POS1137 CORRELATIONS BETWEEN CLINICAL PARAMETERS AND SERUM CYTOKINE LEVELS IN OSTEOARTHRITIS PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: E. Trifonova, E. Zonova, O. Sazonova
Journal: Annals of the Rheumatic Diseases (2022)

Background Type 2 diabetes mellitus (T2DM) is one of frequent factor that can influence on development and progression of osteoarthritis (OA) and has similar mechanisms of immunopathogenesis. Objectives To explore the symptoms and the proinflammatory serum cytokine levels in OA (hand, knee, and hip) patients with T2DM and to estimate relationships between clinical and immunological features. Methods Patients who participated in this study (n=137) were divided in two groups: patients with bilateral hand, knee and hip OA (n=56) and T2DM and control group (n=81) which had only hand, knee and hip OA without such comorbidity. All patients were comparable in age, sex and duration of OA. We assessed serum cytokine levels (IL-1b, IL-6, IL-10, IL-18), NO including adipokines such as adiponectin, leptin and C-reactive protein (CRP), erythrocyte sedimentation rate (ESR). Various symptoms of OA and mental health were measured using visual analog scale (VAS), Functional Index for Hand Osteoarthritis (FIHOA), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC Knee/Hip), Knee injury and Osteoarthritis Outcome Score – (KOOS), Hip injury and Osteoarthritis Outcome Score – (HOOS) and with short form 36 (SF-36), Psychological Health Questionnaire (PHQ9), Coping Pain Strategy Questionnaire (CSQ). We used U-Mann-Whitney test to detect differences between groups. Correlation was assessed using Spearman correlation coefficient (r s ). Results Patients with OA and T2DM are characterized by the prevalence of KOOS symptoms (median (Me) 58,3; interquartile range (IQR) 50–71,5; р&lt;0.001), WOMAC Knee Total (Me 1327; IQR 930,8–1546; р&lt;0.001) and low values of mental health (SF-MH) (Me 48; IQR 33–56; р&lt;0.001). We found increase of IL 6 (p = 0.0018), IL18 (p = 0.0006), NO (p &lt; 0.0001) levels in the blood serum of patients with OA and comorbidity. Patients with OA and T2DM had high ESR level (p &lt; 0.0001) and leptin level (p = 0,0002) also. Correlation analysis identified the relationships between clinical parameters and such cytokines as IL-1b, IL-6, IL-10 and leptin, CRP in OA patients with T2DM. Some data are presented (Table 1). Conclusion Such comorbidity as OA and T2DM has clinical and laboratory features of progression of OA. Such immunological factors as serum cytokines concentrations, adipokines, CRP are linked with the severity of T2DM-associated OA. A different variation of correlations may suppose role of this proinflammatory factors in the pathogenesis of this OA phenotype. These data should be verified by larger studies. References [1]Veronese N. et al. Type 2 diabetes mellitus and osteoarthritis //Seminars in arthritis and rheumatism. – WB Saunders, 2019. – Т. 49. – №. 1. – С. 9-19. [2]Louati K. et al. Association between diabetes mellitus and osteoarthritis: systematic literature review and meta-analysis //RMD open. – 2015. – Т. 1. – №. 1. – С. e000077. [3]Leaverton, P.E. Does diabetes hide osteoarthritis pain? / P.E. Leaverton, J. Peregoy, L. Fahlman et al. / Med. Hypotheses. – 2012. – Vol. 78, N 4. – P. 4714. Disclosure of Interests None declared