Abstract 1191: The Cancer Complexity Knowledge Portal: Enabling the exploration, discovery and reuse of resources for interdisciplinary cancer research
Authors: James Eddy, milen Nikolov, Brynn Zalmanek, Verena Chung, Julie Bletz
Journal: Cancer Research (2022)

Abstract The National Cancer Institute Division of Cancer Biology supports multiple research programs composed of interdisciplinary scientific communities that integrate approaches, data, and tools to address fundamental challenges in basic and translational cancer research. As the coordinating center for the CSBC and PS-ON, Sage Bionetworks is dedicated to fostering an open and collaborative scientific culture in which researchers can rapidly collaborate across institutional boundaries. Towards this end, we developed the Cancer Complexity Knowledge Portal (cancercomplexity.synapse.org) as a community research resource that synthesizes and exposes the activities and outputs of the CSBC, PS-ON, and affiliated consortia. The portal links related resources (e.g., a grant to its publications) and provides search and faceting to accelerate discovery and collaboration in the cancer research community. We aim to provide rich context about along with access to the activities and contributors that have produced the resources hosted within this and other repositories. The portal currently hosts &amp;gt;75 grants, &amp;gt;2100 publications, &amp;gt;450 datasets, &amp;gt;150 tools, and ~250,000 files. These have been annotated to facilitate search and discoverability in collaboration with and through the generous efforts of the CSBC/PS-ON community and the NCI. The Cancer Complexity Knowledge Portal supports flexible, responsive exploration of and access to curated resources and distilled knowledge through modern web components. Those resources are hosted in community databases (e.g., GEO and SRA) or within the Synapse data-sharing platform (synapse.org/csbcpson). As a back end for the portal, Synapse continues to provide a community workspace to upload, update, manage, browse, and download data via a web UI and APIs. We are excited to provide this portal as a resource to drive additional insight, discovery, and collaboration in the field. In the coming year, we will continue to make updates to the portal, ensuring the latest publications, tools and data are available and identifying new features to add value to the portal for the community. We plan to provide a richer catalog of computational tools, leveraging in part the efforts, interests, and methodological output of CSBC/PS-ON working groups. We will continue to work with Division of Cancer Biology programs to ensure that the portal is enabling the broader community to integrate the approaches, data, and tools needed to address important questions in basic and translational cancer research. Citation Format: James Eddy, milen Nikolov, Brynn Zalmanek, Verena Chung, Julie Bletz. The Cancer Complexity Knowledge Portal: Enabling the exploration, discovery and reuse of resources for interdisciplinary cancer research [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1191.