that
Smokers may pay, but not their own way
Authors: P. Cotton
Journal: JAMA (1994)

PREMATURE DEATH is not usually considered to be cost-effective. Yet the assumption that early death cuts future medical and Social Security expenditures is essential to the tobacco industry's assertion that cigarette sales taxes and excise taxes more than cover the cost to government of diseases caused by smoking. "If it weren't for that particular argument, there would be no way any calculation could show that smokers pay their own way," says Jeffrey E. Harris, MD, PhD, an internist and economics professor at the Massachusetts Institute of Technology, Cambridge. Harris told the US House Ways and Means Committee that even with the proposed 75-cent-per-pack tax increase being proposed to finance health system reform, nonsmokers will still be paying for more than half of smoking-related health care costs. Harris estimated in his congressional testimony that "cigarette smoking accounts for 8% of all health care spending in the United States," with a range