tbuckley/cabot-search huggingface dataset:
AB1376 RELATIONSHIP BETWEEN INTRANEURAL HYPERVASCULARIZATION OF THE MEDIAN NERVE IN POWER DOPPLER AND ELECTROMYOGRAPHIC SEVERITY STAGES IN THE DIAGNOSIS OF SEVERITY OF CARPAL TUNNEL SYNDROME (PRELIMINARY RESULTS)
Authors: H. Fouzia, T. Fatima Zahrae, K. Berrada, N. Takhrifa, I. Berrichi, F. E. Abourazzak
Journal: Annals of the Rheumatic Diseases (2022)

Background Carpal tunnel syndrome (CTS) is the most common tunnel syndrome in the upper limbs. Ultrasound has been increasingly used in recent years in the diagnosis of positive and severe CTS. Although the diagnosis of severity is essentially based on the ENMG, several studies have shown that ultrasound data can also constitute criteria for the severity of CTS. Objectives The objective of our study is to evaluate the relationship between intraneural hypervascularization of the median nerve in power Doppler and the severity of CTS measured by ENMG. Methods This is a descriptive cross-sectional study of patients with clinically retained CTS. We excluded from the study operated patients and patients who received cortisone infiltration in the previous six months. All patients underwent ultrasound examination (B mode and Doppler mode) and electromyography one week apart. The severity stages of CTS have been defined according to the classification of Stevens (1997). The study is still ongoing. Results To date we have included 14 patients with typical signs of CTS. 25 wrists were examined sonographically and by ENMG. The mean age of the patients was 54± 10 years. Bilateral SCC was present in 11 patients. Of the 25 affected wrists: 10, 7 and 8 were classified by the ENMG as mild, moderate and severe SCC respectively. On ultrasound, positive Doppler was found in 5 wrists (20% of wrists studied): Doppler was present in 10% of wrists with mild-stage SCC, 14.3% of wrists with moderate-stage SCC and in 37.5% of wrists with severe SCC. But this difference was not statistically significant (p=0.31) probably related to the small size of our current sample (study still ongoing). Conclusion The preliminary results of our study suggest that intraneural hypervascularization of the median nerve in power Doppler could provide additional information on the severity of carpal tunnel syndrome. Results to be confirmed by the final results. References [1]Ghasemi-Esfe et All. Color and power Doppler US for diagnosing carpal tunnel syndrome and determining its severity. Radiology 2011 [2]Mohammadi A et All. Correlation between the severity of carpal tunnel syndrome and color Doppler sonography findings. AJR Am J Roentgenol 2012 [3]Ghasemi-Esfe AR, Morteza A, Khalilzadeh O, Mazloumi M, GhasemiEsfe M, Rahmani M. Color Doppler ultrasound for evaluation of vasomotor activity in patients with carpal tunnel syndrome. Skeletal Radiol 2012; 41: 281-6 Disclosure of Interests None declared
POS1353 COMPOSITION AND ASSOCIATIONS OF THE GUT MICROBIOTA IN BECHET’S DISEASE WITH PERIPHERAL LYMPHOCYTE SUBSETS AND CYTOKINES
Authors: J. Luo, Q. Y. Su, J. Q. Zhang, J. Qiao, S. X. Zhang, C. Wang, X. F. LI
Journal: Annals of the Rheumatic Diseases (2022)

Background Bechet’s disease (BD) is a chronic multisystemic vasculitis with genetic and abnormal immune response. Growing evidences suggests gut microbiota compositional alteration may have an association with immune dysfunction in patients with BD. Objectives This study aims to investigate the gut microbiota between BD and healthy controls (HCs) and analyse relevancy between bacterial and peripheral lymphocyte subsets and cytokines. Methods Fecal samples obtained from 22 BD patients and 22 normal-age and gender-matched HCs in this study. The gut microbiota were assessed with 16s rRNA sequencing and the flow cytometry was used to dectect peripheral lymphocyte subsets. C-reaction protein (CRP), Erythrocyte sedimentation rate (ESR), complement C3 and C4 were also assigned for disease activity measure. The edgeR package was used for differential abundance analysis. Difference of alpha diversity indices, bacterial abundances, and the F/B ratio were carried out using the Wilcoxon rank-sum test (R v.4.0.1). The differential abundance of flora and CRP, ESR, C3 and C4 between BD patients and HCs was assessed by pearson’s correlation analysis. Results As for alpha diversity, the Shannon (p &lt; 0.05) and Simpsonance analysis. Difference of alpha diversity indices, bacterial abundances, and the F/B ratio were carried out using the Wilcoxon rank-sum test (R v.4.0.1). The differential abundamicrobial community structures between BD and HCs (R = 0.053, p = 0.051; Figure 1B). The gut microbiota compositions of BD differed form those of HCs (Figure 1C). Four species of flora distinctly difference were found in BD (p &lt; 0.05; Figure 1D). There was significant positive correlations between Tregs and Verrucomicrobiota (p &lt; 0.05), and Proteobacteria (p &lt; 0.05), Th1 and Proteobacteria (p &lt; 0.05), ESR and Verrucomicrobiota (p &lt; 0.01), but negatives correlation between TNF-α and Desulfobactbiota (p &lt; 0.05; Figure 1E). Conclusion Pattients with CTD had disbiosis of gut microbiota charaterized by impared diversity and abnomal composition, which was closely correlated with peripheral lymphocyte subsets and disease activity measures. References [1]Margaret Alexander, Qi Yan Ang, Renuka R Nayak, et al. Human gut bacterial metabolism drives Th17 activation and colitis. Cell Host Microbe. 2022 Jan 12;30(1):17-30.e9. doi: 10.1016/j.chom.2021.11.001. Epub 2021 Nov 24. [2]Yi-Wen Tsai, Jia-Ling Dong, Yun-Jie Jian, et al. Gut Microbiota-Modulated Metabolomic Profiling Shapes the Etiology and Pathogenesis of Autoimmune Diseases. Microorganisms. 2021 Sep 10;9(9):1930. doi: 10.3390/microorganisms9091930. Acknowledgements This work was supported by the National Natural Science Foundation of China (No. 82001740). Disclosure of Interests None declared
AB1218 AURICULOTHERAPY AS A TREATMENT FOR CHRONIC NECK PAIN: AN INTERVENTIONAL COMPARATIVE STUDY
Authors: O. Saidane, W. Lahmar, F. Saadi, A. Ben Tekaya, S. Bouden, R. Leila, R. Tekaya, I. Mahmoud, L. Abdelmoula
Journal: Annals of the Rheumatic Diseases (2022)

Background Data indicates promising benefits of auriculotherapy (AT) in pain management of several pathologies. Common cervical pain (CCP) is recurrent plaint often resistant to standard treatment. And use of auriculotherapy as a therapeutic solution in neck pain has not been well explored. Objectives The aim of our study is to evaluate efficacy of a single session of AT in the management of CCP’s pain and disability. Methods We conducted an interventional comparative study. Fifty patients with CCP consulting were divided in two group of 25: group A underwent a session of AT, group P had a placebo treatment using a detuned ultrasound machine. Evaluation of the patients was performed before, and right after the intervention. The Neck and Pain Disability Scale (NPDS) questionnaire. It includes 3 areas: F1 for functional disability, F2 for movement-induced pain and F3 for pain in static position. Results We enrolled 32 women and 18 men with an average age of 47. Epidemiological, clinical and radiographic features were comparable for both groups, except for the standard of living and the consumption of analgesics, which were significantly higher in the group A (p=0.027and p&lt;0.001, respectively). Initially, NPDS total score and F1, F2, F3 sub scores were comparable in both groups. After the intervention, all scores had decreased significantly. In the A group: NPDS total went from 34.3 to 22.9 (p&lt;0.001), F1 went from 9.5 to 6.2 (p&lt;0.001), F2 went from 16.5 to 11.9 (p&lt;0.001), F3 from 8 to 5.4 (p&lt;0.001). In the P group: NPDS total decreased from 28.9 to 26 (p=0.001), F1 from 6.3 to 5.7 (p= 0.001), F2 going from 14.4 to 13.3 (p =0.013), F3 went from 8 to 7.3 (p=0.006). When we compared the scores after the intervention, the improvement was statistically higher in the A group for all scores (p&lt;0.001 for total, F1 and F2, and p=0.002 for F3 sub score). Conclusion Our study revealed that a single session of auriculotherapy is effective on short term in the treatment of pain and disability related to CCP. This alternative technique may gain its place in the therapeutic management protocol to overcome disability of chronic neck pain. Disclosure of Interests None declared
AB1070 INFECTIOUS SACROILIITIS: A RARE ENTITY IN RHEUMATOLOGY!
Authors: S. Rekik, O. Hamdi, S. Bousaid, S. Rahmouni, S. Jemmali, H. Sahli, M. Elleuch
Journal: Annals of the Rheumatic Diseases (2022)

Background Infectious sacroiliitis (ISI) is a rare disease, with misleading clinical symptoms that often delay the diagnosis. Objectives The aim of this study was to describe the clinical, microbiological, therapeutic and radiological characteristics of ISI. Methods This descriptive, retrospective study included all ISI patients that were hospitalized in our rheumatology department over an 11-year period [2010 - 2021]. Results Overall, 25 cases of ISI were identified, comprising 15 men (60%) and 10 women (40%), with a mean age of 48.7±10.5 years [21-67]. ISI was caused by pyogenic microorganisms in 12 cases (70.5%), mycobacterium tuberculosis in 7 cases (41.2%), and brucella spp in 6 cases (35.3%). The mean symptoms duration in pyogenic, brucellar and tuberculous ISI was 42 days, 67 days, and 255 days, respectively. The onset was brutal in 88% of pyogenic ISI, while it was progressive in 68% of brucellar ISI and in all cases of tuberculous ISI. Lumbogluteal pain was the most common symptom (80%). The involvement of the sacroiliac joint was always unilateral, and inflammatory in 92% of cases. The other most common symptoms included: fever (80%), impotence (68%), and lumbago (52%). An infectious source was found in 17 patients: 41.2% pulmonary (tuberculosis, n=7), 29.4% urinary, 17.6% gynecological (postpartum, n=3), and 11.7% septicemic (n=2). Fifteen patients (60%) had a biological inflammatory syndrome. Leukocytosis was found in 11 cases (64.7%). Pelvic x-ray showed a narrowing of the sacroiliac joints in 52% of cases. CT of the sacroiliac joints showed erosions in 60% of cases. Sacroiliac MRI showed erosions (45%), joint effusion (32%), and psoas abscess (14%). A second infectious site was found in 20% of cases: psoas abscess (n=2), and a collection of the soft tissues facing the joint (n=1). A pathogenic agent was isolated by means of blood culture (48%; staphylococcus aureus 56%, streptococcus 28%, and staphylococcus with negative coagulase 16%), articular biopsy (40%), cytobacteriological examination of urine (20%), Wright serology (20%), and Tuberculin skin test (6.2%). All patients received germ-adapted antibiotics. No patients have had surgical treatment. Evolution was favorable in most cases (n=11). Four patients complained of residual pain in the sacroiliac region. None of the patients relapsed. Conclusion Although IS is rare, it remains an emergency diagnosis. A rigorous physical examination is essential in order to detect this infection early. Antibiotics often lead to clinical improvement, making thus the need for surgery exceptional. Disclosure of Interests None declared
MECP2-related pathways are dysregulated in a cortical organoid model of myotonic dystrophy
Authors: Kathryn H. Morelli, Wenhao Jin, Shashank Shathe, Assael A. Madrigal, Krysten L. Jones, Joshua L. Schwartz, Tristan Bridges, Jasmine R. Mueller, Archana Shankar, Isaac A. Chaim, John W. Day, Gene W. Yeo
Journal: Science Translational Medicine (2022)

Myotonic dystrophy type 1 (DM1) is a multisystem, autosomal-dominant inherited disorder caused by CTG microsatellite repeat expansions (MREs) in the 3′ untranslated region of the dystrophia myotonica-protein kinase ( DMPK ) gene. Despite its prominence as the most common adult-onset muscular dystrophy, patients with congenital to juvenile-onset forms of DM1 can present with debilitating neurocognitive symptoms along the autism spectrum, characteristic of possible in utero cortical defects. However, the molecular mechanism by which CTG MREs lead to these developmental central nervous system (CNS) manifestations is unknown. Here, we showed that CUG foci found early in the maturation of three-dimensional (3D) cortical organoids from DM1 patient–derived induced pluripotent stem cells (iPSCs) cause hyperphosphorylation of CUGBP Elav-like family member 2 (CELF2) protein. Integrative single-cell RNA sequencing and enhanced cross-linking and immunoprecipitation (eCLIP) analysis revealed that reduced CELF2 protein–RNA substrate interactions results in misregulation of genes critical for excitatory synaptic signaling in glutamatergic neurons, including key components of the methyl-CpG binding protein 2 (MECP2) pathway. Comparisons to MECP2 (y/−) cortical organoids revealed convergent molecular and cellular defects such as glutamate toxicity and neuronal loss. Our findings provide evidence suggesting that early-onset DM1 might involve neurodevelopmental disorder-associated pathways and identify N -methyl- d -aspartic acid (NMDA) antagonists as potential treatment avenues for neuronal defects in DM1.
AB1127 ANTIOSTEOPOROTIC TREATMENT AND COVID-19 RISK: IS THERE AN ASSOCIATION?
Authors: N. Grygorieva, M. Bystrytska, N. Zaverukha, A. Musiienko
Journal: Annals of the Rheumatic Diseases (2022)

Background Nowadays, the COVID-19 and its complications are considered an important medical issue with aggravated medico-social outcomes, both at the worldwide scale, and in terms of various individual countries. Despite the recent ASBMR, AACE, Endocrine Society, ECTS and NOF recommendations according to osteoporosis management in the era of COVID-19 the influence of antiosteoporotic drugs on disease incidence and severity continue to be studied [1, 2]. Objectives The purpose of this study was to assess the COVID-19 risk for the patients receiving the parenteral bisphosphonate or Denosumab treatment, and the severity of its course in the systemic osteoporosis patients. Methods We performed the phone survey and studied the results of 195 patients (92 % women; mean age – 62.7±10.8 years, height – 161.0±8.0 cm, body weight – 68.9±12.3 kg) with systemic osteoporosis depending on the current use of parenteral antiresorptive drugs (Zoledronic acid, Ibandronic acid, or Denosumab, n=125) and compared the results with patients with osteoporosis who did not use any antiosteoporotic drugs previously (n=70). The mean duration of antiosteoporotic treatment did not vary across the groups, accounting for 15 [9-27] months. Prior to the beginning of the antiosteoporotic therapy, all the patients had a confirmed diagnosis of osteoporosis at the Ukrainian scientific-medical Center of osteoporosis. Results We did not reveal any significant differences in the COVID-19 frequency and severity depending on the presence and type of parenteral antiosteoporotic therapy. Additionally, there were no differences depending on patients’ age of sex, obesity presence, and other osteoporosis risk factors. The risk of COVID-19 in the patients with systemic osteoporosis did not differ depending on antiresorptive drug use, amounting (Odd Ratio (OR) 95 % CI) to 1.1 (0.6-2.0), or on the use of the definite antiosteoporotic drug (for the Zoledronic acid - 0.9 (0.4-2.0), the Ibandronic acid - 1.1 (0.5-2.3), and for the Denosumab - 1.6 (0.5-5.2). Conclusion Our study did not reveal any significant differences in the COVID-19 frequency and severity depending on the presence and type of parenteral antiosteoporotic therapy. We conclude that parenteral antiosteoporotic drugs (Zoledronic acid, Ibandronic acid, or Denosumab) do not have an influence on COVID-19 frequency and severity and can be recommended for the continuation of treatment of patients with osteoporosis. References [1]Joint Guidance on Osteoporosis Management in the Era of COVID-19 from the ASBMR, AACE, Endocrine Society, ECTS &amp; NOF. https://www.asbmr.org/about/statement-detail/joint-guidance-on-osteoporosis-management-covid-19 . [2]Blanch-Rubió J, Soldevila-Domenech N, Tío L, et al (2020) Influence of anti-osteoporosis treatments on the incidence of COVID-19 in patients with non-inflammatory rheumatic conditions. Aging (Albany NY). 12(20):19923-19937. doi:10.18632/aging.104117. Disclosure of Interests None declared
AB1549-HPR SOCIAL ACTIVITY AND QUALITY OF LIFE IN PATIENTS WITH THE ARTICULAR FORM OF RHEUMATOID ARTHRITIS
Authors: N. Shuvalova, S. Lezhenina, E. Guryanova
Journal: Annals of the Rheumatic Diseases (2022)

Background Patients with rheumatoid arthritis (RA) often experience persistent, prolonged pain. This requires taking pain medications (most often non-steroidal anti-inflammatory drugs) every day for many years or decades. Pain can lead to decreased social activity and emotional changes. Therefore, the quality of life of patients with rheumatoid arthritis may decrease. Objectives The purpose of the study: to determine the quality of life in patients with rheumatoid arthritis. Methods A survey was conducted using a questionnaire that included aspects of Health-related quality of life (HRQOL). The study was conducted from September 2020 to September 2021, in the Chuvash Republic, Cheboksary. The study involved 75 patients (n = 75) with articular form of RA, aged 25 to 70 years (mean age 52.2±4.63), 82% women. In 24 (32%) respondents, 1 degree of inflammatory activity was verified, in 36 (48%) - the second, in 15 (20%) - the third degree. The first stage was diagnosed in 9 (12%) patients (according to Steinbroker), in 42 (56%) cases stage 2 of RA development was diagnosed, in 18 (24%) cases - the third stage, 6 (8%) patients had stage 4. The diagnosis of RA was based on the criteria (ACR). Statistical processing of the results was carried out in MS Office Excel programs. Results More than half of the patients (55.87%) experienced daily pain in the peripheral joints, which worsened their mood and well-being. When assessing the degree of pain, 68.45% of patients assessed their pain according to VAS as moderate (7.2±0.96 points). When assessing physical activity (PF) in 33.17% of patients, its decrease was noted as “significant”. When assessing social activity (SF), a decrease in this indicator was revealed: 56.32% of the surveyed noted a “moderate” decrease, 33.16% as “significant”. 23.94% of the surveyed noted the decrease in the indicator of general health (GH) as “moderate”. When assessing mental health (MH), a decrease in the indicator was found in 43.67% of patients as “moderate”. When assessing emotional problems in disability (RE), there was a “significant” decrease in the indicator in 54% of respondents. 62.24% of the surveyed patients consider the loss of freedom of movement to be the biggest problem in RA. 56.24% of patients rated their satisfaction with their lives as “average degree of satisfaction”; 43.76% of patients as “low satisfaction”. Conclusion As a result of the survey, it can be stated that 43.76% of respondents have a “low degree of satisfaction” with life. In order for the doctor to have all the objective information, it is necessary to adequately and timely evaluate changes in HRQOL for the purpose of early diagnosis and timely treatment of RA. Disclosure of Interests None declared
POS0599 IMPACT OF TREAT-TO-TARGET THERAPY ON BONE MINERAL DENSITY LOSS IN PATIENTS WITH RHEUMATOID ARTHRITIS: A PROSPECTIVE COHORT STUDY
Authors: H. Huang, Y. Wang, W. Xie, Y. Geng, D. Gao, Z. Zhang
Journal: Annals of the Rheumatic Diseases (2022)

Background Osteoporosis is a common comorbidity of rheumatoid arthritis (RA). Although RA disease activity has been demonstrated to be associated with bone loss in previous studies, most of them were cross-sectional studies and not in the context of treat-to-target (T2T) strategies. Objectives To evaluate the association of disease activity with bone mineral density (BMD) changes in the context of T2T strategies in a prospective RA cohort. Methods RA patients were enrolled from a prospective CENTRA cohort of Peking University First Hospital. BMD was repeated at baseline, 1-year and then every other year. Time-adjusted mean disease activity scores were adopted to reflect the overall disease activity during follow-up. The influence of univariable associations between predictors and BMD was investigated using linear regression. Results A total of 268 patients were included in our analysis. Their mean age was 50 (12.9) years old. At enrollment, the mean (SD) DAS28-ESR was 3.70 (1.17), and the median (IQR) CDAI and SDIA was 10 (14.45) and 10.30 (16.53), respectively. Osteoporosis at lumbar spine was observed in 23.1% patients and 9.3% at femoral neck at enrollment. Older age, higher SDAI score and lower BMI were found to be associated with osteoporosis at baseline. Reevaluations of BMD at 1 year was applied in 144 patients. Mean decreases of BMDs were 1.75 % at the lumbar spine and 1.40 % at femoral neck at 1 year form baseline, respectively. Patients who achieved remission had less yearly bone loss at lumbar spine (p=0.036). Female gender was identified as a risk factor in the multiple linear regression analyses, and lower disease activity and bisphosphonates were protective factors of continuous bone loss. Conclusion Disease activity is associated with bone loss in RA patients in the context of T2T strategies, and those who achieved remission had less yearly bone loss. Disclosure of Interests None declared
AB0867 Particularities of uveitis associated with spondyloarthritis: Data from the moroccan RBSMR registry
Authors: I. Roki Chaoui, N. Akasbi, I. El Mezouar, R. Abouqal, L. Achemlal, F. Allali, R. Bahiri, I. El Bouchti, A. EL Maghraoui, I. Ghozlani, H. Hassikou, I. Hmamouchi, I. Linda, O. Mkinsi, R. Niamane, T. Harzy
Journal: Annals of the Rheumatic Diseases (2022)

Background Acute anterior uveitis is the most frequent extra-articular manifestation in spondyloarthritis (SpA). [1] Objectives The purpose of this study is to assess the prevalence of uveitis during SpA and to identify associated factors with its presence. Methods A cross-sectional multicentric observational study was conducted; the main data source was the Moroccan registry of biological therapies in rheumatic diseases (RBSMR registry). Patients, included from May 2017 to January 2019, were all adult patients (age &gt; 18 years old), presenting SpA, according to ASAS (Assessment of Spondyloarthritis International Society) classification criteria for SpA 2010. Demographic and clinical characteristics, disease activity, radiographic damage and functional ability have been compared between two groups of patients: Patients with SpA suffering from uveitis and patients without uveitis. General and specific data regarding uveitis were collected. Results 194 patients were included in the study. The mean age was 40.22 ± 13.68 years. The sex ratio was 1, 7 (man/woman). The mean duration of disease was 615.90 ± 349.12 weeks. 96.4 % of the patients had axial involvement, 70 % had peripheral involvement and 61.5 % had enthesic involvement. SpA was radiographic in 88.1 % of the cases and coxitis was found in 40.9 %. The mean erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) was 39.04 ± 27.16 mm/h and 32.87 ± 38.77 mg/l, respectively. HLA B27 was positive in 34 % of patients. The mean ASDAS (Ankylosing Spondylitis Disease Activity Score) ESR, BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) and BASFI (Bath Ankylosing Spondylitis Functional Index) was 3, 19 ± 2,118; 4.8 ± 1.8 and 5.29 ± 2.21, respectively. Uveitis was seen in 14.5% of cases. The bi-variate analysis did not reveal any statistically significant difference between the two groups regarding demographic and clinical characteristics, disease activity and radiographic damage. Conclusion Acute anterior uveitis is the most frequent extra-articular manifestation in spondyloarthritis (SpA). The presence of uveitis in Moroccan patients diagnosed with SpA wasn’t associated with specific characteristics. Even though, its screening is systematic because it conditions the treatment. References [1]I. Gómez-García, M.L. Ladehesa-Pineda, M.Á. Puche-Larrubia et al. Uveitis as the first symptom in spondyloarthritis and its association with the evolution of the disease. Results from the REGISPONSER registry. Joint Bone Spine 88 (2021) 105136 Disclosure of Interests None declared