tbuckley/cabot-search huggingface dataset:
SURGEONS APPRECIATED.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Third Conference on Water Chlorination: Environmental Impact and Health Effects
Journal: JNCI Journal of the National Cancer Institute (1979)

Third Conference on Water Chlorination: Environmental Impact and Health Effects Get access JNCI: Journal of the National Cancer Institute, Volume 62, Issue 5, May 1979, Page 1319, https://doi.org/10.1093/jnci/62.5.1319-c Published: 01 May 1979
Medium isn't accurate 'Ice Age' message
Authors: P. Cotton
Journal: JAMA (1990)

HYPE IS A WEAPON that may backfire in the war on drugs. The advent of Ice, a smokable, crystal form of d-methamphetamine hydrochloride, could prove as much, say some researchers. "My cocaine smoking subjects are very interested" in Ice, which is being "beautifully advertised by the media," says Marian Fischman, PhD, associate professor of psychiatry at The Johns Hopkins Medical Institutions. "The message sent and the message received are not always the same," stresses Donald Wesson, MD, associate clinical professor of psychiatry at the University of California at San Francisco. Both spoke at a symposium on "Anticipating the New Ice Age." Ice leads drug-related arrests in Hawaii, causing 20% more than cocaine, according to the Honolulu police department. The University of Michigan annual survey of high school seniors found a 1.2% use rate nationwide, 3% in the West, and slightly higher rates among 19-to 28-year-olds. The appeal of Ice to
<i>Erratum</i>: Vol. 66, No. 29
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

In the report "Outbreak of Septic Arthritis Associated with Intra-Articular Injections at an Outpatient Practice -New Jersey, 2017," the type of container was misstated.The container should have been described as a single-dose container instead of a pharmacy bulk packaged (PBP) product.Singledose containers can only be repackaged for multiple patients by qualified health care personnel in accordance with standards in United States Pharmacopeia General Chapter <797> Pharmaceutical Compounding -Sterile Preparations.
From the Centers for Disease Control. Progress toward achieving the 1990 high blood pressure objectives
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Basal nitric oxide synthesis in coronary stenoses: Relation to morphology, Length, Severity Dimitris Tousoulis, Costas Tentolouris, George S. Goumas, Costas Xenakis, Tom Crake, Costas Toutouzas, Aris Androulakis, Christodoulos Stefanadis, Graham Davies, Pavlos Toutouzas. Hippokration Hospital, Athens, Greece, Hammersmith Hospital, London, United Kingdom
Journal: Journal of the American College of Cardiology (2001)
Abstract P238: Culturally-Competent Heart Health Coaching Improves Lipids in South Asians
Authors: Powell O Jose, Kristin M Azar, Jennifer Kang, Marshall Baek, Latha P Palaniappan, Anita Sathe, Donna Malhotra, Jeannette Kotrys, Vijaya Deo, Shraddha Patel, Ashish Mathur, Cesar Molina
Journal: Circulation (2013)

Background: Health coaching programs, delivered by trained non-medical and medical personnel, and focused on diet and lifestyle counseling, have proven beneficial in both primary and secondary prevention of cardiovascular disease. These coaching programs, however, have not been tested or validated in South Asians, who have unique dietary and lifestyle habits, and greatly increased risk of coronary artery disease. Methods: We examined lipid values in participants who were invited to enroll in the Heart Health Coaching Program at the South Asian Heart Center at El Camino Hospital in Mountain View, California. Trained volunteer coaches contacted interested participants throughout the year by phone and email to deliver culturally-competent health education on diet, physical activity, and stress reduction. Participants were categorized, based on their level of participation, into three groups: those who did not enroll in the coaching program (non-coached, N=33), those who received some coaching (partially coached, N=145), and those who completed one full year of the program (fully coached, N=558). Fasting lipid measurements were obtained with mean differences being calculated from their baseline and last available follow-up lab test. Paired t-test was used for comparison of baseline and follow-up lab tests within each group. Multivariate age-adjusted analyses incorporated MANOVA to detect for differences between groups. Results: There were no significant differences in mean age(43, 42 and 43), mean BMI(25.8, 26.5 and 26.2), or baseline lipid values across the three groups (fully-coached, partially coached, and non-coached respectively). There were significant improvements in total cholesterol(TC) (-5.5±28.4mg/dl), LDL(-4.1±24.3), HDL (1.9±6.4), triglycerides(-16.1±67.3), and TC/HDL ratio(-0.31±0.83) in the fully coached group (p&lt;0.001 for all). The partially coached group demonstrated reductions in total cholesterol(-5.2±27.8, p=0.03), LDL(-8.1±28.0mg/dl, p&lt;0.001), and TC/HDL ratio (-0.42±1.01, p&lt;0.001) with a trend towards increased HDL (4.9±31.3, p=0.06). Non-coached participants did not have any statistically significant differences for any lipid measurement. Coached participants were more likely to improve lipid values than partially coached and non-coached participants (p&lt;0.001). Conclusions: Our results suggest the benefit of a volunteer culturally-competent coaching program for South Asians in improving their lipid profile. Benefit was obtained even for partially coached participants. Non-medically trained health coaches may be an effective method to deliver culturally appropriate cardiovascular health messages for South Asians at risk for developing coronary artery disease.
Canker Sores
Authors: Louis Tuft
Journal: JAMA (1961)

<h3>To the Editor:—</h3> In the Nov. 5, 1960, issue ofThe Journal, page 1360, in the Correspondence Section, Dr. Rosenbaum of Cleveland Heights, Ohio, mentions the relief of annoying recurrent canker sores (aphthous stomatitis) which followed his avoidance of such foods as chocolates, potato chips, and salted nuts. Neither he nor the consultant, Dr. White, was able to account for the beneficial effect of the elimination of these foods from Dr. Rosenbaum's diet. Dr. White mentioned the frequently accused but unproven viral etiology, despite much recent evidence disproving this idea. We would like to call the attention of both these writers to our own studies, "Canker Sores from Allergy to Weak Organic Acids (Citric and Acetic)" (Tuft, L., and Ettelson, L. N.:<i>J Allergy</i><b>27</b>:536-546 [Nov.] 1956) and "Buccal Mucosal Tests in Patients with Canker Sores (Aphthous Stomatitis)" (Tuft, L., and Girsh, L. S.:<i>J Allergy</i><b>29</b>:502-510 [Nov.-Dec.]
THE SURVIVAL OF THE FITTEST
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inhibition of cell growth in human glioblastoma cell lines by farnesyltransferase inhibitor SCH66336
Authors: Tricia L. Glass, Ta-Jen Liu, W.K. Alfred Yung
Journal: Neuro-Oncology (2000)

Ras activation occurs through stimulation of an upstream growth factor receptor such as epidermal growth factor receptor (EGFR). The ultimate effect ofRas is to induce nuclear transcription via a signaling pathway sequentially involving Raf, MAP kinase kinase (MEK), and mitogenactivated protein kinase (MAPK).To transform cells, Ras oncoproteins must be posttranslationally modi ed with a farnesyl group in a reaction catalyzed by farnesyl protein transferase.Farnesyltransferase inhibitors, therefore, have been proposed as potent anticancer agents.This study demonstrates the growth-inhibitory effects of farnesyltransferase inhibitor SCH66336 on human glioblastoma cell lines U-251 MG, U-251/E4 MG (a stably transfected cell line with elevated EGFR expression), and U-87 MG.As determined by (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl-2-(4-sulfophenyl)-2H-tetraz olium, inner salt) (MTS) and viability assays, the concentration required to achieve 50% inhibition (IC 50 ) ranged from 30 µM (single 24-h treatment) to 10 µM (5-day treatment).U-251/E4 MG with overexpression of EGFR were more sensitive than U-251 MG parental cells.These observations were also supported by soft agar analysis.Cells treated with SCH66336 underwent G2 arrest.Western blot analysis revealed a decrease in phospho-MAPK levels upon treatment with 10 µM SCH66336, whereas MAPK levels were unaffected by the drug.Interestingly, increased expression of EGFR was observed in U-251 MG and U-251/E4 MG but not in U-87 MG in the presence of the inhibitor.These results demonstrate that SCH66336 inhibits viability and anchorage-independent growth in a time-and dosedependent manner in glioblastoma cell lines U-251 MG, U-251/E4 MG, and U-87 MG via a signal transduction pathway involving the down-regulation of phospho-MAPK.Overexpression of EGFR appears to alter cellular sensitivity to farnesyltransferase inhibitors.This may have a particularly important implication in glioblastoma, where over 50% of tumors have ampli cation and overexpression of EGFR.
Topical anaesthesia in upper gastrointestinal endoscopy.
Journal: BMJ (1991)

Most upper gastrointestinal endoscopy in Britain is performed in sedated patients' and the need for topical pharyngeal anaesthesia is not established-some studies showing benefit,2 others not.3 'This uncertainty is reflected in clinical practice, a recent postal survey showing that 63% of endoscopists use pharyngeal anaesthesia regularly, 20% not at all, and the rest sometimes.'We have tested the value of pharyngeal anaesthesia in a double blind placebo controlled study in patients sedated with intravenous midazolam having upper gastrointestinal endoscopy.
Normal Growth and Development during Adolescence
Authors: Harold C. Stuart
Journal: New England Journal of Medicine (1946)

Adolescent Changes in Physiologic Functions Basal Metabolism There is of course an increase in the number of basal calories consumed per hour by the body as it increases in size year by year, and this is greater during pubescence than previously because the body size is increasing more rapidly. There is, however, less clear evidence regarding any fundamental increase in the basal metabolic rate associated with pubescence that is not explained on the basis of increased amount of active protoplasmic tissue.In a comprehensive study of basal metabolism in girls, Talbot, Wilson and Worcester45 in 1937 investigated the effects of . . .
On the Consequences of Model Misspecification in Logistic Regression
Authors: Melissa Dowd Begg, Stephen Lagakos
Journal: Environmental Health Perspectives (1990)

Logistic regression models are commonly used to study the association between a binary response variable and an exposure variable. Besides the exposure of interest, other covariates are frequently included in the fitted model in order to control for their effects on outcome. Unfortunately, misspecification of the main exposure variable and the other covariates is not uncommon, and this can adversely affect tests of the association between the exposure and response. We allow the term "misspecification" to cover a broad range of modeling errors including measurement errors, discretizing continuous explanatory variables, and completely excluding covariates from the model. This paper reviews some recent results on the consequences of model misspecification on the large sample properties of likelihood score tests of association between exposure and response.
More on Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke
Authors: Craig S Anderson, Mark Woodward, John Chalmers
Journal: New England Journal of Medicine (2018)

ing noncompetitive sports.Our registry of all cardiac arrests included every record of persons with an event for which EMS were activated. 5In Canada, it would be highly unlikely that EMS would not be activated for a person younger than 45 years with sudden cardiac arrest.We agree with Pressler that large, prospective studies are warranted.On the basis of our findings and those of others, 4 5 million athletes would need to undergo preparticipation screening to identify 38 sudden cardiac arrests per year.Since most sudden cardiac arrests occur at rest, 1 a study to conclusively show a reduction in sudden cardiac arrests as a result of screening would be an extraordinary challenge.We limited our study to competitive athletes younger than 45 years of age.We agree with Burtscher that the risk of sudden cardiac arrest associated with coronary disease increases with age.
JAMA Pediatrics
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Shannon Sparenga, Nicole Balin, Miriam Cintron, Paul Ruich, Diane Cannon, Connie Manno, Fred Marshall, Laura Copyreaders, Catherine Adamcyzk, Jan Alden, Mary Clavey, Gillian Coerver-Connolly, Laura Dickens, Juliann King, Donna Tarsney, Caroline Thordsen, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Williams, Lenette Gardner-Gullens, Fanny Brown, Paul Frank, Rachell Lozano, Michaela Mark, Kathryn Muskovich, J Neff, Kate Pezalla, Gale Saulsberry, Michael Berkwits, Michelle Kurzynski, Eric Butkus, Christopher Hastings, Craig Mccaffrey, Reuben Rios, Ronna Henry, Joshua Bird, Alison Burke, Cassio Lynm, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Deanna Bellandi, Jim Periodical, Thomas Staff, Monica Smith, Jeffery Bonistalli Manager, Kathy Russell, Mirna Monal, Tim Melroy, Thalia Moss, Susan Henning, Mark Thornbury, Tricia Castellano, Saskia Bolore, Gretchen Linder, Brian Mccartney, David Baum, Rebecca Haas, Christine Hearne, Irma Lara, Audra Lawlor, Matt Herron, Elizabeth Solaro, Geoffrey Flick, Paul Gee Managers, Rick Bell, Michael Mcgraw, Sara Nagy, Stacy Staff, Millette Jackson-Bates, Karen Adams-Taylor, Karl Elvin, Sue Sherrill, Brian Shields Managers, David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Diane Darnell, Colleen Kelly, Chris Meyer, Jaye Mize, Annemarie Neff, Sean O'donnell, Sean Ohlson, Phil O'leary, Susan Price, Denise Steinhauser, Production Services, Kim Boler, Rhonda Brown, Timothy Burke, Daniel Degroot, Jordynn Farrar, Euwanaha Joiner-Smith, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Dexter Golden, Erin Hinchcliff, Noemi Rivera, Geneine Van Someren, New Media, Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Scott Curl, Amy Evers, Teri Hutchison, Mary Kuranda, Joshua Lampinen, Patricia Panek, La Son, Diggs Sledge, George Thomson, Amanda Graphics, Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Daniel James, Judith Literskis, Teresa Omiotek, James Madara, Bernard Hengesbaugh, Dimitri Christakis, Washington Joffe, Ron Keren, Suzanne Shuey, Benjamin French, Peter Cummings, Samir Shah, Howard Bauchner, Frederick Rivara, Joyce Lee, Ann Arbor, Cherrie Boyer, San Francisco, Robert Bradley, Maria Britto, John Campo, Aaron Carroll, Indiana Frank, Joseph Chaloupka, Mitchell Cohen, Chris Feudtner, Kathleen Janz, Iowa City, Terry Klassen, Michigan Michelle, Huckaby Lewis, Maryland Saiman, New York, York Samir, Martha Sola-Visner, Jean-Claude Carel, Shabir Madhi, Ben Marais, Frank Oberklaid, Susan Sawyer, Joan-Carles Surís
Journal: JAMA Pediatrics (2014)
Withdrawing payment for nonscientific drug therapy. Intended and unexpected effects of a large-scale natural experiment
Authors: S. B. Soumerai
Journal: JAMA (1990)

Little is known about the effect on clinical decision making of nonreimbursement for ineffective medical technologies. Using a time-series design, we studied the effects of cessation of government payment for 12 categories of drugs of questionable efficacy (Drug Efficacy Study Implementation drugs) in a random sample of the New Jersey Medicaid population (N = 390 465) and in four cohorts of regular users of these products. We measured changes in the overall levels of prescriptions, expenditures, and physicians' use of substitute drugs. Although withdrawn drugs accounted for 7% of prescriptions in the base year, there was no measurable reduction in overall drug use or expenditures after the regulation; prescription rates actually rose from 0.86 to 1.00 monthly prescriptions per enrollee throughout the 42-month study. Controlling for preexisting trends, an estimated drop in the use of study drugs of 21.7 prescriptions per 1000 enrollees per month was offset by an increase in the use of substitute drugs of 33.7 prescriptions. Both desirable and unimproved therapeutic substitutions were observed. Used alone, curtailment of reimbursement for marginally effective therapies results in both desirable and unintended clinical substitutions and may not reduce costs. Supplementing such restrictions with education may be necessary to promote practices that are more therapeutically and economically appropriate. (<i>JAMA</i>. 1990;263:831-839)
National Epidemiology
Authors: P. W. Bothwell
Journal: BMJ (1961)

There is poor agreement on definitions of different phenotypes of preschool wheezing disorders. The present Task Force proposes to use the terms episodic (viral) wheeze to describe children who wheeze intermittently and are well between episodes, and multiple-trigger wheeze for children who wheeze both during and outside discrete episodes. Investigations are only needed when in doubt about the diagnosis. Based on the limited evidence available, inhaled short-acting β<sub>2</sub>-agonists by metered-dose inhaler/spacer combination are recommended for symptomatic relief. Educating parents regarding causative factors and treatment is useful. Exposure to tobacco smoke should be avoided; allergen avoidance may be considered when sensitisation has been established. Maintenance treatment with inhaled corticosteroids is recommended for multiple-trigger wheeze; benefits are often small. Montelukast is recommended for the treatment of episodic (viral) wheeze and can be started when symptoms of a viral cold develop. Given the large overlap in phenotypes, and the fact that patients can move from one phenotype to another, inhaled corticosteroids and montelukast may be considered on a trial basis in almost any preschool child with recurrent wheeze, but should be discontinued if there is no clear clinical benefit. Large well-designed randomised controlled trials with clear descriptions of patients are needed to improve the present recommendations on the treatment of these common syndromes.
THE DEATH OF BROWN-SEQUARD.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal