tbuckley/cabot-search huggingface dataset:
Synergism or Antagonism Between Estradiol and Progesterone on the Cell Kinetic Parameters of the MXT Mouse Mammary Tumor&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Robert Kiss
 4, André J. Danguy, Jean-Claude Heuson, Robert J. Paridaens
Journal: JNCI Journal of the National Cancer Institute (1987)

With the use of an in vivo tritiated thymidine ([3H]dThd) nuclear labeling followed by autoradiography, the effects at different times before sacrifice of single or paired injections of 17β-estradiol (E2) and/or progesterone (Pg), at different concentrations, were studied in (C57BL × DBA/2f)F1 (B6D2F1) mice transplanted with the MXT hormone-sensitive mammary tumor. Uteri were chosen as controls for the methodology. With regard to MXT tumors, E2 (0.25, 2.50, or 25.00 μg/animal) or Pg (125, 600, or 5,000 μg/animal) exerts almost a similar mitogenic influence that is dose related for the former and not for the latter, at least within the range of concentrations studied here, and the mitogenic effect of Pg seems to appear earlier than that of E2. When these steroids are concomitantly given, no obvious synergistic or antagonistic effect can be observed. A second E2 administration seems to have a less pronounced effect on cell proliferation as compared to that exerted by the first injection performed 12 or 24 hours earlier. On the contrary, the repetition of a Pg treatment would rather exert an additive or even a synergistic effect on the tumoral dThd labeling indices with regard to the total duration of stimulation. When one of these two steroids is administered first, it blocks totally the mitogenic effect of the second, provided the latter is given 24 hours later. It is concluded that E2 and Pg have almost a similar mitogenic effect on the MXT tumor and that these hormones exert complex interactions that are probably very important for the growth regulation of this cancer. Further investigations are needed to better understand the precise biochemical mechanisms involved in the modulating actions of these steroids on the MXT mammary growth.
Nutritional Status and General Immune Competence in Patients with Head and Neck Cancer
Authors: Gerald B Brookes, Peter Clifford
Journal: Journal of the Royal Society of Medicine (1981)

Anergy to 2,4-dinitrochlorobenzene (DNCB) has been reported as a highly significant adverse prognostic immunological factor in several studies of patients with squamous cell carcinomas involving the head and neck. Patients with these tumours often present with concurrent nutritional deficiencies. This paper reports the findings of a prospective study into both the nutritional status and general immune competence of 53 such patients.Analysis of the results has demonstrated a statistically highly significant positive correlation between nutritional status and both the delayed hypersensitivity response to DNCB, and the pretreatment total lymphocyte count levels. It is suggested that nutritional deficit may be a primary adverse prognostic factor in this disease group, with immunoincompetence a secondary phenomenon, and supporting evidence is presented. The consequent probable importance of nutritional status with regard to clinical trials, and the necessity for controlled studies to determine the possible beneficial effect of nutritional support on `cure' rates, are discussed.
Toxic Shock Syndrome During an Influenza Outbreak
Authors: Steven J. Sperber
Journal: JAMA (1987)

TOXIC shock syndrome is a potentially fatal multisystem illness associated with<i>Staphylococcus aureus</i>infection and production of toxins. Although this syndrome usually occurs in menstruating women, we saw a case of fatal toxic shock syndrome in a young man who developed<i>S aureus</i>pneumonia during an influenza outbreak. <h3>Report of a Case</h3> A previously healthy 18-year-old male college student presented to a local hospital during an influenza outbreak with three days of fever, sore throat, myalgias, and diarrhea and one day of productive cough and dyspnea. His blood pressure was 80/60 mm Hg and his temperature was 39.4°C. He was admitted. Congested lung fields were noted. The leukocyte count was 3700/mm<sup>3</sup>(3.7×10<sup>9</sup>/L), with 18% (0.18) polymorphonuclear cells, 65% (0.65) band forms, 3% (0.3) lymphocytes, 1% (0.1) mononuclear cells, and 13% (0.13) metamyelocytes. The platelet count was 104000/mm<sup>3</sup>(104×10<sup>9</sup>/L) and the prothrombin and partial thromboplastin
Fellowships, Grants, Awards
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Fellowships, Grants, Awards Get access JNCI: Journal of the National Cancer Institute, Volume 86, Issue 21, 2 November 1994, Page 1653, https://doi.org/10.1093/jnci/86.21.1653 Published: 02 November 1994
Nude Mouse Model of the Melanosis Syndrome&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN4"&gt;4&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1983)

The occurrence of diffuse hyperpigmentation secondary to a xenografted human malignant melanoma was observed in nude mice. The patient from whom this cell line was established developed cutaneous hyperpigmentation after his disease became disseminated. Light and electron microscopy studies were performed on skin and organ biopsy specimens from the hyperpigmented mice. These studies indicated that this melanoma-associated melanosis was secondary to the release of pigment granules from the xenografted tumors and to the uptake of these granules by macrophages throughout the body, including those located in the dermis.
Anisocoria From Scopolamine Patches
Authors: John A. McCrary
Journal: JAMA (1982)

Incidental discovery of a dilated and fixed pupil in a patient with no clinical evidence of impaired oculomotor nerve function or increased intracranial pressure should suggest the diagnosis of pharmacologic dilation of the pupil. The diagnosis can be confirmed without the need for extensive neuroradiological evaluation by instillation of 0.5% to 1.0% pilocarpine hydrochloride in the affected eye. (<i>JAMA</i>1982;248:353-354)
Soviets, Americans Allied in New War; Common Foe This Time: Alcohol Abuse
Authors: Timothy F. Kirn
Journal: JAMA (1987)

AN AMERICAN we will call Ernie, from Akron, Ohio, is sitting at a long table in an official meeting room in Moscow, opposite Soviet government officials and medical researchers. The broad-nosed, square-chinned, former blue-collar worker tells the story of the time a drunk driver hit his car. In the emergency department following the accident, he approached the other driver's wife and said, "I hope I see Bill in an AA [Alcoholics Anonymous] meeting soon." Looking puzzled, he says, she asked, "Who are you?" "I'm the guy in the other car," Ernie says he answered. Explaining his sentiment to the Soviets, Ernie says: "It's terrible when it happens to you, but I couldn't get angry with him. I know what he's going through." Welcome to the first US-Soviet Dialogue on Common Problems, focusing on alcohol problems, and the next to the last day of a two-week exchange program that brought 16
The mutational spectrum of type 1 von Willebrand disease: results from a Canadian cohort study
Authors: P. D. James, C. Notley, C. Hegadorn, J. Leggo, A. Tuttle, S. Tinlin, C. Brown, C. Andrews, A. Labelle, Y. Chirinian, L. O'Brien, M. Othman, G. Rivard, D. Rapson, C. Hough, D. Lillicrap
Journal: Blood (2007)
The Principles of Bacteriology: A Practical Manual for Students and Physicians.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fatal Outcome of Methemoglobinemia in an Infant
Authors: Carl J. Johnson
Journal: JAMA (1987)

CASES of methemoglobinemia in infants and older members of farm families are probably more common than we realize. A 1950 report lists 144 cases of infant methemoglobinemia with 14 deaths in one 30-month period alone in Minnesota.<sup>1</sup>In a 1982 survey of 353 physicians in the ten-county Big Sioux region in eastern South Dakota, 29 physicians reported having treated about 80 cases of methemoglobinemia, of which 64 had occurred more than ten years earlier.<sup>2</sup>All but one case occurred in infants. This preventable, treatable intoxication continues to contribute to infant mortality today. <h3>Report of a Case</h3> A female infant born on April 30, 1986, was breast-fed at first and later received supplementary feedings with a powdered formula mixed with well water. The mother took her to the family physician for a one-month checkup on May 30. At that time, she looked quite healthy, although the mother reported blueness
Interactions of Selenium Deficiency, Vitamin E, Polyunsaturated Fat, and Saturated Fat on Azoxymethane-Induced Colon Carcinogenesis in Male F344 Rats&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1986)

Journal Article Interactions of Selenium Deficiency, Vitamin E, Polyunsaturated Fat, and Saturated Fat on Azoxymethane-Induced Colon Carcinogenesis in Male F344 Rats Get access Bandaru S. Reddy, Bandaru S. Reddy Search for other works by this author on: Oxford Academic PubMed Google Scholar T. Tanaka T. Tanaka Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 76, Issue 6, June 1986, Pages 1157–1162, https://doi.org/10.1093/jnci/76.6.1157 Published: 01 June 1986 Article history Received: 03 May 1985 Revision received: 19 December 1985 Accepted: 21 January 1986 Published: 01 June 1986
Scientific Uncertainties in the Studies of Salicylate Use and Reye's Syndrome
Authors: Stephen R. Daniels
Journal: JAMA (1983)

IN 1963, R. D. K. Reye and coworkers<sup>1</sup>first reported a syndrome of acute encephalopathy associated with the fatty degeneration of the viscera. After almost two decades of research, the etiology of this condition, now designated as "Reye's syndrome," remains obscure. Several recent studies<sup>2-6</sup>have implicated salicylates as a causal factor in Reye's syndrome. Based on these investigations, the Surgeon General of the United States issued an advisory against salicylate use for children with influenza or chickenpox.<sup>7</sup>In addition, the American Public Health Association and the Public Citizen Health Research Group advocated that warning labels should be required on products containing salicylates.<sup>8</sup> A closer examination of the salicylate-Reye's syndrome studies discloses several questions about the validity of these investigations. In reviewing these studies, the Committee on Infectious Diseases of the American Academy of Pediatrics enumerated a number of potential biases that may have occurred in these studies,
Enhancement of Lymphocyte-Mediated Cytotoxicity After Tumor Resection in Patients With Colorectal Cancer&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1980)

Lymphocyte numbers and function in 37 patients with colorectal cancer were compared with those in 23 healthy controls of the same age range. No significant difference in lymphocyte count, numbers of cells forming erythrocyte rosettes or bearing surface immunoglobulin, cell-mediated cytotoxicity, or mitotic response to phytohemagglutinin (PHA) was found. Six to 12 months after tumor resection, patients showed a rise in spontaneous. antibody-induced. and PHA-induced cytotoxicities to levels significantly higher than those found in age-matched controls. This rise occurred irrespective of whether patients had received adjuvant immunotherapy with Corynebacterium parvum.
Highlights of This Issue
Journal: Clinical Cancer Research (2012)

Beji et al. _______________Page 956HER3 receptor tyrosine kinase has been shown to play a crucial role in mediating various human tumors.Beji and colleagues designed a strategy to explore the significance of this pseudokinase in colon cancer.HER3 expression may represent a putative prognostic marker because it correlates with reduced patient survival.Reduction in HER3 expression by either siRNA or monoclonal antibodies abrogated a wide range of cellular processes, including proliferation, migration, and invasion; interfered with progression of the cell cycle; and induced a shift in cell morphology.HER3 may therefore represent a promising target for novel targeted therapy. Keratin Expression in Circulating Tumor Cells Joosse et al. _____________Page 993Circulating tumor cells (CTC) can be detected in peripheral blood of breast cancer patients by antibodies against epithelial-specific keratin proteins.However, during epithelialmesenchymal transition, keratin expression may be downregulated and these CTCs remain undetected.Joosse and colleagues have shown that the keratins currently targeted for CTC detection are downregulated in particular in breast cancer patients with unfavorable outcome.By targeting more keratins, detection of clinically relevant CTCs can be improved, and this information can be used in the future for better assessment of prognosis and monitoring therapeutic efficacy.
Treating the Intoxicated Adolescent
Authors: John N. Stephenson
Journal: JAMA (1984)

Intoxicated adolescents seen in hospital emergency departments are frequently treated for their immediate complaints, but fail to have follow-up assessments for underlying alcohol/drug abuse and/or psychosocial problems. We undertook a prospective study of 171 acutely intoxicated adolescents (12 to 18 years of age) admitted to the emergency department of the University of Wisconsin Hospital and Clinics, Madison. A comparison group randomly selected from the community demonstrated that the emergency department patients were at a significantly higher risk for alcohol and polydrug abuse and psychological dependency. To adequately serve this potentially high-risk group, follow-up assessment must be done, including the gathering of in-depth information regarding legal, psychosocial, and alcohol/drug use status. This study indicates that the general hospital, with its 24-hour emergency department services and other resources, can play a vital role not only in the crisis management of intoxicated adolescents, but in their follow-up, assessment, and, when indicated, appropriate referral for treatment. (<i>JAMA</i>1984;252:1884-1888)
Norms for the Mini-Mental State Examination
Authors: Ralph B. D'Agostino
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Crum et al<sup>1</sup>report age- and education-specific norms on the Mini-Mental State Examination (MMSE)<sup>2</sup>based on a large community sample. Similar data are also available from the Framingham Study that provide further insight into the usefulness of the MMSE. Since 1982 the cohort participating in the Framingham Study has been screened for dementia with the MMSE as part of every biennial medical examination. Individuals suspected of being cognitively impaired have been further evaluated by a neurologist and neuropsychologist. A panel of two neurologists and a neuropsychologist made a final determination about the presence and subtype of dementia. We are able to confirm the age and education association with the MMSE and also address two acknowledged limitations of the study by Crum et al. Since a clinical diagnosis of dementia was made, our data allow us to comment on the performance of individuals with dementia and
Diabetes care needs evidence based interventions to reduce risk of vascular disease
Authors: C. D Byrne
Journal: BMJ (2000)

Asymptomatic haematuria All patients with haematuria should undergo cystoscopyEditor-Having just performed cystoscopy on a man of 36 who presented with bladder cancer five years ago, I am not reassured by Del Mar's so called evidence based survey of the likely diagnoses associated with occult haematuria. 1 The quoted studies are likely to have missed cases of bladder cancer because not all patients underwent cystoscopy.Only 24 of 255 subjects in Ritchie et al's study underwent both upper tract imaging and cystoscopy. 2 Among these, two cases of bladder cancer and one of bladder dysplasia (a premalignant condition) were found.The other 231 patients had not been adequately screened to exclude the presence of bladder cancer.There was no mention of long term follow up to confirm the absence of urological cancer in those who did not undergo initial cystoscopy.Similarly, not all of Hiatt and Ordonez's patients underwent a full urological evaluation, 3 which prompts doubts about the accuracy of the performance statistics quoted in this paper.Sultana et al performed cystoscopy and upper tract imaging in all patients referred over one year with microscopic haematuria. 4 In those aged over 50, five bladder cancers and one renal cancer were diagnosed in 126 patients.More recently Khadra et al performed full urological evaluation of 982 patients with occult haematuria. 5 Altogether 5% had bladder cancer, 4% stone disease, and 0.3% renal cancer.Current urological training emphasises the importance of obtaining a midstream specimen of urine, upper tract imaging, and particularly cystoscopy in all patients who have haematuria, whether microscopic or macroscopic and whether persistent or not.Flexible cystoscopy can now be performed in minutes under local anaesthesia.I believe that there has to be a very good reason for not performing cystoscopy in patients with occult haematuria as this is likely to lead to missed diagnoses of bladder and renal cancer.
Pheochromocytoma Followed Up for 21 Years Without Therapy
Authors: Ronald B. Stein
Journal: JAMA (1971)

Pheochromocytoma and the symptoms produced by excessive catecholamine secretion can usually be cured with surgical excision of the tumor. Very little information is available in the literature regarding the prognosis of medically managed or untreated cases of pheochromocytoma because such tumors are usually surgically removed promptly after the diagnosis is established. A patient with pheochromocytoma, described in this report, refused surgery and was followed up for 21 years without significant treatment until death occurred during a hypertensive crisis.
Aids to Anatomy (Pocket Anatomy)
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gonorrhea Detection in Posthysterectomy Patients
Authors: Barbara D. Klaus
Journal: JAMA (1978)

A retrospective study of women examined at the Venereal Disease Clinic after hysterectomy was made to determine which culture site was most likely to show anogenital<i>Neisseria gonorrhoeae</i>infection when the cervix was absent. Seventeen of 104 such patients were culture positive for<i>N gonorrhoeae</i>. Rates of positivity for our culture sites were as follows: urethral, 17/17 (100%); vaginal, 7/17 (41%); and rectal, 2/17 (12%). (<i>JAMA</i>240:1360-1361, 1978)
Endoscopy International Open – recently published
Journal: Endoscopy (2015)

See also: Tissue shielding with polyglycolic acid sheets and fibrin glue on ulcers induced by endoscopic submucosal dissection in a porcine modelEndosc Int Open 2015; 03(02): E146-E151DOI: 10.1055/s-0034-1391391 See also: The addition of high magnifying endoscopy improves rates of high confidence optical diagnosis of colorectal polypsEndosc Int Open 2015; 03(02): E140-E145DOI: 10.1055/s-0034-1391362 See also: Interobserver agreement of contrast-enhanced harmonic endoscopic ultrasonography in the evaluation of solid pancreatic lesionsEndosc Int Open 2015; 3(03): E205-E209DOI: 10.1055/s-0034-1391415
Expression of YBB 3/10 Antigen in Human Tumor Colon Cell Lines and Its Induction by &lt;italic&gt;N,N&lt;/italic&gt;-Dimethylformamide&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1985)

Journal Article Expression of YBB 3/10 Antigen in Human Tumor Colon Cell Lines and Its Induction by N,N-Dimethylformamide Get access Andrea Quaroni Andrea Quaroni Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 74, Issue 3, March 1985, Pages 591–602, https://doi.org/10.1093/jnci/74.3.591 Published: 01 March 1985 Article history Received: 05 September 1984 Accepted: 23 October 1984 Published: 01 March 1985
AMERICAN MEDICAL LITERATURE.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal