tbuckley/cabot-search huggingface dataset:
Vitamin E therapy of acute CCl4-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding
Authors: Shu-Ling Liu, Silvia Degli Esposti, Tony Yao, Anna Mae Diehl, Mark A. Zern
Journal: Hepatology (1995)

Oxidative stress, with reactive oxygen intermediate formation, may represent a common mechanism by which liver injury is induced by diverse etiologies. Oxidative stress enhances nuclear factor kappa B (NF- κ B) activity, and NF- κ B activity has been shown to enhance the expression of cytotoxic cytokines. Acute hepatic injury caused by reactive oxygen intermediate production was induced by an intraperitoneal injection of CCl 4 in mice. This injury was significantly inhibited by intravenous pretreatment of the mice with a water-soluble emulsion of α-tocopherol. Alpha-tocopherol treatment of the mice given the CCl 4 also reduced the NF- κ B binding to levels approaching those found in normal mice. In vitro treatment of a monocyte/macrophage cell line with CCl 4 led to enhanced NF- κ B binding and an increase in tumor necrosis factor-α (TNF-α) messenger RNA levels. Liver specimens taken from patients with acute fulminant hepatitis had markedly increased NF- κ B binding activity in comparison with the binding of normal livers. These data demonstrate that abolishing acute hepatic injury with α-tocopherol, a free radical scavenger, also eliminated increased NF- κ B binding. It is tempting to speculate that enhanced NF- κ B expression caused by free radical production/oxidative stress may modulate liver injury, perhaps through an effect on cytotoxic cytokine synthesis. (Hepatology 1995; 22:1474-1481).
The Ready Reference Handbook of Diseases of the Skin.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dislocations and Joint-Fractures.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New and Nonofficial Remedies
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fellowships, Grants, Awards
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Fellowships, Grants, Awards Get access JNCI: Journal of the National Cancer Institute, Volume 86, Issue 24, 21 December 1994, Page 1884, https://doi.org/10.1093/jnci/86.24.1884 Published: 21 December 1994
Thyroid Nodules After High-Dose External Radiotherapy
Authors: Harold T. Pretorius
Journal: JAMA (1982)

From 1974 to 1980, we studied six patients, five treated for Hodgkin's disease and one for a hemangioma, in whom thyroid nodules developed after high-dose (2,500 to 4,000 rad) thyroid radiation. Fine-needle aspiration cytology of the thyroid in five cases showed moderate to severe cellular atypia in four (three of whom had elevated serum thyrotropin levels) and mild atypia in one (who was overtly hypothyroid). In the four with marked atypia, surgical pathology disclosed Hashimoto's thyroiditis in one, diffuse hyperplasia and epithelial atypia in two, and a sclerosing papillary carcinoma in one. Among five patients who had total thyroidectomy, three had carcinoma (microscopic papillary, papillary-follicular, or sclerosing papillary) in addition to one or more follicular adenomas or colloid nodules. Thyroid nodules and neoplasia may be more common than previously appreciated in patients exposed to high-dose radiation. (<i>JAMA</i>1982;247:3217-3220)
Handbuch der Biochemie des Menschen und der Tiere
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pathogenesis of Abelson-Virus- Induced Murine Leukemia&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Siegler, Richard, Zajdel, Shirley, Lane, Ingrid
Journal: JNCI Journal of the National Cancer Institute (1972)

Journal Article Pathogenesis of Abelson-Virus- Induced Murine Leukemia Get access Richard Siegler, Richard Siegler Department of Pathology, Boston University School of Medicine, Boston, Massachusetts 02118 Search for other works by this author on: Oxford Academic PubMed Google Scholar Shirley Zajdel, Shirley Zajdel Department of Pathology, Boston University School of Medicine, Boston, Massachusetts 02118 Search for other works by this author on: Oxford Academic PubMed Google Scholar Ingrid Lane Ingrid Lane Department of Pathology, Boston University School of Medicine, Boston, Massachusetts 02118 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 48, Issue 1, January 1972, Pages 189–218, https://doi.org/10.1093/jnci/48.1.189 Published: 01 January 1972 Article history Received: 20 July 1971 Accepted: 06 October 1971 Published: 01 January 1972
Control and Direction of Allied Health Education
Authors: Margaret L. Moore
Journal: JAMA (1971)

When I was asked to discuss<i>control</i>and<i>direction</i>of allied health education programs—especially with regard to teamwork as well as independent work—I was saddened. To discuss<i>control</i>and<i>direction</i>does not suggest teamwork, and our major need is to<i>plan</i>for services to the public by preparing a sufficient quantity and quality of personnel—personnel who should be working cooperatively to meet the needs of the public. Perhaps we have a hidden agenda and actually are discussing control in a diverse way. We must determine for whom, by whom, and for what purpose control is instituted and for whom and for what purpose education is needed. Control may be exercised by forces—tangible and intangible—and is related to fear, status, and power. Basically, management and direction of a curriculum come through the budget. Four primary areas are involved in the regulatory process: (1) the selection, recognition, rank, and salary of the
Tashima's Syndrome
Authors: C.K. Tashima
Journal: JAMA (1965)

<h3>To the Editor:—</h3> This communication describes a new syndrome, which has never been previously reported in the medical literature. It is called Tashima's syndrome and in its full-blown state (forme fruste manifestations may be described in the future) is defined as a condition in which a physician searches for a new sign, disease, or syndrome to which his name can be attached. In this case it is named after the physician who first described the condition, rather than after the patient with the disease, as was the case with de Musset's sign and Christmas disease. Needless to say, confusion as to whether the eponym applies to patient or physician may arise in the assignment of priority when the patient and the doctor both possess the same name. It is still usually possible to assign the proper designation by using the full name. Weir Mitchell's disease and Foster Kennedy syndrome are
The Drug Spotlight Program
Authors: George N. Aagaard
Journal: JAMA (1973)

The Drug Spotlight Program is a hospital-based program of continuing education in Clinical Pharmacology and Therapeutics. It will suggest actual or potential therapeutic problems that the Pharmacy and Therapeutics Committee of the medical staff may wish to study through a review of hospital records. It will also make available, through JAMA and other participating professional journals, timely and pertinent scientific reports on the problems in question. These reports will be a valuable source of information if the medical staff wishes to conduct an educational program on some aspect of the problem. Cooperating in this program are the following organizations: American Academy of Family Physicians, American College of Physicians, American College of Surgeons, American Hospital Association, American Medical Association, American Nurses Association, American Society for Clinical Pharmacology and Therapeutics, American Society of Hospital Pharmacists, Association of American Medical Colleges, Association for Hospital Medical Education, and Joint Commission on Accreditation of Hospitals.
Plasma exchange therapy for solar urticaria
Authors: P. COLLINS, R. AHAMAT, C. GREEN, J. FERGUSON
Journal: British Journal of Dermatology (1996)

We report two cases of severe idiopathic solar urticaria treated.1 with plasma exchange therapy. Previous treatment which included antihistamines and. in one patient, desensitization with psoralens and ultraviolet A (PUVA) and narrowband ultraviolet B phototherapy produced only partial benefit. The effect of plasma exchange therapy was assessed using monochromator phototesting and intradermal injection of in vitro irradiated serum. One patient responded but relapsed within 2 weeks. We have failed to demonstrate a lasting benefit from plasma exchange therapy (PExT) in the treatment of two patients with idiopathic solar urticaria.
Pancreatic transplantation.
Authors: P J Morris
Journal: BMJ (1972)

This study involved a retrospective analysis of the various factors which may have contributed to the outcome of pancreatic allograft and patient survival in our initial series of 13 segmental pancreatic transplants. Six of these patients received simultaneously renal allografts from the same donor. Pretransplant factors, such as prolonged warm ischemia and hypothermic storage periods greater than 12 hours after harvesting, correlated with an increase in acute post-transplant pancreatic failure. No clear correlation could be established between surgical techniques and final outcome of the pancreatic allograft. Rejection continues to be a major obstacle to achievement of long term pancreatic allograft function, although it was more easily monitored in the combined renal and pancreatic transplant recipients.
Gout in the Bible and Talmud
Authors: Fred Rosner
Journal: JAMA (1969)

<h3>To the Editor:—</h3> The first modern description of gout is attributed to Thomas Sydenham (1624-1689) in his classic work entitled "Tractatus de Podagra et Hydrope." This disease may have already been known, however, in biblical and talmudic times. King Asa of Judah (915-875 BC) reigned happily and peacefully for over 40 years. In his old age, he suffered from a disease in his feet considered to be gout. The key passage is found in I Kings 15:23 where it states: Now the rest of all the acts of Asa and all that he did and the cities which he built, are they not written in the book of chronicles of the Kings of Judah? But in the time of his old age, he was diseased in his feet. The fifth century Babylonian Talmud, in two separate discussions (Tractates Sanhedrin 48b and Sotah 10a), comments on King Asa's illness as follows:
Cefotaxime Failure in Group A Streptococcal Meningitis
Authors: James W. Bass
Journal: JAMA (1983)

<h3>To the Editor.—</h3> The recent report by Iannini and Kunkel inThe Journal(1982;248:1878) warrants critical comment. The authors state that their 80-year-old patient with septic arthritis had "gram-positive cocci in short chains present on a stained smear" of the joint fluid. They then state that "after informed consent, the patient was treated with 2 g of intravenous cefotaxime sodium every six hours." My concern is how well this patient could have been informed if she elected to be treated with a new drug that is at least tenfold less active and at least ten times more expensive than penicillin G sodium against group A streptococci, which should have been presumed as the cause of infection from the Gram stain and confirmed as such within 24 hours. In addition, cefotaxime has a broad range of antimicrobial activity not only unneeded in this patient but also unwanted. Needless suppression of normal
Primary biliary cirrhosis: Relation between hepatic function and pulmonary function in patients who never smoked
Authors: Michael J. Krowka, Patricia M. Grambsch, Eric S. Edell, Denis A. Cortese, Rolland E. Dickson
Journal: Hepatology (1991)

We studied the relationship between selected variables of hepatic and pulmonary function in 47 patients with primary biliary cirrhosis, who were participating in a prospective study to assess sequential pulmonary function at yearly intervals. An additional 20 patients with primary biliary cirrhosis, who were liver transplant candidates awaiting transplantation, were studied. None of the 67 patients ever smoked cigarettes. Severity of primary biliary cirrhosis was characterized by histological stage and the Mayo risk score derived from a Cox regression model that used the following variables: serum bilirubin and serum albumin levels, age, prothrombin time and clinical severity of edema. Pulmonary function assessment included key variables describing expiratory airflow (forced expiratory volume in 1 sec divided by forced vital capacity) and efficiency of gas exchange (steadystate diffusing capacity for carbon monoxide). We found a significant relationship between histological stage of primary biliary cirrhosis and steady-state diffusing capacity (p = 0.02) and between the Mayo risk score for disease severity and steady-state diffusing capacity (p = 0.03). Progressive deterioration of steady-state diffusing capacity was associated with increasing severity of primary biliary cirrhosis. No relationship existed between pulmonary function and the presence of sicca complex or Sjögren's syndrome or the clinical manifestations of portal hypertension (e.g., esophageal varices, ascites and splenomegaly). No significant relationship existed between expiratory airflow and severity of primary biliary cirrhosis. We conclude that in patients with primary biliary cirrhosis who have never smoked, a statistically significant relationship exists between the severity of the liver disease and the efficiency of gas exchange measured by steady-state diffusing capacity. This association is not related to clinical manifestations of portal hypertension, sicca complex or Sjögren's syndrome. (Hepatology 1991;13:1095-1100.)
CLINICAL HISTORY OF THE CASE OF PRESIDENT JAMES ABRAM GARFIELD.
Authors: ROBERT REYBURN
Journal: JAMA (1894)

(<i>Continued from page 549</i>). August 24, 8:30a.m.Temperature 98.5; pulse 100; respirations 17. August 24,12:30p.m.Temperature 99.2; pulse 104; respirations 17. August 24, 6:30 p.m. Temperature 100.7; pulse 108; respirations 19. August 24 8:30a.m.The President passed a very good night awakening at longer intervals than during several nights past. He continues to take liquid food by the mouth with more relish, and in such quantity that the nutritive enemata were suspended for the present. Shortly after the noon bulletin was issued, an incision was made into the swelling on the right side of the President's face for the purpose of relieving the tension of the swollen parotid gland and giving vent to pus, a small quantity of which was evacuated by the operation. The seat of the incision was sprayed with carbolic acid, but no anesthetic was given him, and he bore the operation well. He
Shigellosis Outbreak Associated With an Unchlorinated Fill-and-Drain Wading Pool—Iowa, 2001
Journal: JAMA (2001)

On June 15, 2001, local physicians reported 11 cases of diarrhea to a county health department. Stool samples from two of these persons were culture confirmed as Shigella sonnei, one person was hospitalized. A preliminary investigation found that nine of these persons recently had visited a large city park with a wading pool. The Iowa Department of Public Health was asked to assist in an investigation of this outbreak. This report summarizes the results of the investigation, which implicated the inadequately disinfected wading pool as the source of the outbreak and presents strategies for preventing such outbreaks.
Acute Iron Intoxication in an Adult
Authors: Marc K. Wallack
Journal: JAMA (1974)

ACUTE poisoning from the ingestion of iron salts is common in children; there are more than 2,000 cases annually, with a mortality in untreated patients as high as 45%.<sup>1</sup>However, acute intoxication is rarely seen in adults. There are only two previously reported cases; in both, the ingestion proved fatal.<sup>1,2</sup>In the present case, an overdose of ferrous sulfate, taken in an apparent suicidal gesture, resulted in a moderately severe toxic reaction to iron. The illness progressed through classic stages similar to those noted in children. Of particular interest was a hitherto-unreported electrocardiographic abnormality: deep inversions of precordial T waves. These changes probably represent one of the many metabolic alterations resulting from iron poisoning. <h3>Report of a Case</h3> A 24-year-old black woman was admitted to Montefiore Hospital, University of Pittsburgh Health Center, following an apparent suicide attempt in which she ingested a large dose of ferrous sulfate. She
Kirke's Handbook of Physiology.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial Board and Contents
Authors: Andrew Clark, Gail Teitzel, Paige Shaklee, Fred Kop, Ria Otten, Patrick Scheffmann, Silvia Arber, Anders Björklund, J Paul Bolam, Sarah Bottjer, Barry Dickson, Chris Doe, Craig Garner, Yukiko Goda, Kenneth Harris, Nancy Ip, Meyer Jackson, Maria Karayiorgou, Robert Malenka, Mark Mattson, Freda Miller, Richard Morris, Maiken Nedergaard, Eric Nestler, Hitoshi Sakano, Greg Stuart, Wolf Singer, Marc Tessier-Lavigne, Chris Walsh
Journal: Trends in Neurosciences (2017)
Atlas and Text-Book of Topographic and Applied Anatomy.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal