tbuckley/cabot-search huggingface dataset:
Needed Developments
Authors: Frederick C. Robbins
Journal: Annals of Internal Medicine (1978)

III. Comments1 November 1978Needed DevelopmentsFrederick C. Robbins, M.D.Frederick C. Robbins, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-5-865_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVaccination is rarely effective in the young infant since the immature host doesn't respond. An area of research that may need more emphasis is the exploration of the mechanism of action of adjuvants and other methods to make vaccines more effective in the young infant. Also, there are certain conditions—and streptococcal B infection of the neonate is a good example—where immunization of the pregnant mother may be a much better answer than trying to immunize the child.I have heard no mention of the proposed legislation that concerns the creation of two new institutes (Institute of Health Statistics and Epidemiology... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Frederick C. Robbins, M.D.Affiliations: Case Western Reserve School of Medicine PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1978Volume 89, Issue 5_Part_2Page: 865-865KeywordsEpidemiologyHealth statisticsInfantsLegislationPediatric infectionsPregnancyStreptococcal infectionsVaccines ePublished: 1 December 2008 Issue Published: 1 November 1978 PDF downloadLoading ...
Treatment of low-renin essential hypertension. Comparison of spironolactone and a hydrochlorothiazide-triamterene combination
Authors: J. G. Douglas
Journal: JAMA (1974)

Seventeen patients with low-renin essential hypertension were studied in a double-blind comparison of the antihypertensive effect of spironolactone with that of a hydrochlorothiazide-triamterene combination. All 17 patients responded to spironolactone. The decrease in average mean blood pressure was 20.7 mm Hg accompanied by an average diuresis of —3.1 kg. Fourteen of the 17 patients had favorable responses to hydrochlorothiazide-triamterene. The average decrease in mean blood pressure was 17.0 mm Hg, and the average diuresis was —1.5 kg. The difference in mean blood pressure response was not statistically significant. The fact that both forms of therapy were effective, even though their mechanisms of action differ, suggests that extracellular fluid volume reduction may be the key factor in the amelioration of hypertension in patients with "low-renin essential hypertension."
Hyponatremia
Authors: Horacio J. Adrogué, Nicolaos E. Madias
Journal: New England Journal of Medicine (2000)

Hyponatremia is defined as a decrease in the serum sodium concentration to a level below 136 mmol per liter. Whereas hypernatremia always denotes hypertonicity, hyponatremia can be associated with low, normal, or high tonicity.1,2 Effective osmolality or tonicity refers to the contribution to osmolality of solutes, such as sodium and glucose, that cannot move freely across cell membranes, thereby inducing transcellular shifts in water.3 Dilutional hyponatremia, by far the most common form of the disorder, is caused by water retention. If water intake exceeds the capacity of the kidneys to excrete water, dilution of body solutes results, causing hypo-osmolality . . .
MASSACHUSETTS SANITARY EXHIBIT.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allied health education and accreditation
Authors: H. L. Hedrick
Journal: JAMA (1983)

<h3>COOPERATION AMONG THE HEALTH PROFESSIONS</h3> For the past 50 years, the American Medical Association has participated extensively in activities to promote quality in allied health education and in accreditation review processes. In collaboration with the AMA, more than 40 allied health organizations and related medical specialty societies have developed educational standards for 25 allied health professions (Appendix IV, Table 1). Using these standards, the Committee on Allied Health Education and Accreditation (CAHEA) accredits more than 3,000 allied health educational programs (Table 1) at almost 1,800 institutions, including hospitals and clinics, junior-community colleges, colleges and universities, and other institutions throughout the United States (Appendix IV, Table 2; and the Figure). Central to the development of quality within allied health educational programs are the<i>Essentials</i>, ie, the minimum acceptable standards for entry-level education. The AMA cooperates with the collaborating organizations in developing and adopting<i>Essentials</i>. In December 1976, the AMA House of
CEREBRAL CONCUSSION
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract TMEM-034: THE HEAT SHOCK TRANSCRIPTION FACTOR HSF1 INDUCES OVARIAN CANCER EPITHELIAL-MESENCHYMAL TRANSITION IN A 3D SPHEROID GROWTH MODEL
Authors: Trillitye Paullin, Chase Powell, Chris Menzie, Robert Hill, Christopher Martyniuk, Sandy D. Westerheide
Journal: Clinical Cancer Research (2017)

Abstract Ovarian cancer is the most lethal gynecological cancer, with over 200,000 women diagnosed each year and over half of those cases leading to death. These poor statistics are related to a lack of early symptoms and inadequate screening techniques. This results in the cancer going undetected until later stages when the tumor has metastasized through a process that requires the epithelial to mesenchymal transition (EMT). In lieu of traditional monolayer cell culture, EMT and cancer progression in general is best characterized through the use of 3D spheroid models. Compared to other cancers, ovarian cancer has very limited treatment options to date, with cisplatin and paclitaxel being the most common and efficient. Recently, a significant increase in heat shock factor 1 (HSF1) expression has been found in highly malignant ovarian cancer. HSF1 is the regulator of the heat shock response (HSR) and promotes the transcription of heat shock proteins (HSPs). Previous studies have shown that HSF1-induced chaperone activity may act to stabilize multiple oncogenes within many different cancer types. This leads to cancer proliferation, reduced apoptosis, and metastasis. In this study, we examine gene expression changes through microarray analysis in spheroid versus monolayer ovarian cancer cells treated with TGFβ to induce EMT. Interestingly, EMT and stress response pathways, including the heat shock response, were all significantly affected by 3D growth. HSF1 knockdown was utilized in both 2D and 3D cultures to further study this response. HSF1 knockdown is shown to inhibit ovarian cancer progression in both monolayer and spheroid model cells. Moreover, HSF1 knockdown in spheroid cells has a significantly greater impact on EMT markers than it does in 2D cultures. This indicates HSF1 may be a utilized as a target for chemotherapeutics in ovarian cancer patients and could potentially have implications in other such hormonal cancers. Citation Format: Trillitye Paullin, Chase Powell, Chris Menzie, Robert Hill, Christopher Martyniuk, and Sandy D. Westerheide. THE HEAT SHOCK TRANSCRIPTION FACTOR HSF1 INDUCES OVARIAN CANCER EPITHELIAL-MESENCHYMAL TRANSITION IN A 3D SPHEROID GROWTH MODEL [abstract]. In: Proceedings of the 11th Biennial Ovarian Cancer Research Symposium; Sep 12-13, 2016; Seattle, WA. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(11 Suppl):Abstract nr TMEM-034.
Holistic Medicine
Authors: O. P. Friedlieb
Journal: JAMA (1979)

<h3>To the Editor.—</h3> The editorial "Holistic Health or Holistic Hoax?" once again brings to mind a pet peeve—a grievance that for some reason our profession has not seen fit to voice loud and clear. It is this: Where in the name of everything holy does it say that a physician is to be more than a healer of sickness? And why have we as a profession allowed ourselves to be placed in such a defensive posture when "accused" of limiting our activities to attempting to diagnose and treat illness? Lord knows it is a worthwhile cause, a most difficult and demanding task, and an honorable living. Why in the world are we expected to be all things to all people and take care of all of everyone's problems? And why, worst of all, do we as a profession go about in sackcloth and ashes, beating our breast, and crying "mea
Working mothers
Authors: Rajashree Ray
Journal: BMJ (2007)

We welcome your rapid responses, whether in direct response to an article in Career Focus or as a way of sharing your own ideas. As long as it isn9t libellous or offensive, we9ll post it on our website. We print a selection of rapid reponses here and the writer of the best each month wins an <i>Oxford Handbook</i> of their choice. Letter of the month prize is donated by OUP.
The Alleged Presence of Bile Salts in Blood
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deferasirox in the Treatment of Iron Overload during Myeloproliferative Neoplasms (MPN)
Authors: Raffaele Porrini, Alessia Campagna, Marianna De Muro, Malgorzata Trawinska, Ambra Di Veroli, Sabrina Leonetti Crescenzi, Luca Petruccione, Atelda Romano, Ada D'Addosio, Angela Rago, Marco Montanaro, Alessandro Andriani, Pasquale Niscola, Enrico Montefusco, Massimo Breccia, Giuliana Alimena, Roberto Latagliata, Agostino Tafuri
Journal: Blood (2016)
Child Abuse
Authors: Edward W. Collins
Journal: JAMA (1983)

The number of publications on child abuse seems to have paralleled the increase in identification of this problem. Many are well intentioned but for the most part are tedious compendiums of how to recognize and perhaps treat abuse. This anthology, whose editor is well known for his activity in the field, could have joined the list but through a freshness in approach and content stands out. Although each chapter has merit of its own, the book is organized from the multidisciplinary perspective, the contemporary and probably most effective method of dealing with the management of abuse and neglect. At the outset the editor charges the reader. How is the quality of life in a society judged? By how well it cares for its children is the response offered, and in the first chapter Michael Robbin takes the reader on a historical tour of the struggle between the rights of children
Renal Origin of Malignant Hypertension
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IMAGING 1-4 HOURS FOLLOWING INJECTION OF INDIUM OXINE LABELED LEUKOCYTES IS NOT SENSITIVE FOR DETECTING OCCULT INFECTION.
Authors: F. Datz, J. Jacobs, N. Alazraki, W. Baker, W. Landrum, A. Taylor
Journal: Clinical Nuclear Medicine (1983)

Datz, F.; Jacobs, J.; Alazraki, N.; Baker, W.; Landrum, W.; Taylor, A. Author Information
Manipulation of Human Ovarian Function: Physiological Concepts and Clinical Consequences
Authors: B. C. J. M. Fauser
Journal: Endocrine Reviews (1997)

I. Introduction II.Dynamics of Normal Human Follicle Growth and Selection A. Gonadotropin-independent and -dependent follicle growth B. Intrafollicular endocrine changes C. Are estrogens needed for follicle development?D. In vivo regulation of follicle maturation in the monkey E. The FSH threshold and window concept for in vivo follicle growth 1.FSH threshold and follicle recruitment 2. FSH window and single dominant follicle selection 3. Dominant follicle development F. Modulation of FSH action 1.Heterogeneity of FSH 2. Direct interference with FSH action 3. Intraovarian interference with FSH action by growth factors III.Gonadotropin Induction of Ovulation A. The concept of monofollicle growth in anovulatory patients B. Conditions affecting treatment outcome 1. Patient-related factors 2. Hormone preparation-related factors 3. Other factors involved C. Commonly used step-up dose regimens 1. Conventional step-up protocol 2. Low-dose, step-up protocol D. Potential for a step-down dose regimen IV.Steroid Contraception and Residual Ovarian Activity A. The concept of follicle growth during partial and transient suppression of circulating FSH B. Ovarian suppression during steroid contraception 1. Significance of initiation of pill intake and duration of treatment 2. Comparison of different steroid doses, compounds, and regimens 3. Pill-free interval and pill omission C. Follicle growth dynamics during steroid contraceptive regimens D. Alternative strategies for contraceptive development V.
"Negative Correlation," Not "No Correlation."
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
STOOLS AND THEIR RELATION TO THE FEEDING IN INFANTS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Balloon tamponade vs. endoscopic sclerotherapy in the management of active variceal hemorrhage
Authors: Josep Terés
Journal: Hepatology (1989)

Sengstaken-Blakemore tamponade is used for the initial control of bleeding esophageal varices (BEV), although it is known to be potentially dangerous. Sclerotherapy has been shown to be effective in the treatment of BEV. This trial has been designed to evaluate comparatively the effectiveness of both procedures in the initial control of the hemorrhage. Forty-three patients with BEV were included in the trial. Twenty patients (group SB) were treated by tamponade. Twenty-three patients (group ST) were treated by sclerotherapy by means of a simple technique. During the first 24 hours, hemostasis was obtained in 16 of the SB patients and in all 23 of the ST patients (p &lt; 0.05). At seven days, nine SB patients and 19 ST patients were free of hemorrhagic relapse (p &lt; 0.05). By stratifying in relation to hepatic failure, the difference was greater (p &lt; 0.005) if patients with Child’s A classification were excluded. It is concluded that sclerotherapy should be undertaken in almost every instance at the same moment that diagnosis is made, bypassing the intermediate step of tamponade.
Water Pollution and Human Health in China
Authors: Changhua Wu, Crescencia Maurer, Yi Wang, Shouzheng Xue, Devra Lee Davis
Journal: Environmental Health Perspectives (1999)

China's extraordinary economic growth, industrialization, and urbanization, coupled with inadequate investment in basic water supply and treatment infrastructure, have resulted in widespread water pollution. In China today approximately 700 million people--over half the population--consume drinking water contaminated with levels of animal and human excreta that exceed maximum permissible levels by as much as 86% in rural areas and 28% in urban areas. By the year 2000, the volume of wastewater produced could double from 1990 levels to almost 78 billion tons. These are alarming trends with potentially serious consequences for human health. This paper reviews and analyzes recent Chinese reports on public health and water resources to shed light on what recent trends imply for China's environmental risk transition. This paper has two major conclusions. First, the critical deficits in basic water supply and sewage treatment infrastructure have increased the risk of exposure to infectious and parasitic disease and to a growing volume of industrial chemicals, heavy metals, and algal toxins. Second, the lack of coordination between environmental and public health objectives, a complex and fragmented system to manage water resources, and the general treatment of water as a common property resource mean that the water quality and quantity problems observed as well as the health threats identified are likely to become more acute.
Correction
Journal: BMJ (1960)

Swelling of Extremities After Alcohol Q.-What could be the cause of swelling of the feet and fingers in an otherwise fit young woman about 10 minutes after taking even a small amount of alcohol ?Her feet tend to swell in very hot weather, but not from other causes.A.-It is likely that the cause in an otherwise fit patient is a simple allergy, possibly related to local vasodilatation.There are, however, a number of pathological conditions in which undue sensitivity to alcohol is recognized.Patients with malignant lymphomata, particularly of the Hodgkin's variety, sometimes complain of considerable pain after consumption of alcohol.' Hypersensitivity has also been noted in carcinoid tumours,2 and other features such as flushing, gastrointestinal, and cardio-respiratory symptoms would support this diagnosis.Finally, sensitivity to alcohol as well as to drugs such as barbiturates can occur in porphyria.The last two conditions may be excluded by biochemical examination of the urine for metabolic products of serotonin and for porphobilinogen respectively.