tbuckley/cabot-search huggingface dataset:
Effects of azithromycin and doxycycline on the vaginal microbiota of women with urogenital Chlamydia trachomatis infection: a substudy of the Chlazidoxy randomized controlled trial
Authors: Jeanne Tamarelle, Benjamin Penaud, Benjamin Tyssandier, Erwan Guichoux, Bertille de Barbeyrac, Olivia Peuchant, Dounia Baita, Catherine Ouziel-Duretz, Béatrice Poudens, Raquel Brun, Sophie Jouvert, Aurore Tesson, Jennifer Carrière, Marie Diaz, Camille Forget, Isabelle Le Hen, France Ahano-Ducourneau, Delphine Ha Van, Pauline Robert, Fabienne Brun, Estelle Lhospital, Julie Bardou, Annaïg Guegan, Sandy Ramloll Moura, Céline Leriche, Alix De Cussy, Marlène Malfait, Charlotte Rychen, Pervenche Martinet, Audrey Kugeler, Lisa Barriere, Laura Gutierrez, Jean-Luc Robert, Julie Saule, Viviana Bergamaschi, Sana Ben Soltana, Dominique Aymar-Moulene, Claire Bernier, Anne-Sophie Lecompte, Antoine Gregoire, Thomas Girard, Marie-Astrid Naccache, Philippe Lefebvre, Pauline Crombe, Christine Bulot, Anne-Laure Rolland, Katy Dernivoix, Camille Trouillet, Nathalie Trignol-Viguier, Elisabeth Blin-Zbiegiel, Mélanie Boissinot, Bruno Joly, Anne Dubreuil, Camille Mathieu, David Pragout, Cécile Bébéar, Anne Grob, Sophie Zaffreya, Erwan Le Naour, Anne Sophie Gibaud, Philippe Lanotte, Anne Vachée, Julien Loubinoux, Arabella Touati, Carla Balcon, Caroline Roussillon, Bellabes Ghezzoul, Frédéric Perry, Christelle Turuban, Sabine Rapin, Christine Pastor, Morane Cavellec, Ernesto Paredes Manvri, Sonia Albane, Katy Dernivoix, Camille Trouillet, Eva Ghiringhelli, Karen Pantin, Marion Kret, Edouard Lhomme, Damien Garreau, Jérôme Galet
Journal: Clinical Microbiology and Infection (2023)
Machine learning-based immune phenotypes correlate with STK11/KEAP1 co-mutations and prognosis in resectable NSCLC: a sub-study of the TNM-I trial
Authors: M. Rakaee, S. Andersen, K. Giannikou, E.-E. Paulsen, T.K. Kilvaer, L.-T.R. Busund, T. Berg, E. Richardsen, A.P. Lombardi, E. Adib, M.I. Pedersen, M. Tafavvoghi, S.G.F. Wahl, R.H. Petersen, A.L. Bondgaard, C.W. Yde, C. Baudet, P. Licht, M. Lund-Iversen, B.H. Grønberg, L. Fjellbirkeland, Å. Helland, M. Pøhl, D.J. Kwiatkowski, T. Donnem
Journal: Annals of Oncology (2023)

We aim to implement an immune cell score model in routine clinical practice for resected non-small-cell lung cancer (NSCLC) patients (NCT03299478). Molecular and genomic features associated with immune phenotypes in NSCLC have not been explored in detail.We developed a machine learning (ML)-based model to classify tumors into one of three categories: inflamed, altered, and desert, based on the spatial distribution of CD8+ T cells in two prospective (n = 453; TNM-I trial) and retrospective (n = 481) stage I-IIIA NSCLC surgical cohorts. NanoString assays and targeted gene panel sequencing were used to evaluate the association of gene expression and mutations with immune phenotypes.Among the total of 934 patients, 24.4% of tumors were classified as inflamed, 51.3% as altered, and 24.3% as desert. There were significant associations between ML-derived immune phenotypes and adaptive immunity gene expression signatures. We identified a strong association of the nuclear factor-κB pathway and CD8+ T-cell exclusion through a positive enrichment in the desert phenotype. KEAP1 [odds ratio (OR) 0.27, Q = 0.02] and STK11 (OR 0.39, Q = 0.04) were significantly co-mutated in non-inflamed lung adenocarcinoma (LUAD) compared to the inflamed phenotype. In the retrospective cohort, the inflamed phenotype was an independent prognostic factor for prolonged disease-specific survival and time to recurrence (hazard ratio 0.61, P = 0.01 and 0.65, P = 0.02, respectively).ML-based immune phenotyping by spatial distribution of T cells in resected NSCLC is able to identify patients at greater risk of disease recurrence after surgical resection. LUADs with concurrent KEAP1 and STK11 mutations are enriched for altered and desert immune phenotypes.
Car-following crash risk analysis in a connected environment: A Bayesian non-stationary generalised extreme value model
Authors: Faizan Nazir, Yasir Ali, Anshuman Sharma, Zuduo Zheng, Md Mazharul Haque
Journal: Analytic Methods in Accident Research (2023)

A connected environment provides driving aids to assist drivers in decision-making and aims to make driving manoeuvres safer by minimising uncertainty associated with decisions. The role of a connected environment becomes vital for car-following manoeuvres in a safety–critical event, whereby drivers follow a lead vehicle, and if timely action is not taken, it is likely to lead to a rear-end collision. Moreover, how different drivers perceive and react to the same information needs to be explored to understand the differential effects of a connected environment on car-following behaviour. As such, this study investigated the effects of the traditional and connected environments on car-following crash risk using traffic conflict techniques. Data were collected using the CARRS-Q advanced driving simulator, whereby 78 participants performed a car-following task in two randomised driving conditions: baseline (without driving aids) and connected environment (with driving aids). The safety–critical event in the car-following scenario was the leader's hard braking, for which participants received advance information, besides several other driving aids. Modified time-to-collision was used as the traffic conflict measure for characterising rear-end crash risk and modelled using a generalised extreme value (GEV) model in the Bayesian framework. This model incorporated driving-related factors and driver demographics to address the non-stationarity issue of traffic extremes. Results reveal that the car-following crash risk is significantly reduced in the connected environment. Further, using the developed model, separate GEV distributions were estimated for each individual driver, providing insights into the heterogeneous effects of the connected environment on crash risk. The developed model was employed to understand the crash risk across different driver characteristics, and results suggest that crash risk decreases for all age groups and gender, with the maximum safety benefits obtained by young and female drivers. The findings of this study shed light on the efficacy of the connected environment in improving car-following behaviour and drivers' ability to make safer decisions.
Aerosol pulmonary immune engineering
Authors: Emma R. Sudduth, Michael Trautmann-Rodriguez, Nicole Gill, Kartik Bomb, Catherine A. Fromen
Journal: Advanced Drug Delivery Reviews (2023)

Aerosolization of immunotherapies poses incredible potential for manipulating the local mucosal-specific microenvironment, engaging specialized pulmonary cellular defenders, and accessing mucosal associated lymphoid tissue to redirect systemic adaptive and memory responses. In this review, we breakdown key inhalable immunoengineering strategies for chronic, genetic, and infection-based inflammatory pulmonary disorders, encompassing the historic use of immunomodulatory agents, the transition to biological inspired or derived treatments, and novel approaches of complexing these materials into drug delivery vehicles for enhanced release outcomes. Alongside a brief description of key immune targets, fundamentals of aerosol drug delivery, and preclinical pulmonary models for immune response, we survey recent advances of inhaled immunotherapy platforms, ranging from small molecules and biologics to particulates and cell therapies, as well as prophylactic vaccines. In each section, we address the formulation design constraints for aerosol delivery as well as advantages for each platform in driving desirable immune modifications. Finally, prospects of clinical translation and outlook for inhaled immune engineering are discussed.
Author Correction: SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy
Authors: Xingyu Li, Peili Hou, Wenqing Ma, Xuefeng Wang, Hongmei Wang, Zhangping Yu, Huasong Chang, Tiecheng Wang, Song Jin, Xue Wang, Wenqi Wang, Yudong Zhao, Yong Zhao, Chunqing Xu, Xiaomei Ma, Yuwei Gao, Hongbin He
Journal: Cellular and Molecular Immunology (2023)
Multistage‐Responsive Dual‐Enzyme Nanocascades for Synergistic Radiosensitization‐Starvation Cancer Therapy
Authors: Ming Zhao, Anni Zhu, Xueyun Zheng, Xiaomin Qian, Shujun Zhang, Chenyu Wu, Congwei Yu, Jiaheng Zhang, Jingchao Li
Journal: Advanced Healthcare Materials (2023)

Abstract Radiotherapy is a common cancer treatment approach in clinical practice, yet its efficacy has been restricted by tumor hypoxia. Nanomaterials‐mediated systemic delivery of glucose oxidase (GOx) and catalase (CAT) or CAT‐like nanoenzymes holds the potential to enhance tumor oxygenation. However, they face the challenge of intermediate (hydrogen peroxide [H 2 O 2 ]) escape during systemic circulation if the enzyme pair is not closely placed to largely decompose H 2 O 2 , leading to oxidative stress on normal tissues. In the present study, a oxygen‐generating nanocascade, n(GOx‐CAT) C7A , constructed by strategically placing an enzymatic cascade (GOx and CAT) within a polymeric coating rich in hexamethyleneimine (C7A) moieties, is reported. During blood circulation, C7A remains predominantly non‐protonated , achieving prolonged blood circulation due to its low‐fouling surface. Once n(GOx‐CAT) C7A reaches the tumor site, the acidic tumor microenvironment (TME) induces protonation of C7A moieties, resulting in a positively charged surface for enhanced tumor transcytosis. Moreover, GOx and CAT are covalently conjugated into close spatial proximity (&lt;10 nm) for effective H 2 O 2 elimination. As demonstrated by the in vivo results, n(GOx‐CAT) C7A achieves effective tumor retention and oxygenation, potent radiosensitization and antitumor effects. Such a dual‐enzyme nanocascade for smart O 2 delivery holds great potential for enhancing the hypoxia‐compromised cancer therapies.
Annals Story Slam - Personal Experience Buying a Gun
Authors: Amir Richardson
Journal: Annals of Internal Medicine (2023)

Web ExclusivesMay 2023Annals Story Slam - Personal Experience Buying a GunFREEAmir RichardsonAmir RichardsonSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W23-0010 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - Personal Experience Buying a Gun "Personal Experience Buying a Gun," by Amir Richardson. (Duration 5:02)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam.This story was shared at the “Gun Injury: Stories of Hurt, Hope, and Resilience” Story Slam event, held at WHYY in Philadelphia on 7 December 2022. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAuthors: Amir RichardsonThis article was published at Annals.org on 25 April 2023. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Current IssueMay 2023Volume 176, Issue 5 ePublished: 25 April 2023 Issue Published: May 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.Loading ...
Molecular MR Imaging of Renal Fibrogenesis in Mice
Authors: Yin-Ching Chen, Philip A. Waghorn, Ivy A. Rosales, Gunisha Arora, Derek J. Erstad, Nicholas J. Rotile, Chloe M. Jones, Diego S. Ferreira, Lan Wei, Robert V.P. Martinez, Franklin J. Schlerman, Jeremy Wellen, Bryan C. Fuchs, Robert B. Colvin, Ilknur Ay, Peter Caravan
Journal: Journal of the American Society of Nephrology (2023)

Background In most CKDs, lysyl oxidase oxidation of collagen forms allysine side chains, which then form stable crosslinks. We hypothesized that MRI with the allysine-targeted probe Gd-oxyamine (OA) could be used to measure this process and noninvasively detect renal fibrosis. Methods Two mouse models were used: hereditary nephritis in Col4a3-deficient mice (Alport model) and a glomerulonephritis model, nephrotoxic nephritis (NTN). MRI measured the difference in kidney relaxation rate, ΔR1, after intravenous Gd-OA administration. Renal tissue was collected for biochemical and histological analysis. Results ΔR1 was increased in the renal cortex of NTN mice and in both the cortex and the medulla of Alport mice. Ex vivo tissue analyses showed increased collagen and Gd-OA levels in fibrotic renal tissues and a high correlation between tissue collagen and ΔR1. Conclusions Magnetic resonance imaging using Gd-OA is potentially a valuable tool for detecting and staging renal fibrogenesis.
Annals Story Slam - Being Ready
Authors: Elinore Kaufman
Journal: Annals of Internal Medicine (2023)

Web ExclusivesMay 2023Annals Story Slam - Being ReadyFREEElinore Kaufman, MD, MSHPElinore Kaufman, MD, MSHPSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W23-0005 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - Being Ready "Being Ready," by Elinore Kaufman, MD, MSHP. (Duration 6:07)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam.This story was shared at the “Gun Injury: Stories of Hurt, Hope, and Resilience” Story Slam event, held at WHYY in Philadelphia on 7 December 2022. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAuthors: Elinore Kaufman, MD, MSHPThis article was published at Annals.org on 25 April 2023. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Current IssueMay 2023Volume 176, Issue 5 ePublished: 25 April 2023 Issue Published: May 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.Loading ...
Annals Story Slam - Co-Victims of Gun Violence
Authors: Cherisse Pearson
Journal: Annals of Internal Medicine (2023)

Web ExclusivesMay 2023Annals Story Slam - Co-Victims of Gun ViolenceFREECherisse PearsonCherisse PearsonSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W23-0004 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - Co-Victims of Gun Violence "Co-Victims of Gun Violence," by Cherisse Pearson. (Duration 7:51)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam.This story was shared at the “Gun Injury: Stories of Hurt, Hope, and Resilience” Story Slam event, held at WHYY in Philadelphia on 7 December 2022. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAuthors: Cherisse PearsonThis article was published at Annals.org on 25 April 2023. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics May 2023Volume 176, Issue 5 ePublished: 25 April 2023 Issue Published: May 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.Loading ...
Gold‐Enhanced Brachytherapy by a Nanoparticle‐Releasing Hydrogel and 3D‐Printed Subcutaneous Radioactive Implant Approach
Authors: Mariia Kiseleva, Théophraste Lescot, Svetlana V. Selivanova, Marc‐André Fortin
Journal: Advanced Healthcare Materials (2023)

Brachytherapy (BT) is a widely used clinical procedure for localized cervical cancer treatment. In addition, gold nanoparticles (AuNPs) have been demonstrated as powerful radiosensitizers in BT procedures. Prior to irradiation by a BT device, their delivery to tumors can enhance the radiation effect by generating low-energy photons and electrons, leading to reactive oxygen species (ROS) production, lethal to cells. No efficient delivery system has been proposed until now for AuNP topical delivery to localized cervical cancer in the context of BT. This article reports an original approach developed to accelerate the preclinical studies of AuNP-enhanced BT procedures. First, an AuNP-containing hydrogel (Pluronic F127, alginate) is developed and tested in mice for degradation, AuNP release, and biocompatibility. Then, custom-made 3D-printed radioactive BT inserts covered with a AuNP-containing hydrogel cushion are designed and administered by surgery in mice (HeLa xenografts), which allows for measuring AuNP penetration in tumors (≈100 µm), co-registered with the presence of ROS produced through the interactions of radiation and AuNPs. Biocompatible AuNPs-releasing hydrogels could be used in the treatment of cervical cancer prior to BT, with impact on the total amount of radiation needed per BT treatment, which will result in benefits to the preservation of healthy tissues surrounding cancer.
Annals Story Slam - Code on the 9th Floor
Authors: Gillian Naro
Journal: Annals of Internal Medicine (2023)

Web ExclusivesMay 2023Annals Story Slam - Code on the 9th FloorFREEGillian Naro, MDGillian Naro, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W23-0008 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - Code on the 9th Floor "Code on the 9th Floor," by Gillian Naro, MD. (Duration 6:02)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam.This story was shared at the “Gun Injury: Stories of Hurt, Hope, and Resilience” Story Slam event, held at WHYY in Philadelphia on 7 December 2022. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAuthors: Gillian Naro, MDThis article was published at Annals.org on 25 April 2023. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Current IssueMay 2023Volume 176, Issue 5 ePublished: 25 April 2023 Issue Published: May 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.Loading ...
Annals Story Slam - Second Victim Syndrome
Authors: Michelle Romeo
Journal: Annals of Internal Medicine (2023)

Web ExclusivesMay 2023Annals Story Slam - Second Victim SyndromeFREEMichelle Romeo, MDMichelle Romeo, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W23-0003 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - Second Victim Syndrome "Second Victim Syndrome," by Michelle Romeo, MD. (Duration 6:11)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam.This story was shared at the “Gun Injury: Stories of Hurt, Hope, and Resilience” Story Slam event, held at WHYY in Philadelphia on 7 December 2022. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAuthors: Michelle Romeo, MDThis article was published at Annals.org on 25 April 2023. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Current IssueMay 2023Volume 176, Issue 5 ePublished: 25 April 2023 Issue Published: May 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.Loading ...
Bone Loss in Inflammatory Rheumatic Musculoskeletal Disease Patients Treated With <scp>Low‐Dose</scp> Glucocorticoids and Prevention by <scp>Anti‐Osteoporosis</scp> Medications
Authors: Giovanni Adami, Angelo Fassio, Maurizio Rossini, Camilla Benini, Francesca Pistillo, Ombretta Viapiana, Davide Bertelle, Davide Gatti
Journal: Arthritis & Rheumatology (2023)

The negative effects of glucocorticoids on bone depend on dose and treatment duration. However, it is unclear whether a safe dose exists, especially for patients with inflammatory rheumatic musculoskeletal diseases (iRMDs). We undertook this study to determine the effects of glucocorticoid doses on bone health in iRMD patients.We conducted a longitudinal cohort study on women with iRMD. Bone mineral density (BMD) and fractures were assessed prospectively and compared to a matched cohort without iRMD. Kaplan-Meier curves with log rank test were made for iRMD patients (stratified for glucocorticoid use and dose) and the matched cohort. Multivariable Cox regression survival models were also employed to analyze the effect of glucocorticoids on fracture.A total of 884 women with iRMD and 1,766 controls (matched for age, T score, and 10-year fracture risk) were included in the study and followed up for up to 6 years. BMD decreased significantly in all patients receiving glucocorticoids who were not receiving anti-osteoporosis treatment (-4.26% for ≥5 mg/day of prednisone equivalent, P = 0.0011; -4.23% for 2.5-5 mg/day, P = 0.0422; -2.66% for 0-2.5 mg/day, P = 0.0006). Anti-osteoporosis treatment (largely bisphosphonates) prevented bone loss only in patients receiving <5 mg/day of prednisone equivalent. Fracture incidence was higher in patients with iRMD compared to controls, but only glucocorticoid doses ≥5 mg/day were associated with significantly higher risk of fracture.Glucocorticoid doses as low as 2.5 mg/day were associated with BMD loss in iRMD patients, but this effect was preventable. BMD loss in patients receiving ≥5 mg/day was not totally prevented by anti-osteoporosis medications currently used in clinical practice, resulting in higher risk of fracture.
Annals Story Slam - Helping Navigate the Judicial System
Authors: Rodney Babb
Journal: Annals of Internal Medicine (2023)

Web ExclusivesMay 2023Annals Story Slam - Helping Navigate the Judicial SystemFREERodney BabbRodney BabbSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W23-0011 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - Helping Navigate the Judicial System "Helping Navigate the Judicial System," by Rodney Babb. (Duration 4:24)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam.This story was shared at the “Gun Injury: Stories of Hurt, Hope, and Resilience” Story Slam event, held at WHYY in Philadelphia on 7 December 2022. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAuthors: Rodney BabbThis article was published at Annals.org on 25 April 2023. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics May 2023Volume 176, Issue 5 ePublished: 25 April 2023 Issue Published: May 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.Loading ...