tbuckley/cabot-search huggingface dataset:
Racial Differences in Chronic Stress/Allostatic Load Variation Due to Androgen Deprivation Therapy in Prostate Cancer
Authors: Nickolas Stabellini, Jennifer Cullen, Justin X. Moore, Lifen Cao, Neeraj Agarwal, Nelson Hamerschlak, Kristin Waite, Alberto J. Montero, Jill S. Barnholtz-Sloan, Avirup Guha
Journal: JACC CardioOncology (2022)
Monkeypox: A global threat to domestic and wild animals – Correspondence
Authors: K. C Nikhil, Jigyasa Rana, Shailesh Kumar Patel, Aditya Agrawal, Kumar Govil, Alok Singh, Megha Katare Pandey, Dhruv Nitinkumar Desai, Sita Prasad Tiwari
Journal: International Journal of Surgery (2022)
Plasticity of the adult human small intestinal stoma microbiota
Authors: Bahtiyar Yilmaz, Tobias Fuhrer, Deborah Morgenthaler, Niklas Krupka, Daoming Wang, Daniel Spari, Daniel Candinas, Benjamin Misselwitz, Guido Beldi, Uwe Sauer, Andrew J. Macpherson
Journal: Cell Host & Microbe (2022)
Linked-Color Imaging Detects More Colorectal Adenoma and Serrated Lesions: An International Randomized Controlled Trial
Authors: Sho Suzuki, Satimai Aniwan, Han-Mo Chiu, Kannikar Laohavichitra, Sakkarin Chirapongsathorn, Takeshi Yamamura, Chen-Ya Kuo, Naohisa Yoshida, Tiing Leong Ang, Takahito Takezawa, Rungsun Rerknimitr, Hideki Ishikawa, Takuji Gotoda
Journal: Clinical Gastroenterology and Hepatology (2022)

Effects of linked-color imaging (LCI) on colorectal lesion detection and colonoscopy quality remain controversial. This study compared the detection rates of adenoma and other precursor lesions using LCI vs white-light imaging (WLI) during screening, diagnostic, and surveillance colonoscopies.This randomized controlled trial was performed at 11 institutions in 4 Asian countries/regions. Patients with abdominal symptoms, a primary screening colonoscopy, positive fecal immunochemical test results, or undergoing postpolypectomy surveillance were recruited and randomly assigned in a 1:1 ratio to either the LCI or high-definition WLI group. The primary outcome was adenoma detection rate (ADR). Secondary outcomes were polyp detection rate, advanced ADR, sessile serrated lesion (SSL) detection rate, and the mean number of adenomas per colonoscopy. The recommended surveillance schedule distribution after trial colonoscopy was analyzed.Between November 2020 and January 2022, there were 3050 participants (LCI, n = 1527; WLI, n = 1523) recruited. The LCI group ADR was significantly higher than the WLI group ADR using intention-to-treat (58.7% vs 46.7%; P < .01) and per-protocol analyses (59.6% vs 46.4%; P < .01). The LCI group polyp detection rates (68.6% vs 59.5%; P < .01), SSL detection rates (4.8% vs 2.8%; P < .01), and adenomas per colonoscopy (1.48 vs 1.02; P < .01) also were significantly higher. However, the advanced ADR was not significantly different (13.2% vs 11.0%; P = .06). Significantly more patients in the LCI group had shorter recommended surveillance schedules than the WLI group (P < .01).Compared with WLI, LCI improved adenoma and other polyp detection rates, including SSLs, resulting in alteration of the recommended surveillance schedule after screening, diagnostic, and postpolypectomy surveillance colonoscopies.UMIN000042432 (https://www.umin.ac.jp/ctr/index.htm).
Orthogonal excitations of lanthanide nanoparticle up/down conversion emissions via switching NIR lights for in-vivo theranostics
Authors: Hongxia Zhao, Yuetong Li, Xiaobo Zhang, Kun Wu, Jiahang Lv, Cheng Chen, Huipu Liu, Zhuangzhi Shi, Huangxian Ju, Ying Liu
Journal: Biomaterials (2022)
Bacterial extracellular vesicle applications in cancer immunotherapy
Authors: Kanika Suri, Anisha D'Souza, Di Huang, Aashray Bhavsar, Mansoor Amiji
Journal: Bioactive Materials (2022)

Cancer therapy is undergoing a paradigm shift toward immunotherapy focusing on various approaches to activate the host immune system. As research to identify appropriate immune cells and activate anti-tumor immunity continues to expand, scientists are looking at microbial sources given their inherent ability to elicit an immune response. Bacterial extracellular vesicles (BEVs) are actively studied to control systemic humoral and cellular immune responses instead of using whole microorganisms or other types of extracellular vesicles (EVs). BEVs also provide the opportunity as versatile drug delivery carriers. Unlike mammalian EVs, BEVs have already made it to the clinic with the meningococcal vaccine (Bexsero®). However, there are still many unanswered questions in the use of BEVs, especially for chronic systemically administered immunotherapies. In this review, we address the opportunities and challenges in the use of BEVs for cancer immunotherapy and provide an outlook towards development of BEV products that can ultimately translate to the clinic.
From protein biomarkers to proteomics in dementia with Lewy Bodies
Authors: Augoustos Tsamourgelis, Peter Swann, Leonidas Chouliaras, John T. O’Brien
Journal: Ageing Research Reviews (2022)

Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative dementia. Despite considerable research progress, there remain gaps in our understanding of the pathophysiology and there is no disease-modifying treatment. Proteomics is a powerful tool to elucidate complex biological pathways across heterogenous conditions. This review summarizes the widely used proteomic methods and presents evidence for protein dysregulation in the brain and peripheral tissues in DLB. Proteomics of post-mortem brain tissue shows that DLB shares common features with other dementias, such as synaptic dysfunction, but retains a unique protein signature. Promising diagnostic biomarkers are being identified in cerebrospinal fluid (CSF), blood, and peripheral tissues, such as serum Heart-type fatty acid binding protein. Research is needed to track these changes from the prodromal stage to established dementia, with standardized workflows to ensure replicability. Identifying novel protein targets in causative biological pathways could lead to the development of new targeted therapeutics or the stratification of participants for clinical trials.
Progress and remaining challenges for cancer control in the Gulf Cooperation Council
Authors: Samar Alhomoud, Saleh Al-Othman, Amal Al-Madouj, Mohamad Al Homsi, Khaled AlSaleh, Khalid Balaraj, Adil Alajmi, Partha Basu, Ali Al-Zahrani
Journal: The Lancet Oncology (2022)
Prevalence of diabetic retinopathy in India stratified by known and undiagnosed diabetes, urban–rural locations, and socioeconomic indices: results from the SMART India population-based cross-sectional screening study
Authors: Rajiv Raman, Joana C Vasconcelos, Ramachandran Rajalakshmi, A Toby Prevost, Kim Ramasamy, Viswanathan Mohan, Deepa Mohan, Padmaja K Rani, Dolores Conroy, Taraprasad Das, Sobha Sivaprasad
Journal: The Lancet Global Health (2022)
Associations between childhood trauma and childhood psychiatric disorders in Brazil: a population-based, prospective birth cohort study
Authors: Andreas Bauer, Graeme Fairchild, Gemma Hammerton, Joseph Murray, Ina S Santos, Luciana Tovo Rodrigues, Tiago N Munhoz, Aluísio J D Barros, Alicia Matijasevich, Sarah L Halligan
Journal: The Lancet Psychiatry (2022)

Childhood trauma is a proposed transdiagnostic risk factor for psychopathology, but epidemiological evidence from low-income and middle-income countries (LMICs) is scarce. We investigated associations between trauma and child psychiatric disorders in a birth cohort in Brazil.
Role of Oral Health, Frailty, and Minimal Hepatic Encephalopathy in the Risk of Hospitalization: A Prospective Multi-Center Cohort of Outpatients With Cirrhosis
Authors: Jasmohan S Bajaj, Jennifer C Lai, Puneeta Tandon, Jacqueline G O'Leary, Florence Wong, Guadalupe Garcia-Tsao, Hugo E Vargas, Patrick S Kamath, Scott W Biggins, Ana Limon-Miro, Jawaid Shaw, Chimezie Mbachi, Michael Chew, Janina Golob Deeb, Leroy R Thacker, K Rajender Reddy
Journal: Clinical Gastroenterology and Hepatology (2022)
Spatiotemporal variation and environmental sensitivity of childhood enteric pathogen infection risk: a Planetary Health approach to predictive modelling and risk mapping
Authors: Josh Colston, Margaret Kosek, Ben Zaitchik, Hamada Badr
Journal: The Lancet Planetary Health (2022)

BackgroundDiarrhoeal disease is a major cause of childhood illness caused by many ecologically sensitive enteropathogens. The bacterium Shigella causes around 64 000 child deaths annually and thrives in warm, moist conditions. Spatiotemporally varying estimates of disease burden are crucial for targeting interventions like the forthcoming phase 2 trials of the Shigella vaccine. We aimed to model and map paediatric Shigella infection risk across low and middle-income countries (LMICs) using covariates with quasi-global coverage.MethodsNational Aeronautics and Space Administration (NASA), Johns Hopkins University, and University of Virginia have been collaborating to compile diagnostic data from multiple sources into a repository of unparalleled size, scope, and diversity. Data were combined from 20 studies that used PCR to diagnose Shigella in stool samples from children younger than 5 years in LMICs, resulting in a pooled database of more than 66 000 samples from 22 000 people in 23 countries. These were matched spatiotemporally to time-varying hydrometeorological variables extracted from historical daily Earth observation-based and model-based estimates derived from re-analysis, environmental and demographic spatial covariates, and household-level and subject-level data. Variable selection was carried out and a predictive projection method was implemented, making predictions separately for three age groups: 0–11 months, 12–23 months, and 24–59 months.FindingsAir temperature was the most influential variable, with infection risk peaking at temperatures of around 34°C (close to that of the human body). The interaction of precipitation with soil moisture also had a strong effect. Accessibility to cities was an influential non-hydrometeorological covariate. The model predicted wide belts of elevated Shigella risk in tropical sub-Saharan Africa, India, and Brazil, and smaller pockets of high prevalence in, for example, New Guinea, Ethiopia, the Sahel, coastal Central America, and Colombia, and others.InterpretationAdvances in differential pathogen diagnosis, climatological modelling, and geostatistical methods now make it possible to generate quasi-global maps of enteric pathogen transmission risk. These predictions will be made publicly available for use in decision making, such as identifying populations in hotspots of Shigella transmission risk that can be prioritised when vaccines become available.FundingNASA's Group on Earth Observations Work Programme (16-GEO16-0047).
Climate–poverty connections: an evidence-based review of climate solutions that generate human benefit
Authors: Yusuf Jameel, Carissa Patrone Maikuri, Kristen P Patterson, Paul West
Journal: The Lancet Planetary Health (2022)

BackgroundAddressing climate change and improving the wellbeing of people facing extreme poverty—two key aspects of planetary health—can and must be complimentary. The objective of this research is to provide decision makers with rigorous and concrete evidence of how climate solutions can also contribute to meeting development and human wellbeing needs in low-income and middle-income countries while improving planetary health.MethodsWe identified 28 solutions (from the 80 climate mitigation solutions that Project Drawdown has previously analysed) with potential to generate human wellbeing co-benefits for rural and under-resourced communities in South Asia and sub-Saharan Africa. We then used Doughnut Economics to develop a rigorous and consistent framework to analyse 12 dimensions of human wellbeing co-benefits generated by the climate solutions. Finally, we synthesised evidence of the human wellbeing co-benefits of the 28 climate solutions.FindingsDrawing on over 450 articles and reports, our landmark analysis shows that climate solutions generate vast direct and indirect co-benefits to human wellbeing, particularly around the domains of income and work, health, food, education, gender equality, and energy. For example, providing clean electricity and adopting clean cooking can address energy poverty and improve networks, health, and gender equality; increase income and work; and boost educational outcomes. In addition, improving agriculture and agroforestry can boost income and food and water security, and provide benefits for education, health, gender equality, and energy. Together, the climate solutions included in the report can prevent or reduce more than 600 gigatonnes of carbon dioxide equivalent between 2020 and 2050, while also boosting socioeconomic development.InterpretationPeople facing extreme poverty are often most vulnerable to climate change, although they are the least responsible for it. Investments in low-carbon development pathways that prioritise communities that are first and worst affected by climate change, particularly in low-income and middle-income countries, are key components of planetary health. In alignment with the Sixth Assessment Report of the Intergovernmental Panel on Climate Change, we must coordinate strategies, complement funding, and harmonise policies to simultaneously address climate change, alleviate poverty, and boost human wellbeing while increasing resilience to current and future climate change. Our analysis shows a remarkable opportunity for decision makers, policy makers, and funders focused on climate change to work alongside women, young people, Indigenous peoples, and local communities to implement climate solutions that could make a drastic difference for the wellbeing of both people and the planet.FundingKing Philanthropies (Menlo Park, CA, USA).
Investigating the contextual factors and mechanisms associated with implementing Blue Prescription Programmes in health and social care settings: a systematic review using realist synthesis
Authors: Julius Cesar Alejandre, Sebastien Chastin, Katherine N Irvine, Michail Georgiou, Preeti Khanna, Zoë Tieges, Niamh Smith, Yong-Yee Chong, Frances Claire Onagan, Lesley Price, Sharon Pfleger, Rachel Helliwell, Judith Singleton, Allan Estandarte, Emily Sophia Smith, Samuel Curran, Karin Helwig
Journal: The Lancet Planetary Health (2022)
ACCELERATE Paediatric Strategy Forums: an advance for oncological drug development?
Authors: Andrew D J Pearson, Teresa de Rojas, Dominik Karres, Gregory Reaman, Nicole Scobie, Elizabeth Fox, Giovanni Lesa, Franca Ligas, Koen Norga, Karsten Nysom, Alberto Pappo, Brenda Weigel, Susan Weiner, Gilles Vassal
Journal: The Lancet Oncology (2022)
Accelerating the integration of China into the global development of innovative anticancer drugs
Authors: Huiyao Huang, Dawei Wu, Huilei Miao, Yu Tang, Chengcheng Liu, Hong Fang, Xinyu Meng, Shuhang Wang, Qi Zhu, Xin Wang, Jingting Du, Zhimin Yang, Ning Li, Binghe Xu, Jie He
Journal: The Lancet Oncology (2022)
Bacterial infection possibly causing autoimmunity: Tropheryma whipplei and membranous nephropathy
Authors: Thorsten Wiech, Linda Reinhard, Sonia Wulf, Alfio Edoardo Giuffrida, Elisa Longhitano, Rosario Caruso, Hermann-Josef Gröne, Rolf A K Stahl, Peter F Zipfel, Judith Kikhney, Annette Moter, Elion Hoxha, Domenico Santoro
Journal: The Lancet (2022)
The effect of cilgavimab and neutralisation by vaccine-induced antibodies in emerging SARS-CoV-2 BA.4 and BA.5 sublineages
Authors: Prerna Arora, Lu Zhang, Inga Nehlmeier, Amy Kempf, Anne Cossmann, Alexandra Dopfer-Jablonka, Sebastian R Schulz, Hans-Martin Jäck, Georg M N Behrens, Stefan Pöhlmann, Markus Hoffmann
Journal: The Lancet Infectious Diseases (2022)
Heat stress and incidence of acute kidney injury among agricultural workers in Spain
Authors: Cristina O'Callaghan-Gordo, Lourdes Arjona, Francisco Brocal, Ben Caplin, Ana Espinosa, Rocío García, Mayte Martín-Bustamante, Claudia Malpica-Lander, Oriana Ramirez-Rubio, Elena Ronda, Neil Pearce, Manolis Kogevinas
Journal: The Lancet Planetary Health (2022)
Liposome cocktail activator modulates hepatocytes and remodels the microenvironment to mitigate acute liver failure
Authors: Na Yin, Wenjun Zhang, Runxiu Wei, Qiang Yang, Fengming He, Ling Guo, Min Feng
Journal: Asian Journal of Pharmaceutical Sciences (2022)

Acute liver failure (ALF) is a mortal and critical hepatic disease, in which oxidative stress, inflammation storm and hepatocyte death are crucial in the pathogenesis. Hence, in contrast to the control of a single link, a combination therapy targeting multiple pathogenic links of the disease will be a favorable means to control the progression of the disease. In this study, we constructed dimethyl itaconate-loaded liposomes modified with dodecyl gallate as a cocktail activator to investigate its functional role in acetaminophen (APAP)-induced ALF. Our results demonstrated that the cocktail activator acted on hepatocytes and triggered cocktail efficacy, thereby simultaneously attenuating APAP-induced hepatocyte damage and remodeling the damage microenvironment. The cocktail activator could effectively scavenge reactive oxygen species, inhibit excessive inflammatory responses and reduce cell death in impaired hepatocytes for detoxification. More importantly, the cocktail activator could remodel the damage microenvironment, thus further promoting hepatocyte expansion and specifically switching macrophages from the M1 to M2 phenotype for a favorable liver regeneration of ALF. Furthermore, in APAP-induced ALF mouse model, the cocktail activator improved liver function, alleviated histopathological damage and increased survival rate. In summary, these findings indicate that the cocktail activator may provide a promising therapeutic approach for ALF treatment as a nanomedicine.
Do informant-reported subjective cognitive complaints predict progression to mild cognitive impairment and dementia better than self-reported complaints in old adults? A meta-analytical study
Authors: Lucía Pérez-Blanco, Alba Felpete, Scott B. Patten, Sabela C. Mallo, Arturo X. Pereiro, María Campos-Magdaleno, Onésimo Juncos-Rabadán
Journal: Ageing Research Reviews (2022)

Background: Subjective cognitive complaints (SCCs) are considered a risk factor for objective cognitive decline and conversion to dementia.The aim of this study was to determine whether self-reported or informant-reported SCCs best predict progression to mild cognitive impairment (MCI) and/or dementia.Methods: We reviewed prospective longitudinal studies of Cognitively Unimpaired (CU) older adults with selfreported and informant-reported SCCs at baseline, assessed by questions or questionnaires that considered the transition to MCI and/or dementia.A random-effects meta-analysis was performed to obtain pooled estimates and 95% CIs.Results: Both self-reported and informant-reported SCCs are associated with an elevated risk of transition from CU to MCI and/or dementia.The association appears stronger and more robust for informant-reported data [1.38, with a 95% CI of 1.16 -1.64, p < 0.001] than for self-reported data [1.27 (95% CI 1.06 -1.534, p = 0.011].Conclusions: Our results suggest that corroborated information from one informant could provide important details for distinguishing between normal aging and clinical states.
Accelerating climate protection by behavioural insights: the Planetary Health Action Survey (PACE)
Authors: Mirjam A Jenny, Lena Lehrer, Sarah Eitze, Philipp Sprengholz, Lars Korn, Parichehr Shamsrizi, Mattis Geiger, Lennart Hellmann, Lisa Mai, Kira Maur, Cornelia Betsch
Journal: The Lancet Planetary Health (2022)
Does living near blue space modify the effect of socioeconomic deprivation on mental health in urban areas: a population-based retrospective study
Authors: Michail Georgiou, Zoë Tieges, Gordon Morison, Niamh Smith, Sebastien Chastin
Journal: The Lancet Planetary Health (2022)

The incidence of mental health disorders in urban areas is increasing and there is a growing interest in using urban blue spaces as nature-based therapy to prevent and manage mental health. However, there is a dearth of longitudinal evidence of the mechanisms and effect of blue spaces on clinical markers of mental health to support and inform such interventions. Restoration of the north Glasgow branch of the Forth and Clyde canal began in 2000 as part of Glasgow's Smart Canal project, which is the largest programme of canal regeneration in the UK. The canal was completely closed and left to dereliction for more than 40 years and the first canal lock reopened as a space for recreation in 2006. Situated within the most deprived neighbourhoods in Europe and characterised by a clustering of environmental and socioeconomic deprivation, physical and mental health challenges, substantial health disparities, and climate change vulnerabilities, this is a unique natural experiment that was primarily developed to increase the communities' resilience to climate change.To investigate the mental health cobenefits deriving from the canal regeneration project, we conducted a population-based retrospective cohort study and explored whether living near blue space modified the negative effect of socioeconomic deprivation on the mental health of the population of north Glasgow, Scotland, using routinely collected NHS data, over a 10-year period (2009-18). We developed two Cox proportional hazards models; a base model estimating the effect of socioeconomic deprivation on mental health and a second identical model with an additional variable of distance to blue space. We then investigated the modifying effect of living near blue space by comparing the effects between the two models.Our findings indicate that living near blue space modified the risk of mental health disorders deriving from socioeconomic deprivation by 6% (hazard ratio [HR] 2·48, 95% CI 2·39-2·57) for those living in the most deprived tertile, and 4% (1·66, 1·60-1·72) for those in the medium-deprivation tertile.The findings of this study support the notion that living near blue space could play an important role in reducing the burden of mental health inequalities in urban populations.The Data Lab (to SC).