AB1026 THE TIME OF INTESTINAL BOWEL DISEASE ONSET IS ASSOCIATED WITH THE PHENOTYPE AND DIAGNOSIS IN PATIENTS WITH SPONDYLOARTHRITIS. RESULTS FROM REGISPONSER REGISTRY
Authors: I. Gómez-García, M. L. Ladehesa Pineda, A. Escudero Contreras, F. U. Pilar, E. Collantes Estevez, P. Ruiz-Limon, C. López-Medina
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Our group has evaluated the impact of the time of appearance of some extramusculoskeletal manifestations in spondyloarthritis. However, we still need to know more about the impact of both the inflammatory bowel disease (IBD) itself and its moment of appearance with respect to rheumatic symptoms. <h3>Objectives</h3> a) to compare SpA characteristics in patients with and without IBD and b) To compare the clinical characteristics and the rheumatologist’s diagnosis in SpA patients with IBD according to the onset of IBD (before vs. after the appearance of rheumatic symptoms). <h3>Methods</h3> This was a cross-sectional study with data extracted from the REGISPONSER (Spondyloarthritis Registry of the Spanish Rheumatology Society) registry. Dates of SpA and IBD onset were available. Two groups were classified depending on the time of appearance of IBD (before or after rheumatic symptoms). The clinical characteristics, disease activity, radiographic damage, functional ability and rheumatologists’ diagnoses were compared between the two groups. Univariate and multivariate logistic regressions were conducted to evaluate the factors associated with each group and chi-square test to evaluate differences in phenotype and rheumatologists’ diagnoses. <h3>Results</h3> A total of 123 of 2367 (5.2%) patients included in the REGISPONSER registry were diagnosed with IBD but 20 patients did not have available date of IBD onset. There was less prevalence of HLA-B27, psoriasis and dactylitis, and less frequency of uveitis in patients with IBD vs patients with SpA without IBD. Moreover, these patients were younger and had less disease duration, and less disease activity (by ASDAS and BASDAI indexes) and functional ability (by BASRI index). Among patients with IBD, 54 (52.4%) already had IBD at the moment of rheumatic symptoms onset, while 49 patients (47.6%) began with IBD after the SpA onset. Peripheral phenotype [10 (18.5%) vs 1 (2%)] was more frequently observed in patients who had been already diagnosed of IBD when rheumatic symptoms began while axial involvement had a lower prevalence [25 (46.3%) vs 33 (67.3%)]. There also were significant differences in rheumatologist’s diagnosis in these patients, with a less frequency of ankylosing spondyloarthritis diagnosis [31 (57.5%) vs 42 (85.7%)] in the first group. After performing a multivariate analysis with demographic and clinical characteristics, we obtained a shorter diagnosis delay [0.90 (CI95% CI 0.82-0.98)] and a less prevalence of HLA-B27 antigen [0.19 (CI95 % 0.07-0.52)] in the former group. <h3>Conclusion</h3> SpA patients with IBD have a less severe disease with less prevalence of extramsuculoskeletal imanifestations. When IBD began before the rheumatic symptoms, it was associated to an earlier diagnosis and a more frequent peripheral phenotype. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.