tbuckley/cabot-search huggingface dataset:
Diagnostic Reasoning
Authors: Arabella L. Simpkin, Jatin M. Vyas, Katrina A. Armstrong
Journal: Annals of Internal Medicine (2018)

Letters15 May 2018Diagnostic ReasoningArabella L. Simpkin, MD, MMSc, Jatin M. Vyas, MD, PhD, and Katrina A. Armstrong, MD, MSCEArabella L. Simpkin, MD, MMScMassachusetts General Hospital, Boston, Massachusetts (A.L.S., J.M.V., K.A.A.)Search for more papers by this author, Jatin M. Vyas, MD, PhDMassachusetts General Hospital, Boston, Massachusetts (A.L.S., J.M.V., K.A.A.)Search for more papers by this author, and Katrina A. Armstrong, MD, MSCEMassachusetts General Hospital, Boston, Massachusetts (A.L.S., J.M.V., K.A.A.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L18-0012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We were delighted to read these comments and are pleased that our commentary resonated and struck a chord. As these comments thoughtfully address, there are undoubtedly barriers to rebuilding a focus on diagnostic reasoning in today's medical environment, which often seeks to transform a patient's gray-scale narrative into a black-and-white “diagnosis” that can be neatly categorized and labelled as quickly as possible (1). In the United States, we recognize that financial pressures (such as relative value units linked to remuneration and revenue targets) often take the blame for shifting focus away from diagnostic reasoning time to billable encounters. ...References1. Simpkin AL, Schwartzstein RM. Tolerating uncertainty—the next medical revolution? N Engl J Med. 2016;375:1713-5. [PMID: 27806221] CrossrefMedlineGoogle Scholar2. Elder AT, Verghese A. Bedside matters—putting the patient at the centre of teaching and learning [Editorial]. J R Coll Physicians Edinb. 2015;45:186-7. [PMID: 26517094] doi:10.4997/JRCPE.2015.301 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Massachusetts General Hospital, Boston, Massachusetts (A.L.S., J.M.V., K.A.A.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M17-0163. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDiagnostic Reasoning: An Endangered Competency in Internal Medicine Training Arabella L. Simpkin , Jatin M. Vyas , and Katrina A. Armstrong Diagnostic Reasoning David M. Mitchell Diagnostic Reasoning Paul F. Griner Diagnostic Reasoning Liliana Grigorita , Andreea Stan , and Boban Thomas Metrics 15 May 2018Volume 168, Issue 10Page: 751-752KeywordsDisclosureElectronic medical recordsFearGraduate medical educationHealth careHospitalistsMedical educationPhenotypesReasoningUndergraduates ePublished: 15 May 2018 Issue Published: 15 May 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Presentation Remarks
Authors: Donovan F. Ward
Journal: JAMA (1965)

The debt of the American Medical Association to the medical schools of America is great indeed. But to no school is this debt greater than to the first one, the University of Pennsylvania School of Medicine, which was founded 200 years ago this year. Many of you may know that the first President of the AMA, Dr. Nathaniel Chapman, was a graduate of Pennsylvania. But you may not know that six of the first 12 AMA presidents also were Pennsylvania alumni. In fact, in its first 100 years, the AMA had no less than 20 presidents who were graduates of the University of Pennsylvania. Looking to the immediate future we see that our current President-elect, Dr. James Z. Appel, is another Pennsylvania man. He will be the 22nd Pennsylvania graduate to serve as AMA President. You may be wondering how a man who graduates from an outstanding school of medicine
Active and Passive Smoking and Pathological Indicators of Lung Cancer—A Report of Limited Value?
Authors: David J. Doolittle
Journal: JAMA (1993)

<h3>To the Editor.</h3> —The US Environmental Protection Agency (EPA) has recently issued a draft summary of epidemiological data that they believe suggest that exposure to ETS is a risk factor for lung cancer in nonsmokers. Although some of the assumptions in the EPA risk assessment are still under discussion and the EPA has not issued a final report on this matter, the correlation suggested by the epidemiological studies is certainly worthy of detailed biological investigation. Biologically based hypotheses are normally evaluated in a series of carefully controlled studies in cultured cells, in laboratory animals, and to the extent possible, in humans. Following publication of the EPA draft report suggesting an epidemiological association between ETS exposure and lung cancer risk, our laboratories carried out a series of tests in cultured cells and in laboratory animals to test the hypothesis that biological damage could be caused by concentrations of ETS found in
Abstract 494: Intravital discovery of miRNA drivers of human cancer cell directional invasion
Authors: Konstantin V. Stoletov, Lian Willetts, Juan Jovel, Emma Woolner, John D. Lewis
Journal: Cancer Research (2018)

Abstract Metastatic cancer cells use directional ECM cues such as blood vessels or collagen fibers when invading through live tissue. Oncogenic miRNAs have been implicated as key regulators of cancer progression, yet the systemic discovery of miRNAs that drive directional cancer cell invasion has not been achieved. Here we describe the first in vivo quantitative whole human miRNAome screen for miRNA drivers of directional cancer cell invasion that is based on high-resolution intravital imaging. We identified several novel miRNAs that promote cancer cell invasion during the key rate-limiting step of cancer metastasis: the initiation of overt metastatic lesions. In vivo 4D cancer cell tracking revealed that these prometastatic miRNAs are required for successful invasion into collagen-rich tissue and for attachment to the outer surface of the vascular wall. Deregulation of these miRNAs led to formation of loose contacts with the vasculature and chaotic, nondirectional cancer cell invasion patterns in living tissue. Intravital SHG microscopy showed that inhibition of the expression of these miRNAs blocked the ability of cancer cells to rearrange the disorganized collagen network into collagen fiber bundles and stably protrude along these bundles. Further imaging analysis revealed that this miRNA expression specifically blocks vesicular transport of key cell invasion machinery proteins such as MT1-MMP to the cancer cell invadopodia. Human cancer gene expression database analysis showed that our top miRNA candidates are specifically deregulated in invasive pancreatic cancer. Indeed, intravital imaging analysis showed that blocking of metastatic miRNA function inhibited MT1-MMP secretion and ECM degradation by human pancreatic cancer cells. In summary, we identified a novel panel of human miRNAs that are functionally involved in the regulation of directional invasion and metastasis. This work establishes these miRNAs as promising therapeutic targets to block the metastatic spread of lethal cancers. Citation Format: Konstantin V. Stoletov, Lian Willetts, Juan Jovel, Emma Woolner, John D. Lewis. Intravital discovery of miRNA drivers of human cancer cell directional invasion [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 494.
Neasden memorandum on resuscitation.
Journal: BMJ (1967)

MEDICAL JOURNAL highest in young children.Two out of three patients were suffer- ing from infection of the upper respiratory tract or trauma.It appeared that the distance the patient lived from the surgery played little part in his decision to seek medical advice urgently.Eighty-six patients were responsible for about a quarter of all attendances, and 146 families for almost half of all urgent demands.The measures proposed to be taken on the basis of these results are outlined.We wish to record our thanks to Dr. E. D. Acheson, Director of the Oxford Record Linkage Study, for his helpful advice
Blood Safety Monitoring Among Persons With Bleeding Disorders—United States, May 1998–June 2002
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Characteristics of the U.S. EPA's Office of Pesticide Programs' Toxicity Information Databases
Authors: Kerry L. Dearfield, John A. Quest, Rick J. Whiting, H. Frank Stack, Michael D. Waters
Journal: Environmental Health Perspectives (1991)

The United States Environmental Protection Agency's Office of Pesticide Programs (OPP) requires that data from toxicity testing be submitted to the OPP to support the registration of pesticide chemicals. Once the toxicity data are submitted, they are entered into various toxicity databases. The studies are listed in an archival database to catalog and allow retrieval of the study for review. Reviews of toxicity studies are then placed into a separate database that can be retrieved to support a regulatory position. Toxicity information for health effects other than cancer and gene mutations from chronic exposure is reviewed through a reference dose (RfD) approach, and these decisions and supporting data are entered into an RfD database. Carcinogenicity data are reviewed by a peer review process, and these decisions are entered into a newly developed database to show the regulatory decision with supporting data. The mutagenicity data are reviewed and acceptable data are entered into the Genetic Activity Profile system to catalog and display the submitted information. These databases contain the information used for hazard evaluations as part of the OPP review of pesticide chemicals.
Clinical Ethics
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
L'Adénopathie Trachéo-Bronchique Simple Chez l'Enfant. (Etiologie, Pathogénie, Complications Broncho-Pulmonaires). Par le Docteur Henri Forgeron, Ancien Externe des Hôpitaux de Paris.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Treatment of liver failure.
Journal: BMJ (1973)

The clinical syndrome is well-defined.1-5It is commoner in boys than girls.Sometimes other members of the family are affected, but these cases must be distinguished from Alport's syndrome of hereditary nephritis and deafness, in which the prognosis is more sinister.Haematuria, visible to the naked eye, occurs in bouts lasting a day or two and recurs at intervals of ftom a few days to several months or even years.Attacks often occur at the height of an acute febrile illnesss, such as a cold or influenza, or after exercise.They may be accompanied by a little malaise, loin pain, or dysuria.Betweeen attacks microscopic haematuria is found in about half of the patients.Oedema and hypertension are
Medical malpractice
Authors: J. P. LoGerfo
Journal: JAMA (1979)

Dr LoGerfo has two major objections to our article. First, he says that medical characteristics were not controlled methodologically when the effects of sociodemographic factors on litigation were examined. By voicing this objection, Dr LoGerfo has made the assumption that the relationships between the sociodemographic factors and the likelihood of the litigation may be spurious because of their mutual correlations with medical characteristics. We wish that Dr LoGerfo had cited his references, if any, in support of his statement concerning "preexisting knowledge about determinants of malpractice and the sociodemographic correlates of use of surgical procedures," so that we might have related them to our more refined statisticalanalysis reported here. Dr LoGerfo has suggested that we should have used a different sampling technique for selecting our control group of nonclaimants. However, our article should be viewed in its proper context; it simply represents a refinement of the earlier
The Conquest of Cancer.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Persistent Cushing's syndrome apparently cured by ectopic adrenalectomy
Authors: G. O. Strauch
Journal: JAMA (1972)

Bilateral total adrenalectomy failed to cure Cushing's syndrome due to adrenal hyperplasia in the case presented here. However, removal of bilateral paraovarian nodules of ectopic adrenocortical tissue resulted in abolition of Cushing's syndrome. Determination of cortisol in venous blood from various locations was useful in diagnostic evaluation.
Walking Study: Women Outpace Men
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3198: RAGE-directed Imaging of Atherosclerotic Plaque in a Murine Model of Spontaneous Atherosclerosis
Authors: Yared Tekabe, Qing Li, Marija Sedlar, Stan Majeweski, Ann Marie Schmidt, Lynne L Johnson
Journal: Circulation (2007)

Introduction: The receptor for advanced glycation end products (RAGE) interacts with distinct molecules implicated in the development and progression of atherosclerosis. We assessed the hypothesis that 99m Tc-labeled anti-RAGE F(ab’)2 fragments can be used as a noninvasive tool to access atherosclerotic lesion in apolipoprotein E deficient (apoE −/− ) mice. Methods: We developed a novel antibody in rabbits against the V-type Ig extracellular domain of RAGE. Five 20 wk apoE −/− mice fed a high-cholesterol diet plus 2 C57BL/6 mice were injected with 21.6 MBq (0.5 mCi) 99m Tc-labeled anti-RAGE F(ab’)2 fragments and two 20 wk apoE −/− were injected with non-immune rabbit IgG. All mice were imaged on a high resolution parallel hole gamma camera 4 hr after injection (time based on blood pool clearance). Animals were sacrificed and the aortic tree dissected and photographed, and the root and proximal aorta sectioned for immunohistochemical staining after gamma scintillation counting. Results: All five apoE −/− mice injected with 99m Tc-labeled anti-RAGE F(ab’)2 fragments were scan positive. Both disease and antibody controls were scan negative. The mean percentage injected dose per gram (%ID/g) for scan positive was 3.35 and for scan negative &lt;1.0. In vivo image and histology are shown below. Conclusion: RAGE imaging identifies atherosclerotic lesions with vulnerable features..
A Preliminary Analysis of FLAM (Italian Non-Interventional Multi-center Study of FLT3 mutated AML patients): FLT3 Receptor Gene Mutational Analysis and FLT3 Inhibitors Administration in the Real-Life Clinical Practice
Authors: Jacopo Nanni, Ernesta Audisio, Maria Benedetta Giannini, Barbara MD Scappini, Benedetta Cambò, Francesco Albano, Maria Paola Martelli, Alessandro Cignetti, Gian Matteo Rigolin, Nicola Fracchiolla, Monica Bocchia, Claudio Romani, Elisabetta Todisco, Monia Lunghi, Anna Maria Mianulli, Daniela Cilloni, Elisabetta Petracci, Irene Valli, Chiara Zingaretti, Claudio Cerchione, Delia Cangini, the FLAM collaborative Group, Cristina Papayannidis, Giovanni Martinelli
Journal: Blood (2020)
Patient Care after Percutaneous Coronary Artery Interventions
Authors: Iyad Rashdan
Journal: Annals of Internal Medicine (1998)

Letters1 April 1998Patient Care after Percutaneous Coronary Artery InterventionsIyad Rashdan, MDIyad Rashdan, MDUniversity of Oklahoma Health Sciences Center; Oklahoma City, OK 73104Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-7-199804010-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their excellent review [1], O'Meara and Dehmer mention that many drugs have been used to inhibit restenosis but that favorable effects were found only in some small studies and no large randomized trial has identified an effective drug. However, a large randomized, well-designed study [2] showed that treatment with probucol substantially reduces luminal narrowing after balloon coronary angioplasty.In this study of 317 patients, 500 mg of probucol was given twice daily for 4 weeks before and 6 months after angioplasty. The restenosis rate (as defined by quantitative coronary angiography) was 38.9% in the placebo group ...References1. O'Meara JJ, Dehmer GJ. Care of the patient and management of complications after percutaneous coronary artery interventions. Ann Intern Med. 1997; 127:458-71. Google Scholar2. Tardif JC, Cote G, Lesperance J, Bourassa M, Lambert J, Doucet S, et al. Probucol and multivitamins in the prevention of restenosis after coronary angioplasty. Multivitamins and Probucol Study Group. N Engl J Med. 1997; 337:365-72. Google Scholar3. Serruys PW, de Jaegere P, Kiemeneij F, Macaya C, Rutsch W, Heyndrickx G, et al. A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease. Benestent Study Group. N Engl J Med. 1994; 331:489-95. Google Scholar4. Fischman DL, Leon MB, Baim DS, Schatz RA, Savage MP, Penn I, et al. A randomized comparison of coronary-stent placement and balloon angioplasty in the treatment of coronary artery disease. Stent Restenosis Study Investigators. N Engl J Med. 1994; 331:496-501. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Oklahoma Health Sciences Center; Oklahoma City, OK 73104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1998Volume 128, Issue 7Page: 598KeywordsAngioplastyCoronary angioplastyCoronary arteriesDrugsHigh density lipoprotein cholesterolPatientsQuantitative coronary angiographyRandomized trialsVitamin CVitamin E Issue Published: 1 April 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Correction to: MicroRNA-30d promotes angiogenesis and tumor growth via MYPT1/c-JUN/VEGFA pathway and predicts aggressive outcome in prostate cancer
Authors: Zhuo-yuan Lin, Guo Chen, Yan-qiong Zhang, Hui-chan He, Yu-xiang Liang, Jian-heng Ye, Ying-ke Liang, Ru-jun Mo, Jian-ming Lu, Yang-jia Zhuo, Yu Zheng, Fu-neng Jiang, Zhao-dong Han, Shu-lin Wu, Wei-de Zhong, Chin-Lee Wu
Journal: Molecular Cancer (2019)

After publication of the article [1], the author reported that this article contained some errors.