tbuckley/cabot-search huggingface dataset:
Interstitial high dose rate (HDR) brachytherapy alone for early stage prostate cancer
Authors: P. Anderson, R. Mark, T. Neumann, G. Vallabhan, M. Nair, R. Akins
Journal: Journal of Clinical Oncology (2005)

4729 Background: Transrectal Ultrasound (TRUS) guided interstitial implant for prostate cancer using Low Dose Rate (LDR) and High Dose Rate (HDR) technique has been reported with results comparing favorably to surgery and External Beam Radiation Therapy (EBRT). Often, HDR and LDR interstitial implant is combined with EBRT. We report our results with HDR alone. Methods: Between 1997 and 2004, 137 patients with T1 and T2 prostate cancer underwent TRUS guided interstitial implant. No patient received XRT or Hormonal Blockade. Median Gleason Score was 7 (range: 4 to 10). Median PSA was 9.3 (2.7 to 39.8). Treatment volumes ranged from 42 cm3 to 196 cm3. Two HDR Implants were performed, spaced 4 weeks apart. The treatment volume received 2,250 cGy in 3 fractions prescribed to the 100% Isodose line, given over 24 hours. A 2nd implant was performed 4 weeks later, delivering a further 2,250 cGy in 3 fractions, bringing the final dose to the prostate to 4,500 cGy in 6 fractions. Urethral dose points (12–16) were followed, and limited to ≤ 105% of the prescription dose. Results: With a median follow-up of 48 months (range: 6 months to 92 months), PSA disease free survival was 91.9% (126/137). Acute urinary retention occurred in 3.6% (5/137) of the patients, requiring temporary insertion of an indwelling foley catheter. Deep venous thrombosis occurred within one month of HDR in 2.2% (3/137). Urethral stricture requiring dilatation has developed in 2.9% (4/137). Urinary stress incontinence has occurred in 1.5% (2/137). RTOG late bladder toxicities were: 0% Grade 4, 0% Grade 3, and 2.9% (4/137) Grade 2. RTOG late rectal toxicities were: 0.7% (1/137) Grade 4, 0% Grade 3, 1.5% (2/137) Grade 2, and 2.2% (3/137) Grade 1. Conclusions: Preliminary results with HDR implant alone compare favorably to EBRT, LDR +/- EBRT, and HDR + EBRT, both with regard to PSA disease free survival, and complications. By omitting EBRT, bladder and rectal complications appear to be significantly reduced. No significant financial relationships to disclose.
Fronto-Striatal Overactivation in Euthymic Bipolar Patients During an Emotional Go/NoGo Task
Authors: Michèle Wessa
Journal: American Journal of Psychiatry (2007)

Objective: Although euthymic bipolar patients show minimal manic and depressive symptoms, they continue to show impaired emotional regulation and cognitive functioning. Few studies have directly examined the interference of emotional information with cognitive processes and its underlying cerebral mechanisms in euthymic bipolar patients. The authors examined the emotional modulation of cognitive processes and its underlying neural mechanisms in euthymic bipolar patients. Method: Seventeen euthymic bipolar patients and 17 healthy comparison subjects underwent functional magnetic resonance imaging (MRI) while performing an emotional and nonemotional go/nogo task. Neural responses associated with the overall task performance, as well as with the impact of emotional information on the task performance, were assessed. Results: Bipolar disorder patients exhibited increased activity in the temporal cortex, specifically to emotional go/nogo conditions, as well as in the orbitofrontal cortex, the insula, the caudate nuclei, and the dorsal anterior and posterior cingulate cortices when inhibiting emotional stimuli compared with neutral stimuli. Conversely, no global attentional deficits were observed on either a behavioral or neural response level, indicated by similar task performances for all task conditions and similar brain activation patterns when comparing all the go/nogo conditions with the resting state. Conclusions: The present study provides evidence of an altered emotional modulation of cognitive processing in euthymic bipolar patients, indicated by an overactivation in ventral-limbic, temporal, and dorsal brain structures during emotional go/nogo conditions in patients relative to comparison subjects.
ANDROGENS FOR ANGINA
Authors: W. H. B.
Journal: Annals of Internal Medicine (1944)

Editorial1 March 1944ANDROGENS FOR ANGINAW. H. B.W. H. B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-3-539 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAndrogens for angina! Even the most stalwart of clinicians is bound to shudder when first confronted with such a seemingly paradoxical concept. Are we to abandon the time-honored therapeutic regimen for angina pectoris—rest, reduction of physical activity to a minimum, avoidance of emotional excitement, and nitroglycerine—in favor of "pep-shots" which have been credited with restoring to the senescent male vigor, energy, and a fresh lust for life? At first sight such an idea would seem fantastic, yet recent reports from several sources suggest that—far from being harmful—injections of testosterone propionate have proved highly beneficial to the stenocardiac.The first to...1 EDWARDSHAMILTONDUNTLEY EAJBSQ: Testosterone propionate as a therapeutic agent in patients with organic disease of the peripheral vessels, New England Jr. Med., 1939, ccxx, 865. CrossrefGoogle Scholar2 HERRMANMCGRATH MDEJ: The effect of estrogens in vascular spasm due to active angiitis in the extremities, Arch. Surg., 1940, xl, 334. CrossrefGoogle Scholar3 WALKER TC: (a) The use of testosterone propionate and estrogenic substance in cardiovascular disease: preliminary report, Med. Rec. and Ann., 1940, xxxiv, 667. (b) The use of testosterone propionate and estrogenic substance in the treatment of essential hypertension, angina pectoris, and peripheral vascular disease, Jr. Clin. Endocrinol., 1942, ii, 560-568. Google Scholar4 BONNELLPRITCHETTRARDIN RWCPTE: Treatment of angina pectoris and coronary artery disease with sex hormones, Ohio State Med. Jr., 1941, xxxvii, 554. Google Scholar5 LESSER MA: The treatment of angina pectoris with testosterone propionate. Preliminary report, New England Jr. Med., 1942, ccxxvi, 51-54. CrossrefGoogle Scholar6 LESSER MA: The treatment of angina pectoris with testosterone propionate. Further observations, New England Jr. Med., 1943, ccxxviii, 185-188. CrossrefGoogle Scholar7 HAMM L: Testosterone propionate in the treatment of angina pectoris, Jr. Clin. Endocrinol., 1942, ii, 325-328. CrossrefGoogle Scholar8 SIGLERTULGAN LHJ: Treatment of angina pectoris by testosterone propionate, New York State Jr. Med., 1943, xliii, 1424-1428. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1944Volume 20, Issue 3Page: 539-542KeywordsAndrogensAnginaEmotionsExercisePropionatesTestosterone ePublished: 1 December 2008 Issue Published: 1 March 1944 PDF downloadLoading ...
Errors in Abstract, Table, and Discussion
Journal: JAMA Network Open (2021)

Steven B. Heymsfield, MD; Laura A. Coleman, PhD, RD; Ram Miller, MD; Daniel S. Rooks, PhD; Didier Laurent, PhD; Olivier Petricoul, PhD; Jens Praestgaard, PhD; Therese Swan, PharmD; Thomas Wade, MD; Robert G. Perry, MD; Bret H. Goodpaster, PhD; Ronenn Roubenoff, MD, MHS
ADDITIONAL A. C. P. MEMBERS ENTER THE ARMED FORCES
Journal: Annals of Internal Medicine (1944)

College News Notes1 December 1944ADDITIONAL A. C. P. MEMBERS ENTER THE ARMED FORCESAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-6-1056 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. J. Roscoe Miller, F.A.C.P., Chicago, Dr. Gustavus A. Peters (Associate), Rochester, Minn., and Dr. Harry A. Senekjie (Associate), New Orleans, have recently entered the Armed Forces, bringing the total number of members on active military duty to 1,720.Lt. Comdr. James P. Jordan (Associate), (MC), USNR, of Buffalo, N. Y., died July 23, 1944.NEW LIFE MEMBERSThe College is gratified to announce that the following Fellows of the College became Life Members during the month of November:Dr. Thomas P. Murdock, Meriden, Conn.Dr. Delivan A. MacGregor, Wheeling, W. Va.Dr. Leon S. Gordon, Washington, D. C.GIFTS This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1944Volume 21, Issue 6Page: 1056-1080KeywordsArmed forces ePublished: 1 December 2008 Issue Published: 1 December 1944 PDF downloadLoading ...
Broadcasting Health.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Michelangelo's David
Authors: William H. Crosby
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Ciaglia (<b>218</b>:1304, 1971) asks: Why the Foreskin on Michelangelo's "David"? His answer ignores other evidence of Michelangelo's lack of concern for such anatomic niceties, for example, a belly button on the brand new Adam of the Sistine Chapel ceiling. And, in the Pietá, not only does the mother look younger than her son, but blood fills the arm veins of the crucified Christ. (What, no valves?) Had Michelangelo really been with it, he would not have put the spear wound at the traditional location above the liver, but, knowing that blood<i>and water</i>came from the wound, he would have placed it close to the symphysis pubis.
Pattern Recognition Analysis of a Set of Mutagenic Aliphatic N-Nitrosamines
Authors: Stephen Nesnow, Robert Langenbach, Marc J. Mass
Journal: Environmental Health Perspectives (1985)

A set of 21 mutagenic aliphatic N-nitrosamines were subjected to a pattern recognition analysis using ADAPT software. Four descriptors based on molecular connectivity, geometry and sigma charge on nitrogen were capable of achieving a 100% classification using the linear learning machine or iterative least squares algorithms. Three descriptors were capable of a 90.5% and two descriptors of a 85.7% overall correct classification. Three of the four descriptors were each capable of classifying 15 of the 16 active chemicals while it required three of the four descriptors to classify correctly two of the five inactive chemicals. These results are in concert with previous observations that molecular connectivity, geometry, and sigma charge on nitrogen are powerful descriptors for separating active from inactive mutagenic and carcinogenic N-nitrosamines.
Highlights
Journal: JAMA Dermatology (2015)

Atopic dermatitis (AD) is a common chronic infl ammatory dermatitis of the skin.The topical calcineurin inhibitors tacrolimus and pimecrolimus are some of the few topical agents that have been approved by the US Food and Drug Administration for the treatment of AD in children.An unfortunate risk associated with oral use of these agents is an increased risk of cancer.In this longitudinal cohort postmarketing surveillance study using the Pediatric Eczema Elective Registry (PEER), Margolis et al demonstrate that pimecrolimus use did not appear to be associated with an increased risk of cancer.
SCARLET FEVER—THE OUTLOOK
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Work Group Name in: Enteral Omega-3 Fatty Acid, γ-Linolenic Acid, and Antioxidant Supplementation in Acute Lung Injury
Authors: Hubert Vesper, Heather Kuiper, Lisa Mirel, Clifford Johnson, James Pirkle, Christina Waters, Judith Heitz, Tunde Meyers, Antoinette Smith, Ashley Ribera, Marcela Muresan, Ashley Tippins, Cindy Tse, Monir Clark
Journal: JAMA (2012)

56%: 24.3 µmol/L [95% CI, 19.6-29.0µmol/L]).Similar changes were seen in elaidic acid, palmitelaidic acid, and linoelaidic acid.The weighted geometric mean of the difference for the sum of all 4 TFAs was 54.1 µmol/L (95% CI, 43.4-64.7 µmol/L) or 58% lower in samples from 2009 compared with samples from 2000 (TABLE 2).Levels of LDL-C were lower in the samples from 2009 (119.2 mg/dL [3.09 mmol/L]) compared with the samples from 2000 (128.2 mg/dL [3.32 mmol/L]; Table 1).Comment.This study is, to our knowledge, the first time information on TFAs in white adults in the US population has been examined.Plasma levels of TFAs were substantially lower in 2009 than in 2000.This may lead to a decrease in risk for cardiovascular disease in this subpopulation.Because this study was limited to only 2 years and only a few parameters, it does not allow for detailed assessments of the association with LDL-C level or other factors.These findings provide preliminary data on white adults only and cannot be generalized to other racial/ethnic and age groups.Further studies to address these limitations are ongoing.
Are condoms the answer to rising rates of non-HIV sexually transmitted infection?
Authors: Markus J Steiner, Willard Cates, Stephen J Genuis
Journal: BMJ (2008)

Consistent condom use can reduce the spread of HIV, and <b>Markus Steiner and Willard Cates</b> believe condoms are the answer to other sexually transmitted infections. But <b>Stephen Genuis</b> argues that a more comprehensive approach is needed
Archivio per le Scienze Mediche, Turin
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Angiolipoma Detected by F-18 FDG Positron Emission Tomography
Authors: CHUNG-HUEI HSU, CHE-MING YANG, CHIEH-JUI CHENG
Journal: Clinical Nuclear Medicine (2003)

Angiolipomas, a variant of a typical lipoma, are not uncommon benign neoplasms composed of adipocytes admixed with abnormal angiomatous elements. The detection of angiolipomas by fluorodeoxyglucose (FDG) positron emission tomography (PET) has not been previously reported. A subcutaneous angiolipoma with intermediate increased accumulation of FDG was visible on a whole-body PET study. It is likely that hypervascularity, blood pooling in vascular structures with congested lumens, and accelerated inflammatory processes account for the imaging findings. This became evident during image interpretation and in determining whether the tumor was benign or malignant.
Polymorphisms for Aromatic Amine Metabolism in Humans: Relevance for Human Carcinogenesis
Authors: Fred F. Kadlubar, Mary Ann Butler, Keith R. Kaderlik, Hsien-Chang Chou, Nicholas P. Lang
Journal: Environmental Health Perspectives (1992)

The metabolic pathways associated with carcinogenic aromatic amines in humans provide an excellent example of polymorphisms that appear to be relevant to human carcinogenesis. In this regard, the N-acetylation of arylamines and the O-acetylation of their N-hydroxy metabolites are catalyzed preferentially by a genetically polymorphic acetyltransferase, high activity of which has been correlated with decreased risk for urinary bladder cancer and increased susceptibility to colorectal cancer. Cytochrome P450IA2, the principal liver enzyme involved in aromatic amine N-oxidation, exhibits a wide interindividual variation that appears trimodal in several populations and is clearly inducible by cigarette smoking and probably other host factors as well. UDP-Glucuronosyltransferases, which catalyze the N-glucuronidation of N-hydroxyarylamines and are likely to be responsible for their transport to the colon, show widely varied but unimodal distributions in humans. In contrast, human liver sulfotransferase activity for N-hydroxyarylamines, which would be expected to decrease their transport through the circulation, is catalyzed by a polymorphic enzyme(s) that is expressed at higher levels in blacks, as compared to whites, and could contribute to their relatively lower incidence of urinary bladder cancer. Peroxidative activation of aromatic amines can also occur, especially from prostaglandin H synthase in the urinary bladder and myeloperoxidase in the lungs of cigarette smokers, and both show considerable individual variability, apparently due to the extent of tissue inflammation.(ABSTRACT TRUNCATED AT 250 WORDS)
ARMED FORCES FACED WITH SURPLUS OF MEDICAL OFFICERS
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Reply:
Authors: I. Craig Henderson, Larry Norton, Donald A. Berry
Journal: Journal of Clinical Oncology (2003)

The Art of Oncology: When the Tumor Is Not the Target is a section within the Journal of Clinical Oncology.It has attracted a series of interesting and enjoyable articles.However, the title of the section refers to the divisions between biologic and nonbiologic care, rather than their integration, and likens biologic therapy to target eradication.Should the title be reconsidered?The title Simultaneous Care: Treatment and Palliative Care Throughout Disease 1 is representative of the theme and ethos of the articles within the section.It describes the improvement of patient well-being-be it biologic, psychological, social, or spiritual-at all stages of the course of disease.The article from which this title is quoted discusses integrated therapy, the communication between patients and doctors of the uncertainties associated with treatment outcome, and the role of clinical research.Many patients and fellow health professionals see oncologists as having a key responsibility in delivering and integrating care.The oncologist is in an authoritative position because of his or her knowledge and experience.Oncologists also understand the value of collaboration by the team of caregivers, as well as the influence of the doctor-patient relationship on all the aforementioned aspects of patient well-being.The title of the section should thus emphasize integration of therapies, rather than their divisions.The metaphor of target eradication for biologic therapy is military in nature and is not appropriate for therapy and healing.It arouses associations of victory or failure, collateral damage, and a "fight to the end."It is not an accurate reflection of conventional anticancer therapies, which have always included the need to make weighted decisions on the likely benefits and harms of therapy.In particular, it does not reflect developments in anticancer therapy, which is increasingly directed toward the understanding and regulation of biologic behavior.Are there alternative metaphors?The metaphor of art itself might be considered and the section titled The Art of Oncology only.Art is created through intelligent and skilful responses to the complexities of life and the world around us.It is vital and transforming.It is in a continuous process of development and study.It is individual but also resonates in the broader world.At its best, The Art Of Oncology will reflect the principles that emerge after working through the complexities of integrated patient care.Would such a metaphor add the much needed weight to nonbiologic aspects of patient care?It should, and one knows that the published articles will do so.Are there any other offers?