tbuckley/cabot-search huggingface dataset:
Hepatic artery infusion for recurrent or chemoresistant hepatic malignancy.
Authors: Harold J. Wanebo, Charu Taneja, Riogard Srinivasa, Giovanni Begossi, James Belliveau
Journal: Journal of Clinical Oncology (2014)

e14632 Background: Previously treated Hepatic Colorectal Metastases (CRC) and advanced hepato cellular cancer (HCC) are tumor challenges frequently unresponsive to systemic chemo therapy (CT). We reviewed survival outcome in chemo resistant/high risk patients following hepatic artery infusion (HAI) in 21 CRC pts, 10 HCC pts, and 6 miscellaneous metastatic cancers. Methods: Patient groups: 21 CRC pts, (16M, 5F), mean age 63; 16 had metachronous (DFI-17 mos), and 5 synchronous CA; liver extent: 76% multiple (>5) mets or extensive bilateral, CEA (ng/m), >100, 8 pts >50 (3pts) and, NA - 7 pts. Previous CT: FU/LV (11 pts), Oxaliplatin (OX) or Irinotecan (IR) 10 pts. Liver surgery: Partial Resection/RFA - 9 pts. HCC 9 pts, cholangio CA 1 pt, M/F 5/5, average age 63. Previous RX Hepatic lobectomy4 pts,RFA/TACE 3 pts. Miscellaneous gp; Lobectomy +/- HAI were done in metastatic lung (1), Breast (1), advanced gallbladder (BGCA) (T3-4) (2 pts); HAI alone was done in Br. CA (1) and carcinoid (1). Treatment Protocols: CRC Protocol: HAI-FUDR 12-15mg/kg/d, dexamethasone 2mg/kg/d, Leukovorin 20mg/m2/d (14 d) plus bolus infusion (d1), Oxaliplatin (OX) 130mg/m2 (or Cisplatin (CIS) 100mg m2 d1); Systemic RX: d20-30. OX I>V. 130mg/m2, capecitabine 750-1000mg/m2/d x 10 days (also used in Miscel. Grp. HCC Protocol: HAI-14 d as in CRC Protocol. Bolus infusion d1-doxorubicin 75mg/m2 or OX or CIS as in CRC schema. Results: CRC: OS-CRC post start HAI = med/16 mos, 2yr/5yr = 27%/6%; HCC OS = 9 mos. Median (3-12 mos in 9 evaluable pts; 1 HCC pt, with recurrence 2 yr. post central hepatectomy was treated over 3.5 yrs. with HAI + RFA/TACE - (OS was 67 mo). Miscellaneous group OS included lung (11 mos), Br CA (23, 9 mo) adv. carcinoid (3 mos), GBCA (2 pts.>60 mos) Co:mplications infected pocket (2 pts), duodenal fistual (1 pt). Conclusions: Hepatic artery infusion alternating with systemic chemo chemotherapy has apparent survival benefit in selected patients with persistent or progressive chemo resistant malignancy from metastatic CRC, HCC, or selected miscellaneous cancers (breast, lung, liver, gall bladder cancer) and warrants further study.:
THE OUTLOOK FOR THE MANAGEMENT OF DIABETES
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of Migraine
Authors: John R. Graham
Journal: New England Journal of Medicine (1955)

PreventionPatients may be divided into three main groups so far as the frequency and severity of their attacks of migraine are concerned: those whose attacks are so infrequent that they may be termed an "unpleasant nuisance" but not a "serious threat" to life's normal degree of happiness; those whose attacks are occurring with such frequency or severity, or both, that family, business and social life is seriously disturbed but not completely disrupted; and those whose attacks are so frequent and severe that a state of chronic invalidism is produced and partial or complete disability results.So far as the . . .
Total Hip-Joint Replacement in Sweden
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The prospective multicenter study of relation between 5-HIAA/substance P plasma concentration transition and nausea/vomiting in patients with gastrointestinal cancer receiving moderately emetogenic chemotherapy (MEC)
Authors: K. Sawada, Y. Komatsu, T. Muranaka, S. Nakano, Y. Kawamoto, H. Nakatsumi, S. Yuki, M. Dazai, T. Saiki, A. Ishiguro, M. Tateyama, K. Ono, S. Ohnishi, N. Sakamoto
Journal: Annals of Oncology (2018)
Incidence of Macrocytic Anemia in Rheumatoid Arthritis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Doc, How Much Time Do I Have?
Authors: Charles L. Loprinzi, Mary E. Johnson, Gretchen Steer
Journal: Journal of Clinical Oncology (2000)

Article Tools ART OF ONCOLOGY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2000.18.3.699 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 10653888 Doc, How Much Time Do I Have? Charles L. LoprinzixCharles L. LoprinziSearch for articles by this author , Mary E. JohnsonxMary E. JohnsonSearch for articles by this author , Gretchen SteerxGretchen SteerSearch for articles by this author Show More From the Division of Medical OncologyMayo Clinic, Rochester, MN. https://doi.org/10.1200/JCO.2000.18.3.699 First Page Full Text PDF Figures and Tables © 2000 by American Society of Clinical Oncology
Cost-Effectiveness of Lowering Cholesterol in Older Patients after Heart Attack
Journal: Annals of Internal Medicine (2000)

Summaries for Patients16 May 2000Cost-Effectiveness of Lowering Cholesterol in Older Patients after Heart AttackSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-10-200005160-00037 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Statins are drugs used to lower cholesterol levels. Use of statin therapy to lower cholesterol levels in patients younger than 75 years of age who have had a previous heart attack (secondary prevention) is well accepted in the medical community. However, the use of statins in patients older than 75 years of age has not been well studied. Thus, little is known about the costs and benefits of secondary prevention with statins for patients in this age group.Why did the researchers do this particular study?To find ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “ Cost-Effectiveness of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor Therapy in Older Patients with Myocardial Infarction.” It is in the 16 May 2000 issue of Annals of Internal Medicine (volume 132, pages 780-787). The authors are D.A. Ganz, K.M. Kuntz, G.A. Jacobson, and J. Avorn.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCost-Effectiveness of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor Therapy in Older Patients with Myocardial Infarction David A. Ganz , Karen M. Kuntz , Gretchen A. Jacobson , and Jerry Avorn Metrics 16 May 2000Volume 132, Issue 10Page: 780KeywordsAge groupsCholesterolDrugsLongitudinal studiesMedical risk factorsMyocardial infarctionQuality adjusted life yearsSimulation and modelingStatinsStroke ePublished: 15 August 2000 Issue Published: 16 May 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...
Antibiotic Usage
Authors: Richard Finley
Journal: JAMA (1978)

<h3>To the Editor.—</h3> The recent evaluation by Castle et al (237:2819-2822, 1977) of antibiotic usage at a university hospital is reminiscent of similar reports<sup>1,2</sup>and deserves comment from a perspective not generally seen in print. Castle's group found that 64% of "total antibiotic therapy" was "not indicated" or else was "inappropriately administered." Happily, they avoided the use of popular but gratuitously insulting adjectives such as "irrational," but as an infectious disease specialist who has repeatedly labored to understand and evaluate antimicrobial therapy administered by other physicians, I must say that I find this critical assessment still excessively severe. In the first place, Castle et al do not provide the reader with the explicit criteria one hopes they employed in evaluating antibiotic usage in the 50 patients they reviewed retrospectively. One simply cannot trust one's own knowledge, wisdom, and fairness to suffice in making judgments such as "disagree with the
Leukemia among participants in military maneuvers at a nuclear bomb test. A preliminary report
Authors: G. G. Caldwell
Journal: JAMA (1980)

Preliminary studies indicate that nine cases of leukemia have occurred among 3,224 men who participated in military maneuvers during the 1957 nuclear test explosion "Smoky." This represents a significant increase over the expected incidence of 3.5 cases. They included four cases of acute myelocytic leukemia, three of chronic myelocytic leukemia, and one each of hairy cell and acute lymphocytic leukemia. At time of diagnosis, patient ages ranged from 21 to 60 years (mean, 41.8 years) and the interval from time of nuclear test to diagnosis from two to 19 years (mean, 14.2 years). Film-badge records, which are available for eight of the nine men, indicated gamma radiation exposure levels ranging from 0 to 2,977 mrem (mean, 1,033 mrem). Mean film-badge gamma dose for the entire Smoky cohort was 466.2 mrem. (<i>JAMA</i>244:1575-1578, 1980)
Review of Environmental Factors Affecting Hearing
Authors: John H. Mills, Jacquelyn A. Going
Journal: Environmental Health Perspectives (1982)

The major nongenetic causes of sensorineural hearing loss are exposure to noise, aging, ototoxic drugs, viral and bacterial infections, and interactions between these factors. Regarding exposure to continuous noise, the data base from laboratory and field studies indicates that a risk of hearing loss is present when noise levels exceed 75-80 dBA. As noise level, duration and number of exposures increase so does risk. The data base for other forms of noise (intermittent, impact) is not as established. Risk of hearing loss due to impulse noise increases as the peak SPL exceeds 145-155 dB and as the duration of the impulse, the number of impulses and the number of exposures increase. High-level acoustic impulses can cause severe, permanent hearing loss. Interaction between some steady-state noises and some acoustic impulses can be synergistic, producing extensive injuries to the organ of Corti. Noise can also interact synergistically with some aminoglycoside antibiotics to produce severe injuries in the inner ear. These antibiotics are also capable of producing hearing loss and indeed may do so in up to 55% of the one million persons who receive aminoglycoside antibiotics during the course of treatment for tuberculosis or severe gram-negative infections. Bacterial and viral infections may also produce mild to severe hearing loss. With the development of rubella vaccine and Rhogam, cytomegalovirus may have become the most common cause of congenital deafness. Aging is also a major cause of hearing loss. Exposure to occupational and environmental noise, certain diseases and life styles (diet, stress, drugs) may interact with the specific effects of aging. The result is moderate to severe hearing loss in a majority of older persons.
VA cooperative study finds bypass improves survival in new cohort
Authors: W. Golden
Journal: JAMA (1980)

Veterans Administration physicians say they have discovered that the chances of long-term survival after coronary bypass surgery can be estimated beforehand by data from noninvasive tests. In particular, they say that they have found one new group of high-risk patients who stand to benefit from surgery despite the number of vessels affected by significant atherosclerosis. These findings were presented at the American College of Cardiology meeting in Houston by Timothy Takaro, MD, of the Oteen, NC, VA Hospital, who is surgical cochairman of the Veterans Administration Cooperative Group for the Study of Surgery for Coronary Arterial Occlusive Disease. Cardiovascular specialists present at Takaro's talk, however, advised cautious translation of these findings to clinical decision making. Using the same data base as did those who conducted the controversial prospective randomized VA trial which in 1977 showed no statistical difference in terms of patient outcome between medical and surgical therapy for non-left
EMOTIONS AND PURPURA
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Durable Remission and Survival in Relapsed/Refractory Multiple Myeloma after Allogeneic Hematopoietic Stem Cell Transplantation
Authors: A. Megan Cornelison, Rima M Saliba, Sairah Ahmed, Yago Nieto, Qaiser Bashir, Nina Shah, Simrit Parmar, Krina Patel, Chitra Hosing, Uday R. Popat, Elizabeth J. Shpall, Richard E. Champlin, Muzaffar H. Qazilbash
Journal: Blood (2016)
Effect of cholesterol synthase inhibitor treatment on interleukin-6 and CRP in patients after myocardial infarction Stephan R. Holmer, Christian Hengstenberg, Hannelore Loewel, Susanne Engel, Wolfgang Koenig, Guenter A. J. Riegger, Heribert Schunkert. University of Regensburg Klinik Innere Med. II, Regensburg, Germany, GSF- Institute of Epidemiology, Munich, Germany
Journal: Journal of the American College of Cardiology (2001)
Indirect Health Effects of Relative Humidity in Indoor Environments
Authors: Anthony V. Arundel, Elia M. Sterling, Judith H. Biggin, Theodor D. Sterling
Journal: Environmental Health Perspectives (1986)

A review of the health effects of relative humidity in indoor environments suggests that relative humidity can affect the incidence of respiratory infections and allergies.Experimental studies on airborne-transmitted infectious bacteria and viruses have shown that the survival or infectivity of these organisms is minimized by exposure to relative humidities between 40 and 70%.Nine epidemiological studies examined the relation- ship between the number of respiratory infections or absenteeism and the relative humidity of the office, residence, or school.The incidence of absenteeism or respiratory infections was found to be lower among people working or living in environments with mid-range versus low or high relative humidities.The indoor size of allergenic mite and fungal populations is directly dependent upon the relative humidity.Mite popu- lations are minimized when the relative humidity is below 50% and reach a maximum size at 80% relative humidity.Most species of fungi cannot grow unless the relative humidity exceeds 60%.Relative humidity also affects the rate of offgassing of formaldehyde from indoor building materials, the rate of formation of acids and salts from sulfur and nitrogen dioxide, and the rate of formation of ozone.The influence of relative humidity on the abundance of allergens, pathogens, and noxious chemicals suggests that indoor relative humidity levels should be considered as a factor of indoor air quality.The majority of adverse health effects caused bLy relative humidity would be minimized by maintaining indoor levels between 40 and 60%.This would require humidification during winter in areas with cold winter climates.Humidification should pref- erably use evaporative or steam humidifiers, as cool mist humidifiers can disseminate aerosols contaminated with allergens.
Archives of Ophthalmology, Chicago
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ONE ADVANTAGE OF TEA DRINKING.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal