tbuckley/cabot-search huggingface dataset:
Infants at Risk of HCV Infection
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ultrasonic Imaging of the Abdomen
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association of baseline modified Glasgow Prognostic Score (mGPS) with survival outcomes in patients with metastatic urothelial cell carcinoma (mUCC) treated with immune checkpoint inhibitors (CPI).
Authors: Jacqueline T Brown, Yuan Liu, Julie M. Shabto, Dylan J. Martini, Deepak Ravindranathan, Elise Hitron, Greta Russler, Sarah Caulfield, Lauren Beth Yantorni, Shreyas S. Joshi, Haydn Kissick, Kenneth Ogan, Wayne Harris, Bradley Curtis Carthon, Omer Kucuk, Viraj A. Master, Mehmet Asim Bilen
Journal: Journal of Clinical Oncology (2020)

563 Background: The mGPS, a clinical tool that incorporates albumin and C-reactive protein, has proven useful in the prognostication of multiple cancers. Several CPI agents have been approved for the treatment of mUCC but a prognostic biomarker is needed. We investigated the impact of mGPS on survival outcomes in mUCC patients receiving CPI. Methods: We retrospectively reviewed mUCC patients treated with CPI (PD-1 or PD-L1 inhibitors) at Winship Cancer Institute from 2015 to 2018. Overall survival (OS) and progression-free survival (PFS) were measured from the start date of CPI until death or clinical/radiographic progression, respectively. mGPS was defined as a summary score with one point given for CRP &gt; 10 mg/L and/or albumin &lt; 3.5 g/dL. Univariate (UVA) and multivariate (MVA) analyses were carried out using Cox proportional hazard model for OS and PFS. Results: A total of 53 patients were included with a median follow up 27.1 months. The median age was 70 years with 84.9% male and 20.8% black. Baseline mGPS was 0 in 43.4%, 1 in 28.3% and 2 in 28.3%. The correlation between mGPS and other inflammatory biomarkers, such as the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR) and platelet-to-lymphocyte ratio (PLR), was high with Pearson correlation coefficients ≥ 0.48 (p ≤ 0.0003). Increased mGPS at the time of CPI initiation was associated with poorer OS and PFS (Table). Conclusions: The mGPS may be a useful prognostic tool in mUCC patients when treatment with CPI is under consideration. These results warrant a larger study for validation.[Table: see text]
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1958)

COMMITTEE ON MATERNAL WELFAREDefect of Interventricular Septum, with Pulmonary Edema and CongestionA twenty-one-year-old primipara with known congenital heart disease died suddenly on the day of discharge after an uneventful labor and delivery.The patient's activities had been restricted since childhood, and some clubbing of the fingers, with mild cyanosis, had developed, but there was no history of decompensation. She was advised not to marry. However, she married and soon became pregnant, first reporting to an obstetrician at fifteen weeks. She was seen at frequent intervals in a prenatal course that was satisfactory until admission at twenty-five weeks for . . .
Abstract 1567: Race, RNA-based recurrence scores, and survival of early hormone receptor-positive breast cancer: A population-based study
Authors: Yunan Han, Graham A. Colditz, Ying Liu
Journal: Cancer Research (2019)

Abstract Introduction: Compared with white women, black American women are less likely to develop hormone receptor-positive breast cancer, but experience higher mortality of the disease. The 21-gene recurrence scores (RS) predict individualized benefit of chemotherapy for early hormone receptor-positive breast cancer. We hypothesize that the RS scores in early hormone receptor-positive breast cancer are higher in black women than in white women and this contributes to the worse outcomes among black women with hormone receptor-positive breast cancer. Methods: Utilizing the Surveillance, Epidemiology, and End Results database, we identified 75,861 women (75.7% non-Hispanic white, 7.9% non-Hispanic black, 8.0% Asian/Pacific Islander, and 8.5% Hispanic) with stage I-III hormone receptor-positive breast cancer diagnosed between 2004 and 2014. RS scores were categorized into low, medium, and high groups using traditional cutoffs (18 and 30) and the cutoffs used in the TAILORx clinical trial (11 and 25). We performed multivariable logistic regression to evaluate odds ratios (ORs) of RS categories, and Cox proportional hazard regression to estimate hazard ratios (HRs) for breast cancer-specific mortality and overall mortality. Results: The multivariable adjusted least square mean of RS was significantly higher in black (23.2) than other racial/ethnic groups (white 22.9, Asian/PI 22.5, Hispanic 22.4; p&amp;lt;0.0001). Compared with white women, black women were more frequently in the high RS category defined by a cutoff of 30 (case-only OR=1.24, 95% CI: 1.11-1.39), Asian/PI (OR=0.88, 95% CI: 0.79-0.98) and Hispanic (OR=0.80, 95% CI: 0.72-0.89) were less frequently in the high RS category defined by a cutoff of 25. Compared with white women, the HR of breast cancer-specific mortality was 1.37 (95% CI: 1.10-1.69) in black women, and 0.65 (95% CI: 0.48-0.90) in Asian/PI women, after adjustment for demographic factors, RS categories and other tumor characteristics, and treatment. This association did not significantly vary by RS categories. The multivariable-adjusted associations between race/ethnicity and overall mortality were similar to those for breast cancer-specific mortality. Conclusions: Racial/ethnic differences in early hormone receptor-positive breast cancer outcomes could not be explained by RS scores. Potential differences in tumor biology that are not related to the genes in the 21-gene assay may contribute to the worse prognosis of black women with hormone receptor-positive breast cancer. Citation Format: Yunan Han, Graham A. Colditz, Ying Liu. Race, RNA-based recurrence scores, and survival of early hormone receptor-positive breast cancer: A population-based study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1567.
CYSTICERCOSIS CEREBRI
Authors: N. Candreviotis
Journal: JAMA (1960)

<h3>To the Editor:—</h3> InThe Journal, April 30, page 2036, in the article, "Cysticercosis Cerebri," Drs. R. B. Haining and R. G. Haining report the case of a 45-year-old man. The clinical diagnosis of brain tumor was made, but at operation (craniotomy) a free-floating cyst in the fourth ventricle of the brain was found, in which a cysticercus cellulosae was identified. Last year, I observed a case of multiple disseminated cerebral cysticercosis in a postmortem examination at the Hospital "Evangelismos." This case shows similarities to one of the cases reported by White and others quoted in the article inThe Journal. The patient, a 55-year-old man, was admitted to the Hospital "Evangelismos" on June 1, 1959, having had for 10 years a history of repeated epileptic seizures characterized by clonic spasms and loss of consciousness. Physical examination revealed a light muscular hypertonia on both sides, a positive Babinski sign on
Increased Prevalence of Psychopathology and Maladaptive Personality Traits after Long-Term Cure of Cushing’s Disease
Authors: Jitske Tiemensma, Nienke R. Biermasz, Huub A. M. Middelkoop, Roos C. van der Mast, Johannes A. Romijn, Alberto M. Pereira
Journal: Endocrine Reviews (2010)

Context and Objective:Psychopathology and maladaptive personality traits are often observed during the active phase of Cushing’s disease (CD). We hypothesized that patients with long-term cure of CD show persistent psychopathology and maladaptive personality traits.
Editorial Board
Authors: Donald Leung, Stanley Szefler, Colo Associate, Andrea Apter, Pedro Philadelphia, Bruce Avila, Baltimore Bochner, Joshua Boyce, Robert Bush, Fred Finkelman, Dennis Ledford, Tampa Fla, Deborah Meyers, Luigi Notarangelo, David Peden, Harald Renz, Marburg Germany, Marc Rothenberg, William Shearer, Scott Sicherer, New York, Donata Vercelli, Erika Von Mutius, Germany Munich, Vernon Statistics Editor, Hershey Chinchilli, John Atkinson, St Louis, A Burks, Mitchell Grayson, Milwaukee Wis, Simon Hogan, Hirohisa Saito, Talal Chatila, Los Angeles, Elizabeth Matsui, Thomas Platts-Mills, Gordon Bloomberg, Larry Borish, Angela Haczku, Jordan Orange, Darryl Zeldin, Leonard Bacharier, Sten Dreborg
Journal: Journal of Allergy and Clinical Immunology (2012)
Osimertinib vs comparator EGFR-TKI as first-line treatment for EGFRm advanced NSCLC (FLAURA): Final overall survival analysis
Authors: B.C. Cho, Y. Ohe, C. Zhou, T. Reungwetwattana, Y. Cheng, B. Chewaskulyong, K.H. Lee, D. Planchard, J.F. Vansteenkiste, J.E. Gray, R. Shah, P.K. Cheema, M. Tiseo, T. John, R. Hodge, Y. Rukazenkov, J.-C. Soria, M.-C. Lin, F. Imamura, S.S. Ramalingam
Journal: Annals of Oncology (2019)
Therapeutic targeting of casein kinase 1δ in breast cancer
Authors: Laura H. Rosenberg, Marie Lafitte, Victor Quereda, Wayne Grant, Weimin Chen, Mathieu Bibian, Yoshihiko Noguchi, Mohammad Fallahi, Chunying Yang, Jenny C. Chang, William R. Roush, John L. Cleveland, Derek R. Duckett
Journal: Science Translational Medicine (2015)

Casein kinase 1δ promotes breast tumorigenesis by activation of β-catenin and can be targeted in some breast cancers.
The association of baseline anxiety and depression with overall survival (OS) in colorectal cancer (CRC).
Authors: Pierre Y. Cheung, Tian Yang Darren Liu, Jason D. Kim, Winson Y. Cheung
Journal: Journal of Clinical Oncology (2014)

e20554 Background: Patient-reported measures such as psychosocial wellbeing and quality of life have been reported to correlate with cancer survival, but the specific factors within these constructs that associate with outcomes remains poorly defined. Our aim was to examine the effect of baseline anxiety and depression on OS in a population-based cohort of CRC patients. Methods: Patients diagnosed with CRC in 2008, referred to any 1 of 5 regional cancer centers in British Columbia, and who completed a baseline questionnaire to evaluate anxiety and depression were reviewed. We developed a scoring system based on these patient-reported survey data to characterize intensity and subsequently categorized patients as having no, mild, moderate or severe anxiety and/or depression. Vital statistics were captured by medical records. Unadjusted Kaplan-Meier methods and multivariate Cox regression models that controlled for additional socio-demographic and clinical characteristics were constructed to correlate anxiety and depression with OS. Results: A total of 449 patients were included: median age was 66 years (range 26-92), 52% were men, and 69% were White. A significant proportion of respondents reported anxiety (58%) or depression (45%) at baseline. Among them, the majority indicated their anxiety and depressive symptoms were severe (43% and 43%, respectively). Women and those who were single or unmarried were more likely to have anxiety and depression (p<0.001 and p=0.02, respectively). In unadjusted analyses, we observed a trend where increased severity of anxiety (p=0.07) and depression (p=0.04) correlated with worse outcomes. In Cox regression that considered other prognostic factors, however, this observation failed to persist, and neither anxiety nor depression associated with OS (Table). Conclusions: The impact of psychosocial wellbeing and quality of life on CRC outcomes that have been previously described in the literature are unlikely to be mediated through baseline anxiety or depression. Anxiety HR for death P-value Depression HR for death P-value None 1.0 — None 1.0 — Mild 1.11 0.77 Mild 0.71 0.31 Moderate 1.29 0.37 Moderate 1.10 0.18 Severe 1.37 0.28 Severe 0.74 0.32
DIPHTHERIA BACILLI IN THE THROATS OF HEALTHY CHILDREN.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"SLEEP APNOEA IN HEART FAILURE". R. SCHULZ, A. BLAU, J. BORGEL, H.W. DUCHNA, I. FIETZE, I. KOPER, R. PRENZEL, S. SCHADLICH, J. SCHMITT, S. TASCI AND S. ANDREAS FOR THE WORKING GROUP "KREISLAUF UND SCHLAF" OF THE GERMAN SLEEP SOCIETY (DGSM). EUR RESPIR J 2007; 29: 1201 1205.
Journal: European Respiratory Journal (2007)
十二烷基硫酸钠诱导刺激的解剖部位差异:随机对照试验
Authors: D. Leskur, J. Bukić, A. Petrić, L. Zekan, D. Rušić, A. Šešelja Perišin, I. Petrić, M. Stipić, N. Puizina‐Ivić, D. Modun
Journal: British Journal of Dermatology (2019)

月桂酸钠 (SLS) 是一种化学物质,被用于诱导皮肤刺激,模拟刺激性接触性皮炎 (ICD)。ICD 是一种由于直接接触某些物质而导致皮疹、发红、起泡、瘙痒、干燥和皮肤开裂的疾病。这是一种常见的职业病,在英国所有的皮肤科会诊中占 4‐7%。这种由 SLS 诱导的刺激通常用于测试可用于缓解 ICD 症状的不同治疗方法的有效性。刺激通常是在前臂上诱导,但也已经发现被用于其他位置,例如上背部。不同解剖部位的刺激程度可能不同。这些差异可能会影响治疗检测的结果。这意味着治疗在一个位置取得的有益效果可能不会在另一个位置取得。这项来自克罗地亚的研究旨在研究皮肤对刺激反应的变化及其对 SLS 诱导的 ICD 治疗的影响。刺激物被涂在健康志愿者的前臂和上背部。选择润肤(保湿)霜作为治疗手段。其中一只前臂和背部一侧接受了为期九天的润肤霜治疗,而另一些则没有接受治疗。用皮肤探针测量皮肤刺激程度和恢复情况。研究人员发现,与前臂相比,上背部对刺激物的反应更强烈,皮肤恢复得更快。此外,所测试的润肤乳霜并没有改善皮肤的恢复。综上所述,解剖位置是影响用于测试治疗效果的研究结果的重要因素。未来的研究应该始终准确地报告测试位置。在不同的解剖位置使用这种刺激模型的研究产生的结果不一定能够直接可比。
SAT0366 Comparing The Characteristics of Adult and Pediatric Patients with Polyarteritis Nodosa: Table 1.
Authors: A. Erden, E.D. Batu, E. Bilgin, H.E. Sonmez, B. Armagan, A. Sari, Z.S. Arici, U. Kalyoncu, Y. Bilginer, S.A. Bilgen, O. Karadag, I. Ertenli, S. Ozen, S. Kiraz
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Polyarteritis nodosa (PAN) as a necrotizing vasculitis of medium or small arteries without glomerulonephritis or vasculitis in arterioles, venules or capillaries and not associated with antineutrophil cytoplasmic antibodies. It is more common in middle-aged adults when compared with children. <h3>Objectives</h3> The aim of this study was to examine and compare the clinical characteristics of adult and pediatric patients with PAN. <h3>Methods</h3> Nine pediatric (&lt;18 years of age) and 28 adult patients with a clinical diagnosis of PAN who were seen at the Departments of Rheumatology and Pediatric Rheumatology, Hacettepe University, Ankara, Turkey were included in the study group. The pediatric and adult patients were classified as PAN according to the Ankara 2008 and ACR 1990 criteria, respectively. The clinical features and response to therapy were evaluated retrospectively. <h3>Results</h3> The characteristics of PAN patients were summarized in Table 1. According to the results with a statistical significance, neurologic involvement was more common and the duration of induction treatment was longer in adults (p=0.008 and p&lt;0.001, respectively). Renal involvement was more common in adults than children, however this difference did not reach statistical significance. 4/28 (14.2%) adult and 3/9 (33.3%) pediatric patients had accompanying familial Mediterranean fever. Of adult patients, 85% (n=23) had received cyclophosphamide plus corticosteroid for induction treatment while three pediatric patients received CYC and four received mycophenolate mofetil addition to corticosteroid treatment. <h3>Conclusions</h3> Although our study population is limited, neurologic and renal involvement were more common and the duration of induction treatment was longer in adults patients with PAN. There is no previous study comparing the characteristics of pediatric and adult patients with PAN Multicenter collaboration remains essential to determine the characteristic features of PAN in patients of different age groups. <h3>References</h3> Lightfoot RW Jr, Michel BA, Bloch DA, et al. The American College of Rheumatology 1990 criteria for the classification of polyarteritis nodosa. Arthritis Rheum 1990;33:1088–1093 <h3>Disclosure of Interest</h3> None declared
Correction: Guidelines for the management of asthma: A summary
Journal: BMJ (1993)

progression.Nevertheless, a randomised controlled trial of high dose prednisolone (up to 60 mg per day according to age and weight) in 143 patients with active constrictive pericaditis in South Africa suggested that patients treated with steroids have a greater resolution of their symptoms (exercise capacity) and signs (pulse rate and height of jugular venous pulse) during treatment.10This effect was not completely sustained once the treatment was stopped.In addition fewer patients progressed to pericardectomy (21% v 30%) or death (4% v 11%) in the steroid treated group.One fifth of patients will require pericardectomy once they constrict regardless ofthe treatment they receive.Pericardectomy is now a safe procedure with a 97% survival rate if performed early in a patient with good left ventricular function.'IIt is generally recommended that the pericardium is removed from the anterolateral and diaphragmatic aspects of the left ventricle extend- ing to the atrioventricular sulci and subsequently removed from the anterior and inferior surfaces of the right ventricle, especially around the inflow tracts. DiscussionGJD: Tuberculous pericarditis remains an un- common disease in the United Kingdom and normally presents late in the effusive stage.The striking feature of this case is the rapidity with which classic tamponade progressed to classic constriction.The South African study included only patients who had already developed constrictive physiology, and there is no evidence that steroids prevent the development of constriction.Once constriction has developed early pericardectomy -has a better prognosis than delaying the operation and therefore giving steroids at this stage is probably not beneficial.ss: The usefulness of adjunctive steroid therapy in tuberculous infection has been shown for only pericardial effusion and meningitis.This patient did not receive steroids.Tuberculosis is commonly associated with HIV infection, especially in patients from sub- Saharan Africa.Js: This case highlights the current lack of under- standing of mechanisms by which acute inflammation may become persistent and lead to scarring with loss or serious derangement of organ function.Apparently successful treatment, with a fall in markers of acute inflammation, failed to prevent postinflammatory scarring.This is commonly seen in inflammatory disease of other organs, including the lidney, where
Chemical models important in understanding the ways in which chromate can damage DNA.
Authors: P O'Brien, A Kortenkamp
Journal: Environmental Health Perspectives (1994)

Chromate is an established human carcinogen. There have been many studies of the reactivity of chromate aimed at improving understanding of chromate toxicity. In the present paper a number of conclusions of these studies are reviewed and considered in the light of new results obtained in our laboratories. A number of hypotheses are considered; it is concluded, however, that it is impossible to reconcile the generation of strand breaks by chromate during its reduction by glutathione with any simple mechanism involving the generation of DNA lesions by free hydroxyl radicals. Kinetic, spin-trapping, and competition kinetic studies, based on a strand-breaking assay, are reported in support of this conclusion.
The Geographic Pathology of Children's Lymphomas
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal