tbuckley/cabot-search huggingface dataset:
Prevention of Benzene-Induced Myelotoxicity by Nonsteroidal Anti-Inflammatory Drugs
Authors: George F. Kalf, Michael J. Schlosser, John F. Renz, Suzanne J. Pirozzi
Journal: Environmental Health Perspectives (1989)

Benzene affects hematopoietic progenitor cells leading to bone marrow depression and genotoxic effects such as micronucleus formation. Progenitor cell proliferation and differentiation are inhibited by prostaglandins produced by macrophages. Administration of benzene to DBA/2 or C57BL/6 mice caused a dose-dependent bone marrow depression and a significant increase in marrow prostaglandin E level and both were prevented by the coadministration of indomethacin and other inhibitors of the cyclooxygenase component of prostaglandin H synthase. Levels of benzene that decreased bone marrow cellularity also caused genotoxic effects measured as increased micronucleated polychromatic erythrocytes in peripheral blood, which was also prevented by the coadministration of indomethacin. These results suggest a possible role for prostaglandin synthase in benzene myelotoxicity; a mechanism by which this might occur is presented.
Basic Pathology
Authors: Robert D. Coye
Journal: JAMA (1972)

Reading pathology used to be fun. Boyd's text (5th edition, 1947) was, while not a pocket book, readily transportable, and it could be read through in one semester with great enjoyment. For example, speaking of lymphocyte function, he quoted from Rich: "... they have the appearance of phlegmatic spectators passively watching the turbulent activities of the phagocytes." He went on to state that "there is now evidence to suggest that lymphocytes are the cells which produce the antibodies..." Since then we have learned much about lymphocytes. Unfortunately, authors of most new texts have written it all down with ponderous pedantry. Texts now routinely weigh 3,500 gm. Students have become bored and irritated. Now comes Robbins and Angell's<i>Basic Pathology</i>which is transportable (1,580 gm on our autopsy room scale), written with a very reasonable selection of general and special pathology subject material and with a good deal of insight into what
Refractory pancreatitis associated with graft‐versus‐host disease in Fanconi anemia
Authors: Masuji Yamamoto, Yoshimi Hiraumi, Noriko Ichimura, Fumiko Ohtsuki, Makiko Nakagawa, Yoshitoshi Ohtsuka, Yoshiaki Tsujino, Aiichiro Tanaka, Takashi Kamiya, Hiroyoshi Wada
Journal: American Journal of Hematology (1996)
Evaluation of Metaxalone
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contents
Authors: C.-F Huang, C.-Y Dai, M.-L Yeh, C.-I Huang, C.-M Tai, M.-H Hsieh, P.-C Liang, Y.-H Lin, M.-Y Hsieh, H.-L Yang, J.-F Huang, Z.-Y Lin, S.-C Chen, M.-L Yu, W.-L Chuang, Y.-H Hsu, C.-H Muo, C.-Y Liu, W.-C Tsai, C.-C Hsu, F.-C Sung, C.-H Kao, M.-F Yuen, S Ahn, K Lee, S Um, M Cho, S Yoon, J.-W Lee, N Park, Y.-O Kweon, J Sohn, J.-A Kim, C.-L Lai, K.-H Han, K Agarwal, S Fung, T Nguyen, W Cheng, E Sicard, S Ryder, J Flaherty, E Lawson, S Zhao, G Subramanian, J Mchutchison, E Gane, G Foster, L.-T Lin, C.-Y Chung, W.-C Hsu, S.-P Chang, T.-C Hung, J Shields, R Russell, C.-C Lin, C.-F Li, M.-H Yen, D Tyrrell, C Richardson, A Galbois, N Bige, C Pichereau, P.-Y Boe ¨lle, J.-L Baudel, S Bourcier, E Maury, B Guidet, H Ait-Oufella, S Han, S Ha, C.-K Park, J.-W Joh, C Kwon, G Kwon, G Kim, W Gwak, J Jeong, G Mandili, E Alchera, S Merlin, C Imarisio, B Chandrashekar, C Riganti, A Bianchi, F Novelli, A Follenzi, R Carini, M Baxter, S Withey, S Harrison, C.-P Segeritz, F Zhang, R Atkinson-Dell, C Rowe, D Gerrard, R Sison-Young, R Jenkins, J Henry, A Berry, L Mohamet, M Best, S Fenwick, H Malik, N Kitteringham, C Goldring, K Hanley, L Vallier, N Hanley, Y Liu, M Shao, Y Wu, C Yan, S Jiang, J Liu, J Dai, L Yang, J Li, W Jia, L Rui, M Healy, J Chow, F Byrne, D Breen, N Leitinger, C Lackner, S Caldwell, K Hoehn
Journal: Journal of Hepatology (2015)
SANITARY PROGRESS IN THE PHILIPPINES.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Letter: The role of arterial baroreceptors in mediating the cardiovascular response to a cardiac glycoside in conscious dogs.
Authors: R A Gillis, J A Quest
Journal: Circulation Research (1976)

The Role of Arterial Baroreceptors in Mediating the Cardiovascular Response to a Cardiac Clycoside in Conscious DogsThe study of McRitchie and Vatner (Circ.Res.38: 321, 1976) raises some questions regarding a possible important effect of ouabain to sensitize baroreceptors.Based on their data, they concluded that "cardiac glycosides do not exert a major action in sensitizing the arterial baroreceptors."They base their viewpoint on data obtained with ouabain administered to animals with and without sectioned carotid sinus and aortic nerves, and also on comparable data obtained with methoxamine.The pressor effect of both these agents was enhanced threefold by denervating the reflexes.They reasoned that if sensitization of baroreceptors was important in the response to ouabain "a greater difference in arterial pressure response should have been observed in -response to ouabain than tamethoxamine, because methoxamine is not known to exert a direct effect on the arterial baroreceptors."This is in contrast with our previous results in decerebrate unanesthetized cats wherein animals with cardiovascular reflexes denervated exhibited a greater difference in arterial pressure response to ouabain than to norepinephrine (Gillis et al., J. Pharmacol.Exp.Ther.170: 294, 1969).One difference between our experiments and those described in the present study is that, in addition to carotid sinus and aortic arch nerves being sectioned, afferent vagal nerves were also sectioned in our study.This was done because digitalis had been shown to have important actions on cardiac sensory receptors (Kido, Kyushu
Surgical treatment satisfaction among women with breast cancer: The role of preferences regarding shared decision making
Authors: P. M. Lantz, N. K. Janz, A. Fagerlin, M. Mujahid, B. Salem, S. J. Katz
Journal: Journal of Clinical Oncology (2004)

6033 Background: Although shared decision-making for surgical treatment of breast cancer is promoted as ideal, patient preferences for level of involvement may vary. We used data from a population-based sample of breast cancer patients to examine the relationship between decision context for surgical treatment and two key satisfaction outcomes. Methods: Study subjects were breast cancer patients reported to Detroit and Los Angeles SEER registries in 2002. All DCIS patients and a 20% random sample with non-metastatic invasive disease were mailed a questionnaire shortly after diagnosis (n=1,489; response rate 74.3%). Logistic regression was used to estimate the odds of having low satisfaction on validated scales for two dimensions of satisfaction: a) surgery received; and b) the process by which the surgery decision was made. Models included controls for age, race, stage, preferences regarding shared decision making, and the degree to which this preference was achieved. Results: 37.9% of women reported the surgery decision was shared, 21.1% that it was primarily made by the surgeon, and 41.0% that it was primarily made by themselves. Compared with how they wanted to make the decision, 65.1% experienced the amount of participation preferred while 12.5% had less and 22.4% had more. The strongest predictor of low satisfaction on both dimensions was incongruence between the amount of participation preferred and experienced. For example, the odds of having low satisfaction with the surgical outcome were 2.7 (p<.001) for those with less participation than preferred, and 1.4 (p<.05) for those with more than preferred. Women who received mastectomy were just as satisfied on both dimensions as those with lumpectomy. African American women had significantly lower levels of satisfaction than other women (p<.01). Conclusions: A salient factor associated with two important dimensions of satisfaction is the match between patient preferences and the actual degree of participation in the surgery decision. Thus, increased promotion of shared decision making will not automatically lead to increased satisfaction among all breast cancer patients. No significant financial relationships to disclose.
Worsening of quality of life (QoL), cognitive functions (CF) and psychological status (PSY) can predict radiologic progressive disease (RPD) in glioblastoma (GBM) patients (PTS) treated with radiation therapy (RT) and temozolomide (TMZ): a mono-institutional prospective study
Authors: E. Bergo, G. Lombardi, P. Del Bianco, S. Dal Pos, F. Berti, L. Bellu, A. Pambuku, V. Zagonel
Journal: Annals of Oncology (2017)
Epidemiology of cervical cancer: tour d'horizon
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Corresponding Author Address
Journal: JAMA Oncology (2016)

Nicholas D. James, BSc, MBBS, PhD, FRCP, FRCR; Melissa R. Spears, MSc, BSc; Noel W. Clarke, MBBS, FRCS(Eng), ChM(Manch), FRCS(Urol); David P. Dearnaley, MA, MB, BChir, MD, FRCP, FRC; Malcolm D. Mason, MD, FRCP, FRCR, FSB; Christopher C. Parker, BA, BM, BChir, MD; Alastair W. S. Ritchie, MD, FRCSEd; J. Martin Russell, BSc, MB, ChB, MRCP(UK), FRCR, FRCPSG; Francesca Schiavone, PhD; Gerhardt Attard, MD, PhD; Johann S. de Bono, MBChB, MSc, PhD, FRCP, FMedSci; Alison Birtle, MB, BS, MRCP, FRCR, MD; Daniel S. Engeler, MD; Tony Elliott, BSc, MSc, PhD, MBChB, MRCP, FRCR; David Matheson, BSc, PGCE, DipEd, MEd, PhD, FRSA, FHEA; Joe O’Sullivan, MD, FRCR, FFRRCSI, FRCPI; Delia Pudney, MBChB; Narayanan Srihari, MB, BS; Jan Wallace, MB, ChB, FRCR; Jim Barber, MA, DM, FRCR, MRCP; Isabel Syndikus, MD; Mahesh K. B. Parmar, DPhil, MSc, BSc; Matthew R. Sydes, MSc, CStat; for the STAMPEDE Investigators
Marginal Degeneration of Cornea with Perforation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A PERNICIOUS OSSEOUS DISEASE (LYMPHADENIA OSSIUM.)
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Surgery (2019)

Cricoid Pressure and Rapid Sequence Induction of Anesthesia 9The use of cricoid pressure during rapid sequence induction of anesthesia remains controversial.In a double-blind, noninferiority randomized clinical trial of 3472 patients undergoing anesthesia with rapid sequence induction, Birenbaum and colleagues demonstrated that the incidence of pulmonary aspiration was rare (0.5%), and noninferiority to the sham procedure was not found.Other secondary end points were also not significant, except those suggesting increased difficulties in tracheal intubation.
Patient participation in a hypertension control program. Hypertension Detection and Follow-up Program Cooperative Group
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neurology/ Internal Medicine
Authors: Donald J. Dalessio
Journal: JAMA (1980)

Disorders of the nervous system encompass broad categories of disease. It is impossible to review the clinical progress accomplished during the last year in a brief essay such as this. What follows are a few selected topics I have found to be unusually interesting, related to internal medicine, and liable to be of clinical importance to a general physician audience. <h3>Toxic Pseudotumor Cerebri</h3> Pseudotumor cerebri is characterized by headache, papilledema, and increased intracranial pressure, in the absence of an intracranial mass. Although the alternative term "benign intracranial hypertension" has also been used, because spontaneous recovery generally occurs, the process is not always benign; occasionally, visual acuity may be severely damaged. Pseudotumor cerebri has many presumed causes. In only a few of them, however, is the mechanism of increase in intracranial pressure obvious. There may be increased venous pressure with a disproportion in the rate of formation and absorption of CSF
T-helper 1-type immunity to trophoblast in women with recurrent spontaneous abortion
Authors: J. A. Hill
Journal: JAMA (1995)

<h3>Objective.</h3> —To test the hypothesis that peripheral blood mononuclear cells in women with unexplained recurrent abortion (URA) produce T-helper 1 (T<sub>H</sub>1)—type cytokines in response to trophoblast antigens. <h3>Design.</h3> —Cohort study. <h3>Setting.</h3> —Medical center. <h3>Participants.</h3> —A total of 244 women with URA, 13 reproductively normal parous control women, and 10 men. <h3>Main Outcome Measures.</h3> —Supernatants from trophoblast-activated peripheral blood mononuclear cells from all participants were tested for toxic effects on mouse embryos and by enzyme-linked immunosorbent assay (ELISA) for interferon gamma (IFN-γ). Supernatants from 20 URA patients with embryotoxic activity and IFN-γ, 13 reproductively normal parous women, and 10 men were further tested by ELISA for other T<sub>H</sub>1-type cytokines (interleukin-2 [IL-2], tumor necrosis factor—β [TNF-β]), T<sub>H</sub>2-type cytokines (IL-4, IL-10), and TNF-α. <h3>Results.</h3> —Embryotoxic activity was detected in supernatants from 160 of 244 URA patients and in none of the controls. Interferon gamma was detected in supernatants from 125 of 244 URA patients and was significantly associated with embryotoxicity (121 of 160 supernatants with embryotoxicity vs four of 84 supernatants without embryotoxicity [<i>P</i>&lt;.001]). Of 20 supernatants from patients chosen for further study, all were positive for TNF-α, 17 for TNF-β, two for IL-10, and one for IL-4. No cytokines were detected in supernatants from unstimulated or red blood cell membrane—activated cells of women with URA. In contrast, trophoblast-activated lymphocyte supernatants from reproductively normal women and men neither were embryotoxic nor contained T<sub>H</sub>1-type cytokines, but most contained the T<sub>H</sub>2-type cytokine IL-10. Three supernatants from reproductively normal women also contained IL-4. <h3>Conclusion.</h3> —Whereas T<sub>H</sub>1-type immunity to trophoblast is associated with URA and may play a role in reproductive failure, T<sub>H</sub>2-type immunity may be a natural response to trophoblast contributing to successful pregnancy. (<i>JAMA</i>. 1995;273:1933-1936)
Plastic Surgery of the Orbit.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute Otitis Media.
Authors: J. O. Malsbury
Journal: JAMA (1897)

Peru, Ind.,March 16,1897. <h3>To the Editor:</h3> —In my comments on the treatment of "acute otitis media," in the last issue of theJournal, March 13, the clause reading "which would have<i>burned</i>the moisture, etc., should have read: which would have<i>lessened</i>the moisture, etc. In the same issue Dr. W. H. Daly of Pittsburg, Pa., gives instructions about blowing the nose, following the use of the nasal-douche, etc. "To blow one side of the nose only at a time." I would suggest that the only efficient way of blowing the nose after the use of the douche, etc., as well as other times, is to simply<i>blow forcibly without holding either side</i>, on the same principle that you expectorate without holding the mouth. To be convinced of the truthfulness of this statement, you have only to follow out the above suggestion.