tbuckley/cabot-search huggingface dataset:
Benign but fatal: management of endotracheal Rosai-Dorfman disease with acute onset
Authors: Bin Wang, Zhi-min Song, Jin-dong Li, Yin-long Zhao, Ping-li Sun, Jia-kun Tian, Jin-zhi Yin, Yan Zhang
Journal: Thorax (2022)

Rosai-Dorfman disease (RDD) is a non-malignant condition mainly manifesting as a proliferation of histiocytes in lymph nodes. Endotracheal RDD (ERDD) with an acute onset presentation is extremely rare. There are few case reports of ERDD mainly concerning its pathology, diagnostics and bronchoscopic treatment, without providing sufficient clinical information from a comprehensive perspective. As a novel and challenging technique, tracheal resection and reconstruction (TRR) with spontaneous-ventilation video-assisted thoracoscopic surgery (SV-VATS) has been reported as feasible and safe in highly selected patients, but few centres have shared their experience with this approach. This case-based discussion includes not only practical issues in the management of a life-threatening ERDD patient, but also specialists’ views on the management of acute obstructive airway, and the surgeons’ reflection on TRR with SV-VATS.
Diagnosis, prevention and treatment of common shoulder injuries in sport: grading the evidence – a statement paper commissioned by the Danish Society of Sports Physical Therapy (DSSF)
Authors: Behnam Liaghat, Julie Rønne Pedersen, Rasmus Skov Husted, Lisbeth Lund Pedersen, Kristian Thorborg, Carsten B Juhl
Journal: British Journal of Sports Medicine (2022)

This statement paper summarises and appraises the evidence on diagnosis, prevention, and treatment of common shoulder injuries in sports. We systematically searched Medline and Embase. The Grading of Recommendations Assessment, Development and Evaluation tool was applied to evaluate the overall quality of evidence.For diagnosis, we included 19 clinical tests from mixed populations. Tests for anterior instability, biceps-labrum complex injuries and full subscapularis rupture had high diagnostic accuracy (low to moderate quality of evidence).For prevention, the Oslo Sports Trauma Research Center, the Shoulder Control, the FIFA 11+ shoulder injury prevention programmes, and a baseball-specific programme (range of motion, stretching, dynamic stability and strengthening exercises) showed moderate to large effect size in reducing the risk of shoulder injury compared with no intervention (very low to moderate quality of evidence).For treatment, a rehabilitation programme including stretching, ice packs, electrotherapy and compression, and strengthening exercises showed a large effect size in reducing pain and disability compared with no intervention in athletes with subacromial impingement syndrome (very low to moderate quality of evidence). For the treatment of supraspinatus tendinopathy, hyperthermia treatment (heating the skin to 38°C-40°C) resulted in large effect size in reducing pain and disability compared with ultrasound or pendular swinging and stretching exercises (moderate quality of evidence). Strengthening exercise alone or in combination with stretching exercises promoted a large effect in reducing shoulder pain (cohort studies, no comparators) (very low quality of evidence). The quality of evidence for most estimates was low to moderate, indicating that future high-quality research may alter our recommendations for clinical practice.
Stage-specific and location-specific cartilage calcification in osteoarthritis development
Authors: Xiaozhao Wang, Qin Wu, Ru Zhang, Zhang Fan, Wenyue Li, Renwei Mao, Zihao Du, Xudong Yao, Yuanzhu Ma, Yiyang Yan, Wei Sun, Hongwei Wu, Wei Wei, Yejun Hu, Yi Hong, Huan Hu, Yi Wen Koh, Wangping Duan, Xiao Chen, Hongwei Ouyang
Journal: Annals of the Rheumatic Diseases (2022)

This study investigated the stage-specific and location-specific deposition and characteristics of minerals in human osteoarthritis (OA) cartilages via multiple nano-analytical technologies.Normal and OA cartilages were serially sectioned for micro-CT, scanning electron microscopy with energy dispersive X-ray spectroscopy, micro-Raman spectroscopy, focused ion beam scanning electron microscopy, high-resolution electron energy loss spectrometry with transmission electron microscopy, nanoindentation and atomic force microscopy to analyse the structural, compositional and mechanical properties of cartilage in OA progression.We found that OA progressed by both top-down calcification at the joint surface and bottom-up calcification at the osteochondral interface. The top-down calcification process started with spherical mineral particle formation in the joint surface during early-stage OA (OA-E), followed by fibre formation and densely packed material transformation deep into the cartilage during advanced-stage OA (OA-A). The bottom-up calcification in OA-E started when an excessive layer of calcified tissue formed above the original calcified cartilage, exhibiting a calcified sandwich structure. Over time, the original and upper layers of calcified cartilage fused, which thickened the calcified cartilage region and disrupted the cartilage structure. During OA-E, the calcified cartilage was hypermineralised, containing stiffer carbonated hydroxyapatite (HAp). During OA-A, it was hypomineralised and contained softer HAp. This discrepancy may be attributed to matrix vesicle nucleation during OA-E and carbonate cores during OA-A.This work refines our current understanding of the mechanism underlying OA progression and provides the foothold for potential therapeutic targeting strategies once the location-specific cartilage calcification features in OA are established.
Association of in-competition injury risk and the degree of rapid weight cutting prior to competition in division I collegiate wrestlers
Authors: Erin Hammer, Jennifer L Sanfilippo, Gary Johnson, Scott Hetzel
Journal: British Journal of Sports Medicine (2022)

Weight cutting is thought to offer a competitive advantage in wrestling. Dehydration has deleterious effects on physical and cognitive function, which may increase the risk of injury. The purpose of the study was to investigate whether the degree of weight cutting was associated with injury risk.Data were collected prospectively in a cohort of collegiate wrestlers over seven seasons. Changes in weight, body fat and lean mass were measured during the preseason, at midseason and before competition. Cox proportional-hazard ratios were calculated for risk of in-competition injury.Among 67 unique division 1 collegiate wrestlers (163 athlete seasons), there were 53 unique injuries affecting 46 athletes. There was no difference in absolute weight change, per cent weight change, per cent body fat change or per cent lean mass change between injured and non-injured wrestlers from the preseason to midseason measurements. From midseason to competition weight, change in body weight was -7.0%±3.2% (-5.3 kg±2.6) in injured athletes compared with -5.7%±3.3% (-4.3 kg±2.5) in non-injured athletes. For every kilogram of body weight lost, wrestlers had a 14% increased hazard of injury (HR 1.14, 95% CI 1.04 to 1.25, p=0.004). For every 1% of body weight lost, wrestlers had an 11% increased hazard of injury (HR 1.11, 95% CI 1.03 to 1.19, p=0.005).Rapid weight cutting was associated with a higher risk of in-competition injuries in division 1 collegiate wrestlers. For every per cent in body weight lost, wrestlers had an 11% increased hazard of injury during competition.
Tenderness and radiographic progression in rheumatoid arthritis and psoriatic arthritis
Authors: Irina Gessl, Claudia A Hana, Thomas Deimel, Martina Durechova, Miriam Hucke, Victoria Konzett, Mihaela Popescu, Paul Studenic, Gabriela Supp, Michael Zauner, Josef S Smolen, Daniel Aletaha, Peter Mandl
Journal: Annals of the Rheumatic Diseases (2022)

The aim of this study was to assess the predictive value of tenderness in the absence of swelling with consideration of other potential risk factors for subsequent radiographic progression in rheumatoid arthritis (RA) and psoriatic arthritis (PsA).Clinical and sonographic (grey scale and power Doppler (PD)) examination of 22 joints of the hand were performed in patients with RA and PsA. The impact of tenderness on progression after 2 years was analysed in non-swollen joints for RA and PsA separately with multilevel mixed logistic regression analysis.We included 1207 joints in 55 patients with RA and 352 joints in 18 patients with PsA. In RA, tenderness was associated with radiographic progression after 2 years (model 2: OR 1.85 (95% CI 1.01 to 3.27), p=0.047), although the association of PD (OR 2.92 (95% CI 1.71 to 5.00), p<0.001) and erosions (OR 4.74 (95% CI 2.44 to 9.23), p<0.001) with subsequent structural damage was stronger. In PsA, we found a positive but not significant association between tenderness and radiographic progression (OR 1.72 (95% CI 0.71 to 4.17), p=0.23). In contrast, similarly to RA, erosions (OR 4.62 (95% CI 1.29 to 16.54), p=0.019) and PD (OR 3.30 (95% CI 1.13 to 9.53), p=0.029) had a marked effect on subsequent structural damage.Our findings imply that tenderness in non-swollen joints in RA is associated with subsequent damage. In both diseases, additional risk factors, such as sonographic signs for synovitis and baseline radiographic damage are associated with radiographic progression.
Small extracellular vesicles derived from hypoxic preconditioned dental pulp stem cells ameliorate inflammatory osteolysis by modulating macrophage polarization and osteoclastogenesis
Authors: Jun Tian, Weiyang Chen, Yuhua Xiong, Qianer Li, Siyi Kong, Mengjie Li, Chunfeng Pang, Yu Qiu, Zhezhen Xu, Qimei Gong, Xi Wei
Journal: Bioactive Materials (2022)

Extensive macrophage inflammatory responses and osteoclast formation are predominant during inflammatory or infective osteolysis. Mesenchymal stem cell (MSC)-derived small extracellular vesicles (MSC-sEV) have been shown to exert therapeutic effects on bone defects. However, cultured MSCs are typically exposed to normoxia (21% O2) in vitro, which differs largely from the oxygen concentration in vivo under hypoxic conditions. It is largely unknown whether sEV derived from dental pulp stem cells (DPSCs) cultured under hypoxic conditions (Hypo-sEV) exert better therapeutic effects on lipopolysaccharide (LPS)-induced inflammatory osteolysis than those cultured under normoxic conditions (Nor-sEV) by simultaneously inhibiting the macrophage inflammatory response and osteoclastogenesis. In this study, we show that hypoxia significantly induces the release of sEV from DPSCs. Moreover, Hypo-sEV exhibit significantly improved efficacy in promoting M2 macrophage polarization and suppressing osteoclast formation to alleviate LPS-induced inﬂammatory calvarial bone loss compared with Nor-sEV. Mechanistically, hypoxia preconditioning markedly alters the miRNA profiles of DPSC-sEV. MiR-210-3p is enriched in Hypo-sEV, and can simultaneously induce M2 macrophage generation and inhibit osteoclastogenesis by targeting NF-κB1 p105, which attenuates osteolysis. Our study suggests a promising potential for hypoxia-induced DPSC-sEV to treat inﬂammatory or infective osteolysis and identifies a novel role of miR-210-3p in concurrently hindering osteoclastogenesis and macrophage inflammatory response by inhibiting NF-kB1 expression.
Reirradiation for Recurrent Glioblastoma: What We Know and What We Do Not
Authors: Jonathan P.S. Knisely, Howard A. Fine
Journal: Journal of Clinical Oncology (2022)

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice.
Randomized Study of Temozolomide or Temozolomide and Capecitabine in Patients With Advanced Pancreatic Neuroendocrine Tumors (ECOG-ACRIN E2211)
Authors: Pamela L. Kunz, Noah T. Graham, Paul J. Catalano, Halla S. Nimeiri, George A. Fisher, Teri A. Longacre, Carlos J. Suarez, Brock A. Martin, James C. Yao, Matthew H. Kulke, Andrew E. Hendifar, James C. Shanks, Manisha H. Shah, Mark M. Zalupski, Edmond L. Schmulbach, Diane L. Reidy-Lagunes, Jonathan R. Strosberg, Peter J. O'Dwyer, Al B. Benson
Journal: Journal of Clinical Oncology (2022)

Patients with advanced pancreatic neuroendocrine tumors (NETs) have few treatment options that yield objective responses. Retrospective and small prospective studies suggest that capecitabine and temozolomide are associated with high response rates (RRs) and long progression-free survival (PFS).
Prognostic Value of Right Ventricular Function in Patients With Suspected Myocarditis Undergoing Cardiac Magnetic Resonance
Authors: Benedikt Bernhard, Aaron Schnyder, Davide Garachemani, Kady Fischer, Giulin Tanner, Yasaman Safarkhanlo, Anselm W. Stark, Jonathan Schütze, Maryam Pavlicek-Bahlo, Simon Greulich, Caroline Johner, Andreas Wahl, Dominik C. Benz, Raymond Y. Kwong, Christoph Gräni
Journal: JACC. Cardiovascular imaging (2022)
Changes in Right Ventricular–to–Pulmonary Artery Coupling After Transcatheter Edge-to-Edge Repair in Secondary Mitral Regurgitation
Authors: Marianna Adamo, Riccardo Maria Inciardi, Daniela Tomasoni, Lucia Dallapellegrina, Rodrigo Estévez-Loureiro, Davide Stolfo, Laura Lupi, Edoardo Pancaldi, Antonio Popolo Rubbio, Cristina Giannini, Tomás Benito-González, Felipe Fernández-Vázquez, Berenice Caneiro-Queija, Cosmo Godino, Andrea Munafò, Isaac Pascual, Pablo Avanzas, Simone Frea, Paolo Boretto, Vanessa Moñivas Palomero, Maria del Trigo, Elena Biagini, Alessandra Berardini, Luis Nombela-Franco, Pilar Jimenez-Quevedo, Erik Lipsic, Francesco Saia, Anna Sonia Petronio, Francesco Bedogni, Gianfranco Sinagra, Marco Guazzi, Adriaan Voors, Marco Metra
Journal: JACC. Cardiovascular imaging (2022)
CT-Guided Direct Current Cardioversion for Atrial Arrhythmias During the COVID-19 Pandemic
Authors: Mahdi Veillet-Chowdhury, Ghaith Sharaf Dabbagh, Stewart M. Benton, April M. Hill, Jefferson H. Lee, Matthew J. Singleton, Gregory P. Fazio, James E. Harvey, Habib Samady, David Singh, Mohammed Y. Khanji, Saman Nazarian, Francesca Pugliese, Edmond Obeng-Gyimah, Brian T. Schuler, C. Anwar A. Chahal
Journal: JACC. Cardiovascular imaging (2022)
Mitral Annular Disjunction Assessed Using CMR Imaging
Authors: Dasa Zugwitz, Kenneth Fung, Nay Aung, Elisa Rauseo, Celeste McCracken, Jackie Cooper, Saloua El Messaoudi, Robert H. Anderson, Stefan K. Piechnik, Stefan Neubauer, Steffen E. Petersen, Robin Nijveldt
Journal: JACC. Cardiovascular imaging (2022)

Mitral annular disjunction is the atrial displacement of the mural mitral valve leaflet hinge point within the atrioventricular junction. Said to be associated with malignant ventricular arrhythmias and sudden death, its prevalence in the general population is not known.The purpose of this study was to assess the frequency of occurrence and extent of mitral annular disjunction in a large population cohort.The authors assessed the cardiac magnetic resonance (CMR) images in 2,646 Caucasian subjects enrolled in the UK Biobank imaging study, measuring the length of disjunction at 4 points around the mitral annulus, assessing for presence of prolapse or billowing of the leaflets, and for curling motion of the inferolateral left ventricular wall.From 2,607 included participants, the authors found disjunction in 1,990 (76%) cases, most commonly at the anterior and inferior ventricular wall. The authors found inferolateral disjunction, reported as clinically important, in 134 (5%) cases. Prolapse was more frequent in subjects with disjunction (odds ratio [OR]: 2.5; P = 0.02), with positive associations found between systolic curling and disjunction at any site (OR: 3.6; P < 0.01), and systolic curling and prolapse (OR: 71.9; P < 0.01).This large-scale study shows that disjunction is a common finding when using CMR. Disjunction at the inferolateral ventricular wall, however, was rare. The authors found associations between disjunction and both prolapse and billowing of the mural mitral valve leaflet. These findings support the notion that only extensive inferolateral disjunction, when found, warrants consideration of further investigation, but disjunction elsewhere in the annulus should be considered a normal finding.
Comprehensive Evaluation of Left Ventricle Dysfunction by a New Computed Tomography Scanner
Authors: Daniele Andreini, Edoardo Conte, Saima Mushtaq, Eleonora Melotti, Carlo Gigante, Maria Elisabetta Mancini, Marco Guglielmo, Gerardo Lo Russo, Andrea Baggiano, Andrea Annoni, Alberto Formenti, Alessandra Magini, Gianluca Pontone, Piergiuseppe Agostoni, Antonio L. Bartorelli, Mauro Pepi, Yoshinobu Onuma, Patrick W. Serruys
Journal: JACC. Cardiovascular imaging (2022)
Quantitative Echocardiographic Assessment and Optimal Criteria for Early Intervention in Asymptomatic Tricuspid Regurgitation
Authors: Emmanuel Akintoye, Tom Kai Ming Wang, Michael Nakhla, Adel Hajj Ali, Agostina M. Fava, Kevser Akyuz, Zoran B. Popovic, Gosta B. Pettersson, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Journal: JACC. Cardiovascular imaging (2022)
Left Ventricular Global Longitudinal Strain and its Prognostic Significance After Kidney Transplantation
Authors: Darae Kim, Minjeong Kim, Jae Berm Park, Juhan Lee, Kyu Ha Huh, Geu-Ru Hong, Jong-Won Ha, Jin-Oh Choi, Chi Young Shim
Journal: JACC. Cardiovascular imaging (2022)
Direct Risk Assessment From Myocardial Perfusion Imaging Using Explainable Deep Learning
Authors: Ananya Singh, Robert J.H. Miller, Yuka Otaki, Paul Kavanagh, Michael T. Hauser, Evangelos Tzolos, Jacek Kwiecinski, Serge Van Kriekinge, Chih-Chun Wei, Tali Sharir, Andrew J. Einstein, Mathews B. Fish, Terrence D. Ruddy, Philipp A. Kaufmann, Albert J. Sinusas, Edward J. Miller, Timothy M. Bateman, Sharmila Dorbala, Marcelo Di Carli, Joanna X. Liang, Cathleen Huang, Donghee Han, Damini Dey, Daniel S. Berman, Piotr J. Slomka
Journal: JACC. Cardiovascular imaging (2022)
Comprehensive Follow-Up Cardiac Magnetic Resonance of Patients With Myocardial Infarction With Nonobstructive Coronary Arteries
Authors: Jannike Nickander, Christina Ekenbäck, Stefan Agewall, Elin Bacsovics Brolin, Kenneth Caidahl, Kerstin Cederlund, Olov Collste, Maria Daniel, Jens Jensen, Shams Y-Hassan, Loghman Henareh, Claes Hofman-Bang, Patrik Lyngå, Eva Maret, Nondita Sarkar, Jonas Spaak, Oscar Winnberg, Martin Sundqvist, Martin Ugander, Per Tornvall, Peder Sörensson
Journal: JACC. Cardiovascular imaging (2022)
Extracellular Volume Fraction by Computed Tomography Predicts Long-Term Prognosis Among Patients With Cardiac Amyloidosis
Authors: Francisco Gama, Stefania Rosmini, Steve Bandula, Kush P. Patel, Paolo Massa, Catalina Tobon-Gomez, Karolin Ecke, Tyler Stroud, Mark Condron, George D. Thornton, Jonathan B. Bennett, Ashutosh Wechelakar, Julian D. Gillmore, Carol Whelan, Helen Lachmann, Stuart A. Taylor, Francesca Pugliese, Marianna Fontana, James C. Moon, Philip N. Hawkins, Thomas A. Treibel
Journal: JACC. Cardiovascular imaging (2022)
Motorized spiral enteroscopy-assisted ERCP in surgically altered anatomy: early experience from a retrospective cohort study
Authors: Markus Schneider, Jörg Höllerich, Christian Gerges, Nicole Balasus, Horst Neuhaus, Torsten Beyna
Journal: Endoscopy (2022)

Background Motorized spiral enteroscopy (MSE) was recently introduced into clinical practice. The aim of the current study was to evaluate the feasibility and safety of MSE for biliopancreatic interventions in patients with surgically altered anatomy. Methods Patients with surgically altered anatomy receiving MSE-assisted ERCP at a single, endoscopy referral center were retrospectively enrolled between January 2016 and June 2021. Results 36 patients (14 female, 22 male), median age 67 years (range 43–88), with biliary (n = 35) and pancreatic (n = 1) indications for MSE-ERCP, were enrolled. The majority (75.0 %) had relevant comorbidities (American Society of Anesthesiologists class III). Surgical reconstruction included Roux-en-Y (n = 30) and Billroth II (n = 6). Technical success rates for enteroscopy, cannulation, and interventions were 86.1 %, 83.9 %, and 100 %, respectively. The overall MSE-ERCP success rate was 72.2 %. One major complication occurred (2.8 %; delayed post-sphincterotomy bleeding). Conclusions This is the first study to demonstrate the feasibility and safety of MSE-assisted ERCP in postsurgical patients with altered anatomy at an expert center. These data justify further evaluation of this new technique, preferably in a prospective multicenter trial.
Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial
Authors: Saye H Khoo, Richard FitzGerald, Geoffrey Saunders, Calley Middleton, Shazaad Ahmad, Christopher J Edwards, Dennis Hadjiyiannakis, Lauren Walker, Rebecca Lyon, Victoria Shaw, Pavel Mozgunov, Jimstan Periselneris, Christie Woods, Katie Bullock, Colin Hale, Helen Reynolds, Nichola Downs, Sean Ewings, Amanda Buadi, David Cameron, Thomas Edwards, Emma Knox, I'ah Donovan-Banfield, William Greenhalf, Justin Chiong, Lara Lavelle-Langham, Michael Jacobs, Josh Northey, Wendy Painter, Wayne Holman, David G Lalloo, Michelle Tetlow, Julian A Hiscox, Thomas Jaki, Thomas Fletcher, Gareth Griffiths, Nicholas Paton, Fred Hayden, Janet Darbyshire, Amy Lucas, Ulrika Lorch, Andrew Freedman, Richard Knight, Stevan Julious, Rachel Byrne, Ana Cubas Atienzar, Jayne Jones, Chris Williams, Anna Song, Jan Dixon, Anja Alexandersson, Parys Hatchard, Emma Tilt, Andrew Titman, Ale Doce Carracedo, Vatsi Chandran Gorner, Andrea Davies, Louis Woodhouse, Nicola Carlucci, Emmanuel Okenyi, Marcin Bula, Kate Dodd, Jennifer Gibney, Lesley Dry, Zalina Rashid Gardner, Amin Sammour, Christine Cole, Tim Rowland, Maria Tsakiroglu, Vincent Yip, Rostam Osanlou, Anna Stewart, Ben Parker, Tolga Turgut, Afshan Ahmed, Kay Starkey, Sujamole Subin, Jennifer Stockdale, Lisa Herring, Jonathon Baker, Abigail Oliver, Mihaela Pacurar, Dan Owens, Alistair Munro, Gavin Babbage, Saul Faust, Matthew Harvey, Danny Pratt, Deepak Nagra, Aashish Vyas
Journal: The Lancet Infectious Diseases (2022)