tbuckley/cabot-search huggingface dataset:
Long-term Clinical Outcomes and Mediating Mechanistic Effects of Bariatric Surgery on Adipokines and Gastrointestinal Hormone Secretion: The First 10-year Long Longitudinal and Case-cohort Study
Authors: Alexander Kokkinos, Dimitrios Tsilingiris, Stamatia Simati, Angeliki M. Angelidi, Konstantinos Stefanakis, Nikolaos Tentolouris, Bhanu Karla, Ajay Kumar, Ioanna A. Anastasiou, Andreas Alexandrou, Christos S. Mantzoros
Journal: Metabolism (2023)
Advancing Type 2 Diabetes Therapy with iGlarLixi in Older People: Pooled Analysis of Four Randomized Controlled Trials
Authors: Medha Munshi, Robert Ritzel, Irene Hramiak, Gagik Galstyan, Elisabeth Souhami, Terry Dex, Lydie Melas-Melt, Julio Rosenstock
Journal: Metabolism (2023)
Pegozafermin for the Treatment of Severe Hypertriglyceridemia: A Randomized, Double-blind, Placebo-controlled Phase 2 Study (ENTRIGUE STUDY)
Authors: Deepak L. Bhatt, Harold E. Bays, Michael Miller, Teresa Parli, Shibao Feng, Lulu Sterling, Cynthia L. Hartsfield, Germaine D. Agollah, Hank Mansbach, John J.P. Kastelein
Journal: Metabolism (2023)
Growth Differentiation Factor 15 (GDF-15) Levels Associated with the Presence and Severity of NAFLD
Authors: Laura Valenzuela-Vallejo, Pavlina Chrysafi, Valentina Guatibonza-García, Chrysoula Boutari, Melih Agraz, Margery A. Connelly, George V. Papatheodoridis, Ornella Verrastroe, Geltrude Mingrone, Christos S. Mantzoros
Journal: Metabolism (2023)
Association Between Processed and Ultra-processed Food Intake and Cardiovascular Disease and its Risk Factors in Patients with Type 2 Diabetes
Authors: Renata Boscaini David, Cristina Pavinatto, Daniê Hahn Weber, Joana Rogowski Souza Dos Santos, Caroline Fraga Bassotto, Paula Horn Zelmanovitz, Alice Hinda Lichtenstein, Themis Zelmanovitz
Journal: Metabolism (2023)
Pegozafermin Led to Significant Metabolic Benefits, in Addition to Robust Beneficial Effects on the Liver, in an Open-label Cohort of a Phase 1b/2a Study in Subjects with Non-alcoholic Steatohepatitis (NASH)
Authors: Naim Alkhouri, Rohit Loomba, Juan P. Frias, Shibao Feng, Leo Tseng, Germaine D. Agollah, Hank Mansbach, Maya Margalit, Cynthia L. Hartsfield, Stephen Harrison
Journal: Metabolism (2023)
Expression Profiling of Blood-based Inflammatory (pro/anti) Biomarkers Including HSP27, CD14 and CRP in Insulin Resistance Type-2 Diabetic Patients with CVD Complication
Authors: M. Zafar, M.R. Mirza, I.R. Malik, F.R. Awan, M.H. Ovais, Z. Ali
Journal: Metabolism (2023)
EVALUATION OF 1-HOUR POST LOAD GLUCOSE LEVELS, THE METABOLIC SYNDROME AND FINDRISC SCORES IN THE PREDICTION OF T2DM IN PATIENTS WITH IMPAIRED FASTING GLUCOSE
Authors: Juan Carlos Lizarzaburu-Robles, Alonso Garro-Mendiola, María Lazo-Porras, Flor Vento, Óscar Lorenzo
Journal: Metabolism (2023)
The Effect of Coenzyme Q10 Supplementation on Insulin Resistance in Overweight/Obese Women with Polycystic Ovary Syndrome
Authors: Yethindra Vityala, Tugolbai Tagaev, Jun Yi Lim, Krishna Priya Kanteti, Abhijith Krishna Bajith Kumar, Karthik Nattava, Sadiq Ali Meer
Journal: Metabolism (2023)
Pegozafermin Improved Liver Histology, Liver-related Non-invasive Tests (NITs) and Metabolic Profiles in an Open-label Cohort of a Phase 1b/2a Study in Subjects with Non-alcoholic Steatohepatitis
Authors: Rohit Loomba, Naim Alkhouri, Shibao Feng, Leo Tseng, Germaine D. Agollah, Hank Mansbach, Maya Margalit, Cynthia L. Hartsfield, Stephen A. Harrison
Journal: Metabolism (2023)
Sclerostin loop3-LRP4 Interaction Required by Sclerostin for Lipid and Glucose Metabolism Impairment in Adipocyte
Authors: Hewen Jiang, Dijie Li, Luyao Wang, Ning Zhang, Sifan Yu, Huarui Zhang, Jin Liu, Daqing Ma, Aiping Lu, Hui Sheng, Bao-ting Zhang, Ge Zhang
Journal: Metabolism (2023)
GLP1-RA AND SGLT2-I. Comparison of the Effectiveness of the Newer Antidiabetic Medication in Everyday Practice. The Experience of a Diaberic Outpatient Clinic of a Tertiary Hospital of Athens
Authors: Ioannis Gastouiniotis, Alexandra Theodoropoulou, Foteini Kyriakou, Marina Noutsou, Anastasia Thanopoulou
Journal: Metabolism (2023)
Using Healthcare Claims Data and Machine Learning to Identify Health Disparities for Individuals with Diagnosed and Undiagnosed Familial Hypercholesterolemia
Authors: Zahid Ahmad, Chao Xing, Amit Khera, Chun-Yuan Huang, Eric J. Brandt, Diane E. MacDougall, Catherine D. Ahmed, Mary P. McGowan, Hilly Paige, Katherine A. Wilemon, Kelly D. Myers
Journal: Metabolism (2023)
Underuse of Medicines in Romanian Elderly Population Based on START v.2, 2015 Criteria
Authors: Valentina Buda, Andreea Prelipcean, Olivia Dalleur, Maria Suciu, Liana Suciu, Simona Buda, Mirabela Romanescu, Diana Mailat, Teodora Mateoc, Angele Dohou, Carmen Cristescu, Lucian Petrescu, Octavian Cretu, Minodora Andor
Journal: Metabolism (2023)
Raised Intracranial Pressure in Three Children with Cystic Fibrosis Receiving Elexacaftor-Tezacaftor-Ivacaftor Modulator Therapy
Authors: Kevin W. Southern, Jürg Barben, Stephen Goldring, Rachel Kneen, Suzanne Southward, Yashasvi Rajeev, Jane C. Davies, Andrew Bush
Journal: American Journal of Respiratory and Critical Care Medicine (2023)

"Raised Intracranial Pressure in Three Children with Cystic Fibrosis Receiving Elexacaftor-Tezacaftor-Ivacaftor Modulator Therapy." American Journal of Respiratory and Critical Care Medicine, 208(1), pp. 103–105
Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures
Authors: Arno R. Bourgonje, Sergio Andreu-Sánchez, Thomas Vogl, Shixian Hu, Arnau Vich Vila, Ranko Gacesa, Sigal Leviatan, Alexander Kurilshikov, Shelley Klompus, Iris N. Kalka, Hendrik M. van Dullemen, Adina Weinberger, Marijn C. Visschedijk, Eleonora A.M. Festen, Klaas Nico Faber, Cisca Wijmenga, Gerard Dijkstra, Eran Segal, Jingyuan Fu, Alexandra Zhernakova, Rinse K. Weersma
Journal: Immunity (2023)
Corrigendum to “In search of viable SARS-CoV-2 in the tear film: a prospective clinical study in hospitalized symptomatic patients” [Clin Microbiol Infect 28(8) (2022 Aug) 1172–1173]
Authors: Laura Leysen, Heleen Delbeke, Stefanie Desmet, Pieter-Paul Schauwvlieghe, Piet Maes, Gauthier Blanckaert, Emiel Matthys, Marie Joossens, Ingele Casteels
Journal: Clinical Microbiology and Infection (2023)
The Role of Prophylactic Antibiotics for Patients With Severe Alcohol-Related Hepatitis
Authors: Ewan Forrest, William Bernal
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: Nivolumab Plus Cabozantinib vs Sunitinib for First-Line Treatment of Advanced Renal Cell Carcinoma (aRCC): 3-Year Follow-Up From the Phase 3 CheckMate 9 ER Trial
Journal: Journal of Clinical Oncology (2023)

46 (34-58) 56 (49-64) 28 (21-35) 41 (29-54) 10 (4-20) 53 (46-59) 23 (18-29
Recruitment of epitope-specific T cell clones with a low-avidity threshold supports efficacy against mutational escape upon re-infection
Authors: Adrian Straub, Simon Grassmann, Sebastian Jarosch, Lena Richter, Philipp Hilgendorf, Monika Hammel, Karolin I. Wagner, Veit R. Buchholz, Kilian Schober, Dirk H. Busch
Journal: Immunity (2023)
A Labor of Love
Authors: Rebecca Kowaloff
Journal: Journal of Clinical Oncology (2023)

It is natural to want to avoid the sadness and powerlessness that come with losing, especially a young patient to a ravaging cancer. But there is gratification for the clinician and a deep sense of connection and support on the part of the patient and their family when we instead lean into and share those feelings, bringing our human self to the relationship when it feels that our medical self can offer so little.
Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire
Authors: Sergio Andreu-Sánchez, Arno R. Bourgonje, Thomas Vogl, Alexander Kurilshikov, Sigal Leviatan, Angel J. Ruiz-Moreno, Shixian Hu, Trishla Sinha, Arnau Vich Vila, Shelley Klompus, Iris N. Kalka, Karina de Leeuw, Suzanne Arends, Iris Jonkers, Sebo Withoff, Elisabeth Brouwer, Adina Weinberger, Cisca Wijmenga, Eran Segal, Rinse K. Weersma, Jingyuan Fu, Alexandra Zhernakova
Journal: Immunity (2023)
The Future of Clinical Trials in Idiopathic Pulmonary Fibrosis
Authors: Anna J. Podolanczuk, Luca Richeldi, Fernando J. Martinez
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intrinsically determined turnover underlies broad heterogeneity in plasma-cell lifespan
Authors: Marcus James Robinson, Zhoujie Ding, Mark R. Dowling, Danika L. Hill, Rosela H. Webster, Craig McKenzie, Catherine Pitt, Kristy O’Donnell, Jesse Mulder, Erica Brodie, Philip D. Hodgkin, Nick C. Wong, Isaak Quast, David M. Tarlinton
Journal: Immunity (2023)
Beneficial effects of upadacitinib on alopecia areata associated with atopic dermatitis: A multicenter retrospective study
Authors: Andrea Chiricozzi, Anna Balato, Gabriella Fabbrocini, Lucia Di Nardo, Graziella Babino, Mariateresa Rossi, Maria Esposito, Alberto Maria Bertoldi, Giampiero Girolomoni, Alessio Gambardella, Flaminia Antonelli, Cataldo Patruno, Maria Concetta Fargnoli, Giuseppe Argenziano, Ketty Peris
Journal: Journal of the American Academy of Dermatology (2023)
Intestinal Candida albicans overgrowth in IgA deficiency
Authors: Alicia Moreno-Sabater, Delphine Sterlin, Lejla Imamovic, Fabienne Bon, Anne-Cecile Normand, Cecile Gonnin, Marianne Gazzano, Merieme Bensalah, Karim Dorgham, Elyes Ben Salah, Aniss Acherar, Christophe Parizot, Virginie Rigourd, Hervé Begue, Frederic Dalle, Claude Bachmeyer, Christophe Hennequin, Hans Yssel, Marion Malphettes, Claire Fieschi, Jehane Fadlallah, Guy Gorochov
Journal: Journal of Allergy and Clinical Immunology (2023)

Secretory IgA interacts with commensal bacteria, but its impact on human mycobiota ecology has not been widely explored. In particular, whether human IgA-deficiency is associated with gut fungal dysbiosis remains unknown. Our goal was to study the impact of IgA on gut mycobiota ecology. The Fungi-Flow method was used to characterize fecal, systemic, and maternal IgA, IgM, and IgG responses against 14 representative fungal strains (yeast/spores or hyphae forms) in healthy donors (HDs) (n = 34, 31, and 20, respectively) and to also compare gut mycobiota opsonization by secretory antibodies in HDs (n = 28) and patients with selective IgA deficiency (SIgAd) (n = 12). Stool mycobiota composition was determined by internal transcribed spacer gene sequencing in HDs (n = 23) and patients with SIgAd (n = 17). Circulating CD4+ T-cell cytokine secretion profiles were determined by intracellular staining. The impact of secretory IgA, purified from breast milk (n = 9), on Candidaalbicans growth and intestinal Caco-2 cell invasion was tested in vitro. Homeostatic IgA binds commensal fungi with a body fluid-selective pattern of recognition. In patients with SIgAd, fungal gut ecology is preserved by compensatory IgM binding to commensal fungi. Gut Calbicans overgrowth nevertheless occurs in this condition but only in clinically symptomatic patients with decreased TH17/TH22 T-cell responses. Indeed, secretory IgA can reduce in vitro budding and invasion of intestinal cells by Calbicans and therefore exert control on this pathobiont. IgA has a selective impact on Calbicans ecology to preserve fungal-host mutualism.
TB granuloma: CD30 co-stimulation for CD4+ T cell co-operation
Authors: Abigail R. Gress, Tyler D. Bold
Journal: The Journal of Experimental Medicine (2023)

Tuberculosis granuloma T cells express an array of mediators including the CD30 co-stimulatory receptor and its ligand, CD153. CD4 T effector cells require signals through CD30, potentially provided co-operatively by other T cells, to completely differentiate and protect against disease (Foreman et al., 2023. J. Exp. Med.https://doi.org/10.1084/jem.20222090).
Behavioral Interventions for Children and Adults with Tic Disorder
Authors: Douglas W. Woods, Michael B. Himle, Jordan T. Stiede, Brandon X. Pitts
Journal: Annual Review of Clinical Psychology (2023)

Over the past decade, behavioral interventions have become increasingly recognized and recommended as effective first-line therapies for treating individuals with tic disorders. In this article, we describe a basic theoretical and conceptual framework through which the reader can understand the application of these interventions for treating tics. The three primary behavioral interventions for tics with the strongest empirical support (habit reversal, Comprehensive Behavioral Intervention for Tics, and exposure and response prevention) are described. Research on the efficacy and effectiveness of these treatments is summarized along with a discussion of the research evaluating the delivery of these treatments in different formats and modalities. The article closes with a review of the possible mechanisms of change underlying behavioral interventions for tics and areas for future research.
Machine Learning and the Digital Measurement of Psychological Health
Authors: Isaac R. Galatzer-Levy, Jukka-Pekka Onnela
Journal: Annual Review of Clinical Psychology (2023)

Since its inception, the discipline of psychology has utilized empirical epistemology and mathematical methodologies to infer psychological functioning from direct observation. As new challenges and technological opportunities emerge, scientists are once again challenged to define measurement paradigms for psychological health and illness that solve novel problems and capitalize on new technological opportunities. In this review, we discuss the theoretical foundations of and scientific advances in remote sensor technology and machine learning models as they are applied to quantify psychological functioning, draw clinical inferences, and chart new directions in treatment.
A Clinical Psychologist Who Studies Alcohol
Authors: Kenneth J. Sher
Journal: Annual Review of Clinical Psychology (2023)

In this article, I describe why I believe the study of alcohol use and its consequences is a rich and rewarding area of scholarly activity that touches on multiple disciplines in the life sciences, the behavioral sciences, and the humanities. I then detail the circuitous path I took to become an alcohol researcher and the various challenges I encountered when starting up my research program at the University of Missouri. A major theme of my journey has been my good fortune encountering generous, brilliant scholars who took an interest in me and my career and who helped guide and assist me over the course of my career. I also highlight selected, other professional activities I've been involved in, focusing on editorial work, quality assurance, and governance of professional societies. While the focus is on my training and work as a psychologist, the overarching theme is the interpersonal context that nurtures careers.
Baseline Serum Prostate-specific Antigen Value Predicts the Risk of Subsequent Prostate Cancer Death—Results from the Norwegian Prostate Cancer Consortium
Authors: Johan Bjerner, Ola Bratt, Kirsti Aas, Peter C. Albertsen, Sophie D. Fosså, Rune Kvåle, Hans Lilja, Christoph Müller, Stig Müller, Andreas Stensvold, Owen Thomas, Oluf D. Røe, Andrew Vickers, Jochen Walz, Sigrid V. Carlsson, Jan Oldenburg
Journal: European Urology (2023)
Potential of nanoemulsions for accelerated wound healing: innovative strategies
Authors: Jatin Chhabra, Hitesh Chopra, Rakesh Pahwa, Neha Raina, Karan Wadhwa, Swati Saini, Poonam Negi, Madhu Gupta, Inderbir Singh, Harish Dureja, Talha Bin Emran
Journal: International Journal of Surgery (2023)

Wounds represent various significant health concerns for patients and also contribute major costs to healthcare systems. Wound healing comprises of overlapped and various coordinated steps such as homeostasis, inflammation, proliferation, and remodeling. In response to the failure of many strategies in delivering intended results including wound closure, fluid loss control, and exhibiting properties such as durability, targeted delivery, accelerated action, along with histocompatibility, numerous nanotechnological advances have been introduced. To understand the magnitude of wound therapy, this systematic and updated review discussing the effectiveness of nanoemulsions has been undertaken. This review portrays mechanisms associated with wound healing, factors for delayed wound healing, and various technologies utilized to treat wounds effectively. While many strategies are available, nanoemulsions have attracted the tremendous attention of scientists globally for the research in wound therapy due to their long-term thermodynamic stability and bioavailability. Nanoemulsions not only aid in tissue repair, but are also considered as an excellent delivery system for various synthetic and natural actives. Nanotechnology provides several pivotal benefits in wound healing, including improved skin permeation, controlled release, and stimulation of fibroblast cell proliferation. The significant role of nanoemulsions in improved wound healing along with their preparation techniques has also been highlighted with special emphasis on mechanistic insights. This article illustrates recent research advancements for the utilization of nanoemulsions in wound treatment. An adequate literature search has been conducted using the keywords ‘Nanoemulsions in wound healing’, ‘Wound therapy and nanoemulsions’, ‘Herbal actives in wound therapy’, ‘Natural oils and wounds treatment’ etc., from PubMed, Science Direct, and Google Scholar databases. Referred and original publications in the English language accessed till April 2022 has been included, whereas nonEnglish language papers, unpublished data, and nonoriginal papers were excluded from the study.
Current state of the use of antibiotic prophylactics in cardiac surgery – correspondence
Authors: Toufik Abdul-Rahman, Murad O. Omran, Olabode Ekerin, Shankhaneel Ghosh, Wireko A. Awuah
Journal: International Journal of Surgery (2023)

Abdul-Rahman, Toufika,; Omran, Murad Othmanb; Ekerin, Olabodec; Ghosh, Shankhaneeld; Awuah, Wireko Andrewa Author Information
Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis
Authors: Kyu-Won Cho, Mark Andrade, Seongho Bae, Sangsung Kim, Jin Eyun Kim, Er Yearn Jang, Sangho Lee, Ahsan Husain, Roy L. Sutliff, John W. Calvert, Changwon Park, Young-sup Yoon
Journal: Circulation (2023)

Background: Shortly after birth, cardiomyocytes exit the cell cycle and cease proliferation. At present, the regulatory mechanisms for this loss of proliferative capacity are poorly understood. CBX7 (chromobox 7), a polycomb group (PcG) protein, regulates the cell cycle, but its role in cardiomyocyte proliferation is unknown. Methods: We profiled CBX7 expression in the mouse hearts through quantitative real-time polymerase chain reaction, Western blotting, and immunohistochemistry. We overexpressed CBX7 in neonatal mouse cardiomyocytes through adenoviral transduction. We knocked down CBX7 by using constitutive and inducible conditional knockout mice ( Tnnt2-Cre;Cbx7 fl/+ and Myh6-MCM;Cbx7 fl/fl , respectively). We measured cardiomyocyte proliferation by immunostaining of proliferation markers such as Ki67, phospho-histone 3, and cyclin B1. To examine the role of CBX7 in cardiac regeneration, we used neonatal cardiac apical resection and adult myocardial infarction models. We examined the mechanism of CBX7-mediated repression of cardiomyocyte proliferation through coimmunoprecipitation, mass spectrometry, and other molecular techniques. Results: We explored Cbx7 expression in the heart and found that mRNA expression abruptly increased after birth and was sustained throughout adulthood. Overexpression of CBX7 through adenoviral transduction reduced proliferation of neonatal cardiomyocytes and promoted their multinucleation. On the other hand, genetic inactivation of Cbx7 increased proliferation of cardiomyocytes and impeded cardiac maturation during postnatal heart growth. Genetic ablation of Cbx7 promoted regeneration of neonatal and adult injured hearts. Mechanistically, CBX7 interacted with TARDBP (TAR DNA-binding protein 43) and positively regulated its downstream target, RBM38 (RNA Binding Motif Protein 38), in a TARDBP-dependent manner. Overexpression of RBM38 inhibited the proliferation of CBX7-depleted neonatal cardiomyocytes. Conclusions: Our results demonstrate that CBX7 directs the cell cycle exit of cardiomyocytes during the postnatal period by regulating its downstream targets TARDBP and RBM38. This is the first study to demonstrate the role of CBX7 in regulation of cardiomyocyte proliferation, and CBX7 could be an important target for cardiac regeneration.