tbuckley/cabot-search huggingface dataset:
Experiences with Autotransfusions
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eosinophilic Granuloma of the Gastrointestinal Tract
Authors: C. S. Pitchumoni
Journal: JAMA (1970)

Eosinophilic granuloma of the gastrointestinal tract is a rare disease which may involve the gastrointestinal tract diffusely or as localized polyps. The diffuse form of the disease may be diagnosed by peroral small-bowel biospy. The clinical features mimic many conditions which require surgery, and the diagnosis can only be made histologically. When laparotomy is not urgently required, surgical exploration may be avoided by the use of peroral biopsy to make the diagnosis.
National Tuberculosis Association
Journal: New England Journal of Medicine (1952)

Reviewslogue, the work is one which should be possessed by all those interested in the great Belgian anatomist.It contains far more fact than fancy, and the list of Vesaliana is an important one.Perhaps in I964, which will mark the four hundredth anniversary of the death of Vesalius, a more extended and carefully prepared version of the present catalogue could be issued.It may be recalled that plans for a great celebration in 1914 were never realized due
Multiplication of Avian Leukosis Virus in the Reproductive System of the Rooster&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Henry S. Di Stefano, Robert M. Dougherty
Journal: JNCI Journal of the National Cancer Institute (1968)

Electron microscopic examination of reproductive organs from male chick embryos and roosters, congenially infected with avian leukosis virus, revealed viral multiplication in all connective tissue elements, in smooth muscle within walls of tubular structures, and in nongerminal epithelial cells. There was no evidence of viral budding from germinal cells in either embryos or adult roosters. Many free viral particles were found among connective tissue and smooth muscle cells, and some free particles were seen in lumina of tubular structures.
An Outbreak of Multiple-Drug-Resistant Salmonella Enteritis From Raw Milk
Authors: Carol O. Tacket
Journal: JAMA (1985)

In early 1983, an outbreak of illness caused by raw milk contaminated with multiple-antimicrobial-resistant<i>Salmonella typhimurium</i>occurred in Arizona. One of the cases involved a 72-year-old woman who died with<i>Salmonella</i>enteritis and sepsis that had not responded to treatment with chloramphenicol. The<i>S typhimurium</i>isolates from this patient, from other ill persons, and from raw milk were resistant to ampicillin, chloramphenicol, kanamycin sulfate, streptomycin, sulfonamide, and tetracycline. These resistances were mediated by a 105-megadalton R plasmid. During the epidemic period, 43% of the<i>S typhimurium</i>isolates submitted to the Arizona Department of Health Services were resistant to chloramphenicol, and 80% of these possessed the same plasmid resistance. Although there was evidence of spread of the<i>S typhimurium</i>in the community, there was no evidence of spread of this<i>Salmonella</i>R plasmid to the normal flora of patients or their family members a median of 14 weeks after the infection. This outbreak demonstrates the ability of drug-resistant<i>Salmonella</i>to spread from the animal to the human reservoir and, in a suitable host, produce a fatal infection. (<i>JAMA</i>1985;253:2058-2060)
Inhibition of the Immune Response by Phenylalanine
Authors: Wayne L. Ryan
Journal: JAMA (1965)

In a previous study,<sup>1</sup>phenylalanine (L-phenylalanine) was found to cause an inhibition of the immune response to diphtheria toxoid in rabbits and rats. Because phenylalanine interferes with the in vitro uptake of histidine, ornithine and tyrosine by the brain,<sup>2</sup>it appeared that phenylalanine may inhibit antibody synthesis by limiting the uptake and intracellular availability of essential amino acids. A reduction in availability of amino acids may be the ultimate cause of the decrease of antibody synthesis. The purpose of the present study was to analyze possible mechanisms of phenylalanine inhibition of the immune response and to determine if phenylalanine will inhibit the homograft reaction. Materials and Methods <h3>Amino Acid Analyses.—</h3> Twenty C57/HeJ mice were injected intraperitoneally with phenylalanine, 100 mg/day, for four days. The mice were killed by decapitation three hours after the last injection. The spleens were removed immediately, weighed, and frozen on solid carbon dioxide. The
Childhood Brain Tumors and Paternal Occupation in the Aerospace Industry&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Andrew F. Olshan, M.S.
 5, Norman E. Breslow, Ph.D., Janet R. Daling, Ph.D., Noel S. Weiss, M.D., Dr. P.H., Alan Leviton, M.D.
Journal: JNCI Journal of the National Cancer Institute (1986)

Data from a case-control study of childhood brain tumors were analyzed to examine the possibility that paternal occupation in the aerospace industry is related to the development of a brain tumor in offspring. Parents of 51 children with brain tumors diagnosed in western Washington State during 1978–81 were interviewed, and their responses were compared to those of parents of 142 children selected at random from this population. Among all children, proportions of case and control fathers who had ever been employed in the aerospace industry were nearly identical [relative risk (RR) = 0.94; 95% confidence interval (CI) = 0.40–2.19]. Employment in the aerospace industry during the period from 1 year prior to birth to the time of diagnosis and any employment in the manufacturing part of the industry were not associated with increased risk. However, stratification by age at diagnosis revealed an increased risk associated with father's everemployment in the industry (RR = 2.10; 95% CI = 0.79–5.60) for children under 10 years old. A corresponding decreased risk (RR = 0.12; 95% CI = 0.01–1.08) was found for children over 10 years old. Because of the relatively small number of cases with a positive paternal occupational history, interpretations of the difference in the direction of the association according to age at diagnosis must remain tentative ones.
Squamous Cell Carcinoma of the Epiglottis in a Homosexual Man at Risk for AIDS
Authors: May M. Alhashimi
Journal: JAMA (1985)

<h3>To the Editor.—</h3> Lymphoid malignancies, Kaposi's sarcoma, and squamous cell carcinoma of the buccal mucosa have been described in patients with acquired immunodeficiency syndrome (AIDS).<sup>1-4</sup>We have recently seen a patient with this syndrome who developed squamous cell carcinoma of the epiglottis. <h3>Report of a Case.—</h3> In April 1983, a 44-year-old man, who denied alcohol and cigarette use, developed recurrent sore throat and progressive lymphadenopathy. The patient admitted to one prior homosexual contact, but his family suggested that he was a homosexual. In June 1984 he was noted to have oropharyngeal candidiasis and two hard, fixed masses in both submandibular areas, 4X6 cm on the right and 6X8 cm on the left side. His absolute lymphocyte count was 2,160/cu mm; lymphocyte phenotyping tests showed an OKT4/OKT8 (helper/ suppressor) ratio of 432:1,123 (0.38). The patient was anergic to a battery of skin tests. His serum was positive for human T-cell
Chronic intestinal ischaemia.
Authors: J. K. Watt, W. C. Watson, S. Haase
Journal: BMJ (1967)

marked nitrogen retention after the administration of H.G.H. to a patient with Cushing's syndrome.There are conflicting reports on the usefulness of measuring the metabolic response to H.G.H. in predicting the growth response to long-term H.G.H. therapy.Prader et al. (1964), using a dose of 2 mg./sq.m. body surface area daily (Raben preparation), found that four primordial dwarfs sustained only slight nitrogen retention with H.G.H. and failed to respond to long-term therapy, while six out of nine hypopituitary dwarfs who all sustained marked nitrogen retention showed a satisfactory acceleration of growth with long-term H.G.H. therapy.The three exceptions were patients who developed high titres of antibody to H.G.H. in the course of treatment.We have followed the growth response of only four patients, but it did appear that, in them, the degree of nitrogen retention was related to their subsequent course.Wright et al. (1965), using a Wilhelmi preparation 5 mg.daily, however, were unable to find any parameter in the metabolic response which was of use in predicting subsequent growth response, with the possible exception of minimal nitrogen retention, which was associated with failure of acceleration of growth with chronic H.G.H. therapy. SoumaryThe acute metabolic response to injected human growth hormone (H.G.H.) has been compared in seven patients with panhypopituitarism, six cases of idiopathic dwarfism, three cases of gonadal dysgenesis, three patients dwarfed as a result of chronic corticosteroid treatment, one case of Cushing's syn- drome, and three adults without pituitary disease.Change in blood urea appeared to be the most sensitive factor.The acute metabolic response was greater in patients with hypopituitarism than in those without primary pituitary disease.Measurements of endogenous H.G.H. in response to insulin hypoglycaemia were made in 15 subjects.The acute metabolic response to injected H.G.H. was greatest in those with no measurable serum H.G.H. in response to insulin.The relevance of the acute metabolic response to the linear growth response was examined in four patients who received long-term treatment with H.G.H.Growth was accelerated only in the three patients showing marked nitrogen retention during the acute metabolic test.
Antibiotic Overprescribing-- Quantity or Quality?
Authors: T. J. Mrazik, E. T. Cookson, L. Hopkins
Journal: JAMA (1989)

<h3>To the Editor.—</h3> A letter in the December 23/30, 1988, issue of<i>JAMA</i>entitled "Imipenem Overprescribing" invited clinicians to contribute additional information regarding antibiotic use. The<i>term overprescribing</i>attracted our attention, since it is frequently bandied about in discussion of recently marketed antibiotics. We felt that it would be of interest to physicians and pharmacists to look at prescribing patterns of antibiotics, marketed within the last 7 years, from a national sample of hospitalized patients. <h3>Study. —</h3> We retrospectively reviewed data on parenteral antibiotic use from Pharmaceutical Data Services, Inc, of Scottsdale, Ariz. This computerized database compiles all patient discharge data (disease, procedures, and drug use) contributed from 50 geographically stratified hospitals in the United States. Presently, the database captures a 2% sample of national discharges. The hospitals' characteristics are as follows: teaching, 54%; nonteaching, 46%; nonprofit, 62%; church operated, 22%; for profit, 8%; government, 8%; 400 or more
Marathon Running After Myocardial Infarction
Authors: Robert A. Bruce
Journal: JAMA (1974)

The article of Kavanagh et al of the same title that appears elsewhere in this issue (page 1602) presents extraordinary documentation of the beneficial effects of "competitive" endurance running in eight men between 32 and 49 years of age who survived one or more myocardial infarctions. Although not the first report of successful participation in competitive sports, it exceeds in enthusiasm the report of Gottheiner<sup>1</sup>from Israel. What can we learn from this unusual experience? The men differed in at least two respects from the usual spectrum of survivors of one or more infarctions. They displayed no evidence of any functional aerobic impairment after several months of running 10 to 45 miles per week, and they were unusually well motivated. Averaging reported values of maximal oxygen uptake by "oxygen scale" and by "work scale" coincided with the value predicted by regression on age for active normal men.<sup>2</sup>The
Highlights from Recent Cancer Literature
Journal: Cancer Research (2012)

Friedmann-Morvonski and colleagues report on a study in which they transduced lentiviral vectors to target short hairpin RNAs against Nf1 and p53 (Trp53) into mice carrying a neuron-specific (Synapsin-Cre) transgene in which Cre expression should delete an RFP marker and enable expression of GFP.Viral injection into the hippocampus or ex vivo introduction into the primary cortical neurons led to formation of high-grade glioma.
High-Altitude Retinopathy
Authors: D. Murray McFadden
Journal: JAMA (1981)

Thirty-nine healthy subjects were examined before and after a stay at 5,360 m by ophthalmoscopy and by retinal photography. Twenty of them were also tested for visual acuity, scotomata, and capillary leakage. Vascular engorgement and tortuosity and disc hyperemia were seen in all subjects at altitude and are a "normal" response to hypoxia. Twenty-two (56%) of the subjects had retinal hemorrhages and one showed "cotton-wool spots." These changes are abnormal reactions and are considered high-altitude retinopathy. After maximal exertion on a cycle ergometer, fresh hemorrhages were observed in seven of 34 subjects. The incidence of hemorrhage associated with exercise was significantly greater than predicted. Fluorescein leakage was noted after exercise in eight of 20 persons tested and was associated with exercise-induced hemorrhages. Two persons developed premacular hemorrhages. (<i>JAMA</i>1981;245:581-586)
Syndromes of Q Fever
Authors: Jerachmiel Eshchar
Journal: JAMA (1966)

SINCE THE original description of Q fever, it has been established that<i>Coxiella burnetii</i>has a worldwide distribution. The abundance of reports on epidemic and sporadic cases of Q fever, displaying a protean and often uncharacteristic symptomatology, encouraged us to undertake a systematic study of this disease entity and its part in the causation of various clinical syndromes, such as infectious hepatitis,<sup>1</sup>fever of uncertain origin, and infectious mononucleosis. It is the purpose of this communication to present seven cases of Q fever, five of which were originally labelled "fever of uncertain origin," and two of which displayed a clinical picture suggesting infectious mononucleosis. <h3>Materials and Methods</h3> A group of 119 patients classified as having "fever of uncertain origin" and a group of 13 with the clinical diagnosis of infectious mononucleosis were studied for Q fever. The microscopic-slide agglutination test, introduced by Babudieri<sup>2</sup>was employed in all cases
Advancing America's Health
Authors: Philip R. Lee
Journal: JAMA (1995)

In 1787, Thomas Jefferson wrote, "without health there is no happiness. An attention to health, then, should take the place of every other object." As the process of health system reform moves forward, attention and resources must be directed toward advancing America's health. To direct attention toward health, the US Public Health Service is developing strategies that: Restructure the health care system to focus on the health of populations. Define and strengthen the public health system. Ensure public health agencies and health care plans collaborate to respond to local community needs. Build infrastructure—information systems, research, workforce—to advance health. Realize responsible social policies. I call this fivefold strategy "reinventing public health." Although Congress did not enact comprehensive health system reform this year, the American health care system is experiencing profound change, particularly in the private sector. A major part of the health care system is moving away from
Where Did Good Old Clinical Diagnosis Go?
Authors: Yoseph Rozenman, Dan Gilon, Shmuel Fuchs
Journal: New England Journal of Medicine (1997)

A 65-year-old man had persistent weakness and limitation of activity three months after coronary-artery bypass surgery. He had been well until two weeks before surgery, when he was admitted to the hospital with generalized weakness and diaphoresis but without chest pain. A diagnosis of acute inferior-wall myocardial infarction was based on electrocardiographic changes and an elevated creatine kinase concentration. A transthoracic echocardiogram at that time showed severe inferior and lateral hypokinesia with mild-to-moderate mitral regurgitation. Cardiac catheterization revealed three-vessel coronary artery disease, a left ventricular ejection fraction of 47 percent, and mild-to-moderate mitral regurgitation. He underwent double bypass surgery . . .
Swine Flu Vaccine and Multiple Sclerosis
Authors: Leonard T. Kurland
Journal: JAMA (1984)

Using age-specific rates for multiple sclerosis (MS) based on a national survey, the number of "naturally occurring" new cases of MS among the 45 million swine flu vaccine recipients in the United States is estimated as 1,624 during the year after vaccination, or 31 cases per week. Information from available reports and publications indicates no excess over the expected frequencies. Analyses of admissions for MS before, during, and after the immunization program showed no increase to the US Army hospitals or to the Mayo Clinic. Three independent controlled clinical investigations performed on patients with MS showed no increase in the frequency of exacerbations among those receiving swine flu vaccine as compared with those receiving placebo. Epidemiologic features of MS do not implicate killed virus vaccine as an etiologic factor in onset or exacerbations of the disease. There is no indication from these analyses of any association or cause-and-effect relationship between swine flu vaccine and MS. (<i>JAMA</i>1984;251:2672-2675)
Text-Book of Ophthalmic Operations.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Informed Consent: An Evaluation of Patients' Understanding and Opinion (with Respect to the Operation of Transurethral Resection of Prostate)
Authors: K Chee Saw, Alison M Wood, Karen Murphy, John R W Parry, W Guy Hartfall
Journal: Journal of the Royal Society of Medicine (1994)

The ability of patients to understand and recall information given prior to obtaining written consent was assessed in 55 patients who were due to undergo the operation of transurethral resection of prostate. The patients were also asked their opinion on informed consent. Most patients knew the position of the prostate and the purpose of the operation. Some aspects of the postoperative management and complications were less well remembered. In particular, 18% of the patients could not remember the possibility of retrograde ejaculation despite efforts to emphasize this. Of the patients who returned their questionnaires, 41% did not mind what happened to them provided they were made better; 54% trusted their doctor to do the right thing and did not think detailed explanation was important; 62% felt that consent forms are to protect the doctors' right; still most patients felt that consent forms were necessary. Sub-groups comparison showed no relationship between patients' attitude and their ability to recall information.
Modern Urology in Original Contributions by American Authors.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endoscopy International Open – recently published
Journal: Endoscopy (2017)

Comment on: Evaluation of microvascular findings of deeply invasive colorectal cancer by endocytoscopy with narrow-band imagingEndosc Int Open eFirstDOI: 10.1055/s-0042-117629 Comment on: Chromoendoscopy in combination with random biopsies does not improve detection of gastric cancer foci in CDH1 mutation positive patientsEndosc Int Open 2016; 04(12): E1305-E1310DOI: 10.1055/s-0042-112582
XIV. Medical Journalism, 1847-1883
Authors: Lester S. King
Journal: JAMA (1983)

In 1883, when<i>JAMA</i>was founded, the United States already had a long tradition of medical journalism, amply covered in recent literature.<sup>1</sup>The first medical journal,<i>The New York Repository</i>, had appeared in 1797 as a quarterly. It survived until 1824, and in its modest life it issued a total of 23 volumes. While several other short-lived journals were published in the early years of the 19th century, two especially important periodicals still continue—the<i>New England Journal of Medicine and Surgery</i>and the<i>American Journal of the Medical Sciences</i>. The former started in 1812 as a quarterly. In 1828 it was consolidated with another journal, the<i>Boston Medical Intelligencer</i>, to become a weekly, the<i>Boston Medical and Surgical Journal</i>. Only in 1928 did the journal, without loss of continuity, assume its present title, the<i>New England Journal of Medicine</i>. What is now the<i>American Journal of the Medical Sciences</i>