tbuckley/cabot-search huggingface dataset:
SURGERY OF THE LUNG.
Authors: J. B. MURPHY
Journal: JAMA (1898)

<h3>SURGERY.</h3> We will first consider accidents to and operations on the lungs. Then we will consider the diseases of the lungs and the applications of surgical procedures to them. We will also consider the general pathologic and surgical principles underlying operative procedures on the lung. I propose the following proposition without argument: The important diseases of the lungs are all due to foreign bodies, either mechanical or bacterial Therefore viewing the question from this etiologic standpoint, in the present state of medical science operative procedures should be habitually performed. The general principles are: 1. To place the tissue in such condition as to increase resistance to infection. 2. To remove:<i>a</i>, foreign bodies;<i>b</i>, the products of infection, which in turn are foci for further infection;<i>c</i>, tissue injured beyond repair, which constitutes foyers of new infection. Lung operations divide themselves into two classes: 1. Those that do not perforate
Using the Nicotine Patch to Stop Smoking
Authors: Susan H. Swartz
Journal: JAMA (1995)

<h3>To the Editor.</h3> —In their meta-analysis of transdermal nicotine patch clinical trials, Dr Fiore and colleagues<sup>1</sup>reviewed the efficacy of this therapy compared with placebo patches, with a major emphasis on the relationship of counseling with patch use. Studies were categorized by intensity levels of counseling, and quit rates between "low counseling" and "high counseling" studies were compared. The authors report, "[t]here was no indication that low-intensity or high-intensity counseling resulted in greater efficacy of the nicotine patch in relation to placebo patch," and subsequently advocate a minimal counseling approach with initial transdermal nicotine patch use. There are several problems inherent in using this meta-analysis to arrive at such a conclusion, including two potential sources of bias. First, performing a subgroup analysis for counseling intensity requires comparisons between studies, not across studies. Subjects in this meta-analysis were not randomly exposed to counseling of varying intensity. Given the likelihood that
Biological Interaction of Selenium with Other Trace Elements in Chicks
Authors: G. O. Howell, C. H. Hill
Journal: Environmental Health Perspectives (1978)

Studies were conducted to determine whether or not elements whose valence shell of electrons was similar to that of selenium would reverse the toxicity of selenium to chicks. The elements studied were arsenic, tellurium, tin, and lead. Each of these elements, when added to the diet of chicks, reversed the toxicity of 25 ppm selenium as measured by weight gain. In spite of the protection afforded by these elements, there was no decrease in liver concentration of selenium except with levels of arsenic higher than that needed for reversal of toxicity.
Ageing causes lipid metabolism imbalance and exacerbates steatohepatitis in high-fat diet-fed mice
Authors: Kazuyoshi Kon, Kei Ishizuka, Hyeon-Cheol Lee, Kumiko Arai, Akira Uchiyama, Hiroo Fukada, Shunhei Yamashina, Takehiko Yokomizo, Kenichi Ikejima
Journal: Journal of Hepatology (2020)
Is dietary erucic acid hepatotoxic in pregnancy? An experimental study in rats and hamsters*1, *2
Authors: H REYES
Journal: Hepatology (1995)

The hypothesis that dietary erucic acid may contribute to the pathogenesis of intrahepatic cholestasis of pregnancy has been examined in pregnant rats and hamsters after prolonged feeding of diets containing 25% rapeseed oil rich in erucic acid (40% of fatty acids) or corn oil, without erucic acid. Both dietary oils were well tolerated, although weight gain was 17% to 20% less in animals receiving rapeseed oil. Rats and hamsters were studied on the last day of pregnancy and compared with age- and diet-matched nonpregnant animals. Histological examination showed no major morphologic abnormalities in liver, heart, kidneys, and adrenals. Similar microscopic deposits of fat were found in the livers and hearts of pregnant hamsters of both dietary groups. Chromatographic analysis of fatty acids in liver, heart, and kidney homogenates of hamsters and in isolated rat liver cells reflected the fatty acid composition of the dietary oils: oleic (18:1) and linoleic (18:2) acids were among the predominant fatty acids. Erucic acid was found in a higher proportion in the heart (14% by weight of total fatty acids) than in the liver (3%) and kidneys (3%) of animals fed rapeseed oil. Bile flow and biliary lipid composition was similar in rats and hamsters fed rapeseed or corn oil. Bile flow tended to be less in pregnant than in nonpregnant animals. Pregnant hamsters fed rapeseed oil tended to have the lowest bile flow. The lithogenic index of bile was slightly decreased in pregnant rats and increased in pregnant hamsters, although these proportional changes were similar for both diets. In all circumstances the lithogenic index remained below a value of 1. Biliary excretion of sulfobromophthalein (BSP) and maximal transport capacity of BSP into bile (BSP Tm) were similar in rats fed rapeseed or corn oil diets. In conclusion, no morphologic or hepatic functional abnormalities attributable to the diet could be detected in animals fed rapeseed oil with a high content of erucic acid, whereas pregnancy induced changes in bile secretion in rats and hamsters, irrespective of the diet administered. These observations are still insufficient to reject the possibility that rapeseed oil rich in erucic acid could be involved in the pathogenesis of intrahepatic cholestasis of pregnancy because dietary erucic acid could interact with a genetic metabolic predisposition to induce a disease that seems to be specific to humans.
Dysarthria with tricyclic antidepressants.
Journal: BMJ (1977)

This is often improved if the patient can be persuaded to exercise the sphincters and pelvic muscles persistently and repeatedly.I have no claim to specialised knowledge in this field.But I have been consulted informally by embarrassed women and in many countries-and often with apparently good results-so that I feel the reference to the possibility of exercise should not be neglected.
Emergency treatment of acute drug ingestions
Authors: R. S. Hoffman
Journal: JAMA (1991)

<h3>In Reply.</h3> —I appreciate Dr Hoffman's comments concerning the Emergency Medicine section in the Contempo 1991 issue of<i>JAMA</i>. I agree with Hoffman that the quote in the margin of the article would seem to suggest at first glance that an error in interpretation of the study by Merigian et al<sup>1</sup>was made. However, I would like to point out that the quote in the margin as well as the quote in Hoffman's letter were both taken out of the context of what was stated in the article. My interpretation of the study by Merigian et al was that while these results suggest that gastric emptying and activated charcoal may be unnecessary in asymptomatic patients, "absolute changes in protocols should await corroborative studies." I would also point out that in the<i>American Academy of Clinical Toxicology Update</i>, published quarterly by the American Academy of Clinical Toxicology, the interpretation of
Cost-effectiveness of Homocysteine-Lowering Therapy to Prevent Coronary Heart Disease
Authors: Gere Sunder-Plassmann, Manuela Födinger
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Ethics Teaching
Authors: Robert M. Veatch
Journal: JAMA (1976)

Medical ethics teaching was surveyed at American medical schools. Of 107 schools that responded, 97 indicated some kind of medical ethics teaching. This included, however, 19 schools where teaching was only by discussion of ethical issues in courses not primarily identified as ethics courses. Fifty-six institutions (up from 17 in 1972) reported that they conducted special conferences, lectures, or seminars on issues in medical ethics. Specific medical ethics electives were offered in 47 schools; some kind of required course existed at six institutions. The number of faculties with major commitments to medical ethics teaching increased approximately 50% (from 19 to 31). Several schools now have departments or interdepartmental teaching programs with formal structure and permanent staff. (<i>JAMA</i>235:1030-1033, 1976)
Ultrasound evaluation of the renal transplant
Authors: A. B. Kurtz
Journal: JAMA (1980)

ULTRASOUND in renal transplantation studies may be used for (1) initial pretransplant evaluation in both the donor and the recipient, (2) immediate postsurgical examination, and (3) long-term serial follow-up. The ability of ultrasound to analyze soft tissue, both within and surrounding the kidney, makes it an important complementary examination to the functional information provided by an excretory urogram. An understanding of the ultrasound characteristics of the kidney are important, since changes in these echo patterns are suggestive of disease. The kidney has strong echoes that arise from the outer surface—the capsule. Strong echoes are also produced from the midportion of the kidney and are caused by numerous reflecting interfaces from the renal hilus, defined as the central collecting system, which includes the blood vessels, the fatty fibrous tissue, and the pelvicalyceal system. While any of these structures may become prominent, a separation of the central collecting system usually implies hydronephrosis.
Incorrect Description of Patient Compensation in Methods Section
Authors: Derek Ho, Ekaterina Kraeva, Joshua Schulman, Jared Jagdeo
Journal: JAMA Dermatology (2017)

One advantage of microneedle fractional RF is that it does not depend on specific chromophore absorption and is not affected by tissue diffraction, unlike laser or light-based devices, and is theoretically safe for patients of all skin types.Compared with fractionated CO 2 lasers, microneedle fractional RF may achieve faster healing time, minimal patient downtime, and lower risk of scarring, showing improvement equivalent to or better than that of fractionated CO 2 laser.A limitation with this treatment modality is that physicians are blinded to the depth of penetration of RF energy.In addition, skin impedance strongly affects RF current flow, which may vary with patient age, skin color, and treatment location.In this case, microneedle fractional RF improved the aesthetic and functional aspects associated with chronic radiation dermatitis.We hypothesize that microneedle fractional RF achieved these results through collagen and extracellular matrix remodeling, and we propose that this technique may have a role in treating patients with chronic radiation dermatitis.Microneedle fractional RF therapy represents an advance worthy of investigation by clinical researchers to determine whether the benefits presented herein can be reproduced and benefit additional patients with chronic radiation dermatitis.
Abstract 1403: Combining oligonucleotide library-based RNA fluorescence <i>in situ</i> hybridization and fluorescent immunohistochemistry on the same tissue section
Authors: Robert A. Ach, May Tom-Moy, Peter Tsang, Kelly Kroeger
Journal: Cancer Research (2019)

Abstract The ability to visualize both RNA and protein expression in a single formalin-fixed paraffin-embedded (FFPE) tissue section is a powerful technique for studying biological problems such as the regulation of protein expression and RNA/protein interactions, as well as for antibody characterization and validation. We have leveraged our ability to chemically synthesize oligonucleotides in massively parallel reactions to produce DNA libraries that can be used to generate probes for the detection of DNA or RNA by Fluorescence in situ Hybridization (FISH). The sequences of the oligonucleotides in these libraries are selected in silico using empirically determined criteria so as to avoid repetitive elements or regions homologous to other non-targeted nucleic acids. We have used these oligonucleotide library-derived FISH probes in combination with a novel signal amplification technique to detect the localization of a variety of both coding and non-coding RNAs in fixed tissue culture cells and FFPE tissue sections, using both conventional fluorescence and structured illumination microscopy. We report here combining our RNA FISH methodology with antibody-based fluorescent immunohistochemistry (IHC) detection of proteins on the same FFPE slide. We show that our combined RNA FISH/IHC protocol works on a variety of RNA probe/antibody combinations for both nuclear and cytoplasmic proteins. We also show that our fluorescent assay can be converted to a colorimetric one for both the RNA and protein detection. Citation Format: Robert A. Ach, May Tom-Moy, Peter Tsang, Kelly Kroeger. Combining oligonucleotide library-based RNA fluorescence in situ hybridization and fluorescent immunohistochemistry on the same tissue section [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1403.
Merchandise
Authors: Andrew D. Firlik
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Archiv und Atlas der normalen und pathologischen Anatomie in typischen Röntgenbildern: Die Krankheiten der Nasennebenhöhlen und des Ohres im Röntgenbild
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute granulocytic leukemia in elderly patients
Authors: C. D. Bloomfield
Journal: JAMA (1973)

We reviewed 134 cases of acute granulocytic leukemia in adult patients in three age groups. There were no differences among groups in the nature of onset, initial physical findings, morphologic characteristics, hematologic indices, complications, causes of death, or survival. While patients under 40 years responded more frequently to vigorous chemotherapy, responders over 60 years had equally long remissions and survivals. Patients aged 41 to 60 and 61 to 86 responded equally well. Prospective studies of vigorous chemotherapy in elderly patients with acute leukemia are warranted.
Repeated haemodialysis with a straight silicone rubber cannula.
Authors: J Hawkms, B Xi, Cole Dillard
Journal: BMJ (1967)

2N Z.Ocmber1.67d ruects perbaps a lied capillary ab lit or Emc~slve local capillary development as a result. of reduced arterial saturaton.It differs from the clubbing that develops in chest disease due to excessive reduced ap t The clubbing that I cannot understand at all is the clubbing in bacterial endocarditis, left atrial myzoma, and coeliac disease.Professor Boom: Thank you very much.We must con- clude this was a patient with adult coeliac disease who developed Crohm's disease, whatever that may be.fWe are grateful to,Proiessor J. P. Sblno d and Dr.. D.
Clinical Contraception
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Oxamniquine for treating Schistosoma mansoni infection in Sudan
Journal: BMJ (1978)

transferred to clean test-tubes and 500 ,ul of colour reagent was added.The assay was then completed as described.9Calculation-The glucose standard used in the whole blood method was utilised for calculating the blood spot results.A correction factor (x 1 515) was applied to allow for the difference in final dilution between the two methods.With this technique blood glucose concentrations up to 27 mmol/l (486 mg/100 ml) may be measured, but concentrations up to 54 mmol/l (973 mg/100 ml) may be measured by diluting 125 p1 of the remaining eluate one in one with precipitant. ResultsReproducibility-Reproducibility of the capillary blood spot assays was assessed within and between batches using spots prepared from two volunteers.For the within-batch assessment 10 spots from each volunteer were measured in the same batch, and for the betweenbatch assessment 10 spots from each volunteer were assayed singly in 10 individual assays over two days.A two-day period was used to avoid sample deterioration (see below).Table I gives the results.TABLE i-Within-batch and between-batch reproducibility of capillary blood spot glucose assays (mmol/l).(In each case n= 10) Within-batch Between-batch Coefficient of Coefficient of Mean ± SD variation (0°) Mean ± SD variation (%)
AIDS expert challenges ethical stance on drug trials
Authors: B. Christie
Journal: BMJ (2001)

The right of terminally ill patients for assistance to end their life moved a step closer last week when a woman with motor neurone disease won the battle to have her case reviewed in the high court.Diane Pretty was diagnosed as having the disease in 1999.Now aged 42, she is paralysed from the neck down but is fully mentally competent.She wants to die at home when she chooses but is physically unable to take her own life.On 31 August she won the right to a full judicial review of the director of public prosecution's refusal to guarantee that Mr Pretty would not be prosecuted under the 1961 Suicide Act if he helped to end his wife's life.Her case could be heard within the next month.Under section 2.1 of the act, Mr Pretty could be imprisoned for up to 14 years if he helped his wife to die.Liberty, the human rights organisation that is representing the Prettys, and the Voluntary