tbuckley/cabot-search huggingface dataset:
AB0312 BODY COMPOSITION AND BONE MINERAL DENSITY IN PATIENTS WITH RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS
Authors: O. Dobrovolskaya, A. Feklistov, N. Demin, A. Sorokina, O. Nikitinskaya, N. Toroptsova
Journal: Annals of the Rheumatic Diseases (2022)

Objectives To assess body composition and bone mineral density (BMD) in rheumatoid arthritis (RA) women compared to patients with osteoarthritis (OA). Methods 133 women with RA and 45 women with OA aged 50 and over were enrolled in the study. Body composition (fat mass (FM), lean mass and bone mineral component (BMC)) and BMD of the lumbar spine, femoral neck and total hip were measured using dual-energy X-ray absorptiometry (DXA). Appendicular muscle mass (AMM) and appendicular mass index (AMI) were calculated. Muscle strength was assessed in all patients. The criteria of the European Working group on Sarcopenia in Older people 2 (EWGSOP2) were used for low muscle mass and sarcopenia. Osteoporosis was determined in accordance with WHO criteria. Results Mean age of RA patients and women with OA was 61.3±7.1 and 61.9±6.2 years, respectively (p&gt;0.05). BMC and AMM were lower in RA patients than in women with OA: BMC - 1948.6±425.7g and 2167.1±398.1g, respectively (p=0.004); AMM - 17.5±2.9 kg and 20.1±2.7 kg, respectively (p&lt;0.001). 27 (20.3%) RA women and only 1 (2.2%) person with OA had low AMM (p=0.004). The mean value of AMI was 6.8±1.0 kg/m 2 and 7.5±0.9 kg/m 2 in RA and OA patients, respectively (p&lt;0.001). Total FM was 28.3±8.5 kg and 33.2±9.8 kg in RA and OA women, respectively (p=0.003). At the same time, we found no differences in the percentage of fat mass: 39.2±5.7% in RA patients and 39.9±5.8% in persons with OA (p&gt;0.05). Overfat was discovered in 99 (77.4%) and 38 (84.4%) in women with RA and OA, respectively (p&gt;0.05). All women with low AMM/AMI had low muscle strength and were diagnosed with confirmed sarcopenia. In RA patients BMD at any region was less than in women with OA: in the lumbar spine – 1.026±0.174 g/сm 2 and 1.114±0.177 g/сm 2 , respectively (p=0.009); in the femoral neck – 0.844±0.151 g/сm 2 and 0.914±0.137 g/сm 2 , respectively (p=0.005) and in the total hip 0.878±0.148 g/сm 2 and 0.986±0.117 g/сm 2 , respectively (p&lt;0.001). Normal BMD was found in 33 (24.8%) and 24 (53.3%) women with RA and OA, respectively (p=0.0004). 42 (31.6%) patients with RA and 6 (15.4%) women with OA had osteoporosis (p=0.017). Conclusion RA patients had lower BMC, AMM/AMI, total FM and BMD compared to women with OA, and they were significantly more likely to have sarcopenia and osteoporosis. Disclosure of Interests None declared
POS1369 PULMONARY ARTERY WALL THICKNESS IS INCREASED IN BEHÇET’S DISEASE
Authors: S. Kutluğ Ağaçkiran, M. Sunbul, D. Kocakaya, S. Kayaci, H. Direskeneli, F. Alibaz-Oner
Journal: Annals of the Rheumatic Diseases (2022)

Background Behçet’s Disease (BD) is a unique systemic vasculitis that mainly involves veins, in contrast to other vasculitides [1, 2]. Prior studies showed that pulmonary arteries have a similar structure with systemic veins in terms of wideness, thin-walled, increased compliance, and low resistance [3]. We have recently shown increased venous wall thickness in lower extremity veins of BD patients. Objectives In this study, we aimed to assess pulmonary artery (PA) wall thickness by transthoracic echocardiography (TTE) in BD compared to healthy controls and patients with non-inflammatory pulmonary embolism (NIPE). Methods Patients with BD (n=77), NIPE (n=33) and healthy controls (n=57) were included in the study. PA wall thickness was measured with TTE by a cardiologist blinded to cases. PA wall thickness was measured from the mid-portion of the main PA (approximately 1 to 2 cm distal to the pulmonary valve) as demonstrated in Figure 1. Figure 1. Measurement of pulmonary artery wall thickness by Transthoracic Echocardiography Results PA wall thickness was significantly lower in controls (0.36 mm (SD:0.03) compared to NIPE (0.44 mm (SD:0.05) and BD (0.44 mm (SD:0.06) (p&lt;0.001 for both). PA wall thickness was also found to be significantly higher in BD patients with major organ involvement (0.47 mm (SD:0.04) compared to healthy controls and NIPE (p &lt;0.001 and p=0.006, respectively). PA wall thickness was similar between BD and NIPE (p= 0.6). Among patients with BD, PA wall thickness was significantly lower in patients with only mucocutaneous involvement compared to patients with major organ involvement (0.37 mm vs 0.47 mm, p&lt; 001), it was also similar between patients with only mucocutaneous involvement and healthy controls (0.37 mm vs 0.36 mm, p= 0.3). PA wall thickness was comparable between patients with vascular and non-vascular major organ involvement (0.46 mm vs 0.47 mm, p= 0.3). Patients with vascular and non-vascular major organ involvement had significantly higher PA wall measurements compared with NIPE patients (p= 0.04, p= 0.02, respectively). Conclusion We found that PA wall thickness was significantly higher in BD with major organ involvement compared to BD patients with only mucocutaneous involvement regardless of major organ involvement type. These results suggest that increased PA wall thickness in BD may be the predictor of the major organ involvement during follow-up. References [1]Ambrose N, Pierce IT, Gatehouse PD, Haskard DO, Firmin DN. Magnetic resonance imaging of vein wall thickness in patients with Behçet’s syndrome. Clin Exp Rheumatol. 2014;32(4 Suppl 84): S99-102. [2]Boulon C, Skopinski S, Constans J. Vein inflammation and ultrasound in Behçet’s syndrome. Rheumatology (Oxford). 2016;55(10):1750. [3]Suresh K, Shimoda LA. Lung Circulation. Compr Physiol. 2016;6(2):897-943. Published 2016 Mar 15. doi:10.1002/cphy.c140049 Disclosure of Interests None declared
AB1266 ANGIOTENSIN-CONVERTING ENZYME LEVEL IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS
Authors: N. Shevchenko, T. Holovko, L. Bohmat, V. Nikonova
Journal: Annals of the Rheumatic Diseases (2022)

Background One of the most common comorbid conditions accompanying rheumatoid arthritis is atherosclerosis and arterial hypertension. Previous studies have shown a change in the blood lipid spectrum with an increase in the atherogenic index in children with juvenile idiopathic arthritis. The next link in the development of this pathology is a change in the endothelial function of the vessels. Objectives To study the level of angiotensin-converting enzyme in children with JIA and establish its interdependence with the blood lipid spectrum of sick children. Methods The level of angiotensin-converting enzyme (ACE) was studied in 46 children (28 girls and 18 boys) from 11 to 17 years old by enzyme immunoassay as well as indicators of the lipid spectrum: low density lipoprotein cholesterol (LDL), very low-density lipoprotein cholesterol (VLDL) and atherogenic coefficient. The results obtained were compared with the data of children in the control group, which consisted of 34 people. Data were analyzed depending on patients’ gender, age, and age of JIA onset, its variant, duration, activity, and presence of methotrexate (MTX). Results The results of the study are presented in the Table 1. Table 1. Lipid spectrum indicators Children’s groups M+m Me Min Max р LDL JIA, n=46 2,33±0,09 2,18 0,97 4,31 0,001 Control, n=34 2,5±0,09 2,55 1,39 4,13 VLDL JIA, n=46 0,36±0,09 0,35 0,13 1,1 0,001 Control, n=34 0,14±0,01 0,13 0,06 0,27 KA JIA, n=46 2,04±0,09 1,83 0,82 3,5 0,4 Control, n=34 2,03±0,09 2,02 0,83 3,8 ACE JIA, n=46 41,23±3,9 35,59 14,4 101,2 0,2 Control, n=34 40,22±6,37 46,75 17,97 63,78 There were no significant differences in the ACE level in children with JIA in comparison with the control group. Analysis of the data obtained did not reveal significant changes in the obtained ACE parameters depending on the gender and age of patients, JIA activity, and the presence of MTX in complex treatment. At the same time, a direct correlation of ACE values ​​and low-density lipoprotein levels (r=0.5, p&lt;0.05) was obtained, which confirms the relationship between the ACE level and the development of dyslipoproteinemia in children with JIA. Conclusion The obtained results illustrate the stages of development of atherogenic changes in children with JIA. Data were obtained that against the background of an increase in the level of VLDL and a decrease in LDL, the level of ACE remains preserved, which reflects the absence of changes in the endothelium. Research into these changes is ongoing. Disclosure of Interests None declared
AB0222 THE ALBUMIN TO GLOBULIN RATIO AS A NOVEL INFLAMMATORY MARKER OF RHEUMATOID ARTHRITIS
Authors: M. Liu, Z. Huang, Y. Huang, Z. Huang, Q. Huang, T. Li
Journal: Annals of the Rheumatic Diseases (2022)

Background The albumin to globulin ratio (AGR) has recently been identified as a new prognostic factor in patients with several types of cancer. However, the correlation of AGR and the disease activity in patients with rheumatoid arthritis (RA) have not been reported. Objectives This study aimed to explore the clinical value of AGR in RA and its association with disease activity. Methods This retrospective study collected 137 RA patients and 82 age- and sex-matched healthy controls. Neutrophil, lymphocyte, monocyte, platelet, albumin, globulin, AGR, neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), platelet to lymphocyte ratio (PLR), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), Disease Activity Score of 28 joints-ESR (DAS28-ESR) and other laboratory parameters were recorded. Receiver operating characteristic (ROC) curves were used to determine the area under curve (AUC) value. The relations between inflammatory indexes and DAS28-ESR were checked. Results The AGR was lower in RA patients than in healthy subjects ( P &lt; 0.05) and decreased significantly along with the disease activity of RA patients ( P &lt; 0.05). According to the ROC curve which was conducted to discriminate RA patients from healthy individuals, the AGR (0.881, 95% CI: 0.837 - 0.924) showed the highest AUC than albumin (0.868, 95% CI: 0.823 - 0.914), globulin (0.789, 95% CI: 0.729 - 0.849), NLR (0.801, 95% CI: 0.742 - 0.859), MLR (0.762, 95% CI: 0.699 - 0.826) and PLR (0.803, 95% CI: 0.745 - 0.860). Spearman analyses showed that AGR was reversely associated with DAS28-ESR (r = -0.545, P &lt; 0.001). Besides, the relevance between AGR and DAS28-ESR was higher than albumin (r = -0.381, P &lt; 0.001), globulin (r = 0.492, P &lt; 0.001), NLR (r = 0.444, P &lt; 0.001), MLR (r = 0.189, P = 0.027) and PLR (r = 0.423, P &lt; 0.001). Conclusion The results demonstrated that the AGR was decreased in RA patients and may be a potential marker for monitoring the disease activity of RA patients. References [1]Zhang C C, Zhang C W, Xing H, et al. Preoperative Inversed Albumin-to-Globulin Ratio Predicts Worse Oncologic Prognosis Following Curative Hepatectomy for Hepatocellular Carcinoma[J]. Cancer Manag Res, 2020,12:9929-9939. Disclosure of Interests None declared
AB1329 INTERAPOPHYSEAL JOINTS INJECTION UNDER ULTRASOUND GUIDANCE AN ALTERNATIVE TO FLUOROSCOPY GUIDANCE
Authors: E. Touboul, S. Salomon-Goeb, V. Deprez, M. Boistelle, V. Goeb
Journal: Annals of the Rheumatic Diseases (2022)

Background Ultrasound-guided injections are an alternative to evaluate, it eliminates the risk of ionizing radiation for both the patient and the practitioner as fluoroscopic procedures require a radiology technician, increase the overall support time and cost, decrease accessibility. Objectives The main objective of the study was to compare the short-term efficacy of posterior inter-apophyseal joint infiltrations under ultrasound versus scopic guidance. Methods Observational, retrospective, single-centre study. Patients benefited from posterior zygapophysial joints injection(s) under fluoroscopy or ultrasound and a follow-up consultation at one month. Results Data from 54 patients was collected. The evolution of VAS at 1 month was on average - 31.4cm (p &lt;0.001) in the ultrasound group and - 31.3cm (p &lt;0.001) in the fluoroscopy group with no statistically significant difference between the two groups (p =0.835). There were no injection-related complications in either group during the follow-up. The decrease in the consumption of NSAIDs was no statistically significant difference between both groups (p = 1.00). Statistically significant differences in procedure time were observed between groups with a longer time recorded for the ultrasound group (p = 0.007). Conclusion A corticosteroid injection of the posterior zygapophysial joints under ultrasound allows for a significant reduction in pain after one month with no difference found between the two techniques. Injection under ultrasound are a reliable, accessible and safe alternative. Disclosure of Interests None declared
Mediterranean Diet vs Low-fat Diet for Patients With Heart Disease
Authors: Anita Slomski
Journal: JAMA (2022)

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POS1455 EFFICIENCY OF PASSIVE MECHANOTHERAPY IN COMPLEX REHABILITATION OF PATIENTS WITH OSTEOARTHRITIS
Authors: E. Orlova, I. Pogonchenkova
Journal: Annals of the Rheumatic Diseases (2022)

Background Different types of physical exercises relieve pain, improve functional status and quality of life in patients with osteoarthritis (ОА) in addition to drug treatment [1–4]. Objectives To evaluate the efficiency of robotic mechanotherapy (continuous passive motion) in the complex rehabilitation of patients with OA. Methods 58 patients with ОА of the knee, hip, wrist and hand joints (76% females, age of 49 to 65 years, disease duration of 3 to 11 years) were included in the study and randomized into 2 groups. 28 study group patients underwent robotic passive mechanotherapy (continuous passive motion) for the knee and hip joints using «ARTROMOT K1» machine (Ormed gmbh, Germany), for the wrist and hand joints using «Kinetec Maestra hand and wrist CPM» machine (Kinetec, UK) (10 sessions for 20–25 min) in addition to the standard rehabilitation program (2 weeks). 30 control group patients received only the standard rehabilitation program, which included 10 group sessions of physical exercises for the joints for 45 min under the supervision of a trainer, 10 procedures of electrostatic massage for muscles and periarticular tissues, 10 sessions of occupational therapy for 45 min (joint protection strategies, use of assistive devices and adaptive equipment). All patients received NSAIDs and SYSADOA at standard dosages. Intra-articular corticosteroids were not used. Tender joint count, joint pain on 100-mm VAS, Lequesne and WOMAC indexes, the amplitude of flexion in the knee joint measured by goniometer, the march test (passage time of 20 meters per sec), hand grip strength measured by a dynamometer were evaluated at baseline and at 2 weeks. Results After 2 weeks in the study group pain on VAS decreased by 40,9% (p&lt;0,05), tender joint count – by 38,7% (p&lt;0,05), Lequesne index – by 1,53 times (р&lt;0,01), WOMAC – by 1,21 times (р&lt;0,01). In the study group the amplitude of flexion in the knee joint increased by 34,2% (p&lt;0,05), the march test decreased by 3,5±1,2 sec (28,8%) (p&lt;0.05), the grip strength of the more affected hand enhanced by 22,3% (p&lt;0,05), of the less affected hand – by 18,5% (р&lt;0,05). In the study group there were statistically significant differences from the control group in all parameters (р&lt;0,05), excluding the grip strength of the less affected hand (р&gt;0,05). Conclusion 2-week complex rehabilitation program, including robotic mechanotherapy (continuous passive motion), relieves pain, improves functional ability, motor activity (march test, range of motion in the knee joint, hand grip strength) in patients with OA. References [1]Goh SL, et al. Sports Med 2019;49(5):743–61. [2]Rice D, et al. J Clin Med 2019;8(11):1769. [3]Shi-Qi Wang, et al. Geriatr Orthop Surg Rehabil 2020;11:2151459320973196. [4]Chu-Yang Zeng, et al. Front Physiol 2021;12:94062. Disclosure of Interests None declared
POS0746 MEASUREMENT OF ANTI-SUPRABASIN ANTIBODIES, MULTIPLE CYTOKINES AND CHEMOKINES AS POTENTIAL PREDICTIVE BIOMARKERS FOR NEUROPSYCHIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: T. Hoang, K. Ichinose, S. Morimoto, K. Furukawa, L. Le, A. Kawakami
Journal: Annals of the Rheumatic Diseases (2022)

Background The pathogenesis of neuropsychiatric systemic lupus erythematosus (NPSLE) is multifactorial and involves diverse cytokines, autoantibodies and immune complexes inducing blood-brain barrier (BBB) dysfunction, neuroendocrine-immune imbalance, vascular occlusion, tissue, and neuronal damage. Several pro-inflammatory cytokines have been implicated in the pathogenesis of NPSLE [1]. Previously we have shown that the titer of anti-suprabasin (SBSN) antibodies in cerebrospinal fluid (CSF) of NPSLE patients was significantly higher than in SLE, MS and NPH groups [2]. However, distinguishing NPSLE from other neuropsychiatric conditions with different etiologies is challenging. Objectives This study determined the most critical serum biomarkers for the development of NPSLE as they may have clinical utility prior to the onset of neuropsychiatric symptoms. Methods We retrospectively analyzed 35 NPSLE patients, 34 SLE patients, 20 viral meningitis (VM) patients, and 16 relapsing-remitting multiple sclerosis (MS) patients. We measured anti-SBSN antibodies concentrations in serum by using Luciferase immunoprecipitation system (LIPS) assay. The serum concentrations of cytokines/chemokines were measured by using multiplex bead-based assay. All the clinical information and laboratory tests were collected at the time of admission. Results The Bayesian posterior mean and 95% HPDI of the cut-off of AI and its PPV and 1-NPV values were 5.26 (3.68;7.17), 0.87, (0.72; 1.0) and 0.44, (0.36; 0.5), respectively (Figure 1). Figure 1. Summary of the posterior distribution of the cutoff of AI and its predictive value (1-NPV and PPV). The 95% HPDI is shown as the thick black horizontal line with the boundaries written above the line Among analyzed biomarkers, VEGF had the highest sparsity-oriented important learning (SOIL) importance, followed by AI, sCD40L, IL-10, GRO, MDC, IL-8, IL-9, TNFα, MIP-1α (Figure 2). Figure 2. Top 10 biomarkers having highest SOIL importance in prediction of NPSLE. Abbreviations • AI: anti-SBSN antibody index • PPV: positive predictive • NPV: negative predictive value • SOIL: sparsity-oriented important learning • IL: interleukin •MIP: macrophage inflammatory protein • sCD40L: soluble CD40 ligand • MDC: macrophage-derived chemokine • VEGF: vascular endothelial growth factor • MDC: macrophage-derived chemokine • TNF: Tumor necrosis factor Conclusion Our data demonstrated the ranking of serum biomarkers for the prediction of NPSLE. The most essential biomarkers are VEGF, anti-SBSN antibodies, sCD40L, IL-10, GRO, MDC, IL-8, IL-9, TNFα, MIP-1α. References [1]Govoni M, Hanly JG: Rheumatology (Oxford), 2020: 59(Suppl5):v52-v62. [2]Ichinose K, et al: Clinical immunology, 2018; 193:123-130. Disclosure of Interests None declared
AB1012 MANAGEMENT OF BREAST CANCER TREATMENT INDUCED BONE LOSS- RE-AUDIT
Authors: G. Ansari, A. Nandagudi, S. Pattapola
Journal: Annals of the Rheumatic Diseases (2022)

Background Breast cancer treatment therapies (aromatase inhibitors (AI)) are associated with early menopause and adverse effect on bone density. Identifying high-risk patients and managing them appropriately will help reduce their fracture risk. Objectives We wanted to ascertain whether our management of breast cancer patients on aromatase inhibitors (AI) referred to osteoporosis clinic were as per guidelines. A consensus position statement from a UK expert group regarding breast cancer treatment induced bone loss, published with the support of the National Osteoporosis Society, the National Cancer Research Institute, Breast Cancer Study Group and the International Foundation. The guideline recommend lifestyle advice for low risk patients; calcium plus vitamin D supplementation and lifestyle advice for medium risk; bisphosphonate, calcium plus vitamin D supplementation and lifestyle advice for high risk. Methods This is a re-audit cycle conducted for all patients referred to the osteoporosis clinic who were treated with aromatase inhibitors for breast cancer between 2016-2020. Patients were divided into two algorithms: Algorithm 1: women who had experienced premature menopause associated with ovarian suppression with or without AI. Algorithm 2: Postmenopausal women receiving treatment with an AI. T-scores were used to stratify patients in algorithm 1 into high risk (HR- T score &lt;-2), medium risk (MR-T score -1 to -2) and low risk (LR- T score &gt;-1). Algorithm 2 into high risk (HR-T score &lt;-1) medium risk (MR -T score &gt;-1). Results: Table 1. Showing the results of Audit 1 and Re-audit Audit 1 Re-audit Total Patients 54 72 Data collected 2014-2016 2016-2020 Gender Female 100 (%) Female 100 (%) Age in years 45-96 38-92 Median age 77 68 No of Osteoporotic patients 31 41 No of Osteopenic patients 23 31 Algorithm 1: Total patients=23 • 18 HR• 5MR• LR nil Total patients = 20 • 19HR • 1 MR Algorithm 2: Total patients =31 • 31 HR • MR-nil • LR nil Total patients =52 • 45HR • 5MR • 2LR Drug therapy 45 63 Bisphosphonates 21 49 Denosumab 23 14 Teriparatide 1 0 Declined treatment 0 1 Lifestyle/Vit D &amp; Cal 9 6 Lifestyle advice only 0 2 Conclusion Re-audit showed all patients were on AI and treated appropriately. As compare to audit 1, all high risk group patients were treated with drug therapy and bisphosphonate was the first line therapy as per guidelines. It was recommended that patients with risk of osteoporosis should be referred and treated according to their risk stratification. It is a collective responsibility of Breast surgeons, Geriatrician, Frailty team, Oncologist, Rheumatology and General Practitioners).All patients should have repeat bone density scan in 2 years’ time after initial bisphosphonate therapy. The next audit cycle will be conducted in five years’ time. Disclosure of Interests None declared