POS1471-HPR PAIN CATASTROPHIZING AND ITS ASSOCIATION WITH PAIN OF PATIENTS WITH RHEUMATOID ARTHRITIS IN A NON-INFLAMMATORY CONDITION.
Authors: T. Abe
Journal: Annals of the Rheumatic Diseases (2022)

Background Pain in rheumatoid arthritis (RA) is considered to be linked with non-inflammatory factors, including physical disabilities, psychiatric disorders, and pain catastrophizing (PC) (1 . Objectives We investigated the role of PC in the possible link between physical disabilities and psychiatric disorders in RA patients in a non-inflammatory condition. Methods In this cross-sectional study, a total of 81 RA patients in a non-inflammatory condition were included; all patients had serum C-reactive protein levels &lt;0.5 mg/dL, without any inflammatory joints. We examined the demographic and clinical data and administered the pain visual analog scale (VAS), the pain catastrophizing scale (PCS), the Health Assessment Questionnaire Disability Index (HAQ-DI), and the patient version of the Brief Scale for Psychiatric Problems in Orthopedic Patients (pBS-POP). A series of multivariate-adjusted multiple regression analyses were performed to examine the associations between PC and pain intensity, physical disabilities, and psychiatric disorders. Results We found associations between all the above-mentioned variables in separate models associated with HAQ-DI, pBS-POP, and PCS scores. However, in the model associated with pain VAS, the PCS score (β=0.34, p=0.0073) emerged as the only variable showing statistically significant association. Conclusion PC is associated with pain in RA patients in a non-inflammatory condition, and this association may be mediated through pathways involving physical disabilities and psychiatric disorders. References [1]Edwards RR, Giles J, Bingham CO, Campbell C, Haythornthwaite JA, Bathon J (2010) Moderators of the negative effects of catastrophizing in arthritis. Pain Med 11:591–599. Table 1. Multiple linear regression analysis of factors associated with each outcome Outcome Variables ß 95% CI P value Pain VAS Age 0.044 -0.32 to 0.51 0.66 Sex (female) 0.0089 -4.65 to 5.09 0.93 Stage 0.0092 -4.34 to 4.70 0.94 Disease duration 0.19 -0.13 to 0.88 0.14 HAQ-DI 0.23 -0.23 to 1.76 0.13 pBS-POP 0.038 -1.06 to 1.45 0.76 PCS 0.34 0.13 to 0.81 0.0073 pBS-POP Age -0.18 -0.15 to 0.00 0.046 Sex (female) -0.0081 -0.95 to 0.86 0.93 Stage -0.033 -0.97 to 0.71 0.77 Disease duration 0.10 -0.053 to 0.14 0.40 Pain VAS 0.033 -0.037 to 0.050 0.76 HAQ-DI 0.41 0.10 to 0.45 0.0026 PCS 0.31 0.02 to 0.16 0.0088 HAQ-DI Age 0.16 0.01 to 0.20 0.029 Sex (female) 0.14 -0.10 to 2.10 0.93 Stage 0.17 -0.06 to 2.00 0.77 Disease duration 0.22 0.017 to 0.25 0.025 Pain VAS 0.14 -0.01 to 0.09 0.76 pBS-POP 0.29 0.15 to 0.70 0.0026 PCS 0.26 0.03 to 0.19 0.0088 PCS Age -0.10 -0.42 to 0.12 0.27 Sex (female) -0.21 -6.77 to -0.60 0.02 Stage -0.082 -4.10 to 1.83 0.45 Disease duration -0.13 -0.53 to 0.14 0.25 Pain VAS 0.28 0.06 to 0.35 0.0073 pBS-POP 0.30 0.28 to 1.85 0.0087 HAQ-DI 0.36 0.23 to 1.50 0.0080 ß: standardized regression coefficient; CI: confidence interval; HAQ-DI: Health Assessment Questionnaire Disability Index; pBS-POP: the patient version of the Brief Scale for Psychiatric Problems in Orthopedic Patients; PCS: Pain Catastrophizing Scale; VAS: visual analog scale Disclosure of Interests None declared