tbuckley/cabot-search huggingface dataset:
Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis
Authors: Claire Petit, Anne Lee, Jun Ma, Benjamin Lacas, Wai Tong Ng, Anthony T C Chan, Ruey-Long Hong, Ming-Yuan Chen, Lei Chen, Wen-Fei Li, Pei-Yu Huang, Terence Tan, Roger K C Ngan, Guopei Zhu, Hai-Qiang Mai, Edwin P Hui, George Fountzilas, Li Zhang, Alexandra Carmel, Dora L W Kwong, James Moon, Jean Bourhis, Anne Auperin, Jean-Pierre Pignon, Pierre Blanchard, Anne Aupérin, Pierre Blanchard, Ellen Benhamou, Jean Bourhis, Alexandra Carmel, Somvilai Chakrabandhu, Anthony TC Chan, Lei Chen, Ming-Yuan Chen, Qiu-Yan Chen, Yong Chen, Richard J Chappell, Horace Choi, Daniel TT Chua, Melvien Lee Kiang Chua, George Fountzilas, Julian Higgins, Ming Huang Hong, Ruey-Long Hong, Pei-Yu Huang, Edwin Pun Hui, Chin-Fu Hsiao, Michael Kam, Georgia Angeliki Koliou, Dora L W Kwong, Benjamin Lacas, Shu-Chuan Lai, Ka On Lam, Michael L LeBlanc, Anne WM Lee, Ho Fun Victor Lee, Wen Fei Li, Yoke Lim, Brigette Ma, Jun Ma, Hai-Qiang Mai, Frankie Mo, James Moon, Wai Tong Ng, Roger Ngan, Camille Ollivier, Brian O'Sullivan, Claire Petit, Jean-Pierre Pignon, Sharon X Poh, Gerta Rücker, Jonathan Sham, Yoke Lim Soong, Ying Sun, Terence Tan, Lin-Quan Tang, Yuk Tung, Joseph Wee, Xuang Wu, Tingting Xu, Li Zhang, Yuan Zhang, Guopei Zhu
Journal: The Lancet Oncology (2023)
Recovery and symptom trajectories up to two years after SARS-CoV-2 infection: population based, longitudinal cohort study
Authors: Tala Ballouz, Dominik Menges, Alexia Anagnostopoulos, Anja Domenghino, Hélène E Aschmann, Anja Frei, Jan S Fehr, Milo A Puhan
Journal: BMJ (2023)

To evaluate longer term symptoms and health outcomes associated with post-covid-19 condition within a cohort of individuals with a SARS-CoV-2 infection.Population based, longitudinal cohort.General population of canton of Zurich, Switzerland.1106 adults with a confirmed SARS-CoV-2 infection who were not vaccinated before infection and 628 adults who did not have an infection.Trajectories of self-reported health status and covid-19 related symptoms between months six, 12, 18, and 24 after infection and excess risk of symptoms at six months after infection compared with individuals who had no infection.22.9% (95% confidence interval 20.4% to 25.6%) of individuals infected with SARS-CoV-2 did not fully recover by six months. The proportion of individuals who had an infection who reported not having recovered decreased to 18.5% (16.2% to 21.1%) at 12 months and 17.2% (14.0% to 20.8%) at 24 months after infection. When assessing changes in self-reported health status, most participants had continued recovery (68.4% (63.8% to 72.6%)) or had an overall improvement (13.5% (10.6% to 17.2%)) over time. Yet, 5.2% (3.5% to 7.7%) had a worsening in health status and 4.4% (2.9% to 6.7%) had alternating periods of recovery and health impairment. The point prevalence and severity of covid-19 related symptoms also decreased over time, with 18.1% (14.8% to 21.9%) reporting symptoms at 24 months. 8.9% (6.5% to 11.2%) of participants reported symptoms at all four follow-up time points, while in 12.5% (9.8% to 15.9%) symptoms were alternatingly absent and present. Symptom prevalence was higher among individuals who were infected compared with those who were not at six months (adjusted risk difference 17.0% (11.5% to 22.4%)). Excess risk (adjusted risk difference) for individual symptoms among those infected ranged from 2% to 10%, with the highest excess risks observed for altered taste or smell (9.8% (7.7% to 11.8%)), post-exertional malaise (9.4% (6.1% to 12.7%)), fatigue (5.4% (1.2% to 9.5%)), dyspnoea (7.8% (5.2% to 10.4%)), and reduced concentration (8.3% (6.0% to 10.7%)) and memory (5.7% (3.5% to 7.9%)).Up to 18% of individuals who were not vaccinated before infection had post-covid-19 condition up to two years after infection, with evidence of excess symptom risk compared with controls. Effective interventions are needed to reduce the burden of post-covid-19 condition. Use of multiple outcome measures and consideration of the expected rates of recovery and heterogeneity in symptom trajectories are important in the design and interpretation of clinical trials.ISRCTN18181860, .
Health technology assessment for cancer medicines across the G7 countries and Oceania: an international, cross-sectional study
Authors: Kristina Jenei, Adam J N Raymakers, Arnaud Bayle, Karin Berger-Thürmel, Avi Cherla, Kazunori Honda, Christopher C G A Jackson, Deme Karikios, Dario Trapani, Scott Berry, Bishal Gyawali
Journal: The Lancet Oncology (2023)
Understanding the burden of post-covid-19 condition
Authors: Qiao Wu
Journal: BMJ (2023)

Understanding the burden of post-covid-19 condition A complex picture is emerging, along with urgent priorities for future research Qiao Wu doctoral candidateCovid-19 cases and deaths have decreased globally, 1 yet, the long term consequences of infection, including post-covid-19 condition (often known as long covid), are still being managed.Most people who have covid-19 recover soon after the acute phase of the disease but others experience persistent health problems for months or longer, and these problems can impact quality of life and ability to work. 2 -6 Understanding the trajectory of symptom burden and recovery from post-covid-19 condition is crucial for policy making, treatment decisions, and care coordination.
Stress-Related Neural Activity Associates With Coronary Plaque Vulnerability and Subsequent Cardiovascular Events
Authors: Neng Dai, Xianglin Tang, Xinyu Weng, Haidong Cai, Jianhui Zhuang, Guangjie Yang, Fan Zhou, Ping Wu, Bao Liu, Shaofeng Duan, Yongfu Yu, Weifeng Guo, Zhiguo Ju, Longjiang Zhang, Zhenguang Wang, Yuetao Wang, Bin Lu, Hongcheng Shi, Juying Qian, Junbo Ge
Journal: JACC. Cardiovascular imaging (2023)
Prognostic Significance of Papillary Muscle Infarction After Reperfused STEMI
Authors: Casper W.H. Beijnink, Stijn Raessens, José T. Ortiz-Pérez, Vicente Bodí, Marta Alamar, Daniel Lorenzatti, Jose Gavara, Albert Alonso Tello, José F. Rodriguez Palomares, Robin Nijveldt
Journal: JACC. Cardiovascular imaging (2023)
Late Right Heart Failure After Left Ventricular Assist Device Implantation
Authors: Indranee Rajapreyar, Osama Soliman, Yevgeniy Brailovsky, Ryan J. Tedford, Gregory Gibson, Paul Mohacsi, Alexander G. Hajduczok, Vakhtang Tchantchaleishvili, Georg Wieselthaler, J. Eduardo Rame, Kadir Caliskan
Journal: JACC Heart Failure (2023)
Maleimide as the PEG end-group promotes macrophage-targeted drug delivery of PEGylated nanoparticles in vivo by enhancing interaction with circulating erythrocytes
Authors: Xin Wang, Xiandi Meng, Kuirong Mao, Hongmei Chen, Xiuxiu Cong, Feiqi Liu, Jialiang Wang, Shuhan Liu, Yanbao Xin, Ge Zhu, Huizhu Tan, Yong-Guang Yang, Tianmeng Sun
Journal: Biomaterials (2023)
Prospective evaluation of the efficacy, safety, and optimal biomarker enrichment strategy for nangibotide, a TREM-1 inhibitor, in patients with septic shock (ASTONISH): a double-blind, randomised, controlled, phase 2b trial
Authors: Bruno François, Simon Lambden, Tom Fivez, Sebastien Gibot, Marc Derive, Jean-Marie Grouin, Margarita Salcedo-Magguilli, Jérémie Lemarié, Nicolas De Schryver, Ville Jalkanen, Tarik Hicheur, Jean-Jacques Garaud, Valérie Cuvier, Ricard Ferrer, Morten Bestle, Ville Pettilä, Jean-Paul Mira, Camille Bouisse, Emmanuelle Mercier, Joris Vermassen, Vincent Huberlant, Isabelle Vinatier, Nadia Anguel, Mitchell Levy, Pierre-François Laterre, Pierre Asfar, Mai-Anh Nay, Christophe Guitton, Jean-Pierre Quenot, David Tran-Van, Julien Bohe, Gaëtan Plantefève, Saadalla Nseir, Jean-Yves Lefrant, Xavier Monnet, Laurent Papazian, Christophe Vinsonneau, Jean-Michel Constantin, Alexandre Mebazaa, Haikel Oueslati, Dolores Escudero, Fernando Martinez Sagasti, Enrique Piacentini, Paula Ramirez Galleymore, Thierry Dugernier, David Fagnoul, Isabelle Michaux, Allan Seibert, Matti Reinikainen, Thorbjørn Grøfte, Ignacio Martin-Loeches, John Laffey
Journal: The Lancet Respiratory Medicine (2023)
Emerging interleukin targets in the tumour microenvironment: implications for the treatment of gastrointestinal tumours
Authors: Lindsay Kathleen Dickerson, Jason A Carter, Karan Kohli, Venu G Pillarisetty
Journal: Gut (2023)

The effectiveness of antitumour immunity is dependent on intricate cytokine networks. Interleukins (ILs) are important mediators of complex interactions within the tumour microenvironment, including regulation of tumour-infiltrating lymphocyte proliferation, differentiation, migration and activation. Our evolving and increasingly nuanced understanding of the cell type-specific and heterogeneous effects of IL signalling has presented unique opportunities to fine-tune elaborate IL networks and engineer new targeted immunotherapeutics. In this review, we provide a primer for clinicians on the challenges and potential of IL-based treatment. We specifically detail the roles of IL-2, IL-10, IL-12 and IL-15 in shaping the tumour-immune landscape of gastrointestinal malignancies, paying particular attention to promising preclinical findings, early-stage clinical research and innovative therapeutic approaches that may properly place ILs to the forefront of immunotherapy regimens.
Evaluating workforce well-being: an investigation of healthcare professionals’ mental health and burnout symptoms at the Tokyo 2020 and Beijing 2022 Paralympic Games
Authors: Maaike Eken, Phoebe Runciman, Marelise Badenhorst, Cheri Blauwet, Vincent Gouttebarge, Leslie Swartz, Wayne Derman
Journal: British Journal of Sports Medicine (2023)

To explore the prevalence of symptoms of mental health conditions and burnout of healthcare professionals (HCPs) working during the Tokyo 2020 Paralympic Games and the Beijing 2022 Paralympic Winter Games.In this cross-sectional, observational study, HCPs working during the Tokyo 2020 and Beijing 2022 Paralympic Games were asked to complete an online, anonymous survey, which included demographic questions and questions regarding mental health symptoms including depression (Patient Health Questionnaire 9-item depression scale) and anxiety (Generalized Anxiety Disorder 7-item scale) as well as burnout (Maslach Burnout Inventory-Human Services Survey: depersonalisation, emotional exhaustion, personal accomplishment). Correlation coefficients (r) were calculated between demographic characteristics and mental health symptoms.In total, 256 HCPs (of 857 HCPs; 30%) completed the surveys. Twelve and eight per cent of HCP scores fell within the moderate to severe depression and moderate to severe anxiety categories, respectively. More than 30% reported moderate to high burnout (depersonalisation: 36%; emotional exhaustion: 36%; personal accomplishment: 58%). In addition, thoughts of self-harm and/or suicidality were reported by some HCPs (8%). Weak correlations were observed between age and depression (r=-0.13, p=0.046), anxiety (r=-0.16, p=0.010) and burnout (emotional exhaustion: r=-0.14, p=0.032; personal accomplishment: r=0.27, p<0.001).Although most HCPs reported good mental health, this study suggests that a subset of HCPs experienced symptoms of depression, anxiety, burnout or thoughts of self-harm during the Tokyo 2020 and Beijing 2022 Paralympic Games. While the generalisability of these findings outside of COVID-19 restrictions should be tested, appropriate guidance and mental health support of HCPs leading up to the Paralympic Games should be prioritised.
EMT/MET plasticity in cancer and Go-or-Grow decisions in quiescence: the two sides of the same coin?
Authors: Azamat Akhmetkaliyev, Noura Alibrahim, Darya Shafiee, Eugene Tulchinsky
Journal: Molecular Cancer (2023)

Epithelial mesenchymal transition (EMT) and mesenchymal epithelial transition (MET) are genetic determinants of cellular plasticity. These programs operate in physiological (embryonic development, wound healing) and pathological (organ fibrosis, cancer) conditions. In cancer, EMT and MET interfere with various signalling pathways at different levels. This results in gross alterations in the gene expression programs, which affect most, if not all hallmarks of cancer, such as response to proliferative and death-inducing signals, tumorigenicity, and cell stemness. EMT in cancer cells involves large scale reorganisation of the cytoskeleton, loss of epithelial integrity, and gain of mesenchymal traits, such as mesenchymal type of cell migration. In this regard, EMT/MET plasticity is highly relevant to the Go-or-Grow concept, which postulates the dichotomous relationship between cell motility and proliferation. The Go-or-Grow decisions are critically important in the processes in which EMT/MET plasticity takes the central stage, mobilisation of stem cells during wound healing, cancer relapse, and metastasis. Here we outline the maintenance of quiescence in stem cell and metastatic niches, focusing on the implication of EMT/MET regulatory networks in Go-or-Grow switches. In particular, we discuss the analogy between cells residing in hybrid quasi-mesenchymal states and GAlert, an intermediate phase allowing quiescent stem cells to enter the cell cycle rapidly.
Bivalent mRNA COVID-19 Vaccine–Related Pericarditis on 18F-FDG PET/CT
Authors: Yu-Chin Wu, Chia-Hung Kao, Chiung-Wei Liao, Shung Shung Sun, Te-Chun Hsieh
Journal: Clinical Nuclear Medicine (2023)

Abstract A 13-year-old boy was suspected with pericarditis after a second booster dose of bivalent mRNA COVID-19 vaccine. After specific preparation for cardiac inflammation with carbohydrate-free, high-fat diet, the 18 F-FDG PET/CT successfully demonstrated simultaneous presentation of vaccination-related axillary lymphadenopathy and pericarditis without the interference of physiological myocardial uptake.
Toward computational neuroconstructivism: a framework for developmental systems neuroscience
Authors: Duncan E. Astle, Mark H. Johnson, Danyal Akarca
Journal: Trends in Cognitive Sciences (2023)

Brain development is underpinned by complex interactions between neural assemblies, driving structural and functional change. This neuroconstructivism (the notion that neural functions are shaped by these interactions) is core to some developmental theories. However, due to their complexity, understanding underlying developmental mechanisms is challenging. Elsewhere in neurobiology, a computational revolution has shown that mathematical models of hidden biological mechanisms can bridge observations with theory building. Can we build a similar computational framework yielding mechanistic insights for brain development? Here, we outline the conceptual and technical challenges of addressing this theory gap, and demonstrate that there is great potential in specifying brain development as mathematically defined processes operating within physical constraints. We provide examples, alongside broader ingredients needed, as the field explores computational explanations of system-wide development.
Why children moralise harm to animals but not meat
Authors: Jared Piazza, Victoria Simpson, Luke McGuire
Journal: Trends in Cognitive Sciences (2023)

Many children care about animals yet are accepting of meat consumption. This may reflect a disconnect between children's meat eating, food-systems knowledge, and their moral evaluations. A theoretical framework is proposed for understanding the developmental trajectory of this disconnection. We discuss its components and the implications for dietary interventions.
N6‐methyladenosine modification of CENPF mRNA facilitates gastric cancer metastasis via regulating FAK nuclear export
Authors: Penghui Xu, Jing Yang, Zetian Chen, Xing Zhang, Yiwen Xia, Sen Wang, Weizhi Wang, Zekuan Xu
Journal: Cancer Communications (2023)

Abstract Background N6‐methyladenosine (m 6 A) modification is the most common modification that occurs in eukaryotes. Although substantial effort has been made in the prevention and treatment of gastric cancer (GC) in recent years, the prognosis of GC patients remains unsatisfactory. The regulatory mechanism between m 6 A modification and GC development needs to be elucidated. In this study, we examined m 6 A modification and the downstream mechanism in GC. Methods Dot blotting assays, The Cancer Genome Atlas analysis, and quantitative real‑time PCR (qRT‐PCR) were used to measure the m 6 A levels in GC tissues. Methylated RNA‐immunoprecipitation sequencing and RNA sequencing were performed to identify the targets of m 6 A modification. Western blotting, Transwell, wound healing, and angiogenesis assays were conducted to examine the role of centromere protein F (CENPF) in GC in vitro. Xenograft, immunohistochemistry, and in vivo metastasis experiments were conducted to examine the role of CENPF in GC in vivo. Methylated RNA‐immunoprecipitation‐qPCR, RNA immunoprecipitation‐qPCR and RNA pulldown assays were used to verify the m 6 A modification sites of CENPF . Gain/loss‐of‐function and rescue experiments were conducted to determine the relationship between CENPF and the mitogen‐activated protein kinase (MAPK) signaling pathway in GC cells. Coimmunoprecipitation, mass spectrometry, qRT‐PCR, and immunofluorescence assays were performed to explore the proteins that interact with CENPF and elucidate the regulatory mechanisms between them. Results CENPF was upregulated in GC and facilitated the metastasis of GC both in vitro and in vivo. Mechanistically, increased m 6 A modification of CENPF was mediated by methyltransferase 3, and this modified molecule could be recognized by heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), thereby promoting its mRNA stability. In addition, the metastatic phenotype of CENPF was dependent on the MAPK signaling pathway. Furthermore, CENPF could bind to FAK and promote its localization in the cytoplasm. Moreover, we discovered that high expression of CENPF was related to lymphatic invasion and overall survival in GC patients. Conclusions Our findings revealed that increased m 6 A modification of CENPF facilitates the metastasis and angiogenesis of GC through the CENPF/FAK/MAPK and epithelial‐mesenchymal transition axis. CENPF expression was correlated with the clinical features of GC patients; therefore, CENPF may serve as a prognostic marker of GC.
Degradable Antimicrobial Ureteral Stent Construction with Silver@graphdiyne Nanocomposite
Authors: Yang Zhang, Lizhen Wang, Yan Wang, Linhao Li, Jin Zhou, Dandan Dou, Zebin Wu, Lu Yu, Yubo Fan
Journal: Advanced Healthcare Materials (2023)

In the surgical treatment of urinary diseases, ureteral stents are commonly used interventional medical devices. Although polymer ureteral stents with polyurethane as the main constituent are widely used in the clinic, the need for secondary surgery to remove them and their propensity to cause bacterial infections greatly limit their effectiveness. To satisfy clinical requirements, an electrospinning-based strategy to fabricate PLGA ureteral stents with silver@graphdiyne is innovated. Silver (Ag) nanoparticles are uniformly loaded on the surface of graphdiyne (GDY) flakes. It is found that the incorporation of Ag nanoparticles into GDY markedly increases their antibacterial properties. Subsequently, the synthesized and purified Ag@GDY is homogeneously blended with poly(lactic-co-glycolic acid) (PLGA) as an antimicrobial agent, and electrospinning along with high-speed collectors is used to make tubular stents. The antibacterial effect of Ag@GDY and the porous microstructure of the stents can effectively prevent bacterial biofilm formation. Furthermore, the stents gradually decrease in toughness but increase in strength during the degradation process. The cellular and subcutaneous implantation experiments demonstrate the moderate biocompatibility of the stents. In summary, considering these performance characteristics and the technical feasibility of the approach taken, this study opens new possibilities for the design and application of biodegradable ureteral stents.
Localization of Brown Tumors With 18F-Fluorocholine PET/CT Imaging in Severe Primary Hyperparathyroidism
Authors: Jonas Werner, Hannes Grünig, Hannah Loher, Stefan Fischli, Klaus Strobel, Corinna Wicke
Journal: Clinical Nuclear Medicine (2023)

We present the case of a 68-year-old woman with a painful tibial tumor and fatigue. Histology and laboratory studies were consistent with a brown tumor secondary to initially unrecognized, severe primary hyperparathyroidism. 18 F-fluorocholine PET/CT revealed a large hypermetabolic parathyroid mass and multiple bone foci considered as brown tumors. Unilateral neck exploration confirmed a large parathyroid adenoma. Serum calcium and parathyroid hormone levels normalized quickly, and symptoms subsided gradually after parathyroidectomy. Brown tumors are a rare complication of severe hyperparathyroidism. 18 F-fluorocholine PET/CT allows the localization of parathyroid adenomas and brown tumors, and can be used as a single imaging modality.
Incidental Detection of Ectopic Ovary Varices by 99mTc–Red Blood Cell Bleeding Scintigraphy in a Patient With Cirrhosis
Authors: Xia Lu, Lijuan Feng, Wei Wang, Jigang Yang
Journal: Clinical Nuclear Medicine (2023)

Abstract A 72-year-old woman with cirrhosis underwent a 99m Tc-labeled red blood cell (RBC) bleeding scan because of recurrent gastrointestinal bleeding. The images showed abnormal 99m Tc-RBC accumulation in a mass in the region of the left ovary. Contrast-enhanced CT showed expansion of left ovary vein from the left renal vein, which twisted into an enhanced round mass in the left ovary area. Finally, a diagnosis of ectopic ovary varices was made, which is secondary to cirrhosis with portal hypertension. Ovary varices should be included as differential diagnoses of 99m Tc-RBC bleeding scintigraphy.
Therapeutic potential of lipid nanosystems for the treatment of Parkinson’s disease
Authors: Subham Preetam, Swathi Jonnalagadda, Lamha Kumar, Rajeswari Rath, Soham Chattopadhyay, Badrah S. Alghamdi, Adel M Abuzenadah, Niraj Kumar Jha, Akash Gautam, Sumira Malik, Ghulam Md Ashraf
Journal: Ageing Research Reviews (2023)
Structurally dynamic self-healable hydrogel cooperatively inhibits intestinal inflammation and promotes mucosal repair for enhanced ulcerative colitis treatment
Authors: Xinyue Ge, Hong Wen, Yang Fei, Rui Xue, Zhuo Cheng, Yanan Li, Kaiyong Cai, Liqi Li, Menghuan Li, Zhong Luo
Journal: Biomaterials (2023)
Quantitative control of Ets1 dosage by a multi-enhancer hub promotes Th1 cell differentiation and protects from allergic inflammation
Authors: Aditi Chandra, Sora Yoon, Michaël F. Michieletto, Naomi Goldman, Emily K. Ferrari, Maryam Abedi, Isabelle Johnson, Maria Fasolino, Kenneth Pham, Leonel Joannas, Barbara L. Kee, Jorge Henao-Mejia, Golnaz Vahedi
Journal: Immunity (2023)
Blue light promotes vitamin C-mediated ferroptosis of melanoma through specifically upregulating transporter SVCT2 and generating Fe2+
Authors: Rong Yang, Fangqing Deng, Yingchun Yang, Qing Tian, Shuaiqi Huangfu, Luqiu Yang, Jing Hou, Guanghao Yang, Wei Pang, Jueru Lu, Hui Liu, Yao Chen, Jie Gao, Lianbing Zhang
Journal: Biomaterials (2023)
Polymeric nanoparticle gel for intracellular mRNA delivery and immunological reprogramming of tumors
Authors: Sarah Y. Neshat, Chun Hei Ryan Chan, Jawaun Harris, Osamah M. Zmily, Savannah Est-Witte, Johan Karlsson, Sydney R. Shannon, Manav Jain, Joshua C. Doloff, Jordan J. Green, Stephany Y. Tzeng
Journal: Biomaterials (2023)
Post-COVID condition in patients with inflammatory rheumatic diseases: a prospective cohort study in the Netherlands
Authors: Laura Boekel, Sadaf Atiqi, Maureen Leeuw, Femke Hooijberg, Yaëlle R. Besten, Rosa Wartena, Maurice Steenhuis, Erik Vogelzang, Casper Webers, Annelies Boonen, Martijn Gerritsen, Willem F Lems, Sander W Tas, Ronald F van Vollenhoven, Alexandre E Voskuyl, Irene van der Horst-Bruinsma, Mike Nurmohamed, Theo Rispens, Gertjan Wolbink
Journal: The Lancet Rheumatology (2023)