tbuckley/cabot-search huggingface dataset:
A NOVEL THEORY OF CANCER.
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetics
Authors: Virginia Apgar
Journal: JAMA (1962)

This new text is designed for a beginning course in genetics, probably for college students. Although much of the discussion is based on the time-honored<i>drosophila melanogaster</i>, the busy physician will find certain parts of the book valuable to him in his dealing with patients, especially in view of the recent, rapid advances in human genetics. Chapter 14, on genes and the biochemistry of the organism, is especially pertinent. The discussion of cell structure, desoxyribose nucleic acid (DNA), and ribonucleic acid (RNA) in chapter 2 is commendable, for many geneticists still hold the relation of nucleic acids to genes and chromosomes in high suspicion. Almost too briefly, chapter 1 describes modern techniques in the study of cells. Appendix C, which lists 32 laboratories in North America where human genetic studies are being conducted, is especially useful. The less busy physician, or the physician with a special interest in genetics, would
Using a Self-Report Depression Scale to Identify Remission in Depressed Outpatients
Authors: M. Zimmerman
Journal: American Journal of Psychiatry (2004)

OBJECTIVE: Some have suggested that standardized rating scales be used in clinical practice to monitor the course of treatment; however, the time demands of clinical practice make it difficult to use such measures. This study derived a cutoff on a self-report depression questionnaire corresponding to the most widely used definition of remission (a score ≤7 on the 17-item Hamilton Depression Rating Scale). METHOD: Two hundred sixty-seven depressed outpatients were rated on the Hamilton depression scale and completed the Clinically Useful Depression Outcome Scale (CUDOS). The authors used receiver operating curve analysis to examine the ability of the CUDOS to identify remission on the Hamilton depression scale. RESULTS: A high level of agreement was found between the self-report and Hamilton depression scale assessments of remission. CONCLUSIONS: Self-report questionnaires represent a practical option for thoroughly and objectively evaluating the course of treatment and determining remission in depressed patients.
Excitability
Authors: W. Burridge
Journal: BMJ (1937)

<h3>Abstract</h3> Animals rely on chemosensory cues to survive in pathogen-rich environments. In <i>C. elegans</i>, pathogenic bacteria are known to trigger aversive behaviors through neuronal perception, and to activate molecular defenses throughout the animal. This suggests that neurons may be able to coordinate the activation of organism-wide defensive responses upon pathogen perception. We find that exposure to volatile pathogen-associated compounds induces cell non-autonomous activation of the endoplasmic reticulum unfolded protein response (UPR<sup>ER</sup>) in peripheral tissues following <i>xbp-1</i> splicing in neurons. This odorant-induced UPR<sup>ER</sup> activation is dependent upon transforming growth factor beta (TGF-β) signaling and leads to extended lifespan and enhanced clearance of toxic proteins. Our data suggest that the cell non-autonomous UPR<sup>ER</sup> rewires organismal proteostasis in response to pathogen detection, pre-empting the arrival of proteotoxic stress. Thus, chemosensation of particular odors may be a novel way to manipulate stress responses and longevity.
Safety, tolerability, pharmacokinetics and pharmacodynamics of a novel farnesoid x receptor (FXR)-TQA3526 in healthy Chinese volunteers: a double-blind, randomized, placebo-controlled, dose-escalation, food effect phase? study
Authors: Jia Xu, Hong Zhang, Hong Chen, Xiaoxue Zhu, Zhong-Nan Xu, Dandan Huo, Haiyan Jia, Yanhua Ding, Junqi Niu
Journal: Journal of Hepatology (2020)
Introduction: No Representation without Circulation
Journal: Circulation (2017)

Introduction: No Representation without CirculationFrançois BrunetCirculationArt history finds one origin in the conservation and transmission of precious objects worth guarding against loss or theft, worth displaying, moving and removing, selling or ceding sometimes ...AuthorFrançois BrunetPublisherTerra Foundation for American ArtCopyright© 2017, Terra Foundation for American ArtRelated print edition pages: pp.10-39 https://doi.org/10.37862/aaeportal.00191.001 Stable URL: https://aaeportal.com/?id=-19911Copy Chapter subject tags:Art and historyMethodologyModernism (Art)--United StatesHistoriographyPhotography--United States--History
Human Rights
Authors: Trude Bennett
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The role of plasma in the disturbance of basal cytosolic calcium in platelets from patients with cirrhosis . Liver Research Laboratories, Department of Medicine, Royal Infirmary, Lauriston Place, Edinburgh. Scotland
Journal: Hepatology (1995)

The Na+/Ca2+exchanger (NCX) principal function is taking 1 Ca2+ out of the cytoplasm and introducing 3 Na+. The increase of cytoplasmic Na+ concentration induces the NCX reverse mode (NCXREV), favoring Ca2+ influx. NCXREV can be inhibited by: KB-R7943 a non-specific compound that blocks voltage-dependent and store-operated Ca2+ channels; SEA0400 that appears to be selective for NCXREV, but difficult to obtain and SN-6, which efficacy has been shown only in cardiomyocytes. We found that PPADS, a P2X receptor antagonist, acts as a NCXREV inhibitor in guinea pig tracheal myocytes. In these cells, we characterized the NCXREV by substituting NaCl and NaHCO3 with LiCl, resulting in the increase of the intracellular Ca2+ concentration ([Ca2+]i) using fura 2-AM. We analyzed 5 consecutive responses of the NCXREV every 10 min, finding no differences among them. To evaluate the effect of different NCXREV blockers, concentration response curves to KB-R7943 (1, 3.2 and 10 μM), and SN-6 (3.2, 10 and 30 μM) were constructed, whereas PPADS effect was characterized as time- and concentration-dependent (1, 3.2, 10 and 30 μM). PPADS had similar potency and efficacy as KB-R7943, whereas SN-6 was the least effective. Furthermore, KCl-induced contraction, sensitive to D600 and nifedipine, was blocked by KB-R7943, but not by PPADS. KCl-induced [Ca2+]i increment in myocytes was also significantly decreased by KBR-7943 (10 μM). Our results demonstrate that PPADS can be used as a reliable pharmacological tool to inhibit NCXREV, with the advantage that it is more specific than KB-R7943 because it does not affect L-type Ca2+ channels.
La Roentgenthérapie des Tumeurs Malignes en Oto-Rhino-Laryngologie.
Journal: JAMA (1922)

In a small, compact volume, the authors give a comprehensive account of the subject of roentgenotherapy of malignant tumors of the ear, nose and throat. An excellent historical review is first presented, from the discovery of the roentgen rays by Roentgen in 1896, to the report of Moore and Hautant at the French Congress of Otolaryngology in 1921. The principal authors and a number of abstracts of the work which appeared during this period are given, so that the reader gets a fairly complete idea of the whole subject in the space of fifteen or sixteen pages. The technic of irradiation and of the methods of obtaining the sections for diagnosis is described, and accurate instructions are given to avoid injury to the part which might favor the extension of the malignant growth. The next chapter deals with the clinical facts, and shows the results in the treatment by means
Osler, "E. Y. D.," and hysteria
Authors: R. L. Golden
Journal: JAMA (1982)

IN ADDITION to his many other attributes, Sir William Osler (1849-1919) was highly regarded as a neurologist. His books,<i>The Cerebral Palsies of Children</i><sup>1</sup>and<i>On Chorea and Choreiform Affections</i>,<sup>2</sup>elegantly attest to this. He was the author of occasional pseudonymous papers and letters under the nom de plume of Egerton Yorrick Davis, "late US Army Surgeon."<sup>3</sup>E. Y. Davis, often abbreviated as "E. Y. D.," was Osler's alter ego, his fanciful half that expressed the humorous, jesting side of his nature—a quirk that often got him into trouble.<sup>4(pp239-242),5,6</sup>No doubt "Yorrick" was borrowed from Shakespeare's<i>Hamlet</i>—"Alas, poor Yorick! I knew him, Horatio: a fellow of infinite jest, of most excellent fancy." Reproduced in the Figure is a mock consultation note written by Osler while professor of medicine at Johns Hopkins University and signed "E. Y. D." Although undated, the address allows us to place
The position of health in sustainable development negotiations: a survey of negotiators and review of post-Rio+20 processes
Authors: Michael W Kalmus Eliasz, Neil De Laplante, Anneleen Boel, Gerald J Makuka, Kimberly G Williams, Rispah J Walumbe, Laura Bertani, Claudel Petrin-Desrosiers, Aliye Runyan, Elizabeth Wiley, Usman Mushtaq, Arthur Mello, Sudvhir Singh, Jonathan Meldrum, Roopa Dhatt
Journal: The Lancet Global Health (2013)
Error in Figure.
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Notice
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase III randomized trial comparing intermittent versus continuous androgen suppression for patients with PSA progression after radical therapy: NCIC CTG PR.7/SWOG JPR.7/CTSU JPR.7/UK Intercontinental Trial CRUKE/01/013.
Authors: L. Klotz, C. J. O'Callaghan, K. Ding, D. P. Dearnaley, C. S. Higano, E. M. Horwitz, S. Malone, S. L. Goldenberg, M. K. Gospodarowicz, J. M. Crook
Journal: Journal of Clinical Oncology (2011)

3 Background: In men with PSA recurrence after radical radiotherapy (RRT), intermittent androgen suppression (IAS) has been suggested by phase II trials to improve quality of life (QoL) but effects on survival are unknown. In this Intergroup randomized phase III trial, we compared IAS vs continuous androgen deprivation (CAD) to test for non-inferiority of IAS with respect to overall survival (OS). Methods: Eligible men had rising PSA &gt; 3.0 ng/ml &gt;1 year post RRT, either initial or salvage, for localized prostate cancer. Patients could receive up to 1 year of neo/adjuvant androgen deprivation therapy (ADT) completed &gt;1 year prior. Stratification factors were time since RRT (&gt;1-3 vs &gt;3 years), initial PSA (&lt;15 vs &gt;15), prior radical prostatectomy and prior ADT. IAS was delivered for 8 months in each cycle with restart when PSA reached &gt;10 ng/ml off treatment. Primary endpoint was OS; secondary endpoints included time to hormone refractory state (HR), QoL, cholesterol/HDL/LDL, duration of treatment/non-treatment intervals, time to testosterone and potency recovery. The independent DSMC recommended halting the trial after a planned interim analysis demonstrated that a pre-specified stopping boundary for non-inferiority was crossed. Results: 1,386 patients were randomized to IAS (690) or CAD (696) arms. Arms were balanced for important baseline factors. Median follow up was 6.9 years. IAS patients completed a median of 2 x 8 month cycles (range: 1-9). 524 deaths were observed (268 on IAS vs 256 on CAD). Median OS was 8.8 vs 9.1 years on IAS and CAD arms, respectively (HR 1.02, 95%CI 0.86-1.21; p for non-inferiority [HR IAS vs CAD ≥ 1.25] = 0.009). The IAS arm had more disease related (122 vs 97) and fewer unrelated (134 vs 146) deaths. Time to HR was statistically significantly improved on the IAS arm (HR 0.80, 95%CI 0.67-0.98; p = 0.024). IAS patients had reduced hot flashes, but otherwise there was no evidence of differences in AEs, including myocardial events or osteoporotic fractures. Conclusions: In men with PSA recurrence after RRT IAS, given as described herein, is non-inferior to CAD with respect to OS. No significant financial relationships to disclose.
Isolate Virus-Like Agents That Induce Fatal Leukemoid Disease in Mice
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mendelian Randomization
Authors: Connor A. Emdin, Amit V. Khera, Sekar Kathiresan
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL MEETINGS ON THE PACIFIC COAST.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SP0196 What to Expect from your Mentor and how to Optimize the Mentoring Process
Authors: R.E. Gay
Journal: Annals of the Rheumatic Diseases (2013)

<h3></h3> <b>What to expect from your mentor and how to optimize the mentoring process</b> Mentorship refers to a developmental relationship between a more experienced mentor and a less experienced partner referred to as a protégé or mentee - a person guided and protected by a more prominent person. And no matter if a person is very young in his or her career or has already some experience, there is still the need for a mentor. It is important to have a person who helps to sort out the big stones of challenge from the gravel, as Stephen R. Covey explains in his book "The 7 habits of highly effective people" (1992 Covey Leadership Center, Inc). There are two types of mentoring relationships: formal and informal. In well-designed formal mentoring programs, there are program goals, schedules, training (for mentors and mentees), and evaluation. Mentors inspire their mentee to reach their goal and support them on their way. A study shows that, in institutions that have a formal mentoring program, employees stay in average twice as long as in institutions without mentoring. Mentoring means provision of: resources, opportunities, advice and protection (David L. Sackett, Clin Invest Med 2001, 24:94-100). Ressources: - space to work - productivity enhancing equipment - money to go to courses and participate in meetings Opportunities: - to carry out review of manuscripts and grants - to accompany mentors to meetings of ethics and grant review committees - to accept requests from prominent, reviewed journals to write editorials, comments or essays (together with the mentor) - to become lead author of such papers - to learn how to network properly Advice: - Creativity: a mentor should encourage the mentee to be creative, for example, to use lateral or horizontal thinking, beside vertical thinking (Hauser MJ, Feinberg D. Problem solving revisited. J Psychiatr Nurs Ment Health Serv. 15(10):13-17 Oct 1977) - Fairness: to connect up with other researchers and to be fair! (Aristotle) - Honesty: to be honest about results - Active listening: should focus on the mentee's development as independent thinkers - Learn to prioritize Protection: - rehearse the presentations in front of the mentor and the team - to recognise and respond appropriately to critical letters from editors and reviewers for publications There are important mentoring programs from different institutions: Articulum fellowship; EULAR: Objectives 2012; EMEUNET. Mentoring and networking always start in the team. <h3>Disclosure of Interest</h3> None Declared