tbuckley/cabot-search huggingface dataset:
TCT-234 A New Paradigm in the Diagnosis and Treatment of Coronary Artery Disease: A Real-World “CTA First” Approach Reduces Diagnostic Invasive Coronary Angiography and Increases Cath Lab Efficiency
Authors: Shayan Nabavi Nouri, Samuel Wietschner, Justin Ratcliffe, Pankaj Khullar, Matthew Erickson, Amisha Patel, GraceAnn Kinsale, Salvatore Puma, Joseph Puma, Philip Green
Journal: Journal of the American College of Cardiology (2023)
TCT-154 The Impact of Severe Ventricular Remodeling on Quality-of-Life Outcomes After Transcatheter Aortic Valve Replacement
Authors: Pavan Reddy, Ilan Merdler, Matteo Cellamare, Itsik Ben-Dor, Lowell Satler, Toby Rogers, William Weintraub, Ron Waksman
Journal: Journal of the American College of Cardiology (2023)
TCT-168 Clinical Significance of Insulin- and Noninsulin-Dependent Diabetes in Patients Undergoing Percutaneous Revascularization of the Left Main Coronary Artery
Authors: Anastasios Roumeliotis, Samantha Sartori, David Power, Emmanouil Vavouranakis, Konstantinos Tsioufis, Davide Cao, Evangelos Oikonomou, Johny Nicolas, Kenneth Smith, Joseph Sweeny, Samin Sharma, Annapoorna Kini, Roxana Mehran, George Dangas
Journal: Journal of the American College of Cardiology (2023)
TCT-241 Clinical Characteristics and Outcomes of Impella-Supported High-Risk PCI in Patients Turned Down for Coronary Artery Bypass Graft Surgery: Insights From the cVAD PROTECT III Study
Authors: Batla Falah, Behnam Tehrani, Yiran Zhang, Arsalan Abu-Much, David Cohen, Bjorn Redfors, Deepak Acharya, Samer Garas, Suzanne Baron, Babar Basir, Aditya Bharadwaj, Alejandro Lemor, Alexander Truesdell, William O’Neill, Wayne Batchelor
Journal: Journal of the American College of Cardiology (2023)
TCT-222 Impact of Peripheral Arterial Disease Among Patients Hospitalized for ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: A U.S. Population-Based Cohort Study
Authors: Bruce Adrian Casipit, Yajur Arya, Arshi Syal, Abiodun Idowu, Carlo Casipit, John Malin, Avica Atri
Journal: Journal of the American College of Cardiology (2023)
TCT-231 Clinical Outcomes in Valve-in-Valve Transcatheter Aortic Valve Replacement Are Comparable to Native Valve Transcatheter Aortic Valve Replacement
Authors: Kimberley Hemelrijk, Astrid van Nieuwkerk, Jessica Roa-Garrido, Didier Tchetche, Marco Barbanti, Ran Kornowski, Azeem Latib, Augusto D’Onofrio, Flavio Ribichini, Vicente Mainar Tello, Nicolas Dumonteil, Alexandre Abizaid, Samantha Sartori, Paola D’Errigo, Giuseppe Tarantini, Mattia Lunardi, Katia Orvin, Matteo Pagnesi, George Dangas, Roxana Mehran, Fabio Brito, Ronak Delewi
Journal: Journal of the American College of Cardiology (2023)
TCT-210 Long-Term Safety and Efficacy of Endovascular Ultrasound Renal Denervation in Resistant Hypertension: 8-Year Results From the ACHIEVE Study
Authors: Victor Zeijen, Sebastian Volz, Thomas Zeller, Felix Mahfoud, Michael Böhm, Karl-Heinz Kuck, Bert Andersson, Horst Sievert, Philipp Kahlert, Mattie Lenzen, Isabella Kardys, Joost Daemen
Journal: Journal of the American College of Cardiology (2023)
TCT-141 Preliminary Results of the Resorbable Magnesium Scaffold (Magmaris) in Long and Multivessel Lesions: Data From the IT-Masters Registry
Authors: Stefano Galli, Domenico Tavella, Marco Sesana, Ferdinando Varbella, Chiara Bernelli, Salvatore Saccà, Massimo Leoncini, Dario Buccheri, Francesco Pisano, Chiara Fraccaro, Gabriele Tumminello, Angelo Leone, Alfredo Marchese, Giuseppe Tarantini
Journal: Journal of the American College of Cardiology (2023)
TCT-143 Prognostic Implications of Anemia in Impella-Supported HRPCI: Insights From the cVAD PROTECT III Study
Authors: Batla Falah, Bjorn Redfors, Yiran Zhang, Julia Thompson, Arsalan Abu-Much, Aditya Bharadwaj, Babar Basir, Rajan Patel, Wayne Batchelor, William O’Neill
Journal: Journal of the American College of Cardiology (2023)
TCT-243 Early Risk of Major Adverse Limb Events Following Lower Extremity Revascularization in the VOYAGER-PAD Trial
Authors: R. Kevin Rogers, Manesh Patel, Mark Nehler, Sonia Anand, Connie Hess, Judith Hsia, Michael Szarek, Jerrod Nelms, Eva Muehlhofer, Lloyd Haskell, Scott Berkowitz, Marc Bonaca
Journal: Journal of the American College of Cardiology (2023)
TCT-160 Comparative Effectiveness of Moderate-Intensity Statin With Ezetimibe Combination Therapy Versus High-Intensity Statin Monotherapy After Percutaneous Coronary Intervention: A Nationwide Cohort Study
Authors: Ji-Yong Jang, Seonji Kim, Jaehyeong Cho, Seng Chan You, Jung-Sun Kim
Journal: Journal of the American College of Cardiology (2023)
TCT-258 Personalized, CT-Guided Antithrombotic Therapy Versus Lifelong Single Antiplatelet Therapy to Reduce Thromboembolic and Bleeding Events in Nonatrial Patients After Transcatheter Aortic Valve Replacement
Authors: Daniel Overduin, Dirk Jan van Ginkel, Ronak Delewi, Ricardo Budde, Vera Deneer, Manish Motwani, Jurrien Ten Berg
Journal: Journal of the American College of Cardiology (2023)
TCT-120 The Impact of Age in Patients Undergoing Impella-Assisted High-Risk Percutaneous Coronary Intervention: Age Is Not Just a Number
Authors: Md Bhuiyan, Tia Bimal, Faraz Badar, Joanna Fishbein, Juby Roy, Janta Ukrani, Puneet Gandotra, Samy Selim, Lawrence Ong, Luis Gruberg
Journal: Journal of the American College of Cardiology (2023)
TCT-242 "Elective" Catheter-Directed Therapies in Patients With Intermediate-High Risk Pulmonary Embolism With Unfavorable Clinical Parameters Assessed by a PERT
Authors: Ignacio Cigalini, Martin Najenson, Camila Petry, José Fedele, Carina Gumpel, Maria Cecilia Depaoli, Higinio Balparda, Marcelo Cardona, David Polillo, Sebastián Benitez, Diego Freytes, Germán Arce, Rodolfo Navarrete, Claudio Cigalini
Journal: Journal of the American College of Cardiology (2023)
TCT-151 Diagnostic Accuracy of Murray Law–Based Quantitative Flow Ratio in Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement
Authors: Yuta Fukuishi, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Takashi Hiromasa, Tomoyo Hamana, Satoru Sasaki, Hiroyuki Fujii, Yuto Osumi, Seigo Iwane, Tetsuya Yamamoto, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Ken-ichi Hirata
Journal: Journal of the American College of Cardiology (2023)
TCT-250 Transradial Versus Transfemoral Access for Bifurcation Percutaneous Coronary Intervention Using Second-Generation Drug-Eluting Stent
Authors: Jung-Hee Lee, Jun-Won Lee, Young Jin Youn, Ho Sung Jeon, Sung Gyun Ahn, Junghan Yoon
Journal: Journal of the American College of Cardiology (2023)
TCT-226 Impact of Platelet Reactivity on Clinical Outcomes After Drug-Eluting Stent Implantation in East Asian Patients According to the Presence or Absence of Chronic Total Occlusion: Analysis From PTRG-DES Registry
Authors: Donghoon Han, Min-Kyung Kang, Ae-Young Her, Yong Hoon Kim
Journal: Journal of the American College of Cardiology (2023)
TCT-206 Prediction of the Individual Rate of Progression of Aortic Stenosis and Its Association With Clinical Outcomes
Authors: Constantijn Venema, Kees van Bergeijk, Demetra Hadjicharalambous, Theodora Andreou, Jasper Tromp, Jan Krikken, Hindrik van der Werf, A. Van den Heuvel, Yvonne Douglas, Erik Lipsic, Adriaan Voors, Joanna Wykrzykowska
Journal: Journal of the American College of Cardiology (2023)
TCT-145 Relationship Between Preprocedural Blood Pressure and Outcomes in Patients Undergoing Impella-Supported High-Risk PCI: Insights From the cVAD PROTECT III Study
Authors: Guillaume Bonnet, Karl-Philipp Rommel, Batla Falah, Alexandra Lansky, Yiran Zhang, Michael Schonning, Bjorn Redfors, Daniel Burkhoff, David Cohen, Rajan Patel, Babar Basir, William O’Neill, Juan Granada
Journal: Journal of the American College of Cardiology (2023)
TCT-110 Trends in IVUS Utilization for PCI After Smart App Implementation in a Large-Volume Referral Center
Authors: Amit Hooda, Andriy Vengrenyuk, Shingo Minatoguchi, Keisuke Yasumura, Vishal Dhulipala, Derek Pineda, Anoop Koshy, Yuliya Vengrenyuk, Annapoorna Kini
Journal: Journal of the American College of Cardiology (2023)
TCT-232 Percutaneous Coronary Intervention for Left Main Disease in High Bleeding Risk: Outcomes From a Subanalysis of the Delta 2 Registry
Authors: Giulia Botti, Francesco Joannes Federico, Emanuele Meliga, Joost Daemen, Fabrizio D'Ascenzo, Davide Capodanno, Didier Tchetche, Nicolas Van Mieghem, Sunao Nakamura, Corrado Tamburino, Roxana Mehran, Matteo Montorfano, Alaide Chieffo
Journal: Journal of the American College of Cardiology (2023)
TCT-260 Tricuspid Regurgitation and Heart Failure: The Fate of Treated Versus Untreated in the Percutaneous Era—What Is Clear Now?
Authors: Edoardo Zancanaro, Maria Rita Romeo, Andreina D’Agostino, Annalisa Nardone, Teresa Caputo, Nicolò Azzola Guicciardi, Massimiliano Mariani, Sergio Berti
Journal: Journal of the American College of Cardiology (2023)
TCT-189 Prognostic Value of Left Atrial Reservoir Strain and Relative Apical Sparing in Significant Aortic Stenosis: An Asian Cohort Study
Authors: Chung-Yen Lee, Chieh-Mei Tsai, Chi-Ching Huang, Alexander Te-Wei Shieh, Masaaki Takeuchi, Li-Tan Yang
Journal: Journal of the American College of Cardiology (2023)
TCT-128 Treatment of Coronary Artery Disease With Sirolimus-Versus Paclitaxel-Coated Balloons
Authors: Mehdi Madanchi, Adrian Attinger-Toller, Giacomo Maria Cioffi, Eleonora Gnan, Varis Gjergjizi, Yuan Zhi, Irena Majcen, Lynn Benz, Matthias Bossard, Florim Cuculi
Journal: Journal of the American College of Cardiology (2023)
TCT-106 Cost-Effectiveness of Intravascular Imaging–Guided Complex PCI: Prespecified Analysis of RENOVATE-COMPLEX-PCI Trial
Authors: Joo Myung Lee, David Hong, Jin Lee, Hankil Lee, Juhee Cho, Eliseo Guallar, Ki Hong Choi, Seung Hun Lee, Doosup Shin, Jonng-Young Lee, Seung-Jae Lee, Sang Yeub Lee, Sang Min Kim, Kyeong Ho Yun, Jae Young Cho, Chan Joon Kim, Hyo-Suk Ahn, Chang-Wook Nam, Hyuck-Jun Yoon, Yonghwan Park, Wang Soo Lee, Taek Kyu Park, Jeong Hoon Yang, Seung-Hyuck Choi, Hyeon-Cheol Gwon, Young Bin Song, Joo-Yong Hahn, Danbee Kang
Journal: Journal of the American College of Cardiology (2023)
TCT-248 Assessment of Coronary Cannulation, Commissure and Coronary Alignment Post-TAVR With the New Supra-Annular, Self-Expanding Evolut FX System
Authors: Guilherme Attizzani, Shayef Gabasha, Steven Filby, Luis Augusto Palma Dallan, Anene Ukaigwe, Yakov Elgudin, Gregory Rushing, Marc Pelletier, Christian Baeza, Sung-Han Yoon
Journal: Journal of the American College of Cardiology (2023)
Sequential CD19 and CD22 chimeric antigen receptor T-cell therapy for childhood refractory or relapsed B-cell acute lymphocytic leukaemia: a single-arm, phase 2 study
Authors: Jing Pan, Kaiting Tang, Yuechen Luo, Samuel Seery, Yue Tan, Biping Deng, Feng Liu, Xiuwen Xu, Zhuojun Ling, Weiliang Song, Jinlong Xu, Jiajia Duan, Zelin Wang, Chunyu Li, Kai Wang, Yibing Zhang, Xinjian Yu, Qinlong Zheng, Liping Zhao, Jiecheng Zhang, Alex H Chang, Xiaoming Feng
Journal: The Lancet Oncology (2023)
Rusfertide for the treatment of iron overload in HFE-related haemochromatosis: an open-label, multicentre, proof-of-concept phase 2 trial
Authors: Kris V Kowdley, Nishit B Modi, Kevork Peltekian, John M Vierling, Christopher Ferris, Frank H Valone, Suneel Gupta
Journal: The Lancet. Gastroenterology & hepatology (2023)
Once-weekly insulin icodec versus once-daily insulin degludec as part of a basal-bolus regimen in individuals with type 1 diabetes (ONWARDS 6): a phase 3a, randomised, open-label, treat-to-target trial
Authors: David Russell-Jones, Tetsuya Babazono, Roman Cailleteau, Susanne Engberg, Concetta Irace, Maiken Ina Siegismund Kjaersgaard, Chantal Mathieu, Julio Rosenstock, Vincent Woo, David C Klonoff
Journal: The Lancet (2023)

BackgroundONWARDS 6 compared the efficacy and safety of once-weekly subcutaneous insulin icodec (icodec) and once-daily insulin degludec (degludec) in adults with type 1 diabetes.MethodsThis 52-week (26-week main phase plus a 26-week safety extension), randomised, open-label, treat-to-target, phase 3a trial was done at 99 sites across 12 countries. Adults with type 1 diabetes (glycated haemoglobin [HbA1c] <10·0% [86 mmol/mol]) were randomly assigned (1:1) to once-weekly icodec or once-daily degludec, both in combination with insulin aspart (two or more daily injections). The primary endpoint was change in HbA1c from baseline to week 26, tested for non-inferiority (0·3 percentage point margin) in all randomly assigned participants. This trial is registered with ClinicalTrials.gov, NCT04848480, and is now complete.FindingsBetween April 30 and Oct 15, 2021, of 655 participants screened, 582 participants were randomly assigned to icodec (n=290) or degludec (n=292). At week 26, from baseline values of 7·59% (icodec) and 7·63% (degludec), estimated mean changes in HbA1c were −0·47 percentage points and −0·51 percentage points, respectively (estimated treatment difference 0·05 percentage points [95% CI −0·13 to 0·23]), confirming non-inferiority of icodec to degludec (p=0·0065). Overall rate of combined clinically significant or severe hypoglycaemia (baseline to week 26) was statistically significantly higher with icodec than degludec (19·9 vs 10·4 events per patient-year of exposure; estimated rate ratio 1·9 [95% CI 1·5 to 2·3]; p<0·0001). The rate was also statistically significantly higher with icodec than degludec when evaluated over 57 weeks (52 weeks plus a 5-week follow-up period). 39 serious adverse events were reported in 24 (8%) participants receiving icodec, and 25 serious adverse events were reported in 20 (7%) participants receiving degludec. One participant in the icodec group died; this was judged unlikely to be due to the trial product.InterpretationIn adults with type 1 diabetes, once-weekly icodec showed non-inferiority to once-daily degludec in HbA1c reduction at week 26, with statistically significantly higher rates of combined clinically significant or severe hypoglycaemia. For icodec, time below 3·0 mmol/L (<54 mg/dL) was at the threshold of the internationally recommended target (<1%) during weeks 22–26 and below target during weeks 48–52.FundingNovo Nordisk.
Moving cholera vaccines ahead of the epidemic curve
Authors: Ziad A Memish, Lucille Blumberg, Amal Saif Al-Maani, Rama Baru, Eve Dube, George F Gao, Daniel B Jernigan, Yee-Sin Leo, Joseph Sriyal Malik Peiris, Jakir Hossain B Masud, Jodie McVernon, Justice Nonvignon, Folasade Tolulope Ogunsola, Helen Reese, Rana Muhammad Safdar, Kumnuan Ungchusak, Lothar H Wieler, David Heymann
Journal: The Lancet (2023)
CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression
Authors: Alexander R. Terry, Veronique Nogueira, Hyunsoo Rho, Gopalakrishnan Ramakrishnan, Jing Li, Soeun Kang, Koralege C. Pathmasiri, Sameer Ahmed Bhat, Liping Jiang, Shafi Kuchay, Stephanie M. Cologna, Nissim Hay
Journal: Cell Metabolism (2023)
Excessive concentrations of kinase inhibitors in translational studies impede effective drug repurposing
Authors: Chuan Liu, Scott M. Leighow, Kyle McIlroy, Mengrou Lu, Kady A. Dennis, Kerry Abello, Donovan J. Brown, Connor J. Moore, Anushka Shah, Haider Inam, Victor M. Rivera, Justin R. Pritchard
Journal: Cell Reports Medicine (2023)

Drug repositioning seeks to leverage existing clinical knowledge to identify alternative clinical settings for approved drugs. However, repositioning efforts fail to demonstrate improved success rates in late-stage clinical trials. Focusing on 11 approved kinase inhibitors that have been evaluated in 139 repositioning hypotheses, we use data mining to characterize the state of clinical repurposing. Then, using a simple experimental correction with human serum proteins in in vitro pharmacodynamic assays, we develop a measurement of a drug's effective exposure. We show that this metric is remarkably predictive of clinical activity for a panel of five kinase inhibitors across 23 drug variant targets in leukemia. We then validate our model's performance in six other kinase inhibitors for two types of solid tumors: non-small cell lung cancer (NSCLC) and gastrointestinal stromal tumors (GISTs). Our approach presents a straightforward strategy to use existing clinical information and experimental systems to decrease the clinical failure rate in drug repurposing studies.
TCT-725 Blinded 3D Computational Modeling Derived Peak Areal Stretch From Pre-TAVR CT Is Predictive of Aortic Root Rupture Post-TAVR
Authors: Taylor S. Becker, Austin Kluis, Karim Al-Azizi, Molly Szerlip, Lakshmi Dasi
Journal: Journal of the American College of Cardiology (2023)
TCT-672 Impact of Coronary Pathophysiological Phenotypes on 5-Year Survival: A Post Hoc Analysis of the SYNTAX III Revolution Trial
Authors: TsungYing Tsai, Bo Wang, Xingqiang He, Mick Renkens, Kai Ninomiya, Shigetaka Kageyama, Nozomi Kotoku, Kotaro Miyashita, Akihiro Tobe, Yoshinobu Onuma, Patrick Serruys
Journal: Journal of the American College of Cardiology (2023)
TCT-658 Novel Electrocardiogram-Generating Technique Using Artificial Intelligence: From 2- to 12-Lead
Authors: Hak Seung Lee, Jeong Min Son, Jong-Hwan Jang, Ga In Han, Ah-Hyun Yoo, Sora Kang, Jun-Myoung Kwon
Journal: Journal of the American College of Cardiology (2023)
TCT-674 Impact of Global Coronary Physiological Assessment on the 5-Year Survival After Coronary Artery Bypass Surgery: A Post Hoc Analysis of the SYNTAX III Revolution Trial
Authors: TsungYing Tsai, Xingqiang He, Mick Renkens, Bo Wang, Kai Ninomiya, Shigetaka Kageyama, Nozomi Kotoku, Kotaro Miyashita, Akihiro Tobe, Yoshinobu Onuma, Patrick Serruys
Journal: Journal of the American College of Cardiology (2023)
TCT-449 Artificial Intelligence to Predict Optimal Procedural Outcome After Mitral Transcatheter Edge-to-Edge Repair.
Authors: Mathias Claeys, Tejas Vyas, Mohsena Chowdhury, Patrick Prud'Homme, Xiaojiao Xiao, Akshay Bagai, Mark Peterson, Gianluigi Bisleri, Gordon Moe, Kim Connelly, Jeremy Edwards, Neil Fam, Guanghui Wang, Geraldine Ong
Journal: Journal of the American College of Cardiology (2023)
TCT-667 Patterns in Stent Failure After Bifurcation PCI: An OCTOBER Trial Substudy
Authors: Omeed Neghabat, Lene Andreasen, Søren-Haldur Rasmussen, Peep Laanmets, Indulis Kumsars, Johan Bennett, Matthias Heigert, Ole Havndrup, Jan-Peter Van Kuijk, Simone Biscaglia, James Spratt, Evald Christiansen, Niels Holm
Journal: Journal of the American College of Cardiology (2023)
TCT-751 Routine LV Pacing Wire for TAVR With Balloon-Expandable Valves: Safety and Efficacy
Authors: Dimytri Siqueira, Alberto Cervone, Michelle Birtche, Louis Ohe, Auristela Ramos, Lucas Lemos, Gabriel Saad, Diego Lujan, Ibraim Pinto, Ricardo Costa, Fausto Feres
Journal: Journal of the American College of Cardiology (2023)
TCT-649 Impact of a Novel Hybrid Nanocoated Nitinol Drug-Eluting Stent on Below-the-Knee Atherosclerotic Disease: 2023 Update
Authors: Terumitsu Hasebe, Shunto Maegawa, Kenta Bito, Shunsuke Kamei, Yoko Usami, Yukihisa Ogawa, Yutaka Okamoto, Taku Ishikawa, Masayuki Sasaki, Makoto Hosaka, Emi Matsuoka, Tomohiro Matsumoto, Takuji Yamagami, Yasutaka Baba, Elazer Edelman
Journal: Journal of the American College of Cardiology (2023)
TCT-756 Evaluation of Concordance of Aortic Complex Measurements Using Dedicated Software for TAVR Planning in Comparison to Cardiovascular Imaging Specialists
Authors: José Henrique Delamain, Lucas Lemos, Alberto Cervone, Louis Ohe, Rodolfo Staico, Ricardo Costa, Michelle Birtche, Fausto Feres, Dimytri Siqueira
Journal: Journal of the American College of Cardiology (2023)
TCT-678 Long-Term Follow-up From the Use of Sirolimus Coated Balloons in De Novo Coronary lesions in a Real-World Population From 3 High-Volume European Centers
Authors: Sandeep Basavarajaiah, Gianluca Caiazzo, Luca Golino, Ameenathul Mazaya Fawzy, Sampath Athukorala, Nitin Kumar, George Pulikal, Luca Testa, Harkaran Kalkat
Journal: Journal of the American College of Cardiology (2023)
TCT-656 Coronary Vasomotor Response to Intracoronary Ergonovine Provocation Test According to the Severity of an Insignificant Coronary Artery Stenosis
Authors: Tae Shik Park, Byoung Geol Choi, Se Yeon Choi, Jae Kyeong Byun, Seung-Woon Rha
Journal: Journal of the American College of Cardiology (2023)
TCT-668 Age-Inclusive Assessment of Transcatheter Aortic Valve Replacement Outcomes in Hematologic Cancer Patients: An Insight From the National Database
Authors: Olayiwola Bolaji, Faizal Ouedraogo, Saeed Shoar, Endurance Evbayekha, Varinder Bansro, Olanrewaju Adabale, M. Chadi Alraies
Journal: Journal of the American College of Cardiology (2023)
TCT-720 Patient-Reported Outcomes in Tricuspid Valve Intervention: Patient Preference Results From the TRISCEND II Trial
Authors: Michael Brener, Colin Barker, Charles Davidson, Akhil Narang, Rahul Sharma, Christiane Haeffele, Pradeep Yadav, Vinod Thourani, Susheel Kodali, Rebecca Hahn, Raj Makkar, Moody Makar, Jörg Hausleiter, Michael Nabauer, William O'Neill, Dee Dee Wang, Brian Lindman, Firas Zahr, Scott Chadderdon, Mackram Eleid, Sorin Pislaru, Melissa Mancilla, Lisa Kemp, Sarah Mollenkopf, Michael Ryan, David Cohen
Journal: Journal of the American College of Cardiology (2023)
TCT-740 Multidisciplinary Team Approach to Reducing Vascular Complications in MCS Impella Support Patients
Authors: Haroon Faraz, Ankitkumar Patel, Pranaychandra Vaidya, Osman Yousafzai, Kanika Mody, Stacey Damito, David Landers
Journal: Journal of the American College of Cardiology (2023)
TCT-660 Treatment of Coronary Lesions With a Novel Crystalline Sirolimus-Coated Balloon
Authors: Mehdi Madanchi, Matthias Bossard, Giacomo Maria Cioffi, Yannick Spahr, Irena Majcen, Varis Gjergjizi, Julian Brunner, Yuan Zhi, Adrian Attinger-Toller, Florim Cuculi
Journal: Journal of the American College of Cardiology (2023)
TCT-655 Predictors of In-Hospital Mortality of Cardiogenic Shock in STEMI Population: Results From 1 of the Busiest Nonsurgical Heart Attack Centers in the UK
Authors: Huda Abu-Own, Simon Littlewood, Michael McGarvey, Adam Marzetti, Kerry Hall, Vikram Khanna, Rajiv Rampat, Nilesh Pareek, Darlington Okonko, Smriti Saraf
Journal: Journal of the American College of Cardiology (2023)
TCT-685 Underlying Atrial Septal Defect in Lung and Liver Transplantation: Mortality and Stroke Risk
Authors: Bilal Hussain, Pradeep Devarakonda, Saikrishna Patibandla, Suganya Manoharan, Daniel Abascal-Gonzalez, Sohrab Singh, Keerthi Ramireddy, Anoop Koshy, Cesar Ayala-Rodriguez, Sarath Reddy, Parasuram Krishnamoorthy
Journal: Journal of the American College of Cardiology (2023)
Extracellular matrix-templating fibrous hydrogels promote ovarian tissue remodeling and oocyte growth
Authors: Claire E. Nason-Tomaszewski, Emily E. Thomas, Daniel L. Matera, Brendon M. Baker, Ariella Shikanov
Journal: Bioactive Materials (2023)

Synthetic matrices which mimic the extracellular composition of native tissue create a comprehensive model for studying development and disease. Here, we have engineered a composite material which retains cell-secreted ECM for the culture of ovarian follicles by embedding electrospun dextran fibers functionalized with basement membrane binder (BMB) peptide in PEG hydrogels. In the presence of ECM-sequestering fibers, encapsulated immature primordial follicles and ovarian stromal cells aggregated into large organoid-like structures with dense deposition of laminin, perlecan, and collagen I, leading to steroidogenesis and significantly greater rates of oocyte survival and growth. We determined that cell aggregation restored key cell-cell interactions critical for oocyte survival, whereas oocyte growth was dependent on cell-matrix interactions achieved in the presence of BMB. Here we have shown that sequestration and retention of cell-secreted ECM along synthetic fibers mimics fibrous ECM structure and restores the cell-cell and cell-matrix interactions critical for engineering an artificial ovary.
The effect and control of malaria in pregnancy and lactating women in the Asia-Pacific region
Authors: Holger W Unger, Sanjaya Acharya, Lachlan Arnold, Connie Wu, Anna Maria van Eijk, Georgia R Gore-Langton, Feiko O ter Kuile, Elvin Lufele, R Matthew Chico, Ric N Price, Brioni R Moore, Kamala Thriemer, Stephen J Rogerson
Journal: The Lancet Global Health (2023)