tbuckley/cabot-search huggingface dataset:
Long COVID and the cardiovascular system—elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases
Authors: Mariann Gyöngyösi, Pilar Alcaide, Folkert W Asselbergs, Bianca J J M Brundel, Giovanni G Camici, Paula da Costa Martins, Péter Ferdinandy, Marianna Fontana, Henrique Girao, Massimiliano Gnecchi, Can Gollmann-Tepeköylü, Petra Kleinbongard, Thomas Krieg, Rosalinda Madonna, Melanie Paillard, Antonis Pantazis, Cinzia Perrino, Maurizio Pesce, Gabriele G Schiattarella, Joost P G Sluijter, Sabine Steffens, Carsten Tschöpe, Sophie Van Linthout, Sean M Davidson
Journal: Cardiovascular Research (2022)

Abstract Long COVID has become a world-wide, non-communicable epidemic, caused by long-lasting multiorgan symptoms that endure for weeks or months after SARS-CoV-2 infection has already subsided. This scientific document aims to provide insight into the possible causes and therapeutic options available for the cardiovascular manifestations of long COVID. In addition to chronic fatigue, which is a common symptom of long COVID, patients may present with chest pain, ECG abnormalities, postural orthostatic tachycardia, or newly developed supraventricular or ventricular arrhythmias. Imaging of the heart and vessels has provided evidence of chronic, post-infectious perimyocarditis with consequent left or right ventricular failure, arterial wall inflammation, or microthrombosis in certain patient populations. Better understanding of the underlying cellular and molecular mechanisms of long COVID will aid in the development of effective treatment strategies for its cardiovascular manifestations. A number of mechanisms have been proposed, including those involving direct effects on the myocardium, microthrombotic damage to vessels or endothelium, or persistent inflammation. Unfortunately, existing circulating biomarkers, coagulation, and inflammatory markers, are not highly predictive for either the presence or outcome of long COVID when measured 3 months after SARS-CoV-2 infection. Further studies are needed to understand underlying mechanisms, identify specific biomarkers, and guide future preventive strategies or treatments to address long COVID and its cardiovascular sequelae.
Global prevalence of depression and anxiety in patients with hepatocellular carcinoma: Systematic review and meta-analysis
Authors: Darren Jun Hao Tan, Sabrina Xin Zi Quek, Jie Ning Yong, Adithya Suresh, Kaiser Xuan Ming Koh, Wen Hui Lim, Jingxuan Quek, Ansel Tang, Caitlyn Tan, Benjamin Nah, Eunice Tan, Taisei Keitoku, Mark D Muthiah, Nicholas Syn, Cheng Han Ng, Beom Kyung Kim, Nobuharu Tamaki, Cyrus Su Hui Ho, Rohit Loomba, Daniel Q Huang
Journal: Clinical and Molecular Hepatology (2022)

Depression and anxiety are associated with poorer outcomes in patients with hepatocellular carcinoma (HCC). However, the prevalence of depression and anxiety in HCC are unclear. We aimed to establish the prevalence of depression and anxiety in patients with HCC.
A functional connectome signature of blood pressure in &amp;gt;30 000 participants from the UK biobank
Authors: Rongtao Jiang, Vince D Calhoun, Stephanie Noble, Jing Sui, Qinghao Liang, Shile Qi, Dustin Scheinost
Journal: Cardiovascular Research (2022)

Abstract Aims Elevated blood pressure (BP) is a prevalent modifiable risk factor for cardiovascular diseases and contributes to cognitive decline in late life. Despite the fact that functional changes may precede irreversible structural damage and emerge in an ongoing manner, studies have been predominantly informed by brain structure and group-level inferences. Here, we aim to delineate neurobiological correlates of BP at an individual level using machine learning and functional connectivity. Methods and results Based on whole-brain functional connectivity from the UK Biobank, we built a machine learning model to identify neural representations for individuals’ past (∼8.9 years before scanning, N = 35 882), current (N = 31 367), and future (∼2.4 years follow-up, N = 3 138) BP levels within a repeated cross-validation framework. We examined the impact of multiple potential covariates, as well as assessed these models’ generalizability across various contexts. The predictive models achieved significant correlations between predicted and actual systolic/diastolic BP and pulse pressure while controlling for multiple confounders. Predictions for participants not on antihypertensive medication were more accurate than for currently medicated patients. Moreover, the models demonstrated robust generalizability across contexts in terms of ethnicities, imaging centres, medication status, participant visits, gender, age, and body mass index. The identified connectivity patterns primarily involved the cerebellum, prefrontal, anterior insula, anterior cingulate cortex, supramarginal gyrus, and precuneus, which are key regions of the central autonomic network, and involved in cognition processing and susceptible to neurodegeneration in Alzheimer’s disease. Results also showed more involvement of default mode and frontoparietal networks in predicting future BP levels and in medicated participants. Conclusion This study, based on the largest neuroimaging sample currently available and using machine learning, identifies brain signatures underlying BP, providing evidence for meaningful BP-associated neural representations in connectivity profiles.
Outbreak control management: Lessons from SARS‐CoV‐2 infections in 2020–2022 in Hong Kong, an international municipality with high‐frequency travelers
Authors: Yaxiu Feng, Ching Han Young, Siu Hin Lau, Ming‐Liang He
Journal: MedComm (2022)

The control management of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is one of the most challenges in the 21st century. By May 8th, 2022, SARS-CoV-2 has infected over 510 million people with 6.2 million death worldwide and over 1.2 million people with 9133 deaths in the fifth wave of infection in Hong Kong. The government responded rapidly in the early days of the 2020 outbreak, and the results were encouraging to control COVID-19 outbreak unavailable of vaccine. The quick responses to the epidemic alerts, for example, public education and control policies, kept residents safe from infection in the city with such a high population density and large-scale travelers. Nevertheless, the extremely high infectivity, Omicron variant infections, and the shortcomings of transmission control measures led to uncontrollable outbreak in 2022. The weak immunity groups, elderly and children, experienced a high hospitalization rate and mortality rate because of low vaccination rate. Currently, the infection is under well controlled. This study timely summarizes the challenges, policy, and lessons of SARS-CoV-2 outbreak control from 2020 to 2022. More importantly, the lesson and policy revealed from this study may be beneficial and applied to other cities with the outbreak of highly infectious SARS-CoV-2.
Long-Term Leisure-Time Physical Activity Intensity and All-Cause and Cause-Specific Mortality: A Prospective Cohort of US Adults
Authors: Dong Hoon Lee, Leandro F.M. Rezende, Hee-Kyung Joh, NaNa Keum, Gerson Ferrari, Juan Pablo Rey-Lopez, Eric B. Rimm, Fred K. Tabung, Edward L. Giovannucci
Journal: Circulation (2022)

The 2018 physical activity guidelines for Americans recommend a minimum of 150 to 300 min/wk of moderate physical activity (MPA), 75 to 150 min/wk of vigorous physical activity (VPA), or an equivalent combination of both. However, it remains unclear whether higher levels of long-term VPA and MPA are, independently and jointly, associated with lower mortality.A total of 116 221 adults from 2 large prospective US cohorts (Nurses' Health Study and Health Professionals Follow-up Study, 1988-2018) were analyzed. Detailed self-reported leisure-time physical activity was assessed with a validated questionnaire, repeated up to 15 times during the follow-up. Cox regression was used to estimate the hazard ratio and 95% CI of the association between long-term leisure-time physical activity intensity and all-cause and cause-specific mortality.During 30 years of follow-up, we identified 47 596 deaths. In analyses mutually adjusted for MPA and VPA, hazard ratios comparing individuals meeting the long-term leisure-time VPA guideline (75-149 min/wk) versus no VPA were 0.81 (95% CI, 0.76-0.87) for all-cause mortality, 0.69 (95% CI, 0.60-0.78) for cardiovascular disease (CVD) mortality, and 0.85 (95% CI, 0.79-0.92) for non-CVD mortality. Meeting the long-term leisure-time MPA guideline (150-299 min/wk) was similarly associated with lower mortality: 19% to 25% lower risk of all-cause, CVD, and non-CVD mortality. Compared with those meeting the long-term leisure-time physical activity guidelines, participants who reported 2 to 4 times above the recommended minimum of long-term leisure-time VPA (150-299 min/wk) or MPA (300-599 min/wk) showed 2% to 4% and 3% to 13% lower mortality, respectively. Higher levels of either long-term leisure-time VPA (≥300 min/wk) or MPA (≥600 min/wk) did not clearly show further lower all-cause, CVD, and non-CVD mortality or harm. In joint analyses, for individuals who reported <300 min/wk of long-term leisure-time MPA, additional leisure-time VPA was associated with lower mortality; however, among those who reported ≥300 min/wk of long-term leisure-time MPA, additional leisure-time VPA did not appear to be associated with lower mortality beyond MPA.The nearly maximum association with lower mortality was achieved by performing ≈150 to 300 min/wk of long-term leisure-time VPA, 300 to 600 min/wk of long-term leisure-time MPA, or an equivalent combination of both.
The “staying alive” theory reinforces stereotypes and shows women's lower quality of life
Authors: Konrad Szocik
Journal: Behavioral and Brain Sciences (2022)

Abstract Staying alive theory explains why women have more effective self-protective mechanisms in terms of woman's role as a mother and caregiver. This theory reinforces stereotypes and the relationship of oppression and submission to men. Somewhat paradoxically, it also points to women's lower quality of life, which may be explained by their greater fear of threats caused by men's power.
Women need to stay alive and protect reproductive choice
Authors: Melissa M. McDonald, Rachel M. James
Journal: Behavioral and Brain Sciences (2022)

Abstract Defense of reproductive choice is an important motivation in women's self-protection psychology for which the “staying alive theory” cannot fully account. Evidence indicates that some elements of women's self-protection psychology function to protect reproductive choice rather than survival, or may be equally well explained by either motivation. Integrating perspectives will result in greater explanatory breadth and precision in theory testing.
“Staying alive” in the context of intimate partner abuse
Authors: Courtney Humeny
Journal: Behavioral and Brain Sciences (2022)

Abstract Females are disproportionately affected by intimate partner abuse that can result in severe physical and mental harm. Benenson et al. provide little exploration of how female-evolved traits enhance females' survival in abusive relationships. Discussion centres on “why” females do not “just leave” an abusive relationship and the effectiveness of female-evolved traits in navigating intimate partner abuse over time.
Psychological and behavioral implications of self-protection and self-enhancement
Authors: Dianne M Tice, Roy F Baumeister, Constantine Sedikides
Journal: Behavioral and Brain Sciences (2022)

Self-protection can have psychological and behavioral implications. We contrast them with the implications of a self-enhancement strategy. Both self-enhancement and self-protection have costs and benefits as survival strategies, and we identify some of the emotional, cognitive, and behavioral tradeoffs associated with the differential preferences for each strategy. New analyses on a large existing data set confirm the target article's hypothesis that women are more attuned than men to potential negative consequences of innovations.
Beyond individual sex differences: “Staying alive theory” as an adaptive complex
Authors: John Archer
Journal: Behavioral and Brain Sciences (2022)

Abstract Extended staying alive theory (SAT) raises the issue of the extent to which its various attributes are linked or whether they provide alternative means to the same adaptive ends. Theories such as SAT that consider an array of sex differences may benefit from the application of the multivariate D statistic, rather than using a series of d values, as is common at present.
Sex-dependent selection, ageing, and implications for “staying alive”
Authors: Robert C. Brooks, Khandis R. Blake
Journal: Behavioral and Brain Sciences (2022)

Abstract Incorporating theoretic insights from ageing biology could advance the “staying alive” hypothesis. Higher male extrinsic mortality can weaken selection against ageing-related diseases and self-preservation, leading to high male intrinsic mortality. This may incidentally result in female-biased longevity-promoting traits, a possibility that will require rigorous testing in order to disentangle from the adaptive self-preservation hypothesis presented in the target article.
An expanded “staying alive” theory (SAT) underplays complexity in <i>Homo sapiens</i>
Authors: Agustín Fuentes
Journal: Behavioral and Brain Sciences (2022)

Abstract The target article takes myriad human female patterns and aligns them as a unit emerging from an expanded version of “staying alive” theory (SAT). Females and males do differ, however, to treat the complexity of human response to threats as an explicit, evolved sexually dimorphic package is not reflective of current knowledge regarding health, sex/gender, and behavior in Homo sapiens .
Women take risks to help others to stay alive
Authors: Alice H. Eagly
Journal: Behavioral and Brain Sciences (2022)

Abstract Evidence that women voluntarily expose themselves to some threats more than men do challenges the generalizability of the claim that women exceed men in self-protective responses. Examples include women's higher rates of living organ donation and rescuing Jews during the holocaust. In general, women's efforts to keep other people alive can take precedence over their efforts to protect themselves.
Staying alive includes adaptations for catalyzing cooperation
Authors: Alessandra Cassar
Journal: Behavioral and Brain Sciences (2022)

Abstract The target article interprets women's lower competitiveness than men's as evidence of adaptation to help women avoid physical conflicts and stay alive. This commentary advances the additional hypothesis that strategically suppressing competitiveness, thus signaling egalitarian intentions, could be an adaptation to catalyze cooperative behavior from males and females, turning natural competitors (other women) into allies and men into supportive partners.
Staying alive enhances both women's and men's fitness
Authors: Renée V. Hagen, Delaney A. Knorr, Sally Li, Ashley Mensing, Brooke A. Scelza
Journal: Behavioral and Brain Sciences (2022)

Abstract We argue that Benenson et al. need to consider not only sex differences in the effects of care on offspring survival but also in age-specific fertility when predicting how longevity affects fitness. We review evidence that staying alive has important effects on both women's and men's fitness, and encourage consideration of alternative explanations for observed sex differences in threat responses.
Women amid the COVID-19 pandemic: Self-protection through the behavioral immune system
Authors: Alfonso Troisi
Journal: Behavioral and Brain Sciences (2022)

Abstract Studies of the activation of the behavioral immune system triggered by the coronavirus disease-2019 pandemic have demonstrated that evolutionary explanations of individual differences in self-protection should not be based only on parental investment and sexual selection theory. An evolutionary model must also incorporate individual differences that arise within each sex as a result of life history strategies and attachment patterns.
The pregnancy compensation hypothesis, not the staying alive theory, accounts for disparate autoimmune functioning of women around the world
Authors: Erin M O'Mara Kunz, Jackson A Goodnight, Melissa A Wilson
Journal: Behavioral and Brain Sciences (2022)

Abstract The pregnancy compensation hypothesis provides a mechanistic explanation for the evolution of sex differences in immune system functioning, the excess of women experiencing autoimmune disease, and why this is observed only in industrialized nations; none of which can be explained by the staying alive theory, as proposed by the authors of the target article.
Somatic maintenance/reproduction tradeoffs and human evolution
Authors: Kristen Hawkes
Journal: Behavioral and Brain Sciences (2022)

Abstract The authors propose that many morbidities higher in women than men are adaptations protecting survival, selected because survival has been especially crucial to mothers' reproductive success. Following their lead, I pursue variation in tradeoffs between reproduction and survival recognized by Darwin that were likely central to the evolution of many traits that distinguish us from our great ape cousins.
Toward a more domain-specific conceptualization of female traits: A commentary on Benenson et al. (2022)
Authors: Courtney L. Crosby, Rebecka K. Hahnel-Peeters, David M. Buss
Journal: Behavioral and Brain Sciences (2022)

Abstract Benenson et al. (2022) amass impressive evidence of robust sex differences as support for expanding “staying alive” theory. We argue for a broader and more domain-specific conceptualization focusing on life history tradeoffs between survival and mating success. Using three examples – women's disgust, fear of rape, and cultivation of bodyguards – we illustrate these tradeoffs and suggest a broader theoretical framework.
Only as a last resort: Sociocultural differences between women and men explain women's heightened reaction to threat, not evolutionary principles
Authors: Jeffrey R. Huntsinger, Akila Raoul
Journal: Behavioral and Brain Sciences (2022)

The target article proposed that women display greater self-protectiveness than men to major physical and social threats because such self-protective responses have higher fitness value for women than men. Rather than having evolutionary roots, we suggest the various physiological, behavioral, and emotional responses to social and physical threats exhibited more by women than men are instead rooted in sociocultural forces.
Harm or protection? Two-sided consequences of females' susceptible responses to multiple threats
Authors: Jingyuan Lin, Pim Cuijpers, Hong Li, Yi Lei
Journal: Behavioral and Brain Sciences (2022)

Abstract The target article presented a plausible argument that females' susceptibility to threats might be self-protection for staying alive , but some evidence requires scrutiny. We need to consider (1) the biases of narrative reviews, (2) subjective life quality, and (3) the shadow side of extreme reactions to threats before concluding that females' threat-based response is a self-protection mechanism that promotes survival.
Societies also prioritize female survival
Authors: April Bleske-Rechek, Robert O. Deaner
Journal: Behavioral and Brain Sciences (2022)

Abstract We extend Benenson et al.'s hypothesis from the individual level to the societal level. Because women have highly limited reproductive rates, societies have generally prioritized female survival and regarded males as expendable. We describe various lines of evidence that are consistent with this hypothesis, and we offer additional predictions about differential attitudes toward male versus female endangerment.
Sex differences in longevity are relative, not independent
Authors: Mikkel Wallentin
Journal: Behavioral and Brain Sciences (2022)

Abstract I ask three questions related to the claims made within the staying alive theory (SAT): Is survival more fitness-enhancing for females than for males? Does the historical record on sex differences in mortality support the SAT? Is it possible to talk about “independent selective pressures on both male and female traits” when all we have are sex/gender comparisons?
Sex differences are insufficient evidence of ecological adaptations in human females
Authors: Toe Aung, Sojung Baek, David Puts
Journal: Behavioral and Brain Sciences (2022)

Abstract Benenson et al. postulate that human females evolved unique survival adaptations to facilitate maternal and grandmaternal care. This hypothesis is consistent with the broader hypothesis that female phenotypes are more ecologically optimal, but further evidence is needed to make a compelling case that sex differences in self-protection are not primarily the result of more intense sexual selection on males.
Biological sex, by-products, and other continuous variables
Authors: John G. Neuhoff
Journal: Behavioral and Brain Sciences (2022)

Sex/gender is a continuous variable that researchers frequently treat as dichotomous. This practice can mask continuous underlying adaptive traits and yield spurious dichotomous "sex differences." As such, many sex differences in self-protection may be evolutionary by-products of underlying adaptations rather than adaptations themselves. Binary analysis of continuous sex/gender is ill-considered science that can contribute to inequality and counterproductive public policy.
Female advantage in threat avoidance manifests in threat reaction but not threat detection
Authors: David S. March, Lowell Gaertner
Journal: Behavioral and Brain Sciences (2022)

Abstract Threat avoidance involves both detection of a threatening stimulus and reaction to it. We demonstrate with empirically validated stimuli (that are threatening, nonthreatening-negative, neutral, or positive) that threat detection is more pronounced among males, whereas threat reactivity is more pronounced among females. Why women are less efficient detectors of threat challenges Benenson et al.'s conceptual analysis.
Pathological complexity and the evolution of sex differences
Authors: Walter Veit, Heather Browning
Journal: Behavioral and Brain Sciences (2022)

Abstract Benenson et al. provide a compelling case for treating greater investment into self-protection among females as an adaptive strategy. Here, we wish to expand their proposed adaptive explanation by placing it squarely in modern state-based and behavioural life-history theory, drawing on Veit's pathological complexity framework. This allows us to make sense of alternative “lifestyle” strategies, rather than pathologizing them.
Females undergo selection too
Authors: Joyce F. Benenson, Christine E. Webb, Richard W. Wrangham
Journal: Behavioral and Brain Sciences (2022)

Abstract Extending Campbell's (1999) staying alive theory (SAT) beyond aggression, we reviewed evidence that females are more self-protective than males. Many commentators provided additional supporting data. Sex differences in life-history adaptations, in the optimal relation between survival and reproduction, and in the mechanisms underlying trade-offs involved with self-protection remain important topics with numerous opportunities for improved understanding.