tbuckley/cabot-search huggingface dataset:
Handbook of Electrotherapeutics.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Pharmacology and Therapeutics . By Arthur R. Cushny, M.D., LL.D., F.R.S. Twelfth edition, thoroughly revised by C. W. Edmunds, M.D., and J. A. Gunn, M.D., D.Sc., F.R.C.P. 8°, cloth, 852 pp., with 66 illustrations. Philadelphia: Lea and Febiger, 1940. $6.50.
Journal: New England Journal of Medicine (1941)
The Care of the Nose, Throat, and Ear.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
B.M.A. Scientific Meeting, Southampton: President's Opening Address
Journal: BMJ (1972)

opened the meeting with his presidential address on "The Development of Thoracic Surgery-an Exercise in Collaboration."He began by expressing his appreciation of the honour the Association had bestowed on him.He was particularly pleased to speak in Southampton, a city famed for its industry, its central position in the world of maritime transport, and for its young and thriving university.The new Medical School with its dynamic staff was an in- stitution from which many new ideas and activities could be expected, and Sir Thomas assured his audience of his personal con- tinuing interest in its evolution.He then took up the theme of his lecture -a review of the past three decades and how the pattern of medicine had altered in that time.Looking back, the most significant feature in that period had been the frag- mentation of medicine, with the development of more and more specialties and the formation of new colleges.No-one could deny the value of a specialty forging ahead in its own particular field, but as surgeons and physicians tended to know more and more about less and less, there was the danger of medicine exploding into fragments that would not easily be put together.By collaboration with other disciplines, he went on, some of the problems that beset extreme specialization could be avoided.He had al- ways taught that thoracic surgery was not a specialty-it was essentially a general sur- gical and medical subject in a regional field, and dealt with all systems of the body that came within the confines of the thorax.
A Study in Post-Flexner Survival
Authors: W. Curtis Worthington
Journal: JAMA (1991)

The Flexner report of 1910 resulted in the closing of many marginal medical schools and opened a new era in medical education in the United States. Caught in Abraham Flexner's net were several old schools with long histories and, as he said, "traditions and a certain present dignity" that lacked the minimum resources needed to meet the standards of the Council on Medical Education of the American Medical Association. One example was the Medical College of the State of South Carolina. It was consigned to oblivion in Flexner's plan, but survived. Dean Robert Wilson, MD, in his efforts to save his school, turned politician, enlisted the aid of the state's highly controversial governor, and initiated an effective lobbying campaign in the state legislature. The Council on Medical Education became involved unofficially in the person of its secretary, Nathan P. Colwell, MD. His presence in South Carolina was turned to advantage by Wilson and others and contributed substantially to the success of their efforts. (<i>JAMA</i>. 1991;266:981-984)
Epidemiology of Cancer from Exposure to Arylamines
Authors: Paolo Vineis
Journal: Environmental Health Perspectives (1994)

Occupational exposure to arylamines such as benzidine, 2-naphthylamine, and 4-aminobiphenyl is associated with exceptionally elevated risks of bladder cancer (up to 100-fold or more).In one plant, all 15 workers involved in distilling naphthylamine developed bladder cancer, suggesting that for high levels of exposure to potent carcinogens individual susceptibility is irrelevant.More recently, exposure to other arylamines also has been suggested to increase the risk of bladder cancer in humans.In addition, cohort and case-control studies suggest that several job titles or exposures may involve elevated risks of bladder cancer.Some of these jobs or exposures (such as in the aluminum industry) are associated with exposure to arylamines.Arylamines are found also in tobacco smoke, and different sources of evidence suggest that they can explain the risk of bladder cancer, which has been shown clearly in smokers.Epidemiologic analyses of timing of exposure in workers occupationally exposed to arylamines or in air-cured tobacco smokers suggest that arylamines exert both an early-and a late-stage activity, compatible with a two-mutation theory of bladder carcinogenesis.
The Ear and Its Diseases.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tricyclic Antidepressants
Authors: Alfred Coodley
Journal: JAMA (1979)

<h3>To the Editor.—</h3> I fully agree with Neal R. Cutler, MD, and Jon F. Heiser, MD (240:2264, 1978), in their article "The Tricyclic Antidepressants," except for one point regarding initial dosage. It has been my experience that one should start at a dosage equivalent to not more than 50 mg/day of imipramine hydrochloride. This is certainly true if 25 mg twice a day is administered, because a number of patients will become sedated and feel as if their depression has been intensified. Actually, I initiate therapy at 25 mg/day to make certain that side effects are absolutely minimal and also to give me a concrete idea as to how this particular patient relates to the taking of medication. After one to two days, I increase the dosage to 50 mg/day for one to two days and then raise it to the 75 mg/day that Cutler and Heiser recommended. The dosage
Dengue Fever in the United States
Authors: Michael D. Malison
Journal: JAMA (1983)

In the United States during 1981, fourteen state health departments reported a total of 44 imported cases of dengue fever. Most originated in the Caribbean, where dengue type 4 has reached pandemic proportions. Because the mosquito vector for dengue is abundant throughout the southeast and imported cases continue to occur, the possibility exists for indigenous dengue transmission. We report a cluster of imported dengue type 1 cases in Florida, discuss the clinical, epidemiologic, and public health aspects of the disease, and make recommendations as to how clinicians can assist public health officials in minimizing the risk of indigenous dengue transmission in the United States. (<i>JAMA</i>1983;249:496-500)
Nivolumab May Work as First-Line NSCLC Therapy
Journal: Cancer Discovery (2016)

Abstract The first trial of nivolumab as a first-line therapy for non–small cell lung cancer suggests that the drug can improve survival. Adding some platinum-doublet chemotherapy combinations did not further increase this effect, although the median overall survival wasn't reached for paclitaxel and carboplatin. Adding chemotherapy may increase the immunotherapy's toxicity.
T-Lymphocyte Recognition of Antigen in Association with Gene Products of the Major Histocompatibility Complex
Authors: R. Schwartz
Journal: Annual Review of Immunology (1985)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
Ketosis and metabolic alkalosis in a patient with diabetes
Authors: G. M. Roggin
Journal: JAMA (1970)

Diabetic ketosis with clinical signs of acidosis was observed in a patient with known diabetes and tuberculosis. Studies obtained on admission to the hospital led to the diagnosis of metabolic alkalosis. This condition was attributed to prolonged vomiting secondary to antituberculous treatment. Management of the alkalosis with large amounts of fluids containing potassium chloride, and correction of the diabetic hyperketonemia and hyperglycemia with insulin were effective. The determination of blood-gas levels in severely ketotic patients is essential for the detection of these combined metabolic disturbances and, indeed, may be lifesaving.
Abstract 1189: Revisiting immune exhaustion in Hodgkin’s lymphoma
Authors: Anthony R. Colombo, Monirath Hav, Erik Gerdtsson, Jose Bisnesto-Villasboas, Stephen Ansell, James Hicks, Peter Kuhn, Akil Merchant
Journal: Cancer Research (2019)

Abstract Clinical successes with immune check-point blockers have demonstrated the potency of the immune system in controlling cancers, most strikingly in Hodgkin lymphoma (HL), where overall response rates to PD1/L1 inhibitors approach 90%. Complete or durable responses, however, are uncommon, therefore targeting the PD1/L1 axis alone is not sufficient. Recent work analyzing the spatial arrangement of PD1 and PDL1 expressing cells has given us new insight into the mechanism of action of PD1/L1 inhibitors, however this work limited itself to studying a single check point marker on a subset of cells. We hypothesize that comprehensive profiling of the frequency and spatial arrangement of immune cells in the Hodgkin lymphoma tumor immune microenvironment (TME) will provide new insights into the mechanism of checkpoint blockers and identify novel targets for immune therapy. Until now, multiparameter spatial analysis of the immune microenvironment was limited by technical challenges. Flow and mass cytometry are able to identify immune subsets of interest but spatial information is lost. Multiplex tissue imaging methods are limited to 6-8 simultaneous markers and cannot capture the full complexity of the immune phenotypes. The Fluidigm Hyperion imaging mass cytometry (IMC) system combines a CyTOF mass cytometer with a laser ablation system allowing for 40+ parameter simultaneous immunophenotyping on a single slide of FFPE tissue, with sub-cellular resolution. We have developed a panel of 34 antibodies that allow for comprehensive characterization of CD4, CD8 and myeloid cells components in the TME of Hodgkin lymphoma using IMC. Here we report on our spatial analysis of TIM3 and LAG3 expressing CD4+ lymphocytes. Our data suggests LAG3+CD4+ and TIM3+CD4+ lymphocytes had shorter mean nearest distance to PDL1+Hodgkin Reed-Sternberg (HRS) cells upon comparison to PDL1- HRS cells (t-test, p=1.703e-08,p=1.126e-14). Future studies should explore multiple exhausted marker models that seeks to further understand the presence of simultaneous exhaustion signals in the niche environment. These data suggest that therapies that target TIM3 and/or LAG3 should be tested in Hodgkin Lymphoma and that spatial analysis of immune subsets by IMC should be explored as selective and pharmacodynamic biomarkers. Citation Format: Anthony R. Colombo, Monirath Hav, Erik Gerdtsson, Jose Bisnesto-Villasboas, Stephen Ansell, James Hicks, Peter Kuhn, Akil Merchant. Revisiting immune exhaustion in Hodgkin’s lymphoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1189.
Accreditation and the Supply of Physicians
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Weapon involvement and injury outcomes in family and intimate assaults
Authors: L. E. Saltzman
Journal: JAMA (1992)

<h3>Objective.</h3> —To compare the risk of death and the risk of nonfatal injury during firearm-associated family and intimate assaults (FIAs) with the risks during non-firearm-associated FIAs. <h3>Design.</h3> —Records review of police incident reports of FIAs that occurred in 1984. Victim outcomes (death, nonfatal injury, no injury) and weapon involvement were examined for incidents involving only one perpetrator. <h3>Setting.</h3> —City of Atlanta, Ga, within Fulton County. <h3>Participants.</h3> —Stratified sample (n=142) of victims of nonfatal FIAs, drawn from seven nonfatal crime categories, plus all fatal victims (n=23) of FIAs. <h3>Main Outcome Measures.</h3> —Risk of death (vs nonfatal injury or no injury) during FIAs involving firearms, relative to other types of weapons; risk of nonfatal injury (vs all other outcomes, including death) during FIAs involving firearms, relative to other types of weapons. <h3>Results.</h3> —Firearm-associated FIAs were 3.0 times (95% confidence interval, 0.9 to 10.0) more likely to result in death than FIAs involving knives or other cutting instruments and 23.4 times (95% confidence interval, 7.0 to 78.6) more likely to result in death than FIAs involving other weapons or bodily force. Overall, firearmassociated FIAs were 12.0 times (95% confidence interval, 4.6 to 31.5) more likely to result in death than non-firearm-associated FIAs. <h3>Conclusions.</h3> —Strategies for limiting the number of deaths and injuries resulting from FIAs include reducing the access of potential FIA assailants to firearms, modifying firearm lethality through redesign, and establishing programs for primary prevention of violence among intimates. (<i>JAMA</i>. 1992;267:3043-3047)
Rectal Approach to Neuropathology
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DANIEL LECLERC (1652-1728) MEDICAL HISTORIAN
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MISCELLANEOUS.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Advancing America's health
Authors: P. R. Lee
Journal: JAMA (1995)

In 1787, Thomas Jefferson wrote, "without health there is no happiness. An attention to health, then, should take the place of every other object." As the process of health system reform moves forward, attention and resources must be directed toward advancing America's health. To direct attention toward health, the US Public Health Service is developing strategies that: Restructure the health care system to focus on the health of populations. Define and strengthen the public health system. Ensure public health agencies and health care plans collaborate to respond to local community needs. Build infrastructure—information systems, research, workforce—to advance health. Realize responsible social policies. I call this fivefold strategy "reinventing public health." Although Congress did not enact comprehensive health system reform this year, the American health care system is experiencing profound change, particularly in the private sector. A major part of the health care system is moving away from
Tobacco-and-health courtroom drama continues
Authors: T. F. Kirn
Journal: JAMA (1988)

THE LATEST LAWSUIT seeking to hold some tobacco companies liable for smokers' ill health—in this case, for a death that followed more than four decades of smoking—is expected to go to the jury in a matter of days. When she was 16 years old, Rose Cipollone started smoking cigarettes. Cipollone ended up smoking about 1½ packs a day for almost 42 years, despite her husband's nagging and two attempts to quit. In 1981, she was diagnosed as having cancer. Later that year, the upper lobe of her right lung was removed. The rest of the lung was removed the following year and in 1983 surgeons excised her adrenal gland. She died in 1984, at age 59 years. Now, her widower, Antonio Cipollone of Lakehurst, NJ, is seeking unspecified damages from three cigarette companies—Liggett &amp; Meyers, Phillip Morris Companies, and Lorillard Inc— for his wife's death. He hired Mark Z. Edell,