tbuckley/cabot-search huggingface dataset:
Books in Brief
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ulcerative Colitis of the Ileum and Regional Enteritis of the Colon
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recommendations for Zidovudine: Early Infection
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Linking hypothetical knowledge patterns to disease molecular signatures for biomarker discovery in Alzheimer's disease
Authors: Ashutosh Malhotra, Erfan Younesi, Shweta Bagewadi, Martin Hofmann-Apitius
Journal: Genome Medicine (2014)

Background: A number of compelling candidate Alzheimer's biomarkers remain buried within the literature.Indeed, there should be a systematic effort towards gathering this information through approaches that mine publicly available data and substantiate supporting evidence through disease modeling methods.In the presented work, we demonstrate that an integrative gray zone mining approach can be used as a way to tackle this challenge successfully.Methods: The methodology presented in this work combines semantic information retrieval and experimental data through context-specific modeling of molecular interactions underlying stages in Alzheimer's disease (AD).Information about putative, highly speculative AD biomarkers was harvested from the literature using a semantic framework and was put into a functional context through disease-and stage-specific models.Staging models of AD were further validated for their functional relevance and novel biomarker candidates were predicted at the mechanistic level.Results: Three interaction models were built representing three stages of AD, namely mild, moderate, and severe stages.Integrated analysis of these models using various arrays of evidence gathered from experimental data and published knowledge resources led to identification of four candidate biomarkers in the mild stage.Mode of action of these candidates was further reasoned in the mechanistic context of models by chains of arguments.Accordingly, we propose that some of these 'emerging' potential biomarker candidates have a reasonable mechanistic explanation and deserve to be investigated in more detail.Conclusions: Systematic exploration of derived hypothetical knowledge leads to generation of a coherent overview on emerging knowledge niches.Integrative analysis of this knowledge in the context of disease mechanism is a promising approach towards identification of candidate biomarkers taking into consideration the complex etiology of disease.The added value of this strategy becomes apparent particularly in the area of biomarker discovery for neurodegenerative diseases where predictive biomarkers are desperately needed.
Randomized Controlled Trial of Single-Agent Paclitaxel Versus Cyclophosphamide, Doxorubicin, and Cisplatin in Patients With Recurrent Ovarian Cancer Who Responded to First-Line Platinum-Based Regimens
Authors: M. G. Cantù, A. Buda, G. Parma, R. Rossi, I. Floriani, C. Bonazzi, T. Dell’Anna, V. Torri, N. Colombo
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To assess the activity, efficacy, and tolerability of single-agent paclitaxel and a platinum-containing regimen in previously treated patients with recurrent ovarian cancer. PATIENTS AND METHODS: Patients who achieved complete remission with platinum-based regimens and whose disease recurred after a progression-free interval of more than 12 months were included in the study. Every 21 days, patients received paclitaxel 175 mg/m 2 intravenously (IV) over 3 hours or cyclophosphamide 500 mg/m 2 , doxorubicin 50 mg/m 2 , and cisplatin 50 mg/m 2 (CAP) IV. RESULTS: Between June 1992 and May 1995, 97 consecutive patients with assessable or measurable disease were randomized to paclitaxel (n = 50) or CAP (n = 47). The median number of cycles on each arm was six. Toxicities included grade 3/4 leukopenia (4% for paclitaxel v 34% for CAP), grade 3/4 neutropenia (13% v 36%), grade 1/2 myalgia (19% v 4%), allergic reactions (15% v 2%), and grade 2/3 nausea and vomiting (17% v 51%). Complete responses were achieved in 17% and 30% of patients receiving paclitaxel and CAP, respectively, and partial responses were achieved in 28% and 25%, respectively (P = .062). At a median follow-up time of 49 months, median progression-free intervals were 9 months for paclitaxel and 15.7 months for CAP (Cox analysis: hazards ratio [HR], 0.60; 95% confidence interval [CI], 0.37 to 0.97; P = .038); median overall survival times were 25.8 months for paclitaxel and 34.7 months for CAP (Cox analysis: HR, 0.58; 95% CI, 0.34 to 0.98; P = .043). CONCLUSION: Rechallenge with either single-agent paclitaxel or platinum-based chemotherapy is effective in this patient population. Preliminary results suggest that single-agent paclitaxel may not be as active as platinum-based chemotherapy in recurrent ovarian cancer. Larger randomized trials are needed.
OHRP and Standard-of-Care Research
Journal: New England Journal of Medicine (2014)

The U.S. Office of Human Research Protection (OHRP) has just issued draft guidance on the elements of informed consent it will require when research is conducted to evaluate treatment options within the current standard of care. The draft guidance (available at www.hhs.gov/ohrp/newsroom/rfc/comstdofcare.html) is open for public comment until December 23, 2014.OHRP regulations should provide a practical, fair approach to research on treatments that study subjects might have received from their physicians in the course of normal practice. However, this draft guidance is written in complex and ambiguous legalistic language that makes it difficult to determine exactly what behavior will . . .
Adjuvant chemotherapy of breast cancer. Summary of an NIH consensus statement.
Journal: BMJ (1980)

A consensus development conference on adjuvant chemotherapy of breast cancer was held at the National Institutes of Health on 14-16 July 1980.Its purpose was to bring together practising physicians, research scientists, consumers, and others in an effort to reach general agreement on the concepts and results of adjuvant chemotherapy trials in breast cancer and their implications for medical practice.A consensus development panel met to consider, together with members of the audience, the questions presented below.The members of the panel included a patient and representatives from the many disciplines concerned in evaluating and treating breast cancer.The panel met after formal presentations and discussions to assess the issues based on the evidence presented.This summary is the result of its deliberations.
Potential predictive and prognostic biomarkers identified in baseline plasma samples from the VELOUR trial.
Authors: Tasha Nicholle Sims, Bo Gao, Marielle Chiron, Pierre Mancini, Emmanuelle Dochy, Israel Lowy
Journal: Journal of Clinical Oncology (2015)

e14536 Background: Biomarkers of resistance or susceptibility to vascular endothelial growth factor (VEGF) inhibition have not been validated. Ziv-aflibercept (ZT, ZALTRAP), a fusion protein that binds and neutralizes VEGF-A, PlGF, and VEGF-B, is approved for the treatment of metastatic colorectal cancer (mCRC) in combination with FOLFIRI in patients who have progressed after oxaliplatin therapy. We are currently analyzing plasma samples from VELOUR, the 1226 patient, phase 3 registration trial of FOLFIRI +/- ziv-aflibercept, in an effort to identify prognostic and predictive factors. Methods: Retrospective analysis of 98 circulating proteins from 553 baseline plasma samples was performed. Biomarker values were first dichotomized around the median and analyzed with respect to survival (OS & PFS) and response rate. Results: The biomarker study sub-population was similar to the overall VELOUR population. For OS, the hazard ratio (HR) was 0.809 in the plasma biomarker population vs. 0.817 in the overall population. Patient demographics were similar between the groups. Several biomarkers were identified as potentially predictive or prognostic of OS, with a HR < 0.7; PFS and response were also consistent. Univariate analysis identified several plasma proteins as potential predictive markers of ZT+FOLFIRI treatment. Three markers are directly related to the mechanism of action of ZT: VEGF-A and VEGF-R2/-R3. IL-8, MIF and Surfactant Protein D, which are involved in inflammation, were also identified as potential predictive markers. Multivariate analyses are ongoing; prior bevacizumab treatment was not a significant variable in these ongoing analyses. Conclusions: Multiple immune and angiogenic potential prognostic and predictive biomarkers were identified in VELOUR. This univariate analysis suggests that mCRC patients with high VEGF/VEGF-R2/-R3 and some inflammation molecules may have better outcomes when treated with ziv-aflibercept + FOLFIRI compared to FOLFIRI alone. These results are exploratory and require prospective studies for validation. Further investigation of this dataset continues, including further multivariate analyses and analyses of on-treatment plasma samples.
DNA Damage-Inducible Genes as Biomarkers for Exposures to Environmental Agents
Authors: Neil F. Johnson, Thomas R. Carpenter, Richard J. Jaramillo, Teresa A. Liberati
Journal: Environmental Health Perspectives (1997)

A biodosimetric approach to determine alpha-particle dose to the respiratory tract epithelium from known exposures to radon has been developed in the rat.Cytotoxicity assays have been used to obtain dose-conversion factors for cumulative exposures typical of those encountered by underground uranium miners.However, this approach is not sensitive enough to derive doseconversion factors for indoor radon exposures.The expression of DNA damage-inducible genes is being investigated as a biomarker of exposure to radon progeny.Exposure of cultures of A549 cells to alpha particles resulted in an increase in the protein levels of the DNA damage-inducible genes, p53, Cip1, and Gadd45.These protein changes were associated with a transient arrest of cells passing through the cell cycle.This arrest was typified by an increase in the number of cells in the G, and G2 phases and a decrease in the number of cells in the S phase.The effect of inhaled alpha particles (radon progeny) in rats was examined in the epithelial cells of the lateral wall of the anterior nasal cavity.Exposures to radon progeny resulted in a significant increase in the number of cells in the G, phase and a decrease in the number of cells in the S phase.These cell-cycle changes were concomitant with an increase in the number of cells containing DNA strand breaks.These results suggest a commonality between cell-cycle events in vitro and in vivo following exposure to ionizing radiation.In addition to ionizing radiation, A549 cells were exposed to 4-nitroquinoline-1 -oxide, methyl methanesulphonate, crocidolite asbestos, and glass microfiber.These studies showed that physical and chemical agents induce different expression patterns of p53, Cipl, and Gaddl 53 proteins and they could be used to discriminate between toxic and nontoxic materials such as asbestos and glass microfiber.The measurement of gene expression in A549 cells may provide a means to identify a broad spectrum of physical and chemical toxicants encountered in the environment.
High sustained response rate and clearance of viremia in chronic hepatitis C after treatment with interferon-α2b for 60 weeks
Authors: O Reichard
Journal: Hepatology (1994)

To evaluate the effect of prolonged interferon-α treatment on serum aminotransferase levels and hepatitis C virus RNA in serum, 40 patients with chronic hepatitis C virus infection were treated with 3 MU interferon-α2b thrice weekly for 60 wk. Before treatment all patients had elevated serum ALT levels for at least 1 yr, antibodies to HCV by second-generation tests and liver histological findings consistent with chronic hepatitis C. Before treatment hepatitis C virus RNA was found in serum in 39 of 40 (97.5) patients. Normalization of ALT levels at treatment cessation was seen in 24 of 40 (60) patients, of whom 15 of 24 (62.5) had sustained ALT responses up to 24 wk after treatment. At follow-up, 24 wk after treatment, hepatitis C virus RNA was cleared from serum in 17 of 40 (42.5) patients, including all sustained responders, one nonsustained responder and one nonresponder. We conclude that 60 wk of treatment with interferon-α2b seems to induce a high percentage of sustained response, which coincides with cessation of viral replication. (Hepatology 1994; 19:280–285).
From the Alcohol, Drug Abuse, and Mental Health Administration
Authors: E. M. Johnson
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Upper GI tract - general
Authors: R Barbera, C Feinle, N Read, I Wilson, A Pryde, R Grant+, R Heading
Journal: Gut (1993)

Dysphagia is one of the most distressing symptoms of advanced bulbar MND.Treatment by cr-icopharyngeal myotomy has been used for almost 30 years but is successful in only a minority of patients.The rationale
Human monoclonal antibodies from a patient with primary biliary cirrhosis that recognize two distinct autoepitopes in the E2 component of the pyruvate dehydrogenase complex
Authors: M Matsui
Journal: Hepatology (1993)

Peripheral B lymphocytes from a patient with primary biliary cirrhosis were infected with Epstein-Barr virus, and Epstein-Barr virus–transformed B lymphocytes producing large amounts of IgG antibodies to pyruvate dehydrogenase complex were selected, expanded and fused with the human-mouse heteromyeloma cell line F3B6. The resulting Epstein-Barr virus–transformed B-cell hybrids were repeatedly cloned by limiting dilution, and three stable hybridoma clones producing human monoclonal antibodies to pyruvate dehydrogenase complex were generated. These monoclonal antibodies, designated M18GP8, M37GP11 and M82GP8, specifically bound to pyruvate dehydrogenase complex, and their dissociation constant with pyruvate dehydrogenase complex was calculated to be 2.4 × 10−11, 2.3 × 10−10 and 2.6 × 10−11 mol/L, respectively. These three monoclonal antibodies stained the mouse stomach/kidney cryostat sections in a typical immunofluorescence pattern of antimitochondrial antibody. Furthermore, the enzymatic activity of pyruvate dehydrogenase complex was almost completely inhibited by the three monoclonal antibodies. Western blotting analysis revealed that M18GP8 and M82GP8 reacted with only pyruvate dehydrogenase complex-E2 in contrast to M37GP11, which reacted with both pyruvate dehydrogenase complex-E2 and protein X. The binding of monoclonal antibody M37GP11 to solid-phase pyruvate dehydrogenase complex was partially inhibited by two different synthetic peptides corresponding to both the inner and outer lipoyl-binding domains of pyruvate dehydrogenase complex-E2. These monoclonal antibodies, which are the first human monoclonal antibodies to pyruvate dehydrogenase complex generated from a patient with primary biliary cirrhosis, will be a valuable tool for studying the B-cell autoepitopes in PDC and the mechanism of autoantibody production in primary biliary cirrhosis. (HEPATOLOGY 1993;18:1069-1077).
Renal failure following contrast injection for computerized tomography
Authors: J. Hanaway
Journal: JAMA (1977)

ACUTE renal failure after injection of contrast dye is a rare but well-known complication of intravenous urography and angiography.<sup>1-3</sup>Many physicians are not aware that the latest indication for routine use of contrast dye is computerized tomography (CT), where contrast media may demonstrate lesions not visualized without the dye. We report the occurrence of acute renal failure after injection of contrast media during CT scanning; to our knowledge, this is the first such report. <h3>Report of Cases</h3><h3>Case 1. —</h3> A 72-year-old woman had a left sphenoid ridge meningioma diagnosed by CT scan without use of contrast media in 1974. The tumor was considered inoperable because of its location and her medical condition. In October 1976, she was admitted to the hospital because of increasing but mild confusion, staring spells, and the sudden appearance of right arm paralysis on the day prior to admission. Her medical history was complicated
Cervical Cancer Screening Clinical Practice Guidelines in Oncology
Journal: Journal of the National Comprehensive Cancer Network (2004)

Despite a significant decrease in the incidence and mortality of cervical carcinoma in the United States, 10,520 women are expected to develop the disease in 2004, with 3,900 expected deaths. Because cervical cytology screening is the current method for early detection of this neoplasm, the purpose of the NCCN Cervical Cancer Screening Guidelines is to provide direction for the evaluation and management of cervical cytology. For the most recent version of the guidelines, please visit NCCN.org
METEOROLOGIC FACTORS AND ACUTE RHEUMATISM.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Atlas of Hemodynamics of the Cardiovascular System.
Journal: Annals of Internal Medicine (1963)

about it, and tries to probe the causes of infidelity.A short epilogue entitled "Must Marriage Become Monotonous?" is aimed at couples who have ceased to be sensitive to each other's needs and whose sexual relations have drifted into uninspired habit.Many interesting and obviously worthwhile corrective measures are suggested, and, as it says on the dust jacket, this marriage manual may well be as valuable on a couple's twenty-fifth anniversary as on their wedding night.This reviewer joins Dr. Barnes in recommending "Sexual Responsibility in Marriage" to all married couples and to all physicians who must from time to time provide counsel for husbands and wives.
Response to Letter Regarding Article, “Arterial Pulse Wave Dynamics After Percutaneous Aortic Valve Replacement: Fall in Coronary Diastolic Suction With Increasing Heart Rate as a Basis for Angina Symptoms in Aortic Stenosis”
Authors: Justin E. Davies, Sayan Sen, Chris Broyd, Nearchos Hadjiloizou, John Baksi, Darrel P. Francis, Kim H. Parker, Alun D. Hughes, Rodney A. Foale, Andrew Chukwuemeka, Roberto Casula, Iqbal S. Malik, Ghada W. Mikhail, Jamil Mayet
Journal: Circulation (2012)