tbuckley/cabot-search huggingface dataset:
Abbott's Bacteriology. The Principles of Bacteriology: A Practical Manual for Students and Physicians.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MASSAGE IN SURGERY.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Family medicine research. Status at the end of the first decade
Authors: L. Culpepper
Journal: JAMA (1983)

In a national survey of family medicine university units and residencies, 549 MD and 135 PhD faculty pursuing family medicine research were identified. Resources available for research were assessed, as were practice data system characteristics. The practice base nationally of programs pursuing research included 2.6 million patients from 1 million families, making 5.1 million visits per year. Common major impediments to research reported by programs included lack of faculty time (78%), lack of funding for faculty (61%) or staff, equipment and supplies (48%), and lack of research skill (45%) and role models (43%). The annual amount of all research grants received for calendar year 1979 was $3.4 million, of which $2.6 million was from federal government sources. This represented 0.06% of the federal health research effort. Continued development of family medicine research will require increased funding support both for research and research training. (<i>JAMA</i>1983;249:63-68)
Abstract 1913: Role of glypican 1 in regulating fibroblast activation in the prostate cancer tumor microenvironment
Authors: Sukhneeraj P. Kaur, Hee K. Lee, Robert D. Arnold, Brian S. Cummings
Journal: Cancer Research (2019)

Abstract Cancer is a heterogeneous collection of neoplastic cells, surrounded by non-malignant, stromal cells, and extracellular matrix (ECM), among other constituents. Cross-talk between tumor and stromal cells forms a dynamic tumor microenvironment (TME) that mediates cell growth, proliferation, and metastasis. The TME can inhibit cancer growth and proliferation during the initial stages of carcinogenesis; however, cancer cells can evade these inhibitory signals, and reshape the TME, making it more amenable to their own growth. This gives rise to cancer-associated stromal cells, including cancer-associated fibroblasts (CAFs). CAFs further modulate the TME by regulating the release of growth signals, cell death, ECM remodeling, angiogenesis, and epithelial-mesenchymal transition. Glypican-1 (GPC1) is a cell surface heparan sulfate proteoglycan (HSPG) that has both pro-mitogenic and pro-metastatic activity. GPC1’s role in regulating fibroblasts and their transformation into CAFs has not been investigated. We studied the ability of prostate cancer cells to alter the TME in vitro by exposing human bone fibroblasts (HS-5 cells) to tumor conditioned media (TCM) isolated from a human neuroendocrine (DU-145) and bone (PC-3) metastatic prostate cancer cell lines and assessed changes in cell morphology and cytotoxicity (using MTT). Exposure of HS-5 cells to TCM from DU-145 and PC-3 cells altered cellular morphology to a more mesenchymal phenotype similar to that seen in active myofibroblasts. TCM also decreased MTT staining in a time-dependent manner. We also determined the effect of GPC1 knockdown (KD) in HS-5 cells on cell morphology, migration and cytotoxicity. Interestingly, we saw phenotypic switching of GPC1 KD HS-5 cells to a myofibroblast like morphology akin to that when treated with TCM. There was no change in cytotoxicity in GPC1 KD HS-5 cells as compared to control cells. However, GPC1 KD enhanced the migration of HS-5 cells in wound healing assay. Migration was also increased in GPC1 KD HS-5 cells upon treatment with TCM. GPC1 KD also increased HS-5 cell contractility significantly. Collectively, these data support the hypothesis that GPC1 plays an inhibitory role in the TME of prostate cancer by regulating the activation of fibroblasts. Citation Format: Sukhneeraj P. Kaur, Hee K. Lee, Robert D. Arnold, Brian S. Cummings. Role of glypican 1 in regulating fibroblast activation in the prostate cancer tumor microenvironment [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1913.
CONTRIBUTION A L'ETUDE DU POLLEN ET DES MOISISSURES ATMOSPHERIQUES DES VILLES DE B. ET DE G. B. (REGION SOUS‐CARPATIQUE MERIDIONALE DE LA ROUMANIE)
Authors: ELENA CAPETTI, I. GR. POPESCO, T. GHEORGHIU, I. DOBRE, C. NǍSTASE
Journal: Allergy (1969)
Diverse T Cell Responses Lead To The Different Manifestations Of Cutaneous Graft-Versus-Host Disease
Authors: Marie-Charlotte Brüggen, Irene Klein, Wolfgang Bauer, Hildegard T Greinix, Zoya Kuzmina, Werner Rabitsch, Peter Kalhs, Robert M Knobler, Georg Stingl, Georg Stary
Journal: Blood (2013)
ELEPHANTIASIS A SEQUEL OF REMOVAL OF THE INGUINAL GLANDS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serum salicylate levels in blood donors
Authors: W. P. McCann
Journal: JAMA (1970)

Salicylate levels were determined in serum from 240 volunteer blood donors who had denied recent drug exposure. Twenty-seven serum samples had levels ranging from 1.6 to 13.6 mg/100 ml, indicating exposure to salicylate preparations, which presumably were not considered by donors to be drugs. The observed elevated salicylate levels might affect adversely an extremely hypersensitive blood or plasma recipient. Salicylate ingestion might also suppress fever in donors.
Phase I Study of Paclitaxel Given by Seven-Week Continuous Infusion Concurrent with Radiation Therapy for Locally Advanced Non–Small Cell Lung Cancer
Authors: David I. Rosenthal, Clifton David Fuller, Mitchell Machtay, Kenneth M. Algazy, Dan M. Meyer, Larry R. Kaiser, Denise A. Yardley, Megan E. Loiacano, David P. Carbone
Journal: Journal of Thoracic Oncology (2006)
Phenotypic Correction of von Willebrand Disease Type 3 Blood-Derived Endothelial Cells with Lentiviral Vectors Expressing von Willebrand Factor.
Authors: Simon F. De Meyer, Karen Vanhoorelbeke, Marinee K. Chuah, Inge Pareyn, Veerle Gillijns, Robert P. Hebbel, Hans Deckmyn, Thierry Vandendriessche
Journal: Blood (2005)
Targeting inhibitor of apoptosis proteins (IAPs) enhances intrahepatic antiviral immunity to clear hepatitis B virus infection in vivo
Authors: Xiaoyong Zhang, Kuiyuan Huang, Wei Zhu, Geng Zhang, Jiehua Chen, Xuan Huang, Hongyan Liu, Yifan Zhai, Dajun Yang, Jinlin Hou
Journal: Journal of Hepatology (2020)
Factorial trials
Authors: P. Sedgwick
Journal: BMJ (2010)

Researchers investigated the effects of two separate interventions—dietary advice and knee strengthening exercises—on knee pain and function using a pragmatic factorial randomised controlled trial of two years’ duration.1 Trial participants were overweight or obese adults in the community recruited at their general practice. The dietary intervention consisted of individualised advice on healthy eating. The knee strengthening exercise intervention was a home based self managed programme. For both interventions, the control arm was an advice leaflet based on the Arthritis Research Campaign (United Kingdom) leaflet for osteoarthritis of the knee. Which of the following, if any, are true?
The protective effects of a sense oligonucleotide drug targeting inducible nitric oxide synthase for a rat model of acute liver injury
Authors: Richi Nakatake, Tetsuya Okuyama, Masaki Kaibori, Tadayoshi Okumura, Mitsugu Sekimoto, René Tolba, Mikio Nishizawa
Journal: Journal of Hepatology (2020)
Pregnancy outcome in women with sickle cell trait
Authors: P. Blattner
Journal: JAMA (1977)

A prospective study was carried out to discern the outcome of pregnancy and distribution of birth weights of infants delivered of 85 women with sickle cell trait (AS) compared with a control group of 85 women with normal hemoglobin (AA) who were matched for race, age, parity, and sex of offspring. The distribution of birth weight of offspring of primiparous and multiparous women and the proportion of low-birth-weight infants did not differ significantly between infants born to mothers with AS and those in the control group. Similarly, there was no statistically significant difference between the birth weight of infants born to primipara or multipara. Also, the overall incidence of complications among women with AS did not differ from the incidence in the control group. These findings do not support previous reports that there may be definable pathologic correlates of childbearing in women with AS. (<i>JAMA</i>238:1392-1394, 1977)
UNIFORM MEDICAL LEGISLATION.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Misleading Statement
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 605: High Molecular Weight Kininogen Prevents Vascular Smooth Muscle Progenitor Cell Accumulation to Sites of Vascular Injury and Prevents Neointima Formation
Authors: Daniel Sedding, Fabian Reich, Klaus Preissner, Harald Tillmanns
Journal: Circulation (2007)

Background: We previously described the anti-adhesive properties of endogenous high molecular weight kininogen (HKa) and its peptide domain 5 (D5) during inflammatory cell recruitment. Since bone marrow-derived vascular progenitor cells substantially contribute to the pathogenesis of vasculoproliferative diseases, this study was aimed to evaluate the effect of HKa and D5 on the accumulation of circulating cells, the function of resident cells, and the resulting vascular remodeling in a mouse model of femoral artery injury. Methods and Results: 6 weeks after lethal irradiation and bone marrow transplantation from GFP-transgenic into C57/BL6 background mice, the left femoral artery was dilated. Local peri-arterial application of HKa or D5 in a thermoresponsive polymer-gel to the injured artery reduced the accumulation of monocytes /macrophages (HKa: 9.8% ± 1.6%; D5: 4.7% ± 1.4% vs. control: 14.4% ± 1.6%) and prevented the accumulation of bone marrow-derived VSMC (GFP+/SMA+) in the neointima (HK: 16.1% ± 4.7%; D5: 6.6% ± 8.8% vs. control: 25.4% ± 3.4%). HKa and D5 also significantly reduced the number of proliferating (PCNA+) VSMC (HKa: 7.5% ± 1.9%; D5: 4.6% ± 1.9% vs. 11.9% ± 1.9%) and significantly increased the number of apoptotic VSMC in the neointima (HKa: 2.5% ± 2%; D5: 4.2% ± 2.2% vs. 1.6% ± 1.3%), resulting in a significant reduction of neointimal thickening 21 days after vascular injury, (neointima/media ratio HKa: 0.981 ± 0.174; D5: 0.549 ± 0.076 vs. 1.54 ± 0.150; n=6; P &lt;0.05). Conclusion: Our data indicate that HKa and D5 due to their antiadhesive properties decrease the inflammatory response, the accumulation of bone marrow-derived cells and the proliferation of local neointimal VSMC, resulting in reduced neointima formation. Thus, these data add substantially to the understanding of the role of endogenous HKa, and therapeutic application of HKa may represent a novel approach to prevent vascular proliferative disease.
Excess mortality after HIV seroconversion has greatly decreased in the past 10 years
Authors: Richard D. Moore
Journal: Annals of Internal Medicine (2008)

ACP Journal ClubNovember 18, 2008Excess mortality after HIV seroconversion has greatly decreased in the past 10 yearsRichard D. Moore, MD, MHSRichard D. Moore, MD, MHSJohns Hopkins University School of Medicine, Baltimore, Maryland, USA (R.D.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-10-200811180-02015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationBhaskaran K, Hamouda O, Sannes M, et al. Changes in the risk of death after HIV seroconversion compared with mortality in the general population. JAMA. 2008;300:51-9. https://pubmed.ncbi.nlm.nih.gov/18594040Clinical Impact RatingsInfectious Disease: References1 Hammer SM, Eron JJ Jr, Reiss P, et al. Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel. JAMA. 2008;300:555-70. [PMID: 18677028] Google Scholar2 Keruly JC, Moore RD. Immune status at presentation to care did not improve among antiretroviral-naive persons from 1990 to 2006. Clin Infect Dis. 2007;45:1369-74. [PMID: 17968837] Google Scholar3 Branson BM, Handsfield HH, Lampe MA, et al. Revised recommendations for HIV testing of adults, adolescents, and pregnant women in health-care settings. MMWR Recomm Rep. 2006;55(RR-14):1−17. [PMID: 16988643] Google Scholar Author, Article, and Disclosure InformationAffiliations: Johns Hopkins University School of Medicine, Baltimore, Maryland, USA (R.D.M.) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics November 18, 2008Volume 149, Issue 10Page: JC5-15KeywordsAgingAntiretroviral therapyCardiovascular diseasesDrug adherenceDrug therapyDrugsForecastingHIVHIV infectionsHeterosexualsInfectious diseasesMorbidity Issue Published: November 18, 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 2374: Non-canonical TGF-beta signaling modulates pancreatic ductal adenocarcinoma progression
Authors: S. Mazher Hussain, Gustavo Miranda-Carboni, Marcus A. Alvarez, Abul Elahi, Leah E. Hedrick, David Shibata, Evan S. Glazer
Journal: Cancer Research (2019)

Abstract Introduction: While the genomic and proteomic characterization of pancreatic ductal adenocarcinoma (PDAC) is extraordinarily complex, the transforming growth factor-beta (TGF-β) pathway is critically important. TGF-β has a context dependent role- it is tumor suppressive in early PDAC and tumor promotive in metastatic PDAC. Our hypothesis is that non-canonical TGF-β signaling induces metastatic PDAC. Non-canonical signaling may help explain the paradoxical nature of TGF-β in PDAC. Methods: Two cell lines were utilized- Panc-1, a cell line derived from primary PDAC, was compared to Capan-1, a cell line derived from metastatic PDAC- in order to model an early PDAC (Panc-1) and a more aggressive PDAC (Capan-1). We investigated the gene and protein expression of markers of epithelial to mesenchymal transition (Snail and Twist), Akt, β-catenin, and PD-L1 upon treatment with TGF-β and the Akt inhibitor MK-2206. Results: While TGF-β increased Snail gene and protein expression in Panc-1 cells, it had nil effect on Capan-1 cells where TWIST1 protein expression increased with TGF-β. TGF-β increased pAkt expression in both cell lines. TGF-β increased active and total β-catenin expression in Capan-1 but not Panc-1 cell lines. We then found that PD-L1 expression was generally diminished by Akt inhibition in both cell lines but this was reversed with TGF-β receptor inhibition and gemcitabine treatment in the Capan-1 cells. Conclusions: Our data suggests that modulation of the non-canonical TGF-β pathway may lead to increased epithelial to mesenchymal transition through multiple mechanisms. PD-L1 expression is a response to chemotherapy in metastatic PDAC when multiple proteins in that pathway are inhibited. Our data suggests that (1) personalized therapy based on the degree of non-canonical TGF-β pathway activation will be critical, (2) patients with uncontrolled non-canonical TGF-β pathway activation may have lower survival, and (3) there is an opportunity to utilize anti-PD-L1 based therapy in combination with other therapy in selected patients based on their response to chemotherapy. Citation Format: S. Mazher Hussain, Gustavo Miranda-Carboni, Marcus A. Alvarez, Abul Elahi, Leah E. Hedrick, David Shibata, Evan S. Glazer. Non-canonical TGF-beta signaling modulates pancreatic ductal adenocarcinoma progression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2374.
Phenotypic variability of Filipino β°‐thalassemia/HbE patients in Indonesia
Authors: Iswari Setianingsih, Robert Williamson, Dasril Daud, Alida Harahap, Sangkot Marzuki, Susan Forrest
Journal: American Journal of Hematology (1999)

Three Indonesian patients with identical genotypes, each compound heterozygotes for Filipino β°-thalassemia/HbE, expressed different clinical severities. One patient has mild disease and is transfusion independent, while the other two are severely affected and transfusion dependent. The size of the Filipino β°-globin gene deletion was confirmed to be 45 kb, resolving conflicting values given in the literature. Neither ameliorating genetic factors such as α-globin gene deletions or the XmnI restriction site polymorphism at position -158 upstream of the Gγ-globin gene, nor differences in β-globin gene haplotype, explain the phenotypic variation. These observations have implications for the development of antenatal diagnosis in Indonesia, as at present it is not possible to give an accurate prediction of severity of phenotype for this common genotype. Am. J. Hematol. 62:7–12, 1999. © 1999 Wiley-Liss, Inc.
Letter: Childhood accidents.
Authors: Colin Brewer
Journal: BMJ (1976)

brain damage and continued excessive drink- ing represents a particularly serious threat to the lives of other road users, and if we are to take this threat seriously the assessment of convicted drunken drivers with the Hal- stead-Reitan test battery and the EMI-Scanner deserves our careful consideration not only as a possible index of current disability but also as a possible prognostic guide.I hope shortly to produce a six-year followup of our series of 33 alcoholics which may tell us whether the likelihood of relapse is related to objective indices of the extent of brain damage.
Iron induces both DNA synthesis and repair in rat hepatocyte stimulated by EGF/Pyruvate . (1) INSERM U 49, Unit� de Recherches H�patologiques, (2) Laboratoire d;h�matologie et d'Immunologie and (3) Clinique des Maladies du Foie, CHRU Pontchaillou, Rennes, France
Journal: Hepatology (1995)
Manuscripts Approved for JNCI, February 10 to March 10, 1963
Journal: JNCI Journal of the National Cancer Institute (1963)

Manuscripts Approved for JNCI, February 10 to March 10, 1963 Get access JNCI: Journal of the National Cancer Institute, Volume 30, Issue 4, April 1963, Page 846, https://doi.org/10.1093/jnci/30.4.846 Published: 01 April 1963