tbuckley/cabot-search huggingface dataset:
Asclepius—Man or Myth
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outcome Of t(4;14) In Multiple Myeloma - Princess Margaret Cancer Centre Experience Over The Last 10 Years
Authors: Sophia Farooki, Manjula Maganti, Donna E Reece, Esther Masih-Khan, Victor H Jimenez-Zepeda, Suzanne Trudel, Christine I. Chen, Rodger E. Tiedemann, Vishal Kukreti
Journal: Blood (2013)
P11 Afatinib in Patients with EGFR Mutation-Positive (EGFRm+) NSCLC Harboring Uncommon Mutations: Overview of Clinical Data
Authors: O. Arrieta, P. De Marchi, N. Yamamoto, C. Yu, S.I. Ou, C. Zhou, M. Paskevicius, A. Märten, Y. Wu
Journal: Journal of Thoracic Oncology (2018)
Resident Forum
Authors: Mark S. Litwin
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RESUSCITATION BY CARDIAC MASSAGE WITH PARTIAL SUCCESS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A CRITICAL REVIEW OF FIVE HUNDRED CASES OF GASTRIC AND DUODENAL ULCER
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elephant allergy.
Authors: A. J. Spicer, W. O. McCormick
Journal: BMJ (1969)

<h3>Summary</h3> • Copper is an essential nutrient for symbiotic nitrogen fixation. This element is delivered by the host plant to the nodule, where membrane copper transporter would introduce it into the cell to synthesize cupro-proteins. • COPT family members in model legume <i>Medicago truncatula</i> were identified and their expression determined. Yeast complementation assays, confocal microscopy, and phenotypical characterization of a <i>Tnt1</i> insertional mutant line were carried out in the nodule-specific <i>M.truncatula</i> COPT family member. • <i>Medicago truncatula</i> genome encodes eight COPT transporters. <i>MtCOPT1</i> (<i>Medtr4g019870</i>) is the only nodule-specific <i>COPT</i> gene. It is located in the plasma membrane of the differentiation, interzone and early fixation zones. Loss of MtCOPT1 function results in a copper-mitigated reduction of biomass production when the plant obtains its nitrogen exclusively from symbiotic nitrogen fixation. Mutation of <i>MtCOPT1</i> results in diminished nitrogenase activity in nodules, likely an indirect effect from the loss of a copper-dependent function, such as cytochrome oxidase activity in <i>copt1-1</i> bacteroids. • These data are consistent with a model in which MtCOPT1 transports copper from the apoplast into nodule cells to provide copper for essential metabolic processes associated with symbiotic nitrogen fixation.
Parvovirus B19
Authors: Neal S. Young, Kevin E. Brown
Journal: New England Journal of Medicine (2004)

Parvovirus B19 is the cause of fifth disease in children and can trigger transient arthropathy in adults. It can also provoke transient aplastic crises in patients with sickle cell disease or other chronic hemolytic anemias and cause pure red-cell aplasia. This article reviews the features of the virus, the host response to it, and ways of preventing and treating the infection.
Incorrect Data in Table
Authors: Parichita Choudhury, Vijay Ramanan, Bradley Boeve
Journal: JAMA (2021)

In Reply The focus of our recent article 1 was on clinical decision-making surrounding results of APOE allele testing.Although outside the scope of the original article and this response, in our view, the inference of a label of mild cognitive impairment-solely based on a score on an office screening assessment without regard for other data (including but not limited to normal and stable serial clinical evaluations and neuropsychological testing as described in the article)-is also not warranted.The brief vignette describes pertinent history and examination data and otherwise notes the patient as "generally healthy," which we intended to succinctly reflect that the cardinal features of depression were queried, and all were absent except for the cognitive concerns.Although we agree that a psychiatric consultation is reasonable if depression is suspected as a cause or contributor to cognitive concerns, this was not viewed as warranted in this patient.
Error in Text
Authors: Hjalmar De Graaff, Mike Wattjes, Annemieke Rozemuller, Axel Petzold, Joep Killestein, De Graaff
Journal: JAMA Neurology (2013)

Beneficial Prenatal Levodopa Therapy in Autosomal Recessive Guanosine Triphosphate Cyclohydrolase 1 Deficiency
<i>Lehrbuch der Irreheilkunde, für Aerzte und Studirende.</i>Von Dr. Friedrich Scholz, Director der Krankenanstalt und des St. Juergenasyls für Geistes und Nervenkranke zu Bremen. Mit fürnfundzwanzig Tafeln. Eduard Heinrich Mayer, Leipzig, 1892. [Text-book of Insanity, by Dr. Friedrich Scholz.]
Journal: American Journal of Psychiatry (1893)
Expert Witnesses.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disease at the Elephant.
Journal: BMJ (1976)

Disease at the ElephantIn common with so many contemporary institutions, the DHSS seems to have outgrown the concepts of its creators.Oversized, amorphous, and labyrinthine-like Mervyn Peake's Gormenghast-its ramifications have developed an almost neoplastic autonomy: free from any central control or direc- tion, it continues to drain resources in a remorseless but seemingly purposeless growth.More specifically, it has been said: "A sizable proportion of the work of the Department is self-inflicted.This need not be disadvantageous, if what is done is really necessary.But when the simple test [is applied] of asking whether particular activities are really necessary: whether the likely limitation of resources means that much of what is being worked on can ever be translated into reality: or whether there is any effective mechanism within the Department for saying 'no' to what may be desirable in an ideal world, or even interesting, or even beguiling, the answer is clearly that too much happens without any practical justification."That analysis formed the core of an inquiry into the working of the DHSS by a group of chair- men of regional health authorities and was published' by the Department itself (though it is not, it seems, readily available to members of the public).Showing a rare ability to find their way through bureau- cratic fog, the chairmen set out in simple words their initial views on the way the DHSS ought to have been approaching the job of management.The top level should have four main functions: allocation of resources-between capital and revenue and among regions; setting objectives for the Service; ensuring that health authorities were pursuing those objectives and providing a satisfactory quality of health care; and providing the few services which (by statute or for economic reasons) had to be a function of the DHSS itself.They also emphasised that at lower levels management should be organised so that it was absolutely clear which tier was responsible for which decision-and that any question referred upward should be settled with utmost dispatch; and that monitoring "did not mean meddling in the affairs of management teams at lower levels: nor should it involve the duplication of staff and effort which this involves."How far real life at the Elephant differed from this blue- print became clear during the investigation.The complexity of the Department's working was, says the report, "almost totally baffling."In part this was due to two mistaken but well-intentioned beliefs.First was the concept that everyone with even a peripheral interest in a topic had to be given the chance to comment on it-so leading to a proliferation of
Effects of cyclooxygenase inhibition on endothelial function in hypertensive patients treated with angiotensin-converting enzyme inhibitors Hiroshi Yamanari, Tohru Ohe, Kazufumi Nakamura, Mikio Kakishita. Dept. of Cardiovascular Medicine, Okayama University Medical School, Okayama, Japan
Journal: Journal of the American College of Cardiology (2001)
Elements of Surgical Diagnosis.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Erratum</i>: Vol. 65, No. 18
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

In the report, "Mycobacterium abscessus Infections Among Patients of a Pediatric Dentistry Practice -Georgia, 2015," on page 355, the first sentence should have read, "All water samples from the seven dental stations had bacterial counts above the CDC recommended ≤500 colony-forming units (CFU)/mL (average = 91,333 CFU/mL); M. abscessus was isolated from all water samples (3)."
Abstract 18703: Impact of Implantable Cardioverter-defibrillators on Outcome of Patients With Left Ventricular Assist Devices
Authors: Sahil Agrawal, Sudip Nanda, David Allen, Huseng Vefali, Jamshid Shirani
Journal: Circulation (2015)

Background: Ventricular arrhythmias are common in patients supported by left ventricular assist devices (LVAD). However, the benefit of de-novo implantable cardiac defibrillators (ICD) in patients with LVAD is not well established. Methods/Results: The Nationwide Inpatient Sample database identified 12010 LVAD implantations from 2008 to 2012. Among these, 24.8% (n=2975) had a prior ICD while 6.8% (n=614) received an ICD at the time of LVAD implantation. An increase in the rate of ICD implantation during the study period was noted [4.1% in 2008 vs. 6.6% in 2012, p trend = 0.019; adjusted odds ratio (OR) per year= 0.839; 95% confidence interval (CI)= 0.724-0.972]. De-novo ICD implantation was independently associated with reduction in in-hospital mortality in new LVAD recipients [OR=0.141 (95% CI=0.080-0.248); p&lt;0.001]. Patients receiving ICD implants were younger (50.1 vs. 55.8 years, p&lt;0.001). Female sex was an independent negative predictor of ICD implantation [0.601 (0.429- 0.843); p=0.003] and ICD recipients were more likely to be white. Acute myocardial infarction, ventricular tachycardia, ventricular fibrillation (VF), cardiac arrest and atrial fibrillation were independent predictors (p=0.001 for VF; P&lt;0.001 for remainder) of de novo ICD implantation while the etiology of left ventricular dysfunction (ischemic vs. non-ischemic cardiomyopathy) did not predict ICD implantation [OR=0.824 (95% CI=0.593 -1.146); p=0.25]. Conclusion: De novo ICDs were implanted in a small proportion of LVAD recipients. However, it was associated with a significant reduction in in-hospital mortality.
Football’s Toll on Student Athletes
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heart Failure
Authors: Mariell Jessup, Susan Brozena
Journal: New England Journal of Medicine (2003)

Heart failure is a costly and deadly condition that currently affects nearly 5 million Americans. The incidence approaches 10 per 1000 population among persons older than 65 years of age. This review highlights current pathophysiological concepts and discusses available therapies for a range of patients — from those at risk to those with widespread disease.
CMET-26. IN-VITRO &amp; IN-VIVO CULTURE OF PATIENT (PT) DERIVED CSF-CTCS IN LEPTOMENINGEAL DISEASE (LMDZ) FROM MELANOMA TO IDENTIFY NOVEL TREATMENT STRATEGIES
Authors: Vincent Law, Brittany Evernden, John Puskas, Gisela Caceres, Elena Ryzhova, Inna Smalley, Nam Tran, Arnold Etame, Solmaz Sahebjam, Anthony Magliocco, Keiran Smalley, Peter Forsyth
Journal: Neuro-Oncology (2019)

Abstract BACKGROUND Approx. 5% of melanoma pts develop LMDz. There are essentially no models of LMDz available for therapeutic development. Here we report, the in-vitro &amp; in-vivo culturing of CSF-CTCs. METHODS CSF-CTCs were detected by the Veridex CellSearch® System. Cell-free DNA and cell-associated DNA were extracted, sequenced and profiled. Expanded ex-vivo CSF-CTCs were grown in-vitro and tested for drug sensitivity. CSF-CTCs were grown successfully in-vivo from 1 pt; labeled human Braf V600E WM164 cells were injected IT in as a control. RESULTS CSF-CTCs: 12 LMDz pts and 8 melanoma pts without LMDz were studied. All but 1 LMDz pts (92%) had CSF-CTCs (avg: 2148.6; range 23 - 3055 CTCs/ml). In contrast, 3/8 (37%) melanoma Brain Mets pts without LMDz had CSF-CTCs but fewer of them (avg: 0.31; range 0.13 - 0.6 CTCs/ml CSF). CSF-CTCs Profile: These had BrafV600E (83%), and GNAQ Q209P &amp; NRAS Q61R in 1 pt each. Ex-vivoculture of CSF-CTCs and PDX model: After lengthy optimization of conditions we successfully expanded CSF-CTCs in vitro(~25% of pts), and in-vivo in immunodeficient mice from 1 pt (~10% of samples). Ceritinib, used as a FAK inhibitor, with MEKi was effective in-vitro (p=3.17e-6) and prolonged survival in-vivo in LMDz (median survival: &gt;32 days vs control: 18 days; p=7.81e-5). CONCLUSIONS Though the sample size is small, this is the first report of the successful in-vitro &amp; in-vivo culture of CSF-CTCs from pts with LMDz. Single cell analysis to determine how representative these models are and further in-vivo testing are in progress.
Abstract 1410: Clinicopathological characteristics of lung cancer patients with concomitant idiopathic pulmonary fibrosis
Authors: Kota Araki, Kazuhiko Shien, Shunsaku Miyauchi, Akihiro Miura, Yuta Takahashi, Eisuke Kurihara, Yusuke Ogoshi, Kei Namba, Ken Suzawa, Hiromasa Yamamoto, Shuta Tomida, Junichi Soh, Masakiyo Sakaguchi, Shinichi Toyooka
Journal: Cancer Research (2019)

Abstract Background: Idiopathic interstitial pneumonias (IIPs) are diffuse parenchymal lung disease of unknown etiology. Among IIPs, idiopathic pulmonary fibrosis (IPF) is the most frequent subtype. IPF is characterized by the accumulation of activated fibroblasts and extracellular matrix within the parenchyma. IPF is associated with pathologic and radiologic pattern of usual interstitial pneumonia (UIP). There are several possible underlying mechanisms linking lung cancer and IPF, however, many of them are still unknown. The purpose of this study is to reveal the clinicopathological characteristics of lung cancers patients with concomitant IPF. Materials and Methods: The clinical and pathological data of lung cancer patients with IPF who underwent surgical resection of lung cancer between 2001 to 2016 at our institution were analyzed. We defined IPF as IIPs with UIP pattern, based on the chest CT scan and pathological findings. Mutations of EGFR (L858R point mutation and exon19 deletion), AKT1, BRAF, EGFR, KRAS, MEK1, NRAS, PIK3CA, and PTEN were analyzed. Result: A total of 37 patients’ data of lung cancer with concomitant IPF was collected. Two patients had metachronous lung cancers. Thus, we analyzed 39 lung cancers from 37 patients. Based on the radiographic findings, 33 (84.2%) of the available 38 tumors arose from the fibrotic legion, which were mainly observed in peripheral region. The frequency of EGFR mutation was detected in 1 (2.6%) of 39 lung cancers. As control, we had EGFR mutation profile of 583 lung cancer without IPF. For this population, EGFR mutation was found in 164 (28.1%) of 583 cases. There was a significant difference in EGFR mutation between lung cancers with or without IPF (p = 0.0001). Among other examined genes in 16 tumors, one PIK3CA mutation was found. Conclusion: The lung cancer with IPF mainly arouse from fibrotic lesion. The frequency of EGFR mutation was less common in lung cancers with IPF than those without IPF. Our result suggests that molecular profile of lung cancer with IPF is different from that without IPF. Citation Format: Kota Araki, Kazuhiko Shien, Shunsaku Miyauchi, Akihiro Miura, Yuta Takahashi, Eisuke Kurihara, Yusuke Ogoshi, Kei Namba, Ken Suzawa, Hiromasa Yamamoto, Shuta Tomida, Junichi Soh, Masakiyo Sakaguchi, Shinichi Toyooka. Clinicopathological characteristics of lung cancer patients with concomitant idiopathic pulmonary fibrosis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1410.