tbuckley/cabot-search huggingface dataset:
Collagenous Colitis
Authors: HUGO RAMS
Journal: Annals of Internal Medicine (1987)

Two hypotheses have been proposed to explain the pathogenesis and cause of the increased subepithelial collagen deposition that occurs in patients with collagenous colitis, a rare disease of unknown cause. One hypothesis considers an inflammatory origin, and the other, a local abnormality of collagen synthesis. An analysis of clinical, endoscopic, and histologic findings from one of our patients and from previously published cases suggests that collagenous colitis is a form of inflammatory bowel disease characterized by localization of the initial injury to the superficial subepithelial zone and with subsequent fibrosis in that area. The data show a spectrum of clinical and histologic changes that represent different stages in the evolution of the inflammatory process.
Remembered Pain
Authors: Robert S. McKelvey
Journal: JAMA (1988)

I was recently called to consult on a severely depressed, middle-aged Vietnam veteran. The resident on the case wondered aloud if the man's symptomatology—anxiety, depression, and recurrent terrifying nightmares of combat—could really be related to events of long ago. Would not time have healed his wounds? As I tried to explain to her the timelessness of emotional pain that has not been well integrated into one's experience, a memory suddenly thrust itself on me. It was Easter Sunday—cold, overcast, and rainy—an Easter Sunday 18 years ago northwest of Da Nang in what was then South Vietnam. I was in church, my spirits buoyed by the beauty and hope of Easter music and the realization that I would soon be going home. My thoughts were interrupted by a touch on my shoulder and a whispered voice: "Captain, there's been an accident in the village. The C.O. wants you to go take
Acute Effects of Polychlorinated Biphenyl-Containing and -Free Transformer Fluids on Rat Testicular Steroidogenesis
Authors: Silvana A. Andric, Tatjana S. Kostic, Snezana M. Dragisic, Nebojsa L. Andric, Stanko S. Stojilkovic, Radmila Z. Kovacevic
Journal: Environmental Health Perspectives (2000)

Polychlorinated biphenyl (PCB)-based transformer fluids belong to a class of environmentally persistent mixtures with known toxic effects. Here, we studied the acute effects of Askarel (which contains Aroclor 1260) and two substitute transformer fluids (the silicone oil-based DC561 and the mineral oil-based ENOL C) on rat testicular steroidogenesis. Single intraperitoneal (ip; 10 mg/kg body weight) or bilateral intratesticular (itt; 25 microg/testis) injections of Askarel markedly decreased serum androgen levels 24 hr after administration. In acute testicular cultures from these animals, chorionic gonadotropin-stimulated progesterone and androgen productions were severely attenuated. When itt was injected or added in vitro, Askarel inhibited 3ss-hydroxysteroid dehydrogenase (3ssHSD), stimulated 17[alpha]-hydroxylase/lyase (P450c17), and did not affect 17ss-hydroxysteroid dehydrogenase in testicular postmitochondrial fractions. The ip-injected Askarel did not affect 3ssHSD, but inhibited P450c17, suggesting that a more intensive metabolism of peripherally injected Askarel reduces the circulating levels of active ingredients below the threshold needed for inhibition of 3ssHSD and generates a derivative that inhibits P450c17. In contrast to Askarel, itt-injection (25 microg/testis) of DC561 and ENOL C did not affect in vivo and in vitro steroidogenesis. These findings show the acute effects of Askarel, but not silicone and mineral oils, on testicular steroidogenesis.
FDA Tackles Underage E-cigarette Use
Journal: Cancer Discovery (2018)

In recent weeks, the FDA has taken steps to address underage use of e-cigarettes: The agency has identified and warned retailers selling to minors, issued warning letters to companies selling e-cigarette cartridges in adolescent-appealing packaging, and requested information from e-cigarette companies. The steps are part of the FDA's ongoing effort to prevent middle- and high-school students from using e-cigarette products.
State Medical Associations and Examinations and Licensure
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetic Testing for Children and Adolescents
Authors: Robert Roger Lebel
Journal: JAMA (1995)

<h3>To the Editor.</h3> —We applaud the contribution of Dr Wertz and colleagues<sup>1</sup>for their thought-provoking discussion of the issues involved in genetic testing of children and adolescents. We are impressed by the constructive approach to articulating "categories, based on utility," and the distribution of responsibilities among parents, children, and professionals. The article is useful in promoting discussion of these important and growing concerns. It appeared 3 days before a long-planned, all-day meeting of our group (Subcommittee on Ethical and Legal Issues of the Great Lakes Regional Genetics Group) to discuss the same subject in hope of drafting a position statement. We propose some points to help advance the discussion. There is need for more complete exploration of the following: (1) parents' fundamental rights and duties of decision making with respect to genetic testing of their minor children; (2) circumstances and concerns prompting requests for genetic testing of minors (usually
Intravascular Erythrophagocytosis
Authors: Henry D. Friedman
Journal: JAMA (1991)

A previously healthy 8-year-old boy developed severe hemolytic anemia several days after uneventful chickenpox. He presented shortly after cold exposure with a hematocrit of 0.12, hemoglobinuria, and a white blood cell count of 26 × 10<sup>9</sup>/L. His presentation and laboratory findings strongly suggested postinfectious cold agglutinin disease of IgM type.<sup>1(pp526-527)</sup>The peripheral blood film at admission (Figure) was striking for erythrophagocytosis by 9% of 22 × 10<sup>9</sup>/L segmented neutrophils, erythrocyte agglutination, and a rosette-like arrangement of erythrocytes about segmented neutrophils. Intravascular erythrophagocytosis appears to serve as an auxiliary means of sequestering and destroying erythrocytes and occurs during excessive opsonization of intravascular erythrocytes<sup>1(pp98-101)</sup>and when splenic and hepatic macrophages are overwhelmed.<sup>2,3</sup>Nonneoplastic diseases associated with intravascular erythrophagocytosis include two types of disorders: (1) those with an abundance of altered erythrocytes (as in sickle cell crisis<sup>4</sup>and Heinz-body hemolytic anemia<sup>5,6</sup>) and (2) those
President's Address
Authors: F. M.  POTTENGER
Journal: Annals of Internal Medicine (1933)

Article1 June 1933President's AddressF. M. POTTENGER, M.D., F.A.C.P.F. M. POTTENGER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-12-1517 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOne of the greatest honors which can come to an internist in America is to have his colleagues entrust to his care and guidance the destinies of The American College of Physicians, for this organization stands for the highest ideals and the noblest sentiments which actuate medical men in the pursuit of knowledge and in the application of medical facts to the prevention and cure of disease, and to the alleviation of suffering. A year ago, on assuming the duties of President, I thanked you warmly for the confidence which you reposed in me, and tonight, I again wish to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Monrovia, California*Read at the Seventeenth Annual Clinical Session of the American College of Physicians, Montreal, Canada, February 6-10, 1933. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1933Volume 6, Issue 12Page: 1517-1534 ePublished: 1 December 2008 Issue Published: 1 June 1933 PDF downloadLoading ...
Reporting on Statistical Methods To Adjust for Confounding
Journal: Annals of Internal Medicine (2002)

Summaries for Patients15 January 2002Reporting on Statistical Methods To Adjust for ConfoundingAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-2-200201150-00004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Research projects often try to show that a condition (such as age) has a strong association with a health care outcome (such as death from heart disease). Confounding occurs when the health care outcome is influenced by factors other than the one that a researcher thinks is the most important. These factors are called confounders. For example, suppose that a researcher was studying whether pregnant women who drink coffee are more likely to have small babies than are women who do not drink coffee. Now suppose that the ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled "Reporting on Statistical Methods To Adjust for Confounding: A Cross-Sectional Survey." It is in the 15 January 2002 issue of Annals of Internal Medicine (volume 136, pages 122-126). The authors are M Müllner, H Matthews, and DG Altman.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoReporting on Statistical Methods To Adjust for Confounding: A Cross-Sectional Survey Marcus Müllner , Hugh Matthews , and Douglas G. Altman Metrics 15 January 2002Volume 136, Issue 2Page: I-47KeywordsAlcoholsCoffeeEpidemiologyHealth careHealth statisticsLow birth weightPatientsPregnancyPrevention, policy, and public healthStatistical methods ePublished: 15 January 2002 Issue Published: 15 January 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Leading Cases
Authors: Bruce Nortell
Journal: JAMA (1977)

EVERY week there are many court decisions that have an impact on the practice of medicine. These decisions are currently reported, in summary, in<i>The Citation</i>, a newsletter published twice a month by the office of the General Counsel, American Medical Association. Some of these decisions are of such special importance that they deserve the wider publicity that can be obtained through the pages ofThe Journal. Trial court decisions, which are of little precedent value and are subject to reversal, are omitted. Selected decisions are usually restricted to those of the highest state or federal court. It should be remembered, however, that a decision by a court in one state is not necessarily binding elsewhere. <h3>Administrative Professional Services</h3> The professional services of a physician may include administrative activities, the Wisconsin Supreme Court has ruled.<sup>1</sup>This is an important decision because a physician may wish to bring suit to
MEAT AND TWO VEGETABLES
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A tax reform strategy to deal with the uninsured
Authors: S. M. Butler
Journal: JAMA (1991)

The high level of uninsurance in the United States is due in large measure to the tax treatment of health care, which is based on the tax exclusion for company-provided plans. Correcting the perverse incentives for providers and patients resulting from this tax treatment is the crucial step to creating a national health care system that is affordable and efficient. The Heritage Foundation proposal calls for the elimination of the current tax exclusion and its replacement with a system of refundable tax credits for the purchase of health insurance and medical services. (<i>JAMA</i>. 1991;265:2541-2544)
Schlafmittel-Therapie.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SUTURES, DISASTERS, AND TONSILS
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical schools in the United States and Canada
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Migraine
Authors: SAUL B. GILSON
Journal: Annals of Internal Medicine (1980)

Ad Libitum1 February 1980MigraineSAUL B. GILSON, M.D.SAUL B. GILSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-2-259_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIMy eyes dim dazzledForecast mockery of mindImpediment of witA sullen fitAnd hammers come behind.With sense obscuredAnd strange mind dullI'm stranger to myselfFrom sluggish thoughtComes slower wordFrom softer touchA thornQuartets and liederAre irksome heardAnd poems thwart stillborn.IIThe same sky blue The same hill woodedThe camera snaps a chartThe identical sceneStill sunlight floodedMists in the painter's art.IIIAnd death claims the voice of the poemBleak tree on light sky moves me notA lapse in the sense dulls Proust's image... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1980Volume 92, Issue 2_Part_1Page: 259-259KeywordsChartsMigraineTouch ePublished: 1 December 2008 Issue Published: 1 February 1980 PDF downloadLoading ...
Dermatology
Authors: J. S. Dover
Journal: JAMA (1989)

Two topical medications have stimulated a great deal of attention among physicians, the public, and the media: minoxidil and tretinoin, both of which are aimed at retarding or reversing the inevitable aging process. Topical 2% minoxidil is the first medical treatment documented to stimulate hair growth in male pattern baldness (androgenetic alopecia). Enthusiasm for this treatment seems to be exceeding its demonstrated clinical effectiveness. Studies of the ability of topical minoxidil to grow terminal (coarse, dark) scalp hair have been ongoing since 1979, when oral minoxidil was noted to induce hypertrichosis in patients treated for hypertension. There is no doubt that topical minoxidil is safe and can induce the growth of terminal hairs in some balding men. However, the more important question is not whether the hair growth is statistically significant but whether it causes satisfactory cosmetic improvement. Topical minoxidil solution, in concentrations ranging from 1% to 5%, has been
Reply
Authors: Jacqueline G. O’Leary, K. Rajender Reddy, Florence Wong, Guadalupe Garcia‐Tsao, Patrick S. Kamath, Jasmohan S. Bajaj
Journal: Hepatology (2018)

Potential conflict of interest: Nothing to report. We thank Drs. Mattos and Mattos for their letter regarding our recent study in Hepatology validating the North American Consortium for the Study of End‐stage Liver Disease (NACSELD) Acute‐on‐Chronic Liver Failure (ACLF) score.(1) However, we feel the need to comment on several of their points. First, they espouse that the Chronic Liver Failure Consortium (CLIF‐C) definition of ACLF is more sensitive for the diagnosis of ACLF because that definition was applicable to 30% of hospitalized patients with "acute" decompensation, while the NACSELD‐ACLF score was applicable to 10% of our admitted patients with cirrhosis. "Acute decompensation" is a poorly defined term applicable to hospitalized patients with decompensated cirrhosis in the absence of organ failure. Of note, the NACSELD‐ACLF score was applicable to 17% of infected patients. It is also important to highlight that just because a definition is applicable to more patients, it does not make it better or more useful. In fact, a definition that culls out a highly selected group may be more applicable at the bedside or in clinical trials of new agents. Second, we thank them for highlighting our discussion of using the NASCELD‐ACLF score when determining futility. We believe that the use of NACSELD‐ACLF is a tool for clinicians to objectively use when determining futility; however, we must highlight that it should never be used in isolation. When applying CLIF‐C, Levesque et al. clearly showed unacceptable 90‐day survival (approximately 60%) posttransplant in patients with ACLF‐3 who were transplanted.(3) Whereas Artru et al. showed a similar prognosis among all grades of ACLF. However, half the patients had septic shock and were transplanted after resolution of shock, and the number of organ failures had improved before transplantation.(4) One would expect that increasing grades of ACLF would be associated with worse prognosis both with and without transplantation, and therefore there is room for improvement beyond CLIF‐C to predict futility of transplantation, which NACSELD‐ACLF may fill. Third, it will be important for the near future to compare the utility of NACSELD‐ACLF and CLIF‐C in a head‐to‐head comparison to determine where both scores fit into the clinician's toolbox for prognostication.