tbuckley/cabot-search huggingface dataset:
Dyazide® Composition
Authors: DAVID AKMAN
Journal: Annals of Internal Medicine (1976)

Comments1 December 1976Dyazide® CompositionDAVID AKMAN, M.D.DAVID AKMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-6-827_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I read with interest Dr. Knarr's comment (1) on impotence associated with the use of propranolol. His description of Dyazide® as triamterene is incorrect. Dyazide is a brand name of a compound containing 50 mg of triamterene and 25 mg of hydrochlorothiazide.It is difficult to understand why Dr. Knarr would choose a combination drug such as Dyazide to begin treatment of his hypertensive patient. His error shows one of the pitfalls of using such drugs; namely, the difficulty the physician has in remembering the ingredients of the combination compound....References1. KNARR J: Impotence from propranolol. Ann Intern Med 85:259, 1976 LinkGoogle Scholar2. Physicians Desk Reference. To Pharmaceutical Specialties and Biologicals. Oradell, New Jersey, Medical Economics, Inc., 1976, p. 1430 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Louisiana State University Medical Center 1542 Tulane Ave. New Orleans, LA 70112 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySynthesis of L-Ascorbic Acid 1 December 1976Volume 85, Issue 6Page: 827-827KeywordsDrugsErectile dysfunction Issue Published: 1 December 1976 PDF DownloadLoading ...
Cours élémentaire de dessin d'anatomie du squelette
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 10969: Intraventricular Conduction Delay in 12-lead Electrocardiogram Predicts Sudden Cardiac Death in General Population
Authors: Aapo L Aro, Olli Anttonen, Jani T Tikkanen, Juhani Junttila, Tuomas Kerola, Harri Rissanen, Antti Reunanen, Heikki V Huikuri
Journal: Circulation (2010)

Background: Prolonged duration of QRS complex (QRSd) in 12-lead electrocardiogram (ECG) is associated with adverse prognosis in patients with cardiac disease, but its significance is not well estab...
THE REAL PRESCRIBER.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lateral Epicondylitis: Occupational Hazard of Performing Spine Surgery
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevention of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline
Authors: Jadwiga A. Wedzicha, Peter M.A. Calverley, Richard K. Albert, Antonio Anzueto, Gerard J. Criner, John R. Hurst, Marc Miravitlles, Alberto Papi, Klaus F. Rabe, David Rigau, Pawel Sliwinski, Thomy Tonia, Jørgen Vestbo, Kevin C. Wilson, Jerry A. Krishnan
Journal: European Respiratory Journal (2017)

This document provides clinical recommendations for the prevention of chronic obstructive pulmonary disease (COPD) exacerbations. It represents a collaborative effort between the European Respiratory Society and the American Thoracic Society. Comprehensive evidence syntheses were performed to summarise all available evidence relevant to the Task Force9s questions. The evidence was appraised using the Grading of Recommendations, Assessment, Development and Evaluation approach and the results were summarised in evidence profiles. The evidence syntheses were discussed and recommendations formulated by a multidisciplinary Task Force of COPD experts. After considering the balance of desirable (benefits) and undesirable consequences (burden in the form of adverse effects and cost), quality of evidence, feasibility, and acceptability of various interventions, the Task Force made recommendations for mucolytic, long-acting muscarinic antagonist, phosphodiesterase-4 inhibitor (roflumilast) and macrolide therapy, as well as a conditional recommendation against fluoroquinolone therapy. All of the recommendations were conditional, except for a strong recommendation for the use of a long-acting antimuscarinic agent <i>versus</i> a long-acting β<sub>2</sub>-adrenergic, indicating that there was uncertainty about the balance of desirable and undesirable consequences of the intervention, and that well-informed patients may make different choices regarding whether to have or not have the specific intervention. The guideline summarises the evidence and provides recommendations for pharmacological therapy for the prevention of COPD exacerbations.
Abstract 1118: FOXQ1 stimulates WNT-signaling through transcriptional activation of WNT5B to promote the epithelial to mesenchymal transition
Authors: Allison V. Mitchell, Guojun Wu
Journal: Cancer Research (2019)

Abstract Aberrant induction of the epithelial to mesenchymal transition (EMT) is an acknowledged mechanism of acquired metastatic competence and drug resistance in many epithelial cancer types. Both physiological and pathological forms of EMT are thought to occur through a network of transcription factors (TFs) that drive cell plasticity and the acquisition of stem-like traits. The forkhead box transcription factor, FOXQ1, is a potent driver of EMT. FOXQ1 has been shown to be specifically upregulated in the triple negative subtype of breast cancer (TNBC) where is it associated with worse clinical prognosis. However, the role of FOXQ1 within the EMT transcriptional network has not been extensively characterized. In this study, we employed chromatin immunoprecipitation and RNA sequencing in a human mammary luminal epithelial cell line with ectopic FOXQ1 (HMLE/FOXQ1), as a model of breast EMT. We identified FOXQ1 localization within the promoter regions of prominent EMT-TFs, including TWIST1, ZEB1, FOXC2 and SIX2. Further, FOXQ1 direct gene targets are enriched in signaling pathways previously associated with EMT, including the WNT-signaling pathway. Within the WNT pathway, the WNT5B signaling ligand was a direct target for transcriptional activation by FOXQ1. Gene expression analysis in a panel of breast cancer cell lines revealed both FOXQ1 and WNT5B are enriched in the basal B subtype of TNBC. FOXQ1 and WNT5B expression were also found to be upregulated and correlated downstream of TGFβ induced EMT. Disruption of WNT5B expression attenuated EMT-associated stem-like traits, including decreases in mammosphere formation and in the CD44+/CD24- population, and significantly reduced cell invasion. Analysis of breast cancer gene expression from the TCGA revealed that FOXQ1 and WNT5B expression are correlated across all breast samples (r=0.46) and differentially upregulated in ER- breast cancer. Additionally, both FOXQ1 and WNT5B expression were associated with worse recurrence-free survival. Our data supports that WNT5B is a critical FOXQ1 target for mediating EMT features and suggests that disrupting the FOXQ1-WNT5B axis could be a potential strategy to target the EMT cell population in TNBC patients. Citation Format: Allison V. Mitchell, Guojun Wu. FOXQ1 stimulates WNT-signaling through transcriptional activation of WNT5B to promote the epithelial to mesenchymal transition [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1118.
Landmark perspective: Inactivated poliomyelitis vaccination. Issues reconsidered
Authors: E. R. Alexander
Journal: JAMA (1984)

It is difficult to look back at an important scientific contribution and to assess the full significance of the work. It must be evaluated in relation to the time in which it was written. What were its roots? What was the notable contribution of this work? Furthermore, where did it lead us? Only with that precious gift of knowing what really happened can we now look back and assess the broader significance of the contribution. Thus, we can examine the important article, "Considerations in the Preparation and Use of Poliomyelitis Vaccine," by Jonas Salk, published inThe Journalin August 1955.<sup>1</sup> <h3>First Polio Vaccine</h3> In that year, there was an urgent problem, and this article represented one important response. Salk had been the first to take advantage of the basic contribution of Enders et al<sup>2</sup>in the propagation of poliovirus in non-neural tissue cultures and produced a formalininactivated
Commentaire du travail de Napoléon B et al., pp. 26
Journal: Endoscopy (2014)

Bertrand Napoléon, Anne-Isabelle Lemaistre, Bertrand Pujol, Fabrice Caillol, Damien Lucidarme, Raphaël Bourdariat, Blandine Morellon-Mialhe, Fabien Fumex, Christine Lefort, Vincent Lepilliez, Laurent Palazzo, Geneviève Monges, Bernard Filoche, Marc Giovannini. A novel approach to the diagnosis of pancreatic serous cystadenoma: needle-based confocal laser endomicroscopy.
Antibiotic-associated colitis--the continuing saga.
Journal: BMJ (1981)

seminar, though they have equal access to funds in the locally organised research scheme and presumably encounter similar problems to those of hospital doctors.Understandably, the seminar was better at identifying problems than at suggesting solutions, but a few kites were flown.The attitudes of NHS managers and of health authority members may be difficult to change, but one plan that would enhance the status of NHS research would be the hypothecation of specified sums for research purposes only from the money being redistributed under the RAWP scheme and linked to a system of monitoring the quality of work done.Another, more forceful suggestion was that the present permissive powers of health authorities to provide background support for clinical research should become mandatory and might be linked to the designation of a certain number of NHS beds for research purposes.Yet perhaps the most important contribution of the seminar was simply the opening up of these issues for debate, and the Oxfordshire Research Committee is to be applauded for its initiative.
Final results of a phase II study of weekly trastuzumab and vinorelbine in chemonaive patients with HER2-overexpressing metastatic breast cance
Authors: G. Bernardo, R. Palumbo, A. Bernardo, G. Villani, M. Melazzini, G. Poggi, M. Frascaroli, I. Jedrychowska
Journal: Journal of Clinical Oncology (2004)

731 Background: Activity of Trastuzumab (T) and Vinorelbine (VNR) in patients (pts) with HER2+ metastatic breast cancer (MBC) has bene recently reported. Methods: Consecutive pts with histologically confirmed, measurable MBC, tumors scored as +3 positive for HER2 by immuno-histochemistry or FISH+, no prior chemotherapy for the metastatic disease entered the study after written informed consent. Eligible pts received i.v. T (4 mg/Kg loading dose as a 90'infusion, then 2 mg/kg weekly in 60') followed by VNR (25 mg/m2 weekly as 10' infusion, with dose adjusted according to haematologic toxicity), without a break, with one cycle consisting of 4 consecutive weeks. Results: Forty-eight pts have been treated: median age 53 years (range 32–70); prior adjuvant chemotherapy in 52%; prior hormonal therapy in 35%; most pts (84%) had visceral metastases (liver 52%, lung 32%); all were evaluable, having completed at least 2 cycles of treatment. A total of 186 cycles were given (median 4 per patient, range 1–16). VNR dose was reduced by 25% in 13% of weekly administrations and delayed by 1–2 weeks because of WHO grade 3 neutropenia; there were no dose adjustments for T. The worst hematological toxicity was WHO grade 4 neutropenia (8% of pts, 7% of cycles); no G-CSF support was used. A single episode of febrile neutropenia occurred, resolved without complications. Non-hematologic side effects were acceptable, with WHO grade 1 fatigue, alopecia, nausea/vomiting; cardiac and neurologic toxicity was mild. An objective response rate (RR) of 86% was observed, with 5 CRs, (3 in the lung, 2 in the liver) and 36 PRs (17 in the liver, 15 in the lung and 4 in the bone); 4 pts had SDs and 2 pts progressed while on treatment. The median time to response was 8 weeks, the median response duration was 9 months (range 3–14). Conclusions: Our results confirm that T plus VNR combination is a well tolerated and very active regimen as first-line treatment in this patient population. The optimal timing and duration of such a schedule need to be investigated in randomized trials. No significant financial relationships to disclose.
Evidence for cerebral dysfunction in people after the Camelford water incident
Journal: BMJ (1999)

Evidence for cerebral dysfunction in people after the Camelford water incident Just over 11 years ago 20 tonnes of aluminium sulphate were accidentally added to the drinking water reservoir serving 20 000 people in the Camelford area of Cornwall.There was delay in reporting the incident to the public, and those exposed started reporting various acute symptoms.Later, they started complaining of loss of concentration and short term memory, but in two sittings of a commission of inquiry their symptoms were attributed to anxiety.On p 807 Altmann et al report the results of studies done on 55 affected people who showed objective evidence of cerebral dysfunction.Anxiety levels had no effect, and unexposed siblings performed normally.Although no measures were available from before the incident, their accounts and the discrepancy with their premorbid IQ suggest that these individuals were affected by the incident, and it is likely that aluminium, as the major neurotoxic agent involved, led to the changes observed.
Black Rage
Authors: Marjorie C. Meehan
Journal: JAMA (1968)

Do riots and demands for black power make you angry? Do you wonder why Americans of African descent haven't solved their problems the way other ethnic groups have? Are you puzzled that people usually called Negroes now speak of themselves as blacks? Is it hard to understand your black patients or colleagues? Are you concerned with urban problems? If you answer "Yes" to any of these questions, you should read this book, even though it may make you uncomfortable. In it, two black psychiatrists, utilizing personal experience, knowledge of history, and clinical study of patients, analyze the problems of Negroes today, and show why the blacks are angry. Dr. Grier and Dr. Cobbs discuss many aspects of Negro life. They comment, "There is a grain of truth in every stereotypical canard" tossed at the Negroes, but show how these traits and many others have developed. Everyone agrees that many problems
Ultrasonic imaging of the abdomen. Report of the ultrasonography task force. Council on Scientific Affairs, American Medical Association
Journal: JAMA (1991)

As new imaging modalities emerge and existing technologies improve, indications for a particular imaging method may change. This article examines current indications for abdominal and prostatic ultrasound examination and, where possible, compares ultrasound with other imaging techniques. This is not an attempt to list all possible ultrasound indications or examinations, but rather an attempt to serve as an aid to informed imaging selection based on current literature and equipment.
OSSIFYING HEMATOMA
Authors: C. A. STONE
Journal: JAMA (1926)

There have come to my attention several instances of a pathologic condition usually classified as "Myositis Ossificans Traumatica." Since this is rather uncommon, it is deemed proper to report cases and experiments which may help clarify the subject. After reading much of the fairly extensive literature which is indexed variously as "myositis ossificans traumatica," "myositis ossificans circumscripta," "ossifying hematoma," etc., no satisfactory explanation for the lesion was found. There are a number of very good articles and several careful reviews on the subject.<sup>1</sup>Painter<sup>2</sup>reports a case and discusses thoroughly the various theories. The important references are also given. Noble,<sup>3</sup>still later, published a very carefully prepared article. These are among the more recent ones. It would be a waste of time to consider all the theories of causation. If due to periosteal transplants, as held by many, then, following fractures, this ossifying condition should be quite
Evaluating Patients With Persistent Chest Pain and No Obstructive Coronary Artery Disease—Reply
Authors: Anita Phan
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
VARIATIONS IN BLOOD PRESSURE
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of circulatory shock with dopamine. Studies on survival
Authors: C. E. Ruiz
Journal: JAMA (1979)

Therapeutic effects of dopamine hydrochloride on the peripheral and metabolic defects of shock were investigated in 34 patients with circulatory shock associated with myocardial infarction, bacteremia, or hypovolemia. Severity of the circulatory defect characterized by hypotension, reduced cardiac output, oliguria, and notably reduced skin (toe) temperature before treatment with dopamine was not directly related to survival. However, the arterial blood concentration of lactate before treatment with dopamine indicated the likelihood of survival. Patients who ultimately survived following treatment with dopamine had normal or only mildly elevated levels of arterial blood lactate before therapy. No patients with established shock states in whom perfusion failure was associated with substantial increases in the level of arterial blood lactate survived regardless of treatment with dopamine. Increases in toe temperature during dopamine treatment also emerged as a uniquely good indicator of favorable outcome during therapy. (<i>JAMA</i>242:165-168, 1979)
Evolution Of Acute Myelogenous Leukemia Stem Cell Properties Following Treatment and Progression
Authors: TzuChieh Ho, Mark W LaMere, Kristen O'Dwyer, Jason H. Mendler, Jane L. Liesveld, Meir Wetzler, Eunice S. Wang, Monica L. Guzman, Craig T. Jordan, Michael W. Becker
Journal: Blood (2013)