tbuckley/cabot-search huggingface dataset:
A comparison of the effect of inducers on the expression of glutathione-S-transferases in the liver of the intact rat and in hepatocytes in primary culture
Authors: S Langouet
Journal: Hepatology (1996)

Recently, we used human hepatocytes in primary culture to study the effects of inducers of glutathione-S-transferases (GSTs) in the expectation that information obtained can be used to predict the value of particular inducers for use in the chemoprevention of cancer and other toxicities. However, in vitro human studies cannot readily be confirmed by studies in vivo. This problem does not arise in experimental animals. In the current studies, the response of male rat hepatocytes in primary culture to the following inducers of GST isoenzymes has been determined: 3-methylcholanthrene (MC); phenobarbital (PB); 1,2-dithiole-3-thione and its 5-(2-pyrazinyl)-4-methyl derivative, oltipraz (OPZ), and the results have been compared with induction obtained in livers of MC- and OPZ-treated rats. Each type of inducer was found to elicit a different response. In vitro, phenobarbital increased messenger RNA (mRNA) levels of subunits 1b and 3 after 12 and 72 hours, respectively; MC had a rapid effect on GST alpha class mRNAs (bringing about increase after only 2 hours of treatment), increased subunit 7 mRNA slightly, and had no effect on mu class mRNAs; dithiolethiones induced both subunit lb and 7 mRNAs after 4 hours and, to a much lower extent, subunit 3 mRNA after 72 hours. In vivo, MC induced significantly both subunit lb and 7 mRNAs whereas OPZ increased significantly subunits lb, 3 and 7 mRNA levels, and to a lower extent those of subunit 2, after 3 days and beyond to at least 5 days of treatment. Results obtained in mRNA studies were confirmed by high-pressure liquid chromatography (HPLC) analysis of GST subunits. HPLC also showed an induction of subunit 10 at the protein level of which the mRNA was not analyzed. Our results show that rat hepatocytes in primary culture prove to be a good model for the effect of inducers on both the expression of GST mRNA and protein levels in the rat liver in vivo. The demonstration of this good correlation in the rat with respect to increases gives support for the use of human hepatocytes for predictive studies of chemoprotection in human pharmacology.
Unexpected feedback
Authors: Jane Barrett
Journal: BMJ (2005)

transient tachypnoea of the newborn from 4% of elective caesarean sections to 2.1% and that of respiratory distress syndrome from 1.1% to 0.2%.To our knowledge this is the first report that antenatal steroids prevent transient tachypnoea.During labour and at birth, the mature lung switches from active chloride and fluid secretion to active sodium and fluid absorption. 15-17The reduced incidence of transient tachypnoea in the steroid group is consistent with the hypothesis that corticosteroids, increased in mother and fetus through the stress of labour, encourage the expression of the epithelial channel gene and allow the lung to switch from fluid secretion to fluid absorption.Without another source of corticosteroid, elective caesarean section will disrupt this process. ConclusionAntenatal betamethasone is effective in reducing admission to a special care baby unit with respiratory distress after elective caesarean section at term.In planning elec-tive caesareans, the risk of respiratory distress should be considered and the likely benefits of antenatal corticosteroids should be compared with those of delaying delivery until 39 weeks when possible.We thank all participants-patients, staff, and collaborators-for their contributions.
Laryngeal Trauma
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Open-heart surgery and the demand for blood
Authors: J. K. Roche
Journal: JAMA (1973)

Data from 88% of United States institutions that perform cardiopulmonary bypass surgery were analyzed to determine the type, time of storage, anticoagulant, and amount of blood used. The frequency with which cardiopulmonary bypass procedures are performed has more than doubled in the last five years, demanding an ever increasing proportion of the national blood resource. An average of nearly eight units of blood were used per case in 1971. Problems in procurement continue, as a marked number of surgical teams still require fresh, heparinized blood in relatively large amounts. Since the increasing use of saphenous vein bypass surgery may create a prodigious demand upon the blood resource of this country, new policies and practices are needed to reduce the amount of exogenous whole blood used per patient.
Benchmark Concentrations for Methylmercury Obtained from the Seychelles Child Development Study
Authors: Kenny S. Crump, Cynthia Van Landingham, Conrad Shamlaye, Christopher Cox, Phillip W. Davidson, Gary J. Myers, Thomas W. Clarkson
Journal: Environmental Health Perspectives (2000)

Methylmercury is a neurotoxin at high exposures, and the developing fetus is particularly susceptible. Because exposure to methylmercury is primarily through fish, concern has been expressed that the consumption of fish by pregnant women could adversely affect their fetuses. The reference dose for methylmercury established by the U.S. Environmental Protection Agency was based on a benchmark analysis of data from a poisoning episode in Iraq in which mothers consumed seed grain treated with methylmercury during pregnancy. However, exposures in this study were short term and at much higher levels than those that result from fish consumption. In contrast, the Agency for Toxic Substances and Disease Registry (ATSDR) based its proposed minimal risk level on a no-observed-adverse-effect level (NOAEL) derived from neurologic testing of children in the Seychelles Islands, where fish is an important dietary staple. Because no adverse effects from mercury were seen in the Seychelles study, the ATSDR considered the mean exposure in the study to be a NOAEL. However, a mean exposure may not be a good indicator of a no-effect exposure level. To provide an alternative basis for deriving an appropriate human exposure level from the Seychelles study, we conducted a benchmark analysis on these data. Our analysis included responses from batteries of neurologic tests applied to children at 6, 19, 29, and 66 months of age. We also analyzed developmental milestones (age first walked and first talked). We explored a number of dose-response models, sets of covariates to include in the models, and definitions of background response. Our analysis also involved modeling responses expressed as both continuous and quantal data. The most reliable analyses were considered to be represented by 144 calculated lower statistical bounds on the benchmark dose (BMDLs; the lower statistical bound on maternal mercury hair level corresponding to an increase of 0.1 in the probability of an adverse response) derived from the modeling of continuous responses. The average value of the BMDL in these 144 analyses was 25 ppm mercury in maternal hair, with a range of 19 to 30 ppm.
The Power of Silence
Authors: Bruce P. Himelstein, Nancy L. Jackson, Linda Pegram
Journal: Journal of Clinical Oncology (2001)

Article Tools THE ART OF ONCOLOGY: WHEN THE TUMOR IS NOT THE TARGET Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2001.19.19.3996 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11579123 The Power of Silence Bruce P. HimelsteinxBruce P. HimelsteinSearch for articles by this author , Nancy L. JacksonxNancy L. JacksonSearch for articles by this author , Linda PegramxLinda PegramSearch for articles by this author Show More From the Palliative Care Service, The Children’s Hospital of Philadelphia, Philadelphia, PA. https://doi.org/10.1200/JCO.2001.19.19.3996 Full Text PDF Figures and Tables "The Power of Silence." Journal of Clinical Oncology, 19(19), p. 3996© 2001 by American Society of Clinical Oncology
Heberden Society: JOINT MEETING WITH THE NEDERLANDS VERENIGING VAN RHEUMATOLOGEN Groningen, May 17, 1963
Journal: Annals of the Rheumatic Diseases (1963)

Kugelmass, is "charged with the nisus elan of chemical wisdom, supreme in choice of international authors, optimal in standards of chemical scholarship, provocative in imagination for experimental research, comprehensive in discussion of scientific medicine, and authoritative in chemical perspective of human disorders".Of course, nobody expects a preface to be taken seriously, but any reader who is obsessive enough to look at this preface and who might get the idea that he is about to be sold the elixir of life, can be reassured that the book is no more than (and no less than) a sequence of brief, useful, and well-balanced reviews, along orthodox lines, under the chapter headings Biochemistry of Connective Tissue, Biochemistry of Rheumatoid Arthritis, Systemic Lupus, Periarteritis Nodosa, Dermatomyositis, and Diffuse Scleroderma.Students and others seeking up-to-date introduction to these subjects will find these chapters helpful, although less comprehensive than accounts of similar topics in standard texts.The last
Incidence and risk factors for cardiovascular events in patients with advanced fibrosis due to non-alcoholic steatohepatitis: data from the phase 3 STELLAR trials
Authors: Mazen Noureddin, Jörn M. Schattenberg, Javier Crespo, Masayuki Kurosaki, Chi-Yi Chen, Vincent Leroy, Manal Abdelmalek, Won Young Tak, Jacob George, Arun Shankar, Dora Ding, Marianne Camargo, Kathryn Kersey, Robert Myers, Stephen Harrison, Manuel Romero Gomez, Shiv Kumar Sarin, Zobair M. Younossi, Mary Rinella, Kathleen Corey
Journal: Journal of Hepatology (2020)
The Letter
Authors: Lauren Pischel
Journal: Annals of Internal Medicine (2018)

On Being a Doctor17 July 2018The LetterLauren Pischel, MDLauren Pischel, MDYale Internal Medicine, New Haven, Connecticut (L.P.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M18-0627 Audio Reading - “The Letter” Audio. Virginia L. Hood, MD, reads "The Letter," by L. Pischel. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail It took a month for the letter to find me and a month and a half for me to open it. Mr. M wrote it the day after she died and addressed it to the main hospital. After three crossed-off addresses and one large “Internal Medicine” in red ink, someone who bureaucratically knew me found it and was kind enough to alert me via a nondescript e-mail. I picked the letter up, saw the shaky blue print and same last name, and thought back to Mrs. M.I met her on my second day in the intensive care unit. She ... Author, Article, and Disclosure InformationAffiliations: Yale Internal Medicine, New Haven, Connecticut (L.P.)Corresponding Author: Lauren Pischel, MD, Yale Internal Medicine Residency Program, 20 York Street, PO Box 208030, New Haven, CT 06520; e-mail, lauren.[email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “The Letter” Audio. Virginia L. Hood, MD, reads "The Letter," by L. Pischel. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 17 July 2018Volume 169, Issue 2Page: 126KeywordsComputersConsciousnessEmotionsHeartHypotensionIntensive care unitsLiverLungsResidencyThorax ePublished: 17 July 2018 Issue Published: 17 July 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Community-Based HIV Prevention in Presumably Underserved Populations—July-September 1995
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Provision of Prescription Drug Info Mandated
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OBSTRUCTION OF THE HEPATIC VEINS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PREVENTIVE MEDICINE AND STATISTICS OF DISEASE IN VERMONT.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An observational prospective study on central venous devices (CVD) use in oncologic patients: Registro CVD - PoloNord
Authors: G. Aondio, D. Fagnani, C. Porta, R. Franchi, M. Fiumanò, M. Giordano, A. Bertolini, A. Ardizzoia, C. Cimminiello
Journal: Journal of Clinical Oncology (2004)

8239 Background: the use of CVD is continuously increasing in oncologic patients due to a number of advantages in terms of quality of life and safety. However several questions remain still unresolved including the true rate of complications related to these devices. To better clarify the issue we planned an observational prospective study on CVD use, called "Registro CVD - PoloNord", collecting all patients (pts) having placed a CVD, in the PoloNord Group Oncology Services. Methods: starting from January 2003, 19 centers participated to the survey with the aim to follow-up their patients, every four month, for a total of three years. All pts data were collected in a computer-assisted log, running into a web server technology. CVD model, patient medical history and relationships with drug therapy including antithrombotic prophylaxis, CVD related adverse events, thromboembolic events and patient outcome were recorded. Results: so far 504 pts were recruited, the majority of them having advanced disease. There were 250 pts followed-up for at least the first four months; of them 105 (42%) were given an antithrombotic prophylaxis which was represented mainly by low-dose warfarin. We observed 29 (11%) CVD-related complications: 4 misplacements, 6 infections, 5 catheter ruptures, 3 disconnections, 1 occlusion, 9 catheter thrombosis, 1 thoracic decubitus. Furthermore we noticed 23 (9%) thromboembolic events: 2 pulmonary embolisms, 16 deep venous thrombosis and 5 superficial thromboflebitis. The mean follow-up period was 8.5 months. The median time to the first occurring CVD-related complication and thromboembolic event was 185 and 40 days respectively . Conclusions: there is still uncertainty on the need of antithrombotic prophylaxis in pts with a CVD, because of the conflicting data existing on the true rate of thromboembolic complications. By means of survey and registers such as our study we hope to better understand this issue on the basis of clinical practice-based observation. No significant financial relationships to disclose.
ENZYMATIC ACTIVITY OF THE ISOLATED GLOMERULUS IN NORMAL AND NEPHROTIC RATS
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Popliteal mycotic aneurysm presenting as septic arthritis and purpura
Authors: M. Merry
Journal: JAMA (1972)

A 44-year-old man, previously in excellent health, developed a mycotic aneurysm of his popliteal artery. Classic signs of arterial wall sepsis were preceded by septic arthritis in the great toe and knee joint on the affected side and diffuse purpura in the skin. The aneurysm was successfully resected and good arterial blood supply in the leg obtained by an autologous vein graft. We believe this is the first description of septic arthritis or purpura as presenting signs of a peripheral mycotic aneurysm.
Medicine, Literature and Eponyms: An Encyclopedia of Medical Eponyms Derived From Literary Characters
Authors: John H. Dirckx
Journal: JAMA (1990)

The physician who sets out to impress his colleagues and the world by inventing a new medical term that flaunts his knowledge of belles lettres runs the risk of merely revealing his ignorance and naïveté and provoking ridicule. Rodin and Key's<i>Medicine, Literature and Eponyms</i>clearly illustrates that proposition. Of more than 350 literary eponyms and allusions cataloged here, barely a dozen seem fully apt. Nearly half of the terms defined pertain to psychiatry, most of them apparently coined in imitation of Freud's whimsical and farfetched<i>Oedipus complex</i>. The compilers began collecting medical terms referring to literary characters with the intention of writing a paper but amassed so much material that they had to write an encyclopedia instead. The result is a ragbag of literary lore drawn from myth, legend, Scripture, and modern fiction and drama. Some might object that<i>gargoylism, happy puppet syndrome</i>, and<i>old sergeant syndrome</i>have no