Abstract 6468: Association of food groups and dietary pattern with breast cancer risk: A systematic review and meta-analysis
Authors: Jialei Fu, Woo-Kyoung Shin, Dan Huang, Sukhong Min, Li-Juan Tan, Hyein Jung, Khongorzul Ganbat, Jiwon Jeong, Seok-Jae Oh, Bayarmaa Nasan Ulzii, Daehee Kang, Sangah Shin
Journal: Cancer Research (2023)

Abstract We conducted a systematic review and meta-analysis of current evidence for the association between food groups, dietary patterns, and breast cancer risk among the Asian population. This systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. We performed a systematic literature search up to November 2022 in English in the PubMed, Web of Science, Embase, and Cochrane databases. Risk ratios (RRs) with 95% confidence intervals (CIs) were extracted as effect sizes. Publication bias was estimated by the funnel plot method. We collected the data from 15 cohort studies and 30 case-control studies meeting the search criteria. The meta-analysis found that fruit and vegetable consumption was associated with a 27% and 35% lower risk of breast cancer, respectively [RR = 0.73 (0.56, 0.96); RR = 0.65 (0.47, 0.90)]. By contrast, no significance was found between meat, soy food, and green tea consumption and breast cancer risk (P &amp;gt; 0.05). However, soy protein and isoflavone intake could lower breast cancer risk by 35% and 32%, respectively [RR = 0.65 (0.51, 0.83); RR = 0.68 (0.55, 0.82)]. As for dietary pattern, higher adherence to a healthy dietary pattern and healthy eating index was associated with a 38% and 62% reduction in breast cancer risk, respectively [RR = 0.62 (0.44, 0.88; RR = 0.38 (0.22, 0.67)], while high adherence to an unhealthy dietary pattern was associated with a 44% increased risk [RR = 1.44 (1.06, 1.96)]. Considering alcohol consumption, a 75% increased risk of breast cancer was found [RR= 1.75 (1.33, 2.30)]. The present meta-analysis found that high intakes of fruit, vegetable, soy protein, and soy isoflavone significantly reduced the risk of breast cancer, while high intake of alcohol had a significantly increased risk. Meat, soy food, and green tea consumption were not significantly associated with breast cancer risk. Considering dietary patterns, higher adherence to a healthy eating index and a healthy dietary pattern may reduce breast cancer risk. Conversely, adherence to unhealthy dietary patterns may increase breast cancer risk. However, further studies are needed to confirm the associations between dietary patterns and breast cancer in the Asian population. This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No.2022R1F1A1074279). MSIT: Ministry of Science and ICT. Citation Format: Jialei Fu, Woo-Kyoung Shin, Dan Huang, Sukhong Min, Li-Juan Tan, Hyein Jung, Khongorzul Ganbat, Jiwon Jeong, Seok-Jae Oh, Bayarmaa Nasan Ulzii, Daehee Kang, Sangah Shin. Association of food groups and dietary pattern with breast cancer risk: A systematic review and meta-analysis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6468.