tbuckley/cabot-search huggingface dataset:
Pulmonary disease caused by<i>M. malmoense</i>in HIV negative patients: 5‐yr follow-up of patients receiving standardised treatment
Journal: European Respiratory Journal (2003)

The literature concerning the management of pulmonary disease caused by Mycobacterium malmoense consists of retrospective reports on small series of patients. A recent multicentre trial conducted by the British Thoracic Society provided an opportunity to prospectively document the clinical features and response to treatment of this relatively rare but challenging disease in a substantial number of patients. When two positive cultures were confirmed by the Mycobacterium Reference Units for England, Wales, Scotland or Scandinavia, the coordinating physician invited the patient's physician to enrol the patient, who was then treated on a random basis with either rifampicin plus ethambutol or rifampicin, ethambutol and isoniazid for 2 yrs. Clinical, bacteriological and radiological progress were monitored at set intervals for 5 yrs. In over 5 yrs a total of 106 patients were recruited to the study. The mean age was 58 yrs, range 24–89 yrs. A total of 58% were male and just over half previously or at the time of the study had other lung diseases. Sputum was positive on direct smear in 58%. Cavitation was seen on the chest radiographs of 74%, the majority having cavities of ≥2 cm in diameter. Less than half of the patients showed bilateral disease, 26% having involvement of more than three lung zones. Disease was confined to the upper zone(s) in 30%. Other lung diseases were evident in 52%. Although clinical response was judged satisfactory at most reviews (90%), one in three patients died within 5 yrs and &lt;5% were thought to have died primarily because of M. malmoense . There were three failures of treatment and eight relapses after the end of treatment. There was no correlation between failure of treatment/relapse and in vitro resistance. A total of 63 (59%) of patients were alive at 5 yrs, of whom 44 (42% of the total entry) were known to be cured. Pulmonary disease caused by Mycobacterium malmoense is a serious condition that is associated with high morbidity and mortality. The results of standard susceptibility tests do not correlate with the bacteriological response of the disease to chemotherapy. Rifampicin and ethambutol, with or without isoniazid, cured only 42% of patients but were better tolerated than previously described, more complex regimens of equal or lesser efficacy. There is a need for more effective regimens that will reduce mortality and failure of treatment/relapse rates, but, in addition, attention should be directed at improving management of comorbid conditions and improving the general health of the patient.
Covering the uninsured. Interactions among public and private sector strategies
Authors: K. E. Thorpe
Journal: JAMA (1989)

THE MEDICAID program, designed to provide access to health care for the nation's poor, fails to provide coverage for more than 10.9 million individuals with annual income below the federal poverty level.<sup>1</sup>The gaps in coverage of the poor and the inequities of the current categorical eligibility system have focused interest on Medicaid reform. Recent federal initiatives have incrementally expanded Medicaid eligibility, particularly for poor pregnant women and young children. For proponents of more comprehensive Medicaid reform, however, the cost of expanding the program is an important obstacle. The legislative feasibility of any proposal to extend coverage depends critically on the level of new public sector spending required. In previous work, we estimated the fiscal impact of a proposal to expand Medicaid eligibility to cover all persons with annual income below the federal poverty level. This proposal, advanced by the Health Policy Agenda for the American People,<sup>2</sup>would
Continuing education as requirement for medical society membership
Authors: M. Pennington
Journal: JAMA (1970)

During late 1967 and early 1968, the Council on Medical Education of the Oregon Medical Association studied the idea of a continuing-education requirement for membership in the association and brought the following recommendations to the spring meeting of the OMA House of Delegates: (1) that minimum requirements be established for continuing education for physicians of the association; and (2) that an evaluation mechanism be established regarding the quality of continuing education programs and modalities available. After exhaustive testimony by the council and discussion by many physicians throughout the state before the reference committee, the latter recommended approval of the recommendations and the House of Delegates so approved unanimously. The council was thus directed to work out the details of the program and report to the annual meeting. A rough outline, similar to the American Academy of General Practice continuing education program was presented in September 1968, and the OMA authorized
Aging as a Factor in Wound Healing
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiovascular Morbidity and Obstructive Sleep Apnea
Authors: Bruno Cassinat, Jean-Jacques Kiladjian
Journal: New England Journal of Medicine (2014)

correctionIn Patient 1, a 52-year-old woman who had received a diagnosis of essential thrombocythemia in August 2005, interferon alfa was started in October 2005 as first-line therapy and stopped after 36 months owing to a lasting hematologic complete response.The patient was still in complete remission without cytoreductive therapy at the last follow-up visit in September 2013.In this patient, a CALR insertion mutation (p.K385fs*47) was detected in two pretreatment samples and was considerably reduced in profusion in three follow-up samples (Fig. 1).Patient 2, a 48-year-old man who had received a diagnosis of essential thrombocythemia in 2000, was treated with hydroxyurea until January 2010, when he was switched to peginterferon alfa-2a owing to secondary resistance (Fig. 1).Interferon alfa was stopped after 31 months because of a lasting hematologic complete response, and the patient was still in complete remission without cytoreductive therapy in November 2013.In this patient, the CALR mutation was a deletion (p.L367fs*46), which was detected in two samples obtained before interferon alfa therapy and was reduced in two subsequent samples (Fig. 1).Both patients reported moderate fatigue and mood changes, which resolved after discontinuation of interferon alfa.In these patients with essential thrombocythemia and CALR mutations, interferon alfa therapy resulted in a hematologic complete response that was maintained for more than 60 months (in Patient 1) and more than 18 months (in Patient 2) after the discontinuation of interferon alfa, in association with a reduction in the mutant allele burden.These results suggest that CALR-mutated cells can be durably targeted by interferon alfa therapy.
Laboratory control of anticoagulants.
Journal: BMJ (1966)

not cause the damage.Even nitrate-rich spinach, when eaten fresh, is tolerated well by babies, but water rich in nitrate often causes methaemoglobinaemia.In the two cases in which methaemoglobinaemia developed within two hours of the meal it is probable that the raw spinach contained an excess of nitrite, possibly owing to inefficient and too tight storage during transport.The amount of nitrite absorbed cannot be assessed by estimating the methaemoglobin concentration.Aspiration of stomach contents reveals spinach up to eight hours after a meal, and it serves the therapeutic purpose of preventing further absorption of nitrites.The haemoglobin becomes normal 12 to 14 hours later.
Medical news: opportunities and dangers
Authors: A. Soffer
Journal: JAMA (1986)

Science writing is a new discipline and one worthy of respect. It is becoming one of the most important methods of communication to both physicians and laymen. However, this imposes a responsibility on reporters to be aware of the deficiencies in the medical scientific community so that as science writers they are not misguided in the exercise of their profession. A large proportion of medical news aimed at the physician population is a direct result of the science writer's tendency to worship the god of speedy communication. The current fetish is to honor word about the<i>newest</i>drug, the<i>latest</i>device, the most<i>recent</i>transplant experiment. This phenomenon is a tribal practice that has deep roots in journalism. Only recently has there been an awareness that developments in medical science do not have to be covered in the same manner that one would report, for example, a four-alarm fire on
Clinical viral hepatitis B among Minnesota hospital personnel. Results of a ten-year statewide survey
Authors: M. T. Osterholm
Journal: JAMA (1985)

We report a ten-year survey of clinical hepatitis B virus (HBV) infections in Minnesota hospital personnel. Between 1974 and 1983, a total of 561 personnel cases of viral hepatitis were identified. Four hundred twelve cases were diagnosed as type B, with 399 cases (97%) identified as work related. Of the 177 hospitals in the state, only 42 (24%) reported cases during the ten-year period. The highest annual incidence of type B cases was in 1975 (127/100,000 personnel) and decreased to the lowest incidence in 1983 (8/100,000 personnel). The incidence for personnel at hospitals with long-term hemodialysis decreased from 418/100,000 personnel in 1975 to 16/100,000 personnel in 1983, while the incidence for employees in hospitals without hemodialysis decreased from 16 to 5/100,000 personnel for the same time. The decrease in the incidence of hepatitis B in personnel occurred before the use of HBV vaccine. Our findings indicate that HBV seroprevalence studies significantly overestimate the current incidence of HBV infections among personnel in most hospital settings. (<i>JAMA</i>1985;254:3207-3212)
Micturition Syncope
Authors: William L. Proudfit, Mario Enrique Forteza
Journal: New England Journal of Medicine (1959)

INTEREST in syncope of circulatory origin was stimulated by publication in 1935 of Weiss's1 monograph describing various clinical syndromes. Subsequently, the mechanisms of some types of syncope have been clarified. Recently, a group of patients were encountered in whom syncope occurred during or immediately after urination. No reports of this type of syncope have been found.Case ReportsCase 1. A 46-year-old salesman was examined on May 7, 1951, at the Cleveland Clinic. Since the age of 16, he had fainted 6 times at intervals of several years; the last attack had occurred about 3 weeks before examination. The 6 . . .
Prolongation of Life or Prolonging the Act of Dying?
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nutritional assessment
Authors: I. D A Johnston
Journal: Gut (1985)

gastroenterology (once a year) to Progress in . . .and Recent advances in . . .gastroenterology (every two to four years), as well as the free literature reviews provided by at least two drug firms.Clearly it is unnecessary for a gastroenterologist to try to take in all these reviews of essentially the same material by several different reviewers.Good though it is, Current gastroenterology, at about £59, will have a hard time competing.It is a good read, but perhaps it is unnecessary to take it every year.
WASHINGTON NEWS
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CORRECT OFFICIAL INSTRUCTIONS AS TO DISINFECTION WITH SULPHUR.
Journal: JAMA (1890)

The Kentucky State Board of Health has put forth a circular about contagious disease prevention, which is the first, within our knowledge, that instructs the people how to thoroughly disinfect the sick-chamber, after the recovery or death, or removal of the patient. The circular in question is issued with the intent to prevent diphtheria, that disease having been unusually prevalent in many sections of the State. Its teachings with regard to the rigid observance of the known modern requirements as to fumigations with sulphur are much more accurate than the average board of health directions. They, of course, apply to other communicable diseases besides diphtheria. They are in effect the teachings of the report, of three years ago, prepared byDr. G. M. Sternbergand his associates on the special committee of the American Public Health Association. In that report the injunction is frequently given that all fumigations by sulphur
Stunted Growth
Authors: Rebecca Voelker
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Varices of the Upper Esophagus in Superior Vena Caval Obstruction
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A second-opinion program for coronary artery bypass graft surgery
Authors: Sylvain Fribourg
Journal: JAMA (1988)

<h3>To the Editor.</h3> —The study by Graboys et al<sup>1</sup>and the accompanying editorial in the same issue of<i>JAMA</i>by McIntosh<sup>2</sup>do not analyze the reactions and actions of the patient facing a second opinion contradictory to the first opinion. The study's authors write of the difficulties confronting a physician providing a second opinion, which, "to date, have not been resolved." The editorial's author also comments on the difficulties encountered by the physician rendering a second opinion, adding that "this study by Graboys et al should encourage the public to ask more frequently for a second opinion." It has been my practice for years, as a result of observing the bitter trials experienced by some patients receiving contradictory opinions, whenever I see a patient for a second opinion to preface the medical care activity by a discussion with the patient of the potential dilemma to be faced in
Emissions of Arsenic in Sweden and Their Reduction
Authors: Lars Lindau
Journal: Environmental Health Perspectives (1977)

The role of arsenic in Sweden is generally described, including raw materials, exports/imports, products, consumption, etc. An attempt was also made to estimate the transport of arsenic in Sweden. The quantities of arsenic in raw materials, the emissions of arsenic from such processes as copper smelters and chemical industries, and the amounts of products containing arsenic were calculated. The studies show that a copper smelter is the main user of arsenical materials, the very largest emitting source and also the plant which manufacturers most arsenic products. A summary of measurements of arsenic in air, water and soil in Sweden has also been made. The concentrations near a smelter, in the Baltic, in cities and in "clean-air areas" are given. The efforts made to date to reduce the emissions of arsenic and the measures planned for the next few years are described. A reduction has already been achieved and a further rather large decrease will come, especially in arsenic levels in water. The possibilities of minimizing the use of materials and products containing arsenic is also discussed.
Preparation for Marriage.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
La syphilis nerveuse: Etiologie.—Pathogénie.—Prophylaxie.—Traitement. Études cliniques et biologiques.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal