tbuckley/cabot-search huggingface dataset:
Air Pollution and Health Effects: A Study of Medical Visits among Children in Santiago, Chile
Authors: Bart D. Ostro, Gunnar S. Eskeland, Jose M. Sanchez, Tarhan Feyzioglu
Journal: Environmental Health Perspectives (1999)

Many epidemiological studies conducted in the last several years have reported associations between exposure to airborne particulate matter, measured as PM10 (<10 microm in diameter), and daily morbidity and mortality. However, much of the evidence involves effects on the elderly population; there is less evidence about the effects of particulates on children, especially those under 2 years of age. To examine these issues, we conducted time-series analyses of 2 years of daily visits to primary health care clinics in Santiago, Chile, where counts were computed for either upper or lower respiratory symptoms and for cohorts of children 3-15 years of age and below age 2. Daily PM10 and ozone measurements and meteorological variables were available from instruments located in downtown Santiago. The multiple regression analysis indicates a statistically significant association between PM10 and medical visits for lower respiratory symptoms in children ages 3-15 and in children under age 2. PM10 is also associated with medical visits related to upper respiratory symptoms in the older cohort, while ozone is associated with visits related to both lower and upper respiratory symptoms in the older cohort. For children under age 2, a 50- microg/m3 change in PM10 (the approximate interquartile range) is associated with a 4-12% increase in lower respiratory symptoms. For children 3-15 years of age, the increase in lower respiratory symptoms ranges from 3 to 9% for a 50- microg/m3 change in PM10 and 5% per 50 ppb change in ozone. These magnitudes are similar to results from studies of children undertaken in Western industrial nations.
Response and progression in recurrent malignant glioma
Authors: Kenneth R. Hess, Eric T. Wong, Kurt A. Jaeckle, Athanassios P. Kyritsis, Victor A. Levin, Michael D. Prados, W. K. Alfred Yung
Journal: Neuro-Oncology (1999)

In this article we report the results of a study of the relationship between response and progression in 375 patients with recurrent glioma enrolled in phase II chemotherapy trials.We reviewed the records of patients from 8 consecutive phase II trials, including 225 patients with recurrent glioblastoma multiforme and 150 with recurrent anaplastic astrocytoma.Median age was 45 years (range, 15-82) and median Karnofsky performance score was 80 (range, 60-100).Forty-one patients (11%) had more than two prior resections and/or more than two prior chemotherapy regimens.Best response was complete (n = 1) or partial (n = 33) in 34 patients (9%).Median time to response was 14 weeks, and median response duration was 44 weeks.Simon-Makuch estimates for 52-week progression-free survival for patients progression-free at 13 weeks were 48% for response and 28% for nonresponse.When response was treated as a time-dependent covariate in a Cox proportional hazards regression analysis, response was associated with signi cantly lower failure rates (hazard ratio 0.5; 95% con dence interval 0.3-0.8;P = 0.0016).This study showed that response in recurrent glioma is associated with a signi cant reduction in progression rates.
Shock at the Front.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NIMH/NIH Consensus Development Conference statement. Mood disorders: pharmacologic prevention of recurrences. Consensus Development Panel
Journal: American Journal of Psychiatry (1985)

This report represents the consensus of a panel of representatives from psychiatry, psychology, pharmacology, epidemiology, internal medicine, and the general public regarding the use of pharmacologic agents to prevent recurrences of mood disorders. The panel concluded that recurrent mood disorders, which have a high prevalence and serious consequences, are underdiagnosed and undertreated. Applying appropriate strategies to the management and use of pharmacologic agents will enhance the likelihood of compliance and the prevention of recurrence with a minimum of bothersome side effects. Such strategies should be used within the context of a supportive relationship among doctor, patient, and family.
Clinical Practice Guideline Development and Antitrust Law—Reply
Authors: John Kraemer
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Occupational Silicosis—Ohio, 1989-1994
Journal: JAMA (1995)

Silicosis is a chronic lung disease associated with the inhalation and pulmonary deposition of dust that contains crystalline silica. Through the Sentinel Event Notification System for Occupational Risks (SENSOR)* program, CDC's National Institute for Occupational Safety and Health (NIOSH) is assessing practical models for implementing state-based surveillance of silicosis and linking follow-up intervention activities to surveillance reports. From 1989 through 1992, the Ohio Department of Health (ODH) SENSOR program identified silicosis cases through reports of Bureau of Workers' Compensation (BWC) claims, physician reports, and death certificates. The addition in 1993 of hospital discharge reports as an ascertainment source resulted in a substantial increase in the number of silicosis case reports identified annually (Table 1). This report describes the investigation of a case of occupational silicosis in Ohio and summarizes the impact of hospital-based reporting on surveillance for silicosis in Ohio during 1993-1994.
Empty Pockets
Authors: Kevan Pickrel
Journal: Annals of Internal Medicine (2003)

On Being a Doctor16 September 2003Empty PocketsKevan Pickrel, MDKevan Pickrel, MDFrom Phoenix, AZ 85020-2450.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-6-200309160-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Many of the experiences in our work we smooth and shape in the retelling like pebbles being polished by the tides. Some are more valuable for their sharp edges and the pain and lesson they bring by holding them tight.I spent part of my residency training at a city Veterans Hospital. Overnight call meant perpetual motion punctuated by frantic episodes of critical care. On this night we had done well, and by the time the first code arrest sounded overhead we all had managed to keep our heads above the tide. We arrived to the medical intensive care unit, ... Author, Article, and Disclosure InformationAffiliations: From Phoenix, AZ 85020-2450.Corresponding Author: Kevan Pickrel, MD, 9100 N. Second Street, Suite 221, Phoenix, AZ 85020-2450; e-mail, [email protected]net. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 September 2003Volume 139, Issue 6Page: 525KeywordsBlood pressureHeartIntubationIschemiaMedical intensive care unitsNursesPharynxResidencyStomachSystole ePublished: 16 September 2003 Issue Published: 16 September 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1956)

STATED MEETING OF THE COUNCILA stated meeting of the Council will be held in John Ware Hall, Boston Medical Library, 8 Fenway, Boston, on Wednesday, October 3, at 10:30 a.m. This meeting will be followed by the Cotting Luncheon.Business:Call to order at 10:30 a.m.Presentation of record of meeting held May 21, 1956, as published in Vol. 255, Supplement No. 1, July 5, 1956, of the New England Journal of Medicine.Reports of standing and special committees.Such other business as may legally come before this meeting.Robert W. Buck, M.D.SecretaryCOMMITTEE ON MATERNAL WELFAREPulmonary . . .
Superior vena cava syndrome. Clinical management
Authors: R. Goodman
Journal: JAMA (1975)

† Superior vena cava syndrome (SVCS) is an acute or subacute oncologic emergency with typical clinical features. The syndrome is almost invariably secondary to a malignant process. The treatment of choice is irradiation, but in resistant cases or in those instances in which radiation tolerance is achieved, either surgery or chemotherapy, or both, may play a crucial role. The major pitfalls in management relate to attempts to establish the site of obstruction and to obtain specific tissue diagnosis. (<i>JAMA</i>231:58-61, 1975)
Family consent to orders not to resuscitate
Authors: Grant E. Steffen
Journal: JAMA (1991)

<h3>To the Editor.—</h3> Two recent articles<sup>1,2</sup>argue that when a physician determines that cardiopulmonary resuscitation (CPR) would be futile, then the physician should be allowed to write the "do not resuscitate" (DNR) order without permission from the competent patient or the incompetent patient's surrogate. In the first article, Hackler and Hiller addressed the hospital policy that requires this permission and argued that not only when CPR is determined to be futile but also when the physician believes that the burdens of CPR clearly outweigh the benefits, the physician should be allowed to write the DNR order without the surrogate's permission. I agree with Hackler and Hiller and have argued<sup>3</sup>that treatment goals are legitimate if, among other things, they are empirically possible and ethically justified. In the two cases that Hackler and Hiller describe, the surrogates' treatment goals, presumably successful resuscitation, were not legitimate. In both cases, resuscitation
NIH Budget Stalls
Authors: B. Vastag
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Synovial Cysts and Rupture of the Knee Joint in Rheumatoid Arthritis: An Arthrographic Study
Authors: A. P. Hall, J. T. Scott
Journal: Annals of the Rheumatic Diseases (1966)

19th century descriptions of cysts in the popliteal region or calf communicating with the knee included those of Adams (1840) and Baker (1877, 1885), and these phenomena are often called Baker's cysts.Baker clearly recognized the possibility of acute rupture occurring in these cysts.Recently Dixon and Grant (1964) have described five patients with rheumatoid arthritis in whom they diagnosed acute synovial rupture of a knee effusion into the calf.The present paper describes the use of contrast arthrography in studying twenty patients who presented during the past 2 years with either intact cysts of the popliteal region or calf, or synovial rupture of the knee joint or of a popliteal cyst.This method of examination has been used in single patients or in small groups by Beatty (1959), Harvey and Corcos (1960), and Tait, Bach, and Dixon (1965).Method
The Mitochondrion
Authors: D. F. Tapley, D. V. Kimberg, J. L. Buchanan
Journal: New England Journal of Medicine (1967)

DURING the past few decades the mitochondrion, as a self-contained unit within the cell, has been a magnificent tool in the hands of biochemists, physiologists and anatomists in their attempts to unravel the complexities of cellular function. It appears that it will continue to be. This review will attempt to present our current knowledge of the structure and function of the mitochondrion and of the alterations that may be induced by a multitude of factors, including the hormones.The first recognition of mitochondria as distinct organelles within the cytoplasm occurred less than a hundred years ago. The name (derived from . . .
Cancer of the urogenital tract: prostatic cancer. Comment: the detection of occult metastatic cancer by radioactive bone scans
Authors: P. Rubin
Journal: JAMA (1969)

The ability to detect occult metastases at the time of initial appearance of the primary tumor is of major importance in the management of the patient with cancer. Prostate cancer is a particularly suitable example in discussion of this problem; it shares the same role in the male as breast cancer has in the female, accounting for 60% to 70% of all bone metastases.<sup>42</sup>The majority of patients with prostate cancer have either occult or detectable osseous involvement at the time of first diagnosis. The effect of such knowledge on making decisions or on treating the primary cancer by radical surgery, radical radiation therapy, and/or hormonal manipulation can be profound. The unique importance of acid phosphatase has been discussed; however, elevation of levels of this enzyme fails to distinguish local extracapsular spread from metastatic cancer. The value of radioisotope scans in detecting occult metastatic bone cancer has received increasing
Book Reviews
Journal: Allergy (1987)

Book reviewed in this article: Marks, R. &amp; Plewig, G.: Skin models. Models to study function and disease of skin. Ring, J. &amp; Burg, G. (eds.): New trends in allergy. II. Shakib , F. (ed.): Basic and clinical aspects of IgG subclasses. Monographs in allergy, volume 19.
Diagnosis of obscure lesions of the skeleton. Evaluation of biopsy methods
Authors: D. C. Stahl
Journal: JAMA (1967)

A study was made of 85 patients with obscure lesions of the skeleton admitted to the Orthopedic Service of the Bronx Veterans Administration Hospital and the Hospital for Special Surgery. A wide spectrum of lesions were diagnosed, including malignant neoplasms in 66% of the patients. The relative merits and success rates of open and closed biopsy were compared. Although a higher percentage of satisfactory results was obtained with open biopsy (88%) than with closed biopsy (62%), the advantages associated with closed biopsy warrant its use in most instances.
Barium intravasation into portal venous system during barium enema examination
Authors: A. F. Salvo
Journal: JAMA (1976)

BARIUM enema examination has had a very low complication rate, approximately two in 10,000 studies. During a 20-year period at the Columbia Presbyterian Hospital (New York), Seaman and Wells<sup>1</sup>found only 13 examples of perforation of the colon during barium enema examination. We have recently encountered a unique complication of the barium enema, one that has been reported only once before, to our knowledge, ie, intravasation of barium into the portal venous system. This occurred during a barium enema examination of a patient with ulcerative colitis. <h3>Report of a Case</h3> A 36-year-old woman had had upper gastrointestinal bleeding, thought to be from a duodenal ulcer, in 1970 and 1972; both episodes were controlled medically. The patient had a history of chronic alcoholism. Approximately one month before admission, she experienced weakness, anorexia, and nausea, and passed several black stools. She had also lost 4.5 kg (10 lb) during this month.
Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials
Journal: BMJ (2011)

Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trialsThe authors have alerted us to some errors in this research paper by Rémy Boussageon and colleagues (BMJ 2011;343:d4169,
THE SCHOLAR AND THE STATE.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Changes in AIDS survival time in two San Francisco cohorts of homosexual men, 1983 to 1993
Authors: D. Osmond
Journal: JAMA (1994)

<h3>Background.</h3> —During the first decade since the recognition of the acquired immunodeficiency syndrome (AIDS), new therapies have been introduced and the frequency of clinical manifestations has changed. The impact of these changes on AIDS survival, however, has not been well characterized. <h3>Design.</h3> —A prospective cohort study of the outcomes of human immunodeficiency virus (HIV) infection. <h3>Setting.</h3> —Homosexual and bisexual men residing in San Francisco, Calif, recruited in 1983 and 1984 for two prospective studies and followed up for more than 9 years with clinical examinations. <h3>Participants.</h3> —A total of 761 HIV-positive homosexual and bisexual men. <h3>Main Outcome Measures.</h3> —Survival time from a CD4 lymphocyte count at 0.20×10<sup>9</sup>/L (200/μL and from a clinical AIDS diagnosis to death. <h3>Results.</h3> —Median survival time from a CD4 lymphocyte count at 0.20× 10<sup>9</sup>/L increased from 28.4 months in the October 1983 to November 1986 period to 40.1 months in the November 1986 to November 1988 period and is estimated at 38.1 months in the November 1988 to February 1993 period. Patients diagnosed with<i>Pneumocystis carinii</i>pneumonia (PCP) accounted for most of this increase with a gain in median survival time of 9.7 months (<i>P</i>=.0009), compared with a nonsignificant decline in the survival time of those patients without a PCP diagnosis. Multivariate analysis showed that rate of CD4 lymphocyte loss (<i>P</i>&lt;.001) and receipt of both PCP prophylaxis and antiretroviral therapy (<i>P</i>=.04) were significantly associated with longer survival time, whereas antiretroviral therapy alone was not (<i>P</i>=.81). Time to death from a clinical AIDS diagnosis was 14.7 months in the 1983 to 1986 period, 19.1 months in the 1986 to 1988 period, and an estimated 15.7 months in the 1988 to 1993 period. <h3>Conclusions.</h3> —Survival time from a CD4 lymphocyte count at 0.20×10<sup>9</sup>/L has improved significantly by about 1 year; yet survival time using the 1987 AIDS case definition has shown small improvement. The largest increase in survival time from a CD4 lymphocyte count at 0.20×10<sup>9</sup>/L was in patients diagnosed with PCP, suggesting that PCP prophylaxis and treatment were more important factors in longer survival time than antiretroviral therapy. (<i>JAMA</i>. 1994;271:1083-1087)
OPTIC NEURITIS
Authors: Nathaniel R. Katlan
Journal: JAMA (1953)

<h3>To the Editor:</h3> —The correspondence of Martin M. Fisher, M.D., inThe Journal, June 13, 1953, page 628, with reference to bilateral optic neuritis following enormous doses of chloramphenicol was carefully read by those who reported the case originally (Lasky, M. A.; Pincus, M. H., and Katlan, N. R.:<i>J. A. M. A.</i><b>151</b>:1401 [April 18] 1953). The references mentioned and numerous others were read by us previously. The reports in the literature concerning the ophthalmologic findings associated with bacterial endocarditis describe two types: bilateral papilledema (in which the vision remains normal for a long time) and embolic phenomenon (unilateral optic neuritis, with unilateral loss of vision). The case we reported was that of rapid bilateral loss of vision. The edema of the nerve heads was not that of papilledema as the loss of vision was extremely rapid and the edema was slight and nonprogressive. That the loss of