AB0539 DEPRESSION, SELF-ESTEEM AND QUALITY OF LIFE IN SJÖGREN’S SYNDROME
Authors: T. Ramia, S. Daada, I. Chaabene, R. Klii, S. Hammami, K. Ines, M. Kechida
Journal: Annals of the Rheumatic Diseases (2022)

Background Sjögren’s syndrome (SS) is a connective tissue disease characterized by a triad of fatigue, pain and dryness. SS is a chronic condition with important repercussions on functioning and a source of significant suffering. Therefore, the assessment of depressive symptoms, self-esteem and quality of life (QOL) is important in the clinical and research context. Objectives We aimed to describe the clinical picture, depression, QOL and self-esteem of patients followed for SS and to study their association with disease activity. Methods This is a descriptive and analytical cross-sectional study including 42 patients with SS diagnosed based on the criteria of the American European Consensus Group of 2002 (AECG). Depression was evaluated by the Beck 13 scale, QOL by the SF-36 and self- esteem by the Rosenberg scale. Disease activity was assessed by EULAR Sjörgen Syndrome Disease Activity Index (ESSDAI). Results The average age was 54.5 ±15.67 years and the sex ratio was 0.2. Assessment of disease activity of these patients showed an average activity score of 8.23 ±6.39 with low activity in 16 patients (38.1%), moderate activity in 18 patients (42.9%) and severe activity in 8 patients (19%). The QOL measured by SF-36 was impaired in all areas with averages ranging from 39.76 for physical limit to 66.28 for emotional limit. Depression score evaluated by the Beck scale was 8.42 ±7.05on average with 59.5% of the patients having depression. The self-esteem score evaluated by Rosenberg scale was 32.8 ± 5.7on average. Self-esteem was rated as low to very low in 30.95% of patients. Disease activity score was correlated to Beck’s depression score (r= 0.545; p= 0.001); and Rosenberg’s self-esteem score (r= -0.51; p= 0.001). Likewise, we found a correlation between the SF-36 score and Beck’s depression score; the SF-36 score and Rosenberg’s self-esteem score (p&lt; 0.05). Conclusion As QOL, self esteem and depression were correlated to disease activity, taking into account these aspects in SS can improve the overall management of the disease. References [1]Milin M, Cornec D, Chastaing M, Griner V, Berrouiguet S, Nowak E, et al. Sicca symptoms are associated with similar fatigue, anxiety, depression, and quality-of-life impairments in patients with and without primary Sjögren’s syndrome. Joint Bone Spine. déc 2016;83(6):681‑5. [2]Rajagopalan K, Abetz L, Mertzanis P, Espindle D, Begley C, Chalmers R, et al. Comparing the discriminative validity of two generic and one disease-specific health-related quality of life measures in a sample of patients with dry eye. Value Health J Int Soc Pharmacoeconomics Outcomes Res. avr 2005;8(2):168‑74. [3]Shen C-C, Yang AC, Kuo BI-T, Tsai S-J. Risk of Psychiatric Disorders Following Primary Sjögren Syndrome: A Nationwide Population-based Retrospective Cohort Study. J Rheumatol. juill 2015;42(7):1203‑8. [4]Stevenson HA, Jones ME, Rostron JL, Longman LP, Field EA. UK patients with primary Sjögren’s syndrome are at increased risk from clinical depression. Gerodontology. sept 2004;21(3):141‑5. [5]Kang J-H, Lin H-C. Comorbidities in patients with primary Sjogren’s syndrome: a registry-based case-control study. J Rheumatol. Juin 2010;37(6):1188‑94. Page 88 [6]Cui Y, Li L, Yin R, Zhao Q, Chen S, Zhang Q, et al. Depression in primary Sjögren’s syndrome: a systematic review and meta-analysis. Psychol Health Med. févr 2018;23(2):198‑209. [7]Bax HI, Vriesendorp TM, Kallenberg CGM, Kalk WWI. Fatigue and immune activity in Sjögren’s syndrome. Ann Rheum Dis. mars 2002;61(3):284. [8]Cui Y, Xia L, Li L, Zhao Q, Chen S, Gu Z. Anxiety and depression in primary Sjögren’s syndrome: a cross-sectional study. BMC Psychiatry. 16 2018;18(1):131. Disclosure of Interests None declared