tbuckley/cabot-search huggingface dataset:
Quantitatively Determined Survivin Expression Levels Are of Prognostic Value in Human Gliomas
Authors: A. Chakravarti
Journal: Journal of Clinical Oncology (2002)

PURPOSE: Survivin is a novel antiapoptotic gene that has been recently cloned and characterized. Its expression has been found to be of prognostic significance in several tumor types. This is the first study on the prognostic significance of survivin expression in human gliomas. MATERIALS AND METHODS: We used quantitative Western blot analysis with densitometry to determine survivin protein expression levels in 92 glioma cases for which frozen tissue was available for analysis. Survivin positivity and expression levels were correlated with histopathologic features of the tumors, apoptosis (as measured by cleaved, or activated, caspase 3 levels), and clinical outcome. RESULTS: Survivin expression has clear prognostic value in human gliomas. Patients with detectable survivin expression had significantly shorter overall survival times (P < .0001) compared with those without detectable expression when all glioma patients were considered. Although glioblastoma multiforme (GBM) patients had significantly higher rates of survivin positivity and higher levels of survivin expression (P < .0001) than their non-GBM counterparts, the prognostic value of survivin expression seemed to be independent of histology alone. Survivin-positive GBM patients had significantly shorter overall survival times compared with survivin-negative GBM patients (P < .0001). Likewise, survivin-positive non-GBM patients had shorter survival times compared with survivin-negative non-GBM patients (P = .029). Furthermore, increasing levels of survivin expression significantly correlated with reduced survival times when all glioma patients were considered, and markedly so for GBM patients (P < .0001). Increasing survivin levels significantly correlated with reduced expression of cleaved caspase 3, indicating its association with antiapoptotic activity. CONCLUSION: Survivin positivity and protein expression levels, as determined quantitatively, are of significant prognostic value in human gliomas and seem to be associated with reduced apoptotic capacity of these tumors.
CORONER VERSUS MEDICAL EXAMINER
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Retraction Notice: Suicide Rates by Occupational Group — 17 States, 2012
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

On July 1, 2016, MMWR published "Suicide Rates by Occupational Group - 17 States, 2012" (1). On June 14, 2018, the authors informed MMWR about their concerns regarding the validity of some of the findings in the report, and on June 29, 2018, MMWR published "Notice to Readers: Ongoing Analysis of Suicide Rates Data by Occupational Group from Results Reported in MMWR" (2). The analysis is complete, and because the corrections change the conclusions, the original report is retracted.
Canadian government is attacked for plan to legalise marijuana
Journal: BMJ (2003)

relatively small.Also, patients in the virtual outreach group reported significantly shorter time off work than patients in the standard outpatient group.The trial results provide good evidence that virtual outreach consultations are less time consuming and cheaper for patients and are likely to have a positive impact on productivity.Considering total costs, little justification on economic grounds seems to exist for the adoption of virtual outreach.However, all the benefits may not have been recouped within the six month follow up period, and we did not estimate values of improved patient satisfaction.We may therefore have underestimated the beneficial consequences of virtual outreach.Furthermore, previous subanalysis showed that certain specialties may be more appropriate for virtual outreach than others, 5 and improved selection of patients may also improve the relative cost effectiveness of virtual outreach.We acknowledge the invaluable contribution made by all the participating clinicians and nursing, administrative, and management staff in both the London and Shrewsbury arms of the trial (see bmj.com).Ann Bowling and John Wynn Jones provided valuable input to the design of the study, and we thank Will Coppola for help with extraction of prescription data.The project office in London
The Alcohol-Uric Acid Question
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Entzündung, Trombose, Embolie und Metastase im Lichte neuerer Forschung.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HIV Transmission Among Black Women—North Carolina, 2004
Journal: JAMA (2005)

In 2003, women constituted 28% of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) cases in the United States; approximately 69% of those cases were among non-Hispanic black women. Heterosexual transmission is now the most commonly reported mode of HIV transmission among women. In North Carolina, black women make up a growing proportion of newly reported HIV infections and, in 2003, the HIV-infection rate for black women in North Carolina was 14 times higher than that for white women. Despite this disparity, few epidemiologic studies have examined HIV transmission among black women in the United States, particularly those residing in southern states. In August 2004, the North Carolina Department of Health (NCDOH) invited CDC to assist in an epidemiologic investigation of HIV transmission among black women in North Carolina. This report summarizes the results of that investigation, which indicated that the majority of HIV-positive and HIV-negative sexually active black women in North Carolina reported HIV sexual risk behaviors. These findings underscore the need for enhanced HIV-prevention strategies in this population.
Continuing Education Courses for Physicians
Authors: C. H. William Ruhe
Journal: JAMA (1963)

This is the ninth annual listing of courses in continuing medical education in the United States and covers the period from Sept 1, 1963, through Aug 31, 1964. <h3>Purpose of the List</h3> The list is provided as a service to physicians and to organizations which are active or interested in the field. It provides the individual physician with a single, convenient source of information about the number and nature of courses available throughout the country and enables him to plan his personal program of continuing education thoughtfully and systematically for the entire year. For organizations active in the field, it provides a ready reference to the ongoing activities of other groups. For institutions considering the establishment or expansion of programs, it furnishes information showing the areas of medicine and the geographic regions which are well covered and
Neurology
Authors: R. J. Joynt
Journal: JAMA (1992)

Interest in neurology and neuroscience continues to mount as new research unveils more of the basic changes underlying neurological disorders. Advances in prevention, diagnosis, and treatment of neurological disease will depend on elucidation of their pathology on a genetic, molecular, and cellular level. An example of treatment arising from fundamental knowledge about disease mechanisms is enzyme replacement therapy in Gaucher's disease. Gaucher's disease is caused by a deficiency of the enzyme glucocerebrosidase, with consequent accumulation of glucocerebrosides in macrophages. It results in a gradual enlargement of visceral organs, replacement of bone marrow, and, in some persons, progressive neurological deterioration. The progression of the disease was beneficially altered by the infusion of macrophage-targeted glucocerebrosidase in 12 patients.<sup>1</sup>Organ enlargement was reversed, anemia was corrected, and energy was improved. Similar approaches may be beneficial in other enzyme-deficiency disorders. The issue of treatment for carotid stenosis has been controversial. A large, multicenter
GANGRENOUS EXTREMITIES AND INTRA-ARTERIAL INJECTIONS
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Era Key to the USP XI &amp; NF VI
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serology in Syphilis Control: Principles of Sensitivity and Specificity. With an Appendix for Health Officers and Industrial Physicians
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 48: Cellular dynamics and heterogeneity of active Kras induced-gastric pre-neoplasia in mouse
Authors: Eunyoung Choi, Paige N. Vega, Jimin Min, Amy C. Engevik, janice A. Williams, Qing Yang, Loraine M. Patterson, Alan J. Simmons, Ken S. Lau, Scott T. Magness, James R. Goldenring
Journal: Cancer Research (2019)

Abstract Cellular heterogeneity in cancer development is considered as a source of cancer cell generation and drug resistance. However, cellular heterogeneity has not been fully eluciated during metaplasia progression to gastric pre-neoplasia and neoplasia in gastric carcinogenesis. Recent investigations have suggested that Ras activation, rather than Ras mutation, may promote the gastric carcinogenesis. We have recently established several in vitro metaplastic/pre-neoplastic organoid lines; Meta3-metaplasia and Meta4-pre-neoplasia, derived from mouse stomachs induced active Kras expression in chief cells and investigated cellular heterogeneity and plasticity that may lead to the progression of metaplasia to gastric neoplasia. While both Meta3 and Meta4 initially formed spherical or spheroidal structures and generated complicated budding or cyst-like structures between 2 and 4 weeks, Meta4 cells displayed more disorganized structures and aggressive behaviors than Meta3. We also examined altered cellular behaviors, structural changes and survival of Meta4 organoids after MEK inhibition which is a downstream mediator of Kras signaling pathway. The Meta4 treated with Selumetinib for 3 days died or did not show an increase in size at various concentrations. However, some Meta4 organoids showed an ability to survive and retained a spheroidal structure despite the Selumetinib treatment. Single cell-RNA sequencing (scRNA-seq) data analysis demonstrated distinct characteristics of Meta4 cells as pre-neoplastic cells and a signature of presence and heterogeneity of pre-neoplasia stem cell (PNSC) populations. The scRNA-seq data analysis also revealed that cellular behavior and dynamics of pre-neoplastic cells can be controlled by MEK inhibition, but the PNSC populations still maintain the niche for stem-like cells in gastric pre-neoplasia. The isolated two PNSC populations showed functional differences and the stemness of the PNSCs in pre-neoplastic stage through high-throughput functional analysis. Therefore, our study concludes that putative gastric cancer stem cells in gastric pre-neoplasia might be the source for maintenance of heterogeneity and contribute to the progression of gastric pre-neoplasia to cancer. Citation Format: Eunyoung Choi, Paige N. Vega, Jimin Min, Amy C. Engevik, janice A. Williams, Qing Yang, Loraine M. Patterson, Alan J. Simmons, Ken S. Lau, Scott T. Magness, James R. Goldenring. Cellular dynamics and heterogeneity of active Kras induced-gastric pre-neoplasia in mouse [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 48.
Tabes Dorsalis, The Lumleian Lectures, Delivered before the Royal College of Physicians, London, March, 1906.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstracts
Journal: Annals of the Rheumatic Diseases (1969)

It is known that streptolysin S (SLS) produces a "non- specific" stimulation of lymphocytes from normal donors, 40 to 90 per cent. of the cells undergoing blast transforma- tion, whereas lymphocytes from patients with untreated acute rheumatic fever (ARF) fail to respond in this way.However, lymphocytes from patients with ARF who have received penicillin and from patients with other diseases show the normal 40 to 90 per cent.response to stimulation.The authors of this paper from the Hebrew University-Hadassah Medical School and Bikur Cholim Hospital, Jerusalem, have attempted to use these differences as the basis of a diagnostic test.Lymphocytes wereseparated from5 to 15 ml.heparinized blood and cultured in either calf serum or autologous plasma, and the effects of stimulation with SLS were compared with those of stimulation with phytohaemagglutinin and staphylococcal filtrate. [For details the original should be consulted.]In calf serum the percentage transformation in response to SLS was less than seven for all of ten children suffering their first attack of ARF.Six out of thirteen patients suffering a second attack of ARF, one out of four suffering a third attack, and all of five with inactive rheumatic fever had percentage transformations above seven, as did seven out of eight normal (adult) controls and eighteen out of twenty children with a variety of non- rheumatic disorders.On the other hand, all the subjects reacted similarly to phytohaemagglutinin and staphylococcal filtrate.The degree of transformation provoked by SLS in a given case often changed (in either direction) if autologous plasma was used instead of calf serum in the culture medium.The authors discuss their findings and conclude that the value of the procedure as a diagnostic test for ARF "is limited as some patients with acute rheumatic fever react normally while some patients with other diseases show a diminished response".
Quantitative Studies on the in Vitro Metabolic Activation of Dimethylnitrosamine by Rat Liver Postmitochondrial Supernatant
Authors: David J. Doolittle, Jay I. Goodman
Journal: Environmental Health Perspectives (1984)

The metabolic activation of dimethylnitrosamine (DMN) to mutagenic and/or cytotoxic intermediates in vitro has been characterized and the relationship between DMN demethylase and ethoxyresorufin-O-deethylase (EROD) or ethylmorphine-N-demethylase (EMND) has been evaluated. A mammalian assay system which uses the postmitochondrial supernatant (S-15 fraction) prepared from a rat liver homogenate as an enzyme source and V79 Chinese hamster cells as targets for chemically induced damage was used. The enzyme pattern of the S-15 fraction was altered by pretreatment of experimental animals in vivo and/or by the use of enzyme inhibitors in vitro. The results of these studies indicate that the concentration of S-15 fraction in the reaction mixture can markedly influence the degree of DMN-induced cytotoxicity when it is metabolized in vitro and that the degree of DMN-induced cytotoxicity and mutagenicity are linearly related. The degree of cytotoxicity and mutagenicity induced in V79 cells by DMN does not correlate with EROD activity (a measure of 3-methylcholanthrene-inducible mixed-function oxidases) nor with EMND activity (a measure of phenobarbital-inducible mixed function oxidases) in the S-15 fraction.