POS0704 RISK FACTORS OF DEPRESSION AND ANXIETY IN PATIENTS WITH TAKAYASU ARTERITIS
Authors: Z. Yaxin, L. Pan
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Takayasu arteritis (TA) is associated with an increased risk of developing complicated comorbidities, which can bring both psychological and physical burdens to the patients. Most cases are young female patients with an onset age of 10 to 40 years [1]. Psychological disorders have long been recognized as important comorbidities of immune diseases. In the case of rheumatoid progress, comorbid depression and anxiety would increase the mortality and heighten the medication, prognostic and economic burden. In patients with TA, there haven't been identified whether comorbid depression and anxiety may lead to an inaccurate evaluation of disease status and lower quality of life [2-5]. The emotional state generated by the TA should not be ignored. The primary aim of this study was to investigate the risk factors of comorbid depression and anxiety in patients with TA. <h3>Objectives</h3> The research is to investigate risk factors of comorbid depression and anxiety in patients with Takayasu arteritis. <h3>Methods</h3> In this observational, longitudianl cohort study, 86 TAK cases were respectively divided into two groups with or without depression and anxiety to identify the risk factors. The Zung Self-Rating Depression and Anxiety Scale (SDS/SAS) are widely applied in many medical researches related to mental health, which displays convincing results and a remarkable degree of consensus on the diagnosis of mood disorders. <h3>Results</h3> Individual patient data were available from 86 subjects, of whom 23 had depression, and 15 had anxiety. Depression was independently associated with Carotidynia, elevated IL-6, and decreased Hb (OR [95%CI] 7.116 [11.508–33.586], p=0.0010; OR [95%CI] 6.669 [1.746–25.470], p=0.005; OR [95%CI] 3.882[1.214–12.420], p=0.020) respectively. We used correlation analysis to find out the association between the level of IL-6 with SDS, SAS scores (r=0.337, p=0.002; r=0.280, p=0.010). The levels of Completement 3, NIH, ITAS.A and ITAS2010 were similarly correlated with SDS score (r=0.232, p=0.032; r=0.280, p=0.009; r=0.332, p=0.002; r=0.323, p=0.002), which wasn't seemed in SAS score. <h3>Conclusion</h3> Clinicians should be alert to risk factors for predisposing patients to mood disorders. TA patients comorbid depression and anxiety should be given more positive treatment to essentially control the disease to improve their emotional state and quality of life. <h3>References</h3> [1]Vanoli M, Bacchiani G, Origg L, Scorza R. Takayasu's arteritis: a changing disease. Journal of nephrology. 2001;14(6):497-505. [2]Nerurkar L, Siebert S, McInnes IB, Cavanagh J. Rheumatoid arthritis and depression: an inflammatory perspective. The Lancet Psychiatry. 2019;6(2):164-73. [3]Matcham F, Rayner L, Steer S, Hotopf M. The prevalence of depression in rheumatoid arthritis: a systematic review and meta-analysis. Rheumatology. 2013;52(12):2136-48. [4]Zhang L, Fu T, Yin R, Zhang Q, Shen B. Prevalence of depression and anxiety in systemic lupus erythematosus: a systematic review and meta-analysis. BMC psychiatry. 2017;17(1):1-14. [5]Moustafa AT, Moazzami M, Engel L, Bangert E, Hassanein M, Marzouk S, et al., editors. Prevalence and metric of depression and anxiety in systemic lupus erythematosus: a systematic review and meta-analysis. Seminars in arthritis and rheumatism; 2020: Elsevier. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.