tbuckley/cabot-search huggingface dataset:
A 'Supersalivation Syndrome'
Authors: Albert J. Miller
Journal: JAMA (1984)

<h3>To the Editor.—</h3> For about ten years I have had an esophageal reflux syndrome characterized by recurrent epigastric distress, "heartburn," and awakening at night with sour regurgitation and rather severe epigastric pain. The pain, also sometimes present in the lower retrosternal area, feels like a spasm. What has been striking, however, is the remarkable, exuberant outpouring of saliva that occurs with the pain. They go together when the pain is more severe; milder pains may not be associated with the salivary hyperfunction. When it occurs, the salivary outpouring forces almost continuous swallowing and at times is itself more disconcerting than the pain. The epigastric and lower retrosternal pain is relieved by sitting up and drinking hot water or by sucking on an antacid tablet. Even the severe pain is relieved in a few minutes, although a vague residual discomfort may persist for up to 30 minutes. All the symptoms are
Colorectal/Anorectal Posters
Authors: C. Eastwood, G.J. Davies, F.K. Gardiner, P.W. Dettmar
Journal: Gut (2001)

1998 to June 2000 were notified on the monthly report card distributed to all consultant gastroenterologists and gastrointestinal surgeons.The reporting doctor then completed a questionnaire detailing the age and clinical presentation of the patients, tumour site, hormone assay level, and method of treatment.Survival data were obtained at the end of the study period.244 cases were reported, including 32 prevalent cases and 2 inappropriate tumours.57% of these cases had questionnaires completed, producing 106 cases for analysis.64 had symptoms attributable to the hormonal eVects of the tumours, such as peptic ulceration or diarrhoea, and 42 had non-hormonal symptoms such as bowel obstruction, or extragastrointestinal symptoms such as rash or confusion.The commonest tumours producing hormonal GI symptoms were carcinoids (n=44, 69%), presenting with diarrhoea as the main symptom in 83%.Other symptoms included flushing, weight loss or abdominal pain.80% had liver metastases demonstrated at presentation.Gastrinomas accounted for 20% (n=13) of the tumours, presenting with peptic ulceration in 77%, and diarrhoea in 62%.Other tumours identified were VIPomas, phaeochromocytomas, thyroid medullary tumours, insulinomas, glucagonomas, somatostatinomas, hyperparathyroid tumours, and spindle cell tumours.78% of all patients were alive at the end of the study period.Carcinoid syndrome was the commonest neuroendocrine condition causing gastrointestinal symptoms.Diarrhoea appears to be a more common presenting symptom of gastrinomas than has previously been appreciated.With a series of tumours as large as in any previous UK survey, the BSG monthly surveillance system shows promising potential.
Use of Immunofluorescence for Detection of Specific Membrane Antigen in Simian Virus 40-Infected Nontransformed Cells
Authors: Tatiana E. Kluchareva, Kira L. Shachanina, Sophia Belova, Valentina Chibisova, Galina I. Deichman
Journal: JNCI Journal of the National Cancer Institute (1967)

Two kinds of immune hamster sera were compared in indirect immunofluorescence tests with the live cells of tumors induced by simian virus 40 (SV40). Both behaved similarly in all positive and negative control systems. The presence of specific-membrane cell antigen in SV40 tumor cells was confirmed. The dynamics of specific-membrane cell antigen in human- and hamster-embryo tissue-culture cells after. infection with SV40 was studied with the immunofluorescence test. One hour after infection, membrane cell antigen was demonstrated in human cells. Six hours after infection, immunofluorescence indexes in both types of cells almost reached the maximum and did not change significantly during the subsequent days of observation. Inoculation of adult hamsters with SV40-infected, morphologically nontransformed cells (10–12 days after infection) induced resistance in recipients to challenge with SV40 tumor cells, though the immunizing material contained no detectable amount of virus or SV40 morphologically transformed cells.
Arterial blood gases and acid-base balance
Authors: P. C Matthews, A. Steele
Journal: BMJ (1999)

Guideline for primary care management of dementia Such guidelines should consider all relevant effective treatmentsEditor-Evidence based guidelines have a responsibility to consider all the relevant effective treatments and not to concentrate only on those with which clinicians are familiar.I was surprised by a serious omission from the North of England evidence based guidelines for the primary care management of dementia 1 -of category I evidence for the effectiveness of Ginkgo biloba extract in dementia, from a large randomised controlled trial. 2 The number needed to treat for a 4 point improvement in the cognitive subscale of the Alzheimer's disease assessment scale at one year of follow up has been calculated as 7.9 (95% confidence interval 4.2 to 67); for a significant improvement in the geriatric assessment by relative's rating instrument (a daily living and social behaviour score assessed by family members) it was 7.0 (3.3 to 97).The dose of G biloba extract was 120 mg a day. 3 G biloba extract is available over the counter, and the cost of a year's treatment (from one major supermarket) is £85.A year's treatment with donepezil, by contrast, costs £891 for 5 mg and £1248 for 10 mg.
The American Public Health Association.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Smith-McGuckin Spot
Authors: Charles W Smith
Journal: Journal of the Royal Society of Medicine (1985)

Direct inspection of the tympanic membrane, especially with the help of the microscope, continues to be an important part of the examination of the patient suffering from ear disease. Accurate assessment of the varied appearances can be helpful in anticipating the prognosis in SMOM and may give information about the pathology of CSOM and cholesteatoma. The Smith-McGuckin spot was first described 20 years ago (Smith 1964, R Thomas 1965, personal communication) and its significance is reviewed. Further evidence of the relationship between skeletal disorders such as Turner's syndrome and persistent SMOM is described. It is suggested that bone resorption in the deep meatus, outer attic wall and ossicles may result from chronic hyperaemia rather than sepsis or avascular necrosis. The part played by cholesteatoma in bone erosion is questioned.
The Mechanics of the Digestive Tract.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"Augmented" Gastric Analysis
Authors: Norman I. Blum
Journal: JAMA (1965)

GASTRIC ANALYSES based on maximal stimulation with histamine (beta-imidazolyethyl-amine) or betazole hydrochloride (Histalog) are becoming more popular in evaluating acid secretion. Potentially dangerous side effects can occur with the augmented doses of these drugs even with the combined use of antihistamine drugs. Histamine as a gastric acid stimulus was originally used in a dose of 0.01 mg/kg of body weight of histamine acid phosphate.<sup>1</sup>With this dose the only reported side effects have been flushing, headache, and occasional mild, transient hypotension.<sup>2</sup> Kay, in 1953, demonstrated that increasing the dose of histamine acid phosphate from 0.01 mg/kg of body weight to 0.04 mg/kg resulted in a progressive increase of the gastric acid output.<sup>3</sup>Because this dose was felt to represent "maximal" stimulation, the augmented histamine response formed the basis of a test of gastric acid secretion, which has increased in popularity. In the original work with the higher
Antenatal screening for Down's syndrome.
Authors: N. Wald, J. Densem, A. Kennard
Journal: BMJ (1992)

refuse this we give 2 mg phytomenadione (vitamin KI) orally at birth and at 12 and 24 hours of age.We await information on the efficacy of this oral regimen.Recent work by Cornelissen et al will further fuel the controversy as they suggest that a single dose of vitamin K, whether given orally or intramuscularly, is insufficient to protect against late haemorrhagic disease of the newborn.'I wonder whether, in the meantime, the adverse publicity surrounding vitamin K will result in a resurgence of this preventable condition; I hope that it remains a condition that is rarely seen.
Inhibition by Tumor-Promoting Phorbol Esters of Procollagen Synthesis in Promotable JB6 Mouse Epidermal Cells
Authors: L. David Dion, Jenifer Bear, John Bateman, Luigi M. De Luca, Nancy H. Colburn
 6
Journal: JNCI Journal of the National Cancer Institute (1982)

The JB6 mouse epidermal cell line has been developed to study promotion of neoplastic transformation in vitro. Treatment of JB6 cells with 12-0-tetradecanoylphorbol 13-acetate (TPA) or other tumor promoters resulted in the irreversible acquisition by JB6 cells of tumorigenicity in nude mice and anchorage-independent growth in soft agar. As previously reported, one of the biochemical responses that occurs during TPA treatment is a greater than 75% reduction in a mannose-Iabeled glycoprotein with an apparent molecular weight of 180,000. This TPA-sensitive glycoprotein has now been identified on the basis of collagenase and pepsin sensitivity as procollagen pro-α1(I) chain. [3H]proline labeling also demonstrated a parallel decrease in the 150,000 procollagen pro-α2(I)component. Two nonphorbol promoters, mezerein and epidermal growth factor, were also active in decreasing procollagen synthesis. Promotion-sensitive and promotion-resistant clonal derivatives of JB6 showed similar basal levels of collagen synthesis as well as similar degrees of TPA-dependent procollagen loss indicating that the collagen decrease may be necessary but is not sufficient to produce the promotion response. Comparison of chemically transformed mouse epidermal cell lines with paired nontransformants suggests that reduced procollagen synthesis is a stably acquired phenotypic change and may therefore be involved in maintenance of the transformed phenotype as well as in its induction.
Resident Work Hours and the American Board of Medical Specialties
Authors: Bertrand M. Bell
Journal: JAMA (1991)

<h3>To the Editor. —</h3> An item in the November 21, 1990, Resident Forum (<i>JAMA</i>1990;264:2476) reporting on the veto by the American Board of Medical Specialties (ABMS) of the language regarding limits on work hours for resident physicians is most sad and another occasion for hanging crepe for the medical profession. With the public who, after all, funds graduate education, enunciating a clear message that they are dissatisfied with the current structure of graduate medical education, both in terms of hours and supervision, it has seemed to some of us who are intimately involved with this issue that it was of desperate importance for organized medicine to take a stand that would satisfy public concern. This was accomplished after much discussion and thought by the American Board of Internal Medicine, the American Medical Association, the Association of American Medical Colleges, the Accreditation Council for Graduate Medical Education (ACGME), and other
ANAPHYLAXIS IN DEMETHYLCHLORTETRACYCLINE
Authors: MACY I. LEVINE
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 August 1969ANAPHYLAXIS IN DEMETHYLCHLORTETRACYCLINEMACY I. LEVINE, M.D.MACY I. LEVINE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-2-434 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:A third corollary may be added to those drawn by Furey and Tan in their article, "'Anaphylactic Shock Due to Oral Demethylchlortetracycline" (Ann. Intern. Med. 70: 357, 1969). The treatment of anaphylactic reactions begins with the administration of epinephrine and antihistaminic agents. Many authorities would withhold corticoid drugs unless there is failure to respond within a reasonable time. There can be serious doubt about the value of such agents in the immediate life-threatening situation, since the time required for steroid therapy to show results is usually longer than the duration of most anaphylactic reactions. In any event,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 3347 Forbes Ave. Pittsburgh, Pa. 15213 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1969Volume 71, Issue 2Page: 434-434KeywordsAnaphylaxisDrugsEpinephrineShockSteroid therapy Issue Published: 1 August 1969 PDF downloadLoading ...
Hospital admissions of asthmatics bv age and sex
Authors: T. Harju, T. Keistinen, T. Tuuponen, S.‐L. Kivelä
Journal: Allergy (1996)

Asthma‐related hospital admissions and the occurrence of new admissions were studied by age and sex in order to find the groups of asthmatics with high hospital admission rates. Data from the Finnish discharge register for 1972–92 were used to analyze the number of hospital admissions caused by asthma (defined in the International Clussification of Diseases , 8th and 9th revisions, code 493) and occurrence of new asthma admissions between 1983 and 1992. A total of 192195 asthma‐induced treatment periods were identified, 91 223 for males and 100972 for females. Boys were admitted twice as often as girls at the age of 1 year (11.2 in comparison with 5.9 admissions per 1000 per year), whereas the admission rate was consistently higher among women 25–55 years of age. The highest asthma admission rate among the elderly was at age 73 for men (10.3 per 1000) and 75 for women (9.5 per 1000). Occurrences of new asthma admissions were most frequent at the age of 1 year (5.3 per 1000 for boys and 2.9 per 1000 for girls) and remained constant among those aged 50–80 years. Asthma is not only a disease of childhood and adolescence. The number of middle‐aged and elderly asthmatics requiring hospitalization is markedly high.
The use of Acrylic Bone Cement for Cervical Fusion in Patients with Rheumatoid Arthritis
Authors: G P Wilde, J S Hopkins
Journal: Journal of the Royal Society of Medicine (1988)

We report on 14 patients with instability of the cervical spine secondary to rheumatoid arthritis treated by fusion using a combination of traditional bone grafting techniques and methylmethacrylate bone cement. Successful fusion was achieved in all cases with few complications. The high infection rate reported by other authors was avoided by reducing the bulk of the cement mass and the use of antibiotic impregnated cement. We recommend this method of fusion to all orthopaedic surgeons involved in the treatment of patients with rheumatoid arthritis.
Career Mobility in Allied Health Education
Authors: J. Warren Perry
Journal: JAMA (1969)

So much has been said about the concept of career mobility and so little has been done to implement this concept that we are immediately faced with the simple questions: Is the idea of "career mobility" fiction or fact? Is it a philosophical fable or can it be translated into reality? In the brief time that I have, I would like to examine some of the needs for career mobility; some of the factors which might make it work: a few of the attempts already in operation; and finally, where do we go from here? This may sound more like the outline for a book than for a 20-minute speech, but it gives you an idea of the breadth of this much-discussed subject. The idea of "career ladder" has come into prominence at a time when health education and health professionals are attempting to answer the dilemma of the century:
Urologists Present Positive Evidence for Early Test
Authors: Mike Mitka
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
POS0333 CIRCULATING NON-CLASSICAL CD14low/-CD16+ MONOCYTES AND THEIR EXPRESSION OF ARGINASE-1 ARE ASSOCIATED WITH THE ACTIVITY OF AXIAL SPONDYLOARTHRITIS
Authors: T. Tyrinova, A. Morenkova, M. Tikhonova, O. Chumasova, N. Ilina, A. Fedorova, A. Sizikov, A. Ostanin, E. Chernykh
Journal: Annals of the Rheumatic Diseases (2022)

Background Human peripheral blood monocytes represent heterogeneous population and can be divided into three major populations, classical (CD14 ++ CD16 − ), intermediate (CD14 ++ CD16 + ) and non-classical (CD14 + CD16 ++ ) monocytes. All three monocyte populations are thought to have different functional activity, including their pro- and anti-inflammatory activity. The ratio between monocyte populations could change in inflammatory conditions that it is thought to be important for the development of adequate immune responses. Axial spondyloarthritis (axSpA) being autoimmune diseases is currently classified as an autoinflammatory disease based on a strong inflammatory component. It is accepted that increased concentration of pro-inflammatory mediators can cause an impairment of myelopoiesis. Objectives The present study aimed to analyze the frequency of blood monocyte subpopulations and their expression of the suppressor molecule arginase-1 (Arg1) in patients with axSpA. Methods The study included 14 healthy donors and 19 axSpA patients aged 23 to 59 years, including 15 men and 4 women. Ankylosing Spondylitis Disease Activity Score (ASDAS) was used to assess disease activity and high activity was determined as ASDAS≥2.1. The disease duration at the time of the study was 12 years (median). Phenotypic analysis of blood monocytes was performed by flow cytometry based on CD14 and CD16 expression. Results The frequency of monocyte subpopulations in patients with low/moderate activity of axSpA did not differ from the donor group. Patients with high/very high disease activity showed an increased relative number of non-classical CD14 low/- CD16 + monocytes (vs donors p U =0.007). All donor monocyte subpopulations expressed suppressor intracellular molecule Arg1 with higher expression in intermediate and non-classical monocytes. The expression of Arg1 in CD14 low/- CD16 + monocytes was significantly reduced in patients with high activity (vs donors Me 41.5 vs 76.5%, p U =0.01). Patients with the presence of peripheral articular manifestations of axSpA were characterized by a decreased Arg1 expression in non-classical monocytes compared with the donor group (p U =0.02). However, patients without peripheral manifestations demonstrated a significant reduction of Arg1 expression in all monocyte subpopulations (p U &lt;0.05). Conclusion Shifting of monocyte subpopulation toward a higher number of non-classical monocytes with the decrease in the expression of the suppressor molecule Arg1 in the high activity of axSpA can play important role in terms of the possible involvement of monocytes in maintaining inflammation and its regulation in autoinflammatory disease. The reported study was funded by State Budgeted Project (registration ID 122011800324-4, 122011800108-0, 122012000373-3). Disclosure of Interests None declared
A Reference Handbook of the Medical Sciences. Embracing the Entire Range of Scientific and Practical Medicine and Allied Science.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal