tbuckley/cabot-search huggingface dataset:
FEDERAL AID TO MEDICAL EDUCATION
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immune Response to Gross Virus-Induced Lymphoma. III. Characteristics of the Cellular Immune Response
Authors: Ortiz de Landazuri, Manuel, Herberman, Ronald B.
Journal: JNCI Journal of the National Cancer Institute (1972)

Journal Article Immune Response to Gross Virus-Induced Lymphoma. III. Characteristics of the Cellular Immune Response Get access Manuel Ortiz de Landazuri, Manuel Ortiz de Landazuri Cellular and Tumor Immunology Section, Laboratory of Cell Biology, National Cancer Institute,4Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar Ronald B. Herberman Ronald B. Herberman 3 Cellular and Tumor Immunology Section, Laboratory of Cell Biology, National Cancer Institute,4Bethesda, Maryland 20014 3Address reprint requests to Dr. R. B. Herberman. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 49, Issue 1, July 1972, Pages 147–154, https://doi.org/10.1093/jnci/49.1.147 Published: 01 July 1972 Article history Received: 07 January 1972 Accepted: 14 March 1972 Published: 01 July 1972
Relevance and Utility of Courses in Medical Ethics
Authors: Edmund D. Pellegrino
Journal: JAMA (1985)

In the last decade the teaching of medical ethics has become almost universal in American medical schools. Its effectiveness is, however, just beginning to be evaluated. A stratified random sample of 3,000 practicing physicians who were graduated between 1974 and 1978 was surveyed to evaluate their perceptions of the utility and relevance of medical ethics teaching. Those who had courses in medical ethics perceived it to be of substantial benefit in confronting the actual ethical issues they encountered in daily practice. They favored the continuation and expansion of the teaching of medical ethics and had suggestions for its improvement. Data were also obtained on the relative frequency of specific ethical issues in practices and on the relative influence of home, personal values, medical education, medical practice, and ethics courses on respondents' approaches to ethical issues. (<i>JAMA</i>1985;253:49-53)
A Field Trial of Inactivated Measles Virus Vaccine in Young School Children
Authors: Warren Winkelstein
Journal: JAMA (1965)

A concentrated, alum-containing, formalin-inactivated measles virus vaccine was evaluated in a double-blind field trial conducted in young school children. Vaccine was administered at random to 296 five- and six-year olds and placebo to 286. The dosage schedule consisted of three intramuscular injections of 0.5 ml of vaccine or placebo at intervals of one and three weeks. Measles was prevalent in the study population during the immunization period and for three months thereafter as well as from the 18th through the 27th months of follow-up. During the immediate postvaccir ation challenge vaccine effectiveness was estimated at 94% while during the late postimmunization challenge, effectiveness had declined to 57%. Nevertheless, during the latter period, the proportion of mild cases was considerably higher among vaccinees than controls.
Bronchial Hyperresponsiveness
Authors: Jon Ayres
Journal: Thorax (1987)

Epidemiology of sarcoidosis in the Isle of Man SIR,-Dr SB de C Baker and his team on the Isle of Man are to be congratulated on an excellent epidemiological analysis of sarcoidosis on the island (June 1987;42:420-30).The inference of their work is that there is a communicable factor as a result of prolonged close contact.This is analogous to tuberculosis, where close and lengthy contact with a source case increases the risk of an individual's developing the disease.However, their work does not rule out a common response to one or more other causative or contributory environmental factors shared by the cases.Indeed, the remarkable lack of cases occurring in married couples would point to a work (or non-domestic) related environmental factor, although what this might be is open to conjecture.One factor which has not apparently been analysed is the possible effect of cigarette smoking.Is there any evidence that sarcoidosis patients were more likely to be cigarette smokers than non-tuberculosis controls?If so, was there any pattern in the linked cases as regards cigarette smokingthat is, did some "linked groups" smoke while others did not?If the latter were true, this would point to different causative agents being responsible in different groups, cigarette smoking being a permissive factor.
Suicide and the use of antidepressants Drug treatment of depression is inadequate
Authors: E Isometsa, M Henriksson, M Heikkinen, H Aro, J Lonnqvist, A Owen, T O'Hare, H Goode, K Matthews, G Isacsson, P Holmgren, D Wasserman, U Bergman
Journal: BMJ (1994)

Suicide and the use of antidepressants Drug treatment ofdepression is inadequate EDrroR,-Goran Isacsson and colleagues suggest that therapeutic failure of antidepressant drugs may be a greater problem in people who commit suicide than toxicity in overdose as their results indicated no advantage of the newer, less toxic drugs; furthermore, their results confirmed that only a small minority of people who commit suicide have received antidepressant treatment before death despite the high prevalence of depression in the population.'The notable problems in their otherwise impressive database were, however, that they had neither diagnostic information nor knowledge of the dosage used in the cases studied.As our work may contribute to these questions,2 we wish to confirm and extend their findings.In the national suicide prevention project in Finland all suicides (n-1397) in Finland committed between 1 April 1987 and 31 March 1988 were comprehensively examined by the psychological necropsy method.Mental disorders were evaluated retrospectively, according to the criteria in the Diagnostic and Statistical Manual of Mental, Disorders, third edition, revised, in a diagnostic study of a random sample of 229 suicides.'In this study 71 of the 229 people who had committed
Nervous and Mental Diseases.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endoscopy International Open – recently published
Journal: Endoscopy (2018)

Comment on: Radiofrequency ablation (RFA) vs. argon plasma coagulation (APC) for the management of gastric antral vascular ectasia (GAVE) in patients with and without cirrhosis: results from a retrospective analysis of a large cohort of patients treated at a single centerEndosc Int Open 2018; 06(03): E266-E270DOI: 10.1055/s-0043-123187 Comment on: Endoscopic necrosectomy of walled-off pancreatic necrosis by large-bore percutaneus metal stent: a new opportunity?Endosc Int Open 2018; 06(03): E274-E278DOI: 10.1055/s-0043-125313 Comment on: Effective and less invasive diagnostic strategy for gastrointestinal GVHDEndosc Int Open 2018; 06(03): E281-E291DOI: 10.1055/s-0043-122226
The Psychological Lesson of Hiroshima and Nagasaki
Authors: Robert Bingham
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The bombs dropped on Hiroshima and on Nagasaki have created a great deal of negative criticism of our government, and it is worthwhile to look at them from another point of view. About the first of September 1945,I believe I was the first US Army physician to visit the atom bomb site in Nagasaki. Our team spent about a half hour at "ground zero." (We were unaware of radiation exposure to which we were being subjected.) Later we visited with Japanese officials and doctors and had the opportunity of photographing victims who remained in local hospitals. We drove in our jeep through the debris of five-story aircraft factory buildings that had been crushed to a height of 10 ft. Thousands of bodies were beneath the rubble. (The stench of death was so strong that it was several days before we could push it from our thoughts.) Surrounding
Radioactive Fallout and Cancer
Authors: Joseph L. Lyon
Journal: JAMA (1984)

<h3>To the Editor.—</h3> The study by Dr Carl Johnson<sup>1</sup>quoted our work out of context<sup>2</sup>to support the accuracy of his method of identifying cancer cases among those exposed to radioactive fallout. Johnson used community volunteers to interview self-selected heads of families to ascertain each cancer in family members over the preceding 30 years. The interview was conducted after the families had viewed an antinuclear television documentary entitled "Paul Jacobs and the Nuclear Gang," which strongly suggested that fallout had caused cancers in persons living downwind (<i>Salt Lake Tribune</i>, Aug 30, 1981, p A17). Johnson cited us to support the accuracy of his case-finding method to the effect that "diagnosis in life correlated with death certificate cause and with unpublished data from the Utah Cancer Registry more than 90% of the time." This is taken out of context. The full quote reads, "<i>The cases of leukemia included in this</i>
A Portable Electrocardiographic Screening Device
Authors: David Christie
Journal: JAMA (1973)

We evaluated the Electro-Cardio-Analyzer (ECA), which is a portable electronic device designed for mass electrocardiographic screening. Its verdicts have been compared with those of conventional electrocardiography in a series of 2,595 middle-aged men who were examined in factory medical departments. Among 117 with reported ischemic-type abnormalities in the electrocardiogram, 88% were correctly identified by the ECA; in most instances, the undetected changes were of debatable clinical importance. The false-positive rate varied according to the particular circumstances in which the instrument was used, emphasizing the need for careful standardization of screening procedures. If mass electrocardiographic screening is adopted for the early detection of coronary heart disease, the ECA may find an application in reducing the load on conventional electrocardiographic services.
Tolonium (Toluidine Blue) Rinse—A Screening Method for Recognition of Squamous Carcinoma
Authors: Arthur Mashberg
Journal: JAMA (1981)

Tolonium chloride (toluidine blue) application is useful for identifying malignant changes in squamous mucosa. However, early asymptomatic mucosal changes may remain undetected by tolonium application. A study was carried out to determine the feasibility of using a tolonium mouth rinse as a routine procedure after thorough clinical examination, to discover undetected cancers. A proved, effective tolonium application method was compared with a rinse sequence. One hundred five asymptomatic oral lesions (51 carcinomas and 54 nonmalignant lesions) that persisted for ten to 14 days were evaluated with application and rinse modalities and biopsies. There were 2% false-negatives (1/51) with the application as opposed to 5.9% (3/51) with the rinse and 9.3% false-positives (5/54) with the application as compared to 7.4% (4/54) with the rinse. Four inapparent, second primary cancers, unobserved for application, were delineated by the rinse (three oral, one pharyngeal). Tolonium blue rinse may be used to detect unobserved, asymptomatic oral mucosal cancers after clinical examination. After a positive rinse stain, a subsequent positive application stain ten to 14 days later mandates a biopsy of the lesion. (<i>JAMA</i>1981;245:2408-2410)
The experimental use of psychedelic (LSD) psychotherapy
Authors: W. N. Pahnke
Journal: JAMA (1970)

The history of research with psychedelic drugs has produced a variety of methods for their use and conflicting claims about results. First came the wave of excitement among experimentalists in the 1950s when it was claimed that lysergic acid diethylamide (LSD) could produce a model psychosis which might be useful in understanding schizophrenia. While this promise was fading, enthusiastic reports about the possibility of LSD as an aid to psychotherapy in the treatment of alcoholism and other psychiatric disorders appeared. All these approaches were represented in 1959 at the first international conference devoted entirely to LSD.<sup>1</sup>Since then, there have been at least five more published proceedings of such conferences on various aspects of psychedelic drugs.<sup>2-6</sup>The most recent conference on various means of producing states of consciousness was sponsored by the Menninger Foundation and the American Association of Humanistic Psychology on April 7 to 11, 1969, in
BLOOD PRESSURE IN EARLY LIFE
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Carcinogenicity of Epoxides, Lactones, and Peroxy Compounds. VI. Structure and Carcinogenic Activity&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: Van Duuren, B. L., Langseth, L., Goldschmidt, B. M., Orris, L.
Journal: JNCI Journal of the National Cancer Institute (1967)

Journal Article Carcinogenicity of Epoxides, Lactones, and Peroxy Compounds. VI. Structure and Carcinogenic Activity Get access B. L. Van Duuren, B. L. Van Duuren Laboratory of Organic Chemistry and Carcinogenesis, Institute of Environmental Medicine, New York University Medical Center, New York, New York 10016 Search for other works by this author on: Oxford Academic PubMed Google Scholar L. Langseth, L. Langseth Laboratory of Organic Chemistry and Carcinogenesis, Institute of Environmental Medicine, New York University Medical Center, New York, New York 10016 Search for other works by this author on: Oxford Academic PubMed Google Scholar B. M. Goldschmidt, B. M. Goldschmidt Laboratory of Organic Chemistry and Carcinogenesis, Institute of Environmental Medicine, New York University Medical Center, New York, New York 10016 Search for other works by this author on: Oxford Academic PubMed Google Scholar L. Orris L. Orris Laboratory of Organic Chemistry and Carcinogenesis, Institute of Environmental Medicine, New York University Medical Center, New York, New York 10016 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 39, Issue 6, December 1967, Pages 1217–1228, https://doi.org/10.1093/jnci/39.6.1217 Published: 01 December 1967 Article history Received: 17 May 1967 Published: 01 December 1967
Effects of Polychlorinated Biphenyls on Lung and Liver Tumors Initiated in Suckling Mice by &lt;italic&gt;N&lt;/italic&gt;-Nitrosodimethylamine&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1983)

A mixture of polychlorinated biphenyls (PCB), Aroclor 1254, was administered ip (500 mg/kg) to pregnant Swiss noninbred CD-1 mice on the 19th day of gestation. The suckling offspring of these mice and of controls were then treated ip with 5 mg N-nitrosodimethylamine (DMN)/kg on postnatal day 4 or day 14. The progeny were killed at 28 weeks or 18 months of age. The DMN treatment caused lung and liver tumors. Among the mice given DMN on day 14, exposure also to PCB resulted in a lower tumor incidence in some of the treatment groups. This protective action was most evident for lung tumors in both sexes at 18 months of age and for liver tumors in males at 28 weeks. However, the PCB exposure also led to significant increases in the percentage of mice with extensive DMN-initiated liver tumors at 18 months of age compared to the results obtained when only DMN was given. This effect was most pronounced in mice given DMN on postnatal day 4.
Tests for Respiratory Efficiency
Journal: JAMA (1935)

The demand for clinical and laboratory methods for quantitative evaluation of functional efficiency of organs or systems is in ever increasing demand. Both surgeon and physician desire to assess the degree of impairment with which they have to deal. In this monograph the author sets forth in a concise manner the various methods employed in testing respiratory efficiency. He concludes that no one test can be relied on and that in order to gain a useful estimate of respiratory function the patient's vital capacity, ventilating efficiency and expiratory force must all be studied. The author does not settle the question, but his work is critical and stimulating. It will be read with interest by all those interested in estimating the efficiency of the respiratory apparatus. The report will be of special interest to those engaged in insurance work and those concerned with passing on the medical qualifications of individuals in
Role of Partial Nephrectomy in Solitary or Bilateral Renal Tumors
Authors: John M. Palmer
Journal: JAMA (1983)

Partial nephrectomy was carried out successfully in seven of eight cases of solitary or bilateral renal carcinoma. Although three patients with bilateral sequential lesions died of subsequent metastatic disease, their deaths occurred after 33 to 52 months of productive life without the need for end-stage treatment of renal disease. One patient died free of disease of myocardial infarction at 45 months, and the remaining three were alive without evidence of tumor 62, 76, and 85 months after the procedure. No patient suffered local recurrence of tumor, and the need for dialysis in three patients was only temporary. Partial nephrectomy is a viable option in the management of solitary or bilateral renal carcinoma. (<i>JAMA</i>1983;249:2357-2361)
Highlights of This Issue
Journal: Clinical Cancer Research (2015)

Biopsy of metastatic breast cancer (MBC) lesions are recommended to confirm the diagnosis and re-evaluate hormone receptors (HR) and HER2 status. Circulating tumor cells (CTC) might serve as “liquid biopsy,” which could give insight into cancer heterogeneity. Paoletti and colleagues explored the feasibility of performing different markers related to endocrine therapy sensitivity/resistance using the CellSearch assay. They developed a multiparameter CTC-Endocrine Therapy Index (CTC-ETI), which is based on CTC enumeration and a highly validated semiquantitative analysis of CTC-ER, BCL-2, HER2, and Ki67 expression. CTC-ETI may serve as a real-time predictive factor for resistance to ET in patients with HR-positive MBC.In HER2 (+) gastric cancer (GC), although trastuzumab-based chemotherapy is the standard of care, no biomarker for patient selection has been identified. To define the optimal patients who benefit from trastuzumab, Ock and colleagues analyzed the association of HER2/CEP17 ratio and HER2 gene copy number and overall survival (OS) using training set and validation set. In all HER2 (+) GC, patients with HER2/CEP17 ratio ≥ 4.48 showed the better OS. Especially, in patients with HER2 IHC ≤ 2+, HER2/CEP17 ratio ≥ 3.69 conferred the better OS. These findings are helpful for optimal patient selection for trastuzumab in HER2(+) GC.Preconditioning melanoma patients with total body irradiation (TBI) before adoptive transfer of T cells increases objective and curative responses. Bowers and colleagues report the novel mechanism of TBI-induced IL12 secretion by activated dendritic cells, which significantly enhanced the antitumor response of infused Tc17 cells. Further, adding IL12 to Tc17 cultures ex vivo before transfer mimicked effects of TBI by enhancing their function and engraftment in the tumor. Administering low dose IL12 to the mice along with IL12-primed Tc17 cells abrogated the need for TBI — highlighting an alternative to TBI that effectively enhances adoptive immunotherapy for metastatic disease.To unearth the comprehensive genomic landscape of lung adenocarcinoma (LA), Choi and colleagues performed whole exome sequencing for 247 LA patients and discovered 16 novel driver candidates, including COL11A1, CENPF, and SLIT2. They also found that genomic alternations to the RB pathway are strongly linked to a shorter survival outcome for early-stage LA patients. Although the current treatment guideline for early-stage LA patients is composed mainly of follow-up without adjuvant therapy after resection, the current study raises an interesting possibility that additional clinical interventions might provide benefits for early-stage LA patients who have genomic alterations to the RB pathway.