tbuckley/cabot-search huggingface dataset:
Highlights of This Issue
Journal: Clinical Cancer Research (2014)

Treatment options for triple negative breast cancer (TNBC) patients are limited in scope and effectiveness, particularly in the metastatic setting. Proia and colleagues show that the TNBC phenotype is highly sensitive to the pleiotropic effects of HSP90 inhibition using the investigational drug ganetespib. Ganetespib simultaneously deactivated multiple oncogenic pathways in TNBC cells, suppressed lung metastasis in mouse models, and potentiated the antitumor activity of standard-of-care TNBC chemotherapeutics in vitro and in tumor xenografts. Shrinkage of metastatic lung and lymphatic lesions were observed in patients undergoing ganetespib monotherapy. These findings support the continued exploration of ganetespib for the clinical management of TNBC.Little is known about T-cell responses against advanced epithelial cancers. By establishing new cancer cell lines and expanding tumor-infiltrating lymphocytes from the same patients, Turcotte and colleagues provide evidence at the clonal and molecular level that naturally occurring CD8+ T cells can exhibit tumor specificity against gastrointestinal cancer metastases. This observation represents a rational basis for the development of T cell-based treatments for patients with these malignancies, which will have to take into account the low frequency of tumor-reactive T cells, the absence of shared antigen recognition across allogeneic tumors, and the heterogeneity in antigen expression by tumors.Ductal carcinoma in-situ (DCIS) is the main precursor of invasive breast cancer and accounts for 25–30% of all breast cancers. Only half will progress to invasive disease during a woman's lifetime, but currently there are no markers for predicting which patients might progress. Allen et al demonstrate that tumor-suppressive myoepithelial cells are altered in a subset of DCIS through up-regulation of integrin αϖβ6 and is significantly associated with recurrence and progression. In-vivo and In-vitro expression of αϖβ6 in myoepithelial cells enhances tumor growth and invasion. This suggests that myoepithelial αϖβ6 may be of prognostic importance and help stratify patient care.Antiangiogenic treatments that target pathways other than VEGF have the potential to treat patients who have progressed despite anti-VEGF therapy and to improve outcomes when used in combination with VEGF-directed therapies. Bendell and colleagues describe the phase I clinical evaluation of dalantercept, a receptor fusion protein that inhibits BMP9/BMP10/ALK1 signaling, in adults with advanced solid tumors. Dalantercept exhibited a safety profile distinct from that of VEGF inhibitors and displayed multiple signs of antitumor activity, including a partial response, long-term stable disease, and correlative pharmacodynamic activity assessed by functional imaging. The BMP9/BMP10/ALK1 pathway is a promising target for antiangiogenic cancer therapy.
Trends in Sexual Risk Behaviors Among High School Students--United States, 1991-2001
Journal: JAMA (2002)

Unprotected sexual intercourse places young persons at risk for human immunodeficiency virus (HIV) infection, other sexually transmitted diseases (STDs), and unintended pregnancy. Responsible sexual behavior among adolescents is one of the 10 leading health indicators of the national health objectives for 2010 (objective 25.11). To examine changes in sexual risk behavior that occurred among high school students in the United States during 1991-2001, CDC analyzed data from six national Youth Risk Behavior surveys (YRBS). This report summarizes the results of the analysis, which indicate that, during 1991-2001, the percentage of U.S. high school students who ever had sexual intercourse and the percentage who had multiple sex partners decreased. Among students who are currently sexually active, the prevalence of condom use increased, although it has leveled off since 1999. However, the percentage of these students who used alcohol or drugs before last sexual intercourse increased. Despite decreases in some sexual risk behaviors, efforts to prevent sexual risk behaviors will need to be intensified to meet the national health objective for responsible sexual behavior.
An Atlas of Human Anatomy. For Students and Physicians.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Kaposi's varicelliform eruption
Authors: K. M. Halprin
Journal: JAMA (1967)

Numerous vesicles and pustules superimposed on underlying dry eczematous dermatitis suddenly developed in a child with infantile eczema (Figure). A diagnosis of "bacterial infection" led to antibiotic therapy but the lesions continued to spread and were unresponsive to a second antibiotic. These lesions were unresponsive to antibiotic therapy because the clinical sequence of events is typical of the common viral invasion of eczematous skin originally described by Kaposi. The umbilicated vesicles resemble the lesions of varicella (chicken pox) and therefore led to the name in the title but the causative organism is herpes simplex or vaccinia virus. In infants primary infection by these viruses may be accompanied by severe manifestations of toxicity, fever, and lymphadenopathy. Systemic infection with hepatitis, meningitis, and encephalitis may lead to death and prompt supportive measures are needed. Older children and adults on the other hand are usually affected by recurrent herpes infection. They already have
Practical Obstetrics for Students and Practitioners
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cryocauterization of the Vas Deferens
Authors: P L R Dias
Journal: Journal of the Royal Society of Medicine (1982)

An isolated segment of the vas deferens 2–3 cm long was cauterized using cryotherapy in 10 acceptors of voluntary sterilization to determine whether this method could be successfully employed as an alternative to vasoligation and resection. Three months postoperatively 8 patients were azoospermic but 2 patients were oligospermic. Due to the high failure rate this method cannot be recommended as a routine procedure.
Neoplasms in Young Dogs After Perinatal Irradiation&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1986)

For a study of the life-time effects of irradiation during development, 1,680 beagles were given single, whole-body exposures to 60Co γ-radiation at one of three prenatal (preimplantation, embryonic, and fetal) or at one of three postnatal (neonatal, juvenile, and young adult) ages. Mean doses were 0, 0.16, or 0.83 Gy. For comparison with data on childhood cancer after prenatal irradiation, examination was made of tumors occurring in young dogs in this life-span experiment. Up to 4 years of age, 18 dogs had neoplasms diagnosed, 2 of these being in controls. Four dogs that were irradiated in the perinatal (late fetal or neonatal) period died of cancers prior to 2 years of age. This risk was of significant increase compared to the risks for other experimental groups and for the canine population in general. Overall, 71% (5 of 7) of all cancers and 56% (10 of 18) of all benign and malignant neoplasms seen in the first 4 years of life occurred in 29% (480 of 1,680) of the dogs irradiated in the perinatal period. These data suggest an increased risk for neoplasia after perinatal irradiation in dogs.
Lithium Carbonate and Kidney Function
Authors: T. Alan Ramsey
Journal: JAMA (1972)

Three patients with manic-depressive illness who were successfully treated with lithium carbonate developed polyuria and polydipsia at varying periods after starting treatment. Water deprivation studies revealed a defect in renal concentrating ability which was not corrected by the administration of vasopressin injection. None of the patients had elevated urine volumes prior to lithium carbonate therapy, and there was no evidence of other conditions which might have affected renal concentrating ability.
Tularemia—United States, 1990-2000
Journal: JAMA (2002)

Tularemia is a zoonotic disease caused by the gram-negative coccobacillus Francisella tularensis. Known also as "rabbit fever" and "deer fly fever," tularemia was first described in the United States in 1911 and has been reported from all states except Hawaii. Tularemia was removed from the list of nationally notifiable diseases in 1994, but increased concern about potential use of F. tularensis as a biological weapon led to its reinstatement in 2000. This report summarizes tularemia cases reported to CDC during 1990-2000, which indicate a low level of natural transmission. Understanding the epidemiology of tularemia in the United States enables clinicians and public health practitioners to recognize unusual patterns of disease occurrence that might signal an outbreak or a bioterrorism event.
Еволюція зондових методів досліджень в гастроентерології: огляд і власні дослідження
Authors: Yu.M. Stepanov, L.M. Mosiychuk, I.V. Kushnirenko
Journal: GASTROENTEROLOGY (2014)

Стаття присвячена огляду сучасних методів, що надають можливість визначити функціональний стан шлунка, стравоходу. У зв’язку з удосконаленням сучасних методів дослідження особливого значення набувають методи, здатні здійснювати графічну реєстрацію фізіологічних процесів. Прогресування технічних можливостей сприяло розвитку методик, суть яких полягає у тривалій реєстрації показників датчиків, розташованих на внутрішньопорожнинних катетерах. Так, метод внутрішньопорожнинної рН-метрії полегшує діагностику внутрішньошлункового рівня рН та, що є дуже важливим, внутрішньостравохідного. До сьогодні метод внутрішньостравохідного рН-моніторингу вважався золотим стандартом для діагностики гастроезофагеальної рефлюксної хвороби (ГЕРХ). Представлені результати власних досліджень внутрішньостравохідного рН-моніторингу у хворих на ГЕРХ. Але багатогодинний рН-моніторинг у стравоході виявляє лише кислі рефлюкси, а лужні та слаболужні рефлюкси залишається за межами цього методу дослідження, тому для остаточного виявлення причин виникнення симптомів ГЕРХ пропонується методика імпеданс-рН-моніторингу. Метод імпеданс-рН-моніторингу запропонований у 1991 році J. Silny як метод, заснований на оцінці руху рідини, газу у просвіті стравоходу на підставі багатократних вимірювань імпедансу з одночасною реєстрацією рівня рН. Технічні можливості імпеданс-рН-моніторингу дозволили розширити уявлення про фізіологічні процеси у просвіті стравоходу та визначити роль змішаних, лужних рефлюксів у розвитку симптомів ГЕРХ. У статті висвітлені результати низки досліджень, проведених у пацієнтів різних груп із патологією верхнього відділу травного тракту, що свідчать про перевагу імпеданс-рН-моніторингу та його високий рівень чутливості та специфічності щодо реєстрації рефлюксів. Широке впровадження новітніх методик та технологій у клінічну практику дозволить збільшити ефективність та своєчасність надання медичної допомоги, уникаючи витрат часу на добір терапії, оцінку її ефективності.
A multicentre (double-blind) comparative study to assess the safety and efficacy of fluconazole and griseofulvin in the treatment of tinea corporis and tinea cruris
Authors: J. FAERGEMANN, N.J. MÖRK, A. HAGLUND, T. ÖDEGÀRD
Journal: British Journal of Dermatology (1997)

In a double‐blind, parallel group study we compared fluconazole 150mg once weekly with griseofulvin 500 mg once daily for 4–6 weeks in the treatment of tinea corporis or tinea cruris. Eighty‐four of 114 patients (74%) (39% after 3 weeks) were clinically cured in the fluconazole group compared with 72 of 116 (62%) (39% after 3 weeks) in tbe griseofulvin group (P = 0·06). In tbe fluconazole group 78% were mycological cured compared with 80% in the griseofulvin group. In the fluconazole group nine patients (7·5%) had treatment related adverse events and in tbe griseofulvin group 15 patients (12·5%) had adverse events. Fluconazole 150 mg once weekly for 6 weeks is botb clinically and mycologically effective in the treatment of tinea corporis and tinea cruris and few side‐effects were reported.
OCCLUSION OF MESENTERIC VESSELS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1989 Lasker Awards Salute Physician-Author, Four Cell Biologists, French Endocrinologist
Authors: Marsha F. Goldsmith
Journal: JAMA (1989)

SIGNAL TRANSDUCTION — the process that enables each cell to receive and respond to signals from extracellular messengers like hormones, growth factors, and neurotransmitter molecules, allowing cells within an organism to communicate with each other—was discovered and elucidated in work done by the four recipients of this year's Albert Lasker Basic Medical Research Awards. The winner of the Clinical Research Award has made discoveries of primary importance in endocrinology, and the Public Service Award goes to an acclaimed physician—biomedical writer. Articles by most of this year's recipients appear in this issue of<i>JAMA</i>on pages 1808-1840. The winners are: <b>Edwin G. Krebs</b>, MD, senior investigator at the Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, "for his seminal finding that phosphorylation activates major enzymes in cells, and for perceiving the profound importance of protein kinase enzymes." Discoveries made by Krebs (who is unrelated to Nobel laureate Hans
Induction of Unscheduled DNA Synthesis in Rat Stomach Mucosa by Glandular Stomach Carcinogens&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1984)

Journal Article Induction of Unscheduled DNA Synthesis in Rat Stomach Mucosa by Glandular Stomach Carcinogens Get access Chie Furihata, Chie Furihata 4Department of Molecular Oncology, Institute of Medical Science, University of Tokyo, Shirokanedai 4-6-1, Minato-ku, Tokyo 108, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Yuko Yamawaki, Yuko Yamawaki 4Department of Molecular Oncology, Institute of Medical Science, University of Tokyo, Shirokanedai 4-6-1, Minato-ku, Tokyo 108, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Shen-Su Jin, Shen-Su Jin 4Department of Molecular Oncology, Institute of Medical Science, University of Tokyo, Shirokanedai 4-6-1, Minato-ku, Tokyo 108, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Hiroki Moriya, Hiroki Moriya 4Department of Molecular Oncology, Institute of Medical Science, University of Tokyo, Shirokanedai 4-6-1, Minato-ku, Tokyo 108, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Kyoko Kodama, Kyoko Kodama 4Department of Molecular Oncology, Institute of Medical Science, University of Tokyo, Shirokanedai 4-6-1, Minato-ku, Tokyo 108, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Taijiro Matsushima, Taijiro Matsushima 4Department of Molecular Oncology, Institute of Medical Science, University of Tokyo, Shirokanedai 4-6-1, Minato-ku, Tokyo 108, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Takatoshi Ishikawa, Takatoshi Ishikawa 6Department of Experimental Pathology, Cancer Institute, Kami-Ikebukuro 1-37-1, Toshima-ku, Tokyo 170, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Shozo Takayama, Shozo Takayama 6Department of Experimental Pathology, Cancer Institute, Kami-Ikebukuro 1-37-1, Toshima-ku, Tokyo 170, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Masahiro Nakadate Masahiro Nakadate 7Department of Synthetic Chemistry, National Institute of Hygienic Sciences, Kamiyoga 1-18-1, Setagaya-ku, Tokyo 158, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 72, Issue 6, June 1984, Pages 1327–1334, https://doi.org/10.1093/jnci/72.6.1327 Published: 01 June 1984 Article history Received: 19 July 1982 Revision received: 07 January 1984 Accepted: 20 January 1984 Published: 01 June 1984
Encyclopedia of X-Rays and Gamma Rays.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Arterial Reconstruction to the Anterior Tibial Artery at the Ankle
Authors: John L. Ochsner
Journal: JAMA (1967)

Reconstructive arterial surgical procedures have progressively improved with time. Refinement in instruments, increased surgical experience, and better understanding of the pathophysiology of arterial disease have enabled the surgeon to reestablish circulation to distal sites heretofore believed uncorrectable. Reported here is the technique used to restore blood flow to the distal anterior tibial artery and foot. Progressive refinements in vascular surgical techniques will continue to reduce the limitation in salvage of limbs with arterial disease.
Treatment of Phenobarbital Overdose With Activated Charcoal
Authors: Mark J. Goldberg
Journal: JAMA (1982)

Patients with phenobarbital overdose who are treated only with supportive care may remain comatose for several days because of the long elimination half-life of phenobarbital. We treated two patients with phenobarbital overdoses with the nasogastric administration of multiple doses of activated charcoal. This safe therapy markedly shortened both the elimination half-life of phenobarbital and the duration of coma in these patients. If all such patients respond similarly, we believe that the nasogastric administration of multiple doses of activated charcoal is the method of choice to accelerate the elimination of phenobarbital from the body. (<i>JAMA</i>1982;247:2400-2401)
Cor Pulmonale From Airway Obstruction in Children
Authors: Moshe Steier
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Cor pulmonale due to upper airway obstruction is a rare disease in young children<sup>1</sup>; however, its recognition has great importance because correct management can be lifesaving. Therapeutic intervention can be achieved in many cases by removing the tonsils and adenoids.<sup>1-3</sup>Any young child with recurrent respiratory infections, stridorous breathing, and lethargy should be investigated for<i>upper</i>airway obstruction. The syndrome manifests itself in many ways of which the following case is an example. <h3>Report of a Case.—</h3> A 3-year-old black boy had undergone multiple admissions to different hospitals in New York City for "bronchitis," "pneumonia," "febrile convulsion," "lethargy," and "drug intoxication and foreign body in the right main stem bronchus." His last admission, to the Mount Sinai Hospital, was marked by inspiratory stridor, particularly in the supine position. His tonsils were markedly enlarged. Auscultation of the heart revealed no abnormality except for an accentuated pulmonic