tbuckley/cabot-search huggingface dataset:
Silk Fibroin Encapsulated Icariin Nanoparticles Mitigate Bisphenol A‐Induced Spermatogenesis Dysfunction
Authors: Chunyan Fang, Yaodong You, Fan Luo, Zheng Li, Yifeng Shen, Fangyue Wang, Jingyi Zhang, Ren‐You Gan, Yulong Ye
Journal: Advanced Healthcare Materials (2023)

Bisphenol A (BPA) is a prevalent endocrine disruptor found in natural environments. Exposure to BPA has been associated with male infertility. The natural phytochemical icariin (ICA) has demonstrated significant promise for the treatment of male infertility. However, its effectiveness is limited due to its low bioavailability, poor water solubility, and insufficient targeting abilities. Herein, novel nanoparticles are generated from the natural silk fibroin, which are used to load ICA. The efficient drug delivery system (ICA-SNPs) result in significantly focused drug distribution to spermatogonium, enhancing the anti-infertility properties of ICA, and can effectively mitigate spermatogenesis dysfunction induced by BPA, control serum sex hormone levels, and enhance testicular ultrastructure. Additionally, the ICA-SNPs restore spermatogenesis dysfunction primarily via the hormone biosynthesis, spermatogonium meiosis process, and glycerophospholipid metabolism.
Effectiveness of the live zoster vaccine during the 10 years following vaccination: real world cohort study using electronic health records
Authors: Nicola P Klein, Joan Bartlett, Bruce Fireman, Morgan A Marks, John Hansen, Edwin Lewis, Laurie Aukes, Patricia Saddier
Journal: BMJ (2023)

Abstract Objectives To assess the effectiveness of live zoster vaccine during more than 10 years after vaccination; and to describe methods for ascertaining vaccine effectiveness in the context of waning. Design Real world cohort study using electronic health records. Setting Kaiser Permanente Northern California, an integrated healthcare delivery system in the US, 1 January 2007 to 31 December 2018. Population More than 1.5 million people aged 50 years and older followed for almost 9.4 million person years. Main outcome measure Vaccine effectiveness in preventing herpes zoster, postherpetic neuralgia, herpes zoster ophthalmicus, and admission to hospital for herpes zoster was assessed. Change in vaccine effectiveness by time since vaccination was examined using Cox regression with a calendar timeline. Time varying indicators were specified for each interval of time since vaccination (30 days to less than one year, one to less than two years, etc) and adjusted for covariates. Results Of 1 505 647 people, 507 444 (34%) were vaccinated with live zoster vaccine. Among 75 135 incident herpes zoster cases, 4982 (7%) developed postherpetic neuralgia, 4439 (6%) had herpes zoster ophthalmicus, and 556 (0.7%) were admitted to hospital for herpes zoster. For each outcome, vaccine effectiveness was highest in the first year after vaccination and decreased substantially over time. Against herpes zoster, vaccine effectiveness waned from 67% (95% confidence interval 65% to 69%) in the first year to 15% (5% to 24%) after 10 years. Against postherpetic neuralgia, vaccine effectiveness waned from 83% (78% to 87%) to 41% (17% to 59%) after 10 years. Against herpes zoster ophthalmicus, vaccine effectiveness waned from 71% (63% to 76%) to 29% (18% to 39%) during five to less than eight years. Against admission to hospital for herpes zoster, vaccine effectiveness waned from 90% (67% to 97%) to 53% (25% to 70%) during five to less than eight years. Across all follow-up time, overall vaccine effectiveness was 46% (45% to 47%) against herpes zoster, 62% (59% to 65%) against postherpetic neuralgia, 45% (40% to 49%) against herpes zoster ophthalmicus, and 66% (55% to 74%) against admission to hospital for herpes zoster. Conclusions Live zoster vaccine was effective initially. Vaccine effectiveness waned substantially yet some protection remained 10 years after vaccination. After 10 years, protection was low against herpes zoster but higher against postherpetic neuralgia. Trial registration ClinicalTrials.gov number NCT01600079 ; EU PAS register number EUPAS17502
Endoscopic management of complex colorectal anastomotic leakage with a pelvic collection and rectovaginal fistula
Authors: Laurent Monino, Radu Bachmann, Daniel Leonard, Christophe Remue, Etienne Danse, Alex Kartheuser, Tom Moreels
Journal: Endoscopy (2023)

The adverse event rate after colorectal surgery is up to 20%, with anastomotic leakage representing 2.9%–15.3% of events [1]. Surgical management consists of external drainage of the collection or challenging redo surgery. Endoscopic vacuum therapy (EVT) is based on the application of negative pressure on tissues in order to drain pus and favor granulation tissue [2]. The clinical success rate of EVT for the closure of collections is around 70%–80% [3] [4] [5]. We report the case of a patient with complex colorectal anastomotic leakage with a large presacral abscess and rectovaginal fistula, who was successfully treated with endoscopic drainage along with EVT.
An olsalazine nanoneedle-embedded inulin hydrogel reshapes intestinal homeostasis in inflammatory bowel disease
Authors: Zhuangzhuang Zhang, Yang Pan, Zhaoyuan Guo, Xi Fan, Qingqing Pan, Wenxia Gao, Kui Luo, Yuji Pu, Bin He
Journal: Bioactive Materials (2023)

Inflammatory bowel disease (IBD) is a chronic and refractory condition characterized by disrupted epithelial barrier, dysregulated immune balance, and altered gut microbiota. Nano-enabled interventions for restoring gut homeostasis have the potential to alleviate inflammation in IBD. Herein, we developed a combination of olsalazine (Olsa)-based nanoneedles and microbiota-regulating inulin gel to reshape intestinal homeostasis and relieve inflammation. The Olsa-derived nanoneedles exhibited reactive oxygen species scavenging ability and anti-inflammatory effects in lipopolysaccharide-simulated macrophages. The composite of nanoneedles and inulin gel (Cu2(Olsa)/Gel) displayed a macroporous structure, improved bio-adhesion, and enhanced colon retention after oral administration. Mechanistically, the composite effectively downregulated pro-inflammatory cytokine levels and promoted epithelial barrier repair through anti-inflammatory and antioxidant therapies, resulting in significant alleviation of colitis in three animal models of IBD. Furthermore, analysis of gut microbiota revealed that Cu2(Olsa)/Gel treatment increased the diversity of intestinal microflora and decreased the relative abundance of pathogenic bacteria such as Proteobacteria. Overall, this study provides a self-delivering nanodrug and dietary fiber hydrogel composite for IBD therapy, offering an efficient approach to restore intestinal homeostasis.
Corrigendum to “Bilayer small-diameter vascular grafts with on-demand NO and H2S release capabilities” [Bioact. Mater. 31 (2024) 38-52]
Authors: Pengfei Li, Fubang Liang, Lijuan Wang, Dawei Jin, Yushuang Shang, Xu Liu, Jie Zhang, Yu Sun, Yanjun Pan, Jiang Yuan, Jian Shen, Meng Yin
Journal: Bioactive Materials (2023)

[This corrects the article DOI: 10.1016/j.bioactmat.2023.07.020.].
Exosomes derived from impaired liver aggravate alveolar bone loss via shuttle of Fasn in type 2 diabetes mellitus
Authors: Jiani Liu, Geng Dou, Wanmin Zhao, Ji'an Hu, Zhiwei Jiang, Wenzhe Wang, Hanzhe Wang, Shiyu Liu, Yan Jin, Yimin Zhao, Qianming Chen, Bei Li
Journal: Bioactive Materials (2023)

Type 2 diabetes mellitus (T2DM) exacerbates irreversible bone loss in periodontitis, but the mechanism of impaired bone regeneration caused by the abnormal metabolic process of T2DM remains unclear. Exosomes are regarded as the critical mediator in diabetic impairment of regeneration via organ or tissue communication. Here, we find that abnormally elevated exosomes derived from metabolically impaired liver in T2DM are significantly enriched in the periodontal region and induced pyroptosis of periodontal ligament cells (PDLCs). Mechanistically, fatty acid synthase (Fasn), the main differentially expressed molecule in diabetic exosomes results in ectopic fatty acid synthesis in PDLCs and activates the cleavage of gasdermin D. Depletion of liver Fasn effectively mitigates pyroptosis of PDLCs and alleviates bone loss. Our findings elucidate the mechanism of exacerbated bone loss in diabetic periodontitis and reveal the exosome-mediated organ communication in the "liver-bone" axis, which shed light on the prevention and treatment of diabetic bone disorders in the future.
Poliovirus receptor–based chimeric antigen receptor T cells combined with NK-92 cells exert potent activity against glioblastoma
Authors: Changqing Pan, You Zhai, Chen Wang, Zhiyi Liao, Di Wang, Mingchen Yu, Fan Wu, Yiyun Yin, Zhongfang Shi, Guanzhang Li, Tao Jiang, Wei Zhang
Journal: JNCI Journal of the National Cancer Institute (2023)

Abstract Background Poliovirus receptor interacts with 3 receptors: T-cell immunoglobulin immunoreceptor tyrosine-based inhibitory motif, CD96, and DNAX accessory molecule 1, which are predominantly expressed on T cells and natural killer (NK) cells. Many solid tumors, including IDH wild-type glioblastoma, have been reported to overexpress poliovirus receptor, and this overexpression is associated with poor prognosis. However, there are no preclinical or clinical trials investigating the use of cell-based immunotherapies targeting poliovirus receptor in IDH wild-type glioblastoma. Methods We analyzed poliovirus receptor expression in transcriptome sequencing databases and specimens from IDH wild-type glioblastoma patients. We developed poliovirus receptor targeting chimeric antigen receptor T cells using lentivirus. The antitumor activity of chimeric antigen receptor T cells was demonstrated in patient-derived glioma stem cells, intracranial and subcutaneous mouse xenograft models. Results We verified poliovirus receptor expression in primary glioma stem cells, surgical specimens from IDH wild-type glioblastoma patients, and organoids. Accordingly, we developed poliovirus receptor–based second-generation chimeric antigen receptor T cells. The antitumor activity of chimeric antigen receptor T cells was demonstrated in glioma stem cells and xenograft models. Tumor recurrence occurred in intracranial xenograft models because of antigen loss. The combinational therapy of tyrosine-based inhibitory motif extracellular domain–based chimeric antigen receptor T cells and NK-92 cells markedly suppressed tumor recurrence and prolonged survival. Conclusions Poliovirus receptor–based chimeric antigen receptor T cells were capable of killing glioma stem cells and suppressing tumor recurrence when combined with NK-92 cells.
Revisiting the standard blueprint for biomarker development to address emerging cancer early detection technologies
Authors: Ruth Etzioni, Roman Gulati, Christos Patriotis, Carolyn Rutter, Yingye Zheng, Sudhir Srivastava, Ziding Feng
Journal: JNCI Journal of the National Cancer Institute (2023)

Novel liquid biopsy technologies are creating a watershed moment in cancer early detection. Evidence supporting population screening is nascent, but a rush to market the new tests is prompting cancer early detection researchers to revisit the standard blueprint that the Early Detection Research Network established to evaluate novel screening biomarkers. In this commentary, we review the Early Detection Research Network's Phases of Biomarker Development (PBD) for rigorous evaluation of novel early detection biomarkers and discuss both hazards and opportunities involved in expedited evaluation. According to the PBD, for a biomarker-based test to be considered for population screening, 1) test sensitivity in a prospective screening setting must be adequate, 2) the shift to early curable stages must be meaningful, and 3) any stage shift must translate into clinically significant mortality benefit. In the past, determining mortality benefit has required lengthy randomized screening trials, but interest is growing in expedited trial designs with shorter-term endpoints. Whether and how best to use such endpoints in a manner that retains the rigor of the PBD remains to be determined. We discuss how computational disease modeling can be harnessed to learn about screening impact and meet the needs of the moment.
Constricting Life Space and Likelihood of Neurodegenerative Disease in Community-Dwelling Older Men
Authors: Meredith A. Bock, Tina Hoang, Peggy Cawthon, Dawn C. Mackey, Sheena Patel, Teresa A. Hillier, Kristine Yaffe
Journal: JAMA Network Open (2023)

Importance Life space is a measure of the frequency, range, and independence of movement through the environment. There is increasing interest in life space as a holistic measure of function in older adults, but the association between change in life space and incident neurodegenerative disease is unknown. Objective To evaluate the association between change in life space and cognitive decline or incident neurodegenerative disease over 7 years among community-dwelling older men. Design, Setting, and Participants In this cohort study, logistic regression analyses were used to examine the association of baseline and change in life space with change in cognition unadjusted and adjusted for demographics, cardiovascular risk factors, depression, gait speed, and physical activity. Mixed linear effects models were used to evaluate the association between change in life space and change in cognition. Men were recruited from 6 US sites to participate in a prospective, community-based cohort study of aging and followed-up from 2007 to 2014. Individuals with prevalent dementia or Parkinson disease (PD) at baseline were excluded. Data were analyzed from May 2022 to September 2023. Exposure Life space, assessed using the University of Alabama at Birmingham Life Space Assessment and divided into tertiles. Main Outcomes and Measures Participants completed the Modified Mini-Mental State (3MS) Test, and Trail-Making Test Part B at baseline and 7 years later. At follow-up, participants were asked about a new physician diagnosis of dementia and PD. Results A total of 1684 men (mean [SD] age, 77.1 [4.2] years) were recruited and over 7 years of follow-up, 80 men (4.8%) developed dementia and 23 men (1.4%) developed PD. Mean (SD) life space score was 92.9 (18.7) points and mean (SD) change was −9.9 (22.3) points over follow up. In the adjusted model, each 1-SD decrement in life space was associated with increased odds of dementia (odds ratio [OR], 1.59; 95% CI, 1.28-1.98) but not PD (OR, 1.48; 95% CI, 0.97-2.25). For each 1-SD decrement in life space, men worsened by 20.6 (95% CI, 19.8-21.1) seconds in their Trails B score ( P &amp;amp;lt; .001) and declined by 1.2 (95% CI, 1.0-1.3) points in their 3MS score ( P &amp;amp;lt; .001) over 7 years. Conclusions and Relevance In this study of 1684 men followed up over 7 years, change in life space was associated with faster cognitive decline and increased likelihood of neurodegenerative illness. Future studies should examine the role of clinician assessments or wearable electronics in tracking life space in older adults at risk of cognitive decline and neurodegenerative illness.
Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis
Authors: Marcella Birtele, Ashley Del Dosso, Tiantian Xu, Tuan Nguyen, Brent Wilkinson, Negar Hosseini, Sarah Nguyen, Jean-Paul Urenda, Gavin Knight, Camilo Rojas, Ilse Flores, Alexander Atamian, Roger Moore, Ritin Sharma, Patrick Pirrotte, Randolph S Ashton, Eric J Huang, Gavin Rumbaugh, Marcelo P Coba, Giorgia Quadrato
Journal: Nature Neuroscience (2023)
IgE to common food allergens is associated with cardiovascular mortality in the National Health and Examination Survey and the Multi-Ethnic Study of Atherosclerosis
Authors: Corinne Keet, Emily C. McGowan, David Jacobs, Wendy S. Post, Nathan E. Richards, Lisa J. Workman, Thomas A.E. Platts-Mills, Ani Manichaikul, Jeffrey M. Wilson
Journal: Journal of Allergy and Clinical Immunology (2023)
Population structure of Salmonella enterica Typhi in Harare, Zimbabwe (2012–19) before typhoid conjugate vaccine roll-out: a genomic epidemiology study
Authors: Gaetan Thilliez, Tapfumanei Mashe, Blessmore V Chaibva, Valerie Robertson, Matt Bawn, Andrew Tarupiwa, Faustinos T Takawira, Marleen M Kock, Stanley Midzi, Lusubilo W Mwamakamba, Jorge Matheu, Agnes Juru, Robert A Kingsley, Marthie M Ehlers
Journal: The Lancet Microbe (2023)

The continued emergence of Salmonella enterica serovar Typhi, with ever increasing antimicrobial resistance, necessitates the use of vaccines in endemic countries. A typhoid fever outbreak in Harare, Zimbabwe, in 2018 from a multidrug resistant S Typhi with additional resistance to ciprofloxacin was the catalyst for the introduction of a typhoid conjugate vaccine programme. We aimed to investigate the emergence and evolution of antimicrobial resistance of endemic S Typhi in Zimbabwe and to determine the population structure, gene flux, and sequence polymorphisms of strains isolated before a typhoid conjugate vaccine programme to provide a baseline for future evaluation of the effect of the vaccination programme.
Optimising follow-up strategy based on cytology and human papillomavirus after fertility-sparing surgery for early stage cervical cancer: a nationwide, population-based, retrospective cohort study
Authors: Teska N Schuurman, Mirte Schaafsma, Kaylee H To, Viola M J Verhoef, Karolina Sikorska, Albert G Siebers, Hans H B Wenzel, Maaike C G Bleeker, Eva Maria Roes, Ronald P Zweemer, Peggy J de Vos van Steenwijk, Refika Yigit, Jogchum J Beltman, Petra L M Zusterzeel, Christianne A R Lok, Ruud L M Bekkers, Constantijne H Mom, Nienke E van Trommel
Journal: The Lancet Oncology (2023)
Impact of discontinuing oxytocin in active labour on neonatal morbidity: an open-label, multicentre, randomised trial
Authors: Aude Girault, Loïc Sentilhes, Raoul Desbrière, Paul Berveiller, Diane Korb, Charline Bertholdt, Julie Carrara, Norbert Winer, Eric Verspyck, Eric Boudier, Tiphaine Barjat, Gilles Levy, Georges Emmanuel Roth, Gilles Kayem, Mona Massoud, Caroline Bohec, Paul Guerby, Elie Azria, Julie Blanc, Hélène Heckenroth, Jessica Rousseau, Charles Garabedian, Camille Le Ray
Journal: The Lancet (2023)
The significance and risk of biliary sphincterotomy in pancreatic endotherapy: a case report
Authors: A. Papaefthymiou, A. Boichenko, G. Johnson
Journal: Endoscopy (2023)

Aims In patients with chronic pancreatitis (CP) who have an indication for endoscopic retrograde pancreatography(ERP), biliary sphincterotomy is not routinely recommended. The aim of this report is to present a case where biliary sphincterotomy could prevent post ERP cholangitis.
Balloon dilations in anastomotic stricture after total gastrectomy and esophagectomy with colon interpostition after caustic ingestion
Authors: S. Katsila, K. Dimopoulou, K. Kakounis, N. Sfougkatakis, V. Xiromeritou
Journal: Endoscopy (2023)

Aims The ingestion of caustic liquids may have complications such as strictures, gastric outflow obstruction and malignancy or perforation and death.
Double endoscope technique for EUS-guided gastroenteroanastomosis using lumen-apposing metal stents (LAMS) in clinical practice
Authors: A. Sanchez-Yague, R. Rivera-Irigoin, A. Gonzalez Canoniga, C. Lopez Muñoz, A. Perez-Aisa
Journal: Endoscopy (2023)

Aims To review a technique using two endoscopes and instillation of water to create a EUS-guided gastroenteroanastomosis with a LAMS in a single step.
Tip of an Iceberg
Authors: P. N. Desai, K. Mayank, P. Chintan, P. Ritesh
Journal: Endoscopy (2023)

Abstract Text 65 year old, Intermittent dysphagia, Multiple co-morbidities, CECT Abdomen and upper GI Endoscopy- A 2 cm submucosal tumour just below GE Junction with no lymphnodes. STER planned. Short submucosal tunnel amde in lwer esophagus. Tumor isolated. With further dissection atleast three extensions of the tumor in differnet directions noted and entire tumor in shape of an "S" was dissected. Haemostasis secured and mucosal incision closed. Endoscopic view can be deceptive submucosal lesions. Leiomyomas can be multilobed. STER is ideal for esophageal and GE junction SMT's.
The impact of a multidisciplinary team evaluation on the diagnosis and management of acute and chronic pancreatitis in a tertiary referral center
Authors: G. Lauri, M. Tacelli, G. Belfiori, D. Palumbo, F. Aleotti, M. Lanzillotta, R. Ponz de Leon Pisani, N. Bina, G. Dell'Anna, P. Zaccari, G. Vanella, L. Archibugi, G. Balzano, M. C. Petrone, G. Rossi, D. Tamburrino, A. Mariani, C. Doglioni, E. Della Torre, F. De Cobelli, M. Falconi, P. G. Arcidiacono, S. Crippa, G. Capurso
Journal: Endoscopy (2023)

Aims Describe the experience of a Multidisciplinary team meetings (MTM) tertiary referral center for pancreatic diseases for the management of acute and chronic pancreatitis (AP/CP).
Neoplasia Characterisation in IBD Colon: Can a Generic Colon CADx Algorithm Work in Characterising Polyps in an IBD Colon?
Authors: K. Siggens, H. Htet, M. Abdelrahim, P. Bhandari
Journal: Endoscopy (2023)

Aims Although polyps in IBD colons are morpholoigcally similar to those found in a non-IBD colons, there are a number of additional lesions seen as a result of inflammation, such as pseudo-polyps, inflammatory polyps and regenerative mucosa and even expert endoscopists struggle with optical diagnosis. Computer aided diagnosis (CADx) could improve lesion characterisation in this cohort of patients but a dedicated CADx algorithm has yet to be developed. Here we assess the performance of an existing generic colon CADx algorithm on lesion characterisation in IBD patients.
ERCP with the disposable duodenoscope aScopeDuodeno in routine clinical practice
Authors: E. Leventi, M. Mewes, A. Genthner, L. Welsch, A. Eickhoff
Journal: Endoscopy (2023)

Aims Bacterial colonizsation of reuseable duodenoscopes has been linked to healthcare-associated infections and was extensively discussed in the recent years as a potential risk for patients after ERCP. Therefore, disposable duodenoscopes were developed to eliminate the risk of cross-contamination. We evaluated the safety and efficacy of the single-use duodenoscope aScopeDuodeno(Ambu A/S, Denmark) in routine clinical practice.
Timing of endoscopy in patients with elevated lactate levels and acute upper gastrointestinal bleeding
Authors: G. ALLO, D. Gülcicegi, J. Gillessen, P. Kasper, S. H. Chon, T. Goeser, M. Bürger
Journal: Endoscopy (2023)

Aims While current guidelines recommend endoscopy within 24 hours in case of acute upper gastrointestinal bleeding (AUGIB), the precise timing remains an issue of debate. Lactate is an established parameter for risk stratification in a variety of medical emergencies and could identify critically ill patients, who may benefit from urgent endoscopy.
Contrast Enhanced-EUS and FNB of a rare mediastinal mass: a case report of mediastinal Schwannoma
Authors: L. Dario, Q. Dario, I. Tarantino, A. Bertani, L. Barresi, G.E. M. Rizzo, L. Carrozza, M. Traina
Journal: Endoscopy (2023)

Aims Contrast-Enhanced Endoscopic Ultrasonography (CE-EUS)-guided fine needle biopsy (FNB) is an important minimally invasive tool for diagnosis of mediastinal masses.
Vacumm therapy as rescue treatment for uncontrollable sepsis after endovascular treatment of aertoesophageal fistula
Authors: A. Lira, F. Junquera, S. Machlab, L. Hernandez, J. Vives, V. Puig-Diví, E. Martinez-Bauer
Journal: Endoscopy (2023)

Aims To prove the usefulness of vacuum therapy in the treatment of uncontrolled sepsis and the repair of esophageal gap due to AEF. Aortoesophageal fistula (AEF) is a life threatening disease due to massive gastrointestinal bleeding. Thoracic endovascular aortic repair (TEVAR) is the standard of care since achieves hemostasia. However, mortality is very high and is associated to sepsis secondary to mediastinitis.