tbuckley/cabot-search huggingface dataset:
Consolidative radiotherapy in metastatic urothelial cancer (MUC).
Authors: Sandhya Srinivas, Sujata Narayanan, Alice C. Fan, Steven Lee Hancock, Eila C. Skinner
Journal: Journal of Clinical Oncology (2016)

406 Background: Although rarely curative, chemotherapy remains the mainstay for the treatment of MUC. In patients with MUC who achieve either partial or complete response to chemotherapy, the role of consolidative radiation remains unknown Methods: From our single institution database of 2597 patients with urothelial carcinoma (UC) treated since 1997, we identified 22 patients with MUC who underwent consolidative radiotherapy after a partial response to chemotherapy with the intent of rendering them disease free. All patients had undergone primary surgical therapy with either cystectomy or nephroureterectomy. We excluded patients who received radiation for a palliative intent. Progression Free survival (PFS) was defined as time from completion of RT to relapse or last follow up. Overall Survival (OS) was defined as time from start of chemotherapy to death or last follow up. Results: The median age of the patients was 67 years; 64% were men and 59% had received prior cisplatin based chemotherapy. The most common sites radiated were the regional lymph nodes (64%). Other radiated sites included the lung, adrenal glands and omental metastases. Median time from cystectomy to relapse was 22 months. Median survival from diagnosis of cystectomy was 48 months. Median PFS was 13 months and median OS was 29 months. Nine patients (41%)were alive and disease free 6 years after radiation. Conclusions: In this highly selective cohort of patients with MUC treated with consolidative radiation after chemotherapy, 41% were rendered disease free. Patients who were rendered disease free were those with nodal metastases and needing radiation to a single site of metastases. This suggests that radiation is feasible and may contribute to long-term disease control. Further prospective studies should be undertaken to better characterize who would best benefit from this combined consolidative modality treatment strategy.
Abstracts for the Society of Nuclear Medicine and Molecular Imaging, Greater New York and New England Chapters, 26th Annual Northeast Regional Scientific Meeting
Journal: Clinical Nuclear Medicine (2013)

Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Current IssuePrevious IssuesPublished Online First Collections ACNM MeetingsCMECommunication in OrganizationCOVID-19Feedback and RewardsFrom the American College of Nuclear MedicineHighly Cited and Frequently Read ArticlesPlanning and Conducting Meetings EffectivelyQuality and Safety in Health CareRecruitment of New PhysiciansTips for Giving a Memorable PresentationTips for LeadersTips for Physicians in Getting the Right Job ACNM ArticlesACNM Website For Authors Submit a ManuscriptInformation for AuthorsLanguage Editing ServicesAuthor Permissions Journal Info About the JournalEditorial BoardAdvertisingOpen AccessSubscription ServicesReprintsRights and Permissions All Articles Images Videos Podcasts Blogs Advanced Search
Characterization of Arsenic Compounds Formed by Daphnia magna and Tetraselmis chuii from Inorganic Arsenate
Authors: K. J. Irgolic, E. A. Woolson, R. A. Stockton, R. D. Newman, Nestor R. Bottino, R. A. Zingaro, P. C. Kearney, R. A. Pyles, Shigeru Maeda, W. J. McShane, Elenor R. Cox
Journal: Environmental Health Perspectives (1977)

Experiments to grow Tetraselmis chuii (a marine alga) and Daphnia magna in the presence of inorganic arsenate are described. The algae incorporate arsenic rather efficiently and form a lipid-soluble organic arsenic compound. T. chuii has been successfully mass cultured in a medium containing 10 ppm arsenic as arsenate. Daphnia magna was cultured in a medium containing 74As-labeled H3AsO4 and 1 ppm Na2HAsO4 expressed as arsenic. The arsenic metabolites were extracted with a chloroform-methanol solution and isolated by using column and thin-layer chromatography. TLC analysis of the metabolites revealed the presence of a 74As-containing product which migrated with phosphatidylethanolamine. This product was hydrolyzed with the phospholipases A, C, and D. The experimental results are not inconsistent with the presence of an arsenocholine moiety in the lipids. Arsenocholine, arsenobetaine, and acetylarsenocholine have been synthesized and will serve as reference substances in the chromatography experiments. The preparation of arsenocholine-containing lipids is in progress.
Landmark article Aug 6, 1955: Considerations in the preparation and use of poliomyelitis virus vaccine. By Jonas E. Salk
Authors: J. E. Salk
Journal: JAMA (1984)

In assessing the state of knowledge of any subject at a particular point in time, it is as important to define what is not known as it is to appreciate what is known. It is for this reason that I would like to discuss some of the problems still before us, with respect to vaccination against poliomyelitis, as well as to review knowledge gained in the course of recent work. "Can durable immunity be induced by a noninfectious poliomyelitis vaccine?" is one of the principal questions still to be answered. Since the ultimate answer to this question cannot be obtained until time has passed, we must content ourselves only with an examination of facts now known, from which we can make some tentative interpretations from the trends observed. The hypothesis that the presence of neutralizing antibody in the circulating blood is an effective barrier in reducing the likelihood of paralysis
11. Microvascular Complications and Foot Care: <i>Standards of Medical Care in Diabetes−2020</i>
Journal: Diabetes Care (2019)

The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes the ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee (https://doi.org/10.2337/dc20-SPPC), are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recommendations, please refer to the Standards of Care Introduction (https://doi.org/10.2337/dc20-SINT). Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
Bile acids suppress the secretion of very-low-density lipoprotein by human hepatocytes in primary culture
Authors: Y Lin
Journal: Hepatology (1996)

The existence of a relationship between bile acid and triacylglycerol metabolism in humans has been established, but the underlying mechanism and its physiological relevance have remained unclear. We have studied the effects of bile acids on the secretion of very-low-density lipoprotein (VLDL)-associated triacylglycerol, using [3H]glycerol labeling technique, and apolipoprotein B (apoB) in human hepatocytes in primary culture. Human hepatocytes secrete nascent VLDL with an average diameter of about 40 nm. Lipid composition of the particles resembles that reported for plasma VLDL, with the exception of a markedly lower cholesterylester content. In 24-hour cultured human hepatocytes, physiological (i.e., portal) concentrations of taurocholic acid (10 to 200 μmol/L) suppressed [3H]triacylglycerol secretion dose dependently. The degree of inhibition highly correlated (r = .87, P < .01) with taurocholic acid content of the cells of different preparations (n = 7). ApoB secretion was inhibited by taurocholic acid to a similar extent as [3H]triacylglycerol secretion (r = .93, P < .01). Lipid composition of secreted VLDL particles did not change during taurocholic acid-induced suppression. No effects on intracellular apoB, [3H]triacylglycerol, triacylglycerol, and cholesterol mass were observed, nor did taurocholic acid affect protein synthesis, albumin secretion, or lactate dehydrogenase (LDH) release. Cellular cholesteryl ester (CHE) mass, however, was markedly reduced. Our results show that bile acids strongly interfere with the assembly or secretion of VLDL particles by human hepatocytes, suggesting a physiological function of the enterohepatic circulation of bile acids in the regulation of postprandial serum lipid levels.
Baby Book
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The inexact use of Fisher's Exact Test in six major medical journals
Authors: W. P. McKinney
Journal: JAMA (1989)

We reviewed the use of Fisher's Exact Test in 71 articles published between 1983 and 1987 in six medical journals. Thirty-three of 56 selected articles did not specify use of a one- or two-tailed test, and 12 (36%) of these actually used the one-tailed test. Five (42%) of these 12 articles contained at least one table in which the standard significance level of<i>P</i>&lt;.05 was no longer met when a two-tailed analysis was run instead. Eleven (65%) of 17 articles with a statistical consultant compared with 10 (28%) of 36 articles without a consultant specified use of a one- or two-sided test. The use of Fisher's Exact Test without specification as a one- or two-tailed version may misrepresent the statistical significance of data. A uniform specification statement should be required for all manuscripts to correct such potential errors in interpretation. (<i>JAMA</i>. 1989;261:3430-3433)
Community Responsibility for Stabilizing Trauma Systems-Reply
Authors: Dennis P. Andrulis
Journal: JAMA (1997)

<h3>In Reply.</h3> —My article, which was based on the report by Cornwell et al<sup>1</sup>on trauma care at Los Angeles County+University of Southern California, was intended to point out that the near-crisis situation was not limited to that provider or that community. I had also stressed that Dallas had pulled back from the brink of crisis and created opportunity. While in some areas the support system for these services remains fragile, my article and Dr Anderson's letter stress the tangible benefit of cooperation within the Dallas hospital community in creating a stable environment in which citizens can be guaranteed continued access to high-quality trauma care. To that end the real take-away message is not only what recognition of shared responsibility and support can accomplish, but also what consequences may befall communities without it.
Role of ventriculo vascular coupling in cardiac response to increased contractility in closed-chest dogs
Journal: Journal of Clinical Investigation (1991)

Due to a printer's error, a line of type was dropped from the third and fourth sentences of the introduction to this article.The complete third and fourth sentences should read:Two mechanisms by which this can occur are adrenergic stimulation and increased heart rate, or the force-frequency effect.Studies in isolated muscle segments (1-3) and in intact hearts (4-6) have shown that both ofthese stimuli increase the inotropic state ofthe myocardium.
Piperazine
Authors: F. Hartley
Journal: BMJ (1955)

<h3>Abstract</h3> Fomite-mediated transmission has been identified as a possible route for disease spread of the COVID-19 pandemic. In healthcare settings, evidence of environmental contamination by SARS-CoV-2 has been found in patients’ rooms and toilets. Here, we investigate environmental contamination of SARS-CoV-2 in non-healthcare settings and assessed the efficacy of cleaning and disinfection in removing SARS-CoV-2 contamination. A total of 428 environmental swabs and six air samples was taken from accommodation rooms, toilets and elevators that have been used by COVID-19 cases. Through the use of a sensitive nested RT-PCR assay, we found two SARS-CoV-2 RNA positive samples from the room resided by a COVID-19 case, highlighting the risk of fomite-mediated transmission in non-healthcare settings and the importance of surface disinfection of spaces occupied by cases. Of note, we did not find evidence for air-borne transmission, nor of environmental contamination of elevators, which were transiently exposed to infected persons.
The IASLC Lung Cancer Staging Project: Proposals for the Revisions of the T Descriptors in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer
Authors: Ramón Rami-Porta, Vanessa Bolejack, John Crowley, David Ball, Jhingook Kim, Gustavo Lyons, Thomas Rice, Kenji Suzuki, Charles F. Thomas, William D. Travis, Yi-Long Wu
Journal: Journal of Thoracic Oncology (2015)
Immune Deficiency As a Risk Factor in Epstein-Barr Virus-Induced Malignant Diseases
Authors: David Theodore Purtilo, Motohiko Okano, Helen L. Grierson
Journal: Environmental Health Perspectives (1990)

Epstein-Barr virus (EBV) is a ubiquitous DNA virus that normally infects silently, establishing lifelong latency. Substantial empirical observations support the view that immunodeficiency is permissive in EBV-induced lymphoproliferative diseases (LPD). Primary immune deficient patients such as those with X-linked lymphoproliferative disease and individuals with acquired immune deficiency secondary to immunosuppressive drugs for organ transplantation or individuals infected with human immunodeficiency virus are also at very high risk for lethal LPD. The importance of immunodeficiency and EBV in the development of head and neck carcinomas and uterine cervical carcinoma is less clear. Methods are available for detecting immunodeficiency and EBV genome and thus preventive strategies are being developed to preclude LPD from occurring.
Fibrinolysis
Authors: Saul I. Cohen, Richard Warren
Journal: New England Journal of Medicine (1961)

Inhibition of the Fibrinolytic SystemMechanism of Inhibition of Plasminogen Activation and Plasmin ActionInhibition of plasminogen activation probably depends on the presence of substances in blood that fulfill the substrate specificity requirements of the plasminogen activator and contain specific chemical groupings analogous to those present in plasminogen. Inhibition of plasmin-fibrin interaction depends on the presence of substances resembling or containing structural units present in plasmin's natural substrate, fibrin. The molecular proximity of the substrate is important in the potential interaction between an enzyme and competing substrates, as in the situation in which the substrate fibrin and the substrate "plasmin . . .
Prescribing clindamycin
Authors: N MacLeod
Journal: BMJ (1981)

patients in less time.Its use minimises the patient's suffering and time off work, and also results in a considerable saving in dressings and nurses' and doctors' time.Now that the very occasional risk of a patient developing pseudomembranous colitis is well known and because this complication, should it occur, can be effectively treated for a modest expense, I consider it appropriate to continue giving our patients the benefit of this very effective antibiotic.
Use of prophylaxis for malaria by American travelers to Africa and Haiti
Authors: H. O. Lobel
Journal: JAMA (1987)

EACH year, approximately 1 million Americans travel to countries where they may be exposed to malaria.<sup>1</sup>Infections with<i>Plasmodium falciparum</i>in such travelers are of particular concern because these infections can be fatal.<sup>2</sup>Use of effective chemoprophylaxis can reduce the risk of infection from malaria considerably.<sup>3</sup>All travelers to malariaendemic countries are advised to take chloroquine each week as chemoprophylaxis. In addition, from 1982 until April 1985, the Centers for Disease Control (CDC) advised travelers to countries with chloroquine-resistant<i>P falciparum</i>to also take pyrimethamine-sulfadoxine each week.<sup>4</sup>However, information on cases of malaria in the United States reported to the CDC suggests that use of chemoprophylaxis by US travelers is incomplete: only 28% of the 410 US patients infected with<i>P falciparum</i>in Africa between 1980 and 1984 had used a recommended drug regimen for prophylaxis, and none of the 58 patients with<i>P falciparum</i>infections
Cytomegalovirus esophagitis preceding the diagnosis of systemic lupus erythematosus
Authors: R. Kellermayer, S. Kim, M. Perez, N. Tatevian, M. Dishop, S. Abrams, S. Kitagawa, M. Gilger
Journal: Endoscopy (2007)

Correction to: Cytomegalovirus esophagitis preceding the diagnosis of systemic lupus erythematosusEndoscopy 2007; 39(S 1): E218-E218DOI: 10.1055/s-2007-966413
The Care of the Skin in Health.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAMA Psychiatry
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Kevin Brown, Amanda Ehrhardt, Iris Lo, Michaela Mark, M Newman, Suzanne Walker, Connie Manno, Sara Billings, Timothy Gray, Paul Ruich, Catherine Copyreaders, Stephanie Alden, Jan Beckmeyer, Mary Clavey, Paula Coerver-Connolly, Laura Glitman, Joseph King, Brandy Mills, Donna Patton, Editorial Thordsen, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Williams, Fanny Brown, Lenette Gardner-Gullens, Erin Kato, Peter Kim, Rachell Lozano, Caroline Sietmann, Angelia Waltower, Elizabeth Scientifi, Michael Berkwits, Eric Butkus, Michelle Kurzynski, Emily Ling, Jesse Mcquarters, Daniel Morrow, Daniella Peting, Reuben Rios, Carrie Butt, Mary Ferkaluk, Ronna Henry, Karen Bucher, Andy Rekito, Nick Reback, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Deanna Bellandi, Jim Managers, Rick Bell, Fergus Clare, Lindsay Dawson, Will English, Ellen Gibson, Mustafa Ishaq, Craig Mccaff Rey, Michael Mcgraw, Daniel Pickhardt, Romando Rossini, Stacy Business, Analyst Sirisha, Alluri Staff, Millette Jackson-Bates, Karl Elvin, Nancy Essex, Jaye Mize, Sean O'donnell, Sue Managers, David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Scott Curl, Diane Darnell, Jordynn Farrar, Colleen Kelly, Chris Meyer, Annemarie Neff, J Neff, Sean Ohlson, Phil O'leary, Bill Pedone, Susan Price, Binita Shah, Denise Steinhauser, Erin Van Dusen, Joe Advertising, Production Services, Ahmed Avendano, Kim Boler, Rhonda Brown, Fin Carter, Michael Deegan, Daniel Degroot, Euwanaha Joiner-Smith, Joshua Lane, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Mary Sieck, Sarah Subramanian, Geneine Van, Someren Composition, New Media, Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Maleeka Holden, Teri Hutchison, Mary Kuranda, Joshua Lampinen, Nathan Mitre, Patricia Panek, La Son Diggs, Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Daniel James, Judith Literskis, Teresa Omiotek, Michael Ryder, James Madara, Bernard Hengesbaugh, Dan Blazer, North Carolina, David Braff, La Jolla, Stephen California, Washington Dager, Atlanta Druss, Susan Georgia, New Essock, New York, Ellen York, James Frank, Maryland Harris, S Kenneth, Virginia Kendler, C Ronald, Kathleen Kessler, Maryland Merikangas, Judith Samples O'malley, Maryland Rapoport, F Charles, Myrna Reynolds, New Weissman, Charles York, St Zorumski, Shitij Kapur, Michael Owen, Fmed Sci, Naomi Wray, Roy Grinker Sr, Daniel Freedman, Jack Barchas, Joseph Coyle, Constance Murphy, Martin Paulus, Christine Konradi, Helena Chmura Kraemer, Palo Alto, Howard Bauchner, Dost Ongür
Journal: JAMA Psychiatry (2018)
Graft-vs-host reaction following a single blood transfusion
Authors: W. E. Hathaway
Journal: JAMA (1967)

The graft-vs-host (GVH) reaction occurred in an 11-month-old boy with thymic alymphoplasia and progressive vaccinia who had received a single whole blood transfusion. The principal manifestations of the GVH reaction were hepatosplenomegaly, dermatitis, diarrhea, aplastic anemia, and histiocytosis of the spleen and lymph nodes. The findings in this patient are quite similar to those of other previously reported cases of possible human runt disease. This case study emphasizes the dangers of smallpox vaccination or blood tranfusion in infants with thymic alymphoplasia or one of the variants of this syndrome.
Nonfluorescent tinea capitis in Charleston, SC. A diagnostic problem
Authors: E. Prevost
Journal: JAMA (1979)

Statistics gathered at the Medical University of South Carolina from 1973 to 1978 indicate a dramatic change in the etiologic agents of tinea capitis in Charleston since the 1950s. The preponderant agent is now<i>Trichophyton tonsurans</i>, which produces lesions that are not fluorescent in a Wood's lamp examination (long-wave ultraviolet).<i>Trichophyton tonsurans</i>caused 90.6% of 265 culture-proved cases of tinea capitis in the 1970s, but in the 1950s it was responsible for only 1.6% of 378 cases. The study emphasizes that cultures are necessary because the increase in nonfluorescent tinea capitis throughout the United States presents unsuspected diagnostic problems to physicians who are not aware of the change in etiologic agents. (<i>JAMA</i>242:1765-1767, 1979)