tbuckley/cabot-search huggingface dataset:
First Aid X-Ray Atlas of Fractures and Dislocations, Including Illustrated Description of the Skeleton.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase 1/2a study of double immune suppression blockade by combining a CSF1R inhibitor (Pexidartinib/PLX3397) with an anti PD-1 antibody (Pembrolizumab) to treat advanced, solid tumors.
Authors: Amita Patnaik, Peter D. Eisenberg, Jasgit C. Sachdev, Amy M. Weise, Archie N. Tse, Marguerite Hutchinson, Ireene Aromin, Brian West, Sandra Tong, Antoni Ribas, Siwen Hu-Lieskovan
Journal: Journal of Clinical Oncology (2016)

TPS11618 Background: Tumor-associated macrophages (TAMs) support tumor growth and cause tumor resistance to chemotherapy and radiation therapy, and myeloid-derived suppressor cells (MDSCs) suppress anti-tumor immunity and cause resistance to PD-1 inhibition. TAMs and MDSCs are both regulated in part by colony stimulating factor 1 (CSF1), which signals via its receptor (CSF1R). Pexidartinib is an orally administered, small molecule inhibitor of the CSF1R. The normal function of PD-1, expressed on the cell surface of activated T-cells, is to suppress excessive immune responses such as autoimmune reactions. Tumors can utilize PD-1 signaling to downregulate immune-mediated elimination. Pembrolizumab is a potent and highly selective humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2. We present the study design for an ongoing Phase 1/2a clinical trial assessing the safety, efficacy, pharmacokinetics, and pharmacodynamics of the pexidartinib/pembrolizumab combination in advanced, solid tumors (NCT02452424). Methods: In Part 1 of this open-label, uncontrolled study, patients with advanced solid tumors will be treated with pembrolizumab (200 mg intravenously every 3 weeks) and escalating daily oral doses of pexidartinib to determine the safety and tolerability as well as establish a recommended phase 2 dose (RP2D) for the combination regimen. In Part 2, the combination RP2D will be studied in an expanded panel of solid tumor cohorts in up to 508 patients to further determine safety and preliminary efficacy. Overall response rate (ORR) and progression free survival (PFS) will be evaluated using RECISTv1.1 criteria. Exploratory objectives include identifying biomarkers of clinical activity and drug mechanisms of action. A truncated sequential probability ratio test will be employed in each tumor cohort to allow early decision-making for futility or success. The results will support further development of the pexidartinib/pembrolizumab combination in the solid tumor subtypes that respond to treatment in this study. Clinical trial information: NCT02452424.
Metabolic Studies on Mononuclear Cells from Rabbits of Varying Genetic Resistance to Tuberculosis: IV. Studies on Cortisone-Treated Animals
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TRYPANOSOMES.
Authors: FREDERICK G. NOVY
Journal: JAMA (1907)

<h3>GAMBIAN HORSE DISEASE.</h3> This disease was first recognized by Dutton and Todd, in 1902, among the horses of Senegambia. Of 36 examined, 10 were found to have the trypanosome in their blood. As far as known no other domestic animal is subject to the disease, although most mammals, including sheep, goats and cattle, can be infected. The natural disease is very chronic in character and differs from nagana by the absence of edemas. In the latter respect it agrees with caderas, but, as will be seen, the trypanosomes of these two diseases are easily differentiated. The duration of the disease is not known, though it probably lasts from a few months to more than a year. In an experimental infection of a horse, Laveran and Mesnil noted the formation of an edematous patch, but otherwise the animal did not appear to be ill. There was an occasional rise in temperature
Barium impaction as a complication of gastrointestinal scleroderma
Authors: M. A. Thompson
Journal: JAMA (1976)

Two patients with scleroderma of the bowel experienced life-threatening barium impaction after upper intestinal x-ray studies. Although the frequency of this complication is unknown, the difficulty of managing it when it occurs makes prevention imperative. X-ray studies should be performed only after careful consideration of the risks and benefits. When x-ray studies are performed, the patient should be vigorously purged soon thereafter, and a follow-up roentgenogram should be obtained to confirm adequate removal of barium. (<i>JAMA</i>235:1715-1717, 1976)
AIDS
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lecture on Moral Insanity
Authors: J. Kitching
Journal: BMJ (1857)

BalTIrs MBDIOAL JOulrL.to the hypertrophy of the heart, which he thought due to the impeded circulation in the capillaries, the consequence of the blood disease, and to the absence of dropsy, which he ascribed to the quantity of water, which he had been passing, a result of the denudation of epithelium from so many of the renal tubes, by which only a simple basement membrane is left, through which the fluid easily transudes.CASE v.A gouty old man, aged 71 years, was admitted with dropsy of recent origin.The urine deposited a considerable sediment, and on examination was found highly albuminous, *and contained a large number of small waxy casts entangling pus-globules.After he had been in the house for a few weeks, •a number of cells containing oil appeared in the urine adhering to the casts.This circumstance, joined to his age and un.healthy constitution, caused an unfavourable prognosis to be entertained; as it was feared, from the amount of the oil con- tained in the urine, that the kidneys were undergoing fatty de- generation.IHowever, under the use of dry cupping, milk diet, and purgatives, followed by tincture of sesquichloride of iron, Jie soon began to improve, and has gone on steadily mending.The dropsy is quite gone, and the albumen has nearly disappeared; a small number of casts are still to be seen, but they do not contain any pus or blood.The quantity of urine is greatly increased, and it hardly deposits any sediment.Dr.Johnson remarked in this case the uncertainty of prognosis in our present knowledge of these diseases; the appearance of small pale waxy casts in the urine, containing large cells filled with oil, being generally indicative of extensive and advanced fatty degeneration.CASE vi.The last case is that of an engine driver, who was admitted on April 29th, with dropsy of two months duration.He was extremely pale, and was passing about fifty ounces per diem of urine, containing a good deal of albumen, and a copious sediment of small waxy and granular casts, in which some blood and a few oil.globules could be seen.
GI Highlights from the literature
Authors: G. P. Aithal
Journal: Gut (2011)

<h3>Objective</h3> The study aims to quantify the impact of injury on the financial well-being of older workers. The hypothesis was that injured older workers have substantially reduced income from work following injury, but that New Zealand’s (NZ) universal injury compensation scheme mitigates the difference for total income. <h3>Design, setting and participants</h3> An e-cohort of 617 722 workers aged 45–64 years old was created using de-identified linked administrative data in NZ’s Integrated Data Infrastructure. Person-level data from numerous government agencies were used to compare 21 639 with an injury-related entitlement claim in 2009 with the remaining 596 133. Event date was the date of injury, or for the comparison group, a randomly selected date in 2009. <h3>Primary and secondary outcome measures</h3> Geometric mean ratios (GMRs) were used to compare income from work and total income from all taxable sources between those injured and the comparison group. Adjusted GMRs estimated income differences up to 36 months following the event date. <h3>Results</h3> Differences in total income increased over time. In the third year, those injured received 6.7% less (adjusted GMR 0.933 (95% CI 0.925 to 0.941)) than the comparison group, equivalent to an average loss of $NZ2628. Restricting to income from work, those injured received 29.2% less than the comparison group at 3 years (adjusted GMR 0.708 (95% CI 0.686 to 0.730)). For both men and women, those injured at 45–49 years consistently had the greatest relative income loss compared with those aged 50–54, 55–59 or 60–64 years. <h3>Conclusions</h3> Although the substantial impacts of injury on income were mainly mitigated by public income transfers, relative losses in income in those aged 45–64 years increased in the 3 years following injury. Policies focused on adequate compensation and reducing the time away from employment could reduce these financial impacts in older workers.
THE PROBLEM OF WATER PURIFICATION.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endometrial Cancer in Patients Previously Irradiated for Cervical Cancer
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A CRYSTALLINE PRODUCT OF VENOM.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Corrigendum to: Breast cancer brain metastases show increased levels of genomic aberration-based homologous recombination deficiency scores relative to their corresponding primary tumors
Authors: M. Diossy, L. Reiniger, Z. Sztupinszki, M. Krzystanek, K.M. Timms, C. Neff, C. Solimeno, D. Pruss, A.C. Eklund, E. Tóth, O. Kiss, O. Rusz, G. Cserni, T. Zombori, B. Székely, J. Kulka, J. Tímár, I. Csabai, Z. Szallasi
Journal: Annals of Oncology (2019)

Ann Oncol 2018 (doi:10.1093/annonc/mdy216) Author Janina Kulka was originally missed from the author listing. She has now been added. Breast cancer brain metastases show increased levels of genomic aberration-based homologous recombination deficiency scores relative to their corresponding primary tumorsAnnals of OncologyVol. 29Issue 9PreviewBased on its mechanism of action, PARP inhibitor therapy is expected to benefit mainly tumor cases with homologous recombination deficiency (HRD). Therefore, identification of tumor types with increased HRD is important for the optimal use of this class of therapeutic agents. HRD levels can be estimated using various mutational signatures from next generation sequencing data and we used this approach to determine whether breast cancer brain metastases show altered levels of HRD scores relative to their corresponding primary tumor. Full-Text PDF Open Access
Manual de medicina clinico y de laboratorio
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Citationalization
Authors: Edward Flick
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Now Jacobs' LETTER, "The Importance of Not Being Cited" (<b>217</b>:698, 1971), has achieved the distinction not accorded (or was it? Vide Garfield, "The Road to Scientific Oblivion" [<b>218</b>:866, 1971]) his original article. Cited or uncited, Jacobs' letter at least has been cited by two (count them) communications. The corollary derived is the following: if your article lies quietly interred, write a letter toThe Journaland, to achieve particular attention, include in your bibliography, as did Jacobs, a wild title like<i>Radical Chic and Mau-Mauing the Flak Catchers</i>. Unable to resist the wacky title and having read this book by Tom Wolfe and been whetted further, I found more by the same fine, perceptive essayist—<i>The Electric Kool-Aid Acid Test, and Kandy Kolored Tangerine-Flake Streamlined Baby</i>. Titles like these and subjects biting, witty, and illuminating, yet sadly true as commentary on the "now" scene, combine
Efficacy of Dor procedure on late survival in patients with postinfarction akinetic or dyskinetic scar and predictors of outcome Marisa Di Donato, Michel Sabatier, Anna Toso, Mauro Maioli, Vincent Dor, Gian Franco Gensini, Gerald Buckberg. Dpt of Critical Care Medicine, Florence, Italy, Cardio Thoracic Center, Monaco, Monaco
Journal: Journal of the American College of Cardiology (2001)
Illicit Drug Users Not Idle; Report Says 70% Go to Work
Authors: C. Marwick
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diabetic Retinopathy
Authors: Robert N. Frank
Journal: New England Journal of Medicine (2003)

The risk of blindness from diabetic retinopathy, the most severe ocular complication of diabetes, has greatly diminished, owing to advances in management. This review discusses the spectrum of clinical manifestations of diabetic retinopathy, with particular attention to new aspects of management. Since diabetes is common, diabetic retinopathy remains an important medical problem for affected patients and those caring for them.