tbuckley/cabot-search huggingface dataset:
Outpatient treatment of a third degree burn
Authors: R. J. Hasl
Journal: JAMA (1968)

<h3>To the Editor:—</h3> The patient, a 7-month-old Montagnard girl, was brought to the emergency room of an army clearing station at Pleiku, Vietnam, on Aug 23, 1967. Eight days previously the patient had crawled onto the family fire and sustained a serious burn of the lower extremities. The local priest-doctor suggested that nothing be done since the child was going to die, whereupon the mother wrapped the child in burlap cloth, watched her, and continued to breast feed her. On the eighth postburn day a MEDCAP team of the 704th Maintenance Battalion, Pleiku, Vietnam, encountered the child on a routine mission and prevailed upon the mother to bring the baby in for treatment. Examination revealed a healthy appearing 15-lb, afebrile, well hydrated female child with thick black eschar over the anterior aspects of both lower extremities, on the left from the midthigh to the foot, and on the right from
NIH testing sorbinil to prevent diabetic retinopathy
Authors: C. Marwick
Journal: JAMA (1984)

A placebo-controlled trial involving more than 800 patients with type I insulin-dependent diabetes has been started by one of the National Institutes of Health (NIH), Bethesda, Md, to evaluate the use of sorbinil in the prevention of diabetic retinopathy. The study, which admitted the first subjects in March, is being conducted by the NIH's National Eye Institute. The institute plans to follow up the patients for at least 30 months. The project cost has not been announced, but the study is being supported by Pfizer, Inc, New York City, the developer of sorbinil. Diabetic retinopathy occurs in about 4.4 million of the estimated 10 million to 11 million persons with diabetes in the United States. Every year, about 4,700 of these patients become blind. Research studies have suggested that sorbinil may help alleviate retinopathy. Sorbinil is an aldose-reductase inhibitor. Earlier studies on diabetic animals have shown that it can reduce
Minimal genetic findings and their cancer control implications. A family with the cancer family syndrome
Authors: H. T. Lynch
Journal: JAMA (1978)

A kindred in which five first-degree relatives were initially known to exhibit colorectal, endometrial, and unspecified carcinoma for two generations, occurring at an early age and including three cases of multiple primary cancer, is consistent with criteria for the cancer family syndrome. Follow-up included a diligent surveillance program that led to the early diagnosis of colon cancer in a young member of the third generation who had been considered at high risk for this lesion. Manifestly, hereditary cancer syndrome identification may be expedited through longitudinal study of apparently cancer-prone kindreds, given limited historical information about tumor expression. However, cancer surveillance measures can and should be instituted early and predicated on clues that suggest, but need not be diagnostic of, such a hereditary cancer predisposing disorder. (<i>JAMA</i>240:535-538, 1978)
Abo不相容性和抗a / B异凝集素滴度对血液恶性肿瘤清髓处理后输血需求和无关脐带血移植的早期结果的影响
Authors: Yang Chen, Huiru Wang, Zimin Sun, Wen Yao, Huilan Liu, Xiaoyu Zhu, Dongyao Wang
Journal: Blood (2020)
Highlights
Journal: JAMA Dermatology (2014)

Primary Melanoma Detection in Extreme-Risk Setting 819The most important risk factors for melanoma include a predisposing genetic mutation, a history of melanoma, and multiple atypical nevi.The efficacy of various diagnostic screening interventions among these high-risk patients remains uncertain.In this prospective observational study, Moloney et al demonstrate that baseline total body imaging and sequential digital dermoscopy imaging were effective in diagnosing melanoma early in this extreme-risk population.Hypervigilance for difficult-to-detect thick melanoma subtypes was also considered crucial.
GLANDULAR FEVER
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Phase I, open-label, dose escalation study of MGA271 in combination with pembrolizumab in patients with B7-H3-expressing melanoma, squamous cell cancer of the head and neck, or squamous cell non-small cell lung cancer
Authors: Jan Baughman, Deryk Loo, Francine Chen, Paul Moore, Ezio Bonvini, James Vasselli, Jon Wigginton, Roger Cohen
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts MGA271 is an Fc optimized humanized IgG1 monoclonal antibody that binds to B7-H3 (CD276), a member of the B7 family, currently undergoing Phase I testing. The Fc domain is engineered for enhanced binding to the activating FcγR, CD16A, and decreased binding to the inhibitory FcγR
Margaret A. Winker, MD, Comes to JAMA as 12th Fishbein Fellow in Medical Journalism
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manuscripts Approved for JNCI, March–April 1972
Journal: JNCI Journal of the National Cancer Institute (1972)

Journal Article Manuscripts Approved for JNCI, March–April 1972 Get access JNCI: Journal of the National Cancer Institute, Volume 48, Issue 5, May 1972, Pages 1555–1556, https://doi.org/10.1093/jnci/48.5.1555 Published: 01 May 1972
Editorial freedom and integrity
Authors: G. D. Lundberg
Journal: JAMA (1988)

A medical editor has to be a keeper of the conscience of a profession; if he tries to live up to this ideal he will be always getting into trouble. Hugh Clegg, Quondam Editor,<i>British Medical Journal</i><sup>1</sup> At its annual meeting held at the National Library of Medicine in Bethesda, Md, on Sept 10 through 13, the International Committee of Medical Journal Editors (The Vancouver Group) unanimously approved a statement regarding editorial freedom. The members of the group who were present are Edward J. Huth, MD, editor,<i>Annals of Internal Medicine;</i>Kathleen King, MRCPath, editor, the<i>Medical Journal of Australia;</i>Stephen P. Lock, MD, editor, the<i>British Medical Journal;</i>George D. Lundberg, MD, editor,<i>The Journal of the American Medical Association;</i>Magne Nylenna, MD, editor,<i>Tidsskrift for Den Norkse Laegeforening;</i>Arnold S. Relman, MD, editor in chief,<i>New England Journal of Medicine;</i>Dr Povl Riis, editor in chief, Danish
Medical Genetics
Authors: A. G. Motulsky
Journal: JAMA (1989)

Knowledge in the field of human and medical genetics is growing very rapidly. The principal major advance relates to gene mapping. More and more DNA markers are being discovered, which span every one of the 24 human chromosomes. These DNA variants are transmitted by mendelian principles and are not expressed at the phenotypic level.<sup>1</sup>Every person (except for identical twins) is unique in his or her DNA makeup and this individuality can be used for a variety of practical purposes. Paternity determination—already much improved by use of HLA typing— can now be made virtually certain by using DNA markers. Forensic identification of criminals has been revolutionized by DNA technology.<sup>2</sup>A person's unique DNA makeup can be determined from any tissue that contains nucleated cells. DNA "fingerprinting" carried out on sperm or blood specimens left at the scene of a crime is leading to convictions because of the certainty
Challenges Facing Family Practice and Primary Care
Authors: Daphne P. Bicket
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Risks From Antipsychotic Medications in Children and Adolescents
Authors: Christina Mangurian
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Going Home
Authors: Amrapali Maitra
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Somnambulating Into a Paradigm Shift-World Changes: Thomas Kuhn and the Nature of Science
Authors: Harold A. Rashkis
Journal: JAMA (1994)

<h3>To the Editor.</h3> —The very fine review by Richard Manning<sup>1</sup>of<i>World Changes: Thomas Kuhn and the Nature of Science</i>, edited by Paul Horwich, appeared in the same issue of<i>JAMA</i>as a group of letters, "Managed Care, Mental Health, and the Marketplace," relating to a Commentary by Drs Jellinek and Nurcombe.<sup>2</sup>I wondered what Thomas Kuhn would have thought of the debate. Unable to speak for Professor Kuhn, I note his interest in language, communication, paradigm, and paradigm shift. I would suppose him to say that insurers and physicians think and speak from paradigms so dissimilar that communication and the achievement of like-mindedness is impossible. Even if they use the same words (with differing intent), they talk past each other. This is not surprising: insurers are in business and their only purpose is to make increasingly larger profits. Physicians expect to earn a good living but have
The organization of health care
Authors: K. Grumbach
Journal: JAMA (1995)

Frank Hope has walked with a limp since his attack of polio in the 1940s. When he watches his daughter run after her young toddler, he experiences a sense of gratitude that the era of vaccinations has protected his child and grandchild from such a disabling infection. He recalls the sense of excitement that gripped the nation as the Salk polio vaccine was first tested and then adopted into widespread use. In Frank's mind, these types of scientific breakthroughs attest to the wonders of the US health care system. Frank's grandson attends a day-care program. Ruby, a 2-year-old girl in his program, was recently hospitalized for a severe case of measles complicated by pneumonia. She spent 2 weeks in a pediatric intensive care unit, including several days on a respirator. She had not received her measles immunization, normally scheduled for 15 months of age. Ruby's mother works full-time as a
The American Illustrated Medical Dictionary. For Practitioners and Students. A Complete Dictionary of the Terms Used in Medicine, Surgery, Dentistry, Pharmacy, Chemistry and Kindred Branches, Including Much Collateral Information of an Encyclopedic Character, Together with New and Elaborate Tables of Arteries, Muscles, Nerves, Veins, etc.; of Bacilli, Bacteria, Micrococci, Streptococci; Eponymic Tables, Diseases, Operations, Signs and Symptoms, Stains, Tests, Methods of Treatment, etc.
Journal: JAMA (1901)
Genetic Differences in Susceptibility to Chemically Induced Myelotoxicity and Leukemia
Authors: Daniel W. Nebert
Journal: Environmental Health Perspectives (1981)

The Ah locus represents a complex "cluster" of genese controlling the induction of numerous drug-metabolizing enzyme "activities" by polycyclic aromatic compounds. Allelic differences at the Ah locus are reflected in the large differences in inducibility of cytochrome P1-450 and benzo[a]pyrene metabolism in numerous tissues when the mice receive the chemical daily in their diet. This experimental model system offers to the hematologist and clinical pharmacologist a means to study genetic differences in toxic chemical depression of the bone marrow, as well as a potential model to study aplastic anemia and leukemia explainable on a single-gene basis. The genetically "responsive" individual who is at increased risk for cancer caused by subcutaneous or topical or intratracheal polycyclic hydrocarbons is at decreased risk for toxicity of the bone marrow and leukemia caused by oral benzo[a]pyrene (when compared with the genetically "nonresponsive" individual receiving the same dose of the same xenobiotic). In other words, tissue sites in direct contact with the carcinogen develop cancer in responsive animals because of induced P1-450; tissues in distant sites of the body may develop malignancy in nonresponsive animals because more carcinogen reaches that tissue due to decreased P1-450 induction all over the body and therefore decreased detoxication. Not only the dct with the carcinogen develop cancer in responsive animals because of induced P1-450; tissues in distant sites of the body may develop malignancy in nonresponsive animals because more carcinogen reaches that tissue due to decreased P1-450 induction all over the body and therefore decreased detoxication. Not only the dct with the carcinogen develop cancer in responsive animals because of induced P1-450; tissues in distant sites of the body may develop malignancy in nonresponsive animals because more carcinogen reaches that tissue due to decreased P1-450 induction all over the body and therefore decreased detoxication. Not only the dose but the route of administration and the tissue in which the malignancy or toxicity develops are therefore very important in the interpretation of data from tumorigenesis or toxicity experiments involving P1-450 inducers such as polycyclic hydrocarbons. There exists sufficient evidence that heritable variation of the Ah locus occurs in man. Growing evidence indicates that persons with higher aryl hydrocarbon hydroxylase inducibility in their cultured mitogen-activated lymphocytes may have a statistically significantly increased risk for certain types of cancer and drug toxicity. It remains to be determined at the present time, however, whether this genotype can be used as a biochemical marker in the individual patient for predicting increased susceptibility to certain types of environmentally caused cancers or toxicity in man.
Spermatocele: Pathological and Surgical Anatomy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Problem of the So-Called Squamous Cell Nodes in the Endometrium
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gas Physiology in Space Operations
Authors: Emanuel M. Roth
Journal: New England Journal of Medicine (1966)

THE advent of space operations has ushered in a host of physiologic problems. Prominent among these is the selection of space-cabin atmospheres. Because of severe limitation in weight and power available to the spacecraft designer for support of human function, optimization of the atmospheric environment from both the physiologic and the engineering point of view has become a major factor in the planning of manned space programs. The following is a presentation of the significant factors in this man-machine interaction, with emphasis on the role of gas physiology.The basic physiologic and engineering requirements for selection of space-cabin atmospheres have . . .
TV or not TV. Communicating health information to the public
Authors: B. B. Dan
Journal: JAMA (1992)

The invasion of American culture by television may prove to be the defining aspect of our modern times. It is difficult to imagine what our lives would be like without television's presence. Television has not only reflected our history, but to a great extent television has influenced it. It has been estimated that in the 1920s, the average adult in the United States spent only 3 to 4 hours per day using the media (newspapers, magazines, books, radio, and film), but with the advent of television, the time spent on media increased by 40%.<sup>1</sup> See also pp 999 and 1004. On average, Americans have their television sets on for 6 hours and 56 minutes each day (A.C. Nielsen Media Research, New York, NY, 1990-1991), and watching television has become our single most time-consuming leisure activity.<sup>2</sup>In fact, for most Americans, television is the medium from which they receive