tbuckley/cabot-search huggingface dataset:
Letter to the Editor: What is the actual role of decompensated cirrhosis in the breakthrough SARS-CoV-2 infection?
Authors: Yue Hu, Zheng Li, Weilan He, Xin Wang, Xinran Cheng
Journal: Hepatology (2023)

1Department of Paediatric Genetics, Endocrinology and Metabolism, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China 2Division of Thoracic Tumor Multimodality Treatment and Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China Data availability statement: The data that support the findings of this study are all included in this article. Yue Hu and Zheng Li: Contributed equally as co-first authors. Correspondence Xinran Cheng, Chengdu Women's and Children's Central Hospital, Riyue Road 1617#, Qingyang District, Chengdu 610073, China. Email: [email protected]
A TGF-β–dominant chemoresistant phenotype of hepatoblastoma associated with aflatoxin exposure in children
Authors: Xiao Xiang, Yijie Hao, Cheng Cheng, Huanjing Hu, Huadong Chen, Jiehui Tan, Yuanqi Wang, Xiaofei Liu, Bo Peng, Junbin Liao, Ji Wang, Yubin Xie, Juncheng liu, Shuling Chen, Lixia Xu, Wenxuan Xie, Ruidong Xue, Ming Kuang, Zhe Xu, Hong Jiang, Sui Peng
Journal: Hepatology (2023)

Background and Aims: Hepatoblastoma (HB) is the most common liver cancer in children, posing a serious threat to children’s health. Chemoresistance is the leading cause of mortality in patients with HB. A more explicit definition of the features of chemotherapy resistance in HB represents a fundamental urgent need. Approach and Results: We performed an integrative analysis including single-cell RNA sequencing, whole-exome sequencing, and bulk RNA sequencing in 180 HB samples, to reveal genomic features, transcriptomic profiles, and the immune microenvironment of HB. Multicolor immunohistochemistry staining and in vitro experiments were performed for validation. Here, we reported four HB transcriptional subtypes primarily defined by differential expression of transcription factors. Among them, the S2A subtype, characterized by strong expression of progenitor ( MYCN , MIXL1 ) and mesenchymal transcription factors ( TWIST1 , TBX5 ), was defined as a new chemoresistant subtype. The S2A subtype showed increased TGF-β cancer-associated fibroblast and an immunosuppressive microenvironment induced by the upregulated TGF-β of HB. Interestingly, the S2A subtype enriched SBS24 signature and significantly higher serum aflatoxin B1-albumin (AFB1-ALB) level in comparison with other subtypes. Functional assays indicated that aflatoxin promotes HB to upregulate TGF-β. Furthermore, clinical prognostic analysis showed that serum AFB1-ALB is a potential indicator of HB chemoresistance and prognosis. Conclusions: Our studies offer new insights into the relationship between aflatoxin and HB chemoresistance and provide important implications for its diagnosis and treatment.
Role of Human Epicardial Adipose Tissue–Derived miR-92a-3p in Myocardial Redox State
Authors: Maria Cristina Carena, Ileana Badi, Murray Polkinghorne, Ioannis Akoumianakis, Costas Psarros, Elizabeth Wahome, Christos P. Kotanidis, Nadia Akawi, Alexios S. Antonopoulos, Jagat Chauhan, Rana Sayeed, George Krasopoulos, Vivek Srivastava, Shakil Farid, Nicholas Walcot, Gillian Douglas, Keith M. Channon, Barbara Casadei, Charalambos Antoniades
Journal: Journal of the American College of Cardiology (2023)

Visceral obesity is directly linked to increased cardiovascular risk, including heart failure. This study explored the ability of human epicardial adipose tissue (EAT)-derived microRNAs (miRNAs) to regulate the myocardial redox state and clinical outcomes. This study screened for miRNAs expressed and released from human EAT and tested for correlations with the redox state in the adjacent myocardium in paired EAT/atrial biopsy specimens from patients undergoing cardiac surgery. Three miRNAs were then tested for causality in an in vitro model of cardiomyocytes. At a clinical level, causality/directionality were tested using genome-wide association screening, and the underlying mechanisms were explored using human biopsy specimens, as well as overexpression of the candidate miRNAs and their targets in vitro and in vivo using a transgenic mouse model. The final prognostic value of the discovered targets was tested in patients undergoing cardiac surgery, followed up for a median of 8 years. EAT miR-92a-3p was related to lower oxidative stress in human myocardium, a finding confirmed by using genetic regulators of miR-92a-3p in the human heart and EAT. miR-92a-3p reduced nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase–derived superoxide (O2.–) by targeting myocardial expression of WNT5A, which regulated Rac1-dependent activation of NADPH oxidases. Finally, high miR-92a-3p levels in EAT were independently related with lower risk of adverse cardiovascular events. EAT-derived miRNAs exert paracrine effects on the human heart. Indeed miR-92a-3p suppresses the wingless-type MMTV integration site family, member 5a/Rac1/NADPH oxidase axis and improves the myocardial redox state. EAT-derived miR-92a-3p is related to improved clinical outcomes and is a rational therapeutic target for the prevention and treatment of obesity-related heart disease.
Fall Outcomes With Left Atrial Appendage Occlusion vs Direct Oral Anticoagulants for Atrial Fibrillation
Authors: Wenjun Deng, Moussa Mansour, Bo Song, Haiman Hou, Kai Liu, YuMing Xu, David McMullin, Ferdinando S. Buonanno, Eng H. Lo, MingMing Ning
Journal: Journal of the American College of Cardiology (2023)
Complete Revascularization and Angina-Related Health Status in the ISCHEMIA Trial
Authors: Kreton Mavromatis, Philip G. Jones, Ziad A. Ali, Gregg W. Stone, Grace M. Rhodes, Sripal Bangalore, Sean O’Brien, Philippe Genereux, Jennifer Horst, Ovidiu Dressler, Shaun Goodman, Karen Alexander, Anoop Mathew, Jiyan Chen, Balram Bhargava, Amar Uxa, William E. Boden, Daniel B. Mark, Harmony R. Reynolds, David J. Maron, Judith S. Hochman, John A. Spertus
Journal: Journal of the American College of Cardiology (2023)
Development of the Implantable Cardioverter-Defibrillator
Authors: Barry J. Maron, N.A. Mark Estes, Ethan J. Rowin, Martin S. Maron, Matthew R. Reynolds
Journal: Journal of the American College of Cardiology (2023)

Implantable cardioverter-defibrillators (ICDs) represent transformational technology, arguably the most significant advance in cardiovascular medicine in 50 years. The vision and determination of pioneers Mirowski and Mower was fundamental to this monumental achievement, working with limited resources and confronted by skepticism/criticism from medical establishment. The inventors were followed >35 years in which a multitude of innovative clinical scientists and engineers introduced technological advances leading to the sophisticated devices in practice today. A pivotal patient experiment with automated termination of ventricular fibrillation (1980) led to U.S. Food and Drug Administration approval. Transvenous lead systems converted ICDs from thoracotomy-based secondary prevention to primary prevention of sudden death devices in countless patients worldwide. ICD acceptance was solidified by prospective randomized controlled trials showing reduced mortality superior to antiarrhythmic drugs. ICDs eventually expanded from coronary disease to inherited arrhythmia conditions (eg, hypertrophic cardiomyopathy). The ICD breakthrough story demonstrates how significant progress is possible in medicine against all odds, given fearless imagination to pursue novel ideas that conflict with accepted wisdom.
Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation
Authors: Frank Qian, Nathan Tintle, Paul N. Jensen, Rozenn N. Lemaitre, Fumiaki Imamura, Tobias Rudholm Feldreich, Sarah Oppeneer Nomura, Weihua Guan, Federica Laguzzi, Eunjung Kim, Jyrki K. Virtanen, Marinka Steur, Christian S. Bork, Yoichiro Hirakawa, Michelle L. O'Donoghue, Aleix Sala-Vila, Andres V. Ardisson Korat, Qi Sun, Eric B. Rimm, Bruce M. Psaty, Susan R. Heckbert, Nita G. Forouhi, Nicholas J. Wareham, Matti Marklund, Ulf Risérus, Lars Lind, Johan Ärnlöv, Parveen Garg, Michael Y. Tsai, James Pankow, Jeffrey R. Misialek, Bruna Gigante, Karin Leander, Julie A. Pester, Christine M. Albert, Maryam Kavousi, Arfan Ikram, Trudy Voortman, Erik B. Schmidt, Toshiharu Ninomiya, David A. Morrow, Antoni Bayés-Genís, James H. O’Keefe, Kwok Leung Ong, Jason H.Y. Wu, Dariush Mozaffarian, William S. Harris, David S. Siscovick
Journal: Journal of the American College of Cardiology (2023)
Mitigating neurological, cognitive, and psychiatric sequelae of COVID-19-related critical illness
Authors: Pratik Pandharipande, Shawniqua Williams Roberson, Fiona E Harrison, Jo Ellen Wilson, Julie A Bastarache, E Wesley Ely
Journal: The Lancet Respiratory Medicine (2023)

Despite advances in the treatment and mitigation of critical illness caused by infection with SARS-CoV-2, millions of survivors have a devastating, post-acute infection syndrome known as long COVID. A large proportion of patients with long COVID have nervous system dysfunction, which is also seen in the distinct but overlapping condition of post-intensive care syndrome (PICS), putting survivors of COVID-19-related critical illness at high risk of long-lasting morbidity affecting multiple organ systems and, as a result, engendering measurable deficits in quality of life and productivity. In this Series paper, we discuss neurological, cognitive, and psychiatric sequelae in patients who have survived critical illness due to COVID-19. We review current knowledge of the epidemiology and pathophysiology of persistent neuropsychological impairments, and outline potential preventive strategies based on safe, evidence-based approaches to the management of pain, agitation, delirium, anticoagulation, and ventilator weaning during critical illness. We highlight priorities for current and future research, including possible therapeutic approaches, and offer considerations for health services to address the escalating health burden of long COVID.
Annals Consult Guys - Can You Stop Heart Failure Medications if the Ejection Fraction Recovers?
Authors: Howard H. Weitz, Geno J. Merli
Journal: Annals of Internal Medicine (2023)

Web ExclusivesJuly 2023Annals Consult Guys - Can You Stop Heart Failure Medications if the Ejection Fraction Recovers?FREEHoward H. Weitz, MD, and Geno J. Merli, MDHoward H. Weitz, MDThomas Jefferson University, Philadelphia, Pennsylvania (H.H.W., G.J.M.)Search for more papers by this author, and Geno J. Merli, MDThomas Jefferson University, Philadelphia, Pennsylvania (H.H.W., G.J.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W22-0020 CME/MOC SectionsSupplemental MaterialAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The Annals Consult Guys discuss whether it is safe to discontinue heart failure medications in a patient whose ejection fraction has recovered after treatment of heart failure with reduced ejection fraction as a result of idiopathic dilated cardiomyopathy.For more videos from and information on Annals Consult Guys, visit go.annals.org/ConsultGuys. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAuthors: Howard H. Weitz, MD; Geno J. Merli, MDAffiliations: Thomas Jefferson University, Philadelphia, Pennsylvania (H.H.W., G.J.M.)Disclosures: Drs. Merli and Weitz report that they have no financial relationships or interests to disclose. All relevant financial relationships have been mitigated. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=W22-0020.Editors' Disclosures: The editors have no relevant financial relationships to disclose. Individual forms may be viewed at www.annals.org/editorsdisclosures. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Current IssueJuly 2023Volume 176, Issue 7 ePublished: 18 July 2023 Issue Published: July 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.Loading ...
Annals On Call - Firearm Safety
Authors: Robert M. Centor, Sue S. Bornstein
Journal: Annals of Internal Medicine (2023)

Web ExclusivesJuly 2023Annals On Call - Firearm SafetyFREERobert M. Centor, MD, and Sue S. Bornstein, MDRobert M. Centor, MDHuntsville Regional Medical Campus, University of Alabama Birmingham School of Medicine, Birmingham, Alabama (R.M.C.)Search for more papers by this author, and Sue S. Bornstein, MDTexas Medical Home Initiative, Dallas, Texas (S.S.B.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/A22-0014 CME/MOC SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In this episode of Annals On Call, Dr. Centor discusses strategies that physicians can implement for preventing firearm injury in their patients with Dr. Sue Bornstein.Annals articles discussed include...Firearm Injury: An Escalating Health Crisis: https://www.acpjournals.org/doi/10.7326/M23-0127Firearm Injury in the United States: Time to Confront It as the Epidemic It Has Become: https://www.acpjournals.org/doi/10.7326/M22-0865Reducing Firearm Injuries and Deaths in the United States: A Position Paper From the American College of Physicians: https://www.acpjournals.org/doi/10.7326/M18-1530About Annals On CallAnnals On Call focuses on a clinically influential article published in Annals of Internal Medicine. Dr. Robert Centor shares his own perspective on the material and interviews topic area experts to discuss, debate, and share diverse insights about patient care and health care delivery.For more information on Annals On Call and for more episodes, visit go.annals.org/OnCall. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAuthors: Robert M. Centor, MD; Sue S. Bornstein, MDAffiliations: Huntsville Regional Medical Campus, University of Alabama Birmingham School of Medicine, Birmingham, Alabama (R.M.C.)Texas Medical Home Initiative, Dallas, Texas (S.S.B.)Disclosures: All relevant financial relationships have been mitigated. Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=A22-0014.Editors' Disclosures: The editors have no relevant financial relationships to disclose. Individual forms may be viewed at www.annals.org/editorsdisclosures. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoReducing Firearm Injuries and Deaths in the United States: A Position Paper From the American College of Physicians Renee Butkus , Robert Doherty , and Sue S. Bornstein , for the Health and Public Policy Committee of the American College of Physicians* Firearm Injury in the United States: Time to Confront It as the Epidemic It Has Become Christine Laine and Sue S. Bornstein Firearm Injury: An Escalating Health Crisis Christine Laine and Sue S. Bornstein Metrics July 2023Volume 176, Issue 7 ePublished: 18 July 2023 Issue Published: July 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.Loading ...
A pull versus push framework for reputation
Authors: Jillian J. Jordan
Journal: Trends in Cognitive Sciences (2023)

Reputation is a powerful driver of human behavior. Reputation systems incentivize 'actors' to take reputation-enhancing actions, and 'evaluators' to reward actors with positive reputations by preferentially cooperating with them. This article proposes a reputation framework that centers the perspective of evaluators by suggesting that reputation systems can create two fundamentally different incentives for evaluators to reward positive reputations. Evaluators may be pulled towards 'good' actors to benefit directly from their reciprocal cooperation, or pushed to cooperate with such actors by normative pressure. I discuss how psychology and behavior might diverge under pull versus push mechanisms, and use this framework to deepen our understanding of the empirical reputation literature and suggest ways that we may better leverage reputation for social good.
An epidemiological introduction to human metabolomic investigations
Authors: Amit D. Joshi, Ali Rahnavard, Priyadarshini Kachroo, Kevin M. Mendez, Wayne Lawrence, Sachelly Julián-Serrano, Xinwei Hua, Harriett Fuller, Nasa Sinnott-Armstrong, Fred K. Tabung, Katherine H. Shutta, Laura M. Raffield, Burcu F. Darst
Journal: Trends in Endocrinology and Metabolism (2023)
Tears Don’t Have So Far to Fall
Authors: Karl C. Wallenkampf
Journal: Annals of Internal Medicine (2023)

Ad LibitumJuly 2023Tears Don’t Have So Far to FallKarl C. Wallenkampf, MD, MAKarl C. Wallenkampf, MD, MAWashington University in St. Louis, St. Louis, MissouriSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M22-3624 Audio Reading - “Tears Don’t Have So Far to Fall” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Tears Don’t Have So Far to Fall” by Karl C. Wallenkampf, MD, MA Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail When I touched it the last time,... Author, Article, and Disclosure InformationAuthors: Karl C. Wallenkampf, MD, MAAffiliations: Washington University in St. Louis, St. Louis, MissouriCorresponding Author: Karl C. Wallenkampf, MD, MA; e-mail, karl.[email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Tears Don’t Have So Far to Fall” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Tears Don’t Have So Far to Fall” by Karl C. Wallenkampf, MD, MA Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics Current IssueJuly 2023Volume 176, Issue 7Page: 1006 ePublished: 18 July 2023 Issue Published: July 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Snow Days
Authors: Eleanor R. Menzin
Journal: Annals of Internal Medicine (2023)

On Being a DoctorJuly 2023Snow DaysEleanor R. Menzin, MDEleanor R. Menzin, MDBoston Children's Hospital, Harvard Medical School, and Longwood Pediatrics, Boston, MassachusettsAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M23-0477 Audio Reading - "Snow Days" Audio. Virginia L. Hood, MD, a physician from the University of Vermont, reads "Snow Days" by Eleanor R. Menzin, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail As a child growing up 15 miles northwest of Boston, nothing compared to the unfettered joy of a snow day. The radio announced the town's name, the fire station siren horn sounded (because sometimes New England in the 1970s liked to pretend it was the 1870s), and school was canceled. A whole day of playing in the snow, crafting, and baking—of unearned freedom from responsibilities—gifted by Mother Nature.Twenty-five years later, as a primary care physician and mother of three 11 miles west of Boston, nothing filled me with more dread than an impending snow day. I was up at ... Author, Article, and Disclosure InformationAuthors: Eleanor R. Menzin, MDAffiliations: Boston Children's Hospital, Harvard Medical School, and Longwood Pediatrics, Boston, MassachusettsCorresponding Author: Eleanor R. Menzin, MD, 319 Longwood Avenue, Boston, MA 02115; e-mail, eleanor.menzin@childrens.harvard.edu. PreviousarticleNextarticle Advertisement Audio Reading - "Snow Days" Audio. Virginia L. Hood, MD, a physician from the University of Vermont, reads "Snow Days" by Eleanor R. Menzin, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics July 2023Volume 176, Issue 7Page: 1003-1004 ePublished: 18 July 2023 Issue Published: July 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Head-to-head immunogenicity comparison of an Escherichia coli-produced 9-valent human papillomavirus vaccine and Gardasil 9 in women aged 18–26 years in China: a randomised blinded clinical trial
Authors: Feng-Cai Zhu, Guo-Hua Zhong, Wei-Jin Huang, Kai Chu, Li Zhang, Zhao-Feng Bi, Kong-Xin Zhu, Qi Chen, Ting-Quan Zheng, Ming-Lei Zhang, Sheng Liu, Jin-Bo Xu, Hong-Xing Pan, Guang Sun, Feng-Zhu Zheng, Qiu-Fen Zhang, Xiu-Mei Yi, Si-Jie Zhuang, Shou-Jie Huang, Hui-Rong Pan, Ying-Ying Su, Ting Wu, Jun Zhang, Ning-Shao Xia
Journal: The Lancet Infectious Diseases (2023)
Reflections in a Mirror
Authors: Leslie G. Cohen
Journal: Annals of Internal Medicine (2023)

Ad LibitumJuly 2023Reflections in a MirrorLeslie G. Cohen, MDLeslie G. Cohen, MDChestnut Hill, MassachusettsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M23-0368 Audio Reading - “Reflections in a Mirror” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Reflections in a Mirror” by Leslie G. Cohen, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I’d read that a black obsidian mirrorcan pierce into a soul’s darknessto reveal truth, itself.I wonder what truthsany mirror can tell methat I don’t already know?It would show my eyes, that were once able to detect faint scleral icterus, early asterixis uremic frost neural asymmetry, andnow need a magnifying lens and large-print dictionaryto scan medical journals.It would show my ears, thatcarefully listened to a half-century’s tales of hope and suffering, and once easily identified stenotic mitral valve’s opening snap, Grade 1 cardiac murmurs and significant nuances of tone in patients’ voices, andnow need subtitles on TV movies, and a telephone amplifier.It would ... Author, Article, and Disclosure InformationAuthors: Leslie G. Cohen, MDAffiliations: Chestnut Hill, MassachusettsCorresponding Author: Leslie G. Cohen, MD; e-mail, lgcohen33@hotmail.com. PreviousarticleNextarticle Advertisement Audio Reading - “Reflections in a Mirror” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Reflections in a Mirror” by Leslie G. Cohen, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics July 2023Volume 176, Issue 7Page: 1009 ePublished: 18 July 2023 Issue Published: July 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...