tbuckley/cabot-search huggingface dataset:
Corrections
Authors: J Scott, Norman Capener
Journal: BMJ (1967)

Education in ManagementWise management of existing hospital resources is the keynote of the annual report of King Edward's Hospital Fund for London.The Fund organizes courses in manage- ment for consultant medical staff and senior registrars.The main theme is the efficient use of resources (beds, services, money, and manpower) and ways and means of measur- ing efficiency.In September next year the four staff colleges will merge to form the King's Fund College of Hospital Manage- ment.Grants in 1966
APPOINTMENT OF ASSISTANT SURGEONS IN THE ARMY.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gastroenterologic endoscopy
Authors: P. Swain
Journal: Gut (1989)

Fibre and enteral nutrition SIR,-We read with great interest Dr Silk's review,' but we were surprised at the omission of any detail on the effects of enteral nutrition on cholesterol metabolism.In our own experimental studies,' rats fed for 10 weeks with Vivonex develop severe fatty infiltration of the liver, similar to Kwashiorkor, with initial deposition of fat in the periportal regions with progressive involvement around the central vein with significant quantitative increases in total liver lipid and cholesterol.No such changes were detectable in the livers of animals fed for 10 weeks with Vivonex which was supplemented with 5% wheat bran.The accumulation of lipids and cholesterol in the livers of rats fed Vivonex has been reported by others.' We concluded that dietary bran thus appears to play a role in maintaining normal lipid metabolism and suggest that caution be exercised in those patients on longterm enteral feeding with careful monitoring of blood lipids.
Retraction Note to: MicroRNA-330-3p promotes cell invasion and metastasis in non-small cell lung cancer through GRIA3 by activating MAPK/ERK signaling pathway
Authors: Chun-Hua Wei, Gang Wu, Qian Cai, Xi-Can Gao, Fan Tong, Rui Zhou, Rui-Guang Zhang, Ji-Hua Dong, Yu Hu, Xiao- Rong Dong
Journal: Journal of Hematology & Oncology (2020)

An amendment to this paper has been published and can be accessed via the original article.
Authors' Address
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cutaneous Medicine.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pharmacologic basis for use of propoxyphene
Authors: G. F. Kiplinger
Journal: JAMA (1971)

From a review of pharmacologic data, it is shown that propoxyphene hydrochloride is essentially a centrally acting analgesic, differing in mode of action from peripherally acting aspirin (typifying the antipyretic and anti-inflammatory group). It is postulated that, if two drugs produce a similar degree of analgesia by different mechanisms, the "additive" effect of the combination will produce greater analgesia than doubling the dose of either. This concept is supported by the wide clinical experience with, and acceptance of, analgesic combinations of a codeine or propoxyphene-type compound and an aspirin type of drug. The low incidence of side effects and the minimal abuse potential are also factors in clinical decisions relating to analgesia with propoxyphene.
The physician and sickness absence
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Firearm and nonfirearm homicide among persons 15 through 19 years of age. Differences by level of urbanization, United States, 1979 through 1989
Authors: L. A. Fingerhut
Journal: JAMA (1992)

<h3>Objective.</h3> —To examine trends (1979 through 1989) and current status in firearm and nonfirearm homicide rates by level of urbanization among persons 15 through 19 years of age. <h3>Design.</h3> —The Compressed Mortality File, a county-level mortality and population database maintained by the National Center for Health Statistics, Centers for Disease Control, Hyattsville, Md, and the 1980 Human Resource Profile County Codes are used to analyze age-, sex-, and race-specific firearm and nonfirearm homicide rates by urbanization level. <h3>Setting.</h3> —United States, 1979 through 1989. <h3>Subjects.</h3> —Black and white males and females 15 through 19 years of age whose underlying cause of death was either firearm homicide (E965.0 through E965.4 or E970) or nonfirearm homicide (E960 through E964, E965.5 through E969, or E971 through E978) in the<i>ICD-9 (International Statistical Classification of Diseases, Injuries, and Causes of Death, Ninth Revision).</i> <h3>Main Outcome Measures.</h3> —Urbanization level-specific firearm and nonfirearm homicide rates. <h3>Results.</h3> —The 1989 firearm homicide rate in metropolitan counties was nearly five times the rate in nonmetropolitan counties (13.7 vs 2.9 deaths per 100000 population). Firearm homicide rates were highest in core metropolitan counties, 27.7 per 100000 population; rates were higher for black males than for any other race-sex group in each of five county urbanization strata for 1979 through 1989. Nonfirearm homicide rates are considerably lower, with smaller urban differentials; the rate in metropolitan counties was 1.4 times the rate in nonmetropolitan counties (2.6 vs 1.8 per 100 000 population). From 1979 through 1984, firearm homicide rates declined in each of the county strata. From 1984 through 1987, firearm homicide rates increased, and from 1987 through 1989 they increased rapidly, from 23% to 35% per year in the four metropolitan strata. From 1979 through 1989, nonfirearm homicide rates declined or remained stable. <h3>Conclusions.</h3> —Large urbanization differentials in firearm homicide and smaller differentials in nonfirearm homicide are identified. Firearm homicide rates are highest and increasing the fastest among black teenage males in the core, fringe, and medium metropolitan strata. (<i>JAMA</i>. 1992;267:3048-3053)
International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in Latin America
Authors: Marina Wainstein, Aminu K. Bello, Vivekanand Jha, David C.H. Harris, Adeera Levin, Maria C. Gonzalez-Bedat, Guillermo J. Rosa-Diez, Alejandro Ferreiro Fuentes, Laura Sola, Roberto Pecoits-Filho, Rolando Claure-Del Granado, Magdalena Madero, Mohamed A. Osman, Syed Saad, Deenaz Zaidi, Meaghan Lunney, Feng Ye, Ivor J. Katz, Maryam Khan, Sally Shrapnel, Marcello Tonelli, Ikechi G. Okpechi, David W. Johnson
Journal: Kidney International Supplements (2021)
Glucocorticoid Use and Risks of Ocular Hypertension and Glaucoma
Authors: André Cartier
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Dr Garbe and colleagues<sup>1</sup>incriminate highdose inhaled corticosteroids in the increased risk of ocular hypertension and open-angle glaucoma. However, several substantial criticisms can be made regarding this study. The distinction between ocular hypertension and glaucoma, the case definition, is not of minor importance as claimed by the authors. In the report by Garbe et al, 51% of cases did not receive any treatment for glaucoma, which is unusual. One would expect that these at-risk subjects would be followed up by their ophthalmologists within 4 to 6 months; this could be verified by the authors. In this older population, COPD from cigarette smoking is probably more frequent than asthma per se; both conditions are often treated with inhaled corticosteroids, although the indication for steroids in COPD is controversial. Cigarette smoking is a known risk factor for development of cataract<sup>2</sup>and cardiovascular diseases.<sup>3</sup>On one hand, topical glucocorticoids usually
Effects of Nutritive Factors on Metabolic Processes Involving Bioactivation and Detoxication of Chemicals
Authors: F. Guengerich
Journal: Annual Review of Nutrition (1984)

The objective of this review is to provide an overview of intermittent fasting regimens, summarize the evidence on the health benefits of intermittent fasting, and discuss physiological mechanisms by which intermittent fasting might lead to improved ...Read More
Hereditary Deafness in Man
Authors: Bruce W. Konigsmark
Journal: New England Journal of Medicine (1969)

Hereditary Deafness Associated with Eye DiseaseThere are nine hereditary diseases in which the auditory and visual systems are both affected. The eye lesions involve the lens, bulb, retina or optic nerve. Other parts of the nervous system are sometimes involved.Dominant Saddle Nose, Myopia, Cataract and Hearing LossSeven members in four generations of a family studied by Marshall53 in 1958 had a syndrome including saddle-nose defect, congenital and juvenile cataracts, myopia and hearing loss. The prominent facial deformity, with sunken nose bridge, made affected persons easy to identify. Myopia was also evident from birth. Affected family members reported . . .
Error in Byline
Authors: Michael Yokell, Scb Delgado, Nickolas Zaller, N Wang, Samuel Mcgowan, Traci Craig Green
Journal: JAMA Internal Medicine (2014)

The economic and health care utilization burden that overdose exacts on US EDs and the health care system in general was substantial in our national sample.These findings suggest that the costs associated with opioid overdose are significant and that strategies to reduce morbidity and mortality resulting from overdose are urgently needed, including enhanced access to substance abuse treatment.This study found 135 971 visits to US EDs for opioid overdose in 2010 alone.This number represents only a portion of all opioid overdoses because many individuals never present to an ED or die without activation of the emergency medical services system.
Two-Generation Saccharin Bioassays
Authors: D. L. Arnold
Journal: Environmental Health Perspectives (1983)

The controversy regarding the safety of saccharin for human consumption started shortly after its discovery over 100 years ago and has yet to subside appreciably. The consumption of saccharin, particularly in North America, began to escalate when the U.S. Food and Drug Administration set new standards of identity which allowed foods containing artificial sweeteners to be promoted as "nonnutritive" or "noncaloric" sweeteners for use by the general public. In 1969, when cyclamates were banned, at least 10 single-generation feeding studies were undertaken with saccharin to more accurately assess the potential toxicological consequences resulting from the anticipated increase in its consumption. None of these studies resulted in any overt regulatory action. Subsequently, the introduction of the two-generation chronic toxicity/carcinogenicity bioassay added a new tool to the toxicologist's arsenal. Three two-generation studies using saccharin have since been conducted. The results from these studies clearly show that when rats were exposed to diets containing 5 or 7.5% sodium saccharin from the time of conception to death, an increased frequency of urinary bladder cancers was found, predominantly in the males. While some study results suggested that impurities in commercial saccharin or the presence of urinary tract calculi may have been responsible for the observed bladder tumors, it now appears that these possibilities are highly unlikely. The mechanism by which saccharin elicited the bladder tumors using the two-generation experiment has not been ascertained.
ELECTION OF OFFICERS.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Induction of human hepatic bile acid binder (HBAB)/dihydrodiol dehydrogenase (HDDH) by oxidant stress is mediated by antioxidant response element (ARE) . Division of Digestive and Liver Diseases, USC School of Medicine, Los Angeles, CA 90033
Journal: Hepatology (1995)

The functionality of primary rat hepatocytes was assessed in an Integrated Dynamic Cell Cultures in Microsystem (IDCCM) device. We characterized the hepatocytes over 96 h of culture and evaluated the impact of dynamic cell culture on their viability, inducibility, and metabolic activity. Reverse Transcription quantitative Polymerase Chain Reaction (RTqPCR) was performed on selected genes: liver transcription factors (HNF4α and CEBP), nuclear receptors sensitive to xenobiotics (AhR, PXR, CAR, and FXR), cytochromes P450 (CYPs) (1A2, 3A2, 3A23/3A1, 7A1, 2B1, 2C6, 2C, 2D1, 2D2, and 2E1), phase II metabolism enzymes (GSTA2, SULT1A1, and UGT1A6), ABC transporters (ABCB1b and ABCC2), and oxidative stress related enzymes (HMOX1 and NQO1). Microperfused-cultured hepatocytes remained viable and differentiated with in vivo-like phenotype and genotype. In contrast with postadhesion gene levels, the first 48 h of perfusion enhanced the expression of xenosensors and their target CYPs. Furthermore, CYP3A1, CYP2B1, GSTA2, SULT1A1, UGT1A1, ABCB1b, and ABCC2 were upregulated in IDCCM and reached above postextraction levels all along the duration of culture. Metabolic activities were also confirmed with the detection of metabolism rate and induced mRNAs after exposure to several inducers: 3-methylcholanthrene, caffeine, phenacetin, paracetamol,, and midazolam. Finally, this metabolic characterization confirms that IDCCM is able to maintain rat hepatocytes functions to investigate drug metabolism.
The Diagnosis and Treatment of Esophageal Cancer
Authors: Eugene Cliff
Journal: CA A Cancer Journal for Clinicians (1970)

Esophageal cancer has a bad reputation.Do you have anything optimistic to say about it?DR.CLIFFTON: I can only make a plea for early diagnosis and the best use of surgical and radiation techniques now available to bring about some improvement in palliation and the cure rates.Even under the best circumstances the cure rate is by no means impressive.Palliation is still our prime aim in the majority of patients.
一种测量患者化脓性汗腺炎程度的新方法
Authors: J.S. Kirby, M. Butt, T. King
Journal: British Journal of Dermatology (2020)

化脓性汗腺炎 (HS) 是一种引起大疖、脓疱形成的皮肤病。它通常会影响人体的皮肤褶皱处(例如腋窝和腹股沟),并可能导致严重的炎症、疼痛、痒、疤痕和外形毁损。 在美国和欧洲,约 0.1%‐1% 的人患有 HS。HS 多见于女性。当研究测量皮肤上的 HS 时,他们通常需要临床医生(例如医生)来计数每种类型 HS 病变(受影响的皮肤区域)的数量。这可能很困难,因此,一名临床医生可能计算出与另一名临床医生不同的数字。如果临床医生不能达成一致,则这不是准确的测量工具。 本研究由美国的研究人员完成,旨在发现临床医生使用不同方法测量 HS 的能力。作者采访了治疗 HS 的临床医生,以了解他们观察到的皮肤变化,从而决定 HS 是好转还是恶化。由此,研究人员根据 HS 的面积大小以及发红、肿胀和破损皮肤的面积大小,开发了一种新的 HS 测量方法。 接下来,作者让 10 名临床医生检查了 23 例 HS 患者,他们完成了新测量和现有测量。与现有的 HS 测量方法相比,新测量在临床医生中具有更高的一致性。此外,临床医生在测量具有 HS 的同一个人时更可能与自己保持一致。 本研究表明,HS 病变计数较为困难,不同的方法可能有助于改善 HS 测量。 本摘要涉及研究:汗腺炎严重程度和面积评分 (SASH):一种新的化脓性汗腺炎结局测量指标
Ball-value obstruction of terminal ileum of long duration by a rare phytobezoar
Authors: R. Weinerman
Journal: JAMA (1967)

AN UNUSUAL CASE of ball-valve obstruction of the small bowel due to a phytobezoar is being reported, because of the unusually long duration (44 years) it was present. There were associated proximal and distal strictures of the ileum, ulceration, and anemia due to blood loss. <h3>Report of a Case</h3> A 53-year-old mechanic was admitted to the Misericordia General Hospital, Jan 14, 1966, because of black stools, pain in the right lower and left upper quadrants of the abdomen, and anemia. The patient reported May 23, 1956, to his doctor. He complained of abdominal pain, irregular bowel habits, and blood staining on toilet tissue for six months. The pain was crampy, and located in the right lower quadrant. It was associated with bloating and belching and came on about once a week in the midafternoon. Results from a physical examination in 1956 were normal except for small hemorrhoids on anoscopic examination.
PWE-014 Polo-like kinase 1 expression predicts aneuploidy in the Barrett's metaplasia-dysplasia-carcinoma sequence
Authors: M A Butt, R J Haidry, D Oukrif, J M Dunn, A Gupta, M Bhatt, L Hrynkiewicz, A Waheed, C Owen, A Machhada, M Rodriguez-Justo, M R Banks, L B Lovat, M R Novelli
Journal: Gut (2012)

<h3>Introduction</h3> Finding an accurate and convenient biomarker for cancer progression in Barrett9s (BE) is of high clinical importance. DNA ploidy abnormalities (DNA-PA) are a reliable predictor of cancer risk in BE, but measurement is expensive and scarcely available. We have shown polo-like kinase-1 (PLK1) may act as a surrogate marker of DNA-PA in oesophageal adenocarcinoma (OA) resection specimens. This study aimed to examine the potential of PLK1 in predicting DNA-PA in the metaplasia-dysplasia-OA sequence. <h3>Methods</h3> 36 paraffin embedded oesophageal tissue specimens were selected from patients with non-dysplastic BE (NDBE, n=5), low grade dysplasia (LGD, n=5), high grade dysplasia (HGD, n=12), intramucosal cancer (IMC, n=5) and invasive OA (IOA, n=9). Sections were mounted and immunostained with 2 PLK-1 antibodies PLK1-M and PLK1-L using an automated system (BOND-MAX, Leica) for consistency. Results were reported by two independent expert pathologists blinded to patient status with the Allred scoring system, a composite of the percentage and intensity of staining. <h3>Results</h3> Aneuploidy was present in LGD (20%), HGD (75%), IMC (20%) and IOA (56%) samples. Using linear regression analysis, Pearson coefficient was calculated for the correlation between DNA-PA and mean Allred expression scores for each PLK1 antibody. PLK1-M had a higher degree of correlation (r<sup>2</sup>=0.26, p=0.001) then PLK1-L (r<sup>2</sup>=0.22, p=0.004). Inter-observer analysis with linear κ scores confirmed good correlation of PLK1-M (κ=0.72, 95% CI 0.60 to 0.83) and PLK1-L (κ=0.53, 95% CI 0.38 to 0.68), but a Bland–Altman plot found pathologist 2 had a trend to score PLK-L more highly. However, intra-observer analysis confirmed both PLK1-L scores correlated with ploidy status (r<sup>2</sup>=0.14, p=0.023 and r<sup>2</sup>=0.27, p=0.0016). Pathologists took 90.3 s/slide (mean) to review and score with the Allred method. Using a mean Allred cut off score of 3.5, the sensitivity and specificity for the detection of aneuploidy were 81.3% and 75% for PLK1-M, 93.8% and 45% for PLK1-L. <h3>Conclusion</h3> This pilot study demonstrated a significant correlation between Allred reporting of PLK1 staining and DNA-PA. PLK1-L appears more sensitive and PLK1-M more specific. PLK1 immunostaining is relatively inexpensive, less work intensive and is more available than current methods to predict DNA-PA. Scoring staining with Allred is rapid and reproducible. In future, PLK1 staining may provide the basis of a more durable biomarker panel to predict DNA ploidy. <h3>Competing interests</h3> None declared.