AB0732 OUTCOMES OF PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY IN TAKAYASU ARTERITIS: A SINGLE CENTER EXPERIENCE
Authors: A. Cioltean, C. Pamfil, M. M. Tamas, L. Damian, S. Rednic
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Revascularization endovascular techniques have been used with success in Takayasu arteritis (TA), but relapses sometimes appear. (1) There is much debate regarding optimal management and outcomes of patients who underwent these procedures. (2,3) <h3>Objectives</h3> The aim of the study was to investigate the long-term efficacy of percutaneous transluminal angioplasty (PTA) in patients with TA from a Romanian tertiary rheumatology center and factors that might influence it. <h3>Methods</h3> Data from clinical charts of patients with a diagnosis of TA established in the last 15 years who underwent interventional revascularization procedures were retrospectively studied. Symptoms, laboratory investigation results, data about treatment and outcome were analyzed at baseline and follow-up. <h3>Results</h3> There were 11 interventions of PTA in 6 patients with a diagnosis of TAK, all of them in women. The mean follow-up period was 59 months. Cardiologists were the ones who diagnosed the disease in 83% of the patients included. The mean delay in diagnosis was 74 months, while the biggest delay was of 242 months. Hypertension was the first sign of disease in 3 of the patients, while the rest complained of limb claudication (2 patients) and acute limb ischemia phenomenon (1 patient). The average disease duration until PTA was 65 months and most of them were done at the time of diagnosis (54%). PTA was performed while the disease was active in 100% of cases and biological inflammatory syndrome was present in 45% of cases. Symptoms relief was seen in all patients. Restenosis was seen in 3 cases – two of them in patients with lack of treatment adherence and one in a patient who wasn't given immunosuppression (due to delay in diagnosis). Restenosis was experienced 52 months after PTA, on average. Symptoms included relapse of limb claudication in 2 patients and hypertension and renal failure in a patient with renal artery restenosis. Inflammatory markers were raised in two cases. Clinical improvement was seen in all the patients after reintervention. <h3>Conclusion</h3> PTA is a valuable intervention in TA patients that significantly improves clinical symptoms. Relapses may appear especially in patients with deficient immunosuppression, and they may need revascularization interventions. <h3>References</h3> [1]Diao Y, Yan S, Premaratne S, Chen Y, Tian X, Chen Z et al. Surgery and Endovascular Management in Patients With Takayasu's Arteritis: A Ten-Year Retrospective Study. Ann Vasc Surg. 2020; 63:34-44. [2]Jung JH, Lee YH, Song GG, Jeong HS, Kim JH, Choi SJ. Endovascular Versus Open Surgical Intervention in Patients with Takayasu's Arteritis: A Meta-analysis. Eur J Vasc Endovasc Surg. 2018; 55(6):888-99. [3]Perera AH, Youngstein T, Gibbs RG, Jackson JE, Wolfe JH, Mason JC. Optimizing the outcome of vascular intervention for Takayasu arteritis. Br J Surg. 2014; 101(2):43-50. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.