tbuckley/cabot-search huggingface dataset:
Mediastinal emphysema.
Journal: BMJ (1967)

Leading ArticlesMEDICJON 5small number of potentially curable patients could be detected with some certainty at this stage many others might be spared fruitless further investigation.The standard intravenous pyelogram (I.V.P.) is not adequate to this end, failing to select about half of those with renovascular hypertension.5 11It gives excellent information about important correctable lesions like unilateral hydronephrosis, pyelonephritis, or tuberculosis, but these play only a small part in renal hyper- tension.In cases of unilateral renal ischaemia major structural changes in kidney or ureter may be evident.Attempts to improve the diagnostic value of the I.V.P. have been based on studies of asymmetric patterns in the excretion of contrast medium deriving from the selective sodium and water reabsorption in the ischaemic kidney.12Films taken at minute intervals after the injection of contrast medium show up any delay in the appearance of contrast, and this technique has been of help in some hands.13However, when differences between the two sides are small, perhaps a minute or less, interpretation can be difficult.14Increased density of contrast medium due to marked reabsorption of water in the affected kidney can also cause confusion.To accentuate the asymmetry of contrast density K. Amplatz15 proposed establishing an osmotic diuresis in the course of the I.V.P. by infusion of urea, thus allowing comparison between the rapid wash-out of contrast from the normal kidney with contrast retention in the ischaemic, oliguric kidney.The early reports of this technique of "radiological divided renal-function studies" suggested a much-improved detection rate of renovascular hypertension, with no false-negative results in the sense of failures to select patients improved by surgery, though "pseudo- positive" results to the test were reported." 17M. H. Schreiber and colleagues'8 have recently laid down a range for the normal and shown that the test does not contribute
Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals
Authors: Yang Qiu, Yanpeng Xu, Yao Zhang, Hui Zhou, Yong-Qiang Deng, Xiao-Feng Li, Meng Miao, Qiang Zhang, Bo Zhong, Yuanyang Hu, Fu-Chun Zhang, Ligang Wu, Cheng-Feng Qin, Xi Zhou
Journal: Immunity (2018)

(Immunity 46, 992–1004.e1–e5; June 20, 2017) The authors noticed two errors in the original versions of Figure 1F and Figure 5B of this article. In Figure 1F, the panel for the α-tubulin immunoblot was incorrect. In Figure 5B, the panel for miR-92a Northern blot was incorrect. We have replaced them with the correct panels. The correct versions of Figure 1F and Figure 5B appear below. These errors do not affect any of the conclusions. The raw data files associated with the corrected figures have been deposited in Mendeley (https://data.mendeley.com/datasets/ttbrccmz7j/1). The authors apologize for any inconvenience they have created.Figure 5BVSR-Deficient HEV71 Triggers Antiviral RNAi Response in Human 293T CellsView Large Image Figure ViewerDownload Hi-res image Download (PPT) Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in MammalsQiu et al.ImmunityJune 20, 2017In BriefIt remains unclear if RNAi is an antiviral immunity in mammals. Qiu et al. demonstrate that a human enterovirus deficient in the RNAi suppression activity of 3A protein triggers virus-derived siRNA production, and this virus-induced RNAi response indeed plays antiviral roles in human somatic cells and mice. Full-Text PDF Open Archive
Tropical bacterial pyoderma in Vietnam. An improved therapeutic regimen
Authors: M. R. McMillan
Journal: JAMA (1969)

Fifty marines and navy hospital corpsmen with tropical pyoderma, a variant form of pyoderma, were treated in the hospital for a period of one week.<i>Staphylococcus aureus</i>and β-hemolytic Streptococcus group A, alone or in combination, were the predominant pathogens present in almost every case. Gram-negative bacilli and fungi not further identified were minor contaminants. Effective treatment in all cases consisted of saline dressings, elevation of affected extremities, and phenoxymethyl penicillin potassium, 500 mg four times a day. One third of the patients with staphylococcal infection were infected with penicillin-resistant organisms in vitro. These patients responded well when treatment was changed to oxacillin sodium in the same dose. Healing was complete in a majority of patients at the end of one week and in all by the end of two weeks. There were no significant complications from the regimen.
Lorlatinib Is Active in Drug-Resistant NSCLC
Journal: Cancer Discovery (2016)

Abstract Data from a phase I study indicate that the investigational ALK inhibitor lorlatinib is active in patients with ALK- or ROS1-positive non–small cell lung cancer, including those with brain metastases. Objective responses were seen among patients with known ALK resistance mutations who had relapsed following treatment with other tyrosine kinase inhibitors.
Electrocardiogram Interpretation
Authors: Weldon J. Walker
Journal: JAMA (1973)

<h3>To the Editor.—</h3> The interesting article by Lynch et al, "Hereditary Progressive Atrioventricular Conduction Defect: A New Syndrome?" (225: 1465, 1973), was unfortunately marred by poor electrocardiographic interpretation and labeling. The bottom tracing in Fig 1 was stated to show "atrioventricular dissociation due to complete heart block." Actually, the recorded R-R intervals of the standard 12-lead tracing demonstrated atrial and ventricular rates varying from 75 to 48 beats per minute, with identifiable P-R intervals between 0.32 and 0.38 seconds. This tracing showed first-degree atrioventricular block only. Beneath the tracing is an unidentified rhythm strip with apparent complete atrioventricular block, having a ventricular rate of 38 beats per minute and an atrial rate of 75 beats per minute. Certainly the rhythm strip wasn't a part of this particular tracing; if so, it should have been stated to show intermittent complete atrioventricular block. The bottom tracing in Fig 5 was stated to
Adipose tissue macrophages acquire a pro-inflammatory phenotype which is associated to liver fibrogenesis in an experimental model of NAFLD in mice
Authors: Celia Martínez Sánchez, Octavi Bassegoda, Silvia Ariño Mons, Beatriz Aguilar-Bravo, Elisa Pose, Virginia Hernandez-Gea, Pau Sancho-Bru, Pere Ginès, Isabel Graupera, Mar Coll
Journal: Journal of Hepatology (2020)
Intramural neurofibroma of the trachea treated by multiple stents
Authors: J H Cranshaw, C Morgan, G Knowles, A G Nicholson, P Goldstraw
Journal: Thorax (2001)

The case history is presented of a patient in whom an intramural tracheal neurofibroma developed, causing severe airway stenosis. The patient was treated with multiple stents over a period of 5 years because of progression of the disease and associated airflow limitation. Clinicians should be aware of this rare complication of neurofibromatosis.
Internal Medicine.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Percentage in Table
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMA grams
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase II and Biologic Study of Interferon Alfa, Retinoic Acid, and Cisplatin in Advanced Squamous Skin Cancer
Authors: Dong M. Shin, Bonnie S. Glisson, Fadlo R. Khuri, John L. Clifford, Gary Clayman, Steven E. Benner, Arlene A. Forastiere, Lawrence Ginsberg, Diane Liu, J. Jack Lee, Jeffrey Myers, Helmuth Goepfert, Reuben Lotan, Waun Ki Hong, Scott M. Lippman
Journal: Journal of Clinical Oncology (2002)

PURPOSE: The purpose of this study was to test interferon alfa (IFNα), 13-cis-retinoic acid (13cRA), and cisplatin biochemotherapy in advanced squamous cell carcinoma (SCC) of the skin. PATIENTS AND METHODS: Patients with advanced skin SCC received IFNα (5 × 10 6 IU/m 2 , subcutaneous injection, three times a week), 13cRA (1 mg/kg, orally, daily), and cisplatin (20 mg/m 2 , intravenous injection, weekly) in a phase II trial. The growth inhibition, cell-cycle, and apoptosis activity of these agents was evaluated in two skin SCC cell lines (SRB1-m7 and SRB12-p9). RESULTS: Thirty-nine patients were enrolled. All were assessable for survival, 35 for response and toxicity (median follow-up was 38 months). The overall and complete response rates were 34% and 17%, respectively, with median durations of 9 and 35.4 months, respectively. The response rate was higher in locally advanced (67%) than metastatic (17%) disease (P = .007). Median survival was 14.6 months. One-, 2-, and 5-year survival rate estimates were 58%, 32%, and 21%, respectively. Toxicity included generally mild to moderate fatigue and mucocutaneous dryness, moderate to severe neutropenia (38%), and neutropenic fever (6%). There were no treatment-related deaths. In vitro growth inhibition and apoptosis effects of cisplatin were differential and inversely associated with those of retinoic acid and especially IFNα in two skin SCC lines. CONCLUSION: The rising incidence, morbidity, and mortality of advanced skin SCC are a major challenge for clinical oncologists. Combined 13cRA, IFNα, and cisplatin was clinically active in extensive locally advanced disease. Each agent had independent, non–cross-resistant biologic effects in vitro, which may account for the combination’s clinical activity.
Allergy abstracts
Authors: David Stein &&em, Harold Friedman, Ohio Monroe, Coleman Stamford, Walzer Bridgeport, Berger Freehold, N Cleveland, Bert Kahn, Tex Andre, J Codispoti Suffern, N Robert, Y Lin, New York, N Christopher, Randolph Waterbury
Journal: Journal of Allergy and Clinical Immunology (1988)
Common Patterns of Water and Electrolyte Change in Injury, Surgery and Disease
Authors: Francis D. Moore
Journal: New England Journal of Medicine (1958)

Acute Respiratory Acidosis Clinical setting and appearances. Sudden interference with the patient's effective pulmonary ventilation is the clinical setting for acute respiratory acidosis (Fig. 11). Obstruction of the air passages in wounds or burns of the upper respiratory tract, pulmonary edema, pulmonary infection, atelectasis, pneumothorax, hemothorax and the open chest are all settings in which this can be produced. Poliomyelitis, crippling positions on the operating table, abdominal distention and overdose of opiates may result in acute respiratory acidosis. Severe acidosis can be present even when the patient has normal color and good oxygenation. When ventilation is precarious, respiratory acidosis may . . .
Passage of diphenylhydantoin across the placenta
Authors: F. A. Baughman
Journal: JAMA (1970)

<h3>To the Editor:—</h3> The levels of diphenylhydantoin in the plasma of a young epileptic mother, in cord blood, and in the serum of her healthy newborn son were essentially equal, indicating that diphenylhydantoin freely crosses the placental barrier. The infant's serum levels suggest a first-order disappearance of diphenylhydantoin and a biological half-life of approximately 19 hours. It is known that diphenylhydantoin crosses the placenta but to our knowledge, there have been no definitive studies reporting diphenylhydantoin levels in newborn infants.<sup>1</sup>The current study demonstrates that diphenylhydantoin freely crosses the placenta reaching equilibrium in the maternal and fetal blood. <h3>Methods and Materials.—</h3> A 19-year-old gravida 1, para 0, white woman gave birth to a healthy, 3,075 gm (6 lb 12 1/2 oz) male child at 8:15 p.m., May 12,1969. Diphenylhydantoin, 100 mg four times a day, had been prescribed for her upon the diagnosis of a seizure disorder in November
Journal club
Authors: Fathimath Farah Shiham
Journal: Thorax (2021)

<h3>Objectives</h3> Executive and behavioural changes are well-recognised in classical amyotrophic lateral sclerosis (ALS), indicating a subclinical behavioural-variant frontotemporal dementia (bvFTD) in some patients. Social cognitive deficits in ALS have been recently described and an impairment was identified on a simple Theory of Mind (ToM) test, which assesses the judgement of the preference of another through direction of eye gaze. The present study further delineated this deficit, by distinguishing between Affective and Cognitive subcomponents, and determining the relationship to behavioural change, levels of empathy and self-awareness. <h3>Methods</h3> The Cognitive–Affective Judgement of Preference Test was administered to 33 patients with ALS and 26 controls. Furthermore, a comprehensive neuropsychological battery and detailed behavioural assessment, with measures of empathy and awareness, were included. <h3>Results</h3> Patients with ALS showed a significant impairment in Affective ToM only when compared with healthy controls, with a deficit in 36% of patients; 12% showed an isolated Affective ToM deficit while 24% showed more generic ToM dysfunction. A Cognitive ToM deficit was found in 27% of patients, with 3% showing an isolated Cognitive ToM deficit. The patients with ALS showed reduced empathy (Fantasy scale) and increased behavioural dysfunction with high levels of apathy. In addition, patients with either an Affective and/or Cognitive ToM deficit exhibited poor self-awareness of their performance and abnormalities on verbal fluency, while those with an Affective ToM deficit also displayed higher levels of apathy and a naming deficit. <h3>Conclusions</h3> Dysfunctional ToM is a prominent feature of the cognitive profile of ALS. This specific difficulty in identifying and distinguishing the feelings and thoughts of another from a self-perspective may underpin the social behavioural abnormalities present in some patients with ALS, manifest as apathy and loss of awareness.
Abstract 15923: Dose-dependent Effect of Sevoflurane Postconditioning on Coronary Perfusion Pressure During Early Cardiopulmonary Resuscitation in a Pig Model of Prolonged Cardiac Arrest
Authors: Matthias L Riess, Timothy R Matsuura, Jason A Bartos, Matthew D Olson, Adamantios Tsangaris, Jennifer N Rees, Tom P Aufderheide, Martin Bienengraeber, Robert W Neumar, Demetris Yannopoulos
Journal: Circulation (2015)

Introduction: Pharmacologic postconditioning with the inhaled anesthetic sevoflurane (SEVO) during cardiopulmonary resuscitation (CPR) has been shown to improve outcomes in a porcine model of prolonged cardiac arrest. Hypothesis: We hypothesized that SEVO works in part by improving coronary perfusion pressure (CPP) during CPR. Methods: Following 15 min of untreated ventricular fibrillation (VF), 16 pigs received mechanical CPR for 4 min without (CON) or with low- (2 Vol%) or high-dose (4 Vol%) inhaled SEVO for 3 min. CPP was measured as the difference between mean aortic pressure and right atrial pressure during chest decompression. Results: CPP (mean±SEM in mmHg) at min 3 and 4 of CPR was higher in high-dose SEVO (46±4) than in low-dose SEVO (23±3) or CON (34±4); there was no significant difference between the latter two. Conclusions: Our data show that pharmacologic postconditioning with SEVO resulted in improved CPP during mechanical CPR if a sufficiently high dose is given. Combined with negligible metabolism and fast uptake and washout by ventilation due to its low solubility coefficient, SEVO may be a suitable drug to improve outcomes after cardiac arrest when given short-term during early CPR. If SEVO is associated with enhanced blood flow generation due to its known vasodilatory effect needs to be determined in future studies.
Pet rat harbouring Seoul hantavirus in Sweden, June 2013
Authors: A Lundkvist, J Verner-Carlsson, A Plyusnina, L Forslund, R Feinstein, A Plyusnin
Journal: Eurosurveillance (2013)

We report the first detection of Seoul hantavirus (SEOV) in a pet rat in Sweden. SEOV-specific antibodies were detected in the pet rat blood by focus reduction neutralising test (FRNT), and SEOV RNA in lung tissue was confirmed by reverse transcription-nested polymerase chain reaction (RT-PCR) followed by sequencing. The discovery follows the recent reports of SEOV infected pet rats, as well as associated human cases of severe haemorrhagic fever with renal syndrome (HFRS), in England and Wales.
A Randomized Trial of Arthroscopic Surgery for Osteoarthritis of the Knee
Authors: Alexandra Kirkley, Trevor B. Birmingham, Robert B. Litchfield, J. Robert Giffin, Kevin R. Willits, Cindy J. Wong, Brian G. Feagan, Allan Donner, Sharon H. Griffin, Linda M. D'Ascanio, Janet E. Pope, Peter J. Fowler
Journal: New England Journal of Medicine (2008)

The efficacy of arthroscopic surgery for the treatment of osteoarthritis of the knee is unknown.We conducted a single-center, randomized, controlled trial of arthroscopic surgery in patients with moderate-to-severe osteoarthritis of the knee. Patients were randomly assigned to surgical lavage and arthroscopic débridement together with optimized physical and medical therapy or to treatment with physical and medical therapy alone. The primary outcome was the total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score (range, 0 to 2400; higher scores indicate more severe symptoms) at 2 years of follow-up. Secondary outcomes included the Short Form-36 (SF-36) Physical Component Summary score (range, 0 to 100; higher scores indicate better quality of life).Of the 92 patients assigned to surgery, 6 did not undergo surgery. Of the 86 patients assigned to control treatment, all received only physical and medical therapy. After 2 years, the mean (+/-SD) WOMAC score for the surgery group was 874+/-624, as compared with 897+/-583 for the control group (absolute difference [surgery-group score minus control-group score], -23+/-605; 95% confidence interval [CI], -208 to 161; P=0.22 after adjustment for baseline score and grade of severity). The SF-36 Physical Component Summary scores were 37.0+/-11.4 and 37.2+/-10.6, respectively (absolute difference, -0.2+/-11.1; 95% CI, -3.6 to 3.2; P=0.93). Analyses of WOMAC scores at interim visits and other secondary outcomes also failed to show superiority of surgery.Arthroscopic surgery for osteoarthritis of the knee provides no additional benefit to optimized physical and medical therapy. (ClinicalTrials.gov number, NCT00158431.)
Osteoporosis
Authors: Kristine E. Ensrud, Carolyn J. Crandall
Journal: Annals of Internal Medicine (2018)

Letters20 February 2018OsteoporosisKristine E. Ensrud, MD, MPH and Carolyn J. Crandall, MD, MSKristine E. Ensrud, MD, MPHUniversity of Minnesota, Minneapolis, Minnesota (K.E.E.) and Carolyn J. Crandall, MD, MSUniversity of California, Los Angeles, Los Angeles, California (C.J.C.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0587 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We concur with Dr. Shapses and thank her for her comment. We used the term "recommended dietary allowance" because it was used by the Institute of Medicine in its 2011 report on dietary reference intakes for calcium and vitamin D. It is defined as the average dietary intake required to meet the needs of more than 97% of the population. The values of calcium in milligrams per day noted by Dr. Shapses as "recommended dietary intake" are identical to those that we noted as recommended dietary allowances.We agree with Dr. Shapses' concern that some patients are overzealous ... Author, Article, and Disclosure InformationAffiliations: University of Minnesota, Minneapolis, Minnesota (K.E.E.)University of California, Los Angeles, Los Angeles, California (C.J.C.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=AITC201708010. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoOsteoporosis Kristine E. Ensrud and Carolyn J. Crandall Osteoporosis Sue Shapses Metrics Cited byEffects of Xuling Jiangu Recipe on the Composition of Intestinal Flora and Gene Function in Osteoporosis Model RatsTyloxapol inhibits RANKL-stimulated osteoclastogenesis and ovariectomized-induced bone loss by restraining NF-κB and MAPK activationOsteoking improves OP rat by enhancing HSP90‑β expressionThe Long Non-coding RNA-ORLNC1 Regulates Bone Mass by Directing Mesenchymal Stem Cell FateEffects of parathyroid hormone (1-34) on the regulation of the lysyl oxidase family in ovariectomized mice 20 February 2018Volume 168, Issue 4Page: 306-307KeywordsCalciumDisclosureOsteoporosisRecommended dietary allowanceVitamin D ePublished: 20 February 2018 Issue Published: 20 February 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...