tbuckley/cabot-search huggingface dataset:
Markers of HIV infection prior to IgG antibody seropositivity
Authors: S. L. Stramer
Journal: JAMA (1989)

During a 1-year period of study at two plasma collection centers, 7 of 35 000 plasma donors seroconverted to the human immunodeficiency virus (HIV) and had stored plasma samples that predated or antedated the seroconversion period. From each donor, three to eight plasma samples that had been collected at 2- to 7-day intervals were tested for IgG and IgM antibodies to HIV with enzyme immunoassays, Western blot testing, and radioimmunoprecipitation assays. The presence of an HIV viremic phase was demonstrated by the infectivity of plasma on normal, phytohemagglutinin-stimulated peripheral blood mononuclear cells and by the detection of HIV antigen. In 5 of these donors, HIV antigen was detected prior to or simultaneously with IgG to HIV; these HIV-antigen—positive samples overlapped an IgM immune response. The disappearance of detectable HIV antigen, and to a lesser extent plasma infectivity, was concurrent with the development of an IgG immune response. Although the improved sensitivity of a recombinant DNA-derived anti-HIV screening assay shortened the "window period" between initial HIV infection and antibody detection, HIV antigen and plasma HIV viremia were the only markers of HIV infection for several days in 2 donors. These results demonstrate that HIV plasma viremia and antigenemia occur prior to seroconversion in healthy plasma donors. (<i>JAMA</i>. 1989;262:64-69)
PUBLIC. HEALTH.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stenosis of Hepatic Duct in Lithiasis of Neck of Gallbladder and of Cystic Duct (Mirizzi Syndrome)
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transplantation Today
Authors: Robert E. McCabe
Journal: JAMA (1971)

In such a rapidly expanding field as transplantation, it is essential for both investigators and clinicians to assemble annually to disseminate knowledge and to discuss mutual problems. At the Third International Congress, a four-day meeting held at The Hague in early September 1970, a total of 247 contributions from multiple world wide institutions were presented. These dealt with the most current problems in transplantation, including organ preservation and sharing, transplantation biology and immunology, methods of inducing tolerance to grafted tissue, or enhancement, newer methods of immunosuppression, the efficacy of antilymphocyte globulin (ALG) and its preparation and assay. Although clinical interest has centered primarily on the kidney as a transplantable organ, there is considerable investigative interest in all other organs as well as cross species transplants or xenografts. This voluminous material, all in English, will be new to many but familiar to others. It has been aptly assembled by the editors
From the Centers for Disease Control. FDA approval of second diphtheria, tetanus toxoids, and acellular pertussis vaccine
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Glaucoma Gene
Authors: Tracy Hampton
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ALLEGED RELATION BETWEEN ALKALOSIS AND TETANY
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypnosis
Authors: J. A. Hall
Journal: JAMA (1978)

WHEN a patient or friend asks about the medical use of hypnosis, he may have heard about it on television, may have talked with a friend who had hypnotic treatment, or may have witnessed a party stunt. The question may indicate his suspicion that there is an important psychosomatic component in his complaint, and he hopes that hypnosis can change things in his mind or body without the time, pain, and money required by more conventional treatment. He may see hypnotherapy as magic, a fantastic expectation that is often projected into this frequently misunderstood technique. When a patient asks about hypnosis, first ascertain if some unspoken concern lies behind his question. Then reassure him that in the proper hands, hypnotherapy can be an acceptable treatment. Hypnotherapy has been recognized by the American Medical Association, the British Medical Association, and the American Psychological Association, as well as other professional groups. However,
Hepatic resection following rescue cetuximab treatment for colorectal liver metastases previously refractory to conventional systemic therapy
Authors: T. Aloia, F. Levi, D. A. Wicherts, R. J. Haas de, B. Paule, M. Bralet, M. Bouchahda, D. Azoulay, D. Castaing, R. Adam
Journal: Journal of Clinical Oncology (2007)

4061 Background: The impact of cetuximab-containing chemotherapy on resectability of previously unresectable colorectal liver metastases (CLM) is unknown, especially in patients resistant to first-line chemotherapy. This study was performed to determine the cetuximab resectability rate, and to examine the outcomes of these heavily pretreated patients after hepatic resection. Methods: From February 2004 to April 2006, we evaluated 151 patients with unresectable CLM resistant to initial chemotherapy and subsequently treated with cetuximab-containing regimens. 133 patients (88%) were completely treated at our institution and 18 patients (12%) received systemic therapy elsewhere. Resectability rates, perioperative outcomes, survivals, and histopathological analysis of the tumoral and non- tumoral liver were assessed. Results: 27 patients were operated after a median of 6 cycles of cetuximab + irinotecan (20/27), oxaliplatin (4/27), or both (1/27). 18 of these patients (67%) had failed at least 2 lines of prior chemotherapy. 25 patients underwent hepatectomy, including 9 of 133 patients completely treated at our institution (resectability rate: 7%) and 16 of 18 referred patients. Postoperative mortality was 3.7% (1/27), with a complication rate of 50%. Complete tumor necrosis was observed in 2 patients (8%). Histopathological liver abnormalities were found in 9 patients (36%), without any specific lesion related to cetuximab. After a median follow-up of 16 months (range 6–39), all but one resected patients were alive, 10 of whom were disease-free. Conclusions: For CLM refractory to conventional chemotherapy, combination chemotherapy with cetuximab significantly increased resectability rates with no appreciable increase in operative mortality or liver injury. Longer follow-up is awaited to confirm the encouraging results of this new oncosurgical strategy. No significant financial relationships to disclose.
ADDRESS ON AN EXHIBIT OF EARLY (PRIOR TO 1860) BRITISH AND AMERICAN OPHTHALMIC LITERATURE.
Authors: CASEY A. WOOD
Journal: JAMA (1902)

Two years after the publication in Philadelphia of Saunder's work, there appeared the first text-book by an American writer, George Frick. We owe most of our knowledge of this pioneer of American ophthalmology to our distinguished colleague, Harry Friedenwald. I quote from his interesting contribution to the<i>Johns Hopkins Hospital Bulletin</i>for August-September, 1897, "The Early History of Ophthalmology and Otology in Baltimore." Frick was born in Baltimore in 1793. After obtaining a broad classical education he entered the University of Pennsylvania, where he obtained the degree of doctor of medicine in 1815, and in 1817 he was admitted as licentiate of medicine into the Medical and Chirurgical Faculty of Maryland. He then spent several years abroad, returning to Baltimore about 1819 to engage in the practice of ophthalmology. He was appointed surgeon to the Baltimore General Dispensary, where he established the first Eye Dispensary in Baltimore, in 1824. In
What Does Your Child Weigh?
Journal: JAMA (1924)

chapters in the work.In the chapter on drugs, the only official preparations mentioned are those in the United States Pharmacopeia.No mention is made of British Pharmacopeia preparations.The Canadian reader would have to know whether the preparations of the two pharmacopeias were of same strength before following the dosage given.We cannot but admire the author's outspoken opinion of the worthlessness of many of the vaccines, serums, ductless gland substances and other preparations foisted upon the profession by pharmaceutical houses.It would appear to be a safe general guide in outlining methods of treatment.The therapy of specific diseases is that generally followed by the author in his own practice and appears to be based on sound observation.J. H. E.
Oxygen regulates the expression of aldolase A, glyceraldehyde-3-phosphate dehydrogynase and the glucagon-dependent induction of the phosphoenolpyruvate carboxykinase gene via a heme protein mediated mechanism in hepatocytes Institut f�r Biochemie und Molekulare Zellbiologie, Humboldtallee 23, D-37073 G�ttingen, Germany
Journal: Hepatology (1995)
Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression
Authors: Masaki Ieda, Keiichi Fukuda, Yasuyo Hisaka, Kensuke Kimura, Haruko Kawaguchi, Jun Fujita, Kouji Shimoda, Eiko Takeshita, Hideyuki Okano, Yukiko Kurihara, Hiroki Kurihara, Junji Ishida, Akiyoshi Fukamizu, Howard J. Federoff, Satoshi Ogawa
Journal: Journal of Clinical Investigation (2004)

The cardiac sympathetic nerve plays an important role in regulating cardiac function, and nerve growth factor (NGF) contributes to its development and maintenance. However, little is known about the molecular mechanisms that regulate NGF expression and sympathetic innervation of the heart. In an effort to identify regulators of NGF in cardiomyocytes, we found that endothelin-1 specifically upregulated NGF expression in primary cultured cardiomyocytes. Endothelin-1–induced NGF augmentation was mediated by the endothelin-A receptor, Giβγ, PKC, the Src family, EGFR, extracellular signal–regulated kinase, p38MAPK, activator protein-1, and the CCAAT/enhancer-binding protein δ element. Either conditioned medium or coculture with endothelin-1–stimulated cardiomyocytes caused NGF-mediated PC12 cell differentiation. NGF expression, cardiac sympathetic innervation, and norepinephrine concentration were specifically reduced in endothelin-1–deficient mouse hearts, but not in angiotensinogen-deficient mice. In endothelin-1–deficient mice the sympathetic stellate ganglia exhibited excess apoptosis and displayed loss of neurons at the late embryonic stage. Furthermore, cardiac-specific overexpression of NGF in endothelin-1–deficient mice overcame the reduced sympathetic innervation and loss of stellate ganglia neurons. These findings indicate that endothelin-1 regulates NGF expression in cardiomyocytes and plays a critical role in sympathetic innervation of the heart.
Saint Thomas Hospital Reports.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medicine as a monopoly.
Journal: BMJ (1970)

PointersNew Review Body: Statement by Minister (p.377).Leader at p. 322.Phenylbutazone Metabolism: Shown in man to be genetically controlled in a similar manner to body height.Knowledge should lead to improved therapeutic efficacy (p.323).Insulin Secretion: Importance of the autonomic nervous system in controlling' insulin secretion in normal subjects and in patients with severe heart failure (p.328).Glucose Tolerance: Glucose tolerance tests in 122 men over 40 showed significant diurnal variation, with afternoon test giving the highest blood levels.Degree of variation inversely related to obesity (p.334).Cromoglycate in Exercise Asthma: Exercise- induced asthma in adults reduced significantly by inhaling disodium cromoglycate before exer- cise (p.337)."Sicca Complex" in Liver Disease: Study of 63 patients with liver disease suggests that sicca complex and autoimmune liver disease may be part of an immunologically based systemic dis- order (p.340).Oxprenol and Practolol Trials: Both beta-adrenergic blocking drugs caused non-postural fall in blood pressure.Clinically adequate reduction in less than half of patients (p.342).Medical Memoranda: Antagonism of hypoten- sive action of bethanidine by "common cold" remedy, Ornade (p.347); Vasovagal faint in supine position (p.348); "Idiopathic" lactic acidosis (p.348).
Correction
Journal: BMJ (1964)

9NMay 1964 Any Questions ?MWDITJMRNoAu genetic predisposition is suggested by the higher incidence of a history of chronic bronchitis in relatives of patients with this disease than in relatives of unaffected indi- viduals.The abnormality in the bronchial mucosa appears to predispose to persistence of common respiratory infections.It is possible that frequently recurrent respiratory infections may themselves be a factor in the development of the underlying bronchial mucosal abnormality.There is good evidence that damage in the peripheral part of the bronchopulmonary tree caused by bacterial infection is at least an important factor in the gradual development of permanent disability.This matter is dealt with at length in the monograph of chronic bronchitis edited by N. C. Oswald.2
American Society of Nephrology (ASN) 29th annual meeting. New Orleans, Louisiana, November 3-6, 1996. Abstracts.
Journal: Journal of the American Society of Nephrology (1996)

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Reference Committees 1985 Annual Meeting
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CORTISONE AND ACTH IN ALOPECIA AREATA AND TOTALIS
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal