tbuckley/cabot-search huggingface dataset:
Line Missing.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuroticism and Affective Instability: The Same or Different?
Authors: J. D. Miller, P. A. Pilkonis
Journal: American Journal of Psychiatry (2006)

Objective: The purpose of this study was to examine the correlates and consequences of two constructs related to affective experience: neuroticism and affective instability. Method: One hundred thirty-two patients were assessed at intake for axis I and II symptoms, general personality traits, and specific impairments, including impairments in interpersonal functioning. The data included responses to structured and semistructured interviews, self-reports of interpersonal problems, and reports of interpersonal problems from significant others. Clinical ratings of axis I and II symptoms and of impairment were made by using the LEAD (i.e., longitudinal, expert, all data) consensus approach. Ninety-one of the 132 patients were reassessed at 12-month follow-up. Results: Neuroticism and affective instability manifested varied concurrent relations, with neuroticism being strongly related to an anxious, avoidant style and affective instability related to more externalizing personality styles. Prospectively, neuroticism predicted later symptoms, occupational impairment, and global dysfunction, whereas affective instability predicted romantic impairment. Conclusions: The findings suggest that neuroticism and affective instability—which are considered core aspects of personality pathology—are related but distinct constructs with unique correlates and different predictive abilities.
Causalgia.
Journal: BMJ (1971)

airways in the adult cannot always be excluded by routine clinical examination or by simple spirometric tests ofventilatory capacity.In bronchitic patients with little disability it might seem unnecessary to embark on the more complex investiga- tions needed to establish the diagnosis.But diseases of the distal airways are usually progressive and can even lead to disruption of the alveoli, especially if there is a well-developed collateral ventilation to the obstructed units of lung tissue.'Discovery of the peripheral lesion at an early stage could be helpful in prognosis, in the recognition of certain environ- mental hazards to the lung, and perhaps in preventing ultimate disability by treatment.Simpler methods are needed for the diagnosis of narrowing of the peripheral airways.Exercise may actually disguise the fault by improving the distribution of ventilation," but rapid respirations at rest can bring to light an abnormality offunction not evident during quiet breathing.'0Perhaps a practicable diagnostic test for detecting narrowing of the distal airways will eventually be evolved from measure- ments made at fast respiratory rates in resting patients.
American Journal of Clinical Pathology, Indianapolis, Ind
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Doctors East, Doctors West</i>
Journal: New England Journal of Medicine (1947)

This small volume is well named, in that it presents in an interesting and scholarly manner "new aspects" of the Hunters.It portrays the relations between John Hunter and his brother-in-law, Sir Everard Home, and reviews, by analysis of documentary material the controversy concerning the destruc- tion of the Hunter manuscripts.New light is thrown on the character and motives of Sir Everard in explanation of his "infamous act."The essay on William Hunter portrays him not only as a teacher and physician, but also as a prominent citizen and as a man, the friend of the famous people of his day.He lives for us anew through his contacts with those about him.Bibliography and index will increase the usefulness of the volume as an historical study.Physically the book maintains the Schuman standard of excellence.It is an important contribution to medical biography.
Diseases of the Nails
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of Antihypertensive Therapy
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Newly diagnosed and relapsed follicular lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Authors: M. Dreyling, M. Ghielmini, S. Rule, G. Salles, M. Ladetto, S.H. Tonino, K. Herfarth, J.F. Seymour, M. Jerkeman
Journal: Annals of Oncology (2020)
THE METRIC SYSTEM.
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing
Authors: Susana Romao, Nathalie Gasser, Andrea C. Becker, Bruno Guhl, Milica Bajagic, Danusia Vanoaica, Urs Ziegler, Joachim Roesler, Jörn Dengjel, Janine Reichenbach, Christian Münz
Journal: The Journal of Experimental Medicine (2013)
Pneumocystis carinii Pneumonia
Authors: James P. Lillehei
Journal: JAMA (1968)

Respiratory symptoms and diffuse pulmonary infiltrate developed in two patients under treatment for leukemia.<i>Pneumocystis carinii</i>pneumonia was suspected and then confirmed by open-lung biopsy in one and by percutaneous needle biopsy of the lung in the other. Both patients recovered promptly from the pneumonia during a 10- to 14-day course of treatment with intramuscularly administered pentamidine isethionate. In both patients hypoglycemia occurred during treatment, and subcutaneous abscesses at the drug injection sites developed in one patient.
Tobacco control report card fails some Federal entities, gives all tough future assignments
Authors: C. Marwick
Journal: JAMA (1994)

THE REPORT card is in. The student is graded "Fail, needs improvement." Despite the decline in the percentage of men in the United States who smoke cigarettes from 52.5% in 1966 to 28.1% in 1991 (and from 33.9% to 23.5% among women), tobacco control experts from the American Cancer Society, American Heart Association, and American Lung Association say that on the national policy level, not enough has been done to discourage the nicotine habit during the intervening years. A rating of the efforts at tobacco control made over the past three decades by nine federal entities, Congress, and the White House was issued in January by The Coalition on Smoking OR Health, a combined office of the three voluntary health agencies, on the 30th anniversary of the initial report on the hazards of smoking from then—US Surgeon General Luther B. Terry, MD. The rating, formally entitled A<i>30-Year Report Card</i>
PREFACE
Authors: RICHARD S. ROSS
Journal: Circulation (1972)

We all remember Charles K. Friedberg as a most unusual man, but the extreme rarity of men with all his qualities became obvious to those of us charged with finding his replacement.The Publications Committee was proud of the job Dr. Friedberg had done with CIRCULATION and therefore began the search for a replacement by attempting to inventory those attributes which made him such a successful editor.First of all he was a superior clinical cardiologist-a consultant of the old school-a doctor's doctor.He knew what physicians needed to know, and he could tell it in language which was clear, forceful, and to the point.He was a good editor.He made good selections of invited and submitted manuscripts.
Erratum
Authors: None &NA;
Journal: Clinical Nuclear Medicine (1983)

We report a bone scan finding of bilaterally and symmetrically increased uptake at the lateral orbital rims in a patient with disseminated Hodgkin's disease. Computerized axial tomography (CT) demonstrated lacrimal gland enlargement, presumably due to infiltration by Hodgkin's disease. Both the radionuclide bone scan and CT findings, as well as the other physical and radiographic manifestations of Hodgkin's disease, resolved after chemotherapy. Infiltration by Hodgkin's lymphoma is a rare cause of lacrimal gland enlargement. We believe that this pattern of uptake on a routine bone scan should alert the physician to possible lacrimal gland disease, which could then be more definitively evaluated by CT examination.
Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudine in vivo
Authors: G Tipples
Journal: Hepatology (1996)

The (-) enantiomer of 3'-thiacytidine (lamivudine) has been found to be a potent inhibitor of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) replication. Mutation of methionine to valine or isoleucine at the YMDD (tyrosine, methionine, aspartate, aspartate) motif of the HIV reverse transcriptase has been shown to be responsible for lamivudine resistance in HIV. The hepadnaviruses also have the YMDD motif in their DNA polymerase. Therefore, it is possible that hepadnaviruses could develop lamivudine resistance by a similar mutation at this motif. We analyzed the HBV from a liver transplantation patient who developed recurrent HBV viremia during lamivudine treatment. The polymerase gene was amplified by polymerase chain reaction (PCR), and the region coding for the YMDD motif was sequenced. The pretreatment HBV sequence coded for YMDD, while the lamivudine-resistant mutant HBV coded for YIDD (tyrosine, isoleucine, aspartate, aspartate). With the documented changes in the YMDD motif of lamivudine-resistant HIV, it is likely that the methionine-to- isoleucine mutation in the YMDD motif of the HBV polymerase contributes significantly to the lamivudine-resistance of HBV isolated from this patient. (Hepatology 1996 Sep;24(3):714-7)
Puerperal Insanity
Authors: M. D. Macleod
Journal: BMJ (1886)

<h3>Abstract</h3> Women with Systemic Lupus Erythematosus (SLE) show significantly increased cardiovascular risk compared to the general population. However, despite CVD being a major cause of morbidity and mortality for these women, this increased risk is not managed clinically and tools to dissect and predict their cardiovascular risk are lacking. Notably, this elevated CVD risk is not captured by traditional risk factors. To explore molecular programs underlying asymptomatic atherosclerosis in SLE we used a well-characterised cohort of CVD-free women with SLE, scanned for asymptomatic atherosclerotic plaques using non-invasive ultrasound imaging of the carotid and femoral arteries. We investigated the transcriptomic profiles of CD14+ circulating monocytes in women with SLE with or without preclinical atherosclerosis. We identified unique monocytic gene expression profiles that distinguished the presence of preclinical plaques in women with SLE. In addition, advanced bioinformatic analysis revealed functional pathways and interactions between the genes identified that could explain mechanistic differences in plaque formation. We propose that these molecular signatures could help understand why a subset of women with SLE are predisposed to develop atherosclerosis and at higher risk of developing clinical CVD. Collectively with other efforts, these molecular insights will help to better define atherosclerosis in the context of SLE which will be critical for future patient stratification and identification of anti-atherosclerotic therapies.
Major Sources of Benzene Exposure
Authors: Lance A. Wallace
Journal: Environmental Health Perspectives (1989)

Data from EPA's TEAM Study allow us to identify the major sources of exposure to benzene for much of the U.S. population. These sources turn out to be quite different from what had previously been considered the important sources. The most important source of exposure for 50 million smokers is the mainstream smoke from their cigarettes, which accounts for about half of the total population burden of exposure to benzene. Another 20% of nationwide exposure is contributed by various personal activities, such as driving and using attached garages. (Emissions from consumer products, building materials, paints, and adhesives may also be important, although data are largely lacking.) The traditional sources of atmospheric emissions (auto exhaust and industrial emissions) account for only about 20% of total exposure. Environmental tobacco smoke is an important source, accounting for about 5% of total nationwide exposure. A number of sources sometimes considered important, such as petroleum refining operations, petrochemical manufacturing, oil storage tanks, urban-industrial areas, service stations, certain foods, groundwater contamination, and underground gasoline leaks, appear to be unimportant on a nationwide basis.
Studies of Cadmium Uptake and Metabolism by the Kidney
Authors: Kazuo T. Suzuki
Journal: Environmental Health Perspectives (1984)

Our investigation was centered on a possible relationship between the toxicity of cadmium and changes in its chemical forms in tissues. Two models have been studied: one is the renal damage induced by a single injection of cadmium-containing metallothionein and the other is the renal damage induced by repeated injections of cadmium salt. Parenteral loading of cadmium-containing metallothionein caused acute and transitory necrotic damage of renal tubular lining cells. This was explained by the selective and rapid uptake of metallothionein at the proximal tubules and degradation of the protein, resulting in liberation of cadmium ions. Cadmium ions were injected repeatedly into rats, and the changes in the chemical forms of cadmium, zinc and copper in the liver and kidneys were correlated with the histological observations. The transitory necrotic damage of the proximal tubules caused during the repeated injections of cadmium was accompanied with a rapid decrease of the copper content in the kidney metallothionein. Further loading of cadmium ions induced increases in the amounts of cadmium not bound to metallothionein and its oxidation products as well as an increase of the Cd/Zn ratio in metallothionein. With these changes in the chemical forms of cadmium, persistent damage of the kidneys occurred. The transitory renal damage caused both by a single injection of cadmium-containing metallothionein and by repeated injections of cadmium salt can be explained by a limit of the native biosynthetic capacity of metallothionein in the kidney, while the persistent damage appears to be due to a limit of the induced capacity.
Inhibition of Human Squamous Cell Carcinoma Growth In Vivo by Epidermal Growth Factor Receptor Antisense RNA Transcribed From the U6 Promoter
Authors: Y He, Q Zeng, S D Drenning, M F Melhem, D J Tweardy, L Huang, J R Grandis
Journal: JNCI Journal of the National Cancer Institute (1998)

Squamous cell carcinomas of the head and neck (SCCHN), unlike normal mucosal squamous epithelial cells, overexpress epidermal growth factor receptor (EGFR) messenger RNA and protein. EGFR protein is required to sustain the proliferation of SCCHN cells in vitro. To determine whether EGFR expression contributes to tumor growth, we investigated the effect of suppressing EGFR expression in tumor xenografts through in situ expression of antisense oligonucleotides.Intratumoral cationic liposome-mediated gene transfer was used to deliver plasmids capable of expressing sense or antisense EGFR sequences into human head and neck tumors, which were grown as subcutaneous xenografts in nude mice. The oligonucleotides were expressed under the control of the U6 RNA promoter.Direct inoculation of the EGFR antisense (but not the corresponding sense) plasmid construct into established SCCHN xenografts resulted in inhibition of tumor growth, suppression of EGFR protein expression, and an increased rate of apoptosis (programmed cell death). Sustained antitumor effects were observed for up to 2 weeks after the treatments were discontinued.These results suggest that interference with EGFR expression, using an antisense-based gene therapy approach, may be an effective means of treating EGFR-overexpressing tumors, including SCCHN.
Cardiac Electrophysiology: From Cell to Bedside
Authors: Peter T. Kuo
Journal: JAMA (1991)

This book by Drs Zipes and Jalife contains complete and up-to-date information on cardiac electrophysiology. The two chief authors, together with 253 contributors, present fresh, original material, stimulating discussions, and the latest therapeutic measures for a broad range of topics in cardiovascular electrophysiology and disturbances. The book stands out as a unique publication in medicine and cardiology. The gem-packed text has 12 parts, each with three to 20 chapters, that present discussions of molecular physiology and single-channel activity; cellular electrophysiology and impulse propagation; morphological correlations; nervous control; presentation and course of arrhythmias and syndromes; diagnostic studies; and therapy. During the current period of explosive growth in scientific information, many new books on various medical topics would have to be revised or updated almost as soon as they appeared in print. Skirting traditional practice, the editors of this book have devised an innovative approach by inviting their contributing authors to share
Undergraduate Medical Education
Authors: Harry S. Jonas
Journal: JAMA (1990)

The decade of the 1980s was a time of reappraisal for medical education. A number of significant reports, including "Future Directions for Medical Education" from the American Medical Association and "Physicians for the Twenty-First Century" (the GPEP Report) from the Association of American Medical Colleges (AAMC) called for changes in the structure and process of medical education. These reports grew out of the desire to ensure that medical school graduates be able to fit into the changing health care provision system and to meet the health care needs of the future. It is perhaps too early to assess the effect such calls for reform have had on the medical school curriculum and on the graduate. Curriculum changes, such as an increase in small-group, student-centered instructional formats, have been adopted by many schools. Whether the educational product of the medical school, that is, the medical school graduate, is different as a