tbuckley/cabot-search huggingface dataset:
Lipid and Body Fluid Patterns in North American Negro and White Prisoners
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reports to the Membership
Journal: American Journal of Psychiatry (2016)

The following are edited/abbreviated versions of the annual reports of the APA Secretary, Treasurer, CEO and Medical Director, Speaker, and Speaker-Elect and the chairpersons of the APA Committee on Bylaws, Membership Committee, Committee of Tellers, and Elections Committee. The full reports were presented at the APA Annual Business Meeting in Atlanta, May 15th, 2016.
Public Service Pensions Increased
Journal: BMJ (1974)

Suggesting that the main criterion for setting up a deputizing service was com- meroially viability, Dr. M. A. WILSON argued that such services could not be available in small towns and rural areas.Dr. J. G. BALL had no objection to deputizing services provided they were used reasonarbly, but in his view using a service seven nights a week was wrong because it betrayed a change of attitude by the doctor.Dr. J. K. M. DEAS suggested that Dr
Contents
Authors: R Moreau, R Bataller, T Berg, J Zucman-Rossi, R Jalan, R Poupon, A De Niet, F Stelma, L Jansen, M Sinnige, E Remmerswaal, R Takkenberg, N Kootstra, H Reesink, R Van Lier, E Van Leeuwen, N Yamamoto, Y Sato, T Munakata, M Kakuni, C Tateno, T Sanada, Y Hirata, S Murakami, Y Tanaka, K Chayama, H Hatakeyama, M Hyodo, H Harashima, M Kohara, F Lempp, P Mutz, C Lipps, D Wirth, R Bartenschlager, S Urban, N Helsen, Y Debing, J Paeshuyse, K Dallmeier, R Boon, M Coll, P Sancho-Bru, C Claes, J Neyts, C Verfaillie, R Mookerjee, M Pavesi, K Thomsen, G Mehta, J Macnaughtan, F Bendtsen, M Coenraad, J Sperl, P Gines, V Arroyo, T Yang, J.-H Lu, W Lau, T.-Y Zhang, H Zhang, Y.-N Shen, K Alshebeeb, M.-C Wu, M Schwartz, F Shen, J Shindoh, M Makuuchi, Y Matsuyama, Y Mise, J Arita, Y Sakamoto, K Hasegawa, N Kokudo
Journal: Journal of Hepatology (2016)
Correction
Journal: BMJ (1947)

say that if a doctor had a thousand panel patients at least half of them would undoubtedly turn up at the surgery every day.Comment on this is unnecessary.(2) Sir Ernest Graham-Little states that there are probably 50,000 doctors in active practice working at the present time, and that three times this number will be required under State medicine for eight-hour shifts.Does he not realize that in a town which normally keeps, say, twelve doctors busily at work during the day, the night work could easily be done by one
Chromosomal abnormality rates at amniocentesis and in live-born infants
Authors: E. B. Hook
Journal: JAMA (1983)

Regression-smoothed maternal age-specific rates of six different categories of cytogenetic abnormalities in recent large-scale prenatal cytogenetic studies were multiplied by independently derived fetal selection coefficients—factors that adjust for the excess likelihood of spontaneous loss of cytogenetically abnormal fetuses—to obtain estimated maternal age-specific rates of these categories of cytogenetic abnormalities in live-born infants. The derived rates apply to women whose only risk factor is advanced maternal age. The categories analyzed were 47,+21 (Down's syndrome), 47,+18 (Edwards' syndrome), 47,+13 (Patau's syndrome), 47,XXY (Klinefelter's syndrome), 47,XXX, and the group of other clinically significant abnormalities considered collectively. The rate of all clinically significant abnormalities considered together derived in this study was about five per 1,000 at age 35 years, 15 per 1,000 at age 40 years, and 50 per 1,000 at age 45 years. (<i>JAMA</i>1983;249:2034-2038)
Pulmonary embolism
Authors: J. E. Dalen
Journal: JAMA (1969)

Few diseases are as common, as potentially lethal, and yet as frequently unrecognized as pulmonary embolism. When pulmonary emboli have been carefully sought at postmortem examination, the incidence has been found to be in excess of 25%.<sup>1-3</sup>At the Peter Bent Brigham Hospital, pulmonary embolism is one of the three most common causes of death.<sup>1</sup>Yet, the correct premortem diagnosis is made in only about 50% of the cases. The number of deaths due to pulmonary embolism may be decreased by early recognition and prompt treatment, thus minimizing the risk of additional episodes of potentially lethal embolism. <h3>Recognition of Pulmonary Embolism</h3> The well-known difficulty in recognizing pulmonary embolism is, in part, due to the fact that it can present as four different clinical syndromes: <h3>1. Pulmonary Infarction.—</h3> Although pulmonary infarction is the most familiar manifestation of pulmonary embolism, it is one of the least frequent complications of embolism.
Rationing and the Americans With Disabilities Act
Authors: L. M. Kopelman
Journal: JAMA (1994)

<h3>In Reply.</h3> —Although Dr Kopelman's letter suggests that important differences exist between her views and mine, in fact we are in substantial agreement. The concerns that she mentions reflect a misreading of my article. As Kopelman observes and as I argue, constraints of cost and efficiency should not vitiate the right of persons with disabilities to equality of treatment, and as she suggests, criteria for allocating health care must be articulated openly and subjected to public scrutiny. My article proposes such criteria and indicates how the criteria should be applied. Specifically, I argue that rationing decisions must be justified by legitimate nondiscriminatory factors, and I put forth the five criteria that Kopelman quotes. I do not pretend that these criteria provide a complete guide to rationing, however. The criteria are difficult to quantify and are not as objective and ethically neutral as they appear. For example, treatments for persons with
Abstract A2-66: Integrative analysis of gene expression and metabolism in isocitrate dehydrogenase 1 mutant acute myeloid leukemia and myeloid knock in mouse model
Authors: Alan Tseng, Wanda Li, Kim-Chung Lee, Karrie Yung, Ching-Wan Lam, Tak Mak
Journal: Cancer Research (2015)

Abstract Isocitrate dehydrogenase 1 (IDH1) mutations are common drivers of acute myeloid leukemia (AML). While mutant IDH1 is known to disrupt DNA methylation, gene expression, and metabolism in cell lines, it is not known how mutant IDH1 alters global metabolism in vivo. The purpose of this study is to find differential enzymes and metabolites in IDH1 wild type versus mutant AML and knock in mice by integrating differential genes and metabolites in a metabolic network. Differential genes were found by comparing gene expression and DNA methylation in IDH1 mutant (n = 12) and wild type (n = 89) cytogenetically normal AML patients from The Cancer Genome Atlas. Differential metabolites were found by untargeted liquid chromatography-mass spectrometry of urine, plasma, and bone marrow hematopoietic stem and progenitor cells from unpaired 1-2 year old mixed-sex IDH1 myeloid knock in (n = 13) and control mice (n = 14). Integrative analysis was performed using the MetScape 2 Cytoscape plugin. 71 differential genes and 52 differential metabolites were mapped to the global metabolic network. The set of differential genes and metabolites formed 10 connected subnetworks containing reactions in sphingolipid, phospholipid, and bile acid metabolism. Two enzymes in the subnetworks were differentially expressed in an independent IDH1 mutant versus wild type AML dataset: acyl-CoA thioesterase 4 (ACOT4) and galactosylceramidase (GALC) (P &amp;lt; 0.05, false discovery rate ≤ 0.3). ACOT4 and GALC were significantly upregulated (P &amp;lt; 0.02) in acute promyelocytic leukemia cells treated with all-trans retinoic acid. In conclusion, we have found novel differential genes and metabolites in IDH1 mutant systems which may be relevant to leukemia differentiation treatment. Integrative analysis of gene expression and metabolite levels could be useful for finding dysregulated metabolic subnetworks in cancer. Citation Format: Alan Tseng, Wanda Li, Kim-Chung Lee, Karrie Yung, Ching-Wan Lam, Tak Mak. Integrative analysis of gene expression and metabolism in isocitrate dehydrogenase 1 mutant acute myeloid leukemia and myeloid knock in mouse model. [abstract]. In: Proceedings of the AACR Special Conference on Translation of the Cancer Genome; Feb 7-9, 2015; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(22 Suppl 1):Abstract nr A2-66.
Patients' lack of literacy may contribute to billions of dollars in higher hospital costs
Authors: C. Marwick
Journal: JAMA (1997)

PHYSICIANS, nurses, hospitals, pharmacists and other providers of medical care are not the only controllers of health care costs. The US educational system plays a substantial role and, according to a recent estimate, it is in such a parlous state that its results—or lack of results—contribute to an estimated $15 billion a year in excess hospital costs alone. Some 40 million to 44 million Americans are functionally illiterate, the National Adult Literacy Survey has estimated. They are unable to read and comprehend adequately to function in society. Apart from other social disadvantages, this means they cannot understand a physician's prescription or health care instructions, and, perhaps even more important, they are unable to navigate through the complex health care system. The result is that not only are they in poorer health, with higher health care costs and more frequent hospitalizations than their literate fellow Americans, but they are unable
Technique for Preventing Pulmonary Embolism Reported to AMA Convention
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transplant 'hot line' aids organ search
Authors: P. Gunby
Journal: JAMA (1983)

For about 4 1/2 months now, organ procurement has been facilitated by a recorded telephone message. The 10- to 12-minute message tells which centers are seeking what kind of organs on that day, the blood type of would-be recipients, and the size of the donor needed (if the patient is an infant or child). It also indicates what distance the center's personnel are willing to travel, often in a corporate jet loaned for this purpose, to harvest the organ. The 110 organ procurement centers that are involved originally concentrated on recovering kidneys for the 6,000 or so US patients who are awaiting renal transplants at any given time. However, since late September, the network has been extended through the North American Transplant Coordinators Organization to connect hospitals in which other organs—livers, hearts, and lungs—have become available with centers where appropriate patients are awaiting transplantation. So far, says Donald W. Denny,
PWE-216 Confocal endomicroscopy demonstrates increased intestinal permeability and gut dysfunction in patients with acute and chronic pancreatitis
Authors: S Bharucha, J Geraghty, C Duckworth, J Armstrong, P Szatmary, S Winn, S Sarkar, I Welters, A Watson, D Pritchard, R Sutton
Journal: Gut (2015)

<h3>Introduction</h3> Increased intestinal permeability and endotoxaemia occur in acute pancreatitis (AP) but have yet to be confirmed in chronic pancreatitis (CP). Confocal endomicroscopy (CEM) is a novel technology that has identified epithelial gaps and leakage of intravenously administered fluorescein from small intestinal mucosa in inflammatory bowel diseases. We aimed to determine intestinal permeability changes in AP and CP using CEM, assessing associations with endotoxaemia, circulating cytokines and alterations in duodenal flora. <h3>Method</h3> 182 patients were recruited: 35 mild AP; 11 moderate AP; 8 severe AP (Determinant Based Classification); 47 CP (27 surgically managed, 20 conservatively managed); 33 chronic liver disease and 48 non-ulcer dyspepsia (from whom 14 healthy <i>H. pylori</i>negative controls were identified). Blood was sampled and duodenal fluid aspirated for culture. CEM was performed in consenting patients and fluorescein leakage scored by two independent blinded investigators. Plasma endotoxin antibodies, serum cytokine concentrations and lactulose:mannitol ratios were measured; D-amino oxidase concentrations were assayed in AP patients undergoing CEM. <h3>Results</h3> Fluorescein leakage from epithelial villi at CEM and lactulose:mannitol ratios were significantly higher in AP patients (p = 0.0346 and p = 0.046 respectively) and surgically managed CP (p = 0.032, p = 0.030) compared to healthy controls. Patients with AP more frequently showed positive duodenal bacterial cultures than controls (p = 0.004); positive duodenal cultures were associated with fluorescein leakage (p = 0.035). Plasma IgM and IgG concentrations were decreased in AP compared to controls, most markedly in severe AP, and multiple cytokines showed significantly increased concentrations in severe AP. D-amino oxidase enzyme concentrations were significantly increased in those AP patients who showed fluorescein leakage at CEM (p = 0.035). <h3>Conclusion</h3> CEM identified increased intestinal permeability in AP and surgically managed CP, associated with endotoxaemia, increased serum inflammatory cytokines and D-amino oxidase. These changes were most marked in severe AP. The association of fluorescein leakage with duodenal bacterial proliferation in AP indicates major gut dysfunction that may account for bacterial translocation via epithelial gaps, contributing to AP severity. <h3>Disclosure of interest</h3> None Declared.
ABSTRACTS
Authors: Joseph Ross, Helen Belding, Winston-Salem Maier, Robert Chodos, Netou Ek, Roger Crafts, Charles Rath, Washington Dasgupta, Jean Souhier, Solomon Estren, York Ram, M Su#{225}rez, Juan Puerto, Rico Oliver, P Jones, Timothy Talbot, Philip Wagley, H ('olliei-, B Pirrie, J Houston, H Thompson
Journal: Blood (1952)
Regulation of Hemoglobin Synthesis during the Development of the Red Cell
Authors: Arthur W. Nienhuis, Edward J. Benz
Journal: New England Journal of Medicine (1977)

Mouse Erythroleukemia CellsOur emphasis on the biochemical aspects of globin-gene expression and mRNA production parallels the focus of much experimental work, but should not obscure the fact that erythroid maturation represents a co-ordinated expression of many structural genes. The mechanisms of co-ordinated gene regulation in micro-organisms have been experimentally accessible because mutant strains are available for analysis under defined growth conditions. The mouse erythroleukemia cell is being intensely studied in the hope that a similar approach can be developed for the molecular events underlying erythroid maturation.General PropertiesMouse erythroleukemia cells resemble proerythroblasts and basophilic . . .
PERINEPHRITIC ABSCESS
Authors: VERNE C. HUNT
Journal: JAMA (1924)

Infection and inflammatory reaction in the perirenal tissues is a common finding at operation and at necropsy. However, true abscess formation in this area is uncommon, and its symptoms are usually so vague and difficult to interpret that the possibility of it must always be borne in mind in order to insure a successful termination. While the classification of perinephritic abscesses as primary or secondary has been universally accepted, a review of the cases reported in the literature, and of cases observed in the Mayo Clinic on which such classification is based, fails to disclose a single instance in which primary infection of the perirenal tissues resulted in abscess formation, independent of primary renal or extrarenal infection. The classification of perinephritic abscesses on an etiologic basis furnishes a most adequate method for their consideration. Such abscesses are either of renal or extrarenal origin. Those of renal origin are caused, in
Doctor Moon
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary
Journal: BMJ (2004)

69-81 months, P = 0.05; doctor diagnosed asthma, 91 months, P = 0.005), it should be noted that, because of small numbers in some groups, the confidence intervals were wide and the results did not support the hypothesis.When we adjusted for potential confounding factors we detected no significant associations (P = 0.1-0.8).took part and the midwives for their cooperation and help in recruitment.The whole ALSPAC study team comprises interviewers, computer technicians, laboratory technicians, clerical workers, research scientists, volunteers, and managers who continue to make the study possible.The ALSPAC study is part of the European Longitudinal Study of Parents and Children initiated by the World Health Organization.Contributors:
Editorial Board
Authors: Cezmi Akdis, Zuhair Ballas, Iowa City, Iowa Deputy Editor, Stanley Szefler, Colo Associate, Andrea Apter, Leonard Philadelphia, St Bacharier, Claus Louis, Joshua Boyce, Robert Bush, Javier Chinen, Raif Geha, Kyoto Japan, Carole Ober, David Peden, Chapel Hill, Harald Renz, Marburg Germany, Marc Rothenberg, Cincinnati Ohio, Hirohisa Saito, Tokyo Japan, Stephan Weidinger, Robert Wood, In-Chief Donald, Y Leung, Amos Etzioni, James Gern, Robert Hamilton, Paul Bryce, Mariana Castells, Mitchell Grayson, Bruce Mazer, Ariel Munitz, Kari Nadeau, Bruce Bender, Pascal Chanez, Morton Cowan, San Francisco, Elizabeth Matsui
Journal: Journal of Allergy and Clinical Immunology (2017)
PROGRESS IN CHILD LABOR LAWS.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Testing for lung cancer in people at high risk
Journal: CA A Cancer Journal for Clinicians (2013)

Lung Cancer FactsIn the United States, lung cancer is the leading cause of death from cancer.It occurs more commonly after age 60 years.Some people are at a higher risk of developing lung cancer because of their smoking history along with their older age.Smokers can reduce their risk of developing and dying from lung cancer by quitting because the risk of lung cancer steadily increases as long as smoking continues.If lung cancer is diagnosed at an earlier stage, while it is small and before it has spread, people have a better chance of living longer.
Transtracheal Ventilation
Authors: George E. Battit
Journal: JAMA (1976)

<h3>To the Editor.—</h3> Our article entitled "Transtracheal Ventilation" (234:1152, 1975) is intended to serve two objectives. These objectives are (1) to publicize further this valuable emergency technique and (2) to document the flow characteristics of catheters of various sizes. The clinical value of this technique was supported with a brief case report. Both stated objectives have been met. Dr Craig (235:2082, 1976) implies a grave error in our not having cited the work of Jacoby et al published in 1956. Our apologies to Dr Craig and to Dr Jacoby and associates. On the other hand, our intention was simply to achieve the two objectives mentioned earlier. Incidentally, Dr Craig did not notice that we mentioned subcutaneous emphysema as a possible complication (p 1153, col 2, second last line).