tbuckley/cabot-search huggingface dataset:
The Nature and Treatment of Mental Disorders
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Characterization of the antiviral effects of 2′ carbodeoxyguanosine in ducks chronically infected with duck hepatitis B virus
Authors: William S. Mason, John Cullen, Jeff Saputelli, Tsung-Teh Wu, Chen Liu, Thomas W. London, Edward Lustbader, Priscilla Schaffer, Anna P. O’Connell, Isabelle Fourel, Carol E. Aldrich, Allison R. Jilbert
Journal: Hepatology (1994)

This study was carried out to evaluate benefits and limitations of long-term therapy of hepatitis B virus infections with a nucleoside analog inhibitor of virus replication. The model we used was the domestic duck chronically infected with duck hepatitis B virus by in ovo infection. 2′ Carbodeoxyguanosine was used as an inhibitor of viral DNA synthesis. In all animals examined there was a reduction in virus production during therapy. A dose of 2′ carbodeoxyguanosine of 10 μg/kg every other day reduced the number of infected hepatocytes from greater than 95 to 25 to 50 in less than 3 mo, whereas a 10-fold higher dose produced a decline to less than 10. Histological evaluation revealed mild to moderate liver injury in ducks receiving the higher dose of 2′ carbodeoxyguanosine, suggesting that disappearance of infected hepatocytes may have been accelerated by a toxic effect of the drug. Drug treatment did not completely eliminate duck hepatitis B virus from any duck, and replication was restored in all hepatocytes within a few weeks to several months after antiviral therapy was terminated. Our results suggest that elimination of a chronic infection with a single inhibitor of replication may be difficult in a host that lacks an antiviral immune response capable of eliminating at least a portion of the infected hepatocytes and of ultimately producing antibodies capable of neutralizing residual virus. (Hepatology 1994; 19:398-411).
Retinoid-Specific Induction of Differentiation and Reduction of the DNA Synthesis Rate and Tumor-Forming Ability of a Stem Cell Line From a Rat Mammary Tumor&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Rudland, Philip S., Paterson, Frieda C., Davies, Anna C. Twiston, Warburton, Michael J.
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Retinoid-Specific Induction of Differentiation and Reduction of the DNA Synthesis Rate and Tumor-Forming Ability of a Stem Cell Line From a Rat Mammary Tumor Get access Philip S. Rudland, Philip S. Rudland Search for other works by this author on: Oxford Academic PubMed Google Scholar Frieda C. Paterson, Frieda C. Paterson Search for other works by this author on: Oxford Academic PubMed Google Scholar Anna C. Twiston Davies, Anna C. Twiston Davies Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael J. Warburton Michael J. Warburton Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 70, Issue 5, May 1983, Pages 949–958, https://doi.org/10.1093/jnci/70.5.949 Published: 01 May 1983 Article history Received: 19 August 1982 Accepted: 13 December 1982 Published: 01 May 1983
Industrial Pressure and The Population Problem— The FDA and the Pill
Authors: Irwin C. Winter
Journal: JAMA (1970)

<h3>To the Editor.—</h3> The Friday, Jan 16, 1970, issue of the<i>Washington Post</i>, page A7, quotes one of the eminent scientists who testified at the January hearings of the Nelson Committee as saying "that `industrial pressure' and the `urgency of the population problem' led in 1960 `to a most prompt and indulgent endorsement of the pill' by the Food and Drug Administration and birth control advocates." The story also quotes the same expert as stating that "intensely venal pressures... to neutralize the best efforts of any of us,... who proposed... a more orderly procedure for testing and licensing the pill." The more recent testimony of Dr. Edwards and Dr. Jennings before the same hearings did little to clarify the actual process which occurred in 1960. This is hardly surprising, since neither was on board at the time. Since in 1959 there was only one manufacturer, and we were it, and
Physical and Emotional Function of Primary Care Patients: Scientific Requirements for the Measurement of Functional Health Status
Authors: Larry W. Chambers
Journal: JAMA (1983)

The recent World Health Organization report,<i>Development of Indicators for Monitoring Progress Towards Health for All by the Year 2000</i>,<sup>1</sup>focused attention on alternative indicators for measuring health problems. In the primary care setting, defining health in terms of diagnoses is problematic because often only symptoms and the functional status of the patient's problem are known, not the underlying pathophysiology.<sup>2,3</sup>As more primary care health professionals attempt to evaluate scientifically the impact of their care on patients, they are faced with a new question—how should functional health status be measured in the primary care setting? In this issue ofThe Journal(p 3331), Nelson et al address the following questions: What is the level of physical and mental function of adult patients making office visits to primary care practices? How much agreement is there on function ratings between the clinician and the patient? What are the sources of
Tests of Blood Coagulation and Hemostasis
Authors: Paul Didisheim
Journal: JAMA (1966)

Probably the most widely used of all clotting tests, Quick's prothrombin time (PT)<sup>1</sup>is perhaps the least well understood. Despite its name, we now know that the PT is relatively insensitive to prothrombin (factor II). The test measures the rate of conversion of prothrombin to thrombin in the presence of a tissue extract (thromboplastin) and calcium ions, followed by the polymerization of fibrinogen by thrombin to fibrin. The PT is influenced by the concentrations of four clotting factors besides prothrombin: I (fibrinogen), V (labile factor), VII (stable factor), and X (Stuart-Prower factor). In addition, heparin prolongs the PT, a point frequently overlooked in managing patients treated with anticoagulants. However, the sensitivity of the PT to many factors is the very reason that it is so useful clinically. In patients receiving anticoagulants orally, deficiencies develop in four clotting factors: prothrombin, VII, IX (plasma thromboplastin component), and X. Factor VII decreases
Dislocation of the Elbow With Brachial Artery Injury
Authors: Otto E. Aufranc
Journal: JAMA (1966)

Dr. Turner: A 50-year-old printer caught his ring in a printing machine, and his entire left arm was drawn into the machine. The arm was crushed at the elbow under a heavy metal printing stamp. The limb was withdrawn, and he was taken to a community hospital where the diagnoses of elbow dislocation and brachial artery laceration were confirmed. With the patient under general anesthesia, the elbow was reduced and the wound was debrided. The lacerated brachial artery was repaired by primary anastomosis. There was persistent postoperative bleeding from the wound itself, but distal circulation was not restored. The patient was referred to the Massachusetts General Hospital for further evaluation, and arrived here approximately seven hours following his injury. Results of examination on arrival were normal except for the left arm, which was cold, pulseless, cyanotic, and hypesthetic below the elbow. There was complete absence of pulsatile arterial flow in
Cocaine-condom Ingestion
Authors: Carlos A. Suarez
Journal: JAMA (1977)

We report one survivor and two deaths from cocaine toxicity. Cocaine, packaged in condoms, was deliberately ingested to avoid detection by customs agents. Because cocaine is a toxic drug, we recommend surgical removal of the ingested packages, as alternative methods of removal are unreliable and potentially dangerous. (<i>JAMA</i>238:1391-1392, 1977)
Importance of Lyt 1&lt;sup&gt;+&lt;/sup&gt; T-Cells in the Antitumor Activity of an Immunomodulator, SSM,&lt;xref ref-type="fn" rid="FN1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt; Extracted From Human-Type &lt;italic&gt;Tubercle bacilli&lt;/italic&gt;
Authors: Fujio Suzuki, M.D.
 4, Randy R. Brutkiewicz, B.S., Richard B. Pollard, M.D.
Journal: JNCI Journal of the National Cancer Institute (1986)

An arabinomannan lipid extracted from Mycobacterium tuberculosis strain Aoyama B (SSM) is an immunopotentiating agent with interferon-inducing and antitumor activities. In the present study, the possible role(s) of various immunocompetent cells on the antitumor effect of SSM was investigated in mice bearing syngeneic (RL♂1 leukemia) and allogeneic (Ehrlich carcinoma) ascites tumors. When Thy 1+ T-cells were depleted from tumorbearing mice by the administration of monoclonal anti-Thy 1.2 antibody, the protective effect of SSM was eliminated. However, when macrophage (Mø and natural killer (NK) cell activities were depleted by treatment with Mø blockers (trypan blue and carrageenan) or a blocker for NK cells (anti-asialo GM1 antiserum), no alteration of the antitumor' activity of SSM was observed. Therefore, T-Iymphocytes, but not Mø or NK cells, were required for the expression of the antitumor efficacy of SSM. The antitumor activity of SSM was also abrogated by Lyt 1+ T-cells being depleted by treatment with monoclonal anti-Lyt 1.2 antibody, whereas the administration of monoclonal anti-Lyt 2.2 antibody had no effect on the antitumor activity. Independent of Meø, NK cells, or Lyt 2+ T-cells, Lyt 1+ T-lymphocytes appear to play an important role in the expression of the antitumor effects of SSM.
A Text-Book of Operative Surgery, Covering the Surgical Anatomy and Operative Technic Involved in the Operations of General Surgery. Written for Students and Practitioners.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute Renal Failure in a Patient With Polycystic Kidney Disease
Authors: Michael G. Licina
Journal: JAMA (1981)

THE USUAL course of adult polycystic kidney disease is variable, although most patients experience slowly progressive renal failure.<sup>1-4</sup>Rapid deterioration in renal function, however, is rarely seen unless some acute process supervenes.<sup>1,2</sup>We saw a patient with polycystic kidney disease in whom microscopic hematuria and acute renal failure developed. The cause of the renal failure did not become apparent until RBC casts were noted from a urine sediment examination. This finding led to renal biopsy and a diagnosis of idiopathic crescentic rapid progressive glomerulonephritis (RPGN). <h3>Report of a Case</h3> A 69-year-old woman was admitted on April 19, 1980, for progressive, acute renal failure. Adult polycystic kidney disease had been diagnosed by intravenous pyelogram in 1977 and by B-mode sonography in 1979 and 1980. Cysts were also found in the liver in 1979 and 1980. There is no family history of kidney disease, but three older brothers died of
Highlights of This Issue
Journal: Clinical Cancer Research (2014)

The SET oncoprotein, an inhibitor of the protein phosphatase 2A (PP2A) tumor suppressor, is overexpressed in leukemia.To evaluate the efficacy of SET antagonism in chronic myeloid leukemia (CML) and acute myeloid leukemia (AML), Agarwal and colleagues utilized OP449, a specific, cell-penetrating peptide that antagonizes SET's inhibition of PP2A.OP449 inhibited the growth of CML and AML cells harboring a broad range of oncogenic lesions, and this activity was further enhanced when used in combination with small-molecule inhibitors of activated kinases.This synergistic approach combining targeting of SET and phosphatase activation with relevant oncogenic kinase pathway inhibition may offer a novel therapeutic paradigm for treatment-refractory malignancies.
Head and Neck Cancer in Alcoholics
Authors: Benjamin Kissin
Journal: JAMA (1973)

Three thousand seven alcoholics were examined for head and neck abnormalities and interviewed about drinking, smoking, and dietary patterns. Results indicated (1) the alcoholics had significantly more cancer cases than the controls, (2) the head and neck cancer incidence rate for alcoholics was higher than for the general population (286.5 vs 53.9/100,000), and (3) the alcoholics with head and neck cancer were heavy drinkers and smokers for significantly longer periods of time than the alcoholics without head and neck abnormalities.
Cell Proliferation and Drug Resistance in the Response of Colony-Forming Units of Rat Bone Marrow to Repeated Doses of Cytotoxic Agents
Authors: C. D. R. Dunn
Journal: JNCI Journal of the National Cancer Institute (1972)

The previously reported observation that a second dose of busulfan was less effective than the first in depressing colony-forming units (CFU) of rat bone marrow was further studied. After several pretreatments, which altered the cell proliferation characteristics and/or the spleen colony histology, the response of CFU to subsequent treatments with busulfan or the closely related chemical dimethylmyleran (DMM) was investigated. Vinblastine in vivo or the tritiated thymidine suicide technique in vitro provided evidence of changes in two different features, tc and the ratio ts/tc, respectively, of the cell cycle. Changes in the cell proliferation rate influenced the effects of DMM or busulfan on CFU in different ways. In agreement with other published work, the depression of CFU by DMM seemed independent of changes in the cell proliferation rate. The effect of busulfan, however, apparently depended, in a previously unrecognized way, on the cell proliferation characteristics. In several experimental systems, the degree of CFU depression by busulfan was inversely correlated with the level of tritiated thymidine suicide. This effect, which was independent of changes in the differentiation pathways of the CFU and was probably not due to the cellular environment, suggests that cells in DNA synthesis were resistant to the action of busulfan. This conclusion, which necessitates the addition of a class of cytotoxic agents to those previously recognized, can explain several reported differences distinguishing busulfan from the mustard-type alkylating agents.
Cardiac Dimension Changes With Endurance Training
Authors: Fernand Landry
Journal: JAMA (1985)

We studied the sensitivity of cardiac structures to endurance training. To evaluate variability in adaptation, 20 sedentary subjects and ten pairs of monozygotic twins were submitted to a 20-week endurance training program. Maximal oxygen uptake increased significantly in both groups: 11 mL O<sub>2</sub>/kg/min<sup>-1</sup>or 30% in the sedentary group and 6 mL O<sub>2</sub>/kg/min<sup>-1</sup>or 13% in the monozygotic twins. Statistically significant increases in left ventricular diameter, posterior wall and septal thicknesses, as well as left ventricular end-diastolic volume and left ventricular mass were observed in the sedentary subjects, but not in the monozygotic twins. We could demonstrate that after training, twin pairs differed more from each other than at the start. Concomitantly, within-pair resemblance was greater after training than before. Results indicate that cardiac dimensions are amenable to significant modifications under controlled endurance training conditions and furthermore that the extent and variability of the response of cardiac structures to training are perhaps genotype dependent. (<i>JAMA</i>1985;254:77-80)
The Laboratory Mouse: Its Origin, Heredity, and Culture.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Steroid Hormone Receptors in the Rat Mammary Adenocarcinoma Induced by &lt;italic&gt;N&lt;/italic&gt;-Hydroxy-&lt;italic&gt;N&lt;/italic&gt;-2-fluorenylacetamide&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN4"&gt;4&lt;/xref&gt;
Authors: Li, Sara Antonia, Malejka-Giganti, Danuta, Li, Jonathan J.
Journal: JNCI Journal of the National Cancer Institute (1982)

Journal Article Steroid Hormone Receptors in the Rat Mammary Adenocarcinoma Induced by N-Hydroxy-N-2-fluorenylacetamide Get access Sara Antonia Li, Sara Antonia Li 6 5Medical Research Laboratories, Building 49, Veterans Administration Medical Center, 54th St. and 48th Ave., South, Minneapolis, Minn. 55417, and Department of Urologic Surgery, University of Minnesota Medical School, Minneapolis, Minn. 55455. 6Address reprint request to Dr. S. A. Li at the Medical Research Laboratories, Veterans Administration Medical Center. Search for other works by this author on: Oxford Academic PubMed Google Scholar Danuta Malejka-Giganti, Danuta Malejka-Giganti 7Laboratory for Cancer Research, Veterans Administration Medical Center, Minneapolis, Minn. 55417, and Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minn. 55455. Search for other works by this author on: Oxford Academic PubMed Google Scholar Jonathan J. Li Jonathan J. Li 5Medical Research Laboratories, Building 49, Veterans Administration Medical Center, 54th St. and 48th Ave., South, Minneapolis, Minn. 55417, and Department of Urologic Surgery, University of Minnesota Medical School, Minneapolis, Minn. 55455. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 69, Issue 1, July 1982, Pages 41–45, https://doi.org/10.1093/jnci/69.1.41 Published: 01 July 1982 Article history Received: 08 April 1981 Revision received: 14 January 1982 Accepted: 09 February 1982 Published: 01 July 1982
Resource for Managing Sleep Disorders
Authors: Joyce D. Kales
Journal: JAMA (1979)

To enhance physicians' knowledge of the prevalent problem of sleep disorders, a 50-minute videotape program designed as a learning and self-assessment experience in evaluating and treating these disorders was coproduced with the Network for Continuing Medical Education. The program has been presented nationally to about 25,000 medical professionals. The mean correct score was 50% for the pretest, 69% for the instructional section, and 79% for the posttest; the composite score on the posttest was 59% higher than that on the pretest. Physicians' responses indicated strengths and weaknesses in their knowledge of sleep disorders, thus delineating future directions for medical education in insomnia, narcolepsy/cataplexy, nightmares, night terrors, sleepwalking, and enuresis. All of these sleep disorders can be best evaluated and treated by the general physician. (<i>JAMA</i>241:2413-2416, 1979)
Quantitative Measurement and Chromatography of Human Urinary Carcinoembryonic Antigen Activity&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Wu, James T., Madsen, Ace, Bray, Patrick F.
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Quantitative Measurement and Chromatography of Human Urinary Carcinoembryonic Antigen Activity Get access James T. Wu, Ph.D., James T. Wu, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ace Madsen, Ace Madsen Search for other works by this author on: Oxford Academic PubMed Google Scholar Patrick F. Bray, M.D. Patrick F. Bray, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 53, Issue 6, December 1974, Pages 1589–1595, https://doi.org/10.1093/jnci/53.6.1589 Published: 01 December 1974 Article history Received: 20 May 1974 Accepted: 08 August 1974 Published: 01 December 1974
Age Trends in Autopsy Rates
Authors: Judith C. Ahronheim
Journal: JAMA (1983)

Age-related autopsy rates were computed from 99,145 death certificates and disclosed a striking decline with advancing age, the peak (82.5%) occurring in the third decade of life, the nadir (2.4%) by age 90 years. The trend was the same for both sexes, although at all ages men were more likely to undergo autopsies than women. There was a significant decline in late life for medical examiner (ME) and non-ME cases. Rates varied according to immediate cause of death. The only causes of death in which there was no significant age-associated decline were homicide, suicide, and transport accidents, where autopsy is mandated by law. For other causes of death analyzed, rates declined significantly with age in both sexes, for ME as well as for non-ME cases. We conclude that low autopsy rates in late life are not artifactual but represent an overall phenomenon deserving closer scrutiny. (<i>JAMA</i>1983;250:1182-1186)