tbuckley/cabot-search huggingface dataset:
The Application of Synthetic hANP in Diabetic Nephropathy With Nephrotic Syndrome
Authors: Y. Kikumoto
Journal: Diabetes Care (2006)

group was restricted to normoglycemic individuals Ͼ60 years of age to minimize inclusion of those likely to develop type 2 diabetes later in life.In addition, P12A genotyping was also performed on a random sample of 727 Saudi neonatal bloodspots to ascertain P12A allele frequencies in an unbiased sample.Data analysis was first performed for an age-and sex-matched cohort in which the type 2 diabetic cases (n ϭ 118) and control subjects (n ϭ 219) were Ͼ60 years old.The male-to-female ratios of these case and control subjects were 1.40 and 1.43, respectively.The P, or risk allele, frequency was 0.974 and 0.968 in type 2 diabetic and control subjects, respectively, and was not statistically significant (P ϭ 0.633).However, given the very high incidence of the P allele in this population, the study size was extremely underpowered.No age-related differences in P12A allele frequencies were observed.Demonstration of statistical significance or lack thereof in the Saudi population, at a 95% CI or better, is impractical, as this would require case and c o n t r o l p o p u l a t i o n s w h e r e n i s Ͼ175,000.The high incidence of the P allele in the Saudi population was confirmed by the neonatal sample set in which frequency of this allele was found to be 0.957.
Surgery
Authors: C. H. Organ
Journal: JAMA (1992)

The impact of molecular biology during 1991 has attained increased importance in the understanding of processes affecting and caused by surgical procedures. Unresectable tumors and the inability of the body to cope with diseased tissues that continue to perform normal functions still require extirpation. Prevention of complications induced by surgical intervention, such as postoperative infection, is beginning to be understood. Parekh et al<sup>1</sup>reported in experimental animals that FOY-305, which stimulates the release of endogenous cholecystokinin, caused both hypertrophy and hyperplasia of pancreatic remnants following distal pancreatectomy. If this can be duplicated in humans, it could have significant implications for patients undergoing pancreatectomy or in patients with pancreatic exocrine insufficiency. Cheadle et al<sup>2</sup>confirmed that peripheral blood monocytes HLA-DR are a reliable marker for clinically significant surgical infections. Clarification of the deficits associated with this marker may open up new methods of prophylaxis and treatment for surgically related
Protecting and informing human research subjects
Authors: W. A. Check
Journal: JAMA (1980)

Most physicians in private practice will never encounter an Institutional Review Board (IRB) and probably have only a vague notion of what such an entity does. Yet IRBs—which review human research proposals at medical schools and large hospitals to ensure that subjects' rights are protected—can be instrumental in expanding or limiting the office practitioner's future therapeutic arsenal, asserts Sanford Chodosh, MD. "The therapies of today are based on the research of five to ten years ago," points out Chodosh, a clinical investigator at Boston University School of Medicine and chairman of the IRB at Boston City Hospital. Following revelations several years ago that a few investigators had disregarded subjects' rights, "a real threat to development of new therapies emerged in the form of [government] regulation that inhibits some clinical research," he adds. <i>continued on next page continued from previous page</i> In this climate, "the IRB has the responsibility for promoting
THE OLD CONGRESS PASSES, THE NEW BEGINS
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tuberculous pericarditis
Authors: D H Spodick
Journal: BMJ (1994)

Tuberculous pericarditis ED1TOR,-The case of tuberculous pericarditis presented by C P Clifford and G J Davies' contained a misleading characterisation of the findings on admission as classic tamponade.Kuss- maul's sign and an abnormal third heart sound are inconsistent with the physiology of classic tamponade.'Indeed, it is the virtual elimination of the rapid filling period necessary to produce a third heart sound that is a classic feature of tamponade.It is far more likely that this patient already had, under the tamponading fluid, an epicardial con- striction with its typically mixed picture; a pulsus paradoxus with a 20 mm Hg fall in blood pressure is unusual while a third heart sound and Kussmaul's sign are the rule in constriction.2Although acute tuberculous pericarditis can progress rapidly to acute or subacute constriction, this was not such a case.34Finally, I wish to argue against the term "peri- cardial knock."The abnormal early diastolic sound of constrictive pericarditis does not usually present an auscultatory knocking quality.More importantly, this description clouds concepts even if this form of the third heart sound did always "knock."The early diastolic sound of constrictive pericarditis is an especially early and often loud third heart sound with all necessary abnormal dynamics-accelerated early ventricular filling, with abrupt deceleration, into ventricles made abnormally stiffby pericardial scarring.'
First-in-human study of MM-141: A novel tetravalent monoclonal antibody targeting IGF-1R and ErbB3.
Authors: Steven J. Isakoff, Mansoor N. Saleh, Alexey Lugovskoy, Sara Manoli, Akos Gabor Czibere, Patricia LoRusso, Monica Arnedos
Journal: Journal of Clinical Oncology (2014)

3068^ Background: MM-141 is a novel tetravalent bi-specific monoclonal antibody that binds IGF-1R and ErbB3, and blocks both ligand dependent and independent IGF-1R/ErbB3/PI3K/AKT/mTOR signaling. In preclinical xenograft models, MM-141 was more active than a combination of anti-ErbB3 and anti-IGF-1R monoclonal antibodies. MM-141 potentiated the activity of gemcitabine, paclitaxel, docetaxel, tamoxifen, and everolimus. These results support the clinical development of MM-141 and a multi-arm Phase 1 study is underway. The completed monotherapy arm of this trial will be reported Methods: This is a Phase 1 dose-escalation study evaluating safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) properties of MM-141 as monotherapy (Arm A, n=15) and in combination with everolimus (Arm B) or with nab-paclitaxel and gemcitabine (Arm C). Patients in Arm A were dosed in a “3+3” design at weekly doses of 6 mg/kg (n=3), 12 mg/kg (n=4), or 20 mg/kg (n=4), or at biweekly doses of 40 mg/kg (n=4). Doses were escalated until the maximum tolerated dose (MTD) was identified, or until MM-141 was shown to be tolerable at the highest planned dose. Results: Arm A enrolled 15 patients with advanced solid tumors into the dose escalation portion of the study. No dose-limiting toxicities were observed at weekly dose levels of 6mg/kg, 12mg/kg, and 20mg/kg, or at the biweekly dose of 40mg/kg. Adverse events, regardless of relationship, that were reported with a frequency >15% included: vomiting (7/15), nausea (6/15), fatigue (4/15), abdominal pain (4/15), increased AP (4/15), dyspnea (4/15), diarrhea (3/15), anemia (3/15), increased AST (3/15), and rash (3/15). The safety, tolerability, PK and PD profile support weekly and biweekly MM-141 dosing. Detailed PK and PD data will be presented for all cohorts. Disease stabilization was observed in patients with Ewing’s Sarcoma (1) and parotid gland carcinoma (1). An expansion cohort at a weekly dose of 20mg/kg (Arm D) is ongoing in patients with hepatocellular carcinoma. Data summarized here are from a data lock at 01/15/2014. Conclusions: A recommended dose level for MM-141 on each of weekly and bi-weekly schedules was established. Clinical trial information: NCT01733004.
Bone Scans
Authors: Charles K. Tashima
Journal: JAMA (1977)

<h3>To the Editor. —</h3> I wish to extend the arguments of Chayes and Meyer (238: 305-306, 1977) concerning the usefulness of bone scans in cancer patients by suggesting that the clinical implications of bone scans have yet to be exhausted. Recent reports indicate that positive bone scans may be helpful in determining prognosis in breast cancer.<sup>1,2</sup>Bone scans can aid in the detection of other conditions besides osseous metastases, such as pulmonary calcification,<sup>3</sup>soft tissue metastases,<sup>4</sup>pulmonary osteoarthropathy,<sup>5</sup>and other conditions<sup>6,7</sup> Bone scans may be used to assess the response of metastatic disease to treatment.<sup>8</sup>While the condition of positive bone scan, negative roentgenograms, and lack of confirmation with bone biopsy may not always indicate osseous metastases, we have encountered patients whose bone scans reverted to normal as other measurable metastatic disease responded to systemic therapy. Further difficulties with the asymptomatic bone metastases have
Leads from the MMWR. National Childhood Vaccine Injury Act: requirements for permanent vaccination records and for reporting of selected events after vaccination
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ADDISON'S DISEASE AND TUBERCULOSIS OF THE SUPRARENAL GLANDS
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sterility and Impaired Fertility
Authors: M. Barton, F. J. Browne, R. Christie-Brown, G. Dodds, G. Graff, A. Green, V. B. Green-Armytage, C. Harvey, M. H. Jackson, R. W. Johnstone, W. C. W. Nixon, C. Lane-Roberts, A. Sharman, M. M. White, B. P. Wiesner, K. Walker
Journal: BMJ (1943)

<h3>Abstract</h3> The balance between nutrition and energy needs has an important impact on the spatial distribution of foraging animals. In the present paper, we focus on the case of bumble bees moving around a landscape in search of pollen (to meet nutritional needs) and nectar (to meet energy needs). Depending on the colony demands, bumble bees can concentrate their foraging effort towards either pollen rich flower species or nectar rich flower species. This behaviour allows us to establish a strategy – a spatial landscape design – which can maximize the pollination services of crops that are nutritionally deficient for pollinators by adding nutritionally rich wildflower patches. To do this, we formulate a mathematical partial integro-differential equation model to predict the spatial distribution of foraging bumble bees. We use our model to predict the location, composition and quantity of the wildflower patches adjacent to crop fields that will be most beneficial for crop pollination services. Our results show that relatively small quantities of wildflowers in specific locations with respect to the nest sites and the crop can have a positive impact on pollination services when the composition (i.e., pollen to nectar ratio) of the added wildflowers is significantly different from the composition of the existing crop flowers.
Excessive damages
Authors: A. R. Holder
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elevated intracranial pressure and computed tomography of the brain in fulminant hepatocellular failure
Authors: S Muñoz
Journal: Hepatology (1991)

Cerebral herniation is a leading cause of death in patients with fulminant hepatocellular failure. Classical signs of elevated intracranial pressure are often absent in these patients. A reliable noninvasive method by which the presence of cerebral edema could be determined is much needed. To assess the efficacy of computed tomography of the brain in this setting, we compared the radiographic findings to the intracranial pressure measured by an epidural monitor in patients with fulminant hepatic failure. Unfortunately, a considerable difference existed between the presence of cerebral edema diagnosed by computed tomography of the brain and elevation of the intracranial pressure. Our observations suggest that in patients with fulminant hepatic failure and advanced hepatic encephalopathy, computed tomography of the brain is of little value in detecting cerebral edema. Pressure monitoring is most important to establish the presence and guide the therapy of intracranial hypertension. (HEPATOLOGY 1991;13:209–212).
Pigmented gut.
Journal: BMJ (1968)

Detailed information on the chemical composition of the body remains for the most part tantalizingly out of reach.Direct chemical analysis of normal adult cadavers is restrained by formidable difficulties and has seldom been achieved.Indirect methods, including balance studies and dilution tech- niques (with radioactive or stable tracers), give information, but we still have no reliable way of estimating, for example, the total amount of sodium or calcium in the body.The method of activation analysis has many applications in biology and medicine.' 2 In a novel use recently reported by G. W.
Surgery of the liver and biliary tract. Ed 2 Edited by L. H. Blumgart, 2,902 pp. New York: Churchill Livingstone, 1994. $350
Authors: R ROSSI
Journal: Hepatology (1995)

<dm:abstracts xmlns:dm="http://www.elsevier.com/xml/dm/dtd"><ce:abstract xmlns:ce="http://www.elsevier.com/xml/common/dtd" class="author" xml:lang="en" id="ab005" view="all"><ce:section-title id="st005">Abstract</ce:section-title><ce:abstract-sec id="as005" view="all"><ce:simple-para id="sp0005" view="all">The frequency of HBV-reactivation in patients with previous HBV infection during DAA therapy has been not clarified. In present study, we found that 5.7% (5/87) of patients with previous HBV infection had experienced HBV-reactivation (n=1) or showed detectable HBV-DNA (n=4) during IFN-free DAA treatment.</ce:simple-para></ce:abstract-sec><ce:abstract-sec id="as010" view="all"><ce:section-title id="st010">Clinical trial number</ce:section-title><ce:simple-para id="sp0010" view="all">UMIN000023366</ce:simple-para></ce:abstract-sec></ce:abstract></dm:abstracts>
CHOLANGIOLITIC BILIARY CIRRHOSIS
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 771: CMTM6-mediated maintenance of sarcoma malignancy
Authors: Yuko Nishiyama, Naoto Tsuchiya
Journal: Cancer Research (2019)

Abstract Sarcomas are malignant bone and soft tissue tumors that have highly aggressive and metastatic features. To reveal molecular networks associated with sarcomas, comprehensive expression profiles were generated using clinical samples. We identified miR-451a, showing different levels according to the prognosis of Ewing’s sarcoma (EWS) patients. High expression of miR-451a was also associated with good prognoses of patients with other types of sarcomas, suggesting repression of malignant properties across histological subtypes. Although miR-451a did not affect cell proliferation, it strongly repressed migration of EWS cells. Using gene expression analysis, we identified that CMTM6, encoding a chemokine-like membrane protein, was a target of miR-451a. Depletion of CMTM6 suppressed cell migration and induced changes in the expression of genes encoding plasma membrane and secretory proteins. Interestingly, we found high levels of CMTM6 mRNA under low-glucose culture conditions. Unexpectedly, under the same conditions, high extracellular miR-451a levels were observed; this suggested that the glucose level might be a modulator of the miR-451a-CMTM6 axis. Our data suggest that the malignant properties of sarcoma are influenced by the nutrient status of the tumor microenvironment. Citation Format: Yuko Nishiyama, Naoto Tsuchiya. CMTM6-mediated maintenance of sarcoma malignancy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 771.
Effect of Interval between Neutron Radiation and Diethylstilbestrol on Mammary Carcinogenesis in Female ACI Rats
Authors: Claire J. Shellabarger, J. Patrick Stone, Seymour Holtzman
Journal: Environmental Health Perspectives (1983)

Both radiation and diethylstilbestrol (DES) are carcinogens for the mammary gland of ACI female rats. When DES is given at about the same time as radiation, DES and radiation interact in a synergistic fashion particularly in regard to the number of mammary adenocarcinomas per rat. We have studied the effect of increasing the time interval between radiation and DES on the capacity of DES to enhance (promote?) radiation-induced mammary carcinogenesis. DES, in the form of a compressed pellet containing a mixture of cholesterol and DES, formulated to average 1.25 mg of DES/100 gr body weight, was given to groups of approximately 28 rats at 2 days before, or 50, 100 or 200 days after 0.064 Gy of 0.43 MeV neutron radiation. At each time that DES was given to irradiated rats, DES was also given to nonirradiated rats. All rats were studied for 375 days after the date of the DES administration. When the total number of mammary adenocarcinomas was calculated as a percentage of 24 sites per rat at-risk, DES and radiation always produced a response that was larger than the sum of the responses of DES alone plus radiation alone. This result suggests that these two agents can interact in a synergistic fashion. The interaction between radiation and DES did not decline as the time interval between radiation and DES was lengthened. This result suggests that radiation-induced (initiated?) mammary carcinogenesis is not subject to repair since DES enhancement (promotion?) continues to be effective over long time intervals.