tbuckley/cabot-search huggingface dataset:
Low Utilization of Lead Extraction Among Patients With Infective Endocarditis and Implanted Cardiac Electronic Devices
Authors: Christopher T. Sciria, Edward V. Kogan, Ari G. Mandler, Ilhwan Yeo, Matthew S. Simon, Luke K. Kim, James E. Ip, Christopher F. Liu, Steven M. Markowitz, Bruce B. Lerman, George Thomas, Jim W. Cheung
Journal: Journal of the American College of Cardiology (2023)
Pathways driving tendinopathy and enthesitis: siblings or distant cousins in musculoskeletal medicine?
Authors: Lindsay A N Crowe, Moeed Akbar, Robert-Jan de Vos, Paul D Kirwan, Michael Kjaer, Carles Pedret, Iain B McInnes, Stefan Siebert, Neal L Millar
Journal: The Lancet Rheumatology (2023)
Early infection risk in patients with systemic lupus erythematosus treated with rituximab or belimumab from the British Isles Lupus Assessment Group Biologics Register (BILAG-BR): a prospective longitudinal study
Authors: Mia Rodziewicz, Sarah Dyball, Mark Lunt, Stephen McDonald, Emily Sutton, Ben Parker, Ian N Bruce
Journal: The Lancet Rheumatology (2023)
Readiness for implementation of novel digital health interventions for postoperative monitoring: a systematic review and clinical innovation network analysis
Authors: Kenneth A McLean, Stephen R Knight, Thomas M Diehl, Chris Varghese, Nathan Ng, Mark A Potter, Syed Nabeel Zafar, Matt-Mouley Bouamrane, Ewen M Harrison
Journal: The Lancet Digital Health (2023)

An increasing number of digital health interventions (DHIs) for remote postoperative monitoring have been developed and evaluated. This systematic review identifies DHIs for postoperative monitoring and evaluates their readiness for implementation into routine health care. Studies were defined according to idea, development, exploration, assessment, and long-term follow-up (IDEAL) stages of innovation. A novel clinical innovation network analysis used coauthorship and citations to examine collaboration and progression within the field. 126 DHIs were identified, with 101 (80%) being early stage innovations (IDEAL stage 1 and 2a). None of the DHIs identified had large-scale routine implementation. There is little evidence of collaboration, and there are clear omissions in the evaluation of feasibility, accessibility, and the health-care impact. Use of DHIs for postoperative monitoring remains at an early stage of innovation, with promising but generally low-quality supporting evidence. Comprehensive evaluation within high-quality, large-scale trials and real-world data are required to definitively establish readiness for routine implementation.
Artificial intelligence for tumour tissue detection and histological regression grading in oesophageal adenocarcinomas: a retrospective algorithm development and validation study
Authors: Yuri Tolkach, Lisa Marie Wolgast, Alexander Damanakis, Alexey Pryalukhin, Simon Schallenberg, Wolfgang Hulla, Marie-Lisa Eich, Wolfgang Schroeder, Anirban Mukhopadhyay, Moritz Fuchs, Sebastian Klein, Christiane Bruns, Reinhard Büttner, Florian Gebauer, Birgid Schömig-Markiefka, Alexander Quaas
Journal: The Lancet Digital Health (2023)
Evaluation of BMS-986142, a reversible Bruton's tyrosine kinase inhibitor, for the treatment of rheumatoid arthritis: a phase 2, randomised, double-blind, dose-ranging, placebo-controlled, adaptive design study
Authors: Philip G Conaghan, Miroslawa Nowak, Shuyan Du, Yi Luo, Jessica Landis, Chahin Pachai, Aberra Fura, Ian M Catlett, Dennis M Grasela, Mikkel Østergaard
Journal: The Lancet Rheumatology (2023)
A detailed mechanism of degradation behaviour of biodegradable as-ECAPed Zn-0.8Mg-0.2Sr with emphasis on localized corrosion attack
Authors: Jan Pinc, Andrea Školáková, Vojtěch Hybášek, Šárka Msallamová, Petr Veřtát, Petr Ashcheulov, Martin Vondráček, Jan Duchoň, Ingrid McCarroll, Matěj Hývl, Swarnendu Banerjee, Jan Drahokoupil, Jiří Kubásek, Dalibor Vojtěch, Jaroslav Čapek
Journal: Bioactive Materials (2023)

In this study, advanced techniques such as atom probe tomography, atomic force microscopy, X-ray photoelectron spectroscopy, and electrochemical impedance spectroscopy were used to determine the corrosion mechanism of the as-ECAPed Zn-0.8Mg-0.2Sr alloy. The influence of microstructural and surface features on the corrosion mechanism was investigated. Despite its significance, the surface composition before exposure is often neglected by the scientific community. The analyses revealed the formation of thin ZnO, MgO, and MgCO3 layers on the surface of the material before exposure. These layers participated in the formation of corrosion products, leading to the predominant occurrence of hydrozincite. In addition, the layers possessed different resistance to the environment, resulting in localized corrosion attacks. The segregation of Mg on the Zn grain boundaries with lower potential compared with the Zn-matrix was revealed by atom probe tomography and atomic force microscopy. The degradation process was initiated by the activity of micro-galvanic cells, specifically Zn - Mg2Zn11/SrZn13. This process led to the activity of the crevice corrosion mechanism and subsequent attack to a depth of 250 μm. The corrosion rate of the alloy determined by the weight loss method was 0.36 mm·a-1. Based on this detailed study, the degradation mechanism of the Zn-0.8Mg-0.2Sr alloy is proposed.
Post-COVID-19 condition in patients with autoimmune rheumatic diseases: the COVID-19 Vaccination in Autoimmune Diseases (COVAD) study
Authors: Parikshit Sen, Naveen R, Arvind Nune, Jessica Day, Mrudula Joshi, Vikas Agarwal, Rohit Aggarwal, Latika Gupta
Journal: The Lancet Rheumatology (2023)
Health Status and Clinical Outcomes in Older Adults With Chronic Coronary Disease
Authors: Dan D. Nguyen, John A. Spertus, Karen P. Alexander, Jonathan D. Newman, John A. Dodson, Philip G. Jones, Susanna R. Stevens, Sean M. O’Brien, Reto Gamma, Gian P. Perna, Pallav Garg, João V. Vitola, Benjamin J.W. Chow, Andras Vertes, Harvey D. White, Paola E.P. Smanio, Roxy Senior, Claes Held, Jianghao Li, William E. Boden, Daniel B. Mark, Harmony R. Reynolds, Sripal Bangalore, Paul S. Chan, Gregg W. Stone, Suzanne V. Arnold, David J. Maron, Judith S. Hochman
Journal: Journal of the American College of Cardiology (2023)
Application of machine learning in surgery research: current uses and future directions – editorial
Authors: Prakasini Satapathy, Keerti B. Pradhan, Sarvesh Rustagi, Vinay Suresh, Zahraa H. Al-Qaim, Bijaya K. Padhi, Ranjit Sah
Journal: International Journal of Surgery (2023)

Satapathy, Prakasini PhD; Pradhan, Keerti Bhusan PhD; Rustagi, Sarvesh PhD; Suresh, Vinay MBBS; Al-qaim, Zahraa Haleem MD; Padhi, Bijaya K PhD; Sah, Ranjit MD Author Information
The impact of commercial health datasets on medical research and health-care algorithms
Authors: Isabelle Rose I Alberto, Nicole Rose I Alberto, Arnab K Ghosh, Bhav Jain, Shruti Jayakumar, Nicole Martinez-Martin, Ned McCague, Dana Moukheiber, Lama Moukheiber, Mira Moukheiber, Sulaiman Moukheiber, Antonio Yaghy, Andrew Zhang, Leo Anthony Celi
Journal: The Lancet Digital Health (2023)
Comparison between minimally invasive partial nephrectomy and open partial nephrectomy for complex renal tumors: a systematic review and meta-analysis
Authors: Kun-peng Li, Si-yu Chen, Chen-yang Wang, Li Yang
Journal: International Journal of Surgery (2023)

Background: The present study aimed to conduct a pooled analysis to compare the efficacy and safety of minimally invasive partial nephrectomy (MIPN) with open partial nephrectomy (OPN) in patients with complex renal tumors (defined as PADUA or RENAL score ≥7). Methods: The present study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, Supplemental Digital Content 1, http://links.lww.com/JS9/A394. We conducted a systematic search of the PubMed, Embase, Web of Science, and Cochrane Library databases until October 2022. MIPN and OPN-controlled trials for complex renal tumors were included. The primary outcomes were perioperative results, complications, renal function, and oncologic outcomes. Results: A total of 2405 patients were included in 13 studies. MIPN outperformed OPN in terms of hospital stay [weighted mean difference (WMD) −1.84 days, 95% CI −2.35 to −1.33; P &lt;0.00001], blood loss (WMD −52.42 ml, 95% CI −71.43 to −33.41; P &lt;0.00001), transfusion rates [odds ratio (OR) 0.34, 95% CI 0.17–0.67; P =0.002], major complications (OR 0.59, 95% CI 0.40–0.86; P =0.007) and overall complications (OR 0.43, 95% CI 0.31–0.59; P &lt;0.0001), while operative time, warm ischemia time, conversion to radical nephrectomy rates, estimated glomerular decline, positive surgical margins, local recurrence, overall survival, recurrence-free survival, and cancer-specific survival were not significantly different. Conclusions: The present study demonstrated that MIPN was associated with a shorter length of hospital stay, less blood loss, and fewer complications in treating complex renal tumors. MIPN may be considered a better treatment for patients with complex tumors when technically feasible.
Purine anabolism creates therapeutic vulnerability in hepatocellular carcinoma through m6A-mediated epitranscriptomic regulation
Authors: Man Hsin Hung, Ching Wen Chang, Kathy Cheng Wang, Jittiporn Chaisaingmongkol, Mathuros Ruchirawat, Tim F. Greten, Xin Wei Wang
Journal: Hepatology (2023)

Background and Aims: Purines are building blocks for the cellular genome, and excessive purine nucleotides are seen in tumors. However, how purine metabolism is dysregulated in tumors, and impacting tumorigenesis remains elusive. Approach and Results: Transcriptomic and metabolomic analyses of purine biosynthesis and purine degradation pathways were performed in the tumor and associated nontumor liver tissues obtained from 62 patients with HCC, one of the most lethal cancers worldwide. We found that most genes in purine synthesis are upregulated, while genes in purine degradation are inhibited in HCC tumors. High purine anabolism is associated with unique somatic mutational signatures linked to patient prognosis. Mechanistically, we discover that increasing purine anabolism promotes epitranscriptomic dysregulation of DNA damage repairing (DDR) machinery through upregulating RNA N6-methyladenosine (m 6 A) modification. High purine anabolic HCC is sensitive to DDR-targeting agents but not to standard HCC treatments, correlating with the clinical outcomes in 5 independent HCC cohorts containing 724 patients. We further showed that high purine anabolism determines the sensitivity to DDR-targeting agents in 5 HCC cell lines in vitro and in vivo . Conclusions: Our results reveal a central role of purine anabolism in regulating DDR, which could be therapeutically exploited in HCC.
Birth-Based vs Fetuses-at-Risk Approaches for Assessing Neonatal Mortality Rate by Race
Authors: Bohao Wu, Sarah Taylor, Veronika Shabanova, Nicola L. Hawley
Journal: JAMA Pediatrics (2023)

This cohort study assesses 5-year race-stratified neonatal mortality and prevalence of preterm births in the US using birth-based and fetuses-at-risk approaches.
Tackling AKI
Authors: Rajashree Rana, Matthew D. Breyer
Journal: Journal of the American Society of Nephrology (2023)

Cardiovascular Metabolism, Janssen Research and Development LLC, Boston, Massachusetts Correspondence: Dr. Matthew D. Breyer, 4 Blackfan Circle, Boston MA 02115. Email: [email protected]. See related article, "Activation of Angiopoietin-Tie2 Signaling Protects the Kidney from Ischemic Injury by Modulation of Endothelial-Specific Pathways," on pages 969–987.
Context and Differentiation in Antidepressant Effects of Physical Activity in Children and Adolescents
Authors: Henning Budde, Thomas Gronwald, Davy Vancampfort
Journal: JAMA Pediatrics (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Lessons Learned From a COVID-19 Dog Screening Pilot in California K-12 Schools
Authors: Carol A. Glaser, Chloe E. Le Marchand, Kyle Rizzo, Lea Bornstein, Sharon Messenger, Carol A. Edwards, Robert Nakamura
Journal: JAMA Pediatrics (2023)

This diagnostic study describes a dog screening program used to identify COVID-19 infections among schoolchildren.
Monoclonal Antibodies for the Treatment of COVID-19—Every Day You Fight Like You’re Running Out of Time
Authors: Erin K. McCreary, Zahra Kassamali Escobar, Julie Ann Justo
Journal: JAMA Network Open (2023)

Nalini Ambrose, MS; Alpesh Amin, MD; Brian Anderson, MD; Julio Barrera-Oro, PhD; Monica Bertagnolli, MD; Francis Campion, MD; Daniel Chow, MD; Risa Danan, MS; Lauren D'Arinzo, MS; Ashley Drews, MD; Karl Erlandson, PhD; Kristin Fitzgerald, MS; Melissa Garcia, MS; Fraser W. Gaspar, PhD; Carlene Gong, MS; George Hanna, MD; Stephen Jones, MD; Bert Lopansri, MD; James Musser, MD; John O'Horo; Steven Piantadosi, MD; Bobbi Pritt, MD; Raymund R. Razonable, MD; Seth Roberts, MD; Suzanne Sandmeyer, PhD; David Stein, PhD; Farhaan Vahidy, MD; Brandon Webb, MD; Jennifer Yttri, PhD
Characteristics of Progressive Multifocal Leukoencephalopathy Associated With Sarcoidosis Without Therapeutic Immune Suppression
Authors: Caleb R. S. McEntire, Anita Fletcher, Michel Toledano, Samantha Epstein, Emily White, C. Sabrina Tan, Yang Mao-Draayer, Samantha A. Banks, Allen J. Aksamit, Jeffrey M. Gelfand, Kiran T. Thakur, Pria Anand, Irene Cortese, Shamik Bhattacharyya
Journal: JAMA Neurology (2023)

Progressive multifocal leukoencephalopathy can occur in the context of systemic sarcoidosis (S-PML) in the absence of therapeutic immune suppression and can initially be mistaken for neurosarcoidosis or other complications of sarcoidosis. Earlier recognition of S-PML could lead to more effective treatment of the disease.
Association of State-Level Tax Policy and Infant Mortality in the United States, 1996-2019
Authors: Jean A. Junior, Lois K. Lee, Eric W. Fleegler, Michael C. Monuteaux, Michelle L. Niescierenko, Amanda M. Stewart
Journal: JAMA Network Open (2023)

Infant mortality in the United States is highest among peer nations; it is also inequitable, with the highest rates among Black infants. The association between tax policy and infant mortality is not well understood.To examine the association between state-level tax policy and state-level infant mortality in the US.This state-level, population-based cross-sectional study investigated the association between tax policy and infant mortality in the US from 1996 through 2019. All US infant births and deaths were included, with data obtained from the National Center for Health Statistics. Data were analyzed from November 28, 2021, to July 9, 2022.State-level tax policy was operationalized as tax revenue per capita and tax progressivity. The Suits index was used to measure tax progressivity, with higher progressivity indicating increased tax rates for wealthier individuals.The association between tax policy and infant mortality rates was analyzed using a multivariable, negative binomial, generalized estimating equations model. Since 6 years of tax progressivity data were available (1995, 2002, 2009, 2012, 2014, and 2018), 300 state-years were included. Adjusted incidence rate ratios (aIRRs) were calculated controlling for year, state-level demographic variables, federal transfer revenue, and other revenue. Secondary analyses were conducted for racial and ethnic subgroups.There were 148 336 infant deaths in the US from 1996 through 2019, including 27 861 Hispanic infants, 1882 non-Hispanic American Indian or Alaska Native infants, 5792 non-Hispanic Asian or Pacific Islander infants, 41 560 non-Hispanic Black infants, and 68 666 non-Hispanic White infants. The overall infant mortality rate was 6.29 deaths per 1000 live births. Each $1000 increase in tax revenue per capita was associated with a 2.6% decrease in the infant mortality rate (aIRR, 0.97; 95% CI, 0.95-0.99). An increase of 0.10 in the Suits index (ie, increased tax progressivity) was associated with a 4.6% decrease in the infant mortality rate (aIRR, 0.95; 95% CI, 0.91-0.99). Increased tax progressivity was associated with decreased non-Hispanic White infant mortality (aIRR, 0.95; 95% CI, 0.91-0.99), and increased tax revenue was associated with increased non-Hispanic Black infant mortality (aIRR, 1.04; 95% CI, 1.01-1.08).In this cross-sectional study, an increase in tax revenue and the Suits index of tax progressivity were both associated with decreased infant mortality. These associations varied by race and ethnicity. Tax policy is an important, modifiable social determinant of health that may influence state-level infant mortality.
Functionalized retinoic acid lipid nanocapsules promotes a two-front attack on inflammation and lack of demyelination on neurodegenerative disorders
Authors: Rui Pedro Moura, Eva Daniela Carvalho, Cláudia Martins, Anne des Rieux, Ana Paula Pêgo, Bruno Sarmento
Journal: Journal of Controlled Release (2023)

Demyelinating disorders, with a particular focus on multiple sclerosis (MS), have a multitude of detrimental cognitive and physical effects on the patients. Current treatment options that involve substances promoting remyelination fail in the clinics due to difficulties in reaching the central nervous system (CNS). Here, the dual encapsulation of retinoic acid (RA) into lipid nanocapsules with a nominal size of 70 nm, and a low PdI of 0.1, coupled with super paramagnetic iron oxide nanoparticles (SPIONs) was accomplished, and joined by an external functionalization process with a transferrin-receptor binding peptide. This nanosystem showed a 3-fold improved internalization by endothelial cells compared to the free drug, ability to interact with oligodendrocyte progenitor cells and microglia, and improvements in the permeability through the blood-brain barrier by 5-fold. The lipid nanocapsules also induced the differentiation of oligodendrocyte progenitor cells into more mature, myelin producing oligodendrocytes, as evaluated by high-throughput image screening, by 3-5-fold. Furthermore, the ability to tame the inflammatory response was verified in lipopolysaccharide-stimulated microglia, suppressing the production of pro-inflammatory cytokines by 50-70%. Overall, the results show that this nanosystem can act in both the inflammatory microenvironment present at the CNS of affected patients, but also stimulate the differentiation of new oligodendrocytes, paving the way for a promising platform in the therapy of MS.
The Emerging Role of Circulating Tumor DNA in Non-Colorectal Gastrointestinal Cancers
Authors: Michael S. Lee, Ahmed O. Kaseb, Shubham Pant
Journal: Clinical Cancer Research (2023)

Assays to detect circulating tumor DNA (ctDNA) have multiple clinically important applications in management of multiple types of gastrointestinal cancers. Different methodologies of ctDNA detection have varying sensitivities and potential applications in different contexts. For patients with localized cancers treated for curative intent, ctDNA detection is associated with prognosis in multiple cancer types, and persistent detection of ctDNA after surgical resection is highly concerning for minimal residual disease (MRD) and forebodes impending radiographic and clinical recurrence. CtDNA assays for comprehensive genomic profiling enable genotyping of cancers in the absence of tumor tissue data, and longitudinal testing can also characterize clonal evolution and emergence of putative resistance mechanisms upon treatment with targeted agents. These applications have proven instructive in patients with HER2-amplified gastric and esophageal cancers and in patients with FGFR2 fusion cholangiocarcinomas. In this review, we summarize data supporting the role of ctDNA as a novel predictive and prognostic biomarker and potential impacts on current management of patients with pancreatic, gastroesophageal, and hepatobiliary cancers.
Artificial Intelligence–Enabled Analysis of Statin-Related Topics and Sentiments on Social Media
Authors: Sulaiman Somani, Marieke Meija van Buchem, Ashish Sarraju, Tina Hernandez-Boussard, Fatima Rodriguez
Journal: JAMA Network Open (2023)

Despite compelling evidence that statins are safe, are generally well tolerated, and reduce cardiovascular events, statins are underused even in patients with the highest risk. Social media may provide contemporary insights into public perceptions about statins.
A Brief History of the 3-Day Hospital Stay Rule
Authors: Vincent Mor
Journal: JAMA Internal Medicine (2023)

Agne Ulyte, MD, PhD; R. J. Waken, PhD; Arnold M. Epstein, MD, MA; E. John Orav, PhD; Michael L. Barnett, MD, MS; Karen E. Joynt Maddox, MD, MPH; David C. Grabowski, PhD
Patients and Their Physician’s Perspectives About Oral Anticoagulation in Patients With Atrial Fibrillation Not Receiving an Anticoagulant
Authors: Christopher P. Cannon, Joseph M. Kim, Jane J. Lee, Julie Sutherland, Ravinder Bachireddy, C. Michael Valentine, Steven Hearne, April Trebnick, Sara Jaffer, Sudarshana Datta, Emily Semmel, Fran Thorpe, Gheorghe Doros, Matthew A. Cavender, Matthew R. Reynolds, Clifford L. Ehrlich, Sherrie Ehrlich, Tina Ford, Cindy Baumann, Nasser Smiley, Shirley Schmidt, Diane Philip, Erica Daniels, Mark Huth, Jean Anne Eisenhaure, Laura Mancia, Paul Phillips, Kate Maloney, Linda Selker, Jennifer Zelik, Harvey Chen, Vicki Beckner, Mario Pascual, Jeffrey Kaplan, Monica Calvo, Zakir Sahul, Carol Carulli, Shelton W. Thomas, Laura Puckett, Joshua Larned, Harmony Bourque, Steve Compton, Lori Heaney, Jeffrey Fenster, Cynthia Robinson, Francisco Aguilar, Claudia Eaton, Jeff Taylor, Judith McCabe, Anthony B. Ochoa, Deborah Douglas, Eteri Byazrova, Shamela Barnett, Jason Talavera, Stephanie Abbott, Mickella Knapp
Journal: JAMA Network Open (2023)

The underuse of oral anticoagulation in patients with nonvalvular atrial fibrillation (AF) is a major issue that is not well understood.