tbuckley/cabot-search huggingface dataset:
Ultraviolet B radiation-induced JPH203-loaded keratinocyte extracellular vesicles exert etiological interventions for psoriasis therapy
Authors: Xinyu Jiang, Zewei Jiang, Shuqi Huang, Pengfei Mao, Linyi Zhang, Minghui Wang, Jinyao Ye, Lining Sun, Meng Sun, Ruijie Lu, Tuyue Sun, Huixiang Sheng, Xinyu Zhao, Aimin Cai, Xinhua Ma, Qing Yao, Guangyong Lin, Ruijie Chen, Longfa Kou
Journal: Journal of Controlled Release (2023)
Four-Factor Prothrombin Complex Concentrate for Patients With Trauma
Authors: Chia-Hao Hsu, Pei-Hsi Chou, Nin-Chieh Hsu
Journal: JAMA (2023)

To the Editor We have some concerns about the recent study1 that showed that early administration of 4-factor prothrombin complex concentrate (4F-PCC) had no significant benefit in reduction of 24-hour blood product consumption in patients with severe trauma who were at risk of massive transfusion.
Juvenile Sonata
Authors: Elmo Frickman
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antimicrobial polymer-loaded hydrogels for the topical treatment of multidrug-resistant wound biofilm infections
Authors: Jessa Marie V. Makabenta, Ahmed Nabawy, Aritra Nath Chattopadhyay, Taewon Jeon, Jungmi Park, Pui Chi Lo, Stas Nosovitski, Rui Huang, Cheng-Hsuan Li, Mingdi Jiang, Vincent M. Rotello
Journal: Journal of Controlled Release (2023)
Four-Factor Prothrombin Complex Concentrate for Patients With Trauma
Authors: Tomohiko Sato, Kotaro Kida, Shigeki Miyata
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immortal Time Bias Possibly Affecting Fludrocortisone−Hydrocortisone Findings
Authors: John Karlsson Valik, Anders Ternhag, Pontus Nauclér
Journal: JAMA Internal Medicine (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Reproductive Factors and Endometrial Cancer Risk Among Women
Authors: Ryoko Katagiri, Motoki Iwasaki, Sarah Krull Abe, Md. Rashedul Islam, Md. Shafiur Rahman, Eiko Saito, Melissa A. Merritt, Ji-Yeob Choi, Aesun Shin, Norie Sawada, Akiko Tamakoshi, Woon-Puay Koh, Ritsu Sakata, Ichiro Tsuji, Jeongseon Kim, Chisato Nagata, Sue K. Park, Sun-Seog Kweon, Xiao-Ou Shu, Yu-Tang Gao, Shoichiro Tsugane, Takashi Kimura, Jian-Min Yuan, Seiki Kanemura, Yukai Lu, Yumi Sugawara, Keiko Wada, Min-Ho Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang
Journal: JAMA Network Open (2023)

Despite evidence of an association between reproductive factors and endometrial cancer risk, prospective studies have been conducted mainly in non-Asian countries.To assess the association between reproductive factors, such as number of deliveries, age at menarche, or menopause, and endometrial cancer risk.This cohort study used pooled individual data from 13 prospective cohort studies conducted between 1963 and 2014 in the Asia Cohort Consortium. Participants were Asian women. Data analysis was conducted from September 2019 to April 2023.Reproductive factors were assessed using a questionnaire in each cohort.The main outcome was time to incidence of endometrial cancer. A Cox proportional hazards model was used to calculate hazard ratios (HRs) and 95% CIs.A total of 1005 endometrial cancer cases were detected among 332 625 women (mean [SD] age, 54.3 [10.4] years) during a mean (SD) of 16.5 (6.4) years of follow-up. Increasing number of deliveries was associated with a decreased endometrial cancer risk in a dose-response manner (≥5 deliveries vs nulliparous [reference]: HR, 0.37; 95% CI, 0.26-0.53; P for trend < .001). Compared with menarche at younger than 13 years, menarche at 17 years or older had an HR of 0.64 (95% CI, 0.48-0.86; P for trend < .001). Late menopause (age ≥55 years) showed an HR of 2.84 (95% CI, 1.78-4.55; P for trend < .001) compared with the youngest age category for menopause (<45 years). Age at first delivery, hormone therapy, and breastfeeding were not associated with endometrial cancer risk.This large pooled study of individual participant data found that late menarche, early menopause, and a higher number of deliveries were significantly associated with a lower risk of endometrial cancer. These convincing results from Asian prospective studies add to the growing body of evidence for the association between reproductive factors and endometrial cancer.
Tissue Engineering of JAK Inhibitor‐Loaded Hierarchically Biomimetic Nanostructural Scaffold Targeting Cellular Senescence for Aged Bone Defect Repair and Bone Remolding
Authors: Shi Liu, Xinlin Jia, Jina Hao, Dapeng Zhang, Shengchao Yang, Bin Dai, Yuanqing Mao, Yongsheng Li
Journal: Advanced Healthcare Materials (2023)

Cell senescence or apoptosis contributes to self-failure and functional loss in specialized cells, leading to incapacity of the body to repair specific damages. Senescent bone marrow mesenchymal stem cells (BMSCs) lose their proliferative abilities and secrete senescence-associated secretory phenotype (SASP), hindering their participation in bone defect repair. Hence, the effective suppression of cell senescence is crucial to restore the self-repair capacity of body to treat bone defects. Since the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway is associated with SASP secretion, herein, a new strategy is proposed to inhibit this pathway to suppress SASP secretion and enhance osteoblast activity based on a novel hierarchically biomimetic nanostructural electrospun scaffold with JAK inhibitors (JAKi, Ruxolitinib) loaded. As validated by in vitro and in vivo experiments, the JAKi loaded scaffold reduces SASP expression effectively and alleviates senescent cell burden, creating a pro-regeneration microenvironment that enhances osteoblast function and mineralization activity as well as rejuvenating the bone repair capacity. These findings offer insights into the regulatory role of cellular senescence in bone aging and provide a new and effective strategy to treat age-related bone defects by delivery of JAKi to locally aging bone defect sites.
<scp>Long‐Term</scp> Efficacy and Safety of Canakinumab in Patients With Tumor Necrosis Factor Receptor–Associated Periodic Syndrome: Results From a Phase <scp>III</scp> Trial
Authors: Marco Gattorno, Laura Obici, Inmaculada Calvo Penadés, Tilmann Kallinich, Susanne Benseler, Elise Dekker, Jérémy Lévy, Fabrizio De Benedetti, Helen Lachmann
Journal: Arthritis & Rheumatology (2023)

We aimed at assessing efficacy, safety, and tolerability of canakinumab in patients with tumor necrosis factor receptor-associated periodic syndrome (TRAPS) during a 72-week long-term, open-label extension of the CLUSTER study.
Publisher Correction: Glymphatic influx and clearance are accelerated by neurovascular coupling
Authors: Stephanie Holstein-Rønsbo, Yiming Gan, Michael J. Giannetto, Martin Kaag Rasmussen, Björn Sigurdsson, Felix Ralf Michael Beinlich, Laura Rose, Verena Untiet, Lauren M. Hablitz, Douglas H. Kelley, Maiken Nedergaard
Journal: Nature Neuroscience (2023)
Allostatic Load in Children and Adolescents: A Systematic Review
Authors: Marcella Lucente, Jenny Guidi
Journal: Psychotherapy and Psychosomatics (2023)

Introduction: The concept of allostatic load encompasses the cumulative effects of both ordinary daily life events as well as major challenges, and also includes related health-damaging behavior. Allostatic overload ensues when environmental challenges exceed the individual’s ability to cope. Identification of allostatic load is carried out through the use of biomarkers and clinimetric criteria. Studies are increasingly reported on allostatic load in younger populations, yet a systematic review is missing. Objective: The aim of the present systematic review was to summarize the current knowledge on allostatic load/overload among children and adolescents. Methods: PubMed, PsycINFO, Web of Science, and the Cochrane Library were searched from inception to April 2023. A manual search of the literature was also performed. We considered only studies in which allostatic load or overload were adequately described and assessed in either clinical or non-clinical populations younger than 18 years. Results: A total of 38 original investigations were included in this systematic review. Studies reported an association between allostatic load and sociodemographic characteristics (e.g., poverty, ethnicity, perceived discrimination, adverse childhood experiences) and environmental factors, as well as consequences of allostatic load on both physical and mental health among children and adolescents. Conclusions: The findings indicate that greater allostatic load is associated with poorer health outcomes in both clinical and non-clinical pediatric populations, with possible enduring effects. The results support the clinical utility of the transdiagnostic identification of allostatic load and overload in children and adolescents across a variety of settings, with a number of potential clinical implications.
Clinician Response to Patient Medication Prices Displayed in the Electronic Health Record
Authors: Anna D. Sinaiko, Caroline E. Sloan, Mark J. Soto, Olivia Zhao, Chen-Tan Lin, Foster R. Goss
Journal: JAMA Internal Medicine (2023)

This cross-sectional study examines whether clinicians changed their medication orders after seeing the patient’s out-of-pocket drug costs in the electronic health record.
The mesencephalic locomotor region recruits V2a reticulospinal neurons to drive forward locomotion in larval zebrafish
Authors: Martin Carbo-Tano, Mathilde Lapoix, Xinyu Jia, Olivier Thouvenin, Marco Pascucci, François Auclair, Feng B. Quan, Shahad Albadri, Vernie Aguda, Younes Farouj, Elizabeth M. C. Hillman, Ruben Portugues, Filippo Del Bene, Tod R. Thiele, Réjean Dubuc, Claire Wyart
Journal: Nature Neuroscience (2023)

Abstract The mesencephalic locomotor region (MLR) is a brain stem area whose stimulation triggers graded forward locomotion. How MLR neurons recruit downstream vsx2 + (V2a) reticulospinal neurons (RSNs) is poorly understood. Here, to overcome this challenge, we uncovered the locus of MLR in transparent larval zebrafish and show that the MLR locus is distinct from the nucleus of the medial longitudinal fasciculus. MLR stimulations reliably elicit forward locomotion of controlled duration and frequency. MLR neurons recruit V2a RSNs via projections onto somata in pontine and retropontine areas, and onto dendrites in the medulla. High-speed volumetric imaging of neuronal activity reveals that strongly MLR-coupled RSNs are active for steering or forward swimming, whereas weakly MLR-coupled medullary RSNs encode the duration and frequency of the forward component. Our study demonstrates how MLR neurons recruit specific V2a RSNs to control the kinematics of forward locomotion and suggests conservation of the motor functions of V2a RSNs across vertebrates.
Real-Time Benefit Tools Must Be Designed to Serve Both Clinicians and Patients
Authors: Isabel Ostrer, Tracy Y. Wang
Journal: JAMA Internal Medicine (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
A synthetic delivery vector for mucosal vaccination
Authors: Anne Billet, Justine Hadjerci, Thi Tran, Pascal Kessler, Jonathan Ulmer, Gilles Mourier, Marine Ghazarian, Anthony Gonzalez, Robert Thai, Pauline Urquia, Anne-Cécile Van Baelen, Annalisa Meola, Ignacio Fernandez, Stéphanie Deville-Foillard, Ewan MacDonald, Léa Paolini, Frédéric Schmidt, Félix A. Rey, Michael S. Kay, Eric Tartour, Denis Servent, Ludger Johannes
Journal: Biomaterials (2023)
Imbalanced lipid homeostasis caused by membrane αKlotho deficiency contributes to the acute kidney injury to chronic kidney disease transition
Authors: Yue Wang, Li Ran, Qigang Lan, Weinian Liao, Liting Wang, Yaqin Wang, Jiachuan Xiong, Fugang Li, Wenrui Yu, Yan Li, Yinghui Huang, Ting He, Junping Wang, Jinghong Zhao, Ke Yang
Journal: Kidney International (2023)

After acute kidney injury (AKI), renal tubular epithelial cells (RTECs) are pathologically characterized by intracellular lipid droplet (LD) accumulation, which are involved in RTEC injury and kidney fibrosis. However, its pathogenesis remains incompletely understood. The protein, αKlotho, primarily expressed in RTECs, is well known as an anti-aging hormone wielding versatile functions, and its membrane form predominantly acts as a co-receptor for fibroblast growth factor 23. Here, we discovered a connection between membrane αKlotho and intracellular LDs in RTECs. Fluorescent fatty acid (FA) pulse-chase assays showed that membrane αKlotho deficiency in RTECs, as seen in αKlotho homozygous mutated (kl/kl) mice or in mice with ischemia-reperfusion injury (IRI)-induced AKI, inhibited FA mobilization from LDs by impairing adipose triglyceride lipase (ATGL)-mediated lipolysis and lipophagy. This resulted in LD accumulation and FA underutilization. IRI-induced alterations were more striking in αKlotho deficiency. Mechanistically, membrane αKlotho deficiency promoted E3 ligase peroxin2 binding to ubiquitin-conjugating enzyme E2 D2, resulting in ubiquitin-mediated degradation of ATGL which is a common molecular basis for lipolysis and lipophagy. Overexpression of αKlotho rescued FA mobilization by preventing ATGL ubiquitination, thereby lessening LD accumulation and fibrosis after AKI. This suggests that membrane αKlotho is indispensable for the maintenance of lipid homeostasis in RTECs. Thus, our study identified αKlotho as a critical regulator of lipid turnover and homeostasis in AKI, providing a viable strategy for preventing tubular injury and the AKI-to-chronic kidney disease transition.
Real-world results of autologous stem cell transplantation in newly diagnosed multiple myeloma: a report from the Canadian Myeloma Research Group database
Authors: Julie Côté, Richard LeBlanc, Hira Mian, Michael P. Chu, Arleigh McCurdy, Esther Masih-Khan, Jiandong Su, Victor H. Jimenez-Zepeda, Kevin Song, Martha Louzada, Darrell White, Michael Sebag, Anthony Reiman, Julie Stakiw, Rami Kotb, Debra Bergstrom, Muhammad Aslam, Rayan Kaedbey, Christopher P. Venner, Engin Gul, Donna Reece
Journal: Blood Cancer Journal (2023)

Abstract Autologous stem cell transplant (ASCT) remains an important option for eligible multiple myeloma (MM) patients as part of initial therapy. Using the Canadian Myeloma Research Group (CMRG) national database, we examined the details and outcomes of ASCT performed as first-line therapy in eligible Canadian MM patients between 2007 to 2021. We included 3821 patients with 72% receiving CyBorD induction and 2061 patients receiving maintenance, consisting of lenalidomide +/- steroids in 78.3%. The median PFS and OS for patients given a single ASCT were 35.4 and 126 months. Those receiving a second induction regimen had significantly inferior outcomes, although when maintenance was used, results were comparable regardless of the number of induction regimens administered (median PFS 55.3 vs 51.1 months [ p = 0.11]; median OS 158.6 vs not yet reached [ p = 0.13]). Consolidation patients had a longer median PFS (55.3 vs 34.4 months [ p = 0.001]), but no significant gain in median OS ( p = 0.065). Patients who received lenalidomide-based maintenance experienced a median PFS of 53.7 months and OS of 159 months. In the multivariable analysis, use of any type of maintenance therapy vs no maintenance was associated with a lower risk of progression (HR 0.52 (95% CI 0.47-0.57)) and death (HR 0.58 (95% CI 0.51-0.67)). This real-world study demonstrates that, overall, first-line treatment sequence in transplant-eligible patients produces a median OS of ≥10 years. It also highlights the contribution of post-ASCT maintenance, particularly lenalidomide given until progression.
Looking for a balance between visual and automatic sleep scoring
Authors: Vincenzo Muto, Christian Berthomier
Journal: npj Digital Medicine (2023)

Sleep recordings are visually classified in stages by experts in the field, based on consensus international criteria. This procedure is expensive and time-consuming. Automatic sleep scoring systems have, progressively over the years, demonstrated good levels of accuracy. Although the performance of these algorithms is believed to be high, however, there remains widespread skepticism in their daily use in clinical and scientific practice. In this comment to a recent publication of NPJ Digital Medicine, we express the reasons why we think the sleep expert should remain the central pivot in the pendulum between visual and automatic methodology, trying to find a new balance in the scientific debate.
The Role of 99mTc‐Sestamibi Single-photon Emission Computed Tomography/Computed Tomography in the Diagnostic Pathway for Renal Masses: A Systematic Review and Meta‐analysis
Authors: Giuseppe Basile, Giuseppe Fallara, Paolo Verri, Alessandro Uleri, Arturo Chiti, Luigi Gianolli, Gino Pepe, Alessandro Tedde, Ferran Algaba, Angelo Territo, Francesco Sanguedolce, Alessandro Larcher, Andrea Gallioli, Joan Palou, Francesco Montorsi, Umberto Capitanio, Alberto Breda
Journal: European Urology (2023)
Cell-free DNA chromosome copy number variations predict outcomes in plasma cell myeloma
Authors: Wanting Qiang, Lina Jin, Tiancheng Luo, Yanchun Jia, Jing Lu, Jin Liu, Haiyan He, Ziliang Qian, Sridurga Mithraprabhu, Yang Liang, Robert Peter Gale, Xia Tao, Depei Wu, Juan Du
Journal: Blood Cancer Journal (2023)
MiR-9-1 controls osteoblastic regulation of lymphopoiesis
Authors: Yongguang Zhang, Danfeng Lin, Yongwei Zheng, Yuhong Chen, Mei Yu, Dongya Cui, Miaohui Huang, Xinlin Su, Yong Sun, Yabing Chen, Zhijian Qian, Karen-Sue Carlson, Renren Wen, Demin Wang
Journal: Leukemia (2023)
Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations
Authors: Yueqiong Ni, Lingling Qian, Sara Leal Siliceo, Xiaoxue Long, Emmanouil Nychas, Yan Liu, Marsena Jasiel Ismaiah, Howell Leung, Lei Zhang, Qiongmei Gao, Qian Wu, Ying Zhang, Xi Jia, Shuangbo Liu, Rui Yuan, Lina Zhou, Xiaolin Wang, Qi Li, Yueliang Zhao, Hani El-Nezami, Aimin Xu, Guowang Xu, Huating Li, Gianni Panagiotou, Weiping Jia
Journal: Cell Metabolism (2023)