AB0757 TAKAYASU DISEASE: ABOUT 109 CASES
Authors: H. Khibri, F. Ibourk El Idrissi, A. Meghraoui, M. Obtel, C. Yasmina, N. Mouatassim, W. Ammouri, M. Maamar, H. Harmouche, M. Adnaoui, Z. Tazi Mezalek
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> TAKAYASU disease is an inflammatory vasculitis of the means and large caliber, which affects th aorta and its main branches, and which leads to the formation of arterial stenosis, thromboses and aneurysms. Touching preferably young women, it may be responsible for complications severe visceral events that may be life-threatening. <h3>Methods</h3> We conducted a 38-year, single-centric retrospective study (1984 and 2022) in patients followed for TAKAYASU vasculitis at the department of internal medicine and the department of vascular surgery of the Ibn Sina Hospital in Rabat. Statistical data were analyzed using SPSS 20. 0 software and KHI- DEUX analytical test. <h3>Results</h3> We collected 109 files. The sex ratio (F/M) was 7. 3 (96 women/ 13 men). 11. 92% of patients were male. The mean age was 34. 8 ±11. 9 (12 – 62 years). Patients who had juvenile takayasu diagnosed before 20 years of age were 11 (10%) and patients who had late-diagnosed takayasu to over 50 years of age were 14 (12. 88%). HTA was present in 44 (40. 7%) of patients at diagnosis, 11 (10. 1) of patients were taking oral contraceptives. Inflammatory syndrome was associated in 72 (66. 1%) with no statistically significant difference with a P=0. 6. Vascular symptomatology was present in 103 (95. 4%) of the cases o vascular murmur (66. 1%), pulse suppression (62. 4%), intermittent claudication (49. 5%) and ischemia (10. 1%). Extravascular symptoms were present in 47. 6% of the patients dominated by inflammatory arthralgia (18. 3%). Only one patient had asymptomatic TAKAYASU vasculitis discovered by chance during ultrasound examination for a thyroid nodule. Cardiac involvement occurred in 36 (33%) of patients and consisted mainly of valvulopathy (20. 2%) and cardiomyopathy (17. 4%). Central neurological involvement was present in 17 patients. (15. 6%) of patients with complicated HAI in 13 patients. Renal impairment was present in 35 patients (32. 11%). Ophthalmologic involvement in 26 (23. 9%) of patients was mainly represented by retinal vasculitis and optic nerve involvement. In addition, 10 patients had 24 pregnancies, 4 patients had preeclampsia, we recorded 9 abortions and half of our patients had full term pregnancies. The type of injury in our series was mainly stenosis and was found in 73 (67%) of cases. Occlusion was recovered in 21 (19. 3%) patients. Thrombosis was found in 26 (23. 9%) of patients and aneurysms in 19 (17. 4%) of patients. TAKAYASU vasculitis was Type I in 42 (38. 5%) patients, followed by Type V in 39 (35. 8%). Type IIa was present in 7 patients (6. 4%), type IIb in 4 patients (3. 7%), type III in 2 patients (1. 8%), and type IV in 14 patients (12. 8%). Most patients 104 (95. 4%) received corticosteroids and 77 (70. 6%) received immunosuppressive therapy including one on mycophenolate mofetil. 2 patients received anti-TNF therapy (adalimumab) and 1 patient received Tocilizumab. At the surgical level; 9 (8. 3%) of patients had angioplasty; A further 6 (8. 3%) underwent cardiac surgery (5 aortic valve replacement and closed-heart commissurotomy) and 15 (13. 8%) had vascular surgery. The outcome was favourable in the majority of patients. Late relapses &gt; 6 months were reported in 25 (23. 1%) patients. There was only one death from global heart failure. We analyzed several associations such as vascular and cardiac disease, vascular and neurological disease. None returned significant with P ranging from 0. 3 to 1. <h3>Conclusion</h3> The results of our study are consistent with the literature and confirm the predominance of women and the stenosing nature of this vasculitis. Early diagnosis and management of the disease significantly improves the progression profile of the disease. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.