AB0600 ANALYSIS OF RISK FACTORS AND PROGNOSIS IN PATIENTS OF TAKAYASU’S ARTERITIS WITH CORONARY ARTERY LESIONS
Authors: J. Du, L. Pan
Journal: Annals of the Rheumatic Diseases (2022)

Background Takayasu’s arteritis（TA）can involve coronary artery lesions. The pathogenesis is complex and lacks the best treatment strategy.The coronary artery lesions were typical seen in the ostia of the left and right coronary arteries which were major risk factors for sudden death and ischemia heart failure [1-2] .Coronary artery lesions is an important predictor of poor prognosis in TA patients.The incidences of coronary artery lesions were more common in type V TA patients [3-4].The prevalence of metabolic syndrome and its related characteristics (including dyslipidemia, diabetes and hyperinsulinemia) in TA patients are higher compared with healthy people[5].Thus，under the action of vascular inflammation and traditional risk factors, coronary artery stenosis or even occlusion occurs earlier, which can lead to MACE events. Objectives The aim of our study is to investigate the risk factors and prognosis of coronary artery lesions in TA patients. Methods This retrospective study enrolled a total of 120 TA patients.All patients were divided into two groups according to the absence or presence of coronary artery lesions in TA patients (61 vs 59). A logistic model was applied to determine the risk factors associated with the incidence of coronary artery lesions in TA patients.According to the before and after imaging comparison of TA with coronary artery lesions, the influencing factors of improving TA with coronary artery lesions were analyzed. Results The incidence of coronary artery lesions in TA patients increased by 1.618 times for each additional year ( p =0.034, OR1.618,95%CI: 1.036-2.529). History of hyperlipidemia indicated 10.124 fold higher risk of coronary artery lesions in TA patients( p =0.003, OR10.124,95%CI: 2.159-47.483).In the follow-up of TA with coronary artery lesions, 27 patients had coronary CTA results before and after comparison. It was found that 11 patients had remission of coronary artery lesions and 16 patients had no remission of coronary artery lesions. The age in the group with improved coronary imaging was significantly younger than that in the group without improved coronary imaging[（39.00±9.81 vs (47.44±10.06) years, p =0.041)].TNF-α and interleukin-6 were significantly higher in the group with improved coronary imaging than in the group without improved coronary imaging[（26.40(10.08，165.90) vs 7.80(6.73，21.70)pg/dl, p =0.047;12.50(5.83，19.30) vs3.71(2.80，4.40)pg/dl, p &lt;0.001].Numano type V (75.00% vs 27.27%, p = 0.022) and vascular calcification (56.25% vs 9.09%, p = 0.018) were significantly higher than those in the group without improved coronary imaging, while numano type IIb in the group with improved coronary imaging was significantly higher than that in the group without improved coronary imaging(45.45% vs 6.25%， p =0.027). Conclusion Hyperlipidemia and age are the risk factors of coronary artery lesions in Takayasu arteritis.Numano type V and vascular calcification are not conducive to the improvement of TA with coronary artery lesions.All patients with TA of numano type IIb should be screened for coronary artery. Early control of inflammation is more conducive to the imaging improvement of arteritis coronary lesions. References [1]Matsubara, O, Kuwata, T, Nemoto, T, et al., Coronary artery lesions in Takayasu arteritis: pathological considerations, Heart and vessels. Supplement, 1992;7:26-31. [2]Wang H, Liu Z, Shen Z, et al. Impact of coronary involvement on long-term outcomes in patients with Takayasu’s arteritis. Clin Exp Rheumatol 2020;38:1118-26. [3]LiJ,et al.. (2017) Clinical characteristics of heart involvement in Chinese patients with Takayasu arteritis. J Rheumatol 44:1867–1874. [4]Li T, Du J, Gao N, et al. Numano type V Takayasu arteritis patients are more prone to have coronary artery involvement. Clin Rheumatol 2020;39:3439-47. [5]Soto ME, et al..(2011) Coronary CT angiogra- phy in Takayasu arteritis. JACC Cardiovasc Imaging 4(9):958–966 Figure 1. Disclosure of Interests None declared