tbuckley/cabot-search huggingface dataset:
Industrial Microbiology: The Utilization of Bacteria, Yeasts and Molds in Industrial Processes.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Awards Appointments, Announcements
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Awards Appointments, Announcements Get access JNCI: Journal of the National Cancer Institute, Volume 81, Issue 7, 5 April 1989, Pages 480–481, https://doi.org/10.1093/jnci/81.7.480-a Published: 05 April 1989
Highlights from Recent Cancer Literature
Journal: Cancer Research (2013)

High-grade serous ovarian cancer has a poor prognosis for two main reasons: Most cases are detected at a late stage when there are disseminated peritoneal metastases, and after initial response to chemotherapy, 30% to 40% of patients experience a relapse within 12 months and are resistant to standard therapy.Were it possible to predict the outcome of therapy, oncologists might be able to give more targeted, personalized drugs or intensive chemotherapy to subsets of patients in this genetically heterogeneous disease.Yang and colleagues used reverse-phase protein arrays of 412 patient biopsies to construct a PROtein-driven index of OVARian cancer (PROVAR).A predictive set of nine protein markers was associated significantly with progression-free and overall survival.These nine proteins represent three major intracellular signaling pathways (STAT, PKC, and MEK/ERK) involved in cell proliferation, survival, and invasion.PROVAR was validated using a second cohort of 224 high-grade serous ovarian cancer patient biopsies, discriminating between high and low risk of recurrence after chemotherapy, as well as between short-term and long-term survivors.The protein array data were superior to gene expression-based classification of prognosis.Previous gene expression studies have shown that both mesenchymal and immunoreactive gene expression signatures were associated with a poor prognosis; the PROVAR protein signature was correlated with both these subgroups.Should this nine-protein signature be validated further, these outcomes could be measured by immunohistochemistry at the time of diagnosis.(Image courtesy of
Syringe and Needle Exchange as HIV/AIDS Prevention for Injection Drug Users
Authors: John K. Watters
Journal: JAMA (1994)

<h3>Objective.</h3> —To evaluate an all-volunteer syringe exchange program in San Francisco, Calif. <h3>Data Sources.</h3> —Syringe exchange program records and 11 semiannual surveys administered during a 5.5-year period, using standard questionnaires. Interviews (N=5644) were conducted with injection drug users recruited in two 21-day drug detoxification clinics and three street settings. <h3>Main Outcome Measures.</h3> —Use of the syringe exchange program and self-reported data regarding sources of syringes, frequency of injection, initiation into drug injection, and frequency of syringe sharing. <h3>Results.</h3> —In spring 1992, 45% reported "usually" obtaining injection equipment from the syringe exchange, and 61% reported using the program within the past year. During the period from December 1986 through June 1992, the median reported frequency of injection declined from 1.9 injections per day to 0.7 injection per day, the mean age increased from 36 to 42 years, and the percentage of new initiates into injection drug use decreased from 3% to 1%. In logistic regression analysis (of fall 1991 through spring 1992 interviews; n=752), we found six independent factors associated with syringe sharing. Protective from syringe sharing were use of the syringe exchange program, having received human immunodeficiency virus (HIV) testing and counseling, condom use, older age, and African-American race. Injection of cocaine was a predictor for syringe sharing. The strength of association between use of the syringe exchange program and not sharing syringes was greatest in injection drug users younger than the median age of 40 years. <h3>Conclusions.</h3> —The syringe exchange program was rapidly adopted by injection drug users. Health interventions associated with not sharing needles included use of the syringe exchange program and voluntary, confidential HIV testing and counseling. Our data did not support the hypothesis that a syringe exchange program would stimulate increased drug abuse in terms of frequency of injection or recruitment of new and/or younger users. (<i>JAMA</i>. 1994;271:115-120)
A Textbook of Laboratory Diagnosis with Clinical Applications for Practitioners and Students
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Access to Specialty Care
Authors: Jerome P. Kassirer
Journal: New England Journal of Medicine (1994)

Despite complaints that the care provided by specialists is discontinuous and fragmented, Americans have traditionally valued their unrestrained access to care by cardiologists, dermatologists, urologists, and other specialists. But now the rapid spread of managed care is dramatically changing how referrals to specialists are made. For example, most health maintenance organizations (HMOs) sharply limit access to specialists by interposing a “gatekeeper” physician between the patient and the specialist, and in the process many patients have lost an element of control over the kind of care they receive.The cost of specialty care is a principal concern. Specialists are more expensive . . .
Unconscious Therapeutics, or the Personality of the Physician.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Enhanced Natural Killer Sensitivity With Concomitant Clonal Selection for Cells Bearing Homogeneously Staining Regions in the Human Melanoma Cell Line MeWo Upon Induction of Differentiation With Theophylline&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1984)
Abstract 466: Tumor-induced fibrocytes mediate immune suppression via Indoleamine Oxidase.
Authors: Hua Zhang, Crystal L. Mackall
Journal: Cancer Research (2013)

Abstract Fibrocytes are hematopoietic stem cell-derived, fibroblast precursors implicated in chronic inflammation, fibrosis and wound healing, whereas human myeloid derived suppressor cells (MDSC) have been described as CD14-CD11b+CD33+HLADR- cells that exert T cell suppression via ROS, ARG1 and iNOS2. Here we report that patients with metastatic pediatric sarcomas have abnormal expansions of myeloid cells within elutriated mononuclear apheresis samples of pediatric cancer patients. Like myeloid derived suppressor cells, these cells are CD14-CD11b+, but they also cells bear markers of classical fibrocytes, including surface α smooth muscle actin, fibroblast activation protein, collagen I/V, and HLA-DR, but are PM2K negative. They also mediate angiogenesis and are CD33lo/-CD34+CD15+CD16+CD66b+CD68+PDL1+ and IL4Rα+. While classical fibrocytes serve as antigen presenting cells and augment immune reactivity, fibrocytes from cancer patients suppressed anti-CD3 mediated T cell proliferation, primarily via indoleamine oxidase (IDO). Interestingly the degree of fibrocyte expansion observed in individual patients directly correlated with the frequency of circulating GATA3+CD4+ cells (R=0.80) and monocytes from healthy donors cultured with IL-4 differentiated into fibrocytes with the same phenotypic profile and immunosuppressive properties as those observed in patients with cancer. We conclude that fibrocytes are a subset of myeloid derived suppressor cells expanded in cancer patients likely in response to Th2 immune deviation. These cells may contribute to tumor progression via both immune evasion and angiogenesis. Citation Format: Hua Zhang, Crystal L. Mackall. Tumor-induced fibrocytes mediate immune suppression via Indoleamine Oxidase. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 466. doi:10.1158/1538-7445.AM2013-466
Never Tell a Patient 'Never' About the Use of Radiographic Contrast Agents
Authors: G. David Dixon
Journal: JAMA (1982)

It has long been an irritation to me that, after a patient experiences contrast media "reactions," physicians or other paramedical personnel will advise him never again to allow radiographic contrast agents—dyes, if you will— to be injected into him. As a diagnostic radiologist, I have recently consulted with three patients who were told this. All of these patients needed contrast studies, and all were unduly concerned about the use of such agents because of previous admonitions by medical personnel. For example: <h3>Case 1.—</h3> A 58-year-old woman was to have a computed tomographic (CT) study of the cerebellopontine angle cistern to rule out an acoustic neuroma. Because of a rather strong allergic history, she had previously been told by a physician never to allow the injection of radiographic contrast agents, despite the fact that she had never had any such injection. After considerable explanation and reassurance on my part and telephone
Bacteriologic Diagnosis of Acute Pneumonia
Authors: Michael Davidson
Journal: JAMA (1976)

Bacteriologic analysis was performed on sputum, transtracheal aspirate (TA), and direct-needle aspirate of the lung (LA) obtained concurrently in each of 25 adult Navajo Indian patients with acute, community-acquired pneumonia. Although sputum reflected the organisms isolated from LA as frequently as did TA, multiple potential pathogens were recovered from all but five sputum specimens and from 27% of TA. Data collected suggest frequent tracheal contamination with potential pathogens and occasional multiple bacterial isolates from the LA of patients with acute pneumonia. Lung aspiration yielded single, definitive isolations more frequently than other sampling techniques did. (<i>JAMA</i>235:158-163, 1976)
Are Patients Shocked by ECT?
Authors: Jennifer Hughes, B M Barraclough, W Reeve
Journal: Journal of the Royal Society of Medicine (1981)

Seventy-two consecutive patients treated with electroconvulsive therapy (ECT) for severe mental illness were asked their opinions about ECT: 83% considered they had improved as a result of the treatment and 81% would have it again. Most found the experience neutral or pleasant and 54% thought the dentist more distressing. Claims in newspapers, magazines, television and elsewhere that ECT is cruel and frightening receive little support from the results of this study.
Klinefelter Syndrome and Cancer
Authors: Henry T. Lynch
Journal: JAMA (1974)

The well-established relevance of familial and evidently genetic factors for breast cancer in women may be generalized to all individuals whose chromosome complements include two X chromosomes. Thus, an individual with a masculine phenotype, whose chromosome complement includes a Y chromosome as well as two X chromosomes may face the same risk as his sisters who lack a Y chromosome. The familial (genetic?) factor for cancer diathesis determines a relatively high risk for breast cancer in an individual with two X chromosomes. The familial factor for cancer diathesis is transmitted to and through individuals of both sexes. The usually sex-limited (ie, to females) manifestations of the relevant familial factor is evidently not directly related to gender but rather to interaction with an effect of the occurrence of two X chromosomes. Further medical genetic studies of Klinefelter patients and their families seem warranted in order to better appraise cancer epidemiology. (<i>JAMA</i>229:809-811, 1974)
The Principles of Electrotherapy and Their Practical Application.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prophylaxis for Postoperative Deep-Vein Thrombosis
Authors: Vijay V. Kakkar
Journal: JAMA (1979)

Randomized clinical trials in 300 patients undergoing major abdominal surgery or hip replacement arthroplasty were performed to investigate the efficacy of dihydroergotamine mesylate, heparin calcium, or a combination of dihydroergotamine with heparin in preventing postoperative deep-vein thrombosis (DVT). The diagnosis of DVT was established by an uptake test using fibrinogen labeled with iodine 125; in patients undergoing hip replacement, phlebography was also employed to confirm or refute the presence of isotopic thrombi. The data indicate that the combination of dihydroergotamine and heparin is more effective than heparin or dihydroergotamine alone in preventing DVT. (<i>JAMA</i>241:39-42, 1979)
Recent Advances in Vaccine and Serum Therapy
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Soy Protein Diet
Authors: Mary Lou Johnston
Journal: JAMA (1982)

<h3>To the Editor.—</h3> In the report by Check entitled "Switch to Soy Protein for Boring but Healthful Diet" (1982; 247:3045) in the MEDICAL NEWS section, I would like to point out that a soy diet does not have to be boring. As the nutritionist for the metabolic study described, I developed four different menus for each of the three diets tested. The soy diet incorporated various soy products, including textured vegetable protein, tofu, soy flours, nuts and granules, and soybeans. Two sample soy menus are given in the Table. Menus were planned to meet the recommended dietary allowances<sup>1</sup>for this age group and to accommodate the taste preferences of young adult males. Overall, subjects found the meals to be satisfying and tasty. Monotony may have occurred during the 28-day feeding period because of the repetitious cycle and the highly controlled conditions. However, soy products are versatile, and only the imagination
An Introduction to Pathology and Morbid Anatomy.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cholesterol and Coronary Heart Disease
Authors: Scott M. Grundy
Journal: JAMA (1986)

SEVERAL important developments have recently given new impetus to prevention of coronary heart disease (CHD) through control of the plasma cholesterol level. Three advances have been particularly dramatic. First, the Nobel prize in medicine was awarded in 1985 to Drs Joseph Goldstein and Michael Brown for their discovery of cell-surface receptors for low-density lipoproteins (LDLs); their finding was fundamental to our understanding of how plasma cholesterol levels are controlled. Second, the Lipid Research Clinics (LRC) Coronary Primary Prevention Trial (CPPT)<sup>1</sup>reported that lowering of the plasma cholesterol level by bile acid sequestrants reduces the frequency of several manifestations of CHD, including myocardial infarction. And third, a new class of cholesterollowering drugs, namely, competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis, has been shown to markedly lower cholesterol levels.<sup>2-4</sup>Although these inhibitors are not yet approved for clinical use, they reveal the potential for
Duodenal Hematoma
Authors: ARI MINTZ, ANDREW ROSENSON, ARMANDO A. SALTIEL, AMJAD ALI, ERNEST W. FORDHAM
Journal: Clinical Nuclear Medicine (1991)

Enterogastric reflux occurs in normal and abnormal conditions. When pronounced, it is a nonspecific indicator of pathology. There are relatively few published reports discussing enterogastric reflux as a prominent finding on cholescintigraphy. A unique case of pronounced enterogastric reflux from an obstructing duodenal hematoma is presented.
Methadone Maintenance, Pregnancy, and Progeny
Authors: George Blinick
Journal: JAMA (1973)

Pregnancy was observed 105 times in narcotic-addicted women in the Methadone Maintenance Treatment Program of the Beth Israel Medical Center. There was no maternal mortality. Complications of pregnancy and fetal wastage were unremarkable. One third of the infants were premature by weight. Management in labor was modified only by the addition of methadone hydrochloride treatment. No serious effects attributable to methadone were seen in the neonatal period, and followup revealed normal growth and development.
Alopecia and amphetamine use
Authors: D. A. Voron
Journal: JAMA (1988)

<h3>To the Editor.—</h3> The excellent article by Harris et al<sup>1</sup>in the March 11 issue of<i>JAMA</i>effectively reinforces the body mass index (weight [kilograms]/height [meters] squared) as an independent risk factor for cardiovascular mortality among older persons. According to a recent report<sup>2</sup>from the National Center for Health Statistics, nearly 34 million adult Americans or more than one in four adults 20 to 74 years of age are overweight from estimates based on the body mass index. A panel of nutrition and epidemiologic experts at the 1985 National Institutes of Health Conference on the Health Implications of Obesity cited evidence that "obesity is clearly associated with hy