tbuckley/cabot-search huggingface dataset:
Grundzüge der Hygiene. Unter Berücksichtigung der Gesetzgebung des Deutschen Reiches und Österreichs.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Differential Regulation of Histone Deacetylase 4 by CaM Kinase II and Protein Kinase A in Response to Cardiac Beta-Adrenergic Signaling
Authors: Johannes Backs
Journal: Circulation (2007)

Abstract 281 Johannes Backs, David Patrick, Thea Backs, Svetlana Bezprozvannaya, Xiaoxia Qi, Joseph A Hill, Eric N Olson, UT Southwestern Medical Center at Dallas, Dallas, TX Johannes Backs, 2007 Finalist and Presenting Author
A Synopsis of Surgery.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4332: Targeting MYC overexpressing leukemia with cardiac glycoside proscillaridin through downregulation of histone acetyltransferases
Authors: Elodie Marie Da Costa, Gregory Armaos, Gabrielle McInnes, Annie Beaudry, Gael Moquin-Beaudry, Virginie Bertrand-Lehouillier, Maxime Caron, Pascal St-Onge, Jeffrey R. Jonhson, Nevan Krogan, Yuka Sai, Michale Downey, Moutih Rafei, Meaghan Boileau, Kolja Eppert, Ema Florez-Diaz, Andre Haman, Trang Hoang, Daniel Sinnett, Christian Beausejour, Serge McGraw, Noel J. Raynal
Journal: Cancer Research (2019)

Abstract Targeting MYC oncogene remains a major therapeutic goal in anticancer therapies. Here, we demonstrate that proscillaridin, a cardiac glycoside approved for heart failure treatment, causing Na+/K+ pump inhibition, targets efficiently MYC overexpressing cancer cells. At clinically relevant doses, proscillaridin induced rapid downregulation of MYC protein level, and produced growth inhibition preferentially against MYC overexpressing leukemic cell lines including lymphoid and myeloid stem cell populations. Whole transcriptome analysis with RNA sequencing of acute lymphoblastic leukemia cells showed a downregulation of gene sets involved in MYC pathways and cell replication, and an upregulation of genes involved in hematopoietic differentiation induced by proscillaridin treatment. Gene expression changes were associated with an epigenetic remodeling of chromatin active marks. Proscillaridin induced a significant loss of lysine acetylation in histone H3 (at lysine 9, 14, 18 and 27). In addition, mass spectrometry analysis revealed a loss of lysine acetylation in non-histone proteins such as MYC itself, MYC target proteins, and a series of histone acetylation regulators. Global loss of acetylation correlated with the rapid downregulation of histone acetyltransferase proteins (such as CBP, P300, TIP60 and GCN5) involved in histone and MYC acetylation. Overall, these results strongly support the repurposing of proscillaridin in MYC overexpressing leukemia and suggest a novel strategy to target MYC by inducing the downregulation of histone acetyltransferases involved in its stability. Citation Format: Elodie Marie Da Costa, Gregory Armaos, Gabrielle McInnes, Annie Beaudry, Gael Moquin-Beaudry, Virginie Bertrand-Lehouillier, Maxime Caron, Pascal St-Onge, Jeffrey R. Jonhson, Nevan Krogan, Yuka Sai, Michale Downey, Moutih Rafei, Meaghan Boileau, Kolja Eppert, Ema Florez-Diaz, Andre Haman, Trang Hoang, Daniel Sinnett, Christian Beausejour, Serge McGraw, Noel J. Raynal. Targeting MYC overexpressing leukemia with cardiac glycoside proscillaridin through downregulation of histone acetyltransferases [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4332.
STAT5 Requires the N-Domain for Suppression of miR15/16, Induction of Bcl-2, and Survival Signaling in Myeloproliferative Disease.
Authors: Geqiang Li, Kristy L. Miskimen, Zhengqi Wang, Xiu Yan Xie, Jennifer Brenzovich, John J Ryan, William Tse, Richard Moriggl, Kevin D. Bunting
Journal: Blood (2009)
Splenic Anemia
Authors: Arno G. Motulsky
Journal: JAMA (1961)

<h3>To the Editor:—</h3> The 43-year-old man with thrombocytopenia, foam cells typical of "familial splenic anemia," and negative skeletal roentgenograms (Questions and Answers,<i>JAMA</i><b>174</b>:1759, 1960) undoubtedly has Gaucher's disease. This diagnosis can easily be established by the characteristic appearance of the bone marrow cells. Symptomatic thrombocytopenia in this disease often responds to splenectomy. Patients with Gaucher's disease often live comfortably and without symptoms. Since the man's spleen is removed, it is unlikely that he will develop progressive anemia. If he is hematologically normal and symptom-free at this time, his insurance risk is quite good and can be considered impaired mildly, if at all.
PERMANENT CATHETERIZATION.
Authors: J. RILUS EASTMAN
Journal: JAMA (1901)

Varying opinions are held as to the usefulness of the retained catheter after perineal operations upon the posterior urethra. Most authorities, in discussing external urethrotomy, pass the retention catheter without comment, advocating the use of the short perineal drainage-tube only. By some it is advised that continual catheterization be employed for twenty-four or forty-eight hours, and that at the end of that time intermittent catheterization be begun. A few favor retention of the catheter for a longer period, varying from three to six days. By no writer with whose counsels I am familiar are we taught to leave the catheter in after perineal urethrotomy until the urethral and perineal wounds are firmly healed. Permanent catheterization for a period as long as twenty days is common practice in hematuria, having its origin in trauma of the prostate, and, as is well known, it is often indicated and employed in certain cases
Should Health Systems Agencies Be Involved in Environmental Health Planning?
Authors: C. Wayne Higgins, B. U. Philips, John G. Bruhn, Larry T. Aker
Journal: Environmental Health Perspectives (1980)

Public Law 93-641 provides health systems agencies (HSAs) with a broad planning preview which has enabled a number of agencies to address environmental health issues in their health systems plans. Opponents of HSA involvement in environmental health planning charge that these activities overextend agency resources, duplicate efforts of other government agencies and involve HSAs in
Using Reproductive Effect Markers to Observe Subclinical Events, Reduce Misclassification, and Explore Mechanism
Authors: Maureen C. Hatch, George Friedman-Jimenez
Journal: Environmental Health Perspectives (1991)

Biological markers of effect, in general less widely available than exposure markers, do exist in the field of reproduc- tion and increasingly are being used in epidemioogical studies.Several such markers, including semen quality, menstrual hormones, early pregnancy loss, and placental abnormalities, are cited as examples.We argue the value ofeffect markers for detecting subclinical events that are critical for reproductive performance.Such studies can extend knowledge of the true frequency and determinates of reproductive disorders.A second portion of the paper deals with the role of effect markers in reducing disease misclassification.With a hypothetical early pregnancy study as a case in point, we illustrate the degree and direction ofbias associated with several different protocols and encourage epidemiologists to weigh these quantitative considerations in deciding on study design.Finally, we discuss uses of biological markers to explore mechanisms, drawing on experience in an ongoing reproductive study that is testing a hypothetal pathway from maternal psychosocial stress to reduced fetal growth using urine catecholamine levels as a physiological marker of exposure and placental vascular abnormalities as a marker of effect.
Leukemic reticuloendotheliosis. Loss of platelet defect after splenectomy
Authors: A. S. Feiner
Journal: JAMA (1978)

A 59-year-old woman with leukemic reticuloendotheliosis had pancytopenia and hypersplenism. Before splenectomy, she had an abnormal bleeding time and a severe defect of secondary-wave platelet aggregation. After splenectomy, the platelet count returned to normal, and the aggregation defect was no longer present. This response suggests that the spleen may contribute to the platelet dysfunction.
Role of Programmed Cell Death in Carcinogenesis
Authors: John T. Isaacs
Journal: Environmental Health Perspectives (1993)

Cells possess within their repertoire of genetic programs the ability not only to proliferate and be functionally active, but also to activate and undergo a process of self-induced destruc- tion.This process, called programmed cell death, involves a genetic reprogramming of the cell that results in an energy-dependent cascade of biochemical and morphological changes within the cell that result in its death and elimination.Activation of this programmed death process is controlled by a series of endogenous cell-type-specific signals.In addition, a variety of exoge- nous cell-damaging treatments (e.g., radiation, chemicals, and viruses) can activate this path- way if sufficient injury to the cell occurs.Because a cell must undergo a series of molecular changes to acquire the malignant phenotype and because these changes are often induced by agents or treatment that damage the cell over an extended period of time, anything that enhances the survival of initiated/damaged cells will promote the carcinogenic process.This paper presents an overview of the regulation and mechanism of programmed cell death and how derangement of this regulation may be involved in carcinogenesis.
The Dancing Mouse.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anatomical Atlas of Obstetric Diagnosis and Treatment.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neurology
Authors: H. Houston Merritt, William King Jordan
Journal: New England Journal of Medicine (1947)

PHYSIOLOGIC studies of significance in 1946 include the reports on the effect of di-iso-propylfluorophosphate on transmission of the nerve impulse and the effect of this compound on the symptoms of myasthenia gravis. The poor results obtained with the use of di-iso-propylfluorophosphate in patients with myasthenia gravis, although there was a great decrease in plasma cholinesterase, suggest that the therapeutic effect of neostigmine in this disease is not related to its effect on the cholinesterase.Important clinical studies were made on diseases of the cerebral blood vessels, the measurement of sympathetic activity in nerve injuries by the dermometer and the treatment . . .
Non-conventional Inhibitory CD4+Foxp3−PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity
Authors: Roberta Zappasodi, Sadna Budhu, Matthew D. Hellmann, Michael A. Postow, Yasin Senbabaoglu, Sasikanth Manne, Billel Gasmi, Cailian Liu, Hong Zhong, Yanyun Li, Alexander C. Huang, Daniel Hirschhorn-Cymerman, Katherine S. Panageas, E. John Wherry, Taha Merghoub, Jedd D. Wolchok
Journal: Cancer Cell (2018)
P165 Results of the Northumbria Direct access CXR project
Authors: M Weatherhead
Journal: Thorax (2015)

<h3></h3> Northumbria Healthcare (NHCT) traditionally had a low number of patients presenting with early stage lung cancer leading to low resection rates. In addition a high number of patients presented through the emergency route rather than through target clinics. A local initiative was developed to try to improve the local presentation and diagnosis rates. The Northumbria initiative utilised primary care education, a social marketing project and a direct access CXR project which ran for 12 months. The assessment criteria for direct access CXR were based on NICE guidance and patients meeting these criteria could self-present for a CXR. Is the patient over 50 Has the patient had a chest x-ray in the last 3/52 Has the patient developed a new and persistent cough for more than 3/52 Has the patient had persistent chest pain for more than 3/52 Has the patient had blood in their phlegm <h3>Results</h3> Over 12 months 768 CXR examinations were carried out. 751 people presented a cough, 192 with chest pain and 33 with haemoptysis. 18 CT`s were requested due to a suspicious CXR and 52 people had a follow up CXR. 19 of these 70 were reviewed in a chest clinic. 4 lung cancers were detected, 2 of which were early stage and the patients had radical treatment. 5 pulmonary nodules were identified, for which interval follow-up was planned. <h3>Conclusion</h3> The Northumbria Walk-in project proved successful in terms of delivering a campaign message to the local population. The trust communications team won a regional award for the best “low budget” campaign for this project. The detection rate for lung cancer was not higher than one would expect from performing CXR`s on a population of similar age with a smoking history and on current evidence did not provide evidence for continuing the walk in CXR programme. However, over the 2 years while this project was being developed and awareness of cancer was targeted there was a 6% rise in the rate of early stage lung cancer locally suggesting that the combined awareness raising approach both locally and nationally has had some effect on presentation rate.
Thirteenth International Symposium for Comparative Research on Leukemia and Related Diseases and Post-Symposium Satellite Workshops
Journal: JNCI Journal of the National Cancer Institute (1987)

Thirteenth International Symposium for Comparative Research on Leukemia and Related Diseases and Post-Symposium Satellite Workshops Get access JNCI: Journal of the National Cancer Institute, Volume 79, Issue 1, July 1987, Page 197, https://doi.org/10.1093/jnci/79.1.197-d Published: 01 July 1987
Digestive System Cancer among Persons Subjected to Occupational Inhalation of Asbestos Particles: A Literature Review with Emphasis on Dose Response
Authors: Marvin A. Schneiderman
Journal: Environmental Health Perspectives (1974)

Human data show a dose–response relationship between industrial exposure to asbestos and later development of cancer of the bronchus and lung and of cancer of the digestive tract. The data do not provide much evidence for a threshold or for the existence of a clearly “safe” level of exposure. Good dose–response data, with quantitative estimates of dose are uncommon; however, in all the literature reviewed only one paper did not support the conclusion that increased exposure to inhaled asbestos particles leads to increased digestive system cancer.
Initial Results from the Northstar Study (HGB-204): A Phase 1/2 Study of Gene Therapy for β-Thalassemia Major Via Transplantation of Autologous Hematopoietic Stem Cells Transduced Ex Vivo with a Lentiviral βΑ-T87Q -Globin Vector (LentiGlobin BB305 Drug Product)
Authors: Alexis A. Thompson, John E Rasko, Suradej Hongeng, Janet L. Kwiatkowski, Gary Schiller, Christof von Kalle, Marina Cavazzana, Philippe Leboulch, Alexandria Petrusich, Sandeep Soni, Mark C. Walters
Journal: Blood (2014)
Role Of Pharmacokinetics In Safety Evaluation And Regulatory Considerations
Authors: R. Scheuplein
Journal: The Annual Review of Pharmacology and Toxicology (1990)

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism ...Read More
Comparative efficacy of three mumps vaccines during disease outbreak in eastern Switzerland: cohort study
Journal: BMJ (1999)

sonality, communication skills, and interest in medical topics are assessed and scored.Offers are made to the 260 interviewees with the top scores.In 1997, 2701 candidates from the United Kingdom and the rest of the European Union applied to Nottingham through the Universities Colleges and Admission Service.The decision for each applicant was noted along with ethnic group, sex, and stage of the process.Statistical comparison of frequencies was by 2 test with Yates's correction.Significantly more non-white and male applicants were rejected at the academic and questionnaire stages, whereas significantly more white and female applicants were rejected at the statement review and interview stages (table).The net effect was that significantly more white and female applicants were offered a place.
AN UNUSUAL PAIN SYNDROME ASSOCIATED WITH THE PRESENT WAVE OF INFLUENZA.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Heart
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal