tbuckley/cabot-search huggingface dataset:
Predictors for postoperative cranial nerve complications in carotid body tumor resection: a retrospective cohort study
Authors: Hoda Alimohamad, Dilek Yilmaz, Perla J. Marang-van de Mheen, Jeroen Jansen, Jaap F. Hamming, Abbey Schepers
Journal: International Journal of Surgery (2023)

Introduction: Carotid Body Tumors (CBTs) are slow-growing benign tumors. Therefore, surgical resection is considered in case of tumor growth. Timing of surgery is of the utmost importance as the risk of iatrogenic surgical complications increases when resecting larger tumors, whereas on the other hand resections for asymptomatic small CBT should be prevented. The primary aim of this study was to identify which tumor size or dimension is most accurate to predict nerve injury in patients undergoing resection of a CBT. Material and methods: This retrospective cohort study included patients who underwent surgical resection of CBT at the university hospital in South-Holland. Baseline patient characteristics and tumor measurements were retrieved from the medical records. We assessed how the different methods of measuring the size of the tumor were interrelated using Pearson correlation. Logistic regression was used to assess which variables were independently associated with nerve injury, including age at surgery, Shamblin classification and those dimensions that captured different aspects of tumor size (rather than measuring the same as shown by high correlations) as possible independent variables. Results: In 125 patients, 143 CBT were resected whereof in 35 cases cranial nerve injury occurred, (transient in 16 cases and permanent in 19 cases). The risks for nerve injury increased with larger tumor size and Shamblin classification. Logistic regression analysis showed that the anterior-posterior (AP) diameter significantly increased the odds of a nerve injury, a doubling for every 1 cm increase in AP diameter (odds ratio [95%CI] 2.12[1.29-3.48], P -value=0.003. Conclusion: This study shows that measured tumor size in AP plane is a strong predictor for postoperative nerve injury of a CBT resection. This predictor can be used in daily clinic to give insight in operative risks. More research is needed in order to select the most appropriate time window for CBT resection.
Global trends and prospects in health economics of robotic surgery: a bibliometric analysis
Authors: Yihao Peng, Yuancheng Liu, Sicen Lai, Yixin Li, Zexu Lin, Lingjia Hao, Jingyi Dong, Xu Li, Kai Huang
Journal: International Journal of Surgery (2023)

Background: Over ten million robotic surgeries have been performed. However, the cost and benefit of robotic surgery need to be evaluated to help hospitals, surgeons, patients, and payers make proper choices, making a health economic analysis necessary. We revealed the bibliometric profile in the field of health economics of robotic surgery to prompt research development and guide future studies. Materials and Methods: The Web of Science Core Collection scientific database was searched for documents indexed from 2003 to December 31, 2022. Document types, years, authors, countries, institutions, journal sources, references, and keywords were analyzed and visualized using the Bibliometrix package, WPS Office software, Microsoft PowerPoint 2019, VOSviewer software (version 1.6.18), ggplot2, and Scimago Graphica. Results: The development of the health economics of robotic surgery can be divided into three phases: slow growing (2003-2009), developing (2010-2018), and fast-developing (2019-2022). HU JC and CHANG SL were the most active and influential authors, respectively. The USA produced the most documents, followed by China, and Italy. Korea had the highest number of citations per document. SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES accepted most documents, whereas ANNALS OF SURGERY, EUROPEAN UROLOGY, and JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY had the highest number of citations per document. The JOURNAL OF ROBOTIC SURGERY is promising. The most cited document in this field is New Technology and Health Care Costs - The Case of Robot-Assisted Surgery in 2010. The proportion of documents on urology is decreasing, while documents in the field of arthrology are emerging and flourishing. Conclusion: Research on the health economics of robotic surgery has been unbalanced. Areas awaiting exploration have been identified. Collaboration between scholars and coverage with provisions for evidence development by the government is needed to learn more comprehensively about the health economics of robotic surgery.
Anti–Epidermal Growth Factor Receptor Maintenance Therapy in Metastatic Colorectal Cancer—Another Piece to the Puzzle
Authors: Federica Morano, Filippo Pietrantonio
Journal: JAMA Network Open (2023)

Valérie Boige, MD, PhD; Hélène Blons, MD, PhD; Eric François, MD; Meher Ben Abdelghani, MD; Jean-Marc Phelip, MD, PhD; Valerie Le Brun-Ly, MD; Laurent Mineur, MD; Marie Pierre Galais, MD; Anne-Laure Villing, MD; Vincent Hautefeuille, MD; Laurent Miglianico, MD; Christelle De La Fouchardière, MD; Dominique Genet, MD; Nadia Levasseur, MD; Charles-Briac Levaché, MD; Nicolas Penel, MD; Emmanuel Mitry, MD, PhD; Stéphane Jacquot, MD; Thomas Aparicio, MD, PhD; Emilie Brument, MS; Sophie Gourgou, MS; Florence Castan, MS; Olivier Bouché, MD, PhD
Adding to the confusion in more than just the name
Authors: Jacob George
Journal: Clinical and Molecular Hepatology (2023)

The year 2020 witnessed a paradigm shift in the way we conceptualised and thought about the fatty liver disease which is responsible for a majority of the cases we see in routine clinical practice.For the preceding four decades, non-alcoholic fatty liver disease (NAFLD), a term coined to define a histological lesion, was used to describe a disease entity that clearly was common and rising in prevalence in parallel with that of diabetes and overweight/obesity.Despite decades of discomfort with the term, NAFLD told clinicians and patients what the disease is not and not what the disease is, and was associated with the stigma linked to the term alcohol.Inertia as is common in many areas of medicine persisted.All this changed with two landmark papers by an international panel that proposed a new term, metabolic (dysfunction) associated fatty liver disease or MAFLD, and a new definition (1, 2).What is not as well appreciated by the field is that the papers were a proposal firstly of a term that reflected accumulated knowledge on disease pathogenesis and secondly and perhaps more importantly, it proposed a set of criteria on exactly what constituted the disease.The papers were published to wide acclaim (and some discontent) as a conceptual advance in the field and were there for all clinicians to examine for its clinical utility at the bedside and for clinical research.As fatty liver disease due to metabolic dysregulation impacts the life-course, paediatric criteria were also proposed (3).Subsequent years have seen more than 4000 citations for the two sentinel papers, over 7000 publications using the MAFLD terminology and definition, and widespread acceptance in clinical practice guidelines including the first by the Asian Pacific Association for the Study of Liver (APASL) (4), the middle east and north Africa (5), the Chinese Society of Hepatology (6) and many other national societies as well as patient organisations (7).From the perspective of clinical research, MAFLD and its definition demonstrated clinical utility, increased disease awareness, and importantly, identified
Virus
Authors: Jack Coulehan
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The crosstalk between ferroptosis and anti‐tumor immunity in the tumor microenvironment: molecular mechanisms and therapeutic controversy
Authors: Yichen Zheng, Lingqi Sun, Jiamin Guo, Ji Ma
Journal: Cancer Communications (2023)

The advent of immunotherapy has significantly reshaped the landscape of cancer treatment, greatly enhancing therapeutic outcomes for multiple types of cancer. However, only a small subset of individuals respond to it, underscoring the urgent need for new methods to improve its response rate. Ferroptosis, a recently discovered form of programmed cell death, has emerged as a promising approach for anti-tumor therapy, with targeting ferroptosis to kill tumors seen as a potentially effective strategy. Numerous studies suggest that inducing ferroptosis can synergistically enhance the effects of immunotherapy, paving the way for a promising combined treatment method in the future. Nevertheless, recent research has raised concerns about the potential negative impacts on anti-tumor immunity as a consequence of inducing ferroptosis, leading to conflicting views within the scientific community about the interplay between ferroptosis and anti-tumor immunity, thereby underscoring the necessity of a comprehensive review of the existing literature on this relationship. Previous reviews on ferroptosis have touched on related content, many focusing primarily on the promoting role of ferroptosis on anti-tumor immunity while overlooking recent evidence on the inhibitory effects of ferroptosis on immunity. Others have concentrated solely on discussing related content either from the perspective of cancer cells and ferroptosis or from immune cells and ferroptosis. Given that both cancer cells and immune cells exist in the tumor microenvironment, a one-sided discussion cannot comprehensively summarize this topic. Therefore, from the perspectives of both tumor cells and tumor-infiltrating immune cells, we systematically summarize the current conflicting views on the interplay between ferroptosis and anti-tumor immunity, intending to provide potential explanations and identify the work needed to establish a translational basis for combined ferroptosis-targeted therapy and immunotherapy in treating tumors.
Housing Mobility Intervention for Childhood Asthma—Reply
Authors: Craig Evan Pollack, Elizabeth C. Matsui, Corinne A. Keet
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nationwide analysis of prehospital tranexamic acid for trauma demonstrates systematic bias in adherence to treatment guidelines: a retrospective cohort study
Authors: Ateeq Almuwallad, Elaine Cole, Andrea Rossetto, Karim Brohi, Zane Perkins, Ross Davenport
Journal: International Journal of Surgery (2023)

Background: Prehospital (PH) tranexamic acid (TXA) improves survival from trauma haemorrhage. Injury mechanism, physiology and sex demographics vary with patient age. We hypothesised that these factors influence TXA guideline compliance and examined national trends in PH use to identify any systematic biases in bleeding management. Materials &amp; Methods: UK Trauma Audit &amp; Research Network data for TXA eligible patients admitted to Major Trauma Centres were divided into cohorts: 2013-2015 (n=32,072) and 2017-2019 (n=14,974). Patients were stratified by PH, Emergency Department (ED) or no TXA use. Logistic regression models explored interaction between PH variables and TXA administration. Results are presented as Odds Ratios (OR) with 95% Confidence Intervals (CI). Results: PH TXA use increased from eight percent to 27% over time ( P &lt;0.001). Only three percent of eligible patients who fell &lt;2 m received PH TXA vs. 63% with penetrating injuries ( P &lt;0.001). Older patients eligible for pre-hospital TXA were less likely to receive it compared to younger patients (≥65 y old: 590 [13%] vs &lt;65 y old: 3361 [33%], P &lt;0.001). There was significant interaction between age and sex with fewer older women receiving PH TXA. In shocked patients, one third of females compared to a fifth of men did not receive TXA ( P &lt;0.001). There was a decrease in pre-hospital TXA use as age increased ( P &lt;0.001). Conclusions: Despite a three-fold increase in use, treatment guidance for PH TXA is not universally applied. Older people, women and patients with low energy injury mechanisms appear to be systematically under-treated. Training and education for pre-hospital providers should address these potential treatment biases.
Error in Byline
Journal: JAMA Network Open (2023)

Huiyul Park, MD, PhD; Eileen L. Yoon, MD, PhD; Takanori Ito, MD, PhD; Ae Jeong Jo, PhD; Mimi Kim, MD, PhD; Jonghyun Lee, PhD; Hye-Lin Kim, PhD; Taeang Arai, MD, PhD; Masanori Atsukawa, MD, PhD; Miwa Kawanaka, MD, PhD; Hidenori Toyoda, MD, PhD; Masatoshi Ishigami, MD, PhD; Ming-Lung Yu, MD, PhD; Dae Won Jun, MD, PhD; Mindie H. Nguyen, MD, MAS
Potential Discrepancies in Sensitivity of Fracture Prediction Tools—Reply
Authors: Carolyn J. Crandall, Kristine E. Ensrud
Journal: JAMA Internal Medicine (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Preoperative prognostic predictors and treatment strategies for surgical procedure focused on the Sequential Organ Failure Assessment score in nonocclusive mesenteric ischemia: A multicenter retrospective cohort study
Authors: Takaaki Murata, Nobuo Yamaguchi, Yutaro Shimomoto, Yumi Mikajiri, Yuki Sasaki, Kensuke Konagaya, Yuto Igarashi, Naoki Sawamura, Kota Yamamoto, Nao Kume, Yuma Suno, Shuji Kurata, Tetsuya Kasetani, Ichiro Kato, Tomoki Nishida, Hirohisa Hirata, Katsunori Miyake, Takahisa Oonishi, Naoko Isogai, Ryuta Fukai, Hiroyuki Kanomata, Rai Shimoyama, Hiroyuki Kashiwagi, Tomohiro Takenoue, Takahiro Terashima, Hiroyuki Murayama, Shunsaku Kohriki, Takeshi Morita, Mutsuo Takaki, Hidemitsu Ogino, Takayuki Kanemaru, Ken Sano, Norimitsu Kurogi, Kazunao Watanabe, Masahiro Hirata, Jun Kawachi
Journal: International Journal of Surgery (2023)

Background: Several large-scale studies have assessed endovascular and surgical treatment methods for nonocclusive mesenteric ischemia (NOMI); however, the prognostic factors for NOMI remain unclear. Therefore, this study aimed to evaluate risk factors for in-hospital mortality among patients with NOMI who underwent laparotomy and to examine therapeutic strategies that may improve the prognosis. Materials and Methods: In this multicenter retrospective study, we reviewed the electronic medical records retrieved from the inpatient database of patients with NOMI at eight district general hospitals between January 2011 and January 2021. A total of 88 patients who underwent laparotomies were divided into survivor and non-survivor groups, and statistical analysis was performed to determine clinical physiological factors. Results: Exploratory laparotomy based on second-look surgery was the first treatment choice. The overall mortality rate was 48.8%, with a male-to-female ratio of 1.1:1. The median Sequential Organ Failure Assessment (SOFA) score was 8 [interquartile range: 3.75–14.2], and the median SOFA scores were 5 [3–7] in the survivor group and 13 [9–17.5] in the non-survivor group. Univariate analysis revealed a significant difference in body mass index ( P &lt;0.001), hypoglycemia ( P =0.0012), previous cardiovascular surgery ( P =0.0019), catecholamine use ( P &lt;0.001), SOFA score ( P &lt;0.001), platelet count ( P =0.0023), and lactate level ( P &lt;0.001). Logistic regression analysis using the factors with significant differences revealed that SOFA score ≥10 (odds ratio 23.3; 95% confidence interval 1.94–280.00; P =0.013) was an independent prognostic factor. In addition, catecholamine use was suggested as a factor with a SOFA score ≥10. Conclusion: This study confirmed that a SOFA score of ≥10 may be associated with increased mortality. While closely monitoring low blood pressure and renal dysfunction, survival rates may be improved if surgical intervention is performed before the SOFA score reaches ≥10.
Comparation of drug-eluting stents and control therapy for the treatment of infrapopliteal artery disease: a Bayesian analysis
Authors: Yang Li, XuWei Shen, Hui Zhuang
Journal: International Journal of Surgery (2023)

Background: Critical limb-threatening ischemia is a life-threatening disease which often combines with infrapopliteal arterial disease. Percutaneous transluminal angioplasty (PTA) is recommended as the first line treatment for infrapopliteal arterial disease. Drug eluting stent (DES) is another widely used option; however, its long-term therapeutic effect is controversial. The effectiveness of different DES for infrapopliteal arterial disease needs further exploration. Methods and results: The PubMed, EMBASE, Cochrane Library and Clinical trials were systematically searched from inception to 1 Feb 2023. Literatures were included if the study was original, peer-reviewed, published in English or Chinese, and contained patients diagnosed with simple infrapopliteal arterial disease or with properly treated combined inflow tract lesions before or during the study procedure. A total of 953 patients, 504 in the DES group and 449 in the PTA/BMS group, from twelve randomised controlled trials were included in the meta-analysis. The results showed that DES is superior to control group for improving clinical patency, reducing the restenosis rate, and reducing the amputation rate at 6 months, 1 year, and 3 years post-treatment (at 3 years, risk ratio [RR]: 1.90, 95% confidence interval [CI] 1.23–2.93; RR: 0.87, 95% CI 0.79–0.96; RR: 0.60, 95% CI 0.36–1.00, P =0.049). In addition, subgroup analyses suggested that DES is superior to BMS and PTA in improving clinical patency and reducing target lesion revascularisation and restenosis rates at 6 months and 1-year post-treatment. The network meta-analysis indicated that sirolimus-eluting stent (SES) was superior for improving clinical patency (at 1 year, RR: 0.23, 95% CI 0.08–0.60) and reducing the restenosis rate (at 6 months, RR: 31.58, 95% CI 4.41–307.53, at 1 year, RR: 3.80, 95% CI 1.84–8.87) significantly. However, according to the cumulative rank probabilities test, everolimus-eluting stent (EES) may have the lowest target lesion revascularisation rates and amputation rates at 1-year post-treatment (the cumulative rank probability was 77% and 49%, respectively). Conclusions: This systematic review and network meta-analysis showed that DES was associated with more clinical efficacy than PTA/BMS significantly. In addition, SES and EES may have better clinical benefits.
Re: ChatGPT encounters multiple opportunities and challenges in neurosurgery
Authors: Qin-xin Yu, Rui-cheng Wu, De-chao Feng, Deng-xiong Li
Journal: International Journal of Surgery (2023)

aNingbo Clinical Pathology Diagnosis center, Ningbo City, Zhejiang Province, China bDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, China Qin-xin Yu, Rui-cheng Wu, De-chao Feng, Both authors contributed equally to this work and are listed as co-first authors. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Ningbo Clinical Pathology Diagnosis center, Ningbo City, Zhejiang Province, China, Tel: +86-18313736646. E-mail address: [email protected] (Q-x. Yu, ). *Corresponding author. Address: Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu City, Sichuan Province, China, Tel: +86-28-85422444, Fax: +86-28-85422451. E-mail address: [email protected] (D-x. Li). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
Automated Large Vessel Occlusion Detection Software and Thrombectomy Treatment Times
Authors: Juan Carlos Martinez-Gutierrez, Youngran Kim, Sergio Salazar-Marioni, Muhammad Bilal Tariq, Rania Abdelkhaleq, Arash Niktabe, Anjan N. Ballekere, Ananya S. Iyyangar, Mai Le, Hussain Azeem, Charles C. Miller, Jon E. Tyson, Sandi Shaw, Peri Smith, Mallory Cowan, Isabel Gonzales, Louise D. McCullough, Andrew D. Barreto, Luca Giancardo, Sunil A. Sheth
Journal: JAMA Neurology (2023)

The benefit of endovascular stroke therapy (EVT) in large vessel occlusion (LVO) ischemic stroke is highly time dependent. Process improvements to accelerate in-hospital workflows are critical.