tbuckley/cabot-search huggingface dataset:
Hemochromatosis, multiorgan hemosiderosis, and coronary artery disease
Authors: M. Miller
Journal: JAMA (1994)

<h3>Objective.</h3> —To examine the prevalence of coronary artery disease (CAD) in autopsies of patients with iron-overload syndromes. <h3>Design.</h3> —Retrospective autopsy study of CAD in cases of hemochromatosis and multiorgan hemosiderosis. <h3>Setting.</h3> —Registry of nearly 48000 autopsies performed at The Johns Hopkins Hospital between 1889 and 1992. <h3>Subjects.</h3> —One hundred twenty-three subjects were studied. In a 2:1 control-case ratio, 82 controls matched by age, race, and sex were compared with 41 cases with iron overload. <h3>Main Outcome Measure.</h3> —Severity of CAD. <h3>Results.</h3> —Pathological description of the coronary arteries were recorded as advanced or severe in 12% of iron-overload cases(n=41) (mean age, 57.6±13.2 years) compared with 38% of controls (n=82) (mean age, 57.0±13.8 years) (<i>P</i>=.01). The prevalence of three-vessel disease assessed by postmortem coronary arteriography was 11.1% in iron-overload cases (n=18) (mean age, 61.7±12.2 years) compared with 33.3% in controls (n=36) (mean age, 61.1±12.5 years) (<i>P</i>=.04). The odds ratio of CAD with iron overload was 0.18 (95% confidence interval, 0.04 to 0.73). <h3>Conclusions.</h3> —Iron overload resulting from hemochromatosis or multiorgan hemosiderosis is not associated with an increased prevalence of CAD. (<i>JAMA</i>. 1994;272:231-233)
A comparison of verapamil and propranolol for the initial treatment of hypertension. Racial differences in response
Authors: L. X. Cubeddu
Journal: JAMA (1986)

We compared verapamil and propranolol hydrochloride for monotherapy of hypertension. Verapamil lowered blood pressure (BP) more effectively than propranolol in black and white patients. Verapamil was equally effective in blacks and whites, whereas propranolol was more effective in whites. Heart rate was reduced by 6.0 beats per minute by verapamil, and by 13.6 beats per minute by propranolol. In blacks, verapamil lowered systolic BP 16.9 vs 8.1 mm Hg for propranolol; verapamil reduced diastolic BP 12.8 vs 8.6 mm Hg for propranolol. In whites, verapamil lowered systolic BP 19.0 vs 12.7 mm Hg for propranolol; verapamil reduced diastolic BP 16.7 vs 12.3 mm Hg for propranolol. Increases in systolic BP were observed in 22% and 3.4% of patients receiving propranolol and verapamil, respectively. The PR interval was increased from 163.5 to 174.9 ms for verapamil vs 160.3 to 164.4 ms for propranolol. Constipation (15%) and headaches (10%) were most frequent complaints for verapamil vs fatigue (18%) and dizziness (7%) for propranolol. Changes in blood biochemistry values were of small magnitude. We conclude that verapamil monotherapy is a safe and effective means of achieving BP control in patients with essential hypertension. (<i>JAMA</i>1986;256:2214-2221)
Relationship of Variations in the Circle of Willis to Collateral Circulation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Functional esophageal disorders
Authors: R E Clouse, J E Richter, R C Heading, J Janssens, J A Wilson
Journal: Gut (1999)

The functional esophageal disorders include globus, rumination syndrome, and symptoms that typify esophageal diseases (chest pain, heartburn, and dysphagia). Factors responsible for symptom production are poorly understood. The criteria for diagnosis rest not only on compatible symptoms but also on exclusion of structural and metabolic disorders that might mimic the functional disorders. Additionally, a functional diagnosis is precluded by the presence of a pathology-based motor disorder or pathological reflux, defined by evidence of reflux esophagitis or abnormal acid exposure time during ambulatory esophageal pH monitoring. Management is largely empirical, although efficacy of psychopharmacological agents and psychological or behavioral approaches has been established for serveral of the functional esophageal disorders. As gastroesophageal reflux disease overlaps in presentation with most of these disorders and because symptoms are at least partially provoked by acid reflux events in many patients, antireflux therapy also plays an important role both in diagnosis and management. Further understanding of the fundamental mechanisms responsible for symptoms is a priority for future research efforts, as is the consideration of treatment outcome in a broader sense than reduction in esophageal symptoms alone. Likewise, the value of inclusive rather than restrictive diagnostic criteria that encompass other gastrointestinal and non-gastrointestinal symptoms should be examined to improve the accuracy of symptom-based criteria and reduce the dependence on objective testing.
Leads from the MMWR. Influenza surveillance summary--United States, 1982-1983 season
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medicine and South Africa
Authors: R D Le Roex, C E M Viljoen
Journal: BMJ (1986)

SIR,-The president of the Hospital Consultants and Specialists Association states (18 January, p 206) that his association "was very surprised to read the evidenqe of the Short select, committee given by the spokesmen for the medical profession, including the consultant representative on, the BMA delegation, and felt obliged to conduct a survey to.find out if there had been a change of attitude to the hospital staffing structure."As'the "consultant representative" referred to above, I should like to put the-record straight.In 1982 the Central Committee for Hospital Medical Services supported the concept of a controlled.expansion of consultants in general surgery, general medicine, and obstetrics and gynaecology; a reduction in the number of UK graduate registrars in these specilties; and the introduction of an overseas doctors training scheme.These proposals were put to the con- sultant body t large, and 85% of the m,any respondents supported these proposals.This information was included in the select conputtee's *minutes of evidence for Wednesday 27 March 1985, to which the president of the HCSA referred in his letter.Indeed, it states quite clearly i'n those minutes (p 6, paragraph 16) that " HC:MS did not support the Social Servies Committee's geieral notion of a consultant provided service."-In oral evidence used the-phrase "consultant based," and from the subsequent paragraphs itis clear that I was using the phrase.todescribe the proposals tharhad been accepted by the profession in 1982.This includes an adequate numnber of
PERIORAL DERMATITIS
Authors: IAN SNEDDON
Journal: British Journal of Dermatology (1972)

Seventy-three patients, 5 men and 68 women, suffering from perioral dermatitis have been seen in the last 2 years in the Rupert Hallam Department of Dermatology, Sheffield. All but 2 had used fluorinated steroids during the course of their illness. Substitution of hydrocortisone for the fluorinated steroid was followed by improvement in some, but the majority of patients required a course of oxytetracycline 250 mg twice daily for several months to produce complete recovery. A postal follow-up of 20 patients who had discontinued treatment for 6–14 months gave 13 useful replies. Eleven patients had had no further skin eruption, one a mild recurrence, and one who had used betamethasone cream again, a severe recurrence. It is suggested that fluorinated steroid applications can alter banal skin inflammation of the face into perioral dermatitis and that such applications are contraindicated in the treatment of facial eruptions.
Anorexia and Bulimia
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEW
Journal: Allergy (1974)

Book review in this article: ALLERGOLOGY. Proceedings of the VIII International Congress of Allergology. Tokyo, October 14–20, 1973. Edited by Y. Yamamura, O. L. Frick, Y. Horiuchi, S. Kishimoto, T. Miyamoto, P. Naranjo &amp; A. de Week. Excerpta Medico, Amsterdam, 1974.
Shigellosis
Authors: Jack B. Weissman
Journal: JAMA (1974)

OPINIONS differ on the most appropriate course of therapy for shigellosis because of conflicting evidence in the literature concerning the efficacy and possible hazards of specific antibiotic therapy. Proponents of specific chemotherapy note that the efficacy of antimicrobial agents in shigellosis is well established.<sup>1</sup>Moreover, several studies have shown that antibiotics will notably decrease the excretion of shigellae in the stools and abbreviate the clinical course of both mild and severe disease.<sup>2,3</sup>Those opposed to specific therapy except in certain special cases argue that the disease is self-limited and usually mild, that strains have repeatedly emerged resistant to whatever antibiotic happened to be in vogue at the time, and that this resistance has frequently been R factor-mediated, resulting in organisms resistant to multiple antibiotics. These viewpoints have recently been summarized.<sup>4</sup> The clinician responsible for deciding whether to prescribe or withhold antimicrobial therapy in an individual case
SCLEREMA NEONATORUM
Authors: E. DAVIS, R. T. BRAIN
Journal: British Journal of Dermatology (1947)

Journal Article SCLEREMA NEONATORUM Get access E. DAVIS, M.D., M.Sc, Manchester, M.R.C.P., E. DAVIS, M.D., M.Sc, Manchester, M.R.C.P. Late Deputy Medical Superintendent, and Physician to St. Andrews L.C.C. Hospital, Bromley‐by‐Bow Search for other works by this author on: Oxford Academic Google Scholar R. T. BRAIN, M.D., F.R.C.P R. T. BRAIN, M.D., F.R.C.P Late Deputy Medical Superintendent, and Physician to St. Andrews L.C.C. Hospital, Bromley‐by‐Bow Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 59, Issue 8-9, 1 August 1947, Pages 312–314, https://doi.org/10.1111/j.1365-2133.1947.tb10912.x Published: 01 August 1947
Occupational health programs for house staff physicians. Preemployment medical examination
Authors: R. M. Lewy
Journal: JAMA (1981)

THE ROUTINE preplacement examination serves several purposes. First, it identifies illness or disability that might prevent performance of an assigned job function. Second, it provides baseline medical information that can be used as a standard in the event of subsequent injury or illness. Third, it identifies for the individual previously unrecognized or inadequately managed health problems. Although the preplacement examination may be relatively standard from industry to industry, the type of work and the particular work environment will alter the emphasis of the examination. The preplacement examination for hospital workers must pay special attention to the presence of or susceptibility to communicable diseases. Hospitalized patients, particularly those who are immunosuppressed, need to be protected from certain infectious diseases. Hospital workers themselves are subject to a relatively high risk of occupational exposure to infectious disease. A review of 3,599 prospective hospital workers disclosed that most significant observations in the preplacement examination
Continuing education courses for physicians
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quinidine-digoxin interaction
Authors: D. S. Rich
Journal: JAMA (1979)

<h3>To the Editor.—</h3> In March 1979, a nurse was tried by a jury for the murder of a patient in a Maryland hospital.<sup>1</sup>She was accused of deliberately killing this comatose patient by unplugging his respirator. A state forensic pathologist testified that there was no gross evidence of a "respirator brain," a term synonymous with brain death. A forensic pathologist called by the defense said the man was probably brain dead at time of respirator turn-off. An internist testified for the prosecution that the man was alive at time of respirator turn-off. But another internist called by the defense testified that the patient was dead before disconnection of the respirator. The jury was deadlocked after two days of deliberation. The judge then dismissed the jury and declared a mistrial. The prosecutor has decided not to retry the nurse. One week after the mistrial, I interviewed 11 of the 12
17β-Estradiol inhibits proliferation and migration of human vascular smooth muscle cells: similar effects in cells from postmenopausal females and in males
Authors: D Dai-Do
Journal: Cardiovascular Research (1996)

Objectives: Cardiovascular disease is rare in premenopausal women, but increases after the menopause when hormone replacement therapy reduces coronary events.Vascular smooth muscle cell @MC) proliferation and migration occur in atherosclerosis, restenosis and venous graft disease.We studied the effects of 17@estradiol on SMC proliferation and migration.Methods: SMC were cultured from saphenous veins of postmenopausal women and age-matched men.Cell growth was determined by 'H-thymidine incorporation and cell counting.Migration of SMC was assessed in 4-well chambers.SMC were seeded in one comer and PDGF-BB in filter paper glued onto the opposite wall.Results: PDGF-BB (5 rig/ml for 24 h) similarly stimulated 'H-thymidine incorporation in female (5 11 f 57%; n = 8) and male (528 f 62%; R-12) SMC.This was reduced by 17pestradiol (1O-s-1O-6 M, female 313 f 52%; male 337 f 54%; P < 0.05).PDGF-BB increased the number of SMC (P < 0.0001 at 10 days) obtained from females (153 f 3%; n -5) and males (150 f 4%; n = 51, which was inhibited by 17&estradiol (10m6 M, female 134 * 7%; male 128 f 5%; P < 0.05).Similar results were obtained with basic fibroblast growth factor.In contrast to 17P-estradiol, another steroid (dexamethasone) had no effects on 3H-thymidine incorporation in these cells stimulated with PDGF-BB.PDGF-BB (0.01-l ng> stimulated SMC migration (P < 0.05) which was inhibited by 17p-estradiol (10-'"-10-6 M; n -5; P < 0.005).Conclusion: 17@-Estradiol inhibits growth-factor-induced SMC proliferation and migration regardless of gender.These effects of 17@estradiol may contribute to its cardiovascular protective properties in postmenopausal women during replacement therapy.
AIDS and testing for AIDS
Authors: Michael Kanter
Journal: JAMA (1986)

<h3>To the Editor.—</h3> In the recent article, "Status Report on the Acquired Immunodeficiency Syndrome," the Council on Scientific Affairs<sup>1</sup>calculated that testing blood components for human T-cell lymphotropic virus type III (HTLV-III) using Abbott Laboratories' enzyme-linked immunosorbent assay kit would result in 20,000 positive results annually. This calculation assumed there are 20 million blood donors annually and a prevalence rate of HTLV-III antibody in the general population of 0.1%. Unfortunately, the number of donors (D) multiplied by the prevalence of the antibody (P) equals the number of persons with HTLV-III antibody, not the number of positive test results, as these authors concluded. The number of positive results in fact is the sum of the number of true-positives plus the number of false-positives. Standard probability theory<sup>2</sup>shows that true-positive equals D × P × sensitivity and false-positive equals D(1—P)(1—specificity). Thus, the expected number of positive results equals D × P
The effect of splenomegaly on splanchnic hemodynamics in nonalcoholic cirrhosis after distal splenorenal shunt and splenopancreatic disconnection
Authors: K Takagi
Journal: Hepatology (1994)

We investigated the effect of splenomegaly on portal hemodynamics during and after distal splenorenal shunt with splenopancreatic disconnection in 27 patients with nonalcoholic cirrhosis (13 with and 14 without splenic enlargement). Data were obtained by Doppler flowmetry, electromagnetic flowmetry and computed tomographical scanning. The splenomegaly group had a significantly higher preoperative splenic and portal blood flow than the nonsplenomegaly group. In both groups, postoperative portal venous pressure did not fall; portal blood flow significantly decreased while splenic volume was reduced, despite the lack of significant changes in splenic venous blood flow. There was a greater reduction of portal blood flow with previous splenomegaly than with normal-sized spleens, and this was not related to the degree of reduction in liver volume. In the splenomegaly group, the increase of splenic blood flow was only present during the early postoperative period. In conclusion, distal splenorenal shunt with splenopancreatic disconnection influenced portal hemodynamics differently in nonalcoholic cirrhotic patients with and without splenomegaly. (Hepatology 1994;20:342–348.)
VON DER NERVENZELLE UND DER ZELLE IM ALLGEMEINEN. Von Paul Kronthal. Mit 6 chromolithographischen, 3 heliographischen Tafeln und 27 Figuren im Text.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of acute cold agglutinin hemolytic anemia with transfusion of adult i RBCs
Authors: J. E. Woll
Journal: JAMA (1974)

ACUTE cold agglutinin disease with severe hemolysis following primary atypical pneumonia was first described in 1943 by Horstmann and Tatlock.<sup>1</sup>In a 1945 review of 200 cases of primary atypical pneumonia, 11 had hemolytic anemia of varying severity, which resulted in two deaths.<sup>2</sup>Despite subsequent identification of the specificity of the cold autoantibody (anti-I), transfusion of such patients has been limited by the difficulty in obtaining compatible blood. We report a patient with severe hemolysis associated with acute postinfectious cold agglutinin disease who was treated with transfusions of the rare, type i red blood cells (RBCs). <h3>Report of a Case</h3> A 51-year-old nulliparous white woman was admitted in October 1972 with a twoweek history of fever and cough, productive of yellow sputum, for which she took prescribed tetracycline for ten days. The fever remitted, but the cough persisted. Two days before admission, nausea and vomiting developed, and the
Wording Clarification
Authors: Devin Zarkowsky, Caitlin Hicks, J Canner, I Arhuidese, U Qazi, E Schneider, C Abularrage, Mahmoud Malas
Journal: JAMA Surgery (2016)

Gregory B. Auffenberg, MD; Khurshid R. Ghani, MBChB, MS; Zaojun Ye, MS; Apoorv Dhir, BBA; Yuqing Gao, MS; Brian Stork, MD; David C. Miller, MD, MPH