tbuckley/cabot-search huggingface dataset:
Enhanced Cloning Efficiency of Murine Rhabdomyosarcoma Cells After Chlorozotocin Treatment: Relationship With Enhanced Lung Metastasis
Authors: Catherine Pauwels, Jean-Louis Rebischung, Claude Jasmin, Marie-France Poupon
 4
Journal: JNCI Journal of the National Cancer Institute (1985)

The effect of chlorozotocin [(CZT) CAS: 54749-90-5; 2-(3-(2-chloroethyl)-3-nitrosoureido)-d-gluco-pyranose] was studied on a series of tumor cells, cultured or extracted fresh primary or transplanted tumors, by means of clonogenic assay. The ability of most rat rhabdomyosarcoma cells to form colonies in soft agar was enhanced when exposed to the water-soluble nitrosourea chloride CZT. The tumor cells tested were derived from a) several primary tumors induced in WAG rats by colloidal nickel, then cultured and exposed to CZT early during in vitro passage; b) the 9-4 tumor, also Ni-induced but maintained in long-term culture; and c) the Ni-induced 9-4/0 tumor, maintained by transplantion in syngeneic rats. No inhibition of colony formation was observed in any of the cell lines even at high concentrations of CZT. Adriamycin, chosen as a control treatment, strongly inhibited the cloning efficiency (CE) of the tumor cells. In vivo, the weekly injection of 10 mg CZT Ikg body weight into syngeneic rats bearing transplanted tumors led to an enhancement of lung metastasis formation. The CZT enhancement of CE of tumor cells and its relationship to increased in vivo tumor metastasis is discussed.
Bronchoscopy, Esophagoscopy and Gastroscopy: A Manual of Peroral Endoscopy and Laryngeal Surgery
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights of This Issue
Journal: Clinical Cancer Research (2011)

Klotho is a transmembrane protein that can be shed and act as a circulating hormone.Here, Abramovitz and colleagues explored the expression and function of klotho in pancreatic cancer.They found that klotho expression was reduced in human pancreatic adenocarcinoma.Treatment with klotho or with KL1 internal repeat effectively slowed the growth of pancreatic cancer cells in vitro and in vivo and inhibited activation of the IGF-1 and FGF pathways.These findings indicate that klotho acts as a tumor suppressor and suggest that klotho may be used therapeutically or as a diagnostic marker in pancreatic cancer.
Long-term Silicone Implant Arthroplasty
Authors: Robert M. Nalbandian
Journal: JAMA (1983)

An examination of host tissue response to implanted material has been conducted as part of a comprehensive research program to study lowmodulus of elasticity silicone implants for small-joint arthroplasty. This was performed on animals and in a long-term human clinical evaluation. Autopsy material on three dogs was obtained more than ten years after silicone implants were placed in their limbs, and in one human arthritic patient it was obtained 12 years after hand reconstruction with implants. The benign nature of the tissue reaction to the implant material is noted. It is compared with other implant materials and discussed in terms of host tissue reactions that may occur in joint replacement procedures. (<i>JAMA</i>1983;250:1195-1198)
Highlights of This Issue
Journal: Clinical Cancer Research (2011)

Bortezomib is the first proteasome inhibitor approved for the treatment of cancer.The determinants of resistance to bortezomib, however, remain poorly defined.Here, Weniger and colleagues used gene expression profiling to investigate the cellular response to proteasome inhibition in mantle cell lymphoma.They found that induction of a strong NRF2-regulated antioxidant response in tumor cells during bortezomib treatment identified patients with superior clinical response.In contrast, high basal antioxidant capacity was associated with a reduced stress response and inferior clinical outcome.These results indicate that high cellular antioxidant capacity contributes to bortezomib resistance and may represent a therapeutic target.
Endoscopy International Open – recently published
Journal: Endoscopy (2018)

Comment on: Acetic acid-guided biopsies in Barrett’s surveillance for neoplasia detection versus non-targeted biopsies (Seattle protocol): A feasibility study for a randomized tandem endoscopy trial. The ABBA study Endosc Int Open 2018; 06(01): E43-E50DOI: 10.1055/s-0043-120829 Comment on: Risk of colonic diverticular rebleeding according to endoscopic appearanceEndosc Int Open 2018; 06(01): E36-E42DOI: 10.1055/s-0043-122494 Comment on: Endoscopic ultrasound guided needle-based confocal laser endomicroscopy in solid pancreatic masses – a prospective validation studyEndosc Int Open 2018; 06(01): E78-E85DOI: 10.1055/s-0043-121987
Physicians Face New Contradictions in HIV Care
Authors: Rebecca Voelker
Journal: JAMA (1997)

THE LIFE-EXTENDING properties of protease inhibitors have created a clinical paradox for physicians treating patients infected with the human immunodeficiency virus (HIV). Many patients who are taking combination therapy that includes a protease inhibitor are experiencing fewer opportunistic infections (OIs), even if they don't have a substantial increase in CD4 T cells. At the same time, however, physicians are diagnosing new OIs in patients who have had more marked increases in CD4 cell counts. "We're seeing 2 seemingly contradictory things," Lisa Capaldini, MD, said during the 9th National AIDS Update Conference in San Francisco, Calif. "People with low T cells are getting these infections a lot less. But people who have gone from very low to higher T cells still seem to be at some risk." So where does that leave physicians who must help their patients decide on prophylaxis for OIs? Capaldini, an internist in private practice in San
Immunohistochemical study of alpha, mu and pi class glutathione S transferase expression in malignant melanoma
Authors: A. MORAL, J. PALOU, A. LAFUENTE, R. MOLINA, J. PIULACHS, T. CASTEL, M. TRIAS
Journal: British Journal of Dermatology (1997)

Human pi, mu and alpha class glutathione S transferases (GST) have been localized immunohistologically in normal skin, naevi and melanoma. Pi GSTs were found principally in the stratum basalis and, to a lesser extent, in the superficial layers. Normal melanocytes showed strong nuclear and cytoplasmatic staining. Distribution of GST mu in the epidermis showed that only the stratum basale, where melanocytes are located, stained well but with weak nuclear staining. Normal melanocytes were also well stained. The alpha GSTs were relatively abundant in the upper strata and to a lesser extent, in the basal layers. The absence of nuclear staining gives these cells a target appearance. Normal melanocytes showed strong cytoplasmatic staining. The pi GSTs seem to be most persistently and strongly expressed in malignant melanoma (MM), but mu GSTs are also found, whereas the alpha GSTs were only occasionally present. The finding of the GST mu in the melanocytes of the basal layer raises new questions regarding the role of GST mu in these cells because of the inherent risk of MM in individuals with a congenital deficiency of this isoenzyme. The role of GSTs in the resistance of cells to chemotherapy is also discussed.
Computer guides facial reconstruction
Authors: Beverly Merz
Journal: JAMA (1983)

Holding a light pen, an aeronautical engineer begins to draw over a diagram illuminated on a video screen at McDonnell Douglas Corporation in St Louis. Slowly, a revised picture begins to take shape. But what emerges is not a part for high-performance aircraft. Instead the engineer is using the equipment to simulate craniofacial surgery. By rearranging sections of bone on a computerized three-dimensional (3-D) image of a skull, he is giving a normal appearance to the cranium of a child with a severe congenital anomaly. The engineer at the video console is Jim Warren, a unit director at McDonnell Douglas. His unlikely involvement in reconstructive surgery is the outgrowth of a collaboration with Michael Vannier, MD, assistant professor of radiology, and Jeffrey L. Marsh, MD, professor of plastic and reconstructive surgery, Washington University School of Medicine, St Louis. Together, under the auspices of the university's Edward Mallinckrodt Institute of Radiology,
Models in Medical Research
Authors: Julia T. Apter
Journal: JAMA (1966)

In these few words,<sup>1</sup>the eminent 19th-century physicist described the value of models as a research tool in the physical sciences. Mathematical biologists<sup>2</sup>have demonstrated their acceptance of Maxwell's advice by using models for simplifying and reducing biological data to forms easier for "the mind" to "grasp" so that the next logical step in an investigation may be more readily recognized. The simple analogue model "muscle is a motor" is the subject of this essay. The aim is to explain the successful uses of this model for the three types of muscle<sup>3-6</sup>at three levels of structural organization (organ,<sup>3</sup>individual muscles,<sup>4</sup>and constituent molecules<sup>5,6</sup>). In all the examples selected for discussion, the physical concept "motor" was substituted for the physiological concept "muscle." "Muscle is a motor" serves as a model not only because essential features of muscle are matched but because more readily manipulable material
Vertebral Hemangioma
Authors: ARVIS G. WILLIAMS, FRED A. METTLER
Journal: Clinical Nuclear Medicine (1985)

Radionuclide bone (Tc-99m HDP) and marrow (Tc-99m SC) imaging demonstrated decreased activity in the L-4 vertebral body in a patient with known endometrial carcinoma. Plain radiographs and a CT scan of the lumbar spine demonstrated the typical findings of a vertebral body hemangioma.
Continuing Medical Education: The Infinite Phase of the Continuum
Authors: Marvin E. Johnson
Journal: JAMA (1980)

The sharp differences of opinions that are emerging about the subjects of continuing medical education (CME), recertification, and reregistration of a physician's license may be partially rooted in the differences of opinion concerning what constitutes a continuum of education. Perhaps the dictionary itself is contributing to the misunderstandings.<i>Webster's New Collegiate Dictionary</i>gives as the first definition of the word continuum the following: 1: something absolutely continuous and homogenous of which no distinction of content can be affirmed except by reference to something else (as duration and extension). The advocates of a continuum of education in which the undergraduate, graduate, and CME segments look exactly alike are apparently taking this definition literally. The basic format suggested for each of these three traditional educational periods would contain much formalized learning followed by periodic written examinations, which serve as a short-term disciplinary function and as a long-term gate to allow or prevent
Severe Hypertension and Lithium Intoxication
Authors: Joseph Michaeli
Journal: JAMA (1984)

<h3>To the Editor.—</h3> Although lithium salts have become valuable psychopharmacotherapeutic agents, their use is limited by numerous adverse effects.<sup>1</sup>In a survey<sup>2</sup>of 123 patients with lithium intoxication, mild hypertension was reported in only two patients. We wish to describe a patient with severe hypertension that occurred during acute lithium intoxication. <h3>Report of a Case.—</h3> A 36-year-old woman with long-standing manic depression was hospitalized because of worsening of her depression. During previous admissions and in the course of two pregnancies she had been normotensive. At the time of admission she was receiving lithium carbonate, 1,200 mg daily; therapy had been started three months earlier. Admission BP was 110/55 mm Hg, and her plasma lithium level was 0.5 mmole/L (therapeutic range, 0.5 to 1.5 mmole/L). Because of her psychiatric deterioration, the lithium dose was doubled to 2,400 mg. One week later, the patient became confused, dysarthric, and ataxic and
Physicians' Feelings About Themselves and Their Patients
Authors: Simon Auster
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The American Hospital of the Twentieth Century. A treatise on the development of medical institutions, both in Europe and in America, since the beginning of the present century.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hereford Hospital Prescribing Study: Description and Usefulness<sup>1</sup>
Authors: J W Barnett, A W Alexander, J P Hutchby, J P Wood, B Bond, D W Young
Journal: Journal of the Royal Society of Medicine (1981)

The mode of operation of a computer-based information system designed to link information about drug usage to diagnostic data is described. Details of the cost of this system are given. It is shown that the running costs are approximately £20000 per year. Examples are given of the uses made of the data collected.
Improvement in AIDS Case Reporting, South Carolina
Authors: Jeffrey L. Jones
Journal: JAMA (1991)

<h3>To the Editor. —</h3> Earlier this year we commented in a letter toThe Journal<sup>1</sup>about the reporting of acquired immunodeficiency syndrome (AIDS) cases in South Carolina before the state implemented an active surveillance program (previous to July 1987). In the 18-month study period prior to an active surveillance program, Conway et al<sup>2</sup>found 59.5% reporting of AIDS cases. We have completed an analysis of AIDS case reporting in the subsequent 18 months during which active surveillance was started in South Carolina (July 1, 1987, through December 31, 1988), using the same methodology as Conway et al, a computerized search of a statewide hospital discharge database combined with chart review. During this 18-month period, 181 cases identified on the statewide hospital discharge database met the 1987 Centers for Disease Control AIDS case definition. Of the 181 cases, 159 (88%) had been reported to the South Carolina AIDS registry
Biological and Metabolic Effects of Nitrosomethylurea and Nitrosomethylurethan<xref ref-type="fn" rid="FN2">2</xref>
Authors: Herbert S. Rosenkranz, Minda Bitoon, Robert M. Schmidt
Journal: JNCI Journal of the National Cancer Institute (1968)

Nitrosomethylurea and nitrosomethylurethan devitalize Escherichia coli. This lethal event is accompanied by an inhibition of DNA synthesis and a degradation of cellular DNA. The lethal action of these drugs is prevented by sodium azide, but not by specific inhibitors of RNA, DNA, or protein synthesis. The similarity in the action of the two drugs was confirmed by the discovery that a bacterial mutant resistant to nitrosomethylurethan was cross-resistant to nitrosomethylurea. Contrary to expectations, the action of these drugs was not entirely similar to that of other monofunctional alkylating agents as determined by biochemical and bacteriological techniques.
Defense Appears to Have Advantage Over Offense Presently in Biological Warfare
Authors: Charles Marwick
Journal: JAMA (1991)

AMONG THREATS associated with modern warfare is potential use of biological or chemical weapons. Nowhere is this more true today than in the Middle East. Desert Storm coalition troops are facing a foe with experience in using such weapons. Although the Patriot defensive missile has been effective in destroying a high percentage of the Scud-B missiles that Iraq has launched toward coalition forces or civilian populations, every launch brings concern that there may be a chemical warhead. There also has been some concern about use of the missiles for germ warfare. A research program at Fort Detrick, Md, about 70 km from Washington, DC, seeks to protect US military personnel against biological weapons in particular. It is essentially a defensive operation—that is, no offensive biological or chemical weapons have been developed there since 1970—with previously developed offensive weapons having been destroyed, says Ronald G. Williams, MD, the colonel who is
Acute Alcoholic Intoxication: A Critical Review
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pregnancy and Drug Addiction – Long-Term Consequences
Authors: Alasdair C Fraser, Sharon Cavanagh
Journal: Journal of the Royal Society of Medicine (1991)

With the prevalence of drug addiction amongst young women rising in the United Kingdom the problems associated with pregnancy in this group are increasingly being reported. An attempt has been made to determine whether the birth of a baby is a sufficient stimulus for the mother to cease her drug of addiction. Between the years 1966 and 1988, 86 such mothers gave birth at St Mary's Hospital, London, whom we were able to trace for at least one year after their last delivery. The results show that the majority of mothers continued with their drug use and where this is so the chances of the child remaining with her are markedly reduced. Discussion centres around possible ways of identifying those likely to succeed in drug withdrawal during pregnancy and the need for increasing and continued support for these mothers and their babies after they have left hospital.
Dynamic Landscapes of tRNA Transcriptomes and Translatomes in Diverse Mouse Tissues
Authors: Peng Yu, Siting Zhou, Yan Gao, Yu Liang, Wenbing Guo, Dan Ohtan Wang, Shuaiwen Ding, Shuibin Lin, Jinkai Wang, Yixian Cun
Journal: Genomics Proteomics & Bioinformatics (2022)

Abstract Although the function of tRNAs in the translational process is well established, it remains controversial whether tRNA abundance is tightly associated with translational efficiency (TE) in mammals. Moreover, how critically the expression of tRNAs contributes to the establishment of tissue-specific proteomes in mammals has not been well addressed. Here, we measured both tRNA expression using demethylase-tRNA sequencing (DM-tRNA-seq) and TE of mRNAs using ribosome-tagging sequencing (RiboTag-seq) in the brain, heart, and testis of mice. Remarkable variation in the expression of tRNA isodecoders was observed among different tissues. When the statistical effect of isodecoder-grouping on reducing variations is considered through permutating the anticodons, we observed an expected reduction in the variation of anticodon expression across all samples, an unexpected smaller variation of anticodon usage bias, and an unexpected larger variation of tRNA isotype expression at amino acid level. Regardless of whether or not they share the same anticodons, the isodecoders encoding the same amino acids are co-expressed across different tissues. Based on the expression of tRNAs and the TE of mRNAs, we find that the tRNA adaptation index (tAI) and TE are significantly correlated in the same tissues but not between tissues; and tRNA expression and the amino acid composition of translating peptides are positively correlated in the same tissues but not between tissues. We therefore hypothesize that the tissue-specific expression of tRNAs might be due to post-transcriptional mechanisms. This study provides a resource for tRNA and translation studies, as well as novel insights into the dynamics of tRNAs and their roles in translational regulation.