tbuckley/cabot-search huggingface dataset:
Posters (Abstracts 289–2348)
Authors: Daria M Kartasheva-Ebertz, Jesintha Gaston, Loriane Lair-Mehiri, Pierre-Philippe Massault, Olivier Scatton, Jean Christophe Vaillant, Vladimir A. Morozov, Stanislas Pol, Sylvie Lagaye
Journal: Hepatology (2019)

AASLD Publications Hepatology Liver Transplantation Clinical Liver Disease Hepatology Communications AASLD Publications Hepatology Liver Transplantation Clinical Liver Disease Hepatology Communications
Risk-stratified Approach for Never- and Ever-Smokers in Lung Cancer Screening: A Prospective Cohort Study in China
Authors: Fei Wang, Fengwei Tan, Sipeng Shen, Zheng Wu, Wei Cao, Yiwen Yu, Xuesi Dong, Changfa Xia, Wei Tang, Yongjie Xu, Chao Qin, Meng Zhu, Jibin Li, Zhuoyu Yang, Yadi Zheng, Zilin Luo, Liang Zhao, Jiang Li, Jiansong Ren, Jufang Shi, Yao Huang, Ning Wu, Hongbing Shen, Wanqing Chen, Ni Li, Jie He
Journal: American Journal of Respiratory and Critical Care Medicine (2022)

Rationale: Over 40% of lung cancer cases occurred in never-smokers in China. However, high-risk never-smokers were precluded from benefiting from lung cancer screening as most screening guidelines did not consider them. Objectives: We sought to develop and validate prediction models for 3-year lung cancer risks for never- and ever-smokers, named the China National Cancer Center Lung Cancer models (China NCC-LCm2021 models). Methods: 425,626 never-smokers and 128,952 ever-smokers from the National Lung Cancer Screening program were used as the training cohort and analyzed using multivariable Cox models. Models were validated in two independent prospective cohorts: one included 369,650 never-smokers and 107,678 ever-smokers (841 and 421 lung cancers), and the other included 286,327 never-smokers and 78,469 ever-smokers (503 and 127 lung cancers). Measurements and Main Results: The areas under the receiver operating characteristic curves in the two validation cohorts were 0.698 and 0.673 for never-smokers and 0.728 and 0.752 for ever-smokers. Our models had higher areas under the receiver operating characteristic curves than other existing models and were well calibrated in the validation cohort. The China NCC-LCm2021 ⩾0.47% threshold was suggested for never-smokers and ⩾0.51% for ever-smokers. Moreover, we provided a range of threshold options with corresponding expected screening outcomes, screening targets, and screening efficiency. Conclusion: The construction of the China NCC-LCm2021 models can accurately reflect individual risk of lung cancer, regardless of smoking status. Our models can significantly increase the feasibility of conducting centralized lung cancer screening programs because we provide justified thresholds to define the high-risk population of lung cancer and threshold options to adapt different configurations of medical resources.
Clinical and immunophenotypic characteristics of familial leukemia predisposition caused by PAX5 germline variants
Authors: Adela Escudero, Masatoshi Takagi, Franziska Auer, Ulrike Anne Friedrich, Satoshi Miyamoto, Atsushi Ogawa, Kohsuke Imai, Barbara Pascual, María Vela, Polina Stepensky, Layal Yasin, Sarah Elitzur, Arndt Borkhardt, Antonio Pérez-Martínez, Julia Hauer
Journal: Leukemia (2022)
Abstract Supplement 2019 ACR/ARP Annual Meeting
Authors: Océane Landon-Cardinal, Perrine Guillaume-Jugnot, Lois Bolko, Ségolène Toquet, Aude Rigolet, Baptiste Hervier, Nicolas Champtiaux, Mathieu Vautier, Olivier Benveniste, Yves Allenbach
Journal: Arthritis & Rheumatology (2019)

For a searchable version of these abstracts, please visit www.acrabstracts.org.
Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke
Authors: Marios K. Georgakis, Rainer Malik, Harry Björkbacka, Tiberiu Alexandru Pana, Serkalem Demissie, Colby Ayers, Mohamed A. Elhadad, Myriam Fornage, Alexa S. Beiser, Emelia J. Benjamin, S. Matthijs Boekholdt, Gunnar Engström, Christian Herder, Ron C. Hoogeveen, Wolfgang Koenig, Olle Melander, Marju Orho-Melander, Alexandru Schiopu, Martin Söderholm, Nick Wareham, Christie M. Ballantyne, Annette Peters, Sudha Seshadri, Phyo K. Myint, Jan Nilsson, James A. de Lemos, Martin Dichgans
Journal: Circulation Research (2019)

Rationale: Proinflammatory cytokines have been identified as potential targets for lowering vascular risk. Experimental evidence and Mendelian randomization suggest a role of MCP-1 (monocyte chemoattractant protein-1) in atherosclerosis and stroke. However, data from large-scale observational studies are lacking. Objective: To determine whether circulating levels of MCP-1 are associated with risk of incident stroke in the general population. Methods and Results: We used previously unpublished data on 17 180 stroke-free individuals (mean age, 56.7±8.1 years; 48.8% men) from 6 population-based prospective cohort studies and explored associations between baseline circulating MCP-1 levels and risk of any stroke, ischemic stroke, and hemorrhagic stroke during a mean follow-up interval of 16.3 years (280 522 person-years at risk; 1435 incident stroke events). We applied Cox proportional-hazards models and pooled hazard ratios (HRs) using random-effects meta-analyses. After adjustments for age, sex, race, and vascular risk factors, higher MCP-1 levels were associated with increased risk of any stroke (HR per 1-SD increment in ln-transformed MCP-1, 1.07; 95% CI, 1.01–1.14). Focusing on stroke subtypes, we found a significant association between baseline MCP-1 levels and higher risk of ischemic stroke (HR, 1.11 [1.02–1.21]) but not hemorrhagic stroke (HR, 1.02 [0.82–1.29]). The results followed a dose-response pattern with a higher risk of ischemic stroke among individuals in the upper quartiles of MCP-1 levels as compared with the first quartile (HRs, second quartile: 1.19 [1.00–1.42]; third quartile: 1.35 [1.14–1.59]; fourth quartile: 1.38 [1.07–1.77]). There was no indication for heterogeneity across studies, and in a subsample of 4 studies (12 516 individuals), the risk estimates were stable after additional adjustments for circulating levels of IL (interleukin)-6 and high-sensitivity CRP (C-reactive protein). Conclusions: Higher circulating levels of MCP-1 are associated with increased long-term risk of stroke. Our findings along with genetic and experimental evidence suggest that MCP-1 signaling might represent a therapeutic target to lower stroke risk.Visual Overview: An online visual overview is available for this article.
GWAS meta-analysis of 16 790 patients with Barrett’s oesophagus and oesophageal adenocarcinoma identifies 16 novel genetic risk loci and provides insights into disease aetiology beyond the single marker level
Authors: Julia Schröder, Laura Chegwidden, Carlo Maj, Jan Gehlen, Jan Speller, Anne C Böhmer, Oleg Borisov, Timo Hess, Nicole Kreuser, Marino Venerito, Hakan Alakus, Andrea May, Christian Gerges, Thomas Schmidt, Rene Thieme, Dominik Heider, Axel M Hillmer, Julian Reingruber, Orestis Lyros, Arne Dietrich, Albrecht Hoffmeister, Matthias Mehdorn, Florian Lordick, Gertraud Stocker, Michael Hohaus, Daniel Reim, Jennis Kandler, Michaela Müller, Alanna Ebigbo, Claudia Fuchs, Christiane J Bruns, Arnulf H Hölscher, Hauke Lang, Peter P Grimminger, Dani Dakkak, Yogesh Vashist, Sandra May, Siegfried Görg, Andre Franke, David Ellinghaus, Sara Galavotti, Lothar Veits, Josef Weismüller, Jens Dommermuth, Udo Benner, Thomas Rösch, Helmut Messmann, Brigitte Schumacher, Horst Neuhaus, Carsten Schmidt, Thaddäus T Wissinowski, Markus M Nöthen, Jing Dong, Jue-Sheng Ong, Matthew F Buas, Aaron P Thrift, Thomas L Vaughan, Ian Tomlinson, David C Whiteman, Rebecca Claire Fitzgerald, Janusz Jankowski, Michael Vieth, Andreas Mayr, Puya Gharahkhani, Stuart MacGregor, Ines Gockel, Claire Palles, Johannes Schumacher
Journal: Gut (2022)

Objective Oesophageal cancer (EC) is the sixth leading cause of cancer-related deaths. Oesophageal adenocarcinoma (EA), with Barrett’s oesophagus (BE) as a precursor lesion, is the most prevalent EC subtype in the Western world. This study aims to contribute to better understand the genetic causes of BE/EA by leveraging genome wide association studies (GWAS), genetic correlation analyses and polygenic risk modelling. Design We combined data from previous GWAS with new cohorts, increasing the sample size to 16 790 BE/EA cases and 32 476 controls. We also carried out a transcriptome wide association study (TWAS) using expression data from disease-relevant tissues to identify BE/EA candidate genes. To investigate the relationship with reported BE/EA risk factors, a linkage disequilibrium score regression (LDSR) analysis was performed. BE/EA risk models were developed combining clinical/lifestyle risk factors with polygenic risk scores (PRS) derived from the GWAS meta-analysis. Results The GWAS meta-analysis identified 27 BE and/or EA risk loci, 11 of which were novel. The TWAS identified promising BE/EA candidate genes at seven GWAS loci and at five additional risk loci. The LDSR analysis led to the identification of novel genetic correlations and pointed to differences in BE and EA aetiology. Gastro-oesophageal reflux disease appeared to contribute stronger to the metaplastic BE transformation than to EA development. Finally, combining PRS with BE/EA risk factors improved the performance of the risk models. Conclusion Our findings provide further insights into BE/EA aetiology and its relationship to risk factors. The results lay the foundation for future follow-up studies to identify underlying disease mechanisms and improving risk prediction.
SARS-CoV-2 vaccination in patients with GI and hepatobiliary carcinoma: a call for booster vaccination
Authors: Malte Benedikt Monin, Leona Baier, Moritz Berger, Jens Gabriel Gorny, Taotao Zhou, Robert Mahn, Farsaneh Sadeghlar, Christian Möhring, Kathrin van Bremen, Christoph Boesecke, Jürgen Rockstroh, Christian Strassburg, Anna-Maria Eis-Hübinger, Maria Agnes Gonzalez-Carmona
Journal: Gut (2022)
Abstracts OAS
Authors: Hayden Allen, James Hull, John O'hara, John Dickinson, Oliver Price
Journal: Allergy (2019)

Background: Fractional exhaled nitric oxide (FeNO) is a simple tool that has an established role in the assessment of airway inflammation in athletes.Specifically, FeNO provides information concerning asthma phenotypes, aetiology of respiratory symptoms, response to anti-inflammatory agents, course of disease and adherence to medication.It is recognised that FeNO can be influenced by a variety of external factors (e.g.atopic status, exercise, respiratory tract infection), however, there remains limited research concerning the impact of dietary nitrate ingestion.The primary aim of this study was therefore to evaluate the effect of
Assessment of Dyspnea in Acute Decompensated Heart Failure
Authors: Justin A. Ezekowitz, Adrian F. Hernandez, Christopher M. O'Connor, Randall C. Starling, Guy Proulx, Mason H. Weiss, Jeffrey A. Bakal, Robert M. Califf, John J.V. McMurray, Paul W. Armstrong
Journal: Journal of the American College of Cardiology (2012)
Functional repertoire convergence of distantly related eukaryotic plankton lineages abundant in the sunlit ocean
Authors: Tom O. Delmont, Morgan Gaia, Damien D. Hinsinger, Paul Frémont, Chiara Vanni, Antonio Fernandez-Guerra, A. Murat Eren, Artem Kourlaiev, Leo d'Agata, Quentin Clayssen, Emilie Villar, Karine Labadie, Corinne Cruaud, Julie Poulain, Corinne Da Silva, Marc Wessner, Benjamin Noel, Jean-Marc Aury, Colomban de Vargas, Chris Bowler, Eric Karsenti, Eric Pelletier, Patrick Wincker, Olivier Jaillon, Shinichi Sunagawa, Silvia G. Acinas, Peer Bork, Eric Karsenti, Chris Bowler, Christian Sardet, Lars Stemmann, Colomban de Vargas, Patrick Wincker, Magali Lescot, Marcel Babin, Gabriel Gorsky, Nigel Grimsley, Lionel Guidi, Pascal Hingamp, Olivier Jaillon, Stefanie Kandels, Daniele Iudicone, Hiroyuki Ogata, Stéphane Pesant, Matthew B. Sullivan, Fabrice Not, Karp-Boss Lee, Emmanuel Boss, Guy Cochrane, Michael Follows, Nicole Poulton, Jeroen Raes, Mike Sieracki, Sabrina Speich
Journal: Cell Genomics (2022)

Marine planktonic eukaryotes play critical roles in global biogeochemical cycles and climate. However, their poor representation in culture collections limits our understanding of the evolutionary history and genomic underpinnings of planktonic ecosystems. Here, we used 280 billion
Origins of Racial and Ethnic Bias in Pulmonary Technologies
Authors: Michael W. Sjoding, Sardar Ansari, Thomas S. Valley
Journal: Annual Review of Medicine (2022)

Understanding how biases originate in medical technologies and developing safeguards to identify, mitigate, and remove their harms are essential to ensuring equal performance in all individuals. Drawing upon examples from pulmonary medicine, this article describes how bias can be introduced in the physical aspects of the technology design, via unrepresentative data, or by conflation of biological with social determinants of health. It then can be perpetuated by inadequate evaluation and regulatory standards. Research demonstrates that pulse oximeters perform differently depending on patient race and ethnicity. Pulmonary function testing and algorithms used to predict healthcare needs are two additional examples of medical technologies with racial and ethnic biases that may perpetuate health disparities.
Omicron SARS-CoV-2 epidemic in England during February 2022: A series of cross-sectional community surveys
Authors: Marc Chadeau-Hyam, David Tang, Oliver Eales, Barbara Bodinier, Haowei Wang, Jakob Jonnerby, Matthew Whitaker, Joshua Elliott, David Haw, Caroline E. Walters, Christina Atchison, Peter J. Diggle, Andrew J. Page, Deborah Ashby, Wendy Barclay, Graham Taylor, Graham Cooke, Helen Ward, Ara Darzi, Christl A. Donnelly, Paul Elliott
Journal: The Lancet Regional Health - Europe (2022)

The Omicron wave of COVID-19 in England peaked in January 2022 resulting from the rapid transmission of the Omicron BA.1 variant. We investigate the spread and dynamics of the SARS-CoV-2 epidemic in the population of England during February 2022, by region, age and main SARS-CoV-2 sub-lineage.
Genetic predisposition and evolutionary traces of pediatric cancer risk: a prospective 5-year population-based genome sequencing study of children with CNS tumors
Authors: Ulrik Kristoffer Stoltze, Jon Foss-Skiftesvik, Thomas van Overeem Hansen, Anna Byrjalsen, Astrid Sehested, David Scheie, Torben Stamm Mikkelsen, Simon Rasmussen, Mads Bak, Henrik Okkels, Michael Thude Callesen, Jane Skjøth-Rasmussen, Anne-Marie Gerdes, Kjeld Schmiegelow, René Mathiasen, Karin Wadt
Journal: Neuro-Oncology (2022)

Abstract Background The etiology of central nervous system (CNS) tumors in children is largely unknown and population-based studies of genetic predisposition are lacking. Methods In this prospective, population-based study, we performed germline whole-genome sequencing in 128 children with CNS tumors, supplemented by a systematic pedigree analysis covering 3543 close relatives. Results Thirteen children (10%) harbored pathogenic variants in known cancer genes. These children were more likely to have medulloblastoma (OR 5.9, CI 1.6–21.2) and develop metasynchronous CNS tumors (P = 0.01). Similar carrier frequencies were seen among children with low-grade glioma (12.8%) and high-grade tumors (12.2%). Next, considering the high mortality of childhood CNS tumors throughout most of human evolution, we explored known pediatric-onset cancer genes, showing that they are more evolutionarily constrained than genes associated with risk of adult-onset malignancies (P = 5e−4) and all other genes (P = 5e−17). Based on this observation, we expanded our analysis to 2986 genes exhibiting high evolutionary constraint in 141,456 humans. This analysis identified eight directly causative loss-of-functions variants, and showed a dose-response association between degree of constraint and likelihood of pathogenicity—raising the question of the role of other highly constrained gene alterations detected. Conclusions Approximately 10% of pediatric CNS tumors can be attributed to rare variants in known cancer genes. Genes associated with high risk of childhood cancer show evolutionary evidence of constraint.
Development and prognosis of hepatocellular carcinoma in patients with diabetes
Authors: Takuma Nakatsuka, Ryosuke Tateishi
Journal: Clinical and Molecular Hepatology (2022)

The incidence of diabetes mellitus and hepatocellular carcinoma (HCC) has been increasing worldwide during the last few decades, in the context of an increasing prevalence of obesity and non-alcoholic fatty liver disease (NAFLD). Epidemiologic studies have revealed that patients with diabetes have a 2- to 3-fold increased risk of developing HCC, independent of the severity and cause of the underlying liver disease. A bidirectional relationship exists between diabetes and liver disease: advanced liver disease promotes the onset of diabetes, and HCC is an important cause of death in patients with diabetes; conversely, diabetes is a risk factor for liver fibrosis progression and HCC development, and may worsen the long-term prognosis of patients with HCC. The existence of close interconnections among diabetes, obesity, and NAFLD causes insulin resistance-related hyperinsulinemia, increased oxidative stress, and chronic inflammation, which are assumed to be the underlying causes of hepatocarcinogenesis in patients with diabetes. No appropriate surveillance methods for HCC development in patients with diabetes have been established, and liver diseases, including HCC, are often overlooked as complications of diabetes. Although some antidiabetic drugs are expected to prevent HCC development, further research on the optimal use of antidiabetic drugs aimed at hepatoprotection is warranted. Given the increasing medical and socioeconomic impact of diabetes on HCC development, diabetologists and hepatologists need to work together to develop strategies to address this emerging health issue. This article reviews the current knowledge on the impact of diabetes on the development and progression of HCC.
Trends in Severe Maternal Morbidity in the US Across the Transition to <i>ICD-10-CM/PCS</i> From 2012-2019
Authors: Ashley H. Hirai, Pamela L. Owens, Lawrence D. Reid, Catherine J. Vladutiu, Elliott K. Main
Journal: JAMA Network Open (2022)

Surveillance of severe maternal morbidity (SMM) is critical for monitoring maternal health and evaluating clinical quality improvement efforts.To evaluate national and state trends in SMM rates from 2012 to 2019 and potential disruptions associated with the transition to International Classification of Diseases, 10th Revision, Clinical Modification and Procedure Coding System (ICD-10-CM/PCS) in October 2015.This repeated cross-sectional analysis examined delivery hospitalizations from 2012 through 2019 in the Healthcare Cost and Utilization Project's National Inpatient Sample and State Inpatient Databases, an all-payer compendium of hospital discharge records from community, nonrehabilitation hospitals. Trends were evaluated using segmented linear binomial regression models that allowed for discontinuities across the ICD-10-CM/PCS transition. Analyses were completed from April 2021 through March 2022.Time, ICD-10-CM/PCS coding system, and state.SMM rates, excluding blood transfusion, per 10 000 delivery hospitalizations, overall and by indicator.From 2012 to 2019, there were 5 964 315 delivery hospitalizations in the national sample representing a weighted total of 29.8 million deliveries with a mean (SD) maternal age of 28.6 (5.9) years. SMM rates increased from 69.5 per 10 000 in 2012 to 79.7 per 10 000 in 2019 (rate difference [RD], 10.2; 95% CI, 5.8 to 14.6) without a significant change across the ICD-10-CM/PCS transition (RD, -3.2; 95% CI, -6.9 to 0.6). Of 20 SMM indicators, rates for 10 indicators significantly increased while 3 significantly decreased; 5 of these changes were associated with ICD-10-CM/PCS transition. Acute kidney failure had the largest increase, from 6.4 to 15.3 per 10 000 delivery hospitalizations (RD, 8.9; 95% CI, 7.5 to 10.3) with no change associated with ICD transition (RD, -0.1; 95% CI, -1.2 to 1.1). Disseminated intravascular coagulation had the largest decrease from 31.3 to 21.2 per 10 000 (RD, 10.2; 95% CI, -12.8 to -7.5), with a significant drop associated with ICD transition (RD, -7.9; 95% CI, -10.2 to -5.6). State SMM rates significantly decreased for 1 state and significantly increased for 21 states from 2012 to 2019 and associations with ICD transition varied.In this cross-sectional study, overall US SMM rates increased from 2012 to 2019, which was not associated with the ICD-10-CM/PCS transition. However, data for certain indicators and states may not be comparable across coding systems; efforts are needed to understand SMM increases and state variation.
National Prevalence of Excessive Screen Exposure Among Chinese Preschoolers
Authors: Jing Hua, Jinhong Xie, Charlie Baker, Wenchong Du
Journal: JAMA Network Open (2022)

This cohort study uses data from the Chinese National Cohort of Motor Development to evaluate the national prevalence of and factors associated with excessive screen exposure among Chinese preschoolers aged 3 to 5 years.
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine
Authors: Ramin Sedaghat Herati, David A. Knorr, Laura A. Vella, Luisa Victoria Silva, Lakshmi Chilukuri, Sokratis A. Apostolidis, Alexander C. Huang, Alexander Muselman, Sasikanth Manne, Oliva Kuthuru, Ryan P. Staupe, Sharon A. Adamski, Senthil Kannan, Raj K. Kurupati, Hildegund C. J. Ertl, Jeffrey L. Wong, Stylianos Bournazos, Suzanne McGettigan, Lynn M. Schuchter, Ritesh R. Kotecha, Samuel A. Funt, Martin H. Voss, Robert J. Motzer, Chung-Han Lee, Dean F. Bajorin, Tara C. Mitchell, Jeffrey V. Ravetch, E. John Wherry
Journal: Nature Immunology (2022)
Systemic induction of senescence in young mice after single heterochronic blood exchange
Authors: Ok Hee Jeon, Melod Mehdipour, Tae-Hwan Gil, Minha Kang, Nicholas W. Aguirre, Zachery R. Robinson, Cameron Kato, Jessy Etienne, Hyo Gyeong Lee, Fatouma Alimirah, Vighnesh Walavalkar, Pierre-Yves Desprez, Michael J. Conboy, Judith Campisi, Irina M. Conboy
Journal: Nature Metabolism (2022)
The metabolic crossroad of the adolescent athlete: achieving peak bone mass during athletic development
Authors: Irfan Ahmed, Raj Amarnani, Corinne Fisher
Journal: British Journal of Sports Medicine (2022)

<h3>Objective</h3> To explore health-seeking behaviour and experiences of undocumented migrants (UMs) in general practice in relation to mental health problems. <h3>Design</h3> Qualitative study using semistructured interviews and thematic analysis. <h3>Participants</h3> 15 UMs in the Netherlands, varying in age, gender, country of origin and education; inclusion until theoretical saturation was reached. <h3>Setting</h3> 4 cities in the Netherlands. <h3>Results</h3> UMs consider mental health problems to be directly related to their precarious living conditions. For support, they refer to friends and religion first, the general practitioner (GP) is their last resort. Barriers for seeking help include taboo on mental health problems, lack of knowledge of and trust in GPs competencies regarding mental health and general barriers in accessing healthcare as an UM (lack of knowledge of the right to access healthcare, fear of prosecution, financial constraints and practical difficulties). Once access has been gained, satisfaction with care is high. This is primarily due to the attitude of the GPs and the effectiveness of the treatment. Reasons for dissatisfaction with GP care are an experienced lack of time, lack of personal attention and absence of physical examination. Expectations of the GP vary, medication for mental health problems is not necessarily seen as a good practice. <h3>Conclusions</h3> UMs often see their precarious living conditions as an important determinant of their mental health; they do not easily seek help for mental health problems and various barriers hamper access to healthcare for them. Rather than for medication, UMs are looking for encouragement and support from their GP. We recommend that barriers experienced in seeking professional care are tackled at an institutional level as well as at the level of GP.