tbuckley/cabot-search huggingface dataset:
TCT-334 Technical Analysis and Procedural Outcomes of Retrograde Approach to Chronic Total Occlusion Percutaneous Coronary Interventions: Insights From an International Multicenter Registry
Authors: Salman Allana, Spyridon Kostantinis, Athanasios Rempakos, Bahadir Simsek, Judit Karacsonyi, Khaldoon Alaswad, Farouc Jaffer, Jaikirshan Khatri, James Choi, Oleg Krestyaninov, Dmitrii Khelimskii, Sevket Gorgulu, Rhian Davies, Stewart Benton, Paul Poommipanit, Lorenzo Azzalini, Raj Chandwaney, Stephane Rinfret, Wissam Jaber, Jarrod Frizzell, Brian Jefferson, Yader Sandoval, Bavana Rangan, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2023)
TCT-354 The Clinical Impact of Dual Antiplatelet Therapy Score Combined With P2Y12 Reactivity Unit on East Asian Patients Who Received Drug-Eluting Stent Implantation: PTRG-DES Consortium
Authors: Seong Huan Choi, Sang-Don Park, Sung Woo Kwon, Yong-Soo Baek, Dae-Young Kim, Seung Hun Lee, David Hong, Ki Hong Choi, Joo Myung Lee, Taek Kyu Park, Jeong Hoon Yang, Joo-Yong Hahn, Seung-Hyuck Choi, Hyeon-Cheol Gwon, Myung Ho Jeong, Byeong-Keuk Kim, Hyung Joon Joo, Kiyuk Chang, Yongwhi Park, Sung Gyun Ahn, Jung-Won Suh, Sang Yeub Lee, Jung Rae Cho, Ae-Young Her, Hyo-Soo Kim, Moo Hyun Kim, Do-Sun Lim, Eun-Seok Shin, Young Bin Song, Young-Hoon Jeong
Journal: Journal of the American College of Cardiology (2023)
TCT-347 Mapping Out the Journey to TAVR in a Large Integrated Health System: Rates and Clinical Consequences of Delays in Referral of Severe Symptomatic Aortic Stenosis Patients to the Structural Heart Team Stratified by Gender, Ethnicity, and Socioeconomic Status
Authors: Benjamin Galper, Seohyun Kim, Jennifer Heliste, Megan Whitacre, Sundeep Basra, Lindsay Eberhart, Natalia Berry
Journal: Journal of the American College of Cardiology (2023)
TCT-372 Hemodynamic Performance of the Intra-Annular and the Supra-Annular Aortic Valves for Transcatheter Aortic Valve Replacement
Authors: Jeehoon Kang, Sungjoon Park, Minju Han, Doyeon Hwang, Jung-Kyu Han, Han-Mo Yang, Kyung Woo Park, Bon-Kwon Koo, Hyo-Soo Kim
Journal: Journal of the American College of Cardiology (2023)
TCT-342 Prognostic Implications of Quantitative Flow Ratio and Adverse Plaque Characteristics in Intravascular Ultrasound-Guided Revascularization Strategy
Authors: You-Jeong Ki, Jeehoon Kang, Doyeon Hwang, Hyo-Soo Kim, Bon-Kwon Koo
Journal: Journal of the American College of Cardiology (2023)
TCT-369 Age-Related Decrease in Absolute Microcirculatory Vasodilatory Capacity in Patients With Normal Coronary Arteries
Authors: Caïa Crooijmans, Nico Pijls, Valeria Paradies, Annemiek de Vos, Aukelien Dimitriu-Leen, Laura Rodwell, Niels van Royen, Pieter Smits, Peter Damman, Tijn Jansen
Journal: Journal of the American College of Cardiology (2023)
TCT-337 Safety Outcome Comparisons Between Balloon Pulmonary Angioplasty and Pulmonary Thromboendarterectomy in the Treatment of Chronic Thromboembolic Pulmonary Hypertension
Authors: Jacob Clarke, Ahmed Elkaryoni, Parth Desai, Elizabeth Bruno, Punit Arora, David Sutherland, Cathryn Sawalski, Waddah Malas, Parth Shah, Frances Greathouse, Muhammad Malik
Journal: Journal of the American College of Cardiology (2023)
TCT-329 The Pulmonary Artery Catheter, Next Generation: Real-Time Pressure-Volume Loops
Authors: Mohammed Aslam, Aleksandra Gruslova, Luis Diaz Sanmartin, Drew Nolen, James Elliott, Vivek Jani, Allen Anderson, Clay Heighten, Jonathan Valvano, Marc Feldman
Journal: Journal of the American College of Cardiology (2023)
TCT-357 Immediate Complete Revascularization in Patients Presenting With Acute Coronary Syndrome and Extensive Coronary Artery Disease: Insights From the BIOVASC Trial
Authors: Hala Kakar, Jacob Elscot, Paola Scarparo, Wijnand Den Dekker, Johan Bennett, Manel Sabate, Giovanni Esposito, Ignacio Amat-Santos, Michael Magro, Salvatore Brugaletta, Eric Boersma, Nicolas Van Mieghem, Roberto Diletti
Journal: Journal of the American College of Cardiology (2023)
TCT-366 Hyperoxemic Supersaturated Oxygen Therapy in Patients With Acute Anterior Myocardial Infarction Reduces Infarct Size and Microvascular Obstruction: A Cardiac Magnetic Resonance Imaging Analysis
Authors: Tobias Koenig, Dominik Berliner, Muharrem Akin, Carolina Sanchez Martinez, Johann Bauersachs, Andreas Schafer
Journal: Journal of the American College of Cardiology (2023)
TCT-349 Comparative Efficacy of Rotational Atherectomy With Cutting Ballon Versus Plain Balloon Preconditioning Before Drug-Eluting Stent Implantation in Calcified Coronary Lesions: An Updated Meta-Analysis
Authors: Usman Akbar, Ahmed Muaaz Umer, Nouman Shafique, Fnu Muhibullah, Qasim Khurshid, Abhi Lohana, Sarmad Zain, Shaheryar Qazi, Mounica Vorla, Abdul Qadeer, Muhammad Aslam Khan, Jawad Basit, Ahmad Ali Khan, Sourbha Dani
Journal: Journal of the American College of Cardiology (2023)
TCT-340 Sex Differences in Patients With 3-Vessel Coronary Artery Disease Undergoing FFR-Guided PCI or CABG: A Prespecified Analysis of the FAME 3 Trial
Authors: Kuniaki Takahashi, Hisao Otsuki, Frederik Zimmermann, Victoria Ding, Keith Oldroyd, Olaf Wendler, Michael Reardon, Joseph Woo, Alan Yeung, William Fearon
Journal: Journal of the American College of Cardiology (2023)
TCT-353 SavvyWire Efficacy and Safety in Transcatheter Aortic Valve Replacement Procedures Trial
Authors: Ander Regueiro, Alberto Alperi, Victoria Vilalta, Lluis Asmarats, Jose Antonio Baz Alonso, Luis Nombela-Franco, Alvaro Calabuig Goena, Antonio J. Muñoz-Garcia, Emilie Pelletier-Beaumont, Josep Rodes-Cabau
Journal: Journal of the American College of Cardiology (2023)
TCT-359 Preclinical Evaluation of a Novel Ultra-Thin Arsenic Trioxide-Tacrolimus Eluting Stent in Porcine Coronary Artery at 6 Months
Authors: Han Chen, Jiasheng Yin, Rui Wang, Changyi Zhou, Rende Xu, Li Shen, Junbo Ge
Journal: Journal of the American College of Cardiology (2023)
TCT-331 Cardiac Damage Staging Predicts Outcomes in Symptomatic and Asymptomatic Aortic Valve Stenosis After Aortic Valve Replacement: Meta-Analysis of Reconstructed Time-to-Event Data
Authors: Omar Abdelfattah, Xander Jacquemyn, Michel Pompeu Sá, Hani Jneid, Ibrahim Sultan, David Cohen, Linda Gillam, Marie-Annick Clavel, Philippe Pibarot, Samir Kapadia, Martin Leon, Philippe Généreux
Journal: Journal of the American College of Cardiology (2023)
TCT-328 Determining Beneficiaries of 2-Stent Strategy by BIFURCAT 2-Stent Score in a Large-Scale Coronary Bifurcation Registry
Authors: Albert Jang, Francesco Bruno, Minsu Kim, Leonardo De Luca, Kyounghoon Lee, Pyung Chun Oh, Joonpyo Lee, Gaetano De Ferrari, Seung Hwan Han, Fabrizio D'Ascenzo
Journal: Journal of the American College of Cardiology (2023)
TCT-343 Prognostic Impact of Morpho-Functional Assessment With Quantitative Flow Ratio and Optical Coherence Tomography in Patients With Acute Coronary Syndromes
Authors: Hiroyuki Kawamori, Takayoshi Toba, Takashi Hiromasa, Satoru Sasaki, Hiroyuki Fujii, Tomoyo Hamana, Tetsuya Yamamoto, Seigo Iwane, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Yuta Fukuishi, Hiroshi Tsunamoto, Koutaro Higuchi, Hiroya Okamoto, Masamichi Iwasaki, Amane Kozuki, Junya Shite, Tomofumi Takaya, Akihiko Ishida, Ken-ichi Hirata, Hiromasa Otake, Yuto Osumi
Journal: Journal of the American College of Cardiology (2023)
TCT-368 Optimal Timing of Invasive Strategy in Patients With High-Risk Non–ST-Segment Elevation Acute Coronary Syndrome: A Meta-Analysis
Authors: Dong-Woo Kim, Han-Young Jin, Jeong-Sook Seo, Tae-Hyun Yang, Dae-Kyeong Kim, Jae-Sik Jang
Journal: Journal of the American College of Cardiology (2023)
TCT-356 Patients With Moderate to Severe Lesion Tortuosity Undergoing Coronary Intervention With Newer-Generation Drug Eluting Stents: An Analysis From the Randomized BIOFLOW Trials
Authors: Rayyan Hemetsberger, Ralph Toelg, Mohammad Abdelghani, Serdar Farhan, Hector Manel Garcia-Garcia, Abdelhakim Allali, Stephan Windecker, Thierry Lefevre [retired], Shigeru Saito, David Kandzari, Ron Waksman
Journal: Journal of the American College of Cardiology (2023)
TCT-114 Insights Into In-Stent Restenosis From Optical Coherence Tomography in the RESTO Registry
Authors: Geraud Souteyrand, Thomas Mouyen, Benjamin Honton, Aurelien Mulliez, Benoit Lattuca, Jean-Guillaume Dillinger, Sebastien Levesque, Gregoire Range, Stephanie Marliere, Marine Quillot, Edouard Gerbaud, Nicolas Combaret, Pascal Motreff, Nicolas Amabile
Journal: Journal of the American College of Cardiology (2023)
TCT-118 Long-Term Outcomes in Patients With Chronic Total Occlusion
Authors: Daniel Gold, Pratik Sandesara, Matthew Gold, Nishant Vatsa, Shivang Desai, Malika Elhage Hassan, Chenyang Yuan, Yi-An Ko, Kiran Ejaz, Zain Alvi, Wissam Jaber, William Nicholson, Arshed Quyyumi
Journal: Journal of the American College of Cardiology (2023)
TCT-117 Long-Term Outcomes Following Treatment of Chronic Total Occlusions With the Use of Drug-Coated Balloons
Authors: Mehdi Madanchi, Eleonora Gnan, Giacomo Maria Cioffi, Varis Gjergjizi, Vanessa Bade, Adrian Attinger-Toller, Matthias Bossard, Florim Cuculi
Journal: Journal of the American College of Cardiology (2023)
TCT-112 Sex Differences in Long-Term Outcomes of Young Patients Undergoing Percutaneous Coronary Intervention: Long-Term Outcomes Analysis From a Multicenter Registry in Japan
Authors: Toshiki Kuno, Yoshihisa Miyamoto, Mitsuaki Sawano, Masaki Kodaira, Yohei Numasawa, Ikuko Ueda, Masahiro Suzuki, Shigetaka Noma, Keiichi Fukuda, Shun Kohsaka
Journal: Journal of the American College of Cardiology (2023)
TCT-109 Clinical Benefit of Intravascular Imaging Compared With Conventional Angiography in Left Main Coronary Artery Intervention
Authors: Woochan Kwon, Joo Myung Lee, Kyeong Ho Yun, Ki Hong Choi, Seung-Jae Lee, Jonng-Young Lee, Sang Yeub Lee, Sang Min Kim, Jae Young Cho, Chan Joon Kim, Hyo-Suk Ahn, Chang-Wook Nam, Hyuck-Jun Yoon, Yonghwan Park, Wang Soo Lee, Jin-Ok Jeong, Pil Sang Song, Sang-Ho Jo, Chang-Hwan Yoon, Min Gyu Kang, Kwan Yong Lee, Yun-Hyeong Cho, Jinman Cho, Woo Jin Jang, Kook-Jin Chun, David Hong, Taek Kyu Park, Jeong Hoon Yang, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Joo-Yong Hahn, Young Bin Song
Journal: Journal of the American College of Cardiology (2023)
TCT-105 Prognostic Significance of Nodular Calcification Derived From Noncontrast Coronary Computed Tomography Before Percutaneous Coronary Intervention
Authors: Seigo Iwane, Takayoshi Toba, Hiroyuki Kawamori, Takashi Hiromasa, Satoru Sasaki, Tomoyo Hamana, Hiroyuki Fujii, Yuto Osumi, Tetsuya Yamamoto, Hiroshi Tsunamoto, Shota Naniwa, Yuki Sakamoto, Yuta Fukuishi, Koshi Matsuhama, Koutaro Higuchi, Hiroya Okamoto, Yu Takahashi, Yu Izawa, Hiroyuki Yamamoto, Tomofumi Takaya, Ken-ichi Hirata, Hiromasa Otake
Journal: Journal of the American College of Cardiology (2023)
TCT-101 Temporal Trends in Right Ventricular to Pulmonary Artery Coupling in Patients Undergoing Transcatheter Mitral Valve-in-Valve Replacement for Degenerated Mitral Bioprostheses
Authors: Chen Chen, Vinesh Appadurai, Gloria Ayuba, James Flaherty, S. Chris Malaisrie, Zhiying Meng, Abigail Baldridge, Brody Slostad, Patrick McCarthy, Charles Davidson, Akhil Narang
Journal: Journal of the American College of Cardiology (2023)
TCT-104 Prognostic Impact of Ischemic Territory and Revascularization Strategy in Acute Myocardial Infarction Complicating Cardiogenic Shock Patients With Multivessel Disease
Authors: Sangyoon Lee, Ki Hong Choi, Jeong Hoon Yang, Taek Kyu Park, Joo Myung Lee, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Chul-Min Ahn, Cheol Woong Yu, Ik Hyun Park, Woo Jin Jang, Jang-Whan Bae, Sung Uk Kwon, Wang Soo Lee, Jin-Ok Jeong, Sang-Don Park, Tae Soo Kang, Hyeon-Cheol Gwon
Journal: Journal of the American College of Cardiology (2023)
TCT-102 Repeated Coronary Angiography in Elderly Patients With Previously Normal/Nonobstructive Coronary Angiography: Insights From a Retrospective Study
Authors: Ariel Roguin, Ofer Kobo, Simha Ron Meisel, Ziad Darawsha, Mahmood Odeh, Ahron Frimerman, Naama Amsalem, Rami Abu Fanne
Journal: Journal of the American College of Cardiology (2023)
TCT-103 Silent New-Onset Atrial Fibrillation After Transcatheter Aortic Valve Replacement
Authors: Jorge Nuche, Fady Soliman, Jorge Chavarria Viquez, Alexis Okoh, Hugo Alvarado Mora, Isabelle Nault, Francois Philippon, Madhu Natarajan, Mark Russo, Josep Rodés-Cabau
Journal: Journal of the American College of Cardiology (2023)
Bispecific CS1-BCMA CAR-T cells are clinically active in relapsed or refractory multiple myeloma
Authors: Chenggong Li, Jia Xu, Wenjing Luo, Danying Liao, Wei Xie, Qiuzhe Wei, Yinqiang Zhang, Xindi Wang, Zhuolin Wu, Yun Kang, Jin’e Zheng, Wei Xiong, Jun Deng, Yu Hu, Heng Mei
Journal: Leukemia (2023)

Abstract Multiple myeloma (MM) bears heterogeneous cells that poses a challenge for single-target immunotherapies. Here we constructed bispecific CS1-BCMA CAR-T cells aiming to augment BCMA targeting with CS1. Sixteen patients with relapsed or refractory (RR) MM received CS1-BCMA CAR-T infusion. Six patients (38%) had cytokine release syndrome, which was of grade 1–2 in 31%. No neurological toxicities were observed. The most common severe adverse events were hematological, including leukopenia (100%), neutropenia (94%), lymphopenia (100%) and thrombocytopenia (31%). Three patients with solitary extramedullary disease (sEMD) did not respond. At a median follow-up of 246 days, 13 patients (81%) had an overall response and attained minimal residual disease-negativity, and six (38%) reached a stringent complete response (sCR). Among the 13 responders, 1-year overall survival and progression-free survival were 72.73% and 56.26%, respectively. Four patients maintained sCR with a median duration of 17 months. Four patients experienced BCMA+ and CS1+ relapse or progression. One patient responded after anti-BCMA CAR-T treatment failure. Lenalidomide maintenance after CAR-T infusion and the resistance mechanism of sEMD were preliminarily explored in three patients. CAR-T cells persisted at a median of 406 days. Soluble BCMA could serve as an ideal biomarker for efficacy monitoring. CS1-BCMA CAR-T cells were clinically active with good safety profiles in patients with RRMM. Clinical trial registration: This study was registered on ClinicalTrials.gov, number NCT04662099.
Poly(ADP-ribose) Polymerase Inhibitor Combinations in First-Line Metastatic Castration-Resistant Prostate Cancer: Increasing Toxicity With Unclear Benefits
Authors: Ravi A. Madan, Fatima Karzai, David J. VanderWeele, Heather H. Cheng, Johann S. de Bono
Journal: Journal of Clinical Oncology (2023)

Positive phase III trials are not truly practice changing if they do not accurately inform on the best options for patients
Application of single wrist-wearable accelerometry for objective motor diary assessment in fluctuating Parkinson’s disease
Authors: Matthias Löhle, Jonathan Timpka, Alexander Bremer, Hamid Khodakarami, Florin Gandor, Malcom Horne, Georg Ebersbach, Per Odin, Alexander Storch
Journal: npj Digital Medicine (2023)

Advanced Parkinson's disease (PD) is characterized by motor fluctuations including unpredictable oscillations remarkably impairing quality of life. Effective management and development of novel therapies for these response fluctuations largely depend on clinical rating instruments such as the widely-used PD home diary, which are associated with biases and errors. Recent advancements in digital health technologies provide user-friendly wearables that can be tailored for continuous monitoring of motor fluctuations. Their criterion validity under real-world conditions using clinical examination as the gold standard remains to be determined. We prospectively examined this validity of a wearable accelerometer-based digital Parkinson's Motor Diary (adPMD) using the Parkinson's Kinetigraph (PKG®) in an alternative application by converting its continuous data into one of the three motor categories of the PD home diary (Off, On and Dyskinetic state). Sixty-three out of 91 eligible participants with fluctuating PD (46% men, average age 66) had predefined sufficient adPMD datasets (>70% of half-hour periods) from 2 consecutive days. 92% of per-protocol assessments were completed. adPMD monitoring of daily times in motor states showed moderate validity for Off and Dyskinetic state (ICC = 0.43-0.51), while inter-rating methods agreements on half-hour-level can be characterized as poor (median Cohen's κ = 0.13-0.21). Individualization of adPMD thresholds for transferring accelerometer data into diary categories improved temporal agreements up to moderate level for Dyskinetic state detection (median Cohen's κ = 0.25-0.41). Here we report that adPMD real-world-monitoring captures daily times in Off and Dyskinetic state in advanced PD with moderate validities, while temporal agreement of adPMD and clinical observer diary data is limited.
Immunologic Targets in AML
Authors: Jerome Ritz
Journal: Blood Cancer Discovery (2023)

In this issue of Blood Cancer Discovery, Nelde and colleagues used a sensitive mass spectrometry-based immunopeptidomics approach to characterize the antigenic landscape of acute myeloid leukemia (AML) and were able to identify immunogenic peptides presented by both leukemia stem cells (LSC) and bulk primary AML blasts. These immunogenic peptides elicit primarily CD4 T-cell responses and the diversity of the HLA class II immunopeptidome and presence of CD4 memory T-cell responses were both associated with improved clinical outcome. See related article by Nelde et al., p. 468 (1) .
Immune Surveillance of Acute Myeloid Leukemia Is Mediated by HLA-Presented Antigens on Leukemia Progenitor Cells
Authors: Annika Nelde, Heiko Schuster, Jonas S. Heitmann, Jens Bauer, Yacine Maringer, Melissa Zwick, Jens-Peter Volkmer, James Y. Chen, Anna M. Paczulla Stanger, Ariane Lehmann, Bismark Appiah, Melanie Märklin, Elke Rücker-Braun, Helmut R. Salih, Malte Roerden, Sarah M. Schroeder, Max-Felix Häring, Andreas Schlosser, Johannes Schetelig, Marc Schmitz, Melanie Boerries, Natalie Köhler, Claudia Lengerke, Ravindra Majeti, Irving L. Weissman, Hans-Georg Rammensee, Juliane S. Walz
Journal: Blood Cancer Discovery (2023)

Abstract Therapy-resistant leukemia stem and progenitor cells (LSC) are a main cause of acute myeloid leukemia (AML) relapse. LSC-targeting therapies may thus improve outcome of patients with AML. Here we demonstrate that LSCs present HLA-restricted antigens that induce T-cell responses allowing for immune surveillance of AML. Using a mass spectrometry–based immunopeptidomics approach, we characterized the antigenic landscape of patient LSCs and identified AML- and AML/LSC-associated HLA-presented antigens absent from normal tissues comprising nonmutated peptides, cryptic neoepitopes, and neoepitopes of common AML driver mutations of NPM1 and IDH2. Functional relevance of shared AML/LSC antigens is illustrated by presence of their cognizant memory T cells in patients. Antigen-specific T-cell recognition and HLA class II immunopeptidome diversity correlated with clinical outcome. Together, these antigens shared among AML and LSCs represent prime targets for T cell–based therapies with potential of eliminating residual LSCs in patients with AML. Significance: The elimination of therapy-resistant leukemia stem and progenitor cells (LSC) remains a major challenge in the treatment of AML. This study identifies and functionally validates LSC-associated HLA class I and HLA class II–presented antigens, paving the way to the development of LSC-directed T cell–based immunotherapeutic approaches for patients with AML. See related commentary by Ritz, p. 430 . This article is featured in Selected Articles from This Issue, p. 419
Loss of feedback regulation between FAM3B and androgen receptor driving prostate cancer progression
Authors: Tianfang Ma, Lianjin Jin, Shanshan Bai, Zhan Liu, Shuo Wang, Beibei Shen, Yeyoung Cho, Subing Cao, Meijuan J S Sun, Ladan Fazli, David Zhang, Chiyaro Wedderburn, Derek Y Zhang, Gavisha Mugon, Nathan Ungerleider, Melody Baddoo, Kun Zhang, Lovisa Holmberg Schiavone, Brant R Burkhardt, Jia Fan, Zongbing You, Erik K Flemington, Xuesen Dong, Yan Dong
Journal: JNCI Journal of the National Cancer Institute (2023)

Abstract Background Although the fusion of the transmembrane serine protease 2 gene (TMPRSS2) with the erythroblast transformation-specific-related gene (ERG), or TMPRSS2-ERG, occurs frequently in prostate cancer, its impact on clinical outcomes remains controversial. Roughly half of TMPRSS2-ERG fusions occur through intrachromosomal deletion of interstitial genes and the remainder via insertional chromosomal rearrangements. Because prostate cancers with deletion-derived TMPRSS2-ERG fusions are more aggressive than those with insertional fusions, we investigated the impact of interstitial gene loss on prostate cancer progression. Methods We conducted an unbiased analysis of transcriptome data from large collections of prostate cancer samples and employed diverse in vitro and in vivo models combined with genetic approaches to characterize the interstitial gene loss that imposes the most important impact on clinical outcome. Results This analysis identified FAM3B as the top-ranked interstitial gene whose loss is associated with a poor prognosis. The association between FAM3B loss and poor clinical outcome extended to fusion-negative prostate cancers where FAM3B downregulation occurred through epigenetic imprinting. Importantly, FAM3B loss drives disease progression in prostate cancer. FAM3B acts as an intermediator of a self-governing androgen receptor feedback loop. Specifically, androgen receptor upregulates FAM3B expression by binding to an intronic enhancer to induce an enhancer RNA and facilitate enhancer-promoter looping. FAM3B, in turn, attenuates androgen receptor signaling. Conclusion Loss of FAM3B in prostate cancer, whether through the TMPRSS2-ERG translocation or epigenetic imprinting, causes an exit from this autoregulatory loop to unleash androgen receptor activity and prostate cancer progression. These findings establish FAM3B loss as a new driver of prostate cancer progression and support the utility of FAM3B loss as a biomarker to better define aggressive prostate cancer.