AB0669 PREGNANCY OUTCOMES IN SYSTEMIC SCLEROSIS, SYSTEMIC LUPUS ERITHEMATOSUS AND BEHCET’S DISEASE
Authors: R. Goloeva, Z. Alekberova, L. Garzanova, O. Koneva, A. Lila
Journal: Annals of the Rheumatic Diseases (2022)

Objectives To clarify pregnancy outcomes in patients with systemic sclerosis (SSc), systemic lupus erythematosus (SLE) and Behcet’s disease (BD) using retrospective analysis. Methods The study group included 48 women with SSc, 47 with SLE 45 with BD aged 20-40 years, and the control group - 15 age-matching healthy women. SSc pts’ mean age was 32,9 [28;37] years, SLE pts’ 32,3 [29;36] years, BD pts‘ 31,3 [27;35] years, disease duration 6,3 [3;10], 9,8 [3;16] and 6,0 [3;8] years respectively. Completed by all women issue-specific questionnaire covered clinical symptoms of SLE, SSc, BD and details of obstetric history (characteristics of menstrual and reproductive function, presence of genital and extragenital pathology, previous pregnancies outcomes; previous intrauterine interventions, a history of coagulopathy). Results Retrospective analysis of thematic maps of 48 patients with SSc revealed: 28 patients had 77 pregnancies, 44 of which ended with the birth of children (13 by caesarean section in 9 patients); 3 women had 4 premature births at 28-35 weeks, one of which ended with perinatal death of the baby; 33 incomplete pregnancies in 19 patients: 28 medical abortions up to 12 weeks of gestation at the woman’s request; 5 pregnancy complications had 5 patients, spontaneous abortion - 3, undeveloped pregnancy - 2. The frequency of unfavorable pregnancy outcome was similar in patients with SSc and in the control group. Analysis of thematic maps of 47 patients with SLE: 27 patients had 68 pregnancies, 31 of which ended with the birth of children on time (12 by caesarean section in 9 patients); 3 women had 4 premature births at 27-33 weeks, two of which ended with perinatal death of the baby; 33 incomplete pregnancies in 18 patients: 15 medical abortions up to 12 weeks of gestation at the woman’s request, two women had 3 abortions for medical reasons (high activity of SLE); 15 pregnancy complications had 9 patients, spontaneous abortion had 8 pts, undeveloped pregnancy was observed in 7 women. The frequency of unfavorable pregnancy outcome was similar in patients with SLE and in the control group. 118 pregnancies in 35 pts with BD resulted in 75 live birth (6 cesarean section in 3 pts). Thirty-nine incomplete pregnancies were observed in 26 patients. Ten patients had 20 medical abortions on request before 12 weeks of gestation, one patient had an abortion due to medical reasons (rubella on the 7 th week of gestation), two patients had premature birth at 28 and 32 weeks with subsequent perinatal death of the baby. Fifteen out of 35 pts had 20 adverse pregnancy outcomes: 8 spontaneous abortion, 12 missed miscarriage. Nine patients had 12 Missed miscarriage at 6-11 weeks of gestation, one patient had 3 missed miscarriage, two had 2, and the others had 1 missed miscarriage. Six patients had 8 spontaneous abortions (early miscarriage). In the control group of 15 women, 7 had 15 pregnancies, 13 live birth of healthy children on time. Table 1. Pregnancy outcomes Pregnancy, n SSc, n=77 (%) SLE, n=68 (%) BD, n=118(%) Control, n=15 p Birth 44 (57,1)* 35 (51,5)* 77 (65) 13 (87)* 0,03 Abortion 28 (36,4)* 18 (26,5)* 21 (18) 0 * 0,01 Unfavorable pregnancy outcome 5 (6,4) 15 (22) 20 (17) 2 (13) ns Missed miscarriage 2 (2,6) 7 (10,3) 12 (10) 0 ns Spontaneous abortion 3 (3,9) 8 (11,8) 8 (7) 2 (13) ns Patients with SSc and SLE were more likely to terminate pregnancy of their own volition compared to the control group. Conclusion Patients with SSc and SLE were more likely to terminate pregnancy on their own volition compared to the control group. Unfavorable pregnancy outcomes were similar in groups. Disclosure of Interests None declared