tbuckley/cabot-search huggingface dataset:
A phase I/II study of the investigational drug alisertib in combination with abiraterone and prednisone (AP) for patients with metastatic castration-resistant prostate cancer (mCRPC) progressing on abiraterone.
Authors: Jianqing Lin, Ashwin Reddy Sama, Jean H. Hoffman-Censits, Deborah Kilpatrick, Hushan Yang, Zhaomei Mu, Benjamin E Leiby, Nancy Lewis, Massimo Cristofanilli, William Kevin Kelly
Journal: Journal of Clinical Oncology (2014)

TPS5107 Background: Aurora A kinase (AK) over-expression is found in 98% prostate cancer (PCa) lesions. Its level is associated with Gleason score, Ki-67 expression, preoperative PSA and pathological staging. AK phosphorylates and interacts with androgen receptor (AR) and enhances AR DNA binding activity and potentiates androgen action in AR. Targeting AK could suppress tumour growth and enhances chemosensitivity in both AR positive and negative in vitro. We hypothesized that AK contributes to castration resistance in PCa and targeting AK can inhibit AR function and re-sensitize PCa cell to castration. Methods: This is a phase I/II, open label, single institution trial to determine the safe dose of the investigational AK inhibitor alisertib when given in combination with AP. Patients with mCRPC and disease progression by PCWG 2 criteria while on AP will be eligible. AP will be continued during the study and alisertib will be added to AP regimen. In phase I, standard 3+3 design with 3 dose cohorts (alisertib 30, 40, 50 mg PO BID days 1-7 every 21 days) will be carried out to determine RP2D of alisertib when given in combination with AP. The safety and toxicity profile will be examined. Data analysis of phase I studies is descriptive. Cohort 2 is currently enrolling. The primary endpoint of the phase II expansion is to determine the proportion of patients without disease progression after alisertib is added to AP, using Minimax Simon two-stage design. The study will analyze the effects of alisertib on PSA kinetics; changes in circulating tumor cells (CTCs) and serum neuroendocrine marker (chromogranin A and NSE) levels. CTCs will also be isolated to determine AK amplification. Clinical trial information: NCT01848067.
Blue
Authors: S Keitz
Journal: Annals of Internal Medicine (1998)

On Being a Patient1 November 1998BlueSheri Keitz, MD, PhDSheri Keitz, MD, PhDDurham, NC 27705Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-9-199811010-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Mommy, look-your hand is all blue. Why is it like that?”“It just got a bit hurt when I was in the hospital. It's nothing.”5 a.m. The pump beeped. The digital display blinked “distal occlusion.” In the dark, I felt the tubing and searched for kinks. I turned on the light above the bed and looked for air bubbles. The IV was brand new, not 8 hours old. It couldn't be infiltrated. It just couldn't be. I rang for the nurse.“My pump is beeping.”She came in and tried to fix it; there were no kinks, no air ... Author, Article, and Disclosure InformationAffiliations: Durham, NC 27705Corresponding Author: Sheri Keitz, MD, PhD, Ambulatory Care Service (IIC), Durham Veterans Affairs Medical Center, 508 Fulton Street, Durham, NC 27705. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1998Volume 129, Issue 9Page: 744-745KeywordsBreathingChartsColonColonoscopyFallsHoneyNursesSteroidsTechniciansVeins Issue Published: 1 November 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
PRAGUE
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bevacizumab Fails to Up Breast Cancer Survival
Journal: Cancer Discovery (2012)

Abstract Bevacizumab (Avastin; Genentech) did not produce statistically significant improvements in survival in 2 randomized phase III clinical trials, one for patients with triple-negative breast cancer and one for patients with HER2-negative, HR-positive breast cancers, reported at the San Antonio Breast Cancer Symposium.
Critical elements in the diagnosis of alcoholism. A national survey of physicians
Authors: W. J. Filstead
Journal: JAMA (1976)

IT IS generally recognized that prolonged and excessive consumption of alcohol can have a deleterious effect on a person's physical health and psychosocial functioning. Yet, for a long time, there were no clearly identifiable criteria to diagnose alcoholism and to determine the extent and scope of any particular drinking pattern.<sup>1-6</sup> In an attempt to deal with this problem, the National Council on Alcoholism (NCA) established a criteria committee composed of prominent professionals in the field of alcoholism to define criteria for the diagnosis of alcoholism. The committee used as models diagnostic classifications developed in other areas of medicine<sup>7-11</sup>and also evaluated specific criteria used by alcoholism investigators.<sup>12</sup>The initial draft was sent to professionals in the alcoholism field for their comments and suggestions. The final draft consisted of two sets or tracks of criteria: Track 1 contains physiological and clinical items; track 2, behavioral, psychological, and attitudinal
Arch Biochemistry and Biophysics, New York
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ANIMAL DRUG TERATOGENICITY: ITS APPLICATION TO MAN
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiovascular and renal effects of long-term antihypertensive treatment
Authors: M Hartford, I Wendelhag, G Berglund, I Wallentin, S Ljungman, J Wikstrand
Journal: JAMA (1988)

To study whether restoration of a normal circulatory system could be achieved with antihypertensive treatment, 13 hypertensive men with structural cardiovascular changes and 37 normotensive control subjects were investigated by echocardiography, apexcardiography, plethysmography, inulin and p-amino-hippurate clearance, and determination of 24-hour urinary excretion of albumin, first at age 49 years and again seven years later. All men were untreated at the first investigation. Immediately thereafter, therapy with the cardioselective beta-adrenoceptor blocker metoprolol tartrate was initiated in the hypertensive men. Seven years of antihypertensive treatment resulted in (1) normalization of central and peripheral hemodynamic variables, (2) reversal of left ventricular hypertrophy in proportion to achieved blood pressure control, (3) normalization of systolic wall stress and a well-preserved systolic left ventricular function, (4) normalization of diastolic left ventricular function, and (5) normalization of increased microalbuminuria and a decrease in renal vascular resistance, with no change in glomerular filtration rate compared with control subjects. In conclusion, the findings strongly indicate that regression of cardiovascular structural changes can be achieved with long-term antihypertensive treatment.
Health status of Vietnam veterans. III. Reproductive outcomes and child health. The Centers for Disease Control Vietnam Experience Study
Authors: Eugenia E. Calle, Muin J. Khoury, Linda A. Moyer, Coleen A. Boyle, M. Riduan Joesoef, Robert J. Delaney, Elizabeth A. Cochran, Patricia Holmgreen, Martha I. Hunter, Terryl J. Meranda, Mark J. Scally, Robert M. Worth, Charles L. Adams, Joseph L. Annest, Drue H. Barrett, Andrew L. Baughman, Edward A. Brann, Karen S. Colberg, Pierre Decoufle, Frank DeStefano, Owen J. Devine, Robert C. Diefenbach, Barbara Dougherty, Sandra S. Emrich, W. Dana Flanders, Anthony S. Fowler, Robert R. German, John M. Karon, Marcie-jo Kresnow, Heather D. McAdoo, Brenda R. Mitchell, Robin D. Morris, Thomas R. O'Brien, Joseph B. Smith, Nancy E. Stroup, Scott F. Wetterhall, John J. Drescher, J. David Erickson, Melinda L. Flock, John J Gallagher, Jerry G. Gentry, Marilyn L. Kirk, Michael E. Kafrissen, Peter M. Layde, Maurice E. LeVois, Peter McCumiskey, Daniel L. McGee, Daniel A. Pollock, Melvin W. Ralston, Philip H. Rhodes, Richard K. Rudy, Paul D. Simpson, Dennis M. Smith
Journal: JAMA (1988)

The Vietnam Experience Study was a multidimensional assessment of the health of Vietnam veterans. From a random sample of enlisted men who entered the US Army from 1965 through 1971, 7924 Vietnam and 7364 non-Vietnam veterans participated in a telephone interview; a random subsample of 2490 Vietnam and 1972 non-Vietnam veterans also underwent a comprehensive medical examination. During the telephone interview, Vietnam veterans reported more adverse reproductive and child health outcomes than did non-Vietnam veterans. However, children of Vietnam veterans were not more likely to have birth defects recorded on hospital birth records than were children of non-Vietnam veterans. The rates of total, major, minor, and suspected defects were similar among children of Vietnam and non-Vietnam veterans (odds ratios, 1.0, 1.1, 1.0, and 0.9, respectively). These results are consistent with the findings of three epidemiologic studies conducted since 1981 on the relationship of Vietnam service and birth defects in children of male veterans.
Thrombin-Activated Human Endothelial Cells Support Monocyte Adhesion In Vitro Following Expression of Intercellular Adhesion Molecule-1 (ICAM-1; CD54) and Vascular Cell Adhesion Molecule-1 (VCAM-1; CD106)
Authors: Gilles Kaplanski, Valérie Marin, Martine Fabrigoule, Vera Boulay, Anne-Marie Benoliel, Pierre Bongrand, Solange Kaplanski, Catherine Farnarier
Journal: Blood (1998)
Clinical Infertility in Women
Authors: Griff T. Ross
Journal: Environmental Health Perspectives (1978)

Fertility results from coordinate functioning of components of the hypothalamic-pituitary-ovarian-genital axis. In normal women, ovarian sex steroid hormones act as the mediators of these interactions. Infertility is a clinical manifestation of the failure of one or more of the components to function appropriately. Determining the locus of dysfunction provides the basis for rational treatment. For these purposes, both direct measurement of serum hormone levels and assessments of target organ function are utilized.
地高辛联合呋塞米对于皮肤疣有效
Authors: M. Rijsbergen, T. Niemeyer‐van der Kolk, G. Hogendoorn, S. Kouwenhoven, C. Lemoine, E.S. Klaassen, M. Koning, S. Beck, J.N. Bouwes Bavinck, G. Feiss, J. Burggraaf, R. Rissmann
Journal: British Journal of Dermatology (2019)

这是一项研究两种局部外用(即用于皮肤)药物‐地高辛和呋塞米对于治愈皮肤病毒疣的影响。该研究由荷兰和美国宾夕法尼亚的一个小组实施。已知这项研究是一项概念验证研究,是证实一种特定治疗过程是否可能有益的初步实验。因为这两种药物可以阻止钾进入细胞(疣病毒在人皮肤中存活的必须过程),认为这两种药物可以改善病毒疣的治愈率。该小组使用了同时含这两种药物的一种局部外用制剂,并测量了疣的尺寸、它们表面可见特征的存在情况和它们的消失;另外还采集样本检测病毒疣的存在情况。所有患者均存在对其他治疗无反应的病毒疣。在研究中对接受这两种药物联合、每种单独使用或安慰剂治疗的不同组患者(每组 20 名)进行了随访。结果显示,在每天治疗 6 周和 14 周随访期后,只有接受地高辛和呋塞米联合治疗的患者显示改善,其中一些实现了疣的清除。这一结果令人鼓舞,但应在更多数量的之前未接受过治疗的病毒疣患者中进行研究,因为尽管这一新的治疗带来了较大的改善,但病毒疣完全消失的患者数量少。没有与此治疗相关的副作用。
Multi-institutional phase II study of high dose, hypofractionated proton beam therapy (HF-PBT) for unresectable primary liver cancers: Long term outcomes in patients (pts) with intrahepatic cholangiocarcinoma (ICC).
Authors: Theodore S. Hong, Jennifer Yon-Li Wo, Beow Y. Yeap, Edgar Ben-Josef, Erin I McDonnell, Lorraine C. Drapek, Lawrence Scott Blaszkowsky, Eunice Lee Kwak, Jeffrey W. Clark, Lipika Goyal, David P. Ryan, Milind M. Javle, John A. Wolfgang, Ronald Arellano, John Thomas Mullen, Cristina Ferrone, Kenneth Tanabe, Thomas F. DeLaney, Christopher H. Crane, Andrew X. Zhu
Journal: Journal of Clinical Oncology (2015)

4020 Background: Modern radiotherapy (RT) techniques such as protons permit delivery of ablative doses of RT to the liver. Prior reports of PBT in hepatocellular carcinoma (HCC) demonstrate local control (LC) rates exceeding 85% but outcomes with high dose RT in pts with ICC remain lacking. We report on clinical outcomes of high dose, HF-PBT in pts with unresectable ICC. Methods: Pts enrolled on an NCI sponsored, multi-institutional, phase II study (NCT00976898). Key eligibility were HCC or ICC, unresectable by multidisciplinary review, Child’s A/B, ECOG PS 0-2, no extrahepatic disease, no prior RT. Maximum tumor size was 12 cm if solitary, 10 cm if 2 tumors, and 6 cm if 3. PBT was given in 15 fractions to a maximum total dose of 67.5 GyE. Sample size was calculated to demonstrate > 80% LC at 2 yrs for HCC pts with acceptable precision for estimating outcomes for ICC. Results: From 2009-2014, 93 pts were enrolled, of whom 90 were evaluable. 41 pts had ICC, 2 pts had mixed HCC/ICC, and 47 pts had HCC (reported separately). In this ICC specific-analysis (n = 43), median age was 67 (range 29-87), 16 (37%) were male. 36 (84%) and 5 (12%) pts had Child-Pugh A and B cirrhosis, respectively. 2 (4%) pts had no cirrhosis. 25 (58%) pts had prior systemic therapy. 25 (58%) pts had prior systemic therapy. 39 pts(90.6%) had 1 tumor, 2 pts (4.7%) had 2 , 2 pts (4.7%) had 3 . Median tumor size was 6.0 cm (range 2.2-10.9). Median RT dose received was 58 GyE (range 15.1-67.5). 6 (14%) pts developed Gr 3 RT-related toxicity, including thrombocytopenia (2), hyperbilirubinemia (2), gastric ulcer (1), pain (1), elevated LFTs (1), and liver failure/ascites (1). With a median follow up of 13 months (range 5d–51 mo) among 22 pts still alive, the 2 year LC was 96%. mOS was 21 months (95% CI 13-29) and mPFS was 9 months (95% CI 6-24). When excluding Child’s B (N = 38), mOS was 23 months (95% CI 15-49) and mPFS was 10 months (95% CI 5-24); 2 yr OS rate was 48% and 2 yr PFS rate was 38%. Conclusions: High dose PBT for ICC results in high rates of LC and OS. This data forms the basis for the ongoing NRG GI-001 study, a randomized trial of gem/cis +/- hypofractionated RT. Support: NCI # P01CA2123 Clinical trial information: NCT00976898.
Music not only has charms to soothe, but also to aid elderly in coping with various disabilities
Authors: T. Randall
Journal: JAMA (1991)

ALTHOUGH illnesses vary, very patient at the geriatric day hospital at The University of Texas Medical Branch (UTMB), Galveston, receives one therapy in common. This therapy is unusual in that it elicits immediate and positive effects in nearly all who receive it and has virtually no contraindications. Furthermore, it costs little more than a song because it is precisely that: a song. "I'm in heaven when we're dancing cheek to cheek," Louis Armstrong and Ella Fitzgerald croon. As the tune emanates from the music therapist's portable tape player, 20 geriatric patients seated in two large circles reach out to pat their neighbors' shoulders, look in each others' eyes, and smile. <h3>Music for Mobility, Analgesia</h3> In what is probably the highlight of their day at this specialized facility (one of only a handful of geriatric day hospitals in the United States [see accompanying article]) these patients are about to begin a
Epidemiologic study design for investigating respiratory health effects of complex air pollution mixtures.
Authors: D W Dockery
Journal: Environmental Health Perspectives (1993)

Epidemiologic studies of the respiratory health effects of air pollution are intrinsically difficult because exposure is common, expected effects at concentrations found in developed countries are weak, random misclassification of exposure is common, and the respiratory health indicators have multiple etiologies. Exposures to air pollutants also are multidimensional, generally consisting of a mixture of gases and particles. In this paper, epidemiologic study designs are described, and their potential for evaluating effects of complex pollutant mixtures are discussed. Power to detect the independent effects of individual pollutants in a complex pollutant mixture or to measure their interactions is in general very weak unless the study is specifically designed to test such hypotheses. However, with innovative and creative design, the independent and joint effects of multiple pollutants should be estimable in epidemiologic studies.
Transfusion management of an IgA deficient patient with anti‐IgA and incidental correction of IgA deficiency after allogeneic bone marrow transplantation
Authors: R.L. Rogers, T.A. Javed, R.E. Ross, G. Virella, R.K. Stuart, D. Frei‐Lahr
Journal: American Journal of Hematology (1998)

A patient with multiple myeloma was noted to have an IgA deficiency during investigation of a possible transfusion reaction due to IgA deficiency and anti-IgA. Because of the patient's age, otherwise good health, and early stage of disease, he was enrolled in a research treatment protocol that involved an allogeneic bone marrow transplant (BMT). The BMT successfully put the patient in complete remission from his multiple myeloma and corrected his IgA deficiency. Class-specific IgG anti-IgA antibody that had been identified prior to BMT was no longer detectable in his plasma. Anaphylactic transfusion reactions were successfully avoided by using a combination of IgA-deficient and washed blood components including the marrow graft, and IgA-reduced intravenous immunoglobulin. Am. J. Hematol. 57:326–330, 1998. © 1998 Wiley-Liss, Inc.
Epidemic Occurrence of Infectious Mononucleosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer, New York
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal