tbuckley/cabot-search huggingface dataset:
CD69 expression and tumour necrosis factor-α immunoreactivity in the inflammatory cell infiltrate of halo naevi
Authors: J. FERNÁNDEZ-HERRERA, E. FERNÁNDKZ-RUIZ, M. LÓPEZ-CABRERA, A. GARCÍA-DÍEZ, F. SÁNCHEZ-MADRID, R. GONZÁLEZ-AMARO
Journal: British Journal of Dermatology (1996)

It has been suggested that the involution of the pigmented lesions of halo naevus (HN) is mediated by an immune response, with the involvement of specific cytotoxic T lymphocytes. To explore further the pathogenesis of HN. skin biopsies from six patients with this condition were obtained and the characteristics of the infiltrating inflammatory ceils were studied by immunostaining techniques. We found that the cell infiltrate of HN is mainly composed by CD8+ T lymphocytes that express the activation molecule CD69. Tumour necrosis factor‐α (TNF‐α) immunoreactivity was detected on the inflammatory cells, a finding that suggests that the infiltrating T cells of HN are actively synthesizing this cytokine. Our results indicate that the infiltrating cells of HN predominantly have an activated cytotoxic phenotype, and suggest that these cells are indeed involved in the regression of the naevomelanocytic naevus of HN.
Cell-matrix interactions of normal and transformed human keratinocytes<i>in vitro</i>are modulated by the synthetic phospholipid analogue hexadecylphosphocholine
Authors: M. SCHÖN, M.P. SCHÖN, C.C. GEILEN, M. HOFFMANN, N. HAKYI, C.E. ORFANOS, W. REUTTER
Journal: British Journal of Dermatology (1996)

We have investigated the effect of the synthetic phospholipid analogue, hexadecylphosphocholine (HePC), a member of a new class of membrane‐affecting antiproliferative drugs, on adhesion to extracellular matrix components, reorganization of three‐dimensional collagen lattices, and proliferative activity of human keratinocyte populations in vitro. Six transformed keratinocyte lines were compared with their normal counterparts from interfollicular epidermis. Adhesion to collagen types I and IV, laminin, and fibronectin was weakest in normal keratinocytes (binding of 3–10% of the cells), followed by HaCaT and HaCaT‐II/3 (25‐30% binding), and the squamous carcinoma lines and SV‐40 transformed keratinocytes (35‐50% binding). Treatment with non‐toxic doses of 10–20 μmol/1 HePC led to a clear inhibition of the adhesive interactions by 50–75% in all populations. The impaired adhesion capacity was paralleled by a clear decrease of the ability of all keratinocyte populations to contract three‐dimensional collagen lattices, an experimental mental model system for the reorganization of extracellular matrices. Histological examination revealed that these effects were due to a reduced cell number in the collagen lattices, a finding underscored by significant inhibition of proliferative activity of all keratinocyte populations by HePC. Furthermore, HePC led to marked changes of cellular morphology in the contracted gels. FACS analysis revealed that the impaired interaction with components of the extracellular matrix was not due to a specific downregulation of β1‐integrins, the major cell‐surface receptors for the respective matrix proteins. In conclusion, our results provide new insights into the potential action of HePC in a variety of skin disorders. Decreased proliferative activity and changes of cellular morphology, combined with impaired interactions with extracellular matrix proteins and a consecutive loss of matrix organization capacity, may cause suppression of different hyperproliferative skin diseases.
Ectopic cutaneous schistosomiasis: extragenital involvementwith progressive upward spread
Authors: A.M. FARRELL, D. WOODROW, A.D.B. BRYCESON, C.B. BUNKER, J.J. CREAM
Journal: British Journal of Dermatology (1996)

The ectopic deposition of ova of Schistosoma haematobium within the dermis is very rare, even in countries where infection with this trematode is widespread. When it does occur, it usually affects the genital area. We report a patient who developed ectopic genital and extragenital cutaneous involvement 4 months after swimming in Lake Malawi. The lesions appeared sequentially and spread from the genitalia in a caudocephalic manner. Doppler imaging of the pelvic veins did not reveal any anomalous venous drainage to account for the distribution of these lesions.
Painful piezogenic pedal papules: response to local etectro-acupuncture
Authors: S.L. WOODROW, G. BRERETON-SMITH, S. HANDFIETD-JONES
Journal: British Journal of Dermatology (1997)

We report the case of a woman who had pain in both heels which was exacerbated by long periods of exercise. On examination, There were small flesh-coloured papules which appeared over the medial and lateral aspects of the heels only on weight bearing. Coincidentally. she was noted to have larger flesh-coloured papules over the anterior surface of the shins. The diagnoses of painful piezogenic pedal papules and bilateral tibialis anterior muscle herniation, respectively, were made. After many attempts to control the pain, a course of electro-acupuncture was commenced. A good subjective clinical response was achieved which has been maintained by fortnightly treatments. We discuss the prevalence, pathogenesis and treatment of painful piezogenic pedal papules. We believe that our patient is the first to have 'herniations' at both heel and shin sites and the first to have successful sustained pain relief for painful piezogenic pedal papules
The expression of integrin α2β1 and attachment to type I collagen of melanoma cells are preferentially induced by tumour promoter, TPA (12-<i>O</i>-tetradecanoyl phorbol-13-acetate)
Authors: H. EGUCHI, T. HORIKOSHI
Journal: British Journal of Dermatology (1996)

The adhesion of melanoma cells to the extracellular matrix (ECM) protein is likely to be essential in their invasive metastatic processes. Treatment with 12‐O‐tetradecanoyl phorbol‐13‐acetate (TPA), a potent protein kinase C (PKC) activator, preferentially induced the expression of α2β1 integrin, the receptor for collagen/laminin. The number of cells attached to type I collagen, but not laminin, was increased by treatment with TPA. Prior exposure to PKC inhibitors such as H‐7 (20 μmol/1) and calphostin C (50μmol/1) had no effect on TPA‐induced α2β1 integrin expression and cell attachment to type I collagen, whereas prior exposure to the calmodulin antagonist W‐7(50 μmol/1) inhibited these TPA‐induced events. The augmented adhesion was also inhibited by anti‐α2 antibody. These data suggest that the increased attachment of melanoma cells to type I collagen appears to be mediated by the preferential augmentation of integrin α2β1, and the activation of calmodulin kinase, but not via the activation of PKC. Analysis of the expression of integrins and of cell attachment to ECMs is important in elucidating the mechanisms involved in the progression and metastasis of malignant melanoma.
Michelin tyre syndrome: a congenital disorder of elastic fibre formation?
Authors: M. SATO, O. ISHIKAWA, Y. MIYACHI, T. AOKI, T. TOMOMASA, K. NAGASHIMA
Journal: British Journal of Dermatology (1997)

We describe a 15-month-old girl with Michelin tyre syndrome. She had hirsuties and marked skin folds. Histological examination showed fragmented elastic fibres in addition to smooth muscle hamartoma. On electron microscopy, decreased deposition of elastin was observed. We speculate that elastic fibre abnormafities may account for the characteristic skin changes in the Michelin tyre syndrome.
Coexistence of palmoplantar lichen planus and lupus erythematosus with response to treatment using acitretin
Authors: E. M. G. J. DE JONG, P. C. M. VAN DE KERKHOF
Journal: British Journal of Dermatology (1996)

Lichen planus and lupus erythematosus may occur as an overlap syndrome. Here we report the clinical characteristics of a 49-year-old man with palmoplantar lichen planus and lupus erythematosus. He showed a remarkable clinical response to treatment with acitretin, which resulted in prolonged remission of the disorder.
The cost of atopic eczema
Authors: R.M. HERD, M.J. TIDMAN, R.J. PRESCOTT, J.A.A. HUNTER
Journal: British Journal of Dermatology (1996)

Summary Atopic eczema affects 2.3% of the U.K. population. We have carried out a community study in a semi-rural area to assess its economic impact. One hundred and fifty-five patients with atopic eczema were identified and expenditure was assessed over a 2-month period. The mean personal cost to the patient was £25.90, while the mean cost to the health service was £16.20. There were 58 lost working days and 17 lost school days. A cohort of 10 severely affected patients attending the Royal Infirmary of Edinburgh were studied; each patient spent, on average, £325 in 2 months, and lead to a mean health service expenditure per patient of £415, in 2 months. If these results were extrapolated to the U.K. population, the annual personal cost to patients with atopic eczema would be £297m, the cost to the health service would be £125m, and the annual cost to society of lost working days would be £43m, making the total expenditure on atopic eczema £465m.
Disseminated varioliform pustular eruption due to <i>Mycobacterium avium intracllulare</i> in an HIV-infected patient
Authors: H. BACHELEZ, G. DUCLOY, L. PINQUIER., M. ROUVEAU, J. SIBILLA, L. DUBERTRET
Journal: British Journal of Dermatology (1996)

Summary Severe disseminated infection due to Mycobacterium avlum intracellulare, with unusual cutaneous features, is reported in a patient with acquired immunodeficiency syndrome (AIDS). The eruption appeared as disseminated pustule lesions which showed necrotic features and which led to varioliform scarring. Bacterial culture from the skin, blood, and bone marrow, and ultimately from the hronchoalveolar fluid and sputum, was positive for M. avium intracellulare. The patient was successfully treated using a multiple agent anti-mycohacterial regimen including clarithromycin, which appeared to be the most effective drug. This resulted in resolution of the cutaneous and general symptoms. Our patient illustrates the wide spectrum of skin presentations that may he seen with mycohacterial infections in subjects infected with the human immunodeficiency virus (HIV). Clarithromycin is an important agent for the treatment of these severe infections.
A CASE OF LEUCOCYTHAEMIA CUTIS.*
Authors: H. BATTY SHAW, D. LOUGHLIN
Journal: British Journal of Dermatology (1917)

Journal Article A CASE OF LEUCOCYTHÆMIA CUTIS. Get access H. BATTY SHAW, M.D., H. BATTY SHAW, M.D. Search for other works by this author on: Oxford Academic Google Scholar D. LOUGHLIN D. LOUGHLIN Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 29, Issue 1, 1 January 1917, Pages 36–42, https://doi.org/10.1111/j.1365-2133.1917.tb09649.x Published: 01 January 1917
Re-epithelialization of normal human excisional wounds is associated with a switch from αvβ5 to αvβ6 integrins
Authors: R.A.F. CLARK, G.S. ASHCROFT, M.-J. SPENCER, H. LARJAVA, M.W.J. FERGUSON
Journal: British Journal of Dermatology (1996)

Summary During cutaneous wound repair, keratinocytes move laterally across the wound surface. For this lateral movement epidermal cells must disassemble their tenacious connections to the basement membrane and their neighbouring cells, and express surface receptors that permit translocation over the wound surface extracellular matrix. If the basement membrane is disrupted, the epidermis migrates over a provisional matrix that contains fibrinogen, fibronectin, vitronectin and tenascin. Although α5β1 integrin, a fibronectin receptor, is expressed by human epidermis during reepithelialization of excisional and incisional wounds, the spatial and temporal patterns of vitronectin, tenascin, and other fibronectin receptors are less clear. Other potential receptors include αvβ5 for vitronectin and αvβ6 for fibronectin and tenascin. To study provisional matrix integrin expression during human wound healing, full-thickness 4-mm punch biopsies were performed on the inner surface of the upper arm in adult volunteers. At 3, 7 and 14 days after injury wound sites were excised, bisected, quick frozen in liquid nitrogen, and examined for the expression of α5, β1, αv, β5 and β6. At 3 days, α5β1 and αvβ5, but not αvβ6, appeared around the basal and suprabasalar cells of the migrating epidermis. At 7 days, α5β1, αvβ5, and αvβ6 appeared around the perimeter of the basal cells of the migrating epidermis. By 14 days, when re-epithelialization was complete, all basal and suprabasalar cells overlying the wound expressed α5β1 and αvβ6, but not αvβ5. Thus, αv appeared to switch its heterodimeric association from β5 to β6 subunit during re-epithelialization.
Hypopigmented sarcoidosis in the negro
Authors: ROGER CLAYTON, AODAN BREATHNACH, BARRY MARTIN, MICHAEL FEIWEL
Journal: British Journal of Dermatology (2006)

The dermatological aspects of eight negro patients with hypopigmented sarcoid lesions are described. Light microscope histochemical studies in two patients did not reveal the mechanism of the hypopigmentation. However, electronmicroscopy of lesions in two patients showed melanocytes undergoing changes resembling those observed in other acquired hypopigmentary conditions. It is suggested that in these disorders, melanocytes react morphologically in a similar non-specific manner, whatever the prime pathological process.
Evaluation of skin damage. I
Authors: F.A.J. THIELE, K.E. MALTEN
Journal: British Journal of Dermatology (2006)

The impedance of human skin was measured at a frequency of 25 Hz and 0.032 mA before, during and after exposing 6 cm2 skin for 60–240 min to 10 or 12 ml of alkali (NaOH and sodium phosphate) and sodium chloride solutions, adjusted to different pHs. From the impedance and phase angle values, measured at intervals of 10–60 min between different pairs of skin sites, the changes in the single transition resistances of these skin sites were calculated. Sodium hydroxide (NaOH) solution at pH 12.0, within 10 to 15 min, abolished skin resistance completely; a solution of sodium phosphate, adjusted to the same pH, affected skin resistance similarly, but only after 60 minutes. The order of severity in skin effects of solutions of other alkaline substances, adjusted to different pHs was determined.
Hypersensitive and insensitive extremities*
Authors: SAMUEL L.MOSCHELLA
Journal: British Journal of Dermatology (2006)

The importance of physically intact hands and feet is taken for granted and consequently not appreciated until they are functionally impaired by vascular or neural injury or disease. The pathogenesis and clinical manifestations of cutaneous lesions complicating hypersensitive and insensitive limbs are described. The current therapeutic approaches and measures for these conditions are presented. Protection and prophylaxis against precipitating trauma for neurologically impaired parts are emphasized.
Intercellular antibodies in blood and epidermis
Authors: MICHAEL J. FELLNER, KIMIE FUKUYAMA, ALAN MOSHELL, MARIA V. KLAUS
Journal: British Journal of Dermatology (2006)

Antibodies directed against intercellular epithelial structures (ICE) have been important in the diagnosis of pemphigus vulgaris. Our study of thirty-seven patients with maculopapular eruptions following therapy with penicillins, clearly indicate that antibodies morphologically indistinguishable from those found by standard techniques in pemphigus vulgaris are also found here. Indirect staining by fluorescence and horse-radish peroxidase indicated localization against ICE identical to that seen in pemphigus, in about half the patients. Direct staining of skin from two penicillin-allergic patients revealed similar staining in the familiar pattern, which closely resembles the network of lines in giraffe skin. Detection of circulating antibody directed against a component of epithelium introduces new insight into the pathophysiology of maculopapular penicillin eruptions, although further work is required to show what the exact relationship is to pemphigus vulgaris, the potentially fatal skin disease.
Histocompatibility antigens in granuloma annulare
Authors: R. FRIEDMAN-BIRNBAUM, S. HAIM, O. GIDEONE, A. BARZILAI
Journal: British Journal of Dermatology (2006)

Thirteen patients with localized granuloma annulare and 19 with the generalized form of the disease were typed for HLA antigens. The control group consisted of 70 matched apparently healthy subjects. No significant difference in the frequencies of the 26 tested antigens was revealed between patients with localized granuloma annulare and controls. Patients with the generalized form of the disease showed a highly significant increase in the frequency of HLA-BW35 as compared with both controls and patients with the localized form of the disorder (P=0 001 and 0.01 respectively). The results seem suggestive of a possible different pathogenesis of the two forms of the disease.
Human malignant melanoma
Authors: J.A.A. HUNTER, W.D. PATERSON, D.J. FAIRLEY
Journal: British Journal of Dermatology (2006)

An ultrastructural dopa reaction, with glutaraldehyde‐formaldehyde prefixation, was carried out on ten specimens of malignant melanoma showing a wide variation in melanosomal morphology. All tumours, but only a minority of tumour cells, contained reaction product. In all tumours the reaction product was distributed similarly in the Golgi apparatus and Golgi associated endoplasmic reticulum (GERL). However, differences were noted in its deposition in melanosomes. Whereas vacuolar and lamellar profiles sometimes contained reaction product, it was not seen in normal, granular and abortive melanosomes. Tumour cells without melanosomes were also seen to contain reaction product.
Naevus superficialis lipomatosus
Authors: EDWARD WILSON JONES, RONALD MARKS, D. PONGSEHIRUN
Journal: British Journal of Dermatology (2006)

Naevus superficialis lipomatosus (NSL) is a rare malformation consisting of multiple or solitary papules usually occurring on the lower trunk or gluteal regions. In this study the clinical features of twenty new cases are described with a detailed account of the histopathology. Notable were the marked variability in the amount of ectopic fat found in the lesions, and the presence of associated abnormalities of the connective tissue, the vessels, and the skin appendages. In early lesions, mononuclear cells differentiating into lipoblasts could be identified around proliferating capillaries. Two clinical types were distinguished. First, the classical type (7 cases) consisting of multiple lesions occurring in a zonal distribution, and secondly the solitary papule or nodule (13 cases). The latter type can be difficult to distinguish from a skin tag with fatty herniation.
Tissue nickel levels and nickel dermatitis*
Authors: S.A. KATZ, H.J.M. BOWEN, J.S. COMAISH, M.H. SAMITZ
Journal: British Journal of Dermatology (2006)

The determination of nickel by instrumental neutron activation analysis is presented. The 58Ni (n, p) 58Co reaction and high‐resolution gamma spectroscopy were employed in these measurements. The nickel content of human hair was found to be more dependent upon the sex of the donor than upon other parameters. Mean values for males (1·01±0·23 ppm) and females (4·21±0·54 ppm) agreed with values for the nickel content of hair obtained by other methods in most cases. Nickel sensitivity was not reflected in the nickel contents of hair in the female.
Neutron activation analysis of trace elements in skin
Authors: MOHAMED M. MOLOKHIA, BENJAMIN PORTNOY
Journal: British Journal of Dermatology (2006)

Copper and zinc levels were estimated in serum and skin of nineteen vitiligo patients as well as in pigmented moles, seborrhoeic warts and normal skin. In seborrhoeic warts, high zinc levels were associated with excessive melanization and an abundance of ATPase+ve dendritic cells. Zinc levels were also significantly increased in pigmented moles compared with those in normal surrounding skin. In vitiligo, there was a significant reduction in serum zinc while copper levels were increased in the hyperpigmented zone surrounding the lesion. The results of copper analysis in vitiligo neither support a deficiency role for copper nor justify its use in the treatment of that disease.
Microvascular response to local application of dequalinium chloride
Authors: HÅKAN MOBACKEN, MIKAEL ROMANUS
Journal: British Journal of Dermatology (2006)

Dequalinium chloride is a topical antiseptic, whose use may be attended by skin necrosis. Since microcirculatory changes are an early and distinct manifestation of tissue injury, the tissue damaging effect of dequalinium chloride on the microcirculation was examined. The immediate vascular reactions were studied by vital microscopy of the hamster cheek pouch and the late effects were visualized by microangiography of the rabbit ear. An aqueous solution of dequalinium chloride in concentrations well below those used in clinical practice induced severe microcirculatory disturbances.
Generalized buUous and haemorrhagic lichen sclerosus et atrophicus*
Authors: ADRIANO DI SILVERIO, FERDINANDO SERRI
Journal: British Journal of Dermatology (2006)

An unusual case of lichen sclerosus et atrophicus is described, in which lesions were bullous and haemorrhagic and extended over almost the entire stirface of the skin. A marked improvement followed treatment with ACTH.
Half-and-half cells in lichen planus
Authors: R.A.J. EADY, T. COWEN
Journal: British Journal of Dermatology (2006)

In the course of a study of wound healing in four patients with lichen planus, we found transformed keratinocytes with a hitherto undescribed ultrastructure in both wounded and undisturbed papules. We have called these epidermal cells half-and-half cells because they showed changes on the one hand of increased synthetic activity and, on the other hand, of fibrillar transformation closely resembling that seen in fully developed colloid bodies. We suggest that these half-and-half cells may provide a useful clue to the early changes occurring in colloid body formation.
THERAPEUTICS V
Authors: D. Burrows, R. G. Shanks, C. J. Stevenson
Journal: British Journal of Dermatology (1969)

Journal Article THERAPEUTICS V Get access D. Burrows, D. Burrows Royal Vietoria Hospital Belfast Search for other works by this author on: Oxford Academic Google Scholar R. G. Shanks, R. G. Shanks Department of Therapeuties Queen's University, Belfast Search for other works by this author on: Oxford Academic Google Scholar C. J. Stevenson C. J. Stevenson Royal Victoria Intirmary, Neweastle‐upon‐Tyne Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 2, 1 February 1969, Pages 166–170, https://doi.org/10.1111/j.1365-2133.1969.tb15999.x Published: 01 February 1969
ROYAL SOCIETY OF MEDICINE..
Authors: G. B. Dowling
Journal: British Journal of Dermatology (1953)

Journal Article ROYAL SOCIETY OF MEDICINE.: SECTION OF DERMATOLOGY. Get access G. B. Dowling G. B. Dowling Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 65, Issue 9, 1 September 1953, Pages 314–325, https://doi.org/10.1111/j.1365-2133.1953.tb13757.x Published: 01 September 1953
VEHICLE ASSESSMENT—METHODOLOGY AND RESULTS
Authors: GEORGE A. CHRISTIE, MIRIAM MOORE-ROBINSON
Journal: British Journal of Dermatology (1970)

Journal Article VEHICLE ASSESSMENT—METHODOLOGY AND RESULTS Get access GEORGE A. CHRISTIE, GEORGE A. CHRISTIE Department of Clinical Research, Syntex Pharmaceuticlsa Limited, Maidenhead Search for other works by this author on: Oxford Academic Google Scholar MIRIAM MOORE‐ROBINSON MIRIAM MOORE‐ROBINSON Department of Clinical Research, Syntex Pharmaceuticlsa Limited, Maidenhead Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 82, Issue s6, 1 June 1970, Page 93, https://doi.org/10.1111/j.1365-2133.1970.tb08012.x Published: 01 June 1970