tbuckley/cabot-search huggingface dataset:
Celebrating the ACP Centennial: From the <i>Annals</i> Archive
Authors: Deborah Cotton
Journal: Annals of Internal Medicine (2015)

Editorials3 March 2015Celebrating the ACP Centennial: From the Annals ArchiveDeborah Cotton, MD, MPH, Deputy EditorDeborah Cotton, MD, MPH, Deputy EditorSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-0178 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail During the 2015 centennial year of the American College of Physicians, publisher of Annals of Internal Medicine, Annals editors will link an article in each issue with an earlier paper from our archives addressing the same disease or clinical question. We hope our readers find this interesting and we welcome comments, especially from physicians who were practicing at the time of publication of the original paper who might offer insight into the impact of the earlier paper on their knowledge or practice.In this issue, Gilbey and Spivey (1) discuss the extreme ethical and personal challenges of caring for Syrian ...References1. Gilbey P, Spivey S. Healing the enemy: the personal narrative of an Israeli surgeon. Ann Intern Med. 2015;162:389-90. doi:10.7326/M14-1848 LinkGoogle Scholar2. Ofran Y, Giryes SS. To be a doctor in Jerusalem: life under threat of terrorism. Ann Intern Med. 2004;140:307-8. [PMID: 14970156]. doi:0003-4819-140-4-200402170-00015 LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTo Be a Doctor in Jerusalem: Life under Threat of Terrorism Yishai Ofran and Shaden Salameh Giryes Healing the Enemy: The Personal Narrative of an Israeli Surgeon Peter Gilbey and Savannah E. Spivey Healing the Enemy: The Personal Narrative of an Israeli Surgeon Peter Gilbey and Savannah E. Spivey Metrics 3 March 2015Volume 162, Issue 5Page: 384KeywordsArabic peopleArchives ePublished: 3 March 2015 Issue Published: 3 March 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Photodynamic therapy is more effective than imiquimod for actinic keratosis in organ transplant recipients: a randomized intraindividual controlled trial
Authors: K. Togsverd-Bo, C. Halldin, C. Sandberg, H. Gonzalez, A.M. Wennberg, S.S. Sørensen, H.C. Wulf, M. Hædersdal
Journal: British Journal of Dermatology (2018)

Summary Recipients of organ transplants such as a kidney must take strong drugs to prevent organ rejection. These drugs also reduce the body's defences against the development of cancer. This is particularly important in the skin, where damage from ultraviolet light from the sun leads to precancerous changes (solar keratoses) on exposed sites. These changes can be extensive and are more likely to develop into aggressive skin cancers than in normal healthy individuals. This Scandinavian study compares the effectiveness and acceptability of two established treatments for solar keratoses in a group of 35 organ transplant patients. Photodynamic therapy (PDT) is administered at a hospital visit. It involves applying a light-sensitising cream to the skin which is later activated by a red light. This triggers intense inflammation in the skin which destroys abnormal but not normal tissue. Another treatment is imiquimod cream which is applied three times a week for four weeks by the patient at home. It stimulates the body's own defence mechanisms to fight off abnormal tissue changes. Each patient had two similarly affected areas of skin. These were randomly allocated to be treated either with PDT or imiquimod. PDT was repeated after three, and imiquimod after two months if necessary. Response rates were calculated at three and six months. This study showed that photodynamic therapy was more effective than imiquimod at reducing the number of persistent solar keratoses in this group of high-risk patients. Although PDT was more painful than imiquimod, patients did not prefer one treatment over the other for this reason.
Microbubbles Show Promise for Enhancing Ultrasound Signal, Image, Other Applications
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Annales Paediatriae Fenniae, Helsinki
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE STATISTIC EVIDENCES OF THE VALUE OF VACCINATION TO THE HUMAN RACE, PAST, PRESENT AND FUTURE.
Authors: EUGENE FOSTER
Journal: JAMA (1896)

<h3>Proposition 7.</h3> In some communities and even nations a greater number of vaccinated and unvaccinated persons are attacked with smallpox. Anti-vaccinationists parade such instances and use such data to bolster up their ridiculous assertions that such facts show the utter futility of vaccination. Without a single exception every such effort is based upon the most shameful perversion of facts. Let us take Great Britain to illustrate this proposition. It is true that in the epidemic of smallpox, 1871-72, a greater number of vaccinated died than those unvaccinated. But does this fact prove the failure of vaccination! By no means. Why? The vaccinated portion of the population number thirty to forty times that of the unvaccinated. In 1872 there were 300,000 of children under 5 years of age in Great Britain (Sir Lyon Playfair,<i>loc. cit.</i>). These were divisible into two classes, vaccinated and unvaccinated. The vaccinated were thirty to forty
Stridor of recent onset
Authors: J. D. Siegel
Journal: JAMA (1975)

<h3>History</h3> A 56-year-old woman with a heavy smoking history was admitted to the hospital for stridor of three weeks' duration. An anteroposterior chest roentgenogram was obtained (Fig 1) (below), followed by mediastinal tomography (Fig 2) (right). <h3>Diagnosis</h3> Tracheogenic carcinoma. <h3>Comment</h3> The chest roentgenogram (Fig 1) shows severe narrowing of the trachea above the carina with slight widening of the mediastinum. There is loss of lung volume on the right and a right lower infiltrate. The mediastinal tomogram (Fig 2) shows a symmetrical concentric mass that has reduced the trachea lumen to a diameter of 3 mm. At fiberoptic bronchoscopy, a solid fusiform tumor narrowing the tracheal lumen was noted. A biopsy specimen disclosed a well-differentiated squamous cell carcinoma. Because of severe coronary artery disease, the patient was not a surgical candidate, and therefore was treated with radiotherapy and corticosteroids to reduce tracheal edema. The patient noted marked decrease in her
Radiosensitizing Nucleosides
Authors: C. J. McGinn, D. S. Shewach, T. S. Lawrence
Journal: JNCI Journal of the National Cancer Institute (1996)

Chemotherapeutic drugs that perturb nucleotide metabolism have the potential to produce substantial sensitization of tumor cells to radiation treatment. The process is called radiosensitization, and the agents that induce it are called radiosensitizers. The clinical effectiveness of fluoropyrimidines as radiosensitizers has been proven in multiple randomized trials. Thymidine analogues and hydroxyurea also appear to produce clinically relevant increases in radiation sensitivity. Recent laboratory investigations have identified difluorodeoxycytidine (gemcitabine) and fludarabine as promising agents to use in combination with radiation. Until recently, little was known about how the biochemical changes caused by these drugs produced radiosensitization. However, advances in related fields, such as cell cycle checkpoint control, have permitted the development of a hypothesis that may explain the relative tumor selectivity of fluoropyrimidine-mediated radiosensitization. In addition, recent findings suggest that the rational manipulation of drug administration schedules and the use of combinations of radiosensitizers have the potential to improve the efficacy of the currently used agents and to establish the benefit of new ones. [J Natl Cancer Inst 1996;88:1193–1203]
Aneurysmal degeneration of femoropopliteal arterial homografts
Authors: H. B. Barner
Journal: JAMA (1966)

The evanescent era of the arterial homograft began nearly 12 years ago and ended five years later in most centers. It is of interest to obtain a long-term evaluation of this method of arterial reconstruction not only to place it in its proper perspective but also because arterial homografts are once again being used. Organ homotransplantation entails homotransplantation of moderate and smaller-sized arteries which may be vulnerable to the same degenerative changes as the isolated arterial homograft. Thirty-five femoropopliteal arterial homografts have been reviewed, with the observation that all of the patent grafts have become aneurysmal. This finding has led us to believe that all similar-sized homografts that remain patent will eventually become aneurysmal. <h3>Clinical Material</h3> Arterial homografts were obtained from patients under 45 years of age who died following trauma or nonmalignant and noninfectious diseases. The grafts were removed under sterile conditions, placed in physiologic saline containing 500,000 units
Lithium carbonate for recurrent fever and neutropenia
Authors: R. H. Gerner
Journal: JAMA (1981)

THERE are several well-described, although not necessarily distinct, febrile, noninfectious, recurrent illnesses with normal-intervening intervals as follows: intermittent hydrarthrosis, familial Mediterranean fever (FMF), cyclic neutropenia (cyclic hematopoiesis), and periodic hypothalamic discharge. Although many of these disorders have been recognized for years, they are often misdiagnosed and frequently are discovered only after long and difficult diagnostic evaluation.<sup>1</sup>No specific origins characterize these disorders, and effective drug therapy is available for only two of these disorders: colchicine for FMF<sup>2</sup>and prednisone for cyclic neutropenia.<sup>3</sup>We report a case of recurrent fever and neutropenia that responded to therapy with lithium carbonate. The control of human body temperature is complicated and has recently been reviewed.<sup>4</sup>In patients with recurrent fevers, the following causes might be found: abnormal production or release of endogenous pyrogen from host phagocytic cells; abnormalities of the hypothalamic thermoregulatory center's response to endogenous pyrogen; or abnormalities of
Sonographically guided percutaneous renal interventional procedures
Authors: R. Kutcher
Journal: JAMA (1984)

THE INCREASING use of percutaneous aspiration techniques has led to a variety of alternatives to surgical procedures for patients with diagnostic problems relating to the kidney and perirenal areas. The accessibility of the genitourinary tract to ultrasound and the absence of radiation afforded by its use make ultrasound a desirable modality for a number of interventional procedures. Table 1 lists the spectrum of diagnostic and therapeutic interventional procedures performed under sonographic guidance at the Montefiore Medical Center from 1975 to May 1983. <h3>Renal Biopsy</h3> The kidney was one of the first organs to be selected for percutaneous biopsy. In the past 30 years, the superiority of percutaneous biopsy over open biopsy has been well established for its high yield and low morbidity.<sup>1</sup>Both ultrasonic and fluoroscopic localization techniques are considered equal in accuracy. Ultrasound is advantageous because it is a gross anatomic examination and does not depend on renal
High Dose (HD-AraC) Vs Standard Dose Cytosine Arabinoside (SD-AraC) During Induction and IL-2 Vs Observation After Consolidation/Autologous Stem Cell Transplantation in Patients with Acute Myelogenous Leukemia (AML): Final Report of the AML-12 Trial of EORTC and GIMEMA Leukemia Groups on the Value of Low Dose IL-2 Maintenance,
Authors: Roelof Willemze, Stefan Suciu, Franco Mandelli, Stijn J.M. Halkes, Jean-Pierre Marie, Boris Labar, Adriano Venditti, Petra Muus, Martin Mistrik, Andrea Camera, Domenico Magro, Lorella Melillo, Dominique Bron, Silvana Magrin, Dominik Selleslag, Domenico Pastore, Silvia Trisolini, Paola Fazi, Matthias Karrasch, Marco Vignetti, Sergio Amadori, Theo M. de Witte, Giovanna Meloni
Journal: Blood (2011)
Agranulocytosis Due to Oxyphenbutazone
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ascitic fluid adenosine deaminase insensitivity in detecting tuberculous peritonitis in the United States
Authors: D Hillebrand
Journal: Hepatology (1996)

Tuberculous peritonitis, although common in Third World countries, remains an uncommon cause of ascites in the United States. Ascitic fluid adenosine deaminase (ADA) activity has been proposed as a useful diagnostic test. The aim of this retrospective study was to determine the clinical utility of ascitic fluid ADA activity in diagnosing tuberculous peritonitis in a U.S. patient population. A total of 368 ascitic fluid specimens from a well-characterized ascitic fluid bank, including tuberculous peritonitis (n = 7), tuberculous peritonitis in the setting of cirrhosis (n = 10), and consecutive specimens of widely varied etiologies (n = 351) were analyzed for ADA activity by ultraviolet spectrophotometry at 265 nm. The overall sensitivity of the ADA determination in diagnosing tuberculous peritonitis was only 58.8%, and the specificity was 95.4%. The accuracy of ADA determination (93.8%) compared favorably with that of the common ascitic fluid tests of white blood cell (WBC) count (>500/mm3), total protein (>2.5 g/dL), and combined WBC count and total protein (45.8%, 74.4%, and 81.3%, respectively). However, ADA was only 30% sensitive in detecting tuberculous peritonitis in the setting of cirrhosis, and cirrhosis was present in 59% of the tuberculous peritonitis patients in our population. In addition, malignancy-related ascites (13%) and bacterial peritonitis specimens (5.8%) occasionally yielded false-positive results. In conclusion, our results indicate that the ascitic fluid ADA activity has good accuracy but poor sensitivity and imperfect specificity in a U.S. patient population in which the prevalence of tuberculosis is low and underlying cirrhosis is common.
What's new in the other general journals
Authors: Christopher Martyn
Journal: BMJ (2005)

The quality of medical care is best judged by patients' outcomes. But such data are often slow and difficult to collect. It's easier to measure process instead—the proportion of eligible patients who received a recommended treatment, for example. Where the recommended treatment is established as effective, this is fair enough. In many settings, however, particularly in the community, the relation between improved performance on measures of process of care and better health outcomes is little more than an assumption. The findings of a study of elderly people, in which this assumption was put to the test, are reassuring. Using medical records of almost 400 elderly people living in the community, researchers assessed the quality of medical care received by using a broad set of process indicators. On average, these people had received about half the recommended care, but there was a large variation between individuals. These people were followed up for three years. After adjustment for sex, illnesses at baseline, and frequency of use of health services, no relation between quality and mortality was evident in the first 18 months of observation. After this, people with higher quality scores had lower mortality, and the difference increased as time went on. Annals of Internal Medicine2005;143:274–81 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Before varicella vaccine was invented, almost everyone experienced chickenpox, usually in childhood. Routine vaccination started in the United States in 1995 and, by 2002, coverage in children aged 19 to 35 months was more than 80%. Not surprisingly, the incidence of chickenpox has declined considerably. Rather more importantly, medical complications related to varicella have also fallen substantially. Using data from a national database of health insurance plans, investigators tracked trends in varicella related hospitalisations, visits to doctors, and medical costs between 1994 and 2002. Compared with the prevaccination period, hospitalisations fell by 88% and visits to doctors by 59%. The … [1]: {openurl}?query=rft.jtitle%253DAnnals%2Bof%2BInternal%2BMedicine%26rft.stitle%253DANN%2BINTERN%2BMED%26rft.issn%253D0003-4819%26rft.aulast%253DHigashi%26rft.auinit1%253DT.%26rft.volume%253D143%26rft.issue%253D4%26rft.spage%253D274%26rft.epage%253D281%26rft.atitle%253DQuality%2Bof%2BCare%2BIs%2BAssociated%2Bwith%2BSurvival%2Bin%2BVulnerable%2BOlder%2BPatients%26rft_id%253Dinfo%253Adoi%252F10.7326%252F0003-4819-143-4-200508160-00008%26rft_id%253Dinfo%253Apmid%252F16103471%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.7326/0003-4819-143-4-200508160-00008&link_type=DOI [3]: /lookup/external-ref?access_num=16103471&link_type=MED&atom=%2Fbmj%2F331%2F7516%2F537.atom [4]: /lookup/external-ref?access_num=000231237100004&link_type=ISI
Bizarre Parosteal Osteochondromatous Proliferation Detected by Tl-201 Scintigraphy
Authors: GAVIN CHRISTOPHER MACKIE
Journal: Clinical Nuclear Medicine (2003)

Bizarre parosteal osteochondromatous proliferation (BPOP) is a rare condition that most commonly affects the tubular bones of the hands and feet. Although benign, it is locally recurrent in 50% of cases after conservative excision. The lesion must be distinguished from benign causes such as osteochondroma and malignant causes such as parosteal osteosarcoma and chondrosarcoma. A case of BPOP detected by TI-201 and Tc-99m MDP scintigraphy is presented, demonstrating early uptake and delayed retention of TI-201 and increased osteoblastic activity. The scintigraphic findings might be confused with a malignant cause, but combined imaging features can suggest the diagnosis before operation.
Marathon running after myocardial infarction
Authors: T. Kavanagh
Journal: JAMA (1974)

Eight patients, who had an aerobic power (maximum oxygen consumption) initially predicted as 72% of normal, were trained to the point of participation in the Boston Marathon one to four years after a demonstrated myocardial infarction. Seven of the eight completed the race at an average speed of 5.4 mph, corresponding to 81% of their maximum oxygen consumption. Symptoms and signs, both immediately after the race and later, were remarkably few. However, a substantial (4 kg) weight loss was incurred, with attendant dangers of heat stress. There was evidence of increased membrane permeability and protein catabolism (elevated levels of blood urea, creatinine, and creatinine phosphokinase) to a total of some 50 gm. Resting serum uric acid levels were normal. Marathon running should not be undertaken as a routine endeavor in post-myocardial infarction rehabilitation. (<i>JAMA</i>229:1602-1605, 1974)
Muscular Activity.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal