tbuckley/cabot-search huggingface dataset:
Encephalitis Associated with Rubella
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE CHALLENGE TO NEUROLOGY
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
First Conference on Radioprotectors and Anticarcinogens
Journal: JNCI Journal of the National Cancer Institute (1982)

Journal Article First Conference on Radioprotectors and Anticarcinogens Get access JNCI: Journal of the National Cancer Institute, Volume 68, Issue 3, March 1982, Page 536, https://doi.org/10.1093/jnci/68.3.536-a Published: 01 March 1982
The First Use of Penicillin in the United States
Authors: Charles M. Grossman
Journal: Annals of Internal Medicine (2009)

Letters19 May 2009The First Use of Penicillin in the United StatesCharles M. Grossman, MDCharles M. Grossman, MDFrom Legacy Good Samaritan Hospital, Portland, OR 97210.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-10-200905190-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I thank Dr. Ortiz, Dr. Waggoner, and Dr. Jackson for their comments (1–3) on my article (4) describing the first use of penicillin in the United States. Dr. Waggoner was correct: I missed an earlier report by Dawson and colleagues (5), who had used penicillin in the treatment of subacute bacterial endocarditis. The limited amounts available were too small to save any of the patients. Dr. Jackson quotes an article (6) on the use of penicillin on the patient in Yale-New Haven Hospital, which said, “The patient survived, married, and raised a family.” At the time, the patient ...References1. Ortiz AG. The first use of penicillin in the United States [Letter]. Ann Intern Med. 2009;150:145. [PMID: 19153418] LinkGoogle Scholar2. Waggoner JJ. The first use of penicillin in the United States [Letter]. Ann Intern Med. 2009;150:145-6. [PMID: 19153417] LinkGoogle Scholar3. Jackson EA. The first use of penicillin in the United States [Letter]. Ann Intern Med. 2009;150:146. [PMID: 19153421] LinkGoogle Scholar4. Grossman CM. The first use of penicillin in the United States. Ann Intern Med. 2008;149:135-6. [PMID: 18626052] LinkGoogle Scholar5. Dawson MH, Hobby GL, Meyer K, Chaffee E. Penicillin as a chemotherapeutic agent. J Clin Invest. 1941;20:434. Google Scholar6. Centers for Disease Control and Prevention (CDC). Achievements in public health, 1900–1999; control of infectious diseases. MMWR Morb Mortal Wkly Rep. 1999;48:621-9. [PMID: 10458535] MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Legacy Good Samaritan Hospital, Portland, OR 97210.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe First Use of Penicillin in the United States Charles M. Grossman The First Use of Penicillin in the United States Andres G. Ortiz The First Use of Penicillin in the United States Jesse J. Waggoner The First Use of Penicillin in the United States Eric A. Jackson Metrics Cited byIntroduction to wastewater microbiology: special emphasis on hospital wastewaterThe social value of candidate HIV cures: actualism versus possibilismIn Silico Approaches to Metabolic Engineering 19 May 2009Volume 150, Issue 10Page: 737KeywordsConflicts of interestEndocarditisHysterectomyPenicillinSports ePublished: 19 May 2009 Issue Published: 19 May 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Effectiveness of abiraterone as salvage therapy in patients with docetaxel- and castration-resistant prostate cancer (mDCPC) that progressed during second-line chemotherapy with carboplatin plus weekly docetaxel (DC).
Authors: Christoph W. Reuter, Michael A. Morgan, Martin Fenner, Viktor Grünwald, Arnold Ganser
Journal: Journal of Clinical Oncology (2013)

162 Background: Our recent data have shown that carboplatin AUC5 on d1 plus docetaxel at a dose of 35 mg/m2 iv on d1, 8, 15 every 4 weeks (q4w) is an effective salvage therapy in mDRPC. Patients (pts) who have progressive disease during DC treatment survive only ~7 months and many are symptomatic. We have demonstrated that high free testosterone (FT) serum levels during DC treatment have a negative prognostic value for PSA response and overall survival in these pts. In this study the impact of abiraterone treatment and other subsequent salvage regimens after DC failure was analyzed. Methods: DC failure was defined as disease progression during DC treatment according to the Prostate Cancer Working Group (PCWG2 2007) criteria. Since February 2005, 74 consecutive DRPC pts were treated with at least 2 cycles DC until disease progression. At the time of the current analysis 67 pts have progressed and 41 pts received one or more subsequent therapies (1-3). Results: Overall survival (OS) of all 67 pts who have progressed during DC treatment was 7.1 months (CI 95% 1.8, 12.3). 41 pts received subsequent salvage therapies including mitoxantrone-prednisone-etoposide (MPE) (n=10), cabazitaxel (n=10), docetaxel-oxaliplatin (n=8), abiraterone (n=15) and doxorubicin-ketokonazol (n=5). OS of these 41 pts was 14.6 months (CI 95% 11.0, 18.3).In pts receiving abiraterone as salvage treatment, OS after DC was 21.8 months (CI 95% 7.2, 36.5) versus 11.9 months (CI 95% 9.0, 14.8) in pts receiving other regimens (HR 0.302, CI 95% 0.11, 0.8; p=0.016). Responses of prostate-specific antigen (PSAR; ≥30% and ≥50%) were only observed in pts receiving abiraterone (8/15, 53.3% and 4/15, 26.7%, respectively). Conclusions: Our data demonstrate for the first time that testosterone is an important prognostic factor for PSA response and OS in mDRPC patients receiving DC chemotherapy and that targeting testosterone after DC failure prolongs post-DC survival.
Quantitative electroencephalography: a report on the present state of computerized EEG techniques. American Psychiatric Association Task Force on Quantitative Electrophysiological Assessment
Journal: American Journal of Psychiatry (1991)

The American Psychiatric Association established the Task Force on Quantitative Electrophysiological Assessment in May 1989 to consider several questions of interest to psychiatrists. From the inception of techniques for quantitative electroencephalography (qEEG), the possibility was raised that it would substantially assist in the diagnosis of brain disorders. However, controversy exists over the scientific basis for such approaches and the training necessary for interpretation of computerized records. The task force's charge was to report 1) the present state of scientific knowledge about qEEG, 2) the role of qEEG in clinical psychiatric practice at the present time, 3) the training necessary for the use of qEEG techniques, and 4) the possible future of the technique in the study of mental disorders. The task force concluded that qEEG is particularly useful for the detection of abnormalities in slow waves, which are a feature of delirium, dementia, intoxication, and other syndromes involving gross CNS dysfunction. The ability of qEEG to help in the diagnosis of other disorders, such as schizophrenia or depression, is not yet established. Clinical replications and sharing of normative and patient data bases are necessary for the advancement of this field. Proper use of this technique requires extensive training in a center experienced in its use. Standards for training and for using the technology in psychiatry are urgently needed. This report was approved by the Board of Trustees in December 1990.
Chromosome Synthesis&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Aya, Takao, Sandberg, Avery A.
Journal: JNCI Journal of the National Cancer Institute (1971)

Journal Article Chromosome Synthesis Get access Takao Aya, Takao Aya Roswell Park Memorial Institute, Buffalo, New York 14203 Search for other works by this author on: Oxford Academic PubMed Google Scholar Avery A. Sandberg Avery A. Sandberg Roswell Park Memorial Institute, Buffalo, New York 14203 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 47, Issue 5, November 1971, Pages 961–971, https://doi.org/10.1093/jnci/47.5.961 Published: 01 November 1971 Article history Received: 08 September 1970 Revision received: 26 April 1971 Accepted: 14 July 1971 Published: 01 November 1971
B-TYPE NATRIURETIC PEPTIDE DURING TREATMENT WITH SACUBITRIL/VALSARTAN: THE PARADIGM-HF TRIAL
Authors: Muthiah Vaduganathan, Peder Myhre, Brian Claggett, Milton Packer, Akshay S. Desai, Jean L. Rouleau, Michael R. Zile, Karl Swedberg, Martin Lefkowitz, Victor Shi, John J.V. McMurray, Scott D. Solomon
Journal: Journal of the American College of Cardiology (2019)
Neoplasia and cell/molecular biology free papers 124-139
Authors: S Parry, J Barton, M Welfare, I Mohammed, L Cherkas, S Riley, T Spector, N Trudgill, S Lal, J Mclaughlin, G Giampaolo, G Dockray, A Varro, D Thompson, J Jones, D Kendall, P Millns, C Hawkey, S Dunlop, D Jenkins, R Spiller, L Gregory, L Yaguez, S Coen, E Amaro, S Smale, A Hobson, S Williams, Q Aziz, V Chudleigh, E Brennan, S Tarry, S Myers, S Lewis, G Smith, K Palmer
Journal: Gut (2002)

Introduction: Previous studies, many uncontrolled, suggest 4 to 32% of people develop irritable bowel syndrome (IBS) after ID.Little information is available on the development of other FGIDs after ID.Aim: To determine if patients with stool culture confirmed bacterial diarrhoea were more likely to develop gut symptoms consistent with a diagnosis of IBS, functional dyspepsia or functional diarrhoea at 3 and 6 month follow up compared with community controls.Methods: A prospective community-based case-control study over one year.Subjects with stool positive bacterial infectious diarrhoea and control subjects from the same primary care practice were invited to participate.The presence or not of IBS, functional dyspepsia or functional diarrhoea was diagnosed at the start and at follow up using self-complete Rome II modular questionnaires.The diagnosis of a baseline FGID excluded subjects from continuing.There were 128 cases and 219 community controls eligible and who consented to participate.Results: At follow up there was a higher incidence of FGIDs in the cases compared with controls, mainly due to a higher incidence of IBS (see table ).There was no difference in the incidence of functional dyspepsia between cases and controls.Conclusions: IBS and functional diarrhoea is diagnosed more frequently in people at three and six-month follow up after an episode of stool positive bacterial diarrhoea compared with community controls despite careful exclusion of people with pre-existing FGIDS and adds further support for the concept of post-infectious IBS.
Melanoma
Authors: Daniel G. Coit, Robert Andtbacka, Christopher K. Bichakjian, Raza A. Dilawari, Dominick DiMaio, Valerie Guild, Allan C. Halpern, F. Stephen Hodi, Mohammed Kashani-Sabet, Julie R. Lange, Anne Lind, Lainie Martin, Mary C. Martini, Scott K. Pruitt, Merrick I. Ross, Stephen F. Sener, Susan M. Swetter, Kenneth K. Tanabe, John A. Thompson, Vijay Trisal, Marshall M. Urist, Jeffrey Weber, Michael K. Wong
Journal: Journal of the National Comprehensive Cancer Network (2009)

In 2008, an estimated 62,480 new cases of melanoma will have been diagnosed and approximately 8420 patients will have died of the disease in the United States. 1 However, these projections for new cases may represent a substantial underestimation, because many superficial and in situ melanomas treated in the outpatient setting are not reported.The incidence of melanoma continues to increase dramatically.Melanoma is increasing in men more rapidly than any other malignancy and more rapidly in women than any other malignancy except lung cancer.For someone born in the United States in 2005, the lifetime risk for developing melanoma may be as high as 1 in 55. 2 Melanoma ranks second to adult leukemia in terms of loss of years of potential life, per death.The median age at diagnosis is 59 years.
From the authors
Authors: C. G. Cote
Journal: European Respiratory Journal (2007)

Present data indicate that for patients receiving erythropoietic agents, target haemoglobin levels should be 11-12 g?dL -1 [6], and, in the study by COTE et al. [1], haemoglobin ,13 g?dL -1 was the cut-off level to define anaemia.Overcorrection of anaemia to normal haemoglobin levels [7] and insufficient treatment [8] have each been associated with unfavourable clinical courses.This elegant study by COTE et al. [1] has opened a new debate on ideal targeted haemoglobin levels in chronic stable chronic obstructive pulmonary disease patients.
WHISKY—THEN AND NOW
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Veillonella as a bile acid-sensitive bacteria and a microbiome-based biomarker for aldafermin (NGM282) in patients with non-alcoholic steatohepatitis
Authors: Rohit Loomba, Lei Ling, Duy Dinh, Bryan Baxter, Alex DePaoli, Hsiao Lieu, Stephen Harrison, Arun Sanyal
Journal: Journal of Hepatology (2020)
Adjuvant chemoradiotherapy for T3, T4, or node positive gastric cancer: A phase II trial
Authors: V. B. Sharma, A. C. Koong, C. Cho, V. K. Mehta, M. C. Chen, J. A. Bastidas, W. Trueblood, G. A. Fisher, J. M. Ford
Journal: Journal of Clinical Oncology (2004)

4139 Background: Postoperative chemoradiotherapy using bolus 5FU has recently been established as the standard treatment of Stage II/III gastric cancer (Macdonald et. al., NEJM, 2001). Here we report the preliminary results of a modified "Macdonald" regimen, incorporating carboplatin and utilizing the less toxic infusional 5FU regimen, in the adjuvant treatment for resected T3/T4 or node positive gastric cancer. Methods: 19 patients underwent complete en bloc surgical resection and were treated with postoperative chemoradiotherapy for a total of 19 weeks. They received 5FU (200 mg/m2/day) via continuous IV infusion for weeks 1–6; leucovorin (20 mg/m2) on days 1, 8, 15, 22, 29, 36; and carboplatin (AUC 6) on days 1 and 22. This was followed by a one-week rest period. On week 8, patients were re-started on infusional 5FU (200mg/m2/day) with daily radiotherapy administered with standard AP/PA fields to a total dose of 4500 cGy. One to two weeks after completion of their radiation, patients then received an additional six weeks of chemotherapy identical to the first six weeks as tolerated. Results: The overall and disease free survival for combined postoperative chemoradiotherapy was 58% (95% CI 37%–79%). Survival by stage was 80% (95% CI 63%–97%) for stage II (4 out of 5 patients alive); 70% (95% CI 50%–90%) for stage IIIA/IIIB (7 out of 10 patients alive); and 0% for stage IV disease (T3N3M0; 0 out of 4 patients alive). 5 patients died from recurrent disease (26%), 2 died from other (non-malignant) causes (10%), and one was lost to follow-up. Median follow-up was 19 months (range 6 to 72 months) and median survival has not yet been reached. The most common toxicity was neutropenia (29% grade 3, 6% Grade 2); thrombocytopenia (12% grade 3, 18% grade 2); anemia (29% grade 2); and stomatitis (12% grade 2, 18% grade 1). Conclusion: In patients with advanced gastric cancer (T3/T4 or node positive disease) the addition of adjuvant chemoradiotherapy improves overall survival when compared to surgery alone. This regimen of continuous infusion 5FU/leucovorin/carboplatin and radiotherapy was relatively well tolerated with an overall survival of 58% and a median survival that has not been reached. No significant financial relationships to disclose.
Native American Veterans
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Status of anesthesiology, 1965. Be neither apologetic nor submissive
Authors: K. K. Keown
Journal: JAMA (1966)

Anesthesiology is a distinct medical discipline. It has long been classified by the American Medical Association as the practice of medicine. A description of the subject matter and the professional responsibilities of anesthesiology would encompass at least the following: (1) the rendition of a state of insensibility to pain during surgical, obstetrical, and dental intervention, (2) the support of life's function under the stress of anesthesia and surgery, (3) the management of the patient unconscious from whatever cause, (4) the teaching and management of respiratory and cardiac resuscitation, and (5) the supervision of and instruction in inhalation therapy departments. Prior to the inauguration of anesthesia, the omnipresence of pain and discomfort decreased the will of the sufferer to live. Great surgical procedures were planned and carried out on cadavers, but not in the clinics, a fact often overlooked by contemporary surgeons or, perhaps even worse, never realized. Therefore, most of
Autoantibody formation against a 190-kDa antigen of the desmosomal plaque in pemphigus foliaceus
Authors: R. GHOHESTANI, P. JOLY, D. GILBERT, J.F. NICOLAS, E. THOMINE, E. COZZANI, PH. LAURET, A. CLAUDY, F. TRON
Journal: British Journal of Dermatology (1997)
Le phosphore: Techniques chimiques, physiologie, pathologie, thérapeutique
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phlegmasia cerulea dolens. Case report with notes on a new treatment
Authors: L. Pelner
Journal: JAMA (1966)

PHLEGMASIA cerulea dolens, aptly termed "gangrene of venous origin," is a relatively infrequent condition, only 200 cases having been described up to the present time.<sup>1</sup>It is the most severe form of venous thrombotic disease. The extreme gravity of this disease can be deduced from the frequent development of shock, gangrene, and pulmonary embolism, often resulting in death. In a recent survey of the literature, it was found that 31.9% of the patients died, gangrene developed in 31.9% of the survivors, and 41.6% of those who recovered had post-thrombotic syndrome.<sup>2</sup>The post-thrombotic syndrome consisted of pain and swelling of the involved limb on standing for a prolonged period. We used a form of treatment, intravenously administered dextran 75, which we believe has not been previously reported as a treatment of this disease. The improvement was so prompt and decisive, that we believe it should be tried before more