AB0480 LUPUS ORGAN DAMAGE: WHAT IS DAMAGED IN PATIENTS OF THE RUSSIAN FEDERATION, KIRGIZSTAN AND KAZAKHSTAN?
Authors: E. Aseeva, G. Koilubaeva, B. Issayeva, A. Mesnyankyna, N. Nikishina, S. Solovyev, A. Lila
Journal: Annals of the Rheumatic Diseases (2022)

Background Assessment of organ damage has become the standard outcome measure for morbidity and mortality in patients with lupus over the world including the Russian Federation (RF), Kirgizstan and Kazakhstan. Objectives The aim of this study was to compare organ damage of patients with systemic lupus erythematosus in the Russian Federation, Kirgizstan and Kazakhstan in real clinical practice. Methods 1102 SLE pts who fulfilled SLICC 2012 criteria were enrolled into the study. Disease activity was evaluated by SLEDAI-2K, while chronic damage was assessed by the Systemic Lupus International Collaborating Clinics Damage Index score (SDI). Results 400/600/102 Lupus pts from RF, Kirgizstan and Kazakhstan respectively were studied. Pts were predominantly female (91%/93%/98%) with a mean±SD age of 34,2±11,5/35,07±12,2/33,8±10,5 years (p=0,36; p=0,96) respectively. The mean disease duration (Мe) in RF/ Kazakhstan was 6 [3;12]/ 5[2;9] years (p=0,15), in Kirgizstan- 2[0,6; 7] years(p≤0,05). Kazakh pts (p=0,00) had higher disease activity (SLEDAI 2K) 17,6±8,8 than Kirghiz pts 15,1±8,3 and Russian pts 9,4±8,1. Patients from RF and Kazakhstan appeared to have a higher prevalence of damage compared with patients in Kirgizstan (Table 1). The Russian pts had a higher prevalence of Cataract 27%, damages in Cardiovascular system 77(19%), Diabetes mellitus 4% and premature gonadal failure 4%. Table 1. Organ damage in 1102 Lupus pts from RF, Kirgizstan and Kazakhstan Features Russian FederationN=400 KirgizstanN=600 KazakhstanN=102 Patients with damage, n (%) 223 (56%) 111(19%) 92 (90%) Organ damage Ocular 144 (36%) 7(1,1%) 14 (14%) Cataract 109(27%) 6(1%) 7(7%) Neuropsychiatric 46(11%) 24(4%) 27(27%) Skin 4(1%) 7(1,1%) 72 (71%) Renal 12(3%) 36(6%) 18(18%) Pulmonary 28(7%) 26(4%) 7(7%) Cardiovascular system 77(19%) 71(16%) 14(14%) Peripheral vascular diseases 48(12%) 26(4%) 3(3%) Musculoskeletal 96(24%) 6(1%) 39(39%) Diabetes mellitus 16(4%) 5(0,8%) 3(3%) Malignancy 7(2%) 0 2(2%) Premature gonadal failure 16(4%) 0 0 Predictors for organ damage, (М±SD) DAI SLICC =0 N=676 DAI SLICC &gt;1 N=426 P Age, years 31,29±10,13 36,57±12,01 &lt;0,0001 Disease duration, month 25,77±9,13 34,15±12,10 &lt;0,0001 Number of exacerbations 2,10±1,36 3,64±2,55 &lt;0,0001 Dosage of corticosteroids 34,90±21,61 42,12±16,68 0,03 Duration of corticosteroids, month. 69,97±42,30 83,29±66,01 0,04 *p &lt;0,05 Mann — Whitney test The pts from Kazakhstan had a higher prevalence of Neuropsychiatric 27% and renal 18% failures, skin 71% and Musculoskeletal 39% damages. The fewest damage was found out in Kirgiz pts. The risk factors for damage in our SLE pts such as age, disease duration, number of exacerbations, dosage of corticosteroids, duration of corticosteroids were determined by comparing pts with DAI SLICC =0 (676) with pts with DAI SLICC &gt;1 (426) ( Mann — Whitney test ) Conclusion Identification of variations in target organ predilection and accrual of damage across patients of differing ethnicity has implications for treatment, monitoring and prognostication. Disclosure of Interests None declared