tbuckley/cabot-search huggingface dataset:
Nearly 500 000 in UK May Have Missed Blood Pressure Drugs
Authors: Howard Larkin
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dynamic network modeling of gut microbiota during Alzheimer’s disease progression in mice
Authors: Yinhu Li, Yijing Chen, Yingying Fan, Yuewen Chen, Yu Chen
Journal: Gut Microbes (2023)

The intimate association between the gut microbiota (GM) and the central nervous system points to potential intervention strategies for neurological diseases. Nevertheless, there is currently no theoretical framework for selecting the window period and target bacteria for GM interventions owing to the complexity of the gut microecosystem. In this study, we constructed a complex network-based modeling approach to evaluate the topological features of the GM and infer the window period and bacterial candidates for GM interventions. We used Alzheimer's disease (AD) as an example and traced the GM dynamic changes in AD and wild-type mice at one, two, three, six, and nine months of age. The results revealed alterations of the topological features of the GM from a scale-free network into a random network during AD progression, indicating severe GM disequilibrium at the late stage of AD. Through stability and vulnerability assessments of the GM networks, we identified the third month after birth as the optimal window period for GM interventions in AD mice. Further computational simulations and robustness evaluations determined that the hub bacteria were potential candidates for GM interventions. Moreover, our GM functional analysis suggested that Lachnospiraceae UCG-001 – the hub and enriched bacterium in AD mice – was the keystone bacterium for GM interventions owing to its contributions to quinolinic acid synthesis. In conclusion, this study established a complex network-based modeling approach as a practical strategy for disease interventions from the perspective of the gut microecosystem.
Changes in Pregnancy-Associated Deaths in the US During the COVID-19 Pandemic in 2020
Authors: Claire E. Margerison, Xueshi Wang, Alison Gemmill, Sidra Goldman-Mellor
Journal: JAMA Network Open (2023)

This cross-sectional study assesses changes in pregnancy-associated mortality from drug overdose, homicide, suicide, and other causes in the US from 2018 through 2020.
Increased 18F-PSMA and 18F-FDG Uptake in Lipomatous Hypertrophy of the Interatrial Septum
Authors: Hannes Grünig, Klaus Strobel, Andrea Zander, Maria del Sol Pérez Lago
Journal: Clinical Nuclear Medicine (2023)

Abstract Lipomatous hypertrophy of the interatrial septum (LHIS) is a benign anomaly with low prevalence. Lipomatous hypertrophy of the interatrial septum is asymptomatic in most of the cases and rarely leads to atrial arrhythmias, obstructive flow symptoms, or sudden death. It is mostly diagnosed as an incidental finding in cross-sectional imaging and echocardiography, and increased 18 F-FDG uptake on LHIS has been described. We present a case of repeated increased 18 F-PSMA uptake in LHIS. Although very rare, familiarity with the typical features and prevalence of LHIS in PET/CT can avoid misinterpretation for metastatic disease.
Permanent section margin concordance after Mohs micrographic surgery with immunohistochemistry for invasive melanoma and melanoma in situ: A retrospective dual-center analysis
Authors: Jade N. Young, Tuyet A. Nguyen, S. Caleb Freeman, Emma Hill, Mariah Johnson, Nima Gharavi, Anna Bar, Justin Leitenberger
Journal: Journal of the American Academy of Dermatology (2023)
Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells
Authors: Faruk Sacirbegovic, Matthias Günther, Alessandro Greco, Daqiang Zhao, Xi Wang, Meng Zhou, Sarah Rosenberger, Martin H. Oberbarnscheidt, Werner Held, Jennifer McNiff, Dhanpat Jain, Thomas Höfer, Warren D. Shlomchik
Journal: Immunity (2023)
Multisized Photoannealable Microgels Regulate Cell Spreading, Aggregation, and Macrophage Phenotype through Microporous Void Space
Authors: Jeremy M. Lowen, Gabriella C. Bond, Katherine H. Griffin, Nathan K. Shimamoto, Victoria L. Thai, J. Kent Leach
Journal: Advanced Healthcare Materials (2023)

Microgels are an emerging platform for in vitro models and guiding cell fate due to their inherent porosity and tunability. This work describes a light-based technique for rapidly annealing microgels across a range of diameters. Utilizing 8-arm poly(ethylene) glycol-vinyl sulfone, the number of arms available for crosslinking, functionalization, and annealing is stoichiometrically controlled. Small and large microgels are fabricated to explore how microgel diameter impacts void space and the role of porosity on cell spreading, cell aggregation, and macrophage polarization. Mesenchymal stromal cells spread rapidly in both formulations, yet the smaller microgels permit a higher cell density. When seeded with macrophages, the smaller microgels promote an M1 phenotype, while larger microgels promote an M2 phenotype. As another application, the inherent porosity of annealed microgels is leveraged to induce cell aggregation. Finally, the microgels are implanted to examine how different size microgels influence endogenous cell invasion and macrophage polarization. The use of ultraviolet light allows for microgels to be noninvasively injected into a desired mold or wound defect before annealing, and microgels of different properties combined to create a heterogeneous scaffold. This approach is clinically relevant given its tunability and fast annealing time.
An expedited strategy for accurate and timely integrated molecular diagnosis of gliomas
Authors: Timothy A Gregory, Garret L Williford, Jacob M Maronge, Kristin Alfaro, Gregory N Fuller, John de Groot, Vinay K Puduvalli, Leomar Y Ballester, Nazanin K Majd
Journal: Neuro-Oncology (2023)

Journal Article An expedited strategy for accurate and timely integrated molecular diagnosis of gliomas Get access Timothy A Gregory, Timothy A Gregory Department of Neuro-Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Garret L Williford, Garret L Williford Department of Neuro-Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Jacob M Maronge, Jacob M Maronge Department of Biostatistics, University of Texas, MD Anderson Cancer Center, Houston, TX, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Kristin Alfaro, Kristin Alfaro Department of Neuro-Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Gregory N Fuller, Gregory N Fuller Department of Neuropathology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar John de Groot, John de Groot Department of Neuro-Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Vinay K Puduvalli, Vinay K Puduvalli Department of Neuro-Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA https://orcid.org/0000-0001-8396-9500 Search for other works by this author on: Oxford Academic PubMed Google Scholar Leomar Y Ballester, Leomar Y Ballester Department of Neuropathology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA https://orcid.org/0000-0002-6854-6830 Search for other works by this author on: Oxford Academic PubMed Google Scholar Nazanin K Majd Nazanin K Majd Department of Neuro-Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA Corresponding Author: Nazanin K. Majd, MD, 1400 Holcombe Blvd, Houston, TX 77030, USA (NKMajd@mdanderson.org) Search for other works by this author on: Oxford Academic PubMed Google Scholar Neuro-Oncology, Volume 25, Issue 4, April 2023, Pages 808–809, https://doi.org/10.1093/neuonc/noad007 Published: 01 February 2023
Racial Disparities in Adversity During Childhood and the False Appearance of Race-Related Differences in Brain Structure
Authors: Nathalie M. Dumornay, Lauren A.M. Lebois, Kerry J. Ressler, Nathaniel G. Harnett
Journal: American Journal of Psychiatry (2023)

Objective: Black Americans in the United States are disproportionately exposed to childhood adversity compared with White Americans. Such disparities may contribute to race-related differences in brain structures involved in regulating the emotional response to stress, such as the amygdala, hippocampus, and prefrontal cortex (PFC). The authors investigated neuroanatomical consequences of racial disparities in adversity. Methods: The sample included 7,350 White American and 1,786 Black American children (ages 9–10) from the Adolescent Brain Cognitive Development Study (public data release 2.0). Structural MRI data, parent and child self-reports of adversity-related measures, and U.S. Census neighborhood data were used to investigate the relationship between racial disparities in adversity exposure and race-related differences in brain structure. Results: Black children experienced more traumatic events, family conflict, and material hardship on average compared with White children, and their parents or caregivers had lower educational attainment, lower income, and more unemployment compared with those of White children. Black children showed lower amygdala, hippocampus, and PFC gray matter volumes compared with White children. The volumes of the PFC and amygdala, but not the hippocampus, also varied with metrics of childhood adversity, with income being the most common predictor of brain volume differences. Accounting for differences in childhood adversity attenuated the magnitude of some race-related differences in gray matter volume. Conclusions: The results suggest that disparities in childhood adversity contribute to race-related differences in gray matter volume in key brain regions associated with threat-related processes. Structural alterations of these regions are linked to cognitive-affective dysfunction observed in disorders such as posttraumatic stress disorder. More granular assessments of structural inequities across racial/ethnic identities are needed for a thorough understanding of their impact on the brain. Together, the present findings may provide insight into potential systemic contributors to disparate rates of psychiatric disease among Black and White individuals in the United States.
Supervision and Transparency in Resident Training
Authors: Kyla Terhune
Journal: JAMA Surgery (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Prehospital Needle Decompression Should Not Be Compared With Trauma Center Chest Tube Placement—Reply
Authors: Daniel Muchnok, Francis X. Guyette, Joshua B. Brown
Journal: JAMA Surgery (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Association of Rare Protein-Truncating DNA Variants in <i>APOB</i> or <i>PCSK9</i> With Low-density Lipoprotein Cholesterol Level and Risk of Coronary Heart Disease
Authors: Jacqueline S. Dron, Aniruddh P. Patel, Yiyi Zhang, Sean J. Jurgens, Dimitri J. Maamari, Minxian Wang, Eric Boerwinkle, Alanna C. Morrison, Paul S. de Vries, Myriam Fornage, Lifang Hou, Donald M. Lloyd-Jones, Bruce M. Psaty, Russell P. Tracy, Joshua C. Bis, Ramachandran S. Vasan, Daniel Levy, Nancy Heard-Costa, Stephen S. Rich, Xiuqing Guo, Kent D. Taylor, Richard A. Gibbs, Jerome I. Rotter, Cristen J. Willer, Elizabeth C. Oelsner, Andrew E. Moran, Gina M. Peloso, Pradeep Natarajan, Amit V. Khera
Journal: JAMA Cardiology (2023)

Protein-truncating variants (PTVs) in apolipoprotein B (APOB) and proprotein convertase subtilisin/kexin type 9 (PCSK9) are associated with significantly lower low-density lipoprotein (LDL) cholesterol concentrations. The association of these PTVs with coronary heart disease (CHD) warrants further characterization in large, multiracial prospective cohort studies.
Solitary Accessory Spleen-Like Metastasis Coexisted With Splenic Infarction Reveled on 18F-FDG PET/CT in a Hepatocellular Carcinoma Patient
Authors: Fuqiang Shao, Peng Xie
Journal: Clinical Nuclear Medicine (2023)

Solitary parasplenic metastatic carcinoma may be misinterpreted as accessory spleen on CT images. In addition, elevated FDG uptake in the spleen may also mimic metastasis in patient with a history of carcinoma. Here we present a case of parasplenic metastasis coexisted with splenic infarction reveled on 18F-FDG PET/CT in a 51-year-old man with history of hepatocellular carcinoma.
Remarkable FDG Uptake in Numerous Granulomatous Panniculitis Lesions
Authors: Soheila Erfani, Habibollah Dadgar, A. Reza Khorasanchi, Salman Soltani, Atena Aghaee
Journal: Clinical Nuclear Medicine (2022)

Abstract A 42-year-old woman with history of rheumatoid arthritis and erythema nodosum from 8 years ago, who was treated with CellCept and prednisolone, was admitted to the rheumatology service due to skin lesions in the upper and lower extremities. Skin excisional biopsy was performed, and the results suggested panniculitis. FDG PET/CT was performed for malignancy workup. The scan images revealed intensely increased FDG uptake in all numerous subcutaneous nodules. FDG uptake in the panniculitis lesion is rarely reported in the literature.
Treatment of <scp>COVID</scp>‐19 patients with a <scp>SARS‐CoV</scp>‐2‐specific <scp>siRNA</scp>‐peptide dendrimer formulation
Authors: Musa Khaitov, Alexandra Nikonova, Ilya Kofiadi, Igor Shilovskiy, Valeriy Smirnov, Olga Elisytina, Artem Maerle, Artem Shatilov, Anastasia Shatilova, Sergey Andreev, Ilya Sergeev, Dmitry Trofimov, Tatyana Latysheva, Natalia Ilyna, Alexander Martynov, Sevastyan Rabdano, Ellina Ruzanova, Nikita Savelev, Iuliia Pletiukhina, Ariana Safi, Vyacheslav Ratnikov, Viktor Gorelov, Viktor Kaschenko, Natalya Kucherenko, Irina Umarova, Svetlana Moskaleva, Sergei Fabrichnikov, Oleg Zuev, Nikolai Pavlov, Daria Kruchko, Igor Berzin, Dmitriy Goryachev, Vadim Merkulov, German Shipulin, Sergey Udin, Victor Trukhin, Rudolf Valenta, Veronica Skvortsova
Journal: Allergy (2023)

Severe acute respiratory syndrome corona virus (SARS-CoV-2) infection frequently causes severe and prolonged disease but only few specific treatments are available. We aimed to investigate safety and efficacy of a SARS-CoV-2-specific siRNA-peptide dendrimer formulation MIR 19® (siR-7-EM/KK-46) targeting a conserved sequence in known SARS-CoV-2 variants for treatment of COVID-19.We conducted an open-label, randomized, controlled multicenter phase II trial (NCT05184127) evaluating safety and efficacy of inhaled siR-7-EM/KK-46 (3.7 mg and 11.1 mg/day: low and high dose, respectively) in comparison with standard etiotropic drug treatment (control group) in patients hospitalized with moderate COVID-19 (N = 52 for each group). The primary endpoint was the time to clinical improvement according to predefined criteria within 14 days of randomization.Patients from the low-dose group achieved the primary endpoint defined by simultaneous achievement of relief of fever, normalization of respiratory rate, reduction of coughing, and oxygen saturation of >95% for 48 h significantly earlier (median 6 days; 95% confidence interval [CI]: 5-7, HR 1.75, p = .0005) than patients from the control group (8 days; 95% CI: 7-10). No significant clinical efficacy was observed for the high-dose group. Adverse events were reported in 26 (50.00%), 25 (48.08%), and 28 (53.85%) patients from the low-, high-dose and control group, respectively. None of them were associated with siR-7-EM/KK-46.siR-7-EM/KK-46, a SARS-CoV-2-specific siRNA-peptide dendrimer formulation is safe, well tolerated and significantly reduces time to clinical improvement in patients hospitalized with moderate COVID-19 compared to standard therapy in a randomized controlled trial.
Molecular characterization of allergens and component‐resolved diagnosis of <scp>IgE</scp>‐mediated mango fruit allergy
Authors: Lan Zhao, Hanbing Xie, Xuefeng Wang, Meiling Liu, Tingting Ma, Wanyi Fu, Yuqi Wang, Dongya Wu, Yan Feng, Yi Liu, Shandong Wu, Xianqi Zhang, Huiying Wang, Fangmei Luo, Baohua Guo, Hongxia Wu, Yongmei Yu, Linglin Fu, Rudolf Valenta, Susanne Vrtala, Ronald van Ree, Xueyan Wang, Zhongshan Gao
Journal: Allergy (2023)

Appendix S1. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Machine learning model for predicting outcomes of biologic therapy in psoriasis
Authors: Amy X. Du, Zarqa Ali, Kawa K. Ajgeiy, Maiken G. Dalager, Tomas N. Dam, Alexander Egeberg, Christoffer V.S. Nissen, Lone Skov, Simon Francis Thomsen, Sepideh Emam, Robert Gniadecki
Journal: Journal of the American Academy of Dermatology (2023)
Prostate Cancer Recurrence and Persistence After Irreversible Electroporation Focal Ablation
Authors: Sumit Isharwal, Kirsten L. Greene
Journal: JAMA Surgery (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
<i>Candida albicans</i> can foster gut dysbiosis and systemic inflammation during HIV infection
Authors: Silvere D Zaongo, Jing Ouyang, Stéphane Isnard, Xin Zhou, Vijay Harypursat, Hongjuan Cui, Jean-Pierre Routy, Yaokai Chen
Journal: Gut Microbes (2023)

Candida albicans (C. albicans) is a ubiquitous fungal commensal component of the human microbiota, and under certain circumstances, such as during an immunocompromised state, it may initiate different types of infection. Moreover, C. albicans continuously and reciprocally interacts with the host immune system as well as with other elements of the gut microbiota, thus contributing significantly to both gut homeostasis and host immunity. People living with HIV (PLWH), including those receiving antiretroviral therapy, are characterized by a depletion of CD4 + T-cells and dysbiosis in their gut. C. albicans colonization is frequent in PLWH, causing both a high prevalence and high morbidity. Gut barrier damage and elevated levels of microbial translocation are also fairly common in this population. Herein, we take a closer look at the reciprocity among C. albicans, gut microbiota, HIV, and the host immune system, thus throwing some light on this complex interplay.
Superscan-Like Pattern on 18F-Choline PET/CT in a Patient With Essential Thrombocythemia
Authors: Luca Urso, Alberto Nieri, Francesca Borgia, Antonio Malorgio, Mirco Bartolomei
Journal: Clinical Nuclear Medicine (2022)

Abstract Few clinical and preclinical articles reported the potential usefulness of 18 F-choline PET/CT in several hematological proliferative diseases. We report and incidental finding of a superscan-like pattern in a patient affected by essential thrombocythemia (ET), performing 18 F-choline PET/CT for a biochemical recurrence of prostate cancer. The mild elevation of PSA values and the negativity of subsequent 68 Ga-PSMA-11 PET/CT allowed to correlate the diffuse skeletal uptake detected on 18 F-choline PET/CT to the underlying hematologic disease, rather than to a prostate cancer relapse.
Long-term Exposure to Multiple Ambient Air Pollutants and Association With Incident Depression and Anxiety
Authors: Teng Yang, Jiawei Wang, Jing Huang, Frank J. Kelly, Guoxing Li
Journal: JAMA Psychiatry (2023)

Air pollution is increasingly recognized as an important environmental risk factor for mental health. However, epidemiologic evidence on long-term exposure to low levels of air pollutants with incident depression and anxiety is still very limited.