tbuckley/cabot-search huggingface dataset:
BOOK REVIEW
Authors: L. C. CLARK
Journal: JNCI Journal of the National Cancer Institute (1994)

BOOK REVIEW Get access Progress and Perspectives in Chemoprevention of Cancer G. De Palo , M. Sporn , U. Veronesi , eds. New York : Raven Press , 1992 . 296 pp., illus. $110. ISBN 0-88167-785 . Serono Symposia Publ. Vol. 79 LARRY C. CLARK, M.P.H., PH.D. LARRY C. CLARK, M.P.H., PH.D. Epidemiology Program University of Arizona Cancer Center2504 E. Elm St. Tucson, AZ 85716 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 1, 5 January 1994, Page 57, https://doi.org/10.1093/jnci/86.1.57 Published: 05 January 1994
The J-curve phenomenon and the treatment of hypertension. Is there a point beyond which pressure reduction is dangerous?
Authors: L. Farnett
Journal: JAMA (1991)

We critically appraised the medical literature to evaluate whether there is a point beyond which blood pressure reduction in hypertensive subjects is no longer beneficial and possibly even deleterious. Thirteen studies that stratified cardiovascular outcomes by level of achieved blood pressure in treated hypertensive subjects who had been followed up for at least 1 year were critiqued by four independent reviewers. Data addressing population, protocol, and methodological characteristics were evaluated. Studies did not show a consistent J-shaped relationship between treated blood pressure and stroke, but they did demonstrate a consistent J-shaped relationship for cardiac events and diastolic blood pressure. The beneficial therapeutic threshold point was 85 mm Hg. We conclude that low treated diastolic blood pressure levels, ie, below 85 mm Hg, are associated with increased risk of cardiac events. (<i>JAMA</i>. 1991;265:489-495)
MOTTLED ENAMEL
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lithium Salts
Authors: Edward G. Colbert
Journal: JAMA (1961)

<h3>To the Editor:—</h3> Your reference is drawn to the article on Lithium Salts, JAMA, Jan. 28, 1961. In this article your consultant, C. Wingard, M.D., states, "There are no therapeutic uses for lithium salts." It is important to note that here is a growing psychiatric literature on the use of lithium in mania. Kindly note the article, Lithium Ion: A Specific Psychopharmacological Approach to the Treatment of Mania (Samuel Gershon, M.B., B.S., D.P.M., and Arthur Yuwiler, Ph.D., Neuropsychiat 1: May-June, 1960). This article states, "Since 1949 Lithium therapy has been applied to 446 cases of mania. In the composite picture 84% of manic patients improved, many to the point of returning to their former positions in society." Several of my colleagues and I are using lithium in the treatment of a manic phase of manic depressive psychosis and find it to be an extremely valuable therapeutic agent. Plasma lithium levels
Dermatology
Authors: John Godwin Downing
Journal: New England Journal of Medicine (1959)

PsoriasisDespite the enormous research of modern dermatology, psoriasis remains the most baffling of dermatoses. The only worth-while advances in the past two centuries have been in diagnosis and supportive treatment. Many physicians, upon making a diagnosis of psoriasis, bluntly tell the patient that there is no cure, a statement true of almost every chronic disease. Instead, a hopeful attitude should be adopted. The patient should be given a frank description of the disease, including the proper treatment to keep it at a minimum and its tendency to relapse, and he should be helped to relieve the tension from which . . .
Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance
Authors: Karsten Sydow, Andreas Daiber, Matthias Oelze, Zhiqiang Chen, Michael August, Maria Wendt, Volker Ullrich, Alexander Mülsch, Eberhard Schulz, John F. Keaney, Jonathan S. Stamler, Thomas Münzel
Journal: Journal of Clinical Investigation (2004)

Recent studies suggest that mitochondrial aldehyde dehydrogenase (ALDH-2) plays a central role in the process of nitroglycerin (glyceryl trinitrate, GTN) biotransformation in vivo and that its inhibition accounts for mechanism-based tolerance in vitro. The extent to which ALDH-2 contributes to GTN tolerance (impaired relaxation to GTN) and cross-tolerance (impaired endothelium-dependent relaxation) in vivo remain to be elucidated. Rats were treated for three days with GTN. Infusions were accompanied by decreases in vascular ALDH-2 activity, GTN biotransformation, and cGMP-dependent kinase (cGK-I) activity. Further, whereas in control vessels, multiple inhibitors and substrates of ALDH-2 reduced both GTN-stimulation of cGKI and GTN-induced vasodilation, these agents had little effect on tolerant vessels. A state of functional tolerance (in the GTN/cGMP pathway) was recapitulated in cultured endothelial cells by knocking down mitochondrial DNA (ρ0 cells). In addition, GTN increased the production of reactive oxygen species (ROS) by mitochondria, and these increases were associated with impaired relaxation to acetylcholine. Finally, antioxidants/reductants decreased mitochondrial ROS production and restored ALDH-2 activity. These observations suggest that nitrate tolerance is mediated, at least in significant part, by inhibition of vascular ALDH-2 and that mitochondrial ROS contribute to this inhibition. Thus, GTN tolerance may be viewed as a metabolic syndrome characterized by mitochondrial dysfunction.
Reply
Authors: R. E. Woodrough
Journal: British Journal of Dermatology (1977)

Journal Article Reply Get access R. E. Woodrough R. E. Woodrough Clinical Biophysics, Department of Medical Electronics, Saint Bartholomew's Hospital, London EC1A 7BE Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 96, Issue 5, 1 May 1977, Pages 573–574, https://doi.org/10.1111/j.1365-2133.1977.tb07167.x Published: 01 May 1977
Rheumatologic symptoms can occur in histoplasmosis
Authors: P. Gunby
Journal: JAMA (1980)

Nearly 7% of one patient group treated during Indianapolis' 1978-1979 histoplasmosis outbreak had rheumatologic manifestations, such as arthritis, arthralgia, or erythema nodosum. In reporting this to the American Rheumatism Association section at the Arthritis Foundation's annual meeting in Atlanta, Indiana University Medical Center investigators noted: "In most patients, the rheumatologic manifestations were sufficiently mild as to require no therapy or only salicylates or other nonsteroidal anti-inflammatory drugs. However, three patients were given prednisone." The Indianapolis outbreak claimed 15 lives. Before it subsided, 435 histoplasmosis cases were confirmed serologically. The source never was found (<i>JAMA</i>[MEDICAL NEWS] 1979;242:1010 and 1980;243:1130). The investigators—Jerome Rosenthal, MD, Kenneth D. Brandt, MD, Lawrence J. Wheat, MD, and Thomas G. Slama, MD—obtained their information from a review of the records of 381 patients "with symptomatic histoplasmosis infections" seen during the outbreak. Twenty-four (6.6%) of these patients had rheumatologic problems: Sixteen had joint pain without swelling (classified
Commentaire de travail de P. R. de Reuver et al., pp. 637
Journal: Endoscopy (2008)

See also: Impact of bile duct injury after laparoscopic cholecystectomy on quality of life: a longitudinal study after multidisciplinary treatmentEndoscopy 2008; 40(08): 637-643DOI: 10.1055/s-2008-1077444
Hepatitis B in a prenatal population
Authors: W. M. Dankner
Journal: JAMA (1993)

<h3>To the Editor.</h3> —We read with interest the article by Silverman et al<sup>1</sup>in the November 27, 1991, issue of<i>JAMA</i>. The authors found a high rate of hepatitis B surface antigen (HBsAg) positivity (6.7%) among their unregistered prenatal population. Positivity was highly correlated with positive urine drug test results. They recommended initiating hepatitis B virus (HBV) prophylaxis to neonates born of unregistered mothers, especially those with positive drug-test results. At the University of California San Diego Medical Center, with an average of about of 4000 deliveries per year, 25% to 30% of women present with no prenatal care. Included in the battery of tests for these women are HBsAg and urine drug screening. In order to compare our population with that of Silverman et al, we reviewed similar demographic, laboratory, and clinical data from our unregistered patients for one calendar year. In 1990 there were 3981 deliveries of
The study of trauma
Authors: T. J. Poulton
Journal: JAMA (1979)

<h3>In Reply.—</h3> Emergency care physicians, anesthesiologists, physiologists, physical therapists, and even psychiatrists can all be helpful in improving the care of the severely injured. Despite all that assistance, the final "buck stops here"—with the surgeon. The more groups that can be involved in regional appraisals, the better.
THE COUNTRY DOCTOR.
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blood Disorders in Children
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pathfinders in Medicine.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pentamidine aerosol versus trimethoprim-sulfamethoxazole for Pneumocystis carinii in acquired immune deficiency syndrome.
Authors: A B Montgomery, D W Feigal, F Sattler, G R Mason, A Catanzaro, R Edison, N Markowitz, E Johnson, S Ogawa, M Rovzar
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Pneumocystis carinii pneumonia remains one of the most common opportunistic infections in patients with acquired immune deficiency syndrome (AIDS). Treatment with either intravenous pentamidine or trimethoprim-sulfamethoxazole (TMP-SMX) is frequently complicated by serious adverse reactions. This study was a prospective, blinded comparison of 600 mg/d of pentamidine as an aerosol versus 15 mg/kg/d of trimethoprim plus 75 mg/kg/d of sulfamethoxazole for patients with mild or moderately severe P. carinii pneumonia (alveolar arterial oxygen difference of less than 55 mm Hg). Of 367 participants who were randomized to receive study therapies, 287 had proven and 16 had presumed Pneumocystis pneumonia. There were 29 deaths within 35 d of study initiation: 12 in the aerosolized pentamidine group and 17 in the TMP-SMX groups (log rank p = 0.28). The difference in mortality was 3.4% (95% CI = -3.5, 10.8%). Ninety-four patients treated with aerosolized pentamidine had to have their study therapy changed because of lack of efficacy, compared with 22 patients treated with TMP-SMX (p = 0.002). In addition PaO2 improved faster in patients treated with TMP-SMX. However, aerosolized pentamidine was discontinued less often than TMP-SMX because of toxicity (9.4 versus 40% p < 0.001). Rash (0.6 versus 14.9%), nausea and vomiting (1.7 versus 12.2%), and abnormalities of liver function tests (1.7 versus 12.2%) were the most common adverse effects necessitating treatment discontinuation. During 6-mo. follow-up there was no difference in mortality.(ABSTRACT TRUNCATED AT 250 WORDS)
Mediastinal lymphadenopathy in infectious mononucleosis. Report of two cases
Authors: T. Rosenthal
Journal: JAMA (1975)

ENLARGEMENT of lymph nodes in the neck almost invariably forms an integral part of the clinical features of infectious mononucleosis. When the lymphadenopathy is accompanied by sore throat and splenomegaly, the diagnosis of infectious mononucleosis is quite likely, but must be confirmed by specific laboratory examinations. The fact that<i>mediastinal lymph nodes</i>can be involved in this disease may be overlooked by the internist, since many patients with infectious mononucleosis do not have chest xray films taken. This article describes two patients with proved mononucleosis in whom marked mediastinal lymphadenopathy developed during the course of their disease. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 20-year-old soldier was admitted with sore throat, cough, and abdominal pain. Physical examination disclosed bilaterally enlarged cervical glands and mild hepatosplenomegaly. Laboratory data included a white blood cell count of 14,300/cu mm with 71% lymphocytes, most of them atypical. A chest x-ray film showed widening of the
The Biology of Tissue Transplantation
Authors: Paul S. Russell, Anthony P. Monaco
Journal: New England Journal of Medicine (1964)

ThymectomyAlthough there are many hints in the old literature pointing toward an immunologic role for the thymus, a significant area of transplantation biology was opened by Miller's304 announcement of a profound impairment in the immunologic development and capacity of mice thymectomized at birth. Similar observations in mice were made independently by Martinez et al.305 and by Trentin306 and in rats by Arnason and his colleagues.307 , 308 Thymectomy, performed at a propitious time, has profound effects on the health, longevity and immunologic status of animals. Whereas thymectomy performed at three weeks in many mouse strains has few untoward effects,309 in neonatally . . .
Nephric Narcissism
Authors: Samuel Vee
Journal: JAMA (1971)

<h3>To the Editor.—</h3> The credibility chasm between painting and title has attained unprecedented width in the "Teenager Kidney Admires Itself in the Mirror" onThe Journalcover of the Oct 26th issue. Just why the depicted object should qualify as a kidney rather than a split bean in an overcooked soup or the clipped wings of an Amazonian butterfly (<i>Lepidopter manitobensis</i>) remains a mystery. And—if a kidney —why "teenager" rather than "octogenarian"? Even more perplexing is the arrant nephric narcissism. We can understand the vanity of a "gutsy" bowel, a "seminal" testis, a "brave" heart, or a "meditative" oft-"vented" spleen, but renal self-admiration is anthropomorphism running wild.
History
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Computed cranial tomography in acoustic tumor diagnosis
Authors: M. L. Wong
Journal: JAMA (1981)

With the development of computed cranial tomography (CCT), many physicians have come to rely on this technique as their sole means of excluding a diagnosis of acoustic neurinoma. In our series of 237 patients with acoustic tumors, 29% of tumors were not detected by CCT. New thin-section scanners improve this detection rate. Tumors within the internal auditory canal, however, will not be detected without special techniques. We recommend that contrast studies of the posterior fossa be employed to exclude definitely the diagnosis of acoustic tumor when one is suspected. (<i>JAMA</i>1981;245:2497-2500)
Academic and professional freedom.
Journal: BMJ (1969)

In his Harveian oration on " Medical Educaition and the State " Pro- fessor Ronald Christie analyses the conditions for keeping academic and professional freedom (p.385).Leader at this page.Epidemiology of Urinary Disease: A one-year survey from general practice in Denmark of morbidiity from urinary disease at different ages and by sex (p.390).Leader at p. 381.Therapeutic Abortion: All four techniques used for termination caused feto-maternal haemor- rhage, though under 12 weeks the incidence was very small (p.395).Maturity-onset Diabetes: Study suggests that development of insulin insensitivity may precede appearance of vascular disease (p.397).Angina Pectoris : Mode of action of /3-adrenergic receptor blocking agents (p.399).Hypokalaemia and Hypophosphataemia: It is suggested that there may be a causal relationship, which in chronic potassium depletion may result in osteomalacia (p.402).Oral Contraceptives: Relapse of Sydenham's chorea apparently asso-ciated with taking of oral contraceptives (p.404).Leader on relationship to depression (p.380).Acute Leukaemia: Controlled trial of whooping- cough vaccine as a non-specific antigen to pro- long remissions after chemotherapy (p.406).Tetracosactrin (Synaethen): Absorbed nasally (p.407).Statement by manufacturer (p.441).Transient Hypertension: Segmental occlusion of renal artery (p.408).
Sequelae of Arnold-Chiari Malformation
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tunnelated peritoneal catheter versus large volume paracentesis for refractory ascites in cirrhosis: a randomized controlled trial
Authors: Nina Kimer, Agnete Riedel, Lise Hobolth, Christian Mortensen, Mette Lehmann Andersen, Frank Vinholt Schiødt, Lone Madsen, Søren Møller, Lise Lotte Gluud
Journal: Journal of Hepatology (2020)