tbuckley/cabot-search huggingface dataset:
Patient-physician covenant
Authors: R. Crawshaw
Journal: JAMA (1995)

Medicine is, at its center, a moral enterprise grounded in a covenant of trust. This covenant obliges physicians to be competent and to use their competence in the patient's best interests. Physicians, therefore, are both intellectually and morally obliged to act as advocates for the sick wherever their welfare is threatened and for their health at all times. Today, this covenant of trust is significantly threatened. From within, there is growing legitimation of the physician's materialistic self-interest; from without, for-profit forces press the physician into the role of commercial agent to enhance the profitability of health care organizations. Such distortions of the physician's responsibility degrade the physician-patient relationship that is the central element and structure of clinical care. To capitulate to these alterations of the trust relationship is to significantly alter the physician's role as healer, carer, helper, and advocate for the sick and for the health of all. By
`Seronegative spondarthritis'
Authors: I. Haslock
Journal: Annals of the Rheumatic Diseases (1984)

Royal National Hospital for Rheumatic Diseases we found 2 Schmorl G. Junghanns H. Ile Iiieit ma spine in lien/iltl, 01(1 differences between the seropositive and seronegative disease.2nd American edition translaited aind editcd by E F patients that to some extent paralleled our original
Reproductive toxicology. Theobromine.
Authors: James Lamb, Dushyant Gulati, Harlal Choudhury, Robin Chambers, K Poonacha, P Sabharwal
Journal: Environmental Health Perspectives (1997)

O CH3N HN / N CH3 Theobromine (ThB) is a natural compo- nent in cocoa, cola, and tea that finds pharmaceutical use as a diuretic, cardiac stimulant, vasodilator, and a smooth mus- cle relaxant.It was tested for its effects on reproduction and fertility in Swiss CD-1 mice, using the RACB protocol (Morrissey et al., Fundam Appl Toxicol 13:747-777 [1989]).Data on food and water con- sumptions, body weights, and clinical signs from the dose-range-finding study (Task 1) were used to set exposure concentrations for the continuous cohabitation phase (Task 2) at 0.1, 0.25, and 0.5% weight per volume in feed.Neither feed consumption nor body weights during Task 2 were altered by ThB addition.Based on body weights and feed consumption measures, these exposure levels gave calculated con- sumption estimates of approximately 126, 335, and 630 mg/kg/day.In Task 2, four females died: one control, two middle dose, and one high dose.The variety of postmortem findings and the lack of relationship to dose led to the conclusion that these deaths were not treatment related.Reproductive indices were adversely affected by ThB exposure.The mean num- ber of litters per pair was decreased at the
Editor's Choice
Journal: British Journal of Dermatology (2015)

In utero and early-life chemical exposure and the development of atopic disease and allergyMcFadden and colleagues publish a timely review that seeks to explore why there has been a signifi cant increase in atopic disease and associated allergy in Western societies.In this review, they consider the immunophysiology of T helper cell (Th )2 immune skewing during pregnancy.In particular, they explore the possibility that altered and increased patterns of exposure to certain chemicals have served to accentuate this normal Th 2 skewing and therefore further promote the persistence of a Th 2 bias in neonates.Th ey conclude by proposing that the more marked Th 2 skewing observed in fi rst pregnancy may, at least in part, explain the higher prevalence of atopic disease and allergy in the fi rst born.
Partner bereavement and risk of psoriasis and atopic eczema: cohort studies in the United Kingdom and Denmark
Journal: British Journal of Dermatology (2020)

Stress is commonly quoted as a risk factor for psoriasis and eczema, but there is very little evidence.The aim of this study was to investigate the association between partner death (an extremely stressful life event) and psoriasis or eczema.We conducted cohort studies (which follow research participants over a period of time) using data from the UK Clinical Practice Research Datalink (1997Datalink ( -2017) ) and Danish nationwide registries (1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016) comparing risk of psoriasis and eczema in people whose partners died to people without partner death.The comparison group were matched to each person with partner death by age, sex, county of residence (Denmark), and general practice (UK).We assessed how strong the evidence was that partner death was associated with psoriasis and eczema in the UK and Denmark and then combined findings in both settings.In two cohort studies in general populations in the UK and Denmark, there was no evidence of an increased risk of psoriasis associated with partner bereavement.There was a short-term increased risk of eczema in three years following partner death, which peaked during the first three months.However, there was no evidence of an increased long-term risk of eczema.Acute stress may play a role in triggering the onset of new eczema or relapse of eczema previously in remission.We observed no evidence for increased long-term risk of psoriasis and eczema following bereavement.
ECFMG assessment of clinical competence of graduates of foreign medical schools. Educational Commission for Foreign Medical Graduates
Authors: A. I. Sutnick
Journal: JAMA (1993)

<h3>Objective.</h3> —To develop an assessment of clinical competence of graduates of foreign medical schools and to determine the reliability and validity of the assessment and the feasibility of large-scale administration. <h3>Design.</h3> —The Educational Commission for Foreign Medical Graduates (ECFMG) clinical competence study included (1) clinical encounters with standardized patients to assess history taking, physical examination, and communication skills; (2) laser videodisk pictorials to assess identification and interpretation of diagnostic procedures; (3) written clinical vignettes to assess diagnosis and management skills; and (4) assessment of spoken English. A uniform method of operating the test centers and of training the standardized patients was developed. <h3>Setting.</h3> —Medical schools and their primary teaching hospitals and affiliated hospitals. <h3>Participants.</h3> —Six hundred twenty-four first-year residents, of whom 525 are graduates of foreign medical schools. <h3>Main Outcome Measures.</h3> —Scores, reliability coefficients, validity measures, feasibility of multisite administration, trends of scores over time, and acceptability by examinees. <h3>Results.</h3> —The ECFMG clinical competence assessment was conducted at four geographically separate test centers. Reliability coefficients were high (.85) for the integrated clinical encounter and were in a reasonable range (.71 to.82) for all test components. The assessment adds to the predictability of the residents' performance in the hospital over that of current ECFMG certification examinations. Test security was addressed by demonstrating no consistent pattern of change in scores over testing dates. Virtually all examinees thought the assessment was appropriate. Standardized patients were able to assess spoken English accurately. <h3>Conclusion.</h3> —The feasibility of conducting a reliable and valid test of clinical competence for graduates of foreign medical schools was demonstrated for this test population. (<i>JAMA</i>. 1993;270:1041-1045)
Finger wrinkling after immersion in water.
Journal: BMJ (1980)

cases, although in two female patients this was not obtained until necropsy.There were 19 female and two male patients, the mean age of presentation was 57 9 years, and seven patients (33%) were over the age of 65.These data reveal that in Tayside the annual incidence of primary biliary cirrhosis is 10-6 per million.On 31 December 1979 16 patients with the diagnosis were still alive, revealing the point prevalence as 40 2 per million.The incidence figure is almost twice that found by Dr Triger in Sheffield (5-8 per million), and by other workers in NE England (6-0 per million-as reported at the September
NHS reorganization.
Journal: BMJ (1972)

deaths and it alone licensed the stronger products, as did the United Kingdom, the Republic of Ireland, Australia, and New Zealand.Other countries in which the stronger pre- paration was not used also escaped the increased asthma mortality.Only two countries which marketed it were spared the increase in asthma deaths-the Netherlands and Belgium-and here it is relevant that the preparation was introduced relatively late and sales were low.No signifi- cant relationship was found between propellants and varia- tions in asthma mortality in different countries.This additional information strengthens still further the case for relating the increase in asthma deaths to aerosols and the sympathomimetic drugs they contain.It also under- lines the importance of avoiding excessive use of bronchodi- lator aerosols, particularly of the more concentrated type.Doctors must stress to patients using these drugs that the dose should not be increased in the absence of a normal response.
Abdominal Angiography
Authors: James J. Pollard, Robert A. Nebesar
Journal: New England Journal of Medicine (1968)

ANGIOGRAPHY OF THE PANCREASAngiography of the pancreas has been considered promising as a method of radiologic visualization of this organ.171 172 173 However, there is varying enthusiasm among angioradiologists regarding its merit. No large series of controlled observations has been published, and only a few reports have made statements of preoperative accuracy.The variable vascular anatomy of the pancreas is of considerable importance, for it influences the accuracy of angiography as well as having a bearing on technical aspects. Anyone attempting pancreatic angiography and its interpretation must be thoroughly aware of these anatomic variations.116, 174 Owing to the multiple sites of origin . . .
First Protease Inhibitor Approved for Treatment of HIV
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply:
Authors: Maria Stepanova, Zobair M. Younossi
Journal: Hepatology (2011)

We appreciate the interest and comments offered by Dai et al.1 concerning our recently published article about health insurance coverage for patients with hepatitis C virus (HCV).2 We believe that health insurance coverage is among the most important factors influencing access to care for patients with HCV. We emphasize that in addition to the cost of medication, costs associated with routine management of HCV and costs associated with the complications of HCV-related cirrhosis, such as decompensated cirrhosis, hepatocellular carcinoma, and liver transplantation should be considered.3 Although we agree that the cost of HCV treatment (medication, monitoring, and adverse effect management) is important, the costs associated with achieving the desired outcome are critical. Such costs are measured by the cost (in dollars) per quality-adjusted life years gained.4, 5 This type of cost-effectiveness analysis includes treatment costs as well as other direct and indirect costs that can potentially be avoided (e.g., complications of cirrhosis, liver transplantation) by achieving a cure as a consequence of treatment. This type of cost-effectiveness analysis is influenced by the cost of treatment, the efficacy rates for anti-HCV treatment, and health utilities or patients' quality of life.6 Therefore, as we develop better anti-HCV treatments with higher efficacy rates (e.g., direct-acting antivirals) and increasingly adopt a personalized medicine approach to HCV treatment (e.g., pretreatment interleukin-28 genotyping, shorter treatment course of treatment for patients with rapid virologic response), the cost-effectiveness profile of HCV treatment will continue to improve. Our article addresses only two aspects of HCV care that can negatively impact patients' access to care: health insurance coverage and candidacy for treatment. Although some health conditions are absolute contraindications and may represent a fixed barrier to treatment of HCV, other barriers to treatment can be corrected. These include relative contraindications to treatment that may be managed more optimally over time so that these patients become treatment candidates. An enormously positive impact in removing barriers to care for HCV patients in the United States can be achieved by providing universal health insurance coverage for these patients. We believe that as we improve the efficacy and the side effect profile of the next generation of anti-HCV regimens, HCV treatment will become increasingly cost-effective. In this context, universal health insurance coverage would allow us to provide cutting-edge and personalized care to a large number of HCV patients. Maria Stepanova Ph.D.* , Zobair M. Younossi M.D., M.P.H.* , * Center for Liver Diseases at Inova Fairfax Hospital, Inova Health System Falls Church, VA, Betty and Guy Beatty Center for Integrated Research, Inova Health System Falls Church, VA.
The Seventeenth Veterans Administration–Armed Forces Conference on the Chemotherapy of Tuberculosis
Authors: Emil Rothstein
Journal: New England Journal of Medicine (1958)

APPROXIMATELY twelve years ago, when streptomycin first became available for the treatment of tuberculosis in man, Dr. John B. Barnwell, then director of the Tuberculosis Service of the Veterans Administration, and his associate, Dr. Arthur Meeker Walker, suggested that the Veterans Administration tuberculosis hospitals using this antibiotic do so through the mechanism of a nationwide Cooperative study group. Its purpose would be to learn, while this powerful newly discovered antituberculous agent was being used, as much as possible about dosage, therapeutic effect, toxicity and the best methods and optimum duration of its administration. From rather small beginnings a Cooperative study . . .
Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis
Authors: Li Li, Kiran Kumar Naidu Guturi, Brandon Gautreau, Parasvi S. Patel, Amine Saad, Mayako Morii, Francesca Mateo, Luis Palomero, Haithem Barbour, Antonio Gomez, Deborah Ng, Max Kotlyar, Chiara Pastrello, Hartland W. Jackson, Rama Khokha, Igor Jurisica, El Bachir Affar, Brian Raught, Otto Sanchez, Moulay Alaoui-Jamali, Miguel A. Pujana, Anne Hakem, Razq Hakem
Journal: Journal of Clinical Investigation (2021)

During the preparation of this manuscript, tumor-free survival data rather than mammary tumor-free survival data were inadvertently included in Figure 1A.The correct figure panel for mammary tumor-free survival is below.The authors regret the error.
Tools available for health care providers whose patients are at risk for domestic violence
Authors: T. Randall
Journal: JAMA (1991)

HEALTH CARE providers may be the first and only professionals in a position to recognize violence in their patients' lives. Physicians are advised to routinely discuss the problem of domestic violence with their female patients and make available written material with resource information. <h3>Resources for Patients</h3> The Michigan Coalition Against Domestic Violence provides information packets to health care providers nationwide that include brochures and stickers for use in the office. Physicians who use these materials say they cannot keep enough on hand. All the materials may be reproduced. (Write the Michigan Coalition Against Domestic Violence, PO Box 463100, Mount Clemens, MI 48046, or telephone (313) 954-1180.) The best place to display the brochures is in the examination room, and not the lobby, says Sherrie Eisele, advocate/volunteer coordinator for Woman-Kind. If the brochures are in the lobby, Eisele explains, the woman has to "walk across the room and pick up a
Acute Myeloid Leukemia
Authors: Carolyn J. Hildreth
Journal: JAMA (2010)

Acute Myeloid LeukemiaL eukemia is a cancer of the white blood cells that spreads throughout the bloodstream and may affect many organs.It originates in the bone marrow (spongy center of bones), which is where all blood cells are developed before being released into the bloodstream.Leukemia is classified based on the type of abnormal white blood cell and by how rapidly these cells leave the bone marrow and enter the bloodstream.Acute myeloid leukemia (AML) is the most common type of leukemia that affects adults.The December 22/29, 2010, issue of JAMA includes an article about the association between genetic characteristics of leukemia cells and outcomes of the disease.This Patient Page is based on one published in the June 10, 2009, issue of JAMA.
UPSETTING IMMUNOLOGIC TENETS
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Herpetic Whitlow
Authors: Kensuke Shoji, Akihiko Saitoh
Journal: New England Journal of Medicine (2018)

A 1-year-old girl was admitted to the hospital with 4 days of fever, erythema, and swelling of a finger. The analysis of an oral lesion was positive for herpes simplex virus type 1, confirming a diagnosis of herpetic whitlow.
The Story of Rodman Heath, or Mugwumps by One of Them.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A NEW OBSERVATION ON THE MECHANISM OF HYPERSENSITIVENESS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transbronchial lung biopsy in the compromised host
Authors: N. T. Feldman
Journal: JAMA (1977)

Thirty-eight immunocompromised patients underwent transbronchial lung biopsy via the fiberoptic bronchoscope as part of a diagnostic evaluation for fever and roentgenographic evidence of a new pulmonary infiltrate. Diagnostic information was obtained from lung biopsy in 29 patients (76%), with infection accounting for ten cases and a nonspecific interstitial pneumonitis in 13 patients. Concomitant bronchial brushings were diagnostic in only three patients (all with infections). Diffuse roentgenographic infiltrates were especially amenable to bronchoscopic lung biopsy diagnosis (84%), while in localized infiltrates, there was only a 43% diagnostic yield. Although thrombocytopenia and hypoxemia were common in these patients, morbidity was low (four patients had pneumothoraces with no noteworthy bleeding) and there were no deaths resulting from this procedure. Prebiopsy platelet transfusions were used in five patients with severe thrombocytopenia (platelet count, &lt; 50,000/cu mm). The diagnostic efficiency and low morbidity associated with transbronchial lung biopsy indicate that this procedure can safely play a role in the evaluation of pneumonia in the compromised host. (<i>JAMA</i>238:1377-1379, 1977)
Full-Impact Medicine
Authors: Matt Mumber
Journal: Journal of Clinical Oncology (2001)

Article Tools SPECIAL DEPARTMENTS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2001.19.17.3793 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11533108 Full-Impact Medicine Matt MumberxMatt MumberSearch for articles by this author Show More InterCommunity Cancer Center, Rome, GA https://doi.org/10.1200/JCO.2001.19.17.3793 First Page Full Text PDF Figures and Tables © 2001 by American Society of Clinical Oncology