ESSENTIAL CRYOGLOBULINEMIA
Authors: M J STEINHARDT, G S FISHER
Journal: Annals of Internal Medicine (1955)

Case Reports1 October 1955ESSENTIAL CRYOGLOBULINEMIAMILTON J. STEINHARDT, M.D., GEORGE S. FISHER, M.D., F.A.C.P.MILTON J. STEINHARDT, M.D.Search for more papers by this author, GEORGE S. FISHER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-4-848 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past two decades numerous reports have appeared in the medical literature describing a serum protein which precipitates on exposure to cold.1, 2, 9, 14, 22, 23, 34, 35, 38, 42, 46 This protein has been called cryoglobulin, and occurs in association with or secondary to a variety of disease processes. It is our purpose to report an unusual case of cryoglobulinemia, under our observation for three years, in which no such underlying disease was found present (table 1).CASE REPORTA 45 year old white housewife was first seen in September, 1951, complaining of cold urticaria. Her symptoms...Bibliography1. AdamsAllingLawrence WSELJS: Multiple myeloma—its clinical and laboratory diagnosis with emphasis on electrophoretic abnormalities, Am. J. Med. 6: 141, 1949. CrossrefMedlineGoogle Scholar2. BarrReaderWheeler DPGGCH: Cryoglobulinemia, Ann. Int. Med. 32: 6, 1950. LinkGoogle Scholar3. BayrdHeck EDFJ: Multiple myeloma—a review of 83 proven cases, J. A. M. A. 133: 147 (Jan. 18) 1947. CrossrefMedlineGoogle Scholar4. Blades AN: Cryoglobulinemia in multiple myelomatosis, Brit. M. J. 1: 169 (Jan. 27) 1951. CrossrefMedlineGoogle Scholar5. Bing J: Further investigations on hyperglobulinemia, Acta. med. Scandinav. 103: 547, 565, 1940. CrossrefGoogle Scholar6. 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Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan*Received for publication September 13, 1954.From the Departments of Medicine and Allergy, Grace Hospital and Sinai Hospital, Detroit, Michigan. 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