tbuckley/cabot-search huggingface dataset:
SIR GEORGE MURRAY HUMPHRY (1820-1896)— CAMBRIDGE UNIVERSITY SURGEON
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Week
Journal: BMJ (1979)

The Week A personal view of current medicopolitical events I'm not sure which is worse: the weather, the strikes, or the media-initiated waves of doom and despondency that break over us morning, noon, and night.So, on the assumption that you don't want to read any more gloomy reports about, savage comments on, or "only" solutions for this country's persistent politicoindustrial masochism I will say no more than draw your attention to the Council's decision last week to say nothing at present (p 357).
List No. 78. New names
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Retrospective review of subsequent treatments (tx) for esophagogastric adenocarcinomas (EGA) refractory to FOLFOX.
Authors: Ciara Marie Kelly, Yelena Yuriy Janjigian, David Paul Kelsen, Marinela Capanu, Joanne F. Chou, David H. Ilson, Geoffrey Yuyat Ku
Journal: Journal of Clinical Oncology (2016)

e15556 Background: FOLFOX is a preferred 1st-line tx for advanced EGA. We sought to characterize outcomes on subsequent tx and to see if MSK-IMPACT, a 341-gene next generation sequencing (NGS) platform, increases tx options. Methods: We retrospectively identified patients (pts) with advanced, Her2-negative EGA treated with 1st-line FOLFOX between Jan 2012 to Dec 2014. Clinicopathologic, tx and outcome data were analyzed. Overall survival (OS) was calculated from start of FOLFOX using Kaplan-Meier methods. Landmark analysis was used to compare OS and response status. Results: 185 pts were identified. The majority were Caucasian (82%), male (76%), ECOG PS 1 (67%), with poorly differentiated histology (72%) and de novo metastatic disease (84%). Median age was 64 years. The disease-control rate (DCR, partial response + stable disease) of FOLFOX was 80% [95%CI: 74%-85%]; 19% were FOLFOX primary refractory (FR). Median time-to-progression (TTP) on FOLFOX was 7 and 2 months (mo) for FOLFOX sensitive (FS) and FR pts, respectively. There was a higher proportion of females (26% vs. 14%, P = 0.18), gastric (43% vs. 23%, P = 0.051) and moderately differentiated tumors (26% vs. 12%, p = 0.113) in the FS vs. FR group. Six mo survival from the landmark time of 2 mo after initiation of FOLFOX was 83% [95%CI: 76%-89%], and 38% [95%CI: 20%-56%] for FS and FR pts, respectively (p < 0.01). A similar proportion of FS and FR pts received 2nd-line tx (65% vs. 69%). The DCR was similar in both groups (31% vs 29%). 2nd-line tx included: irinotecan- (51%) and taxane-based regimens (32%) or a clinical trial (CT) (13%). The median TTP on 2nd-line tx was similar in FS and FR groups (2.5 vs 2 mo). Ramucirumab was given in 14% of 2nd line regimens. 3rd-line chemo use was similar in both groups (37% vs 31%) but the DCR was lower in FR patients (18% vs. 9%). 51 pts had IMPACT; 1 pt (2%) enrolled onto a genotyped-matched CT. 14 pts received immunotherapy; 1 FS Pt has ongoing complete response 1+ year. Conclusions: Surprisingly, FS and FR pts derive similar, marginal benefit from 2nd-line tx, emphasizing the appropriateness of CT options in this setting. NGS rarely expanded tx options. Updated and in-depth NGS data will be presented.
Emergency medicine
Authors: D. P. Sklar
Journal: JAMA (1994)

Emergency medicine, because of its broad, general scope of activity, adapted itself to meet the medical demands of a changing society. Access for all, 24-hour availability, primary care, critical care, social services, and care for indigent patients are but a few of the factors that have created the present emergency department environment. In 1993, several important issues—violence affecting patients and emergency care providers, the occurrence of natural disasters, the need to limit futile care in the prehospital and hospital environment, and the uncertainty surrounding health system reform—all changed the profile of emergency medicine in substantial ways. As the primary interface between the population and acute medical care, emergency medicine is at the forefront of the medical community's response to the nation's violence epidemic. Violence directed against men, women, and children, and even against physicians, nurses, and emergency medical technicians, has become an everyday part of the practice of emergency medicine.
Discussions
Journal: British Journal of Sports Medicine (1976)

CLARKE: Can you suggest any practical way under racing conditions for distinguishing between procaine and procaine penicillin?Obviously you cannot take a series of blood samples from a horse actually racing.TOBIN: No, I know no way on a single sample.BLAKE: It depends on how soon, following the administration of procaine penicillin, it is tested.We do have an electron capture method for penicillin G. and if procaine is present, we have to assume it was given as procaine penicillin, but the only realistic way is to take multiple blood samples, not realistic on a racetrack.TOBIN: If Blake finds a positive he would ask for another sample from that horse immediately.If it was procaine penicillin we would still expect to find it in the plasma, if it was procaine HCI it should be undetectable.MAYNARD: There are preparations which contain both procaine hydrochloride and procaine penicillin.TOBIN: What is the procaine HCI in the preparation for?It would seem to be pharmacologically unnecessary.ROBSON: The chief use of procaine in humans is that penicillin salts by themselves cause local pain that may be present for a period of several hours, and procaine was introduced as a local anaesthetic to prevent the injection mass being painful.TOBIN: I understood the reason is to delay absorption.JAGGARD: Have you done any work yet with azomycin?We have found that it will stay in the horse's urine for 3 to 4 days possibly because of buffers, lecithin and other ingredients in the formulation.
Persistence of platinum in semen of cisplatin-treated survivors of advanced testicular cancer.
Authors: Eoghan Ruadh Malone, Jeremy Howard Lewin, Susan Lau, Robert James Hamilton, Aaron Richard Hansen, Keith Jarvi, Wenjiang Zhang, Eric Xueyu Chen, Philippe L. Bedard
Journal: Journal of Clinical Oncology (2019)

519 Background: Even in patients (pts) with widely metastatic germ cell tumors cure rates are high with cisplatin based chemotherapy. Survivors of testicular cancer often have impaired gonadal function possibly related to chemotherapy. Most pts develop temporary azoospermia with recovery in about 50% after 2 years and 80% after 5 years. Platinum persists in blood in these pts, however, it is not known whether platinum also persists in semen. Methods: Pts who completed cisplatin &gt; 3 months previously were enrolled. Age, total cisplatin dose and date of completion of treatment were collected. A semen sample was collected from each patient for analysis to assess semen quality. A blood sample was collected to assess FSH/LH/testosterone/creatinine. Serum and semen platinum levels were measured using HPLC-tandem mass spectrometry. Results: Between 11/2017 and 09/2018, 9 pts (median age 32 years; range: 18-52) were enrolled to the study, all were treated with standard Bleomycin, Etoposide, Cisplatin regimen. Blood samples were collected from 7 pts, and semen samples from 4 pts. Median total cisplatin dose given was 658 mg (range: 570-780). Median serum platinum concentration was 0.395 ng/mL (range: 0.10-0.94) at a median of 10 months (range 4.5-13) post completion of treatment. Median semen platinum concentration was 1.06 ng/mL (range: 0.25-1.47) at a median of 10 months (range: 6-14) post completion of treatment. Semen platinum levels were associated with total cisplatin dose administered (Pearson correlation, r = 0.645) and time from completion of treatment (Pearson correlation, r = 0.386). In all 4 pts with matched samples, the semen platinum level was higher than the serum platinum level. Semen analysis showed 2 pts were azoospermic post treatment, 1 of these was also azoospermic prior to treatment; 1 pt had normal semen analysis post treatment and 1 had a low sperm count post treatment. Conclusions: This is the first study demonstrating that platinum persists in semen &gt; 6 months post completion of cisplatin-containing chemotherapy. Platinum levels are higher in semen than in blood following treatment. Our preliminary findings may have important implications for reproductive health of survivors of advanced testicular cancer.
VIEWS REGARDING IRON IN THERAPY
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nonpuerperal Galactorrhea
Authors: Craig J. Canfield, Robert W. Bates
Journal: New England Journal of Medicine (1965)

LACTATION not associated with childbirth has been described since antiquity.1 , 2 Although reported in association with a variety of conditions, it remains an unusual occurrence. Except for galactorrhea a common factor in all cases has not been found. Many patients have had proved or postulated abnormalities of the hypothalamic or pituitary region that have been thought to be caused by prolactin excess.2 , 3 Owing to difficulties in assaying this hormone, little information is available on prolactin secretion in these conditions.In the last eight years 17 patients with nonpuerperal galactorrhea have been seen at this hospital. The purpose of this report is . . .
Resuscitation Orders
Authors: Sallyann M. Bowman
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 December 1989Resuscitation OrdersSallyann M. Bowman, MDSallyann M. Bowman, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-12-1046_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: I read with interest the article by Dr. Wachter and colleagues (1) on housestaff decisions concerning do-not-resuscitate (DNR) orders for patients with different diseases and similar prognoses. I concur with all the conclusions but wish that their study had examined two other potential variables influencing the decision to approach a patient concerning a DNR order: namely, the attitude of the attending physician toward the disease entity and physicians' own fears concerning exposure to infection.Having supervised house officers in a major metropolitan teaching program for the last 9 years, I have observed that attending physicians hold great...Reference1. WachterLuceHearstLo RJNB. Decisions about resuscitation: inequities among patients with different diseases but similar prognoses. Ann Intern Med. 1989;111:525-32. LinkGoogle Scholar1. WachterLuceHearstLo RJNB. Decisions about resuscitation: inequities among patients with different diseases but similar prognoses. Ann Intern Med. 1989;111:525-32. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Sallyann M. Bowman, MDAffiliations: Hahnemann University Philadelphia, PA 19102-1192 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1989Volume 111, Issue 12Page: 1046-1046KeywordsDo not resuscitate ordersFearInfectious diseasesResuscitation ePublished: 1 December 2008 Issue Published: 15 December 1989 PDF downloadLoading ...
Periodic physician recredentialing
Journal: JAMA (1991)

<h3>To the Editor.—</h3> Gellhorn's<sup>1</sup>speculation that physician recredentialing and the assurance it would provide to the public might assist in medical malpractice tort reform is absurd. At present, physicians are subjected to strict licensing standards. In California, in addition to proof of medical school transcripts, original copy of diploma, certifying letter from the dean of the medical school, successful completion of FLEX (Federation Licensing Examination) or National Board examinations, and 1 year of supervised internship, the physicians are fingerprinted and computerized images are sent to local, state, and federal authorities, including the Department of Justice and the Federal Bureau of Investigation. Despite this, California faces a medical malpractice crisis. Recredentialing dodges true tort reform. Perhaps the attorneys should be "recredentialed." The bottom line for recredentialing of physicians should be improved patient care and/or decreased costs of patient care. However, no scientific study has been performed that demonstrates that periodic
Notes on Books
Journal: BMJ (1898)

THis small book deals only with certain points in the bacteri- ology, clinical aspects, and treatment of diphtheria during its acute stage; but some of the points raised are important, notably those relating to the diffusion of the bacillus through the body, the significance of its varieties, and the influence of the microbes associated with it.The authors are evidently inclined to make many exceptions to the commonly held view that the bacillus is confined to the local lesions, and that constitutional symptoms are the effects of the diffused toxins.Curiously enough, they succeeded in cultivating the bacillus from the medulla oblongata and pons more frequently than from any other organ except the lungs.This fact, they think, throws light on the pathology of diphtherial paralysis and the "bulbar accidents " so frequently met with.We confess we should like to have these observations confirmed, and to know that sections of the medulla showing the bacilli in situ had been studied by other pathologists.About the significance of the varieties of the bacillus we suppose there will be much difference for some time to come.The authors distrust all except the long variety, the original Klebs-Loeffier organism.We cannot, however, follow them with respect to their estimate of the part played by the asso- ciated microbes.It is probable that the innuence of these organisms in diphtheria is much exaggerated, and that no greater proof of this exaggeration is wanted than the mar- vellous results of the antitoxin treatment, which has been fre- quently found to cure cases such as are described in this book as typical of "associated diphtheria," and supposed, there- fore, not to be very amenable to the specific treatment.The book, though small, is very suggestive, and we wish that the authors, who possess wide clinical experience, had favoured us with more of their knowledge.
Most renal transplant recipients are not screened for skin cancer
Journal: BMJ (2001)

Pelvic floor exercises help prevent postnatal incontinenceAdvice and training in pelvic floor exercises and bladder control can reduce the incidence of persistent urinary incontinence after childbirth.Postnatal urinary incontinence affects around 30% of women and, without treatment, can persist for at least a year in two thirds of them.In a large randomised controlled trial of conservative management provided by nurses Glazener and colleagues (p 593) found that the risk of both urinary and faecal incontinence was reduced at 12 months after delivery.
Physician utilization disparities between the uninsured and insured. Comparisons of the chronically ill, acutely ill, and well nonelderly populations
Authors: C. Hafner-Eaton
Journal: JAMA (1993)

<h3>Background.</h3> —This study examines the associations between lack of health insurance coverage and physician utilization for the chronically ill, acutely ill, and well nonelderly populations in the United States. <h3>Methods.</h3> —Cross-sectional data from the 1989 National Health Interview Survey, conducted by the National Center for Health Statistics, were analyzed for the nonelderly population using a correlational, two-group design (N=102 055). Analytic models, using multiple logistic regression, were tested to predict the odds and likelihood of physician utilization for the uninsured and insured in the three subpopulations (ie, chronically ill, acutely ill, and well), controlling for health status, number of conditions, and geographic, sociodemographic, and economic factors. Disparities in utilization were then calculated between the uninsured and insured for each subpopulation. <h3>Results.</h3> —The nonelderly uninsured were consistently less likely than the insured to have received any health care within 12 months. Moreover, there were differential effects of being uninsured on utilization depending on whether an individual was chronically ill, acutely ill, or well. Whereas chronically ill and well uninsured persons were half as likely to have seen a physician as their insured counterparts (odds ratio, 0.50), acutely ill uninsured persons were almost two thirds as likely to receive physician care (odds ratio, 0.62). Thus, the disparity in physician utilization between the uninsured and insured was larger for the chronically ill and well than for the acutely ill; uninsured acutely ill were less likely to go without care. Of the three populations, those in the well population had average disparities with the largest magnitude (40%), compared with disparities of the chronically ill (20%) and acutely ill (10%). <h3>Conclusions.</h3> —These disparities represent large inequities in utilization of care by the uninsured, particularly for the chronically ill and well. Whether these disparities result from lower access or individual choice cannot be determined from this study. When viewed in light of other studies examining the impact of utilization on health status, these results provide support for the development of comprehensive health insurance packages with universal coverage and better inclusion of chronic and preventive care models in benefit packages. (<i>JAMA</i>. 1993;269:787-792)
Physicians and acquired immunodeficiency syndrome: a reply to patients
Authors: N. W. Dickey
Journal: JAMA (1989)

The article by Gerbert et al,<sup>1</sup>in this issue ofThe Journal, presents a number of opinions expressed by the public in response to a questionnaire. The article indicates that there is need for education of the public regarding the acquired immunodeficiency syndrome (AIDS), transmission of the disease, and, perhaps most important, the steps that the medical profession has taken to protect patients. There was an important lack of understanding by the public regarding transmission of the disease. Thirty-three percent believed it was likely that they could get AIDS from an infected physician. There is good statistical evidence that transmission from patient to health care worker is rare: transmission from physician to patient is even less common. There is almost no risk of a patient acquiring AIDS from his or her physician. However, "almost no risk" is too much risk for ethical physicians to ask their patients to take
State Boards of Registration
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Update: Outbreak of Ebola Viral Hemorrhagic Fever—Zaire, 1995
Journal: JAMA (1995)

As of June 25, public health authorities have identified 296 persons with viral hemorrhagic fever (VHF) attributable to documented or suspected Ebola virus infection in an outbreak in the city of Kikwit and the surrounding Bandundu region of Zaire (1,2); 79% of the cases have been fatal, and 90 (32%) of 283 cases in persons for whom occupation was known occurred in health-care workers. This report summarizes characteristics of persons with VHF from an initial description of cases and preliminary findings of an assessment of risk factors for transmission.