AB0714 CLINICAL CHARACTERISTICS AND RISK FACTORS ANALYSIS IN PATIENTS OF TA WITH CORONARY ARTERY CALCIFICATION
Authors: S. Yang, L. Pan
Journal: Annals of the Rheumatic Diseases (2023)

<h3>Background</h3> Takayasu arteritis(TA) is a chronic inflammatory disease mainly involving large vessels, including the aorta and its main branches, pulmonary arteries and coronary arteries, which can usually lead to stenosis, occlusion, expansion, or aneurysm formation of the affected vessels <sup>[1-2].</sup>Studies have shown that 10-20% of patients with TA have coronary lesions detected by angiography.In fact, this situation is still underestimated, because most TA patients do not complete the coronary angiography examination due to the lack of cardiac symptoms, such as palpitations and chest pain <sup>[3]</sup>. Coronary artery involvement is a serious adverse factor of poor prognosis and increases mortality in TA patients, specifically showing coronary artery stenosis, occlusion, and coronary artery calcification(cac) <sup>[4]</sup>. Patients with high coronary calcification scores have an extensive coronary plaque burden, with a high risk of stress-induced ischemic events <sup>[5]</sup>. <h3>Objectives</h3> The aim of our study is to investigate the risk factors of cac in TA patients. <h3>Methods</h3> This retrospective study enrolled a total of 120 TA patients.All patients were divided into two groups according to the absence or presence of cac in TA patients (90 vs 30). we measured the Agatston score and compare clinical characteristics and ancillary findings between the two groups.A logistic model was applied to determine the risk factors associated with the incidence of cac in TA patients. <h3>Results</h3> A total of 30 patients with TA (25%) had cac.Age,medical history of hypertension and type of Numano V are the independent risk factors for developing cac in TA patients (OR [95% CI]1.080[1.020-1.143], p = 0.008; 5.457 [1.818-16.379], p = 0.002;7.827 [1.822-33.615], p = 0.006). However it's not associated with disease activity and clinical symptom. We counted the number of risk factors for each patient and measured the integral values of the cac, and found that the integral value of cac increased with the number of risk factors.We also counted the medication status of patients before admission,and found that patients with cac had a greater proportion of statin(50%vs. 28.9%, P=0.035) than patients without it.But there was no difference in using glucocorticoid and aspirin between the two groups. Glucocorticoid accumulation was also not statistically significant. <h3>Conclusion</h3> Age, hypertension and Numano type V are risk factors for developing cac in TA patients.It is recommended that arteria coronaria screen in TA patients with Numano type V should be actively treated as early as possible. The severity of cac will increase with the number of risk factors, and TA patients should be actively treated and strictly controlled with blood pressure levels. <h3>References</h3> [1]Kerr G. Takayasu's arteritis. Curr Opin Rheumatol 1994; 6:32-8. [2]de Souza AW, de Carvalho JF. Diagnostic and classification criteria of Takayasu arteritis. J Autoimmun 2014; 48-49:79-83. [3]Endo M, Tomizawa Y, Nishida H, Aomi S, Nakazawa M, Tsurumi Y, Kawana M, Kasanuki H. Angio graphic fifindings and surgical treatments of coronary artery involvement in Takayasu arteritis. J Thorac Cardiovasc Surg. 2003;125:570–7. [4]Wang H, Liu Z, Shen Z, Fang L, Zhang S. Impact of coronary involvement on long-term outcomes in patients with Takayasu's arteritis. Clin Exp Rheumatol. 2020 Nov-Dec;38(6):1118-1126. Epub 2020 Feb 14. [5]Mori H, Torii S, Kutyna M, Sakamoto A, Finn AV, Virmani R. Coronary Artery Calcification and its Progression: What Does it Really Mean? JACC Cardiovasc Imaging. 2018 Jan;11(1):127-142. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared.