tbuckley/cabot-search huggingface dataset:
Accreditation and the supply of physicians
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Potential role of two novel agonists of thyroid hormone receptor-beta on liver regeneration
Authors: Andrea Perra, Marta Anna Kowalik, Lavinia Cabras, Simona Onali, Cristina Migliore, Silvia Giordano, Grazia Chiellini, Simona Rapposelli, Amedeo Columbano
Journal: Journal of Hepatology (2020)
Energy levels and patient weight in ventricular defibrillation
Authors: J. A. Gascho
Journal: JAMA (1979)

In a prospective survey employing conventional devices that stored 400 joules or less, direct-current shocks that delivered 194±11 joules (1.8 joules/kg) to the chest wall terminated 45 of 46 episodes of ventricular fibrillation in 11 of 12 patients weighing 91 to 225 kg. Patients with coronary disease defibrillated more easily than patients without coronary disease. Weight did not determine outcome. The 98% defibrillation efficiency occurred at only half the energy predicted for 50% efficiency from retrospective data. Human defibrillation not only occurred at one third the untested level recommended by proponents of high-energy defibrillation, but also at one fourth the energy, defibrillating 69% of comparably heavy animals. Thus, the costly defibrillators delivering 400 to 800 joules now sold by 11 of 14 American manufacturers are superfluous, untested, potentially lethal devices with which to attempt ventricular defibrillation. (<i>JAMA</i>242:1380-1384, 1979).
Mucus and Surfactant Synthesis and Secretion by Cultured Hamster Respiratory Cells
Authors: Joel B. Baseman, Nancy S. Hayes, William E. Goldman, Albert M. Collier
Journal: Environmental Health Perspectives (1980)

Procedures for the selective isolation and cultivation in monolayer of respiratory cells have been developed. This technique requires repeated protease treatment and gradient centrifugation of hamster tracheal or lung tissues and permits the establishment of proliferating cultures of epithelial cells with biologic specialization. Mucus synthesis was monitored in cultured tracheal cells by incorporation of 3H-labeled N-acetyl-D-galactosamine and 14C-serine into glycoprotein as determined by trichloroacetic acid precipitation of growth medium followed by acrylamide gel electrophoresis. For comparative purposes tracheal explants and several established cell lines were also examined. Synthesis and secretion of the glycoprotein macromolecule by tracheal cell monolayers appeared to be regulated by vitamin A since its addition to the culture medium significantly increased both the number of cell-associated granules and glycoprotein secretion. Lung-originated cell cultures were grown to confluence and radio-labeled with 3H-choline in serum-free medium for 24 hr to examine surfactant synthesis. Cell monolayers and growth medium were then extracted by the Folch method, and total radioactive phosphatidylcholine as well as disaturated phosphatidylcholine were determined by thin-layer chromatography and alumina gel fractionation of osmium tetroxide-reactive phospholipid, respectively. Data indicate that these cultures have a marked ability to synthesize and secrete surfactant when compared to other established cell lines. In addition, naturally transformed cells that arose during passage and senescence of the primary cultures were analyzed for their biosynthetic capabilities.
Hookworm Anaemia
Authors: S. N. Salem
Journal: BMJ (1964)

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ALCOHOL AS A FOOD.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
04.07 Microrna-146a controls local bone destruction by regulating fibroblast induced osteoclastogenesis in inflammatory arthritis
Authors: Victoria Saferding, Antonia Puchner, Eliana Goncalves-Alves, Melanie Hofmann, Julia Brunner, Emine Sahin, Silvia Hayer, Phillipe Georgel, Marije M Koenders, Gernot Schabbauer, Josef S Smolen, Günter Steiner, Kurt Redlich, Stephan Blüml
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> MicroRNA (MiR-) 146a plays an important role in the regulation of the innate immune response and has also been shown to suppress cancer development in myeloid cells. Elevated expression of miR-146a has been detected in synovial tissue of rheumatoid arthritis patients, but its role in the development of inflammatory arthritis is still elusive. <h3>Materials and methods</h3> To induce arthritis we used the chronic inflammatory hTNFtg disease model, therefore we crossed miR-146a deficient into hTNFtg mice. Disease severity was assessed clinically and histologically. Blood of arthritis animals was analysed by flow cytometry. Serum cytokine levels were measured by Elisa. Synovial fibroblasts were isolated from metatarsal bones. Proliferation of fibroblasts was analysed histologically and by <sup>3</sup>[H]thymidine incorporation. RNA expression levels were measured by qPCR. <h3>Results</h3> When we crossed miR-146a<sup>-/-</sup> into hTNFtg mice, histological examination revealed a significant increase in synovial inflammation and even more striking a more than twofold increase in local bone destruction, due to increased generation of osteoclasts in the tarsal joints in miR-146a<sup>-/-</sup>/hTNFtg mice compared to hTNFtg mice. Interestingly, systemic bone loss was comparable in hTNFtg compared to miR-146a<sup>-/-</sup>/hTNFtg mice, suggesting an important local role of miR-146a. Indeed, we detected increased levels of IL-1β, TRAF6, a major target of miR-146a and RANKL, in addition the expression level of OPG was decreased locally in the paws of miR-146a<sup>-/-</sup>/hTNFtg compared to hTNFtg mice. By performing bone marrow transplants we could indeed show a pivotal role for miR-146a in mesenchymal cells in controlling local osteoclast generation and bone destruction. Analysis of important mesenchymal cells in arthritis, the synovial fibroblasts exhibited enhanced proliferation if miR-146a is missing, <i>in vitro</i> and <i>in vivo</i>. Moreover stimulation of these cells with IL-1β, a prominent cytokine in arthritis which was also shown to be negatively regulated by miR-146a, led to increased expression of RANKL and TRAF6 in miR-146a deficient synovial fibroblasts. <h3>Conclusion</h3> These data demonstrate an important mitigating role of the miR-146a in inflammatory arthritis, most importantly in local bone destruction, by controlling mesenchymal expression of osteoclastogenic factors. This shows an important anti-inflammatory role of miR-146a, which might possibly be exploited for therapeutic purposes.
The Bacterial Poisons.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of Angiotensin-Converting Enzyme Inhibitors in Heart Failure and Renal Insufficiency
Authors: Michael G. Shlipak
Journal: Annals of Internal Medicine (2004)

Letters1 June 2004Use of Angiotensin-Converting Enzyme Inhibitors in Heart Failure and Renal InsufficiencyMichael G. Shlipak, MD, MPHMichael G. Shlipak, MD, MPHFrom Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, CA 94121.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-11-200406010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I appreciate Dr. Ahmed's comments, and I agree that ACE inhibitors are likely to be beneficial in patients with systolic heart failure and renal insufficiency. The observational studies that demonstrate ACE inhibitor effectiveness in this setting are reassuring (1-3). However, subgroup analyses from randomized clinical trials of ACE inhibitors would add valuable and more definitive evidence to support the use of these agents in these patients.References1. Ahmed A, Kiefe CI, Allman RM, Sims RV, DeLong JF. Survival benefits of angiotensin-converting enzyme inhibitors in older heart failure patients with perceived contraindications. J Am Geriatr Soc. 2002;50:1659-66. [PMID: 12366619] CrossrefMedlineGoogle Scholar2. Frances CD, Noguchi H, Massie BM, Browner WS, McClellan M. Are we inhibited? Renal insufficiency should not preclude the use of ACE inhibitors for patients with myocardial infarction and depressed left ventricular function. Arch Intern Med. 2000;160:2645-50. [PMID: 10999979] CrossrefMedlineGoogle Scholar3. Shlipak MG, Browner WS, Noguchi H, Massie B, Frances CD, McClellan M. Comparison of the effects of angiotensin converting-enzyme inhibitors and beta blockers on survival in elderly patients with reduced left ventricular function after myocardial infarction. Am J Med. 2001;110:425-33. [PMID: 11331052] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, CA 94121. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPharmacotherapy for Heart Failure in Patients with Renal Insufficiency Michael G. Shlipak Use of Angiotensin-Converting Enzyme Inhibitors in Heart Failure and Renal Insufficiency Ali Ahmed Metrics 1 June 2004Volume 140, Issue 11Page: 932KeywordsACE inhibitorsAngiotensin converting enzyme inhibitorHeart failureObservational studiesRenal failure ePublished: 1 June 2004 Issue Published: 1 June 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Toxicity of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex
Authors: Douglas D. Richman, Margaret A. Fischl, Michael H. Grieco, Michael S. Gottlieb, Paul A. Volberding, Oscar L. Laskin, John M. Leedom, Jerome E. Groopman, Donna Mildvan, Martin S. Hirsch, George G. Jackson, David T. Durack, Sandra Nusinoff-Lehrman
Journal: New England Journal of Medicine (1987)

We conducted a double-blind, placebo-controlled trial of oral azidothymidine (AZT) in 282 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex. Although significant clinical benefit was documented (N Engl J Med 1987; 317:185–91), serious adverse reactions, particularly bone marrow suppression, were observed. Nausea, myalgia, insomnia, and severe headaches were reported more frequently by recipients of AZT; macrocytosis developed within weeks in most of the AZT group. Anemia with hemoglobin levels below 7.5 g per deciliter developed in 24 percent of AZT recipients and 4 percent of placebo recipients (P<0.001). Twenty-one percent of AZT recipients and 4 percent of placebo recipients required multiple red-cell transfusions (P<0.001). Neutropenia (<500 cells per cubic millimeter) occurred in 16 percent of AZT recipients, as compared with 2 percent of placebo recipients (P<0.001). Subjects who entered the study with low CD4 lymphocyte counts, low serum vitamin B12 levels, anemia, or low neutrophil counts were more likely to have hematologic toxic effects. Concurrent use of acetaminophen was also associated with a higher frequency of hematologic toxicity. Although a subset of patients tolerated AZT for an extended period with few toxic effects, the drug should be administered with caution because of its toxicity and the limited experience with it to date. (N Engl J Med 1987; 317:192–7.)
Solving Immunology?
Authors: Yoram Vodovotz, Ashley Xia, Elizabeth L. Read, Josep Bassaganya-Riera, David A. Hafler, Eduardo Sontag, Jin Wang, John S. Tsang, Judy D. Day, Steven H. Kleinstein, Atul J. Butte, Matthew C. Altman, Ross Hammond, Stuart C. Sealfon
Journal: Trends in Immunology (2016)
Growth Factors
Authors: DAVID W. GOLDE
Journal: Annals of Internal Medicine (1980)

Humoral regulation of somatic and hematopoietic cell growth has been intensely investigated during the past decade. Growth hormone is unique because it regulates the size of the person within the constraints of the genetic program. The somatomedins and insulin growth factors are low molecular weight polypeptides believed to mediate some functions of growth hormone. Epithelial growth factor and nerve growth factor are well-characterized polypeptides that influence the growth and differentiation of epithelial and neural tissues and interact with specific cell surface receptors. The hematopoietins are a family of polypeptide hormones that specifically regulate the proliferation and differentiation of stem cells giving rise to erythrocytes, granulocytes, monocytes, megakaryocytes, and B and T lymphocytes. Platelet-derived growth factor modulates the proliferation of fibroblasts in vitro and may have a role in the development of atherosclerosis and myelofibrosis. New knowledge on the biochemistry and physiology of growth factors will probably have a substantial impact on our understanding of human diseases involving abnormal cell growth.
Signs
Authors: Rae Varcoe
Journal: Annals of Internal Medicine (2004)

Ad Libitum5 October 2004SignsRae Varcoe, MA, MB, ChB, FRACP, FRCPARae Varcoe, MA, MB, ChB, FRACP, FRCPAFrom Auckland Hospital, Auckland 1, New Zealand.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-7-200410050-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I sit by his side for a long timehe's six feet six on a hospital bedhis feet are suspended in spaceby day he's a signwriterhe's six feet six on a hospital bedat night he's a DJby day he's a signwriterhis first chemo was ABVDat night he's a DJhe relapsed at twelve monthshis first chemo was ABVDthin digits finger his tumourhe relapsed at twelve monthshe's just had more treatmentthin digits finger his tumourhe says the lump is smallerhe's just had more treatmentmy ruler states the truthhe says the lump is smallerthe signwriter does not read the signs... Author, Article, and Disclosure InformationAffiliations: From Auckland Hospital, Auckland 1, New Zealand.Current Author Address: Rae Varcoe, MA, MB, ChB, FRACP, FRCPA, Auckland Hospital, Park Road, Private Bag 92024, Auckland 1, New Zealand. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 October 2004Volume 141, Issue 7Page: 572 ePublished: 5 October 2004 Issue Published: 5 October 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
DTP Vaccine
Authors: Joel S. Samuelson
Journal: JAMA (1986)

<h3>To the Editor.—</h3> In their latest recommendations regarding the diphtheria and tetanus toxoids and pertussis (DTP) vaccines, the Centers for Disease Control provide an excellent review.<sup>1</sup>The DTP vaccine has been the subject of widespread controversy. Recent prospective data have shown a high incidence of immediate adverse reactions and long-term sequelae temporally associated with the vaccine.<sup>1,2</sup>This has resulted in some parents requesting that the pertussis component be omitted from routine immunization. In response to the growing concern about the acceptability of DTP vaccine, we conducted a study to investigate the validity of reduced-dose immunizations with DTP vaccine.<sup>3</sup>Many clinicians have empirically adopted this approach in response to parental anxiety. The study demonstrated that a reduced-dose series of three primary immunizations and a booster with DTP vaccine provided equivalent antibody response, while significantly reducing the incidence and severity of adverse reactions. Febrile and local reactions were reduced
Spontaneous subcapsular splenic hematoma as the only clinical manifestation of infectious mononucleosis
Authors: J. M. Patel
Journal: JAMA (1982)

SPONTANEOUS rupture of the spleen due to infectious mononucleosis was first reported by King<sup>1</sup>in 1941. Of 107 reported cases of splenic rupture associated with infectious mononucleosis, only 18 are considered to be true spontaneous ruptures.<sup>2</sup>This is the report of a symptomatic, unruptured subcapsular hematoma in a patient with a high heterophil antibody titer and no other signs or symptoms. Two patients in a series of 500 consecutive cases of infectious mononucleosis probably had subcapsular splenic hematoma.<sup>3</sup> <h3>Report of a Case</h3> A 20-year-old man was asymptomatic except for the sudden onset of left upper quadrant abdominal pain. When examined in the emergency room on April 25, 1979, his left upper abdomen was mildly tender, but there were no other pertinent findings except for a hematocrit reading of 38% and a hemoglobin level of 13.6 g/dL. Three days later, he was admitted because of persistent abdominal pain
A Two-Gene Classifier for Predicting Response to the Farnesyltransferase Inhibitor Tipifarnib in Acute Myeloid Leukemia.
Authors: Mitch Raponi, Jeffrey E. Lancet, Hongtao Fan, Lesley Dossey, Grace Lee, Ivana Gojo, Eric J. Feldman, Jason Gotlib, Lawrence E. Morris, Peter L. Greenberg, John J. Wright, Jean-Luc Harousseau, Bob Lowenberg, Richard M. Stone, Peter De Porre, Yixin Wang, Judith E. Karp
Journal: Blood (2007)
Cytologic Manifestations of Cervical and Vaginal Infections
Authors: Nancy B. Kiviat
Journal: JAMA (1985)

We found inflammatory patterns of transparent lymphocytes on increased numbers of histiocytes suggestive of chlamydial infection in 68 (56%) of 121 cervical cytologic smears.<i>Chlamydia trachomatis</i>was isolated from 36 (53%) of those with and only two (4%) of those without such inflammatory patterns. Direct stain with fluorescein-conjugated monoclonal antibodies demonstrated elementary bodies of<i>C trachomatis</i>in 30 (79%) of the 38 culture-positive patients, including 29 of the culture-positive patients who had an inflammatory cytologic pattern suggestive of<i>C trachomatis</i>infection. Thus, Papanicolaou smears can be screened for inflammatory pattern, and separate endocervical smears from patients with a pattern suggestive of chlamydial infection can then be stained by immunofluorescence to confirm the presence of<i>C trachomatis</i>infection. This two-step approach detected 29 of 38 infections confirmed by culture in the present study, giving a sensitivity of 76%, a specificity of 100%, and a positive predictive value of 100% in a population having a 31% prevalence of<i>C trachomatis</i>infection. (<i>JAMA</i>1985;253:997-1000)
Reply
Authors: H. Moseley, R.M. Mackie, J. Ferguson
Journal: British Journal of Dermatology (1994)

Journal Article Reply Get access H. Moseley, H. Moseley West of Scotland Health Boards, Department of Clinical Physics and Bioengineering, 22 Western Court, 100 University Place, Glasgow G12 8SQ, U.K. Search for other works by this author on: Oxford Academic Google Scholar R.M. Mackie, R.M. Mackie Department of Dermatology, University of Glasgow, Anderson College Building, 56 Dumbarton Road, Glasgow G11 6NW, U.K. Search for other works by this author on: Oxford Academic Google Scholar J. Ferguson J. Ferguson Photobiology Unit, Ninewells Hospital, Dundee DD1 9SY, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 131, Issue 6, 1 December 1994, Pages 912–913, https://doi.org/10.1111/j.1365-2133.1994.tb08603.x Published: 01 December 1994