tbuckley/cabot-search huggingface dataset:
Evaluation of a New Ovulatory Stimulating Agent
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
About the Cover
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alloplasty in Surgery of the Eye
Authors: William Stone
Journal: New England Journal of Medicine (1958)

Invagination of the Upper LidIt was pointed out in the preceding section that one of the primary reasons for a poor cosmetic appearance after the removal of an eye is not only the immobility of the prosthesis but also the sinking in or invagination of the upper lid. This is caused by a falling back and redisposition of the tissues, mostly fat, which originally resided behind the upper lid, in the upper portion of the orbit. If an implant is of sufficient volume and held securely in the proper position in the orbit, the sinking in of the upper . . .
Understanding Cardiology.
Journal: Annals of Internal Medicine (1979)

This method of presentation means that difficult to get an overall picture of a disea For example, the changes found in hyperti monary oesteoarthropathy may be found se the sections on the foot, the hand, and knee, b is there an overall description of the condil sequently one is left with the impression tha monest changes are a periostitis of the bc hand and feet, and the more common perio: forearms and ankles is not stressed.Similarly
The anti–PD-1 antibody spartalizumab (S) in combination with dabrafenib (D) and trametinib (T) in previously untreated patients (pts) with advanced <i>BRAF</i> V600–mutant melanoma: Updated efficacy and safety from parts 1 and 2 of COMBI-I.
Authors: Georgina V. Long, Celeste Lebbe, Victoria Atkinson, Mario Mandalà, Paul D. Nathan, Ana Arance, Erika Richtig, Naoya Yamazaki, Caroline Robert, Dirk Schadendorf, Hussein Abdul-Hassan Tawbi, Paolo Antonio Ascierto, Antoni Ribas, Keith Flaherty, Dung-Yang Lee, Aisha Masood, Eduard Gasal, Reinhard Dummer
Journal: Journal of Clinical Oncology (2020)

57 Background: Checkpoint inhibitors and targeted therapies have improved outcomes in pts with BRAF V600–mutant advanced melanoma; however, many pts progress and new treatment (tx) strategies are needed. BRAF inhibition increases T-cell infiltration, melanoma antigen expression, and PD-1/PD-L1 expression, which may lead to synergistic activity with anti–PD-1 therapy. Methods: COMBI-i is investigating first-line S 400 mg Q4W + D 150 mg BID + T 2 mg QD in pts with unresectable or metastatic BRAF V600–mutant melanoma (NCT02967692). Here we report pooled efficacy and safety data from parts 1 (run-in cohort) and 2 (biomarker cohort). Response was assessed per RECIST v1.1. Results: 36 pts were enrolled (part 1: n = 9; part 2: n = 27); 18 (50%) had stage IV M1c and 15 (42%) had elevated LDH levels. At the data cutoff (median follow-up, 15.2 mo), tx was ongoing in 17 pts (47%). The confirmed objective response rate (ORR) by investigator assessment was 75% (n = 27), with 33% complete responses (CRs; n = 12). Medians for duration of response (DOR; 7/27 pts with events), progression-free survival (PFS; 13/36 pts with events), and overall survival (OS; 7/36 pts with events) were not reached. 12-mo DOR rate was 71.4% (95% CI, 49%-85%). 12-mo PFS and OS rates were 65.3% (95% CI, 47%-79%) and 85.9% (95% CI, 69%-94%), respectively. In pts with high baseline LDH: ORR was 67%, with 3 CRs (20%), median PFS was 10.7 mo (events in 10/15 pts [67%]), and median OS was not reached, with events in 6/15 pts (40%). All pts had ≥ 1 AE; 27 (75%) had grade ≥ 3 AEs. 6 pts (17%) had AEs leading to discontinuation of all 3 study drugs. Any-grade AEs in ≥ 40% of pts included pyrexia, chills, fatigue, cough, and arthralgia. Grade ≥ 3 AEs in &gt; 3 pts were neutropenia, pyrexia, and increased lipase. One pt died of cardiac arrest that was not considered related to study tx. Conclusions: S+D+T showed promising and durable ORR (75%) with CR in 33% of pts. With &gt; 15 mo of follow-up, median PFS was not reached. The safety profile was manageable reflecting individual toxicities of D, T, and S. The global, placebo-controlled, randomized phase 3 (part 3) of COMBI-i is ongoing. Clinical trial information: NCT02967692.
Radioisotope Placenta Scanning For Feto-Maternal Abnormalities
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Howard Rusk, MD: an equal chance
Authors: N. Yanes-Hoffman
Journal: JAMA (1981)

Although some people, Ronald Reagan among them, call Howard Rusk "The Father of Rehabilitation Medicine," he declines that honor. "Minnesota's Dr Frank Krusen deserves that title," he says. "He was far ahead of me. He succeeded in getting the AMA to recognize physical medicine as a specialty when most doctors made no bones about brushing it off as a `social service boondoggle'." Rusk<i>will</i>admit, however, to being "father, midwife, and pediatrician" to the modern concept of rehabilitation, the radical who argued that physicians should treat the "whole person," not just the ring finger or the toe. At 80, Howard A. Rusk, MD, a Nobel Peace Prize nominee in this Year of the Disabled, embodies the best of America. With his native American optimism, his tinker-repairer tradition, and his quirks, Rusk also incorporates some of America's questions about itself: What are society's responsibilities to the individual? What do we mean
THC: "transitional drug' for emesis therapy?
Authors: C. Macek
Journal: JAMA (1982)

Even after years of clinical and laboratory trials, the jury is still out on the health effects of marijuana. That was the consensus of a panel of experts who reviewed the morass of scientific literature on cannabinoids for the National Academy of Sciences' report<i>Marijuana and Health</i>, released in late February. Although a variety of short-term effects were evident to panel members, they were unable to make conclusions about how prolonged use of the drug would affect health and thus recommended "a greatly intensified and comprehensive program of research." Similar recommendations and conclusions were reached by Britain's Advisory Council on the Misuse of Drugs in a report released in March. True enough, US support of research has been sparse (about $4 million a year) on this, the most widely used illegal drug in the country. But the fact is that because of marijuana's known efficacy as an antiemetic, it has,
Methylmercury in Fish: A Review of Residue Levels, Fish Consumption and Regulatory Action in the United States
Authors: Linda Tollefson, Frank Cordle
Journal: Environmental Health Perspectives (1986)

The dangers associated with the consumption of large amounts of methylmercury in fish are well recognized, and there is some evidence to suggest that methylmercury may be the cause of subtle neurological impairments when ingested at even low to moderate levels, particularly the prenatal and early childhood periods. This concern has prompted a continuing assessment of the risk of methylmercury toxicity among fish consumers in the United States as well as other countries. The toxicokinetics of methylmercury in humans are reviewed and used to estimate body burdens associated with toxic effects. To determine seafood consumption patterns among the continental U.S. population the Food and Drug Administration (FDA) has analyzed data from a diary study commissioned by the Tuna Research Foundation. Mercury residue levels in domestic fish sampled by the FDA were used to determine the level of exposure to methylmercury. Until evidence is presented that substantially lowers the known body burden of methylmercury which causes toxicity, calculations indicate that the current 1.0 ppm regulatory level provides adequate protection for the average fish consumer, for young children, and for a significant number of consumers exceeding the acceptable daily intake. However, additional studies are being carried out in a continuing process to ensure that safe levels of prenatal exposure to mercury residues in fish are maintained.
Editorial Board
Authors: Samuel Didier, Christoph Co-Editors, Peter Day, Paolo Angeli, Marina Berenguer, Thomas Spain, France Baumert, Pierre-Ala In Clavien, Swit Zerland, Jean-F Ranc ¸ois Dufour, Ira Jacobson, Ansgar Lohse, Derek Mann, Philippe Mathurin, France Vincen, Ma Zzaferro, Jorg Petersen, Vlad Ra, Fran Ce, Robert Schwab, Stefan Zeuzem, Scott Friedman, Danie Shouval, Detlef Schu, Graeme Alexander, Patric Marcellin, France Llovet, Sheila Sherlo, Foun Ding, Simona Negrini, Joe ¨l Walic, D Abraldes, Spain Juan, Israel Zvi, Simon Afford, U Alberti, Ita Ly Angulo, Usa Paul, Quentin Anstee, U Avila, Spain Bedossa, France Ben-Ari, Israel Ziv, Antonio Berg, Singapore Beuers, Jean-Pi Erre, Fra Nce Bruix, Spain Jordi, Patrizia Burra, Italy Burroughs, U Buti, Ma Ria, Spain Caldwell, Usa Stephen, Germany Diego, Fra Laurent, Helena Nce Cortez-Pinto, Anton Io, Italy Dalekos, Greece Georgious, Ma Dandri, Lia Austra, Jean-Charles Duclos-Vallee, Fra Nce Duvoux, Christop He, Fran Ce Factor, Geoff Farrell, Ralia Aust, Ariel Feldstein, Usa Felipo, Spain Fickert, Ria Peter, Alejandro Forner, Spain Forns, Garcia-Paga Xavier, Ju ´n, Garcia-Tsao Spain, Usa Geier, Tim Greten, Usa Gustot, Belgium Hadengue, Swit Zerland Heathcote, Canada Heim, Swit Zerland Hoshida, Usa Yujin, Harry Janssen, The La, Ands Netherl, Zakiyah Kadry, Usa Kaneko, Japan Shuichi, Jia-Ho Kao, Taiwan Rng, Usa Neil, Sau Karpen, Usa Lampertico, Italy Lau, China Lebrec, France Lencioni, Italy Locarnini, Germany Volker, Anna Lok, Usa Lotersztajn, Fran Sophie, Lu Ce, Pietro Tom, Swit Zerland Mann, Ma Nns, Mic Hael P, Germany, Ma Rchesini, Ma Rra, Ma Rschall, Sweden Ma, Mie Li-Vergani, U Giorgina, U Negro, Fiona Oakley, U Oben, Usa O'grad, Oude Elferink, Georg Es-Philippe, Stephen Pianko, Sal Erno, Fran Cesco, Ita Ly Sal, Stick El, U Simon, Tillma Nn, Usa Hans, Trautwe In Tong, Trott Er, Usa Valla, Dominiq Ue, Fran Ce Verga, Taiwan Zars, Fra Nce, Zuc Kerman, Mark Thursz, Markus Peck-Radosavlj Evic, Austria, Mauro Bernardi, Spain Avila, Germany Lamm, V George, Daniele Pa Patheodoridis, Greece, Laurent Prati, Fran Castera, Jean-Fr Anc ¸ois Dufour, Fabien Zoulim, Ital Burra
Journal: Journal of Hepatology (2013)
Vasectomy and Increased Risk of Prostate Cancer
Authors: Daniel W. Cramer
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Concern about recent studies linking vasectomy and prostate cancer has been tempered by the absence of any clear biologic rationale for the association. In dismissing as unlikely a role for hormonal mechanisms, Giovannucci et al<sup>1</sup>have overlooked evidence that may be linked to prostate cancer by disrupting gametogenesis and increasing gonadotropins. This mechanism is similar to that proposed for ovarian cancer,<sup>2</sup>which may share other epidemiologic features with prostate cancer. Experimental studies show that ligation of the vas causes Sertoli cell damage and Leydig cell hypertrophy. Seventy years ago, Steinach<sup>3</sup>recognized this effect in men and proposed vasoligation to rejuvenate aging men after observing that it produced "a cycle of growth... of the male generative gland" by causing "the expansion of the interstitial tissue at the expense of the generative tissue." Sertoli cell damage may decrease inhibins with a consequent increase in follicle-stimulating hormone.
The care of patients at increased risk of premature pacemaker failure
Authors: L. B. McGuire
Journal: JAMA (1979)

During 1975 to 1977, a series of advisory notices from a pacemaker manufacturer alerted us to an increased probability of sudden, premature pacemaker failure in 217 patients. Three possible responses to these recalls were used among these patients: prophylactic pulse generator change, increased surveillance without pulse generator change, and routine surveillance with replacement only after pacing failure. During the three years after implantation of these pulse generators, 30 sudden failures and 19 incidents of rate decrease indicating impending failure were observed; all were corrected by pulse generator replacement. Among the 50 deaths were six for whom terminal pacemaker status information was inadequate, but overall mortality was not notably different from other pacing series. Consideration of recalls should include projected frequency of failure, expected mode of failure, patient dependence on pacing, and presence of coexisting diseases. (<i>JAMA</i>241:701-703, 1979)
Corticosteroids for Patients With Septic Shock
Authors: Djillali Annane, Véronique Sebille, Eric Bellissant
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Poisoning by a malathion-xylene mixture
Authors: S. Gitelson
Journal: JAMA (1966)

DIAGNOSTIC difficulties may arise in cases of severe poisoning when the nature of the poison is unknown and the information available about the circumstances of the poisoning inadequate or even misleading. An illustrative case of malathion-xylene poisoning masquerading as chlordane-kerosene intoxication follows. <h3>Report of a Case</h3> An unconscious 17-year-old boy was brought to the hospital at midnight from a nearby settlement with an accompanying note from a physician stating that the boy had drunk an insecticide (a 2% solution of chlordane in kerosene [Flit]). On admission he was deeply comatose. Muscular rigidity and opisthotonos alternating with generalized clonic convulsions were seen at intervals. Some foamy secretion was present at the mouth, but there was no sweating or lacrimation, and no fasciculations were observed. Respiration was labored, and wheezing was heard over the chest. His gaze wandered, and the pupils were pinpoint. The pulse rate was 100 beats per minute, and
Clinical gastroenterology 4th Edition. By H. M. Spiro and co-authors C. E. Atterbury, K. W. Barwick, F. Gorelick, J. D. Gryboski, C. R. Kapadia, A. Reuben, M. Traube, R. K. Zeman, U. Sundaram and P. Marignani, 1,297 pp. New York: McGraw-Hill, 1993. $139
Authors: E Schimmel
Journal: Hepatology (1994)
Therapist Affect Focus and Patient Outcomes in Psychodynamic Psychotherapy: A Meta-Analysis
Authors: Marc Diener
Journal: American Journal of Psychiatry (2007)

Objective: The authors systematically examined the relationship between therapist facilitation of patient emotional experience/expression and outcome in psychodynamic psychotherapy. Method: Computer and manual searches were conducted for relevant publications, and 10 independent samples of short-term dynamic psychotherapy were included in a meta-analysis. Data analysis included calculation of an overall effect size of the relationship between therapist affect focus and outcome, statistical significance, and test for homogeneity. In addition, moderator analyses were conducted to examine the potential impact of type of outcome construct used and the methodological quality of individual studies. Results: The overall average weighted effect size across all outcome types was statistically significant (r=0.30), and the homogeneity statistic was nonsignificant. Moderator analyses indicated a statistically significant relationship between therapist facilitation of patient emotional experience/expression and outcome when more than one outcome construct was included but not when either a single or an unclear outcome construct was used. There were no significant relationships between methodological quality and the size of the effects, although use of audio- or videotaping for supervision demonstrated a moderate effect. Conclusions: These data indicate that therapist facilitation of patient affective experience/expression is associated with patient improvement over the course of psychodynamic psychotherapy. Although the size of this relationship was not significantly related to methodological quality, results suggest the importance of close supervision of actual techniques through the use of audio- or videotapes. Additionally, results highlight the importance of defining outcome in a multidimensional way to properly assess theoretically relevant effects.
Angewandte Paediatrie: Ein Nachschlag- und Lesebuch für Studierende und Arzte
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Drug Effectiveness Noted in Survival of Rats in Shock
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal