tbuckley/cabot-search huggingface dataset:
Prognostic value of ischemic localization on myocardial perfusion SPECT Xingping Kang, Daniel S. Berman, Enrique F. Schisterman, Sean W. Hayes, Howard C. Lewin, James Gerlach, Ishac Cohen, Guido Germano, Raluca D. Agafitei, John D. Friedman. Cedars-Sinai Medical Center, Los Angeles, CA
Journal: Journal of the American College of Cardiology (2001)
Angiomatosis Retinae
Authors: Bradley R. Straatsma
Journal: New England Journal of Medicine (1954)

A UNIQUE feature of military medicine is the opportunity it provides for periodic physical examination of young adults. These examinations offer an unparalleled situation for the diagnosis of asymptomatic disease in this generally healthy group. Detection of retinal abnormalities on routine examination of the ocular fundi led to the diagnosis of the case of angiomatosis retinae reported below.Angiomatosis retinae (von Hippel's disease) is a comparatively rare disease characterized by the presence of one or more hemangioblastomas of the retina and the destructive changes secondary to these tumors. It was first described in 1879 by Panas and Remy1 and thereafter . . .
The Cost-Effectiveness of Sildenafil (Viagra)
Journal: Annals of Internal Medicine (2000)

Summaries for Patients20 June 2000The Cost-Effectiveness of Sildenafil (Viagra)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-12-200006200-00042 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Sildenafil, a drug commonly known by the brand name Viagra, is a treatment for male impotence. Many patients want Viagra, which costs about $5 to $10 per pill, but many insurance companies do not cover the its cost. Cost-effectiveness analysis is a method for determining how much a health treatment costs for a given amount of benefit. The benefit is usually measured in units called quality-adjusted life-years (QALYs). This measure takes into consideration not only how long a person lives but also the quality of their life during ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled "The Cost-Effectiveness of Sildenafil." It is in the 20 June 2000 issue of Annals of Internal Medicine (volume 132, pages 933-937). The authors are K.J. Smith and M.S. Roberts.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Cost-Effectiveness of Sildenafil Kenneth J. Smith and Mark S. Roberts Metrics 20 June 2000Volume 132, Issue 12Page: 933KeywordsAdverse reactionsDrugsErectile dysfunctionMyocardial infarctionQuality adjusted life yearsQuality of lifeSimulation and modeling Issue Published: 20 June 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...
Inhibition of rat hepatic mitochondrial aldehyde dehydrogenase-mediated acetaldehyde oxidation by trans -4-hydroxy-2-nonenal
Authors: David Y. Mitchell, Dennis R. Petersen
Journal: Hepatology (1991)

The hepatic oxidation of ethanol has been demonstrated to cause peroxidation of cellular membranes, resulting in the production of aldehydes that are substrates for hepatic aldehyde dehydrogenases. It was the purpose of this study to evaluate the cooxidation of the lipid peroxidation product, trans -4-hydroxy-2-nonenal, and acetaldehyde by high-affinity mitochondrial aldehyde dehydrogenase, which is of prominent importance in the oxidation of ethanol-derived acetaldehyde. Experiments were performed for determination of kinetic parameters for uninhibited acetaldehyde and 4-hydroxynonenal oxidation by semipurified mitochondrial aldehyde dehydrogenase prepared from male Sprague-Dawley rat liver. The affinity of the enzyme for the substrate at low substrate concentrations and the Michaelis-Menten constant of mitochondrial aldehyde dehydrogenase for acetaldehyde were 25 and 10 times greater, respectively, than those determined for 4-hydroxynonenal. Coincubation of acetaldehyde with physiologically relevant concentrations of 4-hydroxynonenal (0.25 to 5.0μmol/L) with mitochondrial aldehyde dehydrogenase demonstrated that 4-hydroxynonenal is a potent competitive or mixed-type inhibitor of acetaldehyde oxidation, with concentration of 4-hydroxynonenal required for a twofold increase in the slope of the Lineweaver-Burk plot for acetaldehyde oxidation by ALDH of 0.48 μmol/L. The results of this study suggest that the aldehydic lipid peroxidation product, trans -4-hydroxy-2-nonenal, is a potent inhibitor of hepatic acetaldehyde oxidation and may potentiate the hepatocellular toxicity of acetaldehyde proposed to be an etiological factor of alcoholic liver disease. (Hepatology 1991;13:728-734.)
TAPEWORM INFESTATION
Authors: P. S. Kaadt
Journal: JAMA (1927)

<h3>To the Editor:</h3> —The article by Magath and Brown on the "Standardized Method of Treating Tapeworm Infestations" (The Journal, May 14) prompts me to give a method I have used for some time. The preparation of the patient and the search for the head are practically the same as their method, but in administering the drugs I first pass a duodenal tube. When the bulb has left the stomach I inject through the tube an emulsion of 1 cc. of chloroform and 4 cc. of oleoresin of aspidium in 30 cc. of mucilage of acacia. The tube is left in place, and in about an hour the emulsion is followed by a magnesium sulphate solution. The patient does not experience nausea or untoward effects, and the worm is passed in about an hour. I do not know that this is original, but I have never failed to obtain the head
Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography
Authors: Jorma Wartiovaara, Lars-Göran Öfverstedt, Jamshid Khoshnoodi, Jingjing Zhang, Eetu Mäkelä, Sara Sandin, Vesas Ruotsalainen, R. Holland Cheng, Hannu Jalanko, Ulf Skoglund, Karl Tryggvason
Journal: Journal of Clinical Investigation (2004)

The definition of "totipotent" was incorrectly identified as "Cell committed to a specific lineage that is capable of giving rise to all types of differentiated cells and tissues, including extraembryonic tissues."The correct definition is "Cell not committed to a specific lineage that is capable of giving rise to all types of differentiated cells and tissues, including extraembryonic tissues."
Hallucinogenic Substances
Authors: John C. Kramer
Journal: JAMA (1967)

<h3>To the Editor:—</h3> David R. Rubin MD, (<b>201</b>:143, 1967) described some of the effects, techniques of use, and lack of legal control of two hallucinogenic substances, dimethyltryptamine (DMT) and diethyltryptamine (DET). Some comments are in order. On May 27, 1966, former Governor Brown approved an amendment to Section 11901 of the California Health and Safety Code which added LSD, DMT, and their salts and derivatives to the list of "restricted dangerous drugs." The provision that "derivatives" of DMT were included might be interpreted as restricting DET as well. Dr. Rubin indicates that DMT and DET are not effective unless injected intramuscularly or intravenously. In fact, a common way of using these substances is to add one of them to a regular tobacco or marijuana cigarette. As he indicated, the effect, whether by injection or inhalation, is prompt and profound but relatively short in duration. Whether because of some differences
The quality of a medical article. Thank you to our 1990 peer reviewers
Authors: G. D. Lundberg
Journal: JAMA (1991)

How can the quality of an article in a medical journal be determined? In a sense, that is like asking someone to define beauty. As with beauty, quality is in the eye of the beholder. I prefer the definition of the American Society for Quality Control: "Quality is the totality of features and characteristics of a product or service that bears upon its ability to satisfy stated needs." To measure the quality of an individual article we might consider the following: Readership of an article, that is, the number and percentage of those who receive a publication and choose to read an article and then assign a value to it. Letters received by the primary journal praising, condemning, or otherwise commenting on the article. Attention paid to the article by the public media. Frequency and rapidity of citation of the article in references in other articles. The perceived prestige of
CRITICAL CONSIDERATIONS OF EDEMA
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Isolation and molecular characterization of hepatitis B virus X-protein from a baculovirus expression system
Authors: S Urban
Journal: Hepatology (1997)

The X protein (HBx) of the human Hepatitis B Virus (HBV) is a regulatory protein that exercises a transcriptional activator function on a variety of regulatory elements and is therefore considered to be involved in the development of human hepatocellular carcinoma (HCC). So far, most attempts at elucidating HBx function have been undertaken at the genetic level, reflecting the difficulties in detecting the very low amounts of the protein in infected livers. Consequently, the questions of intracellular localization and posttranslational modification have not yet been completely answered. We therefore constructed recombinant baculoviruses that allowed expression of HBx and the hexa histidine HBx fusion protein HBxHis in insect cells. Cell fractionation experiments revealed that only a minor part of HBx is detectable in a soluble form in the cytosolic fraction, whereas most of the protein forms intracellular aggregates. These results could be confirmed by confocal laser immunofluorescence. The fusion of a hexa-histidine tag to the amino terminus of HBx allowed a rapid one-step purification by metal chelate affinity chromatography. The detailed analysis of purified HBxHis using electrospray ionization mass spectrometry uncovered two major components: the unmodified, monomeric, fully oxidized form with five intramolecular disulfide bridges, and its N-acetylated modification. Additionally, two minor peaks with mass differences of Δ m = +80 da suggested that a small fraction of HBx becomes posttranslationally phosphorylated in insect cells. No further modifications could be observed, indicating that only phosphorylation might play a role in a possible posttranslational regulation of this viral activator.
The Problem of Mental Disorder: A Study Undertaken by the Committee on Psychiatric Investigations, National Research Council
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Drugs' Dosages Often Too High
Authors: J. Stephenson
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Headache, St. Louis
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physician-computer interaction as a clinical research technique
Authors: R. S. Cosby
Journal: JAMA (1971)

The technique of physician-computer interaction (PCI) herein described utilizes a clinical data bank for a single disease entity. Physician-computer interaction requires special programming so that the interrelationships of the various clinical and laboratory parameters may be immediately displayed. With use of a data bank composed of 60 variables in each of 500 patients with acute transmural myocardial infarction, the relationships of mortality to coronary care, age, serum glutamic oxabacetic transaminase level, white blood cell count, and congestive failure are illustrated. The technique of physician-computer interaction gives the clinician or researcher an enhanced diagnostic capability, unobtainable by batch processing or standard techniques of statistical analysis. In addition, there is greatly increased opportunity to relate variables in a number of ways. This technique further provides unusual capability in clinical care (individual physician and hospital staff), teaching (self-assessment program), clinical research (examining mortality), and administration.
A Text-Book of Pathology.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CORONARY COMPUTED TOMOGRAPHY ANGIOGRAPHY FOR THE DETECTION OF CARDIAC ALLOGRAFT VASCULOPATHY: A META-ANALYSIS OF PROSPECTIVE TRIALS
Authors: Jorge Romero, Omar Wever-Pinzon, Anjani Golive, Iosif Kelesidis, Carlos Manrique, Stavros Drakos, Ileana Pina, Abdallah Kfoury, Josef Stehlik, Mario Garcia
Journal: Journal of the American College of Cardiology (2014)
Absolute neutrophil count (ANC) pattern with accelerated dose-intensified epirubicin chemotherapy and pegfilgrastim support
Authors: E. Segota, S. Misbah, J. Crowe, R. Tubbs, G. Casey, P. Elson, B. Wacker, G. T. Budd
Journal: Journal of Clinical Oncology (2004)

8229 Background: Several randomized studies evaluating pegfilgrastim and filgrastim have shown no difference in ANC patterns in cycle 2 compared to cycle 1 of chemotherapy. We have observed an interesting ANC pattern in a phase II clinical study evaluating the safety and efficacy of accelerated dose- intensified neoadjuvant epirubicin with pegfilgrastim support in patients with breast cancer. Methods: Biopsy proven stage II/III breast cancer patients with primary tumors >2 cm and adequate hematologic, hepatic, renal, and cardiac function are eligible. Single agent epirubicin is given at 120 mg/m2 every 14 days for four cycles with pegfilgrastim support (6 mg subcutaneously once per cycle 24 hours following each treatment). Definitive surgery is performed 3–4 weeks after completion of chemotherapy. Postoperative therapy is given at the discretion of the investigator. Planned accrual is 30 patients. Results: To date 6 patients have been treated. All 6 have completed chemotherapy, and have undergone surgery. Two patients achieved a clinical complete response, 3 patients had a partial response, and 1 patient has stable disease. Grade 4 neutropenia (ANC<0.5 k/uL) was noted in all 6 patients following cycle 1 of chemotherapy. During cycles 2–4, no grade 4, and only 1 case of grade 3 neutropenia (ANC<0.5 k/uL) was observed in a total of 18 cycles of therapy given (Table). Conclusions: Accelerated, dose intensified epirubicin with pegfilgrastim is safe and appears efficacious as neoadjuvant therapy. The finding of grade 4 neutropenia in all patients after the first dose of epirubicin, but decreased myelosuppression with subsequent chemotherapy cycles suggests a "priming" effect of pegfilgrastim and warrants further study. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Pfizer
A Manual of Pathology.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal