tbuckley/cabot-search huggingface dataset:
Thyroid Hormone, Osteoporosis, and Estrogen
Authors: David S. Cooper
Journal: JAMA (1994)

As noted by Schneider and colleagues<sup>1</sup>in this issue ofTHE JOURNAL, thyroid hormone (levothyroxine sodium) is one of the most frequently prescribed drugs in the United States. Postmenopausal women are particularly prone to develop hypothyroidism, thyroid nodules, and thyroid cancers and are therefore far more likely than men to be taking thyroid hormone, either for replacement therapy or suppression therapy.<sup>2</sup>Unfortunately, older women are also at high risk for progressive bone loss from thyroid hormone, as documented in a number of previous studies and summarized in the article by Schneider et al.<sup>1</sup>The risk of bone loss is greatest in those women taking larger thyroid hormone doses and seems to be minimal in women taking more modest doses.<sup>1</sup>Although the degree of skeletal demineralization observed in many studies places some patients below the fracture threshold in terms of their bone density, no study to date
Mouse Myeloma Tumor Stem Cells: A Primary Cell Culture Assay&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1971)

Journal Article Mouse Myeloma Tumor Stem Cells: A Primary Cell Culture Assay Get access C. H. Park, C. H. Park Department of Medicine, University of Toronto; and The Ontario Cancer Institute, Toronto 284, Ontario, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar D. E. Bergsagel, D. E. Bergsagel Department of Medicine, University of Toronto; and The Ontario Cancer Institute, Toronto 284, Ontario, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar E. A. McCulloch E. A. McCulloch Department of Medicine, University of Toronto; and The Ontario Cancer Institute, Toronto 284, Ontario, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 46, Issue 2, February 1971, Pages 411–422, https://doi.org/10.1093/jnci/46.2.411 Published: 01 February 1971 Article history Received: 27 July 1970 Accepted: 04 November 1970 Published: 01 February 1971
MEDICAL EDUCATION IN THE UNITED STATES AND CANADA
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Program for the Care of Patients With Chronic Diseases
Authors: John W. Runyan
Journal: JAMA (1970)

Neighborhood clinics staffed by public health nurses have provided medical care to patients with certain stabilized chronic diseases (primarily, cardiac disease, hypertension, and diabetes) since 1963. Recently revised medical policies permit the nursing staff to assume even greater responsibility in rendering service which has increased the effectiveness of the program. The current policies permit the nurses to make changes in therapy, as set forth in protocols for each disease category, based upon their own observations and judgment, and, in addition, prescribe symptomatic treatment for minor complaints. Patients are referred to the Medical Center whenever the nurse finds the patient's condition warrants it. This program provides medical care of good quality, conveniently, and at a nominal cost, yet the physicians' time is greatly conserved. Some aspects of the program may have a wide application.
Carcinogenicity of Epoxides, Lactones, and Peroxy Compounds. Part II&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: van Duuren, B. L., Orris, L., Nelson, N.
Journal: JNCI Journal of the National Cancer Institute (1965)

Journal Article Carcinogenicity of Epoxides, Lactones, and Peroxy Compounds. Part II Get access B. L. van Duuren, B. L. van Duuren Institute of Environmental Medicine, New York University Medical Center, New York, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar L. Orris, L. Orris Institute of Environmental Medicine, New York University Medical Center, New York, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar N. Nelson N. Nelson Institute of Environmental Medicine, New York University Medical Center, New York, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 35, Issue 4, October 1965, Pages 707–717, https://doi.org/10.1093/jnci/35.4.707 Published: 01 October 1965 Article history Received: 10 February 1965 Published: 01 October 1965
Papovavirus in Epitheliomas Appearing on Lymphoma-Bearing Hamsters: Lack of Association With Horizontally Transmitted Lymphomas of Syrian Hamsters&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: J. H. Coggin, Jr., B. M. Hyde, L. S. Heath, S. S. Leinbach, E. Fowler, L. S. Stadtmore
Journal: JNCI Journal of the National Cancer Institute (1985)

Several epizootics of lymphoma occurred in a colony of LVG hamsters contaminated with an unusual, horizontally transmitted, subviral, lymphomagenic agent. Hamsters with horizontally transmitted lymphoma, or others housed with these hamsters, occasionally developed epitheliomas bearing an unclassified papovavirus. The possibility that the virus present in the wartlike structures in our hamster colony could activate lymphoma was tested, and a search was conducted for mature virions in passaged epitheliomas and lymphomas. The agent responsible for the skin epitheliomas in our hamster facility was an icosahedral, 36-nm virion compatible with the morphology of a polyomavirus or simian virus 40. Horizontally transmitted lymphoma cells and epitheliomas contained hamster papovavirus (HaPV) DNA sequences detected by dot hybridization; however, such sequences were not found in extracts of lymphomas with oncogenic potential. In contrast to reports by other investigators, infection of hamsters with the papovavirus present in primary epitheliomas produced epitheliomas in good yield but was not reproducibly associated with lymphoma induction. These data confirm the observation that the HaPV is the causative agent of epitheliomas, but they suggest clearly that HaPV is not the agent responsible for lymphoma-genesis.
Munchausen Syndrome With Renal Stones
Authors: Richard L. Atkinson
Journal: JAMA (1974)

HEMATURIA as a presenting symptom of Munchausen syndrome is unusual. Ireland et al,<sup>1</sup>in a review of all the reported cases of Munchausen syndrome, could only find four cases with hematuria. Several cases with hematuria have been reported since then,<sup>2-5</sup>but we have found no cases previously reported in which the patient presented an actual renal stone that was supposedly passed. We have treated such a patient who exhibited factitious urinary tract infection, hematuria, and a number of stones that she "passed." <h3>Report of a Case</h3> A 37-year-old white woman was referred to Walter Reed General Hospital (WRGH) from a nearby Army Hospital because of frequent passage of kidney stones. She gave a history of bilateral stag-horn calculi requiring nephrotomies when she was 16 and 17 years old. Since then, she allegedly passed one or two stones a year until she had a nephrectomy for a nonfunctioning right
Oxyphil Adenoma and Primary Hyperparathyroidism
Authors: Harold M. Selzman
Journal: JAMA (1967)

A 65-year-old white man had hyperparathyroidism associated with an oxyphil adenoma. Review of the literature reveals this cell type to be a rare cause of parathyroid hyperactivity. Oxyphil cells have been considered inactive, or involutional forms. Electron microscopic examination of this tumor demonstrates well-defined organelles and membrane-limited secretory granules within the oxyphil cells suggesting a secretory function. The fine structure in oxyphil cells in normal parathyroid glands lacks such a well defined system. It is suggested that this tumor reflects an alteration of these cells resulting in the production of excess hormone secretion and clinical hyperparathyroidism.
Cancer in Brazzaville, the Congo
Authors: A. J. Tuyns, P. Ravisse
Journal: JNCI Journal of the National Cancer Institute (1970)

A series of 508 cases of cancer observed in the Congo during 1965 and 1966 is analyzed. Liver cancer appears to be the most frequent cancer in males and one of the most frequent in females; the minimum annual crude incidence rates are 11 and 4 per 100,000, respectively. These are the highest known crude incidence rates after those of Mozambique and Johannesburg (Bantu).
Why We Behave Like Human Beings.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Laparoscopic cholecystectomy.
Authors: J Kiil, O Thorlacius-Ussing, H Høstrup, P A Videbaek, L Vestergaard
Journal: BMJ (1991)

Forty-one patients with uncomplicated gall stone disease were laparoscopied with the object of cholecystectomy. The procedure was accomplished in 36 patients, but the operation had to be transformed to a conventional open operation in five: Fibrosis made dissection of the gall bladder hazardous in four and bleeding during the procedure made immediate laparotomy necessary in one patient, whose postoperative course was uneventful. The median operating time was 100 minutes, range was 60-250 minutes. The only operative complication was bleeding from a trocar puncture hole on the first postoperative day which stopped spontaneously in one patient. Eighteen were sent home on the first postoperative day and 12 patients on the second day. Peroperative cholangiography was performed employing the Olsen-Reddick cholangiography forceps. We have designed a special catheter, which greatly facilitates the procedure. The procedure was accomplished in 27 of 32 planned cases. Two patients had common bile duct or common hepatic duct stones. A trans-sphincteric endoprosthesis was applied through the cholangiography forceps in both patients, to prevent postoperative bile duct outlet obstruction. The endoprosthesis made the following endoscopic sphincterotomy, which was performed at a convenient time rapid and safe. The stones were extracted and the prosthesis removed on the same occasion. A reliable flushing system was developed on the basis of the "Kidde" automatic tourniquet frequently used in orthopaedic surgery. All patients were seen in the outpatient clinic 1 month after the operation. Superficial infection in the trocar holes in ten patients were the only problem the patients had encountered and all had returned to their normal work.(ABSTRACT TRUNCATED AT 250 WORDS)
Stuttering and Acquired Immunodeficiency Syndrome
Authors: Lori Fantry
Journal: JAMA (1990)

<h3>To the Editor.—</h3> I report a case of stuttering in a patient infected with the human immunodeficiency virus. The stuttering subsequently resolved with treatment with zidovudine. <h3>Report of a Case.—</h3> A 27-year-old Hispanic man positive for human immunodeficiency virus antibody presented with complaints of weight loss, fever, fatigue, diarrhea, difficulty with memory, and "haziness of mind." The results of the examination were remarkable for a temperature of 37.7°C, cervical and inguinal lymphadenopathy, and an inability to recall four objects after 3 minutes. Remarkable laboratory results were a T4-lymphocyte count of 240, a cytomegalovirus titer of 3.74 enzyme-linked immunosorbent assay units, and a negative rapid plasma reagin test. A lumbar puncture done 7 weeks later, because of continued memory loss and fever, produced cerebrospinal fluid with 2 red blood cells and 7 white blood cells per high-power field. Cultures of cerebrospinal fluid for fungi and bacteria were negative, as were
Haemophilus influenzae Type C Meningitis With Sepsis
Authors: Christopher J. Drayna
Journal: JAMA (1980)

ALTHOUGH<i>Haemophilus influenzae</i>is a common cause of meningitis in children younger than 2 years, it is an uncommon cause of meningitis in adults. In reviewing the world literature in 1965, Snyder and Brunjes<sup>1</sup>found 79 cases of<i>H influenzae</i>meningitis and added 18 of their own. The vast majority (more than 95%) of<i>Haemophilus</i>strains in the pediatric age range are type B infections.<sup>2</sup><i>Haemophilus</i>-related diseases in the adult have a somewhat lower frequency of B strains. The exact percentage remains uncertain because specific capsular typing, a technique long available, is not performed routinely in many clinical laboratories. A case of<i>H influenzae</i>type C meningitis with sepsis in an adult is presented here. In my review of the literature, this serotype has previously been described in only one case of bronchopneumonia.<sup>3</sup> <h3>Report of a Case</h3> A 54-year-old woman visited numerous physicians. She had symptoms
Cycad Toxicosis in Chickens&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: V. L. Sanger, M. G. Yang, O. Mickelsen
Journal: JNCI Journal of the National Cancer Institute (1969)

In one experiment, day-old chicks were fed continuously 2 or 5% cycad-seed kernel or 2 or 5% husk in the diet until they were 14 days old. All 4 groups gained less weight than the controls, but in the group fed 5% kernel, gains were the most severely depressed. The combined weight of this latter group was only 37% of the weight of the controls. Microscopic lesions were minimal. In another experiment, chickens were fed 0.5 or 1.0% kernel or 0.5 or 1.0% husk for 28 and 68 weeks. Those fed cycad and those fed a control diet did not differ significantly in weight. Lesions in those chickens fed for 68 weeks were not more severe than those fed for 28 weeks. They included focal necrosis and fatty degeneration in the liver and cystic renal tubules with cellular atrophy. These lesions were mild compared to those produced in rats by the feeding of cycads. No chickens had tumors attributable to cycads, nor did they have clinical signs of central nervous system disturbances.
Tay-Sachs Disease
Authors: John S. O'Brien, Shintaro Okada, Agnes Chen, Dorothy L. Fillerup
Journal: New England Journal of Medicine (1970)

A fluorometric method showed the activity of hexosaminidase A in human serum to be markedly deficient in serum specimens from nine patients with Tay–Sachs disease. Parents (obligate heterozygotes) of children with Tay–Sachs disease had levels of hexosaminidase A that were intermediate between those found in affected children and those in control subjects. No overlap was found between values for this enzyme in serums from heterozygotes, healthy controls and homozygotes. Hexosaminidase A activity was not reduced in the serum of children with related disorders (Gaucher's disease, Hunter's and Hurler's syndromes, metachromatic leukodystrophy and juvenile amaurotic familial idiocy), indicating the value of the assay in the differential diagnosis of infantile cerebral degenerative disorders. Although preliminary, the results suggest that the assay may be useful in the detection of persons who are heterozygous for the gene for Tay–Sachs disease.
Enhanced Success Rate of Transplantation With Human Tumors in Cyclophosphamide-Treated Nude Mice&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Boudewijn J. M. Braakhuis, Maria M. Nauta, Johannes C. Romijn, Derk H. Rutgers, Truus Smink
Journal: JNCI Journal of the National Cancer Institute (1986)

Immunosuppression was investigated to enhance the take rate of various human tumor types in nude BALB/c or B10.LP/Cpb mice. Cyclophosphamide (CY), known as an immunosuppressive agent', was injected ip at a dose of 100 mg/kg 24 hours prior to subcutaneous implantation of tumor fragments obtained from established xenograft lines or from patients. In 3 out of 8 ovarian adenocarcinoma tumor lines, with a take of 50% or less in untreated control animals, tumor take was significantly increased by CY treatment to values between 75 and 100%. No effect of CY treatment on tumor take was seen with squamous cell carcinomas of the head and neck region and with lung and prostatic carcinomas. The growth rate of these xenografts was not affected by CY pretreatment. These results indicate that immunologic mechanisms indeed can play a role in the inhibition of tumor growth in nude mice. CY pretreatment may enhance the success rate of transplantation, but this effect appears to be limited to certain tumors.
Transactions of the Royal Academy of Medicine in Ireland.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Properties of Arginase From SV40- Induced Hamster Fibrosarcomas and Hamster Liver Tissues&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1971)

Arginase was partially purified and characterized from SV40-induced fibrosarcoma and hamster liver tissues. The level of arginase activity was elevated in the fibrosarcoma tissue. Two fractions containing arginase activity were obtained from both tissue sources by chromatography on CM-cellulose columns. The molecular weights of these fractions were determined. Fractions I and II from the same tissue exhibited essentially identical Michaelis constants for arginine, as well as similar inhibitor constants for ornithine and canavanine. However, differences were noted when Michaelis and inhibitor constants of fibrosarcoma and hamster liver tissue were compared.
Self-induced Vomiting and Laxative and Diuretic Use Among Teenagers
Authors: Joel D. Killen
Journal: JAMA (1986)

Bulimia (binge-purge syndrome) is a recently described but apparently common eating disorder. Purging behaviors associated with bulimia can cause serious medical complications. Prevalence data on purging behaviors are lacking for younger adolescents. A survey was conducted with 1,728 tenth-grade students to assess their attitudes about eating, dieting, weight control, and frequency of purging. Height, weight, and skin-fold thicknesses were also measured. Thirteen percent reported purging behavior. Female purgers outnumbered male purgers 2 to 1. Male purgers were significantly heavier than male nonpurgers and had significantly greater skin-fold thicknesses and weight/height<sup>2</sup>ratios. Both male and female purgers felt guiltier after eating large amounts of food, counted calories more often, dieted more frequently, and exercised less than nonpurgers. Our findings suggest that an alarming number of young adolescents may employ unhealthy weight regulation strategies. Physicians who see adolescents should look for the presence of the attitudes and behaviors that characterize bulimia; this will enhance the likelihood of detection of the disorder and prevention of its complications. (<i>JAMA</i>1986;255:1447-1449)