tbuckley/cabot-search huggingface dataset:
Online CME to Begin in Mid-2003
Authors: Michiaki Fukui, Yoshihiro Kitagawa, Naoto Nakamura, Toshikazu Yoshikawa
Journal: JAMA (2003)

Results.Of the 210 diabetic patients, 31 (14.8%) were positive for anti-HCV.Most clinical characteristics of patients with (n=31) and without (n=179) HCV infection were not statistically different (mean [SD] age, 65.6 [6.1] vs 65.2 [6.8] years; BMI, 22.7[3.2]vs 23.3[3.7];duration of diabetes, 10.4 [8.4] vs 9.0 [9.0] years; glycohemoglobin level, 7.7% [1.7%] vs 7.4% [1.1%]; C-reactive protein level, 0.20 [0.08] vs 0.18 [0.07] mg/ dL; presence of hypertension, 48.4% vs 41.9%; history of cigarette smoking, 38.7% vs 30.7%).However, significantly fewer patients with HCV infection had hyperlipidemia (32.3% vs 43.0%, P=.01).Mean (SD) IMT was significantly greater in patients with anti-HCV (1.03 mm [0.25 mm] vs 0.94 mm [0.23 mm], P=.04), as was median (interquartile range) plaque score (4.78 [2.48-7.19]vs 1.59 [0-4.57],PϽ.001 by the Mann-Whitney U test).Presence of any plaque was also significantly higher in those with anti-HCV (PϽ.001 by the Fisher exact test).Seropositivity for HCV was an independent risk factor (␤=.358, PϽ.001) for atherosclerosis (plaque score) after adjustment for age, hypertension, hyperlipidemia, smoking history, and glycohemoglobin level.Comment.Despite our small sample size, we found a statistically significant association between HCV positivity and ultrasonographic evidence of carotid atherosclerosis among patients with type 2 diabetes.Prospective, large-scale studies are needed to assess the association between HCV infection and atherosclerosis.Clinical studies have shown that serum concentrations of hepatocyte growth factor (HGF) and interleu-kin 6 (IL-6) are increased in patients with chronic hepatitis C infection, most likely as a result of HCV-induced inflammation. 5Although we did not measure concentrations of HGF or IL-6, our results are compatible with associations demonstrated between increased serum HGF and IL-6 concentrations and atherosclerosis.
An outbreak of Providencia stuartii urinary tract infections. Patients with condom catheters are a reservoir of the bacteria
Authors: J. Fierer
Journal: JAMA (1981)

We investigated an outbreak of multiple antibiotic-resistant<i>Providencia stuartii</i>urinary tract infections that occurred on a neurology ward. Only patients who had been catheterized became infected. However, approximately 10% of patients with condom catheter urinary drainage systems were colonized, ie,<i>P stuartii</i>was present on their skin and in the urine drainage bags but not in fresh-voided urine. Patient urinals were also contaminated. The outbreak was terminated by segregating infected and colonized patients from other patients who required either external or indwelling urinary catheters and by stopping the practice of exchanging urinals among patients. (<i>JAMA</i>1981;245:1553-1555)
SPARTEINE AND NITROGLYCERINE IN MORPHIA HABIT.
Journal: JAMA (1887)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Research Strategies for Behavioral Teratology Studies
Authors: Lester D. Grant
Journal: Environmental Health Perspectives (1976)

Several compelling aruguments have been advanced in support of expanding the use of "behavioral teratology" evaluations as routine components of toxicologic screening procedures. As a basis for development of effective behavioral teratology screening approaches, a conceptual framework is presented which interrelates: (1) changes in relative functional brain capacity with age, (2) possible times and durations of exposures to environmental insults, and (3) various types of toxicity testing procedures carried out at appropriate time points in relation to different exposure period. Within the context, several research strategies for behavioral teratology studies are concisely posed and evaluated. These include: (1) clinical hypothesis testing, where particular effect(s) of a given agent are evaluated based on hypotheses derived from clinical or epidemiological observations; (2) comprehensive screening approaches, where multifaceted, long-term longitudinal neurobehavioral evaluations are employed to assess whether any of a large number of possible deletarious effects are exerted by an agent and at what threshold exposure levels; (3) alternative screening heuristics, by which adequate assessments of neurobehavioral toxicity of various agents may be accomplished without completion of more exhaustive, but also more expensive and time-consuming comprehensive screening protocols.
Partitioning and Lipophilicity in Quantitative Structure-Activity Relationships
Authors: John C. Dearden
Journal: Environmental Health Perspectives (1985)

The history of the relationship of biological activity to partition coefficient and related properties is briefly reviewed. The dominance of partition coefficient in quantitation of structure-activity relationships is emphasized, although the importance of other factors is also demonstrated. Various mathematical models of in vivo transport and binding are discussed; most of these involve partitioning as the primary mechanism of transport. The models describe observed quantitative structure-activity relationships (QSARs) well on the whole, confirming that partitioning is of key importance in in vivo behavior of a xenobiotic. The partition coefficient is shown to correlate with numerous other parameters representing bulk, such as molecular weight, volume and surface area, parachor and calculated indices such as molecular connectivity; this is especially so for apolar molecules, because for polar molecules lipophilicity factors into both bulk and polar or hydrogen bonding components. The relationship of partition coefficient to chromatographic parameters is discussed, and it is shown that such parameters, which are often readily obtainable experimentally, can successfully supplant partition coefficient in QSARs. The relationship of aqueous solubility with partition coefficient is examined in detail. Correlations are observed, even with solid compounds, and these can be used to predict solubility. The additive/constitutive nature of partition coefficient is discussed extensively, as are the available schemes for the calculation of partition coefficient. Finally the use of partition coefficient to provide structural information is considered. It is shown that partition coefficient can be a valuable structural tool, especially if the enthalpy and entropy of partitioning are available.
Role of the university president in governance of the medical school
Authors: S. S. Atwood
Journal: JAMA (1968)

Undoubtedly, there are moments when any one of us would like to deny that a university president has any role whatsoever in the governance of a medical school. This feeling could prevail whether we are functioning as faculty, administrators, trustees, or public-at-large, although such doubting is of course, by tradition, the special prerogative of faculty members. On the other hand, we must assume the antithetical premise, and then try to determine how the president's role can be defined, limited, or even maximized. As a guide to reaching whatever consensus there may be on this subject, I will first ask and then propose answers to six questions. If you agree with my formulation of the questions and my tentative answers to them, at least we will be in tune with each other on some of the basic propositions related to present-day governance of medical schools and, therefore, in a better position
Detection, Prevention and Management of Urinary Tract Infections
Authors: Anand P. Panwalker
Journal: JAMA (1980)

Dr Kunin's enormous experience and expertise are reflected in this delightful hardcover version of a book that became popular when it first appeared in 1972. The book is divided into six sections, each one offering a wealth of information on the epidemiology, diagnosis, management, and sequelae of urinary tract infections in carefully defined patient populations. The chapters are well written and illustrated. The intent of the original pocket-size manual was "to provide health workers some practical information on 'how to do it' rather than to be a scholarly repository of information." The author is both practical and scholarly in this third edition. Hundreds of references at the end of the book, listed alphabetically under various subheadings, are easy to locate as one reads the text. I was pleased to see that numerous references were as current as 1978. As in most fields of medicine, controversies exist about the pathogenesis and
Frozen section in surgery.
Journal: BMJ (1967)

OUR61Larsen10 noted improvement in 16 out of 34 cases.The patients had a variety of disorders, including chronic idiopathic thrombocytopenic purpura, systemic lupus erythematosus, nephrotic syndrome, haemolytic anaemia, and Goodpasture's syndrome.The observation that platelet counts in four out of seven cases of thrombocytopenic purpura rose during treatment is of interest, since toxic depression of normal levels is a recognized hazard of treatment.910 W. E. Grupe and W. Heymann" have also reported improvement, in selected children suffering from steroid-resistant renal disease, after treatment with azathioprine, cyclophosphamide, or chlorambucil.In discussing the mode of action of cytotoxic drugs in "autoimmune" diseases these workers refer not only to the suppression of immune responses but also to the anti-inflammatory effect which has been observed in rabbits,'2 suggesting that both may play a part.That the small lymphocyte has a role in immune mechanisms is undisputed.Sir Macfarlane Burnet has suggested that its main function is " the carriage of immuno- logical information.""13The diminished intensity with which lymphocytes infiltrate tissues under the influence of cytotoxic agents is interpreted as evidence that the retardation of homograft rejection observed in man,3 and of the onset of auto- immune glomerulonephritis in susceptible mice,"4 is due to the suppression of immune responses.On the other hand, C. D. West and colleagues found cyclophosphamide to be less effective in the treatment of persistent hypocomplementaemic glomerulonephritis" than in " lipoid " nephrosis.8In the hypocomplementaemic disease the lowered levels of serum beta-lc-globulin and the presence of immune globulin deposits in glomeruli are evidence of immunological disturbance,'5 16 while in "lipoid " nephrosis there is no
Erratum
Journal: BMJ (1892)

Dc. 10, 18 it is naturally an embodiment of his views, and, although we notice with satisfaction that it has been very carefully rewritten, the subject matter is essentially the same.The most notable part is the paragraph on stricture of the urethra.The results obtained by Mr. Bruce Clarke and the authors entitle them to believe themselves exceptionally fortunate-and there will be found those who regard the operation as involving elements of danger and uncertainty.
Erratum to: Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers
Authors: Pedro Veliça, Nicholas J Davies, Pedro P Rocha, Heinrich Schrewe, Jonathan P Ride, Chris M Bunce
Journal: Molecular Cancer (2010)

CorrectionIt has come to our attention that since publication of our article [1], in the body of the article the term androstenedione has been used in error.The experiments in this study used androstanedione as a test substrate.Androstenedione was not used in any experiments.This error does not in any way invalidate the conclusion of the paper that aldo-keto reductases of the mouse and human 1C-subfamilies lack functional and expression homology.The authors apologise for any confusion caused.
Laparoscopic myolysis
Authors: J Donnez, J Squifflet, R Polet, M Nisolle
Journal: Human Reproduction Update (2000)

This review will focus on the different techniques and the long-term effects of the technique called myolysis on myoma growth. Indications for myolysis are essentially pelvic pain, compression symptoms and global uterine volume in order to avoid hysterectomy. In the late 1980s, myolysis was performed laparoscopically with the help of the neodynium: yttrium aluminium garnet (Nd:YAG) laser. Later, bipolar needles were developed as an alternative to the Nd:YAG laser. Diathermy and cryomyolysis were also proposed but series are small in the literature. Very recently, myoma interstitial thermo-therapy (MITT) was performed using the diode laser and a specific optical light diffuser that is designed to transmit laser light in all directions. Laparoscopic myolysis was proved to be effective in provoking myoma shrinkage, with a dramatic decrease in size and a marked devascularization of the myoma and this technique can be proposed as an alternative to myomectomy in selected patients: only those aged >40 years or those not desiring to bear any more children.
Treatment of vein graft stenosis by balloon catheter dilation
Authors: J. R. Alpert
Journal: JAMA (1979)

Percutaneous balloon catheter dilation was used to treat 12 high-grade stenoses in ten autogenous vein bypass grafts since September 1978. Four lesions occurred in femoropopliteal grafts, seven in femorotibial grafts, and one in an axillofemoral graft. Balloon catheter dilation was successful and surgery avoided in 11 of the 12 lesions. Pedal pulses were restored in eight of the ten patients, and the pulse in a femorotibial bypass graft was improved in another. Postdilation arteriography demonstrated a substantial increase in luminal diameter, and ankle pressure indexes were improved in all successful cases. The tenth had an operative correction of the stenosis. There were no complications with the procedure. Percutaneous balloon catheter dilation appears to be an effective method of treating stenosis in autogenous vein grafts and a useful alternative to surgical revision. (<i>JAMA</i>242:2769-2771, 1979)
The purity of cholestyramine resin
Authors: M. R. Goldstein
Journal: JAMA (1989)

<h3>To the Editor. —</h3> The suit filed by Warner - Lambert Company, Morris Plains, NJ, on March 21, 1989, against chemical company Rohm &amp; Haas, Philadelphia, Pa, has profound and far-reaching implications. It accuses Rohm &amp; Haas of negligence, breach of contract, and wanton and reckless conduct (<i>The Philadelphia Inquirer</i>. March 23, 1989: 1-C, 13-C) regarding the sale of pesticide-contaminated cholestyramine resin. Two pharmaceutical companies in this country have used cholestyramine resin manufactured by Rohm &amp; Haas for the manufacture of cholesterol-lowering drugs. Bristol-Myers US Pharmaceutical Group, Evansville, Ind, supplies cholestyramine resin in the form of a powder, Questran, and Warner-Lambert supplies cholestyramine resin in the form of a chewable bar, Cholybar. Questran has been available for approximately 20 years and Cholybar was released recently, in November 1988. In May 1988, Bristol-Myers, under an agreement with the Food and Drug Administration, recalled 200 million doses of Questran contaminated with pesticides (<i>The Philadelphia</i>
Comparative Investigations on the Effects of Androgenic Steroids on Adrenal Functions in Juvenile Asthmatic Soldiers
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A new treatment regime for facial angiofibromas in patients with tuberous sclerosis complex
Journal: British Journal of Dermatology (2020)

Tuberous sclerosis complex (TSC) is a genetic disorder affecting approximately one in every 6,000 to 10,000 people.The disease causes hamartomas, which are non-cancerous growths, to develop in many parts of the body.Facial growths that are composed of blood vessels and fibrous tissues, called facial angiofibromas (FAs), occur in up to 80% of TSC cases and cause significant distress to the patients.This study, from Taiwan, aimed to find out if a new treatment regime using two topical (applied to the skin) medicines, rapamycin and calcitriol, in combination would be an effective and safe treatment for TSC-related FAs.We enrolled 52 TSC patients with FAs who were assigned to apply either topical rapamycin (0.1%) or calcitriol (0.0003%) single-agent therapy (on its own) to one side of the face, and the two medicines as a combined treatment regime to the other side of the face, for 12 weeks.The patients were reassigned to use the ointment which worked best for another 12 weeks, and the treatment was then discontinued for 12 weeks.We evaluated the improvement of FAs by comparing the modified Facial Angiofibroma Severity Index (mFASI; score 0-10), which was calculated by the sum of erythema, meaning redness (0-3), papule (a raised area of skin tissue) size (0-3), papule elevation (0-3), and extent of lesions (0-1), at weeks 12 (used as the primary outcome), 24, and 36 from baseline (the start of the trial).We found that the mean reduction of mFASI at week 12 compared to baseline was -0.92 and -1.09 for rapamycin and rapamycin-calcitriol combination, respectively.Compared to rapamycin alone, extended use of the rapamycin/calcitriol combination regimen for 24 weeks showed more effectiveness in decreasing papule elevation and could maintain a longer improvement after stopping treatment.We concluded that topical rapamycin/calcitriol combination therapy is an effective and safe regimen for TSC-related FAs.
Cost-effectiveness of Homocysteine-Lowering Therapy to Prevent Coronary Heart Disease
Authors: Andrew G. Bostom
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LUDWIG COURVOISIER (1843-1918) COURVOISIER'S SIGN
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TennCare-Reply
Authors: David M. Mirvis
Journal: JAMA (1996)

<h3>In Reply.</h3> —We take pleasure in responding to comments elicited by our article. Drs Himmelstein and Woolhandler report a lower rate of insurance coverage in Tennessee than we did. Our data were derived from state reports. A University of Tennessee survey in August 1994 also reported an uninsured rate of 5.9%, a fall from 9% in 1993 before TennCare. TennCare enrollment currently includes more than 400 000 previously uninsured citizens.<sup>1</sup>Thus, TennCare did have a positive effect on coverage. Differences in quantitative values from those of other surveys are likely the result of methodologic differences, not the more pejorative reason of "sleight of hand." Dr Gore raises several issues that reflect differences of position more than inaccuracies. Whether a 60% response rate of initial enrollment was high or low is clearly one of perspective. We agree with the recent report by the Henry J. Kaiser Family Foundation and the
Twenty-Ninth Annual Postgraduate Institute for Pathologists in Clinical Cytopathology
Journal: JNCI Journal of the National Cancer Institute (1987)

Twenty-Ninth Annual Postgraduate Institute for Pathologists in Clinical Cytopathology JNCI: Journal of the National Cancer Institute, Volume 79, Issue 2, August 1987, Page 401, https://doi.org/10.1093/jnci/79.2.401-d Published: 01 August 1987