tbuckley/cabot-search huggingface dataset:
<i>Outcomes of High-Grade B-Cell Lymphoma As Compared to Other Large B-Cell Lymphoma Subtypes in Patients Treated with CD19-Directed CAR-T Cells at 3 rd Line or More. a Lysa Study Based on the French Descart-Registry.</i>
Authors: Xavier Phina-Ziebin, Emmanuel Bachy, Francois Xavier Gros, Roberta Di Blasi, Charles Herbaux, Jacques-Olivier Bay, Sylvain Carras, Pierre Bories, René-Olivier Casasnovas, Fabrice Jardin, Franck Morschhauser, Blandine Guffroy, Elodie Gat, Julien Calvani, Marie Parrens, Elsa Poullot, Alexandra Traverse-Glehen, Louise Roulin
Journal: Blood (2023)
Outcomes of Proton Therapy to Infradiaphragmatic Sites in Pediatric Hodgkin Lymphoma Patients
Authors: Cecilia Jiang, Michele Kim, Monica Chelius, Xiaoyan Han, Travis Hoover, Leslie Kersun, Anne F Reilly, Elizabeth Cummings, Goldie Kurtz, Christine Hill-Kayser, John Plastaras, Michael Lariviere
Journal: Blood (2023)
The Prevalence of JAK2 Mutation in High-Altitude Patients with Unprovoked Thrombosis and Thrombosis at Unusual Sites
Authors: Ayel Omar Yahya, Abdullah Algarni, Omayma Saad Eldeen Bhakeet, Hassan Y Asiri, Hassan A Alasiri, Mohammed Assiri, Awad M Alwadie, Husain Yahya M Alkhaldy
Journal: Blood (2023)
Combination Epigenetic Therapy Using YF2, a First-in-Class Histone Acetyltransferase Activator, Restores Immunogenicity in Diffuse Large B-Cell Lymphoma
Authors: Ted B. Piorczynski, Yun Kyoung Ryu, Manuel Pazos, Wenxuan Huang, Seda S. Tolu, Brian Estrella, Jennifer E Amengual
Journal: Blood (2023)
Single-Cell Multiomics Analysis Reveals Potential Drivers of Response to the Anti-TIM3 Inhibitor Sabatolimab Combined with Azacitidine in MDS and CMML
Authors: Aonkon Dey, Rupa Narayan, Neal Smith, Alice Tirard, Benjamin Arnold, John McGuire, Thomas Chan, Jennifer Lombardi Story, Timothy Casson, Tanya Toni Behnan, Amir T. Fathi, Gabriela S. Hobbs, Hanno Hock, Philip C. Amrein, Patrick Reeves, Timothy Aaron Graubert, Andrew M. Brunner, Alexandra-Chloé Villani
Journal: Blood (2023)
Investigating Racially Induced Metabolic and Genomic Signatures Mediating Inferior Survival in African Americans with Acute Myelogenous Leukemia
Authors: Lacey Scott Williams, Alexis K Williams, Sarah Elizabeth Mudra, Paul Sackstein, Garrett Diltz, Rachel Zemel, Purnima Sravanti Teegavarapu, Martha P. Mims, Kimberley Doucette, Catherine Lai, Gustavo A. Rivero
Journal: Blood (2023)
Measurable Residual <i>FLT3-ITD</i> before Allogeneic Transplant for Acute Myeloid Leukemia
Authors: Laura W Dillon, Gege Gui, Niveditha Ravindra, Georgia Andrew, Devdeep Mukherjee, Zoe Wong, Ying Huang, Jason Gerhold, Matthew Holman, Jeffrey E Miller, Jeffery J. Auletta, Firas El Chaer, Steven M. Devine, Antonio M. Jimenez Jimenez, Marcos de Lima, Mark R. Litzow, Partow Kebriaei, Wael Saber, Stephen R. Spellman, Kristin M. Page, Christopher S. Hourigan
Journal: Blood (2023)
Clinical and Molecular Characterization of Triple-Negative Essential Thrombocythemia: Data from the Prospective Spanish Registry of Essential Thrombocythemia
Authors: Rodrigo Gil-Manso, Gonzalo Carreño, Juan Carlos Hernandez Boluda, Raul Perez Lopez, Maria Teresa Gómez-Casares, Francisca Ferrer Marin, Eduardo Arellano-Rodrigo, Anna Angona, Valentín García Gutiérrez, Maria Soledad Noya, María Alicia Senin, Elena Magro, Irene Pastor, María Isabel Mata, Beatriz Cuevas, Elvira Mora, Cristina Martinez, Juan M. Alonso-Dominguez, Manuel Pérez-Encinas, Gonzalo Caballero Navarro, Miguel A. Cortes Vázquez, Carmen del Río, Joaquin Martinez Lopez, Rosa Ayala, Alberto Alvarez-Larran
Journal: Blood (2023)
A Pro-Inflammatory Gene Signature Characterizes a Better Risk Aged AML Patient Group in ECOG-ACRIN Cancer Research Group's Clinical Trial E3999
Authors: Yaseswini Neelamraju, Franck Rapaport, Jorge A Gandara, Nicholas Dunham, Hao Fan, Tak Lee, Subhash Prajapati, Caroline Sheridan, Ling Wang, Larry D. Cripe, Richard Dillon, Maria Kleppe, Ross L Levine, Christopher Mason, Ari M Melnick, Elisabeth Paietta, Gail J. Roboz, Zhuoxin Sun, Martin S. Tallman, Yanming Zhang, Stefan Bekiranov, Francine E. Garrett-Bakelman
Journal: Blood (2023)
Co-Occurring Mutations in <i>ASXL1</i> and <i>SRSF2</i> Define a Unique, Prognostically Relevant Chromatin-Spliceosome Gene Signature in <i>De Novo</i> acute Myeloid Leukemia
Authors: Vikram Dhillon, Jeff Aguilar, Sushmitha Nanja Reddy, Lakshmi Bhavani Potluri, Jaroslaw P. Maciejewski, Suresh Kumar Balasubramanian
Journal: Blood (2023)
A Single Center Retrospective Analysis Comparing the Outcomes of Induction Therapy between 7+3 and FLAG-IDA/Venetoclax in Newly Diagnosed Patients with Acute Myeloid Leukemia
Authors: Peter Abdelmessieh, Asya Varshavsky-Yanovsky, Yuliya Shestovska, Rashmi Khanal, Michael Styler, Brittany Ballas, Forrest Ridgway, Michele Sorrentino, Anne Ojala, Henry C. Fung
Journal: Blood (2023)
Precision Lineage Deconvolution in Mixed Phenotype Acute Leukemia Using Cite-Seq Derived Hematopoietic Stages Identifies Lineage Dynamics Associated with Treatment Response
Authors: Deepika Dilip, Pallavi Galera, David Nemirovsky, Morgan Lallo, Kamal Menghrajani, Andriy Derkach, Ross L Levine, Richard Koche, Wenbin Xiao, Jacob Glass
Journal: Blood (2023)
Clonal Trafficking of Individual T Cells between Peripheral Blood and Inflamed Synovial Tissue in Patients with Immune-Mediated Refractory Arthritis
Authors: Dipabarna Bhattacharya, Jason Theodoropoulos, Katariina Nurmi, Timo Juutilainen, Kari K Eklund, Riitta Koivuniemi, Tiina Kelkka, Satu Mustjoki, Tapio Lönnberg
Journal: Blood (2023)
High Success Rates Utilizing Local Standard of Care Cytogenetic Testing for Risk Stratified Frontline Therapy for Newly Diagnosed Multiple Myeloma: Experience from the Ukmra RADAR Study
Authors: Dipal Mehta, Laura Chiecchio, Martin F. Kaiser, Sarah Gooding, Kara-Louise Royle, Doina Levinte, Catherine Olivier, David Allan Cairns, Lorna Barnard, Sharon Jackson, Robert Cicero, Gordon Cook, Michael A. Chapman, Alan Chant, David Meads, Bryony Dawkins, Guy Pratt, Rakesh Popat, Graham Jackson, Ceri Bygrave, Andrew Chantry, Jonathan Sive, Christopher Parrish, Dean Smith, Mark Drayson, Roger Owen, Ruth M de Tute, Karthik Ramasamy, Kwee Yong, Matthew W. Jenner
Journal: Blood (2023)
The Human Leukemia Immunopeptidome Is Driven By Pathogenic Molecular Variant Biotypes
Authors: Paul Sackstein, Garrett Diltz, Lacey Scott Williams, Rachel Zemel, Sarah Elizabeth Mudra, Anne S. Renteria, Olga Timofeeva, Kimberley Doucette, Purnima Sravanti Teegavarapu, Gustavo A. Rivero
Journal: Blood (2023)
Integrative Multi-Omic Analysis for Prognosis Stratification in Acute Myeloid Leukemia
Authors: Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Chunlin Zhou, Dong Lin, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi
Journal: Blood (2023)
Daratumumab Bortezomib and Dexamethasone in Transplant Ineligible Newly Diagnosed Elderly Myeloma Patients - a Trial By Asian Myeloma Network
Authors: Chandramouli Nagarajan, Melinda Tan, Yunxin Chen, Melissa Ooi, Sanjay De Mel, Allison Tso, Lawrence Ng, Hein Than, Yeow Tee Goh, Brian GM Durie, Wee-Joo Chng
Journal: Blood (2023)
Evaluation of CD70 Chimeric Antigen Receptor T (CAR-T) Cells As a Potential Treatment for Non-Hodgkin's Lymphoma: A Preclinical Study
Authors: Pengfei Jiang, Qinghui Xiong, Xiujie Yuan, Haoyu Zhang, Qiushuang Shen, Yang Wang, Yiwei Gong
Journal: Blood (2023)
A Large Cohort Study of 412 Patients with <i>SRSF2/TET2</i> Co-Mutated Myeloid Neoplasms: The Molecular Landscape and Clinical Outcomes
Authors: Samuel G Cockey, Hailing Zhang, Mohammad Omar Hussaini, Ling Zhang, Lynn C. Moscinski, Ethan Yang, Jinming Song
Journal: Blood (2023)
Investigating Health Literacy in Thalassemia: Founding a Patient-Led Research Approach
Authors: Sujit Sheth, Ralph Colasanti, Lily Cannon, Jill Deitrick, Holly John, Keely S Gilroy, Louise Lombard, Eleni Michalaki, Tobias Larkin, Laurice M Levine, Dina Steagall, Maria Domenica Cappellini
Journal: Blood (2023)
Descriptive and Epidemiological Study of Joint Damage in Non-Severe Hemophilia: Update of the Damage Study of the Mediterranean Group
Authors: Ana Marco Rico, Jose Manuel Calvo-Villas, Francisco Jose Lopez Jaime, Mariana Canaro Hinryk, Sonia Herrero-Martín, Laura Entrena Ureña, Shally Marcellini Antonio, Maria del Mar Nieto, Bolivar Diaz Jordan, Covadonga Garcia Diaz, Sergio Jurado Herrera, Faustino García Candel, Miguel Blanquer Blanquer, Pascual Marco VERA, Ihosvany Fernandez-Bello
Journal: Blood (2023)
Newly Identified Roles for PIEZO1 Mechanosensor in Controlling Normal Megakaryocyte Development and in Primary Myelofibrosis
Authors: Iris Karkempetzaki, Vittorio Abbonante, Catherine Leon, Nasi Huang, Christian Di Buduo, Daniele Cattaneo, Christina Ward, Shinobu Matsuura, Alessandra Iurlo, Alessandra Balduini, Katya Ravid
Journal: Blood (2023)
Overall Survival in Advanced Stage Mantle Cell Lymphoma after Early Autologous Stem Cell Transplantation with Cisplatin, Etoposide, Cytarabine and Melphalan (PEAM) As a Conditioning Regimen
Authors: Daniel Franco, Fernando Tellez, Ruben Solis-Armenta, Araceli Leal Alanis, Carlos Cruz Castillo, Luis Manuel Valero Saldaña, Brenda Lizeth Acosta Maldonado
Journal: Blood (2023)
Idarubicin and Cytarabine with and without Midostaurin for FLT3-Mutated Acute Myeloid Leukemia
Authors: Kendall Diebold, Sarah Worth, Kimo Bachiashvili, Pankit Vachhani, Sravanti Rangaraju, Manuel Espinoza-Gutarra, Zaid Al-Kadhimi, Ravi Bhatia, Omer Jamy
Journal: Blood (2023)
The Impact of Anti-T-Lymphocyte-Globulin Dosing on Gvhd in Matched Sibling Allogeneic Stemcell Transplantation
Authors: Radwan Massoud, Ameya Shrinivas Kunte, Evgeny Klyuchnikov, Anita Badbaran, Christian Niederwieser, Dietlinde Janson, Christine Wolschke, Francis A. Ayuk, Nicolaus Kröger
Journal: Blood (2023)
Daratumumab-Based Maintenance in Patients with Relapsed Multiple Myeloma after Salvage Autologous Hematopoietic Stem Cell Transplantation
Authors: Oren Pasvolsky, Krina K. Patel, Qaiser Bashir, Mikael Rauf, Dawen Sui, Samer A. Srour, Mark R. Tanner, Uday R. Popat, Neeraj Y. Saini, Chitra Hosing, Jeremy Ramdial, Elisabet E. Manasanch, Hans C. Lee, Gregory P. Kaufman, Sheeba K. Thomas, Donna M. Weber, Melody R. Becnel, Guilin Tang, Robert Z. Orlowski, Dipa Patel, Richard E. Champlin, Yago Nieto, Elizabeth J. Shpall, Muzaffar H. Qazilbash
Journal: Blood (2023)
First-in-Human Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Factor XI Monoclonal Antibody SHR-2004 in Healthy Subjects
Authors: Tingting Ma, Bei Cao, Zuyi Weng, Yanli Dong, Shimin An, Lei Huang, Yuanxun Yang, Yan Geng, Hui Lin, Yuqi Wang, Pinhao Xie, Kai Shen, Juan Li
Journal: Blood (2023)
Dissecting Subtype-Specific Tumor-Time Interactions and Underlying Hidden Drivers in Pediatric Acute Myeloid Leukemia Via Single-Cell Multi-Omics
Authors: Jiyuan Yang, Sheetal Bhatara, Masayuki Umeda, Shanshan Bradford, SongEun Lim, Tamara Westover, Jing Ma, Lauren Ezzell, Jeffery Klco, Jiyang Yu
Journal: Blood (2023)
A Novel Selective BCL2 Inhibitor with Limited Immune Suppression and Improved Safety Compared to Venetoclax
Authors: Chia Sharpe, Sara Elgamal, Sydney Fobare, Casie Furby, Marissa Long, Kinsey Bryant, Carolyn Cheney, James R. Lerma, Megan E. Johnstone, Andrew Orry, Polo Chun-Hung Lam, Ruben Abagyan, Volodymyr Kysil, Hovhannes Gukasyan, Oleg Mitkin, Ruben Karapetian, Alexey Ryakhovskiy, Elena Bulanova, Vladislav Parchinsky, Alexandre Ivachtchenko, Kate Dokukina, Alexei Pushechnikov, Nikolay Savchuk, Iain Dukes, Amy Burd, Erin K. Hertlein, John C. Byrd
Journal: Blood (2023)
Early Predictors of Severe Cytopenia Post CAR-T for Identification of Patients for Potential Stem Cell Collection
Authors: Andre De Menezes Silva Corraes, Radhika Bansal, Larissa Argenau Marques Brunaldi, Sikander Ailawadhi, Arushi Khurana, Paul J Hampel, Urshila Durani, David Dingli, Suzanne R. Hayman, Prashant Kapoor, Yucai Wang, Moritz Binder, Saad S. Kenderian, Taxiarchis Kourelis, Rahma M Warsame, N. Nora Bennani, Morie A. Gertz, Patrick B Johnston, Stephen M Ansell, Rafael Fonseca, P. Leif Bergsagel, Shaji Kunnathu Kumar, Ricardo Parrondo, Saurabh Chhabra, Yi Lin
Journal: Blood (2023)
Risk and Response Adapted Approach for Treatment of Myeloma: Pushing Autologous Transplant Down the Hierarchy
Authors: Aakanksha Singh, Reema Singh, Rohan Halder, Karuna Jha, Tribikram Panda, Amir Khan Maroof, Niharika Bhatia, Rayaz Ahmed, Dinesh Bhurani, Narendra Agrawal
Journal: Blood (2023)
Differences in Observed Toxicities for Adolescent and Young Adult Patients with Aggressive Mature B-Cell Lymphomas Treated at Adult Versus Pediatric Cancer Center - a Comparative Cohort Study
Authors: Allison M Lehanka, Ann Kebede, Neda Amirmokhtari, Joseph R Stanek, Narendranath Epperla, Beth Christian, Robert Baiocchi, Timothy Voorhees, Kami J. Maddocks, Yazeed Sawalha, John C Reneau, Jonathan E. Brammer, Audrey M. Sigmund, Faye Willen, Nick Yeager, Anthony N. Audino, David A. Bond
Journal: Blood (2023)
Acquired microRNA-142 Deficit Drives Escape Mechanisms of Anti-Leukemic Surveillance during Blast Crisis Transformation of Chronic Myeloid Leukemia (CML)
Authors: Fang Chen, Dandan Zhao, Yi Zhang, Yongfang Xu, Min-Hsuan Chen, Khyatiben V. Pathak, Yong Liang, Wei-Le Wang, Katrina Estrella, Xiwei Wu, Lucy Y. Ghoda, Ya-Huei Kuo, Haris Ali, Jianhua Yu, Michael A Caligiuri, Mark Boldin, Piotr Swiderski, Marcin Kortylewski, Patrick Pirrotte, Le Xuan Truong Nguyen, Guido Marcucci, Bin Zhang
Journal: Blood (2023)
Deep Learning Based Blood Abnormalities Detection As a Tool for Vexas Syndrome Screening
Authors: Cedric De Almeida Braga, Maxence Bauvais, Pierre Sujobert, Mael Heiblig, Maxime Jullien, Baptiste Le Calvez, Camille Richard, Valentin Le Roc'h, Emmanuelle Rault, Olivier Herault, Pierre Peterlin, Alice Garnier, Patrice Chevallier, Simon Bouzy, Yannick LE Bris, Antoine Neel, Julie Graveleau, Perrine Paul-Gilloteaux, Olivier Kosmider, Nicolas Normand, Marion Eveillard
Journal: Blood (2023)
Delayed Intensification Including Venetoclax and Bortezomib Prolongs Survival in Very High Risk Acute Lymphoblastic Leukaemia
Authors: Jasmeet Sidhu, Arijit Chakraborty, Parag Das, Manash Pratim Gogoi, Tanima Dey, Fabio D. Steffen, Sangramjit Basu, Debdutta Ganguli, Debjani Ghosh, Niharendu Ghara, Subhajit Kundu, Abhirupa Kar, Beat Bornhauser, Jean-Pierre Bourquin, Vaskar Saha, Shekhar Krishnan
Journal: Blood (2023)
A Phase II Study of Isatuximab in Combination with Pomalidomide and Dexamethasone in Patients with Multiple Myeloma Progressing on or after One Line of Lenalidomide-Containing Therapy
Authors: Evangelos Terpos, Maria Gavriatopoulou, Eirini Katodritou, Argiris Symeonidis, Anastasia Pouli, Ioannis Ntanasis-Stathopoulos, Panagiotis Malandrakis, Despina Fotiou, Magdalini Migkou, Foteini Theodorakakou, Vasiliki Spiliopoulou, Rodanthi Syrigou, Evangelos Eleutherakis-Papaiakovou, Ioannis Ninos, Sosana Delimpasi, Eleftheria Hatzimichael, Efstathios Kastritis, Meletios A. Dimopoulos
Journal: Blood (2023)
Health Care Resource Use, Comorbidities, and Costs of Hemophilia B Patients in France: A Nationwide Claims Database Analysis
Authors: Laurent Frenzel, Véronique Cahoreau, Nicolas Giraud, Stephanie Delienne, Francis Fagnani, Stéphane Bouée, Juliette Cottin, Isabelle Bureau, Jeremie Rudant, Anais Reynaud, Amelie Coumert, Herve Lilliu, Aurelien Lebreton
Journal: Blood (2023)
Retrospective Single Center Descriptive Analysis of a Cohort with Hypereosinophilia Evaluated in the Last Decade
Authors: Julia Ribes-Amoros, Esther Alonso, Isabel Granada, Lurdes Zamora, Montserrat Arnan Sangerman, Fina Climent, Helena Pomares, Clara Maluquer Artigal, Jasson Villarreal Hernandez, Teresa Quiñones, Iago Arribas, Shiomara Quiñones, Maria Isabel Sotelo, Maria Teresa Encuentra, Mònica Fernandez-Benages, Adela Cisneros, Jan Bosch-Schips, Miriam Ratia, Anna Maria Sureda Balari, María Alicia Senin
Journal: Blood (2023)
Enhanced CD1d phosphatidylserine presentation using a single-domain antibody promotes immunomodulatory CD1d-TIM-3 interactions
Authors: Roeland Lameris, Adam Shahine, Myrthe Veth, Bart Westerman, Dale I Godfrey, David Lutje Hulsik, Patricia Brouwer, Jamie Rossjohn, Tanja D de Gruijl, Hans J van der Vliet
Journal: Journal for ImmunoTherapy of Cancer (2023)

Background CD1d is a monomorphic major histocompatibility complex class I-like molecule that presents lipid antigens to distinct T-cell subsets and can be expressed by various malignancies. Antibody-mediated targeting of CD1d on multiple myeloma cells was reported to induce apoptosis and could therefore constitute a novel therapeutic approach. Methods To determine how a CD1d-specific single-domain antibody (VHH) enhances binding of the early apoptosis marker annexin V to CD1d + tumor cells we use in vitro cell-based assays and CRISPR-Cas9-mediated gene editing, and to determine the structure of the VHH1D17-CD1d(endogenous lipid) complex we use X-ray crystallography. Results Anti-CD1d VHH1D17 strongly enhances annexin V binding to CD1d + tumor cells but this does not reflect induction of apoptosis. Instead, we show that VHH1D17 enhances presentation of phosphatidylserine (PS) in CD1d and that this is saposin dependent. The crystal structure of the VHH1D17-CD1d(endogenous lipid) complex demonstrates that VHH1D17 binds the A′-pocket of CD1d, leaving the lipid headgroup solvent exposed, and has an electro-negatively charged patch which could be involved in the enhanced PS presentation by CD1d. Presentation of PS in CD1d does not trigger phagocytosis but leads to greatly enhanced binding of T-cell immunoglobulin and mucin domain containing molecules (TIM)-1 to TIM-3, TIM-4 and induces TIM-3 signaling. Conclusion Our findings reveal the existence of an immune modulatory CD1d(PS)-TIM axis with potentially unexpected implications for immune regulation in both physiological and pathological conditions.
Targeting Venetoclax Resistance in <i>TP53</i>-Mutated Acute Myeloid Leukemia
Authors: Ida Vänttinen, Tanja Ruokoranta, Joseph J Saad, Sari Kytölä, Monica Hellesøy, Stein-Erik Gullaksen, Pia-Sofia Ettala, Marja Pyörälä, Johanna Rimpiläinen, Timo Siitonen, Krister Wennerberg, Bjorn T. Gjertsen, Caroline A. Heckman, Mika Kontro, Heikki Kuusanmäki
Journal: Blood (2023)
Treatment of Relapsed/Refractory Hgbcl and Bukitt's Lymphoma with c-Myc Rearrangement: A Multi-Center, Open-Label, Phase 2 Study of PC-002 (SepB), a First-in-Class Deubiquitinase Inhibitor Inducing Myc Degradation
Authors: Sung-Soo Yoon, Zhiming Li, Keshu Zhou, Xiaoxi Zhou, Ye Guo, Huilai Zhang, Ki-Seong Eom, Seok Jin Kim, Sung Yong Oh, Sung-Nam Lim, Hagop Youssoufian, Vernon Jiang, Zhanchun Huang, Georgina Kilfoil, Xin Wang, Zhixiang Cao, Xiang LI, Yihai Lin, Alexander Wu, Yiyou Chen, Yuqin Song
Journal: Blood (2023)
Glutamine Metabolism Is Altered in Myeloproliferative Neoplasms and Represents a Potential Novel Therapeutic Target
Authors: Chad Coen, Jizhi Yan, Caner Saygin, Nicole Arellano, Mirielle Nauman, Katarzyna Zawieracz, Daniele Vanni, Silvia Catricalà, Ilaria Carola Casetti, Oscar Borsani, Elisa Rumi, Daniela Pietra, Shannon Elf, Hunter Blaylock
Journal: Blood (2023)
A Phase 1, Open-Label, Dose Escalation and Dose Expansion Study of CLN-978 (CD19XCD3XHSA) in Patients with Relapsed/Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (B-NHL)
Authors: Geoffrey P. Shouse, Kristie A. Blum, Julie E. Haydu, Jeremy S. Abramson, Mayur Narkhede, Andrew Ip, Jennifer S. Michaelson, Patrick A. Baeuerle, Kristan Meetze, Irina Shapiro, Todd Shearer, Judith Inumerable, Jeff Jones, Farrukh T. Awan
Journal: Blood (2023)
Hemogram Derived Clinical Traits Evinced Differential Contribution to Explained Variance of Mortality Risk Model at Index Hospitalization for Sars-Cov-2 Infection across Wuhan/D614G, Delta, Omicron and Omicron BA.x Variants
Authors: Gustavo Garcia, Maha Hameed, Zeina Kayali, Karen Hamad, Wilhelmine Wiese-Rometsch, Precious Idogun, Anjan J. Patel
Journal: Blood (2023)
Targeting integrin α5 in fibroblasts potentiates colorectal cancer response to PD-L1 blockade by affecting extracellular-matrix deposition
Authors: Ling Lu, Yaohui Gao, Dengfeng Huang, Hu Liu, Dingzi Yin, Man Li, Jiayi Zheng, Shufei Wang, Weijun Wu, Li Zhao, Dexi Bi, Youhua Zhang, Feifei Song, Ruting Xie, Jifeng Wang, Huanlong Qin, Qing Wei
Journal: Journal for ImmunoTherapy of Cancer (2023)

Background One reason patients with cancer cannot benefit from immunotherapy is the lack of immune cell infiltration in tumor tissues. Cancer-associated fibroblasts (CAFs) are emerging as central players in immune regulation that shapes tumor microenvironment (TME). Earlier we reported that integrin α5 was enriched in CAFs in colorectal cancer (CRC), however, its role in TME and cancer immunotherapy remains unclear. Here, we aimed to investigate the role for integrin α5 in fibroblasts in modulating antitumor immunity and therapeutic efficacy combined with checkpoint blockade in CRC. Methods We analyzed the CRC single-cell RNA sequencing (scRNA-seq) database to define the expression of ITGA5 in CRC tumor stroma. Experimentally, we carried out in vivo mouse tumor xenograft models to confirm the targeting efficacy of combined α5β1 inhibition and anti-Programmed death ligand 1 (PD-L1) blockade and in vitro cell-co-culture assay to investigate the role of α5 in fibroblasts in affecting T-cell activity. Clinically, we analyzed the association between α5 expression and infiltrating T cells and evaluated their correlation with patient survival and immunotherapy prognosis in CRC. Results We revealed that ITGA5 was enriched in FAP -CAFs. Both ITGA5 knockout fibroblasts and therapeutic targeting of α5 improved response to anti-PD-L1 treatment in mouse subcutaneous tumor models. Mechanistically, these treatments led to increased tumor-infiltrating CD8 + T cells. Furthermore, we found that α5 in fibroblasts correlated with extracellular matrix (ECM)-related genes and affected ECM deposition in CRC tumor stroma. Both in vivo analysis and in vitro culture and cell killing experiment showed that ECM proteins and α5 expression in fibroblasts influence T-cell infiltration and activity. Clinically, we confirmed that high α5 expression was associated with fewer CD3 + T and CD8 + T cells, and tissues with low α5 and high CD3 + T levels correlated with better patient survival and immunotherapy response in a CRC cohort with 29 patients. Conclusions Our study identified a role for integrin α5 in fibroblasts in modulating antitumor immunity by affecting ECM deposition and showed therapeutic efficacy for combined α5β1 inhibition and PD-L1 blockade in CRC.
A Phase 1 Study of CD38-Bispecific Antibody (XmAb18968) for Patients with Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia
Authors: Guru Subramanian Guru Murthy, Bijal D. Shah, Adam S Duvall, Jessica T. Leonard, Talha Badar, Cecilia Y. Arana Yi, Tyce Kearl, Arielle Baim, Alexandra M. Harrington, Aniko Szabo, Ehab L. Atallah
Journal: Blood (2023)
A Retrospective Study on Outcomes of Secondary CNS Lymphoma: Pattern of Relapse, Prognostic Factors, and Role of Consolidation Therapy
Authors: Aditi Saha, Junmin Whiting, Mohammad Ammad-ud-din, Cole Powell, Kristen Flores, Felix Sanjay, Humaira Sarfraz, Khushali Jhaveri, Michael V. Jaglal, Katherine Tobon, Hayder Saeed, Celeste M. Bello, Bijal D. Shah, Leidy Lismeris Isenalumhe, Javier Pinilla-Ibarz, Lubomir Sokol, Julio C Chavez, Ning Dong
Journal: Blood (2023)