tbuckley/cabot-search huggingface dataset:
Department of Public Health.
Authors: Liston H. Montgomery
Journal: JAMA (1895)

Chicago, Ill., Jan. 22, 1895. <h3>To the Editor:</h3> —It is hoped that the present session of Congress will make suitable provision for substantially carrying out that portion of the President's suggestions embodied in his message in December last, wherein he recommended that a "National Health Bureau be established." And it does not seem that any very great amount of additional argument should be necessary to bring about this important step of legislation. In a few weeks, the present Congress will be "history." Before its<i>demise</i>, it might do something in the way of genuine reform in public health matters, and the well-known maxim, "<i>Salus populi suprema est lex</i>," prevail. If, on the other hand, the present Congress should interpose dilatory objections and pass this measure by, without creating such a branch of our federal government, for obvious reasons it appears to the writer, legislation with the delays liable to occur
Medical News
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1639: CDCP1 cleavage is necessary for homodimerization-induced migration of triple-negative breast cancer
Authors: Heather Wright, Janahan Arulmoli, Maryam Motazedi, Luke Nelson, Olga Razorenova
Journal: Cancer Research (2016)

Abstract Triple negative breast cancer (TNBC) is a highly aggressive and metastatic form of breast cancer that lacks the estrogen, progesterone, and HER2 receptors and is resistant to targeted and hormone therapies. TNBCs express high levels of the transmembrane glycoprotein, CUB-domain containing protein 1 (CDCP1), which has been correlated with the aggressiveness and poor prognosis of multiple carcinomas. Full-length CDCP1 (flCDCP1) can be proteolytically cleaved, resulting in a cleaved membrane-bound isoform (cCDCP1). CDCP1 is phosphorylated by Src family kinases in its full-length and cleaved states, which is important for its pro-metastatic signaling. We observed that cCDCP1, compared to flCDCP1, induced a dramatic increase in phosphorylation of the migration-associated proteins: PKCδ, ERK1/2, and p38 MAPK in HEK 293T. In addition, only cCDCP1 induced migration of HEK 293T cells and rescued migration of the TNBC cell line, MDA-MB-231, expressing shRNA against CDCP1. Importantly, we found that only cCDCP1 is capable of dimerization, which can be blocked by expression of the extracellular portion of cCDCP1 (ECC), indicating that dimerization occurs through CDCP1's ectodomain. We found that ECC inhibited phosphorylation of PKCδ and migration of TNBC cells in 2D culture. Furthermore, ECC induced morphological changes, inhibited proliferation, and stimulated apoptosis of TNBC cells in 3D culture, indicating that the cCDCP1 dimer is an important contributor to TNBC aggressiveness. These studies have important implications for development of a therapeutic to block CDCP1 activity and TNBC metastasis. Citation Format: Heather Wright, Janahan Arulmoli, Maryam Motazedi, Luke Nelson, Olga Razorenova. CDCP1 cleavage is necessary for homodimerization-induced migration of triple-negative breast cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1639.
How do things stand with cisplatin?
Authors: W. Check
Journal: JAMA (1978)

Solid tumors are the nemesis of cancer chemotherapists because they resist the action of many drugs whether given alone or in combination with surgery and radiation therapy: Hence, the growing interest of oncologists and other physicians in the potential of cis-diaminodichloroplatinum (cisplatin), a relatively new experimental agent. Originally demonstrated to be active against disseminated testicular tumors (<i>JAMA</i>MEDICAL NEWS 237:2377 [May 30] 1977), cisplatin now has been shown to be active against several other forms of squamous cell carcinoma. It has produced substantial regression in advanced tumors of the head and neck, genitourinary tract, and lung, and this makes cisplatin, along with doxorubicin hydrochloride, one of the most promising new drugs against solid tumors. Several controlled randomized trials are now under way to determine whether the agent also increases survival in advanced cancers relative to currently used therapies. <h3>Head and Neck Cancer.—</h3> Activity of cisplatin alone against unresectable squamous cell
Does excessive alcohol consumption worsen HCV-liver disease? Tulane Univ and VA Med Ctr, New Orleans, LA
Journal: Hepatology (1995)

Mast cells are involved in various liver diseases and appear to play a broader pathogenic role than originally thought. They may participate in the splanchnic alterations related to a porto-systemic shunt. To verify this hypothesis we studied the serum and hepatic histological changes in rats four weeks after an end-to-side portacaval shunt. In this experimental model of chronic liver insufficiency we also assessed the mucosal mast cells (MMC) and connective tissue mast cells (CTMC) in the liver, mesenteric lymph nodes and small intestine, as well as the serum levels of rat mast cell protease-II (RMCP-II). The results show liver and testes atrophy, with hypoalbuminemia (p = 0.0001), hyperbilirubinemia (p = 0.0001) and increase in aspartate aminotransferase (p = 0.004) and alanine aminotransferase (p = 0.0001). Hepatic histopathology demonstrates hepatocytic necrosis and apoptosis, portal inflammation, biliary proliferation, steatosis and fibrosis. There is a decrease of MMCs and CTMCs in the liver, while in the ileum CTMCs increase and MMCs decrease. These results suggest the involvement of mast cells in the pathophysiological splanchnic impairments in this experimental model. In particular, the decreased number of liver mast cells may be associated with the hepatic atrophy. If this is the case, we propose that the disruption of the hepato-intestinal axis after a portocaval shunt in the rat could inhibit the ability of the liver to developing an appropriate repair response mediated by mast cells.
Editorial: Restrictions on coroners' juries.
Journal: BMJ (1975)

results obtained when antifungal drugs were combined with surgery.Taking nine patients managed this way from published reports together with 11 of their own the mortality was 20%.The Los Angeles team advocate surgery within 48 hours of diagnosis (thus minimizing the time during which the organism may grow into the myocardium), with removal of the infected valve and irrigation of the infected site with a solution of amphotericin B (1 g per litre of Ringer's solution) for a period of 15 minutes before the prosthetic valve is inserted.After operation they recommend a prolonged course of ampho- tericin B given intravenously in a dose of 10 mg increasing to 50 mg if tolerated, three times weekly, possibly up to a total dose of 2 500 mg.Experience of this condition has shown that its diagnosis constitutes a surgical emergency, and that few patients will survive with chemotherapy alone.
Ophthalmology
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cooperative study of hospital frequency and character of transient ischemic attacks. VI. Patients examined during an attack
Authors: T. R. Price
Journal: JAMA (1977)

Examination during an episode of transient ischemic attack (TIA) was performed on 121 of 1,307 patients suspected of having a single type of TIA. This examination supported the diagnosis of TIA in 79 patients and contributed to the establishment of a diagnosis other than TIA in 42. Although the examination increased diagnostic reliability, it did not always result in a definite diagnosis. The most common neurologic findings during a TIA were weakness of an arm or side of the face. Important findings not suggested by history included visual defects and blood pressure fluctuation. Also unexpected were the absence of findings such as sensory deficits in the presence of sensory complaints, retinal emboli, and cardiac abnormalities. Severe arteriosclerotic disease was less evident, the attacks were longer and more severe, and monocular blindness was rare. (<i>JAMA</i>238:2512-2515, 1977)
Histopathologic distinctions in the relationship of estrogens and endometrial cancer
Authors: R. I. Horwitz
Journal: JAMA (1981)

The slides of 233 patients included in a case-control study of estrogens and endometrial cancer were reviewed to determine how often endometrial cancer was misdiagnosed and whether patients with uterine cancer had other coexistent endometrial diseases. Reasonably close agreements were found among the original diagnoses and those of three additional reviewers (the total range of disagreements among all pathologists was from 2% to 16%). Proliferative and hyperplastic endometrium coexisted in many specimens from patients with endometrial cancer, and especially in those who had used estrogen replacement therapy. In contrast, estrogen therapy had seldom been used by patients whose cancers were not accompanied by these proliferative and hyperplastic lesions. In addition, these changes were found significantly more often in women with grade 1 cancers than grade 2 or 3 cancers. We conclude from these data that diagnostic misclassification is uncommon and that coexistent proliferative and hyperplastic lesions occur frequently, especially among women with grade 1 cancers. The data also suggest that the frequent finding of grade 1 cancer in estrogen users is due to bleeding that results from the stimulated coexistent benign proliferating endometrium. (<i>JAMA</i>1981;246:1425-1427)
Complement-induced granulocyte aggregation. Importance in myocardial infarction and shock lung
Authors: H. S. Jacob
Journal: JAMA (1981)

<h3>JAMA:</h3> What will hematology be like in the future? <h3>Jacob:</h3> First you have to look at its past. Fifty years ago hematology was a morphological specialty. Then, biochemistry crept in; the real beginning was the elucidation of the enzymatic defect in glucose 6-phosphate dehydrogenase deficiency, opening up study of RBC biochemistry. Soon the biochemistry of hemoglobin and of the RBC enzyme machinery was actively studied, and these areas have certainly advanced dramatically in the last 15 years. The RBC, being an easily studied cell, found more general use, as well, in work in membrane biochemistry. In the past, the inflammatory cells, including lymphocytes and phagocytes such as granulocytes and monocytes, were the exclusive province of workers in immunology and infectious disease, but in the last ten years, a number of hematologists, including our own group, have been interested in the physiology of the inflammatory cell. This is reflected in our
The Pathological Effects upon Rats of Excess Irradiated Ergosterol
Journal: Journal of Clinical Investigation (1930)

Artide by Paul Resnikoff, "Nudleotide Therapy in Agranulocytosis" Page 381, footnote to be appended: Dr. Henry Jackson, Jr. suggests to me that the compounds adenine sulfate and guanine hydrochloride should not be called nucleotides but purine salts derived from nucleotides.The work of Doan quoted in this article was carried out with nucleotides containing these purines.
An Atlas of Acquired Diseases of the Heart and Great Vessels. Vol. I, Diseases of the Valves and Pericardium; Vol. II, Coronary Arterial Disease, Systemic Hypertension, Myocardiopathies, the Heart in Systemic Disease, and Cor Pulmonale, Acute and Chronic; Vol. III, Diseases of the Great Vessels.
Journal: Annals of Internal Medicine (1962)
Abstract 3724: Molecular mechanisms of TTField action determined by measurements and modelling of electro-conductive properties of microtubules
Authors: Aarat P. Kalra, Sahil Patel, Asadullah Bhuiyan, Jordane Preto, Vahid Rezania, John D. Lewis, Karthik Shankar, Jack Tuszynski
Journal: Cancer Research (2019)

Abstract Biological effects of AC electric fields at frequencies between 100-300 kHz discovered a decade ago are being applied to cancer cells as a therapeutic modality in the treatment of glioblastoma multiforme (GBM). They are called Tumor Treating Fields (TTFields) as they disrupt cell division. Based on our electro-conductive measurements and modeling, we provide an assessment of possible molecular-level mechanisms. Computer simulations and experimental measurements carried out for microtubules and actin filaments are presented. Charge and dipole values for monomers and dimers as well as polymerized forms of these proteins are summarized. Continuum approximations for cable equations describing actin filaments and microtubules compare favorably to measurements in buffer solutions showing soliton waves and transistor-like amplification of ionic signals, respectively. AC Conductivity and capacitance of tubulin and microtubules have been measured and modeled in the range of frequencies between 1 Hz and 1 MHz. A dramatic change in conductivity occurs when tubulin forms microtubules. In living cells, this signals a conductive phase transition coinciding with mitosis in dividing cells. This process is allowed by TTField penetration into the cleavage furrow in dividing cells and provides the most significant mechanistic explanation of the observed effects. We provide estimates of the forces, energies and power involved in the action of TTFields on microtubules and kinesin motors. These calculations are compared and contrasted with typical values experienced at a cell level and provide strong arguments for real physical effects of TTFields in dividing cells. We also show results of DLS and TEM measurements on microtubules and tubulin oligomers in solution, which allow us to quantify these processes under controlled conditions. In conclusion, the most likely candidates to provide a quantitative explanation of these effects are ionic condensation waves around microtubules as well as dielectrophoretic effects on the dipole moments of microtubules. Citation Format: Aarat P. Kalra, Sahil Patel, Asadullah Bhuiyan, Jordane Preto, Vahid Rezania, John D. Lewis, Karthik Shankar, Jack Tuszynski. Molecular mechanisms of TTField action determined by measurements and modelling of electro-conductive properties of microtubules [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3724.
Consent to treatment: the medical standard reaffirmed.
Journal: BMJ (1984)

The Court of Appeal decision in Sidaway v. Bethlem Royal Hospital rejected American and Canadian developments in informed consent law and reaffirmed the established British medical standard based on the practice accepted as proper by a body of skilled and experienced physicians. Relying on North American case law, a plaintiff disabled as a result of elective surgery claimed that she had been denied the right of full disclosure of all real risks inherent in the procedure, and that the Court should decide the extent of disclosure required. The Court dismissed the appeal, noting also that a contrary decision would be damaging to the physician patient relationship and the practice of medicine.
Basal Cell and Squamous Cell Carcinoma in Persons Younger Than 40 Years
Authors: Jashin J Wu, Shahdad E Behnam, Douglas J Fife, David B Huang
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"Radium in Ophthalmology."
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GENERAL SURGICAL ANESTHESIA.
Authors: ERNEST J. MELLISH
Journal: JAMA (1903)

<h3>SELECTION OF AN ANESTHETIC.</h3> In order to receive favorable comparative consideration, an anesthetic should possess these qualities: Immediate and remote safety; least disagreeable to take; best calculated to quickly produce and maintain muscular relaxation, followed by the minimum of ill effects, as vomiting, depression, respiratory troubles, renal disturbance; minimum influence on the question of hemorrhage; best adapted to the individual case. In the vast majority of cases the choice lies between ether and chloroform. It has been proven beyond reasonable doubt that, all things considered, chloroform is more dangerous than ether, both immediately and remotely. The immediate safety (during administration) is so overwhelmingly in favor of ether that I do not hesitate to assert that those who hold to the contrary can not be fully acquainted with the facts. There are really very few contraindications to the use of ether when skilfully administered by the "open" method. It is
The use of anencephalic neonates as organ donors. Council on Ethical and Judicial Affairs, American Medical Association
Journal: JAMA (1995)

HUNDREDS of children die each year of cardiac, hepatic, or renal failure because there are not enough hearts, livers, or kidneys available for transplantation from other children. Consequently, various measures have been considered over the years to increase the organ supply for pediatric transplantation. One approach that has received particular attention is the possibility of using organs from anencephalic neonates.<sup>1-3</sup>Because anencephalic neonates face a certain and generally imminent death and because they lack any degree of consciousness, many commentators have proposed that organs of anencephalic neonates be used for transplantation, and many parents of such neonates request that their child's organs be given to other children. Permitting such organ donation would allow some good to come from a truly tragic situation, sustaining the lives of other children and providing psychological relief for those parents who wish to give meaning to the short life of the anencephalic neonate. Indeed,