POS0997 CLINICAL FEATURES OF UVEITIS ASSOCIATED TO SPONDYLOARTHRITIS. SINGLE CENTER UNIVERSITY STUDY.
Authors: L. Sanchez-Bilbao, I. Gonzalez-Mazon, A. Herrero-Morant, A. De Vicente-Delmás, V. Calvo-Río, D. Martínez-López, J. Rueda-Gotor, M. J. García-García, N. Palmou-Fontana, M. A. González-Gay, R. Blanco
Journal: Annals of the Rheumatic Diseases (2022)

Background Uveitis is a frequent extraarticular manifestation of spondyloarthritis (SpAs). It has been classically reported that whereas uveitis in axial spondyloarthritis (ax-SpA) is predominantly anterior, unilateral, acute, and non-recurrent; in psoriatic arthritis (PsA) and in inflammatory bowel disease (IBD) it has been described as posterior, bilateral, insidious, and continuous [1,2]. Objectives In a large unselected series of SpAs, our aim was to assess the epidemiology and clinical features of SpAs-associated uveitis. Methods Study of consecutive patients from a single University Hospital with a ) ax-SpA, b ) PsA, and c ) IBD (Crohn’s disease and Ulcerative colitis). We have selected patients with uveitis that were classified according to Standarization Uveitis Nomenclature (SUN) Working Group. Main general features, and uveitis pattern, location and onset were recorded. Results We studied 2156 (1038 women/118 men) patients with SpAs: IBD (n= 1449; 67.2%); PsA (n= 406; 18.8%); and ax-SpA (n= 301; 14%). Uveitis was present in 87 (4%) (102 eyes) of 2156 patients with SpAs. However, uveitis occurs with varying frequency according to the SpAs subtype:14.6% of axSpA (n=44), 4.9% of PsA (n=20), and 1.6% of IBD (n=23) (Table 1). In the global SpAs, the most common pattern of uveitis was typically anterior (n=78; 89.7%), unilateral (n=72; 82.8%), acute (n=19; 82.6%), and non-recurrent (n=83; 95.4%). The comparative study between these three groups of SpAs showed a significant greater frequency of HLA-B27 positive, anterior location and acute onset in ax-SpA-related uveitis (Table 1). Table 1. Main clinical features and uveitis pattern. Ax-SpA (n=44 ) PsA (n=20 ) IBD (n=23 ) p Main general features Age, years, mean ±SD 45.6 ± 10.3 43.1 ± 14.5 49.1 ± 14.6 0.472 Sex, w/m, n, (% of women) 25/19 (56.8) 12/8 (60) 17/6 (73.9) 0.382 Disease Duration, years, mean±SD 18.6 ± 10.5 9.9 ± 8.2 17.4 ± 10.2 0.067 HLA-B27 positive, n (%) 37 (84.1) 9 (45) 5 (2.8) 0.001* Uveitis location Anterior, n (%) 44 (100) 16 (80) 18 (78.3) 0.006* Posterior, n (%) 0 (0) 0 (0) 4 (17.4) - Panuveitis, n (%) 0 (0) 0 (0) 1 (4.5) - Uveitis pattern Unilateral, n (%) 37 (84.1) 16 (80) 19 (82.6) 0.922 Uveitis onset Acute, n (%) 44 (100) 20 (100) 19 (82.6) 0.003* Conclusion Although SpAs associated uveitis have different frequencies depending on the underlying disease, they share the same clinical pattern: anterior, unilateral, acute, and non-recurrent, in contrast with published data from selected series. References [1]Paiva ES, et al. Characterisation of uveitis in patients with psoriatic arthritis. Ann Rheum Dis. 2000; 59:67-70. [2]Lyons JL, Rosenbaum JT. Uveitis associated with inflammatory bowel disease compared with uveitis associated with spondyloarthropathy. Arch Ophthalmol. 1997;115:61-4. Disclosure of Interests None declared