tbuckley/cabot-search huggingface dataset:
Dietary Fiber
Authors: Robert E. Rakel
Journal: JAMA (1990)

<h3>To the Editor.—</h3> The Council Report on dietary fiber and health<sup>1</sup>provided a comprehensive overview of the importance of consuming adequate amounts of fiber. As discussed in the section on heart disease, aggressive nutrition management with fiber is recommended increasingly by many investigators for treating hypercholesterolemia. However, my experience has shown that it is often difficult for patients to consume enough soluble fiber, through diet alone, to obtain the desired results. Supplements are often required. Although I agree with the report that dietary fiber supplements should not be regarded as a replacement for high-fiber foods, a soluble fiber supplement like psyllium provides a concentrated, low-calorie, cost-effective source of soluble fiber that can be a beneficial part of a heart-healthy nutrition program with no significant side effects. I have found that the addition of a psyllium supplement to a prudent diet is a rational and effective alternative to systemic drugs.
Osteoporotic Bone Fragility
Authors: Robert P. Heaney
Journal: JAMA (1989)

We evaluated ultrasound transmission velocity at the patella as an indicator of osteoporotic fragility in 293 nonobese women. Osteoporosis was defined by atraumatic vertebral compression deformity. Ultrasound velocity averaged 1954 ±71 (±SD) m/s in premenopausal normal women and declined significantly with age after menopause, largely independently of age-related loss of spine bone mass. Postmenopausal osteoporotic women had lower velocities than normal women (-76 m/s). After allowing for slight differences in age between the groups, the difference ( - 54 m/s) was still significant. Women with velocities below 1825 m/s were about six times more likely to have one or more fractures than women with velocities above that level. By sensitivity-specificity analysis, ultrasound velocity discriminated between normal and osteoporotic women as well as direct measurement of spine bone mass. Ultrasound velocity measures both bone mass and a component of bone fragility distinct from decreased mass; it is a potentially valuable new tool for evaluating women for osteoporotic fragility. (<i>JAMA</i>. 1989;261:2986-2990)
Phase II trial of extended dose anti-CTLA-4 antibody ipilimumab (formerly MDX-010) with a multipeptide vaccine for resected stages IIIC and IV melanoma
Authors: J. S. Weber, A. Sarnaik, S. Targan, B. Yu, D. Morelli, P. Urbas, N. Maker, M. Yellin, G. Nichol
Journal: Journal of Clinical Oncology (2009)

9023 Background: Ipilimumab is a human anti-CTLA-4 antibody shown to have clinical activity in melanoma that is associated with immune-related adverse events (IrAEs). Methods: 50 HLA A*0201 positive patients with resected stages IIIC/IV melanoma received MART-1/gp100/tyrosinase peptides with adjuvant Montanide ISA 51 12 times subcutaneously with Ipilimumab at 3 or 10 mg/kg intravenously every 8 weeks for 12 months, and 25 HLA A *0201 negative patients received Ipilimumab alone at 10 mg/kg. Primary endpoints were toxicity and the achievement of a 40% rate of tolerable IrAEs. Immune responses measured by ELISPOT and tetramer assays, and time to relapse were also assessed. 3 melanoma peptides were administered at 1000 mcg/dose each. Results: Median age was 58, with 44 men and 31 women. 46 patients had stage IV, and 29 had stage IIIC resected disease. 19/75 (25%) patients had grades 3–4 IrAEs that were dose-limiting. No patient with dose limiting toxicity required hospitalization and all returned to baseline status with the use of systemic steroids. Assays of induction of IL-17 secreting T cells showed a positive association with freedom from relapse (p=0.049). Change in slope of the increase in total lymphocyte count at four weeks was also associated with a trend toward freedom from relapse and development of an IrAE. 27 of 75 patients have relapsed with a median of 23 months of follow-up. 10 were again rendered NED surgically and are alive without disease. 68 patients are alive, 10 with disease. Only 1/19 patients with grade 3/4 IrAE has died of disease, compared to 6/56 without a dose limiting IBE. 23 of 27 relapses occurred without a grade 3/4 IrAE, compared with 15 IrAEs in 48 patients without a relapse. ELISPOT assays showed that patients at 10 mg/kg actually had decreased responsiveness in fresh PBMC to PHA and the CEF (CMV, EBV, FLU) pool of peptides. Conclusions: IrAEs are associated with clinical benefit in patients with resected high-risk melanoma receiving Ipilimumab with or without a peptide vaccine. Increases in IL-17 secreting CD4 T cells and the slope of increase in total lymphocytes over 4 weeks are associated with freedom from relapse. These data support testing the current regimen at 10 mg/kg in a larger randomized trial. [Table: see text]
Morphological changes in brains of boxers
Authors: P. W. Lampert
Journal: JAMA (1984)

THE COUNCIL of the American Medical Association recently issued a report on brain damage in boxers.<sup>1</sup>Better medical supervision and stricter regulations to control this dangerous sport were recommended. Similar calls for actions are usually heard whenever the news media get excited about a fatal knockout in the ring. We agree with the Council's recommendations but question the logic of proposing regulations aimed at preventing injury when the purpose of boxing is to inflict injury. The public enjoys paying for the spectacle, and for this reason boxers will continue battering each other with damaging force. Professional boxers are capable of delivering blows with forces that may exceed 100 gravity.<sup>2</sup>Such blows applied to the movable head cause the soft brain to glide and swirl within the skull, tearing vessels and nerve fibers. A variety of factors—notably the direction, intensity, velocity, and number of blows—determine the location, type, and
WHAT FASTING MEANS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Modulating the thrombogenic balance in a murine model of vascular remodelling: a role for TFPI Ripudamanjit Singh, Shuchong Pan, Timothy Peterson, Cheryl Mueske, Tyra Witt, Laurel Kleppe, Jean-Yea Chang, Noel Caplice, Robert Simari. Mayo Clinic, Rochester, MN
Journal: Journal of the American College of Cardiology (2001)
AUTHORS' REPLY
Authors: J. C Hogg
Journal: Thorax (1994)

REPLY DrThurlbeck objects to our conclusion that the severity of the lesions of the bronchioles and parenchyma assessed by grading techniques in resected lung specimens do not correlate with lung function measurements obtained in the same subjects.We agree that this conclusion is at variance with much that is in the literature and, indeed, re- ported it for that reason.The data we pre- sented make two basic points: (1) that rather extensive emphysematous destruction of the lung can be present in patients who have a normal FEVI, and (2) that a reduction in FEV, did not correlate with increased inflammatory changes in the peripheral airways assessed with current grading systems.This does not mean that we think emphysematous destruction is not important, only that its presence does not explain the decline in FEVI.Similarly, we did not mean to imply that the abnormal peripheral airway function may not eventually be explained by the effects of the inflammatory process in these airways -only that current morphological grading systems do not identify the lesions responsible for the abnormalities in function.We agree with his closing statement that airflow obstruction is a complicated mat- ter in which the different lesions ofthe bronchi (not just chronic bronchitis), bronchioles (not just the Cosio score), and parenchyma (not just emphysema) contribute to the decline in function.Specific responses to the otherpoints raised in his letter follow.The criticism concerning our failure to re- port data on tumour size and stage does not recognise that we have previously reported these data on the first 143 cases entered into our study.'Tumour size, involvement of
Long-Term Outcome of B-CLL Patients Treated in a Prospective Trial Evaluating Combination of Oral Fludarabine and Cyclophosphamide As Frontline Therapy
Authors: Romain Guièze, Olivier Tournilhac, Karim Maloum, Stéphane Leprêtre, Corinne Haioun, Pierre Feugier, Alain Delmer, Michel Leporrier, Bruno Cazin
Journal: Blood (2011)
Handbuch DER NORMALEN UND pathologischen Physiologie. Mit Berücksichtigung der experimentellen Pharmakologie.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Severe tracheobronchial stenosis in a patient with Crohn's disease
Authors: T. Kuz´niar, C. Sleiman, O. Brugie`re, O. Groussard, H. Mal, F. Mellot, R. Pariente, J. Malolepszy, M. Fournier
Journal: European Respiratory Journal (2000)

Tracheobronchial involvement in Crohn9s disease is rare, usually associated with symptoms of tracheobronchitis, and typically responds well to steroids. The authors report a case of a 29-yr old patient with Crohn9s disease, who presented with dyspnoea, fever, and a productive cough. Computed tomography of the chest revealed extensive nodular tracheobronchial stenosis, that was accompanied by severe mucosal inflammation at bronchoscopy. High-dose oral steroids diminished the mucosal inflammation, but had limited efficacy on the underlying tracheobronchial stenosis. It is speculated that this relative ineffectiveness of steroids may be due to the persistence of the untreated inflammatory process.
Use of Coronary Calcification Scores to Predict Coronary Heart Disease—Reply
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The association between atopic dermatitis and hand eczema: a systematic review and meta-analysis
Authors: S.M.D. Ruff, K.A. Engebretsen, C. Zachariae, J.D. Johansen, J.I. Silverberg, A. Egeberg, J.P. Thyssen
Journal: British Journal of Dermatology (2018)

Summary Atopic dermatitis (AD), a common type of eczema, is a skin disease of early childhood. It causes intense itching and dry skin. Most children and adults experience eczema of the flexures (bends of the knees and elbows), but some adult patients also have eczema on the face, hands and feet. Traditional atopic hand eczema (HE) is located on the dorsal aspects (backs) of the hands, probably because the skin is thinner here than on the palms. However, AD also increases the risk of HE that develops due to irritants such as soap and water, so-called ‘irritant contact dermatitis’. This subtype of HE often begins on the skin between or on the sides of the fingers but can be located anywhere on the hands including the palms. Importantly, HE can prevent people being able to work and can reduce their enjoyment and quality of life. The present study looked into the link between AD and HE by reviewing published literature and scientific studies. In each study we searched for data on the association between AD and HE. We combined the results from 26 studies, which showed that patients with present or past AD had a 3 to 4-fold increased risk of HE when looking at one-year- and lifetime prevalence of HE (meaning people who developed HE at any point over the course of a given year, or ever in their lives so far, even if they did not have it currently). A slightly weaker association was found when studying the link with current HE. Similar positive associations were found when looking at HE due to exposure to irritants from different occupations, and HE reported in the general population. In conclusion, our analysis showed that patients with AD had a strongly increased likelihood of HE. Clinicians should continue to guide patients with AD away from occupations with high risk of HE where possible. Furthermore, future studies should focus on the importance of determining the association between AD and different types of HE.
Application of a Membrane Model to the Sorptive Interactions of Humic Substances
Authors: Robert L. Wershaw
Journal: Environmental Health Perspectives (1989)

Humic substances, the dark-colored, natural organic polyelectrolytes that are found in practically all soils, sediments, and natural water, strongly interact with both inorganic and organic pollutants. Inorganic cationic species generally undergo complexation reactions with humic substances. The binding of cations, such as cupric ions, by humic substances often markedly reduces their toxicity to aquatic organisms. Some inorganic anionic species, in the presence of metal ions, are sorbed by humic substances. In these instances the metal ions appear to form bridges between the humic substances and the anions. Several different types of interactions take place between organic compounds and humic materials. Hydrophobic organic species partition into either insoluble or soluble humic substances. The insoluble humic substances will remove hydrophobic organic compounds from the aqueous phase, thereby rendering them less mobile. However, soluble humic substances will solubilize hydrophobic organics, increasing their mobility. Other types of interactions between humic substances and organic compounds, such as adsorption and ion exchange, also have been observed. These various interactions between humic substances and pollutants are important in governing their fate and movement in natural water systems, and, for this reason, a detailed understanding of the mechanisms of the interaction is important. A recently developed membrane model of the structure of humic substances is described; this model enables one to better understand the physical-chemical properties of these materials.
Validation of the Lewis score for the evaluation of small-bowel Crohn’s disease activity
Authors: José Cotter, Francisca Dias de Castro, Joana Magalhães, Maria Moreira, Bruno Rosa
Journal: Endoscopy (2015)

Correction to: Validation of the Lewis score for the evaluation of small-bowel Crohn's disease activityEndoscopy 2015; 47(04): 330-335DOI: 10.1055/s-0034-1390894
Opportunistic Non-Hodgkin's Lymphomas Among Severely Immunocompromised HIV-lnfected Patients Surviving for Prolonged Periods on Antiretroviral Therapy—United States
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Commentaire du travail de Ono S et al., pp. 632
Journal: Endoscopy (2015)

See also: Thienopyridine derivatives as risk factors for bleeding following high risk endoscopic treatments: Safe Treatment on Antiplatelets (STRAP) studyEndoscopy 2015; 47(07): 632-637DOI: 10.1055/s-0034-1391354
PNEUMONIA AND SOFT COAL.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ventricular arrhythmias may not be primary cause of sudden death
Authors: W. A. Check
Journal: JAMA (1981)

At a recent conference sponsored by the New York Academy of Sciences, physicians and scientists from several disciplines explored the topic of sudden coronary death, discussing its epidemiology, pathogenesis, and prevention. The purpose of the conference was not to present conclusions but "to start to define sudden death and identify predictors of it," according to co-chairman Edward M. Dwyer, Jr, MD, of Columbia University's College of Physicians and Surgeons, New York. Approximately 400,000 persons die suddenly of heart disease in the United States each year. Furthermore, it is estimated that about 50% die within one hour of symptom onset and that half of those over age 50 years never even reach the hospital. The concept of "sudden" cardiac death as a special category of death from heart disease arose largely in the early 1960s, recalled John Kastor, MD, director of the division of cardiovascular medicine at the University of Pennsylvania
GI oncology/basic
Authors: E Schlichting, T Asplin, T Grotmol, T Lyberg, H Kahler2, A Chiaravalli, M Cornaggia, M Salvadore, N Sonzini
Journal: Gut (1994)

3rd UEGWOslo 1994 vein (9.0%).All 12 patients were operated after they had achieved good gen- eral health and nutritious status.All operations were successful, and TPN provides high degree of the nutritious status of the pts, contributes to the success of the op.itself and decreases the postop.morbidity and mortality.