tbuckley/cabot-search huggingface dataset:
Efficacy of oral versus long-acting antipsychotic treatment in patients with early-phase schizophrenia in Europe and Israel: a large-scale, open-label, randomised trial (EULAST)
Authors: Inge Winter-van Rossum, Mark Weiser, Silvana Galderisi, Stefan Leucht, Istvan Bitter, Birte Glenthøj, Alkomiet Hasan, Jurjen Luykx, Marina Kupchik, Georg Psota, Paola Rocca, Nikos Stefanis, Alexander Teitelbaum, Mor Bar Haim, Claudia Leucht, Georg Kemmler, Timo Schurr, Michael Davidson, René S Kahn, W Wolfgang Fleischhacker, René Sylvain Kahn, Walter Wolfgang Fleischhacker, Michael Davidson, Inge Winter-van Rossum, Mark Weiser, Jurjen Luykx, Alkomiet Hasan, Monica Mosescu, Silvana Galderisi, Marina Kupchik, Nikos Stefanis, Alexander Teitelbaum, Paola Rocca, Georg Psota, George Umoh, Istvan Bitter, Lucho Hranov, Alex Hofer, Joachim Cordes, Ramin Nilforooshan, Julio Bobes, Solveig Klebo Reitan, Manuel Morrens, Aurel Nirestean, John Geddes, Benedicto Crespo Faccorro, Marcin Olajossy, Alessandro Rossi, Erik Johnsen, Csekey László, Adela Ciobanu, Peter Haddad, Igor Oife, Miquel Bernardo, Rodicutza Stan, Marek Jarema, Dan Rujescu, Libor Ustohal, Neil Mayfield, Paola Dazzan, Avi Valevski, Jan Libiger, Richard Köhler, Pavel Mohr, Sofia Pappa, Petros Drosos, Thomas Barnes, Esther DeClercq, Elias Wagner, Paola Bucci, Armida Mucci, Yaacov Rabinowitz, Adam Adamopoulous, Benjamin Draiman, Cristiana Montemagni, Manfred Greslechner, Hannah Herlihy, Csilla Bolyos, Christian Schmidt-Kraepelin, Jessica TRUE, Leticia Alvarez Garcia, Berit Walla, Bernhard Sabbe, Lucaks Emese, Sarah Mather, Nikodem Skoczen, Serena Parnanzone, Jill Bjarke, Krisztina Karácsonyi, Steve Lankshear, Marina Garriga, Adam Wichniak, Heidi Baumbach, Timo Schurr, Leonie Willebrands, Lyliana Nasib, Cynthia Okhuijsen-Pfeifer, Elianne Huijsman
Journal: The Lancet Psychiatry (2023)
OA01.09 Adjuvant Osimertinib in Resected EGFR-Mutated Stage IB–IIIA Non-Small Cell Lung Cancer: Updated ADAURA Results
Authors: R.S. Herbst, Y.-L. Wu, C. Grohe, T. John, M. Majem, J. Wang, T. Kato, J.W. Goldman, S.-W. Kim, C.-J. Yu, H.V. Vu, G. Mukhametshina, C. Akewanlop, F. de Marinis, F.A. Shepherd, D. Urban, M. Stachowiak, A. Bolanos, X. Huang, M. Tsuboi
Journal: Journal of Thoracic Oncology (2023)
OA01.07 Sunvozertinib in NSCLC Patients with EGFR Exon20 Insertion Mutations
Authors: L. Bazhenova, J. Chih-Hsin Yang, M. Wang, P. Mitchell, D. Ross Camidge, J. Fang, W. Nian, C.-H. Chiu, J. Zhou, Y. Zhao, W.-C. Su, T.-Y. Yang, V.W. Zhu, M. Millward, Y. Fan, W.-T. Huang, Y. Cheng, L. Jiang, L. Zheng, P.A. Janne
Journal: Journal of Thoracic Oncology (2023)
COVID-19 lateral flow IgG seropositivity and serum neutralising antibody responses after primary and booster vaccinations in Chile: a cross-sectional study
Authors: Denis Sauré, Miguel O'Ryan, Juan Pablo Torres, Marcela Zuñiga, Ricardo Soto-Rifo, Fernando Valiente-Echeverría, Aracelly Gaete-Argel, Ignasi Neira, Vicente Saavedra, Mónica L Acevedo, Carmen Archila, Fernando Acuña, Manuel Rain, Leonardo J Basso
Journal: The Lancet Microbe (2023)
OA01.05 Three-year Outcomes per PD-L1 Status and Continued Cemiplimab Beyond Progression + Chemotherapy: EMPOWER-Lung 1
Authors: M.C. Garassino, S. Kilickap, M. Özgüroğlu, A. Sezer, M. Gumus, I. Bondarenko, M. Gogishvili, M. Nechaeva, M. Schenker, I. Cicin, H.G. Fuang, Y. Kulyaba, M. Dvorkin, K. Zyuhal, R.-I. Scheusan, X. He, M. Kaul, E. Okoye, Y. Li, S. Li, J.-F. Pouliot, F. Seebach, I. Lowy, G. Gullo, P. Rietschel
Journal: Journal of Thoracic Oncology (2023)
Efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients hospitalised with COVID-19 (COVASP): a pragmatic, cluster-randomised, non-inferiority trial
Authors: Justin Z Chen, Holly L Hoang, Maryna Yaskina, Dima Kabbani, Karen E Doucette, Stephanie W Smith, Cecilia Lau, Jackson Stewart, Shahileen Remtulla, Karen Zurek, Morgan Schultz, Hiromi Koriyama-McKenzie, Carlos Cervera
Journal: The Lancet Infectious Diseases (2023)
Emicizumab in people with moderate or mild haemophilia A (HAVEN 6): a multicentre, open-label, single-arm, phase 3 study
Authors: Claude Négrier, Johnny Mahlangu, Michaela Lehle, Pratima Chowdary, Olivier Catalani, Ronald J Bernardi, Víctor Jiménez-Yuste, Benjamin M Beckermann, Christophe Schmitt, Giuliana Ventriglia, Jerzy Windyga, Roseline d'Oiron, Paul Moorehead, Sunita Koparkar, Vanda Teodoro, Amy D Shapiro, Johannes Oldenburg, Cedric Hermans
Journal: The Lancet Haematology (2023)
PPD04.01 Survival Associations of T cell Clusters with Immunotherapy in Mesothelioma
Authors: A. Desai, F. Kosari, M. Disselhorst, A. Agahi, J. Yin, T. Peikert, J. Udell, S. Johnson, J. Smadbeck, S. Murphy, A. McCune, G. Karagouga, J.S. Klein, M. Borad, J. Cheville, G. Vasmatzis, P. Baas, A. Mansfield
Journal: Journal of Thoracic Oncology (2023)
PP01.59 Performance of a Deep Learning Algorithm for the Early Detection of Malignant Lung Nodules
Authors: M. Tadepalli, A. Chhaparwal, S. Chawla, S. Srivastava, T. Dao, A. Codlin, S. Naren, S. Sathyamurthy, S.V. Mukkavilli, P. Putha, B. Reddy, L. Vo, P. Warrier
Journal: Journal of Thoracic Oncology (2023)
PP01.54 ImmunoBlood: A Prospective Study Evaluating the Development of Anti-Checkpoint Inhibitor Antibodies in Patients with Advanced Non-Small Cell Lung Cancer Treated with Immunotherapy
Authors: C. Orciuolo, R. Sorrentino, C. Colarusso, S. Ceddia, G. Minuti, L. Conti, C. Mandoj, S. Carpano, L. Canali, C. Fucci, M. Brandi, F. Fusco, M. Giammaruco, B. Resuli, L. Landi, F. Cappuzzo
Journal: Journal of Thoracic Oncology (2023)
PP01.76 Lurbinectedin vs an External Control arm in Patients with Small Cell Lung Cancer
Authors: A. Kishor Ganti, P. Prince, X. Wang, A. Estrin, A. Boccuti, B. Rengarajan, N. Naveh, R. D'Agostino, T. Alvord, R. Ben-Joseph
Journal: Journal of Thoracic Oncology (2023)
PP01.01 PEOPLE (NTC03447678), a Phase II Trial to Test Biomarkers of Response to Pembrolizumab as First-Line Treatment in Advanced NSCLC Patients with PD-L1&gt;50%
Authors: J. Dolezal, G. Lo Russo, C. Proto, A. Prelaj, M. Ganzinelli, R. Mortarini, V. Torri, R. Ferarra, L. Agnelli, S. Brich, M.C. Garassino
Journal: Journal of Thoracic Oncology (2023)
PP01.11 Furmonertinib is an Oral, Irreversible, Highly Brain-Penetrant Pan-EGFR Inhibitor with Activity Against Classical and Atypical EGFR Mutations
Authors: L. Musib, M. Kowanetz, Q. Li, H. Luo, J. Hu, S. Lutzker
Journal: Journal of Thoracic Oncology (2023)
PPD02.03 Tepotinib in Patients with MET Exon 14 (METex14) Skipping NSCLC: Analysis of All Patients From VISION Cohorts A and C
Authors: M.C. Garassino, M. Thomas, E. Felip, H. Sakai, X. Le, R. Veillon, E.F. Smit, J. Mazieres, A.B. Cortot, J. Raskin, S. Viteri, J. Chih-Hsin Yang, M.-J. Ahn, Y.-L. Wu, R. Ma, J. Zhao, A. O'Brate, K. Berghoff, R. Bruns, G. Otto, P. Paik
Journal: Journal of Thoracic Oncology (2023)
PP01.28 Tumor Engraftment is Prognostic for Disease Recurrence in Resected Non-Small Cell Lung Cancer
Authors: B.G. Patel, K. Pepin, S. Li, S.R. Davies, A. Rohatgi, B. Herzog, J.P. Ward, M. Baggstrom, S. Waqar, D. Morgensztern, R. Govindan, S. Devarakonda
Journal: Journal of Thoracic Oncology (2023)
PP01.53 Pathologic Response Assessment Tool – Architecting a Cloud-Based Tool to Streamline Logistics for Shipping, Tracking, Scoring, and Reporting
Authors: J. Posadas Ruiz, A. Walker, H. Zhu, N. Bota-Rabassedas, S. Wijeratne, C. Connolly, M. Wynes, B. Sanchez-Espiridion, S. Dacic, I. Wistuba, J. Lee
Journal: Journal of Thoracic Oncology (2023)
PP01.18 Surgical Resection after Targeted Therapy in Stage IV NSCLC: Nuances and Considerations
Authors: M. Antonoff, N. Deboever, S. Swisher, B. Sepesi, M. Altan, A. Vaporciyan, J. Heymach, S. Gandhi, Y. Elamin
Journal: Journal of Thoracic Oncology (2023)
PP01.29 Prevalence and Predictor of Significant Unmet Needs in Patients who were Surgically Resected for Non-Small Cell Lung Cancer
Authors: J. Park, W. Jung, G. Lee, D. Kang, Y. Mog Shim, H.K. Kim, J. Cho, D.W. Shin
Journal: Journal of Thoracic Oncology (2023)
OA01.04 First-Line Nivolumab + Ipilimumab + Chemotherapy in Metastatic NSCLC: CheckMate 9LA 3-Year Update
Authors: D.P. Carbone, L.G. Paz-Ares, T.E. Ciuleanu, M. Cobo-Dols, J. Bennouna, Y. Cheng, H. Mizutani, A. Lingua, F. Reyes, N. Reinmuth, J. Menezes, J. Jassem, S. Protsenko, K. Feeney, E. de la Mora Jimenez, S. Lu, T. John, X. Zhang, N. Hu, M. Reck
Journal: Journal of Thoracic Oncology (2023)
PP01.34 Induction of Tertiary Lymphoid Structures in Non-Small Cell Lung Cancer Improves B and T Cell Anti-Tumor Immunity
Authors: H. Mi Kim, D. Liu, A. Ruffin, A. McDonough, C. Lampenfeld, S. Kunning, A. Somasundaram, L. Stabile, T. Bruno
Journal: Journal of Thoracic Oncology (2023)
PP01.04 Hispanic Patients are at Higher Risk for Delayed Time to Surgery Following Identification of a Solid Lung Nodule
Authors: D. Phan, R. Riccardi, G. Dawodu, J. Rodriguez Quintero, B. Ferrell, S. Sarosh Sohail, P. Friedmann, N. Chudgar, B. Stiles
Journal: Journal of Thoracic Oncology (2023)
PP01.25 Incidence and Timing of Immune-Related Adverse Events in Patients With Non-Small Cell Lung Cancer Treated With Immune Checkpoint Inhibitor as Monotherapy or in Combination With Chemotherapy
Authors: A. Secor, S. Zhao, L. Wei, P. Das, T. Haddad, A. Miah, D. Spakowicz, G. Lopez, M. Husain, M. Grogan, M. Li, C. Schweitzer, C. Pilcher, D. Uribe, G. Cheng, M. Phelps, J. Guo, P. Shields, K. He, E. Bertino, D. Carbone, G. Otterson, C.J. Presley, D.H. Owen
Journal: Journal of Thoracic Oncology (2023)
OA01.01 Second Primary Lung Cancer among Lung Cancer Survivors Who Never Smoked
Authors: E. Choi, C. Su, J. Wu, J. Aredo, J. Neal, A. Leung, L. Backhus, L. Marchand, S.Y. Liang, I. Cheng, H. Wakelee, S. Han
Journal: Journal of Thoracic Oncology (2023)
PP01.49 Analysis of Outcomes by Race in Patients with Advanced NSCLC
Authors: D. Dressler, J.R. Fuchs, P. Silberman, M. Kocherginsky, Z. Sun, Y. Boumber, Y. Kwang Chae, N. Mohindra, A. Ragam, C.V. Vakkalagadda, J. Patel
Journal: Journal of Thoracic Oncology (2023)
PP01.56 Peripheral T-Cell Receptor Repertoire Dynamics in Patients with Small Cell Lung Cancer
Authors: M.L. Balbach, M.L. Axelrod, J. Balko, A. Bankhead, T. Shaffer, L. Lim, J. Guo, M. Li, W.T. Iams
Journal: Journal of Thoracic Oncology (2023)
PP01.48 Efficacy and Safety of Patritumab Deruxtecan (HER3-DXd) in Locally Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC) without EGFR-Activating Mutations
Authors: M.L. Johnson, C.E. Steuer, H. Hayashi, W.-C. Su, M. Nishio, D.-W. Kim, M. Koczywas, E. Felip, K.A. Gold, H. Murakami, C.S. Baik, S.-W. Kim, E.F. Smit, M. Gigantone, B. Kim, P.-D. Fan, Z. Qi, E.Y. Wu, D. Sternberg, P.A. Jänne
Journal: Journal of Thoracic Oncology (2023)
PP01.12 Increasing Diagnosis of Ground Glass Nodules and Semi-Solid Lung Lesions on Chest CT Scans over the Past Decade
Authors: G. Woodard, L. Tanoue, F. Detterbeck, D. Boffa, V. Mase, J. Blasberg, A. Dhanasopon, B. Gosangi, L. Traube, A. Bader
Journal: Journal of Thoracic Oncology (2023)
PP01.55 Real-World Treatment Sequencing and Impact on Outcomes in ALK-Positive (ALK+) Non–Small Cell Lung Cancer (NSCLC)
Authors: Y. Wan, J. Elliott, M. Young, Y. Yin, K. Arnaoutakis, K. Leventakos, H.M. Lin, A. Dimou
Journal: Journal of Thoracic Oncology (2023)
PP01.10 A Randomized, Open-Label Phase 2 Study of the TORC 1/2 Inhibitor Sapanisertib in Relapsed/Refractory (R/R) NFE2L2 (NRF2)-Mutated and Wild-Type (WT) Squamous Non-Small Cell Lung Cancer (sqNSCLC)
Authors: J.W. Riess, M.L. Johnson, S. Gadgeel, F. Skoulidis, B. Sumrow, E. Kuriakose, K. Albert, N. Kittrell, L. Akella, G. Fiji, P. Paik
Journal: Journal of Thoracic Oncology (2023)
PP01.17 Sotorasib in Advanced KRAS p.G12C–Mutated NSCLC with Treated or Untreated Brain Metastases: Safety and Efficacy Data from the Global Expanded Access Program (EAP)
Authors: M.M. Awad, G. Pelizzari, J. Stevenson, M. Majem, C. Gil Ferreira, W. Petty, E. Arriola, J. De Castro, I. Morbeck, J. Bauman, L. Toschi, A. Zer, G. Metro, S. Kalmadi, A. Azkárate, C. Xia, A. Meloni, C. Obiozor, H. Hsu, T. Varrieur, C. Ardito-Abraham, N. Maimon, S. Novello
Journal: Journal of Thoracic Oncology (2023)
PP01.64 A Safety and Efficacy Analysis Comparing Elderly vs Nonelderly Patients Treated with Consolidation Immunotherapy after Chemoradiation for stage III NSCLC from the BTCRC LUN 16-081 Clinical Trial
Authors: S. Shahani, G. Durm, S. Althouse, Z. Liu, N. Hanna
Journal: Journal of Thoracic Oncology (2023)
PP01.15 Circulating Tumor DNA (ctDNA) Level: a Prognostic Biomarker for Clinical Outcomes in Non-Small Cell Lung Cancer (NSCLC) Patients Across Diverse Therapy Classes
Authors: L. Mowlavi, J. Liao, C. Weipert, E. Rodriguez, C. Rolfo, H.-Y. Chuang, S. Gordon
Journal: Journal of Thoracic Oncology (2023)
PP01.38 Biomarker Testing and Associated Treatment patterns in Advanced Non-Small Cell Lung Cancer in the US
Authors: M. Last, H. Burlison, S. Chandrasekar, C. Hooi Wong, H. Bailey, C. Forshaw, G. Foley, K. Duncan, S. Krulewicz, R. Wiltshire, D. Thomaidou, L. Iadeluca
Journal: Journal of Thoracic Oncology (2023)
PP01.63 Real-World Assessment of Clinical Outcomes Associated with Immunotherapy (IO) and chemotherapy in Non–Small Cell Lung Cancer (NSCLC) Patients with Brain Metastases and METexon14 Skipping Mutations Treated in US Community Centers
Authors: B. Cai, S.A. Arnold Egloff, R.K. Goyal, B. Cai, N. Caro, M. Frost, S. Mahmud, V.D. Ansquer, K.L. Davis, L. Brisbin, M. Lisi, A.J. McKenzie, S. Paulson
Journal: Journal of Thoracic Oncology (2023)
PPD02.01 Comprehensive Genomic Profiling (CGP) for Diagnostic Clarity in Pulmonary Large-Cell Neuroendocrine Carcinoma (LCNEC)
Authors: U. Tapan, K. Raskina, R. Huang, A. Schrock, J. Sands, G. Oxnard, H. Tukachinsky
Journal: Journal of Thoracic Oncology (2023)
PP01.57 Evaluation of the Metabolism of the Biogenic Amines on the Neuroendocrine Differentiation of A549 Adenocarcinoma Cells
Authors: I. Mendieta, G. Pérez-Sánchez, L. Pavón-Romero, G. García-Alcocer, L. Cristina Berumen
Journal: Journal of Thoracic Oncology (2023)
PP01.50 EMERGE-201: Phase 2 Basket Study of Lurbinectedin Monotherapy in Advanced or Metastatic Solid Tumors
Authors: D. Spigel, M.D. Galsky, A.L. Heeke, L.C. Villaruz, J. Sands, V. Subbiah, G. Sonpavde, A.P. Singh, S. Srinivas, G. Brock, G. Cai, K. Bhatt, D. Chakrabarti
Journal: Journal of Thoracic Oncology (2023)
PP01.31 Real-World Treatment Outcomes of Amivantamab in Pre-Approval Access (PAA) Participants with Advanced Non-Small Cell Lung Cancer (NSCLC) with EGFR Exon 20 Insertion Mutations (ex20ins)
Authors: J. Sabari, T.M. Kim, A. Spira, S.H. Lee, G.C. Chang, J.-Y. Shih, M.J. Hochmair, C.A. Schioppa, C.A. Schioppa, A. Panaccione, J.B. Rose, M. Chioda, P. Mahadevia, B.C. Cho
Journal: Journal of Thoracic Oncology (2023)
PPD04.02 First-Line Nivolumab + Ipilimumab (NIVO+IPI) in Metastatic NSCLC: 5-Year Survival in CheckMate 227
Authors: H. Borghaei, J.R. Brahmer, J.-S. Lee, T.-E. Ciuleanu, R. Bernabe Caro, M. Nishio, L. Urban, C. Audigier-Valette, L. Lupinacci, R. Sangha, L.G. Paz-Ares, M. Reck, K. John O’Byrne, R.G. Gupta, J. Bushong, L. Li, S.I. Blum, L. Eccles, S.S. Ramalingam
Journal: Journal of Thoracic Oncology (2023)
PP01.21 Utilization of Pre- and Post-Stereotactic Body Radiotherapy (SBRT) Neutrophil-to-Lymphocyte (NLR) Ratios and Platelet-to-Lymphocyte (PLR) Ratios as Prognostic Factors in Early-Stage Non-Small Cell Lung Cancer
Authors: N. Sharma, T. Podder, T. Biswas
Journal: Journal of Thoracic Oncology (2023)
PP01.13 Low Screening Rates in Patients Ultimately Diagnosed with Advanced NSCLC
Authors: D. Dressler, J. Fuchs, P. Silberman, M. Kocherginsky, Z. Sun, Y. Boumber, Y. Kwang Chae, N. Mohindra, A. Ragam, C. Vakkalagadda, J. Patel
Journal: Journal of Thoracic Oncology (2023)
PP01.05 Impact of PD-L1 Status on Survival on Immunotherapy Monotherapy in Real-World Patients with Poor Performance Status: A US Nationwide Veterans Affairs Study
Authors: J. Wu, C. Su, J. La, J. Corrigan, M. Das, N. Do, M. Brophy, S. Ahmed, S. Han, N. Fillmore, M. Kelley
Journal: Journal of Thoracic Oncology (2023)
PP01.61 First-Line Treatment Patterns of Patients with Metastatic Non-Small Cell Lung Cancer (mNSCLC) with and without BRAF Mutations in the US
Authors: M. Cecilia Vieira, K. Duncan, W.-C. Hsu, R. Ross, D. Benjumea, A. Vlahiotis, B. Li, K.D. Wilner
Journal: Journal of Thoracic Oncology (2023)
PP01.70 Prevalence, Treatment Patterns, and Survival by Age in Patients Diagnosed with Metastatic Non-Small Cell Lung Cancer (mNSCLC) and Brain Metastases (BM) in the United States
Authors: M. Danese, B. Korytowsky, M. Laurie, A. Scofield, J. Shafrin
Journal: Journal of Thoracic Oncology (2023)
PP01.06 Circulomic Variables may Predict Pathologic Staging Preoperatively in Treatment-Naïve Non-Small Cell Lung Cancer
Authors: N. Deboever, M. Eisenberg, W. Hofstetter, R. Mehran, R. Rajaram, D. Rice, J. Roth, B. Sepesi, S. Swisher, A. Vaporciyan, G. Walsh, M. Antonoff
Journal: Journal of Thoracic Oncology (2023)
PPD02.02 Tepotinib + Gefitinib in Patients with EGFR-Mutant NSCLC with MET Amplification (METamp): Final Analysis of INSIGHT
Authors: R. OHara, C. Kin Liam, A. Rozila Ahmad, T.-C. Hsia, J. Zhou, D.-W. Kim, R. Andrew Soo, Y. Cheng, S. Lu, S. Won Shin, J. Chih-Hsin Yang, Y. Zhang, J. Zhao, R. Bruns, A. Johne, Y.-L. Wu
Journal: Journal of Thoracic Oncology (2023)
PP01.58 Multi City Opportunistic Screening of Lung Nodules amidst COVID-19
Authors: S. Mandal, S. Sathyamurthy, A. Govindarajan, E. Dwivedi, V. Challa, P. Vanapalli, R. Prakash, A. Modi, R. Chouhan, P. Putha, A. Kothari, B. Reddy
Journal: Journal of Thoracic Oncology (2023)
PP01.23 Outcomes of Stage IIIA Disease in NSCLC, Treated with Surgery - A Single Institution Experience
Authors: P.G. Gamit, J. Saikia, P.S. Malik, S. Kumar, D. Jain, K. Madan, S.J. Bharati, S. Deo, S. Kumar
Journal: Journal of Thoracic Oncology (2023)
PP01.47 HERTHENA-Lung02: A Randomized Phase 3 Study of Patritumab Deruxtecan vs Platinum-Based Chemotherapy in Locally Advanced or Metastatic EGFR-Mutated NSCLC After Progression with a Third-Generation EGFR TKI
Authors: B. Halmos, H. Yu, Y.-L. Wu, M. Nishio, M. Reck, E. Wu, D. Sternberg, S. Esker, T. Mok
Journal: Journal of Thoracic Oncology (2023)
PP01.74 Clinical Validation of a Promising New Amplicon-Based Liquid Biopsy Platform for Detection of Guideline Recommended Biomarkers in Metastatic NSCLC
Authors: R. Dawar, J. Carney, R.M. Jotte, J. Orsini, K. Scilla, G. Lopes, M.-H. Tan, B.C. Goh, Y.O. Tan, T.M. Chin, C.K. Toh, J. Samol
Journal: Journal of Thoracic Oncology (2023)
PP01.44 Long-Term Survival and Outcomes by Race from the Phase I/II trial of Carboplatin, Nab-paclitaxel, and Pembrolizumab for Advanced NSCLC: HCRN LUN13-175
Authors: R. Gentzler, N. Mohindra, S. Jalal, K. Reckamp, R. Hall, N. Hanna, Y. Chae, M. Koczywas, I. Helenowski, J. Patel
Journal: Journal of Thoracic Oncology (2023)
PP01.37 Quality of Life in Non-Small Cell Lung Cancer Patients With Brain/CNS Metastases– Real-world evidence
Authors: H. Bailey, C. Forshaw, S. Chandrasekar, C. Hooi Wong, M. Last, H. Burlison, G. Foley, L. Iadeluca, S. Krulewicz, R. Wiltshire, D. Thomaidou, K. Duncan
Journal: Journal of Thoracic Oncology (2023)
PP01.39 Infrastructure for Interobserver Variability Assessment of Pathologic Response (PR), in Surgical Resection Specimens Following Neoadjuvant Immune Check Point Inhibitor (ICI) Therapies in Early Stage NSCLC
Authors: N. Bota-Rabassedas, S. Wijeratne, C. Connolly, M. Wynes, B. Sanchez-Espiridion, J. Fujimoto, J. Posadas, A. Walker, H. Zhu, S. Dacic, W. Travis, J. Lee, K. Kerr, C. Glass, A. Saqui, L. Sholl, W. Cooper, A. Roden, C. Poleri, J.-H. Chung, J. Lopez-Martin, A. Borczuk, A. Weissferdt, I. Wistuba
Journal: Journal of Thoracic Oncology (2023)
PP01.65 Treatment Patterns of Malignant Pleural Mesothelioma in a Resource Limited Setting: A “Real World” Study
Authors: K. Morales Hernández, S. Zarroca Palacio, M. Antonio Hernández Castillo, D.Y. Remolina Bonilla, J. Jose Sánchez Hernández, A. Vélez Martínez, G. Chaires Navarro, M. Najar Rodríguez, A. Irigoyen Alvarez, N. Lizcano Aguilar, E. Sánchez Roman, B. Lorena Rubio Anguiano, D. Angelica De Jesús Hernández, C. Peña Campos, R. Rogelio Trejo Rosales
Journal: Journal of Thoracic Oncology (2023)
Clinical Outcomes after Ocular Trauma with Orbeez Gel Pellet Projectiles
Authors: Benjamin R. Lin, Hasenin Al-Khersan, Tyler Rowsey, Matthew West, Albert Lin, Phillip Qu, Elena Bitrian, Julia Hudson, Michael Venincasa, Jason Fan, Naomi Gutkind, J. Daniel Diaz, Prashant Parekh, Harris Sultan, Nicolas A. Yannuzzi
Journal: Ophthalmology (2023)
Advances in Nanozymes as a Paradigm for Viral Diagnostics and Therapy
Authors: Garima Sharma, Srijan Chatterjee, Chiranjib Chakraborty, Jin-Chul Kim
Journal: Pharmacological Reviews (2023)

Over the last few decades, humankind has constantly encountered new viral species that create havoc in the socio-economic balance worldwide. Among the method to combat these novel viral infections, fast and Point-of-care diagnosis is of prime importance to contain the spreading of viral infections. However, most sensitive diagnostic systems for viral infections are time-consuming and require well-trained professionals, making it difficult for the patients. In recent years nanozymes emerged as promising therapeutic and fast diagnostic tools due to their multienzyme-like catalytic performance. Nanozymes can be designed using inorganic or organic components with tailorable physicochemical surface properties, enabling the attachment of various molecules and species on the surface of the nanozyme for specific recognition. In addition to the composition, the multienzyme-like catalytic performance can be modulated by the shape and size of the nanoparticles. Due to their multicatalytic abilities, nanozymes can be used for fast diagnosis and therapy for viral infections. Here we attempt to focus on the insights and recent explorations on the advances in designing various types of nanozymes as a theranostic tool for viral infections. Thus, this review intends to generate interest in the clinical translation of nanozymes as a theranostic tool for viral infections by providing knowledge about the multidisciplinary potential of nanozyme. <b>Significance Statement</b> The multienzyme-like properties of nanozymes suggest their role in diagnosing and treating various diseases. Although the potential roles of nanozymes for various viral infections have been studied in the last few decades, no review provides recent explorations on designing various types of nanozymes for the detection and treatment of viral infections. This review will provide insights into designing nanozymes to diagnose and treat viral infections, assisting future researchers in developing clinically translatable nanozymes to combat novel viral infections.
T-independent responses to polysaccharides in humans mobilize marginal zone B cells prediversified against gut bacterial antigens
Authors: Sandra Weller, Delphine Sterlin, Tatiana Fadeev, Eva Coignard, Alba Verge de los Aires, Clara Goetz, Rémi Fritzen, Mathilde Bahuaud, Frederic Batteux, Guy Gorochov, Jean-Claude Weill, Claude-Agnès Reynaud
Journal: Science Immunology (2023)

Marginal zone (MZ) B cells are one of the main actors of T-independent (TI) responses in mice. To identify the B cell subset(s) involved in such responses in humans, we vaccinated healthy individuals with Pneumovax, a model TI vaccine. By high-throughput repertoire sequencing of plasma cells (PCs) isolated 7 days after vaccination and of different B cell subpopulations before and after vaccination, we show that the PC response mobilizes large clones systematically, including an immunoglobulin M component, whose diversification and amplification predated the pneumococcal vaccination. These clones could be mainly traced back to MZ B cells, together with clonally related IgA+ and, to a lesser extent, IgG+CD27+ B cells. Recombinant monoclonal antibodies isolated from large PC clones recognized a wide array of bacterial species from the gut flora, indicating that TI responses in humans largely mobilize MZ and switched B cells that most likely prediversified during mucosal immune responses against bacterial antigens and acquired pneumococcal cross-reactivity through somatic hypermutation.