tbuckley/cabot-search huggingface dataset:
The Bidirectional Gut–Lung Axis in Chronic Obstructive Pulmonary Disease
Authors: Lei Wang, Yang Cai, Johan Garssen, Paul A. J. Henricks, Gert Folkerts, Saskia Braber
Journal: American Journal of Respiratory and Critical Care Medicine (2023)

Epidemiological studies indicate that chronic obstructive pulmonary disease (COPD) is associated with the incidence of changes in intestinal health. Cigarette smoking, as one of the major causes of COPD, can have an impact on the gastrointestinal system and promotes intestinal diseases. This points to the existence of gut–lung interactions, but an overview of the underlying mechanisms of the bidirectional connection between the lungs and the gut in COPD is lacking. The interaction between the lungs and the gut can occur through circulating inflammatory cells and mediators. Moreover, gut microbiota dysbiosis, observed in both COPD and intestinal disorders, can lead to a disturbed mucosal environment, including the intestinal barrier and immune system, and hence may negatively affect both the gut and the lungs. Furthermore, systemic hypoxia and oxidative stress that occur in COPD may also be involved in intestinal dysfunction and play a role in the gut–lung axis. In this review, we summarize data from clinical research, animal models, and in vitro studies that may explain the possible mechanisms of gut–lung interactions associated with COPD. Interesting observations on the possibility of promising future add-on therapies for intestinal dysfunction in patients with COPD are highlighted.
Analyzing Child Firearm Assault Injuries by Race and Ethnicity During the COVID-19 Pandemic in 4 Major US Cities
Authors: Jonathan Jay, Rachel Martin, Manish Patel, Kristal Xie, Faizah Shareef, Jessica T. Simes
Journal: JAMA Network Open (2023)

This cross-sectional study examines changes in rates and disparities of fatal and nonfatal firearm assaults among children in New York, Los Angeles, Chicago, and Philadelphia before and during the COVID-19 pandemic.
Long-Term Exposure to Nitrate and Trihalomethanes in Drinking Water and Prostate Cancer: A Multicase–Control Study in Spain (MCC-Spain)
Authors: Carolina Donat-Vargas, Manolis Kogevinas, Gemma Castaño-Vinyals, Beatriz Pérez-Gómez, Javier Llorca, Mercedes Vanaclocha-Espí, Guillermo Fernandez-Tardon, Laura Costas, Nuria Aragonés, Inés Gómez-Acebo, Victor Moreno, Marina Pollan, Cristina M. Villanueva
Journal: Environmental Health Perspectives (2023)

Background: Nitrate and trihalomethanes (THMs) in drinking water are widespread and are potential human carcinogens. Objective: We evaluated the association between drinking-water exposure to nitrate and THMs and prostate cancer. Methods: During the period 2008–2013, 697 hospital-based incident prostate cancer cases (97 aggressive tumors) and 927 population-based controls were recruited in Spain, providing information on residential histories and type of water consumed. Average nitrate and THMs levels in drinking water were linked with lifetime water consumption to calculate waterborne ingestion. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using mixed models with recruitment area as random effect. Effect modification by tumor grade (Gleason score), age, education, lifestyle, and dietary factors was explored. Results: Mean (±standard deviation) adult lifetime waterborne ingested nitrate (milligrams per day), brominated (Br)-THMs (micrograms per day), and chloroform (micrograms per day) were 11.5 (±9.0), 20.7 (±32.4), and 15.1 (±14.7) in controls. Waterborne ingested nitrate &gt;13.8 vs. &lt;5.5mg/d was associated with an OR of 1.74 (95% CI: 1.19, 2.54) overall, and 2.78 (95% CI: 1.23, 6.27) for tumors with Gleason scores ≥8. Associations were higher in the youngest and those with lower intakes of fiber, fruit/vegetables, and vitamin C. Waterborne ingested THMs were not associated with prostate cancer. Residential tap water levels of Br-THMs and chloroform showed, respectively, inverse and positive associations with prostate cancer. Conclusions: Findings suggest long-term waterborne ingested nitrate could be a risk factor of prostate cancer, particularly for aggressive tumors. High intakes of fiber, fruit/vegetables and vitamin C may lower this risk. Association with residential levels but not ingested chloroform/Br-THM may suggest inhalation and dermal routes could be relevant for prostate cancer. https://doi.org/10.1289/EHP11391
Vascular-Targeted Therapy for Systemic Lupus Erythematosus–Associated Vasculitis
Authors: Suzanne Xu, Robert J. Patrignelli, Sarika Ramachandran, Fotios Koumpouras, Deborah Desir, Christine J. Ko, Jeff R. Gehlhausen
Journal: JAMA Dermatology (2023)

This case report describes a woman in her 40s with a medical history of systemic lupus erythematosus with 1 year of tender papules, plaques, and progressive ulcers on her hands and feet.
<scp>IL</scp>‐4 drastically decreases deuterosomal and multiciliated cells via alteration in progenitor cell differentiation
Authors: Hyung‐Ju Cho, Youn Wook Chung, Sungmin Moon, Ju Hee Seo, Miran Kang, Jae Sung Nam, Sang‐Nam Lee, Chang‐Hoon Kim, Augustine M. K. Choi, Joo‐Heon Yoon
Journal: Allergy (2023)

Allergic inflammation affects the epithelial cell populations resulting in goblet cell hyperplasia and decreased ciliated cells. Recent advances in single-cell RNA sequencing (scRNAseq) have enabled the identification of new cell subtypes and genomic features of single cells. In this study, we aimed to investigate the effect of allergic inflammation in nasal epithelial cell transcriptomes at the single-cell level.We performed scRNAseq in cultured primary human nasal epithelial (HNE) cells and in vivo nasal epithelium. The transcriptomic features and epithelial cell subtypes were determined under IL-4 stimulation, and cell-specific marker genes and proteins were identified.We confirmed that cultured HNE cells were similar to in vivo epithelial cells through scRNAseq. Cell-specific marker genes were utilized to cluster the cell subtypes, and FOXJ1+ -ciliated cells were sub-classified into multiciliated and deuterosomal cells. PLK4 and CDC20B were specific for deuterosomal cells, and SNTN, CPASL, and GSTA2 were specific for multiciliated cells. IL-4 altered the proportions of cell subtypes, resulting in a decrease in multiciliated cells and loss of deuterosomal cells. The trajectory analysis revealed deuterosomal cells as precursor cells of multiciliated cells and deuterosomal cells function as a bridge between club and multiciliated cells. A decrease in deuterosomal cell marker genes was observed in nasal tissue samples with type 2 inflammation.The effects of IL-4 appear to be mediated through the loss of the deuterosomal population, resulting in the reduction in multiciliated cells. This study also newly suggests cell-specific markers that might be pivotal for investigating respiratory inflammatory diseases.
An alternative path to oral tolerance
Authors: Carmen H. Li, Ekaterina Kabak, Thomas Eiwegger
Journal: Allergy (2023)

CHL and EK have nothing to disclose. TE reports to act as local PI for company sponsored trials by DBV Therapeutics, Greer Stallergens, and sub-investigator for Regeneron and ALK-Abelló. He is Co-Investigator or scientific lead in three investigator-initiated oral immunotherapy trials supported by the SickKids Food Allergy and Anaphylaxis Program and serves as an associate editor for Allergy. He/his laboratory received unconditional/in-kind contributions from Macro Array Diagnostics and an unrestricted grant from ALK-Abelló. He holds advisory board roles for ALK-Abelló, VAMED, Nutricia/Danone, and Aimmune. TE reports lecture fees from Novartis, ThermoFisher, Nutricia/Danone, Aimmune, and ALK-Abelló.
Rapid On-Site Pathology Visualization of COVID-19 Characteristics Using Higher Harmonic Generation Microscopy
Authors: Laura M. G. van Huizen, Kirsten A. Kalverda, Marianna Bugiani, Venerino Poletti, Peter I. Bonta, Jouke T. Annema, Marie Louise Groot
Journal: American Journal of Respiratory and Critical Care Medicine (2023)

"Rapid On-Site Pathology Visualization of COVID-19 Characteristics Using Higher Harmonic Generation Microscopy." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
Coxsackievirus and Type 1 Diabetes: Diabetogenic Mechanisms and Implications for Prevention
Authors: Alexia Carré, Federica Vecchio, Malin Flodström-Tullberg, Sylvaine You, Roberto Mallone
Journal: Endocrine Reviews (2023)

Abstract The evidence for an association between coxsackievirus B (CVB) infection, pancreatic islet autoimmunity, and clinical type 1 diabetes is increasing. Results from prospective cohorts and pancreas histopathology studies have provided a compelling case. However, the demonstration of a causal relationship is missing, and is likely to remain elusive until tested in humans by avoiding exposure to this candidate viral trigger. To this end, CVB vaccines have been developed and are entering clinical trials. However, the progress made in understanding the biology of the virus and in providing tools to address the long-standing question of causality contrasts with the scarcity of information about the antiviral immune responses triggered by infection. Beta-cell death may be primarily induced by CVB itself, possibly in the context of poor immune protection, or secondarily provoked by T-cell responses against CVB-infected beta cells. The possible involvement of epitope mimicry mechanisms skewing the physiological antiviral response toward autoimmunity has also been suggested. We here review the available evidence for each of these 3 non-mutually exclusive scenarios. Understanding which ones are at play is critical to maximize the odds of success of CVB vaccination, and to develop suitable tools to monitor the efficacy of immunization and its intermingling with autoimmune onset or prevention.
Additional Outcomes and Limitations in the Treatment of Acute Unstable Chest Wall Injuries
Authors: Charlie Slowey, Anthony Divito, Lee Goeddel
Journal: JAMA Surgery (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Additional Outcomes and Limitations in the Treatment of Acute Unstable Chest Wall Injuries
Authors: Joseph D. Forrester, Evert A. Eriksson, Fredric M. Pieracci
Journal: JAMA Surgery (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Parasitic Infections and Biological Therapies Targeting Type 2 Inflammation: A VigiBase Study
Authors: Philippine Lifar, François Montastruc, Laurent L. Reber, Jean-François Magnaval, Laurent Guilleminault
Journal: American Journal of Respiratory and Critical Care Medicine (2023)

"Parasitic Infections and Biological Therapies Targeting Type 2 Inflammation: A VigiBase Study." American Journal of Respiratory and Critical Care Medicine, 207(9), pp. 1253–1255
Errors in Figure and Nonauthor Collaborators Supplement
Authors: Alessandra Moore, Douglas Smink, Erika Rangel
Journal: JAMA Surgery (2023)

Hanane Bouchghoul, MD, PhD; Catherine Deneux-Tharaux, MD, PhD; Aurore Georget, MSc; Hugo Madar, MD; Antoine Bénard, MD, PhD; Loïc Sentilhes, MD, PhD; TRAAP2 Study Group; Loïc Sentilhes; Catherine Deneux-Tharaux; Aurore Goerget; Antoine Benard; Hugo Madar; Marie-Victoire Sénat; Maëla Le Lous; Norbert Winer; Patrick Rozenberg; Gilles Kayem; Eric Verspyck; Florent Fuchs; Elie Azria; Denis Gallot; Diane Korb; Raoul Desbrière; Camille Le Ray; Céline Chauleur; Fanny De Marcillac; Franck Perrotin; Olivier Parant; Laurent Salomon J; Emilie Gauchotte; Florence Bretelle; Nicolas Sananès; Caroline Bohec; Nicolas Mottet; Guillaume Legendre; Vincent Letouzey; Bassam Haddad; Delphine Vardon; Alizée Froeliger; Hanane Bouchghoul; Valérie Daniel; Sophie Regueme; Caroline Roussillon; Astrid Darsonval
Incidence of Newborn Drug Testing and Variations by Birthing Parent Race and Ethnicity Before and After Recreational Cannabis Legalization
Authors: Sebastian Schoneich, Melissa Plegue, Victoria Waidley, Katharine McCabe, Justine Wu, P. Paul Chandanabhumma, Carol Shetty, Christopher J. Frank, Lauren Oshman
Journal: JAMA Network Open (2023)

Thirty-seven US states and the District of Columbia mandate reporting newborns with suspected prenatal substance exposure to the state, and punitive policies that link prenatal substance exposure to newborn drug testing (NDT) may lead to disproportionate reporting of Black parents to Child Protective Services. The impact of recreational cannabis legalization on racial disproportionality in NDT is unknown.To examine variations in the incidence and results of NDT by birthing parent race and ethnicity, variables associated with variation, and changes after statewide legalization of recreational cannabis.This retrospective cohort study was conducted from 2014 to 2020 with 26 366 live births to 21 648 birthing people who received prenatal care at an academic medical center in the Midwestern United States. Data were analyzed from June 2021 to August 2022.Variables included birthing parent age, race, ethnicity, marital status, zip code, insurance type, prenatal and newborn diagnoses codes, and prenatal urine drug test orders and results.The primary outcome was an NDT order. Secondary outcomes were substances detected.Among 26 366 newborns of 21 648 birthing people (mean [SD] age at delivery, 30.5 [5.2] years), most birthing parents were White (15 338 [71.6%]), were non-Hispanic (20 125 [93.1%]), and had private insurance coverage (16 159 [74.8%]). The incidence of NDT ordering was 4.7% overall (1237 newborns). Clinicians ordered more NDTs for Black compared with White newborns (207 of 2870 [7.3%] vs 335 of 17 564 [1.9%]; P < .001) when the birthing parent had no prenatal urine drug test, a presumably low-risk group. Overall, 471 of 1090 NDTs (43.3%) were positive for only tetrahydrocannabinol (THC). NDTs were more likely to be positive for opioids in White compared with Black newborns (153 of 693 [22.2%] vs 29 of 308 [9.4%]; P < .001) and more likely to be positive for THC in Black compared with White newborns (207 of 308 [67.2%] vs 359 of 693 [51.8%]; P < .001). Differences remained consistent after state recreational cannabis legalization in 2018. Newborn drug tests were more likely to be positive for THC after legalization vs before legalization (248 of 360 [68.9%] vs 366 of 728 [50.3%]; P < .001) with no significant interaction with race and ethnicity groups.In this study, clinicians ordered NDTs more frequently for Black newborns when no drug testing was done during pregnancy. These findings call for further exploration of how structural and institutional racism contribute to disproportionate testing and subsequent Child Protective Services investigation, surveillance, and criminalization of Black parents.
Associations Between Kidney Histopathologic Lesions and Incident Cardiovascular Disease in Adults With Chronic Kidney Disease
Authors: Leo F. Buckley, Insa M. Schmidt, Ashish Verma, Ragnar Palsson, Debbie Adam, Amil M. Shah, Anand Srivastava, Sushrut S. Waikar
Journal: JAMA Cardiology (2023)

Histologic lesions in the kidney may reflect or contribute to systemic processes that may lead to adverse cardiovascular events.
Diabetes Stigma and Clinical Outcomes in Adolescents and Young Adults: The SEARCH for Diabetes in Youth Study
Authors: Kelsey B. Eitel, Alissa J. Roberts, Ralph D’Agostino, Catherine E. Barrett, Ronny A. Bell, Anna Bellatorre, Angelica Cristello, Dana Dabelea, Lawrence M. Dolan, Elizabeth T. Jensen, Angela D. Liese, Elizabeth J. Mayer-Davis, Kristi Reynolds, Santica M. Marcovina, Catherine Pihoker
Journal: Diabetes Care (2023)

To examine the association between diabetes stigma and HbA1c, treatment plan and acute and chronic complications in adolescents and young adults (AYAs) with type 1 or type 2 diabetes.
Integrated Proteomics Unveils Nuclear PDE3A2 as a Regulator of Cardiac Myocyte Hypertrophy
Authors: Gunasekaran Subramaniam, Katharina Schleicher, Duangnapa Kovanich, Anna Zerio, Milda Folkmanaite, Ying-Chi Chao, Nicoletta C. Surdo, Andreas Koschinski, Jianshu Hu, Arjen Scholten, Albert J.R. Heck, Maria Ercu, Anastasiia Sholokh, Kyung Chan Park, Enno Klussmann, Viviana Meraviglia, Milena Bellin, Sara Zanivan, Svenja Hester, Shabaz Mohammed, Manuela Zaccolo
Journal: Circulation Research (2023)

Signaling by cAMP is organized in multiple distinct subcellular nanodomains regulated by cAMP-hydrolyzing PDEs (phosphodiesterases). Cardiac β-adrenergic signaling has served as the prototypical system to elucidate cAMP compartmentalization. Although studies in cardiac myocytes have provided an understanding of the location and properties of a handful of cAMP subcellular compartments, an overall view of the cellular landscape of cAMP nanodomains is missing.
Evaluation of the Clinical Impact of Dapagliflozin Discontinuation as Adjunctive Therapy for Patients With Type 1 Diabetes After Indication Withdrawal: A Two-Center Retrospective Study
Authors: José Ignacio Martínez-Montoro, María José Picón-César, Víctor José Simón-Frapolli, José Luis Pinzón-Martín, Jorge García-Alemán, María Durán-Martínez, Francisco J. Tinahones
Journal: Diabetes Care (2023)

Use of the sodium-glucose cotransporter 2 inhibitor dapagliflozin leads to improvements in glycemic control, weight loss, and decreased insulin requirements in patients with type 1 diabetes (T1D) (1,2).Dapagliflozin was approved by the European Medicines Agency in 2019 as addon therapy to insulin for the treatment of T1D.However, based on the removal of this indication by AstraZeneca, dapagliflozin has not been authorized for this population since October 2021.Although changes in glycemic outcomes and other important clinical variables might be expected after the discontinuation of dapagliflozin following this decision, there are no available data concerning this premise.Thus, in this study, we assessed the clinical impact of dapagliflozin discontinuation in patients with T1D after the withdrawal of this indication.We performed a two-center retrospective cohort study based on the medical records of patients with T1D who received dapagliflozin as adjunctive therapy to insulin.We selected all patients with T1D with follow-up at the
Success After Treatment of Pelvic Organ Prolapse With Surgery or Pessary Remains a Patient-Centered Choice
Authors: Elisa Rodriguez Trowbridge, Gina M. Northington
Journal: JAMA Surgery (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Additional Outcomes and Limitations in the Treatment of Acute Unstable Chest Wall Injuries—Reply
Authors: Niloofar Dehghan, Michael McKee
Journal: JAMA Surgery (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal