tbuckley/cabot-search huggingface dataset:
Abstract 456: Antiphospholipid Antibodies Promote Platelet Activation and Thrombosis by Inhibition of Platelet eNOS
Authors: Craig Morrell, AnneMarie Swaim, Tanika Martin, Guillermina Girardi, Jane E Salmon, Chieko Mineo, Phillip Shaul
Journal: Circulation (2007)

The antiphospholipid syndrome (APS) is an autoimmune systemic disorder characterized by the persistent presence of antiphospholipid antibodies (aPL Ab) and increased risk of thrombosis, coronary artery disease and myocardial infarction. Although platelets are known direct targets of aPL Ab action, the molecular basis of aPL Ab actions on platelets remains unclear. Platelet endothelial NO synthase (eNOS) is a key regulator of platelet function, with NO causing blunted activation. We therefore determined whether aPL Ab modulate platelet eNOS. Normal human IgG (NH IgG) and human IgG containing polyclonal aPL Ab were obtained from healthy individuals and APS patients, respectively, and purified using protein G-Sepharose chromatography. Using both human and mouse platelets, we found that aPL Ab increased agonist-induced platelet activation whereas NH IgG did not. In contrast to the enhanced activation by aPL Ab in platelets from wild-type mice, aPL Ab had no effect on platelets isolated from eNOS null mice. Pre-treatment of platelets with aPL Ab also inhibited insulin-mediated eNOS stimulation as evidenced by diminished cGMP production and DAF2 fluorescence. Receptor associated protein (RAP), an antagonist of ligand binding to members of the LDL receptor family, blocked aPL Ab-induced increases in platelet activation. RAP also prevented aPL Ab-mediated antagonism of platelet eNOS, indicating that aPL Ab signal through the platelet ApoER2â ϵ™ (LRP8) to attenuate eNOS activity. Furthermore, using intravital microscopy of the mouse mesenteric circulation, we demonstrated that platelets from wild-type mice treated with aPL Ab have increased rolling on a stimulated endothelium and a decreased time to thrombus formation in vivo versus platelets treated with NH IgG. In contrast, aPL Ab did not alter the in vivo function of platelets from eNOS null mice. These cumulative in vitro and in vivo findings demonstrate that aPL Ab antagonism of platelet eNOS through LDL receptor family member binding underlies aPL Ab-mediated thrombosis.
Long-term survival after multidisciplinary treatment of small-bowel neuroendocrine tumors with synchronous liver metastases. A single-institute experience.
Authors: Emilio Bertani, Nicola Fazio, Antonio Chiappa, Edoardo Botteri, Francesca Spada, Chiara Grana, Davide Ravizza, Laura Cossu, Guido Bonomo, Bruno Andreoni
Journal: Journal of Clinical Oncology (2013)

299 Background: Neuroendocrine tumors (NETs) that originate in the distal jejunum and ileum are commonly diagnosed in stage IV, with liver metastases in 50-75% of cases. The aim of this study was to ascertain the impact of surgery in a consecutive series of patients with small bowel NET and synchronous liver metastases treated at a single institute. Methods: Ninety-one patients managed between 1995 and 2011 were extracted from the institutional tumor registry. All patients had diagnosis by histology of small bowel NET and synchronous liver metastases. Results: Among the 91 patients 28 (30.8%) underwent primary tumor removal and liver metastases resection or intraoperative termal ablation (Group 1), 54 (59.3%) underwent resection of only the primary tumor (Group 2), and the remaining 9 (9.9%) did not receive any surgery (Group 3). After a median follow-up of 64 months an overall survival (OS) of 93.1%, 81.8% and 76.2% at 3, 5 and 8 years was registered for the whole group. Cancer-specific survival (CSS) was 93.1%, 83.3% and 77.6% at 3, 5 and 8 years, respectively. Five-years OS differed significantly according to the surgical approach (96.0% for Group 1 vs 79.8% for Group 2 vs 48.6% for Group 3, p=0.02). During the course of the illness octreotide was administered in 78 patients (85.7%), peptide receptor radiotherapy in 61 (67.0%), systemic chemotherapy in 21 (23.1%), hepatic artery embolization in 17 (18.7%), interferon in 11 (12.1%), molecular targeted agents in 2 (2.2%). For patients who underwent any surgery (Group 1 and Group 2) the multidisciplinary approach was associated with a better OS (85.7% vs 77.2% 5-years OS, p=0.04). In the multivariate analysis only age was associated with OS, HR: 1.05 (C. I.: 1.01-1.10). The results of CSS were comparable to those of OS. Conclusions: In this metastatic setting of small bowel NETs the 5 year OS was as high as 82% with a maximum benefit achievable for patients who had primary tumor resection and liver disease amenable to surgical or thermal ablation. However, the potential impact of age in prognosis should be carefully considered when choosing the treatment to be delivered in such patients.
TUBERCULAR INFECTION BY MILK.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tissue Economies
Authors: Laura Mamo
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HP0003 Intensive therapy of system variant juvenile rheumatoid artritis
Authors: TM Fomenko, GI Donov, IE Schahbazyan
Journal: Annals of the Rheumatic Diseases (2001)

<h3></h3> Combined plasmapheresis (PP) with methotrexate was used in 39 children aged 2–15 with severe system variant juvenile rheumatoid artritis. Juvenile rheumatoid artritis accomponied persistence infection and septic complication. PP was conducted every other day 5 times. After each PP followed by immunosupressants therapy (PIT) (bolus methylprednisolone, methotrexate). Total dose was at most 15 mg/week. Then patients received injections immunoglobulines every other day 3 times. Total dose immunoglobulines was 0,4–0,6 mg/kg. 12 patients had herpes infection. Before intensive therapy patients received zovirax. During first week by used intensive methods of therapy used to disappear basic indication of disease. After 2 weeks state of patients was stably and not required intensive therapy. 9 patients from 39 had remission about 12 months. These patients used intensive methods of therapy repeatedly. 12 patients had exacerbation a year later after intensive therapy. These patients received only basic therapy. 1 died 2 years after the end of the treatment. 17 patients developed complete remission in 16–36 months. All these patients received basic therapy (prednisolone, methotrexate).
The Wife
Authors: Bonnie Salomon
Journal: Annals of Internal Medicine (2001)

Ad Libitum3 April 2001The WifeBonnie Salomon, MDBonnie Salomon, MDDeerfield, IL 60015 (Salomon)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-7-200104030-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The burden of the man is gone.His wife is here to pick him up.Another night, another dawn she scours local ERsTo find him here, loaded with charm,Flirting with nurses half his age.Release forms flutter in her hands.She cannot bear the doctor's gaze.He sways like a boat with gin-soaked sails.She trails in his wake.Til we meet again, he waves.The doctor advises: observation … admission.She's observed enough. He admits nothing.His bed now vacant, a new shift on duty.All are pleased at his departure.Her head bowed, eyes fixed on the floor,Car keys wrapped in knuckles so whiteThey just might crack another night. Author, Article, and Disclosure InformationAffiliations: Deerfield, IL 60015 (Salomon)Corresponding Author: Bonnie Salomon, MD, 53 Crestview Drive, Deerfield, IL 60015. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 April 2001Volume 134, Issue 7Page: 593KeywordsInterleukins ePublished: 3 April 2001 Issue Published: 3 April 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Antihypertensive Agents
Authors: Edward D. Freis
Journal: New England Journal of Medicine (1962)

Sympathetic Blocking DrugsACCORDING to present evidence nor-epinephrine is manufactured and stored in specialized chromaffin cells and granules in many parts of the body. These stores are most numerous in the intestine and spleen but are also present in other organs, including the heart.1 The granules have been isolated from adrenergic nerves, where nor-epinephrine can be released both by nerve stimulation and by certain amines such as tyramine.2 In laboratory animals reserpine releases and depletes the catechol amine content of the brain,3 the heart and the adrenal medulla4 , 5 and the aortic wall.6 These and other recent observations have led to . . .
Hypothalamic stimulation and feline gastric mucosal cellular populations. Factors in the etiology of the stress ulcer
Authors: J. M. Pearl
Journal: JAMA (1966)

It has long been recognized clinically that intracranial abnormalities and peptic ulcer disease coexist more frequently than would be expected by chance.<sup>1</sup>Experimentally it is possible to induce peptic ulcers by destruction or stimulation of a number of cerebral sites.<sup>2</sup>Because of its role as an integrative center for autonomic function, the hypothalamus has received considerable attention from investigators interested in the etiology of the neurogenic or stress ulcer. Gross localization of differing autonomic functions to certain areas within the hypothalamus has been frequently described in several animal species.<sup>3</sup>Our experiments have emphasized the importance of the frequency and pulse duration of the stimulating current in eliciting a sympathetic or parasympathetic response. We find that stimulation of the anteromedial region of the hypothalamus with low frequency, brief duration pulses produces primarily a parasympathetic response while stimulation of the posteromedial region of the hypothalamus with longer duration, higher
THE RÔLE OF INSULIN IN CARBOHYDRATE METABOLISM
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genome-wide association study for alcohol-related cirrhosis identifies new risk loci in MARC1 and HNRNPUL1
Authors: Hamish Innes, Stephan Buch, Sharon Hutchinson, Neil Guha, Joanne Morling, Eleanor Barnes, William Irving, Ewan Forrest, Vincent Pedergnana, David Goldberg, Esther Aspinall, Stephen Barclay, Peter Hayes, John Dillon, Hans Dieter Nischalke, Philipp Lutz, Ulrich Spengler, Janett Fischer, Thomas Berg, Florian Eyer, Christian Datz, Sebastian Mueller, Teresa Peccerella, Astrid Marot, Pierre Deltenre, Michael Soyka, Andrew Mcquillin, Marsha Morgan, Jochen Hampe, Felix Stickel
Journal: Journal of Hepatology (2020)
Obstetrics.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Author Disclosures for Late-Breaking Abstracts
Authors: L3 Blaiss, L8 Chen, Andrew Nothing, L1 Ehl, Stephan Nothing, L1 Engelhardt, Karen Nothing, L1 Esham, Dana Nothing, L4 Fleischer, David Nothing, L1 Gautrin, Denyse Nothing, L8 Gawchik, Hong Kim, L1 Sook, Sang-Hoon Kim, Donald Leung, Ting Liang
Journal: Journal of Allergy and Clinical Immunology (2010)
Quadriceps Strength and Osteoarthritis Progression in Malaligned and Lax Knees
Authors: Leena Sharma, Dorothy D. Dunlop, Karen W. Hayes
Journal: Annals of Internal Medicine (2004)

Letters20 January 2004Quadriceps Strength and Osteoarthritis Progression in Malaligned and Lax KneesLeena Sharma, MD, Dorothy D. Dunlop, PhD, and Karen W. Hayes, PhDLeena Sharma, MDFrom Northwestern University, Chicago, IL 60611.Search for more papers by this author, Dorothy D. Dunlop, PhDFrom Northwestern University, Chicago, IL 60611.Search for more papers by this author, and Karen W. Hayes, PhDFrom Northwestern University, Chicago, IL 60611.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-2-200401200-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:To Dr. Judge, we respond that we too are concerned about errors in the description of our findings and their implications. Our study dealt with the relationship between strength and progression in osteoarthritic knees that were also malaligned or lax. Strength had no deleterious effect in more neutral or stable knees. Also, we stated that these results have no implications for aerobic exercise or physical activity in general. It was important to report our results, regardless of whether they match what has been believed (in the absence of data) about the effect of strength on disease progression in ... Author, Article, and Disclosure InformationAffiliations: From Northwestern University, Chicago, IL 60611. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoQuadriceps Strength and Osteoarthritis Progression in Malaligned and Lax Knees Leena Sharma , Dorothy D. Dunlop , September Cahue , Jing Song , and Karen W. Hayes Is a Strong Quadriceps Muscle Bad for a Patient with Knee Osteoarthritis? Leena Sharma , Dorothy D. Dunlop , and Karen W. Hayes Quadriceps Strength and Osteoarthritis Progression in Malaligned and Lax Knees James Judge Quadriceps Strength and Osteoarthritis Progression in Malaligned and Lax Knees Mary E. Moore Quadriceps Strength and Osteoarthritis Progression in Malaligned and Lax Knees David Riley Metrics Cited byKnee osteoarthritis pain and stretching exercises: a systematic review and meta-analysis 20 January 2004Volume 140, Issue 2Page: 150KeywordsAerobic exerciseBody mass indexBody weightExerciseKneesOsteoarthritis ePublished: 20 January 2004 Issue Published: 20 January 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A field study of the stress response syndrome. Young women after hysterectomy
Authors: N. B. Kaltreider
Journal: JAMA (1979)

The symptom pattern previously delineated as the stress response syndrome in a mental health setting was hypothesized to be useful in conceptualizing reactions to a traumatic event in a nonpsychiatric patient population. The experience of loss resulting from nonelective hysterectomy for benign disease in women of childbearing age was selected as a relevant field study model. Twenty-eight women were studied one year after hysterectomy, using extensive psychological interviewing by women clinicians and experiential rating scales. Twelve subjects had a mild stress response syndrome, and five subjects had a serious level of intrusive and avoidant symptoms. Increasing severity of response was associated with persisting child-wish, deterioration in sexual functioning, and change in self-concept. Women who did well postoperatively generally had no future wish for children and were actively committed to achievement outside of the home. (<i>JAMA</i>242:1499-1503, 1979)
Gastroenterology
Authors: Joseph B. Kirsner, John E. Dooley, George E. Scott, Sumner C. Kraft
Journal: Annual Review of Medicine (1959)

Postpartum depression (PPD) is common, disabling, and treatable. The strongest risk factor is a history of mood or anxiety disorder, especially having active symptoms during pregnancy. As PPD is one of the most common complications of childbirth, it is ...Read More
Abstract 3988: Identifying prognostic biomarkers of hepatocellular carcinoma by weighted gene coexpression network analysis
Authors: Yi Bai, Junyu Long, Jianzhen Lin, Xu Yang, Dongxu Wang, Xiaobo Yang, Xinting Sang, Jiahui Liu, Haitao Zhao
Journal: Cancer Research (2019)

Abstract Purpose: Exploring the molecular mechanisms of prognosis in patients with hepatocellular carcinoma (HCC) could assist in identifying novel biomarkers for effective therapy against this deadly disease. Hence, this study was designed to determine the prognostic biomarkers of HCC and to investigate potential mechanisms. Experimental Design: The RNA-Seq data as well as clinical data were downloaded from The Cancer Genome Atlas (TCGA) database, aiming at identifying differentially expressed genes (DEGs) between nontumorous tissues and HCC. Then, weighted gene coexpression network analysis (WGCNA) was performed for determining significant modules associated with overall survival (OS). Results: The mRNA expression profiles from 374 HCC patients in TCGA were included to determine 3270 DEGs. Then, WGCNA was carried out on the 3270 DEGs, and 10 coexpressed gene modules were determined. Pearson’s correlation analysis revealed that the turquoise module significantly positively correlated with OS and the blue module significantly negatively correlated with OS, followed by seven hub genes with high connectivity were identified in these two modules. Based on the Kaplan-Meier (K-M) survival curves and receiver operating characteristic (ROC) curves, the seven hub genes could predict prognosis for patients with HCC well, and the results were validated by GSE54236 dataset contained 78 HCC patients. Additionally, the univariate and multivariate Cox regression analyses showed that the seven hub genes were independent prognostic factors for patients with HCC. Conclusions: In conclusion, the current results provide novel insights into the prognostic biomarkers of HCC, which may contribute to the development of molecular targeted therapy for HCC. Citation Format: Yi Bai, Junyu Long, Jianzhen Lin, Xu Yang, Dongxu Wang, Xiaobo Yang, Xinting Sang, Jiahui Liu, Haitao Zhao. Identifying prognostic biomarkers of hepatocellular carcinoma by weighted gene coexpression network analysis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3988.
Poor-law Report of the Provincial Medical and Surgical Association.--1841
Journal: BMJ (1841)

§ 30.Your committec have thus, at considerable length, submitted to the Association the result of their examination of the commissioners' Report and Ap- pendix, the whole of which (although necessarily par- tial and(I defcctive in its testimony) is sufficient to prove that its juthors and the boards of guardians, with a few honourable exceptions, continue eitlher inable to comprehend, or unwilling practically to ac- lknowledge, the nature of medical duties and respon- sililities, no less than thlle claims of the sick poor.At the very time when the documents, which have now been considered, were in preparation at Somerset House, or in course of publication, your committee received many important communications from pro- vinlcial practitioners.The information thus supplied, in addition to that collected by other medical associations,* or con- taiiied in thle public joumals, clearly showed, what inideed the commissioners confirmed-viz., that thc abuses complained of in 1838, not only still existed, but were almost unabated.§ 31.Two or three flagrant instances of the ini- quitous system pursued with respect to medical ap- pointments, are selected for notice in this Report.