tbuckley/cabot-search huggingface dataset:
Graduate Medical Education
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Esophageal Cancer in the Bantu of the Transkei Associated With Mineral Deficiency in Garden Plants&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1966)

Inspections were made of 29 gardens on which Bantu with esophageal cancer had largely subsisted for 15 to 30 years before their deaths and 29 gardens in the middle of large tumor-free areas nearby. The cancer gardens were less productive than the tumor-free gardens, showed severer leaf signs which indicated molybdenum deficiency, and the leaves of the maize had “withered end” only in these gardens. Molybdenum treatment reduced the incidence of withered end to one quarter. This remarkably close association between esophageal cancer and poor plant production may point to a more direct cause and is being investigated. Results of diagnostic leaf “injections” done in cancer gardens suggested that deficiencies, not only of molybdenum but also of iron, copper, zinc, and other trace elements, were widespread. The increase in crop after treatment proved that molybdenum deficiency had reduced the metabolic efficiency of beans (Phaseolus) and cucurbits to a small fraction of normal and had rendered maize prone to attack by two fungi known to be toxic to animals. These deficiencies may lead to the formation of nitrosamines, some of which cause cancer of the esophagus selectively in rats. A systematic preliminary chemical screening of Bantu Foods from cancer gardens for these and related carcinogens will therefore be carried out. The Appendix describes the cultural habits of Bantu insofar as they may lead to the use of possibly carcinogenic foodstuffs. The staple foods cultivated are maize, pumpkins, beans, and potatoes, and the women eke out a bare subsistence by consuming a wide seasonal variety of weeds, e.g., dandelions (Taraxacum), milky thistles (Sonchus), black nightshade (Solanum nigrum), many of which are known to be poisonous. Signs of malnutrition are common, and in the frequent periods of food shortage the women may well be forced to make use of more and more unsuitable (possibly carcinogenic) plants.
A Manual of Hygiene and Sanitation
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Harvey Lectures, Delivered Under the Auspices of the Harvey Society of New York, 1905-06.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Notice of Duplicate Publication
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Outbreak of Chickenpox in a Military Field Hospital-the Implications for Biological Warfare
Authors: N C Hepburn, T J G Brooks
Journal: Journal of the Royal Society of Medicine (1991)

An outbreak of chickenpox with spread to patients and staff on the isolation ward of a British field hospital during the Gulf war is described. The implications for the design and operation of field hospital isolation units should transmissible biological warfare agents be encountered in any future conflict are discussed.
Klüver-Bucy Syndrome
Authors: Hooshang Hooshmand
Journal: JAMA (1974)

IN 1937, Klüver and Bucy<sup>1</sup>described a striking behavioral syndrome in rhesus monkeys after bilateral temporal lobe ablations. It consisted of (1) psychic blindness or visual agnosia, (2) strong oral tendencies, (3) hypermetamorphosis or excessive tendency to react to every visual stimulation, (4) decrease in aggressive behavior and fear reaction, and (5) hypersexuality. This syndrome has subsequently been reported in experimental studies on other animals.<sup>2</sup>It has been reported in less than ten patients. Causes were bilateral temporal lobectomy<sup>3</sup>and bilateral temporal lobe damage from degenerative disorders, trauma, and encephalitis.<sup>4</sup>Lesser degrees of this syndrome are probably more common than realized because of the high incidence of bilateral temporal lobe damage in closed head injury. Unfortunately, practically no information is available about the treatment of patients with this condition. We recently encountered a patient suffering from posttraumatic Klüver-Bucy syndrome whose condition deteriorated on standard drug therapy
American White Protestant Clergy as a Low-Risk Population for Mortality Research&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;
Authors: King, Haltung, Locke, Frances B.
Journal: JNCI Journal of the National Cancer Institute (1980)

Journal Article American White Protestant Clergy as a Low-Risk Population for Mortality Research Get access Haltung King, Haltung King 4 2Biometry Branch, Division of Cancer Cause and Prevention, National Cancer Institute, National Institutes of Health, Public Health Service, U.S. Department of Health and Human Services, Bethesda, Md. 20205.3Department of Community Medicine and Family Health, School of Medicine, Graduate School, and Kennedy Center for Population Research, Georgetown University, Washington, D.C. 20007. 4Address reprint requests to Dr. King at the National Cancer Institute. Search for other works by this author on: Oxford Academic PubMed Google Scholar Frances B. Locke Frances B. Locke 2Biometry Branch, Division of Cancer Cause and Prevention, National Cancer Institute, National Institutes of Health, Public Health Service, U.S. Department of Health and Human Services, Bethesda, Md. 20205. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 65, Issue 5, November 1980, Pages 1115–1124, https://doi.org/10.1093/jnci/65.5.1115 Published: 01 November 1980
Injection of Collagenase in the Treatment of Herniated Lumbar Disk
Authors: Bernard J. Sussman
Journal: JAMA (1981)

Twenty-nine patients with persistent, low back and sciatic pain received intradiscal collagenase at a single abnormal disk space after two months of conservative therapy and two weeks of additional bed rest. Complete pain relief was achieved in six patients (21%), notable relief in 12 (42%), moderate in six (21%), and slight in one. Four patients (14%) who obtained no improvement by enzyme injection recovered after extruded disk fragments were removed from the spinal canal during a later operation. Pain relief after collagenase injection took place gradually over a two- to three-week period and was associated with some early backache. Improvement then continued at a slower rate for two to three months. There were no adverse effects of enzyme therapy. Injected disk spaces usually showed radiological narrowing. (<i>JAMA</i>1981;245:730-732)
NCCN News
Journal: Journal of the National Comprehensive Cancer Network (2022)

On June 17, 2022, NCCN convened an oncology policy summit in Washington, DC, on the topic of building a workplace that includes support for people with cancer and their caregivers.The program, which also featured a virtual attendance option, examined how workplace norms and expectations have changed in recent years, particularly since the onset of the COVID-19 pandemic.The conversation also examined the current legal and policy landscape, in addition to how generational shifts and an increasing number of cancer survivors in the workforce are leading to cultural changes throughout the United States."We need a cooperative and flexible approach from employers, payers, providers, and healthcare systems to ensure high-quality and equitable care for all our patients and their caregivers-meeting their needs with minimal disruption to their work and their income," said
Studies on Acute Leukemia and Infectious Mononucleosis of Childhood. IV. Continuous Propagation of Lymphoblastoid Cells From Spontaneously Transformed Bone Marrow Cultures&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1968)

Lymphoblastoid cells from spontaneously transformed bone marrow cultures have been propagated as long-term cultures. During a 5-year study, 40 continuous cultures, 11 from children with leukemia, 21 from children with infectious mononucleosis, 7 from children with various hematological disorders, and 1 from a child with hepatomegaly, were established by means of periodic supplementation with normal bone marrow fibroblasts. Suspension cultures were attempted with lymphoblastoid cells from 25 of these 40 cultures. Four cell strains were established, 2 of which developed into cell lines in that they have been maintained in log-phase growth during a period of 22 months for over 350 serial passages. The mode of continuous lymphoblastoid cell propagation either in monolayer cultures or in suspension is discussed.
Basic Medical Physiology.
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hospital Formulary System
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
History of the Discovery and Early Use of Radioactive Iodine
Authors: Earle M. Chapman
Journal: JAMA (1983)

I AM greatly honored with your invitation to address you on the history of the discovery of radioactive iodine and its early use in studies of thyroid function, especially the part in which I was involved with Robley Evans, when we defined the single effective dose of radioactive iodine, used alone and without other therapy, and also produced near-total destruction of then thyroid by intentional over-treatment with a single dose. On Nov 12, 1936, a historic luncheon was held in Vanderbilt Hall, billed as a colloquium on "What Physics Can Do for Biology and Medicine." There, Dr Karl Compton, president of the Massachusetts Institute of Technology (MIT), faced a group of students and faculty members. Seated about our table were Professor J. Howard Means, head of the Department of Medicine at the Massachusetts General Hospital (MGH), Dr Saul Hertz, then head of the Thyroid Clinic, Dr Jacob Lerman, and myself.
A possible mechanism for large stretch-induced increase in [Ca2+]i in isolated guinea-pig ventricular myocytes
Authors: F. Gannier, E. White, D. Garnier, J.-Y. Le Guennec
Journal: Cardiovascular Research (1996)

The aim of the study was to investigate the mechanisms responsible for provoking and maintaining a large, stretch-induced, increase in the level of resting calcium in single guinea-pig ventricular myocytes. In particular, we wished to test the relative importance of intracellular and extracellular sources of calcium in this phenomenon. Methods: Carbon fibres were used to stretch cells loaded with the fluorescent calcium indicator Indo-1. Sarcomere length and internal calcium activity ([Ca2+]i) were measured. Experimental results from our present and previous studies were compared with those predicted by the OXSOFT HEART (version 4) model of the guinea-pig ventricular myocyte incorporating a stretch-activated channel. Results: The stretch-induced increase in [Ca2+]i was found to be sensitive to removal of [Ca2+]0 and application of the Ca2+-channel blocker verapamil (1 μM). The phenomenon was not sensitive to disruption of sarcoplasmic reticulum function by ryanodine (1 μM) nor to the Na+ channel blocker TTX (30 μM). Our experimental findings were reproduced in the modelling study. Conclusions: The stretch-induced increase in [Ca2+]i is modulated by extracellular sources of Ca2+ rather than intracellular Ca2+ stores and is not indiscriminately sensitive to blockers of depolarizing current. We propose that the stretch-induced increase in [Ca2+]i may be triggered by activation of stretch-activated channels but that a combination of stretch-activated current and Ca2+-window current maintain the increased levels of resting [Ca2+]i.
Epidemiology of Congenital Rubella Syndrome
Authors: Stephen C. Schoenbaum
Journal: JAMA (1975)

Rubella vaccination policies are primarily directed at control of congenital rubella syndrome. In the United States, vaccination of children of both sexes, ages 1 through 12 years, has been recommended. This policy depends on the hypothesis that children are the major source of infection for pregnant women. If true, then as maternal parity increases one would expect an increasing prevalence of rubella antibody or an increase in the frequency of rubella syndrome in babies. A serologic survey of 3,081 pregnant women has failed to show an increase in prevalence of rubella antibody with increasing parity. Case-control studies comparing groups of children with rubella syndrome to birth certificate and hospital control groups also have failed to show an excess of multiparae among the mothers of babies with rubella syndrome. Thus, these results do not support the hypothesis that children are the major source of infection for pregnant women. (<i>JAMA</i>233:151-155, 1975)
Enzyme Activities in Normal, Dysplastic, and Cancerous Human Breast Tissues&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1984)

The activities of six different enzymes were compared in 29 normal, 34 dysplastic, and 80 cancerous (both primary and metastatic) human breast tissues; in MCF-7 cells; and in primary rat mammary tumors. Benign lesions generally showed enzyme activities similar to those of normal breast tissues. Malignant tumors had significantly increased activities of lactate dehydrogenase (LDH), malate dehydrogenase (MDH), fructose-bisphosphate aldolase, hexokinase (HK), pyruvate kinase (PK), and creatine kinase. Enzyme activity in the malignant tumor was always higher than that in apparently normal or fibrocystic tissue from the same patient. Enzyme activities did not correlate with the levels of estrogen and progesterone receptors. LDH, MDH, and HK were elevated to a similar extent in all the tissues examined. Conversely, PK was elevated to a much greater extent in cancerous tissues, particularly in MCF-7 cells. The elevated activities of these enzymes may have diagnostic potential, especially when tumor tissue and apparently normal tissue from the same patient are compared.
Awards, Appointments, Announcements
Journal: JNCI Journal of the National Cancer Institute (1996)

Smoking Prevalence in EuropeTobacco smokers make up a substantially higher proportion of the population in many European countries than in the United Stales.In the European Union overall, the proportion of men who smoke declined from 44% in 1987-1988 to 42% in 1994, while the smoking rate among women remained unchanged at 28% during that period.*In 1995, tobacco was responsible for an estimated 489,000 deaths in the European Union.Between 1950 and 2000, tobacco will have killed an estimated 20 million people there. Percentage of smokers by sex and country, 1994The
Hepatitis C Virus Infection Associated With Administration of Intravenous Immune Globulin
Authors: Joseph S. Bresee
Journal: JAMA (1996)

<h3>Objective.</h3> —To determine the risk of and risk factors for hepatitis C virus (HCV) infection among persons with immune deficiencies who had received intravenous immune globulin (IGIV) between March 1993 and February 1994. <h3>Design.</h3> —Retrospective cohort study. <h3>Setting.</h3> —An immunology program in a tertiary care hospital. <h3>Patients.</h3> —Of 341 persons who had received IGIV between March 1,1993, and February 22,1994, 278 (82%) were enrolled. The mean age for the enrolled persons was 9 years, and 99% had primary immune deficiencies. <h3>Main Outcome Measures.</h3> —Evidence of HCV infection by detection in sera of antibody to HCV and/or HCV RNA by reverse transcriptase polymerase chain reaction. <h3>Results.</h3> —Twenty-three (11%) of 210 persons who received the IGIV Gammagard (Baxter Healthcare Corporation, Deerfield, III) became infected compared with none of 52 persons who received exclusively other IGIV products (P=.01). In a multivariate analysis, HCV infection was associated only with Gammagard produced from plasma screened by second-generation (multiantigen) anti-HCV tests (P=.03). Hepatitis C virus RNA was detected in Gammagard, and the risk of transmission to recipients increased with increasing quantity of HCV RNA infused, from 0 for those who received no HCV RNA-positive lots to 29% for the quartile of patients receiving the greatest amount (P&lt;.001). At least 9 different lots of Gammagard were required to account for all cases. <h3>Conclusion.</h3> —Gammagard was the only IGIV product implicated in the transmission of HCV. Infection was associated with higher quantities of HCV RNA in Gammagard produced from second-generation anti-HCV-screened plasma. Further studies are needed to determine reasons for the infectivity of Gammagard, and viral inactivation and removal steps are needed to ensure the safety of IGIV products.