POS1519-HPR IMPACT OF SYSTEMIC LUPUS ERYTHEMATOSUS ON FOOT FUNCTION, PAIN, AND ASSOCIATED DISABILITY.
Authors: L. Cano Garcia, J. Marco-Lledó, N. Al Mashhadani, A. M. Cabezas-Lucena, M. Morales-Águila, J. García-Campos
Journal: Annals of the Rheumatic Diseases (2022)

Background Systemic lupus erythematosus (SLE) is an inflammatory pathology of autoimmune origin with high morbidity and a great impact on daily life. Hindfoot pain is often an area of ​​the musculoskeletal system that is severely affected and causes walking difficulties. The alterations in the structure and posture of the foot can contribute to altered gait patterns in people with SLE, reducing health-related quality of life. Objectives This work’s objective was to know the impact of SLE on pain, disability, activity limitation, foot function in activities of daily living and life quality. Methods The study of the population included people with SLE. A cross-sectional observational study was carried out. 47 subjects with a diagnosis of SLE recruited in a Rheumatology Unit between March and May 2021 were included. The inclusion criteria were: patients with a diagnosis of SLE according to the EULAR / ACR 2019 criteria11, and a diagnosis of at least one year of evolution and age equal to or greater than 18 years. Sociodemographic, clinical and therapeutic data were collected. Cumulative damage was measured using the Systemic Lupus International Collaborating Clinics Damage Index (SLICC) and disease activity using the Systemic Lupus Erythematosus Disease Activity Measure (SLEDAI). Pain, disability and activity limitation were assessed using the Foot Function Index (FFI) scale where higher scores indicate greater pain, disability, and activity limitation and therefore poorer foot health. Pain nowadays was also measured using the Visual Analog Pain Scale (EVAD), foot function was assessed using the Foot and Ankle Ability Measures (FAAM) scale for activities of daily living (FAAM-ADL) and for physical activity (FAAM-S) where higher scores indicate higher levels of function, and perceived health-related quality of life was evaluated through the EUROQoL-5D scale where higher scores indicates poorer quality of life. Results 47 subjects participated (93.6% women) with a mean age (SD) of 49.2 (10.8) years (range 23-66). The mean (SD) SLICC and SLEDAI scores were 0.74 (1.33) and 1.17 (1.80), respectively. Mean foot pain was 4.38 (SD 2.97) on a VAS of 10 at the current time. The mean overall score (SD) on the FFI was 37.08 (26.41). The FAAM score on the ADL subscale was 0.64 (0.234). Of a total of 31 subjects who reported that they practiced some type of physical activity, the mean score (SD) on the Sport subscale of the FAAM was 0.51 (0.30). Regarding the quality of life measured through the EQ5D, a mean score (SD) of 0.56 (0.25) was obtained. In addition, a mean score (SD) of 63.76 (23.40) was obtained on the EVAEQ5D. A significant association was only obtained between SLICC and the overall value of the FFI (r = 0.305; p = 0.037), where the less accumulated damage, the less impact of foot problems on pain, disability and activity limitation. There was no significant correlation between the SLEDAI and the FFI, FAAM and ED5D. Conclusion The foot’s function is moderately affected and a third of the patients evaluated are unable to carry out any physical activity, despite having low activity of the disease measured by SLEDAI. Furthermore, we found a direct correlation of the damage measured by SLICC-DI with problems of pain, disability and limitation in activity related with the foot. Disclosure of Interests None declared