tbuckley/cabot-search huggingface dataset:
Safety and Activity of Immune Checkpoint Inhibitors in People Living With HIV and Cancer: A Real-World Report From the Cancer Therapy Using Checkpoint Inhibitors in People Living With HIV-International (CATCH-IT) Consortium
Authors: Talal El Zarif, Amin H. Nassar, Elio Adib, Bailey G. Fitzgerald, Jiaming Huang, Tarek H. Mouhieddine, Paul G. Rubinstein, Taylor Nonato, Rana R. McKay, Mingjia Li, Arjun Mittra, Dwight H. Owen, Robert A. Baiocchi, Michael Lorentsen, Christopher Dittus, Nazli Dizman, Adewunmi Falohun, Noha Abdel-Wahab, Adi Diab, Anand Bankapur, Alexandra Reed, Chul Kim, Aakriti Arora, Neil J. Shah, Edward El-Am, Elie Kozaily, Wassim Abdallah, Ahmad Al-Hader, Batool Abu Ghazal, Anwaar Saeed, Claire Drolen, Melissa G. Lechner, Alexandra Drakaki, Javier Baena, Caroline A. Nebhan, Tarek Haykal, Michael A. Morse, Alessio Cortellini, David J. Pinato, Alessia Dalla Pria, Evan Hall, Veli Bakalov, Nathan Bahary, Aarthi Rajkumar, Ankit Mangla, Vishal Shah, Parminder Singh, Frank Aboubakar Nana, Nerea Lopetegui-Lia, Danai Dima, Ryan W. Dobbs, Pauline Funchain, Rabia Saleem, Rachel Woodford, Georgina V. Long, Alexander M. Menzies, Carlo Genova, Giulia Barletta, Sonam Puri, Vaia Florou, Dame Idossa, Maristella Saponara, Paola Queirolo, Giuseppe Lamberti, Alfredo Addeo, Melissa Bersanelli, Dory Freeman, Wanling Xie, Erin G. Reid, Elizabeth Y. Chiao, Elad Sharon, Douglas B. Johnson, Ramya Ramaswami, Mark Bower, Brinda Emu, Thomas U. Marron, Toni K. Choueiri, Lindsey R. Baden, Kathryn Lurain, Guru P. Sonpavde, Abdul Rafeh Naqash
Journal: Journal of Clinical Oncology (2023)

Compared with people living without HIV (PWOH), people living with HIV (PWH) and cancer have traditionally been excluded from immune checkpoint inhibitor (ICI) trials. Furthermore, there is a paucity of real-world data on the use of ICIs in PWH and cancer.
High-Resolution Computed Tomography-approximated Perfusion Is Comparable to Nuclear Perfusion Imaging in Severe Chronic Obstructive Pulmonary Disease
Authors: T. David Koster, Jean-Paul Charbonnier, Jan Pruim, Hester A. Gietema, Rein Posthuma, Lowie E. G. W. Vanfleteren, Marlies van Dijk, Karin Klooster, Dirk-Jan Slebos
Journal: American Journal of Respiratory and Critical Care Medicine (2023)

"HRCT-Approximated Perfusion is Comparable to Nuclear Perfusion Imaging in Severe COPD." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
Serum IL-8 as a Determinant of Response to Phosphodiesterase-4 Inhibition in Chronic Obstructive Pulmonary Disease
Authors: Mirco Govoni, Michele Bassi, Debora Santoro, Sinéad Donegan, Dave Singh
Journal: American Journal of Respiratory and Critical Care Medicine (2023)

Phosphodiesterase-4 (PDE4) inhibitors have demonstrated increased efficacy in patients with chronic obstructive pulmonary disease who had chronic bronchitis or higher blood eosinophil counts. Further characterization of patients who are most likely to benefit is warranted.
Association of Noninvasive Respiratory Support with Extubation Outcomes in Brain-injured Patients Receiving Mechanical Ventilation: A Secondary Analysis of the ENIO Prospective Observational Study
Authors: Shaurya Taran, Camilo Diaz-Cruz, Bastien Perrot, Pablo Alvarez, Daniel Agustin Godoy, Mohan Gurjar, Matthias Haenggi, Julio Cesar Mijangos, Paolo Pelosi, Chiara Robba, Marcus J. Schultz, Yoshitoyo Ueno, Karim Asehnoune, Sung-Min Cho, Christopher J. Yarnell, Raphael Cinotti, Robert D. Stevens
Journal: American Journal of Respiratory and Critical Care Medicine (2023)

Rationale: Noninvasive respiratory support using a high-flow nasal cannula (HFNC) or noninvasive positive pressure ventilation (NIPPV) can decrease the risk of reintubation in patients being liberated from mechanical ventilation, but effects in patients with acute brain injury (ABI) are unknown. Objectives: To evaluate the association between postextubation noninvasive respiratory support and reintubation in patients with ABI being liberated from mechanical ventilation. Methods: This was a secondary analysis of a prospective, observational study of mechanically ventilated patients with ABI (clinicaltrials.gov identifier NCT03400904). The primary endpoint was reintubation during ICU admission. We used mixed-effects logistic regression models with patient-level covariates and random intercepts for hospital and country to evaluate the association between prophylactic (i.e., planned) HFNC or NIPPV and reintubation. Measurements and Main Results: 1,115 patients were included from 62 hospitals and 19 countries, of whom 267 received HFNC or NIPPV following extubation (23.9%). Compared with conventional oxygen therapy, neither prophylactic HFNC nor NIPPV was associated with decreased odds of reintubation (respectively, odds ratios of 0.97 [95% confidence interval, 0.54-1.73] and 0.63 [0.30-1.32]). Findings remained consistent in sensitivity analyses accounting for alternate adjustment procedures, missing data, shorter time frames of the primary endpoint, and competing risks precluding reintubation. In a Bayesian analysis using skeptical and data-driven priors, the probabilities of reduced reintubation ranged from 17% to 34% for HFNC and from 46% to 74% for NIPPV. Conclusions: In a large cohort of brain-injured patients undergoing liberation from mechanical ventilation, prophylactic use of HFNC and NIPPV were not associated with reintubation. Prospective trials are needed to confirm treatment effects in this population. Primary study registered with www.clinicaltrials.gov (NCT03400904).
Weighing the Risks and Benefits of <i>Pneumocystis Jirovecii</i> Pneumonia Prophylaxis in Rituximab Users
Authors: Zachary S. Wallace, Michael Putman
Journal: Arthritis & Rheumatology (2023)

Disclosure Form Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Antibodies to Neutrophil Extracellular Traps: Novel Markers for the Antiphospholipid Syndrome
Authors: David S. Pisetsky
Journal: Arthritis & Rheumatology (2023)

Disclosure form Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Why spend billions on hospital beds when you can care for patients at home?
Authors: Tessa Richards
Journal: BMJ (2023)

Why spend billions on hospital beds when you can care for patients at home?Patients and the public need to be actively involved in the development and spread of new "hospital at home" models of care including virtual wards, says Tessa Richards Tessa Richards associate editor It's not hard to see why interest in "Hospital at Home" programmes is escalating.
Leisure-time physical activity and mortality from influenza and pneumonia: a cohort study of 577 909 US adults
Authors: Bryant J Webber, Heather C Yun, Geoffrey P Whitfield
Journal: British Journal of Sports Medicine (2023)

To examine the association of leisure-time physical activity with mortality from influenza and pneumonia.A nationally representative sample of US adults (aged ≥18 years) who participated in the National Health Interview Survey from 1998 to 2018 were followed for mortality through 2019. Participants were classified as meeting both physical activity guidelines if they reported ≥150 min/week of moderate-intensity equivalent aerobic physical activity and ≥2 episodes/week of muscle-strengthening activity. Participants were also classified into five volume-based categories of self-reported aerobic and muscle-strengthening activity. Influenza and pneumonia mortality was defined as having an underlying cause of death with an International Classification of Diseases, 10th Revision code of J09-J18 recorded in the National Death Index. Mortality risk was assessed using Cox proportional hazards, adjusting for sociodemographic and lifestyle factors, health conditions and influenza and pneumococcal vaccination status. Data were analysed in 2022.Among 577 909 participants followed for a median of 9.23 years, 1516 influenza and pneumonia deaths were recorded. Compared with participants meeting neither guideline, those meeting both guidelines had 48% lower adjusted risk of influenza and pneumonia mortality. Relative to no aerobic activity, 10-149, 150-300, 301-600 and >600 min/week were associated with lower risk (by 21%, 41%, 50% and 41%). Relative to <2 episodes/week of muscle-strengthening activity, 2 episodes/week was associated with 47% lower risk and ≥7 episodes/week with 41% higher risk.Aerobic physical activity, even at quantities below the recommended level, may be associated with lower influenza and pneumonia mortality while muscle-strengthening activity demonstrated a J-shaped relationship.
The intratumor microbiome is associated with microsatellite instability
Authors: Doratha A Byrd, Wenyi Fan, K Leigh Greathouse, Michael C Wu, Hao Xie, Xuefeng Wang
Journal: JNCI Journal of the National Cancer Institute (2023)

Abstract Intratumoral microbes may have multifunctional roles in carcinogenesis. Microsatellite instability (MSI) is associated with higher tumor immunity and mutational burden. Using whole transcriptome and whole genome sequencing microbial abundance data, we investigated associations of intratumoral microbes with MSI, survival, and MSI-relevant tumor molecular characteristics across multiple cancer types including colorectal cancer (CRC), stomach adenocarcinoma, and endometrial carcinoma. Among 451 CRC patients, our key finding was strong associations of multiple CRC-associated genera, including Dialister and Casatella, with MSI. Dialister and Casatella abundance was associated with improved overall survival (hazard ratiomortality = 0.56, 95% confidence interval = 0.34 to 0.92, and hazard ratiomortality = 0.44, 95% confidence interval = 0.27 to 0.72), respectively, comparing higher relative to lower quantiles. Multiple intratumor microbes were associated with immune genes and tumor mutational burden. Diversity of oral cavity–originating microbes was also associated with MSI among CRC and stomach adenocarcinoma patients. Overall, our findings suggest the intratumor microbiota may differ by MSI status and play a role in influencing the tumor microenvironment.
Pre-clinical characterization of ISB 1342, a CD38xCD3 T-cell engager for relapsed/refractory multiple myeloma
Authors: Blandine Pouleau, Carole Estoppey, Perrine Suere, Emilie Nallet, Amélie Laurendon, Thierry Monney, Daniela Pais Ferreira, Adam Drake, Laura Carretero-Iglesia, Julie Macoin, Jeremy Berret, Maria Pihlgren, Marie-Agnes Doucey, Girish S Gudi, Vinu Menon, Venkatesha Udupa, Abhishek Maiti, Gautam Borthakur, Ankita Srivastava, Stanislas Blein, Lamine Mbow, Thomas Matthes, Zeynep Kaya, Claire M Edwards, James R Edwards, Emmanuelle Menoret, Charlotte Kervoelen, Catherine Pellat-Deceunynck, Philippe Moreau, Eugene Alexander Zhukovsky, Mario Perro, Myriam Chimen
Journal: Blood (2023)
Metabolic adaptation to tyrosine kinase inhibition in leukemia stem cells
Authors: Shaowei Qiu, Vipul Sheth, Chengcheng Yan, Juan Liu, Balu K. Chacko, Hui Li, David K. Crossman, Seth D. Fortmann, Sajesan Aryal, Ashley Rennhack, Maria B. Grant, Robert S. Welner, Andrew J. Paterson, Adam R. Wende, Victor M. Darley-Usmar, Rui Lu, Jason W. Locasale, Ravi Bhatia
Journal: Blood (2023)
Pathogenic helper T cells as the novel therapeutic targets for immune-mediated intractable diseases
Authors: Atsushi Onodera, Kota Kokubo, Mikiko Okano, Miki Onoue, Masahiro Kiuchi, Chiaki Iwamura, Tomohisa Iinuma, Motoko Y. Kimura, Nobuyuki Ebihara, Toyoyuki Hanazawa, Toshinori Nakayama, Kiyoshi Hirahara
Journal: Pharmacology & Therapeutics (2023)
WHO Global Position Paper and Implementation Strategy on kangaroo mother care call for fundamental reorganisation of maternal–infant care
Authors: Gary L Darmstadt, Betty Kirkwood, Shuchita Gupta, Gary L Darmstadt, Betty Kirkwood, Shuchita Gupta, Ebunoluwa Adejuyigbe, Rajiv Bahl, Maneesh Batra, Zulfiqar Bhutta, Tasmin Bota, Nathalie Charpak, Harish Chellani, Mickey Chopra, Teesta Dey, Queen Dube, Nicholas Embleton, Viviana Fernandez, Elizabeth Franklin, Meena Gandhi, Sumita Ghosh, Lars Gronseth, Tedbabe Degefie Hailegebriel, Aya Hasegawa, Bo Jacobsson, Lily Kak, Jan Lucas Ket, Tore Laerdal, Joy E Lawn, Silke Mader, Hema Magge, Sarmila Mazumder, Keiko Osaki, Janna Patterson, Luwei Pearson, Roberta Petrucci, Mihretab Salasibew, Abiy Seifu, Nalini Singhal, Peter Waiswa, Dilys Walker, Karen Walker, Steve Wall, Bjorn Westrup
Journal: The Lancet (2023)
Differences in clinical characteristics and outcomes between COVID-19 and influenza in critically ill adult patients: A national database study
Authors: Diane Naouri, Tai Pham, Martin Dres, Albert Vuagnat, Gaëtan Beduneau, Alain Mercat, Alain Combes, Antoine Kimmoun, Matthieu Schmidt, Alexandre Demoule, Matthieu Jamme
Journal: Journal of Infection (2023)
RSK2 inactivation cooperates with AXIN1 inactivation or β-catenin activation to promote hepatocarcinogenesis
Authors: Samantha Schaeffer, Barkha Gupta, Anna-Line Calatayud, Julien Calderaro, Stefano Caruso, Théo Z. Hirsch, Laura Pelletier, Jessica Zucman-Rossi, Sandra Rebouissou
Journal: Journal of Hepatology (2023)
Generalised joint hypermobility leads to increased odds of sustaining a second ACL injury within 12 months of return to sport after ACL reconstruction
Authors: Bálint Zsidai, Ramana Piussi, Roland Thomeé, David Sundemo, Volker Musahl, Kristian Samuelsson, Eric Hamrin Senorski
Journal: British Journal of Sports Medicine (2023)

To determine the 12-month risk of a second anterior cruciate ligament (ACL) injury in a population of patients with and without generalised joint hypermobility (GJH) who return to sports (RTS) at competition level after ACL reconstruction (ACL-R).Data were extracted from a rehabilitation-specific registry for 16-50-year-old patients treated with ACL-R between 2014 and 2019. Demographics, outcome data and the incidence of a second ACL injury within 12 months of RTS, defined as a new ipsilateral or contralateral ACL, were compared between patients with and without GJH. Univariable logistic regression and Cox proportional hazards regression were performed to determine the influence of GJH and time of RTS on the odds of a second ACL injury, and ACL-R survival without a second ACL injury after RTS.A total of 153 patients, 50 (22.2%) with GJH and 175 (77.8%) without GJH, were included. Within 12 months of RTS, 7 (14.0%) patients with GJH and 5 (2.9%) without GJH had a second ACL injury (p=0.012). The odds of sustaining a second ipsilateral or contralateral ACL injury were 5.53 (95% CI 1.67 to 18.29) higher in patients with GJH compared with patients without GJH (p=0.014). The lifetime HR of a second ACL injury after RTS was 4.24 (95% CI 2.05 to 8.80; p=0.0001) in patients with GJH. No between-group differences were observed in patient-reported outcome measures.Patients with GJH undergoing ACL-R have over five times greater odds of sustaining a second ACL injury after RTS. The importance of joint laxity assessment should be emphasised in patients who aim to return to high-intensity sports following ACL-R.
Neoadjuvant immunotherapy for melanoma is now ready for clinical practice
Authors: Claus Garbe, Reinhard Dummer, Teresa Amaral, Rodabe N. Amaria, Paolo A. Ascierto, Elizabeth M. Burton, Brigitte Dreno, Alexander M. M. Eggermont, Axel Hauschild, Christoph Hoeller, Roland Kaufmann, Celeste Lebbe, Mario Mandala, Alexander M. Menzies, David Moreno, Olivier Michielin, Paul Nathan, Sapna P. Patel, Caroline Robert, Dirk Schadendorf, Paul C. Lorigan, Richard A. Scolyer, Hussein A. Tawbi, Bart A. van de Wiel, Christian Blank, Georgina V. Long
Journal: Nature Medicine (2023)
Housing Reparations as an Avenue to Counter the Impact of Structural Racism on Asthma
Authors: Neeta Thakur, Adali Martinez
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allergy to stings and bites from rare or locally important arthropods: Worldwide distribution, available diagnostics and treatment
Authors: Gunter Johannes Sturm, Elisa Boni, Darío Antolín‐Amérigo, Maria Beatrice Bilò, Christine Breynaert, Filippo Fassio, Kymble Spriggs, Arantza Vega, Luisa Ricciardi, Lisa Arzt‐Gradwohl, Wolfgang Hemmer
Journal: Allergy (2023)

Abstract Insect venom allergy is the most frequent cause of anaphylaxis in Europe and possibly worldwide. The majority of systemic allergic reactions after insect stings are caused by Hymenoptera, and among these, vespid genera induce most of the systemic sting reactions (SSR). Honey bees are the second leading cause of SSR. Depending on the global region, other Hymenoptera such as different ant genera are responsible for SSR. Widely distributed hornets and bumblebees or local vespid or bee genera rarely induce SSR. Hematophagous insects such as mosquitoes and horse flies usually cause (large) local reactions while SSR occasionally occur. This position paper aimed to identify either rare or locally important insects causing SSR as well as rarely occurring SSR after stings or bites of widely distributed insects. We summarized relevant venom or saliva allergens and intended to identify possible cross‐reactivities between the insect allergens. Moreover, we aimed to locate diagnostic tests for research and routine diagnosis, which are sometimes only regionally available. Finally, we gathered information on available immunotherapies. Major allergens of most insects were identified, and cross‐reactivity between insects was frequently observed. While some diagnostics and immunotherapies are locally available, standardized skin tests and immunotherapies are generally lacking in rare insect allergy.
Excess Mortality and Years of Potential Life Lost Among the Black Population in the US, 1999-2020
Authors: César Caraballo, Daisy S. Massey, Chima D. Ndumele, Trent Haywood, Shayaan Kaleem, Terris King, Yuntian Liu, Yuan Lu, Marcella Nunez-Smith, Herman A. Taylor, Karol E. Watson, Jeph Herrin, Clyde W. Yancy, Jeremy Samuel Faust, Harlan M. Krumholz
Journal: JAMA (2023)

Importance Amid efforts in the US to promote health equity, there is a need to assess recent progress in reducing excess deaths and years of potential life lost among the Black population compared with the White population. Objective To evaluate trends in excess mortality and years of potential life lost among the Black population compared with the White population. Design, setting, and participants Serial cross-sectional study using US national data from the Centers for Disease Control and Prevention from 1999 through 2020. We included data from non-Hispanic White and non-Hispanic Black populations across all age groups. Exposures Race as documented in the death certificates. Main outcomes and measures Excess age-adjusted all-cause mortality, cause-specific mortality, age-specific mortality, and years of potential life lost rates (per 100 000 individuals) among the Black population compared with the White population. Results From 1999 to 2011, the age-adjusted excess mortality rate declined from 404 to 211 excess deaths per 100 000 individuals among Black males ( P for trend &amp;amp;lt;.001). However, the rate plateaued from 2011 through 2019 ( P for trend = .98) and increased in 2020 to 395—rates not seen since 2000. Among Black females, the rate declined from 224 excess deaths per 100 000 individuals in 1999 to 87 in 2015 ( P for trend &amp;amp;lt;.001). There was no significant change between 2016 and 2019 ( P for trend = .71) and in 2020 rates increased to 192—levels not seen since 2005. The trends in rates of excess years of potential life lost followed a similar pattern. From 1999 to 2020, the disproportionately higher mortality rates in Black males and females resulted in 997 623 and 628 464 excess deaths, respectively, representing a loss of more than 80 million years of life. Heart disease had the highest excess mortality rates, and the excess years of potential life lost rates were largest among infants and middle-aged adults. Conclusions and relevance Over a recent 22-year period, the Black population in the US experienced more than 1.63 million excess deaths and more than 80 million excess years of life lost when compared with the White population. After a period of progress in reducing disparities, improvements stalled, and differences between the Black population and the White population worsened in 2020.
Errors in Data
Authors: Juan Xiu, Yuzhou Zhang, Jason Zhang, Jason Yam, Drs Yam, Xiu Juan
Journal: JAMA (2023)

Thomas A. LaVeist, PhD; Eliseo J. Pérez-Stable, MD; Patrick Richard, PhD, MA; Andrew Anderson, PhD; Lydia A. Isaac, PhD; Riley Santiago, MPH; Celine Okoh, MBA; Nancy Breen, PhD; Tilda Farhat, PhD, MPH; Assen Assenov, PhD; Darrell J. Gaskin, PhD
Fluvoxamine vs Placebo and Time to Recovery in Outpatients With Mild to Moderate COVID-19—Reply
Authors: Matthew W. McCarthy, Christopher J. Lindsell, Susanna Naggie
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal