PB2469: PHS COMBINED WITH ENHANCED HYDRATION AND ALKALIZATION IN PATIENTS WITH DELAYED HEMORRHAGIC CYSTITIS OF GRADE I TO II AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATIONAPPLICATION RESEARCH
Authors: Hengrui Sun, Xiaoli Chen, LI Wang, Xinrong Yu, Xiaoqin Zhou, Yimei Feng, XI Zhang
Journal: HemaSphere (2023)

Topic: 22. Stem cell transplantation - Clinical Background: Hemorrhagic cystitis (HC) is a common serious complication in the treatment of hematopoietic stem cell transplantation (HSCT). The incidence rate varies from 5% to 40%, with an average of about 20%. At present, there is no specific drug to treat HC, and prevention is the main clinical treatment. Especially for the stage I to II of hemorrhagic cystitis, PHS combined with enhanced hydration and alkalization can significantly reduce the symptoms of patients such as frequent urination, urgency, pain in urination, hematuria, and effectively reduce the incidence of HC and the progression rate of HC patients from grade I to II to grade III to IV. Aims: To study the effect of PHS mode combined with enhanced hydration/alkalization scheme in patients with delayed hemorrhagic cystitis (HC) of grade I to II after hematopoietic stem cell transplantation. Methods: Thirty patients with hemorrhagic cystitis diagnosed after hematopoietic stem cell transplantation were randomly divided into two groups: experimental group and control group. The experimental group implemented PHS combined enhanced hydration scheme. The patients and their families were instructed to continue to strengthen drinking water>3000 ml/d, and the family members (P) were asked to use a visual food moisture meter to participate in the accurate recording of the amount of water in and out, and measured the first, second, third, fourth, and fifth days after sufficient drinking water, respectively At 7 time points on the 6th day, the number of urination per day, color, total volume, and urethral pain score. The intern nurses summarize the data every day, and the responsible nurse (H) enters the data. The intern nurse (S) is responsible for the telephone follow-up and record of the patient’s discharge follow-up for 3 months. The control group was given regular drinking water. In the absence of other physical, drug and other interventions, the time required to compare the number, color and total amount of urination per day of patients in the two groups to normal and the time required when the patient’s pain score is 0. Results: At 7 time points on the 1st, 2nd, 3rd, 4th, 5th and 6th day, the patients in the experimental group were lower than those in the control group in terms of the degree of relief of urethral pain, the incidence of urinary tract irritation and the occurrence of hemorrhagic cystitis grade III to IV, and the satisfaction and acceptance of patients in the experimental group were higher than those in the control group. The difference was statistically significant (P<0.05). No adverse complications occurred. Summary/Conclusion: PHS mode combined with enhanced hydration/alkalization scheme can improve the cure rate, reduce the occurrence of grade III to IV HC and increase the pain and massive bleeding caused by bladder spasm, alleviate the pain and suffering of patients, shorten the hospitalization time, improve the outcome and improve the quality of life of patients. Keywords: Hematopoietic cell transplantation