tbuckley/cabot-search huggingface dataset:
Changing Congestive Heart Failure Incidence in an Older Population, 1970-74 and 1990-94.
Authors: William H Barker, William Getchell, John Mullooly, Terry Kimes
Journal: Circulation (2001)

P45 Congestive heart failure (CHF) mortality rates have increased dramatically in recent years, particulary among the elderly, but little is known about CHF incidence changes. This study compares CHF incidence between 1970-74 and 1990-94 in a large well-defined population of over 30,000 persons &gt;65 y/o with access to complete medical records. Using Framingham Heart Study (FHS) criteria for confirming CHF we identified 387 and 1555 confirmed cases in the respective periods. We observed unchanging incidence rates of 7.6 and 7.9, and increasing incidence from 15.1 to 18.7 and 27.8 to 42.4 cases per 1000 person-years among persons 65-74, 75-84, and 85+ years old, respectively. In both time periods, 21% of potential cases were unconfirmed by FHS criteria. Onset of confirmed CHF occured as an outpatient in 16% and 22% of cases in the respective periods. Profiles of FHS major and minor diagnostic criteria were very similar for cases in the two timed periods. This study documents significant increase in CHF incidence among old-old(&gt;75y/o) but not young old (65-74). Possible explanations are under study.
Abstract DDT01-01: BI 905677: A first-in-class LRP5/6 antagonist targeting Wnt-driven proliferation and immune escape
Authors: Vittoria Zinzalla, Barbara Drobits-Handl, Alexander Savchenko, Jörg Rinnenthal, Markus Johann Bauer, Michael Sanderson, Sophia Maria Blake, Norbert Schweifer, Robert Gerhardus Jacob Vries, Hans Clevers, Norbert Kraut
Journal: Cancer Research (2019)

Abstract Aberrant Wnt/β-catenin signalling has been shown to play a key role in tumorigenesis and resistance to immunotherapy in several tumor indications. Wnt ligand-mediated signals are transduced by two distinct receptor types, the serpentine receptor Frizzled (FZD) and the closely related single-span transmembrane proteins LRP5 and LRP6. Formation of the FZD-Wnt-LRP5/6 trimeric complex induces phosphorylation of LRP5 or LRP6 intracellular domains leading to inactivation of the β-catenin degradation complex, allowing stabilized β-catenin to enter the nucleus, bind to the TCF transcription factors, and act as a transcriptional activator of Wnt target genes. We have developed a first-in-class LRP5/6 antagonist, a bi-paratopic antibody comprising two modules binding to distinct epitopes of LRP5 (or LRP6). BI 905677 is a highly potent blocker of signalling induced by the Wnt family of ligands and shows anti-tumor activity in cancer models harbouring genomic alterations in upstream regulators of the Wnt pathway, such as RNF43 mutations or RSPO fusions. Furthermore, BI 905677 in combination with an anti-PD-1 immune checkpoint inhibitor induces dendritic cell activation and T cell infiltration in tumor tissues leading to complete responses in syngeneic tumor models. A Phase I clinical trial is underway in patients with advanced cancer to evaluate safety, tolerability, pharmacokinetic and pharmacodynamic properties, and efficacy of BI 905677 (NCT03604445). Citation Format: Vittoria Zinzalla, Barbara Drobits-Handl, Alexander Savchenko, Jörg Rinnenthal, Markus Johann Bauer, Michael Sanderson, Sophia Maria Blake, Norbert Schweifer, Robert Gerhardus Jacob Vries, Hans Clevers, Norbert Kraut. BI 905677: A first-in-class LRP5/6 antagonist targeting Wnt-driven proliferation and immune escape [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr DDT01-01.
Medical Complications During Pregnancy
Authors: John A. Morris
Journal: JAMA (1977)

In the past decade, I have been afforded the unique opportunity of reviewing a number of new textbooks (or revised editions of older texts) that focus on the "medical complications of pregnancy." My reference standard for many years, no longer published, was the text edited by Guttmacher, from Mt Sinai Hospital, New York. I believe that a new standard of reference has now appeared in the professional book market: The Yale School of Medicine text. As noted in the preface by the editors, all 18 contributors to the volume were, at one time or other, associated with Yale. Most still are. The book is composed of 22 reviews written by authors noted for their contributions in the field. These reviews are surprisingly generous in their appraisal of the current state of the art and do not reflect any particular provincial sentiment. There is little evidence of aging in any of
Abstract 17200: Blood Alcohol in Victims of Sudden Cardiac Death in Northern Finland
Authors: Juha Perkiomaki, Eeva Hookana, Kari Kaikkonen, Juhani Junttila, Marja-Leena Kortelainen, Heikki Huikuri
Journal: Circulation (2015)

Background: Momentary intake of large quantity of alcohol provokes ventricular ectopic activity increasing electrical instability. However, data on the prevalence of alcohol intake prior to a sudden cardiac death (SCD) event are limited. Methods: Victims of unexpected SCD (n=2,363, age 61±12 years, males 1,940 (82%)) included in the Finnish study of genotype and phenotype profiles of SCD (FINGESTURE) had a thorough interview of family members, medico-legal autopsy and determination of blood alcohol concentration. Because of the Finnish law, all unexpected deaths undergo medico-legal autopsy. Patients, who were admitted to a hospital due to an acute myocardial infarction (AMI) (n=128, age 63±10 years, males 100 (78%)) served as controls. Results: Based on autopsy findings, 1,691 of these victims had ischemic heart disease and were included in the present analysis. A total of 646 (38%) SCD victims with ischemic heart disease had a blood ethanol concentration above 0‰. Of these victims with blood alcohol test positive, 41% (n=264) had blood ethanol concentration ≥ 1.5‰ and 56% (n=362) ≥ 1‰. Male SCD victims had more frequently alcohol in blood than the females (40% vs. 27%, p&lt;0.001, respectively). None of the controls, who gave a consent for the blood ethanol concentration determination (n=88), had alcohol in blood. Of the controls, 40 (31%) declined to participate in the study and give the consent for blood alcohol testing. Conclusion: Almost 4/10 of the victims of unexpected SCD have evidence of alcohol intake before the fatal event in the Northern Finland autopsy population.
Patient Pretenders Weave Tangled "Web" of Deceit
Authors: J. Stephenson
Journal: JAMA (1998)

IN a New Yorker cartoon that appeared in 1993, one cyberspace-cruising dog tells his canine pal, "On the Internet, nobody knows you're a dog." The point, as anyone who has spent much time online knows all too well, is that the medium is unusually conducive to deception.
Manpower issues for a surgical specialty: the impact of oversupply
Authors: B. J. Bailey
Journal: JAMA (1985)

Physician manpower is an issue that deserves and is receiving considerable attention at present. The number of practicing physicians has increased by approximately one third during the past decade, and it is projected that it will increase in approximately the same amount during the next ten years. While most of us find drastic change upsetting and tend to resist change, the consequences of this dramatic event are fundamental to the manner in which all of us will conduct our professional activities for the remainder of our careers. Two facts seem clear: first, this is a complex area and does not lend itself to oversimplification or overgeneralization, and, second, there is likely to be considerable difference in the impact of this general manpower growth from one specialty to another. For the sake of further discussion, let us make the following two assumptions concerning the specialty of Otolaryngology— Head and Neck Surgery:
A randomized trial comparing transjugular intrahepatic portosystemic stent-shunt with variceal band ligation in the prevention of rebleeding from esophageal varices.
Authors: R Jalan
Journal: Hepatology (1997)

The aim of this study was to compare transjugular intrahepatic portosystemic stent-shunt (TIPSS) with variceal band ligation (VBL) in the secondary prophylaxis of esophageal variceal hemorrhage in patients with cirrhosis. Fifty-eight patients with cirrhosis who presented with the first episode of esophageal variceal hemorrhage were randomized to TIPSS (31) or VBL (27), 24 hours after control of bleeding. Shunt function was assessed after 1 month and then at 6 monthly intervals thereafter. VBL was performed weekly until variceal eradication, and then at 3 months, 6 months, and yearly thereafter. Mean follow-up in the TIPSS group was 15.7 (+/-10.2) months; in the VBL group, it was 16.8 (+/-10.9) months. Results for rebleeding and mortality were analyzed on an intention-to-treat basis and using the Kaplan-Meier method. The frequency and the severity of variceal rebleeding was significantly lower in the TIPSS group (9.8%), compared with the VBL group (51.9%) (P < .0006). Although mortality rates were not significantly different, 8 of the patients who rebled in the VBL group required TIPSS therapy for uncontrolled bleeding. No significant differences were found in the frequency of other complications such as encephalopathy and sepsis. Patients in the VBL group required significantly greater time in the intensive care unit during the period of this study (<0.03). The total direct cost of treatment incurred was pound sterling 1,373 ($2,200) per patient, the cost being less in the patients treated with TIPSS compared with VBL. The results of this study show that TIPSS is superior to VBL for the secondary prophylaxis of variceal hemorrhage in patients with cirrhosis. (Hepatology 1997 Nov;26(5):1115-22)
Outcomes of community and prison-based hepatitis C treatment using an eHealth model of care
Authors: James Haridy, Guru Iyngkaran, Amanda Nicoll, Kate Muller, Zina Valaydon, Jane Davies, Mark Wilson, Anton Colman, Jeyamani Ramachandran, Renjy Nelson, Rosalie Altus, Sally Watkinson, Jeff Stewart, Daniel Pronk, Cameron Edgell, Danny Liew, Edmund Tse
Journal: Journal of Hepatology (2020)
Atlas of Selected Cases of Pathological Anatomy
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RAILROAD NOTICE.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cover Image, Volume 38, Issue 4
Authors: Kenneth A. Jacobson, Stefania Merighi, Katia Varani, Pier Andrea Borea, Stefania Baraldi, Mojgan Aghazadeh Tabrizi, Romeo Romagnoli, Pier Giovanni Baraldi, Antonella Ciancetta, Dilip K. Tosh, Zhan‐Guo Gao, Stefania Gessi
Journal: Medicinal Research Reviews (2018)

On the cover: The cover image, by Kenneth A. Jacobson et al., is based on the Review Article A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy, https://doi.org/10.1002/med.21456.
Quarterly Table Reporting Alcohol Involvement in Fatal Motor Vehicle Crashes
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Toxicity of Inhaled Methyl Isocyanate in F344/N Rats and B6C3F1 Mice. II. Repeated Exposure and Recovery Studies
Authors: John R. Bucher, Bhola N. Gupta, Morrow Thompson, Bernard Adkins, Bernard A. Schwetz
Journal: Environmental Health Perspectives (1987)

F344/N rats and B6C3F1 mice were exposed to 0, 1, 3, or 6 ppm methyl isocyanate by inhalation for 6 hr on 4 consecutive days. Deaths of rats were observed following 3 ppm exposures, and mice died after exposures to 6 ppm. Deaths appeared to be related to severe respiratory distress. Survivors in high dose groups lost weight initially, then gained weight at rates equal to controls throughout a 91-day recovery period. Lung weights increased significantly in male and female rats exposed to 3 ppm, but no persistent changes in brain, kidney, thymus, spleen, liver, or testis weights were seen in either mice or rats. Blood and serum from male and female rats were taken for clinical pathology and hematology assessments on day 7 of postexposure, the day prior to the first observed deaths of these animals. No changes or only slight changes were seen in measures of serum alanine aminotransferase, sorbitol dehydrogenase, alkaline phosphatase, or in blood and brain cholinesterase activities. However, serum creatine kinase increased with dose in both males and females. Blood urea nitrogen, creatinine, and methemoglobin were unchanged. No changes were seen in counts of red blood cells or platelets, or in red cell indices. Hemoglobin concentrations and hematocrits were slightly elevated. No changes were noted in absolute leukocyte counts, but counts of segmented neutrophils increased and lymphocytes decreased.(ABSTRACT TRUNCATED AT 250 WORDS)
Urinary tract infections in young adult women caused by Staphylococcus saprophyticus
Authors: R. H. Latham
Journal: JAMA (1983)

We evaluated and compared 81 urinary tract infections (UTIs) with<i>Staphylococcus saprophyticus</i>occurring in 72 college women with<i>Escherichia coli</i>UTIs. During the 14-month study period,<i>S saprophyticus</i>was the second most common cause of UTIs, accounting for 11% of the total.<i>Staphylococcus saprophyticus</i>infections occurred more frequently during the late summer and early fall. Age, history of previous UTI, signs and symptoms of infection, and findings on urinalysis were similar in patients with<i>S saprophyticus</i>and<i>E coli</i>infections. Nine (41%) of 22<i>S saprophyticus</i>infections were localized to the upper urinary tract by the antibody-coated bacteria technique compared with 18 (16%) of 115 infections with<i>E coli</i>(<i>P</i>=.01). Rectal, vaginal, and urethral colonization with<i>S saprophyticus</i>was associated with UTI caused by these organisms, suggesting that their pathogenesis resembles that of<i>E coli</i>UTIs. In vitro susceptibility testing showed almost uniform sensitivity of<i>S saprophyticus</i>to most antimicrobials used to treat UTIs, but recurrent infections occurred in six of the 72 women despite adequate therapy. Physicians and microbiologists must be aware that<i>S saprophyticus</i>is an important cause of UTIs in young women. (<i>JAMA</i>1983;250:3063-3066)
FDA May Get Welcome New Funds in Its Budget
Authors: C. Marwick
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Drug Legalization, Harm Reduction, and Drug Policy
Authors: Otto S. Baum
Journal: Annals of Internal Medicine (1996)

Letters15 April 1996Drug Legalization, Harm Reduction, and Drug PolicyOtto S. Baum, MDOtto S. Baum, MDWest Orange, NJ 07052Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-8-199604150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The article by Dupont and Voth [1] and the editorial by Dr. Musto [2] fail to address the question of crime related to the drug trade, that is, violent acts committed to obtain money for the purchase of drugs. If addicts were given drugs from the huge stores of seized cocaine and heroin and were given sterile syringes and needles, the profit motive would disappear, the crime rate would be reduced, and the rate of transmission of the human immunodeficiency virus and other pathogens by injection would be decreased. Legalization could be aided by appropriate education of ...References1. DuPont RL, Voth EA. Drug legalization, harm reduction, and drug policy. Ann Intern Med. 1995; 123:461-5. Google Scholar2. Musto DF. Perception and regulation of drug use: the rise and fall of the tide [Editorial]. Ann Intern Med. 1995; 123:468-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: West Orange, NJ 07052 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1996Volume 124, Issue 8Page: 776KeywordsAddictsCocaineCrimeDrug policyDrugsHIVHeroinPathogens ePublished: 15 August 2000 Issue Published: 15 April 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Reproductive Toxins and Alligator Abnormalities at Lake Apopka, Florida
Authors: Jan C. Semenza, Paige E. Tolbert, Carol H. Rubin, Louis J. Guillette, Richard J. Jackson
Journal: Environmental Health Perspectives (1997)

The alligator population at Lake Apopka in central Florida declined dramatically between 1980 and 1987. Endocrine-disrupting chemicals and specifically DDT metabolites have been implicated in the alligators' reproductive failure. The DDT metabolite hypothesis is based largely on the observation of elevated concentrations of p,p-DDE and p,p-DDD in alligator eggs obtained from Lake Apopka in 1984 and 1985. In the following commentary, we draw attention to two nematocides that are established reproductive toxins in humans, dibromochloropropane (DBCP) and ethylene dibromide (EDB), which could also have played a role in the reproductive failure observed in alligators from Lake Apopka in the early 1980s.