tbuckley/cabot-search huggingface dataset:
Ethics of a Randomized Trial of Periconceptual Vitamins
Authors: Ronald G. Munger
Journal: JAMA (1989)

<h3>To the Editor.—</h3> Mulinare and colleagues<sup>1</sup>reported an association between periconceptional use of multivitamins by women and subsequent reduced risk of neural tube defects among their infants. Dr Holmes,<sup>2</sup>in an accompanying editorial, interpreted this study as finding no protective effect of vitamins among black women, then speculated that genetic differences between whites and blacks may result in a greater responsiveness of whites to periconceptional vitamin supplements. Dr Holme's speculation is based on a failure to recognize the large type II error associated with small sample sizes and a faith in genetic determinism with no supporting data. Any inferences regarding blacks in this study are hazardous because only 28 blacks were included among the cases reported in Table 2 of the article and only 2 of these reported vitamin use. If the true odds ratio among black women was similar to that found among white women (0.4), then
Who Really Determines Your Patients' Prescriptions?
Authors: Marvin Moser
Journal: JAMA (1991)

THE WIDESPREAD publicity and public response to a recent study by Pollare et al,<sup>1</sup>who described changes in serum cholesterol levels and glucose metabolism with hydrochlorothiazide compared with an angiotensin converting enzyme inhibitor, captopril, serve to highlight the impact of the media and pharmaceutical industry on the practice of medicine. Patients' reactions were predictable following a front-page story in the<i>New York Times</i>, articles in more than 200 newspapers, and national television coverage. Many patients expressed concerns about their treatment despite the fact that their hypertension may have been well controlled by diuretic therapy for many years. As physicians who have had a long-standing interest and commitment to improving the treatment of hypertension, we are concerned about the manner in which the results of this study were disseminated to the public and to the medical profession. The methods used represent a clear attempt to market a product directly to
The Cardiac Conduction System in Unexplained Sudden Death
Authors: Maurice Lev, Saroja Bharati
Journal: Annals of Internal Medicine (1991)

Letters15 November 1991The Cardiac Conduction System in Unexplained Sudden DeathMaurice Lev, MD, Saroja Bharati, MDMaurice Lev, MDSearch for more papers by this author, Saroja Bharati, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-10-834 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Our book, The Cardiac Conduction System in Unexplained Sudden Death, was recently reviewed in Annals (1). Our book's aim, as noted in the preface, was to give our experience with the histologic findings of the conduction system in unexplained sudden death in young, healthy persons. Further, we hoped to stimulate the development of new technologies to identify these lesions in the living and to shed light on the mechanisms of sudden death in young, healthy persons. The reviewers appear to have missed this message.Our book is unique because it represents knowledge accumulated by us during several...References1. RuffyCraven RC. Review of The Cardiac Conduction System in Unexplained Sudden Death , by Saroja Bharati and Maurice Lev. Ann Intern Med. 1991;115:335-6. LinkGoogle Scholar2. Garson A. Review of The Cardiac Conduction System in Unexplained Sudden Death by Saroja Bharati and Maurice Lev. PACE. 1991;14:862. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Christ Hospital and Medical Center Oak Lawn, IL 60453 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1991Volume 115, Issue 10Page: 834-834KeywordsLesionsSudden cardiac death Issue Published: 15 November 1991 PDF DownloadLoading ...
The National Intern Matching Program
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Primary and Secondary Syphilis--United States, 2000-2001
Journal: JAMA (2002)

In October 1999, CDC, in collaboration with other federal partners, launched the National Plan to Eliminate Syphilis in the United States. In 1998, Congress initiated funding for the syphilis elimination effort. Syphilis elimination is defined as the absence of sustained transmission (i.e., no transmission after 90 days of the report of an imported index case). The national goal for syphilis elimination is to reduce primary and secondary (P&S) syphilis to <1000 cases (rate: 0.4 per 100,000 population) and to increase the number of syphilis-free counties to 90% by 2005. To describe the epidemiology of syphilis in the United States, CDC analyzed notifiable disease surveillance data for 1999. This report summarizes the results of that analysis, which indicate that, in 1999, P&S syphilis declined to a rate of 2.5 cases per 100,000 population, the lowest rate ever reported, and that syphilis transmission increasingly is concentrated in a few geographic areas.
Effect of Immunomodulation on the Fate of Tumor Cells in the Central Nervous System and Systemic Organs of Mice. Distribution of [<sup>125</sup>I]5-lodo-2′-deoxyuridine-Labeled KHT Tumor Cells After Left Intracardial Injection<xref ref-type="fn" rid="fn2">2</xref>
Authors: Frances K. Conley
 4
Journal: JNCI Journal of the National Cancer Institute (1982)

The effect of systemic immunomodulation on tumor cell arrest and retention in the central nervous system was studied by following radioactively labeled tumor cells. KHT mouse sarcoma tumor cells were labeled in vitro with [125I]IdUrd, and 1 × 105 tumor cells were injected into the left side of the hearts of syngeneic C3H mice. Experimental groups consisted of untreated normal mice, mice pretreated iv with Corynebacterium parvum, and mice chronically infected with Toxoplasma gondii; in this model both groups of immunomodulated mice are protected from developing systemic metastatic tumor, but only Toxoplasma-infected mice have protection against metastatic brain tumor. At time intervals from 1 to 96 hours, groups of mice from each experimental group were killed, and the brain and other organs were monitored for radioactivity to determine the number of viable tumor cells that had been present at the time of death. Normal mice demonstrated significant retention of tumor cells in the brain and kidneys plus adrenals at 96 hours. By contrast, in both groups of immunomodulated mice tumor cells were rapidly eliminated from systemic organs, but tumor cells were significantly retained in the central nervous system even at 96 hours after tumor cell injections. The results indicated that generalized immunomodulation had more effect in elimination of tumor cells from systemic organs than from the brain and that the elimination of tumor cells from the brain in Toxoplasma-infected mice was a delayed phenomenon.
Correction: Article on Prognostic Significance of Metastasis-Associated Protein SlOOA4 in Prostate Cancer
Journal: Clinical Cancer Research (2005)

The article on SlOOA4 and prostate cancer in the January 1, 2005, issue of Clinical Cancer Research was incorrectly labeled a report from the Food and Drug Administration. The article has no connection to the Food and Drug Administration.Saleem M, Adhami V, Ahmad N, et al. Prognostic significance of metastasis-associated protein SIOOA4 (Mts1) in prostate cancer progression and chemoprevention regimens in an autochthonous mouse model. Clin Cancer Res 2005;11:147–55.
The British Society of Gastroenterology
Authors: H Howat, Arthur The Sir, Robert Crane, R Holmes, John Lennard-Jones, A Harper, Sheila Sherlock, M Atkinson, A Connell, A Ugolev, L Dembling, S Goulston, K Heinkel, J Landor, J Myren, C Edmonds, T Low-Beer, L Lack, M Tyor
Journal: Gut (1969)

Drasar2 that some bacterial species (Bacteroides, Streptococcifaecalis, Veillonella, and Clostridium welchii) are capable of dehydroxylating bile acids, whereas Midtvedt and Norman3 were unable to demonstrate dehydroxylation by these organisms.
Nutrition and Physical Fitness
Journal: JAMA (1935)

This useful and thoroughly practical book now appears with revisions and amplifications particularly on the subject of vitamins. The dominant trend in the book is still maintained. It is the author's purpose to show mainly how nutritional knowledge may be used intelligently in everyday life for the building of positive health. The book is well balanced and written in a simple and direct manner. The author has anticipated the reader's desire not only for theoretical information concerning nutrition but also for practical data concerning foods and their methods of preparation. The text is divided into five parts, the first three being concerned with the fundamentals. The first part deals with qualitative aspects of the diet, next how this should be supplied in terms of calories and percentage composition and, concluding this section, a discussion of how this is made available to the body cells. The last two sections are practical
Migration of Medical Manpower
Authors: John Z. Bowers
Journal: JAMA (1970)

An international conference on the Migration of Medical Manpower, sponsored by the Josiah Macy, Jr. Foundation of New York city, met at the Villa Serbelloni, Bellagio, Italy, on Oct 4 to 9, 1970. There were 19 participants representing 14 countries —Australia, Canada, Chile, Colombia, Great Britain, India, Iran, Jamaica, Pakistan, the Philippines, Spain, Thailand, Turkey, and the United States—and the World Health Organization. The papers and discussions focused on the migration of recent medical graduates from developing (donor) to developed (recipient) countries, who go on the basis of individual choice; without government sponsorship; and who usually have no assured appointment in their homeland upon the completion of their overseas training. It was evident that sponsored visitors present no major problem. The conference participants agreed that it is important that there should be no governmental or statutory restrictions on the international movement of doctors. However, the continued and significant loss of
Woman Physician-Politician Is New Head of WHO
Authors: Joan Stephenson
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Syphilis and Leprosy
Authors: Katherine A. Murray
Journal: JAMA (1982)

<h3>To the Editor.—</h3> I was pleased to see one of the recent issues ofThe Journalcontaining a good amount of material on sexually transmitted disease (STDs). Within one issue, there were two articles on atypical manifestations of gonococcal infections (1981; 246:242, 246), an article on secondary syphilis (1981;246:250), and an announcement on the First STD World Congress for November 1981 (1981; 246:217). One dermatology question in the same issue concerned a case of presumed alopecia areata in a 26-year-old man with oral ulcers, cervical lymphadenopathy, arthralgias, anemia, and, possibly, hepatitis (1981; 246:284). All of these signs and symptoms may occur with secondary syphilis, although the moth-eaten alopecia of syphilis may involve more diffuse thinning of the hair rather than the "exclamation point" hairs seen in bald spots in alopecia areata.<sup>1</sup>Syphilitic alopecia, of course, is accompanied by positive serological test results. Since syphilis is so easily treated in
Blueprint for the Future
Authors: Walter C. Bornemeier
Journal: JAMA (1971)

Today I should like to review briefly some of the recommendations that I have made to this House of Delegates and some facts and figures that I have emphasized in talking to the public during the past year. Then I will outline what I believe to be the blueprint for the future of medical practice in this country. Many things have been said and written about manpower. I have told the public over and over that medical school enrollment is being doubled in many areas and increased in all areas, that by the end of this decade we hope to have enough doctors to provide medical care to every area of the country. Some recently published data seem to indicate that we are still not moving fast enough. According to an article in the June 14 issue of<i>U.S. News &amp; World Report</i>, the population down-trend has been reversed by
A Reference Handbook of the Medical Sciences Embracing the Entire Range of Scientific and Practical Medicine and Allied Science.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Employee Rubella Screening Programs in Arizona Hospitals
Authors: Jeffrey J. Sacks
Journal: JAMA (1983)

One year after voluntary guidelines on rubella screening of hospital employees were issued by the Arizona Department of Health, a survey of 68 members of the Arizona Hospital Association was conducted, with an 81% response. Some form of employee rubella screening was present in only 49% of responding hospitals. Of the screening hospitals, 70% of programs had a mandatory aspect for selected employees. Administrative logistics, cost, problems encountered, and the quality and coverage of the program varied substantially among the different hospitals. Fewer than half of the screening hospitals had programs for physicians, students, or volunteers. Verbal histories of immunization or serological tests, although notoriously unreliable, were accepted by 14% of the screening hospitals. Half of the nonscreening hospitals plan to implement programs in the future. Reasons given for not establishing rubella screening programs include cost, no pediatric or obstetric service, liability issues, high turnover, and no previous case of rubella in an employee. Three hospitals (all screening) reported they had had a case of rubella in an employee. The data suggest slow partial compliance with recommendations for rubella screening in hospitals. (<i>JAMA</i>1983;249:2675-2678)
Canadian Pharmacy in Preconfederation Medical Legislation
Authors: G. R. Paterson
Journal: JAMA (1967)

No laws governed the practice of medicine in the early days in New France. Letters patent from the King, and even degrees, were easily obtained by those who would practice as physicians, surgeons, apothecaries, midwives, and bonesetters. Many of the more qualified persons were connected with the religious orders or with the military.<sup>1(p14)</sup>In 1658, Jean Madry, "a practising physician of the Corporation of Barber Surgeons of Paris," returned to Quebec, carrying with him a King's commission authorizing him to institute a school of barber surgeons. He did not start such a school, and no law existed that physicians, surgeons, apothecaries, or midwives were required to attend any school. However, Madry did train apprentices.<sup>2(p225),3(p16)</sup> Abuses of laissez-faire systems develop inevitably. When they did in New France, the Intendant Bigot responded in 1750 with a bill (<i>L'Acte Medicale du Canada</i>) which Heagerty considers the code of the medical profession
Life-Sustaining Therapies in Elderly Persons
Authors: Peter G. Tuteur
Journal: JAMA (1990)

In a time of concern about limited health care resources, it is reasonable to question the efficacy of their use. Two studies in this issue ofThe Journalfocus on life-sustaining therapies. When is their use appropriate? Longstreth and colleagues<sup>1</sup>look at out-of-hospital cardiopulmonary resuscitation (CPR). They ask: Can the elderly benefit from this procedure? A review of all out-of-hospital cardiac arrests treated by paramedics over a recent 5-year period in Seattle, Wash, reveals that 140 persons (10%) 70 years and older were resuscitated, admitted to a hospital, and discharged alive; of these, 112 went home. From these data, Longstreth et al conclude, "Elderly patients can benefit from attempted resuscitation of out-of-hospital cardiac arrest." Also in this issue, Murphy and Matcher<sup>2</sup>explore a way to understand how life-sustaining therapies benefit patients. In an attempt to be at once critical and objective, they propose a mathematical model that quantifies
Epidemiologic Differences Between Sexual and Physical Child Abuse
Authors: Janine Jason
Journal: JAMA (1982)

Sexual and physical child abuse are assumed to differ; however, these differences have not been well characterized epidemiologically. Furthermore, despite assumed differences, these types of abuse are often analyzed as one entity. This can have significant effects on assessment of risk and recommendations for intervention. We compared 735 cases of sexual abuse and 3,486 cases of nonsexual physical abuse confirmed by the Georgia Department of Protective Services. Sexual and physical child abuse cases differed in age, sex, and relationship of perpetrators and victims; demographic and socioeconomic characteristics of families at risk; and morbidity and mortality caused by the event. The most important recommendation based on these findings is that epidemiologically distinct forms of child abuse must be analyzed separately before intervention measures are proposed. (<i>JAMA</i>1982;247:3344-3348)
Clinical Effectiveness of Anti-motion-Sickness Drugs
Authors: Charles D. Wood
Journal: JAMA (1966)

A computer library of the literature on anti-motionsickness drugs has been established at the Navy Institute of Aerospace Medicine at Pensacola, Fla. The overall effectiveness of the antihistamines was 70.6%; for the belladonnas it was 50.1%, and for the phenothiazines, 44.9%. The overall results of British studies indicated a greater effectiveness for the belladonnas than for the antihistamines, which is the reverse of the results of US studies. In a recent series of studies dextroamphetamine was found to be a highly effective anti-motion-sickness drug with an overall effectiveness of 64%. The drugs were found to be more effective for motion sickness during flight than for motion sickness at sea.
Permanent Implantation of the Jarvik-7 Total Artificial Heart: A Clinical Perspective
Authors: Gerald M. Lawrie
Journal: JAMA (1988)

In this issue ofTHE JOURNAL, DeVries<sup>1</sup>reports the clinical courses of four patients in whom Jarvik-7 total artificial heart (TAH) prostheses were implanted as permanent cardiac substitutes. All four patients subsequently suffered serious complications; despite these, three patients achieved survival with the TAH for intervals of 112, 488, and 620 days. The Jarvik-7 prosthesis is a direct descendant of the early series of pneumatically driven TAH prostheses developed by Willem Kolff, MD, and colleagues working first at The Cleveland Clinic and later at the University of Utah.<sup>2</sup>In February 1963, Michael E. DeBakey, MD, proposed that the federal government support an organized program to develop a TAH.<sup>3</sup>Established at the National Institutes of Health in 1964, the Artificial Heart Program had as its goals the development of a broad spectrum of devices for short-term circulatory and longterm ventricular assistance as well as the development of TAH
Vinblastine Sulfate vs Cyclophosphamide in the Therapy for Lymphoma
Authors: Leon Stutzman
Journal: JAMA (1966)

Vinblastine sulfate therapy and cyclophosphamide therapy were compared in a random fashion in 69 patients with various types of lymphoma in a total of 96 courses of therapy. High initial or "loading" doses were not used and dosage was adjusted at weekly visits according to effect and toxicity. Vinblastine, to which 28 of 33 patients responded, was found to have marked superiority over cyclophosphamide in the control of Hodgkin's disease. However, cyclophosphamide was superior for the therapy of reticulum cell sarcoma and lymphosarcoma, with a response appearing in 12 of 20 patients with these diseases. Toxicity was not a serious problem in these cases. Vinblastine is recommended as the initial chemotherapeutic agent in patients with Hodgkin's disease, unless a prompt response is necessary.