tbuckley/cabot-search huggingface dataset:
AB1756-PARE FACTORS ASSOCIATED WITH QUALITY OF LIFE AMONG SCLERODERMA PATIENTS
Authors: Z. Syrine, A. Feki, S. Ben Jemaa, Y. Mabrouk, A. Cyrine, M. Ezzeddine, M. H. Kallel, H. Fourati, R. Akrout, S. Baklouti
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Systemic sclerosis (SSc) is an autoimmune multi-systemic disease with predominant affection of connective tissue resulting in progressive fibrosis of the skin and internal organs. Monitoring measures of functioning and disability is crucial during follow up to identify quality of life impairment. <h3>Objectives</h3> To assess the influence of functional impairment on quality of life in SSc patients. <h3>Methods</h3> A cross- sectional study was carried out on patients followed for systemic sclerosis at a rheumatology department. Included patients completed the Hospital Anxiety Depression scale in its Arabic validated version. The SF-36 short form questionnaire score with its domains (general health, physical function, role physical function, emotional role function, vitality, mental health, social function, body pain, general health) in its arabic Tunisian version was used to assess quality of life. All data was collected after patient consent and was analyzed using the SPSS statistical package. <h3>Results</h3> Forty patients who fulfilled the 2013 ACR/EULAR Classification Criteria for Systemic Sclerosis ACR criteria for SSc were were included. 80% of the patients were female, the median age was 45 years old and median disease duration 1 year. 15%(n=6) had a limited form, and 85% (n=34) had a diffuse form of SSc. Fingertip ulcers were observed in 13 patients (32.5%) and Raynaud's phenomenon was found in 34 patients (85%). Severe organ involvements were detected as interstitial lung disease in 17 (42,5%), pulmonary hypertension in 7 patients (17.5%) and renal involvement in 2 patients (5%). 38 % patients had an HAD scoring rate for "possible clinical anxiety" and for 42% for "possible clinical depression". The SF-36 questionnaire score of each domain was significantly lower in patients with diffuse than in limited form, especially the score in the dimension of Role Physical function and Body Pain, p=0.04 and p=0.02 respectively. Skin involvement and organ damage were also significantly associated with lower SF36-PF (physical function) (p=0.001) and SF36-MH (mental health) p=0.0025 with no significant association with the other score components. <h3>Conclusion</h3> Systemic Sclerosis has a significant effect on patient quality of life. Body image, fatigue, pain, and psychological morbidity should be screened in patients with SSc to promote quality of life. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1673 THE USE OF DIGITAL FOOT SCANNING (PELMATOGRAPHY) FOR IDENTIFICATION OF STANCE ABNORMALITIES IN A YOUNG HEALTHY POPULATION
Authors: I. Katsigianni, E. Skouvaklidou, G. Vounotrypidis, D. Deligeorgakis, D. Zisopoulos, G. Sakellariou, P. Vounotrypidis
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Clinical evaluation of pes anatomy and abnormalities are rarely reported in rheumatology literature. Often deviations from normal are not evaluated, unless subsequent pathology and symptoms are overt. Foot symptoms may occasionally lead to overdiagnosis of seronegative arthropathies. <h3>Objectives</h3> This study aims to identify any foot abnormalities in a healthy young population of army recruits, using clinical and digital foot scanning – pelmatographic (PLM) examination. <h3>Methods</h3> One hundred and ten (M/F:65/54) of a total of 129 new army recruits of a Military Academy in Greece participated voluntarily in the study. Subjects' informed consent and proper ethical approvals were obtained. The study conducted according to Declaration of Helsinki. A small percentage (1.12 %) reported short-term lower leg symptoms during vigorous athletic activities, the past five years. We used clinical evaluation of pes morphology on stance and compared to data obtained during the stance phase of examination using a 3400-sensors plantar pressure foot scan machine. Descriptive statistics were used for the statistical analyses. <h3>Results</h3> Agreement between clinical and pelmatographic observation was noted in 59.1% of subjects. In particular, clinical and pelmatographic normal pes was observed in 48.2% and 68.8% of subjects, respectively. High arched foot was observed in 23.6% and 17.2%, while flat foot in 23.6% and 9.7% respectively. There was no statistical difference between clinical and pelmatographic evaluation of high arched foot (chi-square test, <i>p</i>=0,815). Discrepancy between clinical and pelmatographic evaluation of flat feet was noted (<i>p=</i>0.04, OR:0.47, 95%CI:0.165-0.730). Finally, 37.3% of the participants presented foot pronation while in 60.8% subjects [M:41 (60.2%), F:27 (39.3%)] brachymetatarsia of the 1<sup>st</sup> toe (Morton's toe) was observed. <h3>Conclusion</h3> Prevalence of pes abnormalities are high and unattended in an otherwise healthy young population. These variations may predispose to future foot symptoms under specific circumstances. Digital foot pressure scanning may facilitate diagnosis and contribute to solution with foot orthotics. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1735-PARE DIETARY PRACTICE AND CHRONIC INFLAMMATORY RHEUMATIC DISEASES. WHAT DO OUR PATIENTS?
Authors: M. Labrousse, C. Alleyrat, E. Gervais
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background:</h3> <h3>Objectives</h3> Patients show interest in non-drug approaches in particular by the mode of feeding. The objectives of this study are to evaluate the prevalence of dietary changes among patients with. chronic inflammatory rheumatism, describe their practices and food designs, to compare them between the different subgroups of patients as well as describe the potential impact on care and well-being of the patients. <h3>Methods</h3> Questionnaire survey of patients followed in the Rheumatology department of Poitiers University Hospital, France, for rheumatoid arthritis or spondyloarthritis, including psoriatic arthritis. <h3>Results</h3> Two hundred and three patients were included (112 rheumatoid arthritis, 91 spondyloarthritis, including 25 psoriatic arthritis). They are 45.3% to have been informed of beneficial dietary practices, and 34.5% to have discussed the subject with a professional (13.3% with a rheumatologist). The prevalence of dietary changes is 42.9% (IC95%: [36% - 50%]), and 14.77% of patients were on a diet or taking a dietary supplement at the time of the survey. Diets mainly tested are the reduction in the consumption of dairy products, Seignalet-type diets, fasting, the gluten-free diet and the reduction in meat consumption. For the majority of patients, there was no improvement in pain, fatigue, general condition or reduction in drug intake, except with fasting (n=9) for which a decrease in drug intake was reported at 66.7% (n=7). The discussion on the subject with a health professional is a factor associated with the modification of dietary practices (p=0.001). <h3>Conclusion</h3> Changes in dietary practices concern nearly half of patients, but are only slightly in line with recent recommendations. The information by the physician is often absent and deserves to be improved. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1690 SERUM PEPTIDES AS CANDIDATE BIOMARKERS FOR RELAPSING POLYCHONDRITIS
Authors: M. Kurokawa, T. Sato, M. Sato, K. Nagai, M. Fukasawa, Y. Nagashima, T. Uchida, A. Tsutiya, K. Omoteyama, M. Arito, Y. Takakuwa, S. Ooka, N. Suematsu, K. Kawahata, Y. Yamano, T. Kato
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> For relapsing polychondritis (RP), no useful biomarkers have yet been identified. <h3>Objectives</h3> We analyzed serum peptide profiles to identify candidate biomarkers. <h3>Methods</h3> Patients with RP or rheumatoid arthritis (RA) and healthy control (HC) subjects were divided into training (RP, n=19; RA, n=21; HC, n=17) and testing (RP, n=18; RA, n=21; HC, n=18) sets. Seven patients demonstrating granulomatosis with polyangiitis (GPA) were used for validation. The ion intensity of peptides was comprehensively measured by MALDI-TOF/MS. <h3>Results</h3> 160 serum peptides were detected. In the RP group of the training set, 24, 8, and 7 peptides showed a ≥1.2-fold difference in ion intensity in comparison to the HC, RA, and HC+RA (non-RP) groups, respectively (p&lt;0.05). Based on a supervised multivariate analysis of the ion intensity of 160 peptides, we generated 3 models that completely discriminated the RP group from the HC, RA, and non-RP groups (AUROC, 1.000). By selecting 11, 9, and 14 peptides, the RP group was also completely discriminated from the 3 groups (RP/HC-11P model, RP/RA-9P model, and RP/nonRP-14P model; AUROC, 1.000). We attempted to identify the peptides with a ≥1.2-fold difference in ion intensity between the RP group and one of the 3 groups and the peptides comprising the RP/HC-11P, RP/RA-9P or RP/nonRP-14P models. Nineteen peptides were identified. Most were fragments of proteins associated with coagulation. As biomarker models for RP which consists of a few peptides, we found that 4 models consisting of 4 peptides (RP/nonRP-4P-2, -10, -11, and -38 models) provided ≥65.0% sensitivity and specificity (AUROC, 0.779-0.836) in the training and testing sets and the testing set with GPA group. Notably, the RP/nonRP-4P-2 model provided 83.3% sensitivity and 71.7% specificity in the testing set with GPA group (AUROC, 0.802). <h3>Conclusion</h3> Serum peptide profiles provided useful candidate biomarkers for RP and may be implicated in the pathophysiology of RP. <h3>Acknowledgements</h3> The authors are indebted to Ms Michiyo Katano for her technical assistance. <h3>Disclosure of Interests</h3> None Declared.
AB1779-HPR ASSESSING THE INTERNAL VALIDITY OF THE BSR PAIN MANAGEMENT FOR INFLAMMATORY ARTHRITIS QIP TOOL
Authors: A. Bhatti, L. West, N. Shenker
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Pain management is an important component of many Inflammatory Arthritis consultations. The BSR Pain Management for Inflammatory Arthritis Quality Improvement Tool uses 11 questions and 38 sub questions that assess three domains; background information (3 questions), pain management in the consultation (5 questions) and pain management in previous consultations (3 questions)[1]. The questions are based on the EULAR Guidelines for Pain Management in Inflammatory and Osteoarthritis [2]. The tool is free to use, produces results in real time in anonymised PDF form. The project is sponsored by Cambridge University Hospitals NHS Foundation Trust Audit Department (Number 2200). <h3>Objectives</h3> To assess the internal validity of the Pain Management for Inflammatory Arthritis Quality Improvement (QIP) tool 2020. <h3>Methods</h3> Two independent researchers (A &amp; B) reviewed appointment/clinic notes from 33 patients who had attended Rheumatology appointments at Addenbrooke's Hospital. 20 of these patients were found to experience pain during the consultation and the QIP tool questionnaire was used to assess their pain management. To assess the internal validity of the QIP tool; results from each reviewer were compared to generate a Cohen's Kappa Score for each question. <h3>Results</h3> The overall Kappa Score for the QIP tool was 0.75, with 570 congruent results and 190 incongruent results. The congruence was found to be high across the majority of questions. 87/190 (46%) of the incongruent scores were from just 6/38 questions. The QIP tool questions can be modified to improve clarity. There was systematic bias in the questions with lower kappa scores (A answering "Yes" and B answering "No"). <h3>Conclusion</h3> The Pain Management for Inflammatory Arthritis QIP Tool has a high internal validity as shown by the Kappa scores generated by results from two independent reviewers. To overcome the low Kappa scores on individual questions; additional guidance on how to answer specific questions may need to be provided to those filling out the questionnaire. <h3>References</h3> [1]https://addenbrookes.onlinesurveys.ac.uk/pain-management-for-inflammatory-arthritis-qip-tool-2020 [2]Geenen R, Overman CL, Christensen R, et al. EULAR recommendations for the health professional's approach to pain management in inflammatory arthritis and osteoarthritis. <i>Ann Rheum Dis</i>. 2018;77(6):797-807. doi:10.1136/annrheumdis-2017-212662 <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1742-PARE HEALTH INFORMATION UTILIZATION IN RHEUMATOID AND PSORIATIC ARTHRITIS
Authors: E. Duffey, N. Bhanusali, K. Camargo Macias, S. Beg, S. Chalise
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Technology has facilitated widespread general access to health information publicly. However not all health information available for consumption is accurate, reliable, updated, and of equal value to people seeking to be informed advocates of their own health. This cross-sectional study sought to establish the preferred resources patients with rheumatologic conditions seek out for health information. This study provides recent evidence to inform patient education, open dialogue, with the hope to improve clinical practice and patient outcomes. <h3>Objectives</h3> To describe utilization of health information preferences to inform physician-patient shared decision-making and best clinical practice. <h3>Methods</h3> From December 2019 to March 2020, 236 Rheumatoid Arthritis (RA) and 43 Psoriatic Arthritis (PsA) patients receiving care at an academic rheumatology practice in the USA were enrolled in this study. Subjects were provided with a brief, voluntary, and anonymous Qualtrics survey which gathered data on health information utilization, willingness to discuss information gathered with physicians, and desire for resources to be provided. <h3>Results</h3> Modern technology has provided multiple ways for patients to gather additional health information of variable accuracy. This information impacts patient willingness to adhere to clinical recommendations. These data show that patients seek open and honest discussion of health information gathered from other sources. A substantial percentage of patients also desire guidance towards reliable online health resources from their physicians. <h3>Conclusion</h3> Modern technology has provided multiple ways for patients to gather additional health information of variable accuracy. This information impacts patient willingness to adhere to clinical recommendations. These data show that patients seek open and honest discussion of health information gathered from other sources. A substantial percentage of patients also desire guidance towards reliable online health resources from their physicians. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1711 EVALUATION OF KNOWLEDGE AND OBSERVANCE OF PRESCRIBED TREATMENTS FOR HOSPITALIZED PATIENTS IN A RHEUMATOLOGY DEPARTMENT
Authors: H. Tebaa, H. Arabi, A. Mougui, I. El Bouchti
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Patients' knowledge of their treatment is part of therapeutic education programs. <h3>Objectives</h3> We studied this knowledge in patients hospitalized in a rheumatology department and the impact on therapeutic compliance. <h3>Methods</h3> We conducted a monocentric prospective observational study. 104 Patients of the rheumatology department who were major and autonomous with their treatments had to answer a questionnaire in 2 parts: the first part concerned the global knowledge of their medication formalized in 4 criteria (name, indication, dosage, specificity), a global knowledge score on 4 points was elaborated with the 4 previous criteria. The second part evaluated therapeutic compliance with the Morisky test. <h3>Results</h3> 104 patients were included. Women represented 71% and men 29%. The middle socioeconomic statut was found in 33% of cases. Chronic pathologies represented 72%. The most prescribed drug classes were: synthetic conventional drugs or csDMARDs (methotrexate, sulfasalazine) in 51% of cases, corticosteroid therapy in 69%, proton pump inhibitors in 20%, anti-hypertensives in 19%, and anti-arthritis drugs in 13%, non-steroidal anti-inflammatory drugs in 23%, topical treatments in 45%, oral antidiabetics in (17%), insulin in 6%, analgesics level 1 in (60%) and level 2 in (5%), bisphosphonates in (5%), pregabalin in (13%). Patients who had completed a maximum global knowledge score (score = 4) represented 16%. The mean compliance score (measured by Morisky test) was 6.48 ± 1.41. A significant association was found between global knowledge score and male gender (p=0.001). The compliance score was negatively correlated with age (0.01; rs -0.65) and number of prescription drugs (0.01 rs -0.65) (p 0.014; rs -0.57), and positively correlated with the duration of disease progression (p 0.001; rs 0.87). No relationship was found between knowledge and compliance (p = 0.15). <h3>Conclusion</h3> The utilization of a score could be a method to evaluate knowledge and to adapt the content of educational actions to increase adherence to treatments. <h3>Reference</h3> [1]Dunkelman H. Patients' knowledge of their condition and treatment: how it might be improved.BMJ. 1979 Aug 4;2(6185):311-4. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1743-PARE PUBLIC INTEREST IN LUPUS IN AFRICA
Authors: A. Guiga, M. Ansar, A. Amara, Y. Boussoukaya, B. Y. Wissal, A. Atig, N. Ghannouchi
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Accessibility to internet has allowed people to have a better knowledge of Systemic lupus erythematosus (SLE), however, this interest in doing research is influenced by several factors, including socio-economic conditions. Google Trends (GT) is the most popular tool for examining online behavior because it provides information regarding trends and changes in online interest at certain times during a particular period. <h3>Objectives</h3> The aim of this study was to use the Google Trends data to evaluate the public interest in Systemic lupus erythematosus (SLE) in different African countries and to assess people's interest in Africa comparing to worldwide. <h3>Methods</h3> Google Trends provides the relative interest of Google Searches (RSV), on a range of 0–100. We analysed a large amount of data generated by Google Trends concerning the search of the word 'lupus' in a 7-year web-based research (2016-2022) in Africans' countries. Student's t-test was used to compare means. Analyses were performed with SPSS 21.0. P values less than 0.05 were considered statistically significant. <h3>Results</h3> Googling "lupus" was variable depending on the country. The mean annually research volume (RSV) in Africain countries was 18.20±3.92. Annual RSV was more important in Morocco50.89±16.52, Algeria 49.19±23.84. There was a significant difference in the mean annually research volume between African countries and all over the word (versus 50.86± 14.58, p&lt;10-3). (Figure1) <h3>Conclusion</h3> Google Trends allows us to find useful information about SLE on the internet. However lack of internet coverage, low socio-economic level and low education level can explain this difference between African countries and the rest of the world. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.
AB1780-HPR FIBROMYALGIA PATIENTS’ EXPERIENCES AFTER ONE-WEEK SELF-MANAGEMENT PROGRAMME FOUR TO TEN MONTHS AFTER DISCHARGE: A QUALITATIVE STUDY
Authors: B. Hamnes
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> The European League Against Rheumatism (EULAR) emphasizes in its guidelines for the treatment of fibromyalgia (FM) that Health professional should aim to improve health-related quality of life, which often requires a combination of non-pharmacological and pharmacological treatment methods. Non-pharmacological approaches have been shown to be effective In this study, a multidisciplinary self-management programme (SMP) was used to treat patients with (FM). <h3>Objectives</h3> To investigate and understand the experiences of individuals with FM who participated in a one-week SMP. <h3>Methods</h3> A qualitative study using semi-structured interviews was used to investigate the participants' experiences. A total of 22 women and 2 men with FM were interviewed 4 to 10 months after participating in a one-week SMP. The participants' goals and action plans after the SMP were used together with an interview guide. All the interviews were audio-recorded, transcribed verbatim and analysed using thematic analyses. The large body of material is divided into three sub-studies. The first sub-study is presented here. <h3>Results</h3> The mean age of the participants was 54.7 years (range 32–68). The participants' experiences were categorized into four main themes: recognition of the diagnosis, a turning point for a better life, changing one's way of thinking and having control over one's own life. Giving up the past was one description that the participants used as a way of changing their mindset. They could then focus more on the present and the future. To have control over their own lives, it became important to accept the opportunities and limitations they had in everyday life. <h3>Conclusion</h3> Four to ten months after completing the SMP, the participants in this study experienced that they were taken seriously with their FM diagnosis. The participants had attained a heightened awareness of what they could do to take control and manage their disease and daily life. <h3>Acknowledgements</h3> The author would like to thank all the informants who shared their experiences. The study was supported by the Norwegian Fibromyalgia Association and the Norwegian Rheumatism Association. <h3>Disclosure of Interests</h3> None Declared.