tbuckley/cabot-search huggingface dataset:
The Electrical Activity of the Nervous System: A Textbook for Students
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Laparoscopic cholecystectomy
Authors: L J Henríquez, R M Belloso, L A Ayala, E A Souchon
Journal: JAMA (1991)

<h3>In Reply.</h3> —The letter by O'Meara states that disulfiram (Antabuse) is rapidly metabolized to two molecules of diethyldithiocarbamate (ditiocarb) and that disulfiram and ditiocarb "are similar in many biologic effects, including the effectiveness in chelation therapy of nickel poisoning and potentiation of hyperbaric oxygen poisoning in rats." In fact, the cited articles<sup>1,2</sup>show that (1) the 100% effective nickel chelation antidotal dose of ditiocarb (50 mg/kg) is one fifth of the 70% effective dose of disulfiram (250 mg/kg); and (2) potentiation of hyperbaric oxygen toxicity in the rat (at three times the human maximum tolerated dose) is 2½ times greater for ditiocarb than for disulfiram (87% vs 30% mortality). The pharmacokinetics of the two drugs are also different. Thus, in contrast to ditiocarb, no detectable serum levels of ditiocarb or its S-methyl ester metabolite can be detected after oral administration of disulfiram (M. Rousseau-Tsangaris, PhD, unpublished data, September 1989).
The Essentials of Roentgen Interpretation
Authors: Luther W. Brady
Journal: JAMA (1973)

In the third edition, the authors have revised the original text to bring up-to-date their book on roentgen interpretation. The new edition makes available a volume bridging the gap between the elementary text and the multiple-volume reference work. It serves as an excellent review source for the practicing physician and surgeon and presents the essentials of roentgenographic interpretation for physicians taking postgraduate training in the specialty of radiology. The new edition presents new research developments in all aspects of roentgenology and carries on the successful format presented in the first two editions. The authors carry on the tradition established in the first two editions with excellent discussions on all methods of radiologic examination used in modern radiology, with a fine organization of the material according to systems, and with illustrations that are carefully chosen and very well reproduced. This reviewer continues to recommend the text enthusiastically. It is a credit
The Silent Epidemic
Authors: Armond S. Goldman
Journal: JAMA (1972)

Burns are occurring in epidemic proportions in the United States. The incidence of burn injuries in the United States exceeds that of every industrialized country, and deaths and crippling due to burns in this country, currently, are considerably greater than the mortality and morbidity due to poliomyelitis in the peak epidemic year of 1954. The impact of burns upon patients and their families is profound. For instance, to save an individual with a 50% burn, intensive treatment in a modern medical facility is required for about four months. However, despite such care, the mortality is about 50%. Furthermore, the cost to salvage a patient with such a life-threatening injury would be at least $36,000. Although a few highly specialized centers have lowered dramatically the mortality for patients with large burns, it is clear that such ideal care will not be available to the majority of burn victims in the near
Ten Years of Operative Surgery in the Provinces
Authors: A. Prichard
Journal: BMJ (1860)

nmorning, by microscopical examination.In two other speci- inens passed later in the day, fatty matter in a molecular form, but no oii-globules, was discovered.Upon standing, a coagu- lum formed in the uirine.These specimens contained about 50 grains of solid matter in 1000 of urine.The patient was a Scotchman, aged ',2.His work was hard, and he was subject to privations.The urine wvas first observed to be thick and white abouLt Chlristmas 1848; and at this time, the chief symptom from which he. suffered, was acute pain in the loins.Lebmann is, as far as I know, the only observer who states that chylous urine never owes its opacity to fat (vol.iii, p. 544).I have now seen several cases, and in all the opacity was due to fatty m-atter.Authorities generally are quite agreed upon this point; but some state that the fat is sometimes in the form of globules.It may be cormbined with albumen.Many of tlhe patients whose cases are recorded, have suffered from severe pain in the region of the kidneys; but this may be accounted for by general debility, associated with this conldi- tion of urine, as well as on the supposition of the existence of organic disease of the k;idneys.Indeed, the pain referred to in this locality, seems to partake more of the character of mus- cular pain than of pain seated in the kidneys themselves.The followiiig are two analyses of the urine in Dr. Bence Jones's case.'The first wvas made on October 19tth, and the .seconldwas passedl some time afterwards, on the same day on which the patient was bled.Analyses 57 53 Water . . .
Ophthalmic Neuromyology. A Study of the Normal and Abnormal Actions of Ocular Muscles from the Brain Side of the Question.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INFANT MORTALITY STATISTICS
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Changes in Marketplace Demand for Physicians
Authors: Sarena D. Seifer
Journal: JAMA (1996)

<h3>Objective.</h3> —To measure trends in marketplace demand for physicians in different specialties. <h3>Methods.</h3> —Retrospective review of physician recruitment advertisements appearing in the September issues of 7 medical journals in 1984,1987,1990,1993, and 1995. <h3>Main Outcome Measure.</h3> —Number of advertised positions in each of the studied specialties. <h3>Results.</h3> —Steep declines in the number of advertised positions for specialist physicians over the past 5 years were consistently observed with the exception of pediatric specialists. The most dramatic changes occurred in the number of internal medicine specialist positions, which declined by 75% since 1990. For physicians as a whole, there were 4 specialist positions for every generalist position advertised in 1990; by 1995, this ratio dropped to 1.8. Family medicine exhibited continuous growth in the number of advertised positions, more than doubling during the period studied. <h3>Conclusions.</h3> —Our data suggest a recent decline in marketplace demand for physicians, particularly those in specialist fields. Among generalists, demand for internists and pediatricians appears to be flat or declining, while demand for family physicians is rising. Ongoing analysis of these advertisements will provide timely information about the demand for physicians in a rapidly changing health care system.
Animal Micrology, Practical Exercises in Microscopical Methods.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapy of Dermatologic Disorders, Including a Guide to Diagnosis and a Dermatologic Pharmacopeia.
Journal: Annals of Internal Medicine (1953)

the differentiation of various disorders; this is the major criticism that the reviewer offers.The book in general can be recommended as an interest- ing and personal discussion of differential diagnosis docu- mented by case histories and reflecting largely continental opinion, although the American point of view is also pre- sented.
INTERMITTENT CLAUDICATION.
Authors: R Jelnes
Journal: JAMA (1900)

Intermittent claudication is a symptom triggered from the musculature during walking. The pathogenesis of the pain is unknown. All patients with peripheral vascular disease must abstain from smoking, perform physical exercise and dietary advice is sometime needed. Reconstructive vascular surgery or percutaneous transluminal angioplasty (PTA) are indicated when the occupational pattern and, in some instances, the recreational activities, are threatened. The results of these treatments are good. For various reasons a number of patients, however, cannot be offered these treatments. These patients must be informed of the importance of physical exercise and discontinuation of smoking. Some of these patients can be offered supplementary medical treatment (e.g. pentoxifylline).
Impact of Proposition 187 Is Difficult to Gauge
Authors: Rebecca Voelker
Journal: JAMA (1995)

FOR Lisa Baumeister, MD, a residency in family practice at San Francisco General Hospital was a natural choice. "The mission statement of the program centered on caring for underserved urban populations," says Baumeister, now in her second year of residency in the hospital's Family Health Center. "I wanted to be in a place that valued immigrant health care and health care for low-income people." In fact, says Baumeister, who is of Mexican descent, advocating for Latinos who often cannot obtain the health care they need was a major motivating force in her decision to enter medicine. "I was raised in Sacramento [Calif], where there is a large Latino community. I developed a deep respect for how the people in the community come together to help themselves and to help build up their community." But since last fall's elections, Baumeister feels some of her goals could be in jeopardy. Voters who
Patients’ Alcohol Drinking Habits in General Practice: Prevention and Education
Authors: P A Shute
Journal: Journal of the Royal Society of Medicine (1988)

A survey of alcohol drinking habits using a questionnaire was conducted in a practice with 2 GPs and 4500 patients. Six hundred and thirty-two questionnaires were completed by all patients aged 15 and over attending the surgery during a three month period. Forty-five patients drinking in excess of 20 units of alcohol per week were identified, 22 of whom submitted to formal interview, examination, haematology, serum biochemistry and an education plan. When 20 of these were followed up after 3 months, 9 claimed to have significantly reduced their alcohol consumption and 10 remembered half or more of the ‘education plan’. As a result of the survey, drinking habits were recorded in the notes of 15% of the practice list and many associated medical problems were recognized for the first time.
Highlights of This Issue
Journal: Clinical Cancer Research (2014)

EGFR-mutations and ALK rearrangements could co-exist in non-small cell lung cancer (NSCLC).To explore the predictive biomarkers in EGFR/ALK co-altered tumors, Yang and colleagues, investigated molecular alterations of EGFR and ALK in a 977-case Chinese cohort and correlated phospho-EGFR and phospho-ALK with responses to EGFR-TKIs and crizotinib.Tumors with such co-alterations could have diverse responses to first-line EGFR TKIs, which were associated with phospho-EGFR levels.Elevated phospho-ALK levels correlated the efficacy of subsequent crizotinib treatment.This study showed the potential utility of receptors phosphorylation status to predict the treatment by EGFR-TKI or crizotinib in EGFR/ALK co-altered NSCLC.
New Demands for Medical Manpower
Authors: Philip R. Lee
Journal: JAMA (1966)

The crisis in American medicine certainly has been diagnosed and treated in a hundred different ways in the last ten years. There is increasing concern that the eye of the storm is health manpower. In a recent series of articles in the<i>Los Angeles Times</i>, the outstanding<i>Times</i>reporter, Harry Nelson, noted as follows: Now that we have Medicare, and other far more revolutionary medical programs are on the horizon, where are we going to get all of the doctors to provide the services? The answer is, that the United States will not have enough doctors for a long, long time, if ever. An affluent society that is becoming increasingly health conscious is making greater demands than the medical and auxiliary health professions can supply. In a few words, Mr. Nelson summarized what I am presenting in more detail. We have a variety of factors influencing the rising tide of
Reconstructing the Past
Authors: Lester S. King
Journal: JAMA (1968)

Most physicians, as well as laymen, enjoy seeing the physical reconstructions of our medical past. Medical antiquarians have achieved remarkable success in finding and collecting the physical aspects of bygone medicine. Various museums the country over have excellent displays, eg, complete reconstructions of physicians' offices or pharmacies, or, on a less ambitious scale, various instruments and other artifacts that indicate our medical heritage. A different way of reconstructing the past involves not the physical or material remnants but rather the concepts, ideas, and intellectual adventures of times past. Through these we reconstruct the world of medical thought rather than the world of medical things. And this, in turn, we may do in one of two ways. We may read what historians say<i>about</i>the old physicians and their concepts, ie, what is ordinarily called "secondary" source material, or we may read the original writings themselves, the "primary" sources of the
Psychiatric Nurse as Therapist
Authors: I. M. Marks, J. Connolly, R. S. Hallam
Journal: BMJ (1973)

Under supervision five nurse-therapists have treated phobic patients as successfully as have psychiatrists and psychologists using similar psychological treatments in comparable psychiatric populations. Nurses have also had good results in other neurotic disorders. Intensive training is required. Nurse-therapists find their work rewarding, but the present Salmon gradings make no provision for their advancement should they retain their clinical function. Results suggest that the use of selected psychiatric nurses as skilled therapists can ease the current critical shortage of treatment personnel in psychiatry.
Hyperviscosity syndrome.
Authors: T Sato, H Sugiyama
Journal: BMJ (1971)

Common clinical manifestations of the hyperviscosity syndrome are bleeding from mucosal membrane, retinopathy, visual disturbance and neurological disorders. These changes can be lethal, and early recognition is important for the proper therapy. Five to 10 percent of patients with multiple myeloma are suffered from the hyperviscosity syndrome because of increased serum viscosity due to the presence of myeloma protein. These patients were currently treated with the combination of plasmapheresis and cytotoxic drugs. Plasmapheresis is known as an efficient method for rapid improvement of the hyperviscosity syndrome, and double filtration plasmapheresis is most commonly used for plasma exchange of multiple myeloma patients in our country. Recent studies have revealed plasmapheresis make blood flow smooth from the standpoint of blood flow dynamics.
Observations on the Transformation of Human Amnion Cell Cultures by Simian Virus 40&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: R. Shihman Chang, T. J. Sinskey
Journal: JNCI Journal of the National Cancer Institute (1968)

Experiments were performed to evaluate the potential of human amnion cell cultures as a tool in the investigation of in vitro transformation of normal human cells. Simian virus 40 (SV40) was the transforming agent used. The amnion cultures were readily transformed by SV40, and the transformed foci were easily recognized. Study of environmental factors that may affect the process of transformation reveals the following positive findings: 1) X irradiation blocks cell transformation but not virus synthesis; 2) hydrocortisone delays the appearance of the transformed foci; 3) some older cultures are more easily transformed than some younger cultures, although a linear relationship between the in vitro age of a culture and its susceptibility to transformation cannot be demonstrated, and 4) overcrowding in a culture also may delay the appearance of transformed foci.
Prognostic Value of Contralateral Renal Plasma Flow in Renovascular Hypertension
Authors: John M. Palmer
Journal: JAMA (1971)

Seventy-one hypertensive patients underwent differential renal function studies with use of urea,<i>p</i>-aminohippurate inulin infusion. All had surgery and 55 had proved unilateral renovascular cause for high blood pressure. Of these, 21 were cured, 20 were improved, and 14 were not affected by the surgical procedures. Cured patients had a mean renal plasma flow (RPF) to the contralateral kidney of 312 ± 24 ml/min. The value was 285 ± 19 ml/min for improved patients and 217 ± 20 ml/min for patients unchanged by surgery. The mean contralateral RPF for cured and improved patients differed significantly (<i>P</i>= 0.01) from that of the failure patients. These differences remained significant when calculated for atherosclerotic patients alone. Although overlap was present, these data will aid in exclusion of atherosclerotic patients of doubtful prognosis from low-yield renovascular surgical procedures.
Mycobacterium marinum Infection
Authors: Joseph P. Bailey
Journal: JAMA (1982)

INFECTION of articular and paraarticular tissue by<i>Mycobacterium marinum</i>is reported infrequently. In a recent review of atypical mycobacterial joint infections,<sup>1</sup>only one was diagnosed and treated without surgery. Even in that case, drug therapy (aminosalicylic acid, isoniazid, and streptomycin sulfate) was considered "empirical" and probably not related to healing.<sup>2</sup>In our case, the diagnosis was made without surgical biopsy, and excellent response was obtained through drug therapy alone. <h3>Report of a Case</h3> A 55-year-old man, previously in good health, sustained a puncture wound over the palmar surface of the second digit of the right hand at the site of the metacarpophalangeal (MCP) joint from a fish fin (red snapper, saltwater fish, nonfrozen). The wound occurred during his work in a meat market and subsequently healed. One week after injury, swelling, erythema, and increased temperature developed on the dorsal surface of the second right MCP joint. Within another
Synthesis and Biologic Evaluation of the Dopamine Analog &lt;italic&gt;N&lt;/italic&gt;-Acetyldopamine in Experimental Leukemia in Mice&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1981)

N-Acetyldopamine is a relatively nontoxic analog of dopamine that has shown significant antitumor activity in experimental L 1210 and P388 leukemias. A convenient two-step chemical synthesis of this derivative provided a sufficient quantity of material to study the effects of the administration of this drug by a more frequent schedule. The antitumor activity in the L 1210 and P388 systems was significantly improved when N-acetyldopamine was administered to (C57BL/6J × DBA/2)F1 (B6D2F1) mice three times daily for 4 days. Long-term survivors appeared, which indicated tumor kills in excess of 105 cells. The effects of dopamine and N-acetyldopamine on the incorporation of radioactively labeled thymidine (dThd) by proliferating tissues (tumor, bone marrow, and gastrointestinal mucosa) were examined in tumor-bearing B6D2F1 mice. The dThd incorporation into tumor cells was selectively inhibited in both the L1210 and P388 leukemias with less inhibition of bone marrow and gastrointestinal mucosa cells. One hour after a dose of 400 mg N-acetyldopamine/kg, dThd incorporation was completely suppressed by both P388 and L1210 tumor cells with minimal effects on bone marrow or gastrointestinal mucosa cells. The synthetic method reported here is applicable to the preparation of various derivatives for study.