tbuckley/cabot-search huggingface dataset:
Actinomycosis Hominis
Authors: T. D. Acland
Journal: BMJ (1886)

What I subequently learnt, nmade me yet more certain that the attack in the foot was, as diagnosed at the time by her sur- geon, acute gout.The pain began in the middle of the night, and after an unwonted supper on beef.The nuinbness of the foot wa probably due to the extreme severity of the pain in the tarsal joint which was inflamed.I have known a cue of acute gout of the shoulder-joint mistaken for paralysis of the unper extre- mity, on account of the helplessness and numbness of the limb, which were induced, I believe, by the extreme severity of the pain in the joint The peculiarities of the attack; the coldness of the part, instead of heat; and its lividity, instead of redness, were, no doubt, due to the previously exiRting peculiarities in Mliss B.'s circulation.Turgescence of the venous system is, unlder many conditions, a noticeable feature in gout.We may ask the question, whether, in Miss B. 'a case, the gout- tendency had anytlling to do with She production of the general asphyxia of the limbs.I saw, some years ago, a gentlemian, a mem- ber of our own professioin, aged about 65, in whom there was
Heterogeneity in hepatic transport of somatostatin analog octapeptides
Authors: G Fricker
Journal: Hepatology (1994)

Hepatic transport of the synthetic somatostatin analog octreotide—SMS 201–995, -Throl—and its novel derivative N-α-(α-D-glucosyl(1–4)-1-deoxy-D-fructosyl)-octreotide—SDZ CO-611, N-α-(α-D-glucosyl(1–4)-1-deoxy-D-fructosyl)--Throl—was studied. In rats SMS 201–995 showed a plasma elimination half-life of 1.2 ± 0.2 hr; that of SDZ CO-611 was 1.9 ± 0.3 hours. Within 120 min 66% of a mesenterically injected 4.4-nmol dose of SMS 201–995 was excreted in bile, but only 5.3% of SDZ CO-611 was excreted in bile. Biliary concentration of SMS 201–995 showed a maximum enrichment of 540-fold ± 75-fold over peripheral blood concentration, indicating hepatic transport mechanisms different from simple diffusion. Comparison of plasma profiles of both peptides after mesenteric and femoral administration demonstrated the relative importance of hepatic extraction for SMS 201–995 but not for SDZ CO-611. The mode of extraction was studied by means of multiple-indicator dilution in isolated perfused rat liver, with inulin as nonpermeable marker. Ratio plots, ln([inulin]/[peptide]) vs. time, exhibited decreasing slopes for SMS 201–995, suggesting very rapid binding to hepatocyte membranes. The slope of the ratio plot of (inulin/SDZ CO-611) was almost zero even at low doses (down to 0.2 μg), implying mainly extracellular distribution and nonhepatic elimination. Binding assays indicated the absence of somatostatin receptors in sinusoidal hepatocyte membranes. However, SMS 201–995 and SDZ CO-611 bound with high affinity to somatostatin receptors in rat cortical membranes. Multiple-indicator dilution experiments in presence of increasing cholyltaurine concentrations suggested an interaction of SMS 201–995 with sinusoidal bile salt transport. In isolated hepatocytes, uptake of SMS 201–995 was saturable and showed mutual inhibition with cholyltaurine. The results indicate that SMS 201–995 transport is different from receptor mediated endocytosis as known for peptide hormones and elimination pathways of SDZ CO-611 other than biliary excretion. (Hepatology 1994;20:191–200.)
P14.41 Temporal muscle thickness is an independent prognostic marker in patients with progressive glioblastoma: translational imaging analysis of the EORTC-26101 trial
Authors: J Furtner, E Genbrugge, T Gorlia, M Bendszus, M Nowosielski, V Golfinopoulos, M Weller, M J van den Bent, W Wick, M Preusser
Journal: Neuro-Oncology (2019)

Abstract BACKGROUND Temporal muscle thickness (TMT) was described as surrogate marker of skeletal muscle mass and prognostic parameter in brain metastasis patients. This study aimed to evaluate the prognostic relevance of TMT in patients with progressive glioblastoma. MATERIAL AND METHODS TMT was analyzed on the baseline cranial magnetic resonance (MR) images of 596 patients with progression of glioblastoma after radio-chemotherapy enrolled in the EORTC 26101 trial. An optimal TMT cutoff for overall survival (OS) and progression free survival (PFS) was defined in the training cohort (n=260 patients enrolled in phase 2 part of EORTC 26101). Patients were grouped as “below” or “above” the TMT cutoff and associations with OS and PFS were tested using the Cox model. The findings were validated in a test cohort (n=308 patients enrolled in phase 3 part of EORTC 26101). RESULTS An optimal baseline TMT cutoff of 7.2 mm was obtained in the training cohort for both OS and PFS (AUC=0.64). Univariate analyses estimated a hazard ratio (HR) of 0.54 (95% CI:0.42, 0.70, p&lt;0.0001) for OS and a HR of 0.49 (95% CI: 0.38, 0.64, p&lt;0.0001) for PFS for the comparison of training cohort patients above versus below the TMT cutoff. This was confirmed in multivariate testing for OS (HR of 0.54, 95% CI: 0.41, 0.70, p&lt;0.0001) and PFS (HR of 0.47, 95% CI: 0.36, 0.61, p&lt;0.0001) adjusted for the important risk factors with relevance in the trial for OS (Steroid use at baseline, HR of 1.58, 95% CI: 1.19, 2.11, p = 0.002; MGMT Status, HR of 0.51, 95% CI: 0.36, 0.72, p&lt;0.001; maximum diameter ≥ 40mm, HR of 2.49, 95% CI: 1.41, 4.41, p = 0.002; central hemisphere involvement, HR of 1.97, 95% CI: 1.37, 2.84, p&lt;0.001) and PFS (Neurological deficit, HR of 1.44, 95% CI:1.09, 1,92, p = 0.011; Steroid use at baseline, HR of 1.42, 95% CI: 1.08, 1.86, p = 0.011; MGMT status, HR of 0.61, 95% CI: 0.43, 0.87, p = 0.007; Number of target lesion &gt;1, HR of 2.47, 95% CI: 1.38, 4,41, p = 0.002). Similar results were obtained in the validation cohort. CONCLUSION TMT is an independent prognostic parameter in patients with progressive glioblastoma. This parameter is easily assessable on routine MR images and may help to better define frail patient populations and thus facilitate patient management by supporting patient stratification for therapeutic interventions or clinical trials.
The use of serum digoxin levels in clinical practice
Authors: R. H. Goldman
Journal: JAMA (1974)

THE need for an accurate and simple method of monitoring digitalis dosage is clearly evident from recent studies showing that 30% of patients admitted to a medical service had evidence of toxic effects from digitalis, while 11% of patients were "under-digitalized." Studies in experimental animals indicate that 60% of a lethal dose has been given when cardiac arrhythmias first appear, ie, at the point of maximal therapeutic effect. In addition, with the exception of the patient with atrial fibrillation in whom the ventricular rate usually can be used as a guide to further digitalis therapy, heretofore there has been no accurate, safe, and reliable clinical means to determine optimal digitalis therapy. To complicate matters further, there is no specific cardiac arrhythmia due to digitalis that cannot also be due to a patient's underlying heart disease. Hence, the clinician is often presented with the therapeutic choice of either increasing his patient's
Clinical guidelines for lumbar radiographs for patients with low back pain
Authors: B. Gutierrez
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Dr Suarez-Almazor and colleagues<sup>1</sup>note the potential for the Agency for Health Care Policy and Research (AHCPR) guideline recommendations for the diagnosis of low back pain to increase the use of lumbar radiographs for patients with "red flags" for fracture, tumors, or infections and suggest that a more restricted and cost-efficient set of guidelines should be proposed. As a large health insurance company with 6 million subscribers, we have chosen to use the AHCPR guideline recommendations to reduce the use of lumbar rediographs and other diagnostic imaging studies (magnetic resonance imaging and computed tomographic scans) of the lumbar region for the evaluation and management of patients with acute low back pain who do not exhibit red flags. We use the guidelines to educate our health care professionals about appropriate and cost-effective medical treatment. As with any recommendations, we do not expect strict adherence to the guideline
Abstract 2555: Modulation of protein interaction states in the cell cycle and during cancer drug action
Authors: Pär Nordlund
Journal: Cancer Research (2019)

Abstract The cellular thermal shift assay (CETSA) is a biophysical technique allowing direct studies of ligand binding to proteins in cells and tissues. The proteome-wide implementation of CETSA with mass spectrometry detection (MS-CETSA) is an efficient method to discover targets for orphan clinical drugs and hits from phenotypic screens, as well as to identify off-targets, explain poly-pharmacology and toxicity. Recently implemented highly sensitive multidimensional MS-CETSA techniques can now also access binding of physiological ligands to proteins, such as metabolites, nucleic acids and other proteins. MS-CETSA can thereby provide comprehensive information on modulations of protein interaction states in cellular processes, including downstream effects of drugs and transitions between different physiological cell states (Dai, Cell 2018, Tan, Science 2018). Such horizontal information on ligand modulation in cells is largely orthogonal to vertical information on the levels of different proteins, and therefore opens novel opportunities to understand operational aspects of cellular proteomes in more detail. We will discuss recent application of MS-CETSA to understand the cell cycle as well as cancer drug action and resistance. References: - Modulation of Protein-Interaction States through the Cell Cycle. Dai L, Zhao T, Bisteau X, Sun W, Prabhu N, Lim YT, Sobota RM, Kaldis P, Nordlund P. Cell. 2018 173(6):1481-1494. - Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells. Tan CSH, Go KD, Bisteau X, Dai L, Yong CH, Prabhu N, Ozturk MB, Lim YT, Sreekumar L, Lengqvist J, Tergaonkar V, Kaldis P, Sobota RM, Nordlund P. Science. 2018 359(6380):1170-1177. Citation Format: Pär Nordlund. Modulation of protein interaction states in the cell cycle and during cancer drug action [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2555.
Chinese Medicine
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vorlesungen über das Zentralnervensystem der Wirbeltiere.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fortification of nonfat milk solids with vitamins A and D
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health Messages
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epiphrenic diverticulum
Authors: G. Weitzman, C. Maltz
Journal: Endoscopy (2006)

A 73-year-old man with end-stage renal disease, who was hemodialysis-dependent, was referred for investigation because he complained of feeling too quickly sated and because he had lost weight. An esophagoscopy revealed a blind pouch in the distal esophagus, which was filled with retained food and secretions. This was occluding the distal esophagus. There seemed to be areas of necrotic mucosa in the pouch. After clearing of the retained material the gastroesophageal junction was identified and the stomach and duodenum were entered. Because of the patient’s malnourished state, a feeding tube was passed into the stomach under direct vision (Figure [1]).
Clinical implications of renin in the hypertensive patient
Authors: H. R. Brunner
Journal: JAMA (1975)

IN THE management of a hypertensive patient, the physician is faced with the primary question of what the most effective way to lower the blood pressure is, since blood pressure reduction has been shown to be the key to prevention of the major cardiovascular complications of hypertension.<sup>1,2</sup>More specifically, one must decide whether the hypertensive disorder is potentially curable by surgical intervention, or if not, what minimal antihypertensive drug regimen may succeed in normalizing the blood pressure. The aim of this discussion is to outline briefly how the measurement of plasma renin levels, or quantitation of the renin-angiotensin pressor effect, can be of value in the treatment of essential hypertension and in the diagnosis of surgically curable hypertension. Before reviewing the role of the renin-angiotensin system in clinical hypertension, it is necessary to understand the close physiologic link that exists between this hormonal system and body sodium and water
Premature Mortality by Income Level—Multnomah County, Oregon, 1976-1984
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rethinking Somatization
Authors: Jaywant J.P. Patil
Journal: Annals of Internal Medicine (1997)

Letters15 December 1997Rethinking SomatizationJaywant J.P. Patil, MD, BS, FRCP(C)Jaywant J.P. Patil, MD, BS, FRCP(C)Halifax, Nova Scotia B3H 4KY, CanadaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-12-199712150-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The article on rethinking somatization was interesting and thought-provoking [1]. It was of great interest to me because I deal on a daily basis with patients who have soft tissue musculoskeletal problems that do not respond to conventional medical treatment. McWhinney and colleagues have been critical of DSM-IV and the categories of classification that come under the heading “somatiform disorder.” I find the classification of conditions under this heading very useful in my daily practice. The type of patients I deal with have conditions that fall under the category of “chronic pain disorder,” which in turn falls ...References1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Assoc; 1995. Google Scholar2. Patil JJ. Fibromyalgia, myofascial pain syndrome, chronic pain syndrome, and somatization disorder: is there a connection? Dalhousie Medical Journal. 1996; 24:40-4. Google Scholar Author, Article, and Disclosure InformationAuthors: Jaywant J.P. Patil, MD, BS, FRCP(C)Affiliations: Halifax, Nova Scotia B3H 4KY, Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1997Volume 127, Issue 12Page: 1132-1133KeywordsBehaviorDiagnostic and Statistical Manual of Mental Disorders fourth editionFallsHealth careMedical conditionsSoft tissuesSurgery ePublished: 15 August 2000 Issue Published: 15 December 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Atrio-biventricular pacing improves cardiopulmonary exercise in heart failure patients with stable sinus ryhthm Chetan Varma, Sr., Sam Firoosi, Sr., Sanjay Sharma, Sr., William J. McKenna, Sr., Claude Daubert, Sr., Dpt de Cardiologie CHU, Rennes, France
Journal: Journal of the American College of Cardiology (2001)
Stress
Authors: N. Cousins
Journal: JAMA (1979)

The concept of stress is not confined, as is sometimes supposed, to a description of what happens when the human organism is pushed beyond its coping capacity. The stress concept is integrally connected to the concepts of homeostasis and restoration. Homeostasis, as conceived by Walter B. Cannon, MD, is a condition marked by an equilibrium of forces inside the human body. The concept is basically concerned with the workings of the endocrine system, but it also is intended to define a state in which all the elements and factors involved in the proper functioning of the human body are in vital balance with one another. Restoration is the natural drive of the human body to reassert its physical and mental integrity against assault or breakdown. It is natural for the body to right itself, to resist illness, and to overcome disease when it takes hold. The human body has had
Endocrine Diagnosis
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal