tbuckley/cabot-search huggingface dataset:
Coronary In-Stent Restenosis
Authors: Gennaro Giustino, Antonio Colombo, Anton Camaj, Keisuke Yasumura, Roxana Mehran, Gregg W. Stone, Annapoorna Kini, Samin K. Sharma
Journal: Journal of the American College of Cardiology (2022)

The introduction and subsequent iterations of drug-eluting stent technologies have substantially improved the efficacy and safety of percutaneous coronary interventions. However, the incidence of in-stent restenosis (ISR) and the resultant need for repeated revascularization still occur at a rate of 1%-2% per year. Given that millions of drug-eluting stents are implanted each year around the globe, ISR can be considered as a pathologic entity of public health significance. The mechanisms of ISR are multifactorial. Since the first description of the angiographic patterns of ISR, the advent of intracoronary imaging has further elucidated the mechanisms and patterns of ISR. The armamentarium and treatment strategies of ISR have also evolved over time. Currently, an individualized approach using intracoronary imaging to characterize the underlying substrate of ISR is recommended. In this paper, we comprehensively reviewed the incidence, mechanisms, and imaging characterization of ISR and propose a contemporary treatment algorithm.
Healing Water
Authors: Jack Coulehan
Journal: Annals of Internal Medicine (2022)

Ad LibitumJuly 2022Healing WaterJack Coulehan, MD, MPHJack Coulehan, MD, MPHCenter for Medical Humanities, Compassionate Care, and Bioethics at Stony Brook University Stony Brook, New YorkSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M21-3922 Audio Reading - “Healing Water” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Healing Water” by Jack Coulehan, MD, MPH Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Let ... Author, Article, and Disclosure InformationAffiliations: Center for Medical Humanities, Compassionate Care, and Bioethics at Stony Brook University Stony Brook, New YorkCorresponding Author: Jack Coulehan, MD, MPH; e-mail, john.[email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “Healing Water” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Healing Water” by Jack Coulehan, MD, MPH Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics July 2022Volume 175, Issue 7Page: 1056 ePublished: 19 July 2022 Issue Published: July 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Ceria nanoparticles prophylactic used for renal ischemia-reperfusion injury treatment by attenuating oxidative stress and inflammatory response
Authors: Lan Zhou, Shupei Tang, Fang Li, Yonghui Wu, Sirui Li, Liwei Cui, Jing Luo, Lu Yang, Zhicheng Ren, Ji Zhang, Denglu Zhou, Jun Jiang, Xiaochao Yang, Xinyuan Zhou, Yuzhang Wu
Journal: Biomaterials (2022)
What babies need: accelerating access to current and novel antiretroviral drugs in neonates through pharmacokinetic studies
Authors: Tom G Jacobs, Stef Schouwenburg, Martina Penazzato, Moherndran Archary, Theodore D Ruel, John van den Anker, David M Burger, Tim R Cressey, Elaine J Abrams, Hermione Lyall, Adrie Bekker, Angela Colbers, David Burger, Adrie Bekker, Tim Cressey, Deborah Hirt, Irja Lutsar, Helen Mcilleron, Joe Standing, John Van den Anker, Elin Svensson, Elaine Abrams, Pauline Amuge, Mo Archary, Adrie Bekker, Yodit Belew, Brookie Best, David Burger, Helen Bygrave, Edmund Capparelli, Esther Casas, Diana Clarke, Polly Clayden, Angela Colbers, Tim Cressey, Mutsa Dangarembizi, Roberto De Lisa, Paolo Denti, Paul Domanico, Shaffiq Essajee, Lisa Frigati, Carlo Giaquinto, Diana Gibb, Stephanie Hackett, Rohan Hazra, Marc Lallemant, Linda Lewis, Shahin Lockman, Imelda Mahaka, Betsy McFarland, Cathal Meere, Fatima Mir, Mark Mirochnick, Lynne Mofenson, Irene Mukui, Angela Mushavi, Victor Musiime, Eleanor Namusoke-Magongo, Elisabeth Obimbo, Mary Atieno Ojoo, Roger Parades, Carmen Perez-Casas, Manuele Piccolis, Jorge Pinto, Thanyawee Puthanakit, Natella Rakhmanina, Annette Reinisch, Pablo Rojo, Vanessa Rouzier, Ted Ruel, Nadia Sam-Agudu, George Siberry, Teresa Simione, Katie Simon, Vindi Singh, Manjari Solares, Nandita Sugandhi, Mariam Sylla, Ibou Thior, Anna Turkova, Marissa Vicari, Jenny Walsh, Melynda Watkins, Hilary Wolf, Asma Hafiz, Martina Penazzato, Ajay Rangaraj, Meg Doherty, Marco Vitoria
Journal: The Lancet HIV (2022)
Microfluidic chemostatic bioreactor for high-throughput screening and sustainable co-harvesting of biomass and biodiesel in microalgae
Authors: Guoxia Zheng, Yutong Cui, Ling Lu, Ming Guo, Xuejun Hu, Lin Wang, Shuping Yu, Shenxia Sun, Yuancheng Li, Xingcai Zhang, Yunhua Wang
Journal: Bioactive Materials (2022)

As a renewable and sustainable source for energy, environment, and biomedical applications, microalgae and microalgal biodiesel have attracted great attention. However, their applications are confined due to the cost-efficiency of microalgal mass production. One-step strategy and continuous culturing systems could be solutions. However, current studies for optimization throughout microalgae-based biofuel production pipelines are generally derived from the batch culture process. Better tools are needed to study algal growth kinetics in continuous systems. A microfluidic chemostatic bioreactor was presented here, providing low-bioadhesive cultivations for algae in a cooperative environment of gas, nutrition, and temperature (GNT) involved with high throughput. The chip was used to mimic the continuous culture environment of bioreactors. It allowed simultaneously studying of 8 × 8 different chemostatic conditions on algal growth and oil production in parallel on a 7 × 7 cm2 footprint. On-chip experiments of batch and continuous cultures of Chlorella. sp. were performed to study growth and lipid accumulation under different nitrogen concentrations. The results demonstrated that microalgal cultures can be regulated to grow and accumulate lipids concurrently, thus enhancing lipid productivity in one step. The developed on-chip culturing condition screening, which was more suitable for continuous bioreactor, was achieved at a half shorter time, 64-times higher throughput, and less reagent consumption. It could be used to establish chemostat cultures in continuous bioreactors which can dramatically accelerate the development of renewable and sustainable algal for CO2 fixation and biosynthesis and related systems for advanced sustainable energy, food, pharmacy, and agriculture with enormous social and ecological benefits.
Photo-enhanced upcycling H2O2 into hydroxyl radicals by IR780-embedded Fe3O4@MIL-100 for intense nanocatalytic tumor therapy
Authors: Ju-E Cun, Yang Pan, Zhuangzhuang Zhang, Yao Lu, Junhua Li, Qingqing Pan, Wenxia Gao, Kui Luo, Bin He, Yuji Pu
Journal: Biomaterials (2022)
A Legacy of Scientific Racism
Authors: Mohammed A. Nurhussein
Journal: Annals of Internal Medicine (2022)

LettersJuly 2022A Legacy of Scientific RacismMohammed A. Nurhussein, MDMohammed A. Nurhussein, MDSUNY Downstate, Brooklyn, New YorkSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L22-0136 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR: Bryan and colleagues' article on systemic racism offers a welcome and timely focus on the role that some of our iconic leaders played—perhaps fortuitously—in the creation and perpetuation of structural racism in medicine. In the pantheon of these luminaries, no one shines brighter than William Osler, a brilliant clinician, widely admired educator, and prolific writer whose influence on the practice of medicine endures to this day. He is deservedly dubbed the “Father of Modern Medicine” and revered on both sides of the Atlantic. In his address to the British Medical Association in 1897, he stated, “Distinctions of ...References1. Bryan CS, deShazo RD, Balch MW. A legacy of scientific racism: William Osler's “An Alabama Student.” Ann Intern Med. 2022;175:114-8. [PMID: 35038401] doi:10.7326/M21-3474 LinkGoogle Scholar2. Persaud N, Butts H, Berger P. William Osler: saint in a “White man's dominion.” CMAJ. 2020;192:E1414-6. [PMID: 33168766] doi:10.1503/cmaj.201567 CrossrefMedlineGoogle Scholar3. Dickinson College. Benjamin Rush, race, slavery, and abolitionism. 2011. Accessed at www.dickinson.edu/info/20043/about/3480/benjamin_rush on 21 March 2022. Google Scholar4. Burnett-Bowie SAM, Bachmann GA. Racism: the shameful practices that the medical profession is finally addressing. Womens Midlife Health. 2021;7. doi.10.1186/s40695-021-00068-1 Google Scholar Author, Article, and Disclosure InformationAffiliations: SUNY Downstate, Brooklyn, New YorkDisclosures: Authors have reported no disclosures of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L22-0136. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA Legacy of Scientific Racism: William Osler's “An Alabama Student” Charles S. Bryan , Richard D. deShazo , and Margaret W. Balch A Legacy of Scientific Racism Charles S. Bryan and Richard D. deShazo Metrics July 2022Volume 175, Issue 7Page: W69KeywordsArchivesLibrariesRacial and ethnic issuesRiversSurgeons ePublished: 19 July 2022 Issue Published: July 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis
Authors: Faisel Khan, Isabel Gonçalves, Angela C. Shore, Andrea Natali, Carlo Palombo, Helen M. Colhoun, Gerd Östling, Francesco Casanova, Cecilia Kennbäck, Kunihiko Aizawa, Margaretha Persson, Kim M. Gooding, David Strain, Helen Looker, Fiona Dove, Jill Belch, Silvia Pinnola, Elena Venturi, Michaela Kozakova, Jan Nilsson
Journal: Cell Reports Medicine (2022)

The factors that influence the atherosclerotic disease process in high-risk individuals remain poorly understood. Here, we used a combination of vascular imaging, risk factor assessment, and biomarkers to identify factors associated with 3-year change in carotid disease severity in a cohort of high-risk subjects treated with preventive therapy (n = 865). The results show that changes in intima-media thickness (IMT) are most pronounced in the carotid bulb. Progression of bulb IMT demonstrates independent associations with baseline bulb IMT, the plaque gray scale median (GSM), and the plasma level of platelet-derived growth factor (PDGF) (standardized β-coefficients and 95% confidence interval [CI] −0.14 [−0.06 to −0.02] p = 0.001, 0.15 [0.02–0.07] p = 0.001, and 0.20 [0.03–0.07] p < 0.001, respectively). Plasma PDGF correlates with the plaque GSM (0.23 [0.15–0.29] p < 0.001). These observations provide insight into the atherosclerotic process in high-risk subjects by showing that progression primarily occurs in fibrotic plaques and is associated with increased levels of PDGF.
Annals Consult Guys - Portal Vein Thrombosis: What Could Be the Cause?
Authors: Howard H. Weitz, Geno J. Merli
Journal: Annals of Internal Medicine (2022)

Web ExclusivesJuly 2022Annals Consult Guys - Portal Vein Thrombosis: What Could Be the Cause?FREEHoward H. Weitz, MD and Geno J. Merli, MDHoward H. Weitz, MDThomas Jefferson University, Philadelphia, Pennsylvania (H.H.W., G.J.M.)Search for more papers by this author and Geno J. Merli, MDThomas Jefferson University, Philadelphia, Pennsylvania (H.H.W., G.J.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W21-0008 CME/MOC SectionsSupplemental MaterialAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The Annals Consult Guys discuss the evaluation of a patient with portal vein thrombosis and work through evaluation of the cause of the thrombosis and its appropriate treatment.For more videos from and information on Annals Consult Guys, visit go.annals.org/ConsultGuys. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Thomas Jefferson University, Philadelphia, Pennsylvania (H.H.W., G.J.M.)Disclosures: Drs. Merli and Weitz report that they have no financial relationships or interests to disclose. All relevant financial relationships have been mitigated. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=W21-0008.Editors' Disclosures: Christine Laine, MD, MPH, Editor in Chief, reports that her spouse has stock options/holdings with Targeted Diagnostics and Therapeutics. Stephanie Chang, MD, MPH, Deputy Editor, reports employment with the Agency for Healthcare Research and Quality, travel compensation from the Guidelines International Network, and participation in the Patient-Centered Outcomes Research Institute methodology committee. Vineet Chopra, MD, MSc, Deputy Editor, reports grants received from the Agency for Healthcare Research and Quality and royalties from UpToDate and Oxford University Press. Deborah Cotton, MD, MPH, Deputy Editor, reports that she has no financial relationships or interests to disclose. Eliseo Guallar, MD, MPH, DrPH, Deputy Editor, Statistics, reports that he is employed at Johns Hopkins University. Christina C. Wee, MD, MPH, Deputy Editor, reports employment with Beth Israel Deaconess Medical Center and consultancy with Boston Medical Center. Sankey V. Williams, MD, Deputy Editor, reports that he has no financial relationships or interests to disclose. Yu-Xiao Yang, MD, MSCE, Deputy Editor, reports employment with the Perelman School of Medicine, University of Pennsylvania, and consultancies with the U.S. Food and Drug Administration and the State of Colorado. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics July 2022Volume 175, Issue 7Page: CG1 ePublished: 19 July 2022 Issue Published: July 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.Loading ...
BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma
Authors: Ellen Weisberg, Basudev Chowdhury, Chengcheng Meng, Abigail E. Case, Wei Ni, Swati Garg, Martin Sattler, Abdel Kareem Azab, Jennifer Sun, Barbara Muz, Dana Sanchez, Anthia Toure, Richard M. Stone, Ilene Galinsky, Eric Winer, Scott Gleim, Sofia Gkountela, Alexia Kedves, Edmund Harrington, Tinya Abrams, Thomas Zoller, Andrea Vaupel, Paul Manley, Michael Faller, BoYee Chung, Xin Chen, Philipp Busenhart, Christine Stephan, Keith Calkins, Debora Bonenfant, Claudio R. Thoma, William Forrester, James D. Griffin
Journal: Blood Cancer Journal (2022)

Bromodomain-containing protein 9 (BRD9), an essential component of the SWI/SNF chromatin remodeling complex termed ncBAF, has been established as a therapeutic target in a subset of sarcomas and leukemias. Here, we used novel small molecule inhibitors and degraders along with RNA interference to assess the dependency on BRD9 in the context of diverse hematological malignancies, including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and multiple myeloma (MM) model systems. Following depletion of BRD9 protein, AML cells undergo terminal differentiation, whereas apoptosis was more prominent in ALL and MM. RNA-seq analysis of acute leukemia and MM cells revealed both unique and common signaling pathways affected by BRD9 degradation, with common pathways including those associated with regulation of inflammation, cell adhesion, DNA repair and cell cycle progression. Degradation of BRD9 potentiated the effects of several chemotherapeutic agents and targeted therapies against AML, ALL, and MM. Our findings support further development of therapeutic targeting of BRD9, alone or combined with other agents, as a novel strategy for acute leukemias and MM.
Leave My Soul Alone!
Authors: Jack Coulehan
Journal: Annals of Internal Medicine (2022)

Ad LibitumJuly 2022Leave My Soul Alone!Jack Coulehan, MD, MPHJack Coulehan, MD, MPHCenter for Medical Humanities, Compassionate Care, and Bioethics at Stony Brook University Stony Brook, New YorkSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M21-3921 Audio Reading - “Leave My Soul Alone!” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Leave My Soul Alone!” by Jack Coulehan, MD, MPH Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail For Dr. Dannie AbseIn your poem, a surgeonplaced a probe into his patient's brainto ascertain the tumor's marginbut touched instead a forbidden zoneand caused a frigid voice to cry,Leave my soul alone!A nucleus, a metal probe,a cause of unexpected anguish.How could that surgeon have knownwhat his probe might pierce and makethe impossible speak? I've sentless rigid probes—words, stories, skin—to touchthat source, sometimes achieved successand sometimes pain. My loneliness,whether it lives within the brainor not, demands response. I cannotleave the soul alone. Author, Article, and Disclosure InformationAffiliations: Center for Medical Humanities, Compassionate Care, and Bioethics at Stony Brook University Stony Brook, New YorkCorresponding Author: Jack Coulehan, MD, MPH; e-mail, john.[email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “Leave My Soul Alone!” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Leave My Soul Alone!” by Jack Coulehan, MD, MPH Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics July 2022Volume 175, Issue 7Page: 1048 ePublished: 19 July 2022 Issue Published: July 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Determinants of Spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2
Authors: Chiara Pastorio, Fabian Zech, Sabrina Noettger, Christoph Jung, Timo Jacob, Theo Sanderson, Konstantin M.J. Sparrer, Frank Kirchhoff
Journal: Cell Host & Microbe (2022)

SARS-CoV-2 Omicron rapidly outcompeted other variants and currently dominates the COVID-19 pandemic. Its enhanced transmission and immune evasion are thought to be driven by numerous mutations in the Omicron Spike protein. Here, we systematically introduced BA.1 and/or BA.2 Omicron Spike mutations into the ancestral Spike protein and examined the impacts on Spike function, processing, and susceptibility to neutralization. Individual mutations of S371F/L, S375F, and T376A in the ACE2-receptor-binding domain as well as Q954H and N969K in the hinge region 1 impaired infectivity, while changes to G339D, D614G, N764K, and L981F moderately enhanced it. Most mutations in the N-terminal region and receptor-binding domain reduced the sensitivity of the Spike protein to neutralization by sera from individuals vaccinated with the BNT162b2 vaccine and by therapeutic antibodies. Our results represent a systematic functional analysis of Omicron Spike adaptations that have allowed this SARS-CoV-2 variant to dominate the current pandemic.
Black, Incarcerated, and Dying: Reflections on Racism and Inequities in Health Care
Authors: Catherine S. Hwang
Journal: Annals of Internal Medicine (2022)

On Being a DoctorJuly 2022Black, Incarcerated, and Dying: Reflections on Racism and Inequities in Health CareCatherine S. Hwang, MD, MSPHCatherine S. Hwang, MD, MSPHVirginia Mason Medical Center, Seattle, WashingtonSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M22-0242 Audio Reading - “Black, Incarcerated, and Dying: Reflections on Racism and Inequities in Health Care” Audio. Virginia L. Hood, MD, a physician from the University of Vermont, reads “Black, Incarcerated, and Dying: Reflections on Racism and Inequities in Health Care” by Catherine S. Hwang, MD, MSPH Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Three days after Christmas, during my first year of internal medicine residency, I received handoff about a patient who I will call John. He was being transferred from the intensive care unit to our hospital medicine service. John was paralyzed in all four extremities and unable to speak after having had a stroke, although he maintained decisional capacity with the limited ability to gently nod and shake his head in response to yes-or-no questions. Our inpatient neurology and palliative care teams had been consulted in the intensive care unit, and I was instructed to transition him to comfort care. All ... Author, Article, and Disclosure InformationAffiliations: Virginia Mason Medical Center, Seattle, WashingtonCorresponding Author: Catherine S. Hwang, MD, MSPH, Virginia Mason Medical Center, 925 Seneca Street, H8-GME, Seattle, WA 98101; e-mail, Catherine.[email protected]org. PreviousarticleNextarticle Advertisement Audio Reading - “Black, Incarcerated, and Dying: Reflections on Racism and Inequities in Health Care” Audio. Virginia L. Hood, MD, a physician from the University of Vermont, reads “Black, Incarcerated, and Dying: Reflections on Racism and Inequities in Health Care” by Catherine S. Hwang, MD, MSPH Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics July 2022Volume 175, Issue 7Page: 1047-1048 ePublished: 19 July 2022 Issue Published: July 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...