tbuckley/cabot-search huggingface dataset:
Analysis of clinical features of ovarian cancer (OC) and breast cancer (BC) among BRCA-mutated (BRCA+) and sporadic (NH) double tumors.
Authors: Maria Ornella Nicoletto, Lucia Borgato, Grazia Artioli, Alessandra Perin, Fable Zustovich, Cristina Ghiotto, Haralabos Koussis, Alessandro Cappetta, Simone Mocellin, Lara Furini, Maurizia Dalla Palma, Alfredo Ercoli, Pietro Litta, Giovanni B. Nardelli, Vittorina Zagonel
Journal: Journal of Clinical Oncology (2012)

e12037 Background: Women BRCA+ are at significant risk of developing both OC and BC. Double tumors could arise also in NH patients. Whether the clinical outcome of double OC and BC is different in BRCA+ and in NH subjects is unknown. Methods: The databases of the Istituto Oncologico Veneto (IOV), Medical Oncology Department of Mirano (VE) and Thiene (VI) were searched to identify the clinical and pathological features of (BC) and (OC) arisen in BRCA+ subjects as well as patients with both malignancy but tested negative/no-tested/unknown for BRCA1/2 mutation (NH). The primary endpoint was to establish if OC instead of BC needs a more intensive follow-up because it principally affects patient’s prognosis. Patients were censored at last follow-up or death (any cause) for determination of overall survival (OS). OS estimates were determined using the Kaplan-Meier method and compared by means of log-rank test. The Fisher’s exact test and the t-test were used to compare frequencies and means between groups, respectively. Results: 24/31 (77%) BRCA+ and 30/49 (61%) NH had BC as their first malignancy (p=0.15). Among NH, 20 were BRCA test negative, 20 were untested and 9 unknown. BRCA+ were younger than NH at diagnosis of first malignancy (mean age 51 vs 56y, p=0.055). Bilateral BC was more frequent in BRCA+ than in NH (78.6% vs 28.6% p=0.001). Stage III-IV OC at diagnosis were 74% in BRCA vs 61% in NH (p=0.34). Locally advanced (stage II-III) BC was significantly more frequent in BRCA+ vs NH (75% vs 42%, p=0.03). No OS difference was observed between BRCA+ and NH subjects (P=0.99). Death for progression of ovarian cancer was observed in 11/31 (35%) in BRCA+ vs 10/49 (20%) patients in NH (p=0.19). No progression of breast cancer was reported in either groups. Conclusions: OC is the killer malignancy among patients affected by OC and BC, both in BRCA+ and in NH subjects. In patients with double tumors, irrespective of their pathological features, a more conserving management for BC and an intensive follow-up for OC are suggested.
Changes in left ventricular shape and cavity area after myocardial splinting in a Cardiomyopathy dog model: A real-time 3-dimensional echocardiographic study Jian Xin Qin, Takahiro Shiota, Masami Takagaki, Lisa A. Cardon, Yoshie Ochiai, Tomotsugu Tabata, Patrick M. McCarthy, Cyril J. Schweich, Todd J. Mortier, Jr., Richard F. Schroeder, James D. Thomas. The Cleveland Clinic Foundation, Cleveland, OH, Myocor Inc, Plymouth, MN
Journal: Journal of the American College of Cardiology (2001)
Prognostic clinical factors in pretreated colorectal cancer patients receiving regorafenib: Implications for clinical management.
Authors: Michela Del Prete, Riccardo Giampieri, Fotios Loupakis, Tiziana Prochilo, Lisa Salvatore, Luca Faloppi, Maristella Bianconi, Alessandro Bittoni, Giuseppe Aprile, Alberto Zaniboni, Alfredo Falcone, Mario Scartozzi, Stefano Cascinu
Journal: Journal of Clinical Oncology (2015)

591 Background: Most of the patients receiving regorafenib do not seem to benefit from this treatment approach and are therefore exposed to unnecessary toxicity. Angiogenesis and inflammation-related factors may have a relevant role in modulating the activity of anti-angiogenetic drugs such as regorafenib. In our study, we investigated LDH serum levels, platelet, neutrophil, and lymphocyte counts, and neutrophil-to-lymphocyte ratio (NLR) in predicting clinical outcomes for colorectal cancer patients receiving regorafenib. The final aim was to individuate an easy to use and reliable selection tool for these patients in the clinical practice. Methods: We collected LDH serum levels, neutrophil, lymphocyte, and platelet counts within one month before the start of regorafenib in 208 pretreated metastatic colorectal cancer patients. Cut-off values were calculated by ROC curve analysis. Survival analysis was performed by Kaplan-Meier method, and multivariate analysis by Cox method. Results: At multivariate analysis: high platelet count (p=0.0439), low lymphocyte count (p=0.0013), and high NLR (p=0.0237) were related to worse overall survival (OS); high neutrophil count and high NLR (p=0.0058) were related to worse progression free survival (PFS). Among 52 (25%) patients who were negative for all risk factors, a significant correlation was found with improved OS and PFS if compared with the group of patients with at least one risk factor. In particular, median OS was respectively 15.9 vs. 3.1 months (HR: 3.81, 95% CI: 2.32-4.82, p&lt;0.0001) whereas median PFS was 5.9 vs. 2.1 months (HR: 2.62, 95% CI: 2.06-3.86, p&lt;0.0001). Conclusions: We can speculate that colorectal cancer patients showing high neutrophil, high platelet, low lymphocyte count or high NLR may not be optimal candidates for regorafenib treatment. After confirmation in further prospective series, these clinical factors could play a role in the treatment strategy process.
Assessments of mortality, morbidity, and nutritional status in Somalia during the 1991-1992 famine. Recommendations for standardization of methods
Authors: L. P. Boss
Journal: JAMA (1994)

<h3>Objectives.</h3> —To evaluate the various survey methods used in Somalia between 1991 and early 1993 while assessing documentation of mortality and malnutrition rates and common causes of morbidity and mortality. <h3>Data Sources.</h3> —Twenty-three population surveys were identified from the Center for Public Health Surveillance for Somalia, the United Nations Children's Fund, and other humanitarian organizations. <h3>Study Selection.</h3> —Only surveys with defined populations and apparently systematic methodology that focused on mortality, morbidity, and/or nutritional status were included. <h3>Results.</h3> —Extensive methodological differences were found among the 23 surveys. Target populations and sampling strategies varied widely. Twelve studies were considered not reproducible. Of the 16 studies assessing mortality, only eight assessed cause of death. Use of units of measurement and inclusion of denominators in rate calculations were inconsistent. None of the studies provided confidence intervals around the point estimates of the rates. Of the 11 studies providing information on morbidity, none provided case definitions. And in the 16 studies reporting nutritional status, a variety of measurement methods and definitions of malnutrition were used. Three studies presented information based on midupper-arm circumference measurements, and 10 presented weight-for-height data below 70% and 80% of the reference median; only four studies presented z scores. <h3>Conclusions.</h3> —While the results of some studies may have influenced policy and program management decisions, their effects may have been limited by failure to adequately document results and by differences among studies in objectives, design, parameters measured, methods of measurement, definitions, and analysis methods. We recommend that agencies conducting population studies in emergency situations define clear study objectives, use standard sampling and data collection methods, and ensure precise written documentation of study objectives, methods, and results. (<i>JAMA</i>. 1994;272:371-376)
The Croonian Lectures on the Pharmacological Action and Therapeutic Uses of the Nitrites and Allied Compounds: Delivered at the Royal College of Physicians of London
Authors: D. J. Leech
Journal: BMJ (1893)

The cases noted sufficiently illustrate the dangerous an l fatal effects of cardiac and pulmonary thrombosis.Others have occurred in my experience of which I have kept the notes, but it seems needless to multiply them.It is to be noted that however much or little these cases may be refer- able to malarial causes, septic conditions were then very rife in Indian hospitals.
Food Allergy May Simulate Rheumatoid Arthritis
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A SELF-SACRIFICING PHYSICIAN.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Panic disorder may respond to new 'antidepressants'
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mixtures of Four Organochlorines Enhance Human Breast Cancer Cell Proliferation
Authors: Joachim Payne, Martin Scholze, Andreas Kortenkamp
Journal: Environmental Health Perspectives (2001)

In view of the large differences between the concentrations of estrogenic chemicals needed to elicit effects in in vitro assays and their levels in human tissues, it is hard to explain possible health risks in terms of exposure to individual compounds. Human populations, however, are exposed to mixtures of estrogenic and estrogen-like agents and it is necessary to consider the impact of combined effects. We assessed the combined effects of 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2,2-trichloroethane (o,p'-DDT), 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE), beta-hexachlorocyclohexane (beta-HCH), and 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane (p,p'-DDT) on the induction of cell proliferation in MCF-7 cells. All four compounds are persistent organochlorines that can be found in human tissues. We performed extensive concentration-response analyses with the single agents to predict the effects of two mixtures of all four compounds with different mixture ratios. We calculated the predictions by using the pharmacologically well-founded models of concentration addition and independent action and then tested them experimentally. o,p'-DDT, p,p'-DDE, beta-HCH, and p,p'-DDT acted together to produce proliferative effects in MCF-7 cells. The combined effect of the four agents could be predicted on the basis of data about single agent concentration-response relationships. Regression analysis demonstrated that there were combination effects even when each mixture component was present at levels at or below its individual no-observed-effect-concentration. We assessed combination effects in two ways: First, evaluations in relation to the proliferative responses induced by single mixture components revealed that the combination effects were stronger than the effects of the most potent constituent. Thus, according to this method of evaluation, the combined effects may be termed synergistic. Second, comparisons with the expected effects, as predicted by concentration addition and independent action, showed excellent agreement between prediction and observation. With this approach, the combined effect of all four compounds can be termed additive.
Presidential Address
Authors: FRANKLIN M. HANGER
Journal: Annals of Internal Medicine (1963)

Special Article1 July 1963Presidential AddressFRANKLIN M. HANGER, M.D., F.A.C.P.FRANKLIN M. HANGER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-1-111 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe honor of addressing one of the greatest bodies of physicians in our time imposes a challenge for wisdom and clear-sightedness. No one can expect from a brief Presidential Address the birth of a new verity. But truth, as we must live with it, is like the human form. It has infinite shape and proportion. And it is a speaker's frustrating task to become a sort of fashion stylist—to drape its nudity, create subtle allure, and conceal unseemly contours.We physicians of today find ourselves unwillingly enmeshed in a social and technologic transformation which is creating new tempos, new credos,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Staunton, VirginiaDelivered before the Forty-fourth Annual Session of the American College of Physicians, Denver, Colorado, April 1-5, 1963.Requests for reprints should be addressed to Franklin M. Hanger, M.D., Cobble Hill, Staunton, Virginia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1963Volume 59, Issue 1_Part_1Page: 111-114KeywordsBirth Issue Published: 1 July 1963 PDF downloadLoading ...
Leads from the MMWR. Update: poliomyelitis outbreak--Finland, 1984-1985
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The pulmonary circulation
Authors: A. P. Fishman
Journal: JAMA (1978)

THE HISTORY of the pulmonary circulation provides a measure of man's thinking about himself and his place in the universe. For centuries before<i>De Motu Cordis</i>in 1628,<sup>1</sup>the blood vessels of the lungs were incorporated into an elaborate scheme that explained the origin and distribution of spirits that animated and sustained the human being. Only after the circulation was described could the speculative natural philosophy of ancient times give way to the observations and interpretations that we now take for granted. <h3>THE GROWTH OF IDEAS</h3> The thinking of the ancients was dominated by the views of Aristotle as updated by Galen in the second century AD.<sup>2</sup>According to Galen, the body was governed by a hierarchy of three principal organs: the liver, the heart, and the brain. According to this schema, the liver was the source of "natural spirits" that the veins distributed throughout the body. These
QL-25 * THE SYMPTOM BURDEN OF PRIMARY BRAIN TUMORS: EVIDENCE FOR A CORE SET OF TUMOR AND TREATMENT-RELATED SYMPTOMS
Authors: E. Vera-Bolanos, A. Acquaye, M. Gilbert, T. Armstrong
Journal: Neuro-Oncology (2014)

BACKGROUND: A set of common cancer and treatment-related symptoms has been proposed to enhance both quality of care and clinical research in patients with a variety of solid tumors. These symptoms include anorexia, anxiety, constipation, depression, diarrhea, dyspnea, fatigue, insomnia, nausea, pain, neuropathy, and vomiting. Using data from several prospective studies, this study evaluated the impact of tumor grade, disease stage and treatment in patients with primary brain tumors on the reporting of symptoms. METHODS: Aggregate symptom report data using the MD Anderson Symptom Instrument -Brain Tumor (MDASI-BT) from 617 patients enrolled in 8 clinical studies was used. Descriptive statistics were used to report the prevalence and severity of symptoms as they relate to tumor grade, treatment stage (newly diagnosed, on active treatment, on surveillance, at recurrence), and KPS. RESULTS: The sample was primarily white(83%) males(59%), with high grade gliomas(75%) with KPS ≥ 90(71%). Over 50% of patients reported at least 10 concurrent symptoms, and 40% of patients reporting at least 3 moderate-severe symptoms. Fatigue, drowsiness, difficulty remembering, difficulty with sleep, and distress were the most severe symptoms reported by all tumor grades. Patients with either grade 4 tumors or tumor recurrence reported weakness and difficulty speaking as severe. Newly diagnosed patients or on active treatment also reported irritability and problems concentrating as most severe. Functional interference of symptoms with ability to work, perform activities, walk, and enjoy life was reported by more than 25% of patients. Low KPS was associated with more severe symptoms and functional impact. CONCLUSIONS: These results support a core set of symptoms that are common across brain tumor patients that may impact clinical care, and assessment of treatment benefit. Although some symptoms overlap with those reported in patients with other solid tumors, the additional symptoms and functional limitations underscore the clinical complexity of patients with brain tumors.
Bless the seats and the children: the physician and the legislative process
Authors: R. S. Sanders
Journal: JAMA (1984)

Motor vehicle accidents are the leading cause of death and injury for all children beyond infancy,<sup>1</sup>and more than 90% of children ride unprotected in automobiles.<sup>2</sup>Physicians have recognized that the current epidemic of highway casualties among our very young is essentially preventable and that state-by-state child restraint laws are the most practical approach to "immunizing" most of these children against their leading killer. Since the nation's first child-restraint legislation, the Tennessee Child Protection Act, was implemented in January 1978, 49 states have enacted similar laws. In each state, pediatricians and other physicians have played a key role in lobbying for this effort. This heartening experience should stimulate physicians of all specialties to consider extending these laws to protect older children and adults from the carnage witnessed daily on our streets and highways. The remarkable dividends resulting from the Tennessee law, as reported in this issue (p 2571)
Pulmonary Consumption, Pneumonia, and Allied Diseases of the Lungs; Their Etiology, Pathology and Treatment, with a Chapter on Physical Diagnosis.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal