tbuckley/cabot-search huggingface dataset:
AB0668 ASYMMETRICAL DIMETHYLARGININE CORRELATES WITH WORSENING PERIPHERAL MICROANGIOPATHY IN SYSTEMIC SCLEROSIS
Authors: E. Pagkopoulou, S. Soulaidopoulos, E. Triantafyllidou, G. Kitas, A. Garyfallos, T. Dimitroulas
Journal: Annals of the Rheumatic Diseases (2022)

Background Systemic sclerosis (SSc) is a connective tissue disease characterized primarily by, micro-angiopathy and endothelial dysfunction stimulate fibrotic process. Asymmetrical dimethylarginine (ADMA) is an endogenous nitric oxide (NO) inhibitor and represents a novel risk factor for vascular dysfunction. Nailfold Video Capillaroscopy (NVC) is a non-invasive and reliable technique for the evaluation of microvasculopathy in SSc. Objectives The aim of this study was to examine the possible association between ADMA and microvascular involvement in patients with SSc. Methods This was a cross-sectional study including consecutive SSc patients attending the Scleroderma Outpatient Clinic. ADMA was measured in serum samples by using commercial enzyme immunoassay ELISA kit (Aviva Systems Biology ADMA ELISA Kit). Participants underwent NVC with qualitative and semi-quantitative assessment and all parameters were measured in the distal row of each finger. The findings were classified in one of the three qualitative NVC patterns: early, active, and late. Results Eighty-one (92,6% women) SSc individuals with mean age 55.44±13.4 years and disease duration 6.78 [9.22] years were included in this analysis. Within-groups comparisons revealed a trend between higher ADMA levels and progressive micro-vasculopathy (1,29 [2,1]vs 1,57 [1,95] vs 2,41 [3,87]; for early, active and late patterns respectively, p=0.039) (Figure 1). Furthermore, ADMA concentration was significantly associated with the number of capillaries/mm (r= -0.235; p=0.035). Figure 1. Serum ADMA levels in the early, active, and late NVC patterns Conclusion Serum ADMA levels were significantly associated with advancing stages of microcirculatory abnormalities suggesting that ADMA may have a role in promoting microvascular endothelial dysfunction in SSc individuals. References [1]Abnormal nitric oxide metabolism in systemic sclerosis: increased levels of nitrated proteins and asymmetric dimethylarginine (Black CM, et al, Rheumatology (Oxford). 2006 Jun;45(6):676-84.) [2]Evaluation of endothelial dysfunction and clinical events in patients with early-stage vasculopathy in limited systemic sclerosis (Jud P, et al, Clin Exp Rheumatol. 2021 Jul-Aug;39 Suppl 131(4):57-65.) [3]Endothelial dysfunction, microvascular damage and ischemic peripheral vasculopathy in systemic sclerosis (Silva I, et al, Clin Hemorheol Microcirc. 2017;66(2):117-130.) Disclosure of Interests None declared
POS0586 DIAGNOSIS OF MENTAL DISORDER COMPLICATED BY RHEUMATOID ARTHRITIS: A STUDY OF THE VALIDITY OF A PSYCHIATRIST’S DIAGNOSIS AND QUESTIONNAIRE METHOD
Authors: Y. Miwa, H. Tomioka, M. Hosaka, Y. Mitamura
Journal: Annals of the Rheumatic Diseases (2022)

Background It has been reported that about 15% of patients with rheumatoid arthritis (RA) have depression, and most of these studies have used questionnaire methods. Most of the studies have used questionnaires for depression. Because the depression questionnaire includes questions about physical symptoms, it is necessary to be careful in interpreting the results when there is an underlying disease. In addition, there are no studies on other mental disorders. Objectives In this study, we examined the validity of the questionnaire method for the diagnosis of RA complicated by psychiatric disorders. Methods Forty-nine outpatients with RA who agreed to participate in this study were included. Age, gender, type of Disease-modifying anti-rheumatic drugs, prednisolone use, presence of diabetes, hypertension, dyslipidemia, and CRP were investigated. The Patient Health Questionnaire-9 (PHQ-9) and Center for Epidemiologic Studies Depression Scale (CES-D) questionnaires were used; a score of 10 or more on the PHQ-9 and 16 or more on the CES-D was considered a cutoff. The psychiatrist was blinded to the results of the questionnaire and conducted a structured interview in a separate room. The psychiatrist’s diagnosis was defined as the Gold Standard, and was compared with the PHQ-9 and CES-D. Results Psychiatrist’s diagnosis was abnormal in 9 patients. This included one patient with major depression, one patient with moderate depression, two patients with minor depression, and two patients with adjustment disorder. The PHQ-9 had a specificity of 98%, a sensitivity of 33%, a positive predictive value of 75%, and a negative predictive value of 87%. The CES-D had a specificity of 82%, a sensitivity of 100%, a positive predictive value of 56%, and a negative predictive value of 100%. Conclusion The PHQ-9 and CES-D may be useful in screening for psychiatric disorders including associated with RA. Disclosure of Interests None declared.
POS1248 URIC ACID AND COVID-19: PATTERN OF CHANGES AND ASSOCIATION WITH PROGNOSIS
Authors: A. Sydorova, O. Iaremenko
Journal: Annals of the Rheumatic Diseases (2022)

Background Coronavirus disease causes a proximal tubule dysfunction of kidneys, inducing uric acid loss [1]. It has been established that several changes in laboratory markers (C-reactive protein (CRP), ferritin, interleukin-6 (IL-6)) can predict the severity of Covid-19 [2]. The purpose of this retrospective study was to analyze whether uric acid could act as another predictor of severe Covid-19. Objectives To evaluate the relationship between the severity of Covid-19 and uric acid levels on admission to the hospital. Methods This retrospective study included 150 hospitalized patients with confirmed Covid-19 (mean age 60.3±14.6 years; 52% were men), the severity of which was determined by the presence and type of oxygen support: (1) without O2, (2) O2 by mask or nasal cannula, (3) continuous positive airway pressure, (4) positive bi-pressure in the airways or high-flow oxygen, (5) invasive ventilation. Among them, 90 subjects required oxygen support, and 60 people didn’t. The mortality rate in our study was 9.3%. The average uric acid level was compared with patients without Covid-19 (40 subjects). The study included patients who didn’t receive urate-lowering therapy. Levels of CRP, ferritin, IL-6, D-dimer were also determined on admission. The Spearman’s rank coefficient was used for measuring correlation. Results The mean uric acid level in patients with coronavirus disease was 251.5±104.1 µmol/L; without Covid-19 it was significantly higher — 328.6±96.9 µmol/L (p&lt;0.001). Approximately one in four (24.6%) Covid-19 patients had uric acid levels below the lower limit of normal (208 µmol/L for men, 155 µmol/L for women). A decrease in serum uric acid levels was also observed in patients suffering from asymptomatic hyperuricemia or gout. However, there was no correlation between uric acid levels and disease severity (r=0.01, p=0.88). Also, uric acid levels did not correlate with other laboratory markers of severe Covid-19 (CRP: r=0.07, p=0.73; ferritin: r=0.15, p=0,07; IL-6: r=0.11, p=0,22; D-dimer: r=0.02, p=0,79). Conclusion Low uric acid levels are common in patients with Covid-19, but are not predictive of a more severe course of this disease. A correlation between uric acid and the level of other laboratory markers of severe Covid-19 was not found. References [1]Dufour, I., Werion, A., Belkhir, L. et al. (2021). Serum uric acid, disease severity and outcomes in COVID-19. Crit Care 25, 212 https://doi.org/10.1186/s13054-021-03616-3 [2]Huang, I., Pranata, R., Lim, M. A., et al. (2020). C-reactive protein, procalcitonin, D-dimer, and ferritin in severe coronavirus disease-2019: a meta-analysis. Therapeutic advances in respiratory disease, 14, 1753466620937175. https://doi.org/10.1177/1753466620937175 Disclosure of Interests None declared
Returning to Work After Mild Traumatic Brain Injury—Considering the Impact of Employer Support
Authors: Tara L. Sharma
Journal: JAMA Network Open (2022)

Étienne Gaudette, PhD; Seth A. Seabury, PhD; Nancy Temkin, PhD; Jason Barber, MS; Anthony M. DiGiorgio, DO, MHA; Amy J. Markowitz, JD; Geoffrey T. Manley, MD, PhD; TRACK-TBI Investigators; Neeraj Badjatia; Ann-Christine Duhaime; Adam Ferguson; Shankar Gopinath; Ramesh Grandhi; Ruchira Jha; C Dirk Keene; Ryan Kitagawa; Christine Mac Donald; Christopher Maddedn; Mike McCrea; Pratik Mukherjee; Laura Ngwenya; David Okonkwo; Claudia Robertson; Eric Rosenthal; Andrea Schneider; David Schnyer; Murray Stein; Sabrina Taylor; Mary Vassar; John Yue
AB0986 RISK OF SARCOPENIA IN THE WOMEN WITH OSTEOARTHRITIS
Authors: N. Grygorieva, N. Zaverukha, A. Musiienko, M. Bystrytska
Journal: Annals of the Rheumatic Diseases (2022)

Background Recently, physicians all over the world have been focusing on the relationship between sarcopenia and osteoarthritis (OA) [1, 2]. This connection is considered from different positions: as coexisting conditions, sarcopenia as a risk factor for the progression of OA, or OA as a risk factor for sarcopenia. Objectives The aim of this study was to determine the risk of sarcopenia (according to the SARC-F Questionnaire) and the level of probable sarcopenia in Ukrainian women with (hip and knee) OA. Methods The study included 271 women aged 50-84 years old (mean age 65.6 ±8.0 years, mean height 162.2±5.6, mean body weight 76.7±14.2, mean BMI 29.1±5.1). All subjects were divided into 2 groups: the group of healthy women (group I, n=176), a group of patients with hip or knee osteoarthritis (OA) (group II, n=95). The risk of sarcopenia was determined by the SARC-F Questionnaire. The probable sarcopenia was determined due to muscles strength (handgrip strength using spring hand dynamometer ≤ 16(kg)) and physical performance (5-time chair stand test &gt; 15 s), the fall risk – by Desmond Fall Risk Questionnaires and function – according to the assessment of IADL scale. Results In 20.3% of females without musculoskeletal pathology and in 34.7% of women with OA was detected high risk of sarcopenia. The probable sarcopenia was practically 2 times higher in patients with OA and was equal to 42.1% compared to 21.5% in healthy women. According to the Desmond Fall Risk Questionnaire, 27.5% of healthy subjects and 49.3% with OA had increased fall risk. Low function (according to the assessment of the IADL scale) was detected in 36.4% of females without pathology of the musculoskeletal system and in 57.2% of women with OA. Conclusion Our results demonstrated that the incidence of probable sarcopenia was 2 times higher in women with hip and knee OA, as well as the risk of sarcopenia – 34.7%, compared to healthy subjects – 20.3%. Also, the risk of falls and the need for outside help were higher in patients with hip and knee OA but their function (by IADL scale) was significantly lower. References [1]Amirthalingam H., Cicuttini F. M., Wang Y. et al. (2019). Association between sarcopenia and osteoarthritis-related knee structural changes: a systematic review. Osteoarthritis and Cartilage, 27, S472. doi:10.1016/j.joca.2019.02.515. [2]Jin W. S., Choi E. J., Lee S. Y. et al. (2017). Relationships among Obesity, Sarcopenia, and Osteoarthritis in the Elderly. Journal of Obesity &amp; Metabolic Syndrome, 26(1), 36–44. doi:10.7570/jomes.2017.26.1.36. Disclosure of Interests None declared
AB1077 INFECTIOUS SPONDYLODISCITIS IN ELDERLY: IS IT MORE SEVERE DISEASE?
Authors: S. Rekik, Z. Zeineb, S. Boussaid, S. Jemmali, S. Rahmouni, K. Zouaoui, H. Sahli, M. Elleuch
Journal: Annals of the Rheumatic Diseases (2022)

Background Spondylodiscitis is a chameleon among infectious diseases due to the lack of specific symptoms. In older patients, there are often difficulties in diagnosis and management. Objectives This retrospective study aimed to assess the characteristics of infectious spondylodiscitis in patients over 65 years of age. Methods This retrospective, monocentric study included patients aged over 65 years olds hospitalized in our department of rheumatology for spondylodiscitis. Results A total of 20 consecutive patients (10 males, 10 females) aged over 65 years were analyzed. The mean age of patients was 74 years (65-85). The most common comorbidities included diabetes (20%), chronic renal failure (5%). A history of nodal tuberculosis (10%), a tuberculosis contagion (30%), and raw milk ingestion (15%) were reported. The average delay for diagnosis was 10 months. The most common symptom was axial back pain (100% patients), then worsening health status (34%), and one patient had a significant neurological deficit. C-reactive protein was elevated in 95%. The most common involvement was in the lumbar vertebrae (13 patients, 65%), followed by thoracic and cervical level disease respectively in 3 patients (15%) and 2 patients (10%). Two patients (10%) had a multifocal spondylodiscitis. All patients underwent an MRI exam that confirmed the diagnosis. A percutaneous spine biopsy was performed in 80%. Pyogenic spondylodiscitis was the most common etiology (50%), followed by tuberculosis (35%) and brucellosis (15%). Antibiotic therapy was indicated to all patients with spinal immobilization in 65% of cases. Two patients underwent percutaneous drainage of paravertebral abscesses. The outcome was favorable in almost all cases until 12 months of following-up after completion of treatment. One patient died of septic shock and multi-visceral failure. Conclusion Elderly patients with infectious spondylodiscitis have fewer clinical symptoms leading to a delayed presentation. Increasing morbidity and mortality make rigorous monitoring necessary. Disclosure of Interests None declared
Cumulative seroprevalence among healthcare workers after the first wave of the COVID-19 pandemic in El Salvador, Central America
Authors: Yu Nakagama, Maria-Virginia Rodriguez-Funes, Rhina Dominguez, Katherine-Sofia Candray-Medina, Naoto Uemura, Evariste Tshibangu-Kabamba, Yuko Nitahara, Natsuko Kaku, Akira Kaneko, Yasutoshi Kido
Journal: Clinical Microbiology and Infection (2022)
AB0982 RISK OF OSTEOPORTIC FRACTURES IN POST-MENOPAUSE WOMEN WITH KNEE OSTEOARTHRITIS
Authors: O. Malyshenko, M. Letaeva, M. Koroleva, T. Raskina, J. Averkieva
Journal: Annals of the Rheumatic Diseases (2022)

Background Osteoporosis is an interdisciplinary problem, the medical and social significance of which is determined by its consequences: fractures of the vertebrae and bones of the peripheral skeleton. Objectives To estimate the 10-year probability of developing osteoporotic fractures in postmenopausal women with knee osteoarthritis (OA). Methods The study included 36 postmenopausal women (mean age 65.7±1.01 years). The main group consisted of 21 women with knee OA, the control group consisted of 15 women without OA. Bone mineral density (BMD) (g/cm2) and T-score (standard deviation, SD) of the femoral neck and lumbar spine (LI-LIV) were assessed by dual-energy X-ray absorptiometry (DXA) (Lunar Prodigy Primo, USA). The 10-year probability of developing major osteoporotic fractures (clinically significant vertebral fracture, distal forearm fracture, proximal femur fracture or shoulder fracture) and proximal femoral fracture was calculated using the FRAX calculator. Results Osteopenic syndrome in the study cohort was detected in 33 (91.7%) patients, including osteopenia in 18 (50.0%) women and osteoporosis in 15 (41.7%) women. Normal BMD was registered in 3 (8.3%) patients. In patients with knee OA osteopenic syndrome was registered in 19 (90.5%) patients: osteopenia - in 11 (52.4%), osteoporosis - in 8 (38.1%). In the control group, osteopenic syndrome was diagnosed in 13 (86.6%) people: osteopenia - in 6 (40.0%), osteoporosis - in 7 (46.7%). Normal BMD in both studied groups was determined only in 2 women (9.5% and 13.3%, respectively). There were no statistically significant differences in the structure of osteopenic syndrome among the studied groups (p=0.961). When analyzing the 10-year probability of developing major osteoporotic fractures, it was found that in women with OA of the knee, this probability was 12.4±0.91, in the control group it was 15.2±1.06 (p=0.085). The 10-year probability of a fracture of the proximal femur in women with knee OA was statistically significantly less than in the control group: 1.53(0.70;1.98) and 2.11(1.20;2.95), (p =0.031) respectively. Conclusion The overall incidence of osteopenic syndrome in the study cohort was 91.7%, with no statistically significant differences between the groups. The probability of developing a fracture of the proximal femur in women with knee OA was statistically significantly less than in the control group, while the risk of a 10-year fracture of the main localizations was comparable in the study groups. Disclosure of Interests None declared
AB0317 QUALITY OF LIFE AND LOCOMOTIVE FUNCTIONS IN PATIENTS WITH RHEUMATOID ARTHRITIS
Authors: O. Dobrovolskaya, O. Nikitinskaya, A. Feklistov, N. Demin, A. Sorokina, N. Toroptsova
Journal: Annals of the Rheumatic Diseases (2022)

Objectives To evaluate quality of life and its relationship with muscle strength and physical performance in patients with rheumatoid arthritis (RA). Methods 157 women with RA (median age was 58.6±8.8 years, median duration of RA was 8.0 [4,0; 14] years) were included in the study. Assessment of functional disability and quality of life was carried out using Health Assessment Questionnaire Disability Index (HAQ), EQ-5D (index and visual analog scale, VAS), Hospital Anxiety and Depression Scale (HADS, with two subscales for anxiety and depression, HADS-A and HADS-D), Rheumatoid Arthritis Impact of Disease (RAID). Also, all patients underwent tests to determine muscle strength by hand dynamometry and test “Chair stand” and physical performance by the Short Physical Performance Battery (SPPB). Dual-energy X-ray absorptiometry of the whole body, lumbar spine and proximal hip was done. Spearman’s correlation test was performed. Results 88.5% of RA patients had low muscle strength, 61.1% of people had low physical performance. No correlation was found between physical performance and age, RA activity, body composition and BMD. In persons with reduced physical performance, HAQ, EQ-5D index, VAS and RAID were worse than in women with normal physical function (p&lt;0.0001; p&lt;0.0001; p=0.004; p=0.010, respectively). Also, these patients had more pronounced signs of anxiety and depression, assessed using HADS-A (p=0.004) and HADS-D (p=0.001). HAQ positively correlated with the number of comorbidities (r=0.35, p&lt;0.001) and negatively correlated with the SPPB and gait speed (r=0.35, r=-0.39 and r=-0.37, respectively, p&lt;0.001). EQ-5D index positively correlated with SPPB and gate speed (r=0.44 and r=0.39, respectively, p&lt;0.001). HADS-A and HADS-D positively correlated with the number of comorbidities (r=0.35 and r=0.34, respectively, p&lt;0.001). HADS-A negatively correlated with the biological therapy duration (r=-0.36, p=0.032) and with BMI (r=-0.34, p&lt;0.001). HADS-D negatively correlated with the SPPB (r=-0.36, p&lt;0.001). RAID negatively correlated with the biological therapy duration (r=-0.35, p=0.032) and with SPPB (r=-0.35, p&lt;0.001). Conclusion 88.5% of RA patients had low muscle strength and 61.1% - low physical performance. Quality of life negatively correlated with physical performance. Disclosure of Interests None declared
AB1130 A REDUCTION IN NEW REFERRALS FOR RHEUMATOID ARTHRITIS, OSTEOARTHRITIS AND CRYSTAL ARTHRITIS COMPARED TO GCA DURING COVID19 PANDEMIC
Authors: M. Tormo-Ratera, M. Mirza, R. Luqmani
Journal: Annals of the Rheumatic Diseases (2022)

Background The COVID-19 pandemic has had profound effects on the Rheumatology department; we wanted to see if consequently referrals for Rheumatoid arthritis (RA), Crystal Arthritis (CA), Osteoarthritis (OA) and Giant cell arteritis (GCA) were affected. A greater understanding of the impact may enable adequate number of clinics and resources to be made available where needed. Objectives To evaluate the impact of COVID-19 pandemic on volume of new referrals to the Rheumatology department for RA, CA, OA and GCA. Methods A retrospective analysis of data was conducted from the period of January 2016 to December 2021. The Rheumatology department database was closely analysed and information about new referrals for GCA, RA, OA and CA were evaluated. Statistical analysis was conducted using t-test to compare the mean value pre and during the COVID19 outbreak (2020). Results From 2016 to 2021 a total number of 9998 new patients were referred to the Rheumatology department. There were 2768 new referrals for GCA (15%), RA (34%), OA (40%) and CA (11%) made during this period. In 2020, there was a significant decrease in OA, RA and CA referrals (p value 0.000004, 0.00017, 0.0042 respectively) but an insignificant decrease in GCA referrals (p value 0.243). Diagnoses Number of referrals p value Mean nº 2016-2019 2020 GCA 79.75 (14%) 63 (33%) 0.24334236 RA 204 (36%) 55 (28%) 0.000175427 OA 219.7 (39%) 59 (30%) 4.26975E-06 CA 64.5(11%) 18 (9%) 0.004278881 100% 100% Conclusion During COVID19 pandemic in 2020 there was a significant reduction in the number of new referrals for RA, OA, and CA in contrast to GCA where the referrals have been constant. This may be due to the detrimental consequences of untreated GCA with regards to risk of sight loss. However, with less RA referrals, this may result in a delayed diagnosis with an impact on the disease course. References [1]Kay L, Lanyon P, MacGregor A. February 2021. GIRFT Programme National Specialty Report. Available at: https://www.gettingitrightfirsttime.co.uk/wp- content/uploads/2021/08/Rheumatology-Jul21h-NEW.pdf [Accessed 9 th December 2021] [2]Romão VC, Cordeiro I, Macieira C, et al. Rheumatology practice amidst the COVID-19 pandemic: a pragmatic view.RMD Open 2020;6:e001314. doi: 10.1136/rmdopen-2020-001314 Disclosure of Interests None declared
AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids
Authors: Heiko Endle, Guilherme Horta, Bernardo Stutz, Muthuraman Muthuraman, Irmgard Tegeder, Yannick Schreiber, Isabel Faria Snodgrass, Robert Gurke, Zhong-Wu Liu, Matija Sestan-Pesa, Konstantin Radyushkin, Nora Streu, Wei Fan, Jan Baumgart, Yan Li, Florian Kloss, Sergiu Groppa, Nils Opel, Udo Dannlowski, Hans J. Grabe, Frauke Zipp, Bence Rácz, Tamas L. Horvath, Robert Nitsch, Johannes Vogt
Journal: Nature Metabolism (2022)