tbuckley/cabot-search huggingface dataset:
The health of the nation
Authors: S. Ibbotson, I. Watt
Journal: BMJ (1991)

Alcohol consumption during pregnancy and infants' development SIR,-In their study Dr F Forrest and colleagues tried to find a relation between alcohol intake during pregnancy and infants' development.'Other factors, however, had to be taken into consideration, such as maternal smoking.Using the Bayley scales of infant development, the authors showed that the mental index was lower (-6 units) for children whose mothers smoked 10-19 cigarettes a day and (-3 units) for those whose mothers smoked .'20cigarettes a day.What I would have liked to know is the clinical importance or consequence of this lower score and whether a child with the lower score is within or outside the normal range for age.If she or he is
Library and information services for small hospitals
Authors: K. M. West
Journal: JAMA (1975)

The quality of medical care is dependent on effective and expeditious information services for physicians and other health workers. Small hospitals have been at a particular disadvantage in this respect, mainly because unit costs of library services have been quite high when delivered on a small scale with traditional resources and methods. The importance of this problem is suggested by the fact that more than half of US hospitals have less than 100 beds, and that library services have been primitive or nonexistent in most of these institutions. Certain recent developments will permit most of these smaller hospitals to provide creditable information services at modest cost. (<i>JAMA</i>232:505-508, 1975)
Nitrous oxide as an analgesic in acute myocardial infarction
Authors: P. L. Thompson
Journal: JAMA (1976)

Nitrous oxide in a concentration of 35% has been shown to ameliorate the pain of acute myocardial infarction. This conclusion was reached on the basis of a double-blind study in 69 patients and a clinical study in an additional 42 patients. The use of nitrous oxide was not accompanied by hemodynamic changes or significant adverse reactions. (<i>JAMA</i>235:924-927, 1976)
Post-Traumatic Stress Disorder
Authors: Robert J. Ursano
Journal: New England Journal of Medicine (2002)

Terrorist attacks require our health care system to prepare for the unspeakable. The primary goal of terrorism is to erode the security of a nation, to disrupt the continuity of society, and to destroy the nation's social capital — its morale, cohesion, and values. Both the health care system and individual physicians are critical to the safety and future of our nation.In this issue of the Journal, Yehuda1 updates our knowledge of post-traumatic stress disorder (PTSD), including its epidemiology, psychological and biologic origins, and treatment. PTSD is not uncommon after many types of traumatic events, from motor vehicle accidents . . .
A Randomized Study with or without Intensified Maintenance Chemotherapy in Patients with Acute Promyelocytic Leukemia Who Had Become Negative for PML-RARα Transcript after Consolidation Therapy: The Japan Adult Leukemia Study Group (JALSG) APL97 Study.
Authors: Norio Asou, Yuji Kishimoto, Hitoshi Kiyoi, Masaya Okada, Yasukazu Kawai, Motohiro Tsuzuki, Kentaro Horikawa, Mitsuhiro Matsuda, Katsuji Shinagawa, Tohru Kobayashi, Shigeki Ohtake, Miki Nishimura, Masatomo Takahashi, Fumiharu Yagasaki, Akihiro Takeshita, Yukihiko Kimura, Masako Iwanaga, Tomoki Naoe, Ryuzo Ohno
Journal: Blood (2006)
Corticosteroids in Bronchiolitis
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cinderella
Authors: Irwin M. Siegel
Journal: JAMA (1982)

She was an unmarried, 32-year-old woman who weighed more than 200 pounds. "I'd like to have my feet fixed during my summer vacation. I have two weeks. Do you think that will be enough time?" She worked in a bank and lived at home with her aging parents. She wanted her bunions corrected. "I really can't afford to take off more time than that. I don't know how Mom and Dad will get along without me, even for that short period. I do all the cooking and house cleaning besides being the major breadwinner. They're really almost totally dependent on me." He had been seeing her for years. Her parents were also his patients. It was true that they depended on her. They had complementary strokes, his on the right, hers on the left. However, what was equally true was her dependence on their dependency. Single and lonely, their need
Effects of Inhaled Acids on Lung Biochemistry
Authors: Jerold A. Last
Journal: Environmental Health Perspectives (1989)

Effects of respirable aerosols of sulfuric acid, ammonium sulfate, sodium sulfite, and ammonium persulfate on lungs of rats are reviewed. The literature regarding interactions between ozone or nitrogen dioxide and acidic aerosols (ammonium sulfate, sulfuric acid) is discussed. An unexpected interaction between nitrogen dioxide and sodium chloride aerosol is also discussed. An attempt is made to identify bases for prediction of how and when acid aerosols might potentiate effects of inhaled gases.
Scientific Sessions
Authors: Richard Mills, H Dunbar Hoskinsjr, Marilyn Miller, Ramachandra Pararajasegaram, Robert Webb, Jay Galst, New York, James Ravin, John Bigger, Allan Jensen, William Mathers, Jowa City, Edward Buckley, George Ellis, New Orleans, Diana Shamis, Oscar Cruz, St Louis, Lawrence Tychsen, Marshall Parks, Albert Biglan, Gail Morton, M Wilsonjr, John Simon, Zane Pollard, Kenneth Tuck, V Co, Arthur Perry, Marcus Soper, William Trawnik, H Hoskins, San Francisco, William Tasman, Paul Lichter, Ann Arbor, Riehard Mil, Evpaddress Dunbar, San Franeiseo, Riehard Mills, Froncie Gutman, Jackson Memorial, Lossin Glaucoma, Riehard Brubaker, Medieal Mayo, Manus Kraft, Spencer Thornton, Kenneth Taylor, Roberto Zaldivar, Douglas Koch, Julian Stevens, Ioannis Pallikaris, Ernest Kornmehl, Michael Gordon, San Diego, Theo Seiler, Richard Lewis, Manin Uram, Harry Quigley, Chandra Garudadri, Rukmini Nagarajan, B Opt, Scott Brodie, Anil Mandal, Roben Stamper, Marcelo Nicolela, Stephen Drance, Thomas Hutchinson, Edward Ajaeger, A Dass, Michael Trese, Alice Mcpherson
Journal: Ophthalmology (1995)
A Mystery
Authors: Richard E. Ando
Journal: JAMA (1969)

<h3>To the Editor:—</h3> One of your prolific letter writers, a "Dr. G. G. Liddle of Bloomington, Hawaii," is pulling your leg (eg,<b>207</b>:2440, 1969). Bloomington has not moved into Hawaii from Illinois or Indiana, and we have not been blessed with the wit of Dr. Liddle, or with his person as a colleague. For your information, Hawaii's place and town names are all in Hawaiian, with a few exceptions, of course. Who is Dr. Liddle? Aloha.
Society Proceedings
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Reply
Authors: Bryan P. Schneider, Molin Wang, George W. Sledge, Robert J. Gray, David A. Flockhart, Kathy D. Miller
Journal: Journal of Clinical Oncology (2009)

1 reported a positive association between the VEGF-2578 AA genotype and overall survival in patients with metastatic breast cancer receiving paclitaxel and bevacizumab.In addition, an association between the VEGF-1154 A allele and superior median overall survival was also reported in patients in the same arm, with each active allele having an additive effect.The authors are to be commended for their novel exploratory analysis of a difficult pharmacogenomic question, in the context of a large prospective randomized trial.Nevertheless, we would like to raise epidemiologic and statistical concerns with regard to the way in which the study was conducted.First, a more conservative formal test of interaction would have been preferred to study the association of the reported vascular endothelial growth factor polymorphisms with the relevant outcomes.This would have been a single test to demonstrate that there was an association with the relevant outcome (overall survival) in the experimental arm but no such association in the control arm.The authors presented data for the experimental arm only, reporting that there was no statistically significant result in the control arm.Second, with the selection of paraffin-embedded tumor blocks for genotyping, the benefits of randomization in eliminating bias are diminished, even if the numbers in each arm are equal.Hence, partic-ularly in this exploratory analysis, controlling for any additional clinically relevant confounders after the univariate analysis would be important.In particular, we note that both polymorphisms predicting for better outcomes were more common in the white population in comparison with the African American population.As reported by the authors, the VEGF 2578 A allele and the VEGF-1154 A allele have respective frequencies of 49% and 33% in the white population, and 24% and 10% in the African American population.The disparity of breast cancer survival between whites and African Americans is well known, 2 and is multifactorial in nature.Ethnic variation and admixture are major concerns in any association study, and thus, a breakdown of the patient genotypes by ethnicity would be useful in assessing the validity of this study.We hope that clarifications of these concerns will strengthen the conclusions of the study.
Circulating cholesterol level and risk of death from cancer in men aged 40 to 69 years. Experience of an international collaborative group
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Klin Monatsbl für Augenheilkunde, Stuttgart
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of anti-infectives in five common operations
Authors: J. M. Perlman
Journal: JAMA (1970)

<h3>To the Editor.—</h3> In a recent study we found that teaching hospitals administer anti-infectives to patients undergoing operations at only a slightly lower rate than nonteaching hospitals. But the rates were surprisingly high for both types of hospitals. The records of 516,064 patients discharged from 1,183 hospitals which participated in the Professional Activity Study (PAS) during 1968 were studied. Each patient studied had one of the following procedures coded as his most important operation: (1) repair of inguinal hernia (40.0), (2) appendectomy (45.1), (3) hemorrhoidectomy (49.3), (4) cholecystectomy (53.5), or (5) total abdominal hysterectomy (72.4).<sup>1</sup>The percent of these patients who received sulfa drugs or antibiotics was determined. The data are shown in the Figure with hospitals grouped according to teaching status. A high proportion of the patients in all hospitals received anti-infectives; for example, nearly half of the patients who underwent cholecystectomy and appendectomy received the drugs. <h3>Comment.—</h3>
Environment adds to challenges facing Desert Shield physicians
Authors: P. Gunby
Journal: JAMA (1991)

HOSTILE WEAPONS aren't the only threat to the forces arrayed against Iraq in this fateful first month of 1991. For nearly 6 months, US military physicians, dental personnel, nurses, and corpsmen have been applying preventive and therapeutic measures against more than a score of potential environmental illness or injury threats. The fact that none of these threats has put any appreciable number of US military people out of action, physicians say, is a tribute to the unit commanders' and the troops' understanding of and compliance with primary preventive measures. Richard A. Mayo, MD, a US Navy captain who commands Fleet Hospital 5 somewhere in Saudi Arabia, attributes this in large part to today's "well educated, well disciplined" all-volunteer US military forces. Both James A. Zimble, MD, the vice admiral who is surgeon general of the US Navy, and Frank F. Ledford, Jr, MD, the lieutenant general who is surgeon general
PATHOGENESIS OF THE SPONTANEOUS ATHEROSCLEROTIC PLAQUE
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1733: Tumor Necrosis Factor Receptor-1 Aggravates Aging-Associated Atherosclerosis
Authors: Lisheng Zhang, Karsten Peppel, Leigh Brian, Neil J Freedman
Journal: Circulation (2008)

Aging is believed to contribute to atherogenesis independently of traditional atherosclerosis risk factors, but the mechanisms responsible for this contribution remain obscure. Although serum tumor necrosis factor (TNF) levels increase with aging, vascular cell TNF receptor-1 (TNFR1) expression does not diminish. For these reasons, we tested the hypothesis that TNFR1 contributes to aging-associated atherosclerosis. To isolate aging of the vascular wall from the effects of prolonged exposure to systemic atherogenic factors, we used carotid arteries from 18-month-old ( aged ) and 8-wk-old ( young ), congenic tnfr1 −/− and WT mice as carotid interposition grafts in congenic 8-wk-old apoe −/− mice. Two weeks post-op, WT carotids developed macrophage-rich neointimal lesions. Area dimensions (mm 2 ) of aged and young specimens, respectively, were: neointima, 0.020 ± 0.009 and 0.010 ± 0.006 (p &lt; 0.02); media, 0.06 ± 0.02 and 0.03 ± 0.01 (p &lt; 0.01); external diameter, 0.45 ± 0.05 and 0.39 ± 0.06 (p &lt; 0.03). Thus, aged arteries showed greater atherosclerosis than young arteries, even at early stages of atherogenesis. ICAM-1 and MCP-1 expression, and macrophage prevalence in aged specimens were 1.9 ± 0.4-fold, 1.9 ± 0.2- and 2.5 ± 0.5-fold more (p &lt; 0.04), respectively, than in young specimens, assessed by quantitative immunofluorescence. Seven wks post-op, neointimal area, macrophage and apoptotic (cleaved caspase-3 + ) cell prevalence, and MMP-9 expression were greater in aged than in young arteries, by 1.6 ± 0.3-, 2.3 ± 0.3-, 2.1 ± 0.7-, and 1.5 ± 0.2-fold (p &lt; 0.04), while neointimal SMC prevalence and collagen content were 2.0 ± 0.2- and 1.7 ± 0.1-fold less (p &lt; 0.04). In contrast, 7-wk-old aged and young tnfr1 −/− carotid grafts had equivalent intimal and medial areas, macrophage and apoptotic (cleaved caspase-3 + ) cell prevalence, VCAM-1 expression, and collagen content. Neointimal and medial areas were less in tnfr1 −/− than in WT arteries, by 2.7 ± 0.5-fold and 1.4 ± 0.1-fold, respectively (p &lt; 0.05). We conclude that arterial wall aging contributes to atherosclerosis through mechanisms related to macrophage recruitment, independently of systemic factors, and that TNFR1 signaling in the arterial wall promotes aging-dependent atherosclerosis.
ADULTERATION OF FOODS AND DRUGS.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Funding/Support
Journal: JAMA Neurology (2016)

Ronald C. Petersen, PhD, MD; Heather J. Wiste, BA; Stephen D. Weigand, MS; Walter A. Rocca, MD, MPH; Rosebud O. Roberts, MB, ChB; Michelle M. Mielke, PhD; Val J. Lowe, MD; David S. Knopman, MD; Vernon S. Pankratz, PhD; Mary M. Machulda, PhD; Yonas E. Geda, MD; Clifford R. Jack Jr, MD
Ueber eingebildete Schwangerschaften.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal