tbuckley/cabot-search huggingface dataset:
Clinical Unipolar Electrocardiography
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endoscopic therapy of sclerosing cholangitis
Authors: John G. Lee, Stephen M. Schutz, Ruth E. England, Joseph W. Leung, Peter B. Cotton
Journal: Hepatology (1995)

The efficacy of endoscopic treatment in primary sclerosing cholangitis has not been clearly established. This report presents endoscopic intervention in 53 consecutive patients with this disorder. Pertinent data were abstracted from the GI-TRAC database, medical records, and cholangiograms, and clinical follow-up was obtained by telephone interview of the subjects. Assessed treatment outcomes were clinical symptom, liver function test, and cholangiographic appearance. Between 1986 and 1993, 85 patients with primary sclerosing cholangitis underwent successful ERCP, of which 36 men and 17 women underwent 100 therapeutic endoscopic procedures. Forty-three of 50 dilations, 37 of 38 stentings, 8 of 8 nasobiliary tube placements, and 11 of 17 stone extractions were technically successful. These treatments were complicated by cholangitis or pancreatitis in 15 patients. Clinical follow-up was obtained in 50 of 53 patients who had undergone 85 procedures (median follow-up of 31 months): 28 patients felt better, 21 felt the same, and 1 felt worse. Liver function tests obtained within 3 months of the endoscopic treatment were significantly improved compared with pretreatment values (P < .001). Cholangiograms showed improvement in 36% of the patients, no change in 51%, and the effect of therapy could not be assessed in 13%. Overall, 41 of 53 patients (77%) had improvements of their clinical symptoms, liver function tests, or cholangiograms.
Familial Angioedema Associated With C1 Esterase-Inhibitor Deficiency
Authors: John T. Chiu
Journal: JAMA (1982)

In the absence of a positive family history for hereditary angioedema (HAE), both siblings in a family were found to have clinical and laboratory findings similar to those in HAE. Both siblings became symptom free after receiving danazol treatment, accompanied by a subnormal rise in C1 esterase inhibitor and C4 levels. As both siblings and their father share HLA haplotype A2,B7, the influence of other HLA loci on the clinical expression of this disorder should be considered. Although the disorder found in these siblings may be inherited as a recessive disorder, which to our knowledge has never been described before, or may have developed as the result of spontaneous genetic mutation, it is more appropriate to classify these two cases as familial angioedema until proved otherwise. (<i>JAMA</i>1982;247:1734-1736)
Functional Properties of Human Thymoma Lymphocytes: Role of Subcellular Factors in Blastic Activation&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Piero Musiani, Libero Lauriola, Nicola Maggiano, Pietro Tonali, Mauro Piantelli
Journal: JNCI Journal of the National Cancer Institute (1982)

The proliferative responses to phytohemagglutinin and the role of subcellular factors in the modulation of blastogenesis of thymoma lymphocytes from 5 thymoma patients were investigated. The addition of exogenous interleukin 1, a macrophage product, strongly augmented the blastic transformation of cultured thymocytes from both normal and neoplastic glands by influencing the production of interleukin 2 (IL-2) by a well-defined T-cell subset. The magnitudes of the blastic responses were ultimately modulated by the amount of IL-2 released in culture. The higher proliferative responses exhibited by thymocytes from thymoma were effectively sustained by a higher production of IL-2 in culture. In addition to having distinctive surface membrane receptors in common with normal thymocytes, thymoma lymphocytes were also under the influence of the same subcellular factors involved in T-cell blastic activation as thymocytes. These observations imply the presence of functionally distinct subpopulations in the thymoma lymphocyte component and add arguments in favor of their nonneoplastic nature.
Transdermal Scopolamine Psychosis
Authors: Richard K. Osterholm
Journal: JAMA (1982)

<h3>To the Editor.—</h3> Transderm-V (scopolamine) has recently been marketed in the United States as a treatment for motion sickness. It is a 2.5-cm-square, plastic disk with an adhesive surface that is placed on the skin behind the ear, where it releases 0.5 mg of scopolamine into the systemic circulation during a three-day period. Scopolamine and other cholinergic blocking agents have long been known to produce bothersome adverse effects such as mydriasis, dry mouth, drowsiness, urinary retention, constipation, and a toxic psychosis manifested as delirium, hallucinations, restlessness, and excitability. For this reason, scopolamine, despite its superior efficacy in preventing motion sickness, has been little used in comparison with the antiemetic antihistamines. The transdermal administration of scopolamine, however, has been reported to obviate most of the untoward effects. Drowsiness and dryness of the mouth are noted frequently, but few or no problems have been reported with the other effects. <h3>Report of a</h3>
The Occupational Physician and the Psychiatrist
Authors: Herbert C. Modlin
Journal: JAMA (1973)

Many of the misunderstandings, frustrations, and disappointments that arise in the relationship between occupational physicians and psychiatrists stem from the failure to recognize and fully understand that the two groups of physicians, while having much the same orientation, also operate in two different systems that require different modes of professional behavior. When both groups more clearly understand the different systems by which they operate and work together to evolve modes of bridging those two systems, a truthful and respectful medical partnership is evolved, from which the patient is sure to benefit.
Fellowships, Grants, Awards
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Fellowships, Grants, Awards Get access JNCI: Journal of the National Cancer Institute, Volume 85, Issue 14, 21 July 1993, Pages 1174–1175, https://doi.org/10.1093/jnci/85.14.1174 Published: 21 July 1993
IMMUNE CELL COOPERATION, VIRUSES, AND ANTIBODIES TO NUCLEIC ACIDS IN NEW ZEALAND MICE
Authors: Norman Talal, Alfred D. Steinberg, Michael E. Jacobs, Thomas M. Chused, Adi F. Gazdar
Journal: The Journal of Experimental Medicine (1971)

The development of autoimmunity in New Zealand mice is related to genetic, immunologic, and viral factors. Evidence is presented to suggest that thymus-dependent immune functions may be depressed and bone marrow-dependent functions augmented in these mice. Antibodies to RNA and DNA appear spontaneously and can also be induced by treatment with rI·rC. Antibodies binding rI·rC-14C in human lupus sera, in NZB/NZW F1 (B/W) mice developing lupus, and in NZB, ALN, and ALN/NZB mice have greatest specificity for reovirus double-stranded RNA. Treatment of B/W mice with RNA and cyclophosphamide induces immunologic tolerance, and suppresses antibodies binding rI·rC-14C. During recovery, the specificity of the antibodies is unaltered. Induction of tolerance in this way prevents the accelerated formation of anti-RNA antibodies normally induced by MLV. This finding suggests that virus-accelerated and natural disease occur through a similar mechanism, and supports the hypothesis that viruses may act as antigenic stimuli for a genetically hyper-responsive antibody-producing system.
Electron Microscopic Observations on RE Virus (Strain T) That Induces Reticuloendotheliosis in Turkeys, Chickens, and Japanese Quail
Authors: Robert F. Zeigel, Gordon H. Theilen, Marvin J. Twiehaus
Journal: JNCI Journal of the National Cancer Institute (1966)

The RE virus (strain T), an avian virus originally isolated from adult turkeys that induces reticuloendotheliosis in fowl, was studied by electron microscopy. Virus particles were observed that appeared to proliferate from connective tissue cells and from reticular and endothelial cells. Virus particles in endothelial cells budded directly into capillary lumens. The mature particles, approximately 100 mμ in diameter in thin section, had several characteristics shared by both the avian and murine leukosis viruses. Morphologically, the reticuloendotheliosis virus (RE virus) appeared different from other known avian viruses. This virus is basically similar to the cytoplasmically derived, RNA-containing viruses of the myxovirus group.
Cynicism Among Medical Students
Authors: Loretta Kopelman
Journal: JAMA (1983)

The thesis that medical students become more cynical than students of other professions seems justified in light of psychological studies and reports from medical students. This article explores whether this might be due, in part, to disappointment about how important ideals are followed. Psychological tests themselves offer an opportunity to examine this, because the medical profession espouses the goals of gaining proper consent from all subjects, including students, and of giving appropriate attention to excellence of research design and method. When studies used to evaluate medical students' attitudes are viewed from this perspective, however, weaknesses on both scores seem apparent. Students seem well aware of some of these flaws. Although such testing is a small part of medical education, it confirms students' views that there is cause for disillusionment about how certain goals are realized. It also suggests a way to cure some students' cynicism. Students should be taught consistently, both by example as well as by precept of their profession's sincere commitment to professed goals. In practical terms this means, for example, that studies using students as subjects should have a proper review by the institutional review board, with adequate attention given to excellence of design, confidentiality, and methods of gaining informed and unpressured consent. Such studies could then serve as paradigms to students. Other goals of the profession should also be applied to students, and applied for students. (<i>JAMA</i>1983;250:2006-2010)
An Improved System for Reporting Congenital Malformations
Authors: Stephen D. Minton
Journal: JAMA (1986)

To improve the system of reporting congenital malformations on the birth certificates of newborns, we initiated the following procedural changes at Utah Valley Regional Medical Center in 1981: (1) transference of the responsibility of reporting congenital malformations from the mother's physician to the newborn's physician; (2) development of a congenital malformation reporting sheet included in each newborn's file; and (3) appointment of a centralized single hospital medical records person to review the files and to complete the birth certificate. For 4949 births in 1982, the results of these changes were reviewed retrospectively and compared with those of a previous study at the institution. This system markedly improved the overall completeness of reporting while it identified inaccurate reporting of some malformations, incomplete reporting of multiple malformations, and the reporting of nonmalformations as congenital malformations. (<i>JAMA</i>1986;256:2976-2979)
Critical Elements in the Diagnosis of Alcoholism
Authors: William J. Filstead
Journal: JAMA (1976)

IT IS generally recognized that prolonged and excessive consumption of alcohol can have a deleterious effect on a person's physical health and psychosocial functioning. Yet, for a long time, there were no clearly identifiable criteria to diagnose alcoholism and to determine the extent and scope of any particular drinking pattern.<sup>1-6</sup> In an attempt to deal with this problem, the National Council on Alcoholism (NCA) established a criteria committee composed of prominent professionals in the field of alcoholism to define criteria for the diagnosis of alcoholism. The committee used as models diagnostic classifications developed in other areas of medicine<sup>7-11</sup>and also evaluated specific criteria used by alcoholism investigators.<sup>12</sup>The initial draft was sent to professionals in the alcoholism field for their comments and suggestions. The final draft consisted of two sets or tracks of criteria: Track 1 contains physiological and clinical items; track 2, behavioral, psychological, and attitudinal
Melanotic Lesions of the Eye in August Hooded Rats Induced by Urethan or &lt;italic&gt;N&lt;/italic&gt;-Hydroxyurethan Given During the Neonatal Period: A Histopathological Study&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: G. Kendrey, F. J. C. Roe
Journal: JNCI Journal of the National Cancer Institute (1969)

Beginning on the first day of life, inbred rats of the August hooded strain were given, at weekly intervals, a total of 8 subcutaneous injections of 1 mg/g body weight urethan (U) or N-hydroxyurethan (NHU). After 16 weeks, several rats developed macroscopically visible melanotic lesions of the eyes. All 15 U-treated males and 11 of 17 U-treated females that survived more than 16 weeks had melanotic lesions of one eye or both eyes. Of the NHU-treated rats surviving more than 16 weeks, 11 of 21 males and 11 of 21 females had melanotic lesions of one eye or both eyes. Histopathologically, the lesions were of two kinds, melanosis and melanoma. In different animals, they affected the iris, ciliary body, and/or choroid. None of 8 melanomas of the iris was invasive, but 2 of 3 melanomas of the choroid showed extension through the sclera. No distant metastases were seen.
Methadone Relatives And Substitutes
Authors: Max Fink
Journal: JAMA (1973)

<h3>To the Editor.—</h3> The report by Jaffe et al (222:437, 1972) is a careful study of methadyl acetate and methadone hydrochloride. Despite the apparent safety of methadyl acetate and its therapeutic equivalence three times a week for methadone daily, the authors choose to caution the reader with the warning, "however, in spite of these potential advantages, the unusual pharmacological actions of methadyl acetate could represent potential hazards." In our studies of a related compound, levomethadyl acetate (220:811, 1972), we were encouraged by our findings that levomethadyl administered three times a week was equivalent to methadone daily in safety, efficacy, and in our physiologic measures. We encouraged further trial of this compound, noting the early reports of some difficulties with methadyl acetate. We have since repeated our study of levomethadyl and affirmed its duration of action and safety. We believe that this compound deserves more extensive clinical trials. The public effort,
Studies on Leukocytes Growing in Continuous Culture Derived From Normal Human Donors&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Paul Gerber, Ph.D., James H. Monroe, Ph.D.
Journal: JNCI Journal of the National Cancer Institute (1968)

Continuous cultures of leukocytes from 6 normal human donors, designated NHDL cells, were established under controlled laboratory conditions. These autonomously growing cultures consist mainly of immature lymphoblastoid cells. The ultrastructural features of some of these cells are identical to those seen in human leukemic lymphoblasts. Four NHDL cell lines contained herpes-like virus (HLV) in 0.1–5.0% of the cells. These viruses are morphologically indistinguishable from HLV associated with certain Burkitt's lymphoma cell cultures. Attempts to isolate these viruses have been unsuccessful. Cross-immunofluorescence studies indicate a close antigenic relationship among HLVs present in Burkitt's tumors, NHDL cells, and normal chimpanzee leukocyte cultures.
Immunologic Response of Monkeys to Aerosols of Yaba Virus&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1968)

Complement-fixing and neutralizing antibody responses to Yaba virus were determined in 16 aerosol-exposed and 4 subcutaneously inoculated monkeys. The humoral response was similar after both routes of exposure when correlated with the course of tumor development. Comparable complement-fixing antibody titers were detected with subcutaneous tumor and lung tumor extracts as complement-fixing antigens, in contrast to the consistently lower titers obtained with infected cell culture preparations. The appearance and peak levels of complement-fixing and neutralizing antibody titers occurred simultaneously. Despite high neutralizing-antibody serum titers, 1 aerosol-exposed monkey developed multiple subcutaneous tumors at various intervals post exposure. Virus antigen was demonstrated in the cytoplasm of lung tumor cells by immunofluorescence. The fluorescent foci corresponded to the inclusion bodies observed light microscopically and ultrastructurally.
Celiprolol pneumonitis
Authors: JN Lombard, B Bonnotte, M Maynadie, P Foucher, O Reybet Degat, L Jeannin, P Camus
Journal: European Respiratory Journal (1993)

We report on a patient who developed hypersensitivity pneumonitis during treatment with the beta-blocker, celiprolol. The clinical picture was a severe alveolitis, with compromised gas exchange. Inadvertent subsequent rechallenge with celiprolol led to recurrence of the pneumonitis, 10 weeks after drug readministration. Again, the pneumonitis was fully reversible. Lymphocytes were elevated in bronchoalveolar lavage, and progressively normalized upon discontinuation of the drug. This case is reminiscent of pneumonitis to other beta-blockers, which are reviewed here.
A Text-Book of Pathology. With a Final Section on Post-Mortem Examinations and the Methods of Preserving and Examining Diseased Tissues.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Does Magnesium Prevent Myocardial Infarction?
Authors: James W. Nugent
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Gore and Dalen<sup>1</sup>state that the combined results of US and British physician studies demonstrate a 33% reduction in nonfatal myocardial infarction in male physicians who took aspirin compared with those who did not take aspirin. I believe combining the results of these two trials is misleading for two reasons. In the US physicians' study, there was a 44% decrease in nonfatal myocardial infarctions among aspirin takers.<sup>2</sup>But in the British study, there was no decrease.<sup>3</sup>The two trials do not support each other; they contradict each other. Combining results completely obscures this fact and makes it (wrongly) appear that the two trials drew similar conclusions. The treatments used in the two trials were not the same. In the British study, pure aspirin was used. In the US study, aspirin buffered with magnesium was used. The inclusion of magnesium may be significant. Numerous studies
Human Immunodeficiency Virus Infection in the United States
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Case of The Tussive Thief
Authors: Theodore A. Peterson
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Transthoracic Perforation of the bronchial system by foreign bodies and missiles is an uncommon occurrence in civilian medical practice. In the following report, a case of bronchial perforation is documented. <h3>Report of a Case:—</h3> A 24-year-old white man was brought by the County Emergency ambulance to the Hennepin County General Hospital after having been involved in a gun battle with the police. This followed an attempted robbery of a grocery store. The patient was admitted to the surgical station on Dec 17, 1966. He complained of discomfort in the right side of his chest and shortness of breath. There had been no cough or hemoptysis. The history was unremarkable. An appendectomy had been performed in 1964 at the Hennepin County General Hospital. A chest x-ray film, made at this time, was normal. Examination upon admission revealed a well appearing, somewhat dyspneic young man. The blood pressure was