tbuckley/cabot-search huggingface dataset:
356MO Osimertinib adjuvant therapy in patients (pts) with resected EGFR-mutated (EGFRm) NSCLC (ADAURA): Central nervous system (CNS) disease recurrence
Authors: M. Tsuboi, Y-L. Wu, J. He, T. John, C. Grohe, M. Majem, J.W. Goldman, K. Laktionov, S-W. Kim, T. Kato, H.V. Vu, C. Akewanlop, C-J. Yu, F. de Marinis, M. Domine, F.A. Shepherd, C. Yan, A. Atasoy, R. Herbst
Journal: Annals of Oncology (2020)
Human Heredity
Authors: J. F. Hammond
Journal: JAMA (1961)

When a new science develops in the midst of older related sciences, there are apt to be differences of opinion on various problems, perhaps even on fundamental issues. The rapidly growing science of genetics is a case in point with respect to the relative importance in human heredity of genes and environment. Some textbooks and the more popular works on genetics leave the impression that human beings become what their genes and chromosomes make them, that what a person is born with is somehow related to what he later does in life. That idea is true to a certain extent; but when it comes to mean that what a person is born with determines what he can, or will, do later in life, the idea becomes damaging. Fortunately, it can be shown to be unsound, and that has been done in this book. Genes and chromosomes are extremely important, but
Albuminuria and the Nephrotic Syndrome Following Exposure to Mercury and Its Compounds
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Right Ventricular Function After Pulmonary Autograft Replacement of the Aortic Valve
Authors: Gerald S. Carr-White, Mark Kon, T. W. Koh, Sally Glennan, Francis D. Ferdinand, Anthony C. De Souza, John R. Pepper, Dudley J. Pennell, Derek G. Gibson, Magdi H. Yacoub
Journal: Circulation (1999)

Background —The pulmonary autograft operation (the Ross procedure) involves excision of a portion of the right ventricular (RV) outflow tract, prolonged cross-clamp times, and insertion of a pulmonary homograft. There is concern about the effect of such operations on right ventricular function. Methods and Results —Twenty-five patients undergoing either pulmonary autograft or homograft replacement of the aortic valve as part of a prospective randomized trial had echocardiographic RV long-axis measurements performed before surgery and 6 months (range 3 to 12 months) after surgery. In all patients, systolic excursion (SE) and both shortening and lengthening rates (SR and LR, respectively) were reduced postoperatively ( P &lt;0.05) (homografts: SE 1.5±0.4 versus 2.3±0.6 cm, SR 6.8±2.1 versus 9.6±3.1 cm/s, LR 6.0±1.8 versus 8.9±3.0 cm/s; autografts: SE 1.4±0.4 versus 2.2±0.4 cm, SR 5.8±3.0 versus 8.2±3.0 cm/s, LR 5.7±1.9 versus 8.5±3.7 cm/s). There were no differences between the 2 groups. Eighteen patients who had undergone either aortic homograft or pulmonary autograft surgery were studied between 6 and 35 months after surgery. RV volumes were assessed with the use of MRI in addition to echocardiographic RV long-axis measurements. Global volumes were increased to a similar amount in both groups (homografts: end-diastolic volume 145±34 mL, end-systolic volume 78±23 mL; autografts: end-diastolic volume 157±33 mL, end-systolic volume 89±25 mL; P =NS), whereas stroke volumes were maintained in both groups (homografts 67±15 mL, autografts 67±16 mL; P =NS). RV SE was depressed in both groups to a similar degree to that seen with the previous group (homografts 1.5±0.3 cm, autografts 1.4±0.2 cm). Conclusions —Aortic valve replacement with either a pulmonary autograft or an aortic homograft leads to a degree of persistent RV longitudinal dysfunction that is not more pronounced in those undergoing the Ross procedure. The mechanisms and long-term effects of these changes must be further studied.
ESGE News and Upcoming Events September 2018
Journal: Endoscopy (2018)

Registration type Until 30.1.2019 Congress registration Non-member € 350 ESGE/CGS/ES SGS (Czech and Slovak societies) members € 200 ESGENA member/fellow in training* € 130 Academic Skills Course Non-member € 130 ESGE/CGS/ES SGS/ESGENA/fellow in training* € 50 Hands-on training (price per session) Non-member € 100 ESGE/CGS/ES SGS/ESGENA**/fellow in training* € 70 *35 years old or younger **Nurse Endoscopists
Sodium cromoglycate in chronic asthma.
Journal: BMJ (1976)

A long-term double-blind trial of sodium cromoglycate (SCG) with and without isoprenaline, with a placebo control, was undertaken in Edinburgh to a similar design as a previously reported trial in London. The results from the two centres were compared and combined. In Edinburgh 41 patients were studied for 36 weeks and 40 for 52 weeks and in the combined series 121 were studied for 36 weeks and 114 for 52 weeks. In the second year 14 patients were followed-up in Edinburgh and 27 in London. The two SCG regimens were superior overall to placebo both in the Edinburgh and London patients. SCG was effective in similar proportions of patients with extrinsic and intrinsic asthma. In the second year the effectiveness of SCG was further tested by randomly allocating half the patients to a placebo. Some patients derived a continuing benefit from SCG, but its continued use did not appear to be necessary for others, whose progress on placebo was satisfactory.
PLoS Medicine Issue Image | Vol. 13(10) October 2016
Journal: PLoS Medicine (2016)

In this month's Editorial Chris Beyrer and colleagues reflect on an underappreciated trend in multiple African, Asian, and Caribbean settings, where the provision of HIV and other essential health services for sexual and gender minorities are expanding despite challenging legal and social environments. The authors argue that while the legal, human rights, and LGBT advocacy communities work to advance structural reforms, such as overturning sodomy statutes, community-based clinical and service providers have vital roles to play in the realization of more immediate rights and benefits—including the right to dignity, safety, and equitable access to services in health care settings. Image Credit: Vinayak Das, Flickr
Would Health Care Reform Be Easier With a Single-Payer System?
Authors: Jonathan Oberlander
Journal: Annals of Internal Medicine (2009)

Letters1 September 2009Would Health Care Reform Be Easier With a Single-Payer System?Jonathan Oberlander, PhD, Theodore Marmor, PhD, and Joseph White, PhDJonathan Oberlander, PhDFrom University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Yale School of Management, New Haven, CT 06520; and Case Western Reserve University, Cleveland, OH 44106.Search for more papers by this author, Theodore Marmor, PhDFrom University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Yale School of Management, New Haven, CT 06520; and Case Western Reserve University, Cleveland, OH 44106.Search for more papers by this author, and Joseph White, PhDFrom University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Yale School of Management, New Haven, CT 06520; and Case Western Reserve University, Cleveland, OH 44106.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-5-200909010-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Dr. Roland that a system of Medicare for all would reduce fragmentation in the U.S. health care system and achieve sizable savings. A single-payer system, however, is not necessary to gain much of those savings. Costs can be controlled with multiple payers—if payment policies are coordinated and systemwide spending targets are set. However, if we keep our multiple-payer system, these payers will need much more stringent regulation than most advocates of preserving our current private insurers seem to be contemplating. Furthermore, having a publicly sponsored public plan to compete with private insurers could aid cost ... Author, Article, and Disclosure InformationAffiliations: From University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Yale School of Management, New Haven, CT 06520; and Case Western Reserve University, Cleveland, OH 44106.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Obama Administration's Options for Health Care Cost Control: Hope Versus Reality Theodore Marmor , Jonathan Oberlander , and Joseph White Would Health Care Reform Be Easier With a Single-Payer System? Aaron M. Roland Metrics 1 September 2009Volume 151, Issue 5Page: 365-366KeywordsConflicts of interestHealth careMedicare ePublished: 1 September 2009 Issue Published: 1 September 2009 CopyrightCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Inhalation Exposure of Animals
Authors: Robert F. Phalen
Journal: Environmental Health Perspectives (1976)

Relative advantages and disadvantages and important design criteria for various exposure methods are presented. Five types of exposures are discussed: whole-body chambers, head-only exposures, nose or mouth-only methods, lung-only exposures, and partial-lung exposures. Design considerations covered include: air cleaning and conditioning; construction materials; losses of exposure materials; evenness of exposure; sampling biases; animal observation and care; noise and vibration control, safe exhausts, chamber loading, reliability, pressure fluctuations; neck seals, masks, animal restraint methods; and animal comfort. Ethical considerations in use of animals in inhalation experiments are also discussed.
LAW AND MEDICINE
Authors: H. N. Morse
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outcome in adolescent and young adult (AYA) patients compared with younger patients treated for high-risk B-precursor acute lymphoblastic leukemia (HR-ALL): A report from the Children’s Oncology Group study AALL0232.
Authors: Eric Larsen, Elizabeth A. Raetz, Naomi Joan Winick, Wanda L. Salzer, James B. Nachman, Meenakshi Devidas, Stephen Hunger, William L. Carroll
Journal: Journal of Clinical Oncology (2012)

CRA9508 Background: Historically, AYA patients (&gt;16yrs of age) with HR-ALL have an inferior outcome compared to HR-ALL patients 1-15 yrs old, due to increased rates of both relapse and toxicity. Methods: AALL0232 was a phase III randomized trial for patients 1-30 years of age with newly diagnosed B-precursor HR-ALL that utilized a 2 x 2 factorial design with an augmented intensity Berlin-Frankfurt-Münster (BFM) backbone. Patients were randomized to receive dexamethasone versus prednisone during Induction and high dose methotrexate versus escalating Capizzi methotrexate during Interim Maintenance I. A total of 2,574 eligible, evaluable, non-Down Syndrome, non-very high risk patients were randomized between January 2004 and January 2011. AYA patients comprised 20% of this group (n=501; 16-21 yrs: 466 and 22-30 yrs: 35). Results: The 5-yr event-free survival (EFS) and overall survival (OS) rates were 68.0% and 79.8% for AYA patients compared to 80.9% and 88.4% for younger patients (p&lt;0.0001). The 5-yr cumulative incidence of relapse was 21.3% for AYA patients and 13.4% for younger patients (p=0.0018), largely due to higher rate of marrow relapse (15.2% vs. 9.0%; p&lt;0.0007) and not CNS relapse (5.2% vs. 3.7%; p=0.5776). In addition, fewer AYA patients achieved remission, defined as &lt;5% marrow blasts at end induction (97.2% vs. 98.8%; p=0.0134). There was no significant difference in induction mortality between AYA and younger patients, 2.4% vs. 1.8% (p=0.36). However post-induction remission deaths were significantly higher in AYA compared with younger patients, 5.5% vs. 2.1% at 5 years (p&lt;0.0001). Conclusions: This is the largest cohort of AYA ALL patients presented to date and confirms high cure rates for AYA patients treated on pediatric ALL trials. AYA HR-ALL patients had lower EFS and OS compared to younger patients, primarily attributable to both higher rates of marrow relapses and remission deaths. Effective strategies to improve the outcome of AYA patients with HR-ALL should be aimed at both furthering leukemia eradication and lowering toxicity of therapy for this patient population.
Reproductive Ethics
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapeutic Exercise.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The family in crisis. A case study of overwhelming illness and stress
Authors: G. L. Rainsford
Journal: JAMA (1981)

During a period of 7 1/2 years, one family encountered life-threatening illness, psychiatric disability, juvenile delinquency, and multiple episodes of trauma, infection, and surgery. Cancer developed in three of the seven children, the mother had five suicide attempts, and the only daughter had a pregnancy out of wedlock with complications during labor and delivery. Chronologically, the stressful events show patterns of interaction and recurring dysfunction between members of the family. Options for the physician caring for such a family are limited. Early recognition of the family dynamics can help the physician set realistic goals and anticipate recurring crises. (<i>JAMA</i>1981;246:60-63)
CONGENITAL MYATONIA.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incidence and severity of prostate cancer in 375 hypogonadal men treated with testosterone undecanoate injections (TU) for up to 10 years and 296 untreated hypogonadal controls.
Authors: Ahmad Haider, Karim Sultan Haider
Journal: Journal of Clinical Oncology (2016)

e16563 Background: Testosterone therapy (TTh) in elderly men is still associated with concerns regarding prostate cancer (PCa). In this study, incidence of PCa in hypogonadal men on long-term treatment with TU in comparison to an untreated hypogonadal control group (CTRL) was assessed. Methods: In an ongoing, cumulative registry study, 375 men (age range: 33-70) with total testosterone (T) ≤ 12.1 nmol/L in the presence of symptoms received TU 1000 mg every 12 weeks following an initial interval of 6 weeks for up to 8 years. 296 hypogonadal men (age range: 57-74) decided against TTh, mainly due to financial reasons. Prostate volume (PV) and PSA were measured and digital rectal examination (DRE)/ transrectal ultrasound (TRUS) performed before treatment initiation and then regularly every 3-6 months. Biopsies were performed when indicated according to EAU guidelines. Results: In T-treated patients, 8 men (2.1%) were diagnosed with PCa. In the control group, 12 (4.1%) were diagnosed with PCa. The incidence per 10,000 years was 32 in the T group and 64 in CTRL. The mean baseline age of PCa patients was 65 years in both groups. All patients underwent radical prostatectomy. In the T group, all patients had a Gleason score ≤ 6 and a predominant Gleason score of 3 in all patients. Tumor grade was G2 in all 8 (100%), tumor stage T2a in 6 (75%) and T2b in 2 (25%) patients. Regional lymph nodes, distant metastases and surgical margin were negative (N0, M0, R0) in all 8 men. In CTRL, Gleason score was > 6 in all 12 patients. Three men had a predominant Gleason score of 3, 8 had 4, and 1 had 5. Tumor grade was G2 in 5 (41.7%) and G3 in 7 (58.3%) patients, tumor stage T2b in 1 (8.3%), T2c in 1 (8.3%), T3b in 4 (33.3%) and T3c in 6 (50%) patients. 7 patients had positive lymph nodes and 7 patients had a positive surgical margin. Conclusions: Long-term treatment with TU in hypogonadal men undergoing regular monitoring according to EAU guidelines does not increase the incidence of PCa in comparison to an untreated hypogonadal CTRL group. PCa was more severe in the CTRL group.
Survival after resection of perihilar cholangiocarcinoma—development and external validation of a prognostic nomogram
Authors: B. Groot Koerkamp, J.K. Wiggers, M. Gonen, A. Doussot, P.J. Allen, M.G.H. Besselink, L.H. Blumgart, O.R.C. Busch, M.I. D'Angelica, R.P. DeMatteo, D.J. Gouma, T.P. Kingham, T.M. van Gulik, W.R. Jarnagin
Journal: Annals of Oncology (2016)
Microfiltration Method for Quantitative Study of Fibrous Particles in Biological Specimens
Authors: J. Bignon, P. Sebastien, M. C. Jaurand, B. Hem
Journal: Environmental Health Perspectives (1974)

Counting coated and uncoated inorganic fibers in sputum has been used to investigate the level of environmental or occupational asbestos exposure and the concentration of fibrous dusts in human lung.Inorganic fibers ini sputum were counted by light microscopy after chemical digestion and microfiltration processing.The same method was used for processing gastric juice and lung tissue.There were no ferruginous bodies (FB) in sputum from 49 patients without any asbestos exposure.The study of sputum from 125 patoients with various asbestos exposure pointed out a high cor- relation between the number of FB in sputum and the level of asbestos exposure.These 125 patients were classified into three groups according to the type of their asbestos occupational hazard: group I, raw asbestos workers; group II, workers manufacturing asbestos products; group III, workers with mixed indlustrial dust exposure.For these three groups, the mean number of FB in sputum was 100, 10, and 1, respectively.The comparison of the FB content of sputum and lung parenchyma showed the absence of FB in sputum when the concentration of FB in lung parenchyma was under 1000/cm3 of lung parenchyma; above this concentration the number of FB in sputum was in good correlation with fiber concentration in lung parenchyma.A preliminary study with the use of gastric juice show- ed that gastric juice is a less sensitive sample for evaluating fiber concentration in lung.The microfiltration method for the counting of uncoated fibers gave results as accurate as those in the centrifugation method.