tbuckley/cabot-search huggingface dataset:
Research on the development methodology for clinical practice guidelines for organic integration of traditional Chinese and Western medicine
Authors: Ying-Hui Jin, Yan-Ping Wang, Ying-Lan Xie, Gui-Hua Tian, Xiao-Yu Zhang, Nan-Nan Shi, Ke-Hu Yang, Xin Sun, Yao-Long Chen, Da-Rong Wu, Xin-Feng Guo, Long Ge, Chen Zhao, Cheng Lu, Yin Jiang, Jing Guo, Si-Yu Yan, Yong-Bo Wang, Qiao Huang, Xiang-Ying Ren, Ying-Yue Rao, Yun-Yun Wang, Meng-Qian Yuan, Xian-Tao Zeng, Hong-Cai Shang
Journal: Military Medical Research (2023)

Abstract Integrated traditional Chinese medicine (TCM) and Western medicine (WM) is a new medical science grounded in the knowledge bases of both TCM and WM, which then forms a unique modern medical system in China. Integrated TCM and WM has a long history in China, and has made important achievements in the process of clinical diagnosis and treatment. However, the methodological defects in currently published clinical practice guidelines limit its development. The organic integration of TCM and WM is a deeper integration of TCM and WM. To realize the progression of "integration" to "organic integration", a targeted and standardized guideline development methodology is needed. Therefore, the purpose of this study is to establish a standardized development procedure for clinical practice guidelines for the organic integration of TCM and WM to promote the systematic integration of TCM and WM research results into clinical practice guidelines in order to achieve optimal results as the whole is greater than the sum of the parts.
Primary, secondary and tertiary prevention of Relative Energy Deficiency in Sport (REDs): a narrative review by a subgroup of the IOC consensus on REDs
Authors: Monica Klungland Torstveit, Kathryn E Ackerman, Naama Constantini, Bryan Holtzman, Karsten Koehler, Margo L Mountjoy, Jorunn Sundgot-Borgen, Anna Melin
Journal: British Journal of Sports Medicine (2023)

Relative Energy Deficiency in Sport (REDs) is common among female and male athletes representing various sports at different performance levels, and the underlying cause is problematic low energy availability (LEA). It is essential to prevent problematic LEA to decrease the risk of serious health and performance consequences. This narrative review addresses REDs primary, secondary and tertiary prevention strategies and recommends best practice prevention guidelines targeting the athlete health and performance team, athlete entourage (eg, coaches, parents, managers) and sport organisations. Primary prevention of REDs seeks to minimise exposure to and reduce behaviours associated with problematic LEA. Some of the important strategies are educational initiatives and de-emphasising body weight and leanness, particularly in young and subelite athletes. Secondary prevention encourages the early identification and management of REDs signs or symptoms to facilitate early treatment to prevent development of more serious REDs outcomes. Recommended strategies for identifying athletes at risk are self-reported screening instruments, individual health interviews and/or objective assessment of REDs markers. Tertiary prevention (clinical treatment) seeks to limit short-term and long-term severe health consequences of REDs. The cornerstone of tertiary prevention is identifying the source of and treating problematic LEA. Best practice guidelines to prevent REDs and related consequences include a multipronged approach targeting the athlete health and performance team, the athlete entourage and sport organisations, who all need to ensure a supportive and safe sporting environment, have sufficient REDs knowledge and remain observant for the early signs and symptoms of REDs.
Methodology for studying Relative Energy Deficiency in Sport (REDs): a narrative review by a subgroup of the International Olympic Committee (IOC) consensus on REDs
Authors: Kathryn E Ackerman, Margot Anne Rogers, Ida A Heikura, Louise M Burke, Trent Stellingwerff, Anthony C Hackney, Evert Verhagen, Stacey Schley, Grace H Saville, Margo Mountjoy, Bryan Holtzman
Journal: British Journal of Sports Medicine (2023)

In the past decade, the study of relationships among nutrition, exercise and the effects on health and athletic performance, has substantially increased. The 2014 introduction of Relative Energy Deficiency in Sport (REDs) prompted sports scientists and clinicians to investigate these relationships in more populations and with more outcomes than had been previously pursued in mostly white, adolescent or young adult, female athletes. Much of the existing physiology and concepts, however, are either based on or extrapolated from limited studies, and the comparison of studies is hindered by the lack of standardised protocols. In this review, we have evaluated and outlined current best practice methodologies to study REDs in an attempt to guide future research.This includes an agreement on the definition of key terms, a summary of study designs with appropriate applications, descriptions of best practices for blood collection and assessment and a description of methods used to assess specific REDs sequelae, stratified as either Preferred, Used and Recommended or Potential Researchers can use the compiled information herein when planning studies to more consistently select the proper tools to investigate their domain of interest. Thus, the goal of this review is to standardise REDs research methods to strengthen future studies and improve REDs prevention, diagnosis and care.
2023 International Olympic Committee’s (IOC) consensus statement on Relative Energy Deficiency in Sport (REDs)
Authors: Margo Mountjoy, Kathryn E Ackerman, David M Bailey, Louise M Burke, Naama Constantini, Anthony C Hackney, Ida Aliisa Heikura, Anna Melin, Anne Marte Pensgaard, Trent Stellingwerff, Jorunn Kaiander Sundgot-Borgen, Monica Klungland Torstveit, Astrid Uhrenholdt Jacobsen, Evert Verhagen, Richard Budgett, Lars Engebretsen, Uğur Erdener
Journal: British Journal of Sports Medicine (2023)

Relative Energy Deficiency in Sport (REDs) was first introduced in 2014 by the International Olympic Committee’s expert writing panel, identifying a syndrome of deleterious health and performance outcomes experienced by female and male athletes exposed to low energy availability (LEA; inadequate energy intake in relation to exercise energy expenditure). Since the 2018 REDs consensus, there have been &gt;170 original research publications advancing the field of REDs science, including emerging data demonstrating the growing role of low carbohydrate availability, further evidence of the interplay between mental health and REDs and more data elucidating the impact of LEA in males. Our knowledge of REDs signs and symptoms has resulted in updated Health and Performance Conceptual Models and the development of a novel Physiological Model. This Physiological Model is designed to demonstrate the complexity of either problematic or adaptable LEA exposure, coupled with individual moderating factors, leading to changes in health and performance outcomes. Guidelines for safe and effective body composition assessment to help prevent REDs are also outlined. A new REDs Clinical Assessment Tool-Version 2 is introduced to facilitate the detection and clinical diagnosis of REDs based on accumulated severity and risk stratification, with associated training and competition recommendations. Prevention and treatment principles of REDs are presented to encourage best practices for sports organisations and clinicians. Finally, methodological best practices for REDs research are outlined to stimulate future high-quality research to address important knowledge gaps.
Mapping the complexities of Relative Energy Deficiency in Sport (REDs): development of a physiological model by a subgroup of the International Olympic Committee (IOC) Consensus on REDs
Authors: Louise M Burke, Kathryn E Ackerman, Ida A Heikura, Anthony C Hackney, Trent Stellingwerff
Journal: British Journal of Sports Medicine (2023)

The 2023 International Olympic Committee (IOC) consensus statement on Relative Energy Deficiency in Sport (REDs) notes that exposure to low energy availability (LEA) exists on a continuum between adaptable and problematic LEA, with a range of potential effects on both health and performance. However, there is variability in the outcomes of LEA exposure between and among individuals as well as the specific manifestations of REDs. We outline a framework for a ‘systems biology’ examination of the effect of LEA on individual body systems, with the eventual goal of creating an integrated map of body system interactions. We provide a template that systematically identifies characteristics of LEA exposure (eg, magnitude, duration, origin) and a variety of moderating factors (eg, medical history, diet and training characteristics) that could exacerbate or attenuate the type and severity of impairments to health and performance faced by an individual athlete. The REDs Physiological Model may assist the diagnosis of underlying causes of problems associated with LEA, with a personalised and nuanced treatment plan promoting compliance and treatment efficacy. It could also be used in the strategic prevention of REDs by drawing attention to scenarios of LEA in which impairments of health and performance are most likely, based on knowledge of the characteristics of the LEA exposure or moderating factors that may increase the risk of harmful outcomes. We challenge researchers and practitioners to create a unifying and dynamic physiological model for each body system that can be continuously updated and mapped as knowledge is gained.
Review of the scientific rationale, development and validation of the International Olympic Committee Relative Energy Deficiency in Sport Clinical Assessment Tool: V.2 (IOC REDs CAT2)—by a subgroup of the IOC consensus on REDs
Authors: Trent Stellingwerff, Margo Mountjoy, Walter TP McCluskey, Kathryn E Ackerman, Evert Verhagen, Ida A Heikura
Journal: British Journal of Sports Medicine (2023)

Relative Energy Deficiency in Sport (REDs) has various different risk factors, numerous signs and symptoms and is heavily influenced by one’s environment. Accordingly, there is no singular validated diagnostic test. This 2023 International Olympic Committee’s REDs Clinical Assessment Tool—V.2 (IOC REDs CAT2) implements a three-step process of: (1) initial screening; (2) severity/risk stratification based on any identified REDs signs/symptoms (primary and secondary indicators) and (3) a physician-led final diagnosis and treatment plan developed with the athlete, coach and their entire health and performance team. The CAT2 also introduces a more clinically nuanced four-level traffic-light (green, yellow, orange and red) severity/risk stratification with associated sport participation guidelines. Various REDs primary and secondary indicators have been identified and ‘weighted’ in terms of scientific support, clinical severity/risk and methodological validity and usability, allowing for objective scoring of athletes based on the presence or absence of each indicator. Early draft versions of the CAT2 were developed with associated athlete-testing, feedback and refinement, followed by REDs expert validation via voting statements (ie, online questionnaire to assess agreement on each indicator). Physician and practitioner validity and usability assessments were also implemented. The aim of the IOC REDs CAT2 is to assist qualified clinical professionals in the early and accurate diagnosis of REDs, with an appropriate clinical severity and risk assessment, in order to protect athlete health and prevent prolonged and irreversible outcomes of REDs.
Intersection of mental health issues and Relative Energy Deficiency in Sport (REDs): a narrative review by a subgroup of the IOC consensus on REDs
Authors: Anne Marte Pensgaard, Jorunn Sundgot-Borgen, Carla Edwards, Astrid Urenholdt Jacobsen, Margo Mountjoy
Journal: British Journal of Sports Medicine (2023)

Overall athlete health is a stated priority by the International Olympic Committee (IOC), yet it can be difficult for athletes to safely balance nutritional needs, training load, recovery, social interactions, expectations and other demands. The effect of energy intake and, especially, low energy availability (LEA) on athlete mental health, is understudied. In this narrative review, we examine research that has included psychological factors and mental health variables when investigating the effect of LEA, dieting/restrictive eating and Relative Energy Deficiency in Sport (REDs), since the 2018 IOC consensus statement on REDs. Based on currently available data, early psychological indicators associated with problematic LEA are mood changes, fatigue and psychological conflict. More severe mental health outcomes associated with REDs are reduced well-being, elevated anxiety, depressive symptoms and eating disorders. We propose a psychological model that helps structure how possible risk factors (eg, body dissatisfaction, environmental demands or increased training load) and moderating (eg, gender, sport) and/or potential mediating (eg, social climate, self-esteem) factors are associated with LEA and ultimately REDs. The current scientific literature underscores the importance of including mental health factors when screening for REDs and for developing a clinical approach to address the psychological sequelae of REDs once diagnosed. An interdisciplinary perspective is recommended. Lastly, and importantly, the athlete perspective urges clinicians to not underestimate the drive for success and denial of health consequences that athletes demonstrate when pursuing their sport goals.
Avoiding the ‘REDs Card’. We all have a role in the mitigation of REDs in athletes
Authors: Margo Mountjoy, Kathryn E Ackerman, David M Bailey, Louise M Burke, Naama Constantini, Anthony C Hackney, Ida Aliisa Heikura, Anna Melin, Anne Marte Pensgaard, Trent Stellingwerff, Jorunn Sundgot-Borgen, Monica Klungland Torstveit, Astrid Uhrenholdt Jacobsen, Evert Verhagen, Richard Budgett, Lars Engebretsen, Uğur Erdener
Journal: British Journal of Sports Medicine (2023)
Best practice recommendations for body composition considerations in sport to reduce health and performance risks: a critical review, original survey and expert opinion by a subgroup of the IOC consensus on Relative Energy Deficiency in Sport (REDs)
Authors: Therese Fostervold Mathisen, Timothy Ackland, Louise M Burke, Naama Constantini, Judith Haudum, Lindsay S Macnaughton, Nanna L Meyer, Margo Mountjoy, Gary Slater, Jorunn Sundgot-Borgen
Journal: British Journal of Sports Medicine (2023)

Background The assessment of body composition (BC) in sport raises concern for athlete health, especially where an overfocus on being lighter or leaner increases the risk of Relative Energy Deficiency in Sport (REDs) and disordered eating. Methods We undertook a critical review of the effect of BC on performance (29 longitudinal, prospective or intervention studies) and explored current practice related to BC considerations via a follow-up to a 2013 internationally distributed survey. Results The review found that a higher level of body fat was negatively associated with endurance performance, while a gain in muscle mass resulted in performance benefits across sports. BC did not contribute to early talent identification, and no unique cut-off to signify a performance advantage for BC was identified. BC appears to be one of an array of variables impacting performance, and its influence should not be overstated. The survey (125 practitioners, 61 sports and 26 countries) showed subtle changes in BC considerations over time, such as an increased role for sport dietitian/nutrition practitioners as BC measurers (2013: 54%, 2022: 78%); less emphasis on reporting of body fat percentage (2013: 68%, 2022: 46%) and reduced frequency of BC assessment if ≥every fourth week (2013: 18%, 2022: 5%). Respondents remained concerned about a problematic focus on BC (2013: 69%, 2022: 78%). To address these findings, we provide detailed recommendations for BC considerations, including an overview of preferable BC methodology. Conclusions The ‘best practice’ guidelines stress the importance of a multidisciplinary athlete health and performance team, and the treatment of BC data as confidential medical information. The guidelines provide a health focus around BC, aiming to reduce the associated burden of disordered eating, problematic low energy availability and REDs.
Beyond very early systemic sclerosis: deciphering pre‑scleroderma and its trajectories to open new avenues for preventive medicine
Authors: Alain Lescoat, Silvia Bellando-Randone, Corrado Campochiaro, Francesco Del Galdo, Christopher P Denton, Sue Farrington, Ilaria Galetti, Dinesh Khanna, Masataka Kuwana, Marie-Elise Truchetet, Yannick Allanore, Marco Matucci-Cerinic
Journal: The Lancet Rheumatology (2023)
Women, power, and cancer: a Lancet Commission
Authors: Ophira Ginsburg, Verna Vanderpuye, Ann Marie Beddoe, Nirmala Bhoo-Pathy, Freddie Bray, Carlo Caduff, Narjust Florez, Ibtihal Fadhil, Nazik Hammad, Shirin Heidari, Ishu Kataria, Somesh Kumar, Erica Liebermann, Jennifer Moodley, Miriam Mutebi, Deborah Mukherji, Rachel Nugent, Winnie K W So, Enrique Soto-Perez-de-Celis, Karla Unger-Saldaña, Gavin Allman, Jenna Bhimani, María T Bourlon, Michelle A B Eala, Peter S Hovmand, Yek-Ching Kong, Sonia Menon, Carolyn D Taylor, Isabelle Soerjomataram
Journal: The Lancet (2023)
Paediatric acute hepatitis of unknown aetiology: a national surveillance investigation in the USA during 2021 and 2022
Authors: Jordan Cates, Julia M Baker, Olivia Almendares, Neha Balachandran, Erin R McKeever, Anita K Kambhampati, Caelin Cubenas, Jan Vinjé, Jennifer L Cannon, Preeti Chhabra, Brandi Freeman, Sarah Reagan-Steiner, Julu Bhatnagar, Paul A Gastañaduy, Hannah L Kirking, David Sugerman, Umesh D Parashar, Jacqueline E Tate, Rachel M. Burke, Eleanor Burnett, Everardo M. Vega, Xiaoyan Lu, Melissa M. Coughlin, Bettina Bankamp, Brooke Leitgeb, Lindsey Blythe Coulter Estetter, Lucinia Silva-Flannery, Roosecelis B. Martines, Debra A. Wadford, Christina Morales, Chao-Yang Pan, Michael Popowich, Daryl M. Lamson, Kirsten St. George, Elizabeth Cebelinski, Anna Panek, L. Amanda Ingram, Stephanie Ayers-Millsap, Theresa Dulski, Tameika Reed, Lydia Sietsema, Adrian Savella, Mary P. Derby, James Matthews, Kentaro F. Abe, Kyle R. Rizzo, Lauren J. Stockman, Bonnie L. Dao, Alexis Burakoff, Diana Tapay, Michael Kacka, Paul Gacek, Quyen Phan, Christina Langer, Nikki Kupferman, Ashley Gent, Dalton Dessi, Melissa Tobin-D'Angelo, Ami Gandhi, Kris K. Carter, Matthew T. Leslie, Lori Saathoff-Huber, Nicole Stone, Bethany Hodge, Amanda Odegard, Julia Hand, Juliana Jacoboski, Christine Nguyen, Chloe Manchester, Emer Smith, Macey Ladisky, Geoff Brousseau, Genny Grilli, Mari Freitas, Alexandra Berkley, Michael Do, Jennifer Hanson, Carla Boutwell, Lindsey VanderBusch, Shari Renton, Rachel Goebel, Alice I. Sato, Matthew Donahue, Derek Julian, Krystle Mallory, Deanna Bridges, Deepam Thomas, Anna M Stadelman, Mika Gehre, Nora Holzinger, Melissa Peek-Bullock, Victoria Sepcic, Nitin M Ghadge, Youjung Byun, Bridget J. Anderson, Dominique Balan, Mike Antwi, Brandi Taylor, Courtney Dewart, Ashlyn Wayman, Marie Solberg, Hannah Lund, Nottasorn Plipat, Jennifer L. Wallace, Iris Cardona, Melissa Marzán Rodríguez, Abby L. Berns, Patricia McAuley, Chelsea Campbell, Joshua Clayton, Jessica Schultz, Ryan Wallace, Amelia Prebish Salmanson, Dawn Saady, Tabatha Heaton, Kimberly Carlson, Amanda Dodd, Thomas Haupt, Stephanie D. McLemore, Maria C. del Rosario
Journal: The Lancet Child & Adolescent Health (2023)
Persistence of immunity following a single dose of inactivated poliovirus vaccine: a phase 4, open label, non-randomised clinical trial
Authors: Arun K Sharma, Harish Verma, Concepcion F Estivariz, Luna Bajracharaya, Ganesh Rai, Ganesh Shah, Jeevan Sherchand, Kathryn A V Jones, Bernardo A Mainou, Smita Chavan, Vishali Jeyaseelan, Roland W Sutter, Laxman P Shrestha
Journal: The Lancet Microbe (2023)

The polio eradication endgame required the withdrawal of Sabin type 2 from the oral poliovirus vaccine and introduction of one or more dose of inactivated poliovirus vaccine (IPV) into routine immunisation schedules. However, the duration of single-dose IPV immunity is unknown. We aimed to address this deficiency.
Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors
Authors: Camilla Scarpellini, Greta Klejborowska, Caroline Lanthier, Behrouz Hassannia, Tom Vanden Berghe, Koen Augustyns
Journal: Trends in Pharmacological Sciences (2023)

Ferroptosis is an iron-catalysed form of regulated cell death, which is critically dependent on phospholipid peroxidation of cellular membranes. Ferrostatin 1 was one of the first synthetic radical-trapping antioxidants (RTAs) reported to block ferroptosis and it is widely used as reference compound. Ferroptosis has been linked to multiple diseases and the use of its inhibitors could have therapeutic potential. Although, novel biochemical pathways provide insights for different pharmacological targets, the use of lipophilic RTAs to block ferroptosis remains superior. In this Review, we provide a comprehensive overview of the different classes of ferroptosis inhibitors, focusing on endogenous and synthetic RTAs. A thorough analysis of their chemical, pharmacokinetic, and pharmacological properties and potential for in vivo use is provided.
Covalent fragment approaches targeting non-cysteine residues
Authors: Noémi Csorba, Péter Ábrányi-Balogh, György M. Keserű
Journal: Trends in Pharmacological Sciences (2023)

Covalent fragment approaches combine advantages of covalent binders and fragment-based drug discovery (FBDD) for target identification and validation. Although early applications focused mostly on cysteine labeling, the chemistries of available warheads that target other orthosteric and allosteric protein nucleophiles has recently been extended. The range of different warheads and labeling chemistries provide unique opportunities for screening and optimizing warheads necessary for targeting non-cysteine residues. In this review, we discuss these recently developed amino-acid-specific and promiscuous warheads, as well as emerging labeling chemistries, which includes novel transition metal catalyzed, photoactive, electroactive, and noncatalytic methodologies. We also highlight recent applications of covalent fragments for the development of molecular glues and proteolysis-targeting chimeras (PROTACs), and their utility in chemical proteomics-based target identification and validation.
Reply to Anju Murayama’s Letter to the Editor re: David-Dan Nguyen, Liam Murad, Anne Xuan-Lan Nguyen, et al. Industry Payments to American Editorial Board Members of Major Urology Journals. Eur Urol. Eur Urol. 2023;84:442–43
Authors: David-Dan Nguyen, Anna-Lisa V. Nguyen, Liam Murad, Muhieddine Labban, Quoc-Dien Trinh, Christopher J.D. Wallis, Naeem Bhojani
Journal: European Urology (2023)