tbuckley/cabot-search huggingface dataset:
Poster Session 2: Advances in Imaging and Noninvasive Markers of Fibrosis; Bile Acids, Cholangiocyte Biology, and Experimental Cholestasis
Journal: Hepatology (2015)

2D-SWE (P=0.14).On day 2, the same was true for 72% and 79% (both P<0.01).Conclusion: LS assessed by both TE and 2D-SWE increases after a meal in alcoholic fibrosis most pronounced in patients with cirrhosis.There is a risk of fibrosis misclassification with food intake, increasing with the size of the meal, as does the return-time to baseline LS.Therefore, fasting more than three hours is recommended before LS measurement.Median liver stiffness ± IQR
The Distribution of Physicians
Authors: Charles D. Aring
Journal: JAMA (1972)

It should be obvious that physicians congregate, just as other people, in large cities "because that's where the money is," as Willie Sutton is reputed to have responded when asked why he persisted in robbing banks. A financial taint, if taint it be, also is one characteristic of the majority of medicine's clientele. No one doubts that business practices dominate the American scene. It hardly matters how one views these practices, they are not consistent with the sacred calling to serve all and be charitable in judging human frailty. A fact of life is that today's medicine is practiced in an industrial world, and the pressure of the system brings to the physician a consciousness of his own pecuniary interests. In a sense this makes him something of a man of business, and it becomes rather easy for him to earn a good living, yielding to its practices. Money as
Demonstrations of Physical Signs in Clinical Surgery
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Malignant Disease and Its Treatment by Radium
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Resource-Based Relative Value Scale
Authors: William C. Hsiao
Journal: JAMA (1987)

This article describes the design and methods of a study currently under way to develop a Resource-Based Relative Value Scale (RBRVS); an alternative basis for establishing the payment rate for the services and procedures (S/Ps) of physicians in medical and surgical specialties. Physician resource inputs to be measured include (1) S/P time, (2) pre-S/P and post-S/P times, (3) intensity, (4) practice costs, including malpractice premiums, and (5) the cost of specialty training. These five factors will be combined to produce an RBRVS denominated in nonmonetary units. In the initial phase of the study, data on time and intensity will be obtained through a national survey of physicians who perform these S/Ps. In the second, consensus phase of the project, the investigators will convene a panel of representatives of the medical profession, third-party payers, consumers, and other interested parties to examine areas of agreement and disagreement as to how an RBRVS should be used for policy purposes. The final results of this study are expected by the summer of 1988. (<i>JAMA</i>1987;258:799-802)
Treatment in General Practice
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contrasting Effects of Activated and Nonactivated Macrophages and Macrophages From Tumor-Bearing Mice on Tumor Growth In Vivo&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1980)

The effect of macrophages from normal and tumor-bearing mice on tumor growth was investigated with the use of an in vivo neutralization test. Macrophages from unstimulated and thioglycollate-stimulated peritoneal cavities (nonactivated macrophages) of normal mice enhanced growth of various syngeneic tumors [a 3-methylcholanthrene-induced transplantable fibrosarcoma from inbred C3HeB mice, a spontaneously originated transplantable melanoma (B16) from inbred C57BL/6 mice, and a radiation-induced lymphoma from inbred BALB/c mice]. This enhancing effect was not destroyed by irradiation of macrophages and was apparently mediated by macrophage secretory products. The effect appeared to be unrelated to immunosuppression and may have reflected direct stimulation of tumor cells. In contrast, Corynebacterium parvum-activated macrophages markedly inhibited tumor growth. Peritoneal macrophages from fibrosarcoma-bearing mice, which possessed tumor-inhibitory T-lymphocytes, enhanced tumor growth and abolished the effects of the tumor-inhibitory lymphocytes. Clearly, under certain conditions nonactivated macrophages interfered with the mechanisms of T-cell-mediated antitumor resistance in tumor-bearing mice.
Diseases of Muscle: A Study in Pathology
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Truth Is Stranger Than Fiction Department: The Surgeon, the Radiologist, the Authors, and JAMA Got it Right
Authors: John S. Najarian
Journal: JAMA (1990)

<h3>To the Editor. —</h3> When I read the article entitled "Reperfusion Pulmonary Edema,"<sup>1</sup>I was confused by the roentgenograms in Fig 2, in which the preoperative chest film is clearly that of a female patient and the postoperative chest film taken 5 hours after aneurysmectomy is a male patient. Is there a mix-up in the roentgenograms, or was some other surgical procedure performed as well?
Mortality in Childhood Hodgkin's Disease
Authors: Robert W. Miller
Journal: JAMA (1966)

THERE ARE peculiarities in the distribution of Hodgkin's disease with respect to age and sex which must reflect the influence of factors important in the genesis of the disease. MacMahon<sup>1,2</sup>has noted that (1) the age distribution in cases dying of Hodgkin's disease has two modes, the first of which occurs at 25 to 29 years of age, and (2) among 122 children with the disease before 10 years of age, the sex ratio (male:female) was almost 6:1 in contrast to the much lower value of about 1.5:1 for adults. To explore further the sex ratio in childhood and its relation to the age-peak at 25 to 29 years, we have examined US childhood mortality from Hodgkin's disease by<i>single</i>year of age. A dynamic change in rates was observed which has not previously been described. <h3>Methods</h3> Duplicates of punch cards containing information from the death certificates of all
The Effect of Chloral Hydrate on Bishydroxycoumarin Metabolism
Authors: Samuel A. Cucinell
Journal: JAMA (1966)

AMONG the causes of unexpected responses to coumarin anticoagulants are alterations in the rate of metabolism of these drugs. Several years ago certain barbiturates were shown to be capable of depressing the anticoagulant response to ethylbiscoumacetate and bishydroxycoumarin (Dicumarol)<sup>1,2</sup>in man. This depressed response correlates with an increased rate of metabolism of the anticoagulant drugs.<sup>3</sup>The present report suggests that chloral hydrate behaves in much the same manner as barbiturates. Since certain drugs increase the rate of metabolism of simultaneously administered bishydroxycoumarin, it is likely that discontinuance of the same drugs will result in a decrease in the rate of metabolism of bishydroxycoumarin. Such a decrease would result in an elevation of plasma levels of the anticoagulant which in turn would produce a prolongation of the prothrombin time. This mechanism appears to have precipitated a fatal hemorrhage in a patient treated with bishydroxycoumarin. <h3>Report of a Case</h3> A
Identification of Problem Drinking Among Drunken Drivers
Authors: Julian A. Waller
Journal: JAMA (1967)

Information about previous contact with community agencies, particularly contact involving drinking problems, was compared for 150 drunken drivers, 33 accident-involved drivers who had been drinking but were not arrested, 117 sober drivers involved in accidents, 131 drivers with moving violations, 19 drivers with citations plus arrest warrants, and 150 incident-free drivers. Screening criteria for problem drinkers were two or more previous arrests involving drinking or identification by a community agency as a problem drinker. These criteria were met by the following: drunken drivers, 63%; drivers with an accident after drinking, 50%; drivers with warrants, 30%; nondrinking drivers with an accident, 14%; persons with driving violations, 8%; and drivers with no incidents, 3%. High correlation was found between two or more arrests involving drinking and an impression of problem drinking. Eighty-seven percent of the drunken drivers were known to community agencies, most with multiple contacts starting before age 30.
Shock Treatments, Psychosurgery and Other Somatic Treatments in Psychiatry
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Factors That Influence the Public's View of Medical Care
Authors: Donald Apostle
Journal: JAMA (1967)

The study was performed to assess on a probability sample the attitudes of households in a large metropolitan community towards medical care and the medical profession. These attitudes were correlated with the frequency of use of various medical facilities, age, sex, and socioeconomic status. The respondents' perceptions of personal physicians, emergency departments, and the profession were found by factor analysis to be independently related. Personal physicians were viewed much more favorably than the profession. Women differ markedly from men in their view of a personal physician and the profession, ie, women have more positive views about their own doctor the more they see him, which is not true for men; at the same time a woman's view of the profession decreases the more she sees her personal physician. An attempt to identify nonusers of medical care revealed that the nonuse is primarily related to socioeconomic factors.
From the NIH: New procedure offers hope for infertile women
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From Xerosis to Nummular Dermatitis
Authors: Troy G. Rollins
Journal: JAMA (1968)

A universal problem, especially in temperate climates in the winter season, is dehydration of the skin. Untreated, it progresses from simple dryness to patches of pruritic, eczematous nummular dermatitis. Decreased humidity in an artificially heated environment, excessive bathing, decreased perspiration, and a decrease in natural skin oil contribute to the development of this dermatosis. There are individual variations in susceptibility to the condition, but it can develop in almost anyone. Although most common on the lower extremities, neither the trunk nor upper extremities is exempt. The condition is predominantly seen in adults, especially in older men. The symptoms vary with the severity of the condition. These may range from mild "prickling" discomfort to severe intractable pruritus. Early in the disease, examination reveals diffuse, fine dry scaling, with accentuation of the skin markings (Fig 1). If left untreated, the condition gradually evolves into erythematous nummular patches (Fig 2). The surfaces of
The Ankle Sprain
Authors: Milton Glickstein
Journal: JAMA (1971)

<h3>To the Editor.—</h3> In reply to Dr. Hilsinger's letter (<b>214</b>:1326, 1970), the severely sprained ankle is truly a problem. This is in no small measure an outcome of inadequate diagnosis and treatment. The orthopedic literature is liberally sprinkled with papers emphasizing necessity for strain x-ray films of the ankle if there is a high index of suspicion of complete ligament tears. The presence of a complete ligament tear is an indication for surgical repair in some hands but at the very least necessitates the application of a short leg cast. The use of halfway measures compounds the difficulties. The use of external supportive measures for incomplete or stretching injuries of these ligaments is of course perfectly acceptable.
Testosterone Replacement With Transdermal Therapeutic Systems
Authors: Glenn R. Cunningham
Journal: JAMA (1989)

Testosterone was administered transdermally to hypogonadal men under three protocols. In the first protocol, it was shown that peak levels of testosterone were achieved three to eight hours after scrotal application of a transdermal therapeutic system containing 5, 10, or 15 mg of testosterone, and values at 22 hours were greater than 60% of peak values. In the second protocol, patients were treated with 10-mg systems for four weeks followed by 15-mg systems for eight weeks. Serum samples were obtained three to five hours after application of the transdermal therapeutic system. Testosterone increased from a pretreatment level (mean ± SE) of 1.5 ± 0.4 nmol/L to 15.2 ±3.4 nmol/L at four weeks, 18.6 ± 3.3 nmol/L at eight weeks, and 17.3 ± 2.8 nmol/L at 12 weeks. The serum testosterone/dihydrotestosterone (DHT) ratio fell from 4.53 to 2.47 at four weeks and was similar at eight and 12 weeks, reflecting a greater rise in DHT with this route of treatment (normal testosterone/DHT ratio, 9/1 to 12/1). Eight patients were treated with the 15-mg systems for an additional year. Seven of the eight were compliant and maintained serum testosterone levels (at six time points from two to 12 months [mean ± SE]) ranging from 11.5 ±1.2 to 44.9 ±2.4 nmol/L. It was possible to achieve physiological serum levels of testosterone by transdermal administration of testosterone in two thirds of our hypogonadal men. (<i>JAMA</i>. 1989;261:2525-2530)
The Centre Thought to Control Sensory and Motor Activity in the Early History of Medicine
Authors: C E Quin
Journal: Journal of the Royal Society of Medicine (1992)

In Ancient Greek medicine the heart instead of the brain was sometimes thought to be the organ co-ordinating sensory and motor activity. The history of the origin of this erroneous idea is outlined. The relative importance of observations and theory in early medical investigations is discussed, and the anatomical dissections leading to the establishment of the brain as the centre of sensory and motor function are described.
Prophylaxis Against Gonorrhoeal Ophthalmia
Authors: Vernal G. Cave
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Dr. David S. Friendly of Children's Hospital, Washington, DC, in commenting on the article written about the high incidence of gonorrhea in the obstetric clinic by my colleagues and me (<b>210</b>:309, 1969) stated that we did not include "one of the most important reasons to routinely test prepartum patients, ie, to protect the eyes of their unborn babies." We fully endorse everything that Friendly has stated. We believe that this was one of several implications of our findings. We heartily reemphasize his suggestion for routine prophylactic techniques for the eyes of newborns and for rapid follow-up with smear and routine cultures in babies with eye discharges.
Inhibition of B-lymphocyte Clonal Proliferation by Spleen Cells from Plasmacytoma-Bearing Mice&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;, &lt;xref ref-type="fn" rid="fn3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1980)

This study demonstrated that spleen cells of inbred BALB/c mice with plasmacytomas inhibited proliferation of the B-lymphocyte colony-forming cells that were precursors of immunoglobulin-producing cells. The number of B-lymphocyte colonies/105 nucleated spleen cells was depressed in mice with plasmacytomas. The degree of suppression correlated with the size of the tumor. Spleen cells from tumor-bearing mice suppressed the formation of B-lymphocyte colonies by normal BALB/c spleen cells. Treatment of the myeloma spleen cell suspensions with anti-immunoglobulins, anti-theta, or 1,500 rads did not prevent the suppression. Spleen cells from tumor-bearing mice depleted of adherent cells by passage over Sephadex G-10 columns or adherence to plastic dishes did not retain their suppressive activity. Adherent spleen cells inhibited B-lymphocyte colony formation when they were either in direct contact with normal spleel) cells or separated from them by a layer of agar. These studies suggested that the immune suppression seen in plasmacytoma-bearing mice occurred partially at the level of the B-lymphocyte progenitor cell and that this suppression was mediated by an adherent mononuclear cell.
Community-Oriented Primary Care in the United States
Authors: Paul A. Nutting
Journal: JAMA (1985)

Community-oriented primary care (COPC) is a variation on the primary care model, which is characterized by the complementary use of epidemiologic and primary care skills to systematically address the health care needs of a defined population. A study by the Institute of Medicine developed an operational model of COPC and examined its feasibility under differing organizational and financial arrangements. Although COPC is usually associated with publicly funded programs for underserved populations, the study demonstrated its presence in the private sector as well. However, the financial structure of the practice remains a critical factor determining the particular expression of the model. The study points to the need for data describing the marginal cost and health impact of COPC, if this promising innovation is to become an important form of primary care practice. (<i>JAMA</i>1985;253:1763-1766)