tbuckley/cabot-search huggingface dataset:
Myeloproliferative Patients with Calreticulin Gene Mutations: Clinical Manifestations and Outcome, a Single Institution Experience
Authors: Mohammad Abu-Tineh, Awni Alshurafa, Hana Qasim, Soubiya Ansari, Hazem Faraj, Saif Alateeg, Onur Kurt, Susanna Jane Akiki, Mohamed A Yassin
Journal: Blood (2022)
Gradually Increased Gpiib/Iiia Responsiveness from Preterm and Term Neonatal Infants to Adults Reveals a Complex Phenotypic Switch during Platelet Ontogenesis - Data from the <i>Platelets in Neonatal Infants Study</i> (PLINIUS)
Authors: Oliver Andres, Lukas J. Weiß, Maria Drayss, Kristina Mott, Christoph Haertel, Christian P. Speer, Harald Schulze
Journal: Blood (2022)
Features of the histostructure of the gastric mucosa inpatients with atrophic gastritis combined with thyroid pathology
Authors: Yu.M. Stepanov, L.M. Mosiychuk, Yu.A. Gaidar, O.M. Shevtsova, O.P. Petishko, D.F. Mylostiva
Journal: GASTROENTEROLOGY (2022)

Background. The search for factors that influence the progression of structural remodeling of the gastric mucosa and carcinogenesis remains a promising area of gastroenterology. The purpose of the study: to study the microstructure of the gastric mucosa in patients with chronic atrophic gastritis depending on the presence of structural changes in the thyroid gland. Materials and methods. A study of histostructural changes of the gastric mucosa was carried out in 121 patients with atrophic gastritis, taking into account nodular and diffuse changes in the parenchyma of the thyroid gland. The degree and stage of gastritis were assessed according to the OLGA system. We studied the allergic component, the severity of atrophic changes in the gastric mucosa, the presence and severity of sclerotic changes in the stroma, and epithelial hyperplasia. Ultrasound examination of the thyroid gland was performed on an ultrasound scanner Toshiba Xario (Japan). Results. The distribution of patients according to the frequency of detection of atrophy in different loci of the stomach showed that intestinal metaplasia in the body of the stomach was observed 1.9 times more often in patients with nodular changes than in those with diffuse changes (χ2= 5.33; p&lt; 0.05) and 2.8 times— than in people without structural changes of the thyroid gland (χ2= 8.12; p&lt; 0.01). Similarly, atrophy in the angle of the stomach was most often detected in patients with nodular changes in the thyroid gland— in 65.0% of cases, which is 25.7% more often compared to those with diffuse changes (p&gt; 0.05) and 38.3% more often compared to people without structural changes of the thyroid gland (χ2=6.27; p&lt; 0.05). According to the results of the correlation analysis, a connection was found between the presence of nodular changes in the thyroid gland and the degree of atrophy of the mucous membrane of the body of the stomach (r= 0.49; p= 0.011) and the angle of the stomach (r= 0.52; p= 0.037), the presence of intestinal metaplasia in the mucous membrane of the antral part of the stomach (r= 0.54; p=0.013) and the angle of the stomach (r= 0.41; p= 0.028). Conclusions. The progression of structural changes in the gastric mucosa occurs most often in patients with nodular changes in the thyroid gland. For early diagnosis of precancerous conditions and changes in the mucous membrane of the stomach in patients with structural changes of the thyroid gland, it is advisable to conduct a thorough endoscopic examination of the stomach using modern highly informative technologies.
Dementia (Japanese Version)
Authors: Esther S. Oh, Peter V. Rabins
Journal: Annals of Internal Medicine (2019)

In the Clinic3 September 2019Dementia (Japanese Version)Esther S. Oh, MD, PhD and Peter V. Rabins, MD, MPHEsther S. Oh, MD, PhDJohns Hopkins University School of Medicine, Baltimore, Maryland (E.S.O., P.V.R.) and Peter V. Rabins, MD, MPHJohns Hopkins University School of Medicine, Baltimore, Maryland (E.S.O., P.V.R.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/IsTranslatedFrom_AITC201909030_Japanese SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Editors' Note: This article (available in PDF format) is the translated Japanese version of In the Clinic: Dementia (Oh ES, Rabins PV. Dementia. Ann Intern Med. 2019;171:ITC33-ITC48. doi:10.7326/AITC201909030. Author, Article, and Disclosure InformationAffiliations: Johns Hopkins University School of Medicine, Baltimore, Maryland (E.S.O., P.V.R.)CME Objective: To review current evidence for prevention and screening, diagnosis, and treatment of in the clinic: dementia.Acknowledgment: The authors thank David M. Blass, MD, one of the authors of the previous version of this In the Clinic.Funding Source: American College of Physicians.Disclosures: Dr. Oh, ACP Contributing Author, has nothing to disclose. Dr. Rabins, ACP Contributing Author, reports that he has received royalties for books on related topics. Disclosures can also be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-1237.With the assistance of additional physician writers, the editors of Annals of Internal Medicine develop In the Clinic using MKSAP and other resources of the American College of Physicians.In the Clinic does not necessarily represent official ACP clinical policy. For ACP clinical guidelines, please go to https://www.acponline.org/clinical_information/guidelines/. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDementia Esther S. Oh and Peter V. Rabins Metrics 3 September 2019Volume 171, Issue 5Page: JITC33-JITC48 ePublished: 17 January 2023 Issue Published: 3 September 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Comparison of HER2-targeted affibody conjugates loaded with auristatin- and maytansine-derived drugs
Authors: Wen Yin, Tianqi Xu, Haozhong Ding, Jie Zhang, Vitalina Bodenko, Maria S. Tretyakova, Mikhail V. Belousov, Yongsheng Liu, Maryam Oroujeni, Anna Orlova, Vladimir Tolmachev, Torbjörn Gräslund, Anzhelika Vorobyeva
Journal: Journal of Controlled Release (2023)

Treatment with antibody drug conjugates targeting receptors over-expressed on cancer cells is well established for clinical use in several types of cancer, however, resistance often occurs motivating the development of novel drugs. We have recently investigated a drug conjugate consisting of an affibody molecule targeting the human epidermal growth factor receptor 2 (HER2), fused to an albumin-binding domain (ABD) for half-life extension, loaded with the cytotoxic maytansine derivative DM1. In this study, we investigated the impact of the cytotoxic payload on binding properties, cytotoxicity and biodistribution by comparing DM1 with the auristatins MMAE and MMAF, as part of the drug conjugate. All constructs had specific and high affinity binding to HER2, human and mouse albumins with values in the low- to sub-nM range. ZHER2-ABD-mcMMAF demonstrated the most potent cytotoxic effect on several HER2-over-expressing cell lines. In an experimental therapy study, the MMAF-based conjugate provided complete tumor regression in 50% of BALB/c nu/nu mice bearing HER2-over-expressing SKOV3 tumors at a 2.9 mg/kg dose, while the same dose of ZHER2-ABD-mcDM1 provided only a moderate anti-tumor effect. A comparison with the non-targeting ZTaq-ABD-mcMMAF control demonstrated HER2-targeting specificity. In conclusion, a combination of potent cytotoxicity in vitro, with minimal uptake in normal organs in vivo, and efficient delivery to tumors provided a superior anti-tumor effect of ZHER2-ABD-mcMMAF, while maintaining a favorable toxicity profile with no observed adverse effects.
3D bio-printed living nerve-like fibers refine the ecological niche for long-distance spinal cord injury regeneration
Authors: Jia Yang, Kaiyuan Yang, Weitao Man, Jingchuan Zheng, Zheng Cao, Chun-Yi Yang, Kunkoo Kim, Shuhui Yang, Zhaohui Hou, Guihuai Wang, Xiumei Wang
Journal: Bioactive Materials (2023)

3D bioprinting holds great promise toward fabricating biomimetic living constructs in a bottom-up assembly manner. To date, various emergences of living constructs have been bioprinted for
Comparison of outcome of male versus female laparoscopic cholecystectomy: BMI-adjusted prospective observational study
Authors: Brajesh Kumar, S. Anand, Jafar Husain, Rajesh Sahu, Manas Pattnaik, Vipin VenugopalNair, R. Nagamahendran
Journal: GASTROENTEROLOGY (2023)

Background. Laparoscopic cholecystectomy has become the choice of treatment for symptomatic cholelithiasis and has replaced open cholecystectomy. Numerous studies and scoring system have been developed over the past 2–3 decades which predict the rate of conversion of laparoscopic to open cholecystectomy. Recently, few scoring systems have been developed which incorporates various intraoperative findings to predict this conversion. No studies are available in literature to assess gender-specific and body weight complications in laparoscopic cholecystectomy. The purpose of this study was to compare the outcome of laparoscopic cholecystectomy between male and female patients in terms of preoperative factors, intraoperative difficulties and rate of conversion to open cholecystectomy and common postoperative complications. Materials and methods. This non-randomized, prospective, observational study was conducted at a tertiary care hospital in Northern India from June 2019 to May 2021. Various preoperative data was collected from the patients like age, the American Society of Anesthesiologists (ASA) class, comorbidity, indication for surgery, preoperative ultrasonography findings and any previous surgery. Surgeries in all patients were started with laparoscopic cholecystectomy under general anaesthesia. The outcomes were measured in terms of time taken to complete surgery, whether laparoscopic cholecystectomy was converted to open cholecystectomy, common bile duct/cystic duct injury during surgery, common postoperative complications and average length of hospital stay in days. Results. A total of 300 patients were included in the study: 222 females and 78 males. Mean age of presentation in women was (46.45±11.55) years ranging from 21 to 71 years and in men (51.78±11.49) years ranging from 36 years to 76 years. This difference was statistically significant (p=0.001). The other significant preoperative differences between males and females were comorbidity (p=0.001) and previous surgeries (p=0.001). However, the ASA class under which the patients were operated was not significant (p=0.998). The various indications for surgery to include chronic cholecystitis, resolved acute cholecystitis, gallstone-induced pancreatitis and common bile duct stone had no statistical difference between men and women (p=0.072). Conclusions. This study concludes that intraoperative difficulties were more often in male patients as compared to females. The average operating time, conversion of laparoscopic to open cholecystectomy and postoperative hospital stay were significantly higher in men than in women.
Prognostic value of blood saturated fatty acids in inflammatory bowel diseases
Authors: M.V. Stoikevich, V.A. Karachynova, I.A. Klenina, O.P. Petishko
Journal: GASTROENTEROLOGY (2023)

Background. Pathogenetic factors that cause the development of inflammatory bowel diseases (IBD) remain poorly understood, namely, the peculiarities of saturated fatty acids (SFAs) in the blood serum at different degrees of disease severity, which is quite an important task. Objective: to evaluate serum level of SFAs depending on IBD severity. Materials and methods. Thirty-seven patients with IBD were examined, their average age was (38.5±2.1) years. Depending on the severity of the disease, the patients were divided into 2 groups: group I— with IBD of moderate severity (n=24) and group II— with severe IBD (n=13). The control group consisted of 16 healthy people. The quantitative content of SFAs in the blood serum of the examined patients was determined by gas chromatography. Median (Me), lower (25%) and upper (75%) quartiles were used to describe the data. Results. Biochemical analysis revealed a tendency to decrease in the level of short-chain SFA (butyric acid; p&gt;0.05) and a significant increase in the total content of medium- and long-chain SFAs (MCSFAs and LCSFAs; p&lt;0.001) in the serum of group I and II patients compared to the controls. It was found that with increasing severity of IBD, there was a decrease in LCSFAs content in the blood (r=–0.420, p=0.048). The serum spectrum of SFAs was analyzed and a significant increase in all MCSFAs fractions was detected in both groups of patients: caproic acid (p&lt;0.001), caprylic acid (p&lt;0.001), capric acid (p≤0.002), undecylic acid (p≤0.006) and lauric acid (p≤0.001). Characteristically, the content of the most MCSFAs fractions had a tendency to decrease (p&gt;0.05) in group I against group II of patients. The content of LCSFAs, namely: tridecylic acid (p≤0.012), myristic acid (p&lt;0.001), pentadecylic acid (p≤0.012), palmitic acid (p&lt;0.001), stearic acid (p≤0.001) and heneicosylic acid (p&lt;0.001), increased significantly in group I and II of patients, while the content of margaric and eicosanoic acids— only in group I compared to the controls. Almost all LCSFAs (except tridecylic acid) had a tendency to increase in group I against group II. Conclusions. It has been shown that the content of SFAs in the blood depends on the degree of IBD severity. The mechanism of SFAs action with different carbon chain lengths is multidirectional and is associated with the effect on pro-/anti-inflammatory mediators and with the maintenance of the immune and intestinal homeostasis. The necessity of determining serum SFAs in IBD to correct the identified disorders has been confirmed.
The Surface Morphology of Large Nonpedunculated Colonic Polyps Predicts Synchronous Large Lesions
Authors: Timothy O’Sullivan, David Tate, Mayenaaz Sidhu, Sunil Gupta, James Elhindi, Karen Byth, Oliver Cronin, Anthony Whitfield, Ana Craciun, Rajvinder Singh, Gregor Brown, Spiro Raftopoulos, Luke Hourigan, Alan Moss, Amir Klein, Steven Heitman, Stephen Williams, Eric Lee, Nicholas G. Burgess, Michael J. Bourke
Journal: Clinical Gastroenterology and Hepatology (2023)
Trends in gabapentinoid prescribing in UK primary care using the Clinical Practice Research Datalink: an observational study
Authors: Julie Ashworth, Ram Bajpai, Sara Muller, James Bailey, Toby Helliwell, Sarah A. Harrisson, Rebecca Whittle, Christian D. Mallen
Journal: The Lancet Regional Health - Europe (2023)

The UK government reclassified gabapentin and pregabalin as 'controlled drugs' from April 2019. This study aimed to describe the trends in gabapentinoid prescribing before and immediately after reclassification, in the UK Clinical Practice Research Datalink, an electronic primary care health record broadly representative of the UK.Separately for gabapentin and pregabalin, we calculated annual incident and prevalent prescribing rates from year of UK approval (April 1997 and 2004 respectively) to September 2019, and monthly incident and prevalent prescribing rates (October 2017-September 2019). Significant changes in temporal trends were determined using joinpoint regression. We also described potential prescribing indications, prior pain-related prescribing, and co-prescribing with potentially interacting medicines.Incident gabapentin prescribing increased annually, peaking in 2016-17, at 625/100,000 patient years before falling steadily to 2019. Incident pregabalin prescribing peaked at 329/100,000 patient years in 2017-18 and did not fall significantly until 2019. Prevalent gabapentin and pregabalin prescribing increased annually to 2017-18 and 2018-19 respectively, before plateauing. Gabapentinoids were commonly co-prescribed with opioids (60%), antidepressants (52%), benzodiazepines (19%), and Z-drugs (10%).Following a dramatic rise, incident gabapentinoid prescribing has started to fall but the specific impact of reclassification on prescribing rates remains unclear. Limited change in prevalent gabapentinoid prescribing during the 6 months following their reclassification as controlled drugs suggests little immediate impact on continued gabapentinoid prescribing for existing users.National Institute for Health and Care Research (NIHR) Research for Patient Benefit Programme. NIHR Applied Research Collaboration West Midlands. NIHR School for Primary Care Research.
Clinical Outcomes of Intraductal Papillary Mucinous Neoplasms With Dilatation of the Main Pancreatic Duct
Authors: Tsuyoshi Hamada, Hiroki Oyama, Yousuke Nakai, Shuichi Tange, Junichi Arita, Ryunosuke Hakuta, Hideaki Ijichi, Kazunaga Ishigaki, Sachiko Kanai, Yoshikuni Kawaguchi, Hirofumi Kogure, Suguru Mizuno, Kei Saito, Tomotaka Saito, Tatsuya Sato, Tatsunori Suzuki, Naminatsu Takahara, Mariko Tanaka, Keisuke Tateishi, Tetsuo Ushiku, Kiyoshi Hasegawa, Mitsuhiro Fujishiro
Journal: Clinical Gastroenterology and Hepatology (2023)
Intestinal fibrogenesis in inflammatory intestinal disorders
Authors: М.М. Zhaivoronok, V.N. Zalessky
Journal: GASTROENTEROLOGY (2023)

The article deals with chronic inflammatory processes of the intestines and their complications that contribute to the gradual accumulation of deep transmural lesions of the intestinal wall, including narrowings, development of obstruction, abscesses, and fistulas. Both inflammatory bowel diseases and their chronic complications lead to the onset of diarrhea, abdominal pain, anemia caused by intestinal pathology. Detecting the disease activity and complications severity is of crucial importance in the treatment intensity at early and later stages of the illness and when monitoring treatment measures effectiveness. The main molecular mediators of fibrogenesis are studied in the article, the results of development of intestinal fibrosis visualization technologies are summarized, possibilities for expanding the quantitative magnetic resonance imaging, computed tomography, ultrasound and encouraging potential of non-invasive elastography methods are discussed.
May carriers at nanoscale improve the Endodontic’s future?
Authors: Patrícia Diogo, M. Amparo F. Faustino, Paulo J Palma, Akhilesh Rai, Maria Graça P. M. S. Neves, João Miguel Santos
Journal: Advanced Drug Delivery Reviews (2023)

Nanocarriers (NCs) are dynamic nanovehicles used to transport bioactive derivatives like therapeutical formulations, drugs and/or dyes. The current review assists in understanding the mechanism of action of several recent developed NCs with antimicrobial purposes. Here, nine NCs varieties are portrayed with focus on nineteen approaches that are fulfil described based on outcomes obtained from in vitro antimicrobial assays. All approaches have previously been verified and we underline the biochemical challenges of all NCs, expecting that the present data may encourage the application of NCs in endodontic antimicrobial basic research. Methodological limitations and the evident base gaps made not possible to draw a definite conclusion about the best NCs for achieving efficient antimicrobial outcomes in endodontic studies. Due to the lack of pre-clinical trials and the scarce number of clinical trials in this emergent area, there is still much room for improvement on several fronts.
Lifestyle modification in the treatment of refractory gastroesophageal reflux disease and non-alcoholic fatty liver disease. A clinical case
Authors: V.I. Didenko, V.B. Yagmur, S.L. Melanich, L.V. Demeshkina, O.V. Simonova
Journal: GASTROENTEROLOGY (2023)

The article presents a clinical case of refractory gastroesophageal reflux disease (GERD) in a female patient with non-alcoholic fatty liver disease and morbid obesity. A 38-year-old woman came to the clinic with complaints of heartburn up to 5–6 times a day, other manifestations of pain and dyspeptic syndromes. Morbid obesity, refractory GERD with erosive esophagitis, and hepatic steatosis were diagnosed during follow-up examination. A set of treatment measures was developed, which included lifestyle modification, proton pump inhibitors and ursodeoxycholic acid preparations. During the observation period of 16 months, a gradual decrease in body weight was accompanied by a decrease in the frequency of heartburn. As a result, the patient lost 49kg. During the control instrumental examination, a positive trend was observed in terms of sonographic and endoscopic indicators, as well as a decrease in liver stiffness according to elastography data. A review of the literature on the correlation between obesity, steatosis and reflux disease is given. Conclusion. Obesity and related fatty liver disease can be additional factors for the development of refractory GERD, and a significant reduction in body weight leads to both resolution of reflux disease and improvement of parameters characterizing the structural state of the liver.
Limitations and significance of non-invasive test for assessment of chronic liver disease
Authors: V. Siva Kesava Reddy, Shubham Nimkar, Mansi Patel, Sourya Acharya
Journal: GASTROENTEROLOGY (2023)

The gold standard for assessing liver fibrosis is a liver biopsy. However, the procedure is invasive and is associated with pain and sometimes fatal consequences. The accuracy of liver biopsy results is further harmed by intra- and inter-observer variability. Small samples only. This muddles the two types of observer variability discussed above. Due to these limitations, non-invasive approaches for fibrosis testing have been developed. Various biochemical serum indicators or imaging techniques that provide a physical measure of hepatic stiffness are non-invasive approaches for assessing liver fibrosis.
Matvii Shchoholiev: at the origins of the Katerynoslav Medical Institute
Authors: M.P. Chaban, Z.I. Shevtsova, V.V. Gaponov
Journal: GASTROENTEROLOGY (2023)

The article presents the life and professional activity of zemstvo doctor Matvii Oleksandrovych Shchoholiev. An important part of his life was communication with the historian Dmytro Yavornytskyi. Information about the tragic fate of the doctor’s wife, Yevheniia Dubravska, and her family has been provided. Touching memories of niece Kira Haievska give an idea of the doctor and people around him.