POS1528-HPR FACTORS ASSOCIATED WITH FRAILTY STATUS IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS
Authors: Ö. Öztürk, Ö. Feyzioğlu
Journal: Annals of the Rheumatic Diseases (2022)

Background Frailty is characterized by increased fatigue and vulnerability which leads to adverse health outcomes. Recent studies have reported the increased prevalence of frailty in various rheumatological diseases regardless of age. However, information about the prevalence of frailty in patients with axial spondyloarthritis (axSpA) is limited. Objectives This study aims to determine prevalence of frailty and its assocaited factors in patients with axial spondyloarthritis (axSpA). Methods In this monocentric cross-sectional study 50 patients (26 women) with axSpA aged between 40 to 65 were included. Frailty status was determined using Kihon checklist. Patients were groups as pre-frail, frail and robust according to the Kihon Checklist and &lt;4 was accepted as robust, ≥4 pre-frail, 8≥ frail. Nutritional status, disease activity, functional level and quality of life were assessed using Mini Nutritional Assessment (MNA), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankilozan Spondylitis Functional Index (BASFI), Ankylosing Spondylitis Quality of Life Questionnaire (ASQoL) respectively. Analysis of variance and multivariate linear regression analyses were used to assess group differences and factors associated with frailty status. Results The mean age of the patients was 51.78±6.77, the mean disease duration was 7.8±8.41 years, the mean body mass index was 29.98 ±4.72 kg/m 2 . Twenty-one patients were classified as frail, 16 was pre-frail and 13 was robust. Compared to robust patients, pre-frail and frail individuals had significantly higher BASFI, BASDAI and ASQoL scores. There was a significant high correlation between the Kihon chekclist score and worse BASFI (r=0.62, p&lt;0.001), BASDAI (0.69, p&lt;0.001), ASQoL scores (0.73, p&lt;0.001). Poor nutritional status was moderately correlated with frailty index score (r=-0.53, p&lt;0.001). In multivariable linear regression analysis, nutrition status and level of quality of life were independently associated with frailty index score (p&lt;0.001). Figure 1. Percentages of patients according to their frailty status. Table 1. Comparison of patients according to their frailty status Robust (n= 13) Pre-frail (n=16) Frail (n=21) P 1 P 2 P 3 Age (years) 53.84±7.27 49.75±6.22 52.04±6.74 .24 .73 .56 Sex, women/men (n) 2/11 10/6 14/7 - - - BMI (kg/m 2 ) 27.86±5.61 28.31±3.15 30.19±5.07 .96 .35 .46 BASDAI 2.39±1.81 4.83±1.60 5.93±1.83 .00 .00 .15 BASFI 1.96±2.01 2.87±2.10 5.41±2.19 .48 .00 .00 ASQoL 4.23±3.94 7.75±4.76 12.61±4.22 .08 .00 .00 Mini Nutritional Assessment 25.61±1.47 24.59±2.13 23.59±2.16 .36 .01 .29 BMI; body mass index, BASDAI; Bath Ankylosing Spondylitis Disease Activity Index, BASFI; Bath Ankilozan Spondylitis Functional Index, ASQoL; Ankylosing Spondylitis Quality of Life Questionnaire. P 1 ; P value between robust and pre-frail individuals, P 2 ; P value between robust and frail individuals, P3; P value between robust and frail individuals. Conclusion Frailty or pre-frailty is common in patients with axSpA and the main factors associated with frailty status were poor nutritional status and level of quality of life. Since it is a reversible condition, identifying the frailty status and its associated factors may help to prevent further decline in functional level and to design appropriate treatment interventions. Further studies are needed to determine frailty prevalence and its predictors in patients with axSpA. References [1]Trujillo et al. Arthritis Rheumatol, 2019 [2]Lieber et al. ACR Open Rheumatol, 2022. Disclosure of Interests None declared