tbuckley/cabot-search huggingface dataset:
Clinical Crossroads Update: An 82-Year-Old Woman With Cataracts
Authors: Elliot Davidoff
Journal: JAMA (1997)

<h3>To the Editor.</h3> —In discussion<sup>1</sup>of the follow-up of an 82-Year-old Haitian woman with cataracts that were increasingly impairing her ability to function, I feel that misleading information has been presented that could adversely affect a primary care physician's ability to properly weigh the risks and benefits of cataract surgery on an elderly patient. This could lead to an inappropriate recommendation to withhold or delay needed cataract surgery. Cataract surgery is indicated when a patient has a cataract that is interfering with the individual's ability to function and when the ophthalmic examination reveals that there is potential for visual improvement. If the retina, optic nerve, and neural pathways to the visual cortex are functioning properly, there is a high likelihood that vision will improve following successful cataract surgery. In the case in question, the patient has had delayed return of vision following cataract surgery and appears to be
Atypical Antipsychotic Drugs and Hyperglycemia in Adolescents
Authors: Elizabeth Koller
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A. Medical Schools in the United States
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights from Recent Cancer Literature
Journal: Cancer Research (2014)

Novel Role MDA-9/Syntenin in Glioma Invasion in glioblastoma multiforme is a key mediator of pathogenesis, contributing to poor outcome.Genomic database analysis demonstrated that elevated expression of mda-9/syntenin was correlated with decreased survival.Using gain-of-function and loss-offunction approaches in vitro, Kegelman and colleagues showed that MDA-9/Syntenin altered invasion, migration, anchorage-independent growth, and angiogenesis.MDA-9/Syntenin led to activation of c-Src (SRC), p38 MAPK (MAPK14), and NF-kB (RELA), followed by increased expression of MMP2 and IL-8.In vivo, silencing of MDA-9/Syntenin expression caused decreased tumor size, and tumors displayed a less invasive phenotype.These studies confirm MDA-9/Syntenin as a novel mediator of invasion that may provide a target to treating invasion in glioblastoma.(Image courtesy
THE CLASSIFICATION OF BACTERIA
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunotherapy for Metastatic Cancer
Authors: Samuel Hellman
Journal: JAMA (1994)

Often in medical investigation there is a period of early enthusiasm when the initial discovery is appreciated and the possible applications and implications are considered. When the discovery is a new therapeutic modality, this initial period of great expectation is followed by a greater understanding of both the toxicity of the agent as well as the limitations of the treatment efficacy, leading to some disillusionment. It is only with time, experience, and careful reporting of the complete experience that the new therapy can be evaluated and its importance determined. This has surely been the case with interleukin 2 (IL-2) treatment for cancer. Early reports of the use of IL-2 published by the National Cancer Institute surgery group led by Dr Rosenberg<sup>1,2</sup>generated considerable interest. Much was written in both the medical literature and the lay press following publication of some of the initial responses observed with IL-2 treatment for
Carcinoembryonic Antigen: Synthesis by a Continuous Line of Adenocarcinoma Cells&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Marianne L. Egan, Charles W. Todd
Journal: JNCI Journal of the National Cancer Institute (1972)

A continuous line of colonic adenocarcinoma cells produced carcinoembryonic antigen (CEA). Several times more CEA activity was present in the culture medium in which the cells were grown than could be extracted from the cells themselves after treatment with perchloric acid (PCA). The active material was a molecule stable in 1 M PCA and soluble in 1.25 M (NH4)2SO4. It eluted from a G200 column in the same position as CEA isolated from tumor tissue. Several other cell lines were negative for CEA production except for ME180, a cervical adenocarcinoma cell line.
The Pathology of Articular and Spinal Diseases.
Journal: Annals of Internal Medicine (1950)

This excellent book fills a gap on the shelves which has always been vacant, and one, moreover, of which too many pathologists have been unaware.It is to be hoped that this authoritative description of pathological changes in joints will be widely read; its views are as sound as its allocation of space, which is primarily devoted to the common joint diseases.There are 199 iUustrations, all of them original (nowadays itself original) and that works out to 0 62 illustrations per page of text.They are excellently photo- graphed, well chosen, and well reproduced, and there is, moreover, as far as your reviewer can judge, none of that dubious modern practice of inserting some of the illustrations twice.Each chapter is followed by a brief and select list of references, chosen for their importance rather than because they are by friends of the author, recent, listed by other writers, written in the author's mother tongue, or furnished free by a drug house card- index service.The book starts in orthodox fashion with anatomy and physiology, proceeds with a brief (20-page) review of bone diseases, and then passes on to trauma, osteo-arthritis, gout, specific infections, rheumatic fever, rheumatoid arthritis (51 pages), etc., ending with 80 useful pages on the spine.The changes described in ankylosing spondylitis, based on four autopsies and the literature, are of outstanding interest, since previous descriptions have been very meagre and in some instances based on cases whose nosological status was rather less than doubtful.To-day, when so much is made of the rare extra-articular manifestations of joint disease, when there is such insistence that rheumatoid arthritis is a generalized disease,
Deep-vein thrombosis after hip replacement
Authors: J A McSherry
Journal: BMJ (1978)

provided that there is no special morbidity associated with its use.The experience of Sculco and Ranawat4 with spinal anaesthesia has been encouraging and this technique is now being used in Gartnavel.Our results so far indicate that when spinal anaesthesia is used the operative blood loss and the post- operative DVT rate are both reduced by about 50% compared with general anaesthesia.
Comparative Tumor-Initiating Activity of Complex Mixtures From Environmental Particulate Emissions on SENCAR Mouse Skin&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;,&lt;xref ref-type="fn" rid="fn3"&gt;3&lt;/xref&gt;,&lt;xref ref-type="fn" rid="fn4"&gt;4&lt;/xref&gt;,&lt;xref ref-type="fn" rid="fn5"&gt;5&lt;/xref&gt;
Authors: Stephen Nesnow, Larry L. Triplett, Thomas J. Slaga
Journal: JNCI Journal of the National Cancer Institute (1982)

The value of the SENCAR mouse for testing tumorigenic properties of complex mixtures on mouse skin was studied. Seven complex mixtures were obtained as dichloromethane extracts of collected particulate emissions from three diesel-fueled automobiles, a heavy-duty diesel engine, a nonleaded gasoline-fueled automobile, a coke oven battery, and a roofing tar pot. These emissions were applied topically at multiple doses to both male and female SENCAR mice that were subsequently promoted with 12-0-tetradecanoylphorbol 13-acetate. Two statistical analyses were applied to the data to rank the samples and to provide 95% confidence intervals. One analysis used tumor multiplicity data, applied them to a nonlinear Poisson model, and the second analysis used tumor incidence data and applied them to a log-probil model. Both analyses ranked the complex mixtures in similar order. Benzo[a]pyrene content alone could not account for all the tumorigenic activity in each complex mixture, indicating that other components also contribute to the overall tumorigenic activity.
Enhancement of Pancreatic Carcinogenesis by a Dietary Unsaturated Fat in Rats Treated With Saline or <italic>N</italic>-Nitroso(2-hydroxypropyl)(2-oxopropyl)amine<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>
Authors: Daniel S. Longnecker, B. D. Roebuck, Elna T. Kuhlmann
Journal: JNCI Journal of the National Cancer Institute (1985)

The effect of diets high in an unsaturated fat on the enhancement of pancreatic carcinogenesis in saline-treated rats and in rats treated with N-nitroso(2-hydroxypropyl)(2-oxopropyl)-amine (HPOP) was examined. Young male LEW rats were treated with a single dose of HPOP (160 mg/kg body wt) or saline, fed diets containing 5 or 20% corn oil, and then autopsied 12 months later. The pancreata of H POP-treated rats fed the diet with 5% fat contained multiple foci and nodules of atypical acinar cells (AACN), acinar cell adenomas, and localized carcinomas. Rats fed the diet with 20% fat developed a similar spectrum of pancreatic lesions and also developed carcinomas that showed local invasion or metastasis to regional lymph nodes. The incidence and multiplicity of localized carcinomas was significantly higher in the group that was fed the high-fat diet. HPOP also induced neoplasms in the liver, lungs, and kidneys, but none of these had a higher incidence in the group fed the high-fat diet. Among rats that received no carcinogen, the incidence of AACN was high, but the multiplicity of these lesions was low, an average of three per pancreas in groups fed both levels of fat; however, the average area of AACN transections was larger in the high-fat diet group. One acinar cell adenoma and 1 carcinoma developed in the group of 11 rats fed the 20% corn oil diet, whereas no neoplasms developed in the group of 12 rats fed the 5% corn oil diet. Although the incidence of pancreatic neoplasms is not significantly different in these 2 groups, the data are consistent with the hypothesis that initiated foci are promoted to grow and become neoplasms in the pancreas of rats that are fed diets with a high content of unsaturated fat—as was demonstrated in the HPOP-treated rats.
Lead Poisoning Associated With Use of Traditional Ethnic Remedies—California, 1991-1992
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wiener Klinische Wochenschrift
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Direct Cytogenetic Studies by Needle Aspiration of Burkitt's Lymphoma in Ghana, West Africa
Authors: Robert J. Biggar, M.D., Elaine C. Lee, Francis K. Nkrumah, Jacqueline Whang-Peng
Journal: JNCI Journal of the National Cancer Institute (1981)

With the use of a needle aspiration technique for obtaining tumor material, the direct karyotype of Burkitt's lymphoma cells was examined from 14 Ghanaian patients. The 14q+ chromosome (in addition to other chromosomal abnormalities) was present in 8 (57%) of the 14 patients; 6 of these 8 patients had t(8;14) (q24;q32). One of the remaining 2 patients had a #8 chromosome deleted, whereas the second had 2 normal-appearing #8 chromosomes. Other numerical and structural abnormalities were frequent. No correlation between type or frequency of abnormality and clinical status or survival was found. Within cells of the same tumor aspirate, the karyotype abnormalities were generally similar. In 3 patients, karyotypes from two separate tumor sites (abdomen-bone marrow, 2 cases; right maxilla-left mandible, 1 case) showed identical markers. The same marker was seen in specimens from the initial and second relapse abdominal tumors of 1 patient. The similarity of chromosomal markers from two sites or in serial studies further supports the concept that African Burkitt's lymphoma is a disease of monoclonal origin.
Vertebral Osteomyelitis
Authors: R M Koenker, S A DeLuca
Journal: JAMA (1966)

In a series of 24 patients with proved hematogenous, pyogenic vertebral osteomyelitis, the disease was insidious in onset in 20. Because x-ray findings were inconclusive, vertebral-body biopsy was required for an accurate diagnosis, when the blood culture was negative. Despite the frequent presence of abnormal roentgenographic shadows, drainage was required in only two patients. Exploration for abscess cannot be determined on the basis of roentgenographic findings alone. The frequency of a benign course and failure of spontaneous arthrodesis induced speculation concerning possible attenuation of the virulence of the organism, altered host immunity, or perhaps, with regard to spontaneous fusion, merely a modification of an end point of the pathologic process by antibiotic treatment.
Spleen-Function Study With 1-Mercuri-2-Hydroxypropane Labeled With Mercury 197
Authors: Yen Wang
Journal: JAMA (1965)

A NEW COMPOUND, 1-mercuri-2-hydroxypropane (MHP) labeled with radioactive mercury (<sup>197</sup>Hg), for spleen scanning has been introduced by Wagner's group.<sup>1</sup>This isotopic preparation offers several advantages in being less time-consuming and having less radiation dose over the previous technique using erythrocytes tagged with sodium chromate Cr 51.<sup>2,3</sup>Radioactive-MHP-tagged erythrocytes reach peak activity in the spleen one to three hours after injection. This activity begins to fall fairly rapidly by four to six hours after injection. As a result, the functional state of the spleen or the degree of erythrocytic sequestration can be evaluated at the same time that the scan is done. For spleen scanning, the procedure using radioactive-MHP is much easier to do than the sodium chromate Cr 51-tagged erythrocyte procedure which required heating the erythrocytes for an hour. Using the radioactive-MHP procedure, the erythrocytic sequestration study can be accomplished in three to four hours, while it
Epidermal Carcinogenesis in the Mouse Induced by Applications of 7,12-Dimethylbenz-[&lt;italic&gt;a&lt;/italic&gt;]anthracene Followed by Croton Oil
Journal: JNCI Journal of the National Cancer Institute (1967)

Three applications of 7,12-dimethylbenz[a]anthracene (DMBA) followed by repeated applications of croton oil induced about twice as many papillomas in mouse skin as did a single application of DMBA followed by croton oil. Varying the interval between the 3 applications of DMBA, within the limits of 1 day to 1 month, did not affect the yield of papillomas. The findings suggest that, contrary to earlier reports, the yield of papillomas induced in experiments of this sort varies with the dose of carcinogen. When a high concentration of DMBA was used, the papillomas appeared sooner after the beginning of croton-oil treatment with 3 applications of DMBA than with 1. This effect was lost if a weak solution of DMBA was used, or if the interval between the last application of carcinogen and the first of croton oil was extended to 14 weeks. It is suggested that the DMBA may have the same kind of promoting action as does croton oil.
What is a good doctor and how can we make one?
Journal: BMJ (2002)

cases. 10 The competing demands of general practice must be explicitly addressed if we are to enable the general practitioner to practise psychological medicine effectively. 11 Yet this approach is no different to what is also required for many chronic medical disorders such as diabetes, asthma, and heart disease, for which it has been proved that care in concordance with guidelines requires appreciable reorganisation of medical services. 12 Neither chronic medical nor "psychiatric" disorders can be managed adequately in the current environment of general practice, where the typical patient must be seen in 10-15 minutes or less.The quick visit may work for the patient with a common cold or a single condition, such as well controlled hypertension, but will not suffice for the prevalent and disabling symptoms and disorders comprising psychological medicine.Evidence based treatments exist.Using them in a way that is integrated with general practice will improve our patients' physical health and psychological wellbeing.
Ferroptosis-based nano delivery systems targeted therapy for colorectal cancer: Insights and future perspectives
Authors: Chu Qiao, Haiying Wang, Qiutong Guan, Minjie Wei, Zhenhua Li
Journal: Asian Journal of Pharmaceutical Sciences (2022)

There are limited options for patients who develop liver metastasis from colorectal cancer (CRC), the leading cause of cancer-related mortality worldwide. Emerging evidence has provided insights into iron deficiency and excess in CRC. Ferroptosis is an iron-dependent form of programmed cell death characterized by aberrant iron and lipid metabolism, which play crucial roles in tumorigenesis, tumor progression, and treatment options. A better understanding of the underlying molecular mechanism of ferroptosis has shed light on the current findings of ferroptosis-based nanodrug targeting strategies, such as driving ferroptosis in tumor cells and the tumor microenvironment, emerging combination therapy and against multidrug resistance. Furthermore, this review highlights the challenge and perspective of a ferroptosis-driven nanodrug delivery system for CRC-targeted therapy.
Sacubitril/valsartan and loop diuretic requirement in heart failure with preserved ejection fraction in the <scp>PARAGON‐HF</scp> trial
Authors: Safia Chatur, Brian L. Claggett, Orly Vardeny, Karola Jering, Akshay S. Desai, Marc A. Pfeffer, Martin Lefkowitz, John J.V. McMurray, Scott D. Solomon, Muthiah Vaduganathan
Journal: European Journal of Heart Failure (2022)