tbuckley/cabot-search huggingface dataset:
A TRUE PATRIOT.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
pH-Sensitive Nano-Complexes Overcome Drug Resistance and Inhibit Metastasis of Breast Cancer by Silencing Akt Expression: Erratum
Authors: Jieying Yin, Tianqun Lang, Dongmei Cun, Zhong Zheng, Yan Huang, Qi Yin, Haijun Yu, Yaping Li
Journal: Theranostics (2020)

[This corrects the article DOI: 10.7150/thno.21516.].
THE PROPOSED VIRGINIA ANTI-KISSING LAW.REVIVAL OF THE HEART BY MASSAGE.LITERATURE REFERENCES.
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ultrasonic diagnosis of placental abnormalities in situ
Authors: C. B. Mulhern
Journal: JAMA (1980)

EXAMINATION of the placenta is routinely performed by the obstetrician at the time of delivery. If any gross abnormality is observed or if the condition of the newborn warrants, the placenta is submitted for pathological evaluation. In essence, this is a retrospective analysis of the placenta. Ultrasound, however, provides a safe noninvasive method for examination of the placenta and its associated abnormalities in situ.<sup>1</sup> This article presents representative cases demonstrating the capabilities of ultrasound in evaluating the macroscopic, antenatal features of placental disorders. The cases reported also illustrate the important role of the ultrasonographer in the antenatal diagnosis of placental abnormalities. This permits prompt institution of therapy or avoidance of other unnecessary diagnostic procedures. As the organ of fetomaternal transfer, the placenta often reflects disorders of the fetus and mother as well as abnormalities of placental development (Table). <h3>Materials and Methods</h3> Commercially available, gray-scale ultrasound units provide excellent anatomic
Late mortality after vagotomy and drainage for duodenal ulcer
Authors: Timothy Eisen, A Leathem
Journal: BMJ (1984)

The prognosis of the disease appears to be more accurately indicated by the intensity with which Helix pomatia lectin binds to primary breast cancer cells than by lymph node involvement.This binding reflects expression of N-acetyl-galactosaminyl glyco- conjugates in the cancer cells.There may be many different glycoconjugates but it would be interesting to know whether CA 50 contains N-acetyl-galactosamine.Professor Holmgren's group suggests that formation of new abnormal carbohydrate structures may be caused by activation of normally unexpressed glycosyltransferases.The observed changes, however, could be due to increased levels of normal glycosyltransferases.We raised an antibody to sialytransferase isolated from human milk, and found a tendency for primary breast cancer with a poor prognosis to show greater binding of this antibody than cancer with a good prognosis.This finding is also of interest because increased sialic acid concentrations have been implicated in increased metastatic potential.
Incorporation of bevacizumab in the treatment of recurrent and metastatic cervical cancer: A phase III randomized trial of the Gynecologic Oncology Group.
Authors: Krishnansu Sujata Tewari, Michael Sill, Harry J. Long, Lois M. Ramondetta, Lisa Michelle Landrum, Ana Oaknin, Thomas J Reid, Mario M. Leitao, Helen E Michael, Bradley J. Monk
Journal: Journal of Clinical Oncology (2013)

3 Background: Vascular endothelial growth factor (VEGF) promotes angiogenesis, a mediator of disease progression in cervical cancer. Bevacizumab (B), a humanized anti-VEGF monoclonal antibody, has shown single-agent activity in pretreated recurrent disease. We aimed to evaluate B in chemotherapy (CTX)-naive recurrent/persistent/metastatic cervical cancer. Methods: Using a 2x2 factorial design, patients were randomly assigned to CTX with or without B 15 mg/kg. The CTX regimens included cisplatin 50 mg/m 2 plus paclitaxel 135-175 mg/m 2 and topotecan 0.75 mg/m 2 d1-3 plus paclitaxel 175 mg/m 2 d1. Cycles were repeated every 21 days until disease progression, unacceptable toxicity, or complete response. Overall survival (OS) was the primary endpoint with a reduction in the hazard of death by 30% using anti-VEGF therapy considered important (90% power, 1-sided alpha=2.5%). Final analysis was planned when 346 deaths were observed. Results: 452 patients were accrued from 4/6/09 to 1/3/12. The scheduled interim analysis occurred after 174 patients had died and showed that the topotecan-paclitaxel backbone was not superior to the cisplatin-paclitaxel backbone. A second interim analysis was conducted after 271 deaths. A total of 225 patients received CTX alone and 227 patients received CTX plus B. The randomized treatment groups were similar with regard to age, histology, performance status, previous platinum as a radiosensitizer, and recurrence, persistence, or advanced disease. The B-to-no-B hazard ratio (HR) of death was 0.71 (97.6% CI 0.54-0.95; 1-sided p=0.0035). Median survival was 17 m (CTX plus B) and 13.3 m (CTX alone). The RR were 48% (CTX plus B) and 36% (CTX alone) (p=0.0078). Treatment with B was associated with more grade 3-4 bleeding (5 vs 1%) thrombosis/embolism (9 vs 2%), and GI fistula (3 vs 0%). Conclusions: For the first time a targeted agent significantly improved OS in gynecologic cancer. The second interim analysis crossed the boundary for efficacy, warranting early release of this information. The nearly 4-month increase in median OS with the addition of B to CTX in women with recurrent cervical cancer is considered to be clinically significant. Clinical trial information: NCT00803062.
Unit of Measure Error
Authors: Ankur Pandya
Journal: JAMA (2018)

is different from the cost-effectiveness threshold used to decide whether to disinvest from an existing strategy. 6 Every dollar spent on health care has an opportunity cost.This money could have been used to fund underused cost-effective health services, invested in nonhealth sectors such as education or housing, or given back to the public in the form of lower taxes (for publicly funded health care) or higher wages (for employerbased health coverage).As Sacristán implies, the ultimate goal of disinvesting from cost-ineffective (low-value) care is not simply to save money but to reallocate limited resources to maximize population health and well-being.
Public pressure ends 'bundled' drug program, but how much cost will drop remains unclear
Authors: P. Cotton
Journal: JAMA (1991)

ANTITRUST SUITS and acts of Congress have pressured the Sandoz Pharmaceuticals Corp of East Hanover, NJ, into "unbundling" its powerful schizophrenia drug clozapine (Clozaril). The change "should make this breakthrough therapy far more widely available," says David Winter, MD, vice president for scientific and external affairs at Sandoz. Whether clozapine will get to the majority of patients who could benefit but now cannot afford it is still unclear. Despite its ability to turn some institutionalized patients into productive citizens, only about 7000 people in the United States are taking it. The "no blood, no drug" rule remains, requiring weekly blood tests for agranulocytosis, a potentially fatal side effect seen in up to 2% of patients. But these tests and distribution of the drug will no longer be done solely by Caremark Homecare Inc of Lincolnshire, Ill. Many state Medicaid programs do not cover clozapine because the bundled, Caremark package costs
Energétique clinique: physiopathologie-thérapeutique. Le sympathique — le vagues les réflexes de la vie organo-végétative.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Initiative aims to bring depression out of shadows, spurs help-seeking
Authors: C. A. Raymond
Journal: JAMA (1988)

A NEW PUBLIC HEALTH campaign now getting under way is intended to bring a common disorder out of the closet in a fashion similar to the way that public health officials sought to make an invisible disorder—hypertension—visible in the 1970s. In this case, however, educators and physicians alike will have to overcome the cultural stigma attached to mental illness. The campaign, known as Depression/ Awareness, Recognition, and Treatment (D/ART), will seek to inform the public about the symptoms and nature of clinical depression, the potential for effective treatment, and the importance of seeking help. <h3>Five Centers</h3> In addition to the public information effort, the National Institute of Mental Health (NIMH), Rockville, Md, has funded five centers around the country to develop short training courses for primary care physicians, mental health professionals, and social workers in their regions. Those centers are located at schools of medicine at the University of Arizona,
Hypertension After Closure of Postnephrectomy Arteriovenous Fistula
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the NIH. Membrane changes in epithelial neoplasms
Authors: C. J. Storad
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke
Journal: New England Journal of Medicine (2021)

To the Editor: Throughout 2020, the global movement for racial equality has led many to reflect on their own biases.While combating racism is vital in every setting, we must also preserve nomenclature in science so that it remains a tool to be wielded in the discovery of truth.Phrases such as "racial bias" and "structural racism" are commonplace in the social sciences literature, but they should be used with caution in scientific study.If the findings of the study by Sjoding et al. 1 are correct, they establish a diagnostic inaccuracy, owing to darker skin color, not a racial bias.The term "racial bias" always refers to decisions that are influenced by a person's race.Medical devices such as pulse oximeters are blind to color and cannot exhibit such a bias.It is worrisome that the study findings have been disseminated across social media as proof of "structural racism in health care." 2 Imprudent use of such terms will inevitably further erode the trust of some Black patients and will contribute to, rather than help to remedy, concerns regarding racism in Western medicine.
THE DANGERS OF PATHOLOGIC WORK.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renal clearance studies
Authors: G. Dunea
Journal: JAMA (1968)

Clearance studies are widely used to assess glomerular filtration rate and renal blood flow and to study the excretion of various substances by the kidney. The renal clearance of a substance represents the virtual or theoretical volume of plasma which is completely cleared of this substance in a given unit of time. It is usually expressed in milliliters per minute and calculated from the formula UV÷P, where U and P represent the urine and plasma concentration and V is the volume of the urine.<sup>1-3</sup>Clearances have played an important role in the study of renal physiology and have provided much circumstantial evidence regarding the relative importance of glomerular and tubular excretory mechanisms. <h3>Urea Clearance</h3> Since retention of urea in the blood is accompanied by decreased urinary excretion, students of renal disease in the early 1900's had attempted to evaluate renal function by relating the concentration of urea in urine
REGISTRATION OF VITAL STATISTICS.
Journal: JAMA (1906)

The significance, then, of slight trauma to joints is its bearing on prognosis.The possibility of such joint changes following trauma must always be borne in mind and a guarded prognosis must be made in many joint injuries, especially those occurring in individuals past 40 years of age and of arteriosclerotic or gouty habit.From a medicolegal standpoint these chronic joint changes are of much interest.Not infrequently claims
Iatrogenic Health
Authors: G. H. Day
Journal: BMJ (1964)

My text is taken, not from the Bible, but from a book which ranks second or third in the hierarchy of bedside and desert- island books.The passage is as follows: ".*.. 'Wot's the matter?' says the doctor.'Wery ill,' says the patient.'Wot have you been a eatin' on?' says the doctor.'Roast weal,' says the patient.' Wot's the last thing you dewoured?' says the doctor.'Crumpets,' says the patient.'That's it!' says the doctor.' I'll send you a box of pills directly, and don't you never take no more of 'em,' he says.'No more o' wot?' says the patient-' Pills?' ' No; crumpets,' says the doctor.'Wy?' says the patient, starting up in bed; 'I've eat four crumpets, ev'ry night for fifteen year, on principle.'' Well, then, you'd better leave 'em off, on principle,' says the doctor.'Crumpets is wholesome, sir,' says the patient.' Crumpets is not wholesome, sir,' says the doctor, wery fierce.' But they're so cheap,' says the patient, comin' down a little, ' and so wery filli' at the price.' ' They'd be dear to you, at any price; dear if you wos paid to eat 'em,' says the doctor.'Four crumpets a night,' he says, 'vill do your business in six months!'The patient looks him full in the face, and turns it over in his mind for a long time, and at last he says, 'Are you sure o' that 'ere sir?' ' I'll stake my professional reputation on it,' says the doctor.'How many crumpets, at a sittin', do you think 'ud kill me off at once?' says the patient.'I don't know,' says the doctor.' Do you think half a crown's wurth 'ud do it?'says the patient.'I think it might,' says the doctor.'Three shillins' wurth 'ud be sure to do it, I s'pose?' says the patient; 'Certainly,' says the doctor.'Wery good,' says the patient; ' good night.'Next mornin' he gets up, has a fire lit, orders in three shillin's' wurth o' crumpets, toasts 'em all, eats 'em all, and blows his brains out."'What did he do that for?' inquired Mr. Pickwick abruptly; for he was considerably startled by this tragical termination of the narrative."'Wot did he do it for, sir?' reiterated Sam.'Wy, in support of his great principle that crumpets wos wholesome,
RENAL TUMORS
Authors: O. A. Nelson
Journal: JAMA (1952)

In dealing with renal tumors the urologic surgeon and the anesthetist often encounter major difficulties. A common understanding of individual problems brought about by joint discussions will result in better teamwork. Their cooperative efforts will be reflected in the statistical analyses of morbidity and mortality. In this discussion a simple classification of renal tumors will be followed. The principal types of renal tumors are hypernephroma, carcinoma of the renal pelvis (papillary, noninfiltrating, or infiltrating) sarcoma, and Wilms' tumor. In the past the use of the term hypernephroma has been criticised; however, this term serves as well as any other to designate the type of renal tumor that has certain biologic and histological characteristics. According to McDonald,<sup>1</sup>Bell,<sup>2</sup>and others, small adenomas are precursors of hypernephroma. They occur frequently in the renal parenchyma, but only after they have increased in size to approximately 3.5 cc. or larger do they
<i>QuickStats</i>: Percentage* of Emergency Department Visits for Acute Viral Upper Respiratory Tract Infection† That Had an Antimicrobial Ordered or Prescribed,§ by Metropolitan Statistical Area¶ — United States, 2008–2015**
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

From 2008-2011 to 2012-2015, the percentage of visits for acute viral upper respiratory tract infection that had an antimicrobial ordered or prescribed decreased from 37.1% to 25.5% among emergency departments (EDs) located in nonmetropolitan statistical areas, but this decline was not seen among EDs in metropolitan statistical areas. In 2008-2011, the percentage was higher among nonmetropolitan EDs than metropolitan EDs, but there was no difference in 2012-2015.
Diffuse Collagen Disease
Authors: Paul Klemperer
Journal: JAMA (1984)

The thesis of Morgagni that diseases reside in certain organs of the human body has dominated pathologic anatomy and clinical investigation for centuries. Every diagnostic endeavor was directed toward establishing the fundamental organ disease. No doubt, this working hypothesis has been the cornerstone on which rests the edifice of modern medicine. The great advance of medicine throughout the nineteenth century is essentially founded on the method of correlating observations made in the hospital ward with those at the postmortem table. This clinicopathologic concept was further advanced by the recognition of an interdependence and unity of certain organs to form organ or tissue systems. Diseases of the hemopoietic or of the reticuloendothelial system represent such an extension of the scope of organ pathology. Nevertheless, one cannot justly maintain that an essential site is established in every disease. A number of acute infections and intoxications do not produce characteristic or even significant
Cell Lineage in the Development of Invertebrate Nervous Systems
Authors: G. Stent
Journal: Annual Review of Neuroscience (1985)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More