tbuckley/cabot-search huggingface dataset:
Cutis marmorata telangiectatica congenita associated with an elevated maternal serum human chorionic gonadotrophin level and transitory isolated fetal ascites
Authors: C-P. CHEN, H-C. CHEN, F-F. LIU, S-W. JAN, S-R. CHERN, T-Y. WANG, H-Y. HUNG
Journal: British Journal of Dermatology (1997)

A 34–year–old woman with an abnormal maternal serum screening result and a Down syndrome risk of 1:60 calculated from a maternal serum alpha–fetoprotein (AFP) value of 1.4 multiples of the median (MoM) and a human chorionic gonadotrophin (hCG) level of 4.32 MoM at 18 weeks' gestation was found to have isolated fetal ascites at 23 weeks' gestation. Spontaneous resolution occurred 10 weeks after the initial presentation. After birth, the neonate had generalized cutis marmorata telangiectatica congenita (CMTC), large vascular plaques on the scalp with superficial ulceration and crusts, a small atrial septal defect, a patent ductus arteriosus, hepatomegaly, micrognathia, seizures, an abnormal electroencephalogram, congenital retinal detachment, glaucoma and widely spaced toes. Our patient illustrates that CMTC in utero may be associated with a markedly elevated maternal serum hCG level as well as transitory isolated fetal ascites. However, such associations can be coincidental and further collaborative studies and cases will be necessary before it can be determined that a disproportionately elevated hCG level and transitory isolated fetal ascites are predictive of CMTC in utero.
Plantar Pseudochromidrosis
Authors: Fred Levit
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Plantar pseudochromidrosis is a benign, self-limited condition which is probably caused by trauma. It is probably very common but is not mentioned in standard textbooks. It is most likely to be confused with plantar wart or malignant melanoma. Trimming the surface of the lesion will usually make the correct diagnosis possible. Although it is probably fairly common, it is not well known, and is represented in the United States literature by a single report. <h3>Report of a Case:—</h3> A 19-year-old youth, who was being treated for acne, asked about some black spots on his foot. These consisted of a cluster of dark-red to black dots covering an area about 1.5-cm square on the posterolateral surface of one heel (Figure). The keratin in the area involved was no thicker than that of the uninvolved foot, and the lesion was not tender. When the lesion was trimmed the dark
Cutaneous tuberculosis in Blackburn district (U.K.): a 15-year prospective series, 1981-95
Authors: V.M. YATES, L.P. ORMEROD
Journal: British Journal of Dermatology (1997)

Data collected prospectively on all 1065 cases of tuberculosis occurring in the Blackburn district, U.K. (population 265.000), over a 15-year period have been analysed, and from these 47 cases of cutaneous tuberculosis have been identified. The most common form was scrofuloderma, skin involvement with adjacent structural disease, of which there were 2b cases (55. 3%). There was no ethnic bias in this group. The eight white patients with scrofuloderma were of average age 66 years, and are thought to represent reactivation disease.Six palients (12.8%) had lupus vulgaris, four (8.5%) had metastatic tuberculosis and 10 (21.3%) were diagnosed as having one of the tuberculides, of which Bazin's disease (erythema induratum) was the most common. In addition, one patient (2.2%) had orificial tuberculosis. In contrast to scrofuloderma. all other forms of cutaneous tuberculosis occurred almost exclusively in patients from the Indian Subcontinent (ISC).The high incidence of tuberculosis in Blackburn is mainly linked to its significant proportion of residents of ISC ethnic origin. There were no cases of HIV infection coexisting with either cutaneous or other forms of tuberculosis. Recommendations for the treatment of cutaneous tuberculosis are made.
The Radiological Diagnosis of Herniated Lumbar Intervertebral Disk
Authors: Stephen A. Kieffer
Journal: JAMA (1984)

LUMBAR disk herniation was not fully recognized as a disease entity until 1934, when Mixter and Barr<sup>1</sup>published their now classic description. Only two years later, Hampton and Robinson<sup>2</sup>described the myelographic criteria for the diagnosis of this entity. For almost 50 years, myelography with radiopaque contrast media has been the diagnostic method of choice for detection and localization of herniated lumbar intervertebral disk.<sup>3-8</sup>The recent development of nonionic water-soluble iodinated contrast media with relatively low toxicity (eg, metrizamide)<sup>9,10</sup>has added a new dimension to the myelographic evaluation of disk herniation by allowing direct visualization of the compressed nerve root.<sup>6</sup> Although the use of water-soluble contrast agents has now become widely accepted and has likely improved the diagnostic accuracy of the myelographic method,<sup>6</sup>Williams and colleagues" have recently suggested that the diagnosis of herniated lumbar disk can be made in many cases by computed
Measurement error
Authors: J. Masse, J M Bland, J R Doyle, J M Doyle
Journal: BMJ (1997)

<h3>Objectives</h3> Socioeconomic inequalities in oral health are often neglected in oral health promotion. This cross-sectional study assessed the association between dental caries and socioeconomic status (SES) among preschool children in China. <h3>Design</h3> Cross-sectional study. <h3>Setting</h3> Data from the Fourth National Oral Health Survey of China (2015), comprising of 40 360 children aged 3–5 years was used. <h3>Methods</h3> Dental caries indicators including prevalence of dental caries, dental pain experience and number of decayed, missing and filling teeth (dmft). SES indicators included parental education and household income. The associations between SES and dental caries were analysed by using negative binomial regression or Poisson regression models according to data distribution. Relative and absolute inequalities in dental caries were quantified by using the Relative Index of Inequality (RII) and Slope Index of Inequality (SII), respectively. <h3>Results</h3> There were significant associations between SES and prevalence of dental caries and dmft (p&lt;0.001). Children from lower educated (RII 1.36, 95% CI 1.3 to 1.43; SII 0.97, 95% CI 0.81 to 1.13) and lower household income (RII 1.17, 95% CI 1.11 to 1.24; SII 0.55, 95% CI 0.35 to 0.75) families had higher dmft than those from well-educated and most affluent families. Relative and absolute inequalities in dental caries were larger in urban areas by household income, and in rural areas by parental education. <h3>Conclusions</h3> Association between dental caries and SES was demonstrated and socioeconomic inequalities in dental caries existed among Chinese preschool children.
Highlights of This Issue
Journal: Clinical Cancer Research (2018)

Uckermann and colleagues use infrared spectroscopy and present a translational approach for fast, label-free optical analysis of the IDH1 genotype of human glioma. Based on the initial research performed on cell lines and tumor cryosections, fresh glioma biopsies were classified regarding their IDH1 genotype with an accuracy of 86%. Because IDH1 mutations are early events in glioma formation with prognostic impact and most likely dichotomizing therapeutic decision making, analysis of the tumor's spectrome might be exploited to complement histopathology and molecular pathology for an in situ diagnostic screen.Clinical utilization of circulating tumor cells (CTC) as a biomarker has been limited by the low sensitivity of CTC assays. Myung and colleagues demonstrate that CTC capture can be improved through two innovative concepts: biomimetic cell rolling and nanotechnology-enabled multivalent binding capture. The investigators show that the new assay can capture high numbers of CTCs in a diverse cohort of patients. Moreover, CTC change is correlated with treatment response and disease status. These findings hold potential for clinical translation.Both EGFR and VEGF are validated targets for treatment of patients with metastatic colorectal cancer (mCRC); however, combinations of monoclonal antibodies targeting both pathways show disappointing results. Mésange and colleagues show that combinations of bevacizumab and erlotinib, a small molecule EGFR inhibitor, have activity in CRC models independent of RAS status and bevacizumab resistance. The results provide a molecular framework to better understand the increased activity of the bevacizumab-erlotinib combination, compared with bevacizumab alone, in the GERCOR DREAM phase III clinical trial. Differential activity of mAb and TKI targeting the same signaling pathway is likely applicable for other tumor types.Attempts at treating glioblastoma (GBM) patients with checkpoint inhibitors have failed to provide a survival benefit. A potential mechanism explaining the failure of PD-1 blockade is based on work showing that GBM-infiltrating T cells increase immunosuppressive indoleamine 2,3 dioxygenase 1 (IDO1) levels. Ladomersky and colleagues tested IDO1 inhibitor and PD-1 mAb treatment, with or without radiotherapy, and found that the combination of all three agents led to long-term survival in a substantial fraction of mice with intracranial GBM. These data provide rationale for the soon-to-open phase I/IIa clinical trial of simultaneous radiotherapy with PD-1 and IDO1 inhibition in GBM patients.
A Manual of Clinical Laboratory Methods.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vibrio parahaemolyticus in Brazilian Coastal Waters
Authors: Solange M. C. Franca
Journal: JAMA (1980)

<i>Vibrio parahaemolyticus</i>has been increasingly recognized as an important cause of acute diarrheal illness in Asia, Europe, Africa, Australia, and North America. We investigated whether this pathogen was also present in Brazil and found that 10% of the fish samples studied were contaminated with this halophilic vibrio. Positive cultures were obtained in three of 64 fish (5%) and in seven of 36 shellfish (19%). (<i>JAMA</i>244:587-588, 1980)
Diseases of Nutrition and Infant Feeding.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: Clinical Cancer Research (2004)

In the article by R. W. Tsang et al., which appeared in the October 1, 2003 issue of Clinical Cancer Research (pp. 4387–4395), two author names were inadvertently omitted: Wilfred Levin and Lee A. Manchul. The correct author list is: Richard W. Tsang, Stephen Juvet, Melania Pintilie, Richard P. Hill, C. Shun Wong, Michael Milosevic, William Chapman, Wilfred Levin, Lee A. Manchul, and Anthony W. Fyles.
Maternal Hormone Measurements
Authors: Alan S. Clepper
Journal: JAMA (1983)

<h3>To the Editor.—</h3> In a recent reply in the QUESTIONS AND ANSWERS section ofThe Journal(1982;248:1109) relating to the use of maternal hormone measurements in the management of high-risk pregnancies, Duenhoelter correctly emphasizes the high incidence of false-positive results (ie, low values in the absence of fetal jeopardy) from maternal estriol and human placental lactogen assays. However, I believe that the companion assertion of a high incidence of false-negative estriol results would probably be challenged by most contributors to this area of inquiry. In fact, properly performed (radioimmunoassay) serum or urine estriol assays have low incidences of false-negative results (normal values in the presence of fetal jeopardy), probably lower than any of the other chemical or biophysical measurements. Even so, one cannot predict how long the safety inherent in a normal estriol value will last, in contrast, for instance, to the five- to seven-day assurance offered by a normal
Transurethral Resection of the Prostate with and without Continuous Irrigation
Authors: Richard G Notley
Journal: Journal of the Royal Society of Medicine (1982)

Four hundred patients undergoing transurethral resection of the prostate have been studied. An intermittent irrigation resectoscope was used in 200, and a continuous irrigation resectoscope in the remainder. The merits and demerits of continuous irrigation resection are discussed in the light of the results of these operations. The conclusion reached is that the continuous irrigation resectoscope has considerable advantages over the intermittent flow instrument. These advantages are most evident in the difficult operation, or in operations on the larger prostate, as well as in the tuition and demonstration of endoscopic surgery.
Analysis of the precore DNA sequence and detection of precore antigen in liver specimens from patients with anti-hepatitis b e—positive chronic hepatitis
Authors: Hans Peter Dienes, Guido Gerken, Bernd Goergen, Klaus Heermann, Wolfram Gerlich, Meyer K. H. zum Büschenfelde
Journal: Hepatology (1995)

A number of naturally occurring hepatitis B virus (HBV) mutants unable to synthesize the hepatitis B e antigen (HBeAg) have been identified in patients characterized by HBV DNA and anti-HBe in their serum. Because the analysis of the HBV-associated DNA and antigens in the liver tissue is still not complete, we investigated the precore sequence of HBV DNA and its encoded proteins in the liver tissue of 32 patients positive for HBV DNA and anti-HBe in their serum. Three different groups of patients were identified. Group I (n = 14) was characterized by viral DNA sequences with a G-A transition in the distal precore gene region, thus creating a termination codon (TAG). Liver tissue from this group was negative for HBeAg but positive for hepatitis B core antigen (HBcAg) and a peptide containing the last 10 aminoacids of the precore and the first four aminoacids of the c region. Group II (n = 6) showed variable mutations in base sequences further upstream and negative for HBeAg and the precore peptide. Group III (n = 12) contained wild-type HBV DNA sequences in the tissue and positivity for precore- and core-encoded proteins. We conclude from our study that the group of patients with HBV DNA and anti-HBe in the serum is rather heterogeneous, including HBV DNA mutations in the precore region as well as infection with the wildtype virus being negative for HBeAg in the serum. The precore peptide is produced and expressed in the tissue even when the formation of a stop codon at base 1896 prevents the complete translation of the entire HBe protein. (Hepatology 1995;21:1-7).
Insidious and Prolonged Antagonism of Guanethidine by Amitriptyline
Authors: Jerry F. Meyer
Journal: JAMA (1970)

A hypersensitive, 47-year-old man was adequately treated with guanethidine sulfate, 75 mg/day. Because of depression he was treated with amitriptyline hydrochloride, 25 mg, three times daily, and 300 mg of guanethidine sulfate was required for adequate control. Administration of amitriptyline was discontinued and the patient experienced pronounced orthostatic hypotension with 87.5 mg of guanethidine sulfate daily. After five days of amitriptyline hydrochloride therapy, 150 mg/day, the effects of guanethidine were again eliminated. The hypotensive effect of guanethidine did not return until 18 days after amitriptyline therapy was discontinued.
The Human Skeleton: An Interpretation.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RESEARCH DEFENCE SOCIETY
Journal: BMJ (1919)

THE annual meeting of the Research Defence Society was held on Friday, June 3, at the Royal College of Physicians, and was very largely attended. The chair was taken by the Earl of Cromer, president of the society. The other speakers were the Hon. Sydney Holland, chairman of committee, Sir Richard Douglas Powell, Sir David Bruce, Mr. Anthony Hope Hawkins, and Mrs. Scharlieb. The work and the literature of the society are by this time well known to the public, and the annual report shows a great increase in the membership and in the extent of the work.
The protective effect of nedocromil sodium and other drugs on airway narrowing provoked by hyperosmolar stimuli: A role for the airway epithelium?☆☆☆★★★
Authors: Sandra D. Anderson, Leanne T. Rodwell, Evangelia Daviskas, Joanne F. Spring, Jacqueline du Toit
Journal: Journal of Allergy and Clinical Immunology (1996)
POS0126 UTILITY OF THE SUBCHONDRAL BONE ATTENUATION COEFFICIENT OF THE SACROILIAC MARGINS TO DIFFERENTIATE SPONDYLOARTHRITIS AND OSTEITIS CONDENSANS ILII
Authors: A. Terrier, O. Fakih, M. Chouk, C. Prati, D. Wendling, S. Aubry, F. Verhoeven
Journal: Annals of the Rheumatic Diseases (2022)

<h3>Background</h3> Differentiating ankylosing spondylitis (AS) from osteitis condensans ilii (OCI) remains challenging for clinicians. <h3>Objectives</h3> The aim of this study was to determine whether Subchondral Bone Attenuation Coefficient of the SacroIliac margins (SBAC-SI) is different in AS, OCI and diffuse idiopathic skeletal hyperostosis (DISH). <h3>Methods</h3> A monocentric retrospective observational study was performed at a French University Hospital. Patients included were followed for AS, DISH or OCI and underwent CT scan including sacroiliac joint. Patients with tumor lesion of bone or a history of pelvic radiotherapy were excluded. AS and OCI patients were matched with a control of the same age and sex. All scans were acquired on the same CT-scan unit (Somatom 64 definition AS+, Siemens Healthineers, Erlangen, Germany), with a slice thickness of 0.625 mm. In the coronal oblique plane of the SIJ, three slices (anterior, middle and posterior) and four quadrants per joint were defined. Twenty-four identical circular regions of interest (ROIs) (30 mm2), 8 per slice, were manually placed separately subcortical to the SIJ, four on the sacral side and four on the iliac side. The distance between the circle of the ROI and the cortical bone was 2 to 3 mm. An overall score was obtained from the sum of all ROIs. For every ROI, an Attenuation Coefficient was measured and expressed in Hounsfield Unit. The total SBAC-SI score was the sum of the 24 ROI. The sacral and iliac SBAC-SI scores were the sum of the sacral or the iliac ROI. <h3>Results</h3> Thirty AS and AS controls, 31 DISH, 29 OCI and OCI controls were included. SBAC-SI score was 9727 (±2430) in the OCI group (p&lt;0.001), 3563 (±1860) in the AS group, 3899 (±1937) in the DISH group, 4224 (±1693) in the AS control group and 5445 (±1205) in the OCI control group. A threshold of 7500 HU had the best discriminative value between OCI and AS (youden index: 0.89). In AS, disease duration is negatively associated with SBAC-SI (r: -0.623; p&lt; 0.01) and HLA B27 is associated with lower SBAC-SI (6523 [5198; 7137]VS 2809 [1568; 3371]; p &lt;0.001). <h3>Conclusion</h3> SBAC-SI is significatively different between AS and OCI and could help to distinguish these two diseases. <h3>Disclosure of Interests</h3> None declared
Use of Carotid Endarterectomy in Five California Veterans Administration Medical Centers
Authors: Nancy J. Merrick
Journal: JAMA (1986)

Although carotid endarterectomy is a controversial and frequently performed surgical procedure, little is known about the clinical appropriateness of its use in actual practice. Are the majority of procedures performed for highly accepted clinical reasons? We studied the clinical appropriateness of 107 procedures performed on 95 patients in 1981 in five Veterans Administration teaching medical centers. Standards for judging appropriate use were based on the recommendations of a multidisciplinary panel of nine physicians. Fifty-five percent of the procedures studied were judged clearly appropriate, 32% equivocal, and 13% clearly inappropriate. The rate of serious operative complications was 5.6% These results suggest that carotid endarterectomy is overutilized within at least some segments of the Veterans Administration population. (<i>JAMA</i>1986;256:2531-2535)
Intelligence and reasoning are not one and the same
Authors: I.A. Noveck, J. Prado
Journal: Behavioral and Brain Sciences (2007)

Abstract Lest the conjunction “intelligence and reasoning” seduce readers into supposing that the two are of a piece, we point out that analyses made at the superset level concerning intelligence do not readily align with or outperform the scientific advances made via investigations of reasoning , which at best can be viewed as a subset of intelligent behaviour.