tbuckley/cabot-search huggingface dataset:
THE NETHERLANDS
Journal: JAMA (1922)

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Quantitation and Visualization of Alkyl Deoxynucleosides in the DNA of Mammalian Cells by Monoclonal Antibodies
Authors: Jurgen Adamkiewicz, Gertrude Eberle, Namho Huh, Peter Nehls, Manfred F. Rajewsky
Journal: Environmental Health Perspectives (1985)

Conventional radiochromatographic procedures for the quantitation of carcinogen/mutagen-induced structural DNA modifications have a number of limitations. Thus, these techniques for the most part require application of radioactively labeled carcinogens and the use of relatively large amounts of DNA for analysis at low levels of DNA modification. Radiochromatographic methods also preclude analyses at the level of single cells and DNA molecules. Recently developed immunoanalytical methods have improved this situation considerably. Monoclonal antibodies (Mab) characterized by a high substrate specificity and affinity, in combination with radio- and enzyme-immunoassays, or with "immuno-slot-blot" techniques, now permit the detection of femtomole to subfemtomole amounts of, e.g., alkyldeoxynucleosides in small samples of DNA isolated from tissues or cultured cells previously exposed to nonradioactive N-nitroso compounds. Furthermore, selected Mab can be used to quantitate by direct immunofluorescence (with the aid of computer-based image analysis of electronically intensified fluorescence signals), specific alkyldeoxynucleosides in the nuclear DNA of single cells. With this method, the detection limit for the alkylation product O6-ethyldeoxyguanosine (O6-EtdGuo) is presently of the order of 10(2) -10(3) O6-EtdGuo residues per diploid mammalian genome. Individual cells can thus be monitored for the presence of specific carcinogen-DNA adducts, and with respect to their capacity for enzymatic removal of such modified structures from DNA (as exemplified here by the kinetics of the enzymatic elimination of O6-EtdGuo from the DNA of malignant neurogenic rat cell lines). In combination with transmission electron microscopy, Mab also permit direct visualization (via Mab binding sites) of specific carcinogen-modified structures in individual DNA molecules.(ABSTRACT TRUNCATED AT 250 WORDS)
Corrections
Authors: East Suffolk, J Corson, Gt Yarmouth, M Ashken, H Mahindrakar, G Smart, Newcastle Ri, Board.-M Giotal, F Mehta, D Barwick, I Porteous, West Durham, ) - E Jarvis, Newcastle Northern, Ireland Hospitals, Authority.-R Armstrong, R Hamilton, J Connolly, J Hunter, J Mahony, P Thomas, F Wright
Journal: BMJ (1968)
Routine urinalysis: is the dipstick enough?
Journal: JAMA (1985)

<h3>To the Editor.—</h3> We agreed with the conclusions and recommendations of the article "Routine Urinalysis" by Shaw et al,<sup>1</sup>but we would like to comment on one aspect of the article. The authors stated that "many of these patients suffered from more than one disease process. Thus, the total false-negative rate of the Chemstrip may be considerably lower in other settings where relatively more healthy individuals, or those in the early stages of a single disease, are seen." This is certainly true, because their false-negative rate is derived by dividing the number of false-negatives by total number of cases tested. If the proportion of healthy individuals is increased in the tested population, clearly this false-negative rate must decrease. Obviously, among the healthy there can be no false-negatives; there can only be true-negatives and false-positives. If testing had been done on a relatively healthy population, the false-negative rate of 3.3%
TRANSMISSION OF TUBERCULOSIS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Self-Assessment Tests
Journal: JAMA (1970)

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INSTRUCTION IN OPERATIVE MEDICINE.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of refractory reticulum cell sarcoma with low doses of vincristine sulfate
Authors: W. J. Yount
Journal: JAMA (1966)

Small doses of vincristine sulfate produced dramatic improvement in patients with far-advanced reticulum cell sarcoma which previously had been resistant to other forms of therapy. The maximal initial dose was 25μg/kg body weight weekly; maintenance levels have been as low as 5μg/kg biweekly. This dosage schedule permitted prolonged courses of therapy and minimized toxicity, thus providing sustained antitumor effect. In one patient with disseminated reticulum cell sarcoma refractory to alkylating agents and irradiation, a 17-month course of therapy was tolerated without toxicity. Death, due to unrelated causes, occurred 29 months after initiation of vincristine; no tumor was found at autopsy. It is suggested that vincristine, given in small doses for weeks or months, is a systemic agent worthy of consideration for the primary therapy of generalized reticulum cell sarcoma.
Cardiac Infarction With Increased Transaminase Level and Without Electrocardiographic Signs of Necrosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Assessing Evidence for Physician Orders for Life-Sustaining Treatment Programs—Reply
Authors: Kendra A. Moore, Emily B. Rubin, Scott D. Halpern
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The foot process of the renal glomerulus
Authors: R. O. Ores
Journal: JAMA (1969)

<h3>To the Editor:—</h3> For seven years I have been interested in the ultrastructure of the kidney and my work has been rewarded with a finding that I would like to share with the readers ofThe Journal. I have discovered why the cytoplasmic extensions of the epithelial cells in the glomeruli are called foot processes. One can see this clearly from the electron micrograph (Figure). In future work I shall endeavor to find the rest of the lady.
Actinomycosis of the urinary bladder. Association with an intrauterine contraceptive device
Authors: D. T. King
Journal: JAMA (1978)

ACTINOMYCOSIS of the female genital tract has followed the use of intrauterine contraceptive devices (IUDs).<sup>1</sup>Though actinomycosis from this source occasionally spreads to other areas in the abdomen and thorax, it rarely extends to the urinary tract, where the kidney is more often affected than the ureters or bladder. Actinomycosis of the bladder, though most uncommon, may imitate malignant neoplasms because it presents as multiple fistulas or as a mass lesion. We describe actinomycosis of the urinary bladder in association with an IUD to illustrate the need to consider this infection in the differential diagnosis of bladder masses. <h3>Report of a Case</h3> A 36-year-old woman had a three-month history of cramping right-lower quadrant pain that intensified on urination. She denied burning with urination or urinary urgency. The results of a pelvic examination showed an enlarged irregular uterus of six to eight weeks' size with a contiguous 4×5-cm mass at
THE PHYSICIAN AND THE FOURTH.
Journal: JAMA (1905)

The Fourth of July has come and gone, half a hundred persons are dead and thousands injured and the count is not completed.<sup>1</sup>As usual, the accidents are in two classes, the immediate and the remote—in other words, the direct injuries from the explosives and the tetanus that develops later. The former are usually large wounds, the latter small and comparatively insignificant. On the other hand, the deaths caused by the former variety are few compared with those caused by the complications of tetanus in the latter. The physician's responsibility is also very different in the two classes. In the first—aside from the prompt and thorough care that the nearest medical man is expected to give in any accidental injury regardless of its relation to the Fourth—the physician's responsibility is that of any citizen in securing restrictive laws and their enforcement, and that of any other parent, adult or
Drug Use in America: Problem in Perspective. The Technical Papers of the Second Report of the National Commission on Marihuana and Drug Abuse. Appendix, 4 vols. Vol. I: Patterns and Consequences of Drug Use; vol. II: Sodal Responses to Drug Use; vol. III: The Legal System and Drog Control; vol. IV: Treatment and Rehabilitation. <i>Washington. D.C.. U.S. Government Printing Office, 1973, 1243 pp., $11.85 (paper); 781 pp., $6.15 (paper); 963 pp., $7.40 (paper); 863 pp., $7.45 (paper).</i>
Authors: None F.J.B.
Journal: American Journal of Psychiatry (1974)
Tornado Watch
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Council on drugs. List No. 75. New names
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer antigens
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1945)

BRITISHparents.Nevertheless, it is a great deal easier to theorize about allergy than to cure it, and, while there can be no doubt that inhibitory forces exist within the organism which can check the appearance of allergy in an individual who has inherited the tendency, there is no evidence that we can direct these forces in such a way, for example, as to prevent the appearance of infantile eczema in the offspring of allergic parents.It may therefore be most practical in the long run to concentrate on the factor of protein sensitization and try to render the home environment free from the common allergens-dusts and moulds.Unsightly Bursa Q.-Is there any curative treatment for the pads of fat or bursae which appear round the external malleoli of middle-aged women?They are not painful but very unsightly.
Sixteenth annual meeting of the European Working Group for Cystic Fibrosis
Journal: Thorax (1990)

The 16th annual meeting of the European Working Group for Cystic Fibrosis was held in Prague in June 1989.There were 400 delegates from Europe, the United States, Canada, and Australia.Keynote lectures reviewed the immunology of Pseudomonas aeruginosa infection, the evaluation of anti- biotic treatment in such infections, the im- portance of gastrointestinal function in cystic fibrosis, heart-lung transplantation, and recent advances in the identification of the cystic fibrosis gene.Spoken paper and poster sessions devoted to specific topics were also held.
Erratum
Authors: R. Qazi
Journal: JNCI Journal of the National Cancer Institute (1989)

Dr. Raman Qazi regrets to inform the readers of two errors in the tables of his report (J Natl Cancer Inst 1988;80:1486–1488). In table 1, the doses of DDTC should be 75 and 150 mg/kg, and in table 2, the unit for AUC should be mM - min.
Erratum for the Research Article: “An analysis of IL-36 signature genes and individuals with <i>IL1RL2</i> knockout mutations validates IL-36 as a psoriasis therapeutic target” by S. K. Mahil, M. Catapano, P. Di Meglio, N. Dand, H. Ahlfors, I. M. Carr, C. H. Smith, R. C. Trembath, M. Peakman, J. Wright, F. D. Ciccarelli, J. N. Barker, F. Capon
Journal: Science Translational Medicine (2017)
Adjuvant clodronate treatment improves the overall survival of primary breast cancer patients with micrometastases to bone marrow - a longtime follow-up
Authors: A. Jaschke, G. Bastert, E. F. Solomayer, S. Costa, F. Schuetz, I. J. Diel
Journal: Journal of Clinical Oncology (2004)

529 Background: The detection of micrometastases in bone marrow (BM) of primary breast cancer (BC) patients is an important independent prognostic factor. The presence of these cells goes along with a worse prognosis. However up to now only a few oncological centers take any therapeutical consequence from this diagnostical procedure since it was shown that even cytostatic therapies only have a limited impact on the overall survival of these patients. However we have reported previously that a postoperative treatment with clodronate led to an improvement of disease-free- and overall-survival in comparison to not treated primary BC patients with detected micrometastasis in BM (Diel et al, N Engl J Med 1997). Patients: 150 patients were treated with clodronate p.o. over a minimum of one year, 150 were not treated (9 dropouts). The stage and adjuvant therapy of the disease was not significant different between both groups. The follow up after five years showed a reduced incidence of osseous and visceral metastases in the clodronate-treated group which led to a significant better disease-free- as well as overall survival (p<0.001). These data were confirmed by a large randomised study of Powles et al. Results: This re-analysis has a follow up time of 103±12 months. We were able to reevaluate 290 of the original 309 patients. Incidence of osseous and visceral metastases is similar in both groups. Although we are not able to see a significant advantage regarding the disease-free survival any more there is still a significant better overall-survival for the clodronate-treated group (p<0.01) since 39% of the not-treated group died due to the cancer disease. Conclusion: Adjuvant clodronate therapy prolongs breast cancer patients' survival. The time period of treatment should be evaluated in further studies. No significant financial relationships to disclose.