Highlighted research articles
Journal: Cancer Discovery (2023)

In This Issue| May 04 2023 Highlighted research articles Author & Article Information Online ISSN: 2159-8290 Print ISSN: 2159-8274 ©2023 American Association for Cancer Research2023American Association for Cancer Research Cancer Discov (2023) 13 (5): 1027–1029. https://doi.org/10.1158/2159-8290.CD-13-5-ITI Related Content This is a related article to: Integrative Pan-Cancer Genomic and Transcriptomic Analyses of Refractory Metastatic Cancer This is a related article to: Opportunities for Achieving the Cancer Moonshot Goal of a 50% Reduction in Cancer Mortality by 2047 This is a related article to: Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program View more This is a related article to: Abatacept/Ruxolitinib and Screening for Concomitant Respiratory Muscle Failure to Mitigate Fatality of Immune-Checkpoint Inhibitor Myocarditis This is a related article to: Targeted MDM2 Degradation Reveals a New Vulnerability for p53-Inactivated Triple-Negative Breast Cancer This is a related article to: Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death This is a related article to: Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell–Secreted Cytokines This is a related article to: Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma This is a related article to: Reprogramming Cancer into Antigen-Presenting Cells as a Novel Immunotherapy View less See also related Integrative Pan-Cancer Genomic and Transcriptomic Analyses of Refractory Metastatic Cancer Opportunities for Achieving the Cancer Moonshot Goal of a 50% Reduction in Cancer Mortality by 2047 Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program Abatacept/Ruxolitinib and Screening for Concomitant Respiratory Muscle Failure to Mitigate Fatality of Immune-Checkpoint Inhibitor Myocarditis Targeted MDM2 Degradation Reveals a New Vulnerability for p53-Inactivated Triple-Negative Breast Cancer Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell–Secreted Cytokines Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma Reprogramming Cancer into Antigen-Presenting Cells as a Novel Immunotherapy Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record May 4 2023 Citation Highlighted research articles. Cancer Discov 1 May 2023; 13 (5): 1027–1029. https://doi.org/10.1158/2159-8290.CD-13-5-ITI Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search In 2022, a new Cancer Moonshot goal was announced—to reduce U.S. age-standardized cancer mortality rates by 50% over 25 years. Shiels and colleagues estimated the trends in cancer mortality during 2000 to 2019 for all cancers and the six leading types and revealed that cancer death rates declined overall by 1.4%/year from 2000 to 2015 but accelerated to 2.3%/year during 2016 to 2019. This decline was driven, in part, by regressions in lung (−4.7%/year, 2014–2019), colorectal (−2.0%/year, 2010–2019), and breast (−1.2%/year, 2013–2019) cancer mortality. However, trends for pancreatic, prostate, and liver cancers were less promising. Opportunities to prevent, detect, and treat common cancers that could further reduce population-level cancer death rates are also discussed. See article, p. 1084. Immune checkpoint inhibitor (ICI)–associated myocarditis is a rare event that carries a high mortality rate. Salem and colleagues developed a strategy to identify individuals with severe myocarditis that included screening for/managing concomitant... You do not currently have access to this content.