tbuckley/cabot-search huggingface dataset:
PI3K integrates the action of insulin and leptin on hypothalamic neurons
Authors: A. W. Xu
Journal: Journal of Clinical Investigation (2005)

Central control of energy balance depends on the ability of proopiomelanocortin (POMC) or agouti-related protein (Agrp) hypothalamic neurons to sense and respond to changes in peripheral energy stores. Leptin and insulin have been implicated as circulating indicators of adiposity, but it is not clear how changes in their levels are perceived or integrated by individual neuronal subtypes. We developed mice in which a fluorescent reporter for PI3K activity is targeted to either Agrp or POMC neurons and used 2-photon microscopy to measure dynamic regulation of PI3K by insulin and leptin in brain slices. We show that leptin and insulin act in parallel to stimulate PI3K in POMC neurons but in opposite ways on Agrp neurons. These results suggest a new view of hypothalamic circuitry, in which the effects of leptin and insulin are integrated by anorexigenic but not by orexigenic neurons.
On Eclecticism
Authors: ROBERT M. SIMON
Journal: American Journal of Psychiatry (1974)

In psychiatry today eclecticism is encouraged by the wide range of therapeutic techniques available, the complex needs of patients, and the many political systems (family, school, job, etc.) in which they are enmeshed. Although it is possible to learn a variety of techniques during and after residency without an integrated theory of eclecticism the practitioner may have difficulty deciding when and how to use them. General systems theory has been suggested as a theoretical basis for eclectic psychiatry, but it has several shortcomings. The author concludes that until an adequate theoretical basis is formulated, eclectic choices must be characterized as "artistic" rather than scientific—a serious limitation in the development of practice.
Loss of Body Fluid Found Constant in Dehydration
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The MIRACLE trial: A randomized, controlled trial comparing green tea extract versus placebo for the prevention of metachronous colon adenomas in a screening population.
Authors: Thomas Jens Ettrich, Julia Stingl, Rainer Muche, Katrin Claus, Baerbel Reiser, Thomas Seufferlein
Journal: Journal of Clinical Oncology (2015)

TPS786 Background: Prevention of colorectal cancer is a major health care issue. After polypectomy there is an increased risk of polyp recurrence and various means of chemoprevention have been tried to prevent this. NSAIDs have been shown to be effective but confer side effects such as gastrointestinal bleeding. Nutraceuticals such as polyphenols from tea plants have demonstrated remarkable therapeutic and preventive effects in molecular, epidemiological and some clinical trials. However, their value in preventing colorectal polyps has not been demonstrated in a large, randomized trial. The beneficial safety profile of decaffeinated green tea extract and accumulating evidence of its cancer preventive potential justify and require, in our view, a validation of this compound for the nutriprevention of colorectal adenoma. Good accessibility and low costs might render this neutraceutical a top candidate for wider use as nutritional supplement in colon cancer prevention. Methods: Randomized, double blinded, placebo-controlled, multicenter trial. After a one month run-in period with verum, 918 patients (age: 50-80 years) who have undergone polypectomy within the last 6 months will be randomized to receive either decaffeinated green tea extract (containing 150 mg epigallocatechin gallate (EGCG) two times daily) or placebo over a period of three years. Primary outcome: Incidence of metachronous colorectal adenomas (tubulovillous, tubular, villous, serrated lesions) at the 3 year follow-up colonoscopy. Secondary outcomes: Occurrences, number, localization, size and histological subtypes of adenomas, frequency of colorectal carcinoma. In addition, genetic and biochemical biomarkers in blood samples and genetic alterations (Ras, B-raf, microRNAs) in tissue samples of adenomas will be analyzed (biobanking subprojects). Additionally, nutrikinetics and nutrigenetics of EGCG and other catechins will be assessed in healthy volunteers. Patient recruitment has started in November 2011. At September 2014, 785 patients were recruited and 651 patients were randomized. We expect the last patient out in Spring 2018. (Trial identifier NCT01360320) Clinical trial information: NCT01360320.
Kawasaki disease in a 28-year-old man
Authors: J. M. Glanzer
Journal: JAMA (1980)

KAWASAKI disease or mucocutaneous lymph node syndrome was first observed in Japanese children in 1961 by Tomisaku Kawasaki, MD, who reported his experience with 50 cases in 1967.<sup>1</sup>The syndrome is described as an acute febrile illness with erythema of the conjunctivae and mucous membrane of the upper respiratory tract, erythema and edema of the hands and feet, polymorphous rash, characteristic desquamation, and usually anterior cervical lymphadenopathy. Since 1975, the Center for Disease Control has confirmed 112 cases of the disease in this country. Although the disease has been believed to occur only in children from infancy to 13 years, recent reports concern young adults.<sup>2,3</sup>It is the authors' opinion that the following case represents Kawasaki disease in a 28-year-old man. <h3>Report of a Case</h3> In July 1978, a 28-year-old man from Cedar Rapids, Iowa, was vacationing in a suburban area in Colorado when he awoke with pain
THE MANIA FOR PROPER NAMES.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ARTHRITIS DEFORMANS.THE REPORT OF A SERIES OF ONE HUNDRED AND TEN CASES FROM THE JOHNS HOPKINS HOSPITAL. (FROM THE CLINIC OF PROFESSOR OSLER.)
Authors: THOMAS McCRAE
Journal: JAMA (1904)

<h3>DIAGNOSIS.</h3> Undoubtedly an essential thing in a correct diagnosis is a knowledge of the fact that arthritis deformans often occurs as an acute polyarthritis, with a sudden onset, and that unless care is taken the condition is especially apt to be regarded as acute articular rheumatism. Here, as is usually the case, knowledge of the possibilities is an essential to correct diagnosis. It may be taken for granted that the advanced stages with the marked characteristic deformity are not likely to be mistaken, but of what value is diagnosis then when the possibility of preventing these later changes is the hoped-for thing? Practically, the study of the diagnosis will be confined to the early stages. The more acute forms have to be diagnosed, especially from acute articular rheumatism, acute gout, acute polyarthritis from other causes (for example, septic conditions, etc.), and gonorrheal arthritis. <h3>Acute Articular Rheumatism.</h3> —There are several features that
Diathermy: Short-Wave Therapy, Inductothermy, Epithermy, Long-Wave Therapy
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Irving Seinfeld, MD, of Brooklyn, Is Not Dead
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemiology of murine typhus in Texas. 1980 through 1984
Authors: J. P. Taylor
Journal: JAMA (1986)

From 1980 through 1984, a total of 200 cases of murine typhus were reported in Texas. All cases were confirmed by the indirect fluorescent antibody assay or latex agglutination test. Patients ranged in age from 1 to 90 years (median, 35 years). Fifty-one percent were female. Seventy-four percent of the patients resided in south Texas. Illness occurred in all months of the year, but 40% of the cases had onset in April, May, or June. Annual incidence increased with age and was higher in Hispanics. Murine typhus continues to be an important public health problem in Texas. (<i>JAMA</i>1986;255:2173-2176)
Adverse Outcomes Associated With Use of Proton Pump Inhibitors and Clopidogrel
Authors: Verena Schneider-Lindner
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myasthenia gravis and penicillamine therapy of rheumatoid arthritis
Authors: T. Bocanegra
Journal: JAMA (1980)

IN RECENT years, penicillamine has become an important drug in the treatment of patients with rheumatoid arthritis. Unfortunately, in approximately 35% of these individuals, severe side effects will develop, requiring withdrawal of the drug therapy.<sup>1</sup> Cutaneous, renal, and hematologic abnormalities are the most commonly recognized untoward effects. Recently, myasthenia gravis associated with penicillamine treatment has been reported.<sup>2</sup>A clear temporal relationship suggestive of a drug-induced effect between this neuromuscular syndrome and the administration of penicillamine and the resolution of symptoms after withdrawal of the drug therapy have been observed in most patients. In this report, we describe a patient whose myasthenic symptoms resolved after discontinuation of the drug treatment but spontaneously recurred six months later. We also discuss the possible mechanisms of penicillamine-induced myasthenia gravis. <h3>Report of a Case</h3> Rheumatoid arthritis developed in a 54-year-old man in 1972. He did well while receiving aspirin until March 1978, when
Book reviews
Journal: Allergy (1988)

Lessof, M. H., Lee, T. H. &amp; Kemeny , D. M. (eds.): Kay, A. B. : Allergy and inflammation. MacInnis, A. J. (ed): Molecular paradigms for eradicating helminthic parasites. Cruse, J. M. &amp; Lewis, R. E., Jr. (eds): The year in immunology 1986–87. Benjamini, E. &amp; Leskowitz, S. : Immunology. A short course. Wahn, U., Seger, R., Wahn, V. (eds.): Pädiatrische Allergologie und Immunologie in Klinik und Praxis.
Error in Letters
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Jogging and coronary artery disease
Authors: L. Resnekov
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Doctors and overpopulation
Authors: J. Guillebaud, J. Barnes, D T Baird, R W Beard, G V P Chamberlain, I D Cooke, K J Dennis, C P Douglas, M G Elder, M Elstein, D V I Fairweather, P W Howie, J Loraine, M C Macnaughton, M Maresh, N Morris, J R Newton, D B Paintin
Journal: BMJ (1986)
Response
Authors: L.-E. HOLM, K. WIKLUND, G. LUNDELL
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Response Get access LARS-ERIK HOLM, LARS-ERIK HOLM Radiumhemmet Karolinska HospitalS-104 01 Stockholm Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar K. WIKLUND, K. WIKLUND Radiumhemmet Karolinska HospitalS-104 01 Stockholm Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar G. LUNDELL G. LUNDELL Radiumhemmet Karolinska HospitalS-104 01 Stockholm Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 9, 3 May 1989, Page 714, https://doi.org/10.1093/jnci/81.9.714 Published: 03 May 1989
Role Of The Major Histocompatibility Complex Class I Antigens In Tumor Growth And Metastasis
Authors: K Tanaka
Journal: Annual Review of Immunology (1988)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
Medical stereotypes.
Authors: C M Harris
Journal: BMJ (1981)

It is proposed that Tertiary Educational Assessment should be made using a Curve-Unifying Paradigm with its Scientific And Ultra-Conservative Experiment Ratio.Central Ranking Evaluation And Marking was used to process examination results, generating the Mean Individual Level Knowledge for the group.The concept of MILK grew from the need to encourage the average examination candidate and with it came the need for a Judgmental Understanding Goal.The results of some candidates required further handling by the addition of Student's Universal Grade Averaging Regimen.
Improved detection of early iron deficiency
Authors: Suzanne McClure, Edward Custer, J. David Bessman
Journal: JAMA (1985)

<h3>In Reply.—</h3> Dr Becker describes the difficulty involved in using transferrin saturation to assess bodystores. We agree that interpretation may be difficult in patients with the anemia of chronic disease, although our experience has been closer to Wintrobe's<sup>1</sup>than Christensen's.<sup>2</sup>However, in our study there were no anemic patients, so this difficulty is unlikely to be a factor. In contrast, the ferritin assay often is falsely elevated in acute inflammation,<sup>3</sup>a common problem in our subjects. Therefore, we chose the transferrin saturation as less likely to have artifacts in our study. None of our subjects had bone marrow examination, which, despite its own technical difficulties, is the gold standard for iron assay. However, of the 37 patients in the last year without Prussian bluestainable marrow iron, 35 had elevated red blood cell distribution width (RDW). Certainly the bone marrow examination will reveal the earliest phase of
Total Exchangeable Potassium and Chloride and Total Body Water in Healthy Men of Varying Fat Content
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BACTERIAL VACCIN THERAY: ITS INDICAIONS AND LIMITATIONS
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal