tbuckley/cabot-search huggingface dataset:
The Occurrence of Arsenic in the Body
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Management of perimenopausal and menopausal symptoms
Authors: Erin R Duralde, Talia H Sobel, JoAnn E Manson
Journal: BMJ (2023)

ABSTRACT Most women worldwide experience menopausal symptoms during the menopause transition or postmenopause. Vasomotor symptoms are most pronounced during the first four to seven years but can persist for more than a decade, and genitourinary symptoms tend to be progressive. Although the hallmark symptoms are hot flashes, night sweats, disrupted sleep, and genitourinary discomfort, other common symptoms and conditions are mood fluctuations, cognitive changes, low sexual desire, bone loss, increase in abdominal fat, and adverse changes in metabolic health. These symptoms and signs can occur in any combination or sequence, and the link to menopause may even be elusive. Estrogen based hormonal therapies are the most effective treatments for many of the symptoms and, in the absence of contraindications to treatment, have a generally favorable benefit:risk ratio for women below age 60 and within 10 years of the onset of menopause. Non-hormonal treatment options are also available. Although a symptom driven treatment approach with individualized decision making can improve health and quality of life for midlife women, menopausal symptoms remain substantially undertreated by healthcare providers.
Carbon‐Encapsulated Magnetite Nanodoughnut as a NIR‐II Responsive Nanozyme for Synergistic Chemodynamic–Photothermal Therapy
Authors: Xiangfu Meng, Zonghui Zhang, Yong Qian, Xingyu Wang, Yefeng Lin, Xinyi Shi, Wenchu Lin, Miqin Zhang, Hui Wang
Journal: Advanced Healthcare Materials (2023)

Magnetite-based nanozymes have attracted great interest for catalytic cancer therapy enabled by catalyzing hydrogen peroxide (H2 O2 ) to produce highly toxic hydroxyl radicals (•OH) to kill tumor cells. However, their therapeutic efficacies remain low due to insufficient •OH. Here, a light-responsive carbon-encapsulated magnetite nanodoughnuts (CEMNDs) with dual-catalytic activities for photothermal-enhanced chemodynamic therapy (CDT) is reported. The CEMNDs can accumulate in tumor and get into tumor cells and effectively act as peroxidase to convert H2 O2 to •OH that causes tumor cell death. The CEMNDs also possess intrinsic glutathione oxidase-like activity that which catalyzes the oxidation of reduced glutathione and produce lipid peroxidase for enhanced catalytic therapy. Furthermore, the CEMNDs can absorb 1064 nm light to elevate local temperature and increase release of Fe ions for photothermal therapy and enhanced CDT respectively. The in vivo experiments in an aggressive and drug-resistant metastatic mouse model of triple negative breast cancer model demonstrate excellent synergistic anti-tumor function and no measurable systemic toxicity of CEMNDs.
Anthropophagia
Authors: Benjamin Crawford
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Implications of Nonhuman “Authors”
Authors: Kentaro Matsui, Masahide Koda, Kazunari Yoshida
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Functional tumor cell-intrinsic STING, not host STING, drives local and systemic antitumor immunity and therapy efficacy following cryoablation
Authors: Mohammad Alshebremi, Suzanne L Tomchuck, Jay T Myers, Daniel T Kingsley, Saada Eid, Muta Abiff, Melissa Bonner, Shahrazad T Saab, Sung Hee Choi, Alex Yee-Chen Huang
Journal: Journal for ImmunoTherapy of Cancer (2023)

Despite its potential utility in delivering direct tumor killing and in situ whole-cell tumor vaccination, tumor cryoablation produces highly variable and unpredictable clinical response, limiting its clinical utility. The mechanism(s) driving cryoablation-induced local antitumor immunity and the associated abscopal effect is not well understood. The aim of this study was to identify and explore a mechanism of action by which cryoablation enhances the therapeutic efficacy in metastatic tumor models. We used the subcutaneous mouse model of the rhabdomyosarcoma (RMS) cell lines RMS 76-9STINGwt or RMS 76-9STING-/-, along with other murine tumor models, in C57BL/6 or STING-/- (TMEM173-/- ) mice to evaluate local tumor changes, lung metastasis, abscopal effect on distant tumors, and immune cell dynamics in the tumor microenvironment (TME). The results show that cryoablation efficacy is dependent on both adaptive immunity and the STING signaling pathway. Contrary to current literature dictating an essential role of host-derived STING activation as a driver of antitumor immunity in vivo, we show that local tumor control, lung metastasis, and the abscopal effect on distant tumor are all critically dependent on a functioning tumor cell-intrinsic STING signaling pathway, which induces inflammatory chemokine and cytokine responses in the cryoablated TME. This reliance extends beyond cryoablation to include intratumoral STING agonist therapy. Additionally, surveys of gene expression databases and tissue microarrays of clinical tumor samples revealed a wide spectrum of expressions among STING-related signaling components. Tumor cell-intrinsic STING pathway is a critical component underlying the effectiveness of cryoablation and suggests that expression of STING-related signaling components may serve as a potential therapy response biomarker. Our data also highlight an urgent need to further characterize tumor cell-intrinsic STING pathways and the associated downstream inflammatory response evoked by cryoablation and other STING-dependent therapy approaches.
Error in Methods
Journal: JAMA Network Open (2023)

Robyn Mitchell, MHSc; Joelle Cayen, BSc; Nisha Thampi, MD, MSc; Charles Frenette, MD; Jessica Bartoszko, HBSc; Kelly Baekyung Choi, MSc; Jeannette L. Comeau, MD, MSc; John Conly, MD; Chelsey Ellis, MD; Jennifer Ellison, MSc; John Embil, MD; Gerald Evans, MD; Lynn Johnston, MD, MSc; Jennie Johnstone, MD, PhD; Kevin C. Katz, MD, MSc; Pamela Kibsey, MD; Bonita Lee, MD, MSc (Epi); Marie-Astrid Lefebvre, MD, MSc; Yves Longtin, MD; Allison McGeer, MD, MSc; Dominik Mertz, MD, MSc; Jessica Minion, MD, MSc; Wallis Rudnick, PhD; Anada Silva, MPH; Stephanie W. Smith, MD, MSc; Jocelyn A. Srigley, MD, MSc; Kathryn N. Suh, MD, MSc; Jen Tomlinson, RN, BN, MHS; Alice Wong, MD, MPH; Linda Pelude, MSc
Management of Acetaminophen Poisoning in the US and Canada
Authors: Richard C. Dart, Michael E. Mullins, Theresa Matoushek, Anne-Michelle Ruha, Michele M. Burns, Karen Simone, Michael C. Beuhler, Kennon J. Heard, Maryann Mazer-Amirshahi, Christine M. Stork, Shawn M. Varney, Alexandra R. Funk, Lee F. Cantrell, Jon B. Cole, William Banner, Andrew I. Stolbach, Robert G. Hendrickson, Scott N. Lucyk, Marco L. A. Sivilotti, Mark K. Su, Lewis S. Nelson, Barry H. Rumack
Journal: JAMA Network Open (2023)

The US and Canada currently have no formal published nationwide guidelines for specialists in poison information or emergency departments for the management of acetaminophen poisoning, resulting in significant variability in management.To develop consensus guidelines for the management of acetaminophen poisoning in the US and Canada.Four clinical toxicology societies (America's Poison Centers, American Academy of Clinical Toxicology, American College of Medical Toxicology, and Canadian Association of Poison Control Centers) selected participants (n = 21). Led by a nonvoting chairperson using a modified Delphi method, the panel created a decision framework and determined the appropriate clinical management of a patient with acetaminophen poisoning. Unique to this effort was the collection of guidelines from most poison centers in addition to systematic collection and review of the medical literature. Comments from review by external organizations were incorporated before the guideline was finalized. The project began in March 2021 and ended in March 2023.The search retrieved 84 guidelines and 278 publications. The panel developed guidelines for emergency department management of single or repeated ingestion of acetaminophen. In addition, the panel addressed extended-release formulation, high-risk ingestion, coingestion of anticholinergics or opioids, age younger than 6 years, pregnancy, weight greater than 100 kg, and intravenous acetaminophen use. Differences from current US practice include defining acute ingestion as an ingestion presentation from 4 to 24 hours after overdose was initiated. A revised form of the Rumack-Matthew nomogram was developed. The term massive ingestion was replaced with the term high-risk ingestion and denoted by a specific nomogram line. Other recommendations include specific criteria for emergency department triage, laboratory evaluation and monitoring parameters, defining the role of gastrointestinal decontamination, detailed management of acetylcysteine treatment, associated adverse effects, and stopping criteria for acetylcysteine treatment, as well as criteria for consultation with a clinical toxicologist. Finally, specific treatment considerations, including acetylcysteine dosing, fomepizole administration, and considerations for extracorporeal elimination and transplant evaluation, were addressed.This qualitative study provides a consensus statement on consistent evidence-based recommendations for medical, pharmacy, and nursing education and practice to optimize care of patients with acetaminophen poisoning.
Novel tripeptide RKH derived from<i>Akkermansia muciniphila</i>protects against lethal sepsis
Authors: Shihao Xie, Jiaxin Li, Fengyuan Lyu, Qingming Xiong, Peng Gu, Yuqi Chen, Meiling Chen, Jingna Bao, Xianglong Zhang, Rongjuan Wei, Youpeng Deng, Hongzheng Wang, Zhenhua Zeng, Zhongqing Chen, Yongqiang Deng, Zhuoshi Lian, Jie Zhao, Wei Gong, Ye Chen, Ke-Xuan Liu, Yi Duan, Yong Jiang, Hong-Wei Zhou, Peng Chen
Journal: Gut (2023)

Objective The pathogenesis of sepsis is complex, and the sepsis-induced systemic proinflammatory phase is one of the key drivers of organ failure and consequent mortality. Akkermansia muciniphila (AKK) is recognised as a functional probiotic strain that exerts beneficial effects on the progression of many diseases; however, whether AKK participates in sepsis pathogenesis is still unclear. Here, we evaluated the potential contribution of AKK to lethal sepsis development. Design Relative abundance of gut microbial AKK in septic patients was evaluated. Cecal ligation and puncture (CLP) surgery and lipopolysaccharide (LPS) injection were employed to establish sepsis in mice. Non-targeted and targeted metabolomics analysis were used for metabolites analysis. Results We first found that the relative abundance of gut microbial AKK in septic patients was significantly reduced compared with that in non-septic controls. Live AKK supplementation, as well as supplementation with its culture supernatant, remarkably reduced sepsis-induced mortality in sepsis models. Metabolomics analysis and germ-free mouse validation experiments revealed that live AKK was able to generate a novel tripeptide Arg-Lys-His (RKH). RKH exerted protective effects against sepsis-induced death and organ damage. Furthermore, RKH markedly reduced sepsis-induced inflammatory cell activation and proinflammatory factor overproduction. A mechanistic study revealed that RKH could directly bind to Toll-like receptor 4 (TLR4) and block TLR4 signal transduction in immune cells. Finally, we validated the preventive effects of RKH against sepsis-induced systemic inflammation and organ damage in a piglet model. Conclusion We revealed that a novel tripeptide, RKH, derived from live AKK, may act as a novel endogenous antagonist for TLR4. RKH may serve as a novel potential therapeutic approach to combat lethal sepsis after successfully translating its efficacy into clinical practice.
Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma
Authors: Vincenzo Graziano, Andreas Dannhorn, Heather Hulme, Kate Williamson, Hannah Buckley, Saadia A Karim, Matthew Wilson, Sheng Y Lee, Brajesh P Kaistha, Sabita Islam, James E D Thaventhiran, Frances M Richards, Richard Goodwin, Rebecca Brais, Jennifer P Morton, Simon J Dovedi, Alwin G Schuller, Jim Eyles, Duncan I Jodrell
Journal: Journal for ImmunoTherapy of Cancer (2023)

The prognosis for patients with pancreatic ductal adenocarcinoma (PDAC) remains extremely poor. It has been suggested that the adenosine pathway contributes to the ability of PDAC to evade the immune system and hence, its resistance to immuno-oncology therapies (IOT), by generating extracellular adenosine (eAdo).
ZNF671 methylation test in cervical scrapings for cervical intraepithelial neoplasia grade 3 and cervical cancer detection
Authors: Peng Zhu, Jing Xiong, Ding Yuan, Xiang Li, Lili Luo, Ju Huang, Binbin Wang, Quanfang Nie, Shuli Wang, Liying Dang, Yan Chen, Shu Li, Yuhang An, Li Yang, Rong Liu, Yanping He, Xiong Li, Puxiang Chen, Honghao Zhou, Qing Li
Journal: Cell Reports Medicine (2023)

Effective triage of high-risk human papillomavirus (hrHPV)+ women is warranted to avoid unnecessary referral and overtreatment. Molecular triage tests have recently begun to impact cervical intraepithelial neoplasia grade 3 (CIN3) or cervical cancer (CC), termed CIN3+, detection. We find that zinc finger protein 671 methylation (ZNF671m) test has superior performance for CIN3+ detection in all single molecular triage tests, including HPV16/18 genotyping, paired box gene 1 methylation (PAX1m), and ZNF671m, in the training set. Using ZNF671m test instead of Thinprep cytologic test (TCT) as a single triage strategy or as a combined triage strategy with HPV16/18 genotyping has achieved comparable sensitivity but higher specificity for CIN3+ detection among 391 hrHPV+ women in the validation set. Little attention has been paid to the women with hrHPV− status but detected CIN3+. We find that the CIN3+ risk after a negative result could be reduced further by triage using ZNF671m in hrHPV− patients.
Non-invasive tumor microenvironment evaluation and treatment response prediction in gastric cancer using deep learning radiomics
Authors: Yuming Jiang, Kangneng Zhou, Zepang Sun, Hongyu Wang, Jingjing Xie, Taojun Zhang, Shengtian Sang, Md Tauhidul Islam, Jen-Yeu Wang, Chuanli Chen, Qingyu Yuan, Sujuan Xi, Tuanjie Li, Yikai Xu, Wenjun Xiong, Wei Wang, Guoxin Li, Ruijiang Li
Journal: Cell Reports Medicine (2023)

The tumor microenvironment (TME) plays a critical role in disease progression and is a key determinant of therapeutic response in cancer patients. Here, we propose a noninvasive approach to predict the TME status from radiological images by combining radiomics and deep learning analyses. Using multi-institution cohorts of 2,686 patients with gastric cancer, we show that the radiological model accurately predicted the TME status and is an independent prognostic factor beyond clinicopathologic variables. The model further predicts the benefit from adjuvant chemotherapy for patients with localized disease. In patients treated with checkpoint blockade immunotherapy, the model predicts clinical response and further improves predictive accuracy when combined with existing biomarkers. Our approach enables noninvasive assessment of the TME, which opens the door for longitudinal monitoring and tracking response to cancer therapy. Given the routine use of radiologic imaging in oncology, our approach can be extended to many other solid tumor types.
Implications of Nonhuman “Authors”
Authors: Chika Edward Uzoigwe
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P1644: ADP-DEPENDENT PLATELET ACTIVATION IS IMPORTANT IN THE DEVELOPMENT OF VENOUS THROMBOSIS DURING A LONG-DISTANCE FLIGHT
Authors: Julie Tourn, Estelle Carminita, Lydie Crescence, Laurie Bruzzese, Nabil Adjriou, Regis Guieu, Christophe Dubois, Laurence Panicot-Dubois
Journal: HemaSphere (2023)

Topic: 34. Thrombosis and vascular biology - Biology & Translational Research Background: The incidence of high altitude in venous thrombosis embolism (VTE) has been intensively documented. Prolonged exposure to hypobaric hypoxia triggers several mechanisms including coagulation disorders. Clinical studies show a correlation between long-distance flight and the development of deep vein thrombosis (DVT). Aircraft manufacturers create pressurized environments for the cabin with atmospheric gas partial pressures equivalent to altitudes of 1981 m to 2440 m. Aims: We investigated the effect of a long-distance flight in VTE. Methods: To understand this, we performed 24 hours of DVT in mice exposed to 6 hours of hypobaric hypoxia (“flight”) or normobaric normoxia (control) conditions. These “flight” conditions simulate a 6 hours airline cabin environment. Results: We observed that thrombi were significantly bigger and heavier in mice exposed to flight conditions than the control group. The composition of the thrombi in the two groups was also different. Thrombi from the flight group of mice contained significantly more neutrophils and fibrin fibers than the control ones. Consistently, a significant decrease in the concentration of circulating leukocytes -and neutrophils - was observed in mice exposed to hypobaric hypoxia conditions. Interestingly, no difference was observed in the quantity of NETs, CitH3 positive, NE-positive and Fibrin positive neutrophils in the thrombi in the two groups of mice, indicating that neutrophils/NETs may not be involved in the development of venous thrombosis during a flight. ADP has been previously described as a key mediator produced during hypobaric and hypoxia. We then compared the development of venous thrombosis in wild-type and P2RY12 deficient mice. Although no difference was observed in the “control” conditions between the two group of mice, the development of thrombi obtained in the P2RY12-/- mice were not affected by the changes in the atmospheric gas partial pressures to mimic the flight conditions. Summary/Conclusion: Taken together, these data indicate that ADP-dependent activation of platelets is playing an important role in the development of DVT under hypobaric hypoxia conditions. Targeting activation of platelets rather than the coagulation factors may thus constitute a new strategy to prevent DVT during long flight. Keywords: Deep venous thrombosis, Platelet activation, Thrombosis, Hypercoagulation