AB0827 Frequency of sexual dysfunction axial spondyloarthritis, Santo Domingo, Dominican Republic
Authors: A. Cornelio, T. Polanco Mora, J. Santana Peralta, R. A. Alvarez Santana, D. Garcia, E. Rodriguez Bautista, I. Paulino, L. Concepción Sanchez, I. Mercedes, T. Valdez, A. Feriz, R. Muñoz Louis
Journal: Annals of the Rheumatic Diseases (2022)

Background Axial spondyloarthritis (SpAa) is a chronic inflammatory disease of unknown etiology that affects the axial skeleton, affecting peripheral joints, entheses and extra-articular structures, with a prevalence of 0.5-1% associated with HLA-B27+. 1 The impact of Chronic disease is often multifactorial that affects physical, hormonal and psychological alterations, leading to problems of sexuality. 2 The CSFQ-14 (Changes in Sexual Functioning Questionnaire), evaluates changes in sexual functioning due to disease and/or or treatment in 5 domains with a score range of 14-70; cut-off point indicating sexual dysfunction &lt;41 men and &lt;47 women. 3,4 Objectives To evaluate the frequency and degree of sexual dysfunction in patients with axial spondyloarthritis. Methods Prospective, observational, cross-sectional study. of the SpAa cohort of the Hospital Docente Padre Billini rheumatology service Patients were interviewed in July 2021. Inclusion criteria: &gt; 18 years, diagnosis of SpAa according to the ASAS 2009 classification criteria, at least 1 sexual. Exclusion criteria: previous diagnosis of another autoimmune disease, depression, diabetes mellitus (DM), treatment with antidepressants, antiepileptics, narcotics. Measurement of: CSFQ-14, BASDAI. Statistical analysis was performed with the Pearson correlation (r P ) with p&gt;0.05. The data was analyzed by SPSS V23. Results Of the SpAa cohort, 87 met the inclusion criteria. Male 67.8% (59), female 32.2% (28), mean age 45.7±8 years, mean diagnosis 7, married 67.8%(59), single 24.1%(21), widowed 8%(7), HLA-B27 + 51.1 %, hypertension 8% (7), diabetes 6.8% (6), dyslipidemia 10.3%(9), smokers 4.5%(4), 100% (87) bDMARD´s, 13.6% (12) combined with csDMARD´s, Frequency of sexual dysfunction 24.1%(21). Sexual dysfunction in women 6.9% (6) and men 17.2% (15) by CSFQ-14. Global domains: Desire/Interest 2.3% (2), Desire/Frequency 2.3% (2), Pleasure 5.7% (5), Arousal 2.3% (2), Orgasm/Completion 2.3% (2). Female: Desire/interest 6.8% (4), desire/Frequency 3.4% (2), pleasure 8.5% (5). Male: Desire/interest 3.4% (2), desire/Frequency 3.4% (2), pleasure 8.5% (5), arousal 6.8% (4), orgasm/completion 3.4% (2). Correlation CSFQ-14 domains with BASDAI: r p =. -0.088 p&gt;0.05: Desire/interest dysfunction: inactive BASDAI 71.4% (15). Desire/frequency: inactive BASDAI 90.5% (20). Pleasure: inactive BASDAI 23.8% (5), active 23.8% (5). Excitation: inactive BASDAI 14.3% (3). Orgasm/completion&gt; inactive BASDAI 90.5% (20) Conclusion The study showed a low frequency of sexual dysfunction, being more frequent in males. The greatest dysfunction was found in the pleasure domain in both sexes. A statistically significant inverse linear association was found between sexual dysfunction and disease activity. References [1]Gunaydin, R., Karatepe, AG, Cesmeli, N. &amp; Kaya, T. Fatiga en pacientes con espondilitis anquilosante: relaciones con variables específicas de la enfermedad, depresión y trastornos del sueño. Reumatología clínica 28, 1045-1051 (2009). [2]Helland, Y. et al. Enfermedades reumáticas y sexualidad: impacto de la enfermedad y estrategias de autocuidado. Arthritis Care Res. (Hoboken)63, 743–750 (2011). [3]Badley EM (2008) Enhancing the conceptual clarity of the activity and participation components of the International Classification of Functioning, Disability and Health. Soc Sci Med 66: 2335–2345 [4]Clayton AH, McGarvey EL, Clavet GJ. The Changes in Sexual Functioning Questionnaire (CSFQ): development, reliability, and validity. Psychopharmacol Bull. 1997;33(4):731-45. PMID: 9493486. Disclosure of Interests None declared