POS0213-HPR ESTIMATING REPLACEMENT OF SEDENTARY TIME WITH LIGHT AND MODERATE INTENSITY PHYSICAL ACTIVITY TO REDUCE CHRONIC MUSCULOSKELETAL PAIN AND FUNCTIONAL LIMITATION IN THE GENERAL POPULATION: THE JOHNSTON COUNTY HEALTH STUDY
Authors: D. White, L. Arbeeva, B. Cleveland, J. Jakiela, T. Bye, T. Walker, S. Savage-Guin, Y. Golightly
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Chronic musculoskeletal pain (CMP) is a major public health issue given its high prevalence and negative consequences on pain and physical function. One potential approach to mitigate the symptoms of CMP is to replace sedentary time (<i>i.e</i>, sitting and resting during waking hours) with light intensity (<i>e.g.</i>, playing cards or light cooking) or moderate intensity <i>(e.g.</i>, brisk walking) activity. Little is known, however, about what intensity of physical activity (light or moderate) may be needed to replace sedentary behaviors in order to reduce CMP and functional limitation. <h3>Objectives</h3> The purpose of this study was to model replacement of sedentary time with light- and moderate-intensity physical activity and explore its association with reducing risk of CMP and functional limitation in adults from a large general population cohort. <h3>Methods</h3> We used cross-sectional data from the Johnston County Health Study (JoCoHS), which is actively enrolling adults 35-70 years of age from the general population of Johnston County, North Carolina, USA. Physical activity data measured with a hip-worn ActiGraph GT3X monitor were collected over 7 days. We applied standard methods for processing and classifying time spent in sedentary, light, and moderate physical activity. Our study outcomes included CMP, defined as having at least moderate pain on most days of any one month in the last 12 months in any joint, and functional limitation defined as having a walking speed in the slowest sex-specific tertile, which was &lt; 0.6 m/s. We calculated Odds Ratios (OR) with 95% confidence intervals (CI) using logistic regression with Isotemporal Substitution of exposure terms for each intensity of physical activity (light or moderate) and sedentary time. ORs were adjusted for age, sex, and BMI. <h3>Results</h3> As of 12/15/2022, 414 adults had complete clinical and physical activity data (age [mean] (sd) 55.5 years (9.5), BMI 32.9 (8.1), 68% women, 23% Black), 74% had CMP and 33% had functional limitation. Average sedentary time was 9.1 hours/day. Modeling replacement of 10 min/day of sedentary time with 10 min/day of light intensity activity was not associated with CMP (adjusted OR 0.99, 95% CI [0.99, 1.02]), but did reduce the odds of functional limitation by 3% which met statistical significance (adjusted OR 0.97, 95% CI [0.94, 1.00]). Modeling replacement of 10 min/day of sedentary time with 10 min/day of moderate intensity activity reduced the odds of CMP by 11% (adjusted OR 0.89, 95% CI [0.80, 1.00]), and reduced the odds of functional limitation by 12%, though narrowly missing statistical significance (adjusted OR 0.88, 95% CI [0.76. 1.01]). <h3>Conclusion</h3> Substituting light intensity activity for sedentary time was associated with a lower occurrence of functional limitation, but not CMP. Substituting moderate intensity for sedentary time was associated with less CMP with a trend for less functional limitation. These preliminary findings suggest that participation in moderate intensity physical activity may have stronger protective effects for CMP and functional limitation than light intensity physical activity. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> Daniel White Speakers bureau: Paid speaking for Viatris, Liubov Arbeeva: None declared, Becki Cleveland: None declared, Jason Jakiela: None declared, Tom Bye: None declared, Tessa Walker: None declared, Serena Savage-Guin: None declared, Yvonne Golightly: None declared.