tbuckley/cabot-search huggingface dataset:
Iconographia Boerhaavii
Authors: Lester S. King
Journal: JAMA (1964)

To secure a well-rounded picture of a great man we may study his works, which will reveal a great deal about his personality. Then, too, biographical data will contribute to the total picture. But a knowledge of his outward appearance and a study of his physiognomy are invaluable. So in the introduction declares Dr. Lindeboom, leading authority on Boerhaave, who has devoted so much careful scholarship to furthering our knowledge of the great Dutch physician. Lindeboom has collected literary descriptions of Boerhaave's personal appearance together with all available portraits, as well as drawings, engravings, and other art works which depict him. The most important items are reproduced in 40 excellent halftone plates, and there is a brief but informative text. Altogether this is a splendid contribution to the medical iconography of a great physician.
Ueber die pathologische Anatomie der Spirochaetosis icterohaemorrhagica Inada. (Weilsche Krankheit).
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Slow intestinal transit: A motor disorder contributing to cholesterol gallstone formation in the ground squirrel
Authors: Q Xu
Journal: Hepatology (1996)

Impaired gallbladder motility is an established factor in cholesterol gallstone formation. We assessed whether altered small intestinal smooth muscle contractility with slow transit might potentiate gallstone formation by further impeding enterohepatic cycling of bile acids. Ground squirrels were fed a 1% or a trace (controls) cholesterol diet. Small intestinal transit was evaluated from 51Cr distribution in conscious, fasted animals 20 minutes after infusion into the proximal jejunum. Small intestinal and gallbladder smooth muscle contractility was determined in vitro. Biliary lipid secretion was measured from the cannulated common duct and the bile salt pool size calculated by isotope dilution. Gas-liquid chromatography (GLC) assessed bile salt profile. In animals on the 1% cholesterol diet, aboral transit was significantly delayed, the maximal contractile response to bethanechol was markedly increased (P <.05) with no change in median effective concentration in either circular or longitudinal muscle strips from both the jejunum and ileum, and the gallbladder contractile responses to bethanechol and cholecystokinin (CCK) were decreased. Cholesterol saturation index and the fraction of deoxycholic acid in the pool doubled, whereas the total bile salt pool size remained unchanged in cholesterol-fed animals. In this model, a high-cholesterol diet is associated with altered small intestinal smooth muscle contractility and prolonged small intestinal transit, in addition to diminished gallbladder contractility. The resulting sluggish enterohepatic cycling of bile salts, associated with expanded deoxycholate pool, contributes to cholesterol gallstone formation.
TEXTBOOK OF MEDICINE
Authors: L. J. Witts
Journal: BMJ (1956)

<h3>Background</h3> Rolandic epilepsy (RE) is the most common genetic childhood epilepsy, consisting of focal, nocturnal seizures and frequent neurodevelopmental impairments in speech, language, literacy and attention. A complex genetic aetiology is presumed in most, with monogenic mutations in <i>GRIN2A</i> accounting for &gt;5% of cases. <h3>Objective</h3> To identify rare, causal CNV in patients with RE. <h3>Methods</h3> We used high-density SNP arrays to analyse the presence of rare CNVs in 186 patients with RE from the UK, the USA, Sardinia, Argentina and Kerala, India. <h3>Results</h3> We identified 84 patients with one or more rare CNVs, and, within this group, 14 (7.5%) with recurrent risk factor CNVs and 15 (8.0%) with likely pathogenic CNVs. Nine patients carried recurrent hotspot CNVs including at 16p13.11 and 1p36, with the most striking finding that four individuals (three from Sardinia) carried a duplication, and one a deletion, at Xp22.31. Five patients with RE carried a rare CNV that disrupted genes associated with other epilepsies (<i>KCTD7</i>, <i>ARHGEF15</i>, <i>CACNA2D1, GRIN2A</i> and <i>ARHGEF4</i>), and 17 cases carried CNVs that disrupted genes associated with other neurological conditions or that are involved in neuronal signalling/development. Network analysis of disrupted genes with high brain expression identified significant enrichment in pathways of the cholinergic synapse, guanine-exchange factor activation and the mammalian target of rapamycin. <h3>Conclusion</h3> Our results provide a CNV profile of an ethnically diverse cohort of patients with RE, uncovering new areas of research focus, and emphasise the importance of studying non-western European populations in oligogenic disorders to uncover a full picture of risk variation.
Thyroid Carcinoma
Authors: DARCY L. KASNER, MICHAEL E. SPIETH, MARJORIE E. STARKMAN, DEBORAH ZDOR-NORTH
Journal: Clinical Nuclear Medicine (2002)

Purpose Reports state that scan results for as many as 25% of patients with differentiated thyroid carcinoma will convert to iodine-131 (I-131) negative over time with positive thyroglobulin levels. Tl-201, positron emission tomography (PET), and sestamibi or tetrofosmin have all helped to identify I-131–negative thyroid carcinomas. The authors have identified a case of reversal of I-131 findings from negative to positive after short-term thyroxine withdrawal combined with treatment with recombinant human thyroid-stimulating hormone (rhTSH). Materials and Methods The authors obtained multiple I-131 whole-body scans with 4-week thyroid hormone withdrawal, post–I-131 therapy scans, nonthyroid withdrawal Tl-201 chloride whole-body tumor images, and finally combined 2.5-week thyroid hormone withdrawal and rhTSH-stimulation I-131 whole-body scans before and after therapy. Results The authors examined one patient during a period of 9 years whose I-131 whole-body scan results were at first positive and then became negative. After a combination of rhTSH stimulation and thyroid hormone withdrawal, the results changed again to I-131 positive. Conclusions This is the first known case in which I-131 findings changed from negative to positive. A combination of rhTSH stimulation and nearly adequate withdrawal may help convert more I-131–negative whole-body scans to positive.
How should minimally important change scores for the Patient-Oriented Eczema Measure be interpreted? A validation using varied methods
Authors: L. Howells, S. Ratib, J.R. Chalmers, L. Bradshaw, K.S. Thomas
Journal: British Journal of Dermatology (2018)

Eczema is common, itchy skin condition. The Patient‐Oriented Eczema Measure (POEM) is a short questionnaire that patients or parents can fill out to tell us how severe their eczema symptoms (or those of their child) are. It provides a score from 0–28. In both research and clinical practice, we are often interested to see if these scores have improved over time. This study aimed to find out what change in scores on this questionnaire mean for patients’ improvements in their eczema symptoms. It looked at how 300 children in the UK answered the POEM. It calculated what level of change in scores needs to occur to show a real change in the symptoms rather than just random error in the way people have answered the questions. It also calculated the minimum change that can be seen as meaningful to patients and healthcare professionals. There are a number of different methods available for calculating this so the study included five different methods. Looking at all the results together, the researchers were able to provide some guidelines on how to interpret change in this questionnaire. If scores have changed by 2 points or fewer, this is unlikely to be a change beyond measurement error. A change of 2.1 to 2.9 points is a small change detected that is likely to be beyond measurement error but may not be clinically (medically) important. A change of 3 to 3.9 points is probably a clinically important change. A change of 4 points or over is very likely to be a clinically important change.
<i>Mental Diseases</i>. A Text-Book of Psychiatry for Medical Students and Practitioners. By R. H. Cole, M. D. (Lond.), M. R. C. P., etc. (<i>London: University of London Press. Published for the University of London Press by Hodder &amp; Stoughton, Warwick Square E. C., 1913</i>.)
Journal: American Journal of Psychiatry (1914)
THE LIGHT CURE IN LEPROSY.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiac arrhythmias during oral surgery with halothane-nitrous-oxide-oxygen anesthesia
Authors: C. Fisch
Journal: JAMA (1969)

Electrocardiograms were recorded continuously during 103 consecutive oral surgical procedures in 65 apparently healthy individuals anesthetized with intravenously administered methohexital (Brevital) sodium followed by inhalation of halothane-nitrous-oxide-oxygen mixture. Cardiac arrhythmias were recorded in 44 (42.7%) of the 103 procedures, with more than one arrhythmia recorded in each of 16 patients. The incidence of the arrhythmias rose sharply with beginning of the surgery and declined equally abruptly with its termination, suggesting reflex stimulation and simultaneous "sensitization" by the anesthetic, most likely halothane. Because of the potentially serious nature of many of the arrhythmias encountered, we suggest that this form of anesthetic not be used routinely for oral surgery in an outpatient setting unless the equipment and personnel for prompt resuscitation are available.
<i>QuickStats:</i> Prevalence* of Untreated Dental Caries<sup /><sup />in Permanent Teeth Among Children and Adolescents Aged 6–19 Years, by Age Group — National Health and Nutrition Examination Survey, United States, 2011–2014
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

During 2011-2014, 13.3% of children and adolescents aged 6-19 years had untreated dental caries in their permanent teeth. The percentage of children and adolescents with untreated dental caries increased with age: 6.1% among those aged 6-11 years, 14.5% among those aged 12-15 years, and 22.6% among those aged 16-19 years.
Cheap, smuggled tobacco makes it harder to give up smoking
Journal: BMJ (2001)

Evidence on health effects of housing improvements is scarce Despite strong observational evidence linking housing and health, it is still not known if housing improvements can improve health.Thomson et al (p 187) conducted a systematic review of studies of housing interventions on health.Although many of the studies found that health improved after the interventions, the studies were small and often did not adjust for potential confounding factors.
11. Routine Blood Cultures
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMA Committee on Aging Sums Up Its Work at Buffalo Meeting
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correlation of stomatitis and cutaneous toxicity with clinical outcome in patients with metastatic renal cell carcinoma treated with everolimus.
Authors: Lorena Rossi, Matteo Santoni, Matelda Medri, Emanuela Scarpi, Luciano Burattini, Salvatore Luca Burgio, Agnese Savini, Rossana Berardi, Ignazio Stanganelli, Stefano Cascinu, Dino Amadori, Ugo De Giorgi
Journal: Journal of Clinical Oncology (2013)

e15529 Background: We assessed the incidence and clinical presentation of stomatitis and cutaneous toxicity associated with everolimus in patients (pts) with metastatic renal cell carcinoma (mRCC). Correlation between these toxicities and clinical outcome was also determined. Methods: We retrospectively reviewed the clinical data of pts with mRCC treated with everolimus in two Italian Centers. Clinical evidence of stomatitis and/or cutaneous toxicity inducing a treatment discontinuation or a dose reduction were considered stomatitis-cutaneous toxicity events (SCTE). SCTE were evaluated and corresponding clinical data were reviewed for response and clinical outcome. Response was evaluated according to Response Evaluation Criteria in Solid Tumours (RECIST) criteria. Results: The study population consisted of 79 mRCC pts treated everolimus (57 male, 22 female; median age 69 years, range 44–88). Fifty-two pts (66%) received everolimus as second-line therapy, while 27 (34%) as third-line. SCTE were seen in 20/79 pts (25%) at a median of 30.5 days on everolimus treatment (range 10–270 days). Tumor response was evaluable in 77 of 79 patients (19 of 20 SCTE pts and 58 of 59 non-SCTE). Partial response or stable disease was achieved in 15 of 19 pts with SCTE (79%) compared to 28 of 58 (48%) with no SCTE (p = 0.03). After a median follow-up of 19 months (range, 1 to, 39), the median progression-free survival (PFS) was 5.5 months (95% CI 3.4-7.7) and the median overall survival (OS) was 17.2 months (95% CI 13.2-24.4). A significant difference was found in the median PFS equal to 7.5 months (95% CI 3.4-24.4) in SCTE pts vs 3.7 months (95% CI 2.7-7.5) in non-SCTE, p = 0.047, and in the median OS equal to 30.6 months (95% CI 14.8-not reached) in SCTE pts vs 14.0 months (95% CI 9.9-17.7) in non-SCTE, p = 0.004. Conclusions: These data suggest that SCTE may be a predictive marker of favorable outcome in mRCC treated with everolimus. A prospective observational study with a dermatologic/stomatologic monitoring has been planned in mRCC pts treated with everolimus.
Cholinergic dermographism
Authors: S.C. MAYOU, A.KOBZA BLACK, R.A.J. EADY, M.W. GREAVES
Journal: British Journal of Dermatology (1986)

Journal Article Cholinergic dermographism Get access S.C. MAYOU, S.C. MAYOU St John's Hospital for Diseases of the Skin, Lisle Street, Leicester Square, London WC2H 7BJ Search for other works by this author on: Oxford Academic Google Scholar A.KOBZA BLACK, A.KOBZA BLACK Institute of Dermatology, Homerton Grove, London E9 6BX, U.K. Dr A.Kobza Black. Search for other works by this author on: Oxford Academic Google Scholar R.A.J. EADY, R.A.J. EADY Institute of Dermatology, Homerton Grove, London E9 6BX, U.K. Search for other works by this author on: Oxford Academic Google Scholar M.W. GREAVES M.W. GREAVES Institute of Dermatology, Homerton Grove, London E9 6BX, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue 3, 1 September 1986, Pages 371–377, https://doi.org/10.1111/j.1365-2133.1986.tb05754.x Published: 01 September 1986 Article history Accepted: 20 February 1986 Published: 01 September 1986
FANCL Ubiquitinates Beta-Catenin and Enhances Its Nuclear Function
Authors: Kim-Hien T. Dao, Michael D. Rotelli, Curtis L. Petersen, Brie R. Brown, Whitney D. Nelson, Jane E. Yates, Amy Hanlon Newell, Susan B. Olson, Brian J. Druker, Grover C. Bagby
Journal: Blood (2011)
Cases of Nerve-Disorder, Recorded with Reference to the Probable Operation of Malaria as a Cause
Authors: C. H. Jones
Journal: BMJ (1857)

and probably the patient's sight as well; and if in parallel cases we could -et at the mucous nmembrane of the larynx and pharynx, and apply the same solution to it, I think the result would be as satisfactory.N.B.Only one of these five cases was under my care ; the other particulars I obtained subsequently from the mother, a very intelligent woman.
Licensure and certification in the United States. Present development and future plans
Authors: J. H. Morton
Journal: JAMA (1977)

LICENSURE and specialty board certification have changed substantially in the United States during the past decade. There are already signs of other important changes on the horizon. Some of the potential future changes are positive ones and deserve support from the medical profession; others, when viewed from the perspectives of the state licensing boards and the medical specialty boards with their responsibilities for assuring the competence of physicians, are alarming. <h3>PRESENT ACHIEVEMENTS</h3> What has been accomplished to date? Undoubtedly, the major advance is the progress of the Federated Licensing Examination (FLEX). The examination was offered for the first time in June 1968. At that time, 632 candidates from seven states took the complete examination. In June or December 1975, every state except Florida used FLEX as its licensing examination, and Florida recognized FLEX for endorsement. In addition, candidates were examined from the District of Columbia, Puerto Rico, the Canal Zone,
THE MARRIAGE OF CONSUMPTIVES.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal