tbuckley/cabot-search huggingface dataset:
Glycoconjugate With &lt;italic&gt;Ulex europaeus&lt;/italic&gt; Agglutinin-I-Binding Sites in Normal Mucosa, Adenoma, and Carcinoma of the Human Large Bowel&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Suguru Yonezawa, Takao Nakamura, Sadao Tanaka, Eiichi Sato
Journal: JNCI Journal of the National Cancer Institute (1982)

Cancerous lesions and nonneoplastic mucosa of surgically extirpated specimens from 94 patients with colorectal carcinoma (of the right colon, 31 patients; of the left colon, 29 patients; and of the rectum, 34 patients) and endoscopically polypectomized specimens from 18 patients with rectal adenoma were examined with fluorescein isothiocyanate-conjugated or horse-radish peroxidase-conjugated Ulex europaeus agglutinin-I (UEA-I) specific to a certain terminal α-l-fucosyl residue in glycoconjugates. Of the 31 patients with right colon cancers, 22 showed positive UEA-I binding in the neoplastic cell apexes, apical luminal borders, and luminal secretions. The adjacent nonneoplastic mucosa of all 31 patients, however, demonstrated positive UEA-I binding in the goblet cell mucus. UEA-I binding was positive for 23 of the 29 left colon cancers and for 28 of the 34 rectal cancers, although UEA-I binding was not revealed in the adjacent nonneoplastic mucosa for most of the cases. Of the 18 rectal adenomas, 12 specimens showed positive UEA-I binding in the apical secretions of their adenoma cells. Marked regional differences of UEA-I binding in the nonneoplastic mucosae indicated that the constituents of glycoprotein with UEA-I binding sites in goblet cell mucus differed significantly between the human right and left large bowels. Positive UEA-I binding in many rectal cancerous and adenomatous lesions suggested that a neoplastic glycoprotein with α-l-fucosyl residue was produced or that the terminal carbohydrate structure of glycoprotein present in the nonneoplastic mucosa was altered to bind easily with UEA-I after the neoplastic transformation had occurred. A possible relation of this UEA-I binding to blood group H(O) substance is discussed.
Highlights from Recent Cancer Literature
Journal: Cancer Research (2018)

CTCF Is Not AloneThe CTCF DNA-binding protein insulates genes in topologically associated domains (TAD).Through genome-wide chromatin interaction analyses, Weintraub and colleagues (1) show that the ubiquitously expressed zinc finger transcription factor YY1 binds to active enhancers and promoterproximal elements in functional loops.Similar to CTCF, YYI is capable of dimerization and looping DNA.Perturbation of YY1 binding sites or degradation of YY1 disrupted enhancer-promoter interactions, looping, and gene expression.Expert Commentary: This and a prior report by Beagan and colleagues (2) identified YY1 as a mediator of loop interactions between developmentally regulated enhancers and promoters.YYI-mediated interactions also were nested within TADs, arising during transition from pluripotent to neural progenitor cells, suggesting reorganization of these smaller loops during development.(Image courtesy of Wikimedia Commons.)
Treatment of a Professional Degree and License on Divorce
Authors: Wayne G. Hoppe
Journal: JAMA (1983)

COURTS have, in recent years, wrestled with difficult issues relating to the valuation and distribution of an advanced educational degree and professional license as a marital asset in a divorce property settlement. No clear trend has emerged from the courts' treatment of this problem. The court in<i>Wisner v Wisner</i>, 631 P2d 115, 123 (Ariz App 1981), referred to "the rather common situation in which one spouse puts the other through professional school followed closely by a dissolution [of marriage] upon the completion of schooling... [as]... perhaps the clearest picture of the injustice which may evolve." Despite such a possibility, the majority of courts ruling on the question have held that educational attainments such as a medical degree or license are not property subject to division in the event of divorce. As one explained: An educational degree... is simply not encompassed even by the broad views of the concept of
Effect of Castration and 17&lt;italic&gt;β&lt;/italic&gt;-Estradiol Pulse on Cell Proliferation in the Uterus and the MXT Mouse Mammary Tumor&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Robert J. Paridaens
 5, Andre J. Danguy, Guy Leclercq, Robert Kiss, Jean-Claude Heuson
Journal: JNCI Journal of the National Cancer Institute (1985)

The effects of a single 17β-estradiol (E2) injection on cell proliferation were studied in 3 groups of 30 mice transplanted with the MXT ovary-dependent mammary tumor. In group A, all animals were castrated prior to tumor implantation; groups B and C had intact ovaries at the time of transplantation, but group B was left intact throughout the experiment, while group C underwent castration 4 weeks later. On day 40 in groups B and C and on day 80 in group A, in which tumor development was significantly delayed, the same procedure for testing the effects of E2 was applied: Ten controls received 0.1 ml saline ip and were killed on the next day; 4 lots of 5 mice received 0.25 μg E2 ip and were killed one by one at 12-hour intervals. Exactly 1 hour prior to sacrifice, each animal received 25 μCi [methyl-3H]thymidine ip. Histologic sections of tumors and uteri were processed for autoradiography, and nuclear thymidine (dThd) labeling indices (LI) were determined. All tumors of group A grafted under unfavorable hormonal conditions were poorly differentiated, and E2 injection induced no appreciable changes in their dThd LI. Tumors B and C were well-differentiated adenocarcinomas, in which E2 induced significant modifications of cell proliferation. In group B, complex changes in dThd LI occurred in tumors as well as in uteri, probably due to interferences with the ovarian hormonal production. In group C1 E2 produced a marked rise in dThd LI in tumors, lasting from the 12th to the 36th hour after its injection. Stimulation was maximum at the 24th hour, representing a 2.8-fold increase over mean basal dThd LI. It is concluded that the presence of an intact ovarian function at the time of transplantation is critical for maintaining the properties of hormone dependence in MXT tumors. In mice castrated after tumor implantation, a single E2 injection induces a marked and partially synchronous proliferation of neoplastic cells. The hypothesis that such hormonal manipulation might amplify the killing effect of cell cycle- or phase-specific cytotoxic drugs could be adequately tested with this model.
Dual Defect in Metabolism of Very-Low-Density Lipoprotein Triglycerides
Authors: Y. Antero Kesaniemi
Journal: JAMA (1984)

Transport of very-low-density lipoprotein (VLDL) triglycerides (TGs) were studied in eight patients with type 5 hyperlipoproteinemia (HLP). Results were compared to those from patients with type 4 HLP. Type 4 patients had either overproduction of VLDL TGs (nine patients) or defective clearance of VLDL TGs (eight patients). Patients with type 5 HLP were found to have increased production rates of VLDL TG, but also reduced fractional catabolic rates of VLDL TGs. Synthesis rates of VLDL TGs in type 5 were similar to those in type 4 patients with overproduction of VLDL TGs. The mean fractional catabolic rate in patients with type 5 HLP also were similar to those of type 4 patients with defective clearance. This study demonstrates that in most patients with type 5 HLP there is a dual defect in TG metabolism—overproduction of VLDL TGs and a clearance defect for TG-rich lipoproteins. (<i>JAMA</i>1984;251:2542-2547)
Highlights from Recent Cancer Literature
Journal: Cancer Research (2017)

Blocking the "Don't Eat Me" Signal in Pediatric Brain Tumors Gholamin and colleagues treated malignant pediatric brain tumor models with a humanized anti-CD47 antibody (Hu59-G4).In primary and metastatic high-risk medulloblastoma, Hu5F9-G4 inhibited growth in vivo, including CD15-positive putative medulloblastoma stem cells.Because children with group 3 medulloblastoma die primarly from leptomeningeal metastases, the authors treated the leptomeninges with continuous intraventricular infusion of Hu5F9-G4, observing robust activity.Neither viability nor proliferation rate of normal neural stem cells was affected.They also evaluated Hu5F9-G4 in pediatric ATRT, PNET, pediatric GBM, and DIPG, again demonstrating robust activity against each.Finally, they evaluated Hu5F9-G4 in an immunocompetent model of mouse high-grade glioma, confirming both efficacy and minimal toxicity against the developing nervous system.These results suggest anti-CD47 therapy as a promising strategy across a variety of pediatric brain tumors.(Image courtesy of Wikimedia Commons.)
Intravenous Injection of Crude Marihuana
Authors: A. B. King
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Four cases of an acute illness following the intravenous injection of crude marihuana have been reported.<sup>1-3</sup>Recently we had the opportunity to study three additional cases sufficiently different from those previously reported to warrant this presentation. An attempt was made to determine whether the thrombocytopenia seen with this illness is due to platelet consumption from intravascular coagulation as suggested by Henderson and Pugsley.<sup>1</sup> All cases were in young healthy white male drug users who used the same marihuana on the same occasion. A few months prior to this illness, one patient had injected marihuana intravenously without collapsing. In these papatients the hypotension was responsive to therapy and consequently little renal insufficiency followed. Glucosuria was noted in two patients who were not treated with intravenously administered dextrose solutions. Hepatomegaly was found in one case but there was no elevation of the total bilirubin level. Blood cultures
Arthritis and the Rheumatic Diseases
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Failure of Cytarabine in Varicella-Zoster Infections
Authors: Charles M. Davis
Journal: JAMA (1973)

In an effort to confirm the reported efficacy of cytarabine for the treatment of varicella-zoster (VZ), a double-blind study comparing cytarabine—150 mg/sq m of body surface for 36 hours—to dextrose in water was performed in cancer and immunosuppressed patients. One of the five cytarabine-treated patients and two of the three placebo-treated patients developed disseminated lesions. The acute phase and the time necessary for healing were the same in both groups. Until the natural course of VZ is documented in a large series of cancer patients, the benefit of medications such as cytarabine will remain in doubt.
Surgical Anatomy. A Treatise on Human Anatomy in its Application to the Practice of Medicine and Surgery.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serum lysyl oxidase activity in chronic liver disease in comparison with serum levels of prolyl hydroxylase and laminin
Authors: Yoshikazu Murawaki, Yuka Kusakabe, Chisato Hirayama
Journal: Hepatology (1991)

Lysyl oxidase was partially purified from serum by a diethylaminoethyl batch procedure in the presence of 6 mom/L urea and dialyzed against 3 mol/L KSCN. Using this method, we determined serum lysyl oxidase activity in 52 patients with liver disease and in 14 healthy controls, and we examined usefulness of serum lysyl oxidase in assessing liver fibrogenesis. For this purpose, serum lyayl oxidase activity in chronic liver disease was compared with serum levels of prolyl hydroxylase and laminin P1. As compared with controls, serum lysyl oxidase activity increased 1.6-fold in chronic persistent hepatitis, 4.4-fold in chronic active hepatitis and 11.8-fold in cirrhosis, indicating an increase in concert with the development of liver fibrosis. In hepatocellular carcinoma, the serum activity, although signiscantly increased, was lower than that in cirrhosis. Serum prolyl hydroxylase was significantly increased in chronic active hepatitis, in liver cirrhosis and in hepatocellular carcinoma Serum laminin P1 was significantly increased in chronic active hepatitis, in cirrhosis and in hepatocellular carcinoma Serum lysyl oxidase activity did not correlate significantly with serum levels of prolyl hydroxylase and laminin P1 in any subject or in any subgroup. The magnitude of the increase and the abnormal percentage of serum lysyl oxidase activity were larger than those for serum prolyl hydroxylase and laminin P1. These results suggest that serum lysyl osidase activity is a more sensitive indicator of liver fibrosis than serum prolyl hydroxylase and laminin P1. (HEPATOLOGY 1991;14:1167-1173.)
Testicular Cancers in Children: Epidemiologic Characteristics
Authors: Frederick P. Li, M.D., Joseph F. Fraumeni, Jr., MD.
 3
Journal: JNCI Journal of the National Cancer Institute (1972)

To study risk (actors for testicular cancers in childhood, we examined 253 death certificates for U.S. children dying from these neoplasms, 1960–67, and 70 medical records from 14 institutions. Death rates exhibited an age peak in early childhood and a marked rise after puberty among whites. In contrast, persistently low rates occurred in black children and adolescents. Several reports have indicated a rising frequency of testicular tumors in young adults in recent decades, but mortality rates for children have remained stable. Embryonal carcinoma was the most common cell type reported in early childhood, and seminoma and choriocarcinoma were rare before puberty. Of the 70 children in the hospital series, 15 (21%) had inguinal hernia, undescended testis, or other genitourinary defects, a frequency which appears excessive. Since genitourinary defects also accompany Wilms' tumor, it is likely that the relationship between oncogenesis and teratogenesis is especially close in the developing genitourinary tract.
Arrhythmia Problems and Athletic Participation
Authors: Peter H. Gott
Journal: JAMA (1970)

<h3>To the Editor:—</h3> Dr. Rose's conclusions about cardiac conduction in "Relationship of Cardiac Problems to Athletic Participation" (<b>208:</b>2319, 1969) are not in agreement with information that we have reported (<i>Arch Intern Med</i><b>122:</b>340, 1968). There is convincing evidence that right bundle-branch block (RBBB) may actually be a rather common finding in normal athletes. It may be present in 20% to 25% of trained sportsmen. When intensive training is discontinued, RBBB may disappear. Dr. Rose's opinion that "subjects with [right] bundle-branch block should be withheld from strenuous sports until freedom from cardiovascular disease... can be demonstrated" seems over-conservative in face of current data. In addition, there is always the problem of how extensive an investigation should be carried out in a subject who is well-trained and shows good athletic performance and endurance. Second, arrhythmias are frequently seen in sportsmen and probably do not predispose athletes to serious conduction disturbances.
Nursing Burnout and Patient Safety
Authors: Deirdre Davis
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Raynaud's phenomenon and digital necrosis induced by interferon-alpha
Authors: C. BACHMEYER, D. FARGE, E. GLUCKMAN, J.M. MICLEA, S. ARACTINGI
Journal: British Journal of Dermatology (1996)

We report two patients treated with interferon-alpha who developed Raynaud's phenomenon followed by multiple digital necrosis. Arteriography of the legs revealed diffuse distal narrowing. Histological examination of the resected tissue showed ischaemic necrosis within the dermis and subcutaneous tissue without vasculitis. Resolution of the symptoms was observed when interferonalpha was withdrawn. Since other causes of Raynaud's phenomenon and digital necrosis were ruled out, a drug cause is likely. Raynaud's phenomenon should be looked for in patients treated with interferon-alpha. If present, immediate withdrawal of the drug is required.
Penetration Injury to the Heart
Authors: Joseph R. Wilder
Journal: JAMA (1980)

During the past 25 years, great progress has been made in saving patients with serious cardiac injuries. This study is based on nine consecutive cases of penetrating wounds to the heart treated successfully by surgical intervention at a community hospital with no facilities for cardiopulmonary bypass. Early surgery is advocated for patients suspected of having penetrating injury of the heart. (<i>JAMA</i>244:2080-2081, 1980)
Cardiac Catheterization in Congenital Heart Disease: A Clinical and Physiological Study in Infants and Children
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Personal Hygiene Applied.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bacteria, Yeasts and Molds in the Home.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal