tbuckley/cabot-search huggingface dataset:
Interstitial high dose rate (HDR) brachytherapy under local anesthesia for early stage prostate cancer
Authors: G. Vallabhan, R. Mark, R. Akins, P. Anderson, T. Neumann, M. Nair
Journal: Journal of Clinical Oncology (2005)

4721 Background: Transrectal Ultrasound (TRUS) guided interstitial implant for prostate cancer using Low Dose Rate (LDR) and High Dose Rate (HDR) techniques has been reported with early results comparing very favorably to external beam radiation therapy. TRUS interstitial implant of the prostate has been traditionally performed under general or spinal anesthetic in an operating room. We report our results with a technique performed under local anesthesia in a Department procedure room. Methods: Patients with T1 and T2 localized prostate cancer were judged to be candidates for TRUS guided interstitial implant. Results: Between 2002 and 2004, 187 TRUS guided prostate implants were performed under local anesthesia. Conscious sedation consisted of intravenous Morphine (12–22 mg) and Versed (6–14 mg), intravenous Demerol (50–175 mg) and Versed (3–12 mg). Local anesthetic was given with a mixture of 1% Lidocaine, 0.25% Marcaine, 1:100,000 Epinephrine, and 4% Sodium Bicarbonate neutralizing solution (20–120 cc). Local anesthesia was given to a 5 x 5 cm perineal area to a depth of 10 cm under TRUS guidance. The implants were placed under mobile multi-plane prostate template (Radiation Therapy Products Prostate Template) guidance using from 3 to 4 planes, and 12 to 22 needles. Needle spacing was 1.0 cm. The implant procedure included sigmoidoscopy and cystoscopy. Median implant time was 45 minutes (range: 30 to 150 minutes). HDR treatment was given using the Nucletron afterloading system. The implant volume received 2,250 cGy in 3 fractions prescribed to the 100% Isodose line, given over 24 hours. Urethral dose points (12–16) were followed, and limited to ≤ 105% of the prescription dose. The procedure was well tolerated, with all patients having completed the procedure. One patient developed respiratory suppression, and required reversal with Narcan. He recovered uneventfully. Otherwise, there have been no acute complications to date. Conclusions: TRUS interstitial implant of the prostate under local anesthesia is feasible. Implant time and complications compare favorably to general or spinal anesthetic technique. No significant financial relationships to disclose.
News in brief
Journal: BMJ (2009)

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Letter: Wartime penicillin.
Authors: Andrew Hua, Priscilla Kincaid-Smith
Journal: BMJ (1974)

In this crossover study it was possible to achieve very satisfactory control of the blood pressure with few side effects during each treatment period in which a vasodilator (either prazosin or hydrallazine) was com- bined with a beta-adrenergic blocking agent and a thiazide.Blood pressure control had not been satisfactory before addition of the vasodilator capsules.All blood pressures were estimated with the London School of Hygiene and Tropical Medicine sphygmomanometer.-Weare, etc.,
THE DIFFICULTIES OF DIETARY REFORMS
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: R. W. CRAIG
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article BOOK REVIEWS Get access Tumour Suppressor Genes, the Cell Cycle and Cancer A. J. Levine , ed . Plainview, N.Y. : Cold Spring Harbor Lab. Press , 1992 . 225 pp., illus. $60. Cancer Surveys, Vol. 12. ISBN 0-87969-369-X RUTH W. CRAIG, PH.D. RUTH W. CRAIG, PH.D. The Johns Hopkins University School of Medicine725 N. Wolfe St. Baltimore, MD 21205-2185 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 23, 2 December 1992, Pages 1829–1830, https://doi.org/10.1093/jnci/84.23.1829-a Published: 02 December 1992
Bartenders' Pulmonary Function After Establishment of a Smoke-Free Workplace—Reply
Authors: Mark D. Eisner, Paul D. Blanc
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ESGE Newsletter
Journal: Endoscopy (2016)

Endoscopy in patients on antiplatelet or anticoagulant therapy, including direct oral anticoagulants: British society of Gastroenterology (BSG) and European society of Gastrointestinal Endoscopy (ESGE) guidelines from Andrew Veitch et al. Please read page 358 – 402 in this issue of Endoscopy Free access at www.esge.com
RUBELLA RETINITIS
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manuscripts Approved for JNCI, June 1 to July 1, 1965
Journal: JNCI Journal of the National Cancer Institute (1965)

Journal Article Manuscripts Approved for JNCI, June 1 to July 1, 1965 Get access JNCI: Journal of the National Cancer Institute, Volume 35, Issue 2, August 1965, Pages 379–380, https://doi.org/10.1093/jnci/35.2.379-a Published: 01 August 1965
From the Centers for Disease Control and Prevention. Hantavirus pulmonary syndrome, United States 1993
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5579: Myocardial Infarction, Clinical Characteristics and Prognosis across Five Renal Function Stages - Data from the Register of Information and Knowledge about Swedish Heart Intensive Care Admissions (RIKS-HIA)
Authors: Karolina Szummer, Pia Lundman, Stefan Jacobson, Staffan Schön, Johan Lindbäck, Ulf Stenestrand, Lars Wallentin, Tomas Jernberg
Journal: Circulation (2008)

Assess clinical characteristics, presentation and prognosis following a myocardial infarction (MI) at different degrees of renal insufficiency. Nearly all consecutive patients in Sweden with MI treated at a coronary care unit between 2003–2006 and who had either known creatinine or received dialysis (n=58496, 90.4% of entire cohort) were followed. Glomerular filtration rate (eGFR) was estimated with the Modification of Diet in Renal Disease formula and staged according to the National Kidney Foundation definition. Cox regression analysis adjusting for 30 variables including baseline characteristics, symptoms on admission, ECG-pattern, reperfusion therapy and discharge medication was used to assess mortality with eGFR both as a continuous and categorical variable. Patients with declining renal function differed by being older and having more comorbidites such as diabetes, hypertension and prior MI. Fewer patients with kidney failure presented with chest pain compared to those with normal eGFR≥90 ml/min/m2 (66.2% versus 90.2%). They had a non-ST-elevation MI more often (67.7% versus 55.7%) and clinical heart failure (45.0% versus 10.7%) on admission. Overall, at 30 days and 1 year, 8.5% and 16.4% patients had died. After adjustment, 30-day and 1-year mortality was significantly higher in those with more advanced renal insufficiency (Table ). For every 10 ml decrease in eGFR 30-day mortality increased by 3.1% (95% CI 1.00 –1.06, p=0.025), whereas 1-year mortality increased exponentially. Patients with renal insufficiency differ in presentation pattern for a MI. Although 30-day mortality increases linearly with worsening renal function, 1-year mortality differs by increasing exponentially, leading to extremely high mortality rates in those with severe renal insufficiency. Research into disease mechanisms and advances in therapies are needed to enhance outcome. Mortality following a MI across renal function groups
Abstract 1253: Increased Red Blood Cell Distribution Width is Associated with Greater Risk of All-Cause, Cardiovascular and Non-Cardiovascular Mortality in a Large Community-Based Cohort
Authors: Todd S Perlstein, Jennifer Weuve, Marc A Pfeffer, Joshua A Beckman
Journal: Circulation (2008)

Background: The red cell distribution width (RDW), a measure of red cell size heterogeneity (anisocytosis), is a newly recognized risk marker in patients with CVD. It is unknown whether RDW is associated with mortality in the general population. Methods and results: We examined the association of RDW with mortality risk among 14,953 adult participants in the Third National Health and Nutrition Examination Survey (1988 –1994), a representative sample of the United States population. Over a geometric mean of 8.3 years, 2,372 deaths occurred. Age-standardized mortality rates, excepting external-cause (i.e. accidental) deaths, increased across RDW quintiles (figure ). A one standard deviation increment in RDW (0.98) was associated with a 21% greater risk of all-cause (HR 1.21, 95% CI 1.15–1.26) and cardiovascular mortality (HR 1.21, 95% CI 1.13–1.29) after multivariable adjustment including hemoglobin level. RDW was also independently associated with risk of death due to cancer (HR 1.21, 95% CI 1.12–1.30) and chronic lower respiratory disease (HR 1.31, 95% CI 1.14 –1.52). Only age exceeded the statistical strength of RDW’s association with all-cause and cardiovascular mortality; only age and smoking were more strongly associated with cancer and chronic lower respiratory disease mortality. Conclusions: We found that higher RDW was strongly predictive of increased risk of all-cause, cardiovascular, and non-cardiovascular mortality in this large, community-based sample. Study of anisocytosis may therefore yield broad pathophysiological insights, and measurement of RDW may contribute to patient risk assessment.
"Surveyor opinion" development and implementation in Monroe County, New York
Authors: C. Cristo
Journal: JAMA (1966)

The development of a proper method for studying patterns of bed utilization has been difficult and slow, primarily because there is heavy reliance on "surveyor" or "viewer" opinion, which is judgmental and therefore not easily analyzed. The Medical Society of the County of Monroe, New York, has had an active program of utilization investigation and education over the past five years. Its physician members have taken part in a number of coordinated local studies as "surveyors" both in and out of the county area. The value of this approach becomes obvious when one considers not only the gathering of statistical data but the exposure of the physician "observer" or "surveyor" to the peculiar problems of utilization review. In October 1960, Dr. Hobard L. Boyd, then president of the Medical Society of the County of Monroe, initiated the program which led to the establishment of the Monroe County Medical Society's Community
A Comparison of Lithium and T&lt;char aid="99818416" id="sub"&gt;3&lt;/char&gt; Augmentation Following Two Failed Medication Treatments for Depression: A STAR*D Report
Authors: Andrew Nierenberg
Journal: American Journal of Psychiatry (2006)

Objective: More than 40% of patients with major depressive disorder do not achieve remission even after two optimally delivered trials of antidepressant medications. This study compared the effectiveness of lithium versus triiodothyronine (T 3 ) augmentation as a third-step treatment for patients with major depressive disorder. Method: A total of 142 adult outpatients with nonpsychotic major depressive disorder who had not achieved remission or who were intolerant to an initial prospective treatment with citalopram and a second switch or augmentation trial were randomly assigned to augmentation with lithium (up to 900 mg/day; N=69) or with T 3 (up to 50 μg/day; N=73) for up to 14 weeks. The primary outcome measure was whether participants achieved remission, which was defined as a score ≤7 on the 17-item Hamilton Depression Rating Scale. Results: After a mean of 9.6 weeks (SD=5.2) of treatment, remission rates were 15.9% with lithium augmentation and 24.7% with T 3 augmentation, although the difference between treatments was not statistically significant. Lithium was more frequently associated with side effects (p=0.045), and more participants in the lithium group left treatment because of side effects (23.2% versus 9.6%; p=0.027). Conclusions: Remission rates with lithium and T 3 augmentation for participants who experienced unsatisfactory results with two prior medication treatments were modest and did not differ significantly. The lower side effect burden and ease of use of T 3 augmentation suggest that it has slight advantages over lithium augmentation for depressed patients who have experienced several failed medication trials.
Popliteal artery entrapment syndrome
Authors: G. R. Turner
Journal: JAMA (1969)

This is the seventh reported case of popliteal artery entrapment due to an anomalous course of the popliteal artery in relation to the medial head of the gastrocnemius muscle. This syndrome should be suspected in young male patients who have unilateral intermittent claudication without evidence of generalized arteriosclerosis. Characteristic arteriographic findings are (1) an abnormal segmental occlusion of the popliteal artery, and (2) medial deviation of the artery. Transection of the medial head of the gastrocnemius muscle and thromboendarterectomy or replacement of the popliteal artery is curative.
Drugs and Cancer Risk
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnostic Paracentesis
Authors: Ernest E. Moore
Journal: JAMA (1978)

<h3>To the Editor.—</h3> The Surgical Service at Denver General Hospital has been aware of the potential complications of abdominal paracentesis. Although the primary use of this procedure by us has been in patients with abdominal trauma, the technique we use could be applicable to patients with medical indications. Our method is particularly appropriate in those with previous surgery, gastrointestinal distension, or clotting abnormalities. The interesting review of serious "Complications of Diagnostic Paracentesis in Patients With Liver Disease" by Mallory and Schaefer (239:628, 1978) is a valuable contribution, as it emphasizes that paracentesis is not a benign procedure. In high-risk patients with adhesions from previous surgery, we believe that the "mini lap technique"<sup>1,2</sup>is a safer method. The peritoneum is opened in the midline under direct visualization, and a dialysis catheter is advanced carefully into the abdominal cavity. In cases where hemorrhage is a potential complication, optimal hemostasis is best achieved
Incorrect Dosage
Journal: JAMA (1982)

An error occurred in the CLINICAL NOTE "Neutropenia Associated With Maprotiline" published in the Aug 20 issue ofThe Journal(1982;248:871). In the "Report of a Case" section, the last sentence of the first paragraph should have read as follows: "Her only other medication was thyroid extract at a dosage of 0.2 [not 6.2] g/day for hypothyroidism."
TWO SMALL OUTBREAKS OF TYPHOID FEVER PROBABLY DUE TO A CARRIER
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gonorrheal conjunctivitis an old disease returned
Authors: T. Hansen
Journal: JAMA (1966)

<h3>To the Editor:—</h3> There has been a serious increase in venereal disease in this country, with gonorrhea as well as syphilis occurring more frequently especially in young adults.<sup>1</sup>The complications of gonorrhea, including the potentially blinding conjunctivitis, may be expected to increase in frequency parallel to this increased genitourinary disease. Gonorrheal conjunctivitis is not common, considering the incidence of genital gonorrhea, occurring in one in 700 or 800 cases.<sup>2</sup>The transmission of bacteria to the eye is usually from the genital organs via the unwashed hands in adults, or by direct inoculation of the eye during passage through the infected cervix in newborn infants. Many physicians, including some ophthalmologists, have never seen a case of gonorrheal ophthalmia. The disease begins as a hyperacute purulent conjunctivitis, usually unilateral, but frequently becoming bilateral after a few days. Clinical manifestations vary slightly according to age, the adult form usually being the
Hazards in the use of diphencyprone
Authors: A. Adisesh, M. Beck, N.M. Cherry
Journal: British Journal of Dermatology (1997)

Journal Article Hazards in the use of diphencyprone Get access A. Adisesh, A. Adisesh Centre for Occupational Health, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, U.K. Search for other works by this author on: Oxford Academic Google Scholar M. Beck, M. Beck Centre for Occupational Health, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, U.K. Search for other works by this author on: Oxford Academic Google Scholar N.M. Cherry N.M. Cherry Centre for Occupational Health, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 136, Issue 3, 1 March 1997, Page 470, https://doi.org/10.1111/j.1365-2133.1997.tb14974.x Published: 01 March 1997