tbuckley/cabot-search huggingface dataset:
New role for Joe Miller
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rising incidence of adenocarcinoma of the esophagus and gastric cardia
Authors: W. J. Blot
Journal: JAMA (1991)

Analyses of cancer incidence data from nine areas of the United States revealed steadily rising rates from 1976 to 1987 of adenocarcinomas of the esophagus and gastric cardia. The increases among men in this period ranged from 4% to 10% per year, and thus exceeded those of any other type of cancer. In contrast, there were relatively stable trends for squamous cell carcinoma of the esophagus and slight declines for adenocarcinoma of more distal portions of the stomach. Adenocarcinomas of the esophagus and gastric cardia disproportionately affected white men and rarely occurred among women. By the mid-1980s. among white men, adenocarcinomas accounted for about one third of all esophageal cancers, while cardia cancers accounted for about one half of all stomach cancers with specified subsites. The rising incidence rates and similar demographic patterns point to the need for investigation into the causes of these poorly understood cancers. (<i>JAMA</i>. 1991;265:1287-1289)
Percutaneous Device Closure of Patent Foramen Ovale for Secondary Stroke Prevention
Authors: Patrick T. O'Gara, Steven R. Messe, E. Murat Tuzcu, Gloria Catha, John C. Ring
Journal: Circulation (2009)

The optimal therapy for prevention of recurrent stroke or transient ischemic attack in patients with cryptogenic stroke and patent foramen ovale has not been defined. Although numerous observational studies have suggested a strong association between patent foramen ovale and cryptogenic stroke, a causal relationship has not been convincingly established for the majority of affected patients. Treatment choices include medical therapy with antiplatelet agents or vitamin K antagonists, percutaneous device closure, or open surgical repair. Whereas suture closure of an incidental patent foramen ovale is performed routinely during the course of an operation undertaken for another indication, primary surgical repair is rarely advocated in the current era. The choice between medical therapy and percutaneous device closure has been the subject of intense debate over the past several years, albeit one that has not been adequately informed by randomized, prospective clinical trial data to permit an objective comparison of the relative safety and efficacy of these respective approaches. Enrollment in clinical trials has lagged considerably despite frequent calls for participation from the US Food and Drug Administration and major professional societies. Completion and peer review of ongoing trials are critical steps to establish an evidence base from which clinicians can make informed decisions regarding the best therapy for individual patients. The present advisory strongly encourages all clinicians involved in the care of appropriate patients with cryptogenic stroke and patent foramen ovale—cardiologists, neurologists, internists, radiologists, and surgeons—to consider referral for enrollment in these landmark trials to expedite their completion and help resolve the uncertainty regarding optimal care for this condition.
Spinal Anesthesia May Not Be Responsible For Backache Following Inguinal Hernia Repair
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Simvastatin as a Treatment for Pulmonary Hypertension Trial
Authors: Martin R. Wilkins, Omar Ali, William Bradlow, John Wharton, Anne Taegtmeyer, Christopher J. Rhodes, Hossein A. Ghofrani, Luke Howard, Petros Nihoyannopoulos, Raad H. Mohiaddin, J. Simon R. Gibbs
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

Rationale: In animal models of pulmonary hypertension, simvastatin has been shown to reduce pulmonary artery pressure and induce regression of associated right ventricular (RV) hypertrophy.Objectives: To assess the therapeutic value of simvastatin in patients with pulmonary arterial hypertension (PAH).Methods: Forty-two patients with PAH were randomized to receive either simvastatin (80 mg/d) or placebo in addition to current care for 6 months, and thereafter offered open-label simvastatin.The primary outcome was change in RV mass, assessed by cardiac magnetic resonance (CMR).Measurements and Main Results: At 6 months, RV mass decreased by 5.2 6 11 g in the statin group (P 5 0.045) and increased 3.9 6 14 g in the placebo group.The treatment effect was 29.1 g (P 5 0.028).N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels decreased significantly in the statin group (275 6 167 fmol/ml; P 5 0.02) but not the placebo group (49 6 224 fmol/ml; P 5 0.43; overall treatment effect 2124 fmol/ml; P 5 0.041).There were no significant changes in other outcome measures (including 6-minute walk test, cardiac index, and circulating cytokines).From 6 to 12 months, both RV mass and NT-proBNP increased toward baseline values in 16 patients on active treatment who continued with simvastatin but remained stable in 18 patients who switched from placebo to simvastatin.Two patients required a reduction in dose but not cessation of simvastatin.Conclusions: Simvastatin added to conventional therapy produces a small and transient early reduction in RV mass and NT-proBNP levels in patients with PAH, but this is not sustained over 12 months.Clinical trial registered with www.clinicaltrials.gov(NCT00180713).
LUNG RESECTION
Authors: H. Souttar
Journal: BMJ (1953)

<h3>Abstract</h3> Neural trajectories constitute propagating sequences of activity that are essential to cognitive representations. Understanding how neural trajectories overcome the disorganizing influence of neural noise in the awake state remains challenging. Theoretical and artificial network models have focused on optimizing the synaptic pathways underlying trajectory propagation. However, in a biophysical network with synaptic plasticity, solely altering synaptic connectivity induces a tight tradeoff between spurious trajectory interruptions and inductions by noise. Formal analysis predicts that separating the inhibitory fluctuations-driven spontaneous activity from the excitatory-driven trajectory propagation is key to reliable triggering and propagation. Amongst biophysical solutions, calcium-activated suprathreshold intrinsic conductances provided the best trajectory reliability by mitigating the reliance of propagation on connectivity. These mechanisms display parametric robustness and generalize to a variety of static and dynamic attractors with uni- and bidirectional propagation. Thus, we provide a unified framework for cognitive-associated neural trajectories robust to neural noise in the awake state.
WHICH COMES FIRST—THE SUCCESS OR THE GOUT?
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HMOs
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transactions of the Kentucky State Medical Society, forty-fifth annual session held at Georgetown, May 9, 10 and 11, 1900.
Journal: JAMA (1900)

The annual Transactions of the Kentucky State Medical Society, containing the papers, minutes, etc. of the meeting held in Georgetown last May, came to hand so much earlier this year than formerly that we unconsciously looked at the title-page to see if it did not bear the date of 1899. We congratulate the members on the radical change in this regard. The book contains some excellent papers, as it naturally must, since Kentucky is noted for having brilliant men in its medical profession. The society is in a prosperous condition, numerically, its membership exceeding 500. The book is a neatly gotten up volume.
Erratum to: The Intensive Care Global Study on Severe Acute Respiratory Infection (IC‑GLOSSARI): a multicenter, multinational, 14-day inception cohort study
Authors: Yasser Sakr, Ricard Ferrer, Konrad Reinhart, Richard Beale, Andrew Rhodes, Rui Moreno, Jean Francois Timsit, Laurent Brochard, B. Taylor Thompson, Ederlon Rezende, Jean Daniel Chiche
Journal: Intensive Care Medicine (2016)
Updated Additional Contributions
Journal: JAMA Pediatrics (2018)

Angela Lumba-Brown, MD; Keith Owen Yeates, PhD; Kelly Sarmiento, MPH; Matthew J. Breiding, PhD; Tamara M. Haegerich, PhD; Gerard A. Gioia, PhD; Michael Turner, MD; Edward C. Benzel, MD; Stacy J. Suskauer, MD; Christopher C. Giza, MD; Madeline Joseph, MD; Catherine Broomand, PhD; Barbara Weissman, MD; Wayne Gordon, PhD; David W. Wright, MD; Rosemarie Scolaro Moser, PhD; Karen McAvoy, PhD; Linda Ewing-Cobbs, PhD; Ann-Christine Duhaime, MD; Margot Putukian, MD; Barbara Holshouser, PhD; David Paulk, EdD; Shari L. Wade, PhD; Stanley A. Herring, MD; Mark Halstead, MD; Heather T. Keenan, MD, PhD; Meeryo Choe, MD; Cindy W. Christian, MD; Kevin Guskiewicz, PhD, ATC; P. B. Raksin, MD; Andrew Gregory, MD; Anne Mucha, PT, DPT; H. Gerry Taylor, PhD; James M. Callahan, MD; John DeWitt, PT, DPT, ATC; Michael W. Collins, PhD; Michael W. Kirkwood, PhD; John Ragheb, MD; Richard G. Ellenbogen, MD; Theodore J. Spinks, MD; Theodore G. Ganiats, MD; Linda J. Sabelhaus, MLS; Katrina Altenhofen, MPH; Rosanne Hoffman, MPH; Tom Getchius, BA; Gary Gronseth, MD; Zoe Donnell, MA; Robert E. O’Connor, MD, MPH; Shelly D. Timmons, MD, PhD
Acta Ophthalmologica, Copenhagen
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myeloproliferative Transition
Authors: M. N. SILVERSTEIN
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 April 1970Myeloproliferative TransitionM. N. SILVERSTEIN, M.D.M. N. SILVERSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-4-600 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I read with great interest the article by Dr. Glaser and Dr. Walker entitled "Transition Among Myeloproliferative Disorders" (Ann Intern Med71:285, 1969). Our group reported on 137 patients with agnogenic myeloid metaplasia (1). We pointed out that 24 of these patients had had previously documented polycythemia vera and that neither the presence of previous polycythemia vera nor the state of the marrow at the time of diagnosis of myeloid metaplasia produced any apparent change in the probability of the patient's survival when compared with patients with idiopathic myeloid metaplasia. It might be of interest to the...References1. SILVERSTEINGOMEZREMINE MMW: Agnogenic myeloid metaplasia. Natural history and treatment. Arch Intern Med (Chicago) 120:546-550, 1967 CrossrefMedlineGoogle Scholar2. SILVERSTEINLINMAN MJ: The causes of death in agnogenic myeloid metaplasia. Proc Staff Mayo Clin 44:36-39, 1969 MedlineGoogle Scholar3. SILVERSTEIN M: Primary or hemorrhagic thrombocythemia. Arch Intern Med (Chicago) 122:18-22, 1968 CrossrefMedlineGoogle Scholar4. SILVERSTEIN M: Myeloproliferative diseases; their shifting spectrum. Postgrad Med 43:167-171, 1968 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Mayo Clinic Rochester, Minn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPhaseoleae 1 April 1970Volume 72, Issue 4Page: 600-600KeywordsBone marrowMyeloproliferative disordersPolycythemia vera Issue Published: 1 April 1970 PDF DownloadLoading ...
Serum uric acid and cholesterol in achievement behavior and motivation. II. The relationship to college attendance, extracurricular and social activities, and vocational aspirations
Authors: S. V. Kasl
Journal: JAMA (1970)

The major findings in this part of the study were (1) Students who are attending college, or are definitely planning to attend, had higher uric acid levels, above and beyond the association with high school grades. (2) There was a positive association between uric acid and activities, irrespective of whether they were the recognized extracurricular activities or the informal social and dating behavior. (3) Subjects with low uric acid levels had more unrealistic vocational expectations and perceptions than did subjects with high uric acid levels. (4) Cholesterol clearly showed a different pattern of associations than did uric acid.
Craniosynostosis in transgenic mice overexpressing Nell-1
Authors: Xinli Zhang, Shun’ichi Kuroda, Dale Carpenter, Ichiro Nishimura, Chia Soo, Rex Moats, Keisuke Iida, Eric Wisner, Fei-Ya Hu, Steve Miao, Steve Beanes, Catherine Dang, Heleni Vastardis, Michael Longaker, Katsuyuki Tanizawa, Norihiro Kanayama, Naoaki Saito, Kang Ting
Journal: Journal of Clinical Investigation (2002)
Multidisciplinary molecular tumour board: a tool to improve clinical practice and selection accrual for clinical trials in cancer patients
Authors: C.D. Rolfo, A. Machado Coelho, P. Van Dam, A. Dendooven, C. Weyn, M. Rasschaert, L. Van Houten, B.X. Trinh, J. Van Meerbeeck, P. Pauwels, M. Peeters
Journal: Annals of Oncology (2016)
Jurassic Park
Authors: Andrew A. Skolnick
Journal: JAMA (1993)

Since Mary Shelley published her classic horror story<i>Frankenstein or The Modern Prometheus</i>in 1818, its motif has been unmercifully recycled—especially by Hollywood film makers who rarely hesitate to cash in on the public's fear of scientists and the unnatural things they do. The book<i>Jurassic Park</i>, by Michael Crichton, MD, and the movie of the same name by Steven Spielberg are the latest version of the horror story, albeit with much more interesting monsters. While Shelley's tale of horror involves a scientist who assembles pieces of human corpses to recreate a man, Crichton's scientist assembles pieces of 100-million-year-old dinosaur DNA to recreate extinct monsters, which also turn on their human creator. If<i>Jurassic Park</i>were just another gory thriller, one might overlook the book's many blatant absurdities, self-contradictions, and falsehoods. But the novel is more than just scary entertainment. It is a morality play about the alleged evils of
SAT0212 Can We Use Enthesis Ultrasound as an Outcome Measure of Disease Activity in Spondyloarthritis? A Study at Achilles Level
Authors: S. Falcao, C. Castillo-Gallego, D. Peiteado, J. Branco, E. Martín Mola, E. de Miguel
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Spondyloarthritis (SpA) is a group of disorders that are characterized by inflammatory involvement of the enthesis and the adjacent bone. Enthesitis is regarded as the primary lesion and is observed in all SpA subtypes, and may sometimes be present for several years as an isolated clinical manifestation. Ultrasound is currently considered a powerful tool to identify entheseal affectation, capable of improving the diagnostic accuracy in SpA. <h3>Objectives</h3> To evaluate the construct validity of the enthesis ultrasound in the assessment of disease activity in SpA. <h3>Methods</h3> A longitudinal Achilles enthesis ultrasound study in patients with early SpA was undertaken. Achilles ultrasound examinations were performed at baseline, six- and twelve-month time periods and compared with clinical outcomes measures collected at basal visit. <h3>Results</h3> Bilateral Achilles enthesis of 146 early SpA patients (68 women) were analysed. Basal mean ± SD (range) BASFI, BASRI-spine, BASDAI, and ASDAS were 2.44±2.05 (0-8), 0.67±0.74 (0-3), 4.60±2.07 (0-9.5), 2.51±1.16 (0-5), respectively. Baseline mean visual analogic scale for pain and patient global disease assessment were 5.15±2.5 (range of 0-10) and 2.98±1.56 (range of 0-7), respectively. Mean erythrocyte sedimentation rate was 15.0±16.99 (0-109) mm/h and C-reactive protein was 8.67±16.98 (1-90) mg/l. At baseline Achilles Doppler signal and ultrasound structure alteration were statistically significantly associated with higher CRP and ESR levels. Patients with basal very high disease activity assessed by ASDAS (&gt;3.5) had significantly higher Achilles total ultrasound score verified at baseline (p=0.04); and ASDAS &lt;1.3 predicted no Doppler signal at six and 12 months. Overall, Achilles total ultrasound score per patient was significantly greater in patients with basal higher levels of CRP (baseline p=0.04; six months p=0.006; twelve months p=0.03) and ESR (baseline p=0.02; six months p=0.04; twelve months p=0.005). Doppler signal at basal visit predicted higher total ultrasound score at six and twelve months. <h3>Conclusions</h3> Doppler ultrasound seems to be an objective outcome in enthesitis that has significant association with other commonly accepted disease activity measures as ESR, CRP and ASDAS. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2674