tbuckley/cabot-search huggingface dataset:
Topical retinoic acid changes the epidermal cell surface glycosylation pattern towards that of a mucosal epithelium
Authors: C. E. M. GRIFFITHS, E. DABELSTEEN, J. J. VOORHEES
Journal: British Journal of Dermatology (1996)

Topical all-trims retinoic acid (RA) produces a nutnber ol epidermal changes which are indistinguishable l'rom those observed following treatment with a local irritant, namely sodium lauryl sulphate (SI.S).Thisdhserviition has led to criticism thai the efficacy of RA in disorders such as photoageing.Is merely a result of irrilancy.In stratitied epithelia.the cellular difterentiation process is characterized by a stepwise synthesis of cell surface carhohydrates.and each type of stratitied epithelium has its own specific pattern of carbohydrate expression.Glycosyltrimsferases. which are responsible for carbohydrate synthesis, are influenced by retinoids.Thus, we investigated whether epidermal cell surface glycosylation is altered in skin treated with topical RA, and contrasted it wilh changes induced by topical SLS.Skin biopsies were obtained from seven normal volunteers who had been treated, on three separate areas of buttock skin, with single applications of 0 1% RA. 2% SLS, or vehicle creatiis, followed by 4-day occlusion.Biopsies were assessed imniunohistologically using highly specific monoclonal antibodies lo cell surface carbohydrates (types 1, 2 and 3 chain structures), previously demonstrated in the epidermis and iti oral mucosal epithelium.Although type 1 chain structures were not demonstrated in any of the samples, the distribution of type 2 and 3 chain structures in RAtreated epidermis was altered towards that seen in a mucosal epithelium.T antigen, a mucin-type cell surface carbohydrate structure normally expressed throughout the epidermis, was only observed in the granular layer of RA-treated epidermis-a feature of mucosal epitheiia.Le^, normally only seen in non-keratinized buccal epithelium, was strongly expressed in RA-treated epidermis.In contrast, the glycosylalion pattern of the SLS-treated epidermis was tiot significantly different frotn that observed after vehicle treatment.Thus, RA treattnent converts normal stratified epithelium towards the phenotype of mucosal epitheliutn with a decrease in T antigen and a concomitant increase in Le^.These changes iire not observed following treatment with SLS and identify an itnportant difference between RA elTects and irritancy.
Radiation-Induced Mouse Liver Neoplasms and Hepatocyte Survival&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Di Majo, Vincenzo, Coppola, Mario, Rebessi, Simonetta, Bassani, Bruno, Alati, Teresa, Saran, Anna, Bangrazi, Caterina, Covelli, Vincenzo
Journal: JNCI Journal of the National Cancer Institute (1986)

Journal Article Radiation-Induced Mouse Liver Neoplasms and Hepatocyte Survival Get access Vincenzo Di Majo, Vincenzo Di Majo Search for other works by this author on: Oxford Academic PubMed Google Scholar Mario Coppola, Mario Coppola Search for other works by this author on: Oxford Academic PubMed Google Scholar Simonetta Rebessi, Simonetta Rebessi Search for other works by this author on: Oxford Academic PubMed Google Scholar Bruno Bassani, Bruno Bassani Search for other works by this author on: Oxford Academic PubMed Google Scholar Teresa Alati, Teresa Alati Search for other works by this author on: Oxford Academic PubMed Google Scholar Anna Saran, Anna Saran Search for other works by this author on: Oxford Academic PubMed Google Scholar Caterina Bangrazi, Caterina Bangrazi Search for other works by this author on: Oxford Academic PubMed Google Scholar Vincenzo Covelli Vincenzo Covelli Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 77, Issue 4, October 1986, Pages 933–939, https://doi.org/10.1093/jnci/77.4.933 Published: 01 October 1986 Article history Received: 02 December 1985 Accepted: 04 June 1986 Published: 01 October 1986
Highlights of This Issue
Journal: Clinical Cancer Research (2010)

Multiple myeloma (MM) is a B-cell malignancy commonly characterized by chromosomal translocations.In this study, Nakashima and colleagues evaluated KW-2478, a heat shock protein 90 (Hsp90) inhibitor, in MM.By treating MM cells with KW-2478, they found that FGFR3 is a new Hsp90 client protein.They also found that two other Hsp90 client proteins, Cdk9 and phosphorylated 4E-BP1, were depleted following treatment with KW-2478, demonstrating that KW-2478 affects both transcriptional and translational pathways.Studies using an orthotopic mouse model of MM further suggested that KW-2478 could be a promising strategy for the treatment of MM.
Essentials of Prescription Writing.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trends in HIV Prevalence Among Disadvantaged Youth
Authors: George A. Conway
Journal: JAMA (1993)

<h3>Objective.</h3> —To describe trends in the prevalence of human immunodeficiency virus (HIV) among socially and educationally disadvantaged US youth. <h3>Design.</h3> —Analysis of demographic and geographic trends of HIV infection among Job Corps students from January 1988 through December 1992. <h3>Setting.</h3> —The Job Corps is a national training program for disadvantaged and out-of-school youth. <h3>Population Screened.</h3> —Youths aged 16 to 21 years who entered the Job Corps residential training centers during the survey period. <h3>Main Outcome Measure.</h3> —Trends in prevalence of HIV infection among Job Corps students stratified by sex, age, race, and region of the country. <h3>Results.</h3> —Of the 269 956 Job Corps students screened, 812 (0.3%) tested positive for the antibody to HIV type 1. Seroprevalence of HIV for young men decreased from 3.6 per 1000 in 1988 to 2.2 per 1000 in 1992 (χ<sup>2</sup>test for trend,<i>P</i>&lt;.001). Seroprevalence for young women increased from 2.1 per 1000 in 1988 to 4.2 per 1000 in 1990 (<i>P</i>=.001), with seroprevalence remaining stable from 1990 through 1992. The decreasing trends in HIV prevalence among men and increasing trends among women were primarily due to changes in seroprevalence in African-American students. <h3>Conclusions.</h3> —The overall prevalence of HIV infection of three per 1000 is high, given the youth of Job Corps students. The significant rise in HIV rates among female Job Corps students provides evidence of the increasing risk of infection for socioeconomically disadvantaged young women. Reasons for the declining trend in HIV prevalence among male Job Corps students are not clear. Efforts to prevent the spread of HIV infection among adolescents must focus on the group that is hardest to reach—out-of-school and impoverished youth. (<i>JAMA</i>. 1993;269:2887-2889)
Psychology and Its Bearing on Education
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endoscopy International Open – recently published
Journal: Endoscopy (2017)

Comment on: Use of over-the-scope clips (OTSC) for hemostasis in gastrointestinal bleeding in patients under antithrombotic therapyEndosc Int Open 2017; 05(05): E324-E330DOI: 10.1055/s-0043-104860 Comment on: Per-oral endoscopic myotomy for achalasia cardia: outcomes in over 400 consecutive patientsEndosc Int Open 2017; 05(05): E331-E339DOI: 10.1055/s-0043-105517 Comment on: Comparative quality assessment of esophageal examination with transnasal and sedated endoscopyEndosc Int Open 2017; 05(05): E340-E344DOI: 10.1055/s-0042-122008
Myocardial Infarction or Acute Myopericarditis
Authors: Jouko Karjalainen
Journal: JAMA (1983)

<h3>To the Editor.—</h3> Differentiating myocardial infarction from acute myopericarditis may be equivocal. Hanson et al (1982;248:2313) described chest pains and ECG, serum enzymatic, and technetium Tc 99m pyrophosphate scan changes of myocardial injury in a young athlete. Diagnosis of acute myocardial infarction was made, despite there being no evidence of coronary atherosclerosis or spasm; a finding of myocardial bridging was not anatomically related to that myocardial injury. In fact, all findings in this patient concur as well with acute infectious myopericarditis. Serial ECGs showed typical changes of "acute pericarditis": rather widespread initial ST-segment elevations, followed by more localized T-wave inversions<sup>1,2</sup>; no Q waves appeared despite a conspicuous elevation of creatine kinase MB level. Creatine kinase MB elevation is detected in 70% of patients who have acute myopericarditis with ST-segment elevation,<sup>2</sup>and the enzyme release simulates that in myocardial infarction— it is of short duration, not exceeding six days.
Bioinspired and Inflammation‐Modulatory Glycopeptide Hydrogels for Radiation‐Induced Chronic Skin Injury Repair
Authors: Zujian Feng, Yumin Zhang, Chunfang Yang, Xiang Liu, Yini Huangfu, Chuangnian Zhang, Pingsheng Huang, Anjie Dong, Jinjian Liu, Jianfeng Liu, Deling Kong, Weiwei Wang
Journal: Advanced Healthcare Materials (2022)

Clinical wound management of radiation-induced skin injury (RSI) remains a great challenge due to acute injuries induced by excessive reactive oxygen species (ROS), and the concomitant repetitive inflammatory microenvironment caused by an imbalance in macrophage homeostasis. Herein, a cutaneous extracellular matrix (ECM)-inspired glycopeptide hydrogel (GK@TAgel ) is rationally designed for accelerating wound healing through modulating the chronic inflammation in RSI. The glycopeptide hydrogel not only replicates ECM-like glycoprotein components and nanofibrous architecture, but also displays effective ROS scavenging and radioprotective capability that can reduce the acute injuries after exposure to irradiation. Importantly, the mannose receptor (MR) in GK@TAgel exhibits high affinity and bioactivity to drive the M2 macrophage polarization, thereby overcoming the persistent inflammatory microenvironment in chronic RSI. The repair of RSI in mice demonstrates that GK@TAgel significantly reduces the hyperplasia of epithelial, promotes appendage regeneration and angiogenesis, and decreased the proinflammatory cytokine expression, which is superior to the treatment of commercial radioprotective drug amifostine. Collectively, the ECM-mimetic hydrogel dressing can protect the tissue from irradiation and heal the chronic wound in RSI, holding great potential in clinical wound management and tissue regeneration.
A Conductive Hydrogel Microneedle‐Based Assay Integrating PEDOT:PSS and Ag‐Pt Nanoparticles for Real‐Time, Enzyme‐Less, and Electrochemical Sensing of Glucose
Authors: Peyman GhavamiNejad, Amin GhavamiNejad, Hanjia Zheng, Karan Dhingra, Melisa Samarikhalaj, Mahla Poudineh
Journal: Advanced Healthcare Materials (2022)

Abstract Continuous glucose meters (CGMs) have tremendously boosted diabetes care by emancipating millions of diabetic patients’ need for repeated self‐testing by pricking their fingers every few hours. However, CGMs still suffer from major deficiencies regarding accuracy, precision, and stability. This is mainly due to their dependency on an enzymatic detection mechanism. Here a low‐cost hydrogel microneedle (HMN)‐CGM assay fabricated using swellable dopamine (DA)‐hyaluronic acid (HA) hydrogel for glucose interrogation in dermal interstitial fluid (ISF) is introduced. Platinum and silver nanoparticles are synthesized within the 3D porous hydrogel scaffolds for nonenzymatic electrochemical sensing of the glucose. Incorporation of a highly water dispersible conductive polymer, poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) enhances the electrical properties of HMN array, making the patch suitable as the working electrode of the sensor. The in vitro and ex vivo characterization of this newly developed HMN patch is fully studied. The performance of the HMN‐CGM for real‐time measurement of glucose is also shown using a rat model of type 1 diabetes. The device introduces the first HMN‐based assay for tracking important disease biomarkers and expect to pave the way for next generation of polymeric‐based sensors.
Modifying Factors in Pancreatic Carcinogenesis in the Hamster Model. IV. Effects of Dietary Protein&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Modifying Factors in Pancreatic Carcinogenesis in the Hamster Model. IV. Effects of Dietary Protein Get access Parviz M. Pour, Parviz M. Pour 6 6Address reprint requests to Dr. Pour at the Eppley Institute for Research in Cancer and Allied Diseases. Search for other works by this author on: Oxford Academic PubMed Google Scholar Diane F. Birt Diane F. Birt Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 71, Issue 2, August 1983, Pages 347–353, https://doi.org/10.1093/jnci/71.2.347 Published: 01 August 1983 Article history Received: 19 October 1982 Accepted: 15 April 1983 Published: 01 August 1983
Acute Fatty Liver of Pregnancy
Authors: María Collado Ferrer, Linda Collado Ferrer, Alfonso Serrano
Journal: New England Journal of Medicine (1985)

A 17-year-old-female at 39 weeks gestation, presented with pelvic pain, proteinuria and a decrease in fetal heart rate. Timely caesarean section was performed. The postoperative course was complicated by acute renal failure, acute pancreatitis, acute liver failure, anemia, thrombocytopenia, systemic inflammatory response syndrome (SIRS), prolonged coagulopathy, hyperbilirubinemia, ecclampsia, and psychosis. The clinical features and laboratory abnormalities, in conjunction with the timing of gestational age, led to the diagnosis of acute fatty liver of pregnancy. Prompt diagnosis and supportive care in an intensive care unit provided for a positive outcome.
Health Insurance Values and Implementation in the Netherlands and the Federal Republic of Germany
Authors: Bradford L. Kirkman-Liff
Journal: JAMA (1991)

The health care systems in the Netherlands and the Federal Republic of Germany are based on a set of values that involve mutual obligations between private parties. These obligations are realized through systems incorporating private practice physicians, community and church- and municipality-affiliated hospitals, and nonprofit and for-profit insurers. The underlying values and implementation approaches in these systems provide an alternative to the adoption of a Canadian-style health insurance system. A discussion that focuses on "obligations" rather than "rights" may be a more useful approach for the design of reforms of the American health system in the 1990s. Such a discussion would focus on the mutual responsibility of all parties to create and maintain a universal private health care system. (<i>JAMA</i>. 1991;265:2496-2502)
Thyroid function tests
Authors: P Kendall-Taylor
Journal: BMJ (2000)

Impact of NHS Direct on demand for immediate care Target communities show poor awareness of NHS DirectEditor-Munro et al found that NHS Direct had no discernible effect on the use of emergency ambulances or accident and emergency departments in the first year of operation, leading to a suggestion that this service may not prove cost effective. 1 The study is limited by an assumption that the population studied had complete awareness of the service.Six months after the introduction of East Midlands NHS Direct we had anecdotal evidence to suggest that many patients attending our accident and emergency department were unaware of the telephone advisory service.Consequently we undertook a survey of 300 consecutive ambulatory patients (or their parents) who referred themselves to the accident and emergency department and had not contacted NHS Direct.We wanted to find out whether they were aware of the service.Altogether 266 (89%) questionnaires were completed, with 166 (62%) patients claiming to have had no previous awareness of NHS Direct.Furthermore, of the 100 patients who were aware of the service, only 36 were aware of the telephone charge while 51 thought that calls were taken by doctors.Only eight "aware" patients, however, said that they would distrust advice given by a nurse, a finding that supports a study by O'Cathain et al. 2 The survey also determined which sections of the community were unaware of NHS Direct.Patients aged over 65 (all 9), patients from ethnic minorities (41/59; 69%), patients from predominantly less affluent postcodes (101/129; 78%), and young men (20/28; 71%) were overrepresented.The survey also found that 240 (90%) patients claimed to have access to a telephone and that 56 (21%) might have been redirected away from our department by NHS Direct.In the light of these findings we would say that NHS Direct has failed to market its existence to those members of the community who frequently access urgent health care.The results of NHS Direct impact studies have consequently been confounded by this oversight.Whether a proper national publicity campaign can improve the impact of this beleaguered service remains to be seen.
Percutaneous Injuries During Operation
Authors: Ronald Lee Nichols
Journal: JAMA (1992)

Despite the high standards set for performance, equipment, and a controlled, safe environment, the modern operating room remains potentially hostile to both the patient and the surgical team.<sup>1</sup>Health hazards, although uncommonly encountered, include those of a physical, chemical, and biological nature. Prior to the early 1980s, when the human immunodeficiency virus (HIV) was found to cause the acquired immunodeficiency syndrome (AIDS), the emphasis concerning biological hazards was placed on the patient as a host for nosocomial bacterial infections. Consideration of the patient as the vector of blood-borne viral infections has evolved during the last decade—a late realization considering the 30-year knowledge that hepatitis B virus (HBV) is acquired in the workplace and has been responsible for many deaths, now estimated at over 200 health care workers (HCWs) annually.<sup>2,3</sup>It appears that the apparently uniform fatal outcome of clinical AIDS, combined with the absence of a preventive vaccine
Differentiating Parkinson Disease From Multiple-System Atrophy by Measuring Cardiac Iodine-123 Metaiodobenzylguanidine Accumulation
Authors: Hisato Takatsu
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endoscopy International Open – recently published
Journal: Endoscopy (2017)

Comment on: The efficacy of training insertion skill on a physical model colonoscopy simulatorEndosc Int Open eFirstDOI: 10.1055/s-0042-114773 Comment on: Does ampullary adenoma size predict invasion on EUS? Does invasion on EUS predict presence of malignancy?Endosc Int Open 2016; 04(12): E1313-E1318DOI: 10.1055/s-0042-121001 Comment on: Learning curve for endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of pancreatic lesions in a novel ex-vivo simulation modelEndosc Int Open 2016; 04(12): E1286-E1291DOI: 10.1055/s-0042-118176
Studies on L Cells Persistently Infected With Polyoma Virus: Relationship Between D Particle and Other Virus-Like Particles&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Kodama, Mitsuo, Kojima, Kiyohide, Kodama, Toshiko
Journal: JNCI Journal of the National Cancer Institute (1968)

Journal Article Studies on L Cells Persistently Infected With Polyoma Virus: Relationship Between D Particle and Other Virus-Like Particles Get access Mitsuo Kodama, Mitsuo Kodama Laboratory of Chemotherapy and Laboratory of Cell Biology, Aichi Cancer Center Research Institute, Nagoya, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Kiyohide Kojima, Kiyohide Kojima Laboratory of Chemotherapy and Laboratory of Cell Biology, Aichi Cancer Center Research Institute, Nagoya, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Toshiko Kodama Toshiko Kodama Laboratory of Chemotherapy and Laboratory of Cell Biology, Aichi Cancer Center Research Institute, Nagoya, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 41, Issue 2, August 1968, Pages 565–579, https://doi.org/10.1093/jnci/41.2.565 Published: 01 August 1968 Article history Received: 07 February 1968 Accepted: 17 April 1968 Published: 01 August 1968