tbuckley/cabot-search huggingface dataset:
Accuracy of Expected Symptoms and Subsequent Quality of Life Measures Among Adults With COPD
Authors: Joanna L. Hart, Amy E. Summer, Lon Ogunduyile, Folasade C. Lapite, David Hong, Casey Whitman, Bryan S. Blette, Michael O. Harhay, Scott D. Halpern
Journal: JAMA Network Open (2023)

Importance Patients’ expectations for future health guide their decisions and enable them to prepare, adapt, and cope. However, little is known about how inaccurate expectations may affect patients’ illness outcomes. Objective To assess the association between patients’ expectation inaccuracies and health-related quality of life. Design, Setting, and Participants This cohort study of patients with severe chronic obstructive pulmonary disease (COPD) was conducted from 2017 to 2021, which included a 24-month follow-up period. Eligible participants received outpatient primary care at pulmonary clinics of a single large US health system. Data were analyzed between 2021 and 2023. Exposure Expectation accuracy, measured by comparing patients’ self-reported expectations of their symptom burden with their actual physical and emotional symptoms 3, 12, and 24 months in the future. Main Outcome and Measure Health-related quality of life, measured by the St George’s Respiratory Questionnaire-COPD at 3, 12, and 24 months. Results A total of 207 participants were included (median age, 65.5 years [range, 42.0-86.0 years]; 120 women [58.0%]; 118 Black [57.0%], 79 White [38.2%]). The consent rate among approached patients was 80.0%. Most patients reported no or only limited discussions of future health and symptom burdens with their clinicians. Across physical and emotional symptoms and all 3 time points, patients’ expectations were more optimistic than their experiences. There were no consistent patterns of measured demographic or behavioral characteristics associated with expectation accuracy. Regression models revealed that overoptimistic expectations of future burdens of dyspnea (linear regression estimate, 4.68; 95% CI, 2.68 to 6.68) and negative emotions (linear regression estimate, −3.04; 95% CI, −4.78 to 1.29) were associated with lower health-related quality of life at 3 months after adjustment for baseline health-related quality of life, forced expiratory volume over 1 second, and interval clinical events ( P &amp;amp;lt; .001 for both). Similar patterns were observed at 12 months (dyspnea: linear regression estimate, 2.41; 95% CI, 0.45 to 4.37) and 24 months (negative emotions: linear regression estimate, −2.39; 95% CI, −4.67 to 0.12; dyspnea: linear regression estimate, 3.21; 95% CI, 0.82 to 5.60), although there was no statistically significant association between expectation of negative emotions and quality of life at 12 months. Conclusions and Relevance In this cohort study of patients with COPD, we found that patients are overoptimistic in their expectations about future negative symptom burdens, and such inaccuracies were independently associated with worse well-being over time. Developing and implementing strategies to improve patients’ symptom expectations may improve patient-centered outcomes.
Antibiotics for Acute Sinusitis in Children—Reply
Authors: Nader Shaikh
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gut-microbiota prompt activation of natural killer cell on alcoholic liver disease
Authors: Jung A Eom, Jin-Ju Jeong, Sang Hak Han, Goo Hyun Kwon, Kyeong Jin Lee, Haripriya Gupta, Satya Priya Sharma, Sung-Min Won, Ki-Kwang Oh, Sang Jun Yoon, Hyun Chae Joung, Kyung Hwan Kim, Dong Joon Kim, Ki Tae Suk
Journal: Gut Microbes (2023)

The liver is rich in innate immune cells, such as natural killer (NK) cells, natural killer T cells, and Kupffer cells associated with the gut microbiome. These immune cells are dysfunctional owing to alcohol consumption. However, there is insufficient data on the association between immune cells and gut microbiome in alcoholic liver disease (ALD). Therefore, the purpose of this study was to evaluate the effects of probiotic strains on NK cells in ALD patients. In total, 125 human blood samples [control (n = 22), alcoholic hepatitis (n = 43), and alcoholic cirrhosis (n = 60]) were collected for flow cytometric analysis. C57BL/6J mice were divided into four groups (normal, EtOH-fed, and 2 EtOH+strain groups [Phocaeicola dorei and Lactobacillus helveticus]). Lymphocytes isolated from mouse livers were analyzed using flow cytometry. The frequency of NK cells increased in patients with alcoholic hepatitis and decreased in patients with alcoholic cirrhosis. The expression of NKp46, an NK cell-activating receptor, was decreased in patients with alcoholic hepatitis and increased in patients with alcoholic cirrhosis compared to that in the control group. The number of cytotoxic CD56dimCD16+ NK cells was significantly reduced in patients with alcoholic cirrhosis. We tested the effect of oral administration P. dorei and L. helveticus in EtOH-fed mice. P. dorei and L. helveticus improved liver inflammation and intestinal barrier damage caused by EtOH supply and increased NK cell activity. Therefore, these observations suggest that the gut microbiome may ameliorate ALD by regulating immune cells.
Medicare Physician Fee Schedule
Authors: Jack S. Resneck
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CB1R dysfunction of inhibitory synapses in the ACC drives chronic social isolation stress-induced social impairments in male mice
Authors: Baolin Guo, Kaiwen Xi, Honghui Mao, Keke Ren, Haoxiang Xiao, Nolan D. Hartley, Yangming Zhang, Junjun Kang, Yingying Liu, Yuqiao Xie, Yongsheng Zhou, Yuanyuan Zhu, Xia Zhang, Zhanyan Fu, Jiang-Fan Chen, Hailan Hu, Wenting Wang, Shengxi Wu
Journal: Neuron (2023)
Extended platelet‐rich fibrin
Authors: Richard J. Miron, Michael A. Pikos, Nathan E. Estrin, Masako Kobayashi‐Fujioka, Alan Rene Espinoza, Hussein Basma, Yufeng Zhang
Journal: Periodontology 2000 (2023)

Abstract Platelet‐rich fibrin (PRF) has been characterized as a regenerative biomaterial that is fully resorbed within a typical 2–3 week period. Very recently, however, a novel heating process was shown to extend the working properties of PRP/PRF from a standard 2–3 week period toward a duration of 4–6 months. Numerous clinicians have now utilized this extended‐PRF (e‐PRF) membrane as a substitute for collagen barrier membranes in various clinical applications, such as guided tissue/bone regeneration. This review article summarizes the scientific work to date on this novel technology, including its current and future applications in periodontology, implant dentistry, orthopedics and facial aesthetics. A systematic review was conducted investigating key terms including “Bio‐Heat,” “albumin gel,” “albumin‐PRF,” “Alb‐PRF,” “extended‐PRF,” “e‐PRF,” “activated plasma albumin gel,” and “APAG” by searching databases such as MEDLINE, EMBASE and PubMed. Findings from preclinical studies demonstrate that following a simple 10‐min heating process, the transformation of the liquid plasma albumin layer into a gel‐like injectable albumin gel extends the resorption properties to at least 4 months according to ISO standard 10 993 (subcutaneous animal model). Several clinical studies have now demonstrated the use of e‐PRF membranes as a replacement for collagen membranes in GTR/GBR procedures, closing lateral windows in sinus grafting procedures, for extraction site management, and as a stable biological membrane during recession coverage procedures. Furthermore, Alb‐PRF may also be injected as a regenerative biological filler that lasts extended periods with advantages in joint injections, osteoarthritis and in the field of facial aesthetics. This article highlights the marked improvement in the stability and degradation properties of the novel Alb‐PRF/e‐PRF technology with its widespread future potential use as a potential replacement for collagen membranes with indications including extraction site management, GBR procedures, lateral sinus window closure, recession coverage among others, and further highlights its use as a biological regenerative filler for joint injections and facial aesthetics. It is hoped that this review will pioneer future opportunities and research development in the field, leading to further progression toward more natural and less costly biomaterials for use in medicine and dentistry.
Phosphate Limitation Responses in Marine Green Algae Are Linked to Reprogramming of the tRNA Epitranscriptome and Codon Usage Bias
Authors: Elisabeth Hehenberger, Jian Guo, Susanne Wilken, Kenneth Hoadley, Lisa Sudek, Camille Poirier, Richard Dannebaum, Edward Susko, Alexandra Z Worden
Journal: Molecular Biology and Evolution (2023)

Marine algae are central to global carbon fixation, and their productivity is dictated largely by resource availability. Reduced nutrient availability is predicted for vast oceanic regions as an outcome of climate change; however, there is much to learn regarding response mechanisms of the tiny picoplankton that thrive in these environments, especially eukaryotic phytoplankton. Here, we investigate responses of the picoeukaryote Micromonas commoda, a green alga found throughout subtropical and tropical oceans. Under shifting phosphate availability scenarios, transcriptomic analyses revealed altered expression of transfer RNA modification enzymes and biased codon usage of transcripts more abundant during phosphate-limiting versus phosphate-replete conditions, consistent with the role of transfer RNA modifications in regulating codon recognition. To associate the observed shift in the expression of the transfer RNA modification enzyme complement with the transfer RNAs encoded by M. commoda, we also determined the transfer RNA repertoire of this alga revealing potential targets of the modification enzymes. Codon usage bias was particularly pronounced in transcripts encoding proteins with direct roles in managing phosphate limitation and photosystem-associated proteins that have ill-characterized putative functions in "light stress." The observed codon usage bias corresponds to a proposed stress response mechanism in which the interplay between stress-induced changes in transfer RNA modifications and skewed codon usage in certain essential response genes drives preferential translation of the encoded proteins. Collectively, we expose a potential underlying mechanism for achieving growth under enhanced nutrient limitation that extends beyond the catalog of up- or downregulated protein-encoding genes to the cell biological controls that underpin acclimation to changing environmental conditions.
Microenvironment‐Driven Fenton Nanoreactor Enabled by Metal‐Phenolic Encapsulation of Calcium Peroxide for Effective Control of Dental Caries
Authors: Xiaoru Yang, Jinlong Shao, Yandi Zhang, Ting Wang, Shaohua Ge, Jianhua Li
Journal: Advanced Healthcare Materials (2023)

Caries are one of the most common oral diseases caused by pathogenic bacterial infections, which are widespread and persistently harmful to human health. Using nanoparticles to invade biofilms and produce reactive oxygen species (ROS) in situ is a promising strategy for killing bacteria and disrupting the structure of biofilms. In this work, a biofilm-targeting Fenton nanoreactor is reported that can generate ROS responsive to the cariogenic microenvironment. The nanoreactor is constructed by metal-phenolic encapsulation of calcium peroxide (CaO
An atypical presentation of visceral leishmaniasis mimicking multiple myeloma relapse
Authors: Giulia Benevolo, Giuseppe Bertuglia, Sara Bringhen, Francesca Maletta, Benedetto Bruno
Journal: American Journal of Hematology (2023)

Giulia Benevolo: received honoraria from Celgene, Novartis, Janssen, and Bristol Myers Squibb, and has served on the board of directors or advisory committees for Celgene, Novartis, Janssen, and Bristol Myers Squibb. Sara Bringhen: received honoraria from Celgene, Amgen, Janssen, and Bristol Myers Squibb, has served on the board of directors or advisory committees for Celgene, Amgen, Janssen, GlaxoSmithKline, Sanofi, and Pfizer, and has received consultancy fees from Janssen, Takeda, Celgene, and Bristol Myers Squibb. Benedetto Bruno, Giuseppe Bertuglia and Francesca Maletta have no conflicts of interest to declare.
Facile Physicochemical Reprogramming of PEG‐Dithiolane Microgels
Authors: Benjamin R. Nelson, Bruce E. Kirkpatrick, Nathaniel P. Skillin, Nikolas Di Caprio, Joshua S. Lee, Lea Pearl Hibbard, Grace K. Hach, Alex Khang, Timothy J. White, Jason A. Burdick, Christopher N. Bowman, Kristi S. Anseth
Journal: Advanced Healthcare Materials (2023)

Granular biomaterials have found widespread applications in tissue engineering, in part because of their inherent porosity, tunable properties, injectability, and 3D printability. However, the assembly of granular hydrogels typically relies on spherical microparticles and more complex particle geometries have been limited in scope, often requiring templating of individual microgels by microfluidics or in-mold polymerization. Here, we use dithiolane-functionalized synthetic macromolecules to fabricate photopolymerized microgels via batch emulsion, and then harness the dynamic disulfide crosslinks to rearrange the network. Through unconfined compression between parallel plates in the presence of photoinitiated radicals, we transform the isotropic microgels are transformed into disks. Characterizing this process, we find that the areas of the microgel surface in contact with the compressive plates are flattened while the curvature of the uncompressed microgel boundaries increases. When cultured with C2C12 myoblasts, cells localize to regions of higher curvature on the disk-shaped microgel surfaces. This altered localization affects cell-driven construction of large supraparticle scaffold assemblies, with spherical particles assembling without specific junction structure while disk microgels assemble preferentially on their curved surfaces. These results represent a unique spatiotemporal process for rapid reprocessing of microgels into anisotropic shapes, providing new opportunities to study shape-driven mechanobiological cues during and after granular hydrogel assembly.
Amino Acids Fueling <scp>Fibroblast‐Like</scp> Synoviocyte Activation and Arthritis By Regulating Chemokine Expression and Leukocyte Migration
Authors: Thomas Karonitsch, Victoria Saferding, Markus Kieler, Karolina von Dalwigk, Anela Tosevska, Gerwin Heller, Mirjam Dellinger, Birgit Niederreiter, Felix Kartnig, Carl W. Steiner, Philippe Georgel, Hans P. Kiener, Josef S. Smolen, Adelheid Korb‐Pap, Michael Bonelli, Daniel Aletaha, Stephan Blüml
Journal: Arthritis & Rheumatology (2023)

Objective We analyzed the impact of amino acid (AA) availability on the inflammatory response in arthritis. Methods We stimulated rheumatoid arthritis (RA) fibroblast‐like synoviocytes (FLSs) with tumor necrosis factor (TNF) in the presence or absence of proteinogenic AAs and measured their response by QuantSeq 3′ messenger RNA sequencing, quantitative polymerase chain reaction, and enzyme‐linked immunosorbent assay. Signal transduction events were determined by Western blot. We performed K/BxN serum transfer arthritis in mice receiving a normal and a low‐protein diet and analyzed arthritis clinically and histologically. Results Deprivation of AAs decreased the expression of a specific subset of genes, including the chemokines CXCL10, CCL2, and CCL5 in TNF‐stimulated FLSs. Mechanistically, the presence of AAs was required for the TNF‐induced activation of an interferon regulatory factor 1 (IRF1)‐STAT1 signaling circuit that drives the expression of chemotactic factors. The expression of IRF1 and the IRF1‐dependent gene set in FLSs was highly correlated with the presence of inflammatory cells in human RA, emphasizing the important role of this AA‐dependent pathway in inflammatory cell recruitment to the synovial tissue. Finally, we show that mice receiving a low‐protein diet expressed less IRF1 in the inflamed synovium and consequently developed reduced clinical and histologic signs of arthritis. Conclusion AA deprivation reduces the severity of arthritis by suppressing the expression of IRF1‐STAT1–driven chemokines, which are crucial for leukocyte recruitment to the arthritic joint. Overall, our study provides novel insights into critical determinants of inflammatory arthritis and may pave the way for dietary intervention trials in RA. image
Challenging the norm: Epicutaneous immunotherapy for canine atopic dermatitis
Authors: Marta Sofia das Neves Pinto, Solange Judite Roque Coelho Alves Gil, Laura Ramió‐Lluch, Vanessa Merta Schmidt, Hugo Miguel Lino Pereira, Beatriz Amaral Pinto Fernandes, Ana Filipa Bizarro Camões, Mário Morais‐Almeida, Berta Maria Fernandes Ferreira São Braz, Joana Marques Marto, Ana Mafalda Gonçalves Xavier Félix Lourenço
Journal: Allergy (2023)

The data that support the findings of this study are available from the corresponding author upon reasonable request. Data S1 Table S1 Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Exploring the thaumatin‐like protein (<scp>TLP</scp>) as a candidate cannabis allergen in North‐Western Europe
Authors: D. G. Ebo, H. P. Rihs, C. H. Mertens, A. L. Van Gasse, M. L. van der Poorten, M. M. Hagendorens, V. Sabato, J. Elst
Journal: Allergy (2023)

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Data S1: Supporting Information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Correspondence to “Basophil activation test as predictor of severity and threshold of allergic reactions to egg”
Authors: Didier G. Ebo, Jessy Elst, Athina L. Van Gasse, Christel Mertens, Vito Sabato
Journal: Allergy (2023)

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
Toward Type I/II ROS Generation Photoimmunotherapy by Molecular Engineering of Semiconducting Perylene Diimide
Authors: Jie Zhang, Wen Ma, Haifen Luo, Kangxin Zhang, Jingqi Lv, Lizhi Jiang, Yanli Huang, Jibing Song, Zhen Yang, Wei Huang
Journal: Advanced Healthcare Materials (2023)

Abstract As prospective phototheranostic agents for cancer imaging and therapy, semiconducting organic molecule‐based nanomedicines are developed. However, near‐infrared (NIR) emission, and tunable type I (O 2 • − ) and type II ( 1 O 2 ) photoinduced reactive oxygen species (ROS) generation to boost cancer photoimmunotherapy remains a big challenge. Herein, a series of D–π–A structures, NIR absorbing perylene diimides (PDIs) with heavy atom bromide modification at the bay position of PDIs are prepared for investigating the optimal photoinduced type I/II ROS generation. The heavy atom effect has demonstrated a reduction of molecular ∆ E ST and promotion of the intersystem crossing processes of PDIs, enhancing the photodynamic therapy (PDT) efficacy. The modification of three bromides and one pyrrolidine at the bay position of PDI (TBDT) has demonstrated the best type I/II PDT performance by batch experiments and theoretical calculations. TBDT based nanoplatforms (TBDT NPs) enable type I/II PDT in the hypoxic tumor microenvironment as a strong immunogenic cell death (ICD) inducer. Moreover, TBDT NPs showing NIR emission allow in vivo bioimaging guided phototherapy of tumor. This work uses novel PDIs with adjustable type I/II ROS production to promote antitumor immune response and accomplish effective tumor eradication, consequently offering molecular guidelines for building high‐efficiency ICD inducers.
Correction: Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover
Authors: Tomáš Brabec, Martin Schwarzer, Katarína Kováčová, Martina Dobešová, Dagmar Schierová, Jiří Březina, Iva Pacáková, Dagmar Šrůtková, Osher Ben-Nun, Yael Goldfarb, Iva Šplíchalová, Michal Kolář, Jakub Abramson, Dominik Filipp, Jan Dobeš
Journal: The Journal of Experimental Medicine (2023)