tbuckley/cabot-search huggingface dataset:
Challenges and new technologies in adoptive cell therapy
Authors: Pengchao Zhang, Guizhong Zhang, Xiaochun Wan
Journal: Journal of Hematology & Oncology (2023)

Abstract Adoptive cell therapies (ACTs) have existed for decades. From the initial infusion of tumor-infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and chimeric antigen receptor (CAR)-T cell therapies, many novel strategies for cancer treatment have been developed. Owing to its promising outcomes, CAR-T cell therapy has revolutionized the field of ACTs, particularly for hematologic malignancies. Despite these advances, CAR-T cell therapy still has limitations in both autologous and allogeneic settings, including practicality and toxicity issues. To overcome these challenges, researchers have focused on the application of CAR engineering technology to other types of immune cell engineering. Consequently, several new cell therapies based on CAR technology have been developed, including CAR-NK, CAR-macrophage, CAR-γδT, and CAR-NKT. In this review, we describe the development, advantages, and possible challenges of the aforementioned ACTs and discuss current strategies aimed at maximizing the therapeutic potential of ACTs. We also provide an overview of the various gene transduction strategies employed in immunotherapy given their importance in immune cell engineering. Furthermore, we discuss the possibility that strategies capable of creating a positive feedback immune circuit, as healthy immune systems do, could address the flaw of a single type of ACT, and thus serve as key players in future cancer immunotherapy.
Dexamethasone for the Treatment of Tuberculous Meningitis in Adolescents and Adults
Authors: Guy E. Thwaites, Nguyen Duc Bang, Nguyen Huy Dung, Hoang Thi Quy, Do Thi Tuong Oanh, Nguyen Thi Cam Thoa, Nguyen Quang Hien, Nguyen Tri Thuc, Nguyen Ngoc Hai, Nguyen Thi Ngoc Lan, Nguyen Ngoc Lan, Nguyen Hong Duc, Vu Ngoc Tuan, Cao Huu Hiep, Tran Thi Hong Chau, Pham Phuong Mai, Nguyen Thi Dung, Kasia Stepniewska, Nicholas J. White, Tran Tinh Hien, Jeremy J. Farrar
Journal: New England Journal of Medicine (2004)

Tuberculous meningitis kills or disables more than half of those affected with the disease. Previous studies have been too small to determine whether adjunctive treatment with corticosteroids can reduce the risk of disability or death among adults with tuberculous meningitis, and the effect of coinfection with the human immunodeficiency virus (HIV) is unclear.
Cigarette Smoking Among Adults—United States, 2007
Journal: JAMA (2009)

cine.December 8-14 is National Influenza Vaccination Week.Health-care providers are encouraged to take advantage of heightened awareness of the benefits of influenza vaccination and to increase vaccination efforts during this week to reach persons who have not yet been vaccinated.CDC continues to conduct surveillance to provide up-to-date recommendations regarding prevention and treatment of influenza.Influenza surveillance reports for the United States are posted online weekly during October-May and are available at http://www.cdc.gov/flu/weekly/fluactivity.htm.
Alum-tuned hyaluronic acid-based hydrogel with immune checkpoint inhibition for immunophoto therapy of cancer
Authors: Sungyun Kim, Jae-Hee Ahn, Da In Jeong, Mingyu Yang, Jae-Hyeon Jeong, Yeoung Eun Choi, Hyun Jin Kim, Youngjoo Han, Mrinmoy Karmakar, Hyun-Jeong Ko, Hyun-Jong Cho
Journal: Journal of Controlled Release (2023)
Biomimetic Fibers Based on Equidistant Micropillar Arrays Determines Chondrocyte Fate via Mechanoadaptability
Authors: Chenchen Zhou, Yueyi Yang, Mengmeng Duan, Cheng Chen, Caixia Pi, Demao Zhang, Xiaoheng Liu, Jing Xie
Journal: Advanced Healthcare Materials (2023)

It is recognized that the changes in the physical properties of extracellular matrix (ECM) result in fine-tuned cell responses including cell morphology, proliferation and differentiation. In this study, a novel patterned equidistant micropillar substrate based on polydimethylsiloxane (PDMS) is designed to mimic the collagen fiber-like network of the cartilage matrix. By changing the component of the curing agent to an oligomeric base, micropillar substrates with the same topology but different stiffnesses are obtained and it is found that chondrocytes seeded onto the soft micropillar substrate maintain their phenotype by gathering type II collagen and aggrecan more effectively than those seeded onto the stiff micropillar substrate. Moreover, chondrocytes sense and respond to micropillar substrates with different stiffnesses by altering the ECM-cytoskeleton-focal adhesion axis. Further, it is found that the soft substrate-preserved chondrocyte phenotype is dependent on the activation of Wnt/β-catenin signaling. Finally, it is indicated that the changes in osteoid-like region formation and cartilage phenotype loss in the stiffened sclerotic area of osteoarthritis cartilage to validate the changes triggered by micropillar substrates with different stiffnesses. This study provides the cell behavior changes that are more similar to those of real chondrocytes at tissue level during the transition from a normal state to a state of osteoarthritis.
A photo-activable nano-agonist for the two-signal model of T cell in vivo activation
Authors: Yuchan You, Feiyang Jin, Yan Du, Luwen Zhu, Di Liu, Minxia Zhu, Yuyin Du, Jialu Lang, Weishuo Li, Jian-Song Ji, Yong-Zhong Du
Journal: Journal of Controlled Release (2023)
Comment on ‘Treatment of moderate-to-severe alopecia areata in preadolescent children with baricitinib’: authors’ reply
Authors: Leila Asfour, Laita Bokhari, Bevin Bhoyrul, Samantha Eisman, Anthony Moussa, Huw Rees, Rodney D Sinclair
Journal: British Journal of Dermatology (2023)

In this response to a recent article on the off-label use of baricitinib for paediatric alopecia areata (AA), we raise additional points regarding the relationship between viral infections and AA relapse on Janus kinase inhibitor (JAKi) therapy, and the potential benefits of concomitant oral minoxidil therapy in mitigating the risk of relapse during JAKi dose reduction or discontinuation.
Neonatal screening for lysosomal storage disorders: feasibility and incidence from a nationwide study in Austria
Authors: Thomas P Mechtler, Susanne Stary, Thomas F Metz, Víctor R De Jesús, Susanne Greber-Platzer, Arnold Pollak, Kurt R Herkner, Berthold Streubel, David C Kasper
Journal: The Lancet (2012)
Engineered porosity for tissue-integrating, bioresorbable lifetime-based phosphorescent oxygen sensors
Authors: Kayla F. Presley, Thomas Falcucci, Sawnaz Shaidani, Vincent Fitzpatrick, Jonah Barry, Jack T. Ly, Matthew J. Dalton, Tod A. Grusenmeyer, David L. Kaplan
Journal: Biomaterials (2023)
Joint pain in patients with atopic dermatitis receiving treatment with dupilumab: A US nationwide cohort study
Authors: Maria C. Schneeweiss, Richard Wyss, Sebastian Schneeweiss, Priyanka Anand, Yinzhu Jin, Elyse Dicesare, Robert J. Glynn, Joseph F. Merola
Journal: Journal of the American Academy of Dermatology (2023)
Exploiting the fibroblast growth factor receptor-1 vulnerability to therapeutically restrict the MYC-EZH2-CDKN1C axis-driven proliferation in Mantle cell lymphoma
Authors: Anuvrat Sircar, Satishkumar Singh, Zijun Y. Xu-Monette, Krysta Mila Coyle, Laura K. Hilton, Evangelia Chavdoula, Parvathi Ranganathan, Neeraj Jain, Walter Hanel, Philip Tsichlis, Lapo Alinari, Blake R. Peterson, Jianguo Tao, Natarajan Muthusamy, Robert Baiocchi, Narendranath Epperla, Ken H. Young, Ryan Morin, Lalit Sehgal
Journal: Leukemia (2023)

Abstract Mantle cell lymphoma (MCL) is a lethal hematological malignancy with a median survival of 4 years. Its lethality is mainly attributed to a limited understanding of clinical tumor progression and resistance to current therapeutic regimes. Intrinsic, prolonged drug treatment and tumor-microenvironment (TME) facilitated factors impart pro-tumorigenic and drug-insensitivity properties to MCL cells. Hence, elucidating neoteric pharmacotherapeutic molecular targets involved in MCL progression utilizing a global “unified” analysis for improved disease prevention is an earnest need. Using integrated transcriptomic analyses in MCL patients, we identified a Fibroblast Growth Factor Receptor-1 (FGFR1), and analyses of MCL patient samples showed that high FGFR1 expression was associated with shorter overall survival in MCL patient cohorts. Functional studies using pharmacological intervention and loss of function identify a novel MYC-EZH2-CDKN1C axis-driven proliferation in MCL. Further, pharmacological targeting with erdafitinib, a selective small molecule targeting FGFRs, induced cell-cycle arrest and cell death in-vitro, inhibited tumor progression, and improved overall survival in-vivo. We performed extensive pre-clinical assessments in multiple in-vivo model systems to confirm the therapeutic potential of erdafitinib in MCL and demonstrated FGFR1 as a viable therapeutic target in MCL.
Mechanisms of radiotherapy resistance and radiosensitization strategies for esophageal squamous cell carcinoma
Authors: Lingbo An, Mingyang Li, Qingge Jia
Journal: Molecular Cancer (2023)

Abstract Esophageal squamous cell carcinoma (ESCC) is the sixth most common cause of cancer-related mortality worldwide, with more than half of them occurred in China. Radiotherapy (RT) has been widely used for treating ESCC. However, radiation-induced DNA damage response (DDR) can promote the release of cytokines and chemokines, and triggers inflammatory reactions and changes in the tumor microenvironment (TME), thereby inhibiting the immune function and causing the invasion and metastasis of ESCC. Radioresistance is the major cause of disease progression and mortality in cancer, and it is associated with heterogeneity. Therefore, a better understanding of the radioresistance mechanisms may generate more reversal strategies to improve the cure rates and survival periods of ESCC patients. We mainly summarized the possible mechanisms of radioresistance in order to reveal new targets for ESCC therapy. Then we summarized and compared the current strategies to reverse radioresistance.
Correction: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance
Authors: Tao Zhang, Rong Qu, Shingpan Chan, Mengzhen Lai, Linjiang Tong, Fang Feng, Hongyu Chen, Tingting Song, Peiran Song, Gang Bai, Yingqiang Liu, Yanan Wang, Yan Li, Yi Su, Yanyan Shen, Yiming Sun, Yi Chen, Meiyu Geng, Ke Ding, Jian Ding, Hua Xie
Journal: Molecular Cancer (2023)

the authors do notice that they mis-claimed the qRT-PCR primers that predicted to target human CDH10 gene as specific primers targeting human BIM gene in
An exploratory comparative case series of calcitonin gene-related peptide monoclonal antibodies in patients with migraine with rosacea
Authors: Twan Sia, Taylor Webb, Shufeng Li, Leon S Moskatel, Anne Lynn S Chang
Journal: British Journal of Dermatology (2023)

Rosacea is associated with &amp;gt; 50% of cases of migraine. Recent data have shown that calcitonin gene-related peptide (CGRP) is elevated in rosacea skin. CGRP monoclonal antibodies (mAbs) prevent migraine with known safety profiles, but their effect on rosacea is not known. This exploratory retrospective study examined rosacea in patients with migraines, before and after CGRP mAbs. Of 13 eligible patients on stable or unchanged concurrent rosacea medications, the majority experienced improvement after receiving CGRP mAbs. Mean (SD) rosacea severity scores for the periods before and while on CGRP mAbs were, respectively, 1.19 (0.65) and 0.58 (0.70) (P = 0.01). Prospective, placebo-controlled clinical trials are needed to further assess the use of CGRP mAbs in rosacea.
The Supreme Court and the Importance of Diversity in Medicine
Authors: Clyde W. Yancy, Gilda Barabino, Cedric Bright, Cato T. Laurencin, Valerie Montgomery Rice
Journal: New England Journal of Medicine (2023)

Interview with Valerie Montgomery Rice on opportunities for achieving a diverse student body and workforce after the Supreme Court’s decision on affirmative action. (11:32)Download The Supreme Court’s decisions in two cases eliminate the consideration of race in university admissions. Regardless of the rulings, medical education can sustain efforts supporting diversity.
Predicting HPV association using deep learning and regular H&amp;E stains allows granular stratification of oropharyngeal cancer patients
Authors: Sebastian Klein, Nora Wuerdemann, Imke Demers, Christopher Kopp, Jennifer Quantius, Arthur Charpentier, Yuri Tolkach, Klaus Brinker, Shachi Jenny Sharma, Julie George, Jochen Hess, Fabian Stögbauer, Martin Lacko, Marijn Struijlaart, Mari F.C.M. van den Hout, Steffen Wagner, Claus Wittekindt, Christine Langer, Christoph Arens, Reinhard Buettner, Alexander Quaas, Hans Christian Reinhardt, Ernst-Jan Speel, Jens Peter Klussmann
Journal: npj Digital Medicine (2023)

Abstract Human Papilloma Virus (HPV)-associated oropharyngeal squamous cell cancer (OPSCC) represents an OPSCC subgroup with an overall good prognosis with a rising incidence in Western countries. Multiple lines of evidence suggest that HPV-associated tumors are not a homogeneous tumor entity, underlining the need for accurate prognostic biomarkers. In this retrospective, multi-institutional study involving 906 patients from four centers and one database, we developed a deep learning algorithm (OPSCCnet), to analyze standard H&amp;E stains for the calculation of a patient-level score associated with prognosis, comparing it to combined HPV-DNA and p16-status. When comparing OPSCCnet to HPV-status, the algorithm showed a good overall performance with a mean area under the receiver operator curve (AUROC) = 0.83 (95% CI = 0.77-0.9) for the test cohort ( n = 639), which could be increased to AUROC = 0.88 by filtering cases using a fixed threshold on the variance of the probability of the HPV-positive class - a potential surrogate marker of HPV-heterogeneity. OPSCCnet could be used as a screening tool, outperforming gold standard HPV testing (OPSCCnet: five-year survival rate: 96% [95% CI = 90–100%]; HPV testing: five-year survival rate: 80% [95% CI = 71–90%]). This could be confirmed using a multivariate analysis of a three-tier threshold (OPSCCnet: high HR = 0.15 [95% CI = 0.05–0.44], intermediate HR = 0.58 [95% CI = 0.34–0.98] p = 0.043, Cox proportional hazards model, n = 211; HPV testing: HR = 0.29 [95% CI = 0.15–0.54] p &lt; 0.001, Cox proportional hazards model, n = 211). Collectively, our findings indicate that by analyzing standard gigapixel hematoxylin and eosin (H&amp;E) histological whole-slide images, OPSCCnet demonstrated superior performance over p16/HPV-DNA testing in various clinical scenarios, particularly in accurately stratifying these patients.
Predicting labor onset relative to the estimated date of delivery using smart ring physiological data
Authors: Elise N. Erickson, Neta Gotlieb, Leonardo M. Pereira, Leslie Myatt, Clara Mosquera-Lopez, Peter G. Jacobs
Journal: npj Digital Medicine (2023)

The transition from pregnancy into parturition is physiologically directed by maternal, fetal and placental tissues. We hypothesize that these processes may be reflected in maternal physiological metrics. We enrolled pregnant participants in the third-trimester (n = 118) to study continuously worn smart ring devices monitoring heart rate, heart rate variability, skin temperature, sleep and physical activity from negative temperature coefficient, 3-D accelerometer and infrared photoplethysmography sensors. Weekly surveys assessed labor symptoms, pain, fatigue and mood. We estimated the association between each metric, gestational age, and the likelihood of a participant's labor beginning prior to (versus after) the clinical estimated delivery date (EDD) of 40.0 weeks with mixed effects regression. A boosted random forest was trained on the physiological metrics to predict pregnancies that naturally passed the EDD versus undergoing onset of labor prior to the EDD. Here we report that many raw sleep, activity, pain, fatigue and labor symptom metrics are correlated with gestational age. As gestational age advances, pregnant individuals have lower resting heart rate 0.357 beats/minute/week, 0.84 higher heart rate variability (milliseconds) and shorter durations of physical activity and sleep. Further, random forest predictions determine pregnancies that would pass the EDD with accuracy of 0.71 (area under the receiver operating curve). Self-reported symptoms of labor correlate with increased gestational age and not with the timing of labor (relative to EDD) or onset of spontaneous labor. The use of maternal smart ring-derived physiological data in the third-trimester may improve prediction of the natural duration of pregnancy relative to the EDD.
Economic Effects of Medicaid Expansion in Michigan
Authors: John Z. Ayanian, Gabriel M. Ehrlich, Donald R. Grimes, Helen Levy
Journal: New England Journal of Medicine (2017)

Interview with Dr. John Ayanian on the economic benefits associated with Michigan's decision to expand Medicaid. (06:35)Download Analysis of effects in Michigan confirms that federal funding for Medicaid expansion offers states a fiscal benefit through reduced state spending on Medicaid-covered services and a macroeconomic benefit through increased economic activity and redirected personal spending.
Re: Jean-Nicolas Cornu, Paul Zantek, Glyn Burtt, et al. Minimally Invasive Treatments for Benign Prostatic Obstruction: A Systematic Review and Network Meta-analysis. Eur Urol 2023;83:534–47
Authors: Paolo Capogrosso, Federico Dehò, Andrea Salonia, Alberto Briganti, Francesco Montorsi
Journal: European Urology (2023)
Immunostimulatory gene therapy combined with checkpoint blockade reshapes tumor microenvironment and enhances ovarian cancer immunotherapy
Authors: Yunzhu Lin, Xiang Wang, Shi He, Zhongxin Duan, Yunchu Zhang, Xiaodong Sun, Yuzhu Hu, Yuanyuan Zhang, Zhiyong Qian, Xiang Gao, Zhirong Zhang
Journal: Acta Pharmaceutica Sinica B (2023)

Immune evasion has made ovarian cancer notorious for its refractory features, making the development of immunotherapy highly appealing to ovarian cancer treatment. The immune-stimulating cytokine IL-12 exhibits excellent antitumor activities. However, IL-12 can induce IFN-
Longitudinal risk factors for obstructive sleep apnea: A systematic review
Authors: Yaoyao Qian, Shyamali C. Dharmage, Garun S. Hamilton, Caroline J. Lodge, Adrian J. Lowe, Jingwen Zhang, Gayan Bowatte, Jennifer L. Perret, Chamara V. Senaratna
Journal: Sleep Medicine Reviews (2023)

Despite substantial disease burden, existing evidence on the risk factors for obstructive sleep apnea (OSA) have been derived primarily from cross-sectional studies without determining temporality. Therefore, we aimed to systematically synthesize the literature on longitudinal risk factors for sleep study-assessed OSA and questionnaire-assessed probable OSA from cohort studies in the general adult population settings. We systematically searched Embase and Medline (on OVID) databases. Eleven studies met the inclusion criteria. Meta-analyses were not conducted due to methodological heterogeneity of exposure and outcome measurements. There was consistent evidence that weight gain was associated with incident (n = 2) and greater severity (n = 2) of OSA. One study each observed an association of higher baseline body-mass index, male sex, asthma, a specific genetic polymorphism in rs12415421, and insulin resistance/hyperglycemia, with incident OSA. Long-term exposure to ambient air pollution (NO2, n = 1) was associated with OSA, and menopausal transitions (n = 1) with higher apnea-hypopnea index. There were no eligible studies on long-term smoking or alcohol use. In conclusion, approximately 10% increase in weight, especially in males, might alert clinicians to consider potential or worsening OSA. Large, well-designed longitudinal studies are needed to consolidate knowledge on other associations with OSA development, especially on potentially modifiable risk factors.
Depicting the landscape of gut microbial-metabolic interaction and microbial-host immune heterogeneity in deficient and proficient DNA mismatch repair colorectal cancers
Authors: Jinming Li, Yangyang Guo, Jianqiang Liu, Fanying Guo, Lutao Du, Yongzhi Yang, Xinxiang Li, Yanlei Ma
Journal: Journal for ImmunoTherapy of Cancer (2023)

Background Accumulating evidence has indicated the role of gut microbiota in remodeling host immune signatures, but various interplays underlying colorectal cancers (CRC) with deficient DNA mismatch repair (dMMR) and proficient DNA mismatch repair (pMMR) remain poorly understood. This study aims to decipher the gut microbiome-host immune interactions between dMMR and pMMR CRC. Method We performed metagenomic sequencing and metabolomic analysis of fecal samples from a cohort encompassing 455 participants, including 21 dMMR CRC, 207 pMMR CRC, and 227 healthy controls. Among them, 50 tumor samples collected from 5 dMMR CRC and 45 pMMR CRC were conducted bulk RNA sequencing. Results Pronounced microbiota and metabolic heterogeneity were identified with 211 dMMR-enriched species, such as Fusobacterium nucleatum and Akkermansia muciniphila , 2 dMMR-depleted species, such as Flavonifractor plautii , 13 dMMR-enriched metabolites, such as retinoic acid, and 77 dMMR-depleted metabolites, such as lactic acid, succinic acid, and 2,3-dihydroxyvaleric acid. F. plautii was enriched in pMMR CRC and it was positively associated with fatty acid degradation, which might account for the accumulation of dMMR-depleted metabolites classified as short chain organic acid (lactic acid, succinic acid, and 2,3-dihydroxyvaleric acid) in pMMR CRC. The microbial-metabolic association analysis revealed the characterization of pMMR CRC as the accumulation of lactate induced by the depletion of specific gut microbiota which was negatively associated with antitumor immune, whereas the nucleotide metabolism and peptide degradation mediated by dMMR-enriched species characterized dMMR CRC. MMR-specific metabolic landscapes were related to distinctive immune features, such as CD8 + T cells, dendritic cells and M2-like macrophages. Conclusions Our mutiomics results delineate a heterogeneous landscape of microbiome-host immune interactions within dMMR and pMMR CRC from aspects of bacterial communities, metabolic features, and correlation with immunocyte compartment, which infers the underlying mechanism of heterogeneous immune responses.
Low molecular weight heparin synergistically enhances the efficacy of adoptive and anti-PD-1-based immunotherapy by increasing lymphocyte infiltration in colorectal cancer
Authors: Yibo Quan, Jie He, Qi Zou, Liuxi Zhang, Qihui Sun, Hongli Huang, Wanglin Li, Keping Xie, Fang Wei
Journal: Journal for ImmunoTherapy of Cancer (2023)

Immunotherapy, including adoptive cell therapy (ACT) and immune checkpoint inhibitors (ICIs), has a limited effect in most patients with colorectal cancer (CRC), and the efficacy is further limited in patients with liver metastasis. Lack of antitumor lymphocyte infiltration could be a major cause, and there remains an urgent need for more potent and safer therapies for CRC.