tbuckley/cabot-search huggingface dataset:
Multidimensional Immune Profiling of Cutaneous Lupus Erythematosus In Vivo Stratified by Patient Response to Antimalarials
Authors: Jay Patel, Thomas Vazquez, Felix Chin, Emily Keyes, Daisy Yan, DeAnna Diaz, Madison Grinnell, Meena Sharma, Yubin Li, Rui Feng, Grant Sprow, Josh Dan, Victoria P. Werth
Journal: Arthritis & Rheumatology (2022)

Objective The pathogenesis of cutaneous lupus erythematosus (CLE) is multifactorial, and CLE is difficult to treat due to the heterogeneity of inflammatory processes among patients. Antimalarials such as hydroxychloroquine (HCQ) and quinacrine (QC) have long been used as first‐line systemic therapy; however, many patients do not respond to treatment with antimalarials and require systemic immunosuppressants that produce undesirable side effects. Given the complexity and the unpredictability of responses to antimalarial treatments in CLE patients, we sought to characterize the immunologic profile of patients with CLE stratified by subsequent treatment outcomes to identify potential biomarkers of inducible response. Methods We performed mass cytometry imaging of multiple immune cell types and inflammation markers in treatment‐naive skin biopsy samples from 48 patients with CLE to identify baseline immunophenotypes that may predict the response to antimalarial therapy. Patients were stratified according to their response to treatment with antimalarials, as HCQ responders, QC responders, or nonresponders. Results HCQ responders demonstrated increased CD4+ T cells compared to the QC responder group. Patients in the nonresponder group were found to have decreased Treg cells compared to QC responders and increased central memory T cells compared to HCQ responders. QC responders expressed increased phosphorylated stimulator of interferon genes (pSTING) and interferon‐κ (IFNκ) compared to HCQ responders. Phosphorylated STING and IFNκ were found to be localized to conventional dendritic cells (cDCs), and the intensity of pSTING and IFNκ staining was positively correlated with the number of cDCs on a tissue and cellular level. Neighborhood analysis revealed decreased regulatory cell interactions in nonresponder patients. Hierarchical clustering revealed that nonresponder patients could be further differentiated based on expression of pSTAT2, pSTAT3, pSTAT4, pSTAT5, phosphorylated interferon regulatory factor 3 (pIRF3), granzyme B, pJAK2, interleukin‐4 (IL‐4), IL‐17, and IFNγ. Conclusion These findings indicate differential immune cell compositions between patients with CLE, offering guidance for future research on precision‐based medicine and treatment response.
Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: A promising drug Potentilla discolor Bunge
Authors: Longshan Ji, Qian Li, Yong He, Xin Zhang, Zhenhua Zhou, Yating Gao, Miao Fang, Zhuo Yu, Robim M. Rodrigues, Yueqiu Gao, Man Li
Journal: Acta Pharmaceutica Sinica B (2022)

Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive accumulation of hepatic lipids and metabolic stress-induced liver injury. There are currently no approved effective pharmacological treatments for NAFLD. Traditional Chinese medicine (TCM) has been used for centuries to treat patients with chronic liver diseases without clear disease types and mechanisms. More recently, TCM has been shown to have unique advantages in the treatment of NAFLD. We performed a systematic review of the medical literature published over the last two decades and found that many TCM formulas have been reported to be beneficial for the treatment of metabolic dysfunctions, including Potentilla discolor Bunge (PDB). PDB has a variety of active compounds, including flavonoids, terpenoids, organic acids, steroids and tannins. Many compounds have been shown to exhibit a series of beneficial effects for the treatment of NAFLD, including anti-oxidative and anti-inflammatory functions, improvement of lipid metabolism and reversal of insulin resistance. In this review, we summarize potential therapeutic effects of TCM formulas for the treatment of NAFLD, focusing on the medicinal properties of natural active compounds from PDB and their underlying mechanisms. We point out that PDB can be classified as a novel candidate for the treatment and prevention of NAFLD.
Skeletal and extraskeletal disorders of biomineralization
Authors: Michael T. Collins, Gemma Marcucci, Hans-Joachim Anders, Giovanni Beltrami, Jane A. Cauley, Peter R. Ebeling, Rajiv Kumar, Agnès Linglart, Luca Sangiorgi, Dwight A. Towler, Ria Weston, Michael. P. Whyte, Maria Luisa Brandi, Bart Clarke, Rajesh V. Thakker
Journal: Nature Reviews Endocrinology (2022)
Hostile Takeover: Tregs Expand in IFNγ-Rich AML Microenvironment
Authors: P. Brent Ferrell, Shahram Kordasti
Journal: Clinical Cancer Research (2022)

Summary The unexpected higher level of IFNγ in a subset of patients with acute myeloid leukemia (AML; IFNγhigh) upregulates immunosuppressive genes in mesenchymal stem cells (MSC) and expands regulatory T cells through IDO1 overexpression. IDO1 and IFNG gene expression was positively correlated and required both leukemia cells and MSCs, as IFNγhigh cells were not able to induce Tregs alone. See related article by Corradi et al., p. 3141
Targeting DNA damage response in cardiovascular diseases: from pathophysiology to therapeutic implications
Authors: Lin Wu, James R Sowers, Yingmei Zhang, Jun Ren
Journal: Cardiovascular Research (2022)

Cardiovascular diseases (CVDs) arise from a complex interplay among genomic, proteomic, and metabolomic abnormalities. Emerging evidence has recently consolidated the presence of robust DNA damage in a variety of cardiovascular disorders. DNA damage triggers a series of cellular responses termed DNA damage response (DDR) including detection of DNA lesions, cell cycle arrest, DNA repair, cellular senescence, and apoptosis, in all organ systems including hearts and vasculature. Although transient DDR in response to temporary DNA damage can be beneficial for cardiovascular function, persistent activation of DDR promotes the onset and development of CVDs. Moreover, therapeutic interventions that target DNA damage and DDR have the potential to attenuate cardiovascular dysfunction and improve disease outcome. In this review, we will discuss molecular mechanisms of DNA damage and repair in the onset and development of CVDs, and explore how DDR in specific cardiac cell types contributes to CVDs. Moreover, we will highlight the latest advances regarding the potential therapeutic strategies targeting DNA damage signalling in CVDs.
Blistering Lesions Associated With Loncastuximab Tesirine
Authors: Shadai Gociman, Kelsey Baron, Boyu Hu, Jamie Zussman, Lauren M. Madigan
Journal: JAMA Dermatology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Social bias insights concern judgments rather than real-world decisions
Authors: Michał Białek, Igor Grossmann
Journal: Behavioral and Brain Sciences (2022)

Abstract Judgments differ from decisions. Judgments are more abstract, decontextualized, and bear fewer consequences for the agent. In pursuit of experimental control, psychological experiments on bias create a simplified, bare-bone representation of social behavior. These experiments resemble conditions in which people judge others, but not how they make real-world decisions.
Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells
Authors: Martin Schepelmann, Marianna Ranieri, Irene Lopez-Fernandez, Thomas S. Webberley, Sarah C. Brennan, Polina L. Yarova, Joao Graca, Umar-Khetaab Hanif, Christian Müller, Teresa Manhardt, Martina Salzmann, Helen Quasnichka, Sally A. Price, Donald T. Ward, Thierry Gilbert, Vladimir V. Matchkov, Robert A. Fenton, Amanda Herberger, Jenna Hwong, Christian Santa Maria, Chia-Ling Tu, Enikö Kallay, Giovanna Valenti, Wenhan Chang, Daniela Riccardi
Journal: Journal of the American Society of Nephrology (2022)

Impaired mineral ion metabolism is a hallmark of CKD-metabolic bone disorder. It can lead to pathologic vascular calcification and is associated with an increased risk of cardiovascular mortality. Loss of calcium-sensing receptor (CaSR) expression in vascular smooth muscle cells exacerbates vascular calcification in vitro. Conversely, vascular calcification can be reduced by calcimimetics, which function as allosteric activators of CaSR.To determine the role of the CaSR in vascular calcification, we characterized mice with targeted Casr gene knockout in vascular smooth muscle cells ( SM22α CaSR Δflox/Δflox ).Vascular smooth muscle cells cultured from the knockout (KO) mice calcified more readily than those from control (wild-type) mice in vitro. However, mice did not show ectopic calcifications in vivo but they did display a profound mineral ion imbalance. Specifically, KO mice exhibited hypercalcemia, hypercalciuria, hyperphosphaturia, and osteopenia, with elevated circulating fibroblast growth factor 23 (FGF23), calcitriol (1,25-D3), and parathyroid hormone levels. Renal tubular α-Klotho protein expression was increased in KO mice but vascular α-Klotho protein expression was not. Altered CaSR expression in the kidney or the parathyroid glands could not account for the observed phenotype of the KO mice.These results suggest that, in addition to CaSR's established role in the parathyroid-kidney-bone axis, expression of CaSR in vascular smooth muscle cells directly contributes to total body mineral ion homeostasis.
In Vivo Coronary 18F-Sodium Fluoride Activity
Authors: Wanwan Wen, Mingxin Gao, Mingkai Yun, Jingjing Meng, Wenyuan Yu, Ziwei Zhu, Yi Tian, Tiantian Mou, Yandong Zhang, Marcus Hacker, Sijin Li, Yang Yu, Xiang Li, Xiaoli Zhang
Journal: JACC. Cardiovascular imaging (2022)
Relationship between the Bolsa Família national cash transfer programme and suicide incidence in Brazil: A quasi-experimental study
Authors: Daiane Borges Machado, Elizabeth Williamson, Julia M. Pescarini, Flavia J. O. Alves, Luís F. S. Castro-de-Araujo, Maria Yury Ichihara, Laura C. Rodrigues, Ricardo Araya, Vikram Patel, Maurício L. Barreto
Journal: PLoS Medicine (2022)

Socioeconomic factors have been consistently associated with suicide, and economic recessions are linked to rising suicide rates. However, evidence on the impact of socioeconomic interventions to reduce suicide rates is limited. This study investigates the association of the world's largest conditional cash transfer programme with suicide rates in a cohort of half of the Brazilian population.
Dupilumab-associated head and neck dermatitis resolves temporarily with itraconazole therapy and rapidly with transition to upadacitinib, with Malassezia-specific immunoglobulin E levels mirroring clinical response
Authors: Emily Kozera, Akshay Flora, Thomas Stewart, Kyra Gill, Jennifer Xu, Mae Anne De La Vega, John W. Frew
Journal: Journal of the American Academy of Dermatology (2022)
Commentary
Authors: Heidi R. Wassef, Patrick M. Colletti
Journal: Clinical Nuclear Medicine (2022)

Abstract Høilund-Carlsen and colleagues raise important issues related to amyloid PET, diagnosis of Alzheimer disease, and recently approved antiamyloid treatment aducanumab. We discuss new developments that may direct us to methods of presymptomatic detection of Alzheimer disease and development of effective prevention and therapy.
Cover Image, Volume 42, Issue 5
Authors: Ziyue Zhou, Huazhen Liu, Yiying Yang, Jingya Zhou, Lidan Zhao, Hua Chen, Yunyun Fei, Wen Zhang, Mengtao Li, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang, Huaxia Yang, Xuan Zhang
Journal: Cancer Communications (2022)

The cover image is based on the Research Article The five major autoimmune diseases increase the risk of cancer: epidemiological data from a large-scale cohort study in China by Huaxia Yang et al., https://doi.org/10.1002/cac2.12283.
Emerging Viral Infections and the Potential Impact on Hypertension, Cardiovascular Disease, and Kidney Disease
Authors: Solomiia Savedchuk, Rasha Raslan, Sarah Nystrom, Matthew A. Sparks
Journal: Circulation Research (2022)

Viruses are ubiquitous in the environment and continue to have a profound impact on human health and disease. The COVID-19 pandemic has highlighted this with impressive morbidity and mortality affecting the world’s population. Importantly, the link between viruses and hypertension, cardiovascular disease, and kidney disease has resulted in a renewed focus and attention on this potential relationship. The virus responsible for COVID-19, SARS-CoV-2, has a direct link to one of the major enzymatic regulatory systems connected to blood pressure control and hypertension pathogenesis, the renin-angiotensin system. This is because the entry point for SARS-CoV-2 is the ACE2 (angiotensin-converting enzyme 2) protein. ACE2 is one of the main enzymes responsible for dampening the primary effector peptide Ang II (angiotensin II), metabolizing it to Ang-(1-7). A myriad of clinical questions has since emerged and are covered in this review. Several other viruses have been linked to hypertension, cardiovascular disease, and kidney health. Importantly, patients with high-risk apolipoprotein L1 ( APOL1 ) alleles are at risk for developing the kidney lesion of collapsing glomerulopathy after viral infection. This review will highlight several emerging viruses and their potential unique tropisms for the kidney and cardiovascular system. We focus on SARS-CoV-2 as this body of literature in regards to cardiovascular disease has advanced significantly since the COVID-19 pandemic.
Emergency Department Care Transition Programs—Value-Based Care Interventions That Need System-Level Support
Authors: Kevin Biese, Timothy A. Lash, Maura Kennedy
Journal: JAMA Network Open (2022)

Fruhan and Bills 1 report that their quality improvement callback program for patients presenting to the emergency department (ED) was associated with a decrease in 3-day and 7-day ED revisits compared with control patients who did not receive this intervention.Patients enrolled in the
Drug-Tolerant Persister Cells in Cancer Therapy Resistance
Authors: Pavan Kumar Dhanyamraju, Todd D. Schell, Shantu Amin, Gavin P. Robertson
Journal: Cancer Research (2022)

One of the current stumbling blocks in our fight against cancer is the development of acquired resistance to therapy, which is attributable to approximately 90% of cancer-related deaths. Undercutting this process during treatment could significantly improve cancer management. In many cases, drug resistance is mediated by a drug-tolerant persister (DTP) cell subpopulation present in tumors, often referred to as persister cells. This review provides a summary of currently known persister cell subpopulations and approaches to target them. A specific DTP cell subpopulation with elevated levels of aldehyde dehydrogenase (ALDH) activity has stem cell-like characteristics and a high level of plasticity, enabling them to switch rapidly between high and low ALDH activity. Further studies are required to fully elucidate the functions of ALDH-high DTP cells, how they withstand drug concentrations that kill other cells, and how they rapidly adapt under levels of high cellular stress and eventually lead to more aggressive, recurrent, and drug-resistant cancer. Furthermore, this review addresses the processes used by the ALDH-high persister cell subpopulation to enable cancer progression, the ALDH isoforms important in these processes, interactions of ALDH-high DTPs with the tumor microenvironment, and approaches to therapeutically modulate this subpopulation in order to more effectively manage cancer.
COVID-19 in Patients with Pulmonary Hypertension: A National Prospective Cohort Study
Authors: David Montani, Marie-Caroline Certain, Jason Weatherald, Xavier Jaïs, Sophie Bulifon, Elise Noel-Savina, Ana Nieves, Sébastien Renard, Julie Traclet, Hélène Bouvaist, Marianne Riou, Pascal de Groote, Pamela Moceri, Laurent Bertoletti, Nicolas Favrolt, Anne Guillaumot, Etienne-Marie Jutant, Antoine Beurnier, Athénaïs Boucly, Nathan Ebstein, Mitja Jevnikar, Jérémie Pichon, Sophia Keddache, Mariana Preda, Anne Roche, Sabina Solinas, Andrei Seferian, Martine Reynaud-Gaubert, Vincent Cottin, Laurent Savale, Marc Humbert, Olivier Sitbon, Ahmad Kais, Artaud-Macari Elise, Chabanne Céline, Chaouat Ari, Dauphin surnameClaire, Gagnadoux Frédéric, Gaudoin Anne, Hascoet Sébastien, Horeau-Langlard Delphine, Inamo Jocelyn, Lamia Bouchra, Magro Pascal, Meurice Jean-Claude, Poubeau Patrice, Prevot Grégoire, Rosario Roger, None Servettaz
Journal: American Journal of Respiratory and Critical Care Medicine (2022)

Rationale: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with pulmonary endothelial dysfunction. There are limited data available on the outcomes of coronavirus disease (COVID-19) in patients with pulmonary hypertension (PH), a disease characterized by pulmonary endothelial dysfunction. Objectives: To describe characteristics and outcomes of patients with precapillary PH and COVID-19. Methods: We prospectively collected characteristics, management, and outcomes of adult patients with precapillary PH in the French PH network who had COVID-19 between February 1, 2020, and April 30, 2021. Clinical, functional, and hemodynamic characteristics of PH before COVID-19 were collected from the French PH registry. Measurements and Main Results: A total of 211 patients with PH (including 123 with pulmonary arterial hypertension, 47 with chronic thromboembolic PH, and 41 with other types of PH) experienced COVID-19, and 40.3% of them were outpatients, 32.2% were hospitalized in a conventional ward, and 27.5% were in an ICU. Among hospitalized patients (n = 126), 54.0% received corticosteroids, 37.3% high-flow oxygen, and 11.1% invasive ventilation. Right ventricular and acute renal failure occurred in 30.2% and 19.8% of patients, respectively. Fifty-two patients (all hospitalized) died from COVID-19. Overall mortality was 24.6% (95% CI [confidence interval], 18.8-30.5) and in-hospital mortality 41.3% (95% CI, 32.7-49.9). Nonsurvivors were significantly older, more frequently male and suffering comorbidities (diabetes, chronic respiratory diseases, systemic hypertension, chronic cardiac diseases, and/or chronic renal failure), and had more severe PH at their most recent evaluation preceding COVID-19 diagnosis (in terms of functional class and 6-minute-walk distance; all P < 0.05). Use of pulmonary arterial hypertension therapy was similar between survivors and nonsurvivors. Conclusions: COVID-19 in patients with precapillary PH was associated with a high in-hospital mortality. The typical risk factors for severe COVID-19 and severity of PH were associated with mortality in this population.
COVID-19 and Lessons to Improve Preparedness for the Next Pandemic—Reply
Authors: Jennifer B. Nuzzo, Lawrence O. Gostin
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mortality Among Patients With Early-Onset Atrial Fibrillation and Rare Variants in Cardiomyopathy and Arrhythmia Genes
Authors: Zachary T. Yoneda, Katherine C. Anderson, Fei Ye, Joseph A. Quintana, Matthew J. O’Neill, Richard A. Sims, Lili Sun, Andrew M. Glazer, Giovanni Davogustto, Majd El-Harasis, James L. Laws, Brittany N. Saldivar, Diane M. Crawford, Thomas Stricker, Quinn Wells, Dawood Darbar, Gregory F. Michaud, Lynne W. Stevenson, Steven A. Lubitz, Patrick T. Ellinor, Dan M. Roden, M. Benjamin Shoemaker
Journal: JAMA Cardiology (2022)

Patients with early-onset atrial fibrillation (AF) are enriched for rare variants in cardiomyopathy and arrhythmia genes. The clinical significance of these rare variants in patients with early-onset AF is unknown.
Corrigendum to “A randomised phase II study investigating durvalumab in addition to an anthracycline taxane-based neoadjuvant therapy in early triple-negative breast cancer: clinical results and biomarker analysis of GeparNuevo study”
Authors: S. Loibl, M. Untch, N. Burchardi, J. Huober, B.V. Sinn, J.-U. Blohmer, E.-M. Grischke, J. Furlanetto, H. Tesch, C. Hanusch, K. Engels, M. Rezai, C. Jackisch, W.D. Schmitt, G. von Minckwitz, J. Thomalla, S. Kümmel, B. Rautenberg, P.A. Fasching, K. Weber, K. Rhiem, C. Denkert, A. Schneeweiss
Journal: Annals of Oncology (2022)
Antiabortion Laws and Implications for Patients With Cardiovascular Disease in Pregnancy
Authors: Verity N. Ramirez, Melissa Ferraro-Borgida, Sarah Lindsay
Journal: JAMA Cardiology (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal