tbuckley/cabot-search huggingface dataset:
TUBERCULOUS AND NON-TUBERCULOUS DISEASES OF THE RESPIRATORY TRACT.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
About 'Face'
Authors: Martha A. Richmond
Journal: JAMA (1989)

James, a student whom I admire, has a routine case of "senioritis." His symptoms include anxiety and cold feet: Should he attend the prestigious medical school to which he has been accepted in the fall? Should he go into medicine at all? As an undergraduate premed adviser, I usually have no problem with these counseling sessions. Although premed advisers debate how much of an advocacy role they should play for the medical profession, I have been an unabashed, although not blind, admirer of physicians and their profession. Despite all the changes in the health care "system," I still believed in the physician-patient relationships my advisees, like James, aspire to in their AMCAS essays. My daughter spent her first 10 months of life in a children's hospital and the next year and a half at home with a tracheostomy. I tell my students about the physicians who have cared for her
Hyperammonemia After Blood Transfusion
Authors: Zachary M. Rossfeld, Nathan R. Wright
Journal: Annals of Internal Medicine (2018)

Letters20 February 2018Hyperammonemia After Blood TransfusionZachary M. Rossfeld, MD and Nathan R. Wright, MDZachary M. Rossfeld, MDThe Ohio State University, Columbus, Ohio (Z.M.R., N.R.W.)Search for more papers by this author and Nathan R. Wright, MDThe Ohio State University, Columbus, Ohio (Z.M.R., N.R.W.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0641 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Picca notes that rocuronium has no sedative properties and is unlikely to have contributed to this patient's abnormal findings on physical examination. We agree but did not make it clear. However, we believe that clarifying that this patient's neurologic decompensation and near coma took place before receiving rocuronium is important.Dr. Hermann and colleagues raise a valid point in suggesting that it is unlikely that transferred ammonia from 3 units of packed red blood cells was solely responsible for this patient's hyperammonemia. Their addition of an adult-onset or preexisting urea cycle defect to the differential diagnosis is ... Author, Article, and Disclosure InformationAffiliations: The Ohio State University, Columbus, Ohio (Z.M.R., N.R.W.)Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L17-0093. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHyperammonemia After Blood Transfusion Zachary M. Rossfeld and Nathan R. Wright Hyperammonemia After Blood Transfusion Bertrand Hermann , Dominique Thabut , and Nicolas Weiss Hyperammonemia After Blood Transfusion Stephen M. Picca Metrics 20 February 2018Volume 168, Issue 4Page: 306KeywordsAmmoniaBlood transfusionComaConflicts of interestDisclosureForecastingHemorrhageRed blood cellsSedativesUrea ePublished: 20 February 2018 Issue Published: 20 February 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Ex vivo hepatic gene transfer in mouse using a defective herpes simplex virus-1 vector*1
Authors: B LU
Journal: Hepatology (1995)

A defective amplicon herpes simplex virus-1 (HSV-1) vector, HSV1ac, was used to transfer an E. coli lacZ reporter gene into primary hepatocytes. The lacZ gene was driven by the HSV immediate early (IE) 4/5 promoter. Use of the HSV1ac vector resulted in highly efficient gene transfer. Because difficulties in culturing primary hepatocytes impose limitations in ex vivo gene therapy, we sought to determine whether use of the HSVlac vector could simplify gene transfer. Therefore, we incubated HSVlac with primary hepatocytes in suspension and found that the lacZ gene was still transferred with great rapidity and efficiency. To examine lacZ expression in transduced hepatocytes in vivo, we used a mouse hepatocyte transplantation system. In congeneic recipients of primary hepatocytes transduced with HSVlac in suspension, the lacZ gene was expressed in liver and spleen up to 2 weeks. However, survival of transplanted hepatocytes, as well as persistence of HSVlac genome in recipient organs, was demonstrated for up to an 11-week duration of the experiment. These findings suggest that in vivo regulation of the HSV IE4/ 5 promoter was responsible for the short-term expression of lacZ, which should be overcome by the use of liver-specific promoters. Therefore, our results indicate the feasibility of hepatic gene transfer with a defective HSV-1 vector.
Correction
Journal: BMJ (1954)

RDICALJOUTALsexual tension herself than to live in continual frustration.It is important, however, for the medical attendant to make sure that a common source of confusion is not being over- looked-that is, that the woman is not just suffering from vaginal anaesthesia and would be able to get clitoral orgasm by digital stimulation, were this not, for some reason, being withheld.If such should be the case, her husband must be instructed how to provide this so that she can achieve orgasm either before coitus or after, whichever suits the couple best.
THE DECREASING BIRTH RATE IN NEW SOUTH WALES.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Apology
Authors: M Bernard]
Journal: Hepatology (1987)

EPATOLOCVday.This was confirmed by the fact that all patients were in positive sodium balance during the equilibration period (increasing body weight), and they needed diuretics to remove ascites after the end of the study.In any case, cirrhotics with ascites, although selected on the basis of their negative sodium balance, still represent a heterogeneous population as far as renal perfusion, effective volemia and cardiovascular responsiveness to neurohumoral systems are concerned.However, negative and positive sodium balance mark a real watershed and can be easily defined.Other pathophysiological abnormalities develop without gaps during the natural history of the disease, and in most cases are characterized only after a sophisticated experimental approach.We should, therefore, accept such a variability and be prepared for a thoughtful interpretation of results obtained in different studies.
The Test
Authors: Rimas Uzgiris
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antineutrophil cytoplasmic antibodies after liver transplantation for primary sclerosing cholangitis 1, B Gunson2, J Neuberger2, K Fleming3, R Chapman1, Dept. of Gastroenterology1 and Nuffield Dept. of Pathology3, Oxford Radcliffe Hospital, Oxford UK, Liver Research Laboratories2 Queen Elizabeth Hospital, Birmingham, UK
Journal: Hepatology (1995)
DEPARTMENT OF ERROR
Authors: Carlo Palmieri, Eric W-F Lam, David Vigushin, Charles Coombes
Journal: The Lancet (2004)

CORRESPONDENCEthe normal functioning of each organ, will lead to the development of organ-specific and receptor-specific SERMs, as well as novel classes of drugs, such as those targeting the coregulators (coactivators and corepressors).Although many questions remain unanswered about SERMs, and their role is still limited, they have provided proof of principle and represent the first steps away from current HRT to an era of molecular-based postmenopausal therapy.
NINTH ANNUAL CONVENTION OF THE TRI-STATE MEDICAL ASSOCIATION, HELD IN ENGLISH’S HALL, INDIANAPOLIS, SEPTEMBER 18,19, 20, 1883.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
To &lt;EMPH TYPE="ITAL"&gt;JAMA&lt;/EMPH&gt; Peer Reviewers and Authors—Thank You
Authors: Catherine D. DeAngelis
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Late physical, psychological and social consequences of ipilimumab treatment in advanced melanoma
Authors: A.H. Boekhout, M. Hauptmann, A.J.M. van den Eertwegh, G.A.P. Hospers, J.W.B. de Groot, M.J.B. Aarts, E. Kapiteijn, A.J. Ten Tije, D. Piersma, W.H.J. Kruit, K.P.M. Suijkerbuijk, F.W.P.J. Berkmortel, G. Vreugdenhil, R.H. Koornstra, E. Fiets, M. Lees, K.J.M. Janssen, L.V. van den Poll-Franse, C.U. Blank
Journal: Annals of Oncology (2017)
Evolving trends in non-clear cell renal cell cancer (RCC) epidemiology: A large registry analysis of 4,483 patients.
Authors: Ashok P. Pai, Monica Brown, Chong-xian Pan, Primo Lara
Journal: Journal of Clinical Oncology (2012)

374 Background: Non-clear cell (ncc) RCC is uncommon but includes a heterogeneous group of histologic subtypes such as papillary, chromophobe (Chr), medullary (Med), and collecting duct (CD) cancers. We used a large cancer registry to define nccRCC clinical features and outcomes, identify prognostic variables, and to generate hypotheses for further study. Methods: Invasive RCC tumors in the California Cancer Registry from 1998–2009 among adults &gt; 18 years of age (n=38,251) were analyzed. Baseline clinical and tumor variables were collected. Primary outcome measures were 3-year cause-specific (CSS) and overall survival (OS). Uni- and multivariate survival analysis were used to identify predictors of CSS and OS. Results: Of 38,251 RCC cases, 19,149 (50%) were of clear cell type; 14,619 (38.2%) were “unclassified”. Thus, 4,483 (11.7%) nccRCC cases were identified and included in this analysis. Of these, 3304 (73.7%) were diagnosed in 2004–09, suggesting a shift to more precise coding of histologic subtypes starting in the early 2000s. Histology distribution (n, %): papillary − 2,863 (63.9%); Chr − 1,507 (33.6%); and other including Med and CD − 113 (2.5%). Variables associated with significantly better OS and CSS (univariate analysis) were Chr histology, female sex, and higher socioeconomic status (SES). Significantly worse OS and CSS were seen in Med+CD, age &gt; 65 yrs, no nephrectomy (Nx), and higher stage. Non-hispanic blacks had significantly worse OS and CSS, while the “targeted therapy era” (2004–2009) was associated with better OS. Multivariate analysis showed the following to be independently associated with outcomes (all p &lt;0.001; Hazard Ratios [HR] shown for CSS and OS): Chr histology (0.48, 0.56), Med+CD histology (2.99, 2.42), no Nx (2.84, 3.18), regional stage (5.84, 1.98), distant stage (25.7, 7.67); and non-hispanic blacks (1.5,2 p=0.006; 1.25, p=0.03). Age &gt; 65 yrs (HR 1.78, p&lt;0.001) and high SES (HR 0.88, p=0.001) were associated with OS but not CSS. Conclusions: This is among the largest registry analyses of nccRCC ever performed, showing emerging trends in this uncommon RCC subset. Clinical variables associated with CSS and OS were identified that can inform the design of future clinical trials in nccRCC.
Artificial tobacco substitutes
Authors: G. B. Gori
Journal: JAMA (1975)

THE SEARCH for man-made materials that could substitute, wholly or in part, for the tobacco in cigarettes has been going on for almost two decades, but only in the last few years have such products commanded serious attention.<sup>1-3</sup> The reasons for this interest are twofold: these products, at least in their latest formulations, promise to reduce the toxic effects of smoke and offer the allure of potential economic advantage over the use of natural tobacco. <h3>Economic Considerations</h3> At present, however, the manufacturing of artificial tobacco substitutes (ATS) being offered commercially is sufficiently expensive to push their price range into the upper quartile of international tobacco prices (US patent 3,545,448; UK patents 1,113,979 and 1,244,441; Canadian patents 895,112 and 931,851). Consequently, a more evident advantage is that ATS can be supplied to suit a particular production schedule and, therefore, do not require the expensive storage procedures of tobacco. Furthermore, ATS
Cyclosporin A promising for transplantation
Authors: E. Pease
Journal: JAMA (1981)

Preliminary results from clinical trials being conducted at four US medical centers continue to indicate that cyclosporin A may have considerable potential as an immunosuppressive agent in the treatment of renal allograft rejection. "At this point there are only trends," says transplant surgeon John S. Najarian, MD, of the University of Minnesota Medical School, Minneapolis. "So far, however, the trend is that cyclosporin A is as good, if not better, than conventional therapy." Immunologic properties of cyclosporin A, a cyclic peptide derived from fungal metabolites, were first reported by J. F. Borel in 1976. Two years later, Roy Y. Calne, MD, of the University of Cambridge, England, pioneered the clinical use of the drug, believed to act selectively in early T lymphocyte differentiation and possibly on subpopulations of these T cells (<i>Br J Surg</i>1980;67:767;<i>JAMA</i>[MEDICAL NEWS] 1979;242:2268-2269). In the United States, clinical trials began in 1979 at the
MACRA: Big Fix or Big Problem?
Authors: J. Michael McWilliams
Journal: Annals of Internal Medicine (2018)

Letters6 February 2018MACRA: Big Fix or Big Problem?J. Michael McWilliams, MD, PhDJ. Michael McWilliams, MD, PhDHarvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts (J.M.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0628 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I appreciate Dr. Huffstutter's concerns about the consequences of the Merit-based Incentive Payment System for patient care. The extent to which providers will game this system remains to be seen, but the incentives to do so are clear. To say that quality measures must either impose substantial costs or be easily gamed presents a false dichotomy. That reporting costs are high—in part from fixed costs of measurement infrastructure—does not negate incentives for providers to minimize penalties or maximize bonuses by engaging in gaming behaviors, such as picking measures for which the added costs of performing well are minimal ...References1. McWilliams JM. Savings from ACOs—building on early success. Ann Intern Med. 2016;165:873-5. [PMID: 27723870]. doi:10.7326/M16-1846 LinkGoogle Scholar2. Newhouse JP, McGuire TG. How successful is Medicare Advantage? Milbank Q. 2014;92:351-94. [PMID: 24890251] doi:10.1111/1468-0009.12061 CrossrefMedlineGoogle Scholar3. Schwartz AL, Landon BE, Elshaug AG, Chernew ME, McWilliams JM. Measuring low-value care in Medicare. JAMA Intern Med. 2014;174:1067-76. [PMID: 24819824] doi:10.1001/jamainternmed.2014.1541 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts (J.M.M.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M17-0230. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMACRA: Big Fix or Big Problem? J. Michael McWilliams MACRA: Big Fix or Big Problem? J. Eugene Huffstutter Metrics Cited byReforming Physician Payments to Achieve Greater Equity and Value in Health Care: A Position Paper of the American College of PhysiciansBrian E. Outland, PhD, Shari Erickson, MPH, Robert Doherty, BA, William Fox, MD, and Lawrence Ward, MD, MPH, for the Medical Practice and Quality Committee of the American College of Physicians*Are Value-Based Payments Bumps in the Road or the Road to Nowhere? 6 February 2018Volume 168, Issue 3Page: 235-236KeywordsAccountable care organizationsBehaviorDisclosureGamesHealth care qualityMedicareMotivationPatientsPrimary care physicians ePublished: 6 February 2018 Issue Published: 6 February 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Role Of Mononuclear Phagocytes In The Pathogenesis Of Human Immunodeficiency Virus Infection
Authors: M. Meltzer
Journal: Annual Review of Immunology (1990)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
Management of Gout
Authors: Walter Bauer, Madan M. Singh
Journal: New England Journal of Medicine (1957)

ProbenecidProbenecid is a benzoic acid derivative with the structural formula shown in Figure 3. Its chief features in the treatment of chronic gout are listed in Table 4. It is a potent uricosuric agent.64 It has been shown that normally 90 per cent or more of the uric acid filtered by the glomeruli is reabsorbed by the renal tubules,65 , 66 and this is true even when plasma values are very much elevated.12, 64 , 67 This transport system can be effectively depressed64 , 68 by probenecid, and, as a result, the urinary excretion of urate is greatly enhanced.The drug is rapidly and effectively absorbed from the . . .