tbuckley/cabot-search huggingface dataset:
OCCLUSION OF THE SWEAT PORE BY HYDEATION.
Authors: I. SARKANY, S. SHUSTER, MARIE C. STAMMERS
Journal: British Journal of Dermatology (1965)

Journal Article OCCLUSION OF THE SWEAT PORE BY HYDEATION. Get access I. SARKANY, I. SARKANY Department of Dermatology, Royal Free Hospital, Gray's Inn Road. London W.C.1 Search for other works by this author on: Oxford Academic Google Scholar S. SHUSTER, S. SHUSTER Department of Dermatology, Royal Victoria Infirmary, Newcastle‐upon‐Tyne Search for other works by this author on: Oxford Academic Google Scholar MARIE C. STAMMERS MARIE C. STAMMERS Institute of Dermatology, Homerton Grove, London, E.9 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 77, Issue 2, 1 February 1965, Pages 101–104, https://doi.org/10.1111/j.1365-2133.1965.tb14607.x Published: 01 February 1965
CONTACT DERMATITIS IX
Authors: Gun Agrup, Etain Cronin
Journal: British Journal of Dermatology (1970)

Journal Article CONTACT DERMATITIS IX Get access Gun Agrup, Gun Agrup Department of Dermatology, Lund, Sweden Search for other works by this author on: Oxford Academic Google Scholar Etain Cronin Etain Cronin Institute of Dermatology, St John's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 82, Issue 1, 1 January 1970, Pages 94–96, https://doi.org/10.1111/j.1365-2133.1970.tb02201.x Published: 01 January 1970
Atypical eumycetoma caused by<i>Phialophora parasitica</i>successfully treated with itraconazole and flucytosine
Authors: S.V. HOOD, C.B. MOORE, J.S. CHEESBROUGH, A. MENE, D.W. DENNING
Journal: British Journal of Dermatology (1997)

Phialophora species are occasional pathogens causing subcutaneous and invasive disease. We report the first case of eumycetoma caused by P. parasitica in an otherwise healthy U.K. resident who visited India. She failed to respond to surgical excision and itraconazole. 400 mg daily, but responded to itraconazole, 400 mg daily, and flucytosine, 1 g three times daily, lor 12 months. In vitro susceptibility testing predicted a response.
Distribution of anti-p80-coilin autoantibody in collagen diseaseand various skin diseases
Authors: M. FUJIMOTO, K. KIKUCHI, T. TAMAKI, N. YAZAWA, M. KUBO, H. IHN, S. SATO, Y. SOMA, K. TAMAKI
Journal: British Journal of Dermatology (1997)

Anti-p80-coilin antibody produces a unique pattern of immunofluorescence staining called nuclear dots characterized by the presence of up to six discrete nuclear bodis in interphase cell nuclei. The distribution of this antibody and its clinical relevance have not been established. We studied the prevalence of anti-p80-coilin antibody in the sera from 810 patients with collagen diseases and various skin diseases. Five sera showed the nuclear dot pattern by indirect immunofluorescence on an HEp-2 cell substrate, and reacted by immunoblotting with 80-kDa protein in a nuclear extract from HeLa cells. Four of these sera were from patients with localized scleroderma, and the other was from a patient with primary Raynaud's phenomenon. The patients with localized scleroderma who were positive for anti-p80-colin antibody had all been classified as having linear scleroderma. They had only one or two lesions, and were negative for antihistone and anti-single-stranded DNA antibodies. Our data indicate that anti-p80-colin antibody is uncommon in skin diseases: however, this antibody is present in patients with a milder form of liner scleroderma, although the incidence of positivity may not be high.
Subcorneal pustular dermatosis responsive to narrowband (TL-01) UVB phototherapy
Authors: D.I. Orton, S.A. George
Journal: British Journal of Dermatology (1997)

Journal Article Subcorneal pustular dermatosis responsive to narrowband (TL‐01) UVB phototherapy Get access D.I. Orton, D.I. Orton Photodermatology Unit. Amersham Hospital. Amersham. Buckinghamshire. HP7 OJD. U.K. Search for other works by this author on: Oxford Academic Google Scholar S.A. George S.A. George Photodermatology Unit. Amersham Hospital. Amersham. Buckinghamshire. HP7 OJD. U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 137, Issue 1, 1 July 1997, Pages 149–150, https://doi.org/10.1046/j.1365-2133.1997.d01-2079.x Published: 01 July 1997
Decreased β2-adrenergic receptor-mRNA and Ioricrin-mRNA, and increased involucrin-mRNA transcripts in psoriatic epidermis: analysis by reverse transcription-polymerase chain reaction
Authors: H. TAKAHASHI, M. KINOUCHI, T. TAMURA, H. IIZUKA
Journal: British Journal of Dermatology (1996)

Psoriatic hyperproliferative epidermis is characterized by a decreased β2‐adrenergic adenylate cyclase response as well us by altered differentiation markers that include decreased loricrin and increased involucrin, Using a quantitative reverse transcription‐polymerase chain reaction, we analysed the expression of β2‐adrenergic receptor‐mRNA. loricrin‐mRNA, and involucrin‐mRNA in the epidermis of five patients with psoriasis vulgaris. The mRNAs of the β2‐adrenergic receptor and loricrin in the involved epidermis were significantly decreased, by 0.35‐fold (P < 0.01) and 0.55‐fold (P < 0.05) respectively, compared with uninvolved epidermis. In contrast, the involucrin mRNA expression of the involved epidermis was significantly increased, by 3.77‐fold (P < 0.01). No significant difference in β‐actin mRNA transcripts was detected between the involved and the uninvolved epidermis. These results indicate that the altered expression of the β2‐adrenergic receptor, loricrin. and involucrin. in the psoriatic involved epidermis, is associated with different amounts of each mRNA transcripts.
Glutathione efflux associated with a low γ-glutamyl transpeptidase activity in human melanoma cells
Authors: M. BENATHAN
Journal: British Journal of Dermatology (1997)

The cellular concentration of reduced glutathione (GSH) modulates the sensitivity of human melanoma cells to alkylating drugs in vitro. To investigate whether the membrane‐associated enzyme γ‐glutamyl transpeptidase (γ‐GTP) involved in GSH breakdown was expressed in melanoma cells. the enzymatic activity of γ‐GTP as well as the secretion of GSH were measured in human melanoma cells from four different cell lines (Me8. JUSO, GLL19. Swift). All the cells showed low γ GTP activities (0–1 mU/mg protein) and released GSH in culture supernatants at significant rates. After incubation for 24 h in growth medium containing 0.1 mmol/L cystine, the levels of GSH in supernatants ranged from 56 to 111 nmol GSH/mg protein. The GSH metabolism of melanoma cells was also evaluated by measuring the levels of the melanogenesis intermediate 5‐S‐cysteinyldopa under different experimental conditions. The results of these experiments suggest that melanoma cells have a low ability to metabolize the tripeptide GSH. which appears to be responsible for GSH secretion and accumulation in culture supernatants.
Erythema elevatum diutinum in association with coetiac disease
Authors: K. TASANEN, R. RAUDASOJA, M. KALLIOINEN, A. RANKI
Journal: British Journal of Dermatology (1997)

Erythema elevatum diutinum (EED) has been described in association with several immunological or infectious diseases. We describe a female patient who presented with clinically and histologically typical EED in whom previously undiagnosed coetiac disease was found. Appearance of EED lesions was preceded by widespread joint pains. In extensive laboratory tests, the only abnormal findings were an elevated erythrocyte sedimentation rate (ESR) and decreased haemoglobin and folic acid levels. Later. IgA and IgG type antireticulin and antigliadin antibodies were detected. Serum total IgA was elevated but no paraproteinaemia was found. In lesional skin, granular deposits of IgA and C3 were seen at the dermo-epidermal junction. A duodenal biopsy revealed total villous atrophy. Dapsone treatment was partly effective but complete healing of the EED lesions was achieved only after the introduction of a strict gluten-free diet. The patient has now remained symptom-free on the diet for 1.5 years.
Ethanol enhances the IFN-γ, TGF-α and IL-6 secretion in psoriatic co-cultures
Authors: H.M. OCKENFELS, C. KEIM-MAAS, R. FUNK, G. NUßBAUM, M. GOOS
Journal: British Journal of Dermatology (1996)

Summary Evidence suggests an association between alcohol consumption and psoriasis. This relationship is still undefined, although long-term alcohol intake influences the immune system. Interactions between T cells and keratinocytes are important for the pathogenesis of psoriasis, by secretion of proinflammatory cytokines and growth factors in psoriatic skin. IL-2, IL-6, IL-8, IFN-γ and TGF-α are hallmark cytokines in a psoriatic cytokine network. We investigated whether ethanol influences the secretion of these cytokines using a co-culture model with keratinocytes from psoriatic patients (n = 9) or from healthy controls (n = 9), with HUT 78 lymphocytes, and determined the cytokine levels with or without ethanol treatment in the culture supernatants. TGF-α and IFN-γ levels were elevated in the ethanol-treated psoriatic co-cultures, to 150% and 175% respectively, but neither in co-cultures with keratinocytes derived from healthy control individuals nor in monocultures. Treatment with ethanol elevated slightly the IL-6 levels in the monocultures from psoriatic and control keratinocytes to 125% but not in HUT 78 monocultures. In the psoriatic co-cultures, IL-6 levels were elevated in the culture supernatants to almost 160%, but they were not influenced by ethanol in co-cultures with control keratinocytes. The cytokine levels of IL-8 or IL-2 were not significantly influenced in the psoriatic mono- and co-cultures or in HUT 78 cultures. If ethanol influences the cytokine secretion of psoriatic keratinocytes and HUT 78 lymphocytes in co-culture conditions, these data suggest that ethanol could also influence the psoriatic cytokine network in vivo, which may explain the aggravation of this disease in alcohol-consuming psoriatic patients.
Multiple basal cell carcinomas: no association with <i>HLA-DRB, HLA-DQAI</i> or <i>HLA-DQBI</i> in Swedish patients
Authors: L. EMTESTAM, P. WALLBERG, A. ALDENER, O. OLERUP
Journal: British Journal of Dermatology (1996)

Journal Article Multiple basal cell carcinomas: no association with HLA‐DRB, HLA‐DQAI or HLA‐DQBI in Swedish patients Get access L. EMTESTAM, L. EMTESTAM Department of Dermatology, Huddinge Hospital, S‐141 86 Huddinge, Sweden L.Emtestam. Search for other works by this author on: Oxford Academic Google Scholar P. WALLBERG, P. WALLBERG Department of Dermatology, South Hospital, Stockholm, Sweden Search for other works by this author on: Oxford Academic Google Scholar A. ALDENER, A. ALDENER Center for BioTechnology, Karolinska Institute, NOVUM, Huddinge and Department of Clinical Immunology. Huddinge Hospital, Huddinge, Sweden Search for other works by this author on: Oxford Academic Google Scholar O. OLERUP O. OLERUP Center for BioTechnology, Karolinska Institute, NOVUM, Huddinge and Department of Clinical Immunology. Huddinge Hospital, Huddinge, Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 134, Issue 5, 1 May 1996, Pages 886–891, https://doi.org/10.1046/j.1365-2133.1996.122857.x Published: 01 May 1996 Article history Accepted: 01 September 1995 Published: 01 May 1996
A patient with plaque-stage mycosis fungoides has successfully been treated with long-term administration of IFN-γ and has been in complete remission for more than 6 years
Authors: T. HORIKOSHI, H. ONODERA, H. EGUCHI, N. HANADA, K. FUKUZAWA, M. TAKAHASHI, K. ISHIHARA, S. IKEDA
Journal: British Journal of Dermatology (1996)

We report the successful treatment of a patient with plaque‐stage mycosis fungoides with long‐term and intravenous administration of recombinant human interferon‐γ (IFN‐γ) and discuss the possible mechanisms of this therapy. A 55‐year‐old female patient had been resistant to existing treatments and had suffered repeated exacerbations over a 5‐year period. Four weeks after initiation of 2 × 106U/day of IFN‐γ. a > 10% decrease in the affected surface area was noted. Twenty‐two weeks after the administration of 228 × 106U of IFN‐γ, complete remission (CR) was obtained. The CR continued for 13 weeks, but this was followed by an exacerbation. The second CR was obtained after the IFN‐γ dosage was increased to 16 × 106U/week. The dosage was then gradually reduced by 2–4 × 106U every 2 or 3 months. She was treated with a total dose of 2814 × 106 of IFN‐γ. She has been followed up for more than 6 years, and there has been no recurrence of mycotic skin lesions nor any visceral involvement. During therapy, no serious side‐effects were noted. Long‐term administration of IFN‐γ is useful for the treatment of patients with intractable mycosis fungoides. A gradual decrease in the dose of IFN‐γ is important for maintaining remission.
Safety and efficacy of calcipotriol ointment (Dovonex®) in treating children with psoriasis vulgaris
Authors: C.R. DARLEY, W.J. CUNLIFFE, C.M. GREEN, P.E. HUTCHINSON, M.R. KLABER, N. DOWNES
Journal: British Journal of Dermatology (1996)

Calcipotriol (Dovonex) ointment has been shown to be an effective, well tolerated, and acceptable treatment for psoriasis vulgaris in adults. This open study was conducted in 16 U.K. centres to assess the safety and efficacy of calcipotriol ointment in treating psoriasis vulgaris in children. Following a 2-week washout, patients were treated with calcipotriol ointment, 50 μg/g twice daily, for up to 8 weeks. A blood sample was taken on entry and a second'on treatment' sample was taken after either 2 or 8 weeks treatment. Sixty-six children (26 boys, 40 girls, age range from 3 to 14 years) entered and 58 completed the study. There was a statistically significant reduction in the mean (±SD) Psoriasis Area and Severity Index (PASI) from 6.1 ± 3.5 at the start of treatment to 2.7 ± 1.9 at the end of treatment (P < 0.001). Marked improvement or clearance of psoriasis at the end of treatment occurred in 65% of patients as assessed by the investigator and 62% as assessed by the patient. Cosmetic acceptability of calcipotriol ointment was found to be good or excellent in 79% of patients. Eight patients withdrew from the study (four defaulted, two unacceptable responses, two adverse events). Adverse events were reported by 16 patients; the most common being local irritation (seven patients). There was no significant change in the mean serum ionized calcium from baseline to 2 or 8weeks treatment. Similarly, there were no consistent or clinically important changes in haematological, or other biochemical parameters, measured during the study period. Calcipotriol ointment has been shown to be an effective, well tolerated, and acceptable treatment for psoriasis vulgaris in children.
Role of protin kinases in the<i>in vitro</i>differentiation of human epidermal HaCaT cells
Authors: J.M. PARAMIO, J.L. JORCANO
Journal: British Journal of Dermatology (1997)

Different chemicals that specifically and selectively inhibit or activate protein kinases have been used to define the possible roles of these enzymes in the different steps of epidermal differentiation. Using HaCaT keratinocytes as a model, and under conditions in which cell proliferation is minimally affected, we found that tyrosine kinase inhibition leads to an inhibition of early (spinous: keratin K 10 expression) and late (granulosum: involucrin expression) differentiation processes, cGMP- and cAMP-dependent protein kinases appear to modulate the transition form spinous to granular differentiation, a process which seems to be negatively controlled by protein phosphatases. Finally, enzymes belonging to the protein kinase C family appear to facilitate the transition from spinous to granular differentiation programmes while inhibiting the early steps of epidermal differentiation.
Multiple squamous cell carcinomas in a psoriatic patient following high-dose photochemotherapy and cyclosporin treatment: response to long-term acitretin maintenance
Authors: P.C.M. VAN DE KERKHOF, M.J.M. DE ROOIJ
Journal: British Journal of Dermatology (1997)

Journal Article Multiple squamous cell carcinomas in a psoriatic patient following high–dose photochemotherapy and cyclosporin treatment: response to long–term acitretin maintenance Get access P.C.M. VAN DE KERKHOF, P.C.M. VAN DE KERKHOF Department of Dermatology, University Hospital Nijmegen, PO Box 9101, 6500 HB Nijmegen, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar M.J.M. DE ROOIJ M.J.M. DE ROOIJ Department of Dermatology, University Hospital Nijmegen, PO Box 9101, 6500 HB Nijmegen, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 136, Issue 2, 1 February 1997, Pages 275–278, https://doi.org/10.1046/j.1365-2133.1997.d01-1187.x Published: 01 February 1997 Article history Accepted: 08 July 1996 Published: 01 February 1997
Expression of tetra-spans transmembrane family (CD9, CD37, CD53, CD63, CD81 and CD82) in normal and neoplastic human keratinocytes: an association of CD9 with α3β1 integrin
Authors: H. OKOCHI, M. KATO, K. NASHIRO, O. YOSHIE, K. MIYAZONO, M. FURUE
Journal: British Journal of Dermatology (1997)

Tetra‐spans transmembrane family (TSTF) members (CD9, CD37, CD53, CD63, CD81 and CD82) have potent effects on cell growth, motility and adhesion in various cells. However, little is known about their expression in human skin. Using immunohistological techniques, we have studied the localization of all six members of TSTF in normal and carcinomatous human keratinocytes. CD9, CD81 and CD82 were expressed in the entire living layers of the epidermis. Their staining pattern was quite similar, and was mainly intercellular with occasional intracellular immunoreactivity. CD53 expression was confined to the intercellular spaces of the upper spinous or granular layer in the normal epidermis. No clear‐cut expression of CD63 could be detected in the epidermis. CD37 was not detected at all. Cultured human keratinocytes also expressed CD9, CD81 and CD82 at the surface membrane of cell‐cell boundaries. Expression of CD37 and CD53 was negative in cultured keratinocyte, while CD63 was clearly localized in the cytoplasmic lysosomes. An immunoprecipitation assay revealed that α3β1 integrin is molecularly associated with CD9. The expression of CD9, CD81 and CD82 was markedly down‐regulated in basal cell carcinoma but not in Bowen's disease. The abundant and differential expression of TSTF molecules and the selective association of CD9 with α3β1 integrin suggest that the TSTF molecules may be involved in the regulation of epidermal differentiation and integrity in vivo.
Transforming growht factor β1 and its latent form binding protein-1 associate with elastic fibres in human dermis: accumulation in actinic damage and absence in anetoderma
Authors: T. KARONEN, L. JESKANEN, J. KESKI-OJA
Journal: British Journal of Dermatology (1997)

Latent transforming growth factor-β1 (TGF-β1) and its binding protein-1 (LTBP-1) are components of the extracellular matrix microfibrils of cultured human fibroblasts. Using immunohistochemistry we have studied the localization of TGF-β1 and LTBP-1 and compred their distribution iwth that of elastic fibres in the interstitial connective tissue matrix of the human dermis. Prominent LTBP-1 specific fibrillar staining co-localized with the elastic fibres in normal human skin. Co-distribution was also observed in a number of pathological states of the elastic fibres such as solar elastosis, solar keratosis and pseudoxanthoma elasticum. TGF-β1 had a staining pattern similar to that of LTBP-1 in solar elastosis and solar kertosis. No staining for LTBP-1 or TGF-β1 was found in dermis devoid of elastic fibres, as in anetoderma. LTBP-1 is released from the extracellular matrix of cultured human fibroblasts, epithelial and endothelial cells by proteases. Analyogously, the immunoreactivity for LTBP-1 and TGF-β1 were also lost form the skin sections by elastase, and by trypsin, a protease pretreatment commonly used in immunohistochemistry. These results indicate that LTBP-1 is a component of the elastin-associated microfibrils of the interstitial connective tissue matrix of human skin. Furthermore, the small latent form of TGF-β1 is likely to associate with the extracellular matrix of human dermis via LTBP-1. The release of latent TGF-β1 from the matrix, as a consequence of proteolytic cleavage of LTBP-1, is a plausible extracellular mechanism for the regulation of TGF-β1 activation.
Cat-Bite Tularemia
Authors: Ronald W. Quenzer
Journal: JAMA (1977)

TULAREMIA is remarkable for its diverse modes of transmission and variable forms of presentation in humans. Although rabbits and ticks have been the main sources for sporadic cases of human tularemia throughout the United States, more than 100 different animals may transmit the disease. This case is of interest because of the unusual source of the infection. <h3>Report of a Case</h3> On Sept 23, 1976, a 33-year-old surveyor was bitten on the right hand by an 8-week-old domestic kitten that had been raised on his ranch in southwestern Colorado. Four days later, he was admitted to a hospital in Durango, Colo, because of fever, chills, swelling of his right hand, and pain in his right axilla. He had an oral temperature of 38.5 °C, a clean ulcerated wound near the metacarpophalangeal joint of the right index finger, and a tender, enlarged, right axillary lymph node. A WBC count was 9,500/cu
Rheumatic Fever Following Streptococcal Vaccination
Authors: Benedict F. Massell
Journal: JAMA (1969)

Twenty-one healthy siblings of patients with rheumatic fever were vaccinated with a type 3 streptococcal M protein. During and following vaccination these children experienced 18 group-A streptococcal infections (none type 3) with a rise in antistreptolysin O titer. Two infections were followed by definite rheumatic fever and one by probable rheumatic fever. This high rate contrasts with the observation of five cases of rheumatic fever in 447 similar streptococcal infections in nonvaccinated siblings. This experience necessitates giving consideration to the possibility that streptococcal vaccination of children may alter their tissue response to subsequent streptococcal infection. Most importantly, this experience indicates the need for extreme caution in the use of streptococcal Vaccines in human subjects.
Re: Role of the Oxidative DNA Damage Repair Gene OGG1 in Colorectal Tumorigenesis
Authors: Ben Kinnersley, Stephan Buch, Sergi Castellví-Bel, Susan Mary Farrington, Asta Forsti, Jochen Hampe, Kari Hemminki, Robert M. W. Hofstra, Emma Northwood, Claire Palles, Manuela Pinheiro, Clara Ruiz-Ponte, Clemens Schafmayer, Manuel R. Teixeira, Helga Westers, Tom van Wezel, D. Timothy Bishop, Ian Tomlinson, Malcolm G. Dunlop, Richard S. Houlston
Journal: JNCI Journal of the National Cancer Institute (2014)