tbuckley/cabot-search huggingface dataset:
Epidemiological and clinical profile of HDV infected people in care in Italy: interim analysis from the ongoing PITER cohort
Authors: Loreta Kondili, Maria Elena Tosti, Maria Giovanna Quaranta, Alessia Ciancio, Vincenzo Messina, Giuseppina Brancaccio, Maurizia Brunetto, Mario Capasso, Valerio Rosato, Irene Cacciola, Luisa Pasulo, Teresa Santantonio, Carmine Coppola, Elisa Biliotti, Francesco Barbaro, Marco Massari, Nicola Coppola, Alberto Ferrarese, Francesco Paolo Russo, Vito Di Marco, Aldo Marrone, Simona Schivazappa, Alessandro Federico, Pierluigi Blanc, Alba Rocco, Giulia Morsica, Donatella Ieluzzi, Fabio Conti, Martina De Siena, Maria Grazia Bavetta, Michele Milella, Ivan Gentile, Carmen Porcu, Liliana Chemello, Monia Maracci, Anna Linda Zignego, Leonardo Baiocchi, Ivana Rita Maida, Barbara Coco
Journal: Journal of Hepatology (2023)
Selective inhibition of human β-catenin DNA transactivation activity using splice switching oligonucleotides for an improved therapeutic window in treating hepatocellular carcinoma
Authors: Jin Hong, Vera Huang, Laxman Eltepu, Hua Tan, Vivek Rajwanshi, Aneerban Bhattacharya, Elen Rosler, Kang Hyunsoon, Min Luo, Saul Montero, John Cortez, Dana Cho, David Smith, Lawrence Blatt, Julian Symons, Leonid Beigelman
Journal: Journal of Hepatology (2023)
Survival outcomes of hepatocellular carcinoma after yttrium-90 selective internal radiation therapy in an Asian population stratified by tumour volume and distribution
Authors: Kaina Chen, Fiona Ni Ni Moe, Aaron Kian Ti Tong, David Chee Eng Ng, Richard Hoau Gong Lo, Apoorva Gogna, Sean Xuexian Yan, Sue Ping Thang, Kelvin Siu Hoong Loke, Karaddi Venkatanarasimha Nanda Kumar, Hian Liang Huang, Chow Wei Too, Weng Yan Ng, Marjorie Hoang, Pierce Chow
Journal: Journal of Hepatology (2023)
Glycated hemoglobin as an independent predictor of hepatocyte ballooning in non-alcoholic steatohepatitis: combined data from multiple clinical trials including more than 5000 patients (in collaboration with NAIL-NIT consortium)
Authors: Stephen Harrison, Julie Dubourg, Sophie Jeannin Megnien, Jörn Schattenberg, Vlad Ratziu, Michael Charlton, Naim Alkhouri, Mazen Noureddin
Journal: Journal of Hepatology (2023)
Genetic risk factors for NAFLD and clinically significant fibrosis in persons living with HIV
Authors: Eduardo Vilar Gomez, Samer Gawrieh, Tiebing Liang, Jordan Lake, Susanna Naggie, Tinsay Woreta, Jennifer Price, Richard Sterling, Sonya Heath, Holly King, Laura Wilson, James Tonascia, Meena Bansal, Kathleen Corey, Rohit Loomba, Mark S. Sulkowski, Naga Chalasani
Journal: Journal of Hepatology (2023)
Use of magnetic resonance elastography for accurate staging of liver fibrosis in children with autoimmune hepatitis
Authors: Wojciech Janczyk, Jędrzej Sarnecki, Piotr Pawliszak, Paulina Opyrchał, Kamil Janowski, Diana Kamińska, Małgorzata Woźniak, Wieslawa Grajkowska, Maciej Pronicki, Elżbieta Jurkiewicz, Piotr Socha
Journal: Journal of Hepatology (2023)
Cancer incidence and survival in HFE hemochromatosis-A population-based cohort study
Authors: Benedikt Schaefer, Lorenz Michael Pammer, Bernhard Pfeifer, Sabrina Neururer, Maria Troppmair, Marlene Panzer, Sonja Wagner, Elke Pertler, Christian Gieger, Florian Kronenberg, Claudia Lamina, Herbert Tilg, Heinz Zoller
Journal: Journal of Hepatology (2023)
Overcoming barriers to care for Delta infected patients
Authors: Ariadna Bono, Ângela Carvalho-Gomes, Maria Dolores Gómez Ruiz, Susana Sabater Vidal, Juan Carlos, Rodríguez Díaz, Helena Hernàndez-Èvole, Antonio David Palau Canos, Ana Forés, Maria Rodriguez, Maria L Molina, Sonia Pascual, Martin Prieto, Marina Berenguer
Journal: Journal of Hepatology (2023)
Impact of the metabolic profile on the response to ursodeoxycholic acid in patients with primary biliary cholangitis: results of the ColHai registry
Authors: Alvaro Diaz Gonzalez, Andrea González Pascual, Judith Gómez-Camarero, Elena Gómez Domínguez, Maria Carlota Londoño, Mercedes Vergara Gómez, Javier Ampuero, Javier Martinez, Diana Horta, Adolgo Gallego, Javier Salmerón, Montserrat García-Retortillo, Rosa M. Morillas, Raul J. Andrade, Juan Turnes, Moises Diago, Ismael El Hajra Martínez, Merce Roget Alemany, Manuel Hernández Guerra, Nerea Quintans, Margarita Sala, Nuria Dominguez, Ana Arencibia Almeida, Javier Crespo, Ana Barreira, Magdalena Salcedo, Mar Riveiro Barciela
Journal: Journal of Hepatology (2023)
Neuroscience or stealth marketing? Experts alarmed at free Barbies for primary schools to teach social skills
Authors: Hristio Boytchev
Journal: BMJ (2023)

Free dolls were given to 700 UK schools as part of Mattel’s “Barbie School of Friendship” programme, which the company says was based on neuroscience research, but critics are worried about overt marketing. <b>Hristio Boytchev</b> reports
Add-on benefits of AFP-L3, PIVKA-II and GALAD score to ultrasound plus AFP for surveillance of hepatocellular carcinoma
Authors: Supot Nimanong, Tawesak Tanwandee, Punchai Charatcharoenwitthaya, Siwaporn Chainuvati, Watcharasak Chotiyaputta
Journal: Journal of Hepatology (2023)
Peri-procedural complications in people with primary sclerosing cholangitis undergoing endoscopic retrograde cholangiopancreatography-evaluating a high-volume programme
Authors: Kristel Leung, Yasi Xiao, Jeff Mosko, Aliya Gulamhusein, Bettina Hansen, Gary May, Gideon Hirschfield
Journal: Journal of Hepatology (2023)
Assessment of silent coronary artery disease with functional and anatomic tests in liver transplantation: analysis of the diagnostic and prognostic capacity of a risk-adapted protocol
Authors: Giulia Pagano, Pablo Ruiz, Jordi Colmenero, Sergio Rodriguez-Tajes, Judit Mestres, Julia Martinez-Ocon, Salvatore Brugaletta, Gonzalo Crespo
Journal: Journal of Hepatology (2023)
Effects of tetrathiomolybdate, trientine, and penicillamine on intestinal copper uptake: a randomized placebo-controlled 64Cu PET/CT study
Authors: Frederik Teicher Kirk, Ditte Emilie Munk, Eugene Scott Swenson, Adam Quicquaro, Mikkel Holm Vendelbo, Michael Schilsky, Peter Ott, Thomas Damgaard Sandahl
Journal: Journal of Hepatology (2023)
Management of varices but not anticoagulation is associated with improved outcome in patients with hepatocellular carcinoma and macrovascular tumour invasion
Authors: Lorenz Balcar, Arpad Mrekva, Bernhard Scheiner, Katharina Pomej, Tobias Meischl, Mattias Mandorfer, Thomas Reiberger, Michael Trauner, Dietmar Tamandl, Matthias Pinter
Journal: Journal of Hepatology (2023)
Late presentation of chronic hepatitis C for care in Georgia: data from the national hepatitis C elimination program, 2016–2021
Authors: Tengiz Tsertsvadze, Nikoloz Chkhartishvili, Shaun Shadaker, Akaki Abutidze, Lali Sharvadze, Amiran Gamkrelidze, Irina Tskhomelidze, Senad Handanagic, Tamar Gabunia
Journal: Journal of Hepatology (2023)
Loss of mucosal tolerance to glycoprotein 2 isoform 1 is a novel diagnostic biomarker for cholangiocarcinoma without underlying PSC
Authors: Chang-sheng Xia, Marcin Krawczyk, Chun Di, Łukasz Krupa, Beata Kruk, Wacław Hołówko, Piotr Milkiewicz, Huizhang Bao, Xiao He, Daming Liu, Chunhong Fan, Abdullah Nasser, Steffi Lopens, Peter Schierack, Dirk Roggenbuck, Yudong Liu
Journal: Journal of Hepatology (2023)
Altered levels of secondary bile acids in enterohepatic circulation impairs liver regeneration in a rat model of partial hepatectomy
Authors: Impreet Kaur, Rajnish Tiwari, Pinky Juneja, Ashwini Vasudevan, Akash Kumar Mourya, Michael Trauner, Shiv Kumar Sarin, Dinesh Mani Tripathi, Savneet Kaur
Journal: Journal of Hepatology (2023)
Constitutive signaling from an engineered IL-21 receptor programs long-lived effector TCR-T cells for HCC therapy
Authors: Wei Zhu, Zhiming Zhang, Jinzhang Chen, Xiaolan Chen, Xuan Huang, Weikang Xu, Xuan Yi, Xinyu Lu, Sha Wu, Yongyin Li, Jinlin Hou
Journal: Journal of Hepatology (2023)
Chromosome engineering and CRISPR-Cas9 viability screening reveals increased metastatic capacity targetable by patient-specific synthetic lethality
Authors: Thorben Huth, Emely Dreher, Steffen Lemke, Sarah Fritzsche, Raisatun Sugiyanto, Darko Castven, David Ibberson, Carsten Sticht, Eva Eiteneuer, Anna Jauch, Stefan Pusch, Thomas Albrecht, Benjamin Goeppert, Jens Marquardt, Sven Nahnsen, Peter Schirmacher, Stephanie Roessler
Journal: Journal of Hepatology (2023)
Hepatic alterations in COVID-19: a comparative autopsy study
Authors: Sigurd Lax, Kristijan Skok, Peter Zechner, Stephan Aberle, Ute Bargfrieder, Claudia Grosse, Helmut Salzer, Thomas Zlamal, Lisa Setaffy, Harald Kessler, Hans-Peter Dienes, Michael Trauner
Journal: Journal of Hepatology (2023)
Clinical characteristics and phase transition of chronic hepatitis B patients with HBeAg and anti-HBe coexistence
Authors: Ruifei Xue, Jian Wang, Jie Zhan, Zhiyi Zhang, Suling Jiang, Juan Xia, Weimao Ding, Jie Li, Rui Huang, Chao Wu
Journal: Journal of Hepatology (2023)
Development of metabolic disorders in transplant recipients
Authors: Gizem Erdemir, Hale Gokcan, Ayşegül Gürsoy Çoruh, Basak Gulpinar, Zeynep Melekoğlu Ellik, Mesut Gümüşsoy, Serkan Duman, Emin Bodakçi, Ramazan Idilman
Journal: Journal of Hepatology (2023)
Risk of death, liver transplant or hepatic decompensation in primary biliary cholangitis increases with increased duration and degree beyond established clinical thresholds for hepatic biomarkers and fibrosis scores
Authors: Kris Kowdley, Tracy Mayne, Erik Ness, Darren Wheeler, Radhika Nair, Nicholas Procaccini, Leona Bessonova, Joanna MacEwan, Alina Levine, Gideon Hirschfield
Journal: Journal of Hepatology (2023)
Novel serum markers of cccDNA transcriptional activity-HBcrAg and pre-genomic RNA and CXCL10 pro-inflammatory chemokine levels can reduce uncertainty of HBeAg-negative chronic hepatitis B phases
Authors: Ivana Carey, Mark Anderson, James Lok, Christiana Moigboi, Bo Wang, Gavin Cloherty, Geoffrey Dusheiko, Kosh Agarwal
Journal: Journal of Hepatology (2023)
RBCK1 promotes cancer stemness and sorafenib resistance by restoring Numb/Notch1 axis independently of its ubiquitin ligase activity in hepatocellular carcinoma
Authors: Peng Chen, Zheyu Dong, Jian Ruan, Junling Chen, Yuxin Zhou, Xinxin Liao, Yongfa Tan, Chuanjiang Li, Yuhao Wang, Huajin Pang, Chunhua Wen, Yuchuan Jiang, Xiaoqing Li, Bo Li, Aihetaimu Aimaier, Li Lin, jian sun, Jiajie Hou, Libo Tang, Jinlin Hou, Yongyin Li
Journal: Journal of Hepatology (2023)
Low coverage of hepatitis D virus testing in individuals with HIV and HBV in the Netherlands: a retrospective, cross-sectional and longitudinal study
Authors: Anders Boyd, Colette Smit, Annemiek Van der Eijk, Hans Zaaijer, Bart Rijnders, Berend van Welzen, Marc Classen, Katalin Pogany, Theodora de Vries-Sluijs, Eline Op de Coul, Marc van der Valk
Journal: Journal of Hepatology (2023)
A potent human PD-L1 siRNA leads to significant reduction of AAV-HBV infected hepatocytes via immune activation in human PD-1/PD-L1 double knock in mice
Authors: Jin Hong, Dawei Cai, Saul Montero, Hua Tan, Vivek Rajwanshi, Aneerban Bhattacharya, Kang Hyunsoon, Min Luo, Megan Fitzgerald, David Smith, Lawrence Blatt, Julian Symons, Leonid Beigelman
Journal: Journal of Hepatology (2023)
The liver worsens in non-alcoholic fatty liver disease patients as diabetes mellitus worsens and lasts longer
Authors: Zülal İstemihan, Fatih Bektaş, Ali Emre Bardak, Cansu Kızıltaş, Gamze Kemeç, Ziya Imanov, Volkan Senkal, Kanan Nuriyev, Aynure Rüstemzade, Sezen Genç, Hülya Hacışahinoğulları, Kubilay Karşıdağ, Bilger Çavuş, Aslı Çifcibaşı Örmeci, Filiz Akyuz, Kadir Demir, Fatih Besisik, Sabahattin Kaymakoglu
Journal: Journal of Hepatology (2023)
Global burden of common cancers attributable to metabolic risks from 1990 to 2019
Authors: Qing-Qing Xing, Jing-Mao Li, Chen Chen Zhi-Jian, Xiaoyun Lin, You You Yan-Ying, Mei-Zhu Hong, Shangeng Weng, Jin-Shui Pan
Journal: Journal of Hepatology (2023)
Preclinical characterization of HPG7233, a potent, liver-target and highly selective thyroid hormone receptor beta agonist for non-alcoholic steatohepatitis
Authors: Michael Xu, Shijia Chen, Fang Guo, Que Liu, Yongheng Liu, Cheng Mo, Yihong Peng, Yating Xiong, Peibin Zhai, Pan Zhang, Xinpeng Zhao, Xin Zhou, Xin-Jie Chu
Journal: Journal of Hepatology (2023)
Deep learning quantification reveals fundamental prognostic role for ductular reaction in biliary atresia
Authors: Iiris Nyholm, Nelli Sjöblom, Maria Hukkinen, Marjut Pihlajoki, Jouko Lohi, Aino Mutka, Päivi Heikkilä, Mark Davenport, Markku Heikinheimo, Johanna Arola, Mikko Pakarinen
Journal: Journal of Hepatology (2023)
Long-term prognosis of patients with non-alcoholic fatty liver disease: a retrospective cohort study to understand the impact of surrogate disease end points on long-term outcomes in South Korea
Authors: Sungwon Chung, Min Kyung Park, Xiao Zhang, Tongtog Wang, Thomas Jemielita, Gail Fernandes, Samuel Engel, Heejoon Jang, Yun Bin Lee, Eun Ju Cho, Jeonghoon Lee, Su Jong Yu, Jung-Hwan Yoon, Yoon Jun Kim
Journal: Journal of Hepatology (2023)
HSD17B13 inhibitors are hepatoprotective and anti-inflammatory in a mouse model of autoimmune hepatitis
Authors: Manuel Roqueta-Rivera, Yaohui Nie, Jordan Butts, Mary Chau, Kelsey Garlick, Archie C. Reyes, Jonathan Lloyd, Joshua Klaene, Yat-Sun Or, Bryan Goodwin
Journal: Journal of Hepatology (2023)
The impact of hepatitis C and socio-demographic variables on Health-related quality of life among patients in Pakistan
Authors: Siwaporn Niyomsri, Josephine Walker, Ejaz Alam, Ambreen Arif, Muhammad Asim, Bazil Ather, Mishal Azam, Auj Chaudhry, Asad Chaudhry, Naheed Choudhry, Graham Foster, Saeed Sadiq Hamid, Aliya Hasnain, Polychronis Kemos, Pir Zarak Khan, Aaron G. Lim, Saad Niaz, Noor Saba, Sultan Sallahuddin, Muhammad Nabeel Shafqat, Huma Qureshi, Wasiuddin Shah, Peter Vickerman
Journal: Journal of Hepatology (2023)
Single-cell RNA sequencing in DIAMOND mice reveals differentially regulated pathways specifically associated with the transition from simple steatosis towards NASH
Authors: Rocío Gallego-Durán, Douglas Maya, Ignacio Benedicto, José María Herranz, Lucía López-Bermudo, Elena Vázquez-Ogando, Rocío Montero-Vallejo, Mª José Robles-Frias, Blanca Escudero-López, Antonio Cárdenas-García, Ana Quintas, Elena Blázquez-López, Francisco Javier Cubero, Javier Vaquero, Yulia Nevzorova, Maite G Fernandez-Barrena, Matías A Avila, Jordi Gracia-Sancho, Rafael Bañares, Franz Martin-Bermudo, Manuel Romero Gomez, Javier Ampuero
Journal: Journal of Hepatology (2023)
RBD1016-a novel anti-HBV GalNAc-siRNA drug resulted in sustained HBsAg reduction and seroconversion in mice models
Authors: Li Ming Gan, Shuquan Zheng, Feng Li, Zhaoxu Guo, Hong Yu, Hongyan Zhang, Zicai Liang, Shan Gao
Journal: Journal of Hepatology (2023)
Vebicorvir, entecavir, and pegylated interferon in patients with hepatitis B e antigen positive chronic hepatitis B virus infection: findings from a phase 2, randomized open-label study in China
Authors: Xieer Liang, Jinlin Hou, Yujuan Guan, Zhanqing Zhang, Qing Xie, Jidong Jia, Jifang Sheng, Qin Ning, Wang Yang, Afsaneh Mozaffarian, Nuruddin Unchwaniwala, Jieming Liu, Katie Zomorodi, Luisa M. Stamm, Steven J Knox, Michele Anderson, Kathryn M. Kitrinos, Grace Wang, Yu Chen, Junqi Niu
Journal: Journal of Hepatology (2023)
Comparison of body weight and lipid profiles following tenofovir disoproxil fumarate or entecavir switchingto tenofovir alafenamide in chronic hepatitis B patients
Authors: Pin-Nan Cheng, Chun-Jen Liu, Jyh-Jou Chen, I-Cher Feng, Hsing-Tao Kuo, Pei-Lun Lee, Ming-Lung Yu, Yencheng Chiu, Chiu Hung-Chih, Shih-Chieh Chien, Pei-Jer Chen
Journal: Journal of Hepatology (2023)
Diagnostic and prognostic performance of the SAFE score in non-alcoholic fatty liver disease
Authors: Guanlin Li, Huapeng Lin, Pimsiri Sripongpun, Yan Liang, Xinrong Zhang, Vincent Wai-Sun Wong, Grace Lai-Hung Wong, W. Ray Kim, Terry Cheuk-Fung Yip
Journal: Journal of Hepatology (2023)
Depletion of excess liver copper ameliorates liver damage in a mouse model of chronic cholestatic liver disease
Authors: Dennis Koob, Judith Nagel, Jingguo Li, Sebastian Zimny, Ralf Wimmer, Gerald Denk, Martin Roderfeld, Elke Roeb, Svetlana Lutsenko, Hans Zischka, Simon Hohenester
Journal: Journal of Hepatology (2023)
Transcriptional analysis of HBV infected liver after treatment with selgantolimod reveals longitudinal changes in both inflammation-related pathways and B cell receptor repertoire
Authors: Nikita Kolhatkar, Circe McDonald, Sam Kim, Leonard Sowah, Jeffrey Wallin, Wan-Long Chuang, Yao-Chun (Holden) Hsu
Journal: Journal of Hepatology (2023)
Abstract 4427: Acquiring Direct Flow Based on the Angiosome Concept in Endovascular Therapy Saves More Limbs Than Increasing the Number of Patent Run-off Vessels in Patients With Critical Limb Ischemia
Authors: Osamu Iida, Shinsuke Nanto, Masaaki Uematsu, Takakazu Morozumi, Tetsuya Watanabe, Masashi Fujita, Masaki Awata, Toshinari Onishi, Fusako Sera, Kuniyasu Ikeoka, Shin Okamoto, Nobuaki Tanaka, Haruyo Yasui, Takayuki Ishihara, Tomoharu Dohi, Tsuyoshi Mishima, Seiki Nagata
Journal: Circulation (2009)

Background: Recently, endovascular therapy (EVT) has become an attractive alternative to bypass surgery in patients with critical limbs ischemia (CLI). However, whether acquiring direct flow to the...
Combination therapy of TERN-501, a selective agonist of thyroid hormone receptor (THR) beta with TERN-101, a farnesoid X receptor (FXR) agonist improves non-alcoholic steatohepatitis (NASH) in a GAN diet-induced and biopsy-confirmed mouse model
Authors: Christopher Jones, Malte H. Nielsen, Denise Oró, Michael Feigh, Xiao Teng, Anthony Lie, Gideon Ho, Jeffrey Jasper
Journal: Journal of Hepatology (2023)
A screening strategy of hidden compensated advanced chronic liver disease in diabetic outpatients using sequential and automatic fibrosis-4 and enhanced liver fibrosis scores
Authors: Clara Amiama Roig, Miriam Romero, María Sanz de Pedro, Alexa Pamela Benitez Valderrama, Cristina Suárez Ferrer, Carlota Siljestrom Berenguer, Mariana Serres Gómez, Carmen Amor, Irene Gonzalez Diaz, Noemi González Pérez de Villar, Antonio Buño Soto, Antonio Olveira Martín
Journal: Journal of Hepatology (2023)
Variation in the presentation pattern of primary biliary cholangitis (PBC) in Spain according to the diagnostic period: data from the Spanish registry of cholestatic and autoimmune liver diseases (COLHAI)
Authors: Sergio Rodriguez-Tajes, Álvaro Díaz-González, Mercedes Vergara Gómez, Judith Gómez-Camarero, Javier Ampuero, Beatriz Mateos Muñoz, Diana Horta, Javier Salmerón, Inmaculada Castello, Rosa M. Morillas, Manuel Hernández Guerra, Carmen Álvarez-Navascués, Javier Martinez, Ismael El Hajra Martínez, Raul J. Andrade, Montserrat García-Retortillo, Ana Barreira, Mar Riveiro Barciela, Magdalena Salcedo, Maria Carlota Londoño
Journal: Journal of Hepatology (2023)
Atezolizumab plus bevacizumab for patients with unresectable hepatocellular carcinoma and high hepatitis B viral load: focusing on hepatic safety and viral kinetics
Authors: San-Chi Chen, Hsiao-Hui Sophie Tsou, Teng-Yu Lee, Hung-Wei Wang, Yen-Hao Chen, Tseng-En Wang, Yung-Yeh Su, Shengshun Yang, Chang-Fang Chiu, Tsang-Wu Liu, Ann-Lii Cheng, Li-Tzong Chen, Chiun Hsu
Journal: Journal of Hepatology (2023)
Primary results from MAESTRO-NASH a pivotal phase 3 52-week serial liver biopsy study in 966 patients with NASH and fibrosis
Authors: Stephen Harrison, Pierre Bedossa, Cynthia Guy, Jörn Schattenberg, Rohit Loomba, Rebecca Taub, Dominic Labriola, Sam Moussa, Guy Neff, Arun Sanyal, Mazen Noureddin, Meena Bansal, Naim Alkhouri, Vlad Ratziu
Journal: Journal of Hepatology (2023)
Allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain
Authors: Chunhao Zhu, Xiaobing Lan, Zhiqiang Wei, Jianqiang Yu, Jian Zhang
Journal: Acta Pharmaceutica Sinica B (2023)

Neuropathic pain is a debilitating pathological condition that presents significant therapeutic challenges in clinical practice. Unfortunately, current pharmacological treatments for neuropathic pain lack clinical efficacy and often lead to harmful adverse reactions. As G protein-coupled receptors (GPCRs) are widely distributed throughout the body, including the pain transmission pathway and descending inhibition pathway, the development of novel neuropathic pain treatments based on GPCRs allosteric modulation theory is gaining momentum. Extensive research has shown that allosteric modulators targeting GPCRs on the pain pathway can effectively alleviate symptoms of neuropathic pain while reducing or eliminating adverse effects. This review aims to provide a comprehensive summary of the progress made in GPCRs allosteric modulators in the treatment of neuropathic pain, and discuss the potential benefits and adverse factors of this treatment. We will also concentrate on the development of biased agonists of GPCRs, and based on important examples of biased agonist development in recent years, we will describe universal strategies for designing structure-based biased agonists. It is foreseeable that, with the continuous improvement of GPCRs allosteric modulation and biased agonist theory, effective GPCRs allosteric drugs will eventually be available for the treatment of neuropathic pain with acceptable safety.
Revisiting asthma pharmacotherapy: where do we stand and where do we want to go?
Authors: Mario Cazzola, Clive P. Page, Maria Gabriella Matera, Paola Rogliani, Nicola A. Hanania
Journal: European Respiratory Journal (2023)

Several current guidelines/strategies outline a treatment approach to asthma, which primarily consider the goals of improving lung function and quality of life and reducing symptoms and exacerbations. They suggest a strategy of stepping up or down treatment, depending on the patient's overall current asthma symptom control and future risk of exacerbation. While this stepwise approach is undeniably practical for daily practice, it does not always address the underlying mechanisms of this heterogeneous disease. In the last decade, there have been attempts to improve the treatment of severe asthma, such as the addition of a long-acting antimuscarinic agent to the traditional inhaled corticosteroid/long-acting β2-agonist treatment and the introduction of therapies targeting key cytokines. However, despite such strategies several unmet needs in this population remain, motivating research to identify novel targets and develop improved therapeutic and/or preventative asthma treatments. Pending the availability of such therapies, it is essential to re-evaluate the current conventional "one-size-fits-all" approach to a more precise asthma management. Although challenging, identifying "treatable traits" that contribute to respiratory symptoms in individual patients with asthma may allow a more pragmatic approach to establish more personalised therapeutic goals.