tbuckley/cabot-search huggingface dataset:
Conservative or Surgical Treatment of Genital Tuberculosis in Women?
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PRESIDENT ROOSEVELT ON THE PHYSICIAN.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fat Transport in Lipoproteins — An Integrated Approach to Mechanisms and Disorders
Authors: Donald S. Fredrickson, Robert I. Levy, Robert S. Lees
Journal: New England Journal of Medicine (1967)

Glyceride TransportTwo Forms of Plasma Glyceride TransportIn subjects on fat-free diets the plasma lipid concentrations vary little throughout the day and tend to be highest just before breakfast.102 When the diet contains fat the levels of cholesterol and phospholipids in plasma are still relatively constant, but the glyceride concentration, as already intimated, is quite variable. It is lowest during the early morning hours (when blood samples for analysis are usually taken) and rises sharply, reaching a peak about three hours after breakfast. The concentration is boosted again by the midday meal, and after some decline in the afternoon, . . .
Van Gogh's vision. Digitalis intoxication?
Authors: T. C. Lee
Journal: JAMA (1981)

Vincent van Gogh, the Dutch postimpressionist painter, died in 1890. He was an uncommon man. Automutilation, depression, insanity, and suicide are part of his medical history. During the last few years of his life, his paintings were characterized by halos and the color yellow. Critics have ascribed these aberrations to innumerable causes, including chronic solar injury, glaucoma, and cataracts. Van Gogh may have been under the influence of digitalis intoxication and its side effects: xanthopsia and coronas. This hypothesis is based on his twice having painted his physician holding a foxglove plant; that this medicine was used in the latter part of the 19th century in the treatment of epilepsy; and that the toxic effects of digitalis may have, in part, dictated the artist's technique. (<i>JAMA</i>1981;245:727-729)
Topoisomerase-based chemotherapy in adults with relapsed or refractory pediatric-type sarcoma: A retrospective analysis of the German AIO Sarcoma Group/BMBF SAREZ registry.
Authors: J. T. Hartmann, I. Sturm, R. D. Issels, S. W. Krause, V. Gruenwald, A. Kunitz, L. Lindner, K. San Nicolo, F. Mayer, B. Hertenstein, L. Mueller, U. Kontny, J. Topaly, R. U. Trappe, W. Grothe
Journal: Journal of Clinical Oncology (2011)

10084 Background: The objective was to assess the efficacy and safety of topoisomerase-based (TOPO) regimens in adult patients (pts) with pediatric-type sarcoma who failed induction chemotherapy. Methods: Pts with tumors belonging to the Ewing’s sarcoma family of tumors, osteosarcomas, embryonal and alveolar RMS, synovial or desmoplastic small round cell, refractory or relapsed after at least one prior induction chemotherapy, inoperable, locally advanced or metastatic, with progressive disease and adequate organ functions were treated with TOPO-inhibitor based regimens, consisting of topotecan, irinotecan, or etoposide combined with cyclophosphamide or carboplatin. Results: 45 pts, median age 29 yrs (16-59), 16 female, 29 male, had previously received induction treatment according to (inter)national study protocols. TOPO regimens consisted of topotecan + cyclo (n=36), single-agent irinotecan (2), etoposide + carbo (2) and topotecan + carbo (5), and were applied as 2nd-line treatment in 38 pts and ≥ 3rd-line in 7 pts. 27 pts had refractory disease (evidence of tumor progression within 6 mo of induction chemo); 10 pts had early relapses (6-24 mo) and 8 pts late relapse (> 24 mo). Pts received a median of 3 cycles (range, 1-6). Grade 3-4 CTC toxicity consisted mainly of hematologic side effects as well as nausea/vomiting and fatigue, 1 TRD occurred. Anti-tumor activity (n=43): 2 CR (4.7%), 5 PR (11.6%) and 12 SD (27.9%). Median duration of CR/PR/SD was 759d (1061-1362)/ 381 (100-1785)/160 (61-468), respectively. Pts with refractory disease had a lower chance to attain a response (CR/PR/SD) to treatment (p=0.001). The 3/6-mos PFR were 42% and 23% for all pts; however, 16% of pts achieved survival ≥ 24 mo. Factors associated with improved survival were response to treatment (2 CR) and PR + secondary surgery. Conclusions: The TOPO regimens with proven activity in pediatric pts show moderate effectivity in our adult pts with refractory or relapsed pediatric-type sarcoma. Adults with refractory small cell sarcoma appear to have a similar dismal outcome as pts with common adult-type histology, even though a subset of pts did achieve prolonged survival.
Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen
Authors: D LASKIN
Journal: Hepatology (1995)

Acetaminophen is a mild analgesic and antipyretic agent that is safe and effective when taken in therapeutic doses. Ingestion of overdoses, however, may lead to acute liver failure accompanied by centrilobular degeneration and necrosis. Although the toxicity of acetaminophen is generally thought to be caused by direct interaction of its reactive metabolites with cellular macromolecules, recent studies have suggested that nonparenchymal cells also may contribute to tissue injury indirectly through the release of cytotoxic mediators. We analyzed the potential role of hepatic macrophages in acetaminophen hepatotoxicity by examining the effects of modulating the activity of these cells on tissue injury. Treatment of male Long Evans Hooded rats with acetaminophen (800 mg/kg) was found to induce extensive centrilobular hepatic necrosis. Pretreatment of the rats with either dextran sulfate or gadolinium chloride, two inhibitors of hepatic macrophage functioning, completely blocked hepatic necrosis, as well as increases in serum transaminase levels induced by acetaminophen. Interestingly, treatment of rats with the macrophage activator, lipopolysaccharide (LPS), also reduced tissue injury induced by acetaminophen. To exclude the possibility that the effects of gadolinium chloride, dextran sulfate, or LPS were due to alterations in acetaminophen metabolism, we analyzed the effects of these agents on various pharmacokinetic properties of this analgesic. Dextran sulfate and gadolinium chloride had no effect on the half-life of a low dose of acetaminophen (20 mg/kg), or on the activity of any of its individual pathways of metabolism, including the formation of acetaminophenmercapturic acid. LPS treatment of rats caused a general depression of acetaminophen metabolism involving all of the known pathways of metabolic clearance, resulting in a decrease in the blood half-life of the drug. However, the fraction of the dose converted to the toxic metabolite (NAPQI) was not different from that observed in rats given acetaminophen alone. Collectively, these data indicate that the protection afforded the animals by pretreatment with macrophage modulators was not due to suppression of the formation of NAPQI and hence support the hypothesis that macrophages may contribute directly to acetaminophen hepatotoxicity by an independent mechanism. (HEPATOLOGY 1995; 21:1045–1050.)
MUNC-ing around with insulin action
Authors: David E. James
Journal: Journal of Clinical Investigation (2005)

Defective uptake of glucose into muscle and fat cells, or insulin resistance, is a central feature of obesity and type 2 diabetes. As we brace ourselves for the diabetes epidemic, it is reassuring to know that real progress is being made in defining the molecular biology of how insulin stimulates glucose uptake and what goes awry in obesity and type 2 diabetes. An understanding of the molecular determinants of insulin-stimulated glucose transport has been one of the holy grails of hormone action research. A major breakthrough was the discovery that insulin stimulates the translocation of a specific glucose transport protein, GLUT4, from intracellular vesicles to the cell surface. Elucidating how this process is regulated has remained a challenge because it represents a convergence of 2 disparate and complex fields of research — namely, vesicle transport and signal transduction. A study reported in this issue of the JCI using mice lacking Munc18c, one of the vesicle-trafficking proteins involved in GLUT4 translocation, has provided new insights into the signaling/trafficking intersection that controls insulin-stimulated GLUT4 movement.
Veterinary Hygiene.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Self-Energizing Cardiac Pacemaker
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physical Examination of the Abdomen in Health and Disease. Part II
Authors: C. J. B. Williams
Journal: BMJ (1851)

THrx method of Palpation of the Abdomen is a subject of importance, and demands a few directions and cautions.The parts of the hands best qualified to feel are the palmar surfaces of the fingers, the pulpy portions of the last phalanx being endowed with the finest touch.But they should be flatly applied, at least at first; as nothing is more likely to start the abdominal muscles into rigid contraction than to poke them abruptly with the ends of the fingers.For the same reason, the observer should not be too much above the patient, and if the bed on which the patient is placed is low, the practitioner should sit or kneel beside it, in order to bring his arms and hands more on a level with the abdomen.It is equally obvious that the observer's hands should be comfortably warm; not only for the sake of the patient, but also be- cause the touch is more sensitive in that condition.The posture of the patient generally best suited for examination is the supine, on a mattress or sofa, with the limbs lying straight, but without the least straining or muscular effort.It is often recommended to draw up the knees in order to relax the abdominal muscles; but this action is very apt to produce just the contrary effect, and further interferes with the free accessibility of the lower parts of the abdomen to the observer's hands.It is the great object, that whilst the body and limbs are so equally and completely supported as to be in a state of perfect relaxa- tion, the whole abdomen shall freely admit of the application of the hands to every part, and in every direction.This further suggests, that in all cases requiring nicety in manipulation, the abdomen should be laid bare, the clothing sufficiently put out of the way, and that citlher the bed be narrow enough or the patient be moved to each VOL.III.
Chiropractic causes leak of CSF
Journal: BMJ (2003)

Fibroid embolisationBilateral uterine artery embolisation (fibroid embolisation) is a new technique that has gained some favour in the treatment of fibroids.However, relatively few successful pregnancies have been reported, and there is a risk of hysterectomy because of sepsis of necrotic fibroids.The joint report of the Royal College of Obstetricians and Gynaecologists and the Royal College of Radiologists does not recommend fibroid embolisation for infertile women until more is known about outcome. 7 Fibroids and in vitro fertilisationIn women about to begin a course of in vitro fertilisation treatment, there is evidence that intramural fibroids reduce the chance of treatment success because they decrease the implantation potential of an embryo.Evidence also exists that the incidence of miscarriage may be increased in women with an intramural fibroid having in vitro fertilisation treatment.However, no randomised trials show whether myomectomy done on these women will increase their chances of conception.
Amer J of Roentgenology, Springfield, Ill
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Some guiding principles for clinical investigation
Authors: H. K. Beecher
Journal: JAMA (1966)

Human experimentation takes place in several areas: in normal volunteers, in self-experimentation, in patient volunteers, in patients requiring therapy, in experimentation on patients not for their direct good but for the welfare of patients in general. There are ethical problems in all of these categories. The most difficult ones appear in the last area mentioned, and it will be considered first, for in large part guides there also apply to the less difficult areas. <h3>Experimentation for the Benefit of Others, Not for the Patient Involved</h3> Rigid codes which attempt to give detailed instructions to govern research are to be avoided. It is not possible to outline all contingencies; the consequent shortcomings when revealed during work invite legal action. Insofar as it is possible, it is essential to get the informed consent of the patient involved prior to study. It must be recognized that in any complete sense this often is
Congenital Aortic Stenosis. A Series of Surgical Corrections
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PURULENT OPHTHALMIA FROM THE STANDPOINT OF ITS SPECIFIC MICROBIO CAUSE;WITH A PLEA FOR A MORE ENERGETIC, RATIONAL, ABORTIVE TREATMENT WHERE POSSIBLE. Read before the Section on Ophthalmology, at the Forty-fourth Annual Meeting of the American Medical Association at Milwaukee.
Authors: ALFRED HINDE
Journal: JAMA (1893)

(<i>Concluded from page 564</i>.) Mauriac decides that "the abortive treatment is indicated and has some chances of succeeding in acute gonorrhea only during the first hours of its outset." Diday believes: "That in the early stage every gonorrhea can be aborted," and "that the abortive treatment is neither locally nor constitutionally dangerous." Two methods may be followed: a strong solution may be used for a short time in the urethra or a weaker solution may be left in contact for a longer time. A 5 per cent. solution of nitrate of silver is allowed to remain in the urethra from forty to ninety seconds, according to the pain produced. A free discharge occurs after two days, and as a result of the burning may continue for four days and then gradually ceases in a few days more. The abortive treatment is considered worthy of trial in view of the serious
Abstract 1461: BLADE Is A Novel Membrane Protein That Regulates Endothelial Apoptosis and Consequently Angiogenesis Both In Vitro and In Vivo
Authors: Koji Ikeda, Ritsuko Nakano, Thomas Quertermous, Hiroaki Matsubara
Journal: Circulation (2007)

Endothelial apoptosis is a pivotal process for angiogenesis during embryogenesis as well as postnatal. Here, we identified a novel gene, termed BLADE, that regulates endothelial apoptosis and consequently angiogenesis. BLADE was highly expressed in a variety of human cultured endothelial cells such as endothelial cells from umbilical vein (HUVEC), aorta, coronary artery and microvessels while no expression was observed in non-endothelial cells including HeLa cell, hepatoma cell and vascular smooth muscle cells. Furthermore, BLADE was expressed predominantly in blood vessels during embryogenesis, suggesting its role in angiogenesis. Amino acid sequence analysis revealed that BLADE was a novel membrane protein with no conserved domain reported before. BLADE expression was altered by treatment with VEGF, TNF-alpha and TGF-beta in HUVEC. Knockdown of BLADE in HUVEC using short interference RNA resulted in significant reduction of endothelial apoptosis. In contrast, BLADE knockdown affected neither endothelial cell migration nor proliferation. Among factors associated with apoptosis, Bcl-2 expression was drastically increased in HUVEC by BLADE-knockdown. Further analysis revealed that this increase of Bcl-2 is due to reduced ubiquitination and less subsequent degradation of Bcl-2. Inhibition of Bcl-2 completely abolished the anti-apoptotic effect of BLADE-knockdown. In vitro tube-formation of HUVEC on Matrigel was reduced concomitantly with reduced apoptosis by BLADE-knockdown at early time (12h). Nevertheless, significantly more tubes were preserved at late time (96h) by BLADE-knockdown. Moreover, in vivo angiogenesis assessed by Matrigel-plug was dramatically enhanced by BLADE-knockdown. Taken together, BLADE is a novel factor regulating endothelial apoptosis as well as angiogenesis both in vitro and in vivo. Detailed analysis of BLADE will provide new insights in the regulation of endothelial apoptosis, and in the molecular link between endothelial apoptosis and angiogenesis. Because BLADE is highly preferentially expressed in endothelial cells, inhibition of BLADE might be an ideal approach to enhance endothelial cell survival and angiogenesis without affecting the survival of other type of cells.