tbuckley/cabot-search huggingface dataset:
Abstract 5173: Development of a novel tunable synthetic 3D hydrogel platform for the study of tumor and stromal cell interactions
Authors: Hsu-Kun Wang, Vi Chu, Nick Asbrock
Journal: Cancer Research (2019)

Abstract Numerous cancer cell models exist used to investigate disease mechanisms and to screen potential cancer therapeutics. Roughly 90% of promising preclinical drugs fail to result in efficacious human treatments. Traditional two-dimensional (2D) tissue culture models lack realistic complexity, while animal models are expensive, time consuming, and too frequently fail to reflect human tumor biology. Recently, three-dimensional (3D) cell culture models are a new method to generate new drug candidates before moving to expensive and time-consuming animal models. We have developed a biochemically defined hydrogel platform formed by mixing various polymers with chemical crosslinkers with enhanced functionality. The hydrogel system employs one of two types of backbone polymers: a synthetic non-degradable polyvinyl alcohol (PVA) or an enzymatically-degradable dextran. Both polymers are functionalized either with fast or slow thiol-reactive groups. Crosslinkers consist of either PEG non-cell-degradable or a CD cell-degradable crosslinkers containing peptide sequences that create cleavage sites for matrix metalloproteases (MMPs) that allow cell migration. The technology provides mechanical and biochemical cues to investigate both morphological and physiological properties of cells in a 3D environment. The hydrogel allows precise control over hydrogel stiffness, gelation speed, cell migration and allows cell recovery for downstream applications. Here, we demonstrate the utility of this hydrogel platform to grow epithelial, fibroblast and tumor cells in 3D cell cultures with high cell viabilities and functionalities. Furthermore, we have constructed a 3D tumor/stromal cell co-culture using the hydrogel to model the dynamic tumor cell microenvironment. This technology will allow the creation of more accurate 3D cancer cell models for basic research and drug discovery applications. Note: This abstract was not presented at the meeting. Citation Format: Hsu-Kun Wang, Vi Chu, Nick Asbrock. Development of a novel tunable synthetic 3D hydrogel platform for the study of tumor and stromal cell interactions [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5173.
Food for Thought
Authors: Sunil Badve
Journal: Annals of Internal Medicine (2005)

On Being a Doctor19 July 2005Food for ThoughtSunil Badve, MDSunil Badve, MDFrom Mumbai, India.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-2-200507190-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In August 1996, I joined Lokmanya Tilak Municipal General Hospital (LTMGH) in Mumbai, India, as an internist–house officer. The LTMGH is well-known for handling medical crises, because it is the largest public hospital in Mumbai Suburban District and is located near Asia's largest slum, Dharavi. Initially, I had a difficult time managing the huge workload. One of the central tasks of the housestaff was to discharge as many patients as possible on preemergency days to make room for the many anticipated admissions on call days. The housestaff who kept their ward census in single digits were most valued. Those who ... Author, Article, and Disclosure InformationAffiliations: From Mumbai, India.Corresponding Author: Sunil Badve, MD, The Ottawa Hospital, 1967 Riverside Drive, Ottawa ON K1H 7W9 Canada; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA dual-polarized biconical antenna for direction finding applications from 2 to 18 GHz 19 July 2005Volume 143, Issue 2Page: 149KeywordsAntimalarialsChildrenFeversFoodHeartRenal diseasesRenal failureRenal transplantationStomachTreatment guidelines ePublished: 19 July 2005 Issue Published: 19 July 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Calcium channel blocker use and gastrointestinal tract bleeding among older adults
Authors: Robert C Kaplan, Susan R Heckbert, Thomas D Koepsell, Frits R Rosendaal, Curt D Furberg, Lawton S Cooper, Bruce M Psaty
Journal: Circulation (2001)

P56 Previous studies suggest that calcium channel blockers (CCBs) may be associated with bleeding complications. We examined the association between CCB use and hospitalization for gastrointestinal (GI) tract bleeding among hypertensive older adults in the Cardiovascular Health Study (CHS). Within the CHS population of adults &gt;=65 years old, a cohort of pharmacologically-treated hypertensive individuals was identified (n=2,189 at baseline). Hospitalized GI tract bleeding events during follow-up (n=121) were identified using computerized data and validated using medical records. Information on medication use and other risk factors for bleeding was assessed at yearly examinations. The adjusted hazard ratio (HR) was estimated using Cox proportional hazards regression with time-dependent predictor variables. Compared with use of other antihypertensive medications, use of CCBs was associated with a HR of 1.37 (95 % confidence interval (CI) = 0.95-1.98) for any hospitalized GI tract bleeding, after adjustment for age and cardiovascular disease status. Further adjustment for other known risk factors for GI tract bleeding had little effect. The HRs associated with each of the major CCB subclasses and release formulations were similar. Subjects who used the lowest daily doses of CCBs had the highest risk. The HR associated with CCB use was 1.32 for upper GI tract bleeding (95% CI = 0.82-2.13), 1.19 for lower GI tract bleeding (95% CI = 0.64-2.23), 1.49 for peptic ulcer-related bleeding (95% CI = 0.70-3.20), and 1.98 for “life-threatening” bleeding (95% CI = 1.08-3.63). In this study, the HR associated with CCB use was consistent with a moderately elevated risk of hospitalized GI tract bleeding but was not significantly different from the null. Ongoing clinical trials will help to clarify whether CCBs cause bleeding complications.
Correction
Journal: BMJ (1935)

Car Replacement E. M. D." bought a second-hand car in 1933 for £50.In 1934 he sold it for £30 and bought a new car for £175.No depreciation has been allowed.What can be claimed for replacement?* The amount allowable is the net cost of replacing the car by another of similar standard and condition, and is therefore £50 -£30 = £20." E. M. D." mentions that the local inspector " does not allow depreciation."It
Treatment of Disease. A Manual of Practical Medicine.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Planning and managing new and complex medical and surgical procedures
Authors: J. M. Long
Journal: JAMA (1966)

Traditionally, the only problems involved with medical and surgical procedures have been those more or less directly related to medicine. With the recent development of rather complex procedures such as organ transplants, another type of problem has arisen, namely, the planning and management of the procedure. We believe that the planning and management problem will increase and become a limiting factor in the development of more complex procedures. Computerized planning and management techniques are available to assist in the problem. Among these techniques is a procedure known originally as the critical path method (CPM).<sup>1</sup>Another, similar technique was later devised which is somewhat more elaborate known as the program evaluation and review technique (PERT).<sup>2</sup>The authors have attempted to evaluate these programs to see if they would be useful in the planning and managing of new and complex surgical procedures. In order to do this, we have applied
Autonomic Disorders
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human Exposures to Mutagens: An Analysis Using the Genetic Activity Profile Database
Authors: R. R. Tice, H. F. Stack, M. D. Waters
Journal: Environmental Health Perspectives (1996)

The Genetic Activity Profile (GAP) database was used to identify and compare agents showing genotoxic activity in humans.The database revealed several substances for which both human and rodent cytogenetic data existed.Based on the ratio of the lowest effective doses (LEDs) in rodent versus human studies, humans appear to be at least 10 times more sensitive than rodents to the majority of the genotoxic substances examined.Several caveats are discussed which may be responsible, in part, for the apparent differences in sensitivity.Some of these differences could be due to variations in the test protocols or they may, in fact, reflect real differences between human and rodent cells.However, in contrast to the in vivo comparison, the LEDs for human data from in vitro studies were not uniformly lower than for comparable studies in rodents.The in vitro comparison suggests that the apparent differences in human versus rodent cell sensitivity seen in vivo must be viewed with a degree of caution.Nevertheless, the overall GAPs for these agents, and particularly the human in vivo data, underscore the concern for adequate protection of humans exposed to these environmental mutagens.Environ Health Perspect 104(Suppl 3):585-589 (1996) Key words: chemical potency,
The school nurse practitioner program. A new and expanded role for the school nurse
Authors: H. K. Silver
Journal: JAMA (1971)

The school nurse practitioner program is a new educational and training program in pediatric health care for professional nurses which prepares school nurses to assume an expanded role in providing improved health care to school-aged children. School nurses will be prepared to offer comprehensive well-child care and to identify and assess the factors that may operate to produce learning disorders, psychoeducational problems, perceptive-cognitive difficulties, and behavior problems as well as those causing physical disease. The school will serve as a principal setting for comprehensive primary and continuing health care and services since it is the one place where children between the ages of 5 and 18 years are regularly and readily accessible. Effective utilization of nurses in a school setting could result in a major modification of the present health-care system.
Serum Calcium and Phosphorus in Infancy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Herpes zoster ophthalmicus and delayed contralateral hemiparesis. Relationship of the syndrome to central nervous system granulomatous angiitis
Authors: G. J. Gilbert
Journal: JAMA (1974)

A stereotyped syndrome exists in which herpes zoster ophthalmicus is followed in three to five weeks by acute contralateral hemiparesis or aphasia. The first case, to our knowledge, in which angiographic studies of the great vessels in the neck and intracranial arteries were done showed a segmental arteritis of the carotid siphon. The literature on the disease granulomatous angiitis of the central nervous system includes two typical cases of herpes zoster ophthalmicus with contralateral hemiplegia that were not clinically recognized as such. However, autopsy showed a segmental ipsilateral arteritis diagnostic of granulomatous angiitis of the nervous system. At least some cases of granulomatous angiitis of the nervous system are due to segmental arteritis by varicella virus, and the pathological basis of the syndrome of herpes zoster ophthalmicus with contralateral hemiplegia is a segmental granulomatous angiitis. (<i>JAMA</i>229:302-304, 1974)
Physicians and nuclear war
Authors: B. Lown
Journal: JAMA (1981)

THE WORLD is moving inexorably toward the use of nuclear weapons. The atomic age and space flights demonstrate the awesome power of science and technology. These developments have also brought humankind to a bifurcation—one road of unlimited opportunity for improving the quality of life, the other of unmitigated misery, devastation, and death. The road we follow will determine whether modern society has a future. <h3>The Experience of Hiroshima</h3> In Hiroshima, a primitive uranium bomb with an explosive power of 13 kilotons (equivalent to 13,000 tons of TNT) instantaneously killed more than 75,000 persons. Of a population of 245,000, more than 100,000 persons were injured. Ninety percent of the 76,000 buildings within city limits were destroyed. Only three of Hiroshima's 45 hospitals were left unscathed. Fewer than 30 of the 150 physicians were available to attend the thousands of victims. Of the 1,780 nurses, only 126 were alive and able to
Abstract 4356: Menin and ATF4 cooperate to drive serine biosynthesis in Ewing sarcoma
Authors: Jennifer Jimenez, Laurie K. Svoboda, Sudha Sud, Samuel Kerk, Jolanta Grembecka, Costas A. Lyssiotis, Elizabeth R. Lawlor
Journal: Cancer Research (2019)

Abstract Ewing sarcoma (ES) is an aggressive bone and soft tissue tumor. We previously reported that the scaffolding protein menin is overexpressed by ES, and that menin inhibition results in impaired ES cell proliferation, survival, and tumorgenicity. Additionally, our recent studies revealed a previously undescribed role for menin in the activation of the serine biosynthetic pathway (SSP), a critical metabolic pathway that is aberrantly activated in many human cancers. The biologic functions of menin are largely determined by its protein-binding partners, the best characterized of which is the histone methyltransferase MLL. In the current study, we are investigating the mechanistic link between menin and the SSP to determine whether menin activates the SSP via epigenetic trithorax complexes. Our data show that the core SSP enzymes, PHGDH, PSAT1, and PSPH are highly expressed by ES. Moreover, expression of all three genes is highly correlated in primary tumors, suggesting that they may be coordinately regulated by an upstream factor. In other cancer types, activation of the SSP has been shown to result from amplification of the PHGDH locus or activation of the master transcriptional regulator, ATF4. We have found that PHGDH is not amplified in ES but ATF4 is overexpressed, and ATF4 loss of function leads to growth inhibition. Q-RT-PCR and western blot of ES cells following ATF4 knockdown reveals down-regulation of PHGDH, PSAT1, and PSPH. In addition, ChIP-qPCR shows enrichment of ATF4 binding at SSP gene promoters, which is diminished by treatment with MI-503, a menin:MLL interaction inhibitor. Menin inhibition with MI-503 also leads to loss of ATF4 expression, coincident with loss of SSP expression. Additionally, ChIP-qPCR shows enrichment of menin binding at the ATF4 gene promoter, which is associated with H3K4me3 enrichment. Preliminary studies show that ATF4 over-expression via lentiviral transduction may rescue the loss of SSP gene expression induced by MI-503. Together these findings support the hypothesis that ATF4 acts downstream of menin to drive SSP activation in ES. Ongoing studies are assessing whether this is mediated by trithorax-dependent or –independent functions of menin. Citation Format: Jennifer Jimenez, Laurie K. Svoboda, Sudha Sud, Samuel Kerk, Jolanta Grembecka, Costas A. Lyssiotis, Elizabeth R. Lawlor. Menin and ATF4 cooperate to drive serine biosynthesis in Ewing sarcoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4356.
Terminological Teratology
Authors: J. H. AHRONHEIM
Journal: Annals of Internal Medicine (1971)

Letters, Comments, and Corrections1 November 1971Terminological TeratologyJ. H. AHRONHEIM, M.D.J. H. AHRONHEIM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-5-811_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Dr. Tashima's letter to the editor (ANNALS 75:323, 1971) in which he objected rightly to the term "penogram" in favor of the etymologically more correct term "phallogram," raises the issue of coining of medical terms in general, with particular reference to the combination of words of Latin and Greek origin.Knowledge of classical Greek, while fairly common among scientists in Europe, is a rarity in this country. The classics-conscious European physicians would always stress the importance of a correct medical term and strongly object to terms that did not conform to their ideas of etymological purity. As... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 569 Wildwood Ave. Jackson, Mich. 49201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1971Volume 75, Issue 5Page: 811-811KeywordsScientists Issue Published: 1 November 1971 PDF DownloadLoading ...
IS ROCKY MOUNTAIN FEVER PRESENT IN THE EASTERN UNITED STATES?
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Age related macular degeneration
Authors: U. Chakravarthy, J. Evans, P. J Rosenfeld
Journal: BMJ (2010)

The late stage manifestations of age related macular degeneration, neovascularisation and geographic atrophy, cause severe loss of central vision Standard care for neovascular age related macular degeneration is treatment with monoclonal antibodies that inhibit vascular endothelial growth factor.A fifth of those treated do not respond to treatment and a further quarter may lose the initial gains in visual acuity over time.No proven treatments exist for geographic atrophy.The preventive effects of supplementation with macular carotenoids (lutein/zeaxanthin) and omega3 fatty acids are under investigation.Age related macular degeneration, as the term implies, affects older adults and accounts for about half of all vision impairment or blind
433P High Beclin-1 expression predicts prolonged survival in locally advanced non-small cell lung cancer receiving docetaxel-platinum induction chemotherapy
Authors: H.Y. Lee, J.H. Shin, K-Y. Lee, J.K. Park, S.W. Sung, Y.S. Kim, J.H. Kang, J-O. Kim
Journal: Annals of Oncology (2016)